title: Hemocompatibility of titanium oxide films.
abstract: Hemocompatibility is a key property of biomaterials that come in contact with blood. Surface modification has shown great potential for improving the hemocompatibility of biomedical materials and devices. In this paper, we describe our work of improving hemocompatibility with Ti-O thin films prepared by plasma immersion ion implantation and deposition and by sputtering. The structure and surface chemical and physical properties of the films were characterized by X-ray diffraction, Auger electron spectroscopy, atomic force microscopy (AFM), contact angle measurement, and Hall effect measurement. The behavior of fibrinogen adsorption was investigated by 125I radioactive isotope labeling and AFM. Systematic evaluation of hemocompatibility, including in vitro clotting time, thrombin time, prethrombin time, platelet adhesion, and in vivo implantation into dog's ventral aorta or right auricle from 17 to 90 days, proved that Ti-O films have excellent hemocompatibility. It is suggested that the significantly lower interface tension between Ti-O films and blood and plasma proteins and the semiconducting nature of Ti-O films give them their improved hemocompatibility.
authors.affiliation: Institute of Biomaterials and Surface Engineering, School of Materials Sciences and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, China. huangnan@sc.homeway.com.cn
authors.forename: N
authors.initials: N
authors.lastname: Huang
authors.forename: P
authors.initials: P
authors.lastname: Yang
authors.forename: Y X
authors.initials: YX
authors.lastname: Leng
authors.forename: J Y
authors.initials: JY
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Sun
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: G J
authors.initials: GJ
authors.lastname: Wang
authors.forename: P D
authors.initials: PD
authors.lastname: Ding
authors.forename: T F
authors.initials: TF
authors.lastname: Xi
authors.forename: Y
authors.initials: Y
authors.lastname: Leng
mesh_terms: D000327:Adsorption; D000818:Animals; D001792:Blood Platelets / Q000737:chemistry / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D004285:Dogs; D005340:Fibrinogen / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D006350:Heart Valve Prosthesis; D006648:Histocompatibility / Q000187:drug effects*; D006801:Humans; D008422:Materials Testing; D008968:Molecular Conformation; D015539:Platelet Activation / Q000187:drug effects* / Q000502:physiology; D010973:Platelet Adhesiveness / Q000187:drug effects / Q000502:physiology; D011474:Prosthesis Design; D013499:Surface Properties; D013927:Thrombosis / Q000473:pathology / Q000517:prevention & control; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D020099:Coated Materials, Biocompatible; C009495:titanium dioxide; D005340:Fibrinogen; D014025:Titanium