title: [Postoperative pain therapy with tilidin and tilidin retard as an oral patient-controlled analgesia after uncomplicated myocardial revascularization].
abstract: OBJECTIVE
  The purpose of this study was to evaluate whether or not the combination of tilidin and tilidin retard as oral patient-controlled analgesia provide a suitable pain management in patients after uncomplicated myocardial revascularization.
  
  
  METHODS
  We conducted a randomised phase IV study to evaluate the effectiveness of postoperative analgesia with tilidin and tilidin retard. Patients with a baseline tilidin retard and tilidin liquid demand medication (group B, 42 patients) were compared with a base line paracetamol and tramadol-HCl liquid demand medication (group A, 44 patients). All patients received the first dose of study medication at the second postoperative day after evaluation of the individual pain score using NRS (numeric rating scale).
  
  
  RESULTS
  Pain relief in group B was significantly better only at the second postoperative day (NRS 1,8 compared to 3,3 in group A), associated with tolerable side effects and comfortable handling.
  
  
  CONCLUSIONS
  The combination of sustained release with immediate release drugs as a patient controlled analgesia provides suitable and comfortable analgesia after myocardial bypass surgery.
authors.affiliation: Abteilung für Anästhesiologie,Bereich Schmerztherapie, Herzzentrum Kaiser-Wilhelm-Krankenhaus Duisburg.
authors.forename: T H
authors.initials: TH
authors.lastname: Cegla
authors.forename: F
authors.initials: F
authors.lastname: Walter
authors.forename: A
authors.initials: A
authors.lastname: Borchers
authors.forename: M
authors.initials: M
authors.lastname: Trenz
mesh_terms: D000284:Administration, Oral; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D006801:Humans; D009204:Myocardial Revascularization; D010149:Postoperative Pain / Q000188:drug therapy*; D011184:Postoperative Period; D013993:Tilidine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D013993:Tilidine
vernacular_title: Die postoperative Schmerztherapie mit Valoron-N-Lösung und Valoron-N-retard. Tabletten als orales Patienten-kontrolliertes Analgesieverfahren nach herzchirurgischen Routine-Bypassoperationen.