Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study.
OBJECTIVE
To examine the association between hypertensive diseases of pregnancy (gestational hypertension and pre-eclampsia) and the development of circulatory diseases in later life.


METHODS
Cohort study of women who had pre-eclampsia during their first singleton pregnancy. Two comparison groups were matched for age and year of delivery, one with gestational hypertension and one with no history of raised blood pressure.


METHODS
Maternity services in the Grampian region of Scotland.


METHODS
Women selected from the Aberdeen maternity and neonatal databank who were resident in Aberdeen and who delivered a first, live singleton from 1951 to 1970.


METHODS
Current vital and cardiovascular health status ascertained through postal questionnaire survey, clinical examination, linkage to hospital discharge, and mortality data.


RESULTS
There were significant positive associations between pre-eclampsia/eclampsia or gestational hypertension and later hypertension in all measures. The adjusted relative risks varied from 1.13-3.72 for gestational hypertension and 1.40-3.98 for pre-eclampsia or eclampsia. The adjusted incident rate ratio for death from stroke for the pre-eclampsia/eclampsia group was 3.59 (95% confidence interval 1.04 to 12.4).


CONCLUSIONS
Hypertensive diseases of pregnancy seem to be associated in later life with diseases related to hypertension. If greater awareness of this association leads to earlier diagnosis and improved management, there may be scope for reducing a proportion of the morbidity and mortality from such diseases.
Wilson
Brenda J
BJ
Department of Public Health, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD.
Watson
M Stuart
MS
Prescott
Gordon J
GJ
Sunderland
Sarah
S
Campbell
Doris M
DM
Hannaford
Philip
P
Smith
W Cairns S
WC
D000328:Adult; D000367:Age Factors; D016009:Chi-Square Distribution; D015331:Cohort Studies; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000401:mortality; D016017:Odds Ratio; D011225:Pre-Eclampsia / Q000150:complications* / Q000401:mortality; D011247:Pregnancy; D012307:Risk Factors; D012606:Scotland / Q000453:epidemiology; D012923:Social Class; D020521:Stroke / Q000209:etiology* / Q000401:mortality