title: No stirring necessary: parallel carbonylation of aryl halides with CO and various alcohols under pressure.
abstract: The parallel carbonylation of aryl halides with 6-25 bar of CO in 1-mL vials in a standard autoclave was investigated. 4-Bromoacetophenone and 2-chloropyridine were used as model substrates with 102 different O-nucleophiles (primary and secondary alcohols, phenols). No inertization during the loading was necessary. Fifty esters (43 new, yield up to 60%) were isolated and characterized. Ether, ester, ketone, and sometimes even olefin functions were usually tolerated. The new method is suitable for screening and small scale products synthesis.
authors.affiliation: Solvias AG, R-1055.6, CH-4002 Basel, Switzerland.
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Blaser
authors.forename: Martin
authors.initials: M
authors.lastname: Diggelmann
authors.forename: Hans
authors.initials: H
authors.lastname: Meier
authors.forename: Frédéric
authors.initials: F
authors.lastname: Naud
authors.forename: Elke
authors.initials: E
authors.lastname: Scheppach
authors.forename: Anita
authors.initials: A
authors.lastname: Schnyder
authors.forename: Martin
authors.initials: M
authors.lastname: Studer