title: Highly stereoselective synthesis of novel alpha-haloenamides via a mild and efficient hydrohalogenation of ynamides.
abstract: A highly stereoselective preparation of novel chiral (E)-alpha-haloenamides under mild conditions utilizing magnesium halide salts is described. This unexpected mild and efficient hydrohalogenation reaction highlights another synthetic utility of ynamides. [reaction: see text]
authors.affiliation: Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: Jason A
authors.initials: JA
authors.lastname: Mulder
authors.forename: Kimberly C M
authors.initials: KC
authors.lastname: Kurtz
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung
authors.forename: Heather
authors.initials: H
authors.lastname: Coverdale
authors.forename: Michael O
authors.initials: MO
authors.lastname: Frederick
authors.forename: Lichun
authors.initials: L
authors.lastname: Shen
authors.forename: Craig A
authors.initials: CA
authors.lastname: Zificsak