title: [Toxicity of the ethanol extract of Magonia pubescens on larvae Aedes aegypti].
abstract: Crude ethanol extracted from Magonia pubescens trunks was utilized to prove its effect in the intestinal tract of Aedes aegypti 3rd instar larvae. Exposure times (2, 4, 6, 8, 10, 12, and 13 hours) were tested to verify when the morphological alterations begin to occur, in the intestinal tract of the larvae. The toxic effect of the extract was mainly in the midgut, beginning at the anterior midgut and followed through to posterior midgut. The main alterations observed were partial or total cell destruction, high citoplasmatic vacuolization, increase of subperitrophic space, cell hypertrophy and the epithelium did not maintain its monolayer appearance. The alterations began after four hours of exposure to M. pubescens extract. Observations of tissue sections from larvae treated for different lengths of time revealed a wide variation in the degree of damage between exposure periods and midgut larvae region. The present study provides evidence regarding the mode of action of the M. pubescens extract and suggests its potential utilization as a larvicide to control Aedes aegypti mosquito.
authors.affiliation: Departamento de Morfologia do Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil.
authors.forename: Walquíria
authors.initials: W
authors.lastname: Arruda
authors.forename: Gláucia Maria Cavasin
authors.initials: GM
authors.lastname: Oliveira
authors.forename: Ionizete Garcia
authors.initials: IG
authors.lastname: da Silva
mesh_terms: D000330:Aedes / Q000187:drug effects*; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D007422:Intestines / Q000187:drug effects; D007814:Larva / Q000187:drug effects; D010784:Photomicrography; D010936:Plant Extracts / Q000494:pharmacology; D029631:Sapindaceae / Q000737:chemistry*; D013997:Time Factors
chemical_list: D010936:Plant Extracts; D000431:Ethanol
vernacular_title: Toxicidade do extrato etanólico de Magonia pubescens sobre larvas de Aedes aegypti.