title: Fibrosing mediastinitis with superior vena cava obstruction as the initial presentation of Langerhans' cell histiocytosis in a young child.
abstract: We present a 2-year-old girl with an unusual presentation of Langerhans' cell histiocytosis (LCH). Five months prior to admission to our hospital, she received IV steroids for bronchial obstruction. On admission, clinical signs of SVC obstruction were evident and a mediastinal mass was evident on the chest radiograph and MRI. Biopsy revealed fibrosing mediastinitis. Five months later, osteolysis was present on a skull radiograph. Surgical biopsy of the skull lesion revealed LCH. This case is unique because it demonstrates a rare initial manifestation of LCH that has not been previously reported. Furthermore, the primary, solitary mediastinal manifestation without calcifications was histologically interpreted as fibrosing mediastinitis, and the final diagnosis of LCH was only made after identifying the skull lesion.
authors.affiliation: Department of Paediatric Radiology, Institute of Radiodiagnostics, University of Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany. trusen@roentgen.uni-wuerzburg.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Trusen
authors.forename: Matthias
authors.initials: M
authors.lastname: Beissert
authors.forename: Helge
authors.initials: H
authors.lastname: Hebestreit
authors.forename: Alexander
authors.initials: A
authors.lastname: Marx
authors.forename: Kassa
authors.initials: K
authors.lastname: Darge
mesh_terms: D002675:Child, Preschool; D005260:Female; D005355:Fibrosis; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008480:Mediastinitis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D012886:Skull / Q000000981:diagnostic imaging; D013479:Superior Vena Cava Syndrome / Q000000981:diagnostic imaging / Q000209:etiology*