title: Economics of prophylactic treatment.
abstract: Clinical studies have shown significant improvement in outcomes with the use of prophylactic treatment, as well as apparent gains in health-related quality of life. Given the high cost and still limited availability of factor concentrates, physicians, insurers and governments require cost-effectiveness data to evaluate competing treatments (eg prophylactic vs. on-demand treatment) and to set priorities within the context of each country's financial resources. To date, the few published studies of the cost-effectiveness of haemophilia prophylaxis have generally focused on the reduction in frequency of bleedings as an intermediate outcome, and not on long-term health outcomes, such as the development of arthropathy and its social and economic costs. Since all prophylactic measures are investments for the future, long-term economic consequences need to be carefully studied and evaluated.
authors.affiliation: University Hospital of Munich, Department of Haemostasis and Transfusion Medicine, Ziemssenstrasse 1, 80336 Munich, Germany. Wolfgang.Schramm@medinn.med.uni-muenchen.de
authors.forename: W
authors.initials: W
authors.lastname: Schramm
authors.forename: K
authors.initials: K
authors.lastname: Berger
mesh_terms: D017281:Cost of Illness; D003362:Cost-Benefit Analysis; D003657:Decision Making; D006467:Hemophilia A / Q000191:economics / Q000517:prevention & control*; D002836:Hemophilia B / Q000191:economics / Q000517:prevention & control*; D006801:Humans; D012106:Research