title: [The prothrombotic state in early stages of chronic chagas' disease].
abstract: OBJECTIVE
  This study was designed to explore the presence of a prothrombotic state in the early stages of chronic Chagas' disease by evaluating serum markers of thrombosis and fibrinolysis.
  
  
  METHODS
  Forty-two patients with chronic Chagas' disease (12 men and 30 women, 32.5 6.7 years) were compared with 21 healthy volunteers (10 men and 11 women, 24.2 5.6 years). The markers of thrombotic activation used were fragment 1 + 2, ATM complex, PDF/pdf, D-dimer, and beta-thromboglobulin. Fibrinolysis was evaluated before and after venous occlusion, together with euglobulin lysis time, t-PA, and PAI-1 titers.
  
  
  RESULTS
  The markers of thrombotic state were significantly higher in patients with chronic Chagas' disease than in controls: F1 + 2 (p < 0.0001), ATM (p < 0.0001), PDF/pdf (p < 0.05), and D dimer (p < 0.05). There was no significant difference in beta-thromboglobulin (p = 0.06). Euglobulin lysis time, a global fibrinolytic marker, differed significantly (p < 0.0001) between patients with Chagas' disease and healthy volunteers. However, the more specific fibrinolytic markers t-PA and PAI-1 did not differ significantly between the two study groups.
  
  
  CONCLUSIONS
  Although there were no significant differences in fibrinolytic markers between patients with chronic Chagas' disease and healthy volunteers, the significant increase in thrombosis markers (F1 + 2, ATM complex, PDF/pdf, and D dimer) suggests the presence of a prothrombotic state in the early stages of chronic Chagas' disease.
authors.affiliation: Departamento de Hemostasia y Trombosis. Hospital Centro de Salud Zenón J. Santillán. Facultad de Medicina. Universidad Nacional de Tucumán. Argentina.
authors.forename: Ramón N
authors.initials: RN
authors.lastname: Herrera
authors.forename: Elba
authors.initials: E
authors.lastname: Díaz
authors.forename: Rossana
authors.initials: R
authors.lastname: Pérez
authors.forename: Sergio
authors.initials: S
authors.lastname: Chaín
authors.forename: Roque
authors.initials: R
authors.lastname: Sant-Yacumo
authors.forename: Eduardo
authors.initials: E
authors.lastname: Rodríguez
authors.forename: Jorge
authors.initials: J
authors.lastname: Bianchi
authors.forename: Alfredo
authors.initials: A
authors.lastname: Coviello
authors.forename: Julio
authors.initials: J
authors.lastname: Miotti
authors.forename: Isolina
authors.initials: I
authors.lastname: Flores
authors.forename: Fernando
authors.initials: F
authors.lastname: de la Serna
authors.forename: Juan
authors.initials: J
authors.lastname: Muntaner
authors.forename: Sofía
authors.initials: S
authors.lastname: Berman
authors.forename: Héctor
authors.initials: H
authors.lastname: Luciardi
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000502:physiology; D001779:Blood Coagulation Factors / Q000032:analysis*; D002598:Chagas Cardiomyopathy / Q000097:blood* / Q000150:complications; D002908:Chronic Disease; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D013927:Thrombosis / Q000097:blood* / Q000150:complications
chemical_list: D001779:Blood Coagulation Factors
vernacular_title: Estado protrombótico en estadios tempranos de la enfermedad de Chagas crónica.