title: Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors.
abstract: Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS- associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.
authors.affiliation: Department of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Barozzi
authors.forename: Mario
authors.initials: M
authors.lastname: Luppi
authors.forename: Fabio
authors.initials: F
authors.lastname: Facchetti
authors.forename: Cristina
authors.initials: C
authors.lastname: Mecucci
authors.forename: Milena
authors.initials: M
authors.lastname: Alù
authors.forename: Ronit
authors.initials: R
authors.lastname: Sarid
authors.forename: Valeria
authors.initials: V
authors.lastname: Rasini
authors.forename: Luisa
authors.initials: L
authors.lastname: Ravazzini
authors.forename: Elisa
authors.initials: E
authors.lastname: Rossi
authors.forename: Silvana
authors.initials: S
authors.lastname: Festa
authors.forename: Barbara
authors.initials: B
authors.lastname: Crescenzi
authors.forename: Dana G
authors.initials: DG
authors.lastname: Wolf
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Schulz
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Torelli
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D000956:Antigens, Viral; D015234:HLA-A Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D016030:Kidney Transplantation / Q000009:adverse effects*; D014411:Neoplastic Stem Cells / Q000502:physiology*; D009687:Nuclear Proteins; D012514:Sarcoma, Kaposi / Q000209:etiology*; D012730:Sex Chromosomes; D014019:Tissue Donors
chemical_list: D018952:Antigens, CD34; D000956:Antigens, Viral; D015234:HLA-A Antigens; C069526:HLA-A*30 antigen; D006684:HLA-DR Antigens; D009687:Nuclear Proteins; C109540:latency-associated nuclear antigen