Nitric oxide metabolities in acute rheumatic fever.
Acute rheumatic fever (ARF), is a systemic inflammatory disease etiologically related to infection with group A beta hemolytic streptococcus, characterized by a broad spectrum of disorders in cellular immunity. To estimate the activity of the immunopathological process in patients with ARF, plasma nitric oxide metabolities (NOx) concentrations, IL-1alpha and IL-2 levels were investigated in 22 patients with ARF at the time on admission, and after 3 months, in children with chronic rheumatic heart disease (CRHD). Plasma NOx concentrations, IL-1alpha and IL/2 levels in patients with ARF on admission were significantly higher than in the same patients 3 months later, and higher than in CRHD, or controls. Increased plasma NO may be a useful index for the quantitative assessment of the activity during immunological challenge. This information may be useful for the prognosis and monitoring of ARF.
Narin
Figen
F
Department of Biochemistry, Erciyes University Medical Faculty, Kayseri, Turkey.
Narin
Nazmi
N
Pasaoğlu
Hatice
H
Halici
Canan
C
Aslan
Duran
D
D000208:Acute Disease; D000293:Adolescent; D000367:Age Factors; D002648:Child; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D008297:Male; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism*; D011379:Prognosis; D012213:Rheumatic Fever / Q000378:metabolism*; D013997:Time Factors
D007375:Interleukin-1; D007376:Interleukin-2; D009569:Nitric Oxide