title: Hypotension and bradycardia in infants after the use of topical brimonidine and beta-blockers.
abstract: Brimonidine is a selective alpha-2 adrenergic agonist used to treat glaucoma. There have been several reports of central nervous system depression after its use in infants. We observed rapid-onset bradycardia and decreased blood pressure in addition to central nervous system depression in 2 infants who received concomitant topical brimonidine and beta-blockers.
authors.affiliation: Department of Ophthalmology, The Hospital for Sick Children, University of Toronto, Ontario, Canada.
authors.forename: Nils K
authors.initials: NK
authors.lastname: Mungan
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Wilson
authors.forename: Ken K
authors.initials: KK
authors.lastname: Nischal
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
authors.forename: Alex V
authors.initials: AV
authors.lastname: Levin
mesh_terms: D000287:Administration, Topical; D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage* / Q000009:adverse effects*; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000009:adverse effects*; D001919:Bradycardia / Q000139:chemically induced*; D000068438:Brimonidine Tartrate; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D007223:Infant; D007231:Infant, Newborn; D007429:Intraocular Pressure / Q000187:drug effects; D011810:Quinoxalines / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: D000316:Adrenergic alpha-Agonists; D000319:Adrenergic beta-Antagonists; D011810:Quinoxalines; D000068438:Brimonidine Tartrate