Different chromogranin immunoreactivity between prion and a-beta amyloid plaque.
Brain lesions in Creutzfeldt-Jakob disease (CJD) include spongiform change, neuronal loss, amyloid plaques, astrogliosis and microglial activation. Microglia are thought to play a key role in prion-induced neurodegeneration. However, the intermediate molecules supporting relationships between neurons and microglia are still unknown. Chromogranins (Cg) are soluble glycophosphoproteins that can activate microglial cells leading to a neurotoxic phenotype. The immunoreactive patterns of CgA and CgB were investigated in CJD and compared to those observed in Alzheimer's disease. We found that CgB, but not CgA, immunoreactivity was selectively associated with prion protein deposits, whereas CgA was only seen in Abeta plaques. This suggests a specific influence of the constitutive amyloid protein on chromogranin secretion and a role of CgB in the CJD neurodegenerative process.
Rangon
Claire-Marie
CM
INSERM Unité 338, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France.
Haïk
Stéphane
S
Faucheux
Baptiste A
BA
Metz-Boutigue
Marie-Helène
MH
Fierville
Françoise
F
Fuchs
Jean-Paul
JP
Hauw
Jean-Jacques
JJ
Aunis
Dominique
D
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism / Q000473:pathology; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism*; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D016501:Neurites / Q000473:pathology; D058225:Plaque, Amyloid / Q000378:metabolism* / Q000473:pathology; D011328:Prions / Q000378:metabolism*; D013702:Temporal Lobe / Q000378:metabolism / Q000473:pathology
D016229:Amyloid beta-Peptides; D053379:Chromogranin A; D002864:Chromogranins; D011328:Prions