title: [Concomitant radiotherapy-chemotherapy for unresectable cancers of the head and neck: a retrospective analysis of 130 patients].
abstract: OBJECTIVE
  We analyzed retrospectively the files of 130 patients with unresectable cancer of the head and neck who were given concomitant radiotherapy-chemotherapy between January 1993 and February 2000.
  
  
  METHODS
  The series included 41 patients with grade III cancer, 64 grade IVA, and 25 grade IVB. Treatment combined radiotherapy (70.2 Gy centered on the tumor with 50.4 Gy on the lymph nodes) and chemotherapy using three cycles of cisplatinium combined with 5-fluorouracil in continuous infusion for 120 hr.
  
  
  RESULTS
  Local control was achieved in 51% of the patients at two years and 48% at five years. Overall survival was 45% at two years and 33% at five years, all grades included.
  
  
  CONCLUSIONS
  Univariate analysis of prognostic factors points out the importance of the nutritional status before and during treatment.
authors.affiliation: Service ORL, Hopital d'Instruction des Armées, 83000 Toulon.
authors.forename: P
authors.initials: P
authors.lastname: Resche-Rigon
authors.forename: T
authors.initials: T
authors.lastname: Pignon
authors.forename: A
authors.initials: A
authors.lastname: Giovanni
authors.forename: R
authors.initials: R
authors.lastname: Gras
authors.forename: D
authors.initials: D
authors.lastname: Bagarry
authors.forename: M
authors.initials: M
authors.lastname: Zanaret
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011829:Radiation Dosage; D012189:Retrospective Studies
vernacular_title: Radiothérapie-chimiothérapie concomitante des cancers non opérables de la tête et du cou. Etude rétrospective sur 130 patients.