[Effects of alcohol on membrane lipid fluidity of astrocytes and oligodendrocytes].
To explore the mechanism of neuron development retardation and myelination abnormality caused by alcohol, the membrane lipid fluidity of astrocytes and oligodendrocytes which is related to neuron and myelin development were measured by using DPH fluorescence probe. The results showed that 5 mmol/L alcohol could lead to decrease the polarization of fluorescence (Pr) and increase the lipid fluidity unit of membrane in both cells. The alteration was in obvious dose-response relationship. The effect of alcohol on astrocytes was stronger than that of oligodendrocytes. It indicated that alcohol could change lipid fluidity of cell membrane. Alcohol probably plays major role in the dysfunction of astrocytes and oligodendrocytes.
Qu
W
W
Department of Nutrition and Food Hygiene, College of Public Health, West China University of Medical Science, Chengdu 610041, China.
Zhang
B
B
Wu
D
D
Xiao
B
B
D000818:Animals; D001253:Astrocytes / Q000166:cytology*; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D009836:Oligodendroglia / Q000166:cytology*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
D000431:Ethanol