An oxytocin antagonist infused into the central nucleus of the amygdala increases maternal aggressive behavior.
Decreased oxytocin levels in the amygdalas of rat dams following chronic gestational cocaine exposure have been correlated with heightened maternal aggressive behavior. In this experiment, drug-naive dams were implanted with bilateral cannulas into the central nucleus of the amygdala (CNA) or control area and infused with 1,000 or 500 ng of an oxytocin antagonist (OTA) or buffer, 4 hr before testing. Behavior was compared among dams infused with OTA into target areas just outside the CNA and cocaine-treated dams (infused with buffer). Dams infused with 1,000 ng OTA attacked intruders significantly more often than buffer-infused dams. OTA did not affect other behaviors, suggesting that disruption of oxytocin activity in the CNA may be sufficient to selectively alter maternal aggressive behavior.
Lubin
Deborah A
DA
Department of Psychology, University of North Carolina at Chapel Hill, 27599, USA. debbie.lubin@rtp.ppdi.com
Elliott
Jay C
JC
Black
Mitchell C
MC
Johns
Josephine M
JM
D000374:Aggression / Q000187:drug effects*; D000679:Amygdala / Q000187:drug effects* / Q000503:physiopathology; D000779:Anesthetics, Local; D000818:Animals; D001522:Behavior, Animal; D003042:Cocaine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D006727:Hormone Antagonists / Q000494:pharmacology*; D008425:Maternal Behavior / Q000187:drug effects*; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D017557:Ventral Tegmental Area / Q000187:drug effects
D000779:Anesthetics, Local; D006727:Hormone Antagonists; C055830:KB 5-21; D010121:Oxytocin; D003042:Cocaine