title: Transformation of a MGUS to overt multiple myeloma: the possible role of a pituitary macroadenoma secreting high levels of insulin-like growth factor 1 (IGF-1).
abstract: We present a female patient with monoclonal gammopathy of undetermined significance who has remained stable for five years but evolved to overt myeloma in strict temporal relationship with the diagnosis of GH-secreting pituitary macroadenoma. IGF-I serum levels correlated with serum and urine M component. Since the in vitro role of IGF-I on proliferation and survival of normal and neoplastic plasma cells has been recently emphasized, the pathogenetic link between acromegaly and transformation of gammopathy to overt myeloma in this case is discussed.
authors.affiliation: Sezione di Ematologia, Spedali Civili, P.le Spedali Civili 1, 25125 Brescia, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Tucci
authors.forename: Stefania
authors.initials: S
authors.lastname: Bonadonna
authors.forename: Chiara
authors.initials: C
authors.lastname: Cattaneo
authors.forename: Marco
authors.initials: M
authors.lastname: Ungari
authors.forename: Andrea
authors.initials: A
authors.lastname: Giustina
authors.forename: Rossi
authors.initials: R
authors.lastname: Guiseppe
mesh_terms: D000236:Adenoma / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy; D000368:Aged; D002470:Cell Survival; D003131:Combined Modality Therapy; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D009101:Multiple Myeloma / Q000209:etiology*; D009194:Myeloma Proteins / Q000032:analysis; D009378:Neoplasms, Multiple Primary; D015282:Octreotide / Q000627:therapeutic use; D010265:Paraproteinemias / Q000150:complications*; D010456:Peptides, Cyclic / Q000627:therapeutic use; D010911:Pituitary Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy; D010950:Plasma Cells / Q000473:pathology; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D009194:Myeloma Proteins; D010456:Peptides, Cyclic; C060347:lanreotide; D019382:Human Growth Hormone; D013004:Somatostatin; D007334:Insulin-Like Growth Factor I; D015282:Octreotide