title: Absolute configuration and complete assignment of 13C NMR data for new sesquiterpenes from Maytenus chiapensis.
abstract: Five new dihydro-beta-agarofuran sesquiterpenes (1-5) were isolated from the leaves of Maytenus chiapensis. The structures of 1-5 were determined by means of 1D and 2D NMR techniques. A semiselective HMBC technique was applied in order to obtain complete (13)C NMR assignments. Absolute configurations were determined by CD studies and chemical correlations and on biogenetic grounds. Compound 4 showed weak activity against a multidrug-resistant Leishmania tropica line.
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain.
authors.forename: Marvin J
authors.initials: MJ
authors.lastname: Núñez
authors.forename: Fernando
authors.initials: F
authors.lastname: Cortés-Selva
authors.forename: Isabel L
authors.initials: IL
authors.lastname: Bazzocchi
authors.forename: Ignacio A
authors.initials: IA
authors.lastname: Jiménez
authors.forename: Antonio G
authors.initials: AG
authors.lastname: González
authors.forename: Angel G
authors.initials: AG
authors.lastname: Ravelo
authors.forename: José A
authors.initials: JA
authors.lastname: Gavin
mesh_terms: D000818:Animals; D002247:Carbon Isotopes; D002460:Cell Line / Q000187:drug effects; D002942:Circular Dichroism; D018432:Drug Resistance, Multiple; D004544:El Salvador; D007895:Leishmania tropica / Q000187:drug effects*; D029755:Maytenus / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D002247:Carbon Isotopes; D012717:Sesquiterpenes