title: The effect of taurine on the salt-dependent blood pressure increase in the voltage-dependent calcium channel beta 3-subunit-deficient mouse.
abstract: To examine the anti-hypertensive effect of taurine, we studied the effects of taurine on the salt-dependent blood pressure elevation, the electrocardiogram, and plasma catecholamine levels in the voltage-dependent calcium channel beta3-subunit-deficient mouse. In the wild-type mice, chronic high-salt loading (8% NaCl in chow) did not increase the blood pressure, whereas there was a significant increase in the systolic blood pressure in the beta3-subunit-deficient mice given a high-salt diet. Oral supplementation of taurine (3% in drinking water) could attenuate the increase in the blood pressure elicited by the high-salt diet. Plasma catecholamine levels were significantly decreased by the high-salt diet, and supplementation of taurine prevented those decreases in beta3-subunit-deficient mice. It is suggested, therefore, that chronic supplementation of taurine has an anti-hypertensive action in salt-dependent blood pressure elevation.
authors.affiliation: Department of Molecular Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: Kunie
authors.initials: K
authors.lastname: Hagiwara
authors.forename: Gorou
authors.initials: G
authors.lastname: Kuroki
authors.forename: Pei Xiang
authors.initials: PX
authors.lastname: Yuan
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Manabu
authors.initials: M
authors.lastname: Murakami
authors.forename: Takuzou
authors.initials: T
authors.lastname: Hano
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sasano
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Yanagisawa
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D015220:Calcium Channels / Q000172:deficiency* / Q000235:genetics; D004837:Epinephrine / Q000097:blood; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009638:Norepinephrine / Q000097:blood; D017673:Sodium Chloride, Dietary / Q000494:pharmacology*; D013654:Taurine / Q000494:pharmacology*
chemical_list: D015220:Calcium Channels; D017673:Sodium Chloride, Dietary; D013654:Taurine; D009638:Norepinephrine; D004837:Epinephrine