FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase III. Structure determination.
Mori
Hiroaki
H
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3, Tokodai, Tsukuba 300-2698, Japan.
Urano
Yasuharu
Y
Kinoshita
Takayoshi
T
Yoshimura
Seiji
S
Takase
Shigehiro
S
Hino
Motohiro
M
D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D056572:Histone Deacetylase Inhibitors; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
D004791:Enzyme Inhibitors; C474179:FR 235222; D056572:Histone Deacetylase Inhibitors; D007166:Immunosuppressive Agents; D010456:Peptides, Cyclic