Background gradient suppression in pulsed gradient stimulated echo measurements.
Pulsed gradient spin echo (PGSE) experiments can be used to measure the probability distribution of molecular displacements. In homogeneous samples this reports on the molecular diffusion coefficient, and in heterogeneous samples, such as porous media and biological tissue, such measurements provide information about the sample's morphology. In heterogeneous samples however background gradients are also present and prevent an accurate measurement of molecular displacements. The interference of time independent background gradients with the applied magnetic field gradients can be removed through the use of bipolar gradient pulses. However, when the background gradients are spatially non-uniform molecular diffusion introduces a temporal modulation of the background gradients. This defeats simple bipolar gradient suppression of background gradients in diffusion related measurements. Here we introduce a new method that requires the background gradients to be constant over coding intervals only. Since the coding intervals are typically at least an order of magnitude shorter than the storage time, this new method succeeds in suppressing cross-terms for a much wider range of heterogeneous samples.
Sun
Phillip Zhe
PZ
Division of Health Sciences and Technology, Harvard University-MIT, 77 Massachusetts Avenue, E25-519, Cambridge, MA 02139, USA.
Seland
John Georg
JG
Cory
David
D
D004058:Diffusion; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*