Cyclin D in left ventricle hypertrophy.
Left ventricle hypertrophy is induced by a number of stimuli and can lead to cardio-myopathy and heart failure. The hypertrophic response is achieved by enlargement of the cardiac myocytes and is regulated by multiple signaling pathways, with the D-type cyclins playing a crucial role. Induction of cyclin D in adult cardiac myocytes leads to activation of cyclin-dependent kinases 4 and 6 and a partial progress through the cell cycle. Therefore, these pathways are attractive therapeutic target for treatment of heart failure and hypertrophy. We discuss the activity of cyclin D and other cell cycle regulatory proteins in left ventricle hypertrophy and whether the hypertrophic signaling pathways converge at the D-type cyclins.
Busk
Peter K
PK
Laboratoriet for Molekylaer Kordiologi, Medicinsk Afdeling B, Rigshosphalet. 20, Juliane Muriesvej, DK-2100 Copenhagen Ø, Denmark. busk@molheart.dk.
Hinrichsen
Rebecca
R
D000328:Adult; D019938:Cyclin D1 / Q000502:physiology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology*; D008954:Models, Biological; D015398:Signal Transduction
D019938:Cyclin D1