Squamous cell carcinoma in recessive dystrophic epidermolysis bullosa, presenting as an ulcer that appears to be filled with granulation tissue.
BACKGROUND
Cutaneous squamous cell carcinoma (SCCA) is an important cause of death in patients with the severe form of recessive dystrophic epidermolysis bullosa (RDEB). These cancers often present with features that are different from those of actinically induced SCCA.


OBJECTIVE
To emphasize the unusual features with which SCCA can present in RDEB and discuss early recognition of such cancers.


METHODS
We present the case of a patient with RDEB who developed a cutaneous ulcer that appeared to be filled with heaped-up granulation tissue. Biopsy, however, showed moderately differentiated squamous cell carcinoma.


RESULTS
The patient underwent wide surgical excision of the cancer, with split-thickness skin graft. She has remained disease-free three years later.


CONCLUSIONS
In patients with RDEB, any ulcer that appears to be filled with heaped-up granulation tissue should be biopsied to rule out SCCA.
Kalisiak
Michal S
MS
Division of Dermatology and Cutaneous Sciences, University of Alberta, Edmonton, Alberta, Canada.
Edwards
David
D
Lin
Andrew N
AN
D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D016108:Epidermolysis Bullosa Dystrophica / Q000150:complications*; D005260:Female; D006097:Granulation Tissue / Q000473:pathology / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery