title: Disseminated cytomegalovirus disease as a cause of prolonged fever in a bullous pemphigoid patient under systemic steroid therapy.
abstract: We present the first reported case of disseminated cytomegalovirus (CMV) in association with prednisone therapy in bullous pemphigoid (BP). A 66-year-old black male patient was admitted to our hospital presenting cutaneous pruritic lesions represented by tense blisters, with serous content on the arms, abdomen and legs. Laboratory findings confirmed the diagnosis of BP. After two weeks of prednisone therapy, the patient developed prolonged fever, which was caused by CMV disseminated disease, with prompt clinical recovery after ganciclovir administration.
authors.affiliation: Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.
authors.forename: Daniel Sesto
authors.initials: DS
authors.lastname: Casals
authors.forename: Eduardo de Azevedo
authors.initials: Ede A
authors.lastname: Nunes
authors.forename: Celina Wakisaka
authors.initials: CW
authors.lastname: Maruta
authors.forename: Valeria
authors.initials: V
authors.lastname: Aoki
authors.forename: Claudia Giuli
authors.initials: CG
authors.lastname: Santi
authors.forename: Marcello Menta
authors.initials: MM
authors.lastname: Simonsen Nico
authors.forename: Maria Cassia Mendes
authors.initials: MC
authors.lastname: Correa
authors.forename: Olavo Henrique Munhoz
authors.initials: OH
authors.lastname: Leite
authors.forename: Evandro A
authors.initials: EA
authors.lastname: Rivitti
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D005334:Fever / Q000150:complications* / Q000175:diagnosis; D005500:Follow-Up Studies; D015774:Ganciclovir / Q000008:administration & dosage; D006801:Humans; D016867:Immunocompromised Host; D007150:Immunohistochemistry; D008297:Male; D009894:Opportunistic Infections / Q000150:complications* / Q000175:diagnosis; D010391:Pemphigoid, Bullous / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D011241:Prednisone / Q000008:administration & dosage* / Q000009:adverse effects; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D015774:Ganciclovir; D011241:Prednisone