title: Malignant solitary fibrous tumor of the pleura: report of a case with cytogenetic analysis.
abstract: The majority of solitary fibrous tumors (SFTs) of the pleura are benign, but 10-30% locally recur or metastasize. Pathogenic factors relevant to the determinism of their biological properties are largely unknown. Cytogenetic data on SFTs of the pleura are sparse. We report herein a case of a malignant SFT of the pleura where successful karyotyping was obtained from the primary and recurrent tumors. The initial karyotype showed two abnormal clones: 48, XY; +8; +8; del(9)(q22; q32) [19] and 46, XY, t(1;16)(q25;p12) [7]. Culture of the recurrent tumor yielded one clone identical to the dominant clone of the initial karyotype. Demonstration of a recurrent abnormal karyotype largely supports its relevance to the malignant clone and suggests a role of supernumerary chromosome(s) 8 in the determinism of malignant behavior in SFT.
authors.affiliation: Department of Pathology, C.H.U. Sart-Tilman, Tour de Pathologie, B23, +1, 4000, Liège, Belgium. L.deLeval@ulg.ac.be
authors.forename: Laurence
authors.initials: L
authors.lastname: de Leval
authors.forename: Jean-Olivier
authors.initials: JO
authors.lastname: Defraigne
authors.forename: Gilberte
authors.initials: G
authors.lastname: Hermans
authors.forename: Florence
authors.initials: F
authors.lastname: Dôme
authors.forename: Jacques
authors.initials: J
authors.lastname: Boniver
authors.forename: Christian
authors.initials: C
authors.lastname: Herens
mesh_terms: D000782:Aneuploidy; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002898:Chromosomes, Human, Pair 8; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018218:Neoplasms, Fibrous Tissue / Q000235:genetics / Q000556:secondary* / Q000601:surgery; D010997:Pleural Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D011796:Quinacrine; D014178:Translocation, Genetic
chemical_list: D011796:Quinacrine