The developing heart and congenital heart defects: a make or break situation.
Congenital heart defects are common in humans, but the underlying basis for these defects is not well understood. It has been clear that abnormal heart development is at the root of these diseases, but the genes involved have remained elusive until recently. This review focuses on recent advances in our understanding of mammalian heart formation, and how some of these processes, when disrupted, lead to congenital heart defects.
Bruneau
B G
BG
Program in Cardiovascular Research, the Hospital for Sick Children, Department of Molecular and Medical Genetics, University of Toronto, ON, Canada. bbruneau@sickkids.ca
D000818:Animals; D006321:Heart / Q000196:embryology*; D006330:Heart Defects, Congenital / Q000235:genetics*; D006801:Humans; D051379:Mice; D023421:Models, Animal; D009024:Morphogenesis / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics
D014157:Transcription Factors