title: Effects of 5 years growth hormone treatment in patients with Prader-Willi syndrome.
abstract: BACKGROUND
  Short-term studies showed favorable effects of growth hormone (GH) treatment in patients with Prader-Willi syndrome (PWS).
  
  
  OBJECTIVE
  To evaluate the long-term effects of GH therapy in patients with PWS retrospectively.
  
  
  METHODS
  Effects of GH treatment (0.5 IU/kg/w s.c.) for a period of 1 to 5 years were assessed for 37 Japanese patients with PWS aged 3-(9/12) to 21-(3/12) years. Height and weight were expressed as standard deviation scores (SDSs) of Japanese PWS patients. Height velocity, final height, body mass index (BMI) and Rohrer index were also evaluated.
  
  
  RESULTS
  After 1 year of treatment, the mean height velocity improved significantly from 4.32 to 8.69 cm per year (p < 00001). After 5 years of treatment, mean height SDS increased from -0.99 to +0.88 (p = 0.003). Mean final height of treated patients was 158.0 cm in males and 147.7 cm in females. Mean Rohrer index improved from 182 to 164 (p < 0.0001) after 1 year of treatment and stayed stable thereafter.
  
  
  CONCLUSIONS
  Long-term treatment with GH in patients with PWS improved height velocity, height SDS, final height, and the degree of obesity. These data encourage the long-term use of GH in these patients.
authors.affiliation: Department of Pediatrics, Dokkyo University School of Medicine, Koshigaya Hospital, Saitama, Japan. kaobat@dokkyomed.ac.jp
authors.forename: Kazuo
authors.initials: K
authors.lastname: Obata
authors.forename: Satoru
authors.initials: S
authors.lastname: Sakazume
authors.forename: Atsunori
authors.initials: A
authors.lastname: Yoshino
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Murakami
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Sakuta
mesh_terms: D000293:Adolescent; D001827:Body Height / Q000187:drug effects; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D005260:Female; D006128:Growth / Q000187:drug effects; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D011218:Prader-Willi Syndrome / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D013006:Growth Hormone