Candidemia in a tertiary care hospital: epidemiology and factors influencing mortality.
The present study was conducted in order to assess the epidemiology and clinical course of candidemia and to identify the risk factors associated with mortality. A total of 143 episodes of nosocomial candidemia were identified during a 5-year period, and these were included in the study. The majority of candidemic episodes were due to Candida albicans (63, 44%), followed by Candida parapsilosis(32, 22%). The overall mortality was 45%. The following independent prognostic factors for mortality were identified: bacterial sepsis, rapidly fatal illness, chronic obstructive lung disease, presence of a central venous catheter, candidemia due to Candida albicans, and lack of antifungal therapy.
Alonso-Valle
H
H
Division of Preventive Medicine, University of Cantabria, School of Medicine, Santander, Spain.
Acha
O
O
García-Palomo
J D
JD
Fariñas-Alvarez
C
C
Fernández-Mazarrasa
C
C
Fariñas
M C
MC
D000328:Adult; D000368:Aged; D002175:Candida / Q000145:classification* / Q000302:isolation & purification; D002176:Candida albicans / Q000145:classification / Q000302:isolation & purification; D002177:Candidiasis / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D005260:Female; D016469:Fungemia / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors