Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis.
The cysteine proteinases CPA and CPB from Leishmania major induced Th1 responses in patients with leishmaniasis due to Leishmania guyanensis. Furthermore, cysteine proteinases induced neither interleukin 4 (IL-4) nor IL-13 and low levels of IL-10 in controls and patients. The results suggest that CPs would be quite good candidates for a vaccine against different Leishmania species.
Pascalis
Hervé
H
Immunologie des Leishmanioses, Institut Pasteur de le Guyane Française, Institut d'Etudes Supérieures de la Guyane, Université Antilles-Guyane, Cayenne, French Guiana.
Lavergne
Anne
A
Bourreau
Eliane
E
Prévot-Linguet
Ghislaine
G
Kariminia
Amina
A
Pradinaud
Roger
R
Rafati
Sima
S
Launois
Pascal
P
D000818:Animals; D000953:Antigens, Protozoan; D001483:Base Sequence; D003546:Cysteine Endopeptidases / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D018334:Leishmania guyanensis / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000276:immunology*; D008969:Molecular Sequence Data; D015800:Protozoan Proteins / Q000276:immunology*; D016052:Protozoan Vaccines / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology*
D000953:Antigens, Protozoan; D007376:Interleukin-2; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; C093139:LACK antigen, Leishmania; D015847:Interleukin-4; D007371:Interferon-gamma; D003546:Cysteine Endopeptidases