title: Appropriateness of a pneumococcal conjugate vaccine in Brazil: potential impact of age and clinical diagnosis, with emphasis on meningitis.
abstract: The distribution of pneumococcal serotypes in Brazil was analyzed by age group and clinical diagnosis, using data obtained during 20 years of national surveillance. Serotypes 1 and 5 remained among the main serotypes in all age groups, increasing in frequency with age. Serotype 14 was prevalent among children, whereas serotypes 3 and 4 were most prevalent among the adult population. The potential impact of the 7- and 9-valent conjugate vaccines on children up to age 5 years with severe pneumococcal diseases was 58.2% and 73%, respectively; the highest coverage of the 7-valent vaccine for pneumonia was achieved for children aged 7 months to 2 years (70%), whereas, for meningitis, it was observed for children aged 7 months to 5 years (58.6%). The use of conjugate vaccine may be of potential benefit by reducing the childhood sequelae and mortality of pneumococcal infection in Brazil.
authors.affiliation: Secao de Bacteriologia, Adolfo Lutz Institute, Secretary of Health for the State of São Paulo, São Paulo, Brazil. brandi@ial.sp.gov.br
authors.forename: Maria-Cristina C
authors.initials: MC
authors.lastname: Brandileone
authors.forename: Ana-Lucia S Sgambatti
authors.initials: AL
authors.lastname: de Andrade
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Di Fabio
authors.forename: Maria-Luiza L S
authors.initials: ML
authors.lastname: Guerra
authors.forename: Robert
authors.initials: R
authors.lastname: Austrian
mesh_terms: D000375:Aging / Q000502:physiology*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008586:Meningitis, Pneumococcal / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000276:immunology*; D015995:Prevalence; D016036:Seroepidemiologic Studies; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000276:immunology*; D018074:Vaccines, Conjugate / Q000276:immunology*
chemical_list: D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate