title: Hepatitis B virus-mediated changes of apolipoprotein mRNA abundance in cultured hepatoma cells.
abstract: An inverse correlation between hepatitis B virus (HBV) and steady-state levels of apolipoprotein AI and CIII mRNAs was observed in two hepatoma cell lines. Analysis of a third line containing an inducible viral genome implicated viral pregenomic RNA in apolipoprotein mRNA reduction. We conclude that HBV alters infected cells despite the absence of overt cytopathogenicity.
authors.affiliation: Jefferson Center for Biomedical Research and Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Doylestown, Pennsylvania, USA. pamela.norton@mail.tju.edu
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Norton
authors.forename: Qiaoke
authors.initials: Q
authors.lastname: Gong
authors.forename: Anand S
authors.initials: AS
authors.lastname: Mehta
authors.forename: Xuanyong
authors.initials: X
authors.lastname: Lu
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Block
mesh_terms: D016632:Apolipoprotein A-I / Q000235:genetics / Q000378:metabolism*; D001056:Apolipoproteins C / Q000235:genetics / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular; D006515:Hepatitis B virus / Q000472:pathogenicity*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D016632:Apolipoprotein A-I; D001056:Apolipoproteins C; D012333:RNA, Messenger; D012367:RNA, Viral