The variable expression of the C4/5 complex of human butyrylcholinesterase and body mass index.
The activity of a supposedly heteromeric complex (C4/5) of butyrylcholinesterase (BChE; EC 3.1.1.8) was analyzed in relation to body mass index (BMI). The activities of the C4/5 and C(OF) (other molecular forms) bands in CHE2 C5- (n = 447) and CHE2 C5+ (n = 88) individuals were quantified by densitometry. Since the absolute activity of C4/5 (AC4/5) showed the highest correlation coefficient with weight in the CHE2 C5- phenotype when compared to the other BChE activity variables (total, relative C4/5, and absolute C(OF)), this variable was used for the classification of 51 CHE2 C5-individuals into three groups (low, average, and high), paired by sex, age, and ethnic origin. The low AC4/5 group was found to present a significantly (p < 0.0001) lower mean BMI (22.9) than the other groups (average = 25.2, and high = 26.3). In the CHE2 C5+ individuals no statistically significant standardized regression coefficient was verified between BMI (dependent variable) and the C4/5, band activities. These data show that the behavior of the C4/5 band in relation to BMI differs between the CHE2 C5- and CHE2 C5+ phenotypes. While the C5 band of the CHE2 C5+ individuals is negatively associated with fat storage in the adipose cells, the present data show that the C4/5 band is positively associated with this storage in the CHE2 C5- phenotype.
Alcântara
Vânia M
VM
Department of Medical Pathology, Federal University of Paraná, 80060-240 Curitiba, PR, Brazil.
Rodrigues
Luciane C
LC
Oliveira
Lisangela C
LC
Chautard-Freire-Maia
Eleidi A
EA
D000328:Adult; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D002091:Butyrylcholinesterase / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D005006:Ethnicity / Q000235:genetics; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D009765:Obesity / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype; D012044:Regression Analysis; D013851:Thinness / Q000453:epidemiology / Q000235:genetics*
D002091:Butyrylcholinesterase