[Expression of adhesion molecules LFA-1 and L-selectin on PMN and level of soluble sE-selectin and sL-selectin in the serum of patients with small cell lung cancer].
The aim of this study was to estimate expression of adhesion molecules LFA-1 and L-selectin on PMN of peripheral blood, and level of soluble sE-selectin and sL-selectin in the serum of 16 patients with small cell lung cancer (SCLC) before treatment. We observed significantly higher expression of LFA-1 and L-selectin on PMN in comparison to healthy persons and higher level sE selectin and sL selectin in the serum of SCLC patients. Increasing of adhesion molecules expression on PMN can lead to damage of neoplasmatic cells and may be one of the reasons for create a new cancer sites as well.
Izycka
Aneta
A
Zakład Immunologii AM, Białymstoku. anetaiz@mp.pl
Jabłońska
Ewa
E
Izycki
Tomasz
T
Chyczewska
Elzbieta
E
D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology*; D016022:Case-Control Studies; D002448:Cell Adhesion; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D019041:L-Selectin / Q000097:blood*; D008175:Lung Neoplasms / Q000276:immunology*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D018709:Statistics, Nonparametric
D019040:E-Selectin; D016169:Lymphocyte Function-Associated Antigen-1; D019041:L-Selectin
Ocena ekspresji czasteczek adhezyjnych LFA-1 i L-selektyny na neutrofilach krwi obwodowej oraz poziomu rozpuszczalnych form L-selektyny i E-selektyny u chorych na drobnokomórkowego raka płuca.