title: Bolus-chasing contrast-enhanced 3D MRA of the lower extremity. Comparison with intraarterial DSA.
abstract: OBJECTIVE
  To evaluate step-table 3D contrast-enhanced (CE) MRA with bolus chasing for the detection and grading of stenoses in patients with peripheral vascular disease (PVD) of the lower extremities.
  
  
  METHODS
  Fifty patients were studied by step-table bolus-chasing 3D-CE-MRA and i.a. DSA within 24 h. After determination of the individual circulation time, CE-MRA was performed during power injection of 40 ml of Gd-DTPA. To cover the whole range between the renal arteries and the feet with three slab locations, the scanner table was manually advanced twice for 350 mm. Total imaging time was 1 min 23 s. The degree of stenosis and image quality of the images were evaluated by 2 observers. In addition, a treatment plan was established based on the 3D-CE-MRA and DSA investigations.
  
  
  RESULTS
  In 44 of 50 patients (88%), the visualization of the arterial tree from the renal arteries to the foot was possible. Forty-six of 50 patients (92%) had good or very good image quality. In the calf, 3D-CE-MRA was superior to DSA in 6 patients. For the detection of stenosis >50%, sensitivity was 99.5%, specificity 98.8%, positive predictive value 95.6% and the negative predictive value 99.8%. Cohen's kappa for 3D-CE-MRA vs. DSA was 0.926; for interobserver agreement it was 0.96.
  
  
  CONCLUSIONS
  Bolus-chasing 3D-CE-MRA with manual table movement is a simple, robust and easy to perform technique which provides high quality angiograms of the lower extremity arterial system and is comparable to, i.a., DSA for the diagnosis of PVD.
authors.affiliation: Department of Diagnostic Radiology, Christian-Albrechts-Universität Kiel, Kiel, Germany.
authors.forename: J C
authors.initials: JC
authors.lastname: Steffens
authors.forename: F K W
authors.initials: FK
authors.lastname: Schäfer
authors.forename: B
authors.initials: B
authors.lastname: Oberscheid
authors.forename: J
authors.initials: J
authors.lastname: Link
authors.forename: T
authors.initials: T
authors.lastname: Jahnke
authors.forename: M
authors.initials: M
authors.lastname: Heller
authors.forename: J
authors.initials: J
authors.lastname: Brossmann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply* / Q000000981:diagnostic imaging*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011859:Radiography
chemical_list: D003287:Contrast Media