Severe palmo-plantar hyperkeratosis in Koebner epidermolysis bullosa simplex.
A 22-year-old Japanese woman with Koebner epidermolysis bullosa simplex presented with severe palmo-plantar hyperkeratosis. Skin biopsy specimens from the palm revealed hyperkeratosis and acanthosis with blistering in the basal cell layer. An electron microscopic study showed cytolysis of basal cells and clumping of tonofilaments forming thick bundles and perinuclear electron-dense bodies. Hand contractures were released and covered with full thickness autografts or split thickness autografts. The donor site was successfully treated with cultured epidermal autografts.
Shirakata
Yuji
Y
Department of Dermatology, Ehime University School of Medicine, Japan.
Tamai
Katsuto
K
Nakaoka
Hiroki
H
Tokumaru
Sho
S
Sayama
Koji
K
Murakami
Shinji
S
Hashimoto
Koji
K
D000328:Adult; D016110:Epidermolysis Bullosa Simplex / Q000150:complications* / Q000473:pathology; D005260:Female; D006227:Hand Deformities, Acquired / Q000209:etiology / Q000601:surgery; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000473:pathology