[The changes in the sphingenine/sphinganine ratio in sphingolipids of transplantable rat tumors depends on a transplantation organ].
The content of sphingenine (sphingosine) and sphinganine was determined in the total pool of sphingomyelin and ceramide in the rat tumors transplanted subcutaneously and intrahepatically. The sphingenine/sphinganine ratio in the subcutaneously transplanted sarcoma M1 and cholangiocellular carcinoma RS1 was lower than that in the sphingolipids of the intrahepatically transplanted tumors. However, the sphingenine/sphinganine ratio in the subcutaneously transplanted rat hepatoma 27 was higher than in the intrahepatically transplanted hepatoma. These observations indicate that the sphingenine/sphinganine ratio in sphingolipids of tumors depends on the tumor type and its cellular microenvironment.
Kandyba
A G
AG
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997 Russia.
Kobliakov
V A
VA
Diatlovitskaia
E V
EV
D000818:Animals; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology; D002518:Ceramides / Q000737:chemistry / Q000378:metabolism; D018281:Cholangiocarcinoma / Q000378:metabolism / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology; D009374:Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology; D009928:Organ Specificity; D051381:Rats; D012513:Sarcoma, Experimental / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology; D013107:Sphingolipids / Q000737:chemistry / Q000378:metabolism*; D013109:Sphingomyelins / Q000737:chemistry / Q000378:metabolism; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism*; D023041:Xenograft Model Antitumor Assays
D002518:Ceramides; D013107:Sphingolipids; D013109:Sphingomyelins; D013110:Sphingosine; C005682:safingol
Izmenenie otnosheniia sfingenin/sfinganin v sfingolipidakh perevivaemykh opukholeĭ krys v zavisimosti ot organa transplantatsii.