title: Synthesis and collateral dilator activity of nitroxyalkylamides having direct or latent sulfhydryl moieties.
abstract: To develop an orally active, long-acting nitrate that does not induce tolerance, nitroxyalkyl compounds were prepared and their activities evaluated by the use of carotid collaterals in anesthetized dogs. A compound having a favorable pharmacological profile, that is, long-lasting collateral vasodilatation and little hypotension, and lack of nitrate tolerance, was chosen for further evaluation.
authors.affiliation: Research Laboratories, Sankyo Co., Ltd., Hiromachi, Shinagawa-ku, Tokyo 140, Japan. isiwar@shina.sankyo.co.jp
authors.forename: Sadao
authors.initials: S
authors.lastname: Ishihara
authors.forename: Fujio
authors.initials: F
authors.lastname: Saito
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohhata
authors.forename: Marie
authors.initials: M
authors.lastname: Kanai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mizuno
authors.forename: Michio
authors.initials: M
authors.lastname: Fujisawa
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Yorikane
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koike
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002339:Carotid Arteries; D003097:Collateral Circulation / Q000187:drug effects*; D003545:Cysteine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D004285:Dogs; D004361:Drug Tolerance; D007275:Injections, Intravenous; D008297:Male; D009566:Nitrates / Q000138:chemical synthesis* / Q000494:pharmacology; D020030:Nitric Oxide Donors / Q000138:chemical synthesis* / Q000494:pharmacology; D005996:Nitroglycerin / Q000494:pharmacology; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014665:Vasodilator Agents / Q000009:adverse effects / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D009566:Nitrates; D020030:Nitric Oxide Donors; D013438:Sulfhydryl Compounds; D013844:Thiazoles; D014665:Vasodilator Agents; D005996:Nitroglycerin; D003545:Cysteine