Adherence to highly active antiretroviral therapy is better in patients receiving non-nucleoside reverse transcriptase inhibitor-containing regimens than in those receiving protease inhibitor-containing regimens.
The difference between adherence to non- nucleoside reverse transcriptase inhibitor (NNRTI) and protease inhibitor (PI)-based regimens was investigated. Better adherence was found in NNRTI-treated patients, especially when efavirenz was included in the regimen, compared with single PI-treated patients and in those with CD4 cell counts less than 200 x 10(6)/l. By contrast, younger age, self-report of active drug use, fatigue or vomiting negatively affected adherence. Self-reported sexual dysfunction was significantly associated with non-adherence only in PI-treated individuals.
Trotta
Maria Paola
MP
Istituto Nazionale per le Malattie Infettive, L. Spallanzani IRCCS, Rome, Italy.
Ammassari
Adriana
A
Cozzi-Lepri
Alessandro
A
Zaccarelli
Mauro
M
Castelli
Francesco
F
Narciso
Pasquale
P
Melzi
Sara
S
De Luca
Andrea
A
Monforte
Antonella D'Arminio
AD
Antinori
Andrea
A
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D005221:Fatigue / Q000139:chemically induced; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D012044:Regression Analysis; D012307:Risk Factors; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced; D019966:Substance-Related Disorders / Q000150:complications; D011795:Surveys and Questionnaires; D014839:Vomiting / Q000139:chemically induced
D017320:HIV Protease Inhibitors; D054303:HIV Reverse Transcriptase