title: Evaluation of a collagen patch as a method of enhancing ventriculotomy healing in Japanese quail (Coturnix coturnix japonica).
abstract: OBJECTIVE
  To assess the ability of a porcine submucosal collagen patch to enhance ventriculotomy healing in quail.
  
  
  METHODS
  Histologic assessment of wound repair after ventriculotomy. Animal Population-Eighteen adult Japanese quail.
  
  
  METHODS
  All quail had a ventriculotomy through the caudoventral thin muscle. The quail were randomly assigned to 1 of 2 groups: group I (n = 9) had routine closure and group II (n = 9) had routine closure and the application of a porcine submucosal collagen patch over the serosal surface of the ventricular suture line. Three quail from each group underwent necropsy at 7, 14, and 21 days after surgery and healing of the ventriculotomy site was evaluated by microscopy.
  
  
  RESULTS
  Ventricular mucosal epithelium was completely healed at 21 days postoperatively. Time to restoration of the ventricular submucosal integrity was variable in both groups. There was evidence of a gross or microscopic perforation in 4 quail in group II, which was statistically significant (P =.041). Quail with perforations had significantly elevated numbers of ventricular serosal lymphoid aggregates compared with those without perforations (P =.029). There were no other significant temporal differences between group I and group II for mortality or histopathologic grading of wound healing.
  
  
  CONCLUSIONS
  A porcine collagen patch did not enhance ventriculotomy wound healing. Subjectively, the collagen patch might have contributed to perforation by the generation of a lymphocytic xenograft rejection response.
  
  
  CONCLUSIONS
  Ventriculotomy can be safely performed using routine closure methods in healthy birds.
authors.affiliation: Veterinary Medical Teaching Hospital, and the Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616, USA.
authors.forename: Shannon
authors.initials: S
authors.lastname: Ferrell
authors.forename: Jonathan
authors.initials: J
authors.lastname: Werner
authors.forename: Andrew
authors.initials: A
authors.lastname: Kyles
authors.forename: Linda
authors.initials: L
authors.lastname: Lowenstine
authors.forename: Phillip
authors.initials: P
authors.lastname: Kass
authors.forename: Lisa
authors.initials: L
authors.lastname: Tell
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001715:Bird Diseases / Q000601:surgery*; D003094:Collagen; D003370:Coturnix; D005260:Female; D008297:Male; D011183:Postoperative Complications; D013272:Stomach Diseases / Q000601:surgery / Q000662:veterinary*; D013278:Stomach, Avian / Q000601:surgery*; D013536:Suture Techniques / Q000662:veterinary*; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D003094:Collagen