title: Primary chemoradiation as definitive treatment for unresectable cancer of the trachea.
abstract: A 64-year-old man was diagnosed with unresectable cancer of the trachea. He was treated definitively with a novel chemoradiation regimen. Cisplatin-based chemotherapy (ChT) was given for two cycles as induction, followed by concurrent administration of this ChT with external beam radiotherapy (RT) (total dose 60 Gy). An unexpected partial tumour response was noted after the induction of ChT alone. Six weeks after finishing ChT/RT, complete response of the lesion was noted on computed tomography imaging. Two years later, the patient was free of disease. Primary chemoradiation appears to be effective in managing locally advanced tracheal cancer.
authors.affiliation: Department of Radiation Oncology, Dana-Farber Cancer Institute,Harvard Medical School, Boston, MA, USA. videtig@ccf.org
authors.forename: Gregory M M
authors.initials: GM
authors.lastname: Videtic
authors.forename: Carolyn
authors.initials: C
authors.lastname: Campbell
authors.forename: Mark D
authors.initials: MD
authors.lastname: Vincent
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D003967:Diarrhea / Q000139:chemically induced; D004334:Drug Administration Schedule; D015251:Epirubicin / Q000008:administration & dosage / Q000009:adverse effects; D004941:Esophagitis / Q000139:chemically induced; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D013902:Radiography, Thoracic; D011879:Radiotherapy Dosage; D014134:Tracheal Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000532:radiotherapy*; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000150:complications / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D015251:Epirubicin; D002945:Cisplatin; D002955:Leucovorin; D005472:Fluorouracil