title: Evaluation of the efficacy of two potassium nitrate bioadhesive gels (5% and 10%) in the treatment of dentine hypersensitivity. A randomised clinical trial.
abstract: OBJECTIVE
  A randomised clinical trial was designed to compare the immediate efficacy (48-96 h) of two treatments with bioadhesive gels with different concentrations of potassium nitrate (NK 5% versus NK 10%) on dentine hypersensitivity (DH). We evaluated DH by means of the use of the evaporative stimulus (ES), as the main outcome, using a placebo control group as reference.
  
  
  METHODS
  Forty-five consecutive patients who, after stimulation with a blast of air, had at least one tooth with DH > or = 2 according to the verbal ratings scale (VRS) scale were selected. They were randomly treated with a bioadhesive gel with 5% NK, 10% NK or a placebo gel without NK. The DH was evaluated at baseline, days 2, 4, 7 and 14 by an examiner blind to the procedure. The response to the ES with a blast of air, to the tactile stimulation with a probe and the subjective evaluation of the patient measured on the VRS scale were recorded. Statistical analysis was made using the Kruskal-Wallis test.
  
  
  RESULTS
  A greater reduction of DH after ES was observed after 48 h of treatment in the NK10% group (35.8%) compared to the NK5% group and placebo group (11.8% and 13.4%, respectively). This difference increased significantly at 96 h (p=0.003). No significant differences were observed for the other variables. These preliminary results may support the usefulness of an NK 10% gel to reduce the DH after stimulation with a blast of air during the first 4 days of its appearance.
authors.affiliation: School of Stomatology, Section of Periodontics, University of Oviedo, Catedrático José Serrano, s/n 33006 Oviedo, Spain.
authors.forename: Susana Cuesta
authors.initials: SC
authors.lastname: Frechoso
authors.forename: Manuel
authors.initials: M
authors.lastname: Menéndez
authors.forename: Cristina
authors.initials: C
authors.lastname: Guisasola
authors.forename: Ignacio
authors.initials: I
authors.lastname: Arregui
authors.forename: José M
authors.initials: JM
authors.lastname: Tejerina
authors.forename: Alberto
authors.initials: A
authors.lastname: Sicilia
mesh_terms: D000269:Adhesives / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003807:Dentin Sensitivity / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000008:administration & dosage / Q000627:therapeutic use*; D017060:Patient Satisfaction; D010919:Placebos; D017680:Potassium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D014092:Tooth Root / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000269:Adhesives; D005782:Gels; D009566:Nitrates; D010919:Placebos; D017680:Potassium Compounds; C023844:potassium nitrate