title: Accuracy of magnetic resonance imaging in determining cause of sudden death in adults: comparison with conventional autopsy.
abstract: OBJECTIVE
  To determine the accuracy and define the limitations of post mortem magnetic resonance imaging (MRI) in determining the cause of sudden death in adults.
  
  
  RESULTS
  Sudden unexpected adult deaths in the community, reported to the Coroner (n = 10), excluding suspicious, violent or potentially drug-related deaths, were submitted to whole body MRI, followed by full invasive autopsy. The MRI scans were reported independently by four radiologists, blinded to the autopsy findings; two had previous experience of post mortem MRI. An abnormality that related to the cause of death as identified at autopsy, was identified by at least one radiologist in eight cases. These were pulmonary consolidation (autopsy finding pneumonia) (n = 1), pneumoperitoneum (autopsy finding perforated peptic ulcer) (n = 2), left ventricular failure (autopsy finding ischaemic heart disease) (n = 4), and disseminated bronchial carcinoma (n = 1). However, in only one case were all radiologists able to provide a confident cause of death (disseminated bronchial carcinoma). In two cases, in which death occurred 2-6 days and 3-6 days before MRI, early decomposition prevented interpretation of the images. Severe coronary artery atheroma was detected at autopsy in 7/10, but these lesions were not detected by MRI. Previous experience in reporting post mortem MRI, without autopsy comparison, did not result in more accurate interpretation of the images.
  
  
  CONCLUSIONS
  This pilot study suggests that post mortem MRI can identify some abnormalities relating to the common causes of sudden death in adults, but there is a need for greater experience in correlating MRI with autopsy findings before a reliable cause of death can be made by MRI alone. Inability to image coronary artery lesions, differentiating thrombus from clot and pulmonary oedema from pneumonic exudates, are specific problems that may be corrected with greater experience and higher resolution scans.
authors.affiliation: Department of Cellular Pathology, Oxford Radcliffe Hospitals, UK. ian.roberts@orh.nhs.uk
authors.forename: I S D
authors.initials: IS
authors.lastname: Roberts
authors.forename: E W
authors.initials: EW
authors.lastname: Benbow
authors.forename: R
authors.initials: R
authors.lastname: Bisset
authors.forename: J P R
authors.initials: JP
authors.lastname: Jenkins
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Reid
authors.forename: A
authors.initials: A
authors.lastname: Jackson
mesh_terms: D000328:Adult; D001344:Autopsy / Q000379:methods*; D002423:Cause of Death; D003645:Death, Sudden / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D010865:Pilot Projects; D015203:Reproducibility of Results; D016037:Single-Blind Method