title: Responses of muscle sympathetic nerve activity to static handgrip exercise after 14 days of exposure to simulated microgravity.
abstract: Decrease in muscle perfusion affects on cardiovascular response to exercise. Muscle hypoperfusion enhances the increase in blood pressure responses to exercise. Muscle perfusion depends not only on central blood pressure but also how fit the active muscle is above or below the heart level; muscle perfusion decreases as arm is elevated. Static exercise increases muscle sympathetic nerve activity (MSNA) innervating vessels in non-active muscles. The exercise-induced increase in MSNA is mainly mediated by stimulating chemosensitive muscle afferents in active muscles. However, the effect of arm elevation on MSNA during forearm exercise is not examined. On the other hand, space flight and simulated microgravity exposure causes reduction in muscle blood flow, suggesting chronic muscle hypoperfused condition during simulated microgravity. Therefore, there is a possibility that arm elevation after microgravity exposure alters MSNA responsiveness during exercise. However, arm elevation effect after exposure to simulated microgravity is not examined.
authors.affiliation: Department of Autonomic Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Michikami
authors.forename: A
authors.initials: A
authors.lastname: Kamiya
authors.forename: Q
authors.initials: Q
authors.lastname: Fu
authors.forename: J
authors.initials: J
authors.lastname: Cui
authors.forename: H
authors.initials: H
authors.lastname: Usui
authors.forename: S
authors.initials: S
authors.lastname: Atsuta
authors.forename: Y
authors.initials: Y
authors.lastname: Niimi
authors.forename: S
authors.initials: S
authors.lastname: Iwase
authors.forename: T
authors.initials: T
authors.lastname: Mano
mesh_terms: D001132:Arm; D001510:Bed Rest; D001794:Blood Pressure / Q000502:physiology; D015444:Exercise / Q000502:physiology; D018737:Hand Strength; D018475:Head-Down Tilt; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply / Q000294:innervation* / Q000502:physiology; D011187:Posture / Q000502:physiology*; D016683:Supine Position; D013564:Sympathetic Nervous System / Q000502:physiology*; D018474:Weightlessness Simulation; D014955:Wrist Joint