[Effect of melatonin on neurogenic vasoreactivity: formation and modulation of the vessel response].
The effect of melatonin (0.1 microM) on the contractile response to electrical field stimulation (EFS) of the juvenile rat tail artery segment was studied. The spontaneous decrease in reactivity of the segment observed in the course of our experiments was accompanied with a melatonin-evoked increase in the reactivity which was proportional to this decrease and was not connected with a sensitization of the segment to the substance. Perfusion of the segment with an acidic solution leads to a more pronounced inhibition of the response as well as to a greater melatonin-evoked protentiation of the response. Noradrenaline-evoked response was not augmented by melatonin. The results suggest that the potentiating effect of melatonin on the EFS-evoked response of the juvenile rat tail artery depends on degree of the change in the artery reactivity and was not due to change in sensitivity of postjunctional membrane to noradrenaline.
Karachentseva
O V
OV
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
Iartsev
V N
VN
Dvoretskiĭ
D P
DP
Zhdanova
I V
IV
D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000294:innervation; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D009129:Muscle Tonus / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000294:innervation*; D009599:Nitroprusside / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013623:Tail / Q000098:blood supply; D014661:Vasoconstriction / Q000187:drug effects*
D009599:Nitroprusside; D008550:Melatonin; D009638:Norepinephrine
Vliianie melatonina na neĭrogennuiu vasoreaktivnost': usloviia formirovaniia i moduliatsii sosudistykh otvetov.