Copper-catalyzed anti-stereocontrolled ring opening of oxabicyclic alkenes with grignard reagents.
[reaction: see text] A general copper-catalyzed procedure for the stereoselective ring opening of [2.2.1]-oxabicyclic alkenes with Grignard reagents is described. In the presence of catalytic amounts of CuCl/PPh(3) the reaction occurs with very high or complete anti selectivity in all cases.
Gómez Arrayás
Ramón
R
Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Cabrera
Silvia
S
Carretero
Juan C
JC