[Respiratory effects of risperidone? A prospective study].
Risperidone is an atypical neuroleptic which has been incriminated as a cause of respiratory symptoms. The purpose of this prospective study was to assess over a three-month period the respiratory status of patients free of allergic or respiratory disease treated with risperidone. Thirty-nine patients were enrolled. Twenty dropped out. One patient developed cough very likely related to risperidone but with no change in function. Bronchial hyperreactivity developed in two other patients who had no clinical symptom or sign of respiratory disorder. Despite the small number of patients in this study, risperidone would appear to have secondary respiratory effects. The high frequency of bronchial hyperreactivity observed in patients at inclusin and the nearly constant co-prescription of other psychiatric drugs suggests a potential combination effect (notably with selective seritonin reuptake inhibitors).
Touraine
F
F
Service de Pathologie Respiratoire, Hôpital du Cluzeau, 51, avenue D.-Larrey, 87042 Limoges Cedex. bonnaud@unilim.fr
Antonini
M-T
MT
Bourlot
D
D
Trarieux
A-M
AM
Dalmay
F
F
Bonnaud
F
F
Lombertie
E
E
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D016535:Bronchial Hyperreactivity / Q000139:chemically induced* / Q000453:epidemiology; D003371:Cough / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018967:Risperidone / Q000009:adverse effects*
D014150:Antipsychotic Agents; D018967:Risperidone
Effets respiratoires de la rispéridone? Etude prospective.