title: Contamination of abiotic surfaces: what a colonizing bacterium sees and how to blur it.
abstract: Many microbes are able to interfere with solid surfaces and trigger highly sophisticated colonization responses that include expression of specific properties such as increased resistances to antimicrobial agents. An anticontamination strategy might be to prevent adhesion by interfering with the surface-sensing processes and repelling the pioneering cells, to maintain the cellular sensitivity to antimicrobial agents. Recent studies have shown that differences in the physiological state of free-floating and attached bacteria, which could explain the increased levels of resistance, are triggered very early during attachment. Two-component-mediated signalling mechanisms are involved in these surface-sensing processes. Drugs and surface treatments able to interfere with the stimulation factors of these sensing systems (water activity and accumulation of proteins within the periplasm) could "blind" the colonizing bacteria and delay surface contamination.
authors.affiliation: Unité de Microbiologie et Génétique, Composante INSA de Lyon, CNRS UMR 5122, Bâtiment André Lwoff, 10 rue Dubois, 69622 Villeurbanne, France. lejeune@insa-lyon.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Lejeune
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001422:Bacterial Adhesion / Q000502:physiology*; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D018407:Bacterial Physiological Phenomena; D018441:Biofilms; D004352:Drug Resistance, Microbial / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D001425:Bacterial Outer Membrane Proteins