Effects of antireflux treatment on bronchial hyper-responsiveness and lung function in asthmatic patients with gastroesophageal reflux disease.
OBJECTIVE
To investigate the effects of antireflux treatment on bronchial hyper-responsiveness and lung function in asthmatic patients with gastroesophageal reflux disease (GERD).


METHODS
Thirty asthmatic patients with GERD were randomly divided into two groups (group A and group B). Patients in group A (n=15) only received asthma medication including inhaled salbutamol 200 microg four times a day and budesonide 400 microg twice a day for 6 weeks. Patients in Group B (n=15) received the same medication as group A, and also antireflux therapy including oral omeprazole 20 mg once a day and domperidone 10 mg three times a day for 6 weeks. Pulmonary function tests and histamine bronchoprovocation test were performed before and after the study.


RESULTS
There was no significant difference in the baseline values of pulmonary function and histamine PC(20-FEV1) between the two groups. At the end of the study, the mean values for VC, VC%, FVC, FVC%, FEV(1), FEV(1)%, PEF, PEF%, PC(20-FEV1) were all significantly improved in group B, compared with group A.


CONCLUSIONS
Antireflux therapy may improve pulmonary function and inhibit bronchial hyper-responsiveness in asthmatic patients with GERD.
Jiang
Shan-Ping
SP
Department of Respiratory Medicine, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China. zengzhiyong99@hotmail.com
Liang
Rui-Yun
RY
Zeng
Zhi-Yong
ZY
Liu
Qi-Liang
QL
Liang
Yong-Kang
YK
Li
Jian-Guo
JG
D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D004294:Domperidone / Q000627:therapeutic use; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use; D054328:Proton Pump Inhibitors
D054328:Proton Pump Inhibitors; D004294:Domperidone; D009853:Omeprazole