title: Hypoglycaemic effect of defatted seeds and water soluble fibre from the seeds of Syzygium cumini (Linn.) skeels in alloxan diabetic rats.
abstract: The effect of feeding orally along with diet of different fractions obtained from the seeds of S. cumini was tried on fasting blood glucose and glucose tolerance in normal and alloxan diabetic rats. The quantitative determination showed that S. cumini seeds contained 40% of water soluble gummy fibre and 15% of water insoluble neutral detergent fibre (NDF). This study demonstrated that feeding for 21 days of the diets containing 15% powdered unextracted (intact) seeds containing water soluble gummy fibre, 15% powdered defatted seeds from which lipid and saponins were removed only and 6% water soluble gummy fibre isolated from S. cumini seeds significantly lowered blood glucose levels and improved oral glucose tolerance whereas feeding of the diets containing 15% powdered degummed S. cumini seeds from which water soluble gummy fibre was removed but which contained neutral detergent fibre (NDF) and 2.25% water insoluble neutral detergent fibre (NDF) isolated from S. cumini seeds neither lowered blood glucose levels nor improved oral glucose tolerance in both normal and diabetic rats. These observations indicate that the hypoglycaemic effect of S. cumini seeds was due to water soluble gummy fibre and also that water insoluble neutral detergent fibre (NDF) and other constituents of the seeds had no significant hypoglycaemic effects.
authors.affiliation: Department of Biochemistry, LIT Premises, Nagpur University, Amravati Road, Nagpur 440010, India.
authors.forename: Madhuri
authors.initials: M
authors.lastname: Pandey
authors.forename: Aqueel
authors.initials: A
authors.lastname: Khan
mesh_terms: D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004043:Dietary Fiber / Q000008:administration & dosage*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*; D027842:Syzygium / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D004043:Dietary Fiber; D007004:Hypoglycemic Agents; D000496:Alloxan