Tome-1, wee1, and the onset of mitosis: coupled destruction for timely entry.
In a recent issue of Cell, Ayad et al. (2003) report the identification of a novel F box protein Tome-1, which mediates the destruction of mitosis-inhibitory kinase wee1 via E3 ligase SCF. Tome-1 itself is targeted for degradation by APC in G1. This synergy of destructive action by APC and SCF has important implications for timely entry into mitosis.
Lim
Hong Hwa
HH
Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Republic of Singapore.
Surana
Uttam
U
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D016203:CDC2 Protein Kinase / Q000235:genetics / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D019926:Cyclin B / Q000235:genetics / Q000378:metabolism; D005057:Eukaryotic Cells / Q000201:enzymology*; D006801:Humans; D008025:Ligases / Q000235:genetics / Q000378:metabolism; D008938:Mitosis / Q000235:genetics*; D009687:Nuclear Proteins; D010453:Peptide Synthases / Q000235:genetics / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D044843:SKP Cullin F-Box Protein Ligases; D029702:Schizosaccharomyces pombe Proteins; D043743:Ubiquitin-Protein Ligase Complexes
C473796:CDCA3 protein, human; D018797:Cell Cycle Proteins; D019926:Cyclin B; D009687:Nuclear Proteins; D029702:Schizosaccharomyces pombe Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D044843:SKP Cullin F-Box Protein Ligases; C068689:wee1 protein, S pombe; D011505:Protein-Tyrosine Kinases; C499349:WEE1 protein, human; D016203:CDC2 Protein Kinase; D008025:Ligases; D010453:Peptide Synthases