title: Control of triglyceride storage by a WD40/TPR-domain protein.
abstract: Obesity is a metabolic disorder related to improper control of energy uptake and expenditure, which results in excessive accumulation of body fat. Initial insights into the genetic pathways that regulate energy metabolism have been provided by a discrete number of obesity-related genes that have been identified in mammals. Here, we report the identification of the adipose (adp) gene, the mutation of which causes obesity in Drosophila. Loss of adp activity promotes increased fat storage, which extends the lifespan of mutant flies under starvation conditions. By contrast, adp gain-of-function causes a specific reduction of the fat body in Drosophila. adp encodes an evolutionarily conserved WD40/tetratricopeptide-repeat-domain protein that is likely to represent an intermediate in a novel signalling pathway.
authors.affiliation: DeveloGen AG, Rudolf-Wissell-Strasse 28, 37079 Göttingen, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Häder
authors.forename: Sandra
authors.initials: S
authors.lastname: Müller
authors.forename: Miguel
authors.initials: M
authors.lastname: Aguilera
authors.forename: Karsten G
authors.initials: KG
authors.lastname: Eulenberg
authors.forename: Arnd
authors.initials: A
authors.lastname: Steuernagel
authors.forename: Thomas
authors.initials: T
authors.lastname: Ciossek
authors.forename: Ronald P
authors.initials: RP
authors.lastname: Kühnlein
authors.forename: Lydia
authors.initials: L
authors.lastname: Lemaire
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Fritsch
authors.forename: Cord
authors.initials: C
authors.lastname: Dohrmann
authors.forename: Ingrid R
authors.initials: IR
authors.lastname: Vetter
authors.forename: Herbert
authors.initials: H
authors.lastname: Jäckle
authors.forename: Winifred W
authors.initials: WW
authors.lastname: Doane
authors.forename: Günter
authors.initials: G
authors.lastname: Brönner
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry; D029721:Drosophila Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics*; D004734:Energy Metabolism / Q000235:genetics; D019143:Evolution, Molecular; D005216:Fat Body / Q000378:metabolism*; D007814:Larva / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D009154:Mutation; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D016415:Sequence Alignment; D014280:Triglycerides / Q000235:genetics / Q000378:metabolism*
chemical_list: D018076:DNA, Complementary; D029721:Drosophila Proteins; D011506:Proteins; D014280:Triglycerides; C490481:adp protein, Drosophila