hOGG1 Ser326Cys polymorphism modifies the significance of the environmental risk factor for colon cancer.
OBJECTIVE
To determine the association of hOGG1 (8-oxoguanine glycosylase I, OGG1) polymorphism of Ser326Cys substitution with colon cancer risk and possible interaction with known environmental risk factors.


METHODS
A case-control study with 125 colon cancer cases and 247 controls was conducted.


RESULTS
There was no major difference in Ser326Cys genotype distribution between cases and controls. The meat intake tended to increase the odds ratio for colon cancer with an OR of 1.72 (95 % confidence interval; CI=1.12-2.76). Such tendency was more prominent in Cys/Cys carriers (OR=4.31, 95 % CI=1.64-11.48), but meat intake was not a significant risk factor for colon cancer in Ser/Ser or Ser/Cys carriers. The OR for colon cancer was elevated with marginal significance in smokers who were Cys/Cys carriers (OR=2.75, 95 % CI=1.07-7.53) but not in Ser/Ser or Ser/Cys carriers.


CONCLUSIONS
These results suggest that the hOGG1 Ser326Cys polymorphism is probably not a major contributor to individual colon cancer susceptibility overall, but the Cys/Cys genotype may alter the impact of some environmental factors on colon cancer development.
Kim
Jae-Il
JI
Department of Surgery, Ilsan Paik Hospital, Inje University College of Medicine, 2240, Daehwa-dong, Ilsan-gu, Koyang shi, Kyunggi-do 412-270, Korea.
Park
Young-Jin
YJ
Kim
Ki-Hong
KH
Kim
Ji-Il
JI
Song
Byung-Joo
BJ
Lee
Meung-Soo
MS
Kim
Chul-Num
CN
Chang
Seok-Hyo
SH
D001483:Base Sequence; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000201:enzymology* / Q000209:etiology / Q000235:genetics*; D004247:DNA / Q000235:genetics; D043382:DNA-Formamidopyrimidine Glycosylase; D004032:Diet; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008460:Meat; D008875:Middle Aged; D009699:N-Glycosyl Hydrolases / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
D004247:DNA; D009699:N-Glycosyl Hydrolases; D043382:DNA-Formamidopyrimidine Glycosylase