Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione.
L-Cysteine-glutathione disulfide, a ubiquitous substance present in mammalian cells, was shown to be highly effective in protecting mice against acetaminophen-induced hepatotoxicity. Since the corresponding D-cysteine-glutathione disulfide was totally ineffective in this regard, an enzymatic mechanism that provides glutathione directly to cells is postulated.
Berkeley
Lorelle I
LI
Medical Research Laboratories, DVA Medical Center, Minneapolis, MN 55417, USA.
Cohen
Jonathan F
JF
Crankshaw
Daune L
DL
Shirota
Frances N
FN
Nagasawa
Herbert T
HT
D000082:Acetaminophen / Q000037:antagonists & inhibitors / Q000633:toxicity; D000111:Acetylcysteine / Q000494:pharmacology; D018712:Analgesics, Non-Narcotic / Q000037:antagonists & inhibitors / Q000633:toxicity; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D005978:Glutathione / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D011355:Prodrugs / Q000494:pharmacology*
D018712:Analgesics, Non-Narcotic; D016166:Free Radical Scavengers; D011355:Prodrugs; D000082:Acetaminophen; C031586:cysteine-glutathione disulfide; D005978:Glutathione; D003545:Cysteine; D000111:Acetylcysteine