title: Biological and clinical heterogeneity of B-cell chronic lymphocytic leukemia.
abstract: B-cell chronic lymphoproliferative disorders have been recognized as a heterogeneous group of neoplastic diseases affecting the lymphoid system. They are frequently characterized by leukemic manifestations with peripheral blood and/or bone marrow involvement. B-cell chronic lymphocytic leukemia (B-CLL), a disease which is now accepted as derived from immunologicallycompetent antigen-activated B-cells, is the most common in the western countries. Although for several decades it was considered as a unique entity, a body of evidences is now emerging indicating the biological heterogeneity of B-CLL. Molecular and immunophenotypic data induce to consider two main subgroups of B-CLL exist at the cellular level: in fact, B-CLL cases can be divided into two categories according to IgV gene mutation status. One group develops from "memory" B-cells after antigenic stimulation in the germinal center of secondary follicles, displays mutated gene IgV and lacks CD38 expression; the second one derives from the so-called "naïve" antigen inexperienced B-cells, does not present IgV gene mutations and displays CD38 surface molecule. The two groups seem to be characterised by different clinical outcomes with the "mutated" group expected to have a more benign course than that arising from a "naïve" B-cell. Thus, the definition of the biological features of these different groups could be of help for clinicians in order to recognize patients needing more intensive therapeutic approaches.
authors.affiliation: Hematology and Oncology Unit, C.R.O.B. Regional Hospital, Rionero in Vulture, Italy. gdarena@altavista.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: D'Arena
authors.forename: Nicola
authors.initials: N
authors.lastname: Di Renzo
authors.forename: Maura
authors.initials: M
authors.lastname: Brugiatelli
authors.forename: Maria L
authors.initials: ML
authors.lastname: Vigliotti
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Keating
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000145:classification / Q000175:diagnosis / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D007135:Immunoglobulin Variable Region