Relationship between advanced glycoxidation end products, inflammatory markers/acute-phase reactants, and some autoantibodies in chronic hemodialysis patients.
Uremia and dialysis treatment are associated with uncorrected oxidative and carbonyl stress and microinflammation. Elevation of both oxidative/carbonyl stress end products (advanced oxidation protein products (AOPP), advanced glycation end products (AGEs), and advanced lipoperoxidation end products (ALEs), autoantibodies against modified biological structures, and acute-phase reactants (e.g., C-reactive protein [CRP], fibrinogen) seems to take part in the development of various complications, among them accelerated atherosclerosis. These pathogenic mechanisms are supposed to act synergically; nevertheless, oxidative stress shows a closer relationship to inflammation and acute-phase reaction than advanced glycation. Its end product, AOPP, could, thus, represent a biochemical marker of specific importance.
Kalousová
Marta
M
Institute of Medical Biochemistry, 1st Department of Medicine, Division of Nephrology, and 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. mkalousova@hotmail.com
Zima
Tomás
T
Tesar
Vladimír
V
Sulková
Sylvie
S
Fialová
Lenka
L
D000209:Acute-Phase Proteins / Q000276:immunology / Q000378:metabolism*; D001323:Autoantibodies / Q000276:immunology*; D015415:Biomarkers; D017127:Glycation End Products, Advanced / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000378:metabolism* / Q000628:therapy; D006435:Renal Dialysis
D000209:Acute-Phase Proteins; D001323:Autoantibodies; D015415:Biomarkers; D017127:Glycation End Products, Advanced