Pharmacodynamics of isoflupredone acetate in an endotoxin-induced mastitis model.
The effect of intravenous administration of the steroidal drug isoflupredone acetate on lactating dairy cows with mastitis induced using gram-negative bacterial endotoxin was investigated. Cows were randomly assigned to one of four treatment groups: untreated controls, isoflupredone acetate only, mastitis only, and mastitis plus isoflupredone acetate. Isoflupredone acetate was given to treated groups at a dose of 20 mg intravenously, once. Mastitic cows receiving treatment were given isoflupredone acetate after the development of clinical signs. When compared with untreated mastitic controls, cows with endotoxin-induced mastitis treated with isoflupredone acetate did not exhibit measurable differences in heart rate, rectal temperature, rumen motility, or changes in mammary gland surface area in the 14 h following the administration of intramammary endotoxin. Healthy cows treated with isoflupredone acetate had a higher heart rate over the 14 h after drug administration than did untreated healthy controls. When compared with untreated mastitic controls, cows treated with isoflupredone acetate did not exhibit statistically significant differences in milk production following endotoxin-induced mastitis.
Wagner
S A
SA
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames 50011, USA. sawagner@iastate.edu
Apley
M D
MD
D000818:Animals; D001831:Body Temperature; D002417:Cattle; D004731:Endotoxins; D005260:Female; D005477:Fluprednisolone / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D006339:Heart Rate; D007700:Kinetics; D007774:Lactation; D008321:Mammary Glands, Animal / Q000473:pathology; D008414:Mastitis, Bovine / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D009119:Muscle Contraction; D012417:Rumen / Q000503:physiopathology
D004731:Endotoxins; C065592:isoflupredone acetate; D005477:Fluprednisolone