title: Apolipoprotein E in schizophrenia: a French association study and meta-analysis.
abstract: Schizophrenic disorders are complex genetic disorders that may involve multiple genes of small effect. Apolipoprotein E (ApoE) gene variants are associated with alterations in brain function and an increased risk of Alzheimer's disease (AD). However, conflicting results have been reported in schizophrenia. We compared the ApoE genotypes of 114 French Caucasian schizophrenic patients and 91 normal controls. No differences in ApoE allele or genotype frequencies were observed between the two groups. However, we observed a possible association between male schizophrenic patients and the ApoE epsilon 2 epsilon 3 genotype. In addition, a meta-analysis of all published case-control studies on ApoE and schizophrenia did not support a major role for ApoE gene variants in schizophrenia as a whole. However, ApoE may be associated with particular forms of schizophrenia.
authors.affiliation: Service de Psychiatrie Adulte, Hôpital Albert Chenevier, Créteil, France. schurhof@ext.jussieu.fr
authors.forename: Franck
authors.initials: F
authors.lastname: Schürhoff
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Krebs
authors.forename: Andrei
authors.initials: A
authors.lastname: Szöke
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Loze
authors.forename: Céline
authors.initials: C
authors.lastname: Goldberger
authors.forename: Valérie
authors.initials: V
authors.lastname: Quignon
authors.forename: Jean
authors.initials: J
authors.lastname: Tignol
authors.forename: Frédéric
authors.initials: F
authors.lastname: Rouillon
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Laplanche
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
mesh_terms: D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005602:France; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E