title: Value of fetal skeletal radiographs in the diagnosis of fetal death.
abstract: The aim of this study was to assess the value of fetal skeletal radiographs in determining the etiology of fetal death. A total of 1193 post-mortem fetal skeletal radiographs were analysed. Fetuses were classified into one of three groups (group I: abnormality diagnosed during pregnancy; group II: maternal pathology; group III: spontaneous abortion of pregnancy, IIIa before 26 weeks of gestation (WG), IIIb after 26 weeks of gestation). Face, supine and lateral skeletal views were performed. Skeletal abnormalities were detected in 33.9% of the fetuses, including 22.7% with minor abnormalities (abnormal rib number, no nasal bone ossification, amesophalangia or P2 hypoplasia of the fifth digit) and 14.5% with major abnormalities (other skeletal abnormalities). Among the fetuses with major abnormalities, 98.8% came from group I, 2.9% came from group II, 2.3% came from group IIIa and none came from group IIIb. Fetal skeletal radiographs are not useful in fetuses arising from spontaneous abortion of pregnancy without abnormality on ultrasound screening, abnormality clinical examination or in fetuses with prenatal diagnosis of chromosomal abnormality. This practice is valuable only if there is a multidisciplinary team, with all the participants (pathologists, radiologists, geneticists) knowledgeable about fetal pathology. In the absence of this multidisciplinary approach, it is easier to X-ray all fetuses to avoid misdiagnosis and the important consequences for genetic counselling.
authors.affiliation: Department of Pediatric Radiology, CHU Timone, 264 rue St. Pierre, 13385 Marseille cedex 5, France. bbourliere@mail.ap-hm.fr
authors.forename: B
authors.initials: B
authors.lastname: Bourlière-Najean
authors.forename: A S
authors.initials: AS
authors.lastname: Russel
authors.forename: M
authors.initials: M
authors.lastname: Panuel
authors.forename: M D
authors.initials: MD
authors.lastname: Piercecchi-Marti
authors.forename: S
authors.initials: S
authors.lastname: Sigaudy
authors.forename: C
authors.initials: C
authors.lastname: Fredouille
authors.forename: P
authors.initials: P
authors.lastname: Petit
authors.forename: N
authors.initials: N
authors.lastname: Philip
authors.forename: P
authors.initials: P
authors.lastname: Devred
mesh_terms: D001847:Bone Diseases / Q000151:congenital / Q000175:diagnosis*; D001842:Bone and Bones / Q000002:abnormalities* / Q000000981:diagnostic imaging*; D002114:Calcinosis / Q000151:congenital / Q000175:diagnosis; D005121:Extremities / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005313:Fetal Death / Q000175:diagnosis*; D005315:Fetal Diseases / Q000175:diagnosis; D005333:Fetus / Q000002:abnormalities* / Q000000981:diagnostic imaging*; D005865:Gestational Age; D006801:Humans; D008297:Male; D011296:Prenatal Diagnosis; D011859:Radiography; D012189:Retrospective Studies; D012737:Sex Factors