title: Comparison of Alzheimer's disease risk factors in white and African American families.
abstract: The associations between alcohol, smoking, and head injury and the risk of AD in 443 African American and 2,336 white participants in the MIRAGE Study were evaluated. Alcohol had a modest protective effect in whites (odds ratio [OR] = 0.82, 95% CI = 0.68 to 0.99), with a similar trend in African Americans (OR = 0.88, 95% CI = 0.54 to 1.4). Head trauma increased the risk of AD in whites (OR = 2.3, 95% CI = 1.8 to 3.0) and African Americans (OR = 2.9, 95% CI = 1.2 to 7.0). Smoking was not associated with AD risk in whites (OR = 0.88, 95% CI = 0.73 to 1.1) or African Americans (OR = 1.0, 95% CI = 0.69 to 1.5). These risks were similar across subsets stratified by the presence or absence of the APOE epsilon4 allele.
authors.affiliation: Department of Medicine, Medical University of South Carolina, Charleston, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Bachman
authors.forename: R C
authors.initials: RC
authors.lastname: Green
authors.forename: K S
authors.initials: KS
authors.lastname: Benke
authors.forename: L A
authors.initials: LA
authors.lastname: Cupples
authors.forename: L A
authors.initials: LA
authors.lastname: Farrer
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000428:Alcohol Drinking / Q000208:ethnology; D000544:Alzheimer Disease / Q000208:ethnology* / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics; D044383:Black People / Q000235:genetics / Q000706:statistics & numerical data*; D006259:Craniocerebral Trauma / Q000208:ethnology; D004198:Disease Susceptibility; D004522:Educational Status; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000208:ethnology; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics / Q000706:statistics & numerical data*; D001741:Black or African American
chemical_list: D001057:Apolipoproteins E