title: Nuclear receptor ligands and cofactor recruitment: is there a coactivator "on deck"?
abstract: Farnesoid X receptor (FXR) is a bile acid sensor that regulates lipid homeostasis. New structural data suggest that, unlike other nuclear receptors, FXR contains a second coactivator binding site and binds bile acids with the steroid backbone flipped head to tail, both of which have important functional ramifications.
authors.affiliation: The Ben May Institute for Cancer Research, The University of Chicago, 5841 South Maryland Avenue, MC6027, Illinois 60637, USA.
authors.forename: Kendall W
authors.initials: KW
authors.lastname: Nettles
authors.forename: Geoffrey L
authors.initials: GL
authors.lastname: Greene
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D001665:Binding Sites / Q000187:drug effects / Q000502:physiology; D004268:DNA-Binding Proteins / Q000187:drug effects / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D017433:Protein Structure, Secondary / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D014157:Transcription Factors / Q000187:drug effects / Q000378:metabolism*; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D001647:Bile Acids and Salts; D004268:DNA-Binding Proteins; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D000099150:Receptor, Farnesoid X-Activated