title: Bone mineral density in an outpatient population receiving enzyme-inducing antiepileptic drugs.
abstract: Antiepileptic drug (AED) use is identified as being associated with increased fracture risk. AEDs commonly associated with osteopathies are inducers of the hepatic cytochrome p450 enzyme system (EIAEDs). We performed a retrospective cross-sectional study assessing bone mineral density (BMD) in an adult outpatient population receiving EIAEDs. Patients were routinely referred for dual-energy X-ray absorptiometry to evaluate BMD. BMD was measured at the femoral neck of hip and lumbar spine. Results were presented as absolute BMD (g/cm(2)), T score, and Z score. T and Z scores were used in this analysis. As a group, those with BMD measurements represent people with intractable epilepsy. There were no statistically significant differences found in the T or Z scores by gender; therefore all analyses combined both men and women. Significant reductions in both T and Z scores were present in men and women <50 and >or=50.
authors.affiliation: Department of Neurology, Columbia University, New York, NY 10032, USA. ap390@columbia.edu
authors.forename: Alison M
authors.initials: AM
authors.lastname: Pack
authors.forename: Lucia S
authors.initials: LS
authors.lastname: Olarte
authors.forename: Martha J
authors.initials: MJ
authors.lastname: Morrell
authors.forename: Edith
authors.initials: E
authors.lastname: Flaster
authors.forename: Stanley R
authors.initials: SR
authors.lastname: Resor
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Shane
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use*; D015519:Bone Density / Q000502:physiology*; D003430:Cross-Sectional Studies; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013131:Spine / Q000000981:diagnostic imaging*
chemical_list: D000927:Anticonvulsants; D003577:Cytochrome P-450 Enzyme System