title: Modulation of the natriuretic peptide system in heart failure: from bench to bedside?
abstract: Since the discovery of atrial natriuretic peptide, the unravelling of the natriuretic peptide system has been a story of scientific success. However, bridging the gap between bench and bedside has proved difficult, and as yet has not provided any major clinical progress. In this review we will first give a detailed outline of the key elements constituting the natriuretic peptide system. Secondly, we will briefly explain the underlying rationale, basic concepts and evidence behind currently pursued strategies to potentiate the natriuretic peptide system. Thirdly, we will highlight some of the problems that have so far hindered successful translation of these theoretically viable treatment options into tangible clinical progress.
authors.affiliation: Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Academic Avenue, Cardiff CF14 4XN, UK. matthschmitt@doctors.org.uk
authors.forename: Matthias
authors.initials: M
authors.lastname: Schmitt
authors.forename: John R
authors.initials: JR
authors.lastname: Cockcroft
authors.forename: Michael P
authors.initials: MP
authors.lastname: Frenneaux
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology; D002316:Cardiotonic Agents / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D051379:Mice; D020097:Natriuretic Peptide, Brain / Q000502:physiology; D020098:Natriuretic Peptide, C-Type / Q000502:physiology; D036361:Peptide Hormones / Q000502:physiology* / Q000627:therapeutic use
chemical_list: D002316:Cardiotonic Agents; D036361:Peptide Hormones; D020097:Natriuretic Peptide, Brain; D020098:Natriuretic Peptide, C-Type; D009320:Atrial Natriuretic Factor