title: Synthesis and inverse electron demand Diels-Alder reactions of 3,6-bis(3,4-dimethoxybenzoyl)-1,2,4,5-tetrazine.
abstract: The synthesis of 3,6-bis(3,4-dimethoxybenzoyl)-1,2,4,5-tetrazine (2) and the scope of its reactivity in inverse electron demand Diels-Alder reactions are disclosed representing the first systematic study of the [4 + 2] cycloaddition reactions of 3,6-diacyl-1,2,4,5-tetrazines.
authors.affiliation: Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Danielle R
authors.initials: DR
authors.lastname: Soenen
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Zimpleman
authors.forename: Dale L
authors.initials: DL
authors.lastname: Boger
mesh_terms: D020650:Combinatorial Chemistry Techniques; D006573:Heterocyclic Compounds, 1-Ring; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis*; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: C479322:3,6-bis(3,4-dimethoxybenzoyl)-1,2,4,5-tetrazine; D006573:Heterocyclic Compounds, 1-Ring; D006575:Heterocyclic Compounds, 3-Ring; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates; D007202:Indicators and Reagents