A randomised double-blind evaluation of adenosine as adjunct to sufentanil in spinal labour analgesia.
BACKGROUND
Intrathecal injection of sufentanil offers labour pain relief of short duration. This double-blind randomised study evaluates if the combination of adenosine to sufentanil could give relevant prolongation (40%) of the duration of sufentanil spinal analgesia.


METHODS
Twenty-five healthy parturients requesting labour analgesia were included. Patients received 10 micro g of sufentanil + 500 micro g of adenosine or 10 micro g of sufentanil intrathecally. Pain intensity and duration of pain relief were assessed.


RESULTS
Pain relief was equal between groups. Duration of analgesia was not increased by adenosine + sufentanil, 99 +/- 54 min, vs. sufentanil, 89 +/- 56 min.


CONCLUSIONS
Adding 500 micro g of adenosine to 10 micro g of sufentanil could not provide any prolongation of labour pain relief.
Rane
K
K
Department of Anaesthesia and Intensive Care, Danderyd Hospital, Danderyd, Sweden. kerstin.rane@ane.ds.sll.se
Sollevi
A
A
Segerdahl
M
M
D000241:Adenosine; D000759:Adjuvants, Anesthesia; D000328:Adult; D016362:Analgesia, Obstetrical; D000701:Analgesics, Opioid / Q000008:administration & dosage; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D011247:Pregnancy; D017409:Sufentanil / Q000008:administration & dosage
D000759:Adjuvants, Anesthesia; D000701:Analgesics, Opioid; D017409:Sufentanil; D000241:Adenosine