title: Stationary night blindness or progressive retinal degeneration in mice carrying different alleles of PDE gamma.
abstract: A challenge in genetics is to understand the molecular basis of genetic and allelic heterogeneity. Divergent phenotypes caused by different variants of the same gene determine allelic heterogeneity. In the past few years, we have been studying an allelic series of mutations in the gamma-subunit of the cGMP phosphodiesterase gene (Pdeg) that resulted in visual defects ranging from stationary night blindness to progressive retinal degeneration. Here we describe the morphology and physiology of the retina in mice carrying four different Pdeg alleles: Pdeg(tm), Del 7C, Y84G, and W70A and the effect that these mutations of PDE gamma have on components of the activation and deactivation phases of phototransduction.
authors.affiliation: Jules Stein Eye Institute, UCLA School of Medicine, 100 Stein Plaza, Los Angeles, CA 90095-7000, USA. farber@jsei.ucla.edu
authors.forename: Debora B
authors.initials: DB
authors.lastname: Farber
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Tsang
mesh_terms: D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000235:genetics*; D000483:Alleles; D000818:Animals; D054707:Cyclic Nucleotide Phosphodiesterases, Type 6; D051379:Mice; D008954:Models, Biological; D009755:Night Blindness / Q000235:genetics*; D012162:Retinal Degeneration / Q000235:genetics*
chemical_list: D015106:3',5'-Cyclic-GMP Phosphodiesterases; D054707:Cyclic Nucleotide Phosphodiesterases, Type 6; C517438:Pde6b protein, mouse; C517444:Pde6g protein, mouse