[Assessment of endogenous intoxication and thrombocyte functions in beta-thalassemia].
The parameters of humeral immunity and of the aggregation function of blood platelets were comparatively analyzed in 11 healthy and 26 children with beta-thalassemia; 18 of them had beta-thalassemia of the homozygous type (spleen was extracted in 8 children, and it remained intact in 10 children). It was demonstrated that there was an increased quantity of antibodies to blood platelets and an increased quantity of large, medium-size and small circulating immune complexes in patients with beta-thalassemia and especially in those, who did not undergo splenectomy; there was also an increased quantity of immunoglobulins of classes A, M, and G, a reduced total activity of the complement and a high parameter of the degree of endogenous intoxication, i.e. the content of medium-size molecular peptides. The mentioned disorders were accompanied by worsened aggregation abilities of blood platelets and by their increased disaggregation. Finally, insignificant changes were detected in patients with beta-thalassemia of the heterozygous type.
Orudzhev
A G
AG
Guseĭnova
E E
EE
Khalilova
I S
IS
Dzhavadov
S A
SA
D000293:Adolescent; D000936:Antigen-Antibody Complex / Q000097:blood; D001792:Blood Platelets / Q000276:immunology / Q000502:physiology*; D002648:Child; D003167:Complement Activation; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008970:Molecular Weight; D010455:Peptides / Q000097:blood / Q000737:chemistry; D010974:Platelet Aggregation; D013156:Splenectomy; D017086:beta-Thalassemia / Q000097:blood* / Q000276:immunology / Q000378:metabolism*
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010455:Peptides
Otsenka éndogennoĭ intoksikatsii i funktsiĭ trombotsitov pri beta-talassemii.