Demonstration of RANTES and eosinophilic cataionic protein in otitis media with effusion with allergy.
Regulated upon activation, normal T cell-expressed and -secreted (RANTES) is a chemokine which is an effective eosinophil and memory T cell chemoattractant and activator, and eosinophil is an important effector cell in allergic disease. It may contribute to the pathogenesis of otitis media with effusion (OME). Eosinophil cataionic protein (ECP), one of the major components of basic granules of eosinophils which is identified in middle ear effusion (MEE). We measured RANTES and ECP in MEEs of OME to determine whether RANTES is increased in the MEEs of OME with allergy. We also evaluated the correlation between RANTES and ECP to determine the role of RANTES as an eosinophil activator in the pathogenesis in OME with allergy. Both RANTES and ECP in MEE of OME with allergy were significantly higher than controls. There was a significant correlation between the contents of RANTES and ECP. Our results suggest the allergic role of chemokine in the pathogenesis of OME.
Jang
Chul Ho
CH
Department of Otolaryngology, Wonkwang Medical School, Iksan 570-711, South Korea. chul@wonkwang.ac.kr
Kim
Young Ho
YH
D001798:Blood Proteins / Q000378:metabolism*; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D004432:Ear, Middle / Q000276:immunology* / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D004804:Eosinophils / Q000378:metabolism*; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D010034:Otitis Media with Effusion / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D011852:Radioallergosorbent Test
D001798:Blood Proteins; D018946:Chemokine CCL5