title: FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase (HDAC). I. Taxonomy, fermentation, isolation and biological activities.
abstract: A cyclic tetrapeptide FR235222, a novel immunosuppressant, has been isolated from the fermentation broth of a fungus, Acremonium sp. No. 27082. FR235222 showed potent and selective inhibitory effects on both T cell proliferation and lymphokine production. Further study has revealed this compound exhibits potent inhibitory effects on the activity of mammalian histone deacetylases (HDACs).
authors.affiliation: Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan. hiroaki_mori@po.fujisawa.co.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Mori
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Urano
authors.forename: Fumie
authors.initials: F
authors.lastname: Abe
authors.forename: Satoko
authors.initials: S
authors.lastname: Furukawa
authors.forename: Shigetada
authors.initials: S
authors.lastname: Furukawa
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Tsurumi
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Michizane
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Takase
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hino
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujii
mesh_terms: D000164:Acremonium / Q000737:chemistry / Q000145:classification / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D004791:Enzyme Inhibitors / Q000276:immunology / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D005285:Fermentation; D022781:Hepatocytes / Q000187:drug effects / Q000276:immunology; D056572:Histone Deacetylase Inhibitors; D007166:Immunosuppressive Agents / Q000276:immunology / Q000302:isolation & purification* / Q000494:pharmacology; D007376:Interleukin-2 / Q000276:immunology / Q000378:metabolism; D015847:Interleukin-4 / Q000276:immunology / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D010456:Peptides, Cyclic / Q000276:immunology / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D012988:Soil Microbiology; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology
chemical_list: D004791:Enzyme Inhibitors; C474179:FR 235222; D056572:Histone Deacetylase Inhibitors; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D010456:Peptides, Cyclic; D015847:Interleukin-4