Dual-kidney transplants: long-term results.
BACKGROUND
Dual-kidney transplantation, where two usually aged adult kidneys are placed into an adult recipient, is one way to help alleviate the continuing disparity between the number of patients on the kidney transplant waiting list and those who receive kidney transplants each year. The Dual Kidney Registry was developed to analyze donor and recipient data and outcomes at several centers.


METHODS
Two hundred eighty-seven patients who have undergone transplantation since 1994 have been entered into the relational database. The patients were followed yearly after initial entry into the database.


RESULTS
The mean donor age was 58+/-13 years and the mean terminal creatinine clearance was 77+/-40 mL/min. The mean glomerular sclerosis on procurement biopsy was 16+/-13%. Delayed graft function (DGF), defined as dialysis in the first 7 days after transplantation, was a predictor of poor outcome, and increased cold storage time was a predictor of DGF. The overall incidence of DGF was 27%. In recipients with prompt graft function (PGF), the mean cold storage time was 22+/-9 hr versus 29+/-10 hr in recipients with DGF (P<0.001). The overall 1- and 5-year graft survival was 86% and 69%, respectively. The 1- and 5-year graft survival rates were significantly better in recipients with PGF (90% and 74%) versus DGF (79% and 54%) (P<0.002).


CONCLUSIONS
Cold storage time and DGF have a significant impact on the 1- and 5-year graft survival in recipients of dual-kidney transplants. The 5-year graft survival in recipients of dual-kidney transplants is excellent.
Alfrey
Edward J
EJ
Department of Surgery, Penn State University, Hershey, PA 17033, USA. ejalfrey@ psu.edu.
Boissy
Adrienne R
AR
Lerner
Susan M
SM
D000368:Aged; D003404:Creatinine / Q000097:blood; D015925:Cryopreservation; D016208:Databases, Factual; D006085:Graft Survival; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007674:Kidney Diseases / Q000209:etiology / Q000503:physiopathology; D016030:Kidney Transplantation / Q000379:methods*; D008137:Longitudinal Studies; D008875:Middle Aged; D009926:Organ Preservation / Q000009:adverse effects; D011379:Prognosis; D006435:Renal Dialysis; D013997:Time Factors; D016896:Treatment Outcome
D003404:Creatinine