title: YM-266183 and YM-266184, novel thiopeptide antibiotics produced by Bacillus cereus isolated from a marine sponge. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological properties.
abstract: Novel antibiotics, YM-266183 (1) and YM-266184 (2), were found in the culture broth of Bacillus cereus QN03323 which was isolated from the marine sponge Halichondria japonica. The structures of both antibiotics were determined by several spectroscopic experiments as new thiopeptide compounds. They exhibited potent antibacterial activities against staphylococci and enterococci including multiple drug resistant strains, whereas they were inactive against Gram-negative bacteria.
authors.affiliation: Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 1-1-8 Azusawa, Itabashi-ku, Tokyo 174-8511, Japan. nagai@ymanouchi.co.jp
authors.forename: Koji
authors.initials: K
authors.lastname: Nagai
authors.forename: Kazuma
authors.initials: K
authors.lastname: Kamigiri
authors.forename: Nakako
authors.initials: N
authors.lastname: Arao
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Suzumura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kawano
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamaoka
authors.forename: Huiping
authors.initials: H
authors.lastname: Zhang
authors.forename: Masato
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kenichi
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001409:Bacillus cereus / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D016983:Enterococcus / Q000187:drug effects; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D008970:Molecular Weight; D010455:Peptides / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011161:Porifera / Q000382:microbiology*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013210:Staphylococcus / Q000187:drug effects; D013844:Thiazoles / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; D010456:Peptides, Cyclic; D013844:Thiazoles; C474182:YM 266183; C474183:YM 266184