YM-266183 and YM-266184, novel thiopeptide antibiotics produced by Bacillus cereus isolated from a marine sponge. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological properties.
Novel antibiotics, YM-266183 (1) and YM-266184 (2), were found in the culture broth of Bacillus cereus QN03323 which was isolated from the marine sponge Halichondria japonica. The structures of both antibiotics were determined by several spectroscopic experiments as new thiopeptide compounds. They exhibited potent antibacterial activities against staphylococci and enterococci including multiple drug resistant strains, whereas they were inactive against Gram-negative bacteria.
Nagai
Koji
K
Microbiology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 1-1-8 Azusawa, Itabashi-ku, Tokyo 174-8511, Japan. nagai@ymanouchi.co.jp
Kamigiri
Kazuma
K
Arao
Nakako
N
Suzumura
Ken-ichi
K
Kawano
Yasuhiro
Y
Yamaoka
Masakazu
M
Zhang
Huiping
H
Watanabe
Masato
M
Suzuki
Kenichi
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001409:Bacillus cereus / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D016983:Enterococcus / Q000187:drug effects; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D008970:Molecular Weight; D010455:Peptides / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011161:Porifera / Q000382:microbiology*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013210:Staphylococcus / Q000187:drug effects; D013844:Thiazoles / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010455:Peptides; D010456:Peptides, Cyclic; D013844:Thiazoles; C474182:YM 266183; C474183:YM 266184