Effects of cholecystokinin-4 on secretory activity of rat mast cells.
Intraperitoneal injection of cholecystokinin-4 in a dose of 100 mg/kg markedly increased secretory activity of mast cells in the mesentery and subcutaneous fat. These changes developed 5 min after treatment and progressed in time. Over the first 15 min we observed primarily merocrine secretion (granulolysis), while 60 min after cholecystokinin-4 administration apocrine secretion (degranulation) prevailed. In vitro cholecystokinin-4 had no effect on secretory activity of mast cells. Our findings suggest that stimulation of secretory activity of mast cells is determined by psychoemotional stress associated with activation of the sympathoadrenal and hypothalamic-pituitary-adrenal systems.
Smirnova
E A
EA
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University. smelal@pochtamt.ru
Umarova
B A
BA
Kopylova
G N
GN
Goncharova
E L
EL
D000818:Animals; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D051381:Rats; D013315:Stress, Psychological / Q000139:chemically induced / Q000503:physiopathology*; D013758:Tetragastrin / Q000494:pharmacology*
D013758:Tetragastrin