HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish.
Polymorphism of the human leukocyte antigen has been implicated in a number of autoimmune disorders including ageing. In the course of the present study, no association of the human leukocyte antigen (HLA)-A1, B8, DR3 haplotype with a male Irish aged population, as previously reported, was observed. Two polymorphic nucleotides in the TNF cluster (G-308A TNF-alpha and G+252A TNF-beta), associated with increased TNF-alpha production, were shown to be in tight linkage disequilibrium with the class I and II HLA loci, generating HLA haplotypes with extended linkage disequilibrium. However, no age-related allele or genotype frequencies were observed for either polymorphic nucleotide.
Ross
Owen A
OA
Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, BT9 7TS, Northern Ireland, Belfast, UK. owenaross@hotmail.com
Curran
Martin D
MD
Rea
I Maeve
IM
Hyland
Paul
P
Duggan
Orla
O
Barnett
Christopher R
CR
Annett
Kathryn
K
Patterson
Chris
C
Barnett
Yvonne A
YA
Middleton
Derek
D
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006650:Histocompatibility Testing; D006801:Humans; D015810:Linkage Disequilibrium; D008136:Longevity / Q000235:genetics* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009660:Northern Ireland; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha