Does the intrinsic instability of aneuploid genomes have a causal role in cancer?
The role of aneuploidy in carcinogenesis has long been debated. We argue here that aneuploid genomes are naturally more susceptible to the types of chromosome rearrangement and epigenetic aberration that are found typically in tumor cells. In some cases, the formation of an aneuploid genome might be the initiating step in neoplastic conversion.
Matzke
Marjori A
MA
Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, A-5020 Salzburg, Austria. mmatzke@imb.oeaw.ac.at
Mette
M Florian
MF
Kanno
Tatsuo
T
Matzke
Antonius J M
AJ
D000782:Aneuploidy; D000818:Animals; D002471:Cell Transformation, Neoplastic; D002869:Chromosome Aberrations; D019175:DNA Methylation; D015321:Gene Rearrangement; D016678:Genome; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D011995:Recombination, Genetic