title: Recurrence of symptoms of premenstrual dysphoric disorder after the cessation of luteal-phase fluoxetine treatment.
abstract: OBJECTIVE
  The aim of this study was to use the data from two clinical trials to evaluate premenstrual dysphoric disorder symptom severity after the discontinuation of fluoxetine treatment.
  
  
  METHODS
  A retrospective analysis of two clinical trials was performed. Patients were treated with fluoxetine or placebo for three cycles, with the use of several different dosing regimens, followed by single blind placebo treatment for one cycle. Assessments of relapse included the daily record of severity of problems, the Sheehan disability scale, the premenstrual tension scale-clinician rated, and the clinical global impressions-severity.
  
  
  RESULTS
  Premenstrual dysphoric disorder symptoms significantly increased after fluoxetine discontinuation. The scores did not return to baseline; however, the fluoxetine group was no longer significantly superior to placebo.
  
  
  CONCLUSIONS
  The two trials demonstrate that, after three cycles of treatment, premenstrual dysphoric disorder symptoms recur within the first cycle after treatment discontinuation. The rapid recurrence of symptoms further supports the view of premenstrual dysphoric disorder as a clinical entity distinct from depression.
authors.affiliation: Women's Behavioral Health Program, Women and Infants Hospital, Providence, RI 02905-2499, USA.
authors.forename: Teri
authors.initials: T
authors.lastname: Pearlstein
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Joliat
authors.forename: Eileen B
authors.initials: EB
authors.lastname: Brown
authors.forename: Cherri M
authors.initials: CM
authors.lastname: Miner
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage*; D006801:Humans; D008183:Luteal Phase; D015337:Multicenter Studies as Topic; D011293:Premenstrual Syndrome / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D012189:Retrospective Studies; D016037:Single-Blind Method; D013997:Time Factors
chemical_list: D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine