Hepatitis B virus-mediated changes of apolipoprotein mRNA abundance in cultured hepatoma cells.
An inverse correlation between hepatitis B virus (HBV) and steady-state levels of apolipoprotein AI and CIII mRNAs was observed in two hepatoma cell lines. Analysis of a third line containing an inducible viral genome implicated viral pregenomic RNA in apolipoprotein mRNA reduction. We conclude that HBV alters infected cells despite the absence of overt cytopathogenicity.
Norton
Pamela A
PA
Jefferson Center for Biomedical Research and Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Doylestown, Pennsylvania, USA. pamela.norton@mail.tju.edu
Gong
Qiaoke
Q
Mehta
Anand S
AS
Lu
Xuanyong
X
Block
Timothy M
TM
D016632:Apolipoprotein A-I / Q000235:genetics / Q000378:metabolism*; D001056:Apolipoproteins C / Q000235:genetics / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular; D006515:Hepatitis B virus / Q000472:pathogenicity*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D014407:Tumor Cells, Cultured
D016632:Apolipoprotein A-I; D001056:Apolipoproteins C; D012333:RNA, Messenger; D012367:RNA, Viral