The structure and function of proline recognition domains.
One particularly abundant group of modular recognition domains consists of those that bind proline-rich motifs. Such modules, including the SH3, WW, and EVH1 domains, play a critical role in the assembly and regulation of many intracellular signaling complexes. These domains use strikingly similar molecular mechanisms of proline recognition. We discuss some of the potential biological advantages conferred by proline recognition, which may explain its widespread use in signaling.
Zarrinpar
Ali
A
Program in Biological Sciences, University of California San Francisco, 600 16th Street, San Francisco, CA 94143-2240, USA.
Bhattacharyya
Roby P
RP
Lim
Wendell A
WA
D000818:Animals; D006801:Humans; D011392:Proline / Q000737:chemistry* / Q000502:physiology*; D017434:Protein Structure, Tertiary / Q000502:physiology; D013329:Structure-Activity Relationship; D018909:src Homology Domains / Q000502:physiology
D011392:Proline