title: Genetic analysis for diabetes in a new rat model of nonobese type 2 diabetes, Spontaneously Diabetic Torii rat.
abstract: The Spontaneously Diabetic Torii (SDT) rat has recently been established as a new rat model of nonobese type 2 diabetes. In this study, we characterized diabetic features in SDT rats, and performed quantitative trait locus (QTL) analysis for glucose intolerance using 319 male (BNxSDT)xSDT backcrosses. Male SDT rats exhibited glucose intolerance at 20 weeks, and spontaneously developed diabetes with the incidence of 100% at 38 weeks, and glucose intolerance is well associated with the development of diabetes. The QTL analysis identified three highly significant QTLs (Gisdt1, Gisdt2, and Gisdt3) for glucose intolerance on rat chromosomes 1, 2, and X, respectively. The SDT allele for these QTLs significantly exacerbated glucose intolerance. Furthermore, synergistic interactions among these QTLs were detected. These findings indicate that diabetic features in SDT rats are inherited as polygenic traits and that SDT rats would provide insights into genetics of human type 2 diabetes.
authors.affiliation: Laboratory of Veterinary Anatomy, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, 020-8550, Iwate, Japan. t.masuyama@tba.t-com.ne.jp <t.masuyama@tba.t-com.ne.jp>
authors.forename: Taku
authors.initials: T
authors.lastname: Masuyama
authors.forename: Masanori
authors.initials: M
authors.lastname: Fuse
authors.forename: Norihide
authors.initials: N
authors.lastname: Yokoi
authors.forename: Masami
authors.initials: M
authors.lastname: Shinohara
authors.forename: Hirotada
authors.initials: H
authors.lastname: Tsujii
authors.forename: Masao
authors.initials: M
authors.lastname: Kanazawa
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Kanazawa
authors.forename: Kajuro
authors.initials: K
authors.lastname: Komeda
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Taniguchi
mesh_terms: D017668:Age of Onset; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics* / Q000473:pathology; D004195:Disease Models, Animal; D005838:Genotype; D018149:Glucose Intolerance / Q000097:blood / Q000235:genetics; D008297:Male; D010641:Phenotype; D040641:Quantitative Trait Loci; D051381:Rats; D011919:Rats, Inbred Strains; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose