title: Morphometric analysis of dendritic tree of cerebellar Purkinje-cells.
abstract: Basic neural processes of sensorimotor adaptation can be observed by cellular-level studies on cerebellar cortex, both by electrophysiological and morphological means. In earlier studies we demonstrated double (sometimes triple or quadruple) rhythmic prespike activity patterns in dendritic microelectrode records taken from cerebellar Pc. By their active and passive interactions, the actual input pattern will turn into an arrhythmic output spiking, realizing a nonlinear and phase-sensitive integration. This curious complex spike-generating process can give rise to novel cerebellar functional models. The acting membrane dynamics rely not just upon the ionic current machinery but also upon the specific micromorphology of the dendritic tree, especially that of the branching areas. Although, statistical analyses on Pc dendrites generally followed the graph-theory, elaborated abstract parameters for complexity and hierarchy, and denied realistic geometry. Thus a novel specific morphometric study should be carried out, first applied to the main branching sites.
authors.affiliation: Laboratory of Sensorimotor Adaptation, Semmelwiess University Medical School, Budapest, Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Simon
authors.forename: D
authors.initials: D
authors.lastname: Káldy
authors.forename: G
authors.initials: G
authors.lastname: Heja
authors.forename: T
authors.initials: T
authors.lastname: Kiss
authors.forename: T
authors.initials: T
authors.lastname: Bakó
mesh_terms: D000818:Animals; D002415:Cats; D003712:Dendrites / Q000502:physiology*; D007091:Image Processing, Computer-Assisted; D011689:Purkinje Cells / Q000145:classification* / Q000166:cytology; D012984:Software