Similar enzymes, different mechanisms: COX-1 and COX-2 enzymes in neurologic disease.
DeKosky
Steven T
ST
Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA. DeKoskyST@upmc.edu
D000818:Animals; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D008565:Membrane Proteins; D009422:Nervous System Diseases / Q000201:enzymology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*
D007527:Isoenzymes; D008565:Membrane Proteins; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases