title: Expression of interleukin 6 in synovial tissues in patients with internal derangement of the temporomandibular joint.
abstract: Using an immunohistochemical technique, we examined synovial tissue from 46 temporomandibular joints (TMJ) with internal derangement in 44 patients. As controls, we examined synovial tissue specimens from 7 joints with habitual dislocation without pain. In synovial tissues from 21 of the 46 joints with internal derangement, interleukin 6 (IL-6) was expressed in the synovial lining cells and in the mononuclear cells infiltrating the periphery of the blood vessels. The density of IL-6-stained cells in specimens with internal derangement correlated significantly with the grade of joint effusion shown by magnetic resonance imaging (P=0.01, r=0.32).
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Kanazawa, Japan. jun-s@kanazawa-med.ac.jp
authors.forename: J
authors.initials: J
authors.lastname: Sato
authors.forename: N
authors.initials: N
authors.lastname: Segami
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: N
authors.initials: N
authors.lastname: Demura
authors.forename: H
authors.initials: H
authors.lastname: Yoshimura
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshitake
authors.forename: K
authors.initials: K
authors.lastname: Nishikawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001182:Arthroscopy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000032:analysis*; D004204:Joint Dislocations / Q000276:immunology* / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D008335:Mandibular Condyle / Q000473:pathology; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013582:Synovial Fluid / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology* / Q000473:pathology; D019224:Temporomandibular Joint Disc / Q000098:blood supply / Q000276:immunology* / Q000473:pathology
chemical_list: D015850:Interleukin-6