New acetylenic acids from a sponge of the genus Stelletta.
Three new acetylenic metabolites (1-3) were isolated from the sponge Stelletta sp. collected from Gagu-Do, Korea. On the basis of the results of combined spectroscopic analyses, the structures of these compounds were determined to be an acetylenic acid, its 2-methoxy analogue, and corresponding anhydride, respectively. The new compounds exhibited weak cytotoxicity against a human leukemia cell-line (K562).
Lee
Hyi-Seung
HS
Marine Natural Products Laboratory, Korea Ocean Research & Development Institute, Ansan P.O. Box 29, Seoul, 425-600, Korea.
Rho
Jung-Rae
JR
Sim
Chung J
CJ
Shin
Jongheon
J
D000480:Alkynes; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007723:Korea; D007938:Leukemia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000480:Alkynes; D000970:Antineoplastic Agents; D005231:Fatty Acids, Unsaturated; C031203:2-hexadecynoic acid