title: Gene expression profiles of human breast cancer progression.
abstract: Although distinct pathological stages of breast cancer have been described, the molecular differences among these stages are largely unknown. Here, through the combined use of laser capture microdissection and DNA microarrays, we have generated in situ gene expression profiles of the premalignant, preinvasive, and invasive stages of human breast cancer. Our data reveal extensive similarities at the transcriptome level among the distinct stages of progression and suggest that gene expression alterations conferring the potential for invasive growth are already present in the preinvasive stages. In contrast to tumor stage, different tumor grades are associated with distinct gene expression signatures. Furthermore, a subset of genes associated with high tumor grade is quantitatively correlated with the transition from preinvasive to invasive growth.
authors.affiliation: Applied Genomics Division, Arcturus, 2715 Loker Avenue West, Carlsbad, CA 92008, USA.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Ma
authors.forename: Ranelle
authors.initials: R
authors.lastname: Salunga
authors.forename: J Todd
authors.initials: JT
authors.lastname: Tuggle
authors.forename: Justin
authors.initials: J
authors.lastname: Gaudet
authors.forename: Edward
authors.initials: E
authors.lastname: Enright
authors.forename: Philip
authors.initials: P
authors.lastname: McQuary
authors.forename: Terry
authors.initials: T
authors.lastname: Payette
authors.forename: Maria
authors.initials: M
authors.lastname: Pistone
authors.forename: Kimberly
authors.initials: K
authors.lastname: Stecker
authors.forename: Brian M
authors.initials: BM
authors.lastname: Zhang
authors.forename: Yi-Xiong
authors.initials: YX
authors.lastname: Zhou
authors.forename: Heike
authors.initials: H
authors.lastname: Varnholt
authors.forename: Barbara
authors.initials: B
authors.lastname: Smith
authors.forename: Michelle
authors.initials: M
authors.lastname: Gadd
authors.forename: Erica
authors.initials: E
authors.lastname: Chatfield
authors.forename: Jessica
authors.initials: J
authors.lastname: Kessler
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Baer
authors.forename: Mark G
authors.initials: MG
authors.lastname: Erlander
authors.forename: Dennis C
authors.initials: DC
authors.lastname: Sgroi
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D018450:Disease Progression; D004798:Enzymes / Q000235:genetics; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017403:In Situ Hybridization; D009363:Neoplasm Proteins / Q000235:genetics; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction
chemical_list: D004798:Enzymes; D009363:Neoplasm Proteins