title: Large-dose intravenous methotrexate-induced cutaneous toxicity: can oral magnesium oxide reduce pain?
abstract: Chemotherapy for cancer is associated with pain including cutaneous vasculitis. Magnesium, an N-methyl-D-aspartic acid-receptor antagonist, was used successfully to treat an adolescent with pain caused by cutaneous vasculitis secondary to methotrexate therapy.
authors.affiliation: Department of *Pediatric Anesthesiology, Children's Memorial Hospital, and †Department of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; and ‡Division of Anesthesiology, The Cleveland Clinic Foundation, Cleveland, Ohio.
authors.forename: Santhanam
authors.initials: S
authors.lastname: Suresh
authors.forename: Sara
authors.initials: S
authors.lastname: Lozono
authors.forename: Steven C
authors.initials: SC
authors.lastname: Hall
mesh_terms: D000008:Abdominal Neoplasms / Q000150:complications / Q000188:drug therapy; D000293:Adolescent; D000701:Analgesics, Opioid / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D002051:Burkitt Lymphoma / Q000150:complications / Q000188:drug therapy; D003875:Drug Eruptions / Q000150:complications*; D005260:Female; D005283:Fentanyl / Q000627:therapeutic use; D006801:Humans; D008277:Magnesium Oxide / Q000627:therapeutic use*; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D010147:Pain Measurement
chemical_list: D000701:Analgesics, Opioid; D000964:Antimetabolites, Antineoplastic; D008277:Magnesium Oxide; D005283:Fentanyl; D008727:Methotrexate