title: V gamma 9V delta 2 T-cell anergy and complementarity-determining region 3-specific depletion during paroxysm of nonendemic malaria infection.
abstract: V gamma 9V delta 2 T lymphocytes strongly respond to phosphoantigens from Plasmodium parasites. Thus, we analyzed the changes in V gamma 9V delta 2 T-cell function and repertoire during the paroxysm phase of nonendemic malaria infection. During malaria paroxysm, V gamma 9V delta 2 T cells were early activated but rapidly became anergic and finally loose J gamma 1.2 V gamma 9 complementarity-determining region 3 transcripts.
authors.affiliation: Laboratory of Clinical Pathology, National Institute for Infectious Diseases Lazzaro Spallanzani I.R.C.C.S., Rome, Italy. martini@inmi.it
authors.forename: Federico
authors.initials: F
authors.lastname: Martini
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Paglia
authors.forename: Carla
authors.initials: C
authors.lastname: Montesano
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Enders
authors.forename: Marco
authors.initials: M
authors.lastname: Gentile
authors.forename: C David
authors.initials: CD
authors.lastname: Pauza
authors.forename: Cristiana
authors.initials: C
authors.lastname: Gioia
authors.forename: Vittorio
authors.initials: V
authors.lastname: Colizzi
authors.forename: Pasquale
authors.initials: P
authors.lastname: Narciso
authors.forename: Leopoldo Paolo
authors.initials: LP
authors.lastname: Pucillo
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Poccia
mesh_terms: D000328:Adult; D022801:Complementarity Determining Regions / Q000235:genetics*; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007108:Immune Tolerance; D016778:Malaria, Falciparum / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics / Q000502:physiology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D022801:Complementarity Determining Regions; D006684:HLA-DR Antigens; D016692:Receptors, Antigen, T-Cell, gamma-delta