title: Chromosomal distribution of the human cardiovascular transcriptome.
abstract: On the basis of previous observations in chromosomes 21 and 22, we hypothesize that there is a tissue-specific organization of cardiovascular gene transcripts in the human genome. To examine the distribution of heart-derived transcripts, we assigned a nonredundant set of 4628 fetal and 3574 adult known and uncharacterized cardiovascular expressed-sequence tags (cvESTs) to 5-Mb chromosomal 'windows' on the basis of publicly available sequence mapping data. On a whole-genome level (36,617 genes), chromosome 17 (19.2% in fetal, 16.5% in adult) contained the highest proportion of cvESTs, whereas chromosome Y (2.0% in fetal and adult) contained the lowest. In total, 50 of the 639 windows contained a significantly higher proportion of cvESTs (P < 0.003) compared with the genome-wide cvEST gene density, particularly on gene-dense chromosomes (that is, 17, 19, 22) as opposed to gene-rich chromosomes (for example, 1, 2, 11). This report provides insight into a possible role for complex tissue-specific gene regulation in the human genome.
authors.affiliation: The Cardiovascular Genome Unit, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Thorn 1334, Boston, MA 02115, USA.
authors.forename: J David
authors.initials: JD
authors.lastname: Barrans
authors.forename: James
authors.initials: J
authors.lastname: Ip
authors.forename: Ching-Wan
authors.initials: CW
authors.lastname: Lam
authors.forename: Irene L
authors.initials: IL
authors.lastname: Hwang
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Dzau
authors.forename: Choong-Chin
authors.initials: CC
authors.lastname: Liew
mesh_terms: D002319:Cardiovascular System / Q000378:metabolism*; D002874:Chromosome Mapping; D018076:DNA, Complementary; D030561:Databases, Nucleic Acid; D020224:Expressed Sequence Tags; D020869:Gene Expression Profiling; D006801:Humans
chemical_list: D018076:DNA, Complementary