title: Do circulating cytokines really matter in sepsis?
abstract: Sepsis remains the major cause of mortality worldwide, claiming millions of lives each year. The past decade has seen major advances in the understanding of the biological mechanisms involved in this complex process. Unfortunately, no definitive therapy yet exists that can successfully treat sepsis and its complications. In this review, we will address the significance of circulating cytokines in the pathophysiology of sepsis and its relevance to new approaches in extracorporeal therapies.
authors.affiliation: Renal Research, Division of Medicine, Fresenius Medical Care, Bad Homburg, Germany. ciro.tetta@fmc-ag.com
authors.forename: Ciro
authors.initials: C
authors.lastname: Tetta
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Bellomo
authors.forename: Vincent
authors.initials: V
authors.lastname: D'Intini
authors.forename: Concetta
authors.initials: C
authors.lastname: De Nitti
authors.forename: Paola
authors.initials: P
authors.lastname: Inguaggiato
authors.forename: Alessandra
authors.initials: A
authors.lastname: Brendolan
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
mesh_terms: D016207:Cytokines / Q000097:blood*; D006440:Hemofiltration; D006801:Humans; D018805:Sepsis / Q000276:immunology* / Q000503:physiopathology* / Q000628:therapy
chemical_list: D016207:Cytokines