title: Hormesis and stage specific toxicity induced by cadmium in an insect model, the queen blowfly, Phormia regina Meig.
abstract: Hormesis is an adaptive response, commonly characterized by a biphasic dose-response that can be either directly induced, or the result of compensatory biological processes following an initial disruption in homeostasis [Calabrese and Baldwin, Hum. Exp.Toxicol., 21 (2002), 91]. Low and environmentally relevant levels of dietary cadmium significantly enhanced the pupation rate of blowfly larvae, while higher doses inhibited pupation success. However, dietary cadmium at all exposure levels adversely affected the emergence of the adult fly from the pupal case. Such findings represent the first report of a heavy metal displaying a hormetic-like biphasic response for pupation success, while at the same time displaying stage-specific toxicity at a later developmental period. These conclusions are based on substantial experimentation of over 1750 blowflies, in seven replicate experiments, involving 10 concentrations per experiment. These findings indicate the need to assess the impact of environmental stressors over a broad range of potential exposures as well as throughout the entire life cycle.
authors.affiliation: Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Box 41163, Lubbock, TX 79409-1163, USA. marc.nascarella@tiehh.ttu.edu
authors.forename: Marc A
authors.initials: MA
authors.lastname: Nascarella
authors.forename: John G
authors.initials: JG
authors.lastname: Stoffolano
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Stanek
authors.forename: Paul T
authors.initials: PT
authors.lastname: Kostecki
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Calabrese
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D004175:Diptera / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000633:toxicity*; D007814:Larva / Q000187:drug effects; D008675:Metamorphosis, Biological / Q000187:drug effects*; D008954:Models, Biological; D011679:Pupa
chemical_list: D004785:Environmental Pollutants; D002104:Cadmium