title: Axon regeneration in young adult mice lacking Nogo-A/B.
abstract: After injury, axons of the adult mammalian brain and spinal cord exhibit little regeneration. It has been suggested that axon growth inhibitors, such as myelin-derived Nogo, prevent CNS axon repair. To investigate this hypothesis, we analyzed mice with a nogo mutation that eliminates Nogo-A/B expression. These mice are viable and exhibit normal locomotion. Corticospinal tract tracing reveals no abnormality in uninjured nogo-A/B(-/-) mice. After spinal cord injury, corticospinal axons of young adult nogo-A/B(-/-) mice sprout extensively rostral to a transection. Numerous fibers regenerate into distal cord segments of nogo-A/B(-/-) mice. Recovery of locomotor function is improved in these mice. Thus, Nogo-A plays a role in restricting axonal sprouting in the young adult CNS after injury.
authors.affiliation: Department of Neurology, Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Shuxin
authors.initials: S
authors.lastname: Li
authors.forename: Tadzia
authors.initials: T
authors.lastname: GrandPré
authors.forename: Dike
authors.initials: D
authors.lastname: Qiu
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Strittmatter
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D019771:Axotomy; D001921:Brain / Q000166:cytology; D005260:Female; D005328:Fetal Viability / Q000235:genetics; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000502:physiology; D009185:Myelin Proteins / Q000172:deficiency* / Q000235:genetics; D009186:Myelin Sheath / Q000502:physiology; D009416:Nerve Regeneration / Q000235:genetics / Q000502:physiology; D000070798:Nogo Proteins; D010641:Phenotype; D011712:Pyramidal Tracts / Q000166:cytology / Q000473:pathology; D020127:Recovery of Function / Q000235:genetics; D013037:Spatial Behavior / Q000502:physiology; D013119:Spinal Cord Injuries / Q000235:genetics / Q000473:pathology / Q000503:physiopathology
chemical_list: D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603201:Rtn4 protein, mouse