title: Epstein-Barr virus-associated peripheral T-Cell lymphoma involving spleen in a renal transplant patient.
abstract: The incidence of posttransplantation lymphoproliferative disorders (PTLDs) has increased in recent years. Although rare, various types of T-cell lymphoma have been reported and their association with Epstein-Barr virus (EBV) has been compared with B-cell PTLDs. We report a case of splenic peripheral T-cell lymphoma occurring in a 47-yr-old male patient 7 yr after renal allograft transplantation. The spleen showed sinusoidal proliferation of focal CD30 positive, large, atypical lymphoid cells. Positivity for CD3 and cytolytic granule-associated proteins was also demonstrated in the tumor cells, while anaplastic large cell lymphoma kinase (ALK) and CD8 were not expressed. Strong nuclear signals for EBV mRNA were noted by EBER1 in situ hybridization. A molecular genetic study demonstrated a rearrangement of the gamma T-cell receptor gene. To our knowledge, this case is unique in terms of a posttransplant T-cell lymphoma that shows focal CD30, cytolytic granule-associated proteins, and EBV positivity.
authors.affiliation: Department of Pathology, Daejon St. Mary's Hosptial, Catholic University College of Medicine, Daejon, Korea. apw01@hanmail.net
authors.forename: Hye Kyung
authors.initials: HK
authors.lastname: Lee
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Lee
authors.forename: Suk Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Tae In
authors.initials: TI
authors.lastname: Park
authors.forename: Chang Suk
authors.initials: CS
authors.lastname: Kang
authors.forename: Woo Ick
authors.initials: WI
authors.lastname: Yang
mesh_terms: D053804:Granzymes; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D017730:Ki-1 Antigen / Q000235:genetics / Q000378:metabolism; D016030:Kidney Transplantation; D016411:Lymphoma, T-Cell, Peripheral / Q000473:pathology / Q000821:virology*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008875:Middle Aged; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D012367:RNA, Viral; D016601:RNA-Binding Proteins / Q000378:metabolism; D012697:Serine Endopeptidases / Q000378:metabolism; D013160:Splenic Neoplasms / Q000473:pathology / Q000821:virology*; D000074019:T-Cell Intracellular Antigen-1
chemical_list: C099537:Epstein-Barr virus encoded RNA 1; D017730:Ki-1 Antigen; D008565:Membrane Proteins; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human; C509213:GZMB protein, human; D053804:Granzymes; D012697:Serine Endopeptidases