Healing of intrabony defects following treatment with a bovine-derived xenograft and collagen membrane. A controlled clinical study.
OBJECTIVE
: The purpose of the present study was to compare clinically the treatment of deep intrabony defects with a combination of a bovine-derived xenograft (BDX) and a bioresorbable collagen membrane to access flap surgery.


METHODS
: Twenty-eight patients suffering from chronic periodontitis, and each of whom displayed one intrabony defect, were randomly treated with BDX + collagen membrane (test) or with access flap surgery (control). Soft tissue measurements were made at baseline and at 1 year following therapy.


RESULTS
: No differences in any of the investigated parameters were observed at baseline between the two groups. Healing was uneventful in all patients. At 1 year after therapy, the test group showed a reduction in mean probing depth (PD) from 9.2+/-1.3 to 3.9+/-0.7 mm (p<0.001) and a change in mean clinical attachment level (CAL) from 10.2+/-1.5 to 6.2+/-0.5 mm (p<0.0001). In the control group, the mean PD was reduced from 9.0+/-1.2 to 5.2+/-1.8 mm (p<0.001) and the mean CAL changed from 10.5+/-1.5 to 8.4+/-2.1 mm (p<0.01). The test treatment resulted in statistically higher PD reductions (p<or=0.05) and CAL gains (p<0.001) than the control one. In the test group all sites (100%) gained at least 3 mm of CAL. In the control group no CAL gain occurred in four sites (29%), whereas at six sites (43%) the CAL gain was 2 mm. A CAL gain of 3 mm or more was measured in four defects (29%).


CONCLUSIONS
: Within the limits of the present study, it can be concluded that: (i) at 1 year after surgery both therapies resulted in significant PD reductions and CAL gains, and (ii) treatment with BDX+collagen membrane resulted in significantly higher CAL gains than treatment with access flap surgery.
Sculean
Anton
A
Department of Conservative Dentistry and Periodontology, Johannes-Gutenberg University, Mainz, Germany. anton.sculean@gmx.de
Berakdar
Mohammad
M
Chiantella
Giovanni C
GC
Donos
Nikolaos
N
Arweiler
Nicole B
NB
Brecx
Michel
M
D020341:Absorbable Implants; D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery*; D000818:Animals; D001857:Bone Matrix / Q000637:transplantation*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D002908:Chronic Disease; D003094:Collagen; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008567:Membranes, Artificial; D008903:Minerals / Q000627:therapeutic use*; D017622:Periodontal Attachment Loss / Q000473:pathology / Q000601:surgery; D010514:Periodontal Pocket / Q000473:pathology / Q000601:surgery; D010518:Periodontitis / Q000473:pathology / Q000601:surgery*; D013524:Surgical Flaps; D014183:Transplantation, Heterologous; D014945:Wound Healing
C077540:Bio-Oss; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen