title: Temporal alterations in voltage gated Ca2+ channel immunoreactivities in the gerbil hippocampus following ischemic insults.
abstract: In the present study, temporal changes of voltage-gated Ca(2+) channel (VGCC) immunoreactivities were evaluated in the gerbil hippocampus following ischemia. P/Q-type VGCC immunoreactivity was elevated in the hippocampus in the 3 h post-ischemic group. In the 30 min post-ischemic group, N-type VGCC immunoreactivity began to increase only in the CA1 region. L-type (alpha1C) VGCC immunoreactivity was significantly increased in the 12 h post-ischemic group. L-type (alpha1D) VGCC immunoreactivity began to increase in the CA1 region in the 30 min post-ischemic group and peaked in the 12 h post-ischemic group. These findings suggest that the altered VGCC immunoreactivities following ischemia may play an important role in the ischemic neuronal injury.
authors.affiliation: Department of Anatomy, College of Medicine, Hallym University, Chunchon, Kangwon-Do 200-702, South Korea.
authors.forename: Seung-Kook
authors.initials: SK
authors.lastname: Park
authors.forename: Sung-Jin
authors.initials: SJ
authors.lastname: An
authors.forename: In-Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Jun-Gyo
authors.initials: JG
authors.lastname: Suh
authors.forename: Yang-Seok
authors.initials: YS
authors.lastname: Oh
authors.forename: Moo Ho
authors.initials: MH
authors.lastname: Won
authors.forename: Tae-Cheon
authors.initials: TC
authors.lastname: Kang
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D015220:Calcium Channels / Q000032:analysis / Q000096:biosynthesis*; D005849:Gerbillinae; D006624:Hippocampus / Q000737:chemistry / Q000378:metabolism*; D007120:Immunochemistry; D008297:Male; D013997:Time Factors
chemical_list: D015220:Calcium Channels