14-3-3 proteins in apoptosis.
The once obscure members of the 14-3-3 protein family play significant roles in the determination of cell fate. By inhibiting the pro-apoptotic BAD (Bcl-2-antagonist of cell death) and the transcription factor FKHRL-1, 14-3-3 displays important anti-apoptotic characteristics. To date, five points of interaction of 14-3-3 with the apoptotic machinery have been identified. How these interactions are regulated still remains a mystery.
Rosenquist
M
M
The Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden. magnus.rosenquist@genpat.uu.se
D048948:14-3-3 Proteins; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; D006801:Humans; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014446:Tyrosine 3-Monooxygenase / Q000502:physiology*
D048948:14-3-3 Proteins; D004268:DNA-Binding Proteins; C085126:FOXO1 protein, human; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; D019253:Proto-Oncogene Proteins c-bcl-2; D014157:Transcription Factors; D014446:Tyrosine 3-Monooxygenase