Experimental study of myocardial collagen during nifedipine therapy of arterial hypertension.
Light and electron microscopy of the left-ventricular myocardium obtained from spontaneously hypertensive SHR rats showed a pronounced increase in collagen content. These changes were more pronounced in animals treated with nifedipine in the mean therapeutic dose for 8 weeks. Collagen accumulated between muscle fibers and often formed perivascular cuffs. Hence, nifedipine promotes the formation of scleroproteins in the myocardium.
Frolov
V A
VA
Department of Pathological Physiology, Russian University of Peoples' Friendship, Moscow.
D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003094:Collagen / Q000096:biosynthesis*; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009543:Nifedipine / Q000627:therapeutic use*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D002121:Calcium Channel Blockers; D003094:Collagen; D009543:Nifedipine