Absolute configuration and complete assignment of 13C NMR data for new sesquiterpenes from Maytenus chiapensis.
Five new dihydro-beta-agarofuran sesquiterpenes (1-5) were isolated from the leaves of Maytenus chiapensis. The structures of 1-5 were determined by means of 1D and 2D NMR techniques. A semiselective HMBC technique was applied in order to obtain complete (13)C NMR assignments. Absolute configurations were determined by CD studies and chemical correlations and on biogenetic grounds. Compound 4 showed weak activity against a multidrug-resistant Leishmania tropica line.
Núñez
Marvin J
MJ
Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain.
Cortés-Selva
Fernando
F
Bazzocchi
Isabel L
IL
Jiménez
Ignacio A
IA
González
Antonio G
AG
Ravelo
Angel G
AG
Gavin
José A
JA
D000818:Animals; D002247:Carbon Isotopes; D002460:Cell Line / Q000187:drug effects; D002942:Circular Dichroism; D018432:Drug Resistance, Multiple; D004544:El Salvador; D007895:Leishmania tropica / Q000187:drug effects*; D029755:Maytenus / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
D002247:Carbon Isotopes; D012717:Sesquiterpenes