title: Realizing the potential of the genome revolution: the genomes to life program.
abstract: The systems biology revolution is proceeding along multiple pathways as different science agencies and the private sector have adopted strategies suited to their particular needs and cultures. To meet this challenge, the U.S. Department of Energy has developed the Genomes to Life (GTL) program. A central focus of GTL is environmental microbial biology as a way to approach global environmental problems, and its key goal is to achieve, over the next 10 to 20 years, a basic understanding of thousands of microbes and microbial systems in their native environments. This focus demands that we address huge gaps in knowledge, technology, computing, data storage and manipulation, and systems-level integration.
authors.affiliation: U.S. Department of Energy, Office of Science, Office of Biological and Environmental Research, SC-70, Germantown Building, 1000 Independence Avenue, S.W., Washington, DC 20585-1290, USA.
authors.forename: Marvin E
authors.initials: ME
authors.lastname: Frazier
authors.forename: Gary M
authors.initials: GM
authors.lastname: Johnson
authors.forename: David G
authors.initials: DG
authors.lastname: Thomassen
authors.forename: Carl E
authors.initials: CE
authors.lastname: Oliver
authors.forename: Aristides
authors.initials: A
authors.lastname: Patrinos
mesh_terms: D001709:Biotechnology; D002980:Climate; D019295:Computational Biology; D004736:Energy-Generating Resources; D004777:Environment; D004783:Environmental Microbiology; D004787:Environmental Pollution; D035082:Federal Government; D005827:Genetics, Microbial; D016680:Genome, Bacterial; D016681:Genome, Fungal; D023281:Genomics; D006077:Government Agencies; D008954:Models, Biological; D020543:Proteome / Q000032:analysis; D040901:Proteomics; D014481:United States
chemical_list: D020543:Proteome