[Inhibition of human breast cancer cell line BCap-37 by flavonoid extract of wheat germ in vitro].
Cell growth and proliferation were measured by microculture tetrazolium(MTT) assay, cell colony-forming assay and the synthesis of DNA by 3H-thymidine incorporation. Flavonoid extract of wheat germ resulted to a dose-dependent, time-dependent growth inhibition, reduction of colony and 3H-thymiding incorporation in DNA of human breast cancer cell BCap-37. These findings indicated that the flavonoid extract of wheat germ can inhibit tumor cell growth and proliferation by blocking DNA synthesis in vitro.
Xu
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Department of Nutrition and Food Hygiene, Shandong Medical University, Jinan 250012, China.
Zhao
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Zhao
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Xu
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D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology*; D018276:Carcinoma, Medullary / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology; D014908:Triticum / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010936:Plant Extracts