Chemoprevention of colorectal cancer: slow, steady progress.
In population-based observational studies, people had lower rates of colorectal cancer if they were taking various agents, including nonsteroidal anti-inflammatory drugs, calcium, and folate. In placebo-controlled trials in patients with familial adenomatous polyposis and in patients with sporadic colon adenomas, nonsteroidal anti-inflammatory drugs reduced the rates of adenomas, and there is a biologic rationale that they would be effective in reducing colorectal cancer as well. Randomized trials of chemopreventive agents are underway in the general population.
Burke
Carol A
CA
Department of Gastroenterology, The Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA. burkec1@ccf.org
Bauer
William M
WM
Lashner
Bret
B
D011125:Adenomatous Polyposis Coli / Q000235:genetics / Q000517:prevention & control; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D000068579:Celecoxib; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D005492:Folic Acid / Q000627:therapeutic use; D006801:Humans; D011720:Pyrazoles; D013449:Sulfonamides / Q000627:therapeutic use; D013467:Sulindac / Q000031:analogs & derivatives / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D011720:Pyrazoles; D013449:Sulfonamides; D013467:Sulindac; D005492:Folic Acid; D000068579:Celecoxib; C025463:sulindac sulfone; D001241:Aspirin