title: BRCA1 and BRCA2 germline mutations in lymphoma patients.
abstract: Mutations in the BRCA1 and BRCA2 tumor suppressor genes are associated with an increased risk for breast and ovarian cancers as well as other types of malignancies. The observation of a germline BRCA1 mutation in an index case with a lymphoid neoplasm in the setting of a family history of breast cancer prompted us to explore the role of BRCA germline mutations as lymphoma susceptibility alleles. A panel of 286 DNA samples from Jewish lymphoma patients was analyzed for the three most frequent BRCA1 and BRCA2 germline mutations in those of Ashkenazi Jewish heritage, and compared to a cohort of 5010 DNA samples from healthy controls. Of the 286 cases, 2 patients carried a germline BRCA mutation; both were diagnosed at an early age with an intermediate grade non-Hodgkin's lymphoma. This data indicate that germline BRCA mutations are not associated with an increased risk for lymphoid malignancies.
authors.affiliation: Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: Orit
authors.initials: O
authors.lastname: Yossepowitch
authors.forename: Narciso
authors.initials: N
authors.lastname: Olvera
authors.forename: Jaya M
authors.initials: JM
authors.lastname: Satagopan
authors.forename: Helen
authors.initials: H
authors.lastname: Huang
authors.forename: Sabrina
authors.initials: S
authors.lastname: Jhanwar
authors.forename: Beth
authors.initials: B
authors.lastname: Rapaport
authors.forename: Jeff
authors.initials: J
authors.lastname: Boyd
authors.forename: Kenneth
authors.initials: K
authors.lastname: Offit
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D018095:Germ-Line Mutation / Q000502:physiology*; D006801:Humans; D007585:Jews; D008223:Lymphoma / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010375:Pedigree
chemical_list: D019313:BRCA1 Protein; D024682:BRCA2 Protein