title: Biological factors and therapeutic modulation in brain tumor radiotherapy.
abstract: Diagnosticotherapeutic approaches aimed at the improvement of prognosis of the most aggressive brain tumors tend to include new tools of investigation. Functional imaging, biologic markers, radiosensitizers, the combination of different modalities of radiation therapy and chemotherapy are being experimented. These new approaches to the neoplastic metabolism require increased resources and a close follow-up during treatment to better define the biological target volume. More sophisticated and aggressive techniques as intensity modulated radiation therapy or brachycurietherapy can be suitably included in combined modality therapy.
authors.affiliation: Cattedra di Radioterapia, Istituto di Radiologia, Università Cattolica del S. Cuore, Policlinico A. Gemelli, Largo A. Gemelli 8, 00168 Roma, Italy. dhrtp@rm.unicatt.it
authors.forename: Mario
authors.initials: M
authors.lastname: De Santis
authors.forename: Adolfo
authors.initials: A
authors.lastname: Caiazza
authors.forename: Andrea
authors.initials: A
authors.lastname: Simili
mesh_terms: D001685:Biological Factors; D001918:Brachytherapy; D001932:Brain Neoplasms / Q000532:radiotherapy*; D017024:Chemotherapy, Adjuvant; D006801:Humans; D011838:Radiation-Sensitizing Agents; D011879:Radiotherapy Dosage
chemical_list: D001685:Biological Factors; D011838:Radiation-Sensitizing Agents