title: Hypertrophic pachymeningitis: case report.
abstract: Hypertrophic pachymeningits is an unusual cause of neurological symptoms and is often secondary to infections, carcinomatosis or inflammatory diseases. It may also be idiopathic. We report a case of pachymeningitis which was manifested primarily by psychosis and visual loss with optic atrophy and destruction of nasal septum. The patient, a 45 year old woman was submitted to extensive investigation without evidence of any underlying disease. A meningeal biopsy was performed and showed a mostly unspecific inflammatory process with extensive fibrosis of the dura and few early stage granulomas. These findings suggest either neurosarcoidosis or idiopathic hypertrophic pachymeningitis.
authors.affiliation: University of Campinas, Campinas, SP, Brazil.
authors.forename: Leonardo
authors.initials: L
authors.lastname: de Deus-Silva
authors.forename: Luciano de Souza
authors.initials: Lde S
authors.lastname: Queiroz
authors.forename: Verônica de Araújo
authors.initials: Vde A
authors.lastname: Zanardi Vd
authors.forename: Enrico
authors.initials: E
authors.lastname: Ghizoni
authors.forename: Hoyama da Costa
authors.initials: Hda C
authors.lastname: Pereira
authors.forename: George Linard Silva
authors.initials: GL
authors.lastname: Malveira
authors.forename: Clodoaldo
authors.initials: C
authors.lastname: Pirani
authors.forename: Benito Pereira
authors.initials: BP
authors.lastname: Damasceno
authors.forename: Fernando
authors.initials: F
authors.lastname: Cendes
mesh_terms: D001706:Biopsy; D004388:Dura Mater / Q000473:pathology; D005260:Female; D005682:Gadolinium; D006801:Humans; D006984:Hypertrophy; D018810:Magnetic Resonance Angiography; D008581:Meningitis / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D009300:Nasal Septum / Q000473:pathology; D009901:Optic Nerve Diseases / Q000150:complications
chemical_list: D005682:Gadolinium