title: Early onset parkinsonism.
abstract: Early-onset parkinsonism refers to those patients with onset of a parkinsonian syndrome before age 40. These cases can be further subdivided into Young-onset (between ages 40 and 21) and Juvenile-onset (below age 21). In this review we will focus on the peculiar clinical features that distinguish these cases from classic late-onset parkinsonism, their characteristic response to medication, and their heterogeneous pathogenesis, including recent findings in the field of genetics that would suggest that a significant number of these patients are the result of genetic mutations.
authors.affiliation: Sección Enfermedades Extrapiramidales, Centro Neurológico-Hospital Francés & Laboratory of Experimental Parkinsonism, Instituto de Investigaciones Farmacológicas, ININFA-CONICET, Buenos Aires, Argentina. gersh@movi.com.ar
authors.forename: Oscar S
authors.initials: OS
authors.lastname: Gershanik
mesh_terms: D017668:Age of Onset; D006801:Humans; D010300:Parkinson Disease / Q000453:epidemiology*