title: [Epidemiology of candidemia in Spain - Multicenter study]
abstract: The results of the epidemiological study on candidemias with the highest number of cases carried out in Spain is presented. This study is included in the Epidemiological Survey of Candidemia in Europe supported by the ECMM in which another five countries take part. In the Spanish study, 19 hospitals participated, 290 candidemia episodes were analysed (80 in children under 15 years and 210 in adults), 293 strains of yeasts being isolated. Both in children and in adults, the risks factors more frequently observed were the intravenous catheter and previous antibiotic therapy. In adults, the most habitual underlying disease was the solid tumor and, in children, hematological diseases. Candida albicans was the most prevalent species isolated in adults (46.1%) and Candida parapsilosis in children (50%). As part of the therapy, the intravenous line was removed and antifungal treatment was prescribed to 74% and 92.5% of children, respectively and to 43.8% and 73.8% of adults. The antifungal agent of election in adults was fluconazole (54.8%) and liposomal amphotericin B (58.1%) in children. The global mortality of the study was 38.9%, which for ages was major in adults (41.4%) than in children (38.7%). The geographical distribution of the isolated species was homogeneous, C. albicans being the predominant species, with the exception of Galicia and Extremadura where C. parapsilosis was the most frequent.
authors.affiliation: Servicio de Microbiología, HospitalUniversitario La Fe, Avda. Campanar 21, E-46009 Valencia, España. peman_jav@gva.es
authors.forename: Javier
authors.initials: J
authors.lastname: Pemán
authors.forename: Emilia
authors.initials: E
authors.lastname: Cantón
authors.forename: Ana
authors.initials: A
authors.lastname: Orero
authors.forename: Angel
authors.initials: A
authors.lastname: Viudes
authors.forename: Juan
authors.initials: J
authors.lastname: Frasquet
authors.forename: Miguel
authors.initials: M
authors.lastname: Gobernado
vernacular_title: Estudio multicéntrico sobre la epidemiología de las candidemias en España.