title: Inhibition by long-term fermented miso of induction of pulmonary adenocarcinoma by diisopropanolnitrosamine in Wistar rats.
abstract: The present study was designed to investigate the effects of fermented miso in the diet on the development of lung tumors initiated by diisopropanolnitrosamine (BHP) in male Slc:Wistar rats. A total of 63 animals, 6 weeks of age, were divided into 4 groups and given BHP (2000 ppm) in their drinking water for 10 weeks. After the carcinogen treatment the rats were fed a normal control MF solid diet, or the same diet containing 10% long-term or short-term fermented miso for 12 weeks. The long-term fermented miso significantly reduced the number of lung tumors, adenocarcinomas and PCNA strongly positive tumors as compared with the short-term fermented miso. The present results thus indicate that dietary supplementation with long-term fermented miso could exert chemopreventive effects on lung carcinogenesis.
authors.affiliation: Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima, 734-8553, Japan.
authors.forename: Kateuhisa
authors.initials: K
authors.lastname: Shiraki
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Une
authors.forename: Raita
authors.initials: R
authors.lastname: Yano
authors.forename: Satoko
authors.initials: S
authors.lastname: Otani
authors.forename: Akane
authors.initials: A
authors.lastname: Mimeoka
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000230:Adenocarcinoma / Q000517:prevention & control*; D000818:Animals; D004032:Diet; D005285:Fermentation; D008175:Lung Neoplasms / Q000517:prevention & control*; D008297:Male; D009602:Nitrosamines; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D013025:Glycine max
chemical_list: D009602:Nitrosamines; C012457:diisopropanolnitrosamine