Synthesis of serine/alanine conjugated 3',5'-TpT.
Serine and alanine phosphoramidates conjugates of 3',5'-TpT 4, 5 were synthesized. The corresponding serine phosphoamidate possesses some unique properties due to the presence of the side chain hydroxyl group.
Qin
Zhi-Hui
ZH
Bioorganic Phosphorus Chemistry Laboratory, Department of Chemistry, School of Life Science and Engineering, Tsinghua University, Beijing, P.R. China.
Lin
Chang-Xue
CX
Ju
Yong
Y
Zhao
Yu-Fen
YF
D000409:Alanine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D000577:Amides / Q000737:chemistry*; D003853:Deoxyribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D063088:Phosphoramides; D010756:Phosphoric Acids / Q000737:chemistry*; D012694:Serine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
D000577:Amides; D003853:Deoxyribonucleosides; C480512:O-(5'-dimethoxytrityl-2'-deoxythmidin-3'-yl)-O'-(3'-acetyl-2'-deoxythymidin-5'-yl)-N-alanine methyl ester phosphoramidate; C480513:O-(5'-dimethoxytrityl-2'-deoxythmidin-3'-yl)-O'-(3'-acetyl-2'-deoxythymidin-5'-yl)-N-serin methyl ester phosphoramidate; C480511:O-(5'-dimethoxytrityl-2'-deoxythmidin-3'-yl)-O'-(3'-acetyl-2'-deoxythymidin-5'-yl)hydrogenphosphonate; D063088:Phosphoramides; D010756:Phosphoric Acids; C005438:phosphoramide; D012694:Serine; D000409:Alanine