title: Toward a realistic model of mutations affecting fitness.
abstract: Analysis of a recent mutation accumulation (MA) experiment has led to the suggestion that as many as one-half of spontaneous mutations in Arabidopsis are advantageous for fitness. We evaluate this in the light of data from other MA experiments, along with molecular evidence, that suggest the vast majority of new mutations are deleterious.
authors.affiliation: University of Edinburgh, Institute of Cell, Animal and Population Biology, West Mains Road, Edinburgh EH9 3JT, United Kingdom. p.keightley@ed.ac.uk
authors.forename: Peter D
authors.initials: PD
authors.lastname: Keightley
authors.forename: Michael
authors.initials: M
authors.lastname: Lynch
mesh_terms: D000818:Animals; D017360:Arabidopsis / Q000235:genetics* / Q000502:physiology; D005075:Biological Evolution; D008957:Models, Genetic; D009154:Mutation; D010641:Phenotype; D012098:Reproduction; D012641:Selection, Genetic