title: [Intraoperative use of radiofrequency thermoablation of liver tumors: considerations on indications and related therapeutic aspects].
abstract: OBJECTIVE
  To evaluate the usefulness of intraoperative radiofrequency thermoablation of liver tumours in association or not with hepatic resection.
  
  
  METHODS
  21 patients were treated between January 1998 and December 2001, there were 4 hepatocellular carcinoma and 17 metastasis. In 13 cases radiofrequency was associated to hepatectomy, in 3 cases to resection of extraepatic disease and in 5 cases were performed alone. 23 lesions were treated by radiofrequency (range 1-3); the mean dimension was 26 millimetres (range 8-70). A clamping of the liver pedicle was always done.
  
  
  RESULTS
  There were no operative deaths, 3 (14.3%) patients developed complications related to radiofrequency (2 biliary leakages, 1 hepatic abscess). 14 (66.7%) patients were alive after a mean follow up of 14.5 months, 2 of all (9.5%) had a recurrence in the site previously treated with thermoablation. Association between hepatectomy and radiofrequency increased the number of curative liver resections from 10.1% to 16.3% (in case of colorectal metastasis).
  
  
  CONCLUSIONS
  Intraoperative radiofrequency is useful to increase the number of curative hepatectomies, to treat liver masses which demonstrate unresectable or found by ultrasonography at the operating time and even to reach tumours difficult to manage by percutaneous approach. In any case the aim is to obtain the absence of macroscopic neoplastic disease (RO status). It is a safe and effective therapeutic strategy, anyway all procedures and indications are still not completely cleared.
  
  
  CONCLUSIONS
  Intraoperative thermoablation of liver tumour is safe and effective and increases therapeutic the number of curative hepatectomies. Further progresses may improve the efficacy and extend the indications of this strategy.
authors.affiliation: II Divisione di Chirurgia Generale, Azienda Ospedaliera Santa Corona, Pietra Ligure (SV).
authors.forename: M
authors.initials: M
authors.lastname: Stella
authors.forename: M N
authors.initials: MN
authors.lastname: Minuto
authors.forename: M
authors.initials: M
authors.lastname: Pasqualini
authors.forename: A
authors.initials: A
authors.lastname: Percivale
authors.forename: A
authors.initials: A
authors.lastname: Profeti
authors.forename: G
authors.initials: G
authors.lastname: Serafini
authors.forename: N
authors.initials: N
authors.lastname: Gandolfo
authors.forename: G
authors.initials: G
authors.lastname: Marenco
authors.forename: E
authors.initials: E
authors.lastname: Azzola
authors.forename: R
authors.initials: R
authors.lastname: Pellicci
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000601:surgery* / Q000628:therapy; D017115:Catheter Ablation / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D013997:Time Factors
vernacular_title: L'impiego intraoperatorio della termoablazione a radiofrequenza di neoplasie epatiche: considerazioni su indicazioni ed aspetti terapeutici associati.