An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics.
DNA gyrase is an essential topoisomerase found in all bacteria. It is encoded by gyrB and gyrA genes. These genes are organized differently in different bacteria. Direct comparison of Mycobacterium tuberculosis and Mycobacterium smegmatis genomes reveals presence of an additional gyrB in M. smegmatis flanked by novel genes. Analysis of the amino acid sequence of GyrB from different organisms suggests that the orphan GyrB in M. smegmatis may have an important cellular role.
Jain
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Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560 012, India. vraj@mcbl.iisc.ernet.in
Nagaraja
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V
D000595:Amino Acid Sequence; D027081:DNA Gyrase / Q000235:genetics*; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D020102:Mycobacterium smegmatis / Q000235:genetics*; D017422:Sequence Analysis, DNA
D027081:DNA Gyrase