title: [Changes in plasma zinc and folic acid concentrations in pregnant adolescents submitted to different supplementation regimens].
abstract: Zinc and folic acid nutritional status was evaluated in 74 low-income pregnant adolescents ranging from 13 to 18 years of age who received prenatal care at the Evangelina Rosa Maternity Hospital in Teresina, Piau State, Brazil. In order to evaluate the effects of different supplementation regimens on nutritional status, the adolescents were distributed into five groups. Groups I and II received equal amounts of folic acid (250 micro;g) and different doses of iron (ferrous sulfate), 120 and 80 mg, respectively. Groups III and IV received equal amounts of folic acid (250 micro;g) associated with zinc sulfate and iron at doses of 120 and 80 mg, respectively, while group V received only 120 mg of iron (routine dosage). There was a reduction in the zinc plasma concentration, and this decline was significant only in those groups which did not receive zinc supplementation. In relation to combination iron/folic acid and iron/folic acid/zinc, an excellent response was observed for folic acid, and this effect was larger in the groups that received folic acid combined with zinc, suggesting a possible role for zinc in folic acid metabolism.
authors.affiliation: Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal do Piauí, Teresina, PI, 64049-550, Brasil. nadirn@uol.com.br
authors.forename: Nadir do Nascimento
authors.initials: Ndo N
authors.lastname: Nogueira
authors.forename: Joaquim Vaz
authors.initials: JV
authors.lastname: Parente
authors.forename: Sílvia Maria Franciscato
authors.initials: SM
authors.lastname: Cozzolino
mesh_terms: D000293:Adolescent; D001938:Brazil; D019587:Dietary Supplements; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D007501:Iron / Q000008:administration & dosage; D008137:Longitudinal Studies; D009752:Nutritional Status; D011247:Pregnancy; D011253:Pregnancy in Adolescence / Q000097:blood*; D011446:Prospective Studies; D016037:Single-Blind Method; D015032:Zinc / Q000097:blood*; D019287:Zinc Sulfate / Q000008:administration & dosage
chemical_list: D019287:Zinc Sulfate; D005492:Folic Acid; D007501:Iron; D015032:Zinc
vernacular_title: Mudanças na concentração plasmática de zinco e ácido fólico em adolescentes grávidas submetidas a diferentes esquemas de suplementação.