title: Electrochemical study of oxygen interaction with lapachol and its radical anions.
abstract: Cyclovoltammetric studies were performed with lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone], in the absence and presence of oxygen, which aimed to investigate possible oxygen interaction with lapachol and its radical anion. The obtained results clearly indicate the consumption of the semiquinone anion-radicals by oxygen in an EC type reaction, generating the deprotonated form of lapachol and HOO*. The observed generation of reactive oxygen species (ROS) after electron transfer can be related to the mechanism of biological action of lapachol.
authors.affiliation: Departamento de Química-CCEN Campus, Universidade Federal de Alagoas, Tabuleiro dos Martins, Maceio, Brazil. mofg@qui.ufal.br
authors.forename: Marília O F
authors.initials: MO
authors.lastname: Goulart
authors.forename: Piotr
authors.initials: P
authors.lastname: Falkowski
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Ossowski
authors.forename: Adam
authors.initials: A
authors.lastname: Liwo
mesh_terms: D002244:Carbon; D004563:Electrochemistry; D004566:Electrodes; D009285:Naphthoquinones / Q000737:chemistry*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry*
chemical_list: D009285:Naphthoquinones; D017382:Reactive Oxygen Species; D002244:Carbon; C008252:lapachol; D010100:Oxygen