title: Peripheral and central mechanisms in tension-type headache: an update.
abstract: Despite the tremendous socioeconomic impact of tension-type headache surprisingly little is known about the underlying pathophysiology and treatment. Existing evidence and theories about the relation between central and peripheral mechanisms are discussed. Central sensitization is probably the most important key to understand this widespread disorder. An effective prevention or reversal of this central sensitization will probably be of major importance in future treatment strategies.
authors.affiliation: The Danish Headache Research Center, Department of Neurology N01, University of Copenhagen, Glostrup Hospital, Denmark. rigj@glostruphosp.kbhamt.dk
authors.forename: R
authors.initials: R
authors.lastname: Jensen
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000503:physiopathology*; D006801:Humans; D008881:Migraine Disorders / Q000150:complications; D009569:Nitric Oxide / Q000378:metabolism; D009619:Nociceptors / Q000502:physiology; D017933:Peripheral Nervous System / Q000503:physiopathology*; D018781:Tension-Type Headache / Q000150:complications / Q000503:physiopathology* / Q000523:psychology
chemical_list: D009569:Nitric Oxide