[Role of fibroblasts in bronchial asthma].
The major role of fibroblasts is maintaining integrity, solidity and form of lung tissue. This is achieved by producing a vest variety of extracellular matrix (ECM) components such as collagen, laminin, fibronectin, hyaluronic acid and proteoglycans. Remodeling in the airways as seen in asthma is largely a result of altered fibroblast behavior. Fibroblasts produces a variety of inflammatory cytokines, chemokines and surface molecules which are able to activate and attract that stimulate inflammatory reactions. This paper presents a review of the fibroblast behavior and their interaction in the ongoing inflammatory and remodeling processes of the airway in asthma. Further we discuss the influence of glucocorticoids and long-acting beta 2-agonists on fibroblast in relation to their beneficial clinical effects in asthma therapy.
Dziedziczko
Andrzej
A
Katedra i Klinika Alergologii i Chorób Wewnetrznych, Akademii Medycznej w Bydgoszczy.
Pałgan
Krzysztof
K
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000402:Airway Obstruction / Q000378:metabolism / Q000503:physiopathology; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D005109:Extracellular Matrix / Q000187:drug effects / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D018343:Receptors, Adrenergic, beta-2 / Q000187:drug effects
D000318:Adrenergic beta-Agonists; D018343:Receptors, Adrenergic, beta-2
Rola fibroblastów w astmie oskrzelowej.