title: Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people.
abstract: We studied 82 non-demented old people and, using MRI, derived measures of grey and white matter and intracranial volumes. Controlling for sex and intracranial volume, we related grey and white matter volumes to plasma concentrations of vitamins C, B(12), folate, homocysteine, cholesterol, triglycerides, high density and low density (LDL) lipoproteins, and to red blood cell folate and glycated haemoglobin concentrations (HbA1(c)). We found that lower grey matter volume was associated with lower plasma vitamin C and higher homocysteine, cholesterol and LDL. Lower blood cell folate was also associated with lower grey matter volume but HbA1(c) was not. These data are consistent with the putative benefits of dietary vitamin C and folate intake and the role of cholesterol in age related neurodegeneration.
authors.affiliation: Clinical Research Centre, Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, UK. l.j.whalley@abdn.ac.uk
authors.forename: L J
authors.initials: LJ
authors.lastname: Whalley
authors.forename: R T
authors.initials: RT
authors.lastname: Staff
authors.forename: A D
authors.initials: AD
authors.lastname: Murray
authors.forename: S J
authors.initials: SJ
authors.lastname: Duthie
authors.forename: A R
authors.initials: AR
authors.lastname: Collins
authors.forename: H A
authors.initials: HA
authors.lastname: Lemmon
authors.forename: J M
authors.initials: JM
authors.lastname: Starr
authors.forename: I J
authors.initials: IJ
authors.lastname: Deary
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001205:Ascorbic Acid / Q000097:blood*; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000473:pathology*; D002784:Cholesterol / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D012737:Sex Factors
chemical_list: D006710:Homocysteine; D002784:Cholesterol; D001205:Ascorbic Acid