title: Primary carcinoid tumor in a polycystic kidney.
abstract: A case of a primary carcinoid tumor within a polycystic kidney is reported. A 51-year-old woman with autosomal dominant polycystic kidney disease (ADPKD) underwent a bilateral nephrectomy because of an infection in her polycystic kidneys. A tumor (1.5 cm in diameter) was incidentally found close to the hilum of the left kidney. Histologically, the tumor exhibited a predominantly trabecular pattern of cuboidal or columnar cells. Grimelius staining showed numerous silver-stained neurosecretory granules in most of the tumor cells; the tumor cells were also positive for chromogranin, synaptophysin, prostatic acid phosphatase (PAP) and neuron-specific enolase (NSE). The tumor was diagnosed as a primary carcinoid tumor of the kidney. Primary renal carcinoid is a very rare neoplasm, and this is the first report of such a lesion arising in a polycystic kidney.
authors.affiliation: Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Shibata
authors.forename: Hajime
authors.initials: H
authors.lastname: Okita
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shimoda
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Asakura
authors.forename: Masaru
authors.initials: M
authors.lastname: Murai
authors.forename: Michiie
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Hata
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002276:Carcinoid Tumor / Q000737:chemistry / Q000150:complications / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology*; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000737:chemistry / Q000150:complications / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor