title: Elastin polymorphism haplotype and intracranial aneurysms are not associated in Central Europe.
abstract: OBJECTIVE
  The occurrence of intracranial aneurysms and of aneurysmal subarachnoid hemorrhage are influenced by genetic factors. Recent genomic studies in Japan have defined 3 chromosomal loci and 1 haplotype of elastin polymorphisms as important risk factors, both for affected sib pairs and sporadic patients.
  
  
  METHODS
  We have genotyped 2 single nucleotide polymorphisms in the elastin gene and evaluated their allelic association with intracranial aneurysm in a Central European sample of 30 familial and 175 sporadic patients and 235 population controls.
  
  
  RESULTS
  We found no allelic association between this elastin polymorphism haplotype and intracranial aneurysm.
  
  
  CONCLUSIONS
  Our data probably reflect increased genetic heterogeneity of intracranial aneurysm in Europe compared with Japan.
authors.affiliation: Department of Neurology, Johann Wolfgang Goethe-University Frankfurt am Main, Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Hofer
authors.forename: Marcella
authors.initials: M
authors.lastname: Hermans
authors.forename: Nina
authors.initials: N
authors.lastname: Kubassek
authors.forename: Matthias
authors.initials: M
authors.lastname: Sitzer
authors.forename: Harald
authors.initials: H
authors.lastname: Funke
authors.forename: Florian
authors.initials: F
authors.lastname: Stögbauer
authors.forename: Vytautas
authors.initials: V
authors.lastname: Ivaskevicius
authors.forename: Johannes
authors.initials: J
authors.lastname: Oldenburg
authors.forename: Johannes
authors.initials: J
authors.lastname: Burtscher
authors.forename: Ulrich
authors.initials: U
authors.lastname: Knopp
authors.forename: Beate
authors.initials: B
authors.lastname: Schoch
authors.forename: Isabel
authors.initials: I
authors.lastname: Wanke
authors.forename: Felix
authors.initials: F
authors.lastname: Hübner
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Deinsberger
authors.forename: Bernhard
authors.initials: B
authors.lastname: Meyer
authors.forename: Hans
authors.initials: H
authors.lastname: Boecher-Schwarz
authors.forename: Werner
authors.initials: W
authors.lastname: Poewe
authors.forename: Andreas
authors.initials: A
authors.lastname: Raabe
authors.forename: Helmuth
authors.initials: H
authors.lastname: Steinmetz
authors.forename: Georg
authors.initials: G
authors.lastname: Auburger
mesh_terms: D000328:Adult; D017668:Age of Onset; D000483:Alleles; D017542:Aneurysm, Ruptured / Q000150:complications / Q000453:epidemiology*; D001317:Austria / Q000453:epidemiology; D002851:Chromatography, High Pressure Liquid; D004252:DNA Mutational Analysis; D004549:Elastin / Q000235:genetics*; D005260:Female; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D005858:Germany / Q000453:epidemiology; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D002532:Intracranial Aneurysm / Q000453:epidemiology / Q000235:genetics*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012422:Rupture, Spontaneous; D013345:Subarachnoid Hemorrhage / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*
chemical_list: D004549:Elastin