[Induction of apoptosis by preoperative passive immunotherapy in resectable stomach carcinoma].
The antibody SC-1 is a human IGM molecule, which binds to a tumor specific receptor. This SC-1 receptor is detectable on biopsies, it is present in about 50% of gastric cancers. After binding of the antibody to the receptor the tumor cells go into apoptosis. 50 patients expressing the SC-1 receptor on their tumors have been treated with SC-1 prior to gastrectomy. In 80% of cases apoptosis induction could be demonstrated in the tumors. The only side effect of the SC-1 therapy was a reversible episode of fever during antibody infusion in 8% of our patients.
Timmermann
W
W
Chirurgische Universitätsklinik, Universität Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg.
Illert
B
B
Vollmers
H P
HP
Krenn
V
V
Rückle-Lanz
H
H
Wilhelm
M
M
Thiede
A
A
D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000009:adverse effects; D061067:Antibodies, Monoclonal, Humanized; D017209:Apoptosis / Q000187:drug effects*; D001706:Biopsy; D003131:Combined Modality Therapy; D005743:Gastrectomy; D006801:Humans; D007116:Immunization, Passive; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010865:Pilot Projects; D013270:Stomach / Q000276:immunology / Q000473:pathology; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology / Q000601:surgery*
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; C111124:SC-1 monoclonal antibody
Apoptoseinduktion durch präoperative passive Immuntherapie beim resektablen Magenkarzinom.