title: Tensile stress induced osteoblast differentiation and osteogenesis in mouse calvarial suture in culture: possible involvement of BMP-4 and other genes.
abstract: Mechanical stress is one of the most potent inducer of bone formation. The mechanism by which cells receive and transduce the signal into osteogenesis, however, remains unknown. Previous studies have demonstrated that mechanical stress causes changes in expression levels of many genes in osteoblasts and osteocytes both in vivo and in vitro. However, none of these changes are specific to bone cells. Moreover it is not clear which types of cells contributed to the increased osteoblasts induced by mechanical stress. The purpose of this study, therefore, was to identify which cells differentiate into osteoblasts and to examine how the expression of genes that are specific to osteogenic cells changes.
authors.affiliation: Department of Pharmacol., Faculty of Dentistry Niigata University, Niigata, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kawashima
authors.forename: M
authors.initials: M
authors.lastname: Ikegame
authors.forename: J
authors.initials: J
authors.lastname: Shimomura
authors.forename: O
authors.initials: O
authors.lastname: Ishibashi
authors.forename: T
authors.initials: T
authors.lastname: Komori
authors.forename: T
authors.initials: T
authors.lastname: Noda
authors.forename: H
authors.initials: H
authors.lastname: Ozawa
mesh_terms: D000818:Animals; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins / Q000235:genetics*; D003393:Cranial Sutures / Q000502:physiology*; D015870:Gene Expression; D037102:Lectins / Q000378:metabolism; D037181:Lectins, C-Type / Q000378:metabolism; D051379:Mice; D010006:Osteoblasts / Q000502:physiology; D010012:Osteogenesis / Q000235:genetics*; D013314:Stress, Mechanical
chemical_list: C525810:Bmp4 protein, mouse; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins; D037102:Lectins; D037181:Lectins, C-Type; C048648:tetranectin