Corneal calcification after amniotic membrane transplantation.
BACKGROUND
/aims: Amniotic membrane transplantation (AMT) has become well established as a treatment for chronic epithelial defects, conjunctival reconstruction, and partial limbal cell deficiency. The aim of this study was to describe cases of corneal calcification following AMT and to search for risk factors that might predispose to this unusual finding.


METHODS
Details of 117 AMTs on 93 corneas of 91 patients with a follow up period of at least 1 month performed since 1999 were collected prospectively. In those with calcification clinical photographs were studied and the medical records retrospectively examined.


RESULTS
15 calcifications in 117 AMTs (12.8%) were identified, occurring 3-17 (median 6.1) weeks after AMT, during a follow up period of 4-151 (median 25) weeks. Overall epithelial healing rate was 83%. Calcification covered a surface area between 0.7-40.5 mm(2) maximum size with varied morphology. The primary diagnosis was diverse. Risk factors included the use of phosphate eye drops and pre-existing calcification in the operative or other eye. No patient with a "patch" AMT developed calcification.


CONCLUSIONS
Corneal calcification occurs after some cases of AMT. A common risk factor was the postoperative use of phosphate containing eye drops.
Anderson
S B
SB
Liverpool Royal University Hospital, Liverpool, UK Department of Ophthalmology, University of Erlangen-Nürnberg, Germany. asarah@hotmail.com
de Souza
R Ferreira
RF
Hofmann-Rummelt
C
C
Seitz
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000650:Amnion / Q000637:transplantation*; D002114:Calcinosis / Q000209:etiology*; D003316:Corneal Diseases / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000009:adverse effects; D010710:Phosphates / Q000009:adverse effects; D010781:Photography; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications / Q000209:etiology*; D012307:Risk Factors
D009883:Ophthalmic Solutions; D010710:Phosphates