High prevalence of PER-1 extended-spectrum beta-lactamase-producing Acinetobacter spp. in Korea.
PER-1, an extended-spectrum beta-lactamase, has been reported only in Europe. We detected PER-1 in 53 of 97 acinetobacters in Korea, mainly in the sputum of intensive care unit patients. Pulsed-field gel electrophoresis analysis suggested that clonal spread had occurred. Only PCR reliably detected PER-1 producers. PER-1 producers may also exist in other Asian countries.
Yong
Dongeun
D
Department of Laboratory Medicine, Research Institute of Bacterial Resistance. BK21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Shin
Jong Hee
JH
Kim
Sinyoung
S
Lim
Youngsik
Y
Yum
Jong Hwa
JH
Lee
Kyungwon
K
Chong
Yunsop
Y
Bauernfeind
Adolf
A
D000150:Acinetobacter / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D007723:Korea; D011550:Pseudomonas aeruginosa / Q000201:enzymology; D001618:beta-Lactamases / Q000032:analysis* / Q000096:biosynthesis
C108863:beta-lactamase PER-1; D001618:beta-Lactamases