title: Copper and zinc blood levels among children with nonorganic failure to thrive.
abstract: OBJECTIVE
  Copper and zinc deficiency are commonly reported among children with organic failure to thrive. In contrast, reports on copper and zinc status in children with non-organic failure to thrive are scarce. The goal of this study was to evaluate copper and zinc blood levels and nutritional intake among children with non-organic failure to thrive.
  
  
  METHODS
  A study group of 32 children with non-organic failure to thrive were investigated and compared with 32 healthy controls. Each child had copper and zinc blood level measurements. In addition, the study group underwent evaluation of thyroid function, immunoglobulins, endomesial antibodies and xylose test. A dietary questionnaire that included a diet history and a 24-h dietary recall was administered to parents by a dietician. Weight for height, height for age and mean daily intake of calories, protein, copper and zinc were calculated.
  
  
  RESULTS
  There were no significant differences between the two groups in either socioeconomic status or caloric, copper or zinc intake. Protein intake was significantly lower in the study group (P<0.0001). Plasma copper levels were within the normal range in both groups (P=0.3). Zinc plasma levels were significantly higher in the study group as compared to controls (P=0.03); however, they remained within the normal range in both groups.
  
  
  CONCLUSIONS
  Children with non-organic failure to thrive can maintain plasma copper and zinc levels within normal range and similar to normal controls.
authors.affiliation: Division of Pediatrics, Sackler School of Medicine, Tel-Aviv University, Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Berkovitch
authors.forename: E
authors.initials: E
authors.lastname: Heyman
authors.forename: R
authors.initials: R
authors.lastname: Afriat
authors.forename: I
authors.initials: I
authors.lastname: Matz-Khromchenko
authors.forename: M
authors.initials: M
authors.lastname: Avgil
authors.forename: R
authors.initials: R
authors.lastname: Greenberg
authors.forename: D R
authors.initials: DR
authors.lastname: Zimmerman
authors.forename: S
authors.initials: S
authors.lastname: Berman
authors.forename: J
authors.initials: J
authors.lastname: Weissgarten
mesh_terms: D016022:Case-Control Studies; D002675:Child, Preschool; D003300:Copper / Q000008:administration & dosage / Q000097:blood*; D004034:Diet Surveys; D004044:Dietary Proteins / Q000008:administration & dosage*; D002149:Energy Intake; D005183:Failure to Thrive / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011939:Mental Recall; D012016:Reference Values; D011795:Surveys and Questionnaires; D015032:Zinc / Q000008:administration & dosage / Q000097:blood*
chemical_list: D004044:Dietary Proteins; D003300:Copper; D015032:Zinc