Snares for GLUT4--mechanisms directing vesicular trafficking of GLUT4.
Fusion of GLUT4 vesicles with the plasma membrane is a key terminal step in insulin-regulated glucose transport. This fusion event is mediated by SNARE proteins, syntaxin 4, SNAP23 and VAMP2, through a process regulated by accessory proteins whose roles are still unclear. Munc18c is a key regulatory protein of syntaxin, and possibly of whole-SNARE complex cycling. Rab GTPases, through interactions with tethering molecules and SNAREs, provide targeting specificity in the GLUT4 secretory pathway. We review here insulin-mediated signaling of glucose transport, and particularly the role played by SNAREs and their accessory proteins.
Grusovin
Julian
J
CSIRO Health Science and Nutrition, 343 Royal Parade, Parkville, Victoria, Australia 3052.
Macaulay
S Lance
SL
D000818:Animals; D022162:Cytoplasmic Vesicles / Q000378:metabolism*; D051275:Glucose Transporter Type 4; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism* / Q000502:physiology; D009004:Monosaccharide Transport Proteins / Q000378:metabolism* / Q000502:physiology; D009124:Muscle Proteins; D021381:Protein Transport / Q000502:physiology; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins
D051275:Glucose Transporter Type 4; D008565:Membrane Proteins; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; C495692:SLC2A4 protein, human; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins