All roads lead to ATF4.
Multiple intracellular stress pathways converge on a single event--phosphorylation of the translation initiation factor eIF2alpha and subsequent translational activation of the transcription factor ATF4. Exploring the consequences of this event has highlighted the ways in which stress is sensed and responded to via many distinct pathways.
Rutkowski
D Thomas
DT
Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
Kaufman
Randal J
RJ
D051701:Activating Transcription Factor 4; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*; D013312:Stress, Physiological / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D019892:eIF-2 Kinase / Q000235:genetics / Q000378:metabolism
D051701:Activating Transcription Factor 4; D000975:Antioxidants; D004268:DNA-Binding Proteins; D011506:Proteins; D014157:Transcription Factors; D019892:eIF-2 Kinase; C497109:ATF4 protein, human