title: Acceleration and augmentation strategies for treating bipolar depression.
abstract: Despite the prevalence and morbidity of bipolar depression, few randomized treatment trials have been conducted to assess clinical efficacy. Even fewer studies have assessed approaches that optimize treatment response for bipolar depression. This review will define three types of common combination strategies--adjunctive, acceleration and augmentation--and discuss the limited literature of controlled studies reported on acceleration and augmentation approaches.
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095, USA.
authors.forename: Lori L
authors.initials: LL
authors.lastname: Altshuler
authors.forename: Mark A
authors.initials: MA
authors.lastname: Frye
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Gitlin
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D018692:Antimanic Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D010869:Pindolol / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D012892:Sleep Deprivation; D013963:Thyroid Hormones / Q000502:physiology
chemical_list: D000319:Adrenergic beta-Antagonists; D000928:Antidepressive Agents; D018692:Antimanic Agents; D014150:Antipsychotic Agents; D013963:Thyroid Hormones; D008094:Lithium; D010869:Pindolol