Electrochemical study of oxygen interaction with lapachol and its radical anions.
Cyclovoltammetric studies were performed with lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone], in the absence and presence of oxygen, which aimed to investigate possible oxygen interaction with lapachol and its radical anion. The obtained results clearly indicate the consumption of the semiquinone anion-radicals by oxygen in an EC type reaction, generating the deprotonated form of lapachol and HOO*. The observed generation of reactive oxygen species (ROS) after electron transfer can be related to the mechanism of biological action of lapachol.
Goulart
Marília O F
MO
Departamento de Química-CCEN Campus, Universidade Federal de Alagoas, Tabuleiro dos Martins, Maceio, Brazil. mofg@qui.ufal.br
Falkowski
Piotr
P
Ossowski
Tadeusz
T
Liwo
Adam
A
D002244:Carbon; D004563:Electrochemistry; D004566:Electrodes; D009285:Naphthoquinones / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry*
D009285:Naphthoquinones; D017382:Reactive Oxygen Species; D002244:Carbon; C008252:lapachol; D010100:Oxygen