title: From knowing to controlling: a path from genomics to drugs using small molecule probes.
abstract: The National Cancer Institute Initiative in Chemical Genetics is designed to encourage the development of small molecular probes. The probes are useful for activating or inactivating protein functions, thereby providing resources that help discern the functions of gene products in normal and disease cells, as well as in tissues. This initiative includes "ChemBank," a suite of informatics tools and databases aimed at promoting the development and use of chemical genetics by scientists worldwide. The information generated with such tools should provide a critical link from genomic discovery to drug development.
authors.affiliation: Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Bethesda, MD 20892, USA. RLS@nih.gov
authors.forename: Robert L
authors.initials: RL
authors.lastname: Strausberg
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Schreiber
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D002986:Clinical Trials as Topic; D020650:Combinatorial Chemistry Techniques; D019295:Computational Biology; D016208:Databases, Factual; D015195:Drug Design; D023281:Genomics; D006801:Humans; D015336:Molecular Probe Techniques; D015335:Molecular Probes; D009316:National Institutes of Health (U.S.); D004364:Pharmaceutical Preparations; D011506:Proteins / Q000502:physiology*; D013678:Technology, Pharmaceutical; D014481:United States
chemical_list: D015335:Molecular Probes; D004364:Pharmaceutical Preparations; D011506:Proteins