Cooperation between memory systems: acetylcholine release in the amygdala correlates positively with performance on a hippocampus-dependent task.
The present experiment examined the relationship between release of acetylcholine (ACh) in the amygdala and performance on a hippocampus-dependent spatial working memory task. Using in vivo microdialysis, the authors measured ACh release in rats during testing on a spontaneous alternation task. Amygdala ACh release was positively correlated with performance on the hippocampus-dependent task. These findings suggest that activation of the amygdala promotes processing in other neural systems important for learning and memory.
McIntyre
Christa K
CK
Department of Neurobiology and Behavior, University of California, Irvine, USA.
Marriott
Lisa K
LK
Gold
Paul E
PE
D000109:Acetylcholine / Q000378:metabolism*; D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D005106:Exploratory Behavior / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism* / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D017551:Microdialysis; D011597:Psychomotor Performance / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000109:Acetylcholine