title: [Analysis of sperm chromosomes in infertile males with teratozoospermia].
abstract: OBJECTIVE
  The aim of the study was to examine sperm chromosomes from infertile males with teratozoospermia.
  
  
  METHODS
  Basic research study
  
  
  METHODS
  Spermatozoa were obtained from infertile males with teratozoospermia. Intracytoplasmic sperm injection was used to inject human spermatozoa into mouse oocytes in order to examine sperm chromosomes.
  
  
  RESULTS
  Chromosomes of spermatozoa obtained from 6 infertile teratozoospermic and 1 fertile normozoospermic males were investigated. The mean frequency of structural chromosome aberrations in amorphous, motile spermatozoa was similar to that of morphologically normal sperm (9 vs. 7.7%). The structural aberrations found in amorphous, immotile spermatozoa reached 93% and revealed severity was significant.
  
  
  CONCLUSIONS
  Teratozoospermia per se did not increase the frequency of structural chromosome aberrations in sperm. Severe chromosomal damage was revealed when immotile spermatozoa were injected into oocytes by ICSI.
authors.affiliation: Zespołu Biologii Rozrodu, Zakładu Genetyki Człowieka PAN.
authors.forename: Monika A
authors.initials: MA
authors.lastname: Szczygieł
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kusakabe
authors.forename: Ewa
authors.initials: E
authors.lastname: Wiland
authors.forename: Maciej
authors.initials: M
authors.lastname: Kurpisz
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000648:ultrastructure*
vernacular_title: Analiza chromosomów plemników od pacjentów z teratozoospermia.