Enhancement patterns of prostate cancer in dynamic MRI.
Our objective was to analyze fast-field-echo dynamic subtracted (FFE/DS) MRI data in prostate cancer, in order to recognize enhancement patterns of tumoral tissue in comparison with non-tumoral peripheral prostatic tissue. Eleven consecutive patients with prostate cancer were proposed for radical prostatectomy. Before surgery, all patients underwent endorectal coil MRI examination. In addition to standard sequences, a dynamic study was performed by FFE/DS to evaluate tumoral behavior after Gd-DTPA rapid infusion. Analysis of the imaging was made by the means of the time/signal intensity curve obtained during early contrast medium enhancement, sampling both the abnormal enhancing focal area and the opposite lobe at the level of the main prostatic tissue. A focal area of increased enhancement was observed in the site of the tumor in all cases. The time/intensity curve sampled on this area and compared with the opposite lobe demonstrated a high confidence interval of the difference of the data: mean tumor maximal intensity 1331 (SD 187) vs normal 470 (SD 139) and mean tumor rise time 103 s (SD 30) vs normal 250 (SD 38; p<0.01). In tumoral tissue, the enhancement percentage of signal intensity (SI%=pre-contrast minus post-contrast/pre-contrast x100) was 316.7%. At FFE/DS, there is a typical behavior of the time/intensity curve of contrast enhancement in prostatic cancer that might be employed in diagnosis of the disease.
Preziosi
Paolo
P
Department of Radiology, AFaR-CRCCS, Fatebenefratelli Hospital, Isola Tiberina, 00186 Rome, Italy.
Orlacchio
Antonio
A
Di Giambattista
Guido
G
Di Renzi
Paolo
P
Bortolotti
Luigi
L
Fabiano
Alfredo
A
Cruciani
Enrico
E
Pasqualetti
Patrizio
P
D000368:Aged; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D011856:Radiographic Image Enhancement; D015203:Reproducibility of Results; D013223:Statistics as Topic
D003287:Contrast Media; D019786:Gadolinium DTPA