[Ion transporters and cardiovascular diseases: pH control or modulation of intracellular calcium concentration].
The regulation of the intracellular pH is under tight control by several ion transport systems including the sodium-proton exchanger, the sodium-bicarbonate cotransporter and the chlore-bicarbonate anion exchanger. While the activation of the anion exchange induces a cellular acidification, both the sodium-proton exchanger and the sodium-bicarbonate cotransporter are responsible for a protection against acidosis by extruding protons or importing bicarbonate. These transporters are transmembrane proteins whose activity is regulated by several mechanisms including phosphorylation, calcium binding and which are involved in several pathophysiologic processes such as ischemia, hypertrophy and arrhythmias. Recent studies suggest that the activation of these transporters during various diseases induces an increase in intracellular calcium concentration. Therefore, inhibiting these transporters could represent novel therapeutic strategies for the treatment of cardiovascular diseases.
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Laboratoire de physiopathologie et pharmacologie cardiovasculaires expérimentales, IFR 100, facultés de médecine et pharmacie, 7, boulevard Jeanne-d'Arc, BP 87900, 21079 Dijon, France. antoine.bril@wanadoo.fr
D017920:Antiporters / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007424:Intracellular Fluid / Q000378:metabolism*; D017136:Ion Transport / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D027982:Sodium-Bicarbonate Symporters / Q000378:metabolism; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism
D017920:Antiporters; D027982:Sodium-Bicarbonate Symporters; D017923:Sodium-Hydrogen Exchangers; D002118:Calcium
Transporteurs ioniques dans les pathologies cardiovasculaires: contrôle du pH ou régulation de la concentration calcique intracellulaire.