Effects of early ethanol exposure on dendrite growth of cortical pyramidal neurons: inferences from a computational model.
A computational model has been used to infer rules governing dendritic growth of layer 2/3 associative pyramidal neurons in a rat model of foetal alcohol syndrome. Basal dendrites were studied in adult rats exposed to ethanol during the first postnatal week. Results suggest that ethanol exposure during early postnatal life affects mainly the branching of dendrites rather than their elongation.
Granato
Alberto
A
Department of Psychology, Catholic University, L.go A. Gemelli 1, 20123, Milan, Italy. agranato@rm.unicatt.it
Van Pelt
Jaap
J
D000367:Age Factors; D020268:Alcohol-Induced Disorders, Nervous System / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D000831:Animals, Newborn; D001710:Biotin / Q000031:analogs & derivatives*; D002454:Cell Differentiation / Q000187:drug effects* / Q000502:physiology; D048429:Cell Size / Q000187:drug effects / Q000502:physiology; D002540:Cerebral Cortex / Q000187:drug effects* / Q000254:growth & development* / Q000473:pathology; D003712:Dendrites / Q000187:drug effects / Q000473:pathology; D003911:Dextrans; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008607:Intellectual Disability / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D008959:Models, Neurological; D011247:Pregnancy; D017966:Pyramidal Cells / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D003911:Dextrans; C076397:biotinylated dextran amine; D000431:Ethanol; D001710:Biotin