title: [Studies of the specificity of immediate allergic reactions to ampicillin].
abstract: Ampicillin belongs to the drugs causing most frequently IgE-dependent allergic reactions, but the current specificity of these reactions is poorly known. Some experimental data suggest that the side chain of ampicillin may induce synthesis of drug-specific IgE antibodies. In our study we have decided to explain the specificity of ampicillin-induced allergic reactions type I appearing in patients after drug administration. Thirty-eight subjects developing an immediate response after administration of ampicillin entered the study. In all the patients skin tests with penicillin, ampicillin and amoxicillin determinants were performed. We have observed positive skin tests results with penicillin determinants in 23 subjects, in 32 subjects with ampicillin and in 17 cases with amoxicillin. Only in three persons the results were positive exclusively to ampicillin. The results of our study indicate that in the Polish population ampicillin induces an immediate IgE response with variable degree of cross-reactivity to other tested drugs, and selective response to ampicillin is uncommon.
authors.affiliation: Katedra i Klinika Chorób Wewnetrznych i Alergologii, Akademii Medycznej we Wrocławiu.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Medrala
authors.forename: Anna
authors.initials: A
authors.lastname: Wolańczyk-Medrala
authors.forename: Irena
authors.initials: I
authors.lastname: Kustrzeba-Wójcicka
authors.forename: Jerzy
authors.initials: J
authors.lastname: Liebhart
authors.forename: Wioletta
authors.initials: W
authors.lastname: Szczepaniak
authors.forename: Robert
authors.initials: R
authors.lastname: Sycz
authors.forename: Tomasz
authors.initials: T
authors.lastname: Tomkowicz
authors.forename: Józef
authors.initials: J
authors.lastname: Małolepszy
mesh_terms: D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000276:immunology; D000667:Ampicillin / Q000009:adverse effects / Q000276:immunology*; D016022:Case-Control Studies; D003429:Cross Reactions; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced* / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000009:adverse effects / Q000276:immunology*; D011852:Radioallergosorbent Test; D012680:Sensitivity and Specificity; D012882:Skin Tests
chemical_list: D010406:Penicillins; D007073:Immunoglobulin E; D000667:Ampicillin; D000658:Amoxicillin
vernacular_title: Badania nad swoistościa natychmiastowych reakcji alergicznych wywoływanych przez ampicyline.