title: Primary resistance mutations to fusion inhibitors and polymorphisms in gp41 sequences of HIV-1 non-B subtypes and recombinants.
abstract: Primary resistance mutations to fusion inhibitors and polymorphisms in gp41 sequences of non-B subtypes and recombinant HIV-1 isolates were analysed. L91H to RPR103611 was detected in one DGpol/Denv/Dgp41 recombinant; L9F and K144R, rarely reported previously, were frequent in the B region of CRF14_BG recombinants. V194I and V318A, not described in the G subtype, were detected in the G region of BG recombinants and in G subtype viruses that also show the rare mutations T115L, M118V and K90R.
authors.affiliation: Instituto de Salud Carlos III, Patogenia Viral, Majadahonda, Madrid, Spain.
authors.forename: Maria L
authors.initials: ML
authors.lastname: Villahermosa
authors.forename: Lucia
authors.initials: L
authors.lastname: Perez-Alvarez
authors.forename: Rocio
authors.initials: R
authors.lastname: Carmona
authors.forename: Maria T
authors.initials: MT
authors.lastname: Cuevas
authors.forename: Migue M
authors.initials: MM
authors.lastname: Thomson
authors.forename: Leandro
authors.initials: L
authors.lastname: Medrano
authors.forename: Elena
authors.initials: E
authors.lastname: Vazquez de Parga
authors.forename: Elena
authors.initials: E
authors.lastname: Delgado
authors.forename: José Domingo
authors.initials: JD
authors.lastname: Pedreira
authors.forename: Rafael
authors.initials: R
authors.lastname: Nájera
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D024882:Drug Resistance, Viral / Q000235:genetics*; D000077560:Enfuvirtide; D015700:HIV Envelope Protein gp41 / Q000235:genetics* / Q000627:therapeutic use; D023581:HIV Fusion Inhibitors / Q000627:therapeutic use*; D015658:HIV Infections / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics*; D010446:Peptide Fragments / Q000627:therapeutic use; D011110:Polymorphism, Genetic
chemical_list: D019380:Anti-HIV Agents; D015700:HIV Envelope Protein gp41; D023581:HIV Fusion Inhibitors; D010446:Peptide Fragments; D000077560:Enfuvirtide