title: Preparation and drug release behaviors of nimodipine-loaded poly(caprolactone)-poly(ethylene oxide)-polylactide amphiphilic copolymer nanoparticles.
abstract: Amphiphilic block copolymers, poly(caprolactone)-poly(ethylene glycol)-poly(lactide) (PCELA), were synthesized by ring opening polymerization of caprolactone and lactide initiated with the hydroxyl groups of poly(ethylene glycol) (PEG). These copolymers could form micelle-like nanoparticles due to their amphiphilic characteristic. From the observation of transmission electron microscopy (TEM), the nanoparticles exhibited a regular spherical shape with core-shell structure. The critical micelle concentrations (CMC) of these nanoparticles in water were decreased as molecular weight of PEG decreased. The particle sizes obtained by dynamic light scattering of these nanoparticles were in the range of 100-200 nm, and increased as the hydrophobic property of the nanoparticles increased. Nimodipine as a model drug was loaded in these nanoparticles to investigate the drug release behavior. It was found that the chemical composition of the nanoparticles was a key factor in controlling nanoparticle size, nanoparticle yields, drug-entrapment efficiency, and drug release behavior. When the PEG content is about 2% (wt), the release profile of PCELA nanoparticles appeared to follow zero-order kinetics.
authors.affiliation: Department of Polymer Science and Engineering, Nanjing University, Nanjing, 210093, P R, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Hu
authors.forename: Xiqun
authors.initials: X
authors.lastname: Jiang
authors.forename: Yin
authors.initials: Y
authors.lastname: Ding
authors.forename: Leyang
authors.initials: L
authors.lastname: Zhang
authors.forename: Changzheng
authors.initials: C
authors.lastname: Yang
authors.forename: Junfeng
authors.initials: J
authors.lastname: Zhang
authors.forename: Jiangning
authors.initials: J
authors.lastname: Chen
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Yang
mesh_terms: D020341:Absorbable Implants; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry*; D004058:Diffusion; D004343:Drug Implants / Q000138:chemical synthesis / Q000737:chemistry*; D005027:Ethylene Oxide; D007783:Lactones; D008422:Materials Testing; D008863:Microspheres; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D009553:Nimodipine / Q000008:administration & dosage* / Q000737:chemistry*; D010316:Particle Size; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D020099:Coated Materials, Biocompatible; D004343:Drug Implants; D007783:Lactones; C400421:PLC(20)-b-PEO(44); D011091:Polyesters; D011108:Polymers; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; D009553:Nimodipine; D005027:Ethylene Oxide