title: Echocardiographic Doppler assessment of pulmonary capillary wedge pressure in surgical patients with postoperative circulatory shock and acute lung injury.
abstract: BACKGROUND
  In cardiac patients, pulmonary capillary wedge pressure (PCWP) is estimated using color M-mode Doppler study of left ventricular filling and Doppler tissue imaging. The goal of this study was to assess whether echocardiography accurately estimates PCWP in critically ill patients.
  
  
  METHODS
  Sixty ventilated patients admitted for septic shock and acute lung injury were prospectively studied using simultaneously transesophageal echocardiography and pulmonary artery catheterization. Initial PCWP values and their changes measured invasively were compared to initial values and corresponding changes of early diastolic velocity of mitral annulus displacement measured by Doppler tissue imaging (Ea), flow propagation velocity of early diastolic mitral inflow measured by color M-mode Doppler (Vp), and their respective ratio to early mitral inflow velocity (E) measured by conventional Doppler: E/Ea and E/Vp. Relations between E/Ea, E/Vp, and PCWP were prospectively tested in 20 additional patients.
  
  
  RESULTS
  E/Ea and E/Vp gave a rough estimate of initial PCWP values with mean biases of 0.4 +/- 2.2 and 0.1 +/- 2.9 mmHg, respectively. Receiving operating characteristic curves demonstrated that an E/Ea of 6 or greater is an accurate predictor of a PCWP of 13 mmHg or greater and that an E/Ea of 5.4 is a good predictor of a PCWP of 8 mmHg or less. Changes in PCWP were significantly correlated to changes in E/Ea (Rho = 0.84, P < 0.0001).
  
  
  CONCLUSIONS
  In patients with postoperative circulatory shock and acute lung injury, transesophageal echocardiography estimates noninvasively PCWP. However, echocardiographic estimation of PCWP may not be accurate enough for adjusting therapy.
authors.affiliation: Réanimation Chirurgicale Pierre Viars, Department of Anesthesiology, Hospital Pitié-Salpêtrière, University of Paris VI, Paris, France.
authors.forename: Bélaïd
authors.initials: B
authors.lastname: Bouhemad
authors.forename: Armelle
authors.initials: A
authors.lastname: Nicolas-Robin
authors.forename: Alain
authors.initials: A
authors.lastname: Benois
authors.forename: Sacha
authors.initials: S
authors.lastname: Lemaire
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Goarin
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Rouby
mesh_terms: D002406:Catheterization, Peripheral; D015150:Echocardiography, Doppler; D017548:Echocardiography, Transesophageal; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000503:physiopathology; D011183:Postoperative Complications / Q000000981:diagnostic imaging; D011446:Prospective Studies; D011651:Pulmonary Artery; D011652:Pulmonary Circulation; D011669:Pulmonary Wedge Pressure / Q000502:physiology*; D012044:Regression Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012772:Shock, Septic / Q000601:surgery*; D012773:Shock, Surgical / Q000000981:diagnostic imaging*; D013599:Systole; D016277:Ventricular Function, Left