title: [A case of Fahr's disease presenting "diffuse neurofibrillary tangles with calcification"].
abstract: 77-year-old woman presented memory disturbance, hallucination, and personality change since the summer of 1988. Laboratory findings revealed normal serum Ca, P, HS-PTH levels and Ellsworth-Howard test was intact. Neuroradiological studies disclosed calcification in the dentate nucleus, putamen, globus pallidus and thalamus. We made a diagnosis of Fahr's disease. During the follow-up period of 13 years, brain MRI showed gradual atrophy in temporal lobes. This case was characterized by the clinical and neuroradiological findings of "diffuse neurofibrillary tangles with calcification: DNTC". We discussed the relations of Fahr's disease and DNTC in the literatures. From our long time observation of this case, we suggest that Fahr's disease includes DNTC.
authors.affiliation: Fourth Department of Internal Medicine, Toho University School of Medicine.
authors.forename: Nobuatsu
authors.initials: N
authors.lastname: Nomoto
authors.forename: Hideki
authors.initials: H
authors.lastname: Sugimoto
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Iguchi
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Kurihara
authors.forename: Nobuo
authors.initials: N
authors.lastname: Wakata
mesh_terms: D000368:Aged; D001284:Atrophy; D001480:Basal Ganglia Diseases / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002114:Calcinosis / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D016874:Neurofibrillary Tangles / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology; D013997:Time Factors