Changes in antigenic characteristics of erythrocytes and number metaphase chromosome in bone marrow cells after experimental and clinical bone marrow transplantation.
Transplantation of allogenic bone marrow from HLA-identical sibs to patients with acute and chronic leukemia receiving immunosuppressive therapy is associated with the appearance of erythrocytes simultaneously carrying donor and recipient antigenic markers: AB0 system, rhesus factor and its subtypes, M and N antigens. Integration of genes responsible for each antigen is realized independently presumably at the level of stem cell, which ensures long-term (>3 years) repopulation of these erythrocytes. Experiments on inbred mice showed that transplantation of allogenic bone marrow is associated with an increase of chromosome number in 39% bone marrow cells 4 days after transplantation, which indicate the possibility of integration of whole chromosomes.
Babaeva
A G
AG
Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow.
Kurilo
L F
LF
Zotikov
E A
EA
Belan
E I
EI
Poreshina
L P
LP
Yudina
N V
NV
D000818:Animals; D001854:Bone Marrow Cells / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D000939:Epitopes / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D006822:Hybrid Cells / Q000276:immunology / Q000648:ultrastructure; D007938:Leukemia / Q000276:immunology / Q000628:therapy; D008677:Metaphase / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA
D000939:Epitopes