[Stability of immobilized insulin preparation at various pH].
The stability of polyacrylamide hydrogel, modified by ovomucoid with immobilized insulin was studied at different pH of external medium. At 3.8 < pH < 5.5 insulin binds to the gel, due to electrostatic interaction between ovomucoid and insulin molecules.
Valuev
I L
IL
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Leninsky prospect, 29, Moscow, 117912 Russia. ivaluev@ips.ac.ru
Sytov
G A
GA
Valuev
L I
LI
Vanchugova
L V
LV
Pan
A V
AV
Ul'ianova
M V
MV
Platé
N A
NA
D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D004337:Drug Carriers; D004355:Drug Stability; D004372:Ducks; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000737:chemistry*; D007700:Kinetics; D009994:Osmolar Concentration; D010059:Ovomucin / Q000737:chemistry; D000099166:Polyacrylamides
D000180:Acrylic Resins; D004337:Drug Carriers; D020100:Hydrogels; D007328:Insulin; D010059:Ovomucin; D000099166:Polyacrylamides
Stabil'nost' preparata immobilizovannogo insulina pri razlichnykh pH.