Catecholamine release in human heart by bupropion.
Although there are some data on the cardiovascular profile of bupropion, a non-nicotine-based pharmacotherapy for smoking cessation, detailed studies of its specifically cardiac effects are lacking. In particular, the direct action of this agent on human myocardial contractility is not known. Therefore, we investigated the effects of bupropion on human cardiac tissue in vitro. Our results suggest that bupropion exerts indirect sympathomimetic activity producing positive inotropic effects in human myocardium most probably by catecholamine release.
Cremers
Bodo
B
Medizinische Klinik und Poliklinik, Innere Medizin III, Universitätskliniken des Saarlandes, 66421 Homburg, Germany. cremers@med-in.uni-sb.de
Schmidt
Kathrin I
KI
Maack
Christoph
C
Schäfers
Hans Joachim
HJ
Böhm
Michael
M
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D016642:Bupropion / Q000494:pharmacology*; D002395:Catecholamines / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006325:Heart Atria / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D011412:Propanolamines / Q000494:pharmacology; D013268:Stimulation, Chemical
D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D011412:Propanolamines; D016642:Bupropion; C024307:bucindolol