title: Nitrendipine-induced subacute cutaneous lupus erythematosus.
abstract: A 66-year-old man presented with widespread annular and bullous subacute cutaneous lupus erythematosus (SCLE), developed after starting treatment for hypertension with the calcium channel blocker nitrendipine. A few days after withdrawal of the drug, while cutaneous manifestations were improving, left hemiparesis occurred. Laboratory investigations showed, in addition to anti-Ro, anti-La and anti-histone antibodies, the presence of lupus anticoagulant, anticardiolipin antibodies, prolonged APTT and thrombocytopenia. On the basis of the spontaneous regression of the patient's skin lesions after discontinuation of the drug, a possible relationship between nitrendipine intake, the clinical events and the biological findings is discussed.
authors.affiliation: Institute of Dermatological Sciences of the University of Milan, Via Pace, Italy. mizzidoc@libero.it
authors.forename: Angelo V
authors.initials: AV
authors.lastname: Marzano
authors.forename: Alessandro
authors.initials: A
authors.lastname: Borghi
authors.forename: Maurizio
authors.initials: M
authors.lastname: Mercogliano
authors.forename: Maura
authors.initials: M
authors.lastname: Facchetti
authors.forename: Ruggero
authors.initials: R
authors.lastname: Caputo
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced* / Q000276:immunology*; D008297:Male; D009568:Nitrendipine / Q000009:adverse effects*; D010291:Paresis / Q000139:chemically induced
chemical_list: D001323:Autoantibodies; D002121:Calcium Channel Blockers; D009568:Nitrendipine