title: [Effect of topical administration of beclomethasone dipropionate on symptoms of chronic rhinitis].
abstract: The aim of this study was to evaluate the effect of topical administration of corticosteroid beclomethasone dipropionate on common nasal symptoms in moderate allergic and non-allergic hyperreactive eosinophilic rhinitis, and in allergic and non-allergic hyperreactive eosinophilic rhinitis associated with bilateral moderate nasal polyposis. The study was prospective and controlled. During the study 106 patients were examined, out of whom 66 were treated, while 40 had no therapy. Beclomethasone diproprionate nasal spray was administered in the daily dose of 400 micrograms. Patients with isolated rhinitis underwent 3 otorhinolaryngologic examinations during the six-week treatment. Patients with nasal polyposis underwent 4 otorhinolaryngologic examinations during six-month treatment. One-week therapy showed highly significant decrease of the average score of symptoms of isolated rhinitis in relation to basal condition. No further significant change was noted after six-week therapy. Six-week therapy of nasal polyposis exerted significantly reduced score of symptoms in relation to basic condition. During further treatment no significant reduction of symptoms was noted. Follow-up period of all control subgroups showed no significant change of symptom scores. Topical therapy with beclomethasone dipropionate represented a significant medication of the first therapeutic line in moderate isolated eosinophilic rhinitis, as well as in moderate bilateral eosinophilic nasal polyposis.
authors.affiliation: Klinicki centar Srbije, Institut za medicinu rada, Beograd. 08otitis@infosky.net
authors.forename: Dejan
authors.initials: D
authors.lastname: Ursulović
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Janosević
authors.forename: Slobodanka
authors.initials: S
authors.lastname: Janosević
authors.forename: Vojko
authors.initials: V
authors.lastname: Dukić
mesh_terms: D000281:Administration, Intranasal; D000336:Aerosols; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001507:Beclomethasone / Q000008:administration & dosage*; D002908:Chronic Disease; D005938:Glucocorticoids; D006801:Humans; D012220:Rhinitis / Q000188:drug therapy* / Q000503:physiopathology; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy
chemical_list: D000336:Aerosols; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D001507:Beclomethasone
vernacular_title: Efekti topijske primene beklometazon dipropionata na simptome hronicnog rinitisa.