Cell division.
In creating the mitotic spindle and the contractile ring, natural selection has engineered fascinating precision machines whose movements depend upon forces generated by ensembles of cytoskeletal proteins. These machines segregate chromosomes and divide the cell with high fidelity. Current research on the mechanisms and regulation of spindle morphogenesis, chromosome motility and cytokinesis emphasizes how ensembles of dynamic cytoskeletal polymers and multiple motors cooperate to generate the forces that guide the cell through mitosis and cytokinesis.
Scholey
Jonathan M
JM
Laboratory of Cell and Computational Biology, Center for Genetics and Development, University of California, Davis, California 95616, USA. jmscholey@ucdavis.edu
Brust-Mascher
Ingrid
I
Mogilner
Alex
A
D000818:Animals; D002455:Cell Division; D020090:Chromosome Segregation; D003599:Cytoskeleton / Q000378:metabolism*; D008938:Mitosis; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*
D020409:Molecular Motor Proteins