DNA fuel for free-running nanomachines.
We describe kinetic control of DNA hybridization: loop complexes are used to inhibit the hybridization of complementary oligonucleotides; rationally designed DNA catalysts are shown to be effective in promoting their hybridization. This is the basis of a strategy for using DNA as a fuel to drive free-running artificial molecular machines.
Turberfield
A J
AJ
University of Oxford, Department of Physics, Clarendon Laboratory, Parks Road, Oxford OX1 3PU, United Kingdom. A.Turberfield@physics.ox.ac.uk
Mitchell
J C
JC
Yurke
B
B
Mills
A P
AP
Blakey
M I
MI
Simmel
F C
FC
D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D036103:Nanotechnology / Q000379:methods*; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry
D009841:Oligonucleotides; D004247:DNA