title: Isoxazole-based derivatives from Baylis-Hillman chemistry: assessment of preliminary hypolipidemic activity.
abstract: The synthesis of isoxazole-based derivatives utilizing Baylis-Hillman chemistry and results of their preliminary bioevaluation as hypolipidemic agents in triton model are described.
authors.affiliation: Medicinal Chemistry Division, Central Drug Research Institute, PO Box, 173, Lucknow 226001, India.
authors.forename: A
authors.initials: A
authors.lastname: Patra
authors.forename: S
authors.initials: S
authors.lastname: Batra
authors.forename: A P
authors.initials: AP
authors.lastname: Bhaduri
authors.forename: A
authors.initials: A
authors.lastname: Khanna
authors.forename: R
authors.initials: R
authors.lastname: Chander
authors.forename: M
authors.initials: M
authors.lastname: Dikshit
mesh_terms: D000080:Acetals / Q000737:chemistry; D000178:Acrylamides / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D000818:Animals; D020650:Combinatorial Chemistry Techniques; D029744:Commiphora; D004353:Drug Evaluation, Preclinical; D005343:Fibrinolytic Agents / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use; D053149:Plant Gums; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000080:Acetals; D000178:Acrylamides; D000577:Amides; D005343:Fibrinolytic Agents; D000960:Hypolipidemic Agents; D007555:Isoxazoles; D008055:Lipids; D010936:Plant Extracts; D053149:Plant Gums; C018562:guggulu extract