title: Challenges for clinical trials to treat progressive multifocal leukoencephalopathy.
abstract: Progressive multifocal leukoencephalopathy is a lethal complication of immunodeficiency for which no direct therapy has been achieved. The issues that have made this disease especially difficult to address are discussed, and an outline for development of future interventions is provided. A controlled trial of therapy utilizing an international group of trial groups is proposed.
authors.affiliation: Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA. cliffordd@neuro.wustl.edu
authors.forename: David B
authors.initials: DB
authors.lastname: Clifford
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy*
chemical_list: D000998:Antiviral Agents