Temporal alterations in voltage gated Ca2+ channel immunoreactivities in the gerbil hippocampus following ischemic insults.
In the present study, temporal changes of voltage-gated Ca(2+) channel (VGCC) immunoreactivities were evaluated in the gerbil hippocampus following ischemia. P/Q-type VGCC immunoreactivity was elevated in the hippocampus in the 3 h post-ischemic group. In the 30 min post-ischemic group, N-type VGCC immunoreactivity began to increase only in the CA1 region. L-type (alpha1C) VGCC immunoreactivity was significantly increased in the 12 h post-ischemic group. L-type (alpha1D) VGCC immunoreactivity began to increase in the CA1 region in the 30 min post-ischemic group and peaked in the 12 h post-ischemic group. These findings suggest that the altered VGCC immunoreactivities following ischemia may play an important role in the ischemic neuronal injury.
Park
Seung-Kook
SK
Department of Anatomy, College of Medicine, Hallym University, Chunchon, Kangwon-Do 200-702, South Korea.
An
Sung-Jin
SJ
Hwang
In-Koo
IK
Suh
Jun-Gyo
JG
Oh
Yang-Seok
YS
Won
Moo Ho
MH
Kang
Tae-Cheon
TC
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D015220:Calcium Channels / Q000032:analysis / Q000096:biosynthesis*; D005849:Gerbillinae; D006624:Hippocampus / Q000737:chemistry / Q000378:metabolism*; D007120:Immunochemistry; D008297:Male; D013997:Time Factors
D015220:Calcium Channels