title: Expression of cyclooxygenase-1 and -2 is limited to the nasal glands in the guinea pig nasal cavity.
abstract: OBJECTIVE
  To clarify the localization of cyclooxygenase (COX)-1 and -2 in the nasal cavity of guinea pigs and ascertain their physiological roles.
  
  
  METHODS
  The distribution of the enzymes was investigated using immunohistochemistry.
  
  
  RESULTS
  Immunoreactivities for COX-1 and -2 were limited to the nasal glands, and no expression was noted in the surrounding vascular endothelial cells, olfactory glands, respiratory epithelium, olfactory epithelium, submucosal tissue or nerves. To confirm the specificity of the reaction, the kidneys of the same animals were prepared as positive controls. The results demonstrated localization of COX-1 and -2 in uriniferous tubules.
  
  
  CONCLUSIONS
  Our findings suggest that COX is involved in the secretion of nasal discharge from the nasal glands and that prostaglandins in the nasal discharge are probably secreted directly from the nasal glands.
authors.affiliation: Department of Otolaryngology, Tokyo Medical and Dental University, Graduate School, Tokyo, Japan. t_yoshi@mva.biglobe.ne.jp
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Takiguchi
authors.forename: Hiro-Oki
authors.initials: HO
authors.lastname: Okamura
authors.forename: Ken
authors.initials: K
authors.lastname: Kitamura
mesh_terms: D000818:Animals; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D005260:Female; D006168:Guinea Pigs; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000032:analysis / Q000378:metabolism*; D023421:Models, Animal; D009296:Nasal Cavity / Q000201:enzymology* / Q000473:pathology*; D009297:Nasal Mucosa / Q000201:enzymology / Q000473:pathology; D009924:Organ Culture Techniques; D011451:Prostaglandin-Endoperoxide Synthases / Q000032:analysis / Q000378:metabolism*; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D007527:Isoenzymes; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases