title: [Abdominal complaints and neurological symptoms as an early sign of lung cancer: a manifestation of the anti-Hu syndrome].
abstract: In two patients, women aged 73 and 46 years, gastrointestinal symptoms were initially not recognised as a paraneoplastic syndrome due to small-cell lung cancer. This led to redundant diagnostics as well as a delay in final diagnosis. The anti-Hu syndrome is characterised by the presence of anti-Hu antibodies and neurological symptoms. About a quarter of the patients with the anti-Hu syndrome will develop gastrointestinal motility disorders in the course of their illness. The primary tumour is usually a small-cell lung cancer. Whereas the presence of anti-Hu antibodies appears to be beneficial for the oncological prognosis, the neurological outcome is less favourable.
authors.affiliation: Afd. Interne Geneeskunde, onderafd. Medische Oncologie, Academisch Ziekenhuis, Postbus 30.001, 9700 RB Groningen.
authors.forename: A N M
authors.initials: AN
authors.lastname: Wymenga
authors.forename: D J
authors.initials: DJ
authors.lastname: Slebos
authors.forename: J
authors.initials: J
authors.lastname: van der Naalt
authors.forename: J W G
authors.initials: JW
authors.lastname: van Putten
authors.forename: F T M
authors.initials: FT
authors.lastname: Peters
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000276:immunology*; D003937:Diagnosis, Differential; D051959:ELAV Proteins; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis; D005769:Gastrointestinal Motility; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000276:immunology*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D009422:Nervous System Diseases / Q000175:diagnosis; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000276:immunology*; D011379:Prognosis; D016601:RNA-Binding Proteins / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D051959:ELAV Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins
vernacular_title: Buikklachten en neurologische symptomen als vroege manifestatie van longkanker: een uiting van het anti-Hu-syndroom.