title: [Leptomeningeal carcinomatosis as the first clinical manifestation of lung adenocarcinoma: case report].
abstract: Leptomeningeal carcinomatosis is a neurological complication of several systemic tumors and is characterized by multifocal invasion of the meninges by neoplastic cells. It is estimated that 5% of all patients with cancer will present leptomeningeal carcinomatosis at some time during the course of the illness. Clinical manifestations are heterogeneous and present with signs and symptoms related to involvement of multiple areas of the nervous system, particularly cranial nerves and spinal roots. The diagnosis is based on suggestive clinical findings, cerebrospinal fluid (CSF) testing and imaging studies. The most informative findings come from CSF where the presence of neoplastic cells is definitive for the diagnosis. The purpose of this report is to describe, along with a review of the literature, a clinical case of a 42 years old man in whom the first clinical signs of a lung cancer manifested with symptoms suggestive of meningeal involvement.
authors.affiliation: Médicina Residente de Clínica Médica do Hospital Ipiranga, São Paulo, SP, Brasil.
authors.forename: Andréa
authors.initials: A
authors.lastname: Gimenez
authors.forename: João Carlos Papaterra
authors.initials: JC
authors.lastname: Limongi
authors.forename: Anna Carolina Tavares
authors.initials: AC
authors.lastname: Valente
authors.forename: Cristiane
authors.initials: C
authors.lastname: Gimenez
authors.forename: Jair Urbano
authors.initials: JU
authors.lastname: da Silva
mesh_terms: D000230:Adenocarcinoma / Q000134:cerebrospinal fluid / Q000556:secondary*; D000328:Adult; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid / Q000556:secondary*
vernacular_title: Carcinomatose leptomeníngea como primeira manifestação de adenocarcinoma pulmonar: relato de caso.