Phospholipid composition of granulation and fibrous tissues in rats after local application of melatonin.
We studied the effect of melatonin applied locally in doses of 1.5 and 15 mg/ml on the phospholipid composition of granulation and fibrous tissues in rats at various stages of regeneration. Melatonin (especially in a dose of 1.5 mg/ml) increased the total phospholipid content on day 8 of regeneration, which was primarily related to accumulation of ethanolamine- and serine-containing fractions. Melatonin in a dose of 15 mg/ml increased the concentration of choline-containing fractions on day 5 of regeneration.
Gribanov
G A
GA
Department of Biochemistry and Biotechnology, Tver' State University.
Guseva
V V
VV
Volodina
T V
TV
Kozel'tsev
V L
VL
Bykov
V A
VA
D000287:Administration, Topical; D000818:Animals; D003238:Connective Tissue / Q000187:drug effects / Q000378:metabolism*; D006097:Granulation Tissue / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008550:Melatonin / Q000008:administration & dosage* / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
D010743:Phospholipids; D008550:Melatonin