[Gastric MALT lymphoma, a malignancy potentially curable by eradication of Helicobacter pylori].
Gastric MALT lymphoma is the most prevalent low-grade marginal zone lymphoma. It is now well demonstrated that gastric MALT lymphoma is strongly related to Helicobacter pylori infection. Prolonged remission of lymphoma is achieved in more than 50% of patients after Helicobacter pylori eradication. Two factors of tumor response were found: presence of perigastric lymph nodes at endoscopic ultrasonography was related to a failure in 2 out of 3 patients; presence of a translocation t (11; 18) with the fusion of two genes implicated in B lymphocytes apoptosis was related to a failure in most of patients. Further studies are needed to determine the most adapted treatment in non-responding patients. A long-term endoscopic follow-up is recommended due to the increased risk of gastric adenocarcinoma in spite of Helicobacter pylori eradication.
Delchier
Jean-Charles
JC
Service d'Hépato-Gastroentérologie, Hôpital Henri-Mondor, 94010 Créteil Cedex. jean-charles.delchier@hmn.ap-hop-paris.fr
D016099:Endoscopy, Gastrointestinal; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000188:drug therapy* / Q000382:microbiology*; D008991:Monitoring, Physiologic; D011379:Prognosis; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000382:microbiology*; D016896:Treatment Outcome; D014463:Ultrasonography
Le lymphome gastrique du MALT, une infection maligne potentiellement curable par l'éradication de Helicobacter pylori.