Selected methods for imaging elastic properties of biological tissues.
For millennia, physicians have used palpation as a part of the physical examination to detect pathology. The ubiquitous presence of "stiffer" tissue associated with pathology often represents an early warning sign for disease, as in the cases of breast or prostate cancer. Very often tumors are found at surgery that were occult even with modern imaging instruments. This implies that methods for estimating "hardness" of tissues would add a weapon to the medical armamentarium. To this end, this review discusses several methods of estimating tissue hardness using internal or external means of applying stress (force per unit area) and several associated methods of detecting the resulting strain (fractional length change) in an effort to image a tissue mechanical property, such as Young's modulus (ratio of stress to strain). Some investigators have developed methods of estimating stiffness or modulus, but most methods result in qualitative images of stiffness. Nevertheless, such estimates may add a great deal of information not currently available to the current field of medical imaging.
Greenleaf
James F
JF
Basic Ultrasound Research Laboratory, Department of Physiology and Biophysics, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA, jfg@mayo.edu
Fatemi
Mostafa
M
Insana
Michael
M
D000818:Animals; D003238:Connective Tissue / Q000000981:diagnostic imaging / Q000502:physiology*; D003952:Diagnostic Imaging / Q000379:methods; D004548:Elasticity; D006244:Hardness; D006245:Hardness Tests / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D009038:Motion; D010808:Physical Examination / Q000379:methods; D010812:Physical Stimulation / Q000379:methods*; D013314:Stress, Mechanical; D014463:Ultrasonography / Q000379:methods*