[Leptin and the feedback regulation of body weight].
Body weight may be controlled by a negative feedback loop. Recent studies have identified that the ob gene product, leptin, apparently and exclusively expressed in adipose tissue, is a part of the negative feedback loop. Leptin is proposed to act as an afferent signal in the negative feedback loop to hypothalamus that limiting food-intake, controlling energy homeostasis and regulating the mass of adipose tissue. The dificiency of or resistance to leptin causes severe obesity.
Wang
X
X
Institute of Child and Adolescent Health, Beijing Medical University, Beijing 100083, China.
Ye
G
G
Sun
J
J
D000818:Animals; D001835:Body Weight; D005246:Feedback; D006801:Humans; D020738:Leptin / Q000235:genetics / Q000502:physiology*; D009765:Obesity / Q000209:etiology; D011956:Receptors, Cell Surface / Q000378:metabolism; D054411:Receptors, Leptin
C515448:LEPR protein, human; D020738:Leptin; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin