Hodgkin's disease in the setting of human immunodeficiency virus infection.
The incidence of Hodgkin's disease appears to progressively increase in human immunodeficiency virus (HIV)-infected patients, with the relative risk of developing this malignancy rising from the early phase to the advanced stage of HIV disease. Clinical and pathological features of Hodgkin's lymphoma in HIV-positive subjects differ from those of the general population, showing a higher frequency of unfavourable histological subtypes, advanced stage with frequent extranodal involvement at initial diagnosis, and a poor therapeutic outcome. The optimal therapeutic strategy is still controversial, and median overall survival is short, ranging from 12 to 18 months. In this report cases of Hodgkin's disease are described among over 1,000 HIV-infected patients referring to a tertiary care centre during a 6 y study period.
Calza
Leonardo
L
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, 'Alma Mater Studiorum' University of Bologna, S. Orsola Hospital, Bologna, Italy. malinf@med.unibo.it
Manfredi
Roberto
R
Colangeli
Vincenzo
V
Dentale
Nicola
N
Chiodo
Francesco
F
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D003131:Combined Modality Therapy; D015897:Comorbidity; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D006689:Hodgkin Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index