Cytotoxic effect of low-density lipoproteins.
The cytopathogenic effect of various modified lipoproteins on cultured peritoneal macrophages was studied in vitro. After minor peroxide modification lipoproteins induced apoptosis of macrophages. Immune complexes containing oxidized lipoproteins caused cell necrosis.
Nagornev
V A
VA
Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg. van@iem.spb.ru
Voskan'yants
A N
AN
Vinogradov
A G
AG
Zhdanova
O Yu
OY
Denisenko
A D
AD
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D017209:Apoptosis; D001323:Autoantibodies / Q000276:immunology; D002478:Cells, Cultured; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000276:immunology* / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000276:immunology* / Q000378:metabolism; D008297:Male; D051379:Mice
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D008077:Lipoproteins, LDL