Humoral immunity reflects altered T helper cell bias in Borrelia burgdorferi-infected gamma delta T-cell-deficient mice.
In murine Lyme borreliosis, the absence of gamma delta T lymphocytes augments the T helper cell 2 type humoral response but does not alter disease susceptibility. Arthropod transmission of Borrelia burgdorferi spirochetes results in similar antibody isotypes when gamma delta T cells are present, suggesting that vector effects can negate gamma delta T-cell functions in vivo.
Bockenstedt
Linda K
LK
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA. linda.bockenstein@yale.edu
Shanafelt
Marie-Claude
MC
Belperron
Alexia
A
Mao
Jialing
J
Barthold
Stephen W
SW
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D025065:Borrelia burgdorferi / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification; D051379:Mice; D008807:Mice, Inbred BALB C; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D016692:Receptors, Antigen, T-Cell, gamma-delta