title: Disodium octaborate tetrahydrate (DOT) application and vacuum cleaning, a combined strategy to control house dust mites.
abstract: BACKGROUND
  The effectiveness of acaricides in homes is controversial.
  
  
  OBJECTIVE
  To determine whether disodium octaborate tetrahydrate (DOT) combined with vacuuming lowers dust mite numbers and their allergens in carpets and sofas.
  
  
  METHODS
  A 6-month study was carried out with 93 homes, which were randomized into three groups: (i). active, received DOT; (ii). placebo, received water; and (iii). control, received no application. Active and placebo homes were vacuumed weekly. Dust was collected from carpets and sofas at the start of the study and every 2 months thereafter and quantified for live, total mites, and mite allergen levels.
  
  
  RESULTS
  At 2 months, live mite numbers in active carpets were 3 +/- 1, in placebo carpets 129 +/- 48, and in control carpets 177 +/- 39 mites/g. The corresponding numbers in sofas were 3 +/- 2, 81 +/- 31, and 134 +/- 45 mites/g, respectively (P < 0.001 active vs placebo and vs. control). Live mites in carpets and sofas remained lower in the active group at 6 months (P < 0.001). Total mites in active carpets decreased from 555 +/- 69 at baseline to 223 +/- 32 mites/g at 6 months (P < 0.001) and mite allergen levels from 1.36 +/- 0.13 to 0.85 +/- 0.16 microg/g (P < 0.001). Total mites in active sofas remained unchanged, but mite allergen levels decreased from 1.48 +/- 0.25 at baseline to 0.7 +/- 0.15 microg/g at month 6 (P < 0.05).
  
  
  CONCLUSIONS
  DOT kills mites in carpets and sofas, and, combined with vacuuming, effectively reduces total mites in carpets and mite allergen levels in carpets and sofas.
authors.affiliation: Department of Medicine, University of South Florida College of Medicine and James A Haley VA Hospital, Tampa, FL 33612-4745, USA.
authors.forename: R
authors.initials: R
authors.lastname: Codina
authors.forename: R F
authors.initials: RF
authors.lastname: Lockey
authors.forename: R
authors.initials: R
authors.lastname: Diwadkar
authors.forename: L L
authors.initials: LL
authors.lastname: Mobly
authors.forename: S
authors.initials: S
authors.lastname: Godfrey
mesh_terms: D000818:Animals; D001881:Borates / Q000008:administration & dosage*; D004311:Double-Blind Method; D005430:Floors and Floorcoverings; D006796:Household Work; D007374:Interior Design and Furnishings; D010043:Outcome and Process Assessment, Health Care; D010571:Pest Control / Q000379:methods*; D039981:Pyroglyphidae
chemical_list: D001881:Borates; C077054:disodium octaborate tetrahydrate