[Clinical analysis of 75 patients with nasopharyngeal non-Hodgkin's lymphoma].
OBJECTIVE
Nasopharynx is one of the common extranodal involved site in non-Hodgkin's lymphoma.However,no standard treatment regimen ever established for nasopharyngeal lymphoma(NPL). The purpose of this paper is to investigate the clinical characteristics and treatment results of NPL.


METHODS
The authors reviewed the records of 75 NPL patients who were managed from June 1976 to August 2001 in Cancer Center,Sun Yat-sen University,to evaluate the influence of clinical characteristics and treatment modality on survival.


RESULTS
Limited stage disease ( I/ II) was present in 90.8% of the NPL patients. The most common pathological type was intermediate grade(95.2%) and the most common immune phenotype was B-cell lineage (68.6%). These patients were treated with chemotherapy plus radiotherapy (64%),chemotherapy alone (23%),and radiotherapy alone (14%),respectively. The 2-, 5-, and 10-year overall survival rates were 79.1%, 69.8%, and 64.3%, respectively. For the patients who treated with stranded CHOP (cyclophosphamide + hydroxydaunomycin + Oncovin + prednisone) chemotherapy regimen. The 2-,5-,10-year overall survival rates were 84.6%. However, the patients treated with radiotherapy alone were associated with poor survival, 5 year survival was 0. There was no significant difference in the survival between patients treated with CHOP alone or CHOP plus radiotherapy. There was also no difference in the survival between radiotherapy dosage <or=50 Gy and >50 Gy.


CONCLUSIONS
The treatment modality for NPL should include systemic chemotherapy with CHOP regimen. Whether additional local radiotherapy is necessary,and the optimal radiation dosage warrant prospective randomized trial.
Li
Yu-Hong
YH
Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, PR China.
Jiang
Wen-Qi
WQ
Huang
Hui-Qiang
HQ
Xu
Rui-Hua
RH
Lin
Tong-Yu
TY
Xia
Zhong-Jun
ZJ
He
You-Jian
YJ
Guan
Zhong-Zhen
ZZ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004317:Doxorubicin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D011241:Prednisone / Q000627:therapeutic use*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use*
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone