title: Effects of methylprednisolone pulses on renal function of guinea pigs.
abstract: Methylprednisolone produced a dose dependant significant increase in glomerular filtration rate, a significant decrease in sodium excretion, and a significant increase in urinary alkaline phosphatase activity in guinea pigs. The renal histology in groups with 4, 5 and 6 doses revealed mild degenerative changes in the tubular epithelial cells. The results suggest the beneficial effects of methylprednisolone pulse therapy on renal function mainly by increasing glomerular filtration rate with only minimal side effects.
authors.affiliation: Second Department of Pediatrics, University of Athens, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Gourgiotis
authors.forename: Lydia
authors.initials: L
authors.lastname: Nakopoulou
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Kavazarakis
authors.forename: Maria
authors.initials: M
authors.lastname: Moustaki
authors.forename: Marios P
authors.initials: MP
authors.lastname: Zeis
authors.forename: Theano
authors.initials: T
authors.lastname: Tsoukatou
authors.forename: Petros M
authors.initials: PM
authors.lastname: Zeis
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007677:Kidney Function Tests; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D008775:Methylprednisolone