[New perspectives of the mechanism of action of antidepressants arised from genomic theory of depression].
Depression is a highly prevalent condition in adult population. Research on the mechanism of action of antidepressant drugs is also expected to allow a better comprehension about its etiopathogenesis. First theories about neurobiology of depression pointed out the monoaminergic modifications elicited by antidepressants. However, these changes could not be correlated with the latency of action observed in their clinical use. In 1997, with the formulation of genomic theory of depression, old theories and new knowledge about cellular and molecular effects of antidepressant treatment became congruent. The main goal of this paper is to review this theory and the scientific papers in which it is supported. Scientific evidences against genomic theory of antidepressant action are also mentioned. CREB's participation in antidepressant response, as well as BDNF trophic effect and their intracellular signaling pathways are described, as many of these molecules could become targets for the action of new antidepressants.
Cereseto
M
M
CONICET, Buenos Aires, Argentina. mcereset@ffyb.uba.ar
Ferrero
A
A
D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D015220:Calcium Channels / Q000187:drug effects; D000242:Cyclic AMP / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects
D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D015220:Calcium Channels; D017362:Cyclic AMP Response Element-Binding Protein; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases
El mecanismo de acción de los antidepresivos a la luz de la teoría genómica de la depresión.