title: Modifications of histone cores and tails in V(D)J recombination.
abstract: The organization of chromatin and modifications to the tails of histone proteins are thought to be important in regulating the rearrangement of V, D and J gene segments, which encode immunoglobulins and T-cell receptors. A recent study shows that methylated lysine 79 in the core region of histone H3 also plays a role by providing a euchromatic 'mark' that may regulate access of the V(D)J recombinase.
authors.affiliation: Laboratory of Molecular Immunoregulation, SAIC-Basic Science Program, National Cancer Institute, Frederick, MD 21701, USA. muegge@ncifcrf.gov
authors.forename: Kathrin
authors.initials: K
authors.lastname: Muegge
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D015322:Gene Rearrangement, B-Lymphocyte; D015329:Gene Rearrangement, T-Lymphocyte; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D007128:Immunoglobulin Fragments / Q000235:genetics*; D007133:Immunoglobulin Joining Region / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D008745:Methylation; D051379:Mice; D011995:Recombination, Genetic
chemical_list: D002843:Chromatin; D006657:Histones; D007128:Immunoglobulin Fragments; D007133:Immunoglobulin Joining Region; D007135:Immunoglobulin Variable Region