Modifications of histone cores and tails in V(D)J recombination.
The organization of chromatin and modifications to the tails of histone proteins are thought to be important in regulating the rearrangement of V, D and J gene segments, which encode immunoglobulins and T-cell receptors. A recent study shows that methylated lysine 79 in the core region of histone H3 also plays a role by providing a euchromatic 'mark' that may regulate access of the V(D)J recombinase.
Muegge
Kathrin
K
Laboratory of Molecular Immunoregulation, SAIC-Basic Science Program, National Cancer Institute, Frederick, MD 21701, USA. muegge@ncifcrf.gov
D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D015322:Gene Rearrangement, B-Lymphocyte; D015329:Gene Rearrangement, T-Lymphocyte; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D007128:Immunoglobulin Fragments / Q000235:genetics*; D007133:Immunoglobulin Joining Region / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D008745:Methylation; D051379:Mice; D011995:Recombination, Genetic
D002843:Chromatin; D006657:Histones; D007128:Immunoglobulin Fragments; D007133:Immunoglobulin Joining Region; D007135:Immunoglobulin Variable Region