title: [Assessment of serum markers KL-6 and SP-D for interstitial pneumonia associated with connective tissue diseases].
abstract: There are a lot of difficulties in the estimation of interstitial pneumonia and subsequent pulmonary fibrosis associated with connective tissue diseases. Recently, serum KL-6 (KL-6) and serum surfactant protein D (SP-D) have been reported to be useful to estimate the severity of interstitial pneumonia. We investigated the usefulness of these serum markers comparing to the spirometric parameters in patients with interstitial pneumonia associated with connective tissue diseases. We found significant inverse correlation between KL-6 and spirometric % VC. Furthermore, KL-6 was more significantly inverse-related with %DLco. On the other hand, we found neither correlation between SP-D and %VC, nor between SP-D and %DLco, suggesting SP-D level seems to be not affected by the degree of pulmonary fibrosis itself. These results indicate that KL-6 is useful to estimate the severity of pulmonary fibrosis more precisely than SP-D in patients with interstitial pneumonia associated with connective tissue diseases.
authors.affiliation: National Kyushu Medical Center, Division of Internal Medicine, Clinical Research Institute, Fukuoka-city.
authors.forename: Eiichi
authors.initials: E
authors.lastname: Suematsu
authors.forename: Tomoya
authors.initials: T
authors.lastname: Miyamura
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Shimada
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Nakao
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D000941:Antigens / Q000097:blood*; D000951:Antigens, Neoplasm; D015415:Biomarkers / Q000097:blood*; D003240:Connective Tissue Diseases / Q000150:complications*; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood*; D013147:Spirometry
chemical_list: D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D037663:Pulmonary Surfactant-Associated Protein D