title: Fatigue performance and cyto-toxicity of low rigidity titanium alloy, Ti-29Nb-13Ta-4.6Zr.
abstract: A beta type titanium alloy, Ti-29Nb-13Ta-4.6Zr, was newly designed and developed for biomedical applications. The new alloy contains non-toxic elements such as Nb, Ta, and Zr. In the present study, phases that appeared in the new alloy through various aging treatments were characterized by hardness tests and microstructural observations in order to identify the phase transformation. Fatigue properties of the new alloy were investigated. Young's modulus and cyto-toxicity of the new alloy were also evaluated. Precipitated phases distribute homogeneously over the whole specimen, and they are alpha phase, a small amount of omega phase, and beta phase when the new alloys are subjected to aging treatment at 673K for 259.2ks after solution treatment at 1063K for 3.6ks. The fatigue strength of the new alloy subjected to aging at 673K for 259.2ks after solution treatment at 1063K for 3.6ks is much better than when subjected to other aging treatments. In this case, the fatigue limit is around 700MPa. Young's modulus of the new alloy is much smaller than that of Ti-6Al-4V ELI. The cyto-toxicity of the new alloy is equivalent to that of pure Ti. Therefore, it is proposed that the new alloy, Ti-29Nb-13Ta-4.6Zr, will be of considerable use in biomedical applications.
authors.affiliation: Department of Production Systems Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi 441-8580, Japan. niinomi@sp-mac4.tutpse.tut.ac.jp
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Niinomi
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects* / Q000737:chemistry* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004548:Elasticity; D019544:Equipment Failure Analysis; D005347:Fibroblasts / Q000187:drug effects*; D006244:Hardness; D006358:Hot Temperature; D008422:Materials Testing; D051379:Mice; D009556:Niobium / Q000009:adverse effects* / Q000737:chemistry* / Q000633:toxicity; D013499:Surface Properties; D013635:Tantalum / Q000009:adverse effects* / Q000737:chemistry* / Q000633:toxicity; D013718:Tensile Strength; D014025:Titanium / Q000009:adverse effects* / Q000737:chemistry* / Q000633:toxicity; D018675:Toxicity Tests; D015040:Zirconium / Q000009:adverse effects* / Q000737:chemistry* / Q000633:toxicity
chemical_list: D001672:Biocompatible Materials; C481486:Ti-29Nb-13Ta-4.6Zr alloy; D009556:Niobium; D013635:Tantalum; D015040:Zirconium; D014025:Titanium