title: Aberrant immunophenotypes of mantle cell lymphomas.
abstract: Mantle cell lymphomas (MCL) are characterized by cytomorphological criteria, a distinct immunophenotype and a characteristic chromosomal aberration (t(11;14)). In morphological variants of MCL the immunohistochemical constellation with CD5-positivity and CD23-negativity is a helpful and decisive diagnostic aid to differentiate MCL from other B-cell-lymphomas, e.g. lymphocytic lymphomas (B-CLL). In this study the morphological, immunophenotypical, and genetical features of 50 MCL were analysed. Five cases revealed an aberrant immunophenotype with lacking expression of CD5 (n = 3) and positive reactivity to CD23 (n = 2) while cyclin D1 expression could be demonstrated in all 5 cases. These constellations show that there is, besides morphological subgroups, a small group of MCL with aberrant immunophenotypes, which has to be taken into account in the differential diagnosis to lymphocytic lymphoma and other lymphomas.
authors.affiliation: Institute of Pathology, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.
authors.forename: Ch
authors.initials: Ch
authors.lastname: Wohlschlaeger
authors.forename: K
authors.initials: K
authors.lastname: Lange
authors.forename: H
authors.initials: H
authors.lastname: Merz
authors.forename: A C
authors.initials: AC
authors.lastname: Feller
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis*; D018956:CD5 Antigens / Q000032:analysis; D019938:Cyclin D1 / Q000032:analysis; D005260:Female; D019940:Genes, bcl-1; D019254:Genes, bcl-2; D006801:Humans; D016130:Immunophenotyping; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D017455:Receptors, IgE / Q000032:analysis; D014178:Translocation, Genetic
chemical_list: D015703:Antigens, CD; D018956:CD5 Antigens; D017455:Receptors, IgE; D019938:Cyclin D1