title: [Serum anti-P53 antibodies (AB-anti-P53) in patients with advanced non-small cell lung cancer (NSCLC)].
abstract: The aim of the study was to assess the frequency of serum Ab-anti-p53 in 39 patients with advanced NSCLC and to evaluate the predictive value of the test. Antibodies were present in 10 (25.6%) of patients. There was no correlation between Ab-anti-p53 and clinical characteristics including age, gender, and histological type of tumor. In 17 patients response to chemotherapy (CT) was obtained (in one patient--complete, and in 16--partial response). The percentage of patients responding to CT in group with and without serum antibodies did not differ significantly (33% and 48%, respectively; p = 0.48). The results of the study indicate that serum Ab-anti-p53 are relatively often present in advanced NSCLC patients, however the clinical value of this test needs further evaluation.
authors.affiliation: Klinika Chorób Płuc i Gruźlicy AM, Gdańsku.
authors.forename: Marcin
authors.initials: M
authors.lastname: Skrzypski
authors.forename: Amelia
authors.initials: A
authors.lastname: Szymanowska
authors.forename: Anna
authors.initials: A
authors.lastname: Janowicz
authors.forename: Rafał
authors.initials: R
authors.lastname: Dziadziuszko
authors.forename: Rodryg
authors.initials: R
authors.lastname: Ramlau
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kozielski
authors.forename: Anna
authors.initials: A
authors.lastname: Pilarska-Machowicz
authors.forename: Zuzanna
authors.initials: Z
authors.lastname: Dobrzańska
authors.forename: Jacek
authors.initials: J
authors.lastname: Bigda
authors.forename: Maciej
authors.initials: M
authors.lastname: Krzakowski
authors.forename: Ewa
authors.initials: E
authors.lastname: Jassem
authors.forename: Jacek
authors.initials: J
authors.lastname: Jassem
mesh_terms: D000328:Adult; D000368:Aged; D000912:Antibodies, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*
chemical_list: D000912:Antibodies, Neoplasm; D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53
vernacular_title: Wystepowanie przeciwciał przeciw białku p53 w surowicy chorych na zaawansowanego niedrobnokomórkowego raka płuca. Doniesienie wstepne.