Surface electromyographic recording of volitional activity: a technique to detect partial motor conduction block.
Partial motor conduction block, an electrophysiological hallmark of demyelination, helps to identify acquired demyelinating neuropathies but its electrophysiological detection can be difficult. We report a technique that may be helpful in this regard. Twenty-five patients with partial motor conduction block secondary to acquired demyelinating polyneuropathy (ADP), 7 with amyotrophic lateral sclerosis (ALS), 7 with stroke, and 11 control subjects, were studied. Amplitude of compound muscle action potentials was recorded after distal electrical (E) stimulation and for volitionally (V) induced responses in 82 muscles. Mean +/- SD V/E ratio was 12.3 +/- 6.6 for ADP patients, 58.1 +/- 17 for ALS patients, 11.4 +/- 9 for stroke patients, and 55.4 +/- 12.3 for controls. The V/E ratios for patients with partial motor conduction block and stroke were significantly reduced compared with ALS patients and healthy controls (P < 0.05). Surface electromyographic (EMG) recording for determination of the V/E ratio may be a useful technique for detection of a proximal conduction block if a central lesion or poor effort can be excluded. Further study of this novel technique is necessary.
Chaudhry
Vinay
V
Department of Neurology, Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 5072 A, Baltimore, Maryland, USA. vchaudh@jhmi.edu
Corse
Andrea
A
Skolasky
Richard L
RL
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D004558:Electric Stimulation; D004576:Electromyography / Q000379:methods*; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000175:diagnosis* / Q000503:physiopathology*; D020521:Stroke / Q000175:diagnosis / Q000503:physiopathology; D014836:Volition / Q000502:physiology