title: Contribution of systemic vascular resistance and total arterial compliance to effective arterial elastance in humans.
abstract: The respective contribution of systemic vascular resistance (R) and total arterial compliance (C) to the arterial load remains to be established in humans. Effective arterial elastance (Ea), i.e., the left ventricular end-systolic pressure (LVESP)-over-stroke volume ratio, is a reliable estimate of arterial load. It is widely accepted that Ea mainly relates to mean aortic pressure (MAP) and thus to the R-to-T ratio (R/T ratio), where T is cycle length. We tested the contribution of R/T and 1/C to Ea in 20 normotensive and 46 hypertensive subjects (MAP range: 84-160 mmHg). The multilinear model applied (Ea = 1.00R/T + 0.42/C - 0.04; r2 = 0.97). The sensitivity of Ea to a change in R/T was 2.5 times higher than to a similar change in 1/C in both normotensive and hypertensive adults. The LVESP was more strongly related to systolic aortic pressure (SAP; r2 = 0.94) than to MAP (r2 = 0.83), and LVESP matched 90% SAP (bias = 0 +/- 5mmHg). An alternative model of Ea is proposed, in which Ea is proportional to the heart rate x SAP product-over-cardiac index ratio whatever the MAP.
authors.affiliation: Service de Physiologie Cardio-Respiratoire, Centre Hospitalier Universitaire de Bicêtre, Assistance Publique-Hôpitaux de Paris, 94 275 Le Kremlin-Bicêtre Cedex, France. denis.chemla@bct.ap-hop-paris.fr
authors.forename: Denis
authors.initials: D
authors.lastname: Chemla
authors.forename: Isabelle
authors.initials: I
authors.lastname: Antony
authors.forename: Yves
authors.initials: Y
authors.lastname: Lecarpentier
authors.forename: Alain
authors.initials: A
authors.lastname: Nitenberg
mesh_terms: D001011:Aorta / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D003187:Compliance; D004548:Elasticity; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology*