title: [Eosinophilic granuloma of the temporal bone. Case report and literature review].
abstract: BACKGROUND
  Eosinophilic granuloma, Hand-Schüller-Christian disease an Letterer-Siwe disease are characterised by ideopathic proliferation of histiocytes producing focal or systemic manifestations. Definitive diagnosis of histiocytosis is made by histopathology including immunohistochemical detection of S-100 and CD1a antigens. In general these diseases are summarised under the term Langerhans-cell histiocytosis (LCH). The localised form of LCH, in which the disease is limited to bones, lymphatic nodes or the lung, is commonly referred to as eosinophilic granuloma. Surgical excision, radiotherapy and chemotherapy, either alone or in combination, are the main treatment options.
  
  
  METHODS
  We present the case of a nine-year old boy with an extended eosinophilic granuloma of left temporal bone. The patient was submitted to a chemotherapeutic protocol with glucocorticoids, vinblastine and etoposide. Until today a successful treatment and a complete remission for one year can be reported.
  
  
  CONCLUSIONS
  Unifocal eosinophilic granuloma is usually treated by local excision and low-dose irradiation. However treatment with the chemotherapeutic protocol offered an excellent alternative avoiding extensive surgical destruction of the temporal bone in this case.
authors.affiliation: Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie der Ruhr-Universität Bochum am St. Elisabeth Hospital Bochum.
authors.forename: M
authors.initials: M
authors.lastname: Hellmann
authors.forename: H
authors.initials: H
authors.lastname: Stein
authors.forename: J
authors.initials: J
authors.lastname: Ebmeyer
authors.forename: H
authors.initials: H
authors.lastname: Sudhoff
mesh_terms: D001706:Biopsy; D002648:Child; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004427:Ear Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D004803:Eosinophilic Granuloma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D005047:Etoposide / Q000008:administration & dosage; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010579:Petrous Bone / Q000473:pathology; D013701:Temporal Bone / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D005938:Glucocorticoids; D014747:Vinblastine; D005047:Etoposide
vernacular_title: Eosinophiles Granulom des Felsen- und Schläfenbeins. Fallbericht und Literaturübersicht.