title: [Persistence of pathogenic bacteria: theory and practice].
abstract: Persistence of pathogenic bacteria is viewed as a model of the parasite--host system. The variable signs of the pathogen and the host body, responsible for the mutual adaptation of the symbionts, are evaluated. The tactical ways of bacteria, enabling them to defend (isolate) their peptidoglycan from immune recognition by the host and thus ensuring the phenomenon of persistence, are presented. An attempt to assess the relationship between the persistence of bacteria ans their pathogenicity has been made. As noted in this study, the survival of bacteria inside host cells is determined by the expression of genes responsible for the adaptation of microorganisms to novel environmental conditions, ans the life of an infective agent adapted to the host is regarded as a series of steps of gene activation in response to the discrete complex of environmental conditions. Approaches to the solution of applied tasks in medicine, biology and ecology with the use of microbial persistence as the model of the parasite--host system is discussed.
authors.affiliation: Research Institute of Cellular and Intracellular Symbiosis, Orenburg, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Bukharin
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics / Q000276:immunology; D000818:Animals; D001419:Bacteria / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology*; D017753:Ecosystem; D004783:Environmental Microbiology; D006790:Host-Parasite Interactions / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D010457:Peptidoglycan / Q000378:metabolism*; D013559:Symbiosis / Q000235:genetics / Q000276:immunology / Q000502:physiology
chemical_list: D010457:Peptidoglycan
vernacular_title: Persistentsiia patogennykh bakteriĭ: teoriia i praktika.