title: Report of eight children with amitraz intoxication.
abstract: Many pesticides are formulated in organic solvents. An example is amitraz, one of the formamidine groups of pesticidal chemicals. It is commonly used for the treatment of generalized demodicosis in dogs and for the control of ticks and mites in cattle and sheep. In this article, the clinical and laboratory findings of eight children with amitraz intoxication are reviewed. The purpose was to enlighten the findings of amitraz intoxication in children. Of the eight patients, five (62.5%) were boys, three (37.5%) were girls, and the ages ranged from 1 to 4 years. All children accidentally ingested amitraz orally, with no dermal exposure. The most common observed signs were decreased consciousness and bradycardia. Leukocytosis, hyperglycemia, hypernatremia, increased serum aspartate transaminase level, and prolonged partial prothrombin time were diagnosed in children. None of the children had hypothermia, hypotension, or convulsion and none of the patients died. The findings show that the initial signs and symptoms of acute amitraz intoxication appeared severe but they disappeared, with only supportive care needed in most cases within a few days.
authors.affiliation: Yüzüncü Yil University, Faculty of Medicine, Department of Pediatrics, 65300, Van, Turkey. huseyincaksen@hotmail.com
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Caksen
authors.forename: Dursun
authors.initials: D
authors.lastname: Odabaş
authors.forename: Sükrü
authors.initials: S
authors.lastname: Arslan
authors.forename: Cihangir
authors.initials: C
authors.lastname: Akgün
authors.forename: Bülent
authors.initials: B
authors.lastname: Ataş
authors.forename: Sinan
authors.initials: S
authors.lastname: Akbayram
authors.forename: Oğuz
authors.initials: O
authors.lastname: Tuncer
mesh_terms: D001219:Aspartate Aminotransferases / Q000097:blood; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D001919:Bradycardia / Q000139:chemically induced; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced; D006955:Hypernatremia / Q000139:chemically induced; D007223:Infant; D007306:Insecticides / Q000506:poisoning*; D007964:Leukocytosis / Q000139:chemically induced; D008297:Male; D011041:Poisoning / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D011517:Prothrombin Time; D014052:Toluidines / Q000506:poisoning*; D014474:Unconsciousness / Q000139:chemically induced
chemical_list: D007306:Insecticides; D014052:Toluidines; C014983:amitraz; D001219:Aspartate Aminotransferases