Plasma fatty acids response to central volume expansion in salt-sensitive hypertension.
The purpose of the present study was to investigate the possible regulation of plasma fatty acids by an acute isotonic-isooncotic central volume expansion. We measured the levels of nonesterified fatty acids (NEFA) in plasma from 12 essential hypertensive patients subjected to water immersion (WI). Central hypervolemia by WI over 2 hours caused the levels of most NEFA to increase, concomitantly with a marked natriuretic and kaliuretic response. With respect to baseline values, serum insulin levels did not change during WI, while there was a profound suppression of plasma renin activity (PRA) and plasma aldosterone. In addition, when individual NEFA percent increase was expressed as a function of salt-sensitivity index (calculated as the change in mean arterial pressure [MAP] divided by the change in urinary sodium excretion rate), a greater percent increase in stearic acid (r =.72, P <.009), palmitic acid (r =.83, P <.001), and palmitoleic acid (r =.58, P <.048) was found during WI in those hypertensive subjects showing higher salt-sensitivity index. Thus, by demonstrating that an acute isotonic-isooncotic volume expansion may induce a significant increase of most NEFA plasma levels, we suggest that volume expansion per se could be included among the well-recognized risk factors for cardiovascular morbid events.
Coruzzi
Paolo
P
Istituto di Semeiotica Medica, Fondazione Don C.Gnocchi, ONLUS, Università di Parma, Italy.
Brambilla
Lorenzo
L
Brambilla
Valerio
V
Gualerzi
Massimo
M
Parati
Gianfranco
G
Di Rienzo
Marco
M
Zanardi
Emanuela
E
Novarini
Almerico
A
D000328:Adult; D000450:Aldosterone / Q000097:blood; D001810:Blood Volume / Q000502:physiology*; D003404:Creatinine / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000139:chemically induced; D007101:Immersion / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D010169:Palmitic Acids / Q000097:blood; D012083:Renin / Q000097:blood; D012964:Sodium / Q000652:urine; D012965:Sodium Chloride
D005230:Fatty Acids, Nonesterified; D007328:Insulin; D010169:Palmitic Acids; D012965:Sodium Chloride; D000450:Aldosterone; D012964:Sodium; D003404:Creatinine; D012083:Renin