Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in Apc(Min) mice through different mechanisms.
We evaluated the effects of diet on intestinal tumorigenesis in male Apc(Min) mice by comparing AIN-76A diet fed ad libitum (CON); calorie intake restricted by 40% of the CON (CR); diet high in olive oil and supplemented with freeze-dried fruit and vegetable extracts (OFV); and diet high in total fat (HF). Compared with CON, the frequency of intestinal polyps was reduced by 57% by CR (P < 0.001) and by 33% OFV diet (P = 0.04). Both effective interventions reduced total body weight, lean mass, and fat mass and increased daily urinary corticosterone output, but only CR reduced serum insulin-like growth factor I and leptin. We conclude that dietary interventions can partially offset genetic susceptibility to intestinal carcinogenesis.
Mai
Volker
V
Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892-7105, USA.
Colbert
Lisa H
LH
Berrigan
David
D
Perkins
Susan N
SN
Pfeiffer
Ruth
R
Lavigne
Jackie A
JA
Lanza
Elaine
E
Haines
Diana C
DC
Schatzkin
Arthur
A
Hursting
Stephen D
SD
D000818:Animals; D001823:Body Composition / Q000502:physiology; D001835:Body Weight; D003345:Corticosterone / Q000652:urine; D004032:Diet; D002149:Energy Intake; D017491:Genes, APC; D020022:Genetic Predisposition to Disease; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007414:Intestinal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D007417:Intestinal Polyps / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control; D020738:Leptin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D020738:Leptin; D007334:Insulin-Like Growth Factor I; D003345:Corticosterone