CD4+CD25+ T cells as key regulators of immune responses.
Discredited a few years ago, active suppression is now commonly considered as a key mechanism avoiding auto-reactivity and development of potentially harmful immune responses, and in some circumstances, as an obstacle to successful vaccination. A large quantity of literature identifies naturally occurring CD4+CD25+ T cells as key suppressor cells involved in the control of many pathophysiological diseases. Manipulation of these cells and control of their function offers new perspectives for the treatment of auto-immune and inflammatory diseases and enhancement of vaccine efficacy. Such clinical interventions require a better understanding of the conditions of expansion/activation of CD4+CD25+ T cells and deciphering of their mechanism of suppression, which remains incomplete and sometimes controversial.
Dubois
Bertrand
B
INSERM U404, CERVI-IFR74, 21, avenue Tony Garnier, 69365 Lyon cedex 07, France. dubois@cervi-lyon.inserm.fr
Chapat
Ludivine
L
Goubier
Anne
A
Kaiserlian
Dominique
D
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D003877:Dermatitis, Contact / Q000276:immunology; D006801:Humans; D007109:Immunity / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D015375:Receptors, Interleukin-2