title: Theoretical and experimental model to describe the injection of a polymethylmethacrylate cement into a porous structure.
abstract: A theoretical approach was used to determine the distribution of a poly(methylmethacrylate) cement after its injection into a porous structure. The predictions of the model were then compared to experimental results obtained by injecting a polymethylmethacrylate cement into an open-porous ceramic filter. The goal was to define a model that could predict what factors affect the risk of cement extravasation and hence how the risk of cement extravasation can be minimized. The calculations were based on two important rheological laws: the law of Hagen-Poiseuille and the law of Darcy. The law of Hagen-Poiseuille describes the flow of a fluid in a cylindrical tube. The law of Darcy describes the flow of a fluid through a porous media. The model predicted that the extravasation risk was decreased when the cement viscosity, the bone pore size, the bone permeability and the bone porosity were increased, and when the diameter of the extravasation path and the viscosity of the marrow were decreased. Experimentally, the effect of the marrow viscosity and extravasation path could be evidenced. Therefore, the model was believed to be an adequate approximation of the experimental behavior. In conclusion, the experimental results demonstrated that the model was adequate and that the best practical way to decrease the risk of extravasation is to increase the cement viscosity.
authors.affiliation: Dr Robert Mathys Foundation, Bischmattstrasse 12, CH-2544 Bettlach, Switzerland. marc.bohner@rms-foundation.ch
authors.forename: M
authors.initials: M
authors.lastname: Bohner
authors.forename: B
authors.initials: B
authors.lastname: Gasser
authors.forename: G
authors.initials: G
authors.lastname: Baroud
authors.forename: P
authors.initials: P
authors.lastname: Heini
mesh_terms: D001843:Bone Cements / Q000737:chemistry* / Q000627:therapeutic use; D002484:Cementation / Q000379:methods*; D003198:Computer Simulation; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000517:prevention & control*; D050723:Fractures, Bone / Q000188:drug therapy; D007267:Injections / Q000379:methods*; D008422:Materials Testing / Q000379:methods; D008954:Models, Biological; D008956:Models, Chemical; D010024:Osteoporosis / Q000188:drug therapy; D010539:Permeability; D019904:Polymethyl Methacrylate / Q000008:administration & dosage / Q000737:chemistry* / Q000627:therapeutic use; D016062:Porosity; D012212:Rheology / Q000379:methods; D014783:Viscosity
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate