Chronological alterations of calbindin D-28k immunoreactivity in the gerbil main olfactory bulb after ischemic insult.
We investigated spatial and temporal alterations of calbindin D-28k (CB) immunoreactivity in the gerbil main olfactory bulb after transient ischemia-reperfusion. In sham-operated animals, CB-immunoreactive (IR) neurons were found in the periglomerular layer, external plexiform layer and granule cell layer. At 1-4 days after ischemic insult, the number of CB-IR neurons significantly increased. This result suggests that the increased CB may buffer the intracellular calcium at an early time point after the ischemic insult. In contrast, 10-30 days after the ischemic insult, the number of CB-IR neurons significantly decreased as compared to sham-operated animals. This result suggests that a malfunction in olfactory process may have occurred in the olfactory bulb at a later time point after the ischemic insult.
Hwang
In Koo
IK
Department of Anatomy, College of Medicine, Hallym University, Chunchon 200-702, South Korea.
Kang
Tae-Cheon
TC
Lee
Jae Chul
JC
Park
Seung-Kook
SK
An
Sung Jin
SJ
Lee
In Se
IS
Lee
Yoon-Bok
YB
Sohn
Heon-Soo
HS
Kang
Jung Hoon
JH
Choi
Soo Young
SY
Won
Moo Ho
MH
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D064026:Calbindins; D004195:Disease Models, Animal; D005849:Gerbillinae; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D009830:Olfactory Bulb / Q000378:metabolism* / Q000473:pathology*; D015427:Reperfusion Injury / Q000378:metabolism* / Q000473:pathology; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D013997:Time Factors
D064026:Calbindins; D064030:S100 Calcium Binding Protein G