Translocation (1;4)(p31;q34) in nonossifying fibroma.
Nonossifying fibroma is a benign, lytic lesion of fibrous origin most often observed in the metaphyseal region of the long bones in children and adolescents. It is frequently asymptomatic and is often characterized by a history of spontaneous resolution. Herein, we report a clinicohistopathologically typical case of nonossifying fibroma arising in the tibia of an 18-year-old skeletally mature female. Conventional cytogenetic analysis revealed a reciprocal translocation involving bands 1p31 and 4q34 [t(1;4)(p31;q34)]. To the best of our knowledge, this is only the second reported case of a clonally aberrant nonossifying fibroma.
Nelson
Marilu
M
Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA.
Perry
Deborah
D
Ginsburg
Glen
G
Sanger
Warren G
WG
Neff
James R
JR
Bridge
Julia A
JA
D000293:Adolescent; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005260:Female; D005350:Fibroma / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D007717:Knee / Q000473:pathology; D014178:Translocation, Genetic / Q000235:genetics*