A microdialysis technique for continuous subcutaneous glucose monitoring in diabetic patients (part 2).
The aim of this study was to evaluate the reproducibility, the accuracy and the reliability of a continuous subcutaneous glucose measuring system. The GlucoDay system (A. Menarini I.F.R. S.r.l.-Florence, Italy) is a portable instrument provided with a micro-pump and a biosensor, coupled to a microdialysis system (see part 1). This instrument has demonstrated high reliability coupled with a low degree of invasivity. The profiles of glucose monitoring allow to achieve an excellent knowledge of the real variation of glucose in diabetic patients. The reproducibility study showed a bias lower than 10% between instruments. The accuracy study showed a difference from the reference method lower than 15%.
Varalli
M
M
Research and Development Department, A. Menarini Industrie Farmaceutiche Riunite S.r.l., Via Sette Santi, 3-50131, Florence, Italy.
Marelli
G
G
Maran
A
A
Bistoni
S
S
Luzzana
M
M
Cremonesi
P
P
Caramenti
G
G
Valgimigli
F
F
Poscia
Alessandro
A
D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D001786:Blood Glucose / Q000032:analysis; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D003920:Diabetes Mellitus / Q000097:blood*; D006801:Humans; D008297:Male; D017551:Microdialysis / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D001786:Blood Glucose