title: Role of lipid-mediated signal transduction in bacterial internalization.
abstract: Receptor-mediated phagocytosis normally represents an important first line of immune defence. Invading microbes are internalized into phagosomes and are typically killed by exposure to a battery of microbicidal agents. To some intracellular pathogens, however, receptor-mediated phagocytosis represents an opportunity to access a protected niche within the host cell. Another type of intracellular pathogen, including Salmonella enterica serovar Typhimurium and Shigella flexneri, invade host cells in a more direct manner. These pathogens deliver effectors into the host cell via a type III secretion apparatus, initiating a ruffling response that leads to their uptake into intracellular vacuoles. Recent studies have demonstrated the importance of lipid signal transduction events in the uptake of pathogenic bacteria by both receptor-mediated phagocytosis and type III secretion-mediated invasion. In this review we highlight some of these discoveries, with a focus on phospholipid-dependent signalling events.
authors.affiliation: Infection, Immunity, Injury and Repair, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.
authors.forename: John H
authors.initials: JH
authors.lastname: Brumell
authors.forename: Sergio
authors.initials: S
authors.lastname: Grinstein
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism* / Q000472:pathogenicity*; D006801:Humans; D050356:Lipid Metabolism; D021962:Membrane Microdomains / Q000378:metabolism; D008954:Models, Biological; D010587:Phagocytosis; D010588:Phagosomes / Q000378:metabolism / Q000382:microbiology; D010716:Phosphatidylinositols / Q000378:metabolism; D015398:Signal Transduction; D014617:Vacuoles / Q000378:metabolism / Q000382:microbiology; D014774:Virulence / Q000502:physiology
chemical_list: D010716:Phosphatidylinositols