title: Bone remodeling markers in the detection of bone metastases in prostate cancer.
abstract: BACKGROUND
  Early detection of bone metastases in prostatic carcinoma is very useful in treatment and prognosis of the disease. The aim of this work was to evaluate the sensitivity and specificity of a group of bone markers in order to discriminate between prostate carcinoma patients without (M(0)) and with (M(1)) bone metastases.
  
  
  METHODS
  Sixty-seven non-treated patients with: benign prostate hyperplasia (n=21), prostatic carcinoma in several stages without bone metastases (T(X)M(0)) (n=31) and with bone metastases (T(X)M(1)) (n=15) were studied. The following markers were studied: (A) bone formation: (1) serum bone alkaline phosphatase, IRMA (Tandem Ostase, Beckman); (2) serum procollagen I amino-terminal propeptide (PINP), RIA (Orion Diagnostica); (B) bone resorption: (1) urinary collagen I amino-terminal telopeptide (NTX), ELISA (Ostex); (2) collagen I carboxy terminal telopeptide (CTX): (2A) urinary alpha-CTX, RIA (Osteometer), (2B) serum beta-CTX, Elecsys (Roche); (3) collagen I cross-linked carboxy terminal telopeptide (ICTP), RIA (Orion Diagnostica).
  
  
  RESULTS
  Levels of all bone markers were significantly higher in group M(1) than in group M(0). A complete separation of groups M(0) and M(1) was achieved with PINP and beta-CTX (100% sensitivity and specificity).
  
  
  CONCLUSIONS
  These results support the use of PINP or beta-CTX as a tool to confirm the presence or absence of bone metastases in the first staging of prostatic carcinoma patients.
authors.affiliation: Bone Pathophysiology Section, Biochemistry Laboratory, Fundación Jiménez Di;az, Avenida Reyes Católicos 2, 28040- Madrid, Spain.cpiedra@fjd.es
authors.forename: Concepción
authors.initials: C
authors.lastname: de la Piedra
authors.forename: Nilda-Adriana
authors.initials: NA
authors.lastname: Castro-Errecaborde
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Traba
authors.forename: Cioly
authors.initials: C
authors.lastname: Méndez-Dávila
authors.forename: Carmen
authors.initials: C
authors.lastname: García-Moreno
authors.forename: Lucrecia
authors.initials: L
authors.lastname: Rodriguez de Acuña
authors.forename: Jesus
authors.initials: J
authors.lastname: Rodriguez-Molina
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood* / Q000652:urine; D001859:Bone Neoplasms / Q000097:blood / Q000378:metabolism* / Q000556:secondary* / Q000652:urine; D024042:Collagen Type I / Q000097:blood / Q000737:chemistry / Q000652:urine; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D010446:Peptide Fragments / Q000097:blood / Q000652:urine; D011347:Procollagen / Q000097:blood / Q000737:chemistry; D011470:Prostatic Hyperplasia / Q000097:blood / Q000378:metabolism / Q000652:urine; D011471:Prostatic Neoplasms / Q000097:blood / Q000378:metabolism* / Q000473:pathology* / Q000652:urine; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D024042:Collagen Type I; D007527:Isoenzymes; D010446:Peptide Fragments; D011347:Procollagen; D000469:Alkaline Phosphatase