Prenatal diagnosis by DNA polymorphism analysis of complete mole with coexisting twin.
Partial mole is distinguishable from complete mole with coexisting normal twin after delivery by DNA polymorphysm analysis. Our patient had chorionic villus sampling of a molar-appearing placenta with coexisting fetus at 12.3 weeks. Absent maternal alleles confirmed a diandrogenetic complete mole. Prenatal DNA diagnosis of complete mole is possible and clinically useful.
Wax
Joseph R
JR
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, USA.
Pinette
Michael G
MG
Chard
Renée
R
Blackstone
Jacquelyn
J
Do
Cartin
Angelina
A
D000328:Adult; D015193:Chorionic Villi Sampling; D004247:DNA / Q000235:genetics*; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000175:diagnosis* / Q000235:genetics; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011272:Pregnancy, Multiple; D011296:Prenatal Diagnosis / Q000379:methods; D014427:Twins; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000235:genetics*
D004247:DNA