title: Synthesis and biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one, 7-hydroxy-4,5-dimethyl-2H-chromen-2-one and their some derivatives.
abstract: 7-Hydroxy-4-methyl-2H-chromen-2-one (2), 7-hydroxy-4,5-dimethyl-2H-chromen-2-one (15) and their some derivatives were synthesized for exploring selected biological screening. The compounds 9 and 13 had shown high degree of cytotoxic activity. Three compound 9, 10 and 13 showed high degree of bactericidal activity amongst the present series.
authors.affiliation: HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hassaan2@super.net.pk
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Zafar S
authors.initials: ZS
authors.lastname: Saify
authors.forename: Saeedan
authors.initials: S
authors.lastname: Begum
authors.forename: Fatima
authors.initials: F
authors.lastname: Noor
authors.forename: Muhammad Zarrar
authors.initials: MZ
authors.lastname: Khan
authors.forename: Safdar
authors.initials: S
authors.lastname: Hayat
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
authors.lastname: Atta-Ur-Rahman
authors.lastname: Zia-Ullah
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D001156:Artemia / Q000187:drug effects; D001578:Benzopyrans / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy
chemical_list: D000900:Anti-Bacterial Agents; D001578:Benzopyrans