Interactions of amphiphilic calix[4]arene-based Solid Lipid Nanoparticles with bovine serum albumin.
The interaction of Solid Lipid Nanoparticles (SLN) based on amphiphilic calix[4]arene with one of the major circulatory protein, serum albumin, has been investigated by Photon Correlation Spectroscopy (PCS) and Atomic Force Microscopy (AFM). The carrier systems have shown the ability to interact with bovine serum albumin (BSA), which forms a capping layer up to 17nm in depth. AFM imaging revealed that the SLNs are protected by this layer against flattening on surfaces.
Gualbert
Jérôme
J
Institut de Biologie et Chimie des Protéines, CNRS-UMR 5086, 7 Passage du Vercors, Lyon F69367, France.
Shahgaldian
Patrick
P
Coleman
Anthony W
AW
D000327:Adsorption; D047250:Calixarenes; D016503:Drug Delivery Systems; D008055:Lipids / Q000008:administration & dosage* / Q000737:chemistry; D018625:Microscopy, Atomic Force; D010636:Phenols / Q000008:administration & dosage* / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*
D008055:Lipids; D010636:Phenols; C121325:calix(4)arene; D047250:Calixarenes; D012710:Serum Albumin, Bovine