Fulminant adenovirus hepatitis following bone marrow transplantation. A case report and brief review of the literature.
Adenovirus infections are frequently encountered in immunocompromised patients and transplant recipients. However, fulminant hepatic failure due to adenovirus infection as a fatal complication in bone marrow transplant recipients is extremely rare. We report a case of fulminant adenovirus hepatitis in a 21-year-old allogeneic bone marrow transplant recipient who subsequently died of the disease. The diagnosis was established by histologic and immunohistochemical examination of a liver biopsy and was confirmed by liver tissue and blood cultures.
Wang
Wei Hua
WH
Lauren V. Ackerman Laboratory of Surgical Pathology, Department of Pathology & Immunology, Washington University School of Medicine, St Louis, Mo 63110-1093, USA.
Wang
Hanlin L
HL
D000256:Adenoviridae / Q000302:isolation & purification; D000257:Adenoviridae Infections / Q000175:diagnosis; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000379:methods; D017809:Fatal Outcome; D006501:Hepatic Encephalopathy / Q000175:diagnosis*; D006525:Hepatitis, Viral, Human / Q000175:diagnosis*; D022781:Hepatocytes / Q000473:pathology / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000628:therapy; D008099:Liver / Q000473:pathology / Q000821:virology; D008297:Male