Human meiosis: model organisms address the maternal age effect.
Studies in Drosophila support the view that a failure of cohesion between sister chromatids may contribute to meiotic nondisjunction in humans. Moreover, the demonstration of a meiotic aneugen in mice provides important clues to the higher frequencies of nondisjunction observed in older women.
Hawley
R Scott
RS
Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA. rsh@stowers-institute.org
D024422:Aneugens / Q000378:metabolism; D000818:Animals; D002842:Chromatids / Q000502:physiology; D004330:Drosophila / Q000166:cytology; D006801:Humans; D008423:Maternal Age; D008540:Meiosis / Q000502:physiology*; D051379:Mice; D023421:Models, Animal; D009630:Nondisjunction, Genetic
D024422:Aneugens