More kapakahines from the marine sponge Cribrochalina olemda.
Three new kapakahines E-G (1-3) have been isolated from the marine sponge Cribrochalina olemda. Limited quantities of these compounds required not only NMR analysis but also FAB-MS/MS analysis for the structure elucidation. Kapakahine E showed cytotoxicity against P388 murine leukemia cells. [structure: see text]
Nakao
Yoichi
Y
Department of Chemistry, University of Hawai'i at Manoa, 2545 The Mall, Honolulu, Hawaii 96822-2275, USA. ayocha@mail.ecc.u-tokyo.ac.jp
Kuo
Jacqueline
J
Yoshida
Wesley Y
WY
Kelly
Michelle
M
Scheuer
Paul J
PJ
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C476162:kapakahine E; C476160:kapakahine F; C476161:kapakahine G