title: Massive hepatomegaly: a presenting manifestation of multiple myeloma.
abstract: We report a 50-year-old woman presenting with isolated massive hepatomegaly. Liver histology showed dilated sinusoids within which some atypical cells, probably of hematopoeitic origin, were identified. Bone marrow was densely packed with similar atypical cells with high nucleo-cytoplasmic ratio, which tested positive for plasma cell markers. Plasma protein electrophoresis showed a distinct M spike in the gamma globulin fraction and skeletal survey revealed multiple lytic lesions in the skull and pelvic bones. Thus, a final diagnosis of multiple myeloma was made. The patient has received six cycles of chemotherapy and is doing well.
authors.affiliation: Department of Medicine, Maulana Azad Medical College, New Delhi 110 002.
authors.forename: Anil
authors.initials: A
authors.lastname: Jain
authors.forename: P
authors.initials: P
authors.lastname: Chakraborty
authors.forename: Surinder Singh
authors.initials: SS
authors.lastname: Rana
authors.forename: A
authors.initials: A
authors.lastname: Kundra
authors.forename: Rohit
authors.initials: R
authors.lastname: Goyal
authors.forename: K
authors.initials: K
authors.lastname: Das
authors.forename: S
authors.initials: S
authors.lastname: Anuradha
authors.forename: P
authors.initials: P
authors.lastname: Kar
mesh_terms: D001797:Blood Protein Electrophoresis; D005260:Female; D006529:Hepatomegaly; D006801:Humans; D008099:Liver / Q000473:pathology; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology