[Application of molecular epidemiology in the study of occupational chemical carcinogenesis].
This paper described the concept of moleculalr epidemiology, it's differences from traditional epidemiology and what the author learned from conducting molecular epidemiology recently. 1. Molecular epidemiology is the borderline subject in combination of molecular biology with epidemiology. 2. The level of chemical carcinogen formed in vivo and the amount of combination of chemical carcinogen either in the level from vivo or in biologic effective dose of combination of chemical carcinogen with macromolecular are all related to cancer development. 3. The syndrome of chromosome aberration is an early biologic effect in cancer process and oncogen activation or suppressing gene inactivation might be necessary for malignant transformation from initiated cell. 4. Individual susceptibility could be affected by host and acquired factors. 5. Biologic bank could provide continuous observation and comparision between before and after cancer formation.
Li
G
G
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Yin
S
S
Dai
Y
Y
D002681:China / Q000453:epidemiology; D006801:Humans; D017720:Molecular Epidemiology; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology* / Q000235:genetics; D016273:Occupational Exposure; D009857:Oncogenes