Burkholderia is highly resistant to human Beta-defensin 3.
The bactericidal activity of the novel beta-defensin hBD-3 against 28 species and 55 strains of gram-positive cocci and gram-negative fermentative and nonfermentative rods was tested. All strains proved to be highly or intermediately susceptible to hBD-3 (minimal bactericidal concentration [MBC], </=50 micro g/ml), except for Burkholderia cepacia, for all 23 tested strains of which MBCs were >100 micro g/ml.
Sahly
Hany
H
Department of Medical Microbiology, Clinical Research Unit, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany. sahly@medmicrobio.unikiel.de
Schubert
Sabine
S
Harder
Jürgen
J
Rautenberg
Peter
P
Ullmann
Uwe
U
Schröder
Jens
J
Podschun
Rainer
R
D019117:Burkholderia / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D023083:beta-Defensins / Q000494:pharmacology*
C422950:DEFB103A protein, human; D023083:beta-Defensins