A ring-closing metathesis approach toward formal total synthesis of (+)-diplodialide A.
An asymmetric formal total synthesis of diplodialide A 1a has been achieved starting from methyl acetoacetate 6 and (R)-3-buten-2-ol 7. The macrocyclic ring core of (+)-diplodialide A 1a was constructed, in an excellent yield, by using a ring-closing metathesis strategy.
Anand
R Vijaya
RV
Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India.
Baktharaman
S
S
Singh
Vinod K
VK
D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D003500:Cyclization; D005658:Fungi / Q000737:chemistry; D007202:Indicators and Reagents; D007783:Lactones / Q000032:analysis / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism
D007202:Indicators and Reagents; D007783:Lactones; C478926:diplodialide A