HBV associated nephrotic syndrome: resolution with oral lamivudine.
A 6 year old boy presenting with a five month history of fever, lethargy, and anorexia, was found to have hepatitis B associated membranous glomerulonephropathy and nephrotic syndrome. After two months treatment with oral lamivudine, his proteinuria cleared and serum albumin and aminotransferases normalised, associated with disappearance of hepatitis B e antigen (HBeAg) and appearance of anti-HBeAg antibodies. After 12 months, without side effects, lamivudine was discontinued. He remains well 11 months off treatment.
Connor
F L
FL
Department of Gastroenterology, Sydney Children's Hospital and University of New South Wales, Randwick, Australia. flconnor@tpgi.com.au
Rosenberg
A R
AR
Kennedy
S E
SE
Bohane
T D
TD
D000284:Administration, Oral; D000956:Antigens, Viral / Q000032:analysis; D002648:Child; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D006509:Hepatitis B / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage*; D008297:Male; D008854:Microscopy, Electron; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage*
D000956:Antigens, Viral; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine