[Antagonism of folic acid on the toxicity of aspirin in yolk sac of rats].
The antagonistic effects of folic acid to aspirin on the development of rat yolk sac and embryos were studied during early organogenesis by using whole embryo culture technique and electron microscopy. The results showed that when treated with aspirin, the diameter of yolk sac and the body length of embryo were much shorter, the frequencies of abnormal embryos were significantly higher, and the yolk sac became thinner than those without treatment. The number of blood islands and capillaries decreased, the differentiation and development of blood vessel were retarded in the treated group. Ultrastructure observation also showed that the numbers of microvilli and capillaries were greatly decreased, and the structure and the numbers of lysosomes, endoplasmic reticula and ribosomes significantly changed in the treated group. When aspirin was added with high folic acid serum, the toxicity on yolk sac decreased or disappeared. The results suggested that the protection of yolk sac would be related to the antagonism of folic acid to aspirin.
Wang
X
X
Shandong Institute of Industrial Hygiene and Occupational Disease, Jinan 250062, China.
Han
M
M
D000818:Animals; D001241:Aspirin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005492:Folic Acid / Q000494:pharmacology*; D008297:Male; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013723:Teratogens / Q000633:toxicity*; D015017:Yolk Sac / Q000187:drug effects
D013723:Teratogens; D005492:Folic Acid; D001241:Aspirin