title: [Changes in prostate specific antigen levels during intravesical instillations with Calmette-Guerin bacillus: relationship with transurethral resection of the prostate].
abstract: OBJECTIVE
  To evaluate variations on the serum PSA levels during and after administration of intravesical BCG and its relationship with previous transurethral resection of the prostate (TURP).
  
  
  METHODS
  PSA serum concentration variations were studied after each instillation, at 1 month and at 3 months in 24 patients with superficial bladder cancer and/or CIS under weekly BCG instillations treatment. Three patients had undergone TURP.
  
  
  RESULTS
  A raise in PSA was observed in 87.5% of the cases during BCG instillations, although the increase was only significative in patients who had undergone TURP. PSA values descended at one and three months.
  
  
  CONCLUSIONS
  Endovesical BCG administration produces an increase on serum PSA levels. This variation is higher in patients with history of TURP.
authors.affiliation: Servicio de Urología, Fundació Puigvert, Barcelona, España.
authors.forename: Héctor
authors.initials: H
authors.lastname: López Llauradó
authors.forename: Juan
authors.initials: J
authors.lastname: Palou Redorta
authors.forename: Rosario
authors.initials: R
authors.lastname: Montañés Bermúdez
authors.forename: Artur Oliver
authors.initials: AO
authors.lastname: Samper
authors.forename: Josep Salvador
authors.initials: JS
authors.lastname: Bayarri
authors.forename: Humberto
authors.initials: H
authors.lastname: Villavicencio Mavrich
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000283:Administration, Intravesical; D001500:BCG Vaccine / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood* / Q000628:therapy*; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D017430:Prostate-Specific Antigen
vernacular_title: Variación de los niveles de antígeno prostático específico durante las instilaciones endovesicales de bacilo de Calmette-Guerin: relación con la resección transuretral de próstata.