Dynactin: coordinating motors with opposite inclinations.
In eukaryotic cells, many organelles are transported bidirectionally along microtubules by kinesin and dynein. These opposite-polarity motors appear to be coordinated to avoid interfering with each other's function. New work has provided the first molecular insight into how such coordination might occur.
Gross
Steven P
SP
Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA. sgross@uci.edu
D000818:Animals; D000072159:Dynactin Complex; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism* / Q000502:physiology; D015388:Organelles / Q000378:metabolism / Q000502:physiology*
D000072159:Dynactin Complex; D008869:Microtubule-Associated Proteins; D020409:Molecular Motor Proteins