title: Growth hormone-insulin-like growth factor-1 axis, leptin and sleep in anorexia nervosa patients.
abstract: The present study characterizes the relationships between severe malnutrition, sleep, growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis, and leptin levels in anorexia nervosa (AN) patients before and after weight gain. Eleven restricting-type anorectic females (mean age = 19.7 years) with severe starvation state [mean body mass index (BMI) = 13.3] were studied using polysomnography and spectral power analysis. The hormone levels were measured in the morning after sleep recording. Eleven normal-weight, age- and gender-matched healthy volunteers without a history of any eating disorder served as controls. After nutritional treatment for about 2 months (65.7 +/- 6.4 days), sleep examinations and blood tests were repeated. At this stage, the study group consisted of 5 patients (mean BMI = 15.6). Higher IGF-1 and leptin levels were associated with longer and deeper sleep among anorectics. The sleep parameters including the percentages of stage 1 sleep and SWS as well as IGF-1 tended to normalize after only limited weight gain. Sleep disturbances in anorectics may be mediated through changes in the levels of the GH-IGF-1 axis hormones, as well as the levels of leptin.
authors.affiliation: Department of Psychiatry, University of Helsinki, Helsinki, Finland. nina.lindberg@pp3.inet.fi
authors.forename: Nina
authors.initials: N
authors.lastname: Lindberg
authors.forename: Matti
authors.initials: M
authors.lastname: Virkkunen
authors.forename: Pekka
authors.initials: P
authors.lastname: Tani
authors.forename: Björn
authors.initials: B
authors.lastname: Appelberg
authors.forename: Ranan
authors.initials: R
authors.lastname: Rimón
authors.forename: Tarja
authors.initials: T
authors.lastname: Porkka-Heiskanen
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000856:Anorexia Nervosa / Q000378:metabolism* / Q000503:physiopathology; D015992:Body Mass Index; D004569:Electroencephalography / Q000379:methods; D005260:Female; D015200:Fluoroimmunoassay / Q000379:methods; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism*; D016011:Normal Distribution; D017286:Polysomnography / Q000379:methods; D011863:Radioimmunoassay / Q000379:methods; D012890:Sleep / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology; D018709:Statistics, Nonparametric
chemical_list: D020738:Leptin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone