Diarrhea associated with lansoprazole.
Lansoprazole is a proton pump inhibitor widely prescribed for gastroesophageal reflux and benign peptic ulcer disease. According to the manufacturer's package insert (TAP Pharmaceuticals, Lake Forest, IL, USA), the most common side-effects are diarrhea, headache and abdominal pain, which occur in approximately 3% of patients and are reversible with drug discontinuation. An unusual case of microscopic colitis is reported in a previously asymptomatic patient who developed new-onset diarrhea after initiation of lansoprazole. The case is reviewed and possible mechanisms of diarrhea secondary to proton pump inhibitors are discussed.
Mukherjee
Sandeep
S
Section of Gastroenterology, State University of New York Health Science at Syracuse and Veterans Affairs Medical Center, Syracuse, New York, USA. smukherjee@surgery.unmc.edu
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents / Q000009:adverse effects*; D003092:Colitis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D003113:Colonoscopy; D003967:Diarrhea / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005773:Gastroscopy; D006801:Humans; D064747:Lansoprazole; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000009:adverse effects* / Q000031:analogs & derivatives; D012460:Sulfasalazine / Q000627:therapeutic use; D016896:Treatment Outcome
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D005765:Gastrointestinal Agents; D064747:Lansoprazole; D012460:Sulfasalazine; D009853:Omeprazole