Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?
The interface between luminal contents and intestinal epithelium constitutes the largest area of interaction between the host and the environment. There is now strong evidence that the gene product of the multidrug resistant pump (MDR) plays a critical role in host-bacterial interactions in the gastrointestinal tract and maintenance of intestinal homeostasis. This review highlights the efflux mechanism in the intestinal epithelium which is mediated by the multidrug resistant pump, also known as P-glycoprotein 170. Current studies promise to provide further insights into the contribution of the MDR1 gene in the pathogenesis of inflammatory and malignant disorders of the gastrointestinal tract.
Ho
G-T
GT
University Department of Medical Sciences, Western General Hospital, Edinburgh, UK. gho@ed.ac.uk
Moodie
F M
FM
Satsangi
J
J
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics* / Q000378:metabolism; D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D003093:Colitis, Ulcerative / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics; D003424:Crohn Disease / Q000235:genetics; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D018432:Drug Resistance, Multiple / Q000235:genetics*; D005767:Gastrointestinal Diseases / Q000235:genetics*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D019450:Genes, MDR / Q000235:genetics*; D006801:Humans; D005810:Multigene Family; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D051381:Rats
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000305:Adrenal Cortex Hormones; D003577:Cytochrome P-450 Enzyme System