title: [Management of head and neck Langerhan's cell histiocytosis in children].
abstract: OBJECTIVE
  Langerhan's cell histiocytosis is an uncommon disease characterized by abnormal proliferation of Langerhan's cells into different organs and tissues. Head and neck involvement is commonly described and presents a difficult management challenge. We report our experience at the Lille University Hospital and review the main features of this disease and current management strategies.
  
  
  METHODS
  We analyzed retrospectively 25 cases of Langerhan's cell histiocytosis treated in our center between 1978 and 2001. Attention was focused on head and neck involvement in order to assess the clinical, therapeutic, and prognostic significance of these localizations.
  
  
  RESULTS
  Head and neck involvement is frequently encountered in Langerhan's cell histiocytosis. Although morbidity and mortality are changed little by this localization, management decisions are greatly affected. A multidisciplinary approach is necessary.
  
  
  CONCLUSIONS
  Current therapeutic approaches are in favor of a wait and see policy or chemotherapy instead of aggressive local treatments including surgery or radiotherapy.
authors.affiliation: Service d'otologie et d'oto-neurochirurgie, Centre hospitalier régional universitaire, 59000 Lille. benjamin.lallemant@voilà.fr
authors.forename: B
authors.initials: B
authors.lastname: Lallemant
authors.forename: P
authors.initials: P
authors.lastname: Fayoux
authors.forename: B
authors.initials: B
authors.lastname: Nelken
authors.forename: X
authors.initials: X
authors.lastname: Leroy
authors.forename: F-M
authors.initials: FM
authors.lastname: Vaneecloo
mesh_terms: D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D008437:Maxilla / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D009915:Orbit / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D011859:Radiography; D012189:Retrospective Studies; D013701:Temporal Bone / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*
vernacular_title: Du diagnostic à la prise en charge des localisations ORL de l'histiocytose Langerhansienne chez l'enfant.