title: Burkholderia is highly resistant to human Beta-defensin 3.
abstract: The bactericidal activity of the novel beta-defensin hBD-3 against 28 species and 55 strains of gram-positive cocci and gram-negative fermentative and nonfermentative rods was tested. All strains proved to be highly or intermediately susceptible to hBD-3 (minimal bactericidal concentration [MBC], </=50 micro g/ml), except for Burkholderia cepacia, for all 23 tested strains of which MBCs were >100 micro g/ml.
authors.affiliation: Department of Medical Microbiology, Clinical Research Unit, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany. sahly@medmicrobio.unikiel.de
authors.forename: Hany
authors.initials: H
authors.lastname: Sahly
authors.forename: Sabine
authors.initials: S
authors.lastname: Schubert
authors.forename: Jürgen
authors.initials: J
authors.lastname: Harder
authors.forename: Peter
authors.initials: P
authors.lastname: Rautenberg
authors.forename: Uwe
authors.initials: U
authors.lastname: Ullmann
authors.forename: Jens
authors.initials: J
authors.lastname: Schröder
authors.forename: Rainer
authors.initials: R
authors.lastname: Podschun
mesh_terms: D019117:Burkholderia / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D023083:beta-Defensins / Q000494:pharmacology*
chemical_list: C422950:DEFB103A protein, human; D023083:beta-Defensins