title: Endocrine abnormalities in patients with central serous chorioretinopathy.
abstract: OBJECTIVE
  To investigate and to identify endocrine and metabolic abnormalities in patients with central serous chorioretinopathy (CSCR).
  
  
  METHODS
  Observational case series.
  
  
  METHODS
  Twenty-four patients with CSCR.
  
  
  METHODS
  Serum and urinary catecholamines, glucocorticoids, mineralocorticoids, serum testosterone, and thyroid-stimulating hormone (TSH) function were evaluated prospectively.
  
  
  RESULTS
  Fifty percent (12 of 24) of patients with active acute CSCR showed elevated 24-hour urine cortisol or tetrahydroaldosterone levels. Serum aldosterone levels were low in 7 of 24 (29.1%) patients. Single morning plasma catecholamine levels were elevated in 7 of 24 patients, although 24-hour urine metanephrines (catecholamine breakdown products) were normal. Serum testosterone and TSH levels were normal in nearly all (23 of 24) patients.
  
  
  CONCLUSIONS
  Many patients with acute CSCR have elevated 24-hour urine corticosteroids, which may contribute to the pathogenesis of the disorder. Endogenous mineralocorticoid dysfunction is a newly described feature of CSCR.
authors.affiliation: Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Haimovici
authors.forename: Shimon
authors.initials: S
authors.lastname: Rumelt
authors.forename: James
authors.initials: J
authors.lastname: Melby
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000097:blood / Q000652:urine; D000328:Adult; D002395:Catecholamines / Q000097:blood; D015862:Choroid Diseases / Q000097:blood / Q000150:complications* / Q000652:urine; D004700:Endocrine System Diseases / Q000097:blood / Q000150:complications* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012164:Retinal Diseases / Q000097:blood / Q000150:complications* / Q000652:urine; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood
chemical_list: D000305:Adrenal Cortex Hormones; D002395:Catecholamines; D013739:Testosterone; D013972:Thyrotropin