title: Functional analysis of the deficit in semantic context processes in schizophrenic patients: an event-related potentials study.
abstract: OBJECTIVE
  Schizophrenic patients exhibit a deficit in the semantic context processing strategies which might be responsible for the language and communication disorders that are characteristic of this condition. The aim of our study was to identify the nature of the contextualization processes which are lacking in schizophrenic patients, by distinguishing between processes for the generation of expectations and processes of semantic integration.
  
  
  METHODS
  Thirteen schizophrenic patients and 12 healthy controls performed two tasks: (a) a lexical decision task (LDT) with a highly structured sentence context and whose experimental characteristics made it possible to call strongly on predictive strategies, and (b) a LDT with classic semantic priming (the context being reduced to a single word). In this latter task, the small number of related words did not prompt the generation of expectations but instead called on the postlexical integration process. The event-related potentials (ERP) were recorded during the administration of the task.
  
  
  CONCLUSIONS
  In the sentence task, we observed a modulation in the N400 amplitude due to the presence of expectations both in the schizophrenic and control participants: predictable words evoked a small N400 amplitude compared to the non-predictable words. In contrast, in the simple (priming) task, the semantic link evoked an N400 amplitude modulation in the control group exclusively. Our results indicate that schizophrenics could be able to use context to activate expectations for the most highly predictable item, and that their deficit appears when the processing strategy is based on the integration of the context stored in working memory.
authors.affiliation: Equipe de Recherche en Psychologie Clinique, Université Paris VIII, 2, rue de la Liberté, 93526 cedex 02, Saint-Denis, France. milena.kostova@univ-paris8.fr
authors.forename: M
authors.initials: M
authors.lastname: Kostova
authors.forename: C
authors.initials: C
authors.lastname: Passerieux
authors.forename: J P
authors.initials: JP
authors.lastname: Laurent
authors.forename: C
authors.initials: C
authors.lastname: Saint-Georges
authors.forename: M C
authors.initials: MC
authors.lastname: Hardy-Baylé
mesh_terms: D000328:Adult; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000503:physiopathology* / Q000523:psychology; D007807:Language Tests; D008297:Male; D008569:Memory Disorders / Q000503:physiopathology / Q000523:psychology; D008875:Middle Aged; D011930:Reaction Time; D012565:Schizophrenic Psychology; D012660:Semantics