title: Serum CA-125 tumor marker in endometrial adenocarcinoma.
abstract: One hundred and seventy-four patients, mean age 61.23 +/- 9.41 years old, with irregular perimenopausal haemorrhage were included in the study. Fractional curettage was performed in all patients. When the pathohistologic findings were adenocarcinoma the concentration of CA-125 tumor marker was determined. Hysterectomy with bilateral salpingo-oophorectomy was determined. In 142 cases carcinoma was restricted to the uterus and in 32 patients extrauterine metastatic disease was found. In the former group CA-125 was positive in 130 patients with a mean value of 64.12 +/- 22.41 U/ml serum. In the latter group the cancer antigen was positive in 29 patients with a mean value of 244.82 +/- 68.11 U/ml. High production is associated with increased metastatic potential.
authors.affiliation: Department of Gynecology and Obstetrics, Merkur University Hospital, Zagreb, Croatia.
authors.forename: V
authors.initials: V
authors.lastname: Kukura
authors.forename: G
authors.initials: G
authors.lastname: Zovko
authors.forename: S
authors.initials: S
authors.lastname: Ciglar
authors.forename: L
authors.initials: L
authors.lastname: Markulin-Grgić
authors.forename: F
authors.initials: F
authors.lastname: Santek
authors.forename: M
authors.initials: M
authors.lastname: Podgajski
authors.forename: Z
authors.initials: Z
authors.lastname: Duić
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology; D000368:Aged; D018394:CA-125 Antigen / Q000097:blood*; D016889:Endometrial Neoplasms / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008875:Middle Aged; D012680:Sensitivity and Specificity
chemical_list: D018394:CA-125 Antigen