title: Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration.
abstract: The pharmacokinetics of colistin was investigated using specific high-performance liquid chromatography (HPLC) to measure the concentrations of colistin and colistin A and B in plasma and urine in five rats after administration of an intravenous bolus of 1 mg of colistin sulfate/kg of body weight. There were differences in the pharmacokinetic behaviors of unbound colistin A and B. This is the first report of the use of HPLC to study the pharmacokinetics of colistin and its two major components.
authors.affiliation: Centre for Pharmaceutical Research. School of Pharmaceutical, Molecular and Biomedical Sciences, University of South Australia, Adelaide, Australia.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Robert W
authors.initials: RW
authors.lastname: Milne
authors.forename: Roger L
authors.initials: RL
authors.lastname: Nation
authors.forename: John D
authors.initials: JD
authors.lastname: Turnidge
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Smeaton
authors.forename: Kingsley
authors.initials: K
authors.lastname: Coulthard
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D003091:Colistin / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate; D011485:Protein Binding; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000900:Anti-Bacterial Agents; D003091:Colistin