Role of prophylactic intravitreal antibiotics in open globe injuries.
OBJECTIVE
To determine the efficacy of prophylactic intravitreal antibiotics in reducing the incidence of endophthalmitis after trauma.


METHODS
This was a prospective, randomised, case control study of 70 consecutive patients with open globe injury. The patients were prospectively randomised into group I (32 eyes) and group II (38 eyes). Group I patients were given prophylactic intravitreal injection of vancomycin 1 mg and ceftazidime 2.25 mg at the conclusion of primary repair. Group II patients were not given prophylactic intravitreal antibiotics. All the patients received intravenous ciprofloxacin.


RESULTS
The incidence of endophthalmitis was higher in group II (7 of 38 eyes; 18.42%) compared to group I (2 of 32 eyes; 6.25%). Both the patients who developed endophthalmitis despite prophylactic intravitreal antibiotics in group I had an initially undetected intraocular foreign body (eyelash) in the vitreous cavity.


CONCLUSIONS
Prophylactic intravitreal broad spectrum antibiotic injection decreases the risk of post-traumatic endophthalmitis.
Narang
Subina
S
Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Gupta
Vishali
V
Gupta
Amod
A
Dogra
Mangat R
MR
Pandav
Surinder S
SS
Das
Sayan
S
D000293:Adolescent; D000328:Adult; D019072:Antibiotic Prophylaxis / Q000379:methods*; D002442:Ceftazidime / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D009877:Endophthalmitis / Q000517:prevention & control*; D015807:Eye Injuries, Penetrating / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014640:Vancomycin / Q000627:therapeutic use*; D014821:Vitrectomy / Q000379:methods; D014822:Vitreous Body / Q000187:drug effects
D014640:Vancomycin; D002442:Ceftazidime