Microwave-assisted synthesis of O'-adamantylated uracil-derived nucleosides.
Microwave-induced synthesis of O'-adamantyl derivatives of AZT, thymidine, 2'-deoxyuridine and uridine was investigated. Contrary to heterocyclus adamantylation of uracil and uridine in trifluoroacetic acid, the microwave-induced reaction provided sugar-substituted compounds.
Górska
Agata
A
Institute of Chemistry, Agricultural University, Warsaw, Poland.
Andrzejewska
Mariola
M
Kamiński
Jarosław
J
Kazimierezuk
Zygmunt
Z
D000218:Adamantane / Q000031:analogs & derivatives* / Q000737:chemistry; D003857:Deoxyuridine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D018840:HSP70 Heat-Shock Proteins; D006358:Hot Temperature; D008872:Microwaves; D018832:Molecular Chaperones; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D029701:Saccharomyces cerevisiae Proteins; D013936:Thymidine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D014498:Uracil / Q000031:analogs & derivatives; D015215:Zidovudine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry
C480506:3'-5'-di-O-(1-adamantyl)-2'-deoxyuridine; C480505:3'-5'-di-O-(1-adamantyl)-thymidine; C480501:5'-O-(1-adamantyl)-3'-azido-3'-deoxythymidine; C480502:5'-O-(1-adamantyl)-thymidine; D018840:HSP70 Heat-Shock Proteins; D018832:Molecular Chaperones; D009705:Nucleosides; C424445:SSZ1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D015215:Zidovudine; D014498:Uracil; C434445:1-adamantanol; D000218:Adamantane; D013936:Thymidine; D003857:Deoxyuridine