title: [3-substituted analogs of remantadine: synthesis and antiherpetic activity in Vero cells].
abstract: Chemical synthesis of 3-substituted analogues of remantadine is described. Derivatives IIIb and IIIc when compared with remantadine had not only potent activity against ethalon herpes simplex type 1 virus strain but also were active against herpes virus resistant to aciclovir. Compound IIIc demonstrated virulecidal effect. Combination of IIIc + aciclovir had additive effect against ethalon herpes simplex type 1 virus strain. Investigated 3-substituted analogues demonstrated low activity in the model system of influenzae virus. No antiviral activity was demonstrated in the model system of Syndbys virus (though compounds were evaluated in subtoxic concentrations).
authors.affiliation: D. I. Ivanovsky Research Institure of Virology Russian Academy of Medical Sciences, Moscow.
authors.forename: I K
authors.initials: IK
authors.lastname: Moiseev
authors.forename: V L
authors.initials: VL
authors.lastname: Andronova
authors.forename: V V
authors.initials: VV
authors.lastname: Pozdniakov
authors.forename: N V
authors.initials: NV
authors.lastname: Makarova
authors.forename: G A
authors.initials: GA
authors.lastname: Galegov
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D012299:Rimantadine / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects*; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D012299:Rimantadine; D000212:Acyclovir
vernacular_title: 3-zameshchennye analogi remantadina: sintez i protivogerpeticheskaia aktivnost' v kul'ture kletok Vero.