title: Membrane and synaptic effects of anti-S-100 are prevented by the same antibodies in low concentrations.
abstract: Effects of antiserum to S-100 protein (AS-100) in high (HC, corresponding to antiserum dilution 1:5 - 1:50) and low (LC, 1:10(12)) concentrations were studied in identified snail neurons and rat hippocampal slices. HC-AS-100 changed the frequency of action potential generation in spontaneously active neurons and blocked formation of long-term potentiation in mossy fiber synapses. LC-AS-100 alone did not affect any characteristic measured in our experiments, but 20 min pre-incubation of snail ganglia or hippocampal slices with LC-AS-100 abolished the effects of the same antibodies in HC. Simultaneous addition of both LC and HC did not prevent the development of HC-AS-100 effects. It seems possible that LC-AS-100 is capable of interaction with neuronal cells modifying their reaction to HC-AS-100.
authors.affiliation: Materia Medica Holding Research and Production Company, Moscow, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
authors.forename: A
authors.initials: A
authors.lastname: Beregovoy
authors.forename: N S
authors.initials: NS
authors.lastname: Sorokina
authors.forename: M V
authors.initials: MV
authors.lastname: Starostina
authors.forename: M B
authors.initials: MB
authors.lastname: Shtark
authors.forename: Kh L
authors.initials: KhL
authors.lastname: Gainutdinov
authors.forename: T Kh
authors.initials: TKh
authors.lastname: Gainutdinova
authors.forename: D I
authors.initials: DI
authors.lastname: Muhamedshina
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000502:physiology*; D004306:Dose-Response Relationship, Immunologic; D017774:Long-Term Potentiation / Q000502:physiology; D008564:Membrane Potentials / Q000276:immunology* / Q000502:physiology; D019599:Mossy Fibers, Hippocampal / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D051381:Rats; D009418:S100 Proteins / Q000276:immunology* / Q000378:metabolism; D012908:Snails; D013569:Synapses / Q000276:immunology* / Q000502:physiology
chemical_list: D001323:Autoantibodies; D009418:S100 Proteins