title: [Patterns of cerebral blood flow reactivity in adenosine stress-test in patients with carotid stenosis evaluated with MRI and emission tomography with 99m Tc-HMPAO].
abstract: In this study we evaluated the adenosine stress-test combined with 99mTc-HMPAO SPECT as a possible tool for evaluation of brain perfusion reserve in patients with various degrees of cortical neurologic damage due to internal carotid artery stenosis. The investigation comprised 37 patients with atherosclerotic carotid disease, in everybody of whom the stenosis was detected by echo-Doppler study of carotids and later in 28 verified also using invasive intraarterial digital subtractive angiography. In everybody the 99mTc-HMPAO SPECT study was performed twice: at rest and during stress-test with intravenous injection of adenosine with the patient in the supine position. It was gathered three groups of patients with different kinds of cerebral blood flow reactivity in adenosine stress-test. Henceforth, we conclude that, first, the 99mTc-HMPAO SPECT adenosin stress challenge of cerebral blood flow is a reliable functional test for every group of patients with extensive atherosclerosis and can be used for detection of patients with exhausted or decreased cerebral perfusion reserve in whom the risk of future cerebral vascular ischaemic events is elevated.
authors.affiliation: Tomsk Institute of Cardiology, Tomsk.
authors.forename: W Iu
authors.initials: WIu
authors.lastname: Ussov
authors.forename: V E
authors.initials: VE
authors.lastname: Sinitsyn
authors.forename: V
authors.initials: V
authors.lastname: Obradovic
authors.forename: G
authors.initials: G
authors.lastname: Dragutinovic
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Efimova
authors.forename: M P
authors.initials: MP
authors.lastname: Plotnikov
authors.forename: R S
authors.initials: RS
authors.lastname: Karpov
mesh_terms: D000241:Adenosine; D017536:Carotid Artery, Common; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000601:surgery; D002560:Cerebrovascular Circulation; D015150:Echocardiography, Doppler; D025401:Echocardiography, Stress; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008955:Models, Cardiovascular; D008959:Models, Neurological; D019275:Radiopharmaceuticals; D012307:Risk Factors; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D000241:Adenosine
vernacular_title: Otsenka reaktivnosti krovotoka golovnogo mozga s pomoshch'iu adenozinovoĭ proby u patsientov so stenozom sonnykh arteriĭ, po dannym MRT i émissionnoĭ tomografii s 99m Tc-GMPAO.