Cranial MRI scans are indicated in all girls with central precocious puberty.
OBJECTIVE
(1) To assess the value of cranial magnetic resonance imaging (MRI) scans in the investigation of girls with central precocious puberty (CPP); and (2) to determine the clinical predictors of abnormal cranial MRI scans in these patients.


METHODS
A retrospective study of 67 girls diagnosed with CPP who underwent cranial MRI scans at diagnosis. Patients with neurological signs or symptoms at presentation were excluded.


RESULTS
The mean age of onset of puberty was 6.2 years (range 2.0-7.9). Intracranial abnormalities were present in 10 (15%) patients (MR+), while 57 (85%) had no abnormalities (MR-). There was no statistical difference between MR+ patients and MR- patients at presentation with respect to age of onset of puberty, pubertal stage, bone age advance, pelvic ultrasound findings, or height or body mass index standard deviation scores (SDS).


CONCLUSIONS
Girls with CPP should have a cranial MRI scan as part of their assessment since clinical features, including age, are not helpful in predicting those with underlying pathology. Implementation of such an approach may have a substantial effect on clinical practice and healthcare cost.
Ng
S M
SM
Endocrinology Department, Royal Liverpool Chidren's Hospital, Liverpool, UK. ngszemay@yahoo.com
Kumar
Y
Y
Cody
D
D
Smith
C S
CS
Didi
M
M
D017668:Age of Onset; D016080:Arachnoid Cysts / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D001254:Astrocytoma / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use; D006222:Hamartoma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010388:Pelvis / Q000000981:diagnostic imaging; D011629:Puberty, Precocious / Q000209:etiology* / Q000628:therapy; D012189:Retrospective Studies; D013724:Teratoma / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D014463:Ultrasonography
D007987:Gonadotropin-Releasing Hormone