Selective synthesis and reactions of 6-substituted-2-beta-galactosyl-1,2,4-triazines of potential anticancer activity.
Selective synthesis and reactions of different 6-substituted-2-beta-D-galactosyl-3-thioxo-2,3-dihydro-1,2,4-triazin-5(4H)-ones using the developed amino or aryl protecting group strategy were investigated. Primary human anticancer screening of twelve selected compounds (in vitro) resulted in an active compound against both MCF7 (Breast) and SF-268(CNS) cell lines.
Mansour
Abdel Kader
AK
Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt. clff@intouch.com
Eid
Mohga M
MM
Khalil
Nasser S A M
NS
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D005697:Galactosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D006847:Hydrocarbons, Iodinated / Q000737:chemistry; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
C480507:2-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-6-benzyl-1,2,4-triazine-3,5(2H,4H)dithione; D000970:Antineoplastic Agents; D005697:Galactosides; D006847:Hydrocarbons, Iodinated; D014227:Triazines; C014055:methyl iodide