title: Magnetic resonance evaluation of luminal patency after polylactide stent implantation: an experimental study in a rabbit aorta model.
abstract: Intravascular metallic stents cause magnetic field distortions, disturbing luminal detection. Our aim was to evaluate the effect of polylactic acid (PLA) stents on magnetic resonance angiography (MRA). Biodegradable double spiral helical PLA stents ( n=12) or stainless steel (SS) ( n=6) stents were implanted into the infrarenal aortas of New Zealand White rabbits. All SS- and 6 PLA-stented animals as well as 6 non-operated control rabbits were imaged with gadolinium-enhanced MRA (1.5 T), and infrarenal aortic diameters (proximal, distal, and narrowest), together with the stent artifact, were measured. Six of the PLA-stented rabbits were followed up, and MRA was assessed at 2, 6, 9, and 12 months after the stent implantation. Image artifacts caused by the SS stents were visualized in all cases. The PLA stents caused no magnetic field distortion, allowing imaging of the underlying vessel including the vessel lumen. In the follow-up group of 6 rabbits with a PLA stent, 5 of 6 were patent at the end of the follow-up of 12 months. These stents allowed luminal detection at all time points, with no significant differences in aortic measurements emerging during the whole follow-up period. When immediately postoperatively scanned SS and PLA rabbits were compared with controls, no differences were observable in proximal diameters. Instead, the percentage of distal luminal loss was greater in the PLA-stented rabbits, as compared with SS stents ( p<0.01). The PLA stenting in small vessels allows evaluation of luminal patency with MRA both immediately after implantation and during follow-up.
authors.affiliation: Department of Surgery, P.O. Box 340, Helsinki University Hospital, 00029 Helsinki, Finland. eeva-maija.hietala@hus.fi
authors.forename: Eeva-Maija
authors.initials: EM
authors.lastname: Hietala
authors.forename: Paula
authors.initials: P
authors.lastname: Maasilta
authors.forename: Anders
authors.initials: A
authors.lastname: Ståhls
authors.forename: Ulla-Stina
authors.initials: US
authors.lastname: Salminen
authors.forename: Ari L J
authors.initials: AL
authors.lastname: Harjula
authors.forename: Tero
authors.initials: T
authors.lastname: Välimaa
authors.forename: Leena
authors.initials: L
authors.lastname: Kivisaari
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D001018:Aortic Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D019917:Blood Vessel Prosthesis Implantation; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005549:Foreign-Body Reaction / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D007083:Iliac Artery / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D018810:Magnetic Resonance Angiography; D008297:Male; D008955:Models, Cardiovascular; D011091:Polyesters / Q000494:pharmacology*; D011817:Rabbits; D011859:Radiography; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D015607:Stents; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors; D014654:Vascular Patency / Q000187:drug effects* / Q000502:physiology*
chemical_list: D020099:Coated Materials, Biocompatible; D011091:Polyesters; C033616:poly(lactide)