Association of mannose-binding lectin genotype with cardiovascular abnormalities in Kawasaki disease.
Kawasaki disease is an acute vasculitis of possible infectious cause, which in particular affects the coronary arteries. Young children rely mostly on their innate immune system for protection against invading microorganisms, of which mannose-binding lectin is an important component. We aimed to investigate the possible role of the gene for this molecule (MBL) in white Dutch patients with Kawasaki disease. In 90 patients, frequency of mutations in the MBL gene was higher than in healthy children. In children younger than 1 year, those with mutations were at higher risk of development of coronary artery lesions than were those without (odds ratio 15.7, 95% CI 1.4-176.5, p=0.026). Our findings suggest that the innate immune system contributes differently to pathophysiology of Kawasaki disease at various ages.
Biezeveld
Maarten H
MH
Emma Children's Hospital, Academic Medical Centre, Netherlands.
Kuipers
Irene M
IM
Geissler
Judy
J
Lam
Jan
J
Ottenkamp
Jaap J
JJ
Hack
C Erik
CE
Kuijpers
Taco W
TW
D016022:Case-Control Studies; D002675:Child, Preschool; D003062:Codon / Q000235:genetics; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood / Q000235:genetics*; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000235:genetics* / Q000276:immunology; D009154:Mutation; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors
D003062:Codon; D037601:Mannose-Binding Lectin