title: Localization of age-associated white matter hyperintensities in late-life depression.
abstract: OBJECTIVE
  Deep white matter hyperintense lesions are associated with advanced age and late-life depression. The authors examined where age-related cerebral lesions occurred in elderly depressed and healthy control subjects.
  
  
  METHODS
  Eighty-seven depressed subjects and 47 control subjects underwent 1.5 T cranial magnetic resonance imaging (MRI). Utilizing a semiautomated method, a segmented image was created containing only white matter lesions. We created a statistical parametric map (SPM) separately for each subject group that displayed the association between lesions in any voxel and advanced age.
  
  
  RESULTS
  The SPM analysis in depressed subjects demonstrates a significant association between age and lesions found in bilateral, frontal, and left parietal regions. The analysis in control subjects found significant associations only in bilateral parieto-temporal regions, not frontal regions.
  
  
  CONCLUSIONS
  This study demonstrates a different pattern of age-related lesion location between depressed and control subjects. It further supports the theory that frontostriatal disconnection contributes to late-life depression.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA. taylo066@mc.duke.edu
authors.forename: Warren D
authors.initials: WD
authors.lastname: Taylor
authors.forename: James R
authors.initials: JR
authors.lastname: MacFall
authors.forename: David C
authors.initials: DC
authors.lastname: Steffens
authors.forename: Martha E
authors.initials: ME
authors.lastname: Payne
authors.forename: James M
authors.initials: JM
authors.lastname: Provenzale
authors.forename: K Ranga Rama
authors.initials: KR
authors.lastname: Krishnan
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003865:Major Depressive Disorder / Q000473:pathology* / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D017397:Prefrontal Cortex / Q000473:pathology*