Evaluation of essential tremor with multi-voxel magnetic resonance spectroscopy.
The pathologic substrate of essential tremor (ET) remains unknown. The authors studied 10 patients with ET and 10 volunteers using a multislice MR spectroscopy imaging sequence. Left and right cerebellar hemisphere NAA/CR and NAA/Cho ratios were significantly smaller in the ET patients than healthy subjects. The authors' data suggest that the decreased NAA/Cr and NAA/Cho ratios within the cerebellum may represent an abnormality in neuronal function.
Pagan
Fernando L
FL
Medical Neurology Branch, National Institutes of Health, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1428, USA.
Butman
John A
JA
Dambrosia
James M
JM
Hallett
Mark
M
D000328:Adult; D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D001923:Brain Chemistry; D016022:Case-Control Studies; D002531:Cerebellum / Q000737:chemistry / Q000503:physiopathology*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D020329:Essential Tremor / Q000503:physiopathology*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged
D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline