[Effect of quercetin on sodium diclofenac-induced ulceration].
Effect was studied of quercetin on experimentally induced injuries of the gastric mucosa. The animals were divided into 4 groups: in group I animals, the placebo solution of diclofenac sodium was administered; in group II animals, the solution of diclofenac sodium was administered in a dose of 25 mg/kg intragastrally with the aid of a specific probe, group III animals were given quercetin perorally, 100 mg/kg for up to three days, with diclofenac sodium to follow, group IV animals (treatable group) received the same dose of quercetin for up to three days after a single administration of diclofenac sodium. At the end of the experiment the animals died from the overdosage of ether. The peoral use of quercetin before and after administration of diclofenac sodium has been shown to be associated with fewer ulcers in test animals, which fact suggests to us a protective effect of quercetin on their gastric mucosa.
Zahorodnyĭ
M I
MI
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004008:Diclofenac; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D011794:Quercetin / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D004008:Diclofenac; D011794:Quercetin
Vplyv kvertsetynu na ul'tserohennyĭ efekt dyklofenaku natriiu.