title: [Exploration of acute graft versus host disease and its risk factors after allo-hematopoietic stem cell transplantation].
abstract: OBJECTIVE
  To explore the incidence, prognosis and risk factors of the acute graft versus host disease (aGVHD) after allo-hematopoietic stem cell transplantation (allo-HSCT).
  
  
  METHODS
  The clinical data of 118 cases undergone 120 times of allo-HSCT were analyzed.
  
  
  RESULTS
  aGVHD was observed in 63 cases (52.57%) including 17 severe cases (14.17%). The patients with aGVHD had a poor outcome, the 2-year overall survival rates were 61.40%, 64.08% and 17.65% for the non aGVHD, mild (degree I-II) and severe (degree III-IV) aGVHD groups respectively (P < 0.01). However, the relapse rates were 12.48%, 20.53% and 0% with no statistic significance. Unrelated transplantation and HLA-mismatch were the risk factors for aGVHD.
  
  
  CONCLUSIONS
  aGVHD is a common complication after allo-HSCT, the earlier it takes place, the poorer the prognosis.
authors.affiliation: Institute of Hematology and People's Hospital of Peking University, Beijing 100044, China.
authors.forename: Yu-hong
authors.initials: YH
authors.lastname: Chen
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Huang
authors.forename: Nai-lan
authors.initials: NL
authors.lastname: Guo
authors.forename: Han-yun
authors.initials: HY
authors.lastname: Ren
authors.forename: Yao-chen
authors.initials: YC
authors.lastname: Zhang
authors.forename: Lan-ping
authors.initials: LP
authors.lastname: Xu
authors.forename: Zhi-yong
authors.initials: ZY
authors.lastname: Gao
authors.forename: Dao-pei
authors.initials: DP
authors.lastname: Lu
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D016019:Survival Analysis; D013997:Time Factors; D014184:Transplantation, Homologous