Comparative crossover controlled study using polysulphone and vitamin E coated dialyzers.
OBJECTIVE
There is relatively little clinical experience reported on the use of the vitamin E coated dialyzer (CL-EE12, Terumo). This study compares its efficacy and intradialytic symptoms with a polysulphone dialyzer in 2 groups of patients in a controlled crossover trial design.


METHODS
This study was carried out at the Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia, during the time period January to March 2002. In group A, 34 patients were dialyzed for 4 weeks with vitamin E dialyzer then switched over to Fresenius 60 (F60) for 4 weeks. In group B, 41 patients were dialyzed with F60 for 4 weeks then switched to vitamin E coated dilayzers for 4 weeks. The following parameters were measured weekly, hemoglobin level, urea reduction ratio (URR), urea clearance ratio (Kt/V), pre and post dialysis diastolic blood pressure (DBP) and systolic blood pressure (SBP), interdialytic weight gain. The patients were observed for interdialytic hypotension or symptoms.


RESULTS
No significant findings were found in any of the parameters except more dialyzer clotting was observed with vitamin E dialyzer than in F60 dialyzers (1.6% of dialysis sessions versus 0.1% P<0.03). The interdialytic weight gain tended to be less in the vitamin E group but did not reach statistically significant difference. The Kt/V and URR were slightly higher when using the vitamin E dialyzer only in the second and third weeks. hypotensive episodes (P<.007) less leg cramp (P<.31) and less itching (P<.02) in the vitamin E coated treated group within group B.


CONCLUSIONS
There were only minor differences noted between the 2 dialyzers in the parameters measured.
Al-Jondeby
Mohamed S
MS
Department Nephrology, Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia.
Cabaguing
Iolani T
IT
Pajarillo
Amelita A
AA
Hawas
Fahd A
FA
Mousa
Dujanah H
DH
Al-Sulaiman
Mohamed H
MH
Shaheen
Faissal A
FA
Al-Khader
Abdulla A
AA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D020099:Coated Materials, Biocompatible; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011108:Polymers; D006435:Renal Dialysis; D013450:Sulfones; D014810:Vitamin E; D015430:Weight Gain
D020099:Coated Materials, Biocompatible; D011108:Polymers; D013450:Sulfones; D014810:Vitamin E; C017662:polysulfone P 1700