title: An efficient, regio- and stereoselective palladium-catalyzed route to tetrasubstituted olefins.
abstract: An efficient, regio- and stereoselective palladium-catalyzed route to tetrasubstituted olefins has been developed, which involves the intermolecular coupling of an aryl iodide, an internal alkyne, and an arylboronic acid. The reaction involves cis-addition of the aryl group from the aryl halide to the less hindered or less electron-poor end of the alkyne, while the aryl group from the arylboronic acid adds to the other end. [reaction: see text]
authors.affiliation: Department of Chemistry, Iowa State University, Ames, IA 50011, USA.
authors.forename: Chengxiang
authors.initials: C
authors.lastname: Zhou
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Emrich
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock