title: A hybrid zinc-calcium-silicate polyalkenoate bone cement.
abstract: A novel bone cement composed of sintered zinc-calcium-silicate phosphate and hybrid polyalkenoates has been developed. Synthesis and formulation of glass fillers, monomers and polymers as well as formulation of the cement were described. The effects of sintering, polymer content, glass powder/polymer liquid (P/L) ratio and comonomer on compressive strength (CS) and curing time (CT) were investigated. The effects of P/L ratio and comonomers on shrinkage as well as exotherm were also studied. Results show that the experimental cement was 61% higher in CS, 10% lower in diametral tensile strength, 35% lower in flexural strength, 62% less in exotherm, and 68% less in shrinkage, compared to conventional polymethylmethacrylate cement. With increasing polymer content and P/L ratio in the cement formulation CS of the cement increased but CT decreased. Curing time, shrinkage and exotherm of the cement decreased with increasing P/L ratio. It appears that this novel cement may be a potential candidate for orthopedic restoration if its biological performance is good and formulation is optimized.
authors.affiliation: Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL 35294, USA. dxie@eng.uab.edu
authors.forename: Dong
authors.initials: D
authors.lastname: Xie
authors.forename: Dingsong
authors.initials: D
authors.lastname: Feng
authors.forename: Il-Doo
authors.initials: ID
authors.lastname: Chung
authors.forename: Alan W
authors.initials: AW
authors.lastname: Eberhardt
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D001843:Bone Cements / Q000138:chemical synthesis / Q000737:chemistry*; D017610:Calcium Compounds / Q000737:chemistry; D002484:Cementation / Q000295:instrumentation / Q000379:methods*; D019245:Compressive Strength; D004548:Elasticity; D005899:Glass Ionomer Cements / Q000138:chemical synthesis / Q000737:chemistry* / Q000145:classification; D006358:Hot Temperature; D008422:Materials Testing; D012823:Silicate Cement / Q000138:chemical synthesis / Q000737:chemistry*; D017640:Silicates / Q000138:chemical synthesis / Q000737:chemistry; D013499:Surface Properties; D013718:Tensile Strength; D017967:Zinc Compounds / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D017610:Calcium Compounds; D005899:Glass Ionomer Cements; D017640:Silicates; D017967:Zinc Compounds; D012823:Silicate Cement; C031293:calcium silicate; C029500:zinc silicate