Growth hormone-insulin-like growth factor-1 axis, leptin and sleep in anorexia nervosa patients.
The present study characterizes the relationships between severe malnutrition, sleep, growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis, and leptin levels in anorexia nervosa (AN) patients before and after weight gain. Eleven restricting-type anorectic females (mean age = 19.7 years) with severe starvation state [mean body mass index (BMI) = 13.3] were studied using polysomnography and spectral power analysis. The hormone levels were measured in the morning after sleep recording. Eleven normal-weight, age- and gender-matched healthy volunteers without a history of any eating disorder served as controls. After nutritional treatment for about 2 months (65.7 +/- 6.4 days), sleep examinations and blood tests were repeated. At this stage, the study group consisted of 5 patients (mean BMI = 15.6). Higher IGF-1 and leptin levels were associated with longer and deeper sleep among anorectics. The sleep parameters including the percentages of stage 1 sleep and SWS as well as IGF-1 tended to normalize after only limited weight gain. Sleep disturbances in anorectics may be mediated through changes in the levels of the GH-IGF-1 axis hormones, as well as the levels of leptin.
Lindberg
Nina
N
Department of Psychiatry, University of Helsinki, Helsinki, Finland. nina.lindberg@pp3.inet.fi
Virkkunen
Matti
M
Tani
Pekka
P
Appelberg
Björn
B
Rimón
Ranan
R
Porkka-Heiskanen
Tarja
T
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000856:Anorexia Nervosa / Q000378:metabolism* / Q000503:physiopathology; D015992:Body Mass Index; D004569:Electroencephalography / Q000379:methods; D005260:Female; D015200:Fluoroimmunoassay / Q000379:methods; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism*; D016011:Normal Distribution; D017286:Polysomnography / Q000379:methods; D011863:Radioimmunoassay / Q000379:methods; D012890:Sleep / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology; D018709:Statistics, Nonparametric
D020738:Leptin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone