Body and brain development following exposure to 60Co gamma-irradiation during pregnancy in mice.
We studied the dose-response effects of gamma-irradiation on the weight gains of the body and the brain in ICR mice exposed to various doses of 60Co gamma-irradiation ranging from 0 to 1.5 Gy on day 13 of pregnancy (El3). We found that 0.5 Gy gamma-irradiation caused a significant reduction in brain weight but not in body weight among 6-week-old mice. Higher doses (1.0, 1.5 Gy) seriously inhibited body and brain development, resulting in significantly low weights at 6 weeks of age. A significantly lower brain weight among fetuses exposed to 1.5 Gy was found as early as 24 hours after exposure, while significant reductions in the body weight of these same fetuses appeared 3 days after exposure. The effects of radiation on brain and body development were similar for both males and females.
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Department of Teratology and Genetics, Division of Molecular and Cellular Adaptation, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Inouye
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Hayasaka
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Yamamura
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D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001835:Body Weight / Q000528:radiation effects*; D001921:Brain / Q000254:growth & development* / Q000473:pathology / Q000528:radiation effects*; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005314:Embryonic and Fetal Development / Q000528:radiation effects*; D005260:Female; D005720:Gamma Rays; D008297:Male; D018811:Maternal Exposure; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000528:radiation effects; D011247:Pregnancy; D011270:Pregnancy, Animal; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes