title: Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain.
abstract: Four positive modulators of AMPA-type glutamate receptors (cyclothiazide, CX614, LY404187 and S18986-1) given in acute or chronic manner exerted a neuroprotective effect in lesions induced in postnatal day 5 (P5) mice by intracerebral injection of ibotenate, an NMDA agonist. The neuroprotective effects were mediated via the MAPK pathway since coinjection of the MEK inhibitor, PD98059, blocked the neuroprotective effects. Administration of CX614 to neonatal mice was followed by upregulation of hippocampal and cortical BDNF expression.
authors.affiliation: INSERM E9935, Hôpital Robert Debré, Paris, France.
authors.forename: Eleni
authors.initials: E
authors.lastname: Dicou
authors.forename: Claire-Marie
authors.initials: CM
authors.lastname: Rangon
authors.forename: Fabien
authors.initials: F
authors.lastname: Guimiot
authors.forename: Michael
authors.initials: M
authors.lastname: Spedding
authors.forename: Pierre
authors.initials: P
authors.lastname: Gressens
mesh_terms: D000494:Allosteric Regulation / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018091:Receptors, AMPA / Q000819:agonists* / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists* / Q000502:physiology
chemical_list: D018690:Excitatory Amino Acid Agonists; D018696:Neuroprotective Agents; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate