BRCA proteins and DNA damage checkpoints.
BRCA1 and BRCA2 are frequently mutated in breast cancer patients, responsible for the majority cases of familial breast cancer. Through genetic and biochemical analysis, the function of BRCA1 and BRCA2 is emerging. This review examines recent progresses in understanding the roles of BRCA proteins in DNA damage checkpoint control and how they are regulated in response to DNA damage
Lou
Zhenkun
Z
Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Chen
Junjie
J
D000818:Animals; D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D002453:Cell Cycle / Q000502:physiology*; D004249:DNA Damage / Q000235:genetics*; D006801:Humans; D010766:Phosphorylation
D019313:BRCA1 Protein; D024682:BRCA2 Protein