[Hypermethylation status of blu gene in nasopharyngeal lymphoma].
OBJECTIVE
To investigate the hypermethylation status of blu gene promoter in nasopharyngeal NK/T cell lymphoma and its role in the tumorigenesis and molecular diagnosis of this lymphoma.


METHODS
Twenty cases of paraffin-embedded nasopharyngeal NK/T cell lymphomas tissues were studied by using methylation specific PCR (MSP).


RESULTS
Hypermethylation of blu gene promoter is detected in 6 of 20 (30%) nasopharyngeal NK/T cell lymphoma. The 6 positive cases were 4 in 15 nasopharyngeal NK cell lymphomas, 1 of 2 NK like T cell lymphoma and 1 in 3 peripheral T cell lymphomas (unspecified type).


CONCLUSIONS
Hypermethylation of blu gene promoter in nasopharyngeal NK/T cell lymphoma indicated the inactivation of blu gene and its possible role in the tumorigenesis of this lymphoma. blu gene methylation could be detected in paraffin-embedded tissue and used as a new molecular marker for the diagnosis of this lymphoma.
Zhang
Xiao-hua
XH
Department of Pathology, Peking University Health Science Center, Beijing 100083, China.
Jiang
Fen
F
Li
Min
M
Xu
Qing
Q
Li
Ning
N
Tao
Qian
Q
Gao
Zi-fen
ZF
D003598:Cytoskeletal Proteins; D019175:DNA Methylation; D016147:Genes, Tumor Suppressor; D006801:Humans; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D016133:Polymerase Chain Reaction / Q000379:methods; D025521:Tumor Suppressor Proteins
D003598:Cytoskeletal Proteins; D025521:Tumor Suppressor Proteins; C472720:ZMYND10 protein, human