title: Visually significant opacification of hydrophilic acrylic intraocular lenses--a clinico-pathological analysis.
abstract: OBJECTIVE
  To describe the clinic-pathological analysis of the visually significant opacification of the Cirrus International Hydroflex foldable hydrophilic acrylic intraocular lens (IOL) (model SC600-2, Medical Developmental Research Inc., Clearwater, Florida) and to highlight that this IOL is the same model as the Acryflex SC600-2 IOL, by the same manufacturer.
  
  
  METHODS
  Retrospective review of five eyes of four patients with opacification of their Cirrus International Hydroflex foldable hydrophilic acrylic IOLs (model SC600-2) after uncomplicated phacoemulsification and IOL implantation. Two IOLs were explanted from two patients 14 to 24 months after initial implantation. Each explanted lens was divided into equal halves, one half for scanning electron microscopy (SEM) study and the other half for transmission electron microscopy (TEM) examination. SEM and TEM samples were also subjected to energy dispersive X-ray analysis (EDX).
  
  
  RESULTS
  The IOL opacification was detected 14 to 24 months after uncomplicated phacoemulsification and IOL implantation. EDX analysis showed that the crystals contained calcium and phosphorus, presumably calcium phosphate.
  
  
  CONCLUSIONS
  The Cirrus International Hydroflex foldable hydrophilic acrylic IOL (model SC600-2) is associated with opacification, that appeared worse centrally than peripherally. This is the same model as the Acryflex SC600-2 IOL, made by the same manufacturer. The opacification consists of calcium and phosphate.
authors.affiliation: The Eye Institute, National Healthcare Group, Tan Tock Seng Hospital, Jalan Tan Tock Seng, Singapore. Vernon_Yong@ttsh.com.sg
authors.forename: V K Y
authors.initials: VK
authors.lastname: Yong
authors.forename: P A
authors.initials: PA
authors.lastname: Netto
authors.forename: W J
authors.initials: WJ
authors.lastname: Heng
authors.forename: E Y
authors.initials: EY
authors.lastname: Yap
authors.forename: H M
authors.initials: HM
authors.lastname: Lee
authors.forename: M M L
authors.initials: MM
authors.lastname: Ng
authors.forename: K G
authors.initials: KG
authors.lastname: Au Eong
mesh_terms: D000180:Acrylic Resins / Q000009:adverse effects*; D001672:Biocompatible Materials / Q000009:adverse effects*; D002114:Calcinosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*; D002118:Calcium / Q000032:analysis; D020878:Device Removal; D004577:Electron Probe Microanalysis; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008855:Microscopy, Electron, Scanning; D018918:Phacoemulsification; D010758:Phosphorus / Q000032:analysis; D011475:Prosthesis Failure; D012189:Retrospective Studies
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D010758:Phosphorus; D002118:Calcium