title: Hypoxic ischemic encephalopathy associated with neonatal seizures without other neurological abnormalities.
abstract: We reported three term or near-term infants with parasagittal infarcts. Their Apgar scores were low and the amniotic fluid was meconium-stained. Resuscitation was necessary immediately after birth, but they were not stuporous and no neurological abnormalities were recognized on admission. They showed metabolic acidosis and transient hypoglycemia, and two showed hematoemesis. Seizures were observed between 2 and 15 h of age in all of them. Electroencephalography demonstrated moderate or severe depression, and CT demonstrated bilateral abnormal low densities in the border zones of the middle and posterior cerebral arteries. Two of them had mental retardation and epilepsy, although the other exhibited normal development. Our infants suggest that neonatal seizures can also occur in infants with hypoxic ischemic encephalopathy without apparent neurological abnormalities.
authors.affiliation: Department of Pediatrics, Anjo Kosei Hospital, Anjo, Japan. yoshiakisato@nifty.com
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Sato
authors.forename: Akihisa
authors.initials: A
authors.lastname: Okumura
authors.forename: Toru
authors.initials: T
authors.lastname: Kato
authors.forename: Fumio
authors.initials: F
authors.lastname: Hayakawa
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Kuno
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D004569:Electroencephalography; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications* / Q000503:physiopathology; D007231:Infant, Newborn; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy / Q000209:etiology*; D014057:Tomography, X-Ray Computed
chemical_list: D000927:Anticonvulsants; D010634:Phenobarbital