Acetaminophen modifies hippocampal synaptic plasticity via a presynaptic 5-HT2 receptor.
Acetaminophen (APAP) has recently been found to target COX-3, a newly identified COX isozyme. We discovered previously that selective COX-2 inhibitors reduce membrane excitability and long-term potentiation (LTP) in the hippocampus. The purpose of this study was to investigate whether APAP had effects on hippocampal LTP. We found that APAP reduced LTP induction and increased the paired-pulse facilitation (PPF). APAP-induced changes in LTP and PPF were blocked by a 5-hydroxytryptamine (serotonin, 5-HT(2/1)) receptor antagonist. The results suggest that APAP-induced modification of synaptic plasticity at hippocampal lateral perforant path-dentate granule cell synapses may be mediated by a presynaptic 5-HT(2) receptor.
Chen
Chu
C
Neuroscience Center of Excellence, School of Medicine, LSU Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, LA 70112, USA. cchen@lsuhsc.edu
Bazan
Nicolas G
NG
D000082:Acetaminophen / Q000494:pharmacology*; D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009473:Neuronal Plasticity / Q000187:drug effects* / Q000502:physiology; D018408:Patch-Clamp Techniques; D017729:Presynaptic Terminals / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D000082:Acetaminophen