title: [New photosensitizers of bacteriochlorin series for photodynamic cancer therapy].
abstract: New derivatives of bacteriochlorophyll a bearing an extra glutarimide exocycle were synthesized, and their reactivity was studied. Acetyl group in 3-acetyl-2,7,12,18-tetramethyl-8-ethyl-13,15- dicarboxy-17-carboxyethyl-7,8,17,18-tetrahydroporphyrin (bacteriochlorin p) was chemically modified into alpha-hydroxyethyl and vinyl groups. A simple method of preparation of vinylbacteriopurpurin esters under the catalysis by p-toluenesulfonic acid was proposed. The resulting compounds exhibit a high adsorption in the visible and near IR areas of electronic spectra, a reasonable stability, and amphiphilic properties and, therefore, may be regarded as promising photosensitizers for the photodynamic cancer therapy.
authors.affiliation: Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 119571 Russia. httos.mitht@g.23.relcom.ru
authors.forename: A F
authors.initials: AF
authors.lastname: Mironov
authors.forename: M A
authors.initials: MA
authors.lastname: Grin
authors.forename: A G
authors.initials: AG
authors.lastname: Tsiprovskiĭ
authors.forename: A V
authors.initials: AV
authors.lastname: Segenevich
authors.forename: D V
authors.initials: DV
authors.lastname: Dzardanov
authors.forename: K V
authors.initials: KV
authors.lastname: Golovin
authors.forename: A A
authors.initials: AA
authors.lastname: Tsygankov
authors.forename: Ya K
authors.initials: YK
authors.lastname: Shim
mesh_terms: D025541:Bacteriochlorophyll A / Q000737:chemistry; D001671:Biochemistry / Q000379:methods; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009369:Neoplasms / Q000628:therapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011166:Porphyrins / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
chemical_list: D025541:Bacteriochlorophyll A; D017319:Photosensitizing Agents; D011166:Porphyrins; C452433:bacteriochlorin
vernacular_title: Novye fotosensibilizatory bakteriokhlorinovogo riada dlia fotodinamicheskoĭ terapii raka.