[Evaluation of the metabolic state and functional activity of immunocompetent cells in children with relapsing herpetic viral infection].
Specific features of the immune response were studied (during the clinical remission period) in 40 children (aged 3 to 6) with a relapsing herpes viral infection (RHVI). The following was established: an increased relative and absolute quantity of lymphocytes, a reduced percentage content of CD+ and an increased absolute count of CD+ in the peripheral blood. Changes in the immunity humoral chain manifested themselves by an increased content of class G immunoglobulins and of circulating immune complexes (CIC) in the blood serum. A reduced quantity of phagocyting blood neutrophils was registered with the absorbing ability being preserved. Changes in the metabolic status of immune-competent cells were established; they were described by a high activity of the plastic exchange reaction, a tensed energetic potential and a reduced glutathione-recovery reaction modulating the proliferative activity of lymphocytes. A reduced reserve potential of oxygen-dependent biocenosis of neutrophyl granulocytes was detected in the peripheral blood. Obviously, the structural and metabolic changes in the blood lymphocytes as well as the abnormalities in the functional activity of neutrophyl granulocytes, observed during the clinical remission period in the RHVI period, are a cause predetermining the relapses of the disease and can be regarded as a criterion for applying the immune rehabilitation.
Kurtasova
L M
LM
Savchenko
A A
AA
Schmidt
A R
AR
Chesnokov
A B
AB
Ol'khovskiĭ
I A
IA
D002648:Child; D002675:Child, Preschool; D006561:Herpes Simplex / Q000201:enzymology / Q000276:immunology*; D018259:Herpesvirus 1, Human / Q000378:metabolism*; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008214:Lymphocytes / Q000201:enzymology* / Q000276:immunology; D009252:NADPH Dehydrogenase / Q000097:blood*; D009504:Neutrophils / Q000378:metabolism; D011379:Prognosis; D012008:Recurrence
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009252:NADPH Dehydrogenase
Otsenka metabolicheskogo sostoianiia i funktsional'noĭ aktivnosti immunokompetentnykh kletok u deteĭ s retsidiviruiushcheĭ gerpesvirusnoĭ infektsieĭ.