Role of vasoactive mediators in the pathogenesis of Chagas' disease.
This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoactive peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.
Mukherjee
Shankar
S
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Huang
Huan
H
Weiss
Louis M
LM
Costa
Sylvia
S
Scharfstein
Julio
J
Tanowitz
Herbert B
HB
D000595:Amino Acid Sequence; D000818:Animals; D014355:Chagas Disease / Q000209:etiology* / Q000378:metabolism*; D006801:Humans; D007705:Kinins / Q000737:chemistry / Q000502:physiology*; D008969:Molecular Sequence Data
D007705:Kinins