The effect of the cyclooxygenase blockers, ibuprofen on the development of glomeruli in Sprague-Dawley rats.
Cyclo-oxygenase mediated prostaglandins are important determinants of glomerular development and kidney function. Ibuprofen inhibit the enzyme cyclo-oxygenase and thereby block the prostaglandin synthesis in the kidneys. Cyclo-oxygenase exist in two iso-forms (COX-1 and COX-2). It has ben proposed that Non-steroidal anti-inflammatory drugs (NSAIDs) with preferential COX-2 selectivity have fewer renal side effects than drugs with preferential COX-1 selectivity. The significance of this remains unclear since nephrotoxicity is relatively uncommon with ibuprofen and, when present is usually rapidly reversible although, ibuprofen has a higher potency against COX-1 than COX-2. We therefore investigated the effect of ibuprofen on glomerulogenesis in Sprague-Dawley rats. Ibuprofen (22 mg/kg/day) was administered orally from day 10 of gestation to day 15 after parturition. Light microscopic examination of ibuprofen-treated neonatal kidneys show hypoplastic glomeruli. These results suggest that low dose ibuprofen is deleterious to glomerular development.
Akinola
O
O
Department of Anatomy, College of Medicine, University of Lagos, P.M.B. 12003, Lagos, Nigeria.
Noronha
C
C
Oremosu
A
A
Kusemiju
O
O
Okanlawon
O A
OA
D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D005260:Female; D007052:Ibuprofen / Q000009:adverse effects*; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000201:enzymology* / Q000473:pathology; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley
D016861:Cyclooxygenase Inhibitors; D007052:Ibuprofen