title: Whole-blood manganese levels and brain manganese accumulation in children receiving long-term home parenteral nutrition.
abstract: Recent reports attribute neurological and cerebral disorders to the accumulation of manganese (Mn) in the brain in patients receiving home parenteral nutrition (HPN). It is desirable to control the amount of Mn delivered to these patients, but a suitable method for monitoring an individual's Mn status and assessing Mn accumulation remains debatable. The aim of this study was to evaluate whether whole-blood manganese levels (WB-Mn) correlate with the accumulation of Mn in the brains of children who receive long-term HPN, using magnetic resonance imaging (MRI) of the brain. Six patients who had received HPN (duration of HPN, 18-137 months) were included in this study. The daily parenteral doses of Mn were calculated while on HPN. WB-Mn was measured and T1-weighted MRI of the brain was obtained for each patient with a 1.5-T MR imager. Twelve months after the withdrawal of Mn from HPN, measurements of WB-Mn and brain MRI were repeated in all patients except for one who was lost after initial examination. The same examinations were performed on an additional patient who had been successfully weaned off a 179 month course of HPN 20 months prior to the initial examination. The parenteral dose of Mn while receiving HPN ranged from 15.7 to 91.5 micro g/kg/day. Initially, MRI showed hyperintensity in the globus pallidus in all patients and in the anterior pituitary in one patient. WB-Mn was elevated in four patients, but was in the normal range in the remaining three. Following subsequent measurements 12 months later, WB-Mn was normal in all patients and MRI hyperintensity remained in the globus pallidus in one patient. One patient was lost after the initial examinations. WB-Mn does not necessarily correlate with the accumulation of Mn in the brain. Periodic MRI should be performed in patients receiving long-term NPN to monitor for excessive Mn accumulation in the brain.
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine Niigata University, 1-757 Asahimachi-dori, 951-8520, Niigata City, Japan. iinuma@med.niigata-u.ac.jp
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Iinuma
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kubota
authors.forename: Masanori
authors.initials: M
authors.lastname: Uchiyama
authors.forename: Minoru
authors.initials: M
authors.lastname: Yagi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kanada
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Murata
authors.forename: Kouichirou
authors.initials: K
authors.lastname: Okamoto
authors.forename: Masashi
authors.initials: M
authors.lastname: Suzuki
authors.forename: Kohjyu
authors.initials: K
authors.lastname: Nitta
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005917:Globus Pallidus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008345:Manganese / Q000097:blood / Q000378:metabolism*; D008991:Monitoring, Physiologic; D016331:Parenteral Nutrition, Home; D013997:Time Factors
chemical_list: D008345:Manganese