Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen.
Given the poor prognosis of patients with advanced cutaneous T-cell lymphoma and the high transplant-related mortality associated with conventional allogeneic bone marrow transplantation, we performed nonmyeloablative transplantation of allogeneic stem cells (ASCT) from HLA-identical siblings in three patients with this disease. All patients achieved full donor engraftment, clearance of clonal T cells leading to durable complete remissions but experienced high incidence of infections, which proved fatal in one case. These results suggest that nonmyeloablative ASCT is a novel and potentially curative therapy for patients with advanced T-cell lymphomas who have a histocompatible sibling.
Soligo
D
D
Department of Hematology, IRCCS Ospedale Maggiore Milano, Italy.
Ibatici
A
A
Berti
E
E
Morandi
P
P
Longhi
E
E
Venegoni
L
L
Corbellino
M
M
Annaloro
C
C
Robbiolo
L
L
Della Volpe
A
A
Alessi
E
E
Lambertenghi Deliliers
G
G
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016410:Lymphoma, T-Cell, Cutaneous / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D016133:Polymerase Chain Reaction; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics; D033581:Stem Cell Transplantation / Q000009:adverse effects; D018183:Transplantation Chimera / Q000276:immunology; D014184:Transplantation, Homologous
D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D016692:Receptors, Antigen, T-Cell, gamma-delta