Synthesis of novel acetylene-containing amino acids.
Novel synthetic procedures for the modification of non-proteinogenic acetylene-containing amino acids have been developed. The functionalization either proceeds via zinc/copper-mediated introduction of alkyl substituents, or via tungsten-catalyzed ring-closing alkyne metathesis reactions.
IJsselstijn
M
M
Department of Organic Chemistry, University of Nijmegen, Toernooiveld 1, NL 6525 ED Nijmegen, The Netherlands.
Kaiser
J
J
van Delft
F L
FL
Schoemaker
H E
HE
Rutjes
F P J T
FP
D000114:Acetylene / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D008956:Models, Chemical; D015032:Zinc / Q000737:chemistry
D000596:Amino Acids; D003300:Copper; D015032:Zinc; D000114:Acetylene