Transporters/receptors in the anterior chamber: pathways to explore ocular drug delivery strategies.
Membrane transporters/receptors are involved in drug transport processes and play a key role in intestinal absorption, tissue distribution and elimination. Drug targeting to specific transporters and receptors using carrier-mediated absorption has immense clinical significance. Ocular drug delivery is a challenging task since it involves drug transport across various barriers in the eye. Specialised transport processes exist at these barriers, which control the entry of drugs and xenobiotics. Ocular drug therapy involving topical or systemic administration of drugs has various limitations. Transport processes in the eye have been targeted in an effort to increase ocular bioavailability of drugs following topical instillation. This review discusses various transport processes in the eye and drug delivery strategies utilising these transporters/receptors.
Dey
Surajit
S
Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 5005 Rockhill Road, Kansas City, Missouri 64110-2499, USA.
Anand
Banmeet S
BS
Patel
Jignesh
J
Mitra
Ashim K
AK
D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism / Q000502:physiology*; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D026901:Membrane Transport Proteins; D009883:Ophthalmic Solutions