title: Can mothers be trusted to give malaria treatment to their children at home?
abstract: Children with symptomatic malaria in Bissau were randomly assigned to treatment with chloroquine 25 mg base/kg given supervised at a health centre or unsupervised by the mothers at home. On day 7, a blood sample for drug analyses was drawn and the children were then followed once weekly for 5 weeks. The data were analysed on an intention to treat basis. No differences were seen in the outcome of treatment nor in the blood drug concentrations on day 7 between the two groups. Mothers in Bissau can be trusted to give adequate anti-malarial medication to their children at home.
authors.affiliation: Projecto de Saúde de Bandim, Bissau, Guinea-Bissau. pekofoed@dadlnet.dk
authors.forename: Poul-Erik
authors.initials: PE
authors.lastname: Kofoed
authors.forename: Francisco
authors.initials: F
authors.lastname: Lopez
authors.forename: Peter
authors.initials: P
authors.lastname: Aaby
authors.forename: Kathryn
authors.initials: K
authors.lastname: Hedegaard
authors.forename: Lars
authors.initials: L
authors.lastname: Rombo
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage*; D002648:Child; D002654:Child Care / Q000379:methods; D002675:Child, Preschool; D002738:Chloroquine / Q000008:administration & dosage*; D005260:Female; D006169:Guinea-Bissau; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007223:Infant; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D009035:Mothers; D011897:Random Allocation
chemical_list: D000962:Antimalarials; D002738:Chloroquine