Modeling the relation between cardiac pump function and myofiber mechanics.
Complexity of the geometry and structure of the heart hampers easy modeling of cardiac mechanics. The modeling can however be simplified considerably when using the hypothesis that in the normal heart myofiber structure and geometry adapt, until load is evenly distributed. A simple and realistic relationship is found between the hemodynamic variables cavity pressure and volume, and myofiber load parameters stress and strain. The most important geometric parameter in the latter relation is the ratio of cavity volume to wall volume, while actual geometry appears practically irrelevant. Applying the found relationship, a realistic maximum is set to left ventricular pressure after chronic pressure load. Pressures exceeding this level are likely to cause decompensation and heart failure. Furthermore, model is presented to simulate left and right ventricular pump function with left-right interaction.
Arts
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Faculty of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. t.arts@bf.unimaas.nl
Bovendeerd
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Delhaas
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Prinzen
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D000222:Adaptation, Physiological / Q000502:physiology; D001794:Blood Pressure; D003198:Computer Simulation; D006321:Heart / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology*; D009210:Myofibrils / Q000502:physiology*; D013318:Stroke Volume; D016276:Ventricular Function; D016277:Ventricular Function, Left / Q000502:physiology*