title: The callipyge locus: evidence for the trans interaction of reciprocally imprinted genes.
abstract: The callipyge phenotype in sheep is an inherited muscular hypertrophy that affects only heterozygous individuals who receive the CLPG mutation from their father. The CLPG mutation is a single nucleotide substitution in what is probably a long-range control element (LRCE) within the DLK1-GTL2 imprinted domain. Recent results suggest that the unique mode of inheritance of callipyge, referred to as polar overdominance, results from the combination of the cis-effect of the CLPG mutation on the expression levels of genes in the DLK1-GTL2 imprinted domain, and the trans interaction between the products of reciprocally imprinted genes.
authors.affiliation: Department of Genetics, Faculty of Veterinary Medicine, University of Liège (B43), 20 Bd de Colonster, 4000-Liège, Belgium. michel.georges@ulg.ac.be
authors.forename: Michel
authors.initials: M
authors.lastname: Georges
authors.forename: Carole
authors.initials: C
authors.lastname: Charlier
authors.forename: Noelle
authors.initials: N
authors.lastname: Cockett
mesh_terms: D000818:Animals; D005799:Genes, Dominant; D018392:Genomic Imprinting; D006023:Glycoproteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D006984:Hypertrophy; D018482:Muscle, Skeletal / Q000473:pathology*; D009135:Muscular Diseases / Q000235:genetics / Q000662:veterinary*; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D062085:RNA, Long Noncoding; D012756:Sheep; D012757:Sheep Diseases / Q000235:genetics*
chemical_list: D006023:Glycoproteins; C498907:MEG3 non-coding RNA, human; D011506:Proteins; D062085:RNA, Long Noncoding