title: Closing the GAP: a role for a RhoA GAP in cytokinesis.
abstract: During cell division, cytokinesis partitions the cytoplasm to form two daughter cells. Recently in Developmental Cell, Minoshima et al. (2003) establish an important connection between three regulatory molecules that coordinate this process, showing that the mitotic kinase aurora B phosphorylates MgcRacGAP to convert it to a GAP for RhoA, a small GTPase that drives cytokinesis.
authors.affiliation: Ludwig Institute for Cancer Research, University of California, San Diego, CMM-East 3080, 9500 Gilman Drive, La Jolla 92093, USA.
authors.forename: Amy Shaub
authors.initials: AS
authors.lastname: Maddox
authors.forename: Karen
authors.initials: K
authors.lastname: Oegema
mesh_terms: D008841:Actin Cytoskeleton / Q000235:genetics / Q000378:metabolism; D000818:Animals; D064107:Aurora Kinase B; D064127:Aurora Kinases; D002455:Cell Division / Q000235:genetics*; D005057:Eukaryotic Cells / Q000201:enzymology*; D020690:GTPase-Activating Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008870:Microtubules / Q000235:genetics / Q000378:metabolism; D009218:Myosins / Q000235:genetics / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D020742:rhoA GTP-Binding Protein / Q000235:genetics / Q000378:metabolism*
chemical_list: D020690:GTPase-Activating Proteins; C115995:mgcRacGAP; C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases; D009218:Myosins; D020742:rhoA GTP-Binding Protein