TB or Not TB: how Mycobacterium tuberculosis may evade drug treatment.
In this issue of Cell, a study by Valerie Mizrahi and her colleagues suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanism for generating drug-resistant strains of M. tuberculosis.
Friedberg
Errol C
EC
Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Fischhaber
Paula L
PL
D000818:Animals; D004249:DNA Damage / Q000235:genetics; D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics*; D009169:Mycobacterium tuberculosis / Q000201:enzymology* / Q000235:genetics*; D018088:Tuberculosis, Multidrug-Resistant / Q000201:enzymology / Q000235:genetics* / Q000503:physiopathology
D004259:DNA-Directed DNA Polymerase