title: Effects of air pollution on adults with chronic obstructive pulmonary disease.
abstract: Few studies have been conducted on the effects of air pollution on patients with chronic obstructive pulmonary disease (COPD). During a 14-mo period, 39 Parisian adults with severe COPD were monitored by their physicians. Daily levels of 4 air pollutants were provided by an urban air-quality network. Exacerbation of COPD was associated only with ozone (O3) (odds ratio [OR] = 1.44 for a 10-microg/m3 increase in O3; 95% confidence interval [CI] = 1.14, 1.82), with a lag of 2-3 days. The effect of O3 was greater in patients whose carbon dioxide pressure (PaCO2) was higher than 43 mm Hg (OR = 1.83; 95% CI = 1.36, 2.47) vs. those with a lower PaCO2 (OR = 1.26; 95% CI = 0.90, 1.77). The effect of O3 was unchanged, regardless of the maintenance medications used. The only air pollutant to which patients with severe COPD were particularly sensitive was O3.
authors.affiliation: Laboratoire d'Hygiène et de Santé Publique, Faculté de Pharmacie, Université René Descartes, Paris, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Desqueyroux
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Pujet
authors.forename: Michel
authors.initials: M
authors.lastname: Prosper
authors.forename: Yvon
authors.initials: Y
authors.lastname: Le Moullec
authors.forename: Isabelle
authors.initials: I
authors.lastname: Momas
mesh_terms: D000368:Aged; D000393:Air Pollutants / Q000032:analysis*; D000397:Air Pollution / Q000032:analysis / Q000706:statistics & numerical data*; D002248:Carbon Monoxide / Q000032:analysis; D018450:Disease Progression; D004784:Environmental Monitoring / Q000706:statistics & numerical data*; D062665:Epidemiological Monitoring; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006813:Humidity; D008297:Male; D008875:Middle Aged; D009585:Nitrogen Dioxide / Q000032:analysis; D010126:Ozone / Q000032:analysis; D029424:Pulmonary Disease, Chronic Obstructive / Q000145:classification / Q000453:epidemiology*; D012621:Seasons; D013458:Sulfur Dioxide / Q000032:analysis; D013696:Temperature
chemical_list: D000393:Air Pollutants; D013458:Sulfur Dioxide; D010126:Ozone; D002248:Carbon Monoxide; D009585:Nitrogen Dioxide