RNA localization and its role in the spatially restricted protein synthesis.
RNA localization is an evolutionarily conserved phenomenon that occurs in uni- and multi-cellular animal and plant species. Localized RNA plays a role in the establishment of cell polarity and/or the determination of cell fate. In recent years, it became evident that the major function of RNA localization is the creation of a high concentration of proteins in specific cellular compartments. The movement of RNA involves interactions between targeting signals within the RNA molecule, cytoskeleton, and molecular motors. Translocating RNA must be translationally silent, and on-site translation at the destination site requires a de-repression mechanism. This is probably achieved by sequestering RNA and the regulators of translation within the multiprotein RNP complexes that co-translocate all the components to the ultimate destination within the cell.
Kloc
Małgorzata
M
Department of Molecular Genetics, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.
Biliński
Szczepan M
SM
D000818:Animals; D016764:Cell Polarity; D019143:Evolution, Molecular; D006801:Humans; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism; D014176:Protein Biosynthesis; D021382:Protein Sorting Signals; D012313:RNA / Q000032:analysis* / Q000502:physiology; D034443:RNA Transport; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D020409:Molecular Motor Proteins; D021382:Protein Sorting Signals; D012333:RNA, Messenger; D012313:RNA