Treatment of vaginal outflow tract obstruction in graft-versus-host reaction.
We describe five patients with vaginal stenosis that was due to chronic graft-versus-host reaction after bone marrow transplantation. All patients underwent surgical procedures followed by local corticosteroids administration. Vaginal function was restored in all cases. This satisfactory result persists in the long term.
Louis-Sylvestre
Christine
C
Service de Gynécologie, Centre Hospitalier Intercommunal, Creteil, France.
Haddad
Bassam
B
Paniel
Bernard-Jean
BJ
D000282:Administration, Intravaginal; D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D003251:Constriction, Pathologic / Q000209:etiology / Q000628:therapy; D004106:Dilatation; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications*; D013509:Gynecologic Surgical Procedures; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008875:Middle Aged; D012189:Retrospective Studies; D015607:Stents; D016896:Treatment Outcome; D014622:Vaginal Creams, Foams, and Jellies; D014623:Vaginal Diseases / Q000209:etiology* / Q000628:therapy*
D000893:Anti-Inflammatory Agents; D014622:Vaginal Creams, Foams, and Jellies; C021650:hydrocortisone acetate; D006854:Hydrocortisone