title: Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in Apc(Min) mice through different mechanisms.
abstract: We evaluated the effects of diet on intestinal tumorigenesis in male Apc(Min) mice by comparing AIN-76A diet fed ad libitum (CON); calorie intake restricted by 40% of the CON (CR); diet high in olive oil and supplemented with freeze-dried fruit and vegetable extracts (OFV); and diet high in total fat (HF). Compared with CON, the frequency of intestinal polyps was reduced by 57% by CR (P < 0.001) and by 33% OFV diet (P = 0.04). Both effective interventions reduced total body weight, lean mass, and fat mass and increased daily urinary corticosterone output, but only CR reduced serum insulin-like growth factor I and leptin. We conclude that dietary interventions can partially offset genetic susceptibility to intestinal carcinogenesis.
authors.affiliation: Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892-7105, USA.
authors.forename: Volker
authors.initials: V
authors.lastname: Mai
authors.forename: Lisa H
authors.initials: LH
authors.lastname: Colbert
authors.forename: David
authors.initials: D
authors.lastname: Berrigan
authors.forename: Susan N
authors.initials: SN
authors.lastname: Perkins
authors.forename: Ruth
authors.initials: R
authors.lastname: Pfeiffer
authors.forename: Jackie A
authors.initials: JA
authors.lastname: Lavigne
authors.forename: Elaine
authors.initials: E
authors.lastname: Lanza
authors.forename: Diana C
authors.initials: DC
authors.lastname: Haines
authors.forename: Arthur
authors.initials: A
authors.lastname: Schatzkin
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Hursting
mesh_terms: D000818:Animals; D001823:Body Composition / Q000502:physiology; D001835:Body Weight; D003345:Corticosterone / Q000652:urine; D004032:Diet; D002149:Energy Intake; D017491:Genes, APC; D020022:Genetic Predisposition to Disease; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007414:Intestinal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D007417:Intestinal Polyps / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control; D020738:Leptin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D020738:Leptin; D007334:Insulin-Like Growth Factor I; D003345:Corticosterone