The association of antibodies against oxidized low-density lipoprotein with atherosclerosis in hemodialysis patients.
BACKGROUND
Immune response to oxidized low-density lipoprotein (oxLDL) may modulate atherogenesis. We recently reported that a high titer of serum anti-oxLDL antibody was an independent predictor of a low risk for cardiovascular death in patients with end-stage renal disease (ESRD). In the present study, we examined a possible association between anti-oxLDL antibody titer and arterial wall thickness in ESRD patients.


METHODS
The subjects were 103 ESRD patients treated with hemodialysis. A high resolution B-mode ultrasound method was used to measure intima-media thickness of carotid (CA-IMT) and femoral arteries (FA-IMT).


RESULTS
In univariate analysis, anti-oxLDL antibody showed a significant negative correlation with FA-IMT. The inverse association between anti-oxLDL antibody and FA-IMT remained significant in multiple regression analysis, including age, gender, blood pressure, plasma lipids, smoking, C-reactive protein, calcium-phosphate product, serum albumin, body mass index, and duration of dialysis as covariates. The antibody titer showed an inverse trend with CA-IMT without statistical significance.


CONCLUSIONS
These results show for the first time that titer of anti-oxLDL antibody is an independent factor inversely associated with arterial thickness in ESRD, supporting the concept that immunity against oxLDL plays an anti-atherogenic role.
Shoji
Tetsuo
T
Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan. t-shoji@med.osaka-cu.ac.jp
Kimoto
Eiji
E
Shinohara
Kayo
K
Emoto
Masanori
M
Ishimura
Eiji
E
Miki
Takami
T
Tsujimoto
Yoshihiro
Y
Tabata
Tsutomu
T
Nishizawa
Yoshiki
Y
D000328:Adult; D001161:Arteriosclerosis / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000276:immunology* / Q000628:therapy; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D006435:Renal Dialysis; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology
D001323:Autoantibodies; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein