Intrarenal artery injection of L-arginine inhibits spontaneous activity of renal afferent nerve fibers.
The purpose of this study was to determine the effect of intrarenal artery injection of L-arginine on multi- and single-unit spontaneous discharges of renal afferent nerve fibers in anesthetized rabbits. The results obtained are as follows: (1) intrarenal artery injection of L-arginine (0.05, 0.24, and 0.48 mmol/kg) decreased the renal afferent nerve activity (ARNA) in a dose-dependent manner with arterial pressure unchanged; (2) pretreatment with a nitric oxide synthase inhibitor L-NAME (N6-nitro-L-arginine methylester, 0.11 mmol/kg), completely abolished the effect of L-arginine; and (3) intrarenal artery injection of a nitric oxide donor SIN-1 (3-morpholinosydnonimine, 3.75 micromol/kg) also resulted in an inhibition of ARNA. The results suggest that intrarenal artery injection of NO precursor (L-arginine) and donor (SIN-1) can inhibit ARNA in anesthetized rabbits.
Ma
Hui-Juan
HJ
Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, PR China.
Liu
Yi-Xian
YX
Wu
Yu-Ming
YM
He
Rui-Rong
RR
D000818:Animals; D001120:Arginine / Q000008:administration & dosage / Q000494:pharmacology*; D003864:Depression, Chemical; D055724:Electrophysiological Phenomena; D005260:Female; D007269:Injections, Intra-Arterial; D007668:Kidney / Q000294:innervation*; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D012077:Renal Artery; D017833:Visceral Afferents / Q000502:physiology*
D001120:Arginine