Chemical protection against radiation-induced genetic damage during the period of after-effects of gravity stress.
The protective effect of cystamine (150 mg kg-1) against genetic damage induced by gamma-radiation in germ cells of the CBA line of mice (at doses of 100, 300 and 600 r) was studied. Cystamine reduced the frequency of dominant lethal mutations in sperms, spermatids and spermatocytes. The amount of protection depended on the radiation dose. After cystamine the lethal effect of radiation on the whole organism was reduced 2-3 times. After transverse acceleration (15 g over 10 min) the protective effect of cystamine against dominant lethal mutations induced by radiation (300 r) decreased on the average by 1/3. The action of transverse acceleration alone somewhat reduced the radiosensitivity of germ cells. The administration of the protector and acceleration did not affect the frequency of reciprocal translocations induced by radiation in spermatogonia.
Pomerantseva
M D
MD
USSR Academy of Sciences, Moscow, USSR.
Antipov
V V
VV
Vilkina
G A
GA
Gugushvili
B S
BS
D000054:Acceleration; D000818:Animals; D003538:Cystamine / Q000627:therapeutic use*; D004307:Dose-Response Relationship, Radiation; D004622:Embryo, Mammalian / Q000528:radiation effects; D005260:Female; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009154:Mutation; D011247:Pregnancy; D011270:Pregnancy, Animal; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011835:Radiation Protection; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D013091:Spermatogenesis / Q000528:radiation effects; D013094:Spermatozoa / Q000528:radiation effects*
D011837:Radiation-Protective Agents; D003538:Cystamine