Prevalence of IL-1A and IL-1B polymorphisms in a Greek population.
OBJECTIVE
Given the possible ethnic diversity in distribution of genetic variants, aim of the present study was to estimate the prevalence of the polymorphisms of IL-1A+4845 and IL-1B+3954 in a Greek population of unknown periodontal status and to compare this prevalence with one from a group of patients with chronic (adult) periodontitis.


METHODS
110 healthy subjects of unknown periodontal status and 45 patients with chronic periodontitis were genotyped, using a PCR-based method and primers described in the literature. The differences in genotype, allele frequencies, allele carriage rate and presence of positive composite genotype as described by Kornman et al. (1997) were analyzed using Fisher's exact test and calculating two-sided p-value, odds ratios and confidence intervals.


RESULTS
No differences were observed in any of the parameters tested between the two groups.


CONCLUSIONS
Given the high prevalences of these polymorphisms observed in the general population,findings of the present study do not support a possible predictive value of the presence of allele 2 at IL-1A+4845 and IL-1B+3954 or the positive composite genotype for presence or absence of periodontal disease,in a Greek population.
Sakellari
Dimitra
D
Department of Periodontology, Preventive Dentistry and Implant Biology, Dental School, Aristotle University of Thessaloniki, Greece. dimisak@med.auth.gr
Koukoudetsos
Stavros
S
Arsenakis
Minas
M
Konstantinidis
Antonis
A
D000328:Adult; D000368:Aged; D000483:Alleles; D015415:Biomarkers / Q000032:analysis; D016009:Chi-Square Distribution; D002908:Chronic Disease; D016001:Confidence Intervals; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006115:Greece; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010518:Periodontitis / Q000235:genetics / Q000276:immunology; D010519:Periodontium / Q000276:immunology; D011110:Polymorphism, Genetic / Q000235:genetics*; D013223:Statistics as Topic
D015415:Biomarkers; D007375:Interleukin-1