Epstein-Barr virus-related post-transplant lymphoproliferative disorder with t(9;14)(p11-12;q32).
The immunoglobulin heavy chain gene locus on 14q32 is known to be involved in translocations that are associated with B-lymphoproliferative disorders, typically Burkitt lymphoma and B-cell acute lymphoblastic leukemia. Several cytogenetic abnormalities have been described in post-transplant lymphoproliferatve disease (PTLD), some of which include this locus. To our knowledge, we report the first case of translocation t(9;14)(p11-12;q32) in a PTLD that developed after orthoptic liver transplantation.
Fasan
O
O
Department of Haematological Medicine, King's College Hospital, Denmark Hill London, United Kingdom.
Willmott
C
C
Czepulkowski
B
B
Baker
A
A
Rees
D
D
Salisbury
J
J
Mufti
G J
GJ
D001656:Biliary Atresia / Q000150:complications; D002648:Child; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005260:Female; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000150:complications / Q000235:genetics* / Q000821:virology*; D013997:Time Factors; D014178:Translocation, Genetic / Q000235:genetics*; D014314:Trisomy / Q000235:genetics