title: The efficacy of bacitracin methylene disalicylate when fed in combination with narasin in the management of necrotic enteritis in broiler chickens.
abstract: The efficacy of bacitracin methylene disalicylate (BMD) in the management of necrotic enteritis (NE) when fed in combination with narasin was investigated in a floor-pen study of 2,000 broiler chickens using a Clostridium perfringens inoculum challenge model. Treatments consisted of 1) nonchallenged-nonmedicated; 2) challenged-nonmedicated; 3) challenged-narasin (70 ppm); 4) challenged-BMD (55 ppm); 5) challenged-narasin (70 ppm) + BMD (55 ppm). Medication was provided in the feed from Day 0 to trial termination on Day 41. C. perfringens challenge occurred from Day 14 to 16. BMD and narasin, fed alone and in combination, reduced (P < 0.05) mortality due to NE when compared to challenged-nonmedicated birds. NE lesion scores (Days 0 through 41) were lower among birds fed BMD and narasin, alone and in combination, compared to challenged-nonmedicated birds. Improvements in NE mortality and NE lesion scores were greatest for the BMD + narasin-medicated birds, followed by the BMD-alone, and then narasin-alone treated birds. BMD and narasin, alone and in combination, provided improvements (P < 0.05) in average daily gains over the entire study (Days 0 to 41). The results of this study demonstrate the effectiveness of BMD and narasin in the management of NE in broiler chickens.
authors.affiliation: Maple Leaf Foods Agresearch, Burford, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Brennan
authors.forename: J
authors.initials: J
authors.lastname: Skinner
authors.forename: D A
authors.initials: DA
authors.lastname: Barnum
authors.forename: J
authors.initials: J
authors.lastname: Wilson
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001414:Bacitracin / Q000008:administration & dosage*; D002645:Chickens; D003015:Clostridium Infections / Q000188:drug therapy / Q000401:mortality / Q000662:veterinary; D003016:Clostridium perfringens; D004751:Enteritis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D008297:Male; D009336:Necrosis; D011201:Poultry Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D011714:Pyrans / Q000008:administration & dosage*; D012459:Salicylates / Q000008:administration & dosage*; D015430:Weight Gain
chemical_list: D000900:Anti-Bacterial Agents; D011714:Pyrans; D012459:Salicylates; D001414:Bacitracin; C013612:narasin; C023400:bacitracin methylenedisalicylic acid