[Polymer coatings with immobilized thrombin and peptides: preparation and use for wound healing].
Polymer dressings with encapsulated thrombin or synthetic peptides which can mimic thrombin action are employed for wound healing. Paper describes the method for preparation of these hydrogel composites of PVCL-CaAlg [poly(N-vinyl caprolactam-calcium alginate). The effect of encapsulated thrombin/peptides on tissue repair process have beet investigatat in vivo experiments using a mouse model of wound healing. The developed dressings accelerated wound healing: thascan be used as a basis for creation of novel formulations with controlled drug release for wound therapy.
Markvicheva
E A
EA
Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Str. 16/10, Moscow, 117997 Russia. lemark@ibch.ru
Kuptsova
S V
SV
Rumsh
L D
LD
Dugina
T N
TN
Lange
M A
MA
Chistov
I V
IV
Strukova
S M
SM
Zubov
V P
VP
D000464:Alginates / Q000737:chemistry; D000818:Animals; D002209:Caprolactam / Q000031:analogs & derivatives* / Q000737:chemistry; D004337:Drug Carriers; D004800:Enzymes, Immobilized; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D020100:Hydrogels; D051379:Mice; D008808:Mice, Inbred CBA; D010446:Peptide Fragments / Q000737:chemistry* / Q000627:therapeutic use; D011108:Polymers / Q000737:chemistry; D044463:Receptor, PAR-1; D044464:Receptor, PAR-2; D018179:Receptors, Thrombin / Q000819:agonists; D013917:Thrombin / Q000737:chemistry* / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*
D000464:Alginates; D004337:Drug Carriers; D004800:Enzymes, Immobilized; D006603:Hexuronic Acids; D020100:Hydrogels; D010446:Peptide Fragments; D011108:Polymers; D044463:Receptor, PAR-1; D044464:Receptor, PAR-2; D018179:Receptors, Thrombin; C082835:thrombin receptor peptide (42-47); C086861:poly-N-vinylcaprolactam; D002209:Caprolactam; D020723:Glucuronic Acid; D013917:Thrombin
Polimernye pokrytiia s immobilizovannymi v nikh trombinom ili peptidami: poluchenie i primenenie dlia ranozazhivleniia.