title: Chronological alterations of calbindin D-28k immunoreactivity in the gerbil main olfactory bulb after ischemic insult.
abstract: We investigated spatial and temporal alterations of calbindin D-28k (CB) immunoreactivity in the gerbil main olfactory bulb after transient ischemia-reperfusion. In sham-operated animals, CB-immunoreactive (IR) neurons were found in the periglomerular layer, external plexiform layer and granule cell layer. At 1-4 days after ischemic insult, the number of CB-IR neurons significantly increased. This result suggests that the increased CB may buffer the intracellular calcium at an early time point after the ischemic insult. In contrast, 10-30 days after the ischemic insult, the number of CB-IR neurons significantly decreased as compared to sham-operated animals. This result suggests that a malfunction in olfactory process may have occurred in the olfactory bulb at a later time point after the ischemic insult.
authors.affiliation: Department of Anatomy, College of Medicine, Hallym University, Chunchon 200-702, South Korea.
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Tae-Cheon
authors.initials: TC
authors.lastname: Kang
authors.forename: Jae Chul
authors.initials: JC
authors.lastname: Lee
authors.forename: Seung-Kook
authors.initials: SK
authors.lastname: Park
authors.forename: Sung Jin
authors.initials: SJ
authors.lastname: An
authors.forename: In Se
authors.initials: IS
authors.lastname: Lee
authors.forename: Yoon-Bok
authors.initials: YB
authors.lastname: Lee
authors.forename: Heon-Soo
authors.initials: HS
authors.lastname: Sohn
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Kang
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Choi
authors.forename: Moo Ho
authors.initials: MH
authors.lastname: Won
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D064026:Calbindins; D004195:Disease Models, Animal; D005849:Gerbillinae; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D009830:Olfactory Bulb / Q000378:metabolism* / Q000473:pathology*; D015427:Reperfusion Injury / Q000378:metabolism* / Q000473:pathology; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D013997:Time Factors
chemical_list: D064026:Calbindins; D064030:S100 Calcium Binding Protein G