title: [Reference norms of IGF binding proteins in a healthy adult population in the Czech Republic].
abstract: The aim of our paper was to calculate referential norms of insulin-like growth factor binding proteins (IGFBPs) in the adult in the Czech Republic, including their dependence on age and sex. The following commercial radioimmunological kits were used for the IGFBPs assessment: IGFBP-1 IRMA (DSL-7800), IGFBP-2 RIA (DSL-7100), IGFBP-3 IRMA (DSL-6600) and IGFBP-6 RIA (DSL-9800). The group consists of 60 serum samples, 31 samples were from men, and 29 samples from women, the average age of the group was 39 +/- 11.7 years. Referential values of IGFBPs in healthy adult population were defined as the average +/- S.D. in mg/l: IGFBP-1 0.038 +/- 0.021; IGFBP-2 0.58 +/- 0.22; IGFBP-3 3.88 +/- 0.73; IGFBP-6 0.22 +/- 0.06. Levels of the mentioned IGFBPs were not affected by gender. In the adult population IGFBP-3 levels were the highest between 20 and 29 years. IGFBP-2 and IGFBP-6 behave contrarity to IGFBP-3. IGFBP-1 does not change with the age. Our results are in agreement with data in literature.
authors.affiliation: III. interní klinika, Laborator pro endokrinologii a metabolismus 1. lékarské fakulty Univerzity Karlovy, U nemocnice 1, 128 08 Praha 1, Czech Republic.
authors.forename: Z
authors.initials: Z
authors.lastname: Lacinová
authors.forename: V
authors.initials: V
authors.lastname: Justová
mesh_terms: D000328:Adult; D000368:Aged; D018153:Czech Republic; D005260:Female; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D018969:Insulin-Like Growth Factor Binding Proteins
vernacular_title: Referencní normy vazebných proteinů IGF u zdravé dospĕlé populace v Ceské republice.