Functional topography of connections linking mirror-symmetric maps in the mouse olfactory bulb.
In rodents, each main olfactory bulb contains two mirror-symmetric glomerular maps, a feature not found in the initial topographic maps of other sensory systems. Targeting tracer injections to identified glomeruli revealed that isofunctional odor columns-translaminar assemblies connected to a given glomerulus-were specifically and reciprocally interconnected through a mutually inhibitory circuit with exquisite topographic specificity. Thus, instead of containing two mirror-symmetric maps, we propose that the olfactory bulb contains a single integrated map in which isofunctional odor columns are connected through an intrabulbar link, analogous to the specific horizontal connections linking iso-orientation columns in primary visual cortex.
Lodovichi
Claudia
C
Howard Hughes Medical Institute, Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Belluscio
Leonardo
L
Katz
Lawrence C
LC
D000818:Animals; D001931:Brain Mapping / Q000379:methods*; D049452:Green Fluorescent Proteins; D008164:Luminescent Proteins / Q000096:biosynthesis / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains; D009433:Neural Inhibition / Q000502:physiology; D009830:Olfactory Bulb / Q000033:anatomy & histology* / Q000166:cytology / Q000502:physiology; D009833:Olfactory Pathways / Q000033:anatomy & histology* / Q000166:cytology / Q000502:physiology; D018034:Olfactory Receptor Neurons / Q000166:cytology / Q000502:physiology; D018035:Receptors, Odorant / Q000096:biosynthesis / Q000235:genetics
D008164:Luminescent Proteins; D018035:Receptors, Odorant; D049452:Green Fluorescent Proteins