Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein.
The Leptin protein is central to the regulation of energy metabolism in mammals. By integrating evolutionary, structural, and biochemical information, a surface segment, outside of its known receptor contacts, is predicted as a second interaction site that may help to further define its roles in energy balance and its functional differences between humans and other mammals.
Gaucher
Eric A
EA
NASA Astrobiology Institute and Foundation for Applied Molecular Evolution, University of Florida, Gainesville, Florida, 32611-7200, USA. gaucher@ufl.edu
Miyamoto
Michael M
MM
Benner
Steven A
SA
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D019143:Evolution, Molecular; D006801:Humans; D020738:Leptin / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D010802:Phylogeny; D017434:Protein Structure, Tertiary
D020738:Leptin