title: Analysis of part of the chicken Rfp-Y region reveals two novel lectin genes, the first complete genomic sequence of a class I alpha-chain gene, a truncated class II beta-chain gene, and a large CR1 repeat.
abstract: The Rfp-Y region lies on the same microchromosome as the B-F/B-L region of the B complex, yet in contrast to the latter it is poorly characterised. To date it has been shown to contain at least two class I alpha-chain ( Y-F) genes, a class II B-chain gene and a C-type lectin-like gene. We describe the sequencing and analysis of some 20 kb of the Rfp-Y region, and identify several new genes. These include two novel C-type lectin-like genes ( Y-Lec1 and Y-Lec2) that differ strongly from the previously described C-type lectin-like gene found in the Rfp-Y region. We describe a complete genomic sequence of a class I alpha-chain ( Y-F) gene and its promoter from the Rfp-Y region. The predicted cDNA from this gene has high homology to the previously reported Y-F cDNAs. The promoter contains an altered enhancer A element. This portion of the Rfp-Y region also contains a truncated class II B-chain ( Y-LB) gene, as well as a large chicken repeat 1 (CR1) element.
authors.affiliation: Institute for Animal Health, Compton, Berkshire, RG20 7NN, UK.
authors.forename: Sally
authors.initials: S
authors.lastname: Rogers
authors.forename: Iain
authors.initials: I
authors.lastname: Shaw
authors.forename: Norman
authors.initials: N
authors.lastname: Ross
authors.forename: Venugopal
authors.initials: V
authors.lastname: Nair
authors.forename: Lisa
authors.initials: L
authors.lastname: Rothwell
authors.forename: Jim
authors.initials: J
authors.lastname: Kaufman
authors.forename: Pete
authors.initials: P
authors.lastname: Kaiser
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002645:Chickens / Q000235:genetics* / Q000276:immunology; D004742:Enhancer Elements, Genetic; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D037102:Lectins / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D037102:Lectins