Role of the brain heme oxygenase-carbon monoxide pathway in stress fever in rats.
This study was aimed at testing the hypothesis that the brain heme oxygenase (HO)-carbon monoxide (CO) pathway plays a role in stress fever. To this end, the effect of the HO inhibitor, zinc deuteroporphyrin 2,4-bis glycol (ZnDPBG), on restraint-induced fever was tested. Intracerebroventricular ZnDPBG (200 nmol) did not affect the body core temperature of unrestrained rats, but markedly attenuated restraint-induced fever. However, at the same dose, intraperitoneal ZnDPBG did not affect the febrile response to restraint. Taken together, these results indicate that the brain HO-CO pathway plays a major role in the genesis of stress fever in rats.
Steiner
Alexandre A
AA
Department of Physiology, Medical School of Ribeirao Preto, SP, Brazil. a2steiner@chw.edu
Reste
Gustavo
G
Branco
Luiz G S
LG
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002248:Carbon Monoxide / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005334:Fever / Q000201:enzymology*; D006419:Heme Oxygenase (Decyclizing) / Q000037:antagonists & inhibitors / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013312:Stress, Physiological / Q000201:enzymology*
D004791:Enzyme Inhibitors; D002248:Carbon Monoxide; D006419:Heme Oxygenase (Decyclizing)