Determination of absolute structure of macroviracins by chemical synthesis.
The relative and absolute configurations of macroviracins have been established by the stereocontrolled synthesis of methyl ester 2a of the C(22) carboxylic acid, a constitutive fatty acid of macroviracin A (1), and their comparison to a sample 2 derived from the natural product 1. [structure: see text]
Takahashi
Shunya
S
RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama 351-0198, Japan. shunyat@postman.riken.go.jp
Hosoya
Moritoshi
M
Koshino
Hiroyuki
H
Nakata
Tadashi
T
D005227:Fatty Acids / Q000138:chemical synthesis / Q000737:chemistry*; D046911:Macromolecular Substances; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry
D005227:Fatty Acids; D046911:Macromolecular Substances; D009844:Oligosaccharides; C476171:macroviracin A