title: The structure and function of proline recognition domains.
abstract: One particularly abundant group of modular recognition domains consists of those that bind proline-rich motifs. Such modules, including the SH3, WW, and EVH1 domains, play a critical role in the assembly and regulation of many intracellular signaling complexes. These domains use strikingly similar molecular mechanisms of proline recognition. We discuss some of the potential biological advantages conferred by proline recognition, which may explain its widespread use in signaling.
authors.affiliation: Program in Biological Sciences, University of California San Francisco, 600 16th Street, San Francisco, CA 94143-2240, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Zarrinpar
authors.forename: Roby P
authors.initials: RP
authors.lastname: Bhattacharyya
authors.forename: Wendell A
authors.initials: WA
authors.lastname: Lim
mesh_terms: D000818:Animals; D006801:Humans; D011392:Proline / Q000737:chemistry* / Q000502:physiology*; D017434:Protein Structure, Tertiary / Q000502:physiology; D013329:Structure-Activity Relationship; D018909:src Homology Domains / Q000502:physiology
chemical_list: D011392:Proline