title: [Corpus callosum agenesis].
abstract: BACKGROUND
  Corpus callosum agenesis (CCA) is an uncommon entity, which can be diagnosed in utero. Uncertain prognosis makes prenatal counseling difficult. AIM. We have tried to establish a positive correlation between clinical history and imaging findings in patients with CCA.
  
  
  METHODS
  We retrospectively reviewed clinical data and imaging findings of patients with callosal agenesis diagnosed at our institution between December 1995 and September 2002.
  
  
  RESULTS
  Eight patients with CCA were found, five males and three females. Mean age at last clinical follow up was six years and six months, ranging from three months to 20 years. All diagnoses except for one were post natal. All patients underwent, at least, one magnetic resonance (MR) of the brain. Abnormal pregnancy was reported in three patients. Family history was unremarkable in all patients. Three patients were diagnosed with isolated CCA. One of these patients was asymptomatic at three months. Another had a slight language delay at seventeen months. The other patient had a mild developmental delay at five years. All other five patients had non isolated CCA and all were symptomatic, with variable clinical pictures: psicomotor developmental delay (4), epilepsy (4), hemiparesis (1), ocular apraxia (1), macrocephaly (2).
  
  
  CONCLUSIONS
  Non isolated CCA is likely to have a worse prognosis. This may be of significant value in prenatal counseling.
authors.affiliation: Servicio de Neurorradiología, Hospital Garcia de Orta, Almada, Portugal. Teresaandreia@yahoo.com
authors.forename: T
authors.initials: T
authors.lastname: Gonçalves-Ferreira
authors.forename: C
authors.initials: C
authors.lastname: Sousa-Guarda
authors.forename: J P
authors.initials: JP
authors.lastname: Oliveira-Monteiro
authors.forename: M J
authors.initials: MJ
authors.lastname: Carmo-Fonseca
authors.forename: P
authors.initials: P
authors.lastname: Filipe-Saraiva
authors.forename: A
authors.initials: A
authors.lastname: Goulão-Constâncio
mesh_terms: D000293:Adolescent; D000328:Adult; D061085:Agenesis of Corpus Callosum; D001921:Brain / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009421:Nervous System Malformations / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D013223:Statistics as Topic; D016216:Ultrasonography, Prenatal
vernacular_title: Agenesia del cuerpo calloso.