title: [Analysis of signal transduction pathways in cerebellar long-term depression by use of kinetic simulations].
abstract: It is essential to analyze molecular basis of synaptic plasticity systematically for understanding our psychological processes and psychological disorders. Recent progress identified many signaling molecules responsible for the regulation of synaptic plasticity. However, because multiple molecular signal transduction molecules and pathways are involved, the systematic relationship between synaptic plasticity and the currently known signal transduction pathways remains obscure. To address this issue, we here focused on cerebellar long-term depression (LTD), one of the well known synaptic plasticity. We took advantage of a simulation model for cerebellar LTD based on biochemical reactions, kinetics, and explored the behaviors of complex signal transduction pathways involved in cerebellar LTD.
authors.affiliation: Undergraduate Program for Bioinformatics and Systems Biology, Graduate School of Information Science and Technology, University of Tokyo.
authors.forename: Shinya
authors.initials: S
authors.lastname: Kuroda
mesh_terms: D002525:Cerebellar Cortex / Q000502:physiology*; D023902:Chromosome Pairing / Q000502:physiology; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*