title: Determination of ethylene oxide by solid-phase microextraction device with on-fiber derivatization.
abstract: The solid-phase microextraction (SPME) device was used as a time-weighted average (TWA) sampler for ethylene oxide. Carboxen/polydimethylsiloxane (CAR/PDMS) fiber was used and hydrogen bromide (HBr) was loaded onto the fiber. The SPME fiber assembly was then inserted into PTFE tubing to improve the wearer's acceptance as a diffusive sampler. Known concentrations of ethylene oxide around the threshold limit values (TLVs)/time-weighted average and specific relative humidities (RHs) were generated by syringe pumps in a dynamic generation system. Ethylene oxide in gas bags were also generated. An exposure chamber was designed to allow measurement of face velocities, temperatures, exposing vapor concentrations, and RHs. Gas chromatography-mass spectrometry (GC-MS) was used for sample analysis. The appropriate adsorption time for SPME coating HBr was found to be 30 s and the desorption time for 2-bromothanol formed after sampling was determined to be 5 min. The experimental sampling constant of the sampler was found to be (2.96 +/- 0.09) x 10(-2) cm3/min, while face velocity (0-0.25 m/s) as well as RHs (10-80%) were not expected to have effects on the sampler.
authors.affiliation: Department of Occupational Safety and Health and Institute of Environmental Medicine, China Medical College 91, Hsueh-Shih Road, Taichung, Taiwan. shihwei@mail.cmc.edu.tw
authors.forename: Shih-Wei
authors.initials: SW
authors.lastname: Tsai
authors.forename: Kai-Kuang
authors.initials: KK
authors.lastname: Wu
mesh_terms: D000395:Air Pollutants, Occupational / Q000032:analysis* / Q000592:standards; D000431:Ethanol / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D005027:Ethylene Oxide / Q000032:analysis* / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry / Q000295:instrumentation / Q000379:methods; D006813:Humidity; D018054:Hydrobromic Acid; D008832:Microchemistry / Q000295:instrumentation; D015203:Reproducibility of Results; D013696:Temperature; D020711:Threshold Limit Values
chemical_list: D000395:Air Pollutants, Occupational; D018054:Hydrobromic Acid; D000431:Ethanol; D005027:Ethylene Oxide; C025475:ethylene bromohydrin