Immunogenicity of purified chick embryo cell anti-rabies vaccine in post-exposure treatment of animal bite cases.
The observations on immunogenicity of Purified Chick Embryo Cell (PCEC) anti rabies vaccination in post-exposure prophylaxis is reported. In total 207 serum samples collected from patients receiving 3 to 6 doses of PCEC were analysed for the presence of anti-rabies antibodies. The samples were collected from 10 days to 11 months after the last dose of vaccine. All the vaccinees (n=33) tested after 3 doses of PCEC showed protective titres (> or = 0.5 IU/ml) and those receiving 5-6 doses (n=161) showed 4-5 times higher than protective titres. The analysis pertains to specimens collected at one point of time only after the vaccination. However, in all 17 vaccinees where samples were collected 7-11 months after 3-6 doses of vaccine, the protective titres were sustained, these being 3-4 times higher than the protective titres in those receiving 5-6 vaccine doses. The results indicated that there was no need of routine anti-rabies antibody monitoring in healthy individuals receiving post-exposure prophylaxis in recommended doses of vaccine.
Bhardwaj
Mohan
M
National Institute of Communicable Diseases, 22-Shamnath Marg, Delhi-110 054.
Bhattacharya
Dipesh
D
Chhabra
Mala
M
Ichhpujani
R L
RL
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D001733:Bites and Stings; D002642:Chick Embryo / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D011818:Rabies / Q000276:immunology / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*; D014611:Vaccination
D000914:Antibodies, Viral; D011819:Rabies Vaccines