title: 5-hydroxytryptamine and atrial fibrillation: how significant is this piece in the puzzle?
abstract: 5-Hydroxytryptamine, a recent addition to the list of hormonal triggers for atrial fibrillation (AF), may play a pivotal role in the induction of AF related not only to cardiac surgery but also to acute coronary syndromes, valvular heart disease, cardiomyopathies, alcoholism, aging, and conducting tissue disease. This review examines the supporting laboratory and clinical evidence and provides a comprehensive insight into the basic underlying mechanisms involved. It also delves into the potential benefits and limitations of 5-HT4 antagonists in the prevention and management of this arrhythmia.
authors.affiliation: Department of Cardiovascular Medicine, St. Georges Hospital Medical School, London, United Kingdom. syusuf@sghms.ac.uk
authors.forename: Shamil
authors.initials: S
authors.lastname: Yusuf
authors.forename: Naab
authors.initials: N
authors.lastname: Al-Saady
authors.forename: A John
authors.initials: AJ
authors.lastname: Camm
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000378:metabolism / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology; D006325:Heart Atria / Q000378:metabolism / Q000503:physiopathology*; D006329:Heart Conduction System / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D011985:Receptors, Serotonin / Q000145:classification* / Q000378:metabolism*; D012701:Serotonin / Q000145:classification* / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000627:therapeutic use
chemical_list: D000889:Anti-Arrhythmia Agents; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin