title: Catalytic alkynylation of ketones and aldehydes using quaternary ammonium hydroxide base.
abstract: Catalytic alkynylation of diverse ketones and aldehydes using nonmetallic benzyltrimethylammonium hydroxide or a basic resin of the hydroxide type in DMSO is described. Aliphatic or alicyclic carbonyl partners gave satisfactory results, whereas aromatic ones afforded products with low yields. When aromatic aldehydes were reacted with phenylacetylene, enones such as chalcone derivatives were obtained in place of ynols. These organobase-catalyzed systems provide a practical nonmetallic protocol for C[bond]C formation.
authors.affiliation: Department of Chemistry, School of Education, Okayama University, Tsushima, Okayama, 700-8530, Japan. seisaito@biotech.okayama-u.ac.jp
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Mizuta
authors.forename: Kumiko
authors.initials: K
authors.lastname: Hagiwara
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Aikawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kudo
authors.forename: Seiki
authors.initials: S
authors.lastname: Saito