Novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron.
A novel gene, aac(3)-Ic, encoding an AAC(3)-I aminoglycoside 3-N-acetyltransferase, was identified on a gene cassette inserted into a Pseudomonas aeruginosa integron that also carries a bla(VIM-2) and a cmlA7 gene cassette. The aac(3)-Ic gene product is 59 and 57% identical to AAC(3)-Ia and AAC(3)-Ib, respectively, and confers resistance to gentamicin and sisomicin.
Riccio
Maria Letizia
ML
Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, I-53100 Siena, Italy.
Docquier
Jean-Denis
JD
Dell'Amico
Emanuela
E
Luzzaro
Francesco
F
Amicosante
Gianfranco
G
Rossolini
Gian Maria
GM
D000123:Acetyltransferases / Q000235:genetics*; D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D032023:Integrons; D008969:Molecular Sequence Data; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics
D000123:Acetyltransferases; C019681:aminoglycoside acetyltransferase; C425108:beta-lactamase bla(vim-2); D001618:beta-Lactamases