title: Pulmonary manifestations in brucellosis: a report on seven cases from Bikaner (north-west India).
abstract: OBJECTIVE
  Pulmonary manifestations of Brucellosis are rare. We came across seven patients with predominant symptomatology of pulmonary involvement amongst 98 patients of active brucellosis seen in last four years.
  
  
  METHODS
  The study is related to patients of brucellosis whose principal presenting features were related to respiratory symptom (cough, expectoration, pain in chest and breathlessness) along with fever and other constitutional symptoms. It included seven patients amongst 98 patients of active brucellosis seen during June 1996 to Feb. 2000 at PBM Hospital Bikaner. Diagnosis was confirmed by demonstration of the raised brucella agglutination titre of 1:320 or more in the serum. All patients were treated with rifampicin 900 mg daily and doxycyclin 100 mg twice daily for six week. The treatment was extended for another four weeks in two patients because of persistence of skiagram abnormalities.
  
  
  RESULTS
  Three patients had abnormality in skiagram chest in the form of pleural effusion, multiple paranchymal opacities and pneumonia. The skiagram chest was normal in remaining four patients. The response of treatment started with 10-15 days and all the patients became symptom-free at the end of six weeks except one patient. Skiagram chest at this time was normal in patients of pleural effusion but there was persistence of haziness and few opacities in other two patients. Follow up skiagram chest at the end of six months and twelve months was normal in all patients except calcified opacity in one patient. There was no evidence of relapse in any patient at the end of one year follow up. Liver function tests remained within normal range and no drug toxicity was observed.
  
  
  CONCLUSIONS
  Pulmonary manifestations of brucellosis are rare. Treatment with rifampicin and doxycylin showed marked clinical and radiological improvement. All patients were completely disease-free at the end of one year follow up.
authors.affiliation: Department of Medicine, SP Medical College, Bikaner (Rajasthan).
authors.forename: D K
authors.initials: DK
authors.lastname: Kochar
authors.forename: B V
authors.initials: BV
authors.lastname: Sharma
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: R
authors.initials: R
authors.lastname: Jain
authors.forename: L A
authors.initials: LA
authors.lastname: Gauri
authors.forename: T
authors.initials: T
authors.lastname: Srivastava
mesh_terms: D000293:Adolescent; D000328:Adult; D002006:Brucellosis / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D004318:Doxycycline / Q000627:therapeutic use; D006801:Humans; D007194:India; D008171:Lung Diseases / Q000503:physiopathology; D008297:Male; D016273:Occupational Exposure; D012293:Rifampin / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D004318:Doxycycline; D012293:Rifampin