title: Fertility after laparoscopic myomectomy of large uterine myomas: operative technique and preliminary results.
abstract: OBJECTIVE
  The purpose of this study was to evaluate indications and complications of laparoscopic myomectomy with regard to the reproductive outcome of infertile women with a large leiomyomatous uterus.
  
  
  METHODS
  From January 1997 to July 1999, 144 patients underwent laparoscopic myomectomy for a myoma measuring > or = 5 cm in diameter. Indications for surgery were increase in size of myoma in infertile patients (70.8%), pain (44.4%) or abnormal bleeding (68%). Average size of myomas were 7.8 cm with a range of 5 cm to 18 cm. The myomas were intramural/submucosal (n = 108), subserosal (n = 15), intraligamentous (n = 14) and peduncolated (n = 7). The laparotomy conversion rate was 1.39% (n = 2); one case required a blood transfusion. Operating time ranged from 58 to 180 minutes with an average of 95 minutes. Average hospital stay was 2.6 days and the overall complication rate was 2.08%. Eighteen patients (12.5%) underwent second-look laparoscopy. The rate of postoperative adhesion was 33.3%; there were no adnexal adhesions. In all cases ultrasonography was done one day after the operation and five weeks postoperatively to compare wound healing, the last control showed an irregular hypodense area in only 14 patients (9.7%).
  
  
  RESULTS
  Twenty-six patients operated on in 1997 went on to conceive: nine vaginal deliveries, 12 Caesarean sections, four miscarriages and one ectopic pregnancy. No uterine rupture was observed. The pregnancy rate for patients submitted to laparoscopic myomectomy in 1997 (n = 38) was 34.21% at six months (n = 13) and 55.26% (n = 21) at 12 months after the procedures.
  
  
  CONCLUSIONS
  Our preliminary results confirm that conception occurs in the majority of infertile women with a large leiomyomatous uterus who undergo myomectomy and second-look laparoscopy leads to a low complication rate.
authors.affiliation: Malzoni Medical Center "Villa dei Platani," Avellino, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Malzoni
authors.forename: M
authors.initials: M
authors.lastname: Rotond
authors.forename: C
authors.initials: C
authors.lastname: Perone
authors.forename: D
authors.initials: D
authors.lastname: Labriola
authors.forename: F
authors.initials: F
authors.lastname: Ammaturo
authors.forename: A
authors.initials: A
authors.lastname: Izzo
authors.forename: S
authors.initials: S
authors.lastname: Panariello
authors.forename: H
authors.initials: H
authors.lastname: Reich
mesh_terms: D000328:Adult; D015331:Cohort Studies; D019160:Endosonography; D005260:Female; D005298:Fertility; D005500:Follow-Up Studies; D006801:Humans; D015907:Hysteroscopy / Q000009:adverse effects / Q000379:methods*; D007247:Infertility, Female; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods; D007813:Laparotomy / Q000379:methods; D007889:Leiomyoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D011247:Pregnancy / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*