The effect of anabolic steroids on mandibular growth.
The aim of this study was to assess the effect of nandrolone (Deca-Durabolin, AKZO Nobel, Cambridge, United Kingdom) on mandibular growth in juvenile and adult rats with radiographic cephalometry and immunoradiology. Juvenile (n = 16) and adult (n = 16) inbred female Wistar-Kyoto rats were compared. Each group was divided into 2 subgroups with 8 experimental (E) and 8 control (C) animals in each subgroup. Lateral headfilms taken before and after the 70-day study period were analyzed. Body weight and blood serum IGF-I levels were monitored weekly. The results showed marked mandibular growth changes in both the juvenile and the adult E rats. Body weight increase was larger in the E than in the C animals. The IGF-I blood serum levels were similar in the juvenile E and C rats but higher in the adult E animals than in the adult C animals. It was found that the anabolic steroid (Deca-Durabolin) had a significant effect on mandibular growth in both juvenile and adult rats.
Gebhardt
Alexander
A
Department of Orthodontics, University of Giessen, Germany.
Pancherz
Hans
H
D000367:Age Factors; D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight; D002508:Cephalometry; D003724:Dental Arch / Q000187:drug effects / Q000254:growth & development; D005260:Female; D007091:Image Processing, Computer-Assisted; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008334:Mandible / Q000187:drug effects* / Q000254:growth & development; D009277:Nandrolone / Q000494:pharmacology*; D051381:Rats; D011921:Rats, Inbred WKY; D018709:Statistics, Nonparametric
D045930:Anabolic Agents; D007334:Insulin-Like Growth Factor I; D009277:Nandrolone