title: The detection of non-adherence by self-administered questionnaires can be optimized by protease inhibitor plasma concentration determination.
abstract: Self-reported adherence and plasma protease inhibitor concentration (PPIC) were assessed in 642 HIV-infected patients at month 4 of a single protease inhibitor-containing regimen. PPIC was below the limit of quantification (LOQ) in 32% of non-adherent patients and in 8% of adherent patients. The relationship between non-adherence and a detectable HIV viral load was enhanced when adherent patients with PPIC below LOQ were considered to be non-adherent. PPIC combined with self-report may more reliably detect non-adherence.
authors.affiliation: INSERM U379, Marseille, France.
authors.forename: Ségolène
authors.initials: S
authors.lastname: Duran
authors.forename: Gilles
authors.initials: G
authors.lastname: Peytavin
authors.forename: Patrizia
authors.initials: P
authors.lastname: Carrieri
authors.forename: François
authors.initials: F
authors.lastname: Raffi
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Ecobichon
authors.forename: Edwige
authors.initials: E
authors.lastname: Pereira
authors.forename: Gilles Patrice
authors.initials: GP
authors.lastname: Cassuto
authors.forename: Bruno
authors.initials: B
authors.lastname: Spire
authors.forename: Catherine
authors.initials: C
authors.lastname: Leport
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D010349:Patient Compliance; D012650:Self Disclosure; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D019562:Viral Load
chemical_list: D017320:HIV Protease Inhibitors