Missing genes in metabolic pathways: a comparative genomics approach.
The new techniques of genome context analysis--chromosomal gene clustering, protein fusions, occurrence profiles and shared regulatory sites--infer functional coupling between genes. In combination with metabolic reconstructions, these techniques can dramatically accelerate the pace of gene discovery.
Osterman
Andrei
A
Integrated Genomics, Inc., 2201 W. Campbell Park Drive, Chicago, IL 60612, USA. andrei@integreatedgenomics.com
Overbeek
Ross
R
D000818:Animals; D004798:Enzymes / Q000235:genetics* / Q000378:metabolism*; D023281:Genomics; D006801:Humans; D005810:Multigene Family / Q000235:genetics
D004798:Enzymes