title: 1,4-thiazepines, 1,4-benzothiazepin-5-ones, and 1,4-benzothioxepin orthoamides via multicomponent reactions of isocyanides.
abstract: The intramolecular Ugi four-component condensation between 6-oxo-4-thiacarboxylic acids, benzylamines, and cyclohexyl isocyanide gave hexahydro-1,4-thiazepin-5-ones and 1,4-benzothiazepin-5-ones, in some cases with high stereoselectivity, and the intramolecular Passerini three-component reaction, in the presence of catalytic amine, gave tetracyclic 1,4-benzothioxepin orthoamides.
authors.affiliation: Dipartimento di Chimica Organica Ugo Schiff, Università di Firenze, 50019-Sesto Fiorentino, Florence, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Marcaccini
authors.forename: Daniel
authors.initials: D
authors.lastname: Miguel
authors.forename: Tomás
authors.initials: T
authors.lastname: Torroba
authors.forename: María
authors.initials: M
authors.lastname: García-Valverde