title: Low dose sultamicillin in acute sinusitis.
abstract: OBJECTIVE
  To study the effectiveness of low dose sultamicillin in the treatment of acute sinusitis.
  
  
  METHODS
  A total of 108 patients, between 16-56 years of age (mean 32.8), suffering from acute sinusitis took part in the trial. Patients received orally 2 x 375 mg sultamicillin, and compared with patients receiving 3 x 500 mg amoxicillin. The first control was made between the 5th and 7th days. A patient was considered clinically cured when all pretreatment signs and symptoms of infection were eliminated. Clinical improvement was defined as the partial disappearance of pretreatment signs and symptoms. In either result, study drugs were reconstituted for additional 5 days. Failure was defined as no change or worsening of signs and symptoms; and study drug was changed. The second control was made between 10-12th days, and the third was four weeks later.
  
  
  RESULTS
  The clinical success (improvement + cure) rate was (17+11)/42 (66.6%) and (28+21)/66 (74.2%) for amoxicillin and sultamicillin respectively, at first control. All improved patients were cured at the second control. No significant side-effects were noted in either amoxicillin or sultamicillin treated patients. All side effects were gastrointestinal, 11.9% and 3.0% in the same order.
  
  
  CONCLUSIONS
  Low dose sultamicillin was comparable to amoxicillin; sultamicillin has fewer side effects than amoxicillin (p>0.05).
authors.affiliation: Department of Otolaryngology, School of Medicine, Pamukkale University, Denizli, Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Topuz
authors.forename: Orhan
authors.initials: O
authors.lastname: Katircioğlu
authors.forename: Ismet
authors.initials: I
authors.lastname: Bayramoğlu
authors.forename: Fazil Nejdet
authors.initials: FN
authors.lastname: Ardiç
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Erbudak
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage*; D000667:Ampicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method; D012852:Sinusitis / Q000188:drug therapy*; D013407:Sulbactam / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; C035444:sultamicillin; D000667:Ampicillin; D000658:Amoxicillin; D013407:Sulbactam