title: [Churg-Strauss syndrome with alveolar hemorrhage].
abstract: A 35 year-old man was admitted to our hospital because of cough, wheezing, and paresthesia of the right upper extremity. He demonstrated marked eosinophilia, bronchial asthma, and mononeuritis multiplex. We diagnosed Churg-Strauss syndrome. Serum MPO-ANCA was elevated to 189 U/ml. Chest high-resolution computed tomography showed panlobular ground-glass attenuation in both lungs. BALF showed bloody fluid, and TBLB revealed findings consistent with eosinophilic pneumonia. Lung biopsy by VATS revealed eosinophilic pneumonia, pulmonary vasculitis, capillaritis, and hemosiderosis. The patient recovered after treatment with prednisolone and cyclophosphamide. We concluded that alveolar hemorrhage due to pulmonary capillaritis could be a complication in cases of Churg-Strauss syndrome.
authors.affiliation: Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, 1696 Itai, Kohnan, Ohsato, Saitama, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Matsushima
authors.forename: Noboru
authors.initials: N
authors.lastname: Takayanagi
authors.forename: Mikio
authors.initials: M
authors.lastname: Ubukata
authors.forename: Daidou
authors.initials: D
authors.lastname: Tokunaga
authors.forename: Nagato
authors.initials: N
authors.lastname: Sato
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kurashima
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yanagisawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sugita
authors.forename: Eishin
authors.initials: E
authors.lastname: Hoshi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kawabata
authors.forename: Minoru
authors.initials: M
authors.lastname: Kanazawa
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002196:Capillaries; D015267:Churg-Strauss Syndrome / Q000150:complications* / Q000175:diagnosis; D006470:Hemorrhage / Q000209:etiology*; D006486:Hemosiderosis / Q000150:complications / Q000473:pathology; D006801:Humans; D008168:Lung / Q000098:blood supply; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D011650:Pulmonary Alveoli; D011657:Pulmonary Eosinophilia / Q000150:complications / Q000473:pathology; D020775:Thoracic Surgery, Video-Assisted; D014657:Vasculitis / Q000150:complications / Q000473:pathology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers