Copper-tyrosyl radical enzymes.
Advances have been made since 2000 that contribute to our understanding of the biogenesis, structure and mechanism of copper-containing tyrosyl radical enzymes. Efforts to detail the biogenesis of galactose oxidase have produced the structure of the precursor enzyme, which provides a framework for emerging mechanistic studies. The role of the tyrosyl radical of cytochrome c oxidase is being defined in studies that aim to understand the His-Tyr crosslink, the location of the radical and, by direct attempts, to provide evidence for the radical during turnover.
Rogers
Melanie S
MS
Department of Chemistry and Biochemistry, Gaines Hall, Montana State University, Bozeman, MT 59717, USA. mrogers@copper.chemistry.montana.edu
Dooley
David M
DM
D002384:Catalysis; D003300:Copper / Q000378:metabolism*; D003432:Cross-Linking Reagents; D003576:Electron Transport Complex IV / Q000378:metabolism; D004798:Enzymes / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism; D005692:Galactose Oxidase / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism*
D003432:Cross-Linking Reagents; D004798:Enzymes; D005609:Free Radicals; D014443:Tyrosine; D003300:Copper; D005692:Galactose Oxidase; D003576:Electron Transport Complex IV