title: Clinical and radiographic treatment evaluation of class III furcation defects using GTR with and without inorganic bone matrix.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of guided tissue regeneration (GTR) alone and in conjunction with a bovine inorganic bone matrix in furcation defects.
  
  
  METHODS
  Twenty class III furcation defects were treated in 18 non-smoker patients, 35-75 years old. Horizontal (CAL-H) and vertical clinical attachment levels (CAL-V), probing depths (PD), gingival margin levels (GML), horizontal (BDL-H) and vertical bone defect levels (BDL-V), and alveolar crest levels (ACL) were performed at baseline and at 6-month re-entry procedures. Subtraction radiography was used to assess gain or loss in optical density (OD) and area of bone fill (A) (baseline/6 months). After flap elevation, the sites were randomly assigned to receive GTR + Bio-Oss (test) or GTR treatment alone (control). Results were evaluated using anova.
  
  
  RESULTS
  Differences were statistically significant between baseline and re-entry for PD, ACL (p < 0.01) and GML (p < 0.05) for the control group, and for BDL-V (p < 0.01) for the test group. There was a gain in ACL for the test group and a reduction in ACL for the control group (p < 0.01). No differences were observed for OD and A.
  
  
  CONCLUSIONS
  The results of this study indicate that class III furcation defects are not predictably resolved utilizing GTR or GTR in combination with an inorganic bone matrix.
authors.affiliation: University of São Paulo, School of Dentistry of Ribeirão Preto, Brazil. dpalioto@forp.usp.br
authors.forename: Daniela Bazan
authors.initials: DB
authors.lastname: Palioto
authors.forename: Julio Cesar
authors.initials: JC
authors.lastname: Joly
authors.forename: Antonio Fernando Martorelli
authors.initials: AF
authors.lastname: de Lima
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Mota
authors.forename: Raul
authors.initials: R
authors.lastname: Caffesse
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000145:classification / Q000000981:diagnostic imaging / Q000601:surgery; D000539:Alveolar Process / Q000000981:diagnostic imaging; D000704:Analysis of Variance; D000818:Animals; D001857:Bone Matrix / Q000637:transplantation*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000145:classification / Q000000981:diagnostic imaging / Q000601:surgery*; D005889:Gingival Recession / Q000145:classification / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use; D017622:Periodontal Attachment Loss / Q000145:classification / Q000601:surgery; D010514:Periodontal Pocket / Q000145:classification / Q000601:surgery; D011859:Radiography; D013382:Subtraction Technique
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals