title: Translocation (1;4)(p31;q34) in nonossifying fibroma.
abstract: Nonossifying fibroma is a benign, lytic lesion of fibrous origin most often observed in the metaphyseal region of the long bones in children and adolescents. It is frequently asymptomatic and is often characterized by a history of spontaneous resolution. Herein, we report a clinicohistopathologically typical case of nonossifying fibroma arising in the tibia of an 18-year-old skeletally mature female. Conventional cytogenetic analysis revealed a reciprocal translocation involving bands 1p31 and 4q34 [t(1;4)(p31;q34)]. To the best of our knowledge, this is only the second reported case of a clonally aberrant nonossifying fibroma.
authors.affiliation: Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Marilu
authors.initials: M
authors.lastname: Nelson
authors.forename: Deborah
authors.initials: D
authors.lastname: Perry
authors.forename: Glen
authors.initials: G
authors.lastname: Ginsburg
authors.forename: Warren G
authors.initials: WG
authors.lastname: Sanger
authors.forename: James R
authors.initials: JR
authors.lastname: Neff
authors.forename: Julia A
authors.initials: JA
authors.lastname: Bridge
mesh_terms: D000293:Adolescent; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005260:Female; D005350:Fibroma / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D007717:Knee / Q000473:pathology; D014178:Translocation, Genetic / Q000235:genetics*