Blood cardioplegia filtration.
The introduction of blood cardioplegia has been proven to limit ischaemia and reperfusion injury in cardiac surgery. But the presence of activated neutrophils in the capillary bed may cause further damage. Leukocyte filters have been shown to be very effective in reducing the leukocytes in blood cardioplegia to less than 10%. Leukocyte depletion of blood cardioplegia provides an excellent approach to minimizing myocardial injury, predominantly in high-risk cardiac surgery.
Martin
Juergen
J
Department of Cardiovascular Surgery, Albert-Ludwigs-University Medical Centre, Freiburg, Germany. Martin@ch11.ukl.uni-freiburg.de
Krause
Matthias
M
Benk
Christoph
C
Lutter
Georg
G
Siegenthaler
Michael
M
Beyersdorf
Friedhelm
F
D000818:Animals; D006348:Cardiac Surgical Procedures / Q000379:methods; D002314:Cardioplegic Solutions / Q000378:metabolism* / Q000627:therapeutic use; D005374:Filtration; D006801:Humans; D007937:Leukapheresis / Q000295:instrumentation* / Q000379:methods; D007962:Leukocytes / Q000166:cytology / Q000502:physiology; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control
D002314:Cardioplegic Solutions