title: Ultrasound-guided laser interstitial thermo therapy for treatment of non-resectable primary and secondary liver tumours--a feasibility study.
abstract: OBJECTIVE
  Therapeutic options for primary and secondary liver tumours not suitable for resection or transplantation are limited. In this palliative situation, the scope of ablative therapeutic procedures has improved. Laser interstitial thermotherapy is a minimal invasive procedure for local tumour destruction within solid organs. This pilot study reports initial clinical experience using ultrasound-guided percutaneous laser interstitial thermotherapy.
  
  
  METHODS
  Sixty patients between the ages of 34 and 78 years with non-resectable primary and secondary liver tumours were treated palliatively with Nd:YAG laser interstitial thermotherapy. High resolution abdominal ultrasound with power duplex was used to control the placement and coagulation procedure.
  
  
  RESULTS
  In all cases, sonographic imaging allowed exact placement of the laser probe and verification of thermocoagulation by a resulting hyperechogenic signal enhancement. The maximum diameter of laser-induced destruction measured 5 cm. Ultrasound with power duplex and echo enhancer, CT or MRI scans indicated necrosis of treated tumour lesions. No serious adverse event occurred and 30-day-mortality was zero.
  
  
  CONCLUSIONS
  Ultrasound-guided laser interstitial thermotherapy is safe and reliably ablates primary and secondary liver tumours. The combination of high resolution ultrasound and laser therapy facilitates a minimally invasive but elaborate treatment. Besides chemotherapy, this procedure could be a useful palliative treatment to control the mass of liver tumours unsuitable for resection or transplantation.
authors.affiliation: Abteilung für Gastroenterologie und Endokrinologie, Georg-August-Universität, Göttingen, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Wietzke-Braun
authors.forename: U
authors.initials: U
authors.lastname: Ritzel
authors.forename: W
authors.initials: W
authors.lastname: Nolte
authors.forename: U
authors.initials: U
authors.lastname: Leonhardt
authors.forename: T
authors.initials: T
authors.lastname: Armbrust
authors.forename: M
authors.initials: M
authors.lastname: Koc
authors.forename: M
authors.initials: M
authors.lastname: Funke
authors.forename: E
authors.initials: E
authors.lastname: Grabbe
authors.forename: G
authors.initials: G
authors.lastname: Ramadori
mesh_terms: D000328:Adult; D000368:Aged; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D007834:Lasers; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D014463:Ultrasonography / Q000379:methods*