[Serum sex hormone and urinary metabolites of male workers exposed to carbon disulfide].
Serum luteotropic hormone(LH), follicle-stimulating hormone (FSH), prolectin(PRL) and testosterone (T) were determined by radioimmunoassay methods in 50 workers exposed to carbon disulfide(CS2) in a viscose rayon factory. Urinary excretion of 2-thio-thiazolidine-4-carboxilic acid (TTCA) in workers by the end of work shift was analyzed with modified high-performance liquid chromatography. The working conditions of the factory had not been changed since 1950s. The concentration of CS2, determined by Multigas Monitor (type 1320) in workplace, was (14.4 +/- 4.62) mg/m3. The results showed that: (1) serum FSH of CS2 group (10.04 +/- 7.35)IU/L was significantly higher than that of control group (7.50 +/- 7.07 IU/L), PRL of CS2 group (5.72 +/- 4.18) ng/L was significantly lower than that of control group (6.89 +/- 4.64 ng/L). Serum LH was declined with the increase of time exposed to CS2, (2) urinary TTCA in CS2 group was 1.072 +/- 1.013 mg/g Cr. Serum FSH was declined with the increase of TTCA excretion. The results suggested that the function of endocrine system was disturbed in workers exposed to CS2.
Wang
C
C
Dept. of Hygiene, Hubei Medical University, Wuhan 430071, China.
Bi
Y
Y
Tan
X
X
Yan
J
J
D000328:Adult; D002246:Carbon Disulfide / Q000009:adverse effects*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D016273:Occupational Exposure; D011388:Prolactin / Q000097:blood; D013739:Testosterone / Q000097:blood; D013844:Thiazoles / Q000652:urine*; D053778:Thiazolidines
D012739:Gonadal Steroid Hormones; D013844:Thiazoles; D053778:Thiazolidines; C031677:2-thioxo-4-thiazolidinecarboxylic acid; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002246:Carbon Disulfide