title: Neuropsychological outcome in long-term survivors of a childhood extracranial solid tumor who have undergone autologous bone marrow transplantation.
abstract: The purpose of this study was to evaluate neuropsychological and adaptive functioning of children who have undergone bone marrow transplantation (BMT) without previous cranial irradiation. In total, 76 children treated for an extracranial tumor with BMT without total body irradiation (TBI) were evaluated at least 5 years after the end of the treatment.Overall, their performance and skills were in the normal range and their professional and academic outcomes were satisfactory. Nevertheless, we observed a deleterious effect of deafness on verbal IQ associated with the previous administration of cisplatin during conventional chemotherapy. In addition, reading difficulties had arisen. This could be related to absence from kindergarten or primary school during hospitalization. Finally, in the younger subgroup, visual-perceptual skills were found to be more fragile.
authors.affiliation: Pediatrics Department, Institut Gustave Roussy, Villejuif, France.
authors.forename: P
authors.initials: P
authors.lastname: Notteghem
authors.forename: C
authors.initials: C
authors.lastname: Soler
authors.forename: G
authors.initials: G
authors.lastname: Dellatolas
authors.forename: V
authors.initials: V
authors.lastname: Kieffer-Renaux
authors.forename: D
authors.initials: D
authors.lastname: Valteau-Couanet
authors.forename: G
authors.initials: G
authors.lastname: Raimondo
authors.forename: O
authors.initials: O
authors.lastname: Hartmann
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000523:psychology*; D001859:Bone Neoplasms / Q000523:psychology / Q000628:therapy; D002648:Child; D004411:Dyslexia, Acquired; D004522:Educational Status; D018240:Endodermal Sinus Tumor / Q000523:psychology / Q000628:therapy; D005260:Female; D006319:Hearing Loss, Sensorineural; D006801:Humans; D007680:Kidney Neoplasms / Q000523:psychology / Q000628:therapy; D008223:Lymphoma / Q000523:psychology / Q000628:therapy; D008297:Male; D008568:Memory; D009423:Nervous System Neoplasms / Q000523:psychology* / Q000628:therapy*; D009447:Neuroblastoma / Q000523:psychology* / Q000628:therapy*; D009483:Neuropsychological Tests; D012516:Osteosarcoma / Q000523:psychology / Q000628:therapy; D012208:Rhabdomyosarcoma / Q000523:psychology / Q000628:therapy; D012512:Sarcoma, Ewing / Q000523:psychology / Q000628:therapy; D018582:Sick Leave; D014182:Transplantation, Autologous; D009396:Wilms Tumor / Q000523:psychology / Q000628:therapy