title: Role of GABA A and GABA B receptors in GABA-induced inhibition of rat red nucleus neurons.
abstract: We investigated GABA receptor subtypes mediating GABA-induced inhibition of red nucleus (RN) neuronal firing recorded extracellularly from anaesthetized rats. GABA response was mimicked by the GABA(A) agonists muscimol and isoguvacine in all cases and was partially blocked by the GABA(A) antagonist bicuculline. The GABA(B) agonist baclofen induced a long-lasting inhibition in 84% of cells. Neurons responding to either GABA(A) or GABA(B) agonists were equally distributed within the RN. The GABA(C) receptor agonist cis-amino-crotonic acid (CACA) did not modify RN neuronal firing; at high doses CACA occasionally induced inhibition abolished by bicuculline and thus mediated by GABA(A) receptors. We conclude that the inhibitory effects of GABA in the RN are mediated by both GABA(A) and GABA(B) receptors, whereas GABA(C) receptors are not involved.
authors.affiliation: Dipartimento di Scienze Fisiologiche, Università di Catania, Viale Andrea Doria 6, Italy. ciranna@unict.it
authors.forename: Lucia
authors.initials: L
authors.lastname: Ciranna
authors.forename: Flora
authors.initials: F
authors.lastname: Licata
authors.forename: Guido
authors.initials: G
authors.lastname: Li Volsi
authors.forename: Francesca
authors.initials: F
authors.lastname: Santangelo
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000502:physiology*; D018080:Receptors, GABA-B / Q000502:physiology*; D012012:Red Nucleus / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; D005680:gamma-Aminobutyric Acid