Evolution of function in (beta/alpha)8-barrel enzymes.
The (beta/alpha)(8)-barrel is the most common fold in structurally characterized enzymes. Whether the functionally diverse enzymes that share this fold are the products of either divergent or convergent evolution (or both) is an unresolved question that will probably be answered as the sequence databases continue to expand. Recent work has examined natural, designed, and directed evolution of function in several superfamilies of (beta/alpha)(8)-barrel containing enzymes.
Gerlt
John A
JA
Department of Biochemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA. j-gertl@uiuc.edu
Raushel
Frank M
FM
D000818:Animals; D005075:Biological Evolution; D019020:Directed Molecular Evolution; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation
D004798:Enzymes