title: The effect of zero-balanced ultrafiltration during cardiopulmonary bypass on S100b release and cognitive function.
abstract: Zero-balanced ultrafiltration (ZBUF) might reduce the systemic inflammatory response (SIRS) during cardiopulmonary bypass (CPB) by removing inflammatory mediators. The objective of this study was to determine the effect of ZBUF on postoperative serum S100b levels, a marker of neuronal injury. In addition, the possible effects of ZBUF on postoperative neurocognitive function were assessed. Sixty patients undergoing elective coronary bypass grafting were randomly assigned either to a control group or to a protocol group in which ZBUF was performed. Serum S100b levels were measured five minutes after intubation, at the end of bypass and eight and 20 hours after arrival at the intensive care unit (ICU). Cognitive function was assessed with neuropsychological tests on the day before the operation and the sixth day after surgery. The S100b level at 20 hours after arrival at the ICU was 0.27 g/L (SD 0.16) in the control and 0.25 g/L (SD 0.12) in the group with ZBUF. There were no statistical differences at any time between the two groups. S100b was not detectable in the ultrafiltrate, indicating that these results were not obscured by washout of S100b. Thirteen patients (52%) in the control group and 14 patients (56%) in the ZBUF group showed a cognitive deficit. In conclusion, ZBUF during CPB does not decrease the release of S100b. This result is not affected by washout. ZBUF did not reduce the incidence of early neurocognitive deficits. The role of SIRS in the development of cognitive dysfunction following CPB remains to be resolved.
authors.affiliation: Department of Anaesthesiology, University Medical Centre Utrecht, Utrecht, The Netherlands. m.baar@anest.azu.nl
authors.forename: M
authors.initials: M
authors.lastname: de Baar
authors.forename: J C
authors.initials: JC
authors.lastname: Diephuis
authors.forename: K G M
authors.initials: KG
authors.lastname: Moons
authors.forename: J
authors.initials: J
authors.lastname: Holtkamp
authors.forename: R
authors.initials: R
authors.lastname: Hijman
authors.forename: C J
authors.initials: CJ
authors.lastname: Kalkman
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects* / Q000379:methods; D003071:Cognition; D005260:Female; D006440:Hemofiltration / Q000592:standards*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000517:prevention & control; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D011183:Postoperative Complications / Q000517:prevention & control; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D013997:Time Factors
chemical_list: D018836:Inflammation Mediators; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human