title: A porous polymer scaffold for meniscal lesion repair--a study in dogs.
abstract: Meniscal lesions often occur in the avascular area of the meniscus with little chance of spontaneous repair. An access channel in the meniscal tissue can function as an entrance for ingrowing repair tissue from the vascular periphery of the meniscus to the lesion in the avascular zone which again induced healing of the lesion. Implantation of a porous polymer in a full-thickness access channel induced healing. However, a better integration between meniscal tissue and the implant might be achieved with the combination of the newly developed porous polymers and a modified surgical technique. This might improve meniscal lesion healing and the repair of the access channel with neo-meniscal tissue. Longitudinal lesions were created in the avascular part of 24 canine lateral menisci and a partial-thickness access channel was formed to connect the lesion with the meniscal periphery. In 12 menisci, the access channel was left empty (control group), while in the remaining 12 menisci the polymer implant was sutured into the access channel. Repair of the longitudinal lesions was achieved with and without polymer implantation in the partial-thickness access channel. Polymer implants induced fibrous ingrowth with cartilaginous areas, which resembled neo-meniscal tissue. Implantation did not prevent articular cartilage degeneration.
authors.affiliation: Department of Orthopaedics, Orthopaedic Research Laboratory, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: T G
authors.initials: TG
authors.lastname: Tienen
authors.forename: R G J C
authors.initials: RG
authors.lastname: Heijkants
authors.forename: P
authors.initials: P
authors.lastname: Buma
authors.forename: J H
authors.initials: JH
authors.lastname: De Groot
authors.forename: A J
authors.initials: AJ
authors.lastname: Pennings
authors.forename: R P H
authors.initials: RP
authors.lastname: Veth
mesh_terms: D000818:Animals; D046508:Culture Techniques; D004285:Dogs; D005260:Female; D008297:Male; D008592:Menisci, Tibial / Q000473:pathology* / Q000601:surgery*; D011091:Polyesters / Q000737:chemistry*; D019736:Prostheses and Implants; D019651:Plastic Surgery Procedures / Q000379:methods*; D000070600:Tibial Meniscus Injuries; D016896:Treatment Outcome
chemical_list: D011091:Polyesters; C062968:lactide-caprolactone copolymer