Severe intoxication after phenytoin infusion: a preventable pharmacogenetic adverse reaction.
Citerio
G
G
Dipartimento di Anestesia e Rianimazione, Azienda Ospedaliera San Gerardo dei Tintori, Monza, Italy. g.citerio@hsgerardo.org
Nobili
A
A
Airoldi
L
L
Pastorelli
R
R
Patruno
A
A
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D001932:Brain Neoplasms / Q000150:complications / Q000235:genetics / Q000601:surgery; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D065729:Cytochrome P-450 CYP2C9; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005910:Glioma / Q000235:genetics; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics; D008297:Male; D009837:Oligodendroglioma / Q000150:complications / Q000601:surgery; D010672:Phenytoin / Q000009:adverse effects / Q000493:pharmacokinetics / Q000506:poisoning* / Q000627:therapeutic use; D011110:Polymorphism, Genetic; D012640:Seizures / Q000188:drug therapy / Q000209:etiology
D000927:Anticonvulsants; D010672:Phenytoin; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases