title: [Modern aspects in the treatment of ophthalmic herpes].
abstract: The author report about study results conducted in Russia during the recent 30 years and dedicated to the treatment of ocular pathologies caused by the virus of herpes simplex. Three high-efficiency directions took shape during the mentioned period: 1. Non-specific antiviral therapy based on the local and systemic administration of interferon inductors (poludan--complexes of poly A, poly U etc.) possessing an extensive spectrum of the antiviral and immune-modeling actions; 2. Antirecurrent therapy, including the application of herpetic vaccine against the virus of herpes simplex, types I and II, combined with immune-modeling agents. A focal allergic test with herpetic vaccine was offered, it made it possible, for the first time, a non-invasive diagnostics of intraocular herpes. 3. A system of sparing microsurgical methods adapted to the treatment of an active herpetic keratitis and its outcomes. A synergistic effect of interferon inductors and acyclovir was proven both experimentally and clinically; a method of local autocytokinotherapy (based on poludan), which turned out to be most effective in the treatment of severe lesions at the cornea and of intraocular herpes, was worked out. The authors believe that the methods and means offered for the treatment of ophthalmoherpes contribute, to a great extent, to handling with the ocular herpes viral infection.
authors.forename: A A
authors.initials: AA
authors.lastname: Kasparov
authors.forename: O K
authors.initials: OK
authors.lastname: Vorob'eva
authors.forename: E A
authors.initials: EA
authors.lastname: Kasparova
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D005123:Eye; D006563:Herpes Zoster Ophthalmicus / Q000188:drug therapy*; D022283:Herpesvirus Vaccines / Q000008:administration & dosage*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D009824:Ointments; D009883:Ophthalmic Solutions; D011131:Polyribonucleotides / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D022283:Herpesvirus Vaccines; D009824:Ointments; D009883:Ophthalmic Solutions; D011131:Polyribonucleotides; C044366:poludan; D000212:Acyclovir
vernacular_title: Sovremennye aspekty lecheniia oftal'mogerpesa.