[Effect of chlorimethylmercury on the expression of c-fos and c-jun genes in rat brain].
To study the role of immediate early genes (IEG) c-fos and c-jun in the neurotoxic mechanism of methylmercury chloride(MMC), expression of FOS and JUN in rat brains was observed by using immunohistochemical methods. In the test group MMC (5.0 mg/kg and 0.1 mg/kg) was injected into rats while in the control group normal saline was injected. The results showed that after rats exposed for 3 hours, the expression of FOS and JUN in brains was higher than those of the control rats, the results indicated that IEG could participate in the neurological toxicity induced by chlorimethylmercury.
Cheng
Jinping
J
School of Environmental Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China.
Wang
Wenhua
W
Jia
Jinping
J
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D016762:Genes, fos / Q000187:drug effects*; D016758:Genes, jun / Q000187:drug effects*; D008297:Male; D008767:Methylmercury Compounds / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D008767:Methylmercury Compounds; C004925:methylmercuric chloride