title: 5-phenyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-8(7H)-one.
abstract: The title compound, C(16)H(12)N(2)O(3), is a novel potent and selective non-competitive antagonist at AMPA/kainate receptors [AMPA is 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid and kainate is 3-carboxymethyl-4-isopropenylpyrrolidine-2-carboxylic acid]. The crystal structure has been determined at room temperature by X-ray diffraction and the seven-membered ring shows the usual boat conformation. The energy stabilization of the crystal packing of the title compound by significant hydrogen-bond interactions is discussed using theoretical computations.
authors.affiliation: Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica, Universitá di Messina, 98166 Vill. Sant'Agata, Messina, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bruno
authors.forename: Francesco
authors.initials: F
authors.lastname: Nicoló
authors.forename: Rosaria
authors.initials: R
authors.lastname: Gitto
authors.forename: Nicola
authors.initials: N
authors.lastname: Micale
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rosace