title: Mitral valve surgery and maternal and fetal outcome in valvular heart disease.
abstract: OBJECTIVE
  To compare maternal and fetal outcomes in patients with non-operated valvular heart disease and patients who had surgery before or during pregnancy.
  
  
  METHODS
  The 308 women with valvular heart disease who delivered in this hospital in the last 8 years were divided into three groups. The 218 (70.7%) women in group 1 had no surgical intervention; the 42 (13.6%) women in group 2 underwent balloon mitral valvotomy during pregnancy; and the 48 (15.5%) women in group 3 had surgical intervention before pregnancy (35 had balloon mitral valvotomy, eight had mitral valve replacement, and five had mitral valve repair). Maternal and fetal outcomes were compared for these three groups.
  
  
  RESULTS
  The antenatal events differed significantly: 175 (80.3%), 40 (94.2%), and 46 (95.8%) patients in groups 1, 2 and 3, respectively, had uneventful pregnancies. In group 1, 14 (6.4%) patients had congestive heart failure (P>0.05) and 24 (11%) patients had cardiac arrhythmias, which was statistically significant. The rate of preterm deliveries did not differ significantly among the three groups. The groups did not differ in mean birth weight, mode of delivery, low birth weight, Apgar scores less than 8, stillbirths, neonatal death, or congenital anomalies.
  
  
  CONCLUSIONS
  Mitral valve surgery before or during pregnancy did not significantly improve maternal and fetal outcomes but decreased adverse events such as congestive heart failure and cardiac arrhythmias. It should be therefore performed only in selected cases.
authors.affiliation: Department of Obstetrics & Gynaecology and Biostatistics, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India. monikachawla@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Malhotra
authors.forename: J B
authors.initials: JB
authors.lastname: Sharma
authors.forename: P
authors.initials: P
authors.lastname: Arora
authors.forename: S
authors.initials: S
authors.lastname: Batra
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: R
authors.initials: R
authors.lastname: Arora
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000209:etiology; D002301:Cardiac Glycosides / Q000627:therapeutic use; D002404:Catheterization; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006350:Heart Valve Prosthesis; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008943:Mitral Valve / Q000601:surgery*; D008946:Mitral Valve Stenosis / Q000150:complications / Q000628:therapy*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000628:therapy*; D011256:Pregnancy Outcome; D011654:Pulmonary Edema / Q000209:etiology / Q000401:mortality; D012189:Retrospective Studies
chemical_list: D000925:Anticoagulants; D000959:Antihypertensive Agents; D002301:Cardiac Glycosides