Enantioseparation of some clinically used drugs by HPLC using cellulose Tris (3,5-dichlorophenylcarbamate) chiral stationary phase.
The chiral resolution of some clinically used drugs namely metoprolol, teratolol, tolamolol, nebivolol (beta-adrenergic blockers), econazole, miconazole (anti-fungal agents), cromakalim (anti-hypertensive agent) and etodolac (anti-inflammatory agent) was achieved on cellulose tris (3,5-dichlorophenylcarbamate) chiral stationary phase. The mobile phase used was 2-propanol at 0.5 mL/min with detection at 220 nm. The separation factors (alpha) of these drugs ranged from 1.24 to 3.90 while the resolution factors were from 1.05 to 5.0. The chiral recognition mechanisms between the racemates and the chiral selector are discussed.
Ali
Imran
I
Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03-65), King Faisal Specialist Hospital and Research Center, PO Box 3354, Riyadh-11211, Saudi Arabia.
Aboul-Enein
Hassan Y
HY
D002219:Carbamates / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000097:blood / Q000302:isolation & purification*; D048448:Phenylcarbamates; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D002219:Carbamates; D004364:Pharmaceutical Preparations; D048448:Phenylcarbamates; C420325:cellulose tris(3,5-dichlorophenylcarbamate); D002482:Cellulose