Effect of organochlorine pesticides on maturation of starfish and mouse oocytes.
Methoxychlor, lindane, and dieldrin are organochlorine pesticides that have been described as altering different reproductive functions in mammals and in invertebrates. However, few data have been published concerning the effects these pesticides have on oocyte maturation and fertilization. The aim of this study was to determine whether these compounds could affect maturation of mouse and starfish oocytes. We observed that germinal vesicle breakdown (GVBD) in starfish oocytes was significantly inhibited by the pesticides. Furthermore, formation of the first meiotic spindle and extrusion of the first polar body were also altered in mouse as well as in starfish. Our results suggest that the three pesticides act on common intracellular targets in invertebrates as well as in vertebrates.
Picard
André
A
Laboratoire Arago, BP 44, Banyuls sur Mer F-66651 Cedex, France.
Pahlavan
Golbahar
G
Palavan
Golbahar
G
Robert
Stéphanie
S
Pesando
Danielle
D
Ciapa
Brigitte
B
D000818:Animals; D004026:Dieldrin / Q000633:toxicity; D005260:Female; D005455:Fluorescent Antibody Technique; D001556:Hexachlorocyclohexane / Q000633:toxicity; D066298:In Vitro Techniques; D007306:Insecticides / Q000633:toxicity*; D008540:Meiosis / Q000187:drug effects; D008731:Methoxychlor / Q000633:toxicity; D051379:Mice; D009865:Oocytes / Q000187:drug effects / Q000254:growth & development*; D008941:Spindle Apparatus / Q000187:drug effects; D013215:Starfish / Q000254:growth & development*; D016707:Tissue Fixation
D007306:Insecticides; D001556:Hexachlorocyclohexane; D004026:Dieldrin; D008731:Methoxychlor