Involvement of cholecystokinin/gastrin-related peptides and their receptors in clinical gastrointestinal disorders.
In this paper the possible roles of cholecystokinin (CCK), gastrin, or gastrin-related peptides and their receptors in human gastrointestinal diseases are reviewed. For CCK/CCK(A) receptors (CCK(A)-R), the evidence for their proposed involvement in diseases caused by impaired CCK release or CCK(A)-R mutations, pancreatic disorders (acute/chronic pancreatitis), gastrointestinal motility disorders (gallbladder disease, irritable bowel syndrome), pancreatic tumor growth and satiety disorders, is briefly reviewed. The evidence that has established the involvement of gastrin/CCK(B)-R in mediating the action of hypergastrinaemic disorders, mediating hypergastrinaemic effects on the gastric mucosa (ECL hyperplasia, carcinoids, parietal cell mass), and acid-peptic diseases, is reviewed. The evidence for their possible involvement in mediating growth of gastric and pancreatic tumours and possible involvement of gastrin-related peptides in colon cancers, is reviewed briefly.
Jensen
Robert T
RT
Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1804, USA. robertj@bdg10.niddk.nih.gov
D000818:Animals; D002766:Cholecystokinin / Q000172:deficiency / Q000378:metabolism / Q000502:physiology; D005755:Gastrins / Q000378:metabolism / Q000502:physiology; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000502:physiology; D005770:Gastrointestinal Neoplasms / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D010190:Pancreatic Neoplasms / Q000209:etiology* / Q000378:metabolism; D011949:Receptors, Cholecystokinin / Q000172:deficiency / Q000378:metabolism / Q000502:physiology
D005755:Gastrins; D011949:Receptors, Cholecystokinin; D002766:Cholecystokinin