Gene expression profiles of human breast cancer progression.
Although distinct pathological stages of breast cancer have been described, the molecular differences among these stages are largely unknown. Here, through the combined use of laser capture microdissection and DNA microarrays, we have generated in situ gene expression profiles of the premalignant, preinvasive, and invasive stages of human breast cancer. Our data reveal extensive similarities at the transcriptome level among the distinct stages of progression and suggest that gene expression alterations conferring the potential for invasive growth are already present in the preinvasive stages. In contrast to tumor stage, different tumor grades are associated with distinct gene expression signatures. Furthermore, a subset of genes associated with high tumor grade is quantitatively correlated with the transition from preinvasive to invasive growth.
Ma
Xiao-Jun
XJ
Applied Genomics Division, Arcturus, 2715 Loker Avenue West, Carlsbad, CA 92008, USA.
Salunga
Ranelle
R
Tuggle
J Todd
JT
Gaudet
Justin
J
Enright
Edward
E
McQuary
Philip
P
Payette
Terry
T
Pistone
Maria
M
Stecker
Kimberly
K
Zhang
Brian M
BM
Zhou
Yi-Xiong
YX
Varnholt
Heike
H
Smith
Barbara
B
Gadd
Michelle
M
Chatfield
Erica
E
Kessler
Jessica
J
Baer
Thomas M
TM
Erlander
Mark G
MG
Sgroi
Dennis C
DC
D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D018450:Disease Progression; D004798:Enzymes / Q000235:genetics; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017403:In Situ Hybridization; D009363:Neoplasm Proteins / Q000235:genetics; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction
D004798:Enzymes; D009363:Neoplasm Proteins