Synthesis of a novel aldehyde: 4-O-methyl-5-formylmethyl-2'-deoxyuridine.
The synthesis of the blocked nucleoside 3',5'-di-O-p-toluoyl-4-O-methyl-5-formylmethyl-2'-deoxyuridine was accomplishied in eleven steps from gamma-butyrolactone. This aldehyde, which should facilitate the synthesis of nucleosides containing 18F. was converted to the corresponding blocked dithianyl nucleoside, and also to 5-(2,2-difluoroethyl)-substituted derivatives of 2'-deoxyuridine and 2'-deoxycytidine.
Yu
Chung-Shan
CS
Abteilung E0300-Radiochemie und Radiopharmakologie, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Oberdorfer
Franz
F
D000447:Aldehydes / Q000737:chemistry; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry; D013936:Thymidine / Q000737:chemistry
C480514:4-O-methyl-5-formylmethyl-2'-deoxyuridine; D000447:Aldehydes; D011355:Prodrugs; D013936:Thymidine; D003857:Deoxyuridine