Structural and functional cellular changes induced by Burkholderia pseudomallei rhamnolipid.
In this study we report that extracellular Burkholderia pseudomallei rhamnolipid induced cytopathic changes characterized by retraction, rounding up, and, finally, detachment in phagocytic and nonphagocytic cell lines. These changes were due to a progressive reorganization of the F-actin network resulting in impaired cell cycle progression and a reduced phagocytic function of macrophages.
Häussler
S
S
Institute of Medical Microbiology. Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover. German Research Centre for Biotechnology, Braunschweig, Germany.
Rohde
M
M
von Neuhoff
N
N
Nimtz
M
M
Steinmetz
I
I
D000199:Actins / Q000378:metabolism; D000818:Animals; D016957:Burkholderia pseudomallei / Q000472:pathogenicity*; D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D003599:Cytoskeleton / Q000187:drug effects; D005434:Flow Cytometry; D020558:GTP Phosphohydrolases / Q000502:physiology; D006017:Glycolipids / Q000633:toxicity*; D051379:Mice; D008856:Microscopy, Fluorescence; D010587:Phagocytosis
D000199:Actins; D006017:Glycolipids; C418382:rhamnolipid; D020558:GTP Phosphohydrolases