Possible mechanism underlying the antiarrhythmic effect of peptides nociceptin and DALDA on the heart.
During aconitine-induced arrhythmias the antiarrhythmic effect of DALDA (Tyr-D-Arg-Phe-Lys-NH2) and nociceptin (orphanin FQ) administered intravenously depended on activation of nitric oxide synthase. K(ATP) channels were not involved in the realization of this effect. Endogenous prostanoids played a minor role in the antiarrhythmic effect of nociceptin and did not contribute to the protective influence of DALDA. The antiarrhythmic effect of orphanin FQ administered intravenously did not depend on functional activity of the autonomic nervous system. However, the effect of orphanin FQ after intracerebroventricular infusion was determined by changes in the state of this system.
Lishmanov
Yu B
YB
Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Maslov
L N
LN
Krylatov
A V
AV
Solenkova
N V
NV
Stakheev
D L
DL
D000157:Aconitine / Q000633:toxicity; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000201:enzymology; D004562:Electrocardiography; D005905:Glyburide / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000378:metabolism; D009842:Oligopeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D018847:Opioid Peptides / Q000008:administration & dosage / Q000627:therapeutic use*; D015221:Potassium Channels / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000097629:Nociceptin
D000157:Aconitine; D000889:Anti-Arrhythmia Agents; D005905:Glyburide; D007213:Indomethacin; D019331:NG-Nitroarginine Methyl Ester; D019001:Nitric Oxide Synthase; D009842:Oligopeptides; D018847:Opioid Peptides; D015221:Potassium Channels; D000097629:Nociceptin; C063076:tyrosyl-arginyl-phenylalanyl-lysinamide