[Inhibitory action of sensory transmission by inhalational anesthetics in the spinal cord].
This review article focuses on the suppression of sensory transmission by inhalational anesthetics at the spinal cord level. Volatile anesthetics (e.g. halothane and isoflurane) suppress neuronal responses evoked by both noxious and non-noxious stimuli. This suppression is mediated largely by activation of GABAA and glycine receptors systems in the spinal dorsal horn. Depression of spinal glutamate receptor systems is also probably involved. The analgesic action of nitrous oxide is produced by activation of supra-spinal descending inhibitory systems, not by direct action on the spinal cord. Activation of the descending inhibitory systems by nitrous oxide causes release of noradrenaline in the spinal dorsal horn, and activates alpha 2 adrenergic receptor systems, resulting in depression of neuronal responses evoked by noxious stimuli. GABAA and glycine receptor systems in the spinal dorsal horn are also important components of nitrous oxide anesthesia in depressing neuronal responses evoked by non-noxious stimuli. Although excitation or inhibition of GABAA, glycine, alpha 2 adrenergic and glutamate receptors systems is an important action of inhalational anesthetics, influence of inhalational anesthetics on interactions among these receptor systems has yet to be studied.
Yamauchi
Masanori
M
Department of Anesthesiology, Yale University School of Medicine, 06520-8051, USA.
Omote
Keiichi
K
Namiki
Akiyoshi
A
Collins
J G
JG
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D009475:Neurons, Afferent / Q000187:drug effects*; D009609:Nitrous Oxide / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects / Q000502:physiology; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology; D017470:Receptors, Glutamate / Q000187:drug effects / Q000502:physiology; D018009:Receptors, Glycine / Q000187:drug effects / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D018685:Anesthetics, Inhalation; D018341:Receptors, Adrenergic, alpha-2; D011963:Receptors, GABA-A; D017470:Receptors, Glutamate; D018009:Receptors, Glycine; D009609:Nitrous Oxide; D006221:Halothane; D009638:Norepinephrine