The influence of amitraz on biochemical parameters in mice.
In this study, the effect of amitraz on biochemical parameters of mice was studied. Mice were given amitraz by gavage at 15 or 45 mg/kg body weight. Since the drug was diluted with dimethylsulphoxide (DMSO), it was administered to another experimental animal group in order to determine its own effects on biochemical parameters. Following drug administration, 48 hours passed to let hepatic lesions develop and after that 1 mL of blood was taken from each mouse. They were killed by ether euthanasia for histopathological examination. The result of the analyses revealed that amitraz had no effect on serum glucose concentration, whereas DMSO led to a significant decrease in blood sugar concentration. Increase in urea, phosphorous, aspartate transaminase and alanine amino transferase values were observed only in the group given 45 mg/kg body weight amitraz. A decrease in creatinine and alkaline phosphatase concentrations was observed in all groups. No differences were observed in serum calcium and bilirubin concentrations. No pathological changes were detected in the kidneys and livers. It was concluded that, even in asymptomatic amitraz toxicity cases, adverse effects on kidney and liver functions were likely to develop.
Filazi
Ayhan
A
Ankara University, Faculty of Veterinary Medicine, 06110 Diskapi, Ankara, Turkey. filazi@veterinary.ankara.edu.tr
Sireli
Meltem
M
Kalkan
Faruk
F
D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014052:Toluidines / Q000008:administration & dosage / Q000633:toxicity*; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D007306:Insecticides; D014052:Toluidines; C014983:amitraz; D014508:Urea; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase