title: New stigmastane sterols from Ajuga salicifolia.
abstract: A new sterol, ajugasalicigenin (1), and three new sterol glycosides, ajugasaliciosides F-H (2-4), were isolated and characterized from the aerial parts of Ajuga salicifolia. Compounds 1-4 are further representatives of the stigmastane type of sterols. Their cytotoxicity against KB (HeLa) and Jurkat T cancer cells was evaluated.
authors.affiliation: Department of Applied BioSciences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, CH-8057 Zürich, Switzerland.
authors.forename: Pinar
authors.initials: P
authors.lastname: Akbay
authors.forename: Ihsan
authors.initials: I
authors.lastname: Calis
authors.forename: Jörg
authors.initials: J
authors.lastname: Heilmann
authors.forename: Otto
authors.initials: O
authors.lastname: Sticher
mesh_terms: D031328:Ajuga / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D019169:Jurkat Cells / Q000187:drug effects; D007624:KB Cells / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014421:Turkey
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D013261:Sterols; C477612:ajugasalicigenin