Bone mineral density in an outpatient population receiving enzyme-inducing antiepileptic drugs.
Antiepileptic drug (AED) use is identified as being associated with increased fracture risk. AEDs commonly associated with osteopathies are inducers of the hepatic cytochrome p450 enzyme system (EIAEDs). We performed a retrospective cross-sectional study assessing bone mineral density (BMD) in an adult outpatient population receiving EIAEDs. Patients were routinely referred for dual-energy X-ray absorptiometry to evaluate BMD. BMD was measured at the femoral neck of hip and lumbar spine. Results were presented as absolute BMD (g/cm(2)), T score, and Z score. T and Z scores were used in this analysis. As a group, those with BMD measurements represent people with intractable epilepsy. There were no statistically significant differences found in the T or Z scores by gender; therefore all analyses combined both men and women. Significant reductions in both T and Z scores were present in men and women <50 and >or=50.
Pack
Alison M
AM
Department of Neurology, Columbia University, New York, NY 10032, USA. ap390@columbia.edu
Olarte
Lucia S
LS
Morrell
Martha J
MJ
Flaster
Edith
E
Resor
Stanley R
SR
Shane
Elizabeth
E
D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use*; D015519:Bone Density / Q000502:physiology*; D003430:Cross-Sectional Studies; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013131:Spine / Q000000981:diagnostic imaging*
D000927:Anticonvulsants; D003577:Cytochrome P-450 Enzyme System