Elevated anticardiolipin antibodies in acute liver failure.
Antibodies to cardiolipin (aCLA), a phospholipid primarily localized in inner mitochondrial membranes, were transiently elevated (P<0.01) when mice were exposed to an industrial surfactant and then infected with influenza B virus, a model of acute liver failure (ALF). Children with ALF also had elevated levels of aCLA.
Rozee
K R
KR
Department of Microbiology and Immunology, Dalhousie University, Nova Scotia, B3H 4H7, Halifax, Canada.
Acott
P
P
Lee
S H S
SH
Crocker
J F S
JF
Gough
D
D
MacDonald
J
J
Evans
J
J
Murphy
M G
MG
D000818:Animals; D000831:Animals, Newborn; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D002308:Cardiolipins / Q000276:immunology*; D002648:Child; D004195:Disease Models, Animal; D006801:Humans; D008099:Liver / Q000473:pathology / Q000648:ultrastructure; D017114:Liver Failure, Acute / Q000097:blood / Q000276:immunology* / Q000473:pathology; D051379:Mice
D017153:Antibodies, Anticardiolipin; D002308:Cardiolipins