Double-chelation-assisted Rh-catalyzed intermolecular hydroacylation.
[reaction: see text] Rh-Catalyzed intermolecular hydroacylation between salicylaldehydes and 1,5-hexadienes proceeded under remarkably mild reaction conditions to afford a mixture of iso- and normal-hydroacylated products in good yields. The experiments using deuterated salicylaldehyde-d revealed that "double chelation" of salicylaldehyde and 1,5-hexadiene to Rh-complex played vital roles in the catalytic cycle of intermolecular hydroacylation.
Tanaka
Masakazu
M
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan. mtanaka@phar.kyushu-u.ac.jp
Imai
Masanori
M
Yamamoto
Yoichiro
Y
Tanaka
Keitaro
K
Shimowatari
Masato
M
Nagumo
Shinji
S
Kawahara
Norio
N
Suemune
Hiroshi
H