title: Novel synthetic approach to the 8,10-dimethyl anti-syn-anti-perhydrophenanthrene skeleton.
abstract: [reaction: see text] An efficient and highly stereocontrolled approach to the 8,10-dimethyl anti-syn-anti-perhydrophenanthrene carbon skeleton starting with the Wieland-Miescher ketone is described. The approach centers on a Diels-Alder-angular methylation-deoxygenation sequence.
authors.affiliation: The Laboratory for Bioorganic Chemistry, The Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.
authors.forename: Don M
authors.initials: DM
authors.lastname: Coltart
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Danishefsky
mesh_terms: D007659:Ketones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D010084:Oxidation-Reduction; D010616:Phenanthrenes / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D010616:Phenanthrenes