title: A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi.
abstract: We report the molecular characterization of a novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi. Steady-state level of transcripts of this sequence family appeared to be developmentally regulated, since only in the replicative forms the parasite showed expression of related sequences with a major band around 3 kb. The presence of frame shifts or premature stop codons predicts that transcripts are not translated. The sequence family also contains truncated forms of retrotransposons elements that may become potential hot spots for retroelement insertion. Sequences homologous to this family are interspersed at many chromosomes including the subtelomeric regions.
authors.affiliation: Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, São Paulo, SP, 04023-062, Brasil.
authors.forename: Newton Valério
authors.initials: NV
authors.lastname: Verbisck
authors.forename: Márcia Regina Machado
authors.initials: MR
authors.lastname: dos Santos
authors.forename: David M
authors.initials: DM
authors.lastname: Engman
authors.forename: Miguel
authors.initials: M
authors.lastname: Angel Chiurillo
authors.forename: José Luis
authors.initials: JL
authors.lastname: Ramirez
authors.forename: Jorge Enrique
authors.initials: JE
authors.lastname: Araya
authors.forename: Renato Arruda
authors.initials: RA
authors.lastname: Mortara
authors.forename: José Franco
authors.initials: JF
authors.lastname: da Silveira
mesh_terms: D000818:Animals; D016054:DNA, Protozoan / Q000235:genetics*; D018503:Genome, Protozoan; D020071:Interspersed Repetitive Sequences / Q000235:genetics*; D014349:Trypanosoma cruzi / Q000235:genetics*
chemical_list: D016054:DNA, Protozoan