title: Epidemiologic correlates of antibody response to human papillomavirus among women at low risk of cervical cancer.
abstract: A population at low risk for developing cervical cancer in Southern Brazil was studied to identify the main determinants of serological response to human papillomavirus (HPV). Enzyme-linked immunosorbent assay tests were performed in 976 women to detect serum IgG antibodies against HPV 16 L1 virus-like particles (VLPs) and HPVs 16, 18, 6 and 11 L1 VLPs as a mixture of antigens. Women with four or more sexual partners were more likely to be seropositive than women with one partner (HPV 16 serology odds ratio [OR]=3.06, 95% confidence interval [CI]: 2.0-4.8; HPV 6/11/16/18 serology OR=4.64, 95% CI: 3.0-7.2). HPV DNA and both serological responses were associated. Those positives to HPV 16 serology were twice as likely to have a cytological diagnosis of squamous intraepithelial lesions (SILs) than seronegatives (OR=2.07; 95% CI: 1.0-4.5, and OR=1.73; 95% CI: 0.8-3.8). Seropositivity to HPV 16 and HPV 6/11/16/18 antigens seem to be better markers of past sexual activity than current HPV infection, and humoral response to HPV 16 or HPV 6/11/16/18 may not be a strong indicator of cervical lesions in populations at low risk for cervical lesions.
authors.affiliation: Posgraduação em Clínica Médica/UFRGS, Porto Alegre, Brazil. mcb@famed.ufrgs.br
authors.forename: B
authors.initials: B
authors.lastname: Nonnenmacher
authors.forename: J
authors.initials: J
authors.lastname: Pintos
authors.forename: M C
authors.initials: MC
authors.lastname: Bozzetti
authors.forename: I
authors.initials: I
authors.lastname: Mielzinska-Lohnas
authors.forename: A T
authors.initials: AT
authors.lastname: Lorincz
authors.forename: N
authors.initials: N
authors.lastname: Ikuta
authors.forename: G
authors.initials: G
authors.lastname: Schwartsmann
authors.forename: L L
authors.initials: LL
authors.lastname: Villa
authors.forename: J T
authors.initials: JT
authors.lastname: Schiller
authors.forename: E
authors.initials: E
authors.lastname: Franco
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000276:immunology* / Q000302:isolation & purification; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000821:virology*
chemical_list: D000914:Antibodies, Viral