title: Effect of particle size on the adsorption of theophylline onto activated charcoal, in vitro study.
abstract: The effective use of activated charcoal as oral adsorbent in the primary treatment of acute theophylline poisoning was studied in vitro. Adsorption capacities for theophylline onto activated charcoal of varying particle size were investigated. No difference in the equilibrium amount of theophylline adsorbed onto activated charcoal was recognized. This result could be explained by the physical properties of activated charcoal. The amount of theophylline adsorbed from physiological saline solution was greater than that from water. The smaller the particle size of activated charcoal, the faster theophylline was adsorbed. It was assumed that the increase of contact area by grounding activated charcoal of large particle size accelerated the adsorption of theophylline onto activated charcoal.
authors.affiliation: School of Pharmaceutical Sciences, Kinki University.
authors.forename: Takeo
authors.initials: T
authors.lastname: Nakamura
authors.forename: Naohito
authors.initials: N
authors.lastname: Kawasaki
authors.forename: Kazuoki
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Seiki
authors.initials: S
authors.lastname: Tanada
mesh_terms: D000327:Adsorption; D002606:Charcoal; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D066298:In Vitro Techniques; D010316:Particle Size; D012965:Sodium Chloride; D013806:Theophylline
chemical_list: D002606:Charcoal; D012965:Sodium Chloride; D013806:Theophylline