Do circulating cytokines really matter in sepsis?
Sepsis remains the major cause of mortality worldwide, claiming millions of lives each year. The past decade has seen major advances in the understanding of the biological mechanisms involved in this complex process. Unfortunately, no definitive therapy yet exists that can successfully treat sepsis and its complications. In this review, we will address the significance of circulating cytokines in the pathophysiology of sepsis and its relevance to new approaches in extracorporeal therapies.
Tetta
Ciro
C
Renal Research, Division of Medicine, Fresenius Medical Care, Bad Homburg, Germany. ciro.tetta@fmc-ag.com
Bellomo
Rinaldo
R
D'Intini
Vincent
V
De Nitti
Concetta
C
Inguaggiato
Paola
P
Brendolan
Alessandra
A
Ronco
Claudio
C
D016207:Cytokines / Q000097:blood*; D006440:Hemofiltration; D006801:Humans; D018805:Sepsis / Q000276:immunology* / Q000503:physiopathology* / Q000628:therapy
D016207:Cytokines