title: Three cases of advanced seminoma and Down's syndrome: a possible association.
abstract: This is a report of three cases of classic seminoma in Down's syndrome patients treated at our institution. Review of literature shows an observation of increased occurrence of testicular cancer in patients with DS, however, with no definitive association documented. A brief discussion of the possible pathogenesis is presented.
authors.affiliation: Department of Radiation Oncology, Hospital of the University of Pennsylvania, 2 Donner Building, 3400 Spruce Street, Philadelphia, PA 19104, U.S.A.
authors.forename: Diana C
authors.initials: DC
authors.lastname: Hsiung Stripp
authors.forename: David
authors.initials: D
authors.lastname: Vaughn
authors.forename: Keith
authors.initials: K
authors.lastname: Van Arsdalen
authors.forename: Richard
authors.initials: R
authors.lastname: Whittington
mesh_terms: D000328:Adult; D004314:Down Syndrome / Q000150:complications*; D006801:Humans; D008297:Male; D018239:Seminoma / Q000150:complications* / Q000453:epidemiology; D013736:Testicular Neoplasms / Q000150:complications* / Q000453:epidemiology