[Effects of pyrethroids on the glutamate uptake system in synaptic vesicle of rats].
In order to study the effects of cypermethrin and permethrin insecticides on the glutamate uptake of rat brain, brain synaptic vesicles and cypermethrin or permethrin were incubated with 3H-glutamate (37 KBq, 1 mumol/L). The radio activity was detected by a liquid scintillation counter. The results showed that cypermethrin and permethrin in the concentration of 10(-9)-10(-4) mol/L could inhibit the high affinity uptake of glutamate in the synaptosomes of cerebral cortex, hippocampus and striatum in a dose-response manner. Cypermethrin was more powerful than permethrin at the same dose. It was concluded that glutamate uptake inhibition might play a vital role in the neurotoxicity induced by pyrethroid insecticides.
Wu
J
J
Institute of Environmental Toxicology, Tongji Medical University, Wuhan 430030, China. jpwu@dns.njmu.edu.cn
Xia
R
R
Shi
N
N
Liu
Y
Y
D000818:Animals; D001921:Brain / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism*; D007306:Insecticides / Q000633:toxicity; D026023:Permethrin / Q000633:toxicity*; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013572:Synaptic Vesicles / Q000378:metabolism*
D007306:Insecticides; D011722:Pyrethrins; C017160:cypermethrin; D018698:Glutamic Acid; D026023:Permethrin