Selective binding of steroids by 2,2'-biquinoline-4,4'-dicarboxamide-bridged bis(beta-cyclodextrin): fluorescence enhancement by guest inclusion.
A novel bis(beta-cyclodextrin) was synthesized, and its binding behavior with steroids was investigated to demonstrate that the cooperative co-inclusion of guest and tether by two cyclodextrin moieties is operative to afford the highest molecular selectivity of up to 3.6 for deoxycholate over taurocholate.
Liu
Yu
Y
Department of Chemistry and State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China. yuliu@public.tpt.tj.cn
Song
Yun
Y
Wang
Hao
H
Zhang
Heng-Yi
HY
Wada
Takehiko
T
Inoue
Yoshihisa
Y
D001665:Binding Sites; D002942:Circular Dichroism; D003505:Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D011804:Quinolines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013256:Steroids / Q000737:chemistry*; D013656:Taurocholic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D007202:Indicators and Reagents; D011804:Quinolines; D013256:Steroids; D047392:beta-Cyclodextrins; D013656:Taurocholic Acid; C031215:betadex