Successive iodine-magnesium or -copper exchange reactions for the selective functionalization of polyhalogenated aromatics.
[reaction: see text] The presence of an electron-withdrawing group or chelating group was found to direct the halogen-copper and halogen-magnesium exchange with various di- or trihalogenated aromatics. Starting with a triiodobenzoate derivative, a range of tetraacylated benzenes could be prepared and used for a short synthesis of benzodiazines.
Yang
Xiaoyin
X
Department Chemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377, Munich, Germany.
Rotter
Thomas
T
Piazza
Claudia
C
Knochel
Paul
P