Cerebral autoregulation in children during sevoflurane anaesthesia.
BACKGROUND
Little is known about cerebral autoregulation in children. The aim of this study was to examine cerebral autoregulation in children.


METHODS
Cerebral autoregulation testing was performed during less than 1 MAC sevoflurane anaesthesia in children (from 6 months to 14 yr) and in adults (18-41 yr). Mean middle cerebral artery flow velocities (V(MCA)) were measured using transcranial Doppler ultrasonography. Mean arterial pressure (MAP) was increased to whichever was greater: 20% above baseline or (i) 80 mm Hg for less than 9 yr, (ii) 90 mm Hg for 9-14 yr, and (iii) 100 mm Hg for adults. Cerebral autoregulation was considered intact if the autoregulatory index was > or =0.4.


RESULTS
There were 13 subjects less than 2 yr old (Group 1), 13 subjects 2-5 yr (Group II), 14 subjects 6-9 yr (Group III), 12 subjects 10-14 yr (Group IV), and 12 adults (Group V; control group). All subjects had an autoregulatory index > or =0.4. There was no difference in autoregulatory index between children in Groups I-IV or between children and adults.


CONCLUSIONS
We found no age-related differences in autoregulatory capacity during low-dose sevoflurane anaesthesia. We report no differences in autoregulatory capacity between children and adults.
Vavilala
M S
MS
Department of Anesthesiology, University of Washington, Seattle 98104, USA. vavilala@u.washington.edu
Lee
L A
LA
Lee
M
M
Graham
A
A
Visco
E
E
Lam
A M
AM
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology; D000704:Analysis of Variance; D000768:Anesthesia, General; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D007223:Infant; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000502:physiology; D000077149:Sevoflurane; D017585:Ultrasonography, Doppler, Transcranial
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane