Early behavioral development in the spontaneously hypertensive rat: a comparison with the Wistar-Kyoto and Sprague-Dawley strains.
The spontaneously hypertensive rat (SHR) is often used as a model for childhood attention-deficit/hyperactivity disorder (ADHD). To investigate behavioral maturation in SHR, body weight, age at eye opening, and performance in several behavioral tasks in male and female SHR, Wistar-Kyoto (WKY), and Sprague-Dawley rats were compared. SHRs were slower in performing the righting reflex on PND 4 and negative geotaxis compared with WKY and Sprague-Dawley. Both SHR and WKY were delayed relative to Sprague-Dawley in eye opening and beam walking. Rotarod performance was comparable in the 3 strains. Males were faster to right themselves than females, but there were no other significant sex differences nor Sex X Strain interactions. Delayed development in SHR may be related to a maturational delay observed in children with ADHD. Research assessing early behaviors in SHR, WKY, and other strains will help determine the most appropriate model for childhood ADHD and may help predict later behavioral dysfunction.
Ferguson
Sherry A
SA
Division of Neurotoxicology, Jefferson, National Center for Toxicological Research, U.S. Food and Drug Administration, Arkansas 72079, USA. sferguson@nctr.fda.gov
Gray
Erika P
EP
Cada
Amy M
AM
D000367:Age Factors; D000818:Animals; D001835:Body Weight; D005106:Exploratory Behavior / Q000502:physiology; D005123:Eye; D005260:Female; D005552:Forelimb / Q000502:physiology; D005597:Fractures, Open; D008297:Male; D011247:Pregnancy; D011597:Psychomotor Performance / Q000502:physiology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology; D012018:Reflex; D013045:Species Specificity; D016138:Walking / Q000502:physiology