title: Synthesis of novel acetylene-containing amino acids.
abstract: Novel synthetic procedures for the modification of non-proteinogenic acetylene-containing amino acids have been developed. The functionalization either proceeds via zinc/copper-mediated introduction of alkyl substituents, or via tungsten-catalyzed ring-closing alkyne metathesis reactions.
authors.affiliation: Department of Organic Chemistry, University of Nijmegen, Toernooiveld 1, NL 6525 ED Nijmegen, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: IJsselstijn
authors.forename: J
authors.initials: J
authors.lastname: Kaiser
authors.forename: F L
authors.initials: FL
authors.lastname: van Delft
authors.forename: H E
authors.initials: HE
authors.lastname: Schoemaker
authors.forename: F P J T
authors.initials: FP
authors.lastname: Rutjes
mesh_terms: D000114:Acetylene / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D008956:Models, Chemical; D015032:Zinc / Q000737:chemistry
chemical_list: D000596:Amino Acids; D003300:Copper; D015032:Zinc; D000114:Acetylene