title: Effects of heavy alcohol consumption on the cardiovascular system may be mediated in part by the influence of alcohol-induced depression on the immune system.
abstract: The harmful effects of heavy alcohol use are well-documented and wide-ranging. Heavy drinking may cause or exacerbate cardiovascular disorders. The author suggests that effects of heavy alcohol consumption on the cardiovascular system may be mediated in part by the influence of alcohol-induced depression on the immune system. This hypothesis is based on the following data: (1) alcohol misuse may cause or exacerbate depression; (2) depressive disorders are associated with increased incidence, morbidity, and mortality of cardiovascular disorders; (3) the immune system may mediate effects of depressive disorders on the cardiovascular system. Further studies are needed to clarify the etiopathogenesis of alcohol-related disorders and develop new treatment modalities.
authors.affiliation: Fort Lee, New Jersey, USA. drleosher@aol.com
authors.forename: Leo
authors.initials: L
authors.lastname: Sher
mesh_terms: D000428:Alcohol Drinking; D002319:Cardiovascular System / Q000187:drug effects*; D003863:Depression / Q000139:chemically induced* / Q000276:immunology; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D007107:Immune System / Q000187:drug effects*
chemical_list: D000431:Ethanol