[Effect of lysozyme on the growth of murine lymphoma and antineoplastic activity of cyclophosphamide].
It was shown that hen egg-white lysozyme (LM) in the dose 100 mg/kg under the daily intragastral use slightly inhibited tumor grown or did not influence significantly upon it and did not change antitumor activity of cyclophosphamide. When used at mice C57Bl/6J with the transplanted ascitic or solid T-cell lymphoma EL4 (syngeneic system). On model of the same tumors in ascitic form at mice-hybrids (C57Bl/6J x DBA2)F1 (semisingeneic system) LM significantly potentiates antitumor activity of cyclophosphamide, though it had no effect on the rate of tumor growth. Potentiation of the effect of cyclophosphamide revealed itself in more slow development of ascite, increased mean life-span and the overall survival, appearance of completely cured animals. Our clinic-laboratory studies have revealed a sharp deficit of endogenic lysozyme in the blood serum of leukemic patients and extremely low lysozyme content in lavage liquid, from leukemic patients, with pneumonia. These data suggest that LM can be useful as a food additive in the complex treatment of oncological patients for enhancing antineoplastic chemotherapy efficacy.
Shcherbakova
E G
EG
Russian Medical Academy of Prolonged Education, Moscow.
Bukhman
V M
VM
Isakova
E B
EB
Bodiagin
D A
DA
Arkhipova
N A
NA
Rastunova
G A
GA
Vorob'eva
L S
LS
Lipatov
N N
NN
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology*; D008223:Lymphoma / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009113:Muramidase / Q000494:pharmacology*
D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide; D009113:Muramidase
Vliianie lizotsima na rost myshinoĭ limfomy i protivoopukholevuiu aktivnost' tsiklofosfamida.