title: A new ratiometric fluorescence probe as strong sensor of surface charge of lipid vesicles and micelles.
abstract: We report on the ability of a new fluorescent probe, 4-(2-pyren-1-yl-vinyl) pyridine, 1, to respond to micelles and phospholipid vesicles of different surface charge. The probe gets incorporated into micellar and membranous assemblies and shows a large red-shift in the fluorescence emission maxima especially when the surface charge of the organized media is anionic. The effect on the photo-excitation of the probe is very clear and pronounced as it can be easily visualized. The sample color upon photo-excitation changes from blue to orange/red once the probe experiences negatively charged vesicular or micellar surfaces. These results make the probe molecule useful as a reporter for sensing electrostatic environment in biological membranes and related organized assemblies.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore, India.
authors.forename: Yashveer
authors.initials: Y
authors.lastname: Singh
authors.forename: Akash
authors.initials: A
authors.lastname: Gulyani
authors.forename: Santanu
authors.initials: S
authors.lastname: Bhattacharya
mesh_terms: D000838:Anions; D005456:Fluorescent Dyes / Q000737:chemistry*; D008081:Liposomes; D008567:Membranes, Artificial; D008823:Micelles; D010743:Phospholipids / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D055672:Static Electricity; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: C473869:4-(2-pyren-1-yl-vinyl) pyridine; D000838:Anions; D005456:Fluorescent Dyes; D008081:Liposomes; D008567:Membranes, Artificial; D008823:Micelles; D010743:Phospholipids; D011725:Pyridines; D014753:Vinyl Compounds