Evaluation of bone mineral density in children with cerebral palsy.
In the present study, bone mineral density of 40 children with cerebral palsy (study group) and the effects of various risk factors on bone mineralization in these children were investigated by comparing with 40 age-matched healthy children (control group). Weight, height, skinfold thickness, body-mass index measurements, and serum levels of calcium, phosphorus, alkaline phosphatase and 25 OH vitamin D were not significantly different between the study and control groups (p>0.05). The mean bone mineral density value of the study group measured by dual-energy X-ray absorptiometry method at L2-L4 levels of lumbar vertebrae was significantly lower than that of the control group (p<0.05). When the patients in the study group were assessed with respect to ambulation status, pattern of involvement, calcium and energy intakes, and whether or not they had taken and/or were taking a regular physical therapy program, there was a significant difference only between the hemiplegic and tetraplegic patients (p<0.05), while there were no significant differences among the patients who were ambulant versus non-ambulant, who had sufficient versus insufficient calcium and energy intakes, and who did and did not take a regular physical therapy (p>0.05). Although the ambulatory status, quantity of calcium and energy intakes, and the presence or absence of a physical therapy program had no effects on bone mineral density values of the children with cerebral palsy in this study, the exact factors and mechanisms responsible for the reduced bone mineral density in children with cerebral palsy should be investigated in further large-scale studies considering the increased risk of pathological fractures in these patients.
Unay
Bülent
B
Department of Pediatrics, Gülhane Military Medical Academy, Ankara, Turkey.
Sarici
S Umit
SU
Vurucu
Sabahattin
S
Inanç
Neriman
N
Akin
Ridvan
R
Gökçay
Erdal
E
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D000886:Anthropometry; D015519:Bone Density; D002118:Calcium / Q000097:blood; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006429:Hemiplegia; D006801:Humans; D008297:Male; D010758:Phosphorus / Q000097:blood; D012307:Risk Factors
D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium