title: Chronological and replicative lifespan of polyploid Saccharomyces cerevisiae (syn. S. pastorianus).
abstract: Chronological lifespan may be defined as the result of accumulation of irreversible damage to intracellular components during extended stationary phase, compromising cellular integrity and leading to death and autolysis. In contrast, replicative lifespan relates to the number of divisions an individual cell has undertaken before entering a non-replicative state termed senescence, leading to cell death and autolysis. Both forms of lifespan have been considered to represent models of ageing in higher eukaryotes, yet the relation between chronologically and replicatively aged populations has not been investigated. In this study both forms of lifespan have been investigated in Saccharomyces cerevisiae (Syn. S. pastorianus) to establish the relationship between chronological and replicative ageing.
authors.affiliation: School of Biological and Molecular Sciences, Oxford Brookes University, Gipsy Lane, Headington, Oxford OX3 0BP, UK.
authors.forename: Dawn L
authors.initials: DL
authors.lastname: Maskell
authors.forename: Alan I
authors.initials: AI
authors.lastname: Kennedy
authors.forename: Jeff A
authors.initials: JA
authors.lastname: Hodgson
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Smart
mesh_terms: D001463:Barbiturates / Q000378:metabolism; D002453:Cell Cycle / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002499:Centrifugation, Density Gradient; D015169:Colony Count, Microbial; D018613:Microscopy, Confocal; D010640:Phenothiazines / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000254:growth & development* / Q000378:metabolism
chemical_list: D001463:Barbiturates; D010640:Phenothiazines; C019029:oxonol dyes (barbiturate); C060547:methylene violet