[The functional role of arterial intima. Endogenous and exogenous pathogens and specificity of atheromatosis as an inflammation].
We believe that the intima is a biological filter accountable for arresting the endogenous and exogenous pathogens, which activate the biological function of inflammation, and for preventing the access of pathogens into the internal-space intercellular pool. The below described biological reactions occur in the arterial intima: trans-cytosis of pathogens by endothelial cells onto the intima surface; sorption of pathogens into the filter proteoglycan matrix; destruction of the matrix by macrophage metalloproteinases; desorption of pathogens with matrix elements by resident macrophages through squewenjer-receptor endocytosis; proteolysis of pathogens in lysosomes; retroendocytosis of non-hydrolyzed components of pathogens into the intercellular medium; and a recovery of the integrity of proteoglycan matrix by the smooth-muscle cells. Sorption and desorption of pathogens (i.e. modified low-density lipoproteins who carry the essential polyene fat acids to cells) by resident macrophages (from the filter) under the conditions of the blockade of apoB-100-receptoral endocytosis predetermine the specificity of atheromatosis as an inflammation.
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D001158:Arteries / Q000033:anatomy & histology; D001161:Arteriosclerosis / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D005110:Extracellular Space / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008077:Lipoproteins, LDL / Q000097:blood / Q000378:metabolism; D008264:Macrophages / Q000201:enzymology / Q000378:metabolism*; D008666:Metalloendopeptidases / Q000378:metabolism; D008954:Models, Biological; D009131:Muscle, Smooth, Vascular / Q000378:metabolism* / Q000473:pathology; D011956:Receptors, Cell Surface / Q000378:metabolism; D017539:Tunica Intima / Q000378:metabolism* / Q000473:pathology
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D008077:Lipoproteins, LDL; D011956:Receptors, Cell Surface; D008666:Metalloendopeptidases
Funktsional'naia rol' intimy arteriĭ. Endogennye, ékzogennye patogeny i spetsifichnost' ateromatoza kak vospaleniia.