title: [Chronic inflammatory demyelinating polyneuropathy].
abstract: Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated disease of the peripheral nervous system with a prevalence of 1-2/100,000. Clinical and experimental findings suggest a role of immune pathomechanisms;however, the target antigens are still unknown. Beside classic CIDP with symmetrical proximal and distal paresis, subgroups of CIDP with pure motor or sensory deficits have been described. Diagnostic criteria include evidence of demyelination in electrophysiological examination and biopsy as well as elevated protein content in the CSF. Magnetic resonance imaging of plexuses and roots extends the diagnostic armamentarium and may be helpful in differential diagnosis. The utility of immunosuppressant/immunomodulatory therapies has been demonstrated in several studies.
authors.affiliation: Neurologische Klinik, Universitätsklinikum Düsseldorf, Düsseldorf. koellerh@uni-duesseldorf.de
authors.forename: H
authors.initials: H
authors.lastname: Köller
authors.forename: B C
authors.initials: BC
authors.lastname: Kieseier
authors.forename: S
authors.initials: S
authors.lastname: Jander
authors.forename: H-P
authors.initials: HP
authors.lastname: Hartung
mesh_terms: D001324:Autoantigens / Q000276:immunology; D001706:Biopsy; D003937:Diagnosis, Differential; D004568:Electrodiagnosis; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009413:Nerve Fibers, Myelinated / Q000276:immunology / Q000473:pathology; D009460:Neurologic Examination; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D013497:Sural Nerve / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D001324:Autoantigens
vernacular_title: Chronisch inflammatorische demyelinisierende Polyneuropathie.