Dynamics of viral load rebound in plasma and semen after stopping effective antiretroviral therapy.
A rebound in the plasma and seminal viral load was detected in 12 patients after the interruption of effective highly active antiretroviral therapy. The viral rebound was generally higher in plasma, although the highest level observed during interruption was higher in semen in two patients. The reintroduction of therapy was followed by an overall decrease in HIV-RNA in plasma and semen. One to 2 months after restarting treatment, four out of seven patients showed undetectable HIV-RNA in semen.
Liuzzi
Giuseppina
G
National Institute for Infectious Diseases L. Spallanzani, Rome, Italy.
D'Offizi
Gianpiero
G
Topino
Simone
S
Zaccarelli
Mauro
M
Amendola
Alessandra
A
Capobianchi
Maria Rosaria
MR
Perno
Carlo Federico
CF
Narciso
Pasquale
P
Antinori
Andrea
A
D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis; D012661:Semen / Q000821:virology*; D013997:Time Factors; D016312:Treatment Refusal; D019562:Viral Load; D014766:Viremia / Q000188:drug therapy
D012367:RNA, Viral