title: Chemoenzymatic synthesis of neuraminic acid containing C-glycoside polymers.
abstract: [structure: see text] Two neuraminic acid-based, C-glycoside polymers were synthesized. Preliminary studies on one of these polymers showed potent neuraminidase inhibitory activity, suggesting potential utility as an antipathogenic surface coating for the preparation of antimicrobial biomaterials.
authors.affiliation: Division of Medicinal and Natural Products Chemistry and Department of Chemical and Biochemical Engineering, The University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Qun
authors.initials: Q
authors.lastname: Wang
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Dordick
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Linhardt
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D003016:Clostridium perfringens / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006027:Glycosides / Q000138:chemical synthesis*; D006735:Horseradish Peroxidase / Q000737:chemistry / Q000378:metabolism; D009438:Neuraminic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D009195:Peroxidase / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000138:chemical synthesis*; D013025:Glycine max
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D006027:Glycosides; D009438:Neuraminic Acids; D011108:Polymers; D006735:Horseradish Peroxidase; D009195:Peroxidase; D009439:Neuraminidase