title: Altered fetal circulation in type-1 diabetic pregnancies.
abstract: OBJECTIVE
  Type-I diabetic pregnancies are associated with congenital cardiac malformations, fetal cardiomyopathy, venous thrombosis and altered placental vascularization, even with tight maternal glucose control. The aim of this study was to investigate if, with good glucose control achieved with continuous subcutaneous insulin infusion, normal blood flow within the fetal heart can be achieved.
  
  
  METHODS
  Seventeen fetuses of women with well-controlled type-I diabetes were studied longitudinally to evaluate effects on the fetal circulation. Doppler frequency shift tracings, valve diameters and intercept angles were measured at right and left atrioventricular valve orifices at 4-week intervals starting at 15 weeks' gestation. Atrioventricular valve flow was calculated and compared to normal fetal data obtained in previous studies.
  
  
  RESULTS
  Maximum and mean temporal velocities across the atrioventricular valves increased in both groups during gestation but significantly more in fetuses of type-I diabetic pregnancies. Combined ventricular output, both absolute and per kg estimated fetal weight, were also greater in these fetuses. In the normal group the ratio of the right/left ventricular output decreased significantly during gestation (from 1.34 +/- 0.28 to 1.08 +/- 0.28 standard deviations), but in type-I diabetic pregnancies this decrease did not occur (1.2 +/- 0.26 to 1.25 +/- 0.29 standard deviations)[corrected].
  
  
  CONCLUSIONS
  These data indicate that there are significant differences in the fetal circulation between normal pregnancy and well-controlled type-I diabetic pregnancy, suggesting the existence of a compensatory mechanism which increases fetal cardiac output and causes cardiac hypertrophy.
authors.affiliation: Department of Obstetrics and Gynecology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands.
authors.forename: L A
authors.initials: LA
authors.lastname: Lisowski
authors.forename: P M
authors.initials: PM
authors.lastname: Verheijen
authors.forename: M M C
authors.initials: MM
authors.lastname: De Smedt
authors.forename: G H A
authors.initials: GH
authors.lastname: Visser
authors.forename: E J
authors.initials: EJ
authors.lastname: Meijboom
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D003326:Coronary Circulation; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005260:Female; D005333:Fetus / Q000098:blood supply*; D005865:Gestational Age; D006801:Humans; D008137:Longitudinal Studies; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology*