Intravenous toxicity of fructose-1,6-bisphosphate in rats.
Fructose-1,6-bisphosphate (FBP) is a bisphosphorilated sugar with a protective action against events that lead to cellular damage. The toxicity of the drug was assessed when administered intravenously in Wistar rats in doses of between 250 and 4000 mg/kg. Ionic calcium, total calcium, inorganic serum phosphate and the electrocardiographic profile of these animals were assessed. The lethal dose (LD(50)) was established by means of PROBIT processing. There was no reduction in the levels of total calcium, with the administration of increased doses of FBP, although there was a significant reduction in the levels of ionic calcium in those groups that received 250 mg/kg and over. The serum phosphate showed a significant statistical increase in those groups that received 750 mg/kg and over. The LD(50) obtained in 24 h was 1068 mg/kg. Though it was not possible to elucidate the toxic mechanism of FBP, the electrocardiogram (ECG) showed that all the rats died of cardiac arrest.
Nunes
Fernanda Bordignon
FB
Laboratório de Pesquisa em Biofisica, Departamento de Ciências Fisiológicas, Faculdade de Biociências, Pontificia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Gaspareto
Patrick Barcelos
PB
Santos
Roberto Christ Vianna
RC
de Assis
Márcio
M
Graziottin
Cássio Meyer
CM
Biolchi
Vanderlei
V
Alves Filho
José Carlos Farias
JC
Lunardelli
Adroaldo
A
Avila
Luís D
LD
Pires
Melissa Guerra Simões
MG
Wächter
Paulo Harald
PH
De Oliveira
Jarbas Rodrigues
JR
D000818:Animals; D002118:Calcium / Q000097:blood; D004562:Electrocardiography / Q000187:drug effects; D005635:Fructosediphosphates / Q000008:administration & dosage / Q000633:toxicity*; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008297:Male; D010710:Phosphates / Q000097:blood; D051381:Rats; D017208:Rats, Wistar
D005635:Fructosediphosphates; D010710:Phosphates; C029063:fructose-1,6-diphosphate; D002118:Calcium