title: [Acute renal failure probably associated with topiramate].
abstract: A case of acute renal failure probably associated with topiramate is discussed. The patient showed a significant, progressive increase in creatinine and serum urea values 5 days after topiramate treatment onset, as well as diminished creatinine clearance and non-oliguric acute renal failure requiring haemodialysis initiation. Upon topiramate discontinuance altered parameters became normal. No significant alterations were revealed by ultrasonography and renal biopsy. Coincidence in time and the absence of other factors suggest topiramate as likely cause of renal failure.
authors.affiliation: Servicio de Farmacia. Hospital General de Castellón. Spain. ferriols_raf@gva.es
authors.forename: R
authors.initials: R
authors.lastname: Ferriols Lisart
authors.forename: A
authors.initials: A
authors.lastname: Heras Javierre
authors.forename: M
authors.initials: M
authors.lastname: Sanz Muñoz
authors.forename: E
authors.initials: E
authors.lastname: Ibáñez Benages
authors.forename: M
authors.initials: M
authors.lastname: Alós Almiñana
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D005632:Fructose / Q000009:adverse effects* / Q000031:analogs & derivatives*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D006435:Renal Dialysis; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose
vernacular_title: Fallo renal agudo probablemente asociado a topiramato.