[Effect of lipid peroxidation on the spontaneous aggregation of thrombocytes in patients with stomach cancer in the early post-operative period].
The influence of intraoperative radiotherapy (IORT) on peroxidation of lipids (LP) and spontaneous aggregation of thrombocytes (SAT), which is regarded as a factor of risk for thrombogenic complications, has been investigated. Blood-serum concentration of spontaneous malonic deladehyde (MA) was used for LP assay. Blood antioxidative capacity was estimated versus MA increase taking place in the presence of ascorbic acid and ions of iron. SAT was measured microscopically with the aid of fixing thrombocytic aggregates with formalin. The procedure was employed to examine patients with stomach cancer. Some patients received standard surgery, the rest--surgery plus IORT. Increased LP and thrombocyte counts were reported after surgery in both groups. IORT was shown to trigger on activation of the antioxidant component of LP. It is suggested that early thrombocyte-related complications can be avoided after surgery if IORT is supplemented with enhanced antioxidant therapy.
Afanac'eva
A N
AN
Research Institute of Oncology, Research Center, Russian Academy of Medical Sciences, Siberian Branch, Tomsk.
Udut
V V
VV
Zyrianov
B N
BN
D005743:Gastrectomy; D006801:Humans; D015227:Lipid Peroxidation; D010974:Platelet Aggregation; D011184:Postoperative Period; D013274:Stomach Neoplasms / Q000097:blood* / Q000601:surgery*
Vliianie perekisnogo okisleniia lipidov na spontannuiu agregatsiiu trombotsitov u bol'nykh rakom zheludka v rannem posleoperatsionnom periode.