title: An effective one-pot synthesis of 5-substituted tetronic acids.
abstract: An expeditious one-pot synthesis of 5-substituted tetronic acids from aldehydes and terminal conjugated alkyne as starting materials is described. The entire process embodies two consecutive chemical events: a catalytic domino reaction to build the 1,3-dioxolane scaffolds 5 and a two-step acid-catalyzed trans-acetalization-lactonization reaction to furnish the tetronic acid derivatives 6.
authors.affiliation: Instituto de Productos Naturales y Agrobiología, CSIC, Avda. Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.
authors.forename: David Tejedor
authors.initials: DT
authors.lastname: Aragón
authors.forename: Gloria V
authors.initials: GV
authors.lastname: López
authors.forename: Fernando
authors.initials: F
authors.lastname: García-Tellado
authors.forename: José Juan
authors.initials: JJ
authors.lastname: Marrero-Tellado
authors.forename: Pedro
authors.initials: P
authors.lastname: de Armas
authors.forename: David
authors.initials: D
authors.lastname: Terrero