5-HT3 receptors in the CNS: 3B or not 3B?
5-HT(3) receptors are widely distributed in the CNS and PNS where they participate in a variety of physiological processes. Native 5-HT(3) receptors in the CNS display functional and pharmacological heterogeneity, suggesting the existence of multiple receptor subunits. However, recent evidence suggests that of the two known subunits only the 5-HT(3A) receptor subunit (and not the 5-HT(3B) receptor subunit) is functionally present in the CNS. The molecular makeup of the 5-HT(3) receptor therefore remains an open question.
van Hooft
Johannes A
JA
University of Amsterdam, Swammerdam Institute for Life Sciences, section Neurobiology, PO Box 94084, NL-1090 GB Amsterdam, The Netherlands.
Yakel
Jerrel L
JL
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003001:Cloning, Molecular; D006801:Humans; D009928:Organ Specificity; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011985:Receptors, Serotonin / Q000235:genetics / Q000378:metabolism*; D044406:Receptors, Serotonin, 5-HT3; D013116:Spinal Cord / Q000378:metabolism*
D021122:Protein Subunits; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3