One-shot memory in hippocampal CA3 networks.
The hippocampus plays a crucial role in the encoding and retrieval of episodic memory. In this issue of Neuron, Nakazawa and coworkers show that synaptic modification in hippocampal CA3 neurons is critical for immediate storage of information, a key feature of episodic memory.
Moser
Edvard I
EI
Centre for the Biology of Memory, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
Moser
May Britt
MB
D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology; D018782:Maze Learning; D008568:Memory / Q000502:physiology*; D051379:Mice; D009154:Mutation; D009415:Nerve Net / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D017966:Pyramidal Cells / Q000378:metabolism / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism; D013569:Synapses / Q000502:physiology*
C409466:NR1 NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate