title: [Long-term study of tiopronin in patients with cystinuria].
abstract: Thirty two patients with cystinuria were enrolled in this long-term study and 16 patients were treated with tiopronin for 24 weeks. Tiopronin reduced daily urinary cystine excretion from 901.48 mg (before treatment) to 488.60 mg (on the average of 12th week and 24th week after tiopronin administration) successfully. Tiopronin therapy was tolerated well, but side effects were observed in 13 events in 6 patients. Thus tiopronin was expected to be effective in preventing cystine stone formation and tolerated well.
authors.affiliation: Department of Urology, Osaka Kosei-Nenkin Hospital.
authors.forename: Takuo
authors.initials: T
authors.lastname: Koide
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Yoshioka
authors.forename: Osamu
authors.initials: O
authors.lastname: Miyake
authors.forename: Akihiko
authors.initials: A
authors.lastname: Okuyama
authors.forename: Sunao
authors.initials: S
authors.lastname: Yachiku
mesh_terms: D000328:Adult; D000368:Aged; D000855:Anorexia / Q000139:chemically induced; D003248:Constipation / Q000139:chemically induced; D003555:Cystinuria / Q000188:drug therapy* / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008625:Tiopronin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D008625:Tiopronin