Anti-inflammatory activity and gastric lesions induced by zinc-tenoxicam.
Oral administration of tenoxicam or zinc-tenoxicam complex inhibited to a similar extent carrageenin-induced paw oedema and granulomatous tissue formation in rats as well as the acetic acid induced writhing response in mice. Gastric lesions induced by oral administration of zinc-tenoxicam were reduced in number and severity when compared with those induced by tenoxicam or the co-administration of tenoxicam and zinc acetate. However, after intraperitoneal administration, both zinc-tenoxicam and tenoxicam plus zinc acetate induced a reduced number of gastric lesions as compared with tenoxicam.
Nascimento
Jorge Willian L
JW
Departamento de Análises Clínicas e Toxicológicas da Faculdade de Farmácia da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Santos
Luiz Henrique
LH
Nothenberg
Michael S
MS
Coelho
Márcio M
MM
Oga
Seizi
S
Tagliati
Carlos A
CA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000037:antagonists & inhibitors / Q000633:toxicity*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced* / Q000517:prevention & control; D008297:Male; D051379:Mice; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000517:prevention & control; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D019345:Zinc Acetate / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D002351:Carrageenan; D019345:Zinc Acetate; C032801:tenoxicam