title: Cerebral autoregulation in children during sevoflurane anaesthesia.
abstract: BACKGROUND
  Little is known about cerebral autoregulation in children. The aim of this study was to examine cerebral autoregulation in children.
  
  
  METHODS
  Cerebral autoregulation testing was performed during less than 1 MAC sevoflurane anaesthesia in children (from 6 months to 14 yr) and in adults (18-41 yr). Mean middle cerebral artery flow velocities (V(MCA)) were measured using transcranial Doppler ultrasonography. Mean arterial pressure (MAP) was increased to whichever was greater: 20% above baseline or (i) 80 mm Hg for less than 9 yr, (ii) 90 mm Hg for 9-14 yr, and (iii) 100 mm Hg for adults. Cerebral autoregulation was considered intact if the autoregulatory index was > or =0.4.
  
  
  RESULTS
  There were 13 subjects less than 2 yr old (Group 1), 13 subjects 2-5 yr (Group II), 14 subjects 6-9 yr (Group III), 12 subjects 10-14 yr (Group IV), and 12 adults (Group V; control group). All subjects had an autoregulatory index > or =0.4. There was no difference in autoregulatory index between children in Groups I-IV or between children and adults.
  
  
  CONCLUSIONS
  We found no age-related differences in autoregulatory capacity during low-dose sevoflurane anaesthesia. We report no differences in autoregulatory capacity between children and adults.
authors.affiliation: Department of Anesthesiology, University of Washington, Seattle 98104, USA. vavilala@u.washington.edu
authors.forename: M S
authors.initials: MS
authors.lastname: Vavilala
authors.forename: L A
authors.initials: LA
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: A
authors.initials: A
authors.lastname: Graham
authors.forename: E
authors.initials: E
authors.lastname: Visco
authors.forename: A M
authors.initials: AM
authors.lastname: Lam
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology; D000704:Analysis of Variance; D000768:Anesthesia, General; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D007223:Infant; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000502:physiology; D000077149:Sevoflurane; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane