[Endothelial dysfunction in obese hypertensive patients].
A total of 28 patients with stage II hypertensive disease (HD) were examined, their age ranging between 32 to 64 years. Of these, 17 subjects were diagnosed as having had alimentary obesity. The control group comprised 11 subjects with normal level of arterial pressure and body mass. Studied in the above patients were blood serum content of nitrogen oxide by determining levels of its stable metabolites NO2- and NO3- anions. HD patients presenting with normal body weight and those with obesity demonstrated significantly lower blood serum levels of anions NO2- and NO3- as compared to healthy subjects. In HD patients, obesity is accompanied by a more significant reduction in blood serum levels of NO2- and NO3-, which fact might be caused by inhibition of nitratereductase.
Lyzohub
V H
VH
Hula
N M
NM
Khomenko
Zh A
ZhA
Dykukha
I S
IS
Kotsiuruba
A V
AV
Bukhanevych
O M
OM
Kosiakova
H V
HV
D000328:Adult; D015992:Body Mass Index; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000097:blood* / Q000378:metabolism; D009573:Nitrites / Q000097:blood; D009765:Obesity / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology
D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide
Dysfunktsiia endoteliiu u khvorykh na hipertonichnu khvorobu iz suputnim ozhyrinniam.