Chemoenzymatic synthesis of neuraminic acid containing C-glycoside polymers.
[structure: see text] Two neuraminic acid-based, C-glycoside polymers were synthesized. Preliminary studies on one of these polymers showed potent neuraminidase inhibitory activity, suggesting potential utility as an antipathogenic surface coating for the preparation of antimicrobial biomaterials.
Wang
Qun
Q
Division of Medicinal and Natural Products Chemistry and Department of Chemical and Biochemical Engineering, The University of Iowa, Iowa City, Iowa 52242, USA.
Dordick
Jonathan S
JS
Linhardt
Robert J
RJ
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D003016:Clostridium perfringens / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006027:Glycosides / Q000138:chemical synthesis*; D006735:Horseradish Peroxidase / Q000737:chemistry / Q000378:metabolism; D009438:Neuraminic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D009439:Neuraminidase / Q000037:antagonists & inhibitors; D009195:Peroxidase / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000138:chemical synthesis*; D013025:Glycine max
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D006027:Glycosides; D009438:Neuraminic Acids; D011108:Polymers; D006735:Horseradish Peroxidase; D009195:Peroxidase; D009439:Neuraminidase