title: Virological kinetics and immunological responses to a porcine reproductive and respiratory syndrome virus infection of pigs at different ages.
abstract: The objective of this study was to measure the effect of two variables (pig age and virus strain) on selected responses (clinical signs, viraemia, virus excretion and seroconversion) of pigs following exposure to porcine reproductive and respiratory syndrome (PRRS) virus. Therefore, young (6 till 8 weeks old) and old (6 months old) pigs were infected with 3 different PRRSV strains, i.e. LV ter Huurne (LVTH), LV4.2.1 and SDSU#73. Regardless of the strain used for exposure, young pigs were more susceptible to infection as shown by a higher number of viraemic and virus excreting pigs. Strain differences were also evident. LV ter Huurne induced virus excretion in a higher number of pigs and with a higher virus titre, whereas SDSU#73 induced most severe clinical signs. LV4.2.1 induced viraemia and virus excretion in a low number of pigs. The kinetics of the antibody response differed per virus strain. The results presented here are useful in developing a less expensive standardised infection model, consisting of young pigs intranasally infected with a virulent PRRSV strain, to study the efficacy of new vaccine strains.
authors.affiliation: Department of Infectious Diseases and Chain Quality, ID-Lelystad, P.O. Box 65, 8200 AB Lelystad, The Netherlands. i.f.a.vanderlinden@id.wag-ur.nl
authors.forename: I F A
authors.initials: IF
authors.lastname: van der Linden
authors.forename: J J M
authors.initials: JJ
authors.lastname: Voermans
authors.forename: E M
authors.initials: EM
authors.lastname: van der Linde-Bril
authors.forename: A T J
authors.initials: AT
authors.lastname: Bianchi
authors.forename: P J G M
authors.initials: PJ
authors.lastname: Steverink
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation; D014066:Palatine Tonsil / Q000821:virology; D019318:Porcine Reproductive and Respiratory Syndrome / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D019316:Porcine respiratory and reproductive syndrome virus / Q000276:immunology* / Q000302:isolation & purification / Q000502:physiology; D013552:Swine; D014766:Viremia / Q000276:immunology / Q000503:physiopathology; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral