title: Becker's nevus with ipsilateral breast hypoplasia: improvement with spironolactone.
abstract: Ipsilateral breast hypoplasia is a rare abnormality in Becker's nevus. The pathogenesis of the breast hypoplasia is not understood, but an increased level of androgenic receptor in the affected area may play a role. We report a case of Becker's nevus with ipsilateral breast hypoplasia. Spironolactone, an anti-androgenic agent, was tried for treatment of the hypoplasia, and, one month later, breast enlargement was seen in only the hypoplastic breast with Becker's nevus. This finding supports the theory that breast hypoplasia in Becker's nevus is related to an increase in androgenic receptor.
authors.affiliation: Department of Dermatology, College of Medicine, Dankook University Hospital, Cheonan, Korea.
authors.forename: Jae
authors.initials: J
authors.lastname: Hoon Jung
authors.forename: You
authors.initials: Y
authors.lastname: Chan Kim
authors.forename: Hyang
authors.initials: H
authors.lastname: Joon Park
authors.forename: Yong
authors.initials: Y
authors.lastname: Woo Cinn
mesh_terms: D000293:Adolescent; D001940:Breast / Q000187:drug effects / Q000473:pathology*; D005260:Female; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use*; D009508:Nevus, Pigmented / Q000150:complications* / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology; D013148:Spironolactone / Q000627:therapeutic use*
chemical_list: D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone