title: The cost-effectiveness of beta-radiation therapy for treatment of in-stent restenosis: an analysis at 290-day follow-up.
abstract: OBJECTIVE
  We studied the cost-effectiveness of percutaneous coronary intervention (PCI) plus beta-radiation (Radiotherapy) vs. PCI alone for treating in-stent restenosis.
  
  
  METHODS
  We analyzed medical resource data collected at US sites during the Intimal Hyperplasia Inhibition with beta In-stent Trial (INHIBIT) to compare the incremental costs between Radiotherapy and PCI alone for each repeat target lesion revascularization (TLR) avoided. Costs were assigned for cardiac-related medical services using the Medicare payer perspective.
  
  
  RESULTS
  Radiotherapy increased initial inpatient costs by US$3360 (P<.001). In the Radiotherapy and PCI alone groups, the mean per-patient rates for TLR were 0.13 vs. 0.30 (P=.001), and mean per-patient total costs were US$19,286 vs. US$18,349 (P<.001), respectively. The incremental cost of Radiotherapy relative to PCI alone was US$5512 per TLR avoided, which compares favorably to the observed mean per-patient cost of treating restenosis (US$16,852).
  
  
  CONCLUSIONS
  beta-radiation is a cost-effective adjunct to PCI in treating patients with in-stent restenosis.
authors.affiliation: Covance Health Economics and Outcomes Services, 9801 Washingtonian Boulevard, Ninth Floor, Gaithersburg, MD 20878, USA.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Beusterien
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Plante
authors.forename: Ron
authors.initials: R
authors.lastname: Waksman
authors.forename: Albert E
authors.initials: AE
authors.lastname: Raizner
authors.forename: Marijke
authors.initials: M
authors.lastname: Annis
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Goss
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000191:economics*; D001610:Beta Particles / Q000627:therapeutic use*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000191:economics*; D003324:Coronary Artery Disease / Q000191:economics* / Q000601:surgery*; D003362:Cost-Benefit Analysis; D005260:Female; D006083:Graft Occlusion, Vascular / Q000191:economics* / Q000209:etiology / Q000628:therapy*; D017048:Health Care Costs; D006801:Humans; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000191:economics*; D018714:Radiotherapy, Adjuvant / Q000191:economics; D016032:Randomized Controlled Trials as Topic / Q000191:economics; D012189:Retrospective Studies