title: Is interval medication a successful treatment regimen for schizophrenic patients with critical attitudes towards treatment?
abstract: In neuroleptic long-term medication, only part of the patients accept regular intake of neuroleptic drugs. The question is whether an interval medication regimen as opposed to continuous medication can help to reduce drop outs in patients with critical attitudes towards long-term medication. In a 2-year prospective study, 122 patients were randomised to an interval and 164 to a continuous neuroleptic medication regimen. The drop out rates were 62.5% in the interval and 53.7% in the continuous medication group. Drop outs generally show more negative attitudes towards treatment. Patients with negative attitudes do not do better under interval medication. Moreover, this regimen even requires more cooperation and trust in terms of the necessity of medication on the part of the patient compared to the continuous medication regimen. Interval medication therefore is a strategy which can only be successful in highly cooperative, but not in treatment-reluctant patients.
authors.affiliation: Klinik für Psychiatrie und Psychotherapie, Campus Charité, Mitte, Schumannstrasse 20/21, 10117 Berlin, Germany. f.godemann@alexiu.de
authors.forename: F
authors.initials: F
authors.lastname: Godemann
authors.forename: M
authors.initials: M
authors.lastname: Linden
authors.forename: W
authors.initials: W
authors.lastname: Gaebel
authors.forename: W
authors.initials: W
authors.lastname: Köpke
authors.forename: P
authors.initials: P
authors.lastname: Müller
authors.forename: F
authors.initials: F
authors.lastname: Müller-Spahn
authors.forename: J
authors.initials: J
authors.lastname: Tegeler
authors.forename: A
authors.initials: A
authors.lastname: Pietzcker
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002908:Chronic Disease; D004334:Drug Administration Schedule; D006801:Humans; D010349:Patient Compliance / Q000523:psychology*; D011446:Prospective Studies; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents