title: How to start prophylaxis.
abstract: A cohort study was performed to assess the efficacy of a gradual introduction to primary prophylaxis by peripheral vein injections. Bleeding symptoms prior to the initiation of prophylaxis and during the time from the start of home treatment were investigated. Forty-seven boys with severe haemophilia, born between 1987 and 2000, were studied. The mean age at the start of prophylaxis was 16 months and the mean age for the boys on home treatment and full prophylaxis was 30 months. Our results show that primary prophylaxis with injections in a peripheral vein is possible in most patients (83%). Even with this early start, 59% of the children had been treated with clotting factor concentrate before prophylaxis was initiated. Seventy-two percent of the boys had no symptoms from the joints or muscles in the time from initiation to full prophylaxis every second (haemophilia A) or third day (haemophilia B). None of the patients developed cerebral bleeding during this period, but one patient had an epidural bleeding as the presenting symptom of haemophilia.
authors.affiliation: Department of Pediatric/Coagulation Disorders, Karolinska Hospital, Stockholm, Sweden. pia.petrini@ks.se
authors.forename: P
authors.initials: P
authors.lastname: Petrini
mesh_terms: D002675:Child, Preschool; D015331:Cohort Studies; D005169:Factor VIII / Q000627:therapeutic use*; D006467:Hemophilia A / Q000517:prevention & control*; D002836:Hemophilia B / Q000517:prevention & control*; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006699:Home Care Services; D006801:Humans; D007223:Infant; D013997:Time Factors
chemical_list: D005169:Factor VIII