A model for studying the baroreflex in microgravity and hypergravity.
The study on development in altered gravity has been investigated in a wide range of animal species from a molecular level or cell culture to mammalian bodies. However development of the baroreflex has been studied in limited mammalian species even on the ground except the turtle to study diving reflex. The rat or mouse has been selectively used for studying the relationship between development of various functions and gravity especially microgravity, because of the limited body size for the loading space on the space ship, an experimental-animal most often used, and other biological characteristics. We have used the rat and rabbit for investigating the effect of microgravity on the development of the aortic baroflex. In the present paper a few results of our experiments using the rat will be shown and the appropriateness of the rat as a model system for studying the baroflex development in altered gravity will be discussed.
Shimizu
T
T
Dept. of Physiology, Fukushima Medical University School of Medicine, Fukushima, Japan.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001011:Aorta / Q000294:innervation; D001012:Aorta, Abdominal / Q000294:innervation; D017704:Baroreflex / Q000187:drug effects / Q000502:physiology*; D018471:Hypergravity; D023421:Models, Animal; D009599:Nitroprusside / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013026:Space Flight; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology; D014893:Weightlessness
D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D010656:Phenylephrine