Neopterin, biopterin, and nitric oxide concentrations in the cerebrospinal fluid of children with central nervous system infections.
We measured neopterin, biopterin and nitric oxide (NO) concentrations in the cerebrospinal fluid of pediatric patients with central nervous system (CNS) infectious diseases. The nitric oxide and neopterin concentrations were significantly elevated in encephalitis patients, especially in two cases with serious neurological sequelae, while the biopterin levels were not elevated. The bacterial meningitis patients, on the contrary, had high cerebrospinal fluid concentrations of neopterin and biopterin, but not of NO. Although these findings are preliminary, it may suggest that cerebrospinal fluids nitric oxide would be a useful marker to prospect neurological prognoses in the CNS infections.
Azumagawa
Kohji
K
Division of Pediatrics, Yao Tokusyu-kai General Hospital, 3-15-38 Kyuhoji, Yao-shi, Osaka 581-0072, Japan.
Suzuki
Shuhei
S
Tanabe
Takuya
T
Wakamiya
Eiji
E
Kawamura
Naohisa
N
Tamai
Hiroshi
H
D015415:Biomarkers / Q000134:cerebrospinal fluid; D001708:Biopterins / Q000134:cerebrospinal fluid*; D002494:Central Nervous System Infections / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D018792:Encephalitis, Viral / Q000134:cerebrospinal fluid; D006801:Humans; D007223:Infant; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid; D019798:Neopterin / Q000134:cerebrospinal fluid*; D009569:Nitric Oxide / Q000134:cerebrospinal fluid*
D015415:Biomarkers; D001708:Biopterins; D009569:Nitric Oxide; D019798:Neopterin