title: Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists.
abstract: A series of acyclic phenethylthiocarbamate derivatives have been synthesized, and their antagonist effect against vanilloid receptor tested. Chain branching led to a significant change in antagonist activity of the parent molecule. Ethyl-branched 1e showed a 6.3 microM of IC(50) value in 45Ca(2+)-influx assay.
authors.affiliation: College of Pharmacy, Sookmyung Women's University, 53-12 Chungpa-dong, Yongsan-ku, Seoul 140-742, South Korea.
authors.forename: JungWha
authors.initials: J
authors.lastname: Yoon
authors.forename: HyeYoung
authors.initials: H
authors.lastname: Choi
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Lee
authors.forename: Chong Hyun
authors.initials: CH
authors.lastname: Ryu
authors.forename: Hyeung-geun
authors.initials: HG
authors.lastname: Park
authors.forename: Young-ger
authors.initials: YG
authors.lastname: Suh
authors.forename: Uhtaek
authors.initials: U
authors.lastname: Oh
authors.forename: Yeon Su
authors.initials: YS
authors.lastname: Jeong
authors.forename: Jin Kyu
authors.initials: JK
authors.lastname: Choi
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Park
authors.forename: Hee-Doo
authors.initials: HD
authors.lastname: Kim
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D002478:Cells, Cultured; D009475:Neurons, Afferent / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011955:Receptors, Drug / Q000819:agonists / Q000037:antagonists & inhibitors*; D013116:Spinal Cord / Q000166:cytology; D013329:Structure-Activity Relationship; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D011955:Receptors, Drug; D013859:Thiocarbamates; C071423:capsazepine; D002211:Capsaicin; D002118:Calcium