Intraperitoneal fluid accumulation induced by Clostridium perfringens alpha-toxin (phospholipase C).
We report that the intraperitoneal injection of Clostridium perfringens alpha-toxin into mice induces ascites. This phenomenon was monitored by measuring fluid volume and analyzing hematologic data. The mouse toxicity test provides a simple and useful model for examining C. perfringens alpha-toxin-induced vascular permeability.
Maegawa
Tsuneo
T
Department of Bacteriology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan.
Wang
Xingmin
X
Karasawa
Tadahiro
T
Zuka
Masahiko
M
Kita
Hiroyuki
H
Nakamura
Shinichi
S
D000818:Animals; D001201:Ascites / Q000209:etiology*; D001427:Bacterial Toxins / Q000633:toxicity*; D002135:Calcium-Binding Proteins; D002199:Capillary Permeability / Q000187:drug effects; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D051379:Mice; D010738:Type C Phospholipases / Q000633:toxicity*
D001427:Bacterial Toxins; D002135:Calcium-Binding Proteins; D006454:Hemoglobins; D010738:Type C Phospholipases; C040649:alpha toxin, Clostridium perfringens