[Contribution of neurotrophic factors and cytokines to schizophrenia].
Abnormal development of the brain is implicated in the etiology and/or pathology of various psychiatric diseases, including schizophrenia. Current evidence indicates that neurotrophic factors can strongly influence neuronal phenotypic differentiation and subsequent neuronal function in synaptic plasticity. Among various neurotrophic factors, the expression of brain-derived neurotrophic factor(BDNF) and epidermal growth factor (EGF) is impaired in the brain as well as in the periphery of patients with schizophrenia. Based on this result, a novel animal model for schizophrenia has been established by perturbing the neurotrophic signaling during development. This review summarizes the latest progress of these studies.
Nawa
Hiroyuki
H
Brain Research Institute, Niigata University.
Futamura
Takashi
T
Mizuno
Makoto
M
Takahashi
Makoto
M
Toyooka
Kazuhiko
K
Someya
Toshiyuki
T
D000818:Animals; D001921:Brain / Q000254:growth & development; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology; D002454:Cell Differentiation; D016207:Cytokines / Q000502:physiology*; D004195:Disease Models, Animal; D004815:Epidermal Growth Factor / Q000502:physiology; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology*; D009473:Neuronal Plasticity; D009474:Neurons / Q000166:cytology / Q000502:physiology; D012559:Schizophrenia / Q000209:etiology*; D013569:Synapses / Q000502:physiology
D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines; D009414:Nerve Growth Factors; D004815:Epidermal Growth Factor