title: Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme MurD.
abstract: Computer-based molecular design has been used to produce a series of new macrocyclic systems targeted against the bacterial cell wall biosynthetic enzyme MurD. Following their preparation, which involved a novel metathesis-based cyclisation as the key step, these systems were found to show good inhibition when assayed against the MurD enzyme.
authors.affiliation: Departments of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
authors.forename: James R
authors.initials: JR
authors.lastname: Horton
authors.forename: Julieanne M
authors.initials: JM
authors.lastname: Bostock
authors.forename: Ian
authors.initials: I
authors.lastname: Chopra
authors.forename: Lars
authors.initials: L
authors.lastname: Hesse
authors.forename: Simon E V
authors.initials: SE
authors.lastname: Phillips
authors.forename: David J
authors.initials: DJ
authors.lastname: Adams
authors.forename: A Peter
authors.initials: AP
authors.lastname: Johnson
authors.forename: Colin W G
authors.initials: CW
authors.lastname: Fishwick
mesh_terms: D001665:Binding Sites; D002473:Cell Wall / Q000737:chemistry / Q000378:metabolism; D017076:Computer-Aided Design; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D004926:Escherichia coli / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D010453:Peptide Synthases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D006571:Heterocyclic Compounds; D010453:Peptide Synthases; C053379:UDP-N-acetylmuramoylalanine-D-glutamate ligase