Suppression of natural killer cells after acute intoxication with alcohols and cholinotropic preparations and their reactivation with T-activin.
Acute poisoning with alcohols and cholinotropic preparations carboxyphosphamide and atropine (0.8 LD(50)) was modeled on male outbred mice weighing 18-24 g. The decrease in activity of natural killer cells was most pronounced after injection of atropine, but insignificant after treatment with ethanol. The inhibitory effect of ethylene glycol, methanol, and methanol on functional activity of natural killer cells in vitro directly depended on their concentration. The effects of alcohols in equimolar concentrations of 10, 100, and 500 mM were similar. Therefore, immunotoxicity of alcohols was associated with the action of their metabolites. The ability of products formed after biotransformation of ethylene glycol, methanol, and ethanol in equimolar concentrations to cause damage to natural killer cells decreased in the following order: glyoxylic acid>formic acid>acetaldehyde>glycolaldehyde>glycolic acid. T-Activin injected subcutaneously in doses of 2.5 and 5.0 microg/kg for 3 days normalized activity of natural killer cells suppressed after acute poisoning with alcohols and cholinotropic preparations.
Zabrodskii
P F
PF
Saratov State Medical University. pz@renet.com.ru
Kirichuk
V F
VF
Germanchuk
V G
VG
Nodel'
M L
ML
Rush
M L
ML
Molotkov
A O
AO
Mal'tseva
G M
GM
Osipov
O V
OV
D000208:Acute Disease; D000435:Alcoholic Intoxication / Q000276:immunology*; D000818:Animals; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D017646:Organosilicon Compounds / Q000506:poisoning*; D010455:Peptides / Q000494:pharmacology*; D013949:Thymus Extracts / Q000494:pharmacology*
D017646:Organosilicon Compounds; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin