title: Lithium carbonate 24-hour extended-release capsule filled with 6 mm tablets.
abstract: A 24-h extended-release multiparticulate capsule containing a dose of 500 mg of lithium carbonate divided into 6 tablets 6 mm in size was produced. In order to achieve an immediate and prolonged drug release profile one uncoated tablet and 5 tablets coated with methacrylic acid/ethyl acrylate copolymer Kollicoat MAE30DP were filled into a capsule. The core of tablets consisted of microcrystalline cellulose, lactose, povidone, macrogol and magnesium stearate.
authors.affiliation: Department of Pharmaceutical Technology, Medical University, Gdansk, Poland.
authors.forename: P
authors.initials: P
authors.lastname: Pietkiewicz
authors.forename: M
authors.initials: M
authors.lastname: Sznitowska
authors.forename: A
authors.initials: A
authors.lastname: Dorosz
authors.forename: J
authors.initials: J
authors.lastname: Lukasiak
mesh_terms: D018692:Antimanic Agents / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations; D016651:Lithium Carbonate / Q000008:administration & dosage* / Q000737:chemistry; D013607:Tablets
chemical_list: D018692:Antimanic Agents; D003692:Delayed-Action Preparations; D013607:Tablets; D016651:Lithium Carbonate