title: A novel microgravimetric DNA sensor with high sensitivity.
abstract: A novel method using an amplifier with a cantilever and gold nanoparticles successfully to extend the length of the target for the specific and high sensitive detection of DNA was reported. When the size of gold nanoparticle is 50 nm, a sensitivity of 10(-15)M for the single base mutation detection has been achieved.
authors.affiliation: Key Laboratory of Colloid and Interface Science, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, 100080, Beijing, China. leotao1974@yahoo.com <leotao1974@yahoo.com>
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Ji'an
authors.initials: J
authors.lastname: Tang
authors.forename: Meimei
authors.initials: M
authors.lastname: Han
authors.forename: Long
authors.initials: L
authors.lastname: Jiang
mesh_terms: D001483:Base Sequence; D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000032:analysis* / Q000737:chemistry; D004252:DNA Mutational Analysis; D006046:Gold / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D011791:Quartz / Q000737:chemistry; D012680:Sensitivity and Specificity
chemical_list: D011791:Quartz; D006046:Gold; D004247:DNA