Exercise training and antioxidants: relief from oxidative stress and insulin resistance.
There is evidence for an association between oxidative stress and insulin resistance, possibly due to downregulation of insulin signaling. This review will address the hypothesis that exercise training and the antioxidant R-(+)-lipoic acid interact at the level of insulin signaling to enhance glucose transport in insulin-resistant skeletal muscle.
Henriksen
Erik J
EJ
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson 85721-0093, USA. ejhenrik@u.arizona.edu
Saengsirisuwan
Vitoon
V
D003920:Diabetes Mellitus / Q000503:physiopathology; D015444:Exercise / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D023421:Models, Animal; D015394:Molecular Structure; D018482:Muscle, Skeletal / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D010805:Physical Conditioning, Animal; D008063:Thioctic Acid / Q000737:chemistry / Q000502:physiology*
D008063:Thioctic Acid; D005947:Glucose