Image-based computational simulation of flow dynamics in a giant intracranial aneurysm.
OBJECTIVE
Blood flow dynamics are thought to play an important role in the pathogenesis and treatment of intracranial aneurysms; however, hemodynamic quantities of interest are difficult to measure in vivo. This study shows that computational fluid dynamics (CFD) combined with computed rotational angiography can provide such hemodynamic information in a patient-specific and prospective manner.


METHODS
A 58-year-old woman presented with partial right IIIrd cranial nerve palsy due to a giant carotid-posterior communicating artery aneurysm that was subsequently coiled. Computed rotational angiography provided high resolution volumetric image data from which the lumen geometry was extracted. This and a representative flow rate waveform were provided as boundary conditions for finite element CFD simulation of the 3D pulsatile velocity field.


RESULTS
CFD analysis revealed high speed flow entering the aneurysm at the proximal and distal ends of the neck, promoting the formation of both persistent and transient vortices within the aneurysm sac. This produced dynamic patterns of elevated and oscillatory wall shear stresses distal to the neck and along the sidewalls of the aneurysm. These hemodynamic features were consistent with patterns of contrast agent wash-in during cine angiography and with the configuration of coil compaction observed at 6-month follow-up.


CONCLUSIONS
Anatomic realism of lumen geometry and flow pulsatility is essential for elucidating the patient-specific nature of aneurysm hemodynamics. Such image-based CFD analysis may be used to provide key hemodynamic information for prospective studies of aneurysm growth and rupture or to predict the response of an individual aneurysm to therapeutic options.
Steinman
David A
DA
Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Canada.
Milner
Jaques S
JS
Norley
Chris J
CJ
Lownie
Stephen P
SP
Holdsworth
David W
DW
D001783:Blood Flow Velocity / Q000502:physiology; D002533:Cerebral Angiography / Q000379:methods*; D003198:Computer Simulation; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008432:Mathematical Computing; D008875:Middle Aged; D011379:Prognosis; D011673:Pulsatile Flow / Q000502:physiology; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*