title: Cannabinoid exposure alters learning of zebra finch vocal patterns.
abstract: Using a well-established songbird model of juvenile vocal development, we have found that daily cannabinoid exposure at modest dosages alters sensory-motor vocal learning. Adult exposure did not change song that had already been learned. Our results demonstrate the potential for cannabinoid exposure to produce distinct effects during post-natal CNS development.
authors.affiliation: Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA. soderstromk@mail.ecu.edu
authors.forename: Ken
authors.initials: K
authors.lastname: Soderstrom
authors.forename: Frank
authors.initials: F
authors.lastname: Johnson
mesh_terms: D000818:Animals; D048588:Benzoxazines; D001921:Brain / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D002186:Cannabinoids / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D007858:Learning / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D023421:Models, Animal; D009025:Morpholines / Q000494:pharmacology; D009281:Naphthalenes / Q000494:pharmacology; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000187:drug effects* / Q000378:metabolism; D020308:Songbirds / Q000378:metabolism*; D014828:Vocalization, Animal / Q000187:drug effects* / Q000502:physiology
chemical_list: D048588:Benzoxazines; D002186:Cannabinoids; D009025:Morpholines; D009281:Naphthalenes; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; C070417:(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone