Cancer chemopreventive activity of acridone alkaloids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Seventeen acridone alkaloids isolated from the Rutaceous plants were tested for their inhibitory activities against Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. Some prenylated acridones were found to have remarkably potent activities. 1,3-Dihydroxy-10-methyl-2,4-diprenylacridone (18) as synthesized according to these results in vitro, exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The result of the present investigation indicated that some of these acridone alkaloids may be potentially valuable cancer chemopreventive agents.
Itoigawa
Masataka
M
Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan. itoigawa@tokaigakuen-u.ac.jp
Ito
Chihiro
C
Wu
Tian-Shung
TS
Enjo
Fumio
F
Tokuda
Harukuni
H
Nishino
Hoyoku
H
Furukawa
Hiroshi
H
D000166:Acridines / Q000494:pharmacology*; D054831:Acridones; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001681:Biological Assay; D002273:Carcinogens; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D008956:Models, Chemical; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate; D013997:Time Factors
D000166:Acridines; D054831:Acridones; D000470:Alkaloids; D016588:Anticarcinogenic Agents; D002273:Carcinogens; C041300:acridone; D013755:Tetradecanoylphorbol Acetate