title: Neurobrucellosis in an endemic area of brucellosis.
abstract: Central nervous system involvement occurs less than 5% of patients with brucellosis. A prospective analysis of 73 patients with brucellosis identified 13 (17.8%) neurobrucellosis cases from February 2001 to May 2002. 10 patients had chronic meningitis and 3 acute meningitis. Two patients had only psychiatric disorders. Cranial nerve involvement was observed in 3 patients (6th, 7th and 8th nerves). Three patients had positive blood cultures and 3 others had positive cerebrospinal fluid (CSF) cultures. 12 patients had positive agglutination titres in CSF. All patients received antibiotic therapy with ceftriaxone, rifampicin and doxycycline initially, and after 1 month they were continued with rifampicin and doxycycline up to 4 months. All patients were completely cured. Hearing loss developed in 1 patient as a sequela.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Hürrem
authors.initials: H
authors.lastname: Bodur
authors.forename: Ayse
authors.initials: A
authors.lastname: Erbay
authors.forename: Esragül
authors.initials: E
authors.lastname: Akinci
authors.forename: Aylin
authors.initials: A
authors.lastname: Colpan
authors.forename: Mustafa A
authors.initials: MA
authors.lastname: Cevik
authors.forename: Neriman
authors.initials: N
authors.lastname: Balaban
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000900:Anti-Bacterial Agents; D001774:Blood Chemical Analysis; D002006:Brucellosis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D015331:Cohort Studies; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D019353:Endemic Diseases / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D008875:Middle Aged; D009460:Neurologic Examination; D011336:Probability; D011379:Prognosis; D012307:Risk Factors; D012494:Sampling Studies; D012720:Severity of Illness Index; D017678:Sex Distribution; D013129:Spinal Puncture; D014421:Turkey / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents