Lambert-Eaton Myasthenic syndrome in a child with an autoimmune phenotype.
We report on a child with a family history of autoimmune defects, who presented at the age of 3(1/2) years with alopecia and Graves disease. He subsequently developed vitiligo and psoriasis. At 9(1/2) years, he developed an autoimmune form of Lambert-Eaton Myasthenic syndrome (LEMS) with a significant elevation of glutamic acid decarboxylase (GAD) autoantibodies. Shortly thereafter he developed chronic urticaria. HLA associations were present for Graves disease, vitiligo, psoriasis, and IgA deficiency. There was also evidence of autoimmunity involving the pancreatic islet cells and gastric parietal cells.
Hoffman
William H
WH
Section of Pediatric Endocrinology, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912, USA. whoffman@mail.mcg.edu
Helman
Sandra W
SW
Sekul
Elizabeth
E
Carroll
James E
JE
Vega
Roger A
RA
D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D002648:Child; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000235:genetics / Q000276:immunology*; D008297:Male
D006680:HLA Antigens