title: Progress in determining the malignant potential of oral lesions.
abstract: The dilemma in managing patients with potentially malignant oral lesions and field change is of deciding which mucosal lesions or areas will progress to carcinoma. Although dysplasia may be predictive, this is not invariable, and there can be considerable inter- and intraexaminer variation in that diagnosis. Recent data on molecular and DNA changes in potentially malignant lesions suggest that it is now feasible to identify those lesions that are truly potentially malignant.
authors.affiliation: Eastman Dental Institute for Oral Health Care Sciences, World Health Organisation Collaborating Centre for Oral Health, Disability and Culture, UCL University of London, 256 Gray's Inn Road, London WC1X 8LD, UK.
authors.forename: C
authors.initials: C
authors.lastname: Scully
authors.forename: J
authors.initials: J
authors.lastname: Sudbø
authors.forename: P M
authors.initials: PM
authors.lastname: Speight
mesh_terms: D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003937:Diagnosis, Differential; D018450:Disease Progression; D004919:Erythroplasia / Q000473:pathology*; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D007971:Leukoplakia / Q000473:pathology*; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats; D009062:Mouth Neoplasms / Q000473:pathology*; D011237:Predictive Value of Tests; D016159:Tumor Suppressor Protein p53
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53