Autism and mental retardation: the genetic relationship and contribution.
Autism, a neurodevelopmental disorder first described in 1943, is reviewed. The signs and symptoms of the disorder are described together with the etiological factors. The evidence for a genetic etiology of autism and its association with other genetic disorders are discussed. Possible candidate genes for autism are described.
el-Hazmi
M A
MA
Department of Medical Biochemistry, WHO Collaborating Centre for Haemoglobinopathies, Thalassaemias and Enzymopathies, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia. mohsen@ksu.edu.sa
D001321:Autistic Disorder / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D008607:Intellectual Disability / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D008297:Male; D010375:Pedigree; D012307:Risk Factors; D018433:Twin Studies as Topic