title: Heart and brain: a case of focal myocytolysis in severe pneumococcal meningoencephalitis with review of the contemporary literature.
abstract: We report electrocardiographic changes mimicking myocardial ischaemia in a 73-year-old man with fatal pneumococcal meningoencephalitis, present the autopsy-confirmed histological picture of extensive focal myocytolysis (contraction band necrosis) without myocardial infarction or myocarditis, and review the contemporary literature. Potentially reversible, probably non-ischaemic myocardial dysfunction may occur in association with acute noncardiac illnesses, such as brain injuries. Biochemical and morphological abnormalities in acutely failing hearts from head-injured organ donors point to specific pathophysiological mechanisms, which are different from heart failure from other causes. Sepsis-related factors may add to the myocardial dysfunction in patients with brain injury from meningoencephalitis.
authors.affiliation: Department of Internal Medicine, Kantonsspital, Luzern, Switzerland. lukas.brander@insel.ch
authors.forename: L
authors.initials: L
authors.lastname: Brander
authors.forename: D
authors.initials: D
authors.lastname: Weinberger
authors.forename: C
authors.initials: C
authors.lastname: Henzen
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D009202:Cardiomyopathies / Q000150:complications / Q000473:pathology*; D004562:Electrocardiography; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000150:complications / Q000503:physiopathology*; D011008:Pneumococcal Infections / Q000150:complications / Q000503:physiopathology*