Pyrrolizidine alkaloids from Lithospermum canescens Lehm.
Seven pyrrolizidine alkaloids (PAs) have been isolated from Lithospermum canescens and their structures determined by spectroscopical methods. Besides the known lycopsamine, O7-acetyl-lycopsamine and O7-acetylintermedine four new PAs were found. Their structures are O7-(3-hydroxy-3-methyl-butanoyl)-O9-(+)-trachelanthoyl-heliotridine (= O7-(3-hydroxy-3-methyl-butanoyl)-rinderine = canescine), O7-(3-hydroxy-3-methyl-butanoyl)-O9-(-)-viridifloryl-heliotridine (= O7-(3-hydroxy-3-methyl-butanoyl)-echinatine = canescenine and their O13-acetyl-derivatives (= acetylcanescine; acetylcanescenine).
Wiedenfeld
Helmut
H
Pharmazeutisches Institut der Universität, An der Immenburg 4, D-53121 Bonn, F. R. G. wiedenfeld@uni-bonn.de
Pietrosiuk
Agnieszka
A
Furmanowa
Miroslava
M
Roeder
Erhard
E
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D029684:Lithospermum / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*
D000470:Alkaloids