Selection of intracellular calcium patterns in a model with clustered Ca2+ release channels.
A two-dimensional model is proposed for intracellular Ca2+ waves, which incorporates both the discrete nature of Ca2+ release sites in the endoplasmic reticulum membrane and the stochastic dynamics of the clustered inositol 1,4,5-triphosphate (IP3) receptors. Depending on the Ca2+ diffusion coefficient and concentration of IP3, various spontaneous Ca2+ patterns, such as calcium puffs, local waves, abortive waves, global oscillation, and tide waves, can be observed. We further investigate the speed of the global waves as a function of the IP3 concentration and the Ca2+ diffusion coefficient and under what conditions the spatially averaged Ca2+ response can be described by a simple set of ordinary differential equations.
Shuai
J W
JW
Department of Physics and Astronomy and Quantitative Biology Institute, Ohio University, Athens, Ohio 45701, USA. shuai@helios.phy.ohiou.edu
Jung
P
P
D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D004058:Diffusion; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum; D053496:Inositol 1,4,5-Trisphosphate Receptors; D015233:Models, Statistical; D009865:Oocytes / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D014981:Xenopus
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D002118:Calcium