Clear cell myomelanocytic tumor of the urinary bladder.
Clear cell myomelanocytic tumors are a recently described neoplastic growth considered to be a member of the family of perivascular epithelioid cell tumor. These tumors have a predilection for falciform ligament/ligamentum teres. We report an additional case arising from the muscularis propria of the urinary bladder in a 33-year-old woman. The tumor consisted of clear to eosinophilic, epithelioid, and spindled cells arranged in fascicles or packets. A delicate vascular stroma was found among the nests. Immunohistochemically, the tumor cells were typically positive for HMB-45 and smooth muscle actin but negative for S-100 protein, Melan-A, desmin, and pan-cytokeratin. The patient has been free of the disease since the excision of the tumor 6 years ago. This case, in association with the expanding list of perivascular epithelioid cell tumor reported in different sites, suggests that this type of neoplasm may be ubiquitous.
Pan
Chin-Chen
CC
Department of Pathology, National Yang-Ming University and Veterans General Hospital-Taipei,Taiwan. ccpan@vghtpe.gov.tw
Yu
I-Ting
IT
Yang
An-Hang
AH
Chiang
Hung
H
D018262:Adenocarcinoma, Clear Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor / Q000032:analysis; D015622:Epithelioid Cells / Q000737:chemistry / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008544:Melanocytes / Q000737:chemistry / Q000473:pathology*; D058950:Melanoma-Specific Antigens; D009130:Muscle, Smooth / Q000737:chemistry / Q000473:pathology*; D009363:Neoplasm Proteins / Q000032:analysis; D009379:Neoplasms, Muscle Tissue / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins