title: Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors.
abstract: Novel nanomaterials for bioassay applications represent a rapidly progressing field of nanotechnology and nanobiotechnology. Here, we present an exploration of single-walled carbon nanotubes as a platform for investigating surface-protein and protein-protein binding and developing highly specific electronic biomolecule detectors. Nonspecific binding on nanotubes, a phenomenon found with a wide range of proteins, is overcome by immobilization of polyethylene oxide chains. A general approach is then advanced to enable the selective recognition and binding of target proteins by conjugation of their specific receptors to polyethylene oxide-functionalized nanotubes. This scheme, combined with the sensitivity of nanotube electronic devices, enables highly specific electronic sensors for detecting clinically important biomolecules such as antibodies associated with human autoimmune diseases.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Chen
authors.forename: Sarunya
authors.initials: S
authors.lastname: Bangsaruntip
authors.forename: Katerina A
authors.initials: KA
authors.lastname: Drouvalakis
authors.forename: Nadine Wong Shi
authors.initials: NW
authors.lastname: Kam
authors.forename: Moonsub
authors.initials: M
authors.lastname: Shim
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
authors.forename: Woong
authors.initials: W
authors.lastname: Kim
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Utz
authors.forename: Hongjie
authors.initials: H
authors.lastname: Dai
mesh_terms: D015374:Biosensing Techniques; D018625:Microscopy, Atomic Force; D036103:Nanotechnology; D012666:Semiconductors