title: [Polymer coatings with immobilized thrombin and peptides: preparation and use for wound healing].
abstract: Polymer dressings with encapsulated thrombin or synthetic peptides which can mimic thrombin action are employed for wound healing. Paper describes the method for preparation of these hydrogel composites of PVCL-CaAlg [poly(N-vinyl caprolactam-calcium alginate). The effect of encapsulated thrombin/peptides on tissue repair process have beet investigatat in vivo experiments using a mouse model of wound healing. The developed dressings accelerated wound healing: thascan be used as a basis for creation of novel formulations with controlled drug release for wound therapy.
authors.affiliation: Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Str. 16/10, Moscow, 117997 Russia. lemark@ibch.ru
authors.forename: E A
authors.initials: EA
authors.lastname: Markvicheva
authors.forename: S V
authors.initials: SV
authors.lastname: Kuptsova
authors.forename: L D
authors.initials: LD
authors.lastname: Rumsh
authors.forename: T N
authors.initials: TN
authors.lastname: Dugina
authors.forename: M A
authors.initials: MA
authors.lastname: Lange
authors.forename: I V
authors.initials: IV
authors.lastname: Chistov
authors.forename: S M
authors.initials: SM
authors.lastname: Strukova
authors.forename: V P
authors.initials: VP
authors.lastname: Zubov
mesh_terms: D000464:Alginates / Q000737:chemistry; D000818:Animals; D002209:Caprolactam / Q000031:analogs & derivatives* / Q000737:chemistry; D004337:Drug Carriers; D004800:Enzymes, Immobilized; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D020100:Hydrogels; D051379:Mice; D008808:Mice, Inbred CBA; D010446:Peptide Fragments / Q000737:chemistry* / Q000627:therapeutic use; D011108:Polymers / Q000737:chemistry; D044463:Receptor, PAR-1; D044464:Receptor, PAR-2; D018179:Receptors, Thrombin / Q000819:agonists; D013917:Thrombin / Q000737:chemistry* / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000464:Alginates; D004337:Drug Carriers; D004800:Enzymes, Immobilized; D006603:Hexuronic Acids; D020100:Hydrogels; D010446:Peptide Fragments; D011108:Polymers; D044463:Receptor, PAR-1; D044464:Receptor, PAR-2; D018179:Receptors, Thrombin; C082835:thrombin receptor peptide (42-47); C086861:poly-N-vinylcaprolactam; D002209:Caprolactam; D020723:Glucuronic Acid; D013917:Thrombin
vernacular_title: Polimernye pokrytiia s immobilizovannymi v nikh trombinom ili peptidami: poluchenie i primenenie dlia ranozazhivleniia.