Ostruthin: an antimycobacterial coumarin from the roots of Peucedanum ostruthium.
Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 microM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-enyloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).
Schinkovitz
Andreas
A
Gibbons
Simon
S
Stavri
Michael
M
Cocksedge
Michael J
MJ
Bucar
Franz
F
D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D019661:Apiaceae; D003374:Coumarins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D014468:Umbelliferones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000995:Antitubercular Agents; D003374:Coumarins; D010936:Plant Extracts; D014468:Umbelliferones; C008719:ostruthin