title: Adherence to highly active antiretroviral therapy is better in patients receiving non-nucleoside reverse transcriptase inhibitor-containing regimens than in those receiving protease inhibitor-containing regimens.
abstract: The difference between adherence to non- nucleoside reverse transcriptase inhibitor (NNRTI) and protease inhibitor (PI)-based regimens was investigated. Better adherence was found in NNRTI-treated patients, especially when efavirenz was included in the regimen, compared with single PI-treated patients and in those with CD4 cell counts less than 200 x 10(6)/l. By contrast, younger age, self-report of active drug use, fatigue or vomiting negatively affected adherence. Self-reported sexual dysfunction was significantly associated with non-adherence only in PI-treated individuals.
authors.affiliation: Istituto Nazionale per le Malattie Infettive, L. Spallanzani IRCCS, Rome, Italy.
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Trotta
authors.forename: Adriana
authors.initials: A
authors.lastname: Ammassari
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cozzi-Lepri
authors.forename: Mauro
authors.initials: M
authors.lastname: Zaccarelli
authors.forename: Francesco
authors.initials: F
authors.lastname: Castelli
authors.forename: Pasquale
authors.initials: P
authors.lastname: Narciso
authors.forename: Sara
authors.initials: S
authors.lastname: Melzi
authors.forename: Andrea
authors.initials: A
authors.lastname: De Luca
authors.forename: Antonella D'Arminio
authors.initials: AD
authors.lastname: Monforte
authors.forename: Andrea
authors.initials: A
authors.lastname: Antinori
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D005221:Fatigue / Q000139:chemically induced; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D012044:Regression Analysis; D012307:Risk Factors; D012735:Sexual Dysfunction, Physiological / Q000139:chemically induced; D019966:Substance-Related Disorders / Q000150:complications; D011795:Surveys and Questionnaires; D014839:Vomiting / Q000139:chemically induced
chemical_list: D017320:HIV Protease Inhibitors; D054303:HIV Reverse Transcriptase