No stirring necessary: parallel carbonylation of aryl halides with CO and various alcohols under pressure.
The parallel carbonylation of aryl halides with 6-25 bar of CO in 1-mL vials in a standard autoclave was investigated. 4-Bromoacetophenone and 2-chloropyridine were used as model substrates with 102 different O-nucleophiles (primary and secondary alcohols, phenols). No inertization during the loading was necessary. Fifty esters (43 new, yield up to 60%) were isolated and characterized. Ether, ester, ketone, and sometimes even olefin functions were usually tolerated. The new method is suitable for screening and small scale products synthesis.
Blaser
Hans-Ulrich
HU
Solvias AG, R-1055.6, CH-4002 Basel, Switzerland.
Diggelmann
Martin
M
Meier
Hans
H
Naud
Frédéric
F
Scheppach
Elke
E
Schnyder
Anita
A
Studer
Martin
M