Antiatherogenic effect of taurine in high fat diet fed rats.
The role of taurine on atherogenesis induced by high fat diet in rats, a species which depends entirely on taurine for conjugation of bile acids has been investigated. Wistar male rats were fed on (p.o.) taurine in addition to high fat diet (11% coconut oil w/w) for 6 months. High fat diet caused significant increase of serum total cholesterol (2 fold), serum triglycerides (92.6%), LDL cholesterol (92.3%) and body weight gain (2.8 fold). Taurine administration significantly reduced serum cholesterol (37%), triglycerides (94.5%), LDL cholesterol (34%), body weight (46%). It also significantly reduced aortic cholesterol and thiobarbituric acid reactive substances and there was a significant increase of reduced glutathione. Taurine significantly increased fecal bile acids which may have resulted in significant decrease of serum cholesterol. Aortic lesion index was significantly decreased in the taurine administered group suggesting the antiatherogenic effect of taurine. It is concluded that taurine attenuated the atherogenesis possibly by its hypocholesterolemic and antioxidant property.
Sethupathy
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S
Division of Biochemistry, Rajah Muthiah Medical College, Annamalai University, Annamalai Nagar 608 002, India. drsethupathy@rediffmail.com
Elanchezhiyan
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C
Vasudevan
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Rajagopal
G
G
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood / Q000145:classification; D004041:Dietary Fats / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D004041:Dietary Fats; D014280:Triglycerides; D013654:Taurine; D002784:Cholesterol