title: [Immunoglobulin A nephropathy and disease prognostic factors].
abstract: BACKGROUND
  Immunoglobilin A nephropathy (IgAN) is a clinicopathological entity characterized by diffuse glomerular mesangial deposition of IgA as the predominant immunoglobulin. Renal biopsy reveals a spectrum of changes in glomerula, tubulointerstitium and blood vessels. 20-50% of all patients develop end-stage renal failure 20 years after onset of disease. The aim of this study was to investigate the incidence of IgAN and to analyze clinicopathological changes and prognosis of IgAN.
  
  
  METHODS
  The study included 60 patients with biopsy-proved IgAN without some other systemic diseases or Henoch-Schonlein purpura. We analyzed clinical features of the disease, laboratory findings, findings of immunofluorescence and light microscopy and prognosis of IgAN. The study is partly retrospective and partly prospective.
  
  
  CONCLUSIONS
  Incidence of the disease in the period 1981-1997 was 9.78%. At the moment of renal biopsy 63.16% of patients had normal renal function, 31.58% had stage I and 5.25% had stage II chronic renal failure. At the end of study 21.05% of investigated patients were included into the worse stage of renal failure in regard to the initial stage. Progression of renal damage correlated with special tubulointerstitial damage and heavy proteinuria.
  
  
  CONCLUSIONS
  In this study we found severe histopathological changes in the group with already impaired renal function and these changes correlated with laboratory findings, clinical features and prognosis. Normal renal function at the moment of renal biopsy pointed to risk for further damage. Changes in the tubulointerstitium and mesangium, heavy proteinuria and hypertension affect the disease prognosis. Evolution to the higher stage of renal failure was 1.24% per year and this requires long-term follow-up of patients with IgAN.
authors.affiliation: Klinika za nefrologiju i klinicku imunologiju, 21000 Novi Sad, Hajduk Veljkova 1-3.
authors.forename: Lada
authors.initials: L
authors.lastname: Petrović
authors.forename: Slobodan
authors.initials: S
authors.lastname: Curić
authors.forename: Igor
authors.initials: I
authors.lastname: Mitić
authors.forename: Dusan
authors.initials: D
authors.lastname: Bozić
authors.forename: Slavenka
authors.initials: S
authors.lastname: Vodopivec
authors.forename: Vladimir
authors.initials: V
authors.lastname: Sakac
authors.forename: Tatjana
authors.initials: T
authors.lastname: Durdević-Mirković
authors.forename: Tatjana
authors.initials: T
authors.lastname: Ilić
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies
vernacular_title: Imunoglobulin A nefropatija i faktori prognoze bolesti.