The coupling of a trkB tyrosine residue to LTP.
Brain-derived neurotrophic factor (BDNF) and its receptor, trkB, activate cAMP-response-element-binding protein (CREB) and the transcription of genes that is crucial for long-term potentiation (LTP). Any of several signaling pathways activated by trkB could be required for LTP. A recent study using mice carrying a mutation in a specific tyrosine residue of trkB pinpoints a necessary role for the phospholipase-Cgamma (PLCgamma) pathway in CREB activation and LTP maintenance.
Ernfors
Patrik
P
Unit of Molecular Neurobiology, MBB, Karolinska Institute, S-171 77 Stockholm, Sweden. patrik.ernfors@mbb.ki.se
Bramham
Clive R
CR
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002478:Cells, Cultured; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000235:genetics / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D009154:Mutation; D051966:Phospholipase C gamma; D011505:Protein-Tyrosine Kinases; D020813:Receptor, trkB / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D014158:Transcription, Genetic; D010738:Type C Phospholipases / Q000378:metabolism; D014443:Tyrosine / Q000235:genetics / Q000378:metabolism*
D019208:Brain-Derived Neurotrophic Factor; D017362:Cyclic AMP Response Element-Binding Protein; D008562:Membrane Glycoproteins; D014443:Tyrosine; C064371:Ntrk2 protein, mouse; D011505:Protein-Tyrosine Kinases; D020813:Receptor, trkB; D010738:Type C Phospholipases; D051966:Phospholipase C gamma