title: Humoral immune response in adult blue foxes (Alopex lagopus) after oral infection with Encephalitozoon cuniculi spores.
abstract: Encephalitozoon cuniculi causes severe diseases in blue fox puppies. When pregnant vixens are infected, parasites are transmitted over the placenta to the unborn that subsequently develop encephalitozoonosis. Adult foxes themselves do not have signs of disease, but show antibody titres to E. cuniculi. The purpose of the present study was to gain information on the immune response in adult foxes after experimental infection. Sixteen foxes were infected orally with E. cuniculi spores, eight of them twice and 28 days apart. The two groups of animals showed elevated serological values in both the carbon immunoassay and in the ELISA. Elevated serological levels were recorded up to 1 year after the infection took place. The control group (n=8) remained serologically negative throughout the trial. The results of the study showed that blue foxes could be seropositive for at least a year after oral infection with E. cuniculi.
authors.affiliation: National Veterinary Institute, P.O. Box 8156 Dep., NO-0033, Oslo, Norway. johan.akerstedt@vetinst.no
authors.forename: Johan
authors.initials: J
authors.lastname: Akerstedt
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood / Q000276:immunology; D015153:Blotting, Western / Q000662:veterinary; D009670:Encephalitozoon cuniculi / Q000254:growth & development*; D016890:Encephalitozoonosis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D019085:Fluorescent Antibody Technique, Direct / Q000662:veterinary; D005589:Foxes / Q000276:immunology* / Q000469:parasitology*; D008297:Male
chemical_list: D000913:Antibodies, Protozoan