[Autonomic control of cardiac function involves modulation of hyperpolarization activated channels in vitro].
We examined the role of hyperpolarization-activated currents (Ih) in heart rate regulation in mongrel white rats. The ZD 7288 blocking agent decreased the heart rate. Vagus stimulation in bradycardia also decreased the heart rate and was dose-depended. Vagotomy following the ZD 7288 administration induced different dose-dependent changes in heart activity. The index figures of the heart activity following beta-AR isoproterenol administration depended on the level of hyperpolarization-activated currents. The data suggest existence of a possible modulating effect of the ANS on the hyperpolarization-activated activity of the channels.
Ziiatdinova
N I
NI
Kazan State Medical University, 420012, Kazan, 49 Butlerov St., Russia.
Zefirov
A L
AL
Sitdikov
F G
FG
Zefirov
T L
TL
D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D001919:Bradycardia / Q000503:physiopathology; D002317:Cardiovascular Agents / Q000494:pharmacology; D054815:Cyclic Nucleotide-Gated Cation Channels; D004305:Dose-Response Relationship, Drug; D004553:Electric Conductivity; D004558:Electric Stimulation; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects / Q000294:innervation* / Q000502:physiology; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels / Q000037:antagonists & inhibitors*; D015221:Potassium Channels; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology
D002317:Cardiovascular Agents; D054815:Cyclic Nucleotide-Gated Cation Channels; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels; D015221:Potassium Channels; D011743:Pyrimidines; C082246:ICI D2788
Vegetativnyĭ kontrol' serdechnoĭ deiatel'nosti vkliuchaet moduliatsiiu kanalov, aktiviryemykh pri giperpoliarizatsii in vitro.