[New photosensitizers of bacteriochlorin series for photodynamic cancer therapy].
New derivatives of bacteriochlorophyll a bearing an extra glutarimide exocycle were synthesized, and their reactivity was studied. Acetyl group in 3-acetyl-2,7,12,18-tetramethyl-8-ethyl-13,15- dicarboxy-17-carboxyethyl-7,8,17,18-tetrahydroporphyrin (bacteriochlorin p) was chemically modified into alpha-hydroxyethyl and vinyl groups. A simple method of preparation of vinylbacteriopurpurin esters under the catalysis by p-toluenesulfonic acid was proposed. The resulting compounds exhibit a high adsorption in the visible and near IR areas of electronic spectra, a reasonable stability, and amphiphilic properties and, therefore, may be regarded as promising photosensitizers for the photodynamic cancer therapy.
Mironov
A F
AF
Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 119571 Russia. httos.mitht@g.23.relcom.ru
Grin
M A
MA
Tsiprovskiĭ
A G
AG
Segenevich
A V
AV
Dzardanov
D V
DV
Golovin
K V
KV
Tsygankov
A A
AA
Shim
Ya K
YK
D025541:Bacteriochlorophyll A / Q000737:chemistry; D001671:Biochemistry / Q000379:methods; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009369:Neoplasms / Q000628:therapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011166:Porphyrins / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D025541:Bacteriochlorophyll A; D017319:Photosensitizing Agents; D011166:Porphyrins; C452433:bacteriochlorin
Novye fotosensibilizatory bakteriokhlorinovogo riada dlia fotodinamicheskoĭ terapii raka.