title: Association study between interleukin-1beta gene (IL-1beta) and schizophrenia.
abstract: An increasing amount of evidence suggests that the pathophysiology of schizophrenia is associated with the abnormal immune system, and cytokines may be important in schizophrenia. Among these cytokines, interleukin-1beta may play a role in the pathogenesis of the disease. In the present study, we investigated the genetic association between a TaqI polymorphism in interleukin-1beta gene (IL-1beta) and schizophrenia by restriction fragment length polymorphism (RFLP) analysis among 132 Chinese families of Han descent. The transmission disequilibrium test (TDT) did not demonstrate an allelic association with schizophrenia. Our results suggested that the TaqI polymorphism in IL-1beta gene might not confer increased susceptibility for schizophrenia.
authors.affiliation: Institute of Mental Health, Peking University, 100083, Beijing, China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Yang
authors.forename: Tianmei
authors.initials: T
authors.lastname: Si
authors.forename: Yansu
authors.initials: Y
authors.lastname: Ling
authors.forename: Yan
authors.initials: Y
authors.lastname: Ruan
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Han
authors.forename: Xiling
authors.initials: X
authors.lastname: Wang
authors.forename: Mo
authors.initials: M
authors.lastname: Zhou
authors.forename: Darong
authors.initials: D
authors.lastname: Zhang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhang
authors.forename: Qingmei
authors.initials: Q
authors.lastname: Kong
authors.forename: Cui
authors.initials: C
authors.lastname: Liu
authors.forename: Xueni
authors.initials: X
authors.lastname: Li
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Yu
authors.forename: Shuzeng
authors.initials: S
authors.lastname: Liu
authors.forename: Liang
authors.initials: L
authors.lastname: Shu
authors.forename: Dalong
authors.initials: D
authors.lastname: Ma
authors.forename: Jun
authors.initials: J
authors.lastname: Wei
authors.forename: Dai
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D002681:China; D005260:Female; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics* / Q000378:metabolism; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology
chemical_list: D007375:Interleukin-1