title: Advances in the biology of JC virus and induction of progressive multifocal leukoencephalopathy.
abstract: Since the initial description of progressive multifocal leukoencephalopathy (PML) in 1958, clinical and basic science investigators have demonstrated a growing interest in the area of neurovirology, with a recent focus on polyomaviruses. In this review, the authors present an overview of the biological properties of the human polyomavirus, JC virus (JCV), and its association with PML as the etiologic agent. Additionally, the authors provide a discussion of the current understanding of JCV molecular pathogenesis and therapeutic strategies.
authors.affiliation: Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4164, USA.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Seth
authors.forename: Frank
authors.initials: F
authors.lastname: Diaz
authors.forename: Eugene O
authors.initials: EO
authors.lastname: Major
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D007577:JC Virus / Q000502:physiology*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy* / Q000453:epidemiology / Q000821:virology*
chemical_list: D000998:Antiviral Agents