title: IgG class antibodies to heat shock-induced streptococcal antigens in psoriatic patients.
abstract: BACKGROUND
  Psoriasis is a chronic inflammatory skin disease. Probably autoimmune in nature, and associated with streptococcal throat infections as a triggering factor. Although many groups have associated the disease with other pathogens, Streptococcus pyogenes seems to be the most important microorganism related to this disease. Therefore, it is necessary to identify the streptococcal antigens involved in the process.
  
  
  METHODS
  In this work IgG class antibodies to soluble antigens obtained from Staphyloccus aureus, Candica albicans or S. pyogenes before and after heat shock induction, were analyzed by ELISA in 28 psoriatic patients and 30 healthy donors.
  
  
  RESULTS
  In all cases, the patients and the controls had IgG class antibodies to the four antigens. Nevertheless, the IgG levels to the heat shock-induced S. pyognes were statistically different between the patients and the controls (P < 0.001). There was no difference between the groups when the IgG antibodies to the other antigens, including the noninduced streptococcal extract, were analyzed. Additionally, anti-streptolysin O titers and throat cultures were carried out in all patients and controls. No differences between ASO titers were found but the patients were more frequently colonized by pyogenes.
  
  
  CONCLUSIONS
  Results obtained in this study suggest that heat shock-induced proteins from S. pyogenes are associated with psoriasis.
authors.affiliation: Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, IPN, México DF, México.
authors.forename: Rolando
authors.initials: R
authors.lastname: Pérez-Lorenzo
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Zambrano-Zaragoza
authors.forename: Karina
authors.initials: K
authors.lastname: Moo-Castillo
authors.forename: Dora L
authors.initials: DL
authors.lastname: Luna-Vázquez
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Ruiz-Guillermo
authors.forename: Ethel
authors.initials: E
authors.lastname: García-Latorre
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis*; D000942:Antigens, Bacterial / Q000276:immunology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010614:Pharynx / Q000382:microbiology; D011565:Psoriasis / Q000276:immunology / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D006360:Heat-Shock Proteins; D007074:Immunoglobulin G