Synthesis and biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one, 7-hydroxy-4,5-dimethyl-2H-chromen-2-one and their some derivatives.
7-Hydroxy-4-methyl-2H-chromen-2-one (2), 7-hydroxy-4,5-dimethyl-2H-chromen-2-one (15) and their some derivatives were synthesized for exploring selected biological screening. The compounds 9 and 13 had shown high degree of cytotoxic activity. Three compound 9, 10 and 13 showed high degree of bactericidal activity amongst the present series.
Khan
Khalid Mohammed
KM
HEJ Research Institute of Chemistry, International Centre for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hassaan2@super.net.pk
Saify
Zafar S
ZS
Begum
Saeedan
S
Noor
Fatima
F
Khan
Muhammad Zarrar
MZ
Hayat
Safdar
S
Choudhary
M Iqbal
MI
Perveen
Shahnaz
S
Atta-Ur-Rahman
Zia-Ullah
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D001156:Artemia / Q000187:drug effects; D001578:Benzopyrans / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy
D000900:Anti-Bacterial Agents; D001578:Benzopyrans