Alkenyl C-H insertion of iodonium ylides into pyrroles: studies toward the total syntheses of tolmetin and amtolmetin guacil.
The thermal-catalyzed or photochemical reaction of iodonium ylides with pyrroles yields exclusively alpha-substituted pyrroles in moderate to good yields. [reaction: see text]
Batsila
Christina
C
Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, GR-45110 Ioannina, Greece. lxatziar@cc.uoi.gr
Gogonas
Efstathios P
EP
Kostakis
George
G
Hadjiarapoglou
Lazaros P
LP