title: Imaging of the 5-HT2A system: age-, gender-, and Alzheimer's disease-related findings.
abstract: Serotonin (5-HT) and more specifically the 5-HT(2A) receptor is involved in cognitive and non-cognitive behavior and plays an important role in Alzheimer's disease (AD). The objective was to assess the 5-HT(2A) binding potential (BP) in healthy volunteers and AD with SPECT and 123I-5-I-R91150, a selective radio-iodinated 5-HT(2A) receptor antagonist. Twenty-six controls and nine AD patients were included. A semiquantitive analysis with normalization on cerebellar uptake provided estimates of BP for 26 cortical regions of interest. An age-related decline of neocortical BP was found (11.6% per decade). Compared to age-matched controls, a generally decreased neocortical BP in AD was found with a significant regional reduction in the orbitofrontal, prefrontal, lateral frontal, cingulate, sensorimotor, parietal inferior, and occipital region. These results are in line with previous postmortem, in vitro, and PET findings. The age-related decline highlights the necessity for matched advanced age study samples. The fact that the 5-HT(2A) receptor is differentially affected in AD patients has implications for both the etiological basis and therapeutic management of AD.
authors.affiliation: Department of Biological Psychiatry, Groningen University Hospital, Groningen, The Netherlands. jan.versijpt@rug.ac.be
authors.forename: J
authors.initials: J
authors.lastname: Versijpt
authors.forename: K J
authors.initials: KJ
authors.lastname: Van Laere
authors.forename: F
authors.initials: F
authors.lastname: Dumont
authors.forename: Danny
authors.initials: D
authors.lastname: Decoo
authors.forename: Marleen
authors.initials: M
authors.lastname: Vandecapelle
authors.forename: Patrick
authors.initials: P
authors.lastname: Santens
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Goethals
authors.forename: K
authors.initials: K
authors.lastname: Audenaert
authors.forename: G
authors.initials: G
authors.lastname: Slegers
authors.forename: Rudi A
authors.initials: RA
authors.lastname: Dierckx
authors.forename: Jakob
authors.initials: J
authors.lastname: Korf
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000378:metabolism*; D012737:Sex Factors; D018709:Statistics, Nonparametric; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin