title: Selective synthesis and reactions of 6-substituted-2-beta-galactosyl-1,2,4-triazines of potential anticancer activity.
abstract: Selective synthesis and reactions of different 6-substituted-2-beta-D-galactosyl-3-thioxo-2,3-dihydro-1,2,4-triazin-5(4H)-ones using the developed amino or aryl protecting group strategy were investigated. Primary human anticancer screening of twelve selected compounds (in vitro) resulted in an active compound against both MCF7 (Breast) and SF-268(CNS) cell lines.
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt. clff@intouch.com
authors.forename: Abdel Kader
authors.initials: AK
authors.lastname: Mansour
authors.forename: Mohga M
authors.initials: MM
authors.lastname: Eid
authors.forename: Nasser S A M
authors.initials: NS
authors.lastname: Khalil
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D005697:Galactosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D006847:Hydrocarbons, Iodinated / Q000737:chemistry; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: C480507:2-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-6-benzyl-1,2,4-triazine-3,5(2H,4H)dithione; D000970:Antineoplastic Agents; D005697:Galactosides; D006847:Hydrocarbons, Iodinated; D014227:Triazines; C014055:methyl iodide