Dyskeratosis congenita associated with three malignancies.
Dyskeratosis congenita is a rare inheritable disorder characterized by abnormalities of the skin, nails and oral mucosa. Aplastic anaemia resulting from bone marrow hypoplasia is a frequent cause of death. Squamous cell carcinoma developing from leukoplakia and visceral malignancies are other complications of the disease. We report here a case of dyskeratosis congenita in a man who developed three neoplasias of different systems over a period of many years. Squamous cell carcinoma and gastric adenocarcinoma manifested 17 years after the man was diagnosed with Hodgkin's disease.
Baykal
C
C
Istanbul University, Istanbul Medical School, Department of Dermatology Istanbul, Turkey. baykalc@istanbul.edu.tr
Kavak
A
A
Gülcan
P
P
Büyükbabani
N
N
D000230:Adenocarcinoma / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D019871:Dyskeratosis Congenita / Q000150:complications*; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000150:complications*; D010859:Pigmentation Disorders / Q000150:complications*; D013274:Stomach Neoplasms / Q000150:complications*