Primary pulmonary pleomorphic adenoma. An immunohistochemical study and review of the literature.
Primary pleomorphic adenoma of the lung is an uncommon condition. We present a case of primary pulmonary pleomorphic adenoma and its immunohistologic features. The presence of immunoreactivity to both anticytokeratin and antivimentin antibodies for its epithelial components is suggestive of a primary pulmonary lesion. Its high proliferation index and its immunoreactivity to tumor regulatory gene p16(INK4A) are features that, to our knowledge, have not been reported previously. They may have a role in the frequent recurrence of these tumors many years after their apparently complete excision. Detailed genetic investigation and long-term follow-up of this rare tumor will aid in the characterization of its biologic profile.
Ang
Keng Leong
KL
Department of Cardiothoracic Surgery, Harefield Hospital, United Kingdom.
Dhannapuneni
Venkata Ramana
VR
Morgan
William Ellis
WE
Soomro
Irshad Nabi
IN
D008949:Adenoma, Pleomorphic / Q000737:chemistry / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D007633:Keratins / Q000032:analysis / Q000276:immunology; D008175:Lung Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D008875:Middle Aged; D014746:Vimentin / Q000032:analysis / Q000276:immunology
D014746:Vimentin; D007633:Keratins