title: Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions.
abstract: BACKGROUND
  A number of countries have implemented a policy of universal leukoreduction of their blood supply, but the potential role of leukoreduction in decreasing postoperative mortality and infection is unclear.
  
  
  OBJECTIVE
  To evaluate clinical outcomes following adoption of a national universal prestorage leukoreduction program for blood transfusions.
  
  
  METHODS
  Retrospective before-and-after cohort study conducted from August 1998 to August 2000 in 23 academic and community hospitals throughout Canada, enrolling 14 786 patients who received red blood cell transfusions following cardiac surgery or repair of hip fracture, or who required intensive care following a surgical intervention or multiple trauma.
  
  
  METHODS
  Universal prestorage leukoreduction program introduced by 2 Canadian blood agencies. A total of 6982 patients were enrolled during the control period and 7804 patients were enrolled following prestorage leukoreduction.
  
  
  METHODS
  All-cause in-hospital mortality and serious nosocomial infections (pneumonia, bacteremia, septic shock, all surgical site infections) occurring after first transfusion and at least 2 days after index procedure or intensive care unit admission. Secondary outcomes included rates of posttransfusion fever and antibiotic use.
  
  
  RESULTS
  Unadjusted in-hospital mortality rates were significantly lower following the introduction of leukoreduction compared with the control period (6.19% vs 7.03%, respectively; P =.04). Compared with the control period, the adjusted odds of death following leukoreduction were reduced (odds ratio [OR], 0.87; 95% confidence interval [CI], 0.75-0.99), but serious nosocomial infections did not decrease (adjusted OR, 0.97; 95% CI, 0.87-1.09). The frequency of posttransfusion fevers decreased significantly following leukoreduction (adjusted OR, 0.86; 95% CI, 0.79-0.94), as did antibiotic use (adjusted OR, 0.90; 95% CI, 0.82-0.99).
  
  
  CONCLUSIONS
  A national universal leukoreduction program is potentially associated with decreased mortality as well as decreased fever episodes and antibiotic use after red blood cell transfusion in high-risk patients.
authors.affiliation: University of Ottawa Centre for Transfusion Research, and Clinical Epidemiology Program of the Ottawa Health Research Institute, Ottawa, Ontario, Canada. phebert@ohri.ca
authors.forename: Paul C
authors.initials: PC
authors.lastname: Hébert
authors.forename: Dean
authors.initials: D
authors.lastname: Fergusson
authors.forename: Morris A
authors.initials: MA
authors.lastname: Blajchman
authors.forename: George A
authors.initials: GA
authors.lastname: Wells
authors.forename: Andrew
authors.initials: A
authors.lastname: Kmetic
authors.forename: Doug
authors.initials: D
authors.lastname: Coyle
authors.forename: Nancy
authors.initials: N
authors.lastname: Heddle
authors.forename: Marc
authors.initials: M
authors.lastname: Germain
authors.forename: Mindy
authors.initials: M
authors.lastname: Goldman
authors.forename: Baldwin
authors.initials: B
authors.lastname: Toye
authors.forename: Irwin
authors.initials: I
authors.lastname: Schweitzer
authors.forename: Carl
authors.initials: C
authors.lastname: vanWalraven
authors.forename: Dana
authors.initials: D
authors.lastname: Devine
authors.forename: Graham D
authors.initials: GD
authors.lastname: Sher
mesh_terms: D000328:Adult; D000368:Aged; D001771:Blood Banks / Q000592:standards*; D002170:Canada; D002469:Cell Separation; D003428:Cross Infection / Q000453:epidemiology*; D017707:Erythrocyte Transfusion / Q000379:methods / Q000592:standards*; D005260:Female; D005374:Filtration; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D010043:Outcome and Process Assessment, Health Care; D019106:Postoperative Hemorrhage / Q000628:therapy*; D012189:Retrospective Studies; D000094902:Blood Banking / Q000379:methods