title: Relationship of insulin sensitivity and left ventricular mass in uncomplicated obesity.
abstract: OBJECTIVE
  We studied uncomplicated obesity as a model to evaluate the influence of insulin sensitivity per se on left ventricular mass (LVM) and geometry.
  
  
  METHODS
  We selected 50 obese subjects (BMI > 30 kg/m(2); 38 women and 12 men; mean age, 38.4 +/- 10 years; BMI, 36.4 +/- 10.5 kg/m(2)) with normal blood pressure, glucose tolerance, and plasmatic lipid levels. Thirty lean subjects formed the control group. Each subject underwent euglycemic insulin clamp (7 pmol/min per kg) to evaluate whole body glucose use (M index) and echocardiogram to calculate LVM and indexed LVM.
  
  
  RESULTS
  Insulin-resistant obese subjects had higher LVM, LVM/h(2.7), LVM/body surface area, and LVM/fat-free mass(kg) (p = 0.001; p = <0.001 p = 0.001, and p = 0.04, respectively) than obese subjects with normal insulin sensitivity. Multivariate regression analysis showed that M index was the strongest independent correlate of LVM (r(2) = 0.34; p = 0.03).
  
  
  CONCLUSIONS
  Our findings showed that insulin resistance, in uncomplicated obesity, is associated with an increased LVM and precocious changes of left ventricular geometry, whereas preserved insulin sensitivity is not associated with increased LVM.
authors.affiliation: Endocrinology Section, Department of Clinical Sciences, University La Sapienza, Rome, Italy. gianluca.iaco@tin.it
authors.forename: Gianluca
authors.initials: G
authors.lastname: Iacobellis
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Ribaudo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Zappaterreno
authors.forename: Elio
authors.initials: E
authors.lastname: Vecci
authors.forename: Claudio
authors.initials: C
authors.lastname: Tiberti
authors.forename: Umberto
authors.initials: U
authors.lastname: Di Mario
authors.forename: Frida
authors.initials: F
authors.lastname: Leonetti
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015150:Echocardiography, Doppler; D005215:Fasting; D005260:Female; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications*; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D012044:Regression Analysis
chemical_list: D020738:Leptin