Formal synthesis of (+)-discodermolide.
[structure: see text] Herein we report the formal total synthesis of (+)-discodermolide in 21 steps (longest linear sequence) from commercially available Roche ester. This synthesis features the assembly of C(9-18) and C(19-24) fragments via a metal-chelated aldol coupling reaction.
Francavilla
Charles
C
Novartis Pharmaceuticals Corporation, Oncology Research, 556 Morris Avenue, Summit, New Jersey 07901, USA.
Chen
Weichun
W
Kinder
Frederick R
FR
D000473:Alkanes; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002219:Carbamates; D007783:Lactones / Q000138:chemical synthesis*; D011161:Porifera / Q000737:chemistry; D011753:Pyrones; D013237:Stereoisomerism
D000473:Alkanes; D000970:Antineoplastic Agents; D002219:Carbamates; D007783:Lactones; D011753:Pyrones; C071229:discodermolide