title: Effect of an intraosseous injection of depo-medrol on pulpal concentrations of PGE2 and IL-8 in untreated irreversible pulpitis.
abstract: The purpose of this prospective, randomized, double-blind study was to evaluate the pulpal concentrations of prostaglandin E2 (PGE2) and interleukin-8 (IL-8) in untreated teeth with irreversible pulpitis after the administration of an intraosseous injection of Depo-Medrol. Forty emergency patients with a clinical diagnosis of irreversible pulpitis experiencing moderate to severe pain participated. After receiving local anesthesia, patients randomly received, in a double-blind manner, an intraosseous injection of either 1 ml of Depo-Medrol (40 mg) (20 patients) or 1 ml of sterile saline placebo (control) (20 patients). No endodontic treatment was initiated. At 1 or 3 days after the intraosseous injection, the teeth were extracted and the pulpal tissue harvested. Prostaglandin E2 and interleukin-8 concentrations were determined by enzyme immunoassay. Results demonstrated a significantly (p < 0.05) lower concentration of prostaglandin E2 compared to the saline group at day 1. There were no significant (p > 0.05) differences between the two groups at day 3. The pulpal concentrations of prostaglandin E2 were reduced at 1 day after the intraosseous injection of Depo-Medrol.
authors.affiliation: The Ohio State University, Columbus 43218, USA.
authors.forename: James
authors.initials: J
authors.lastname: Isett
authors.forename: Al
authors.initials: A
authors.lastname: Reader
authors.forename: Eric
authors.initials: E
authors.lastname: Gallatin
authors.forename: Mike
authors.initials: M
authors.lastname: Beck
authors.forename: David
authors.initials: D
authors.lastname: Padgett
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001842:Bone and Bones; D016009:Chi-Square Distribution; D003782:Dental Pulp / Q000737:chemistry; D015232:Dinoprostone / Q000378:metabolism*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007267:Injections; D016209:Interleukin-8 / Q000378:metabolism*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D000077555:Methylprednisolone Acetate; D010147:Pain Measurement; D011446:Prospective Studies; D011671:Pulpitis / Q000188:drug therapy* / Q000378:metabolism*; D018709:Statistics, Nonparametric; D014098:Toothache / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D016209:Interleukin-8; D000077555:Methylprednisolone Acetate; D015232:Dinoprostone; D008775:Methylprednisolone