title: Primary pulmonary pleomorphic adenoma. An immunohistochemical study and review of the literature.
abstract: Primary pleomorphic adenoma of the lung is an uncommon condition. We present a case of primary pulmonary pleomorphic adenoma and its immunohistologic features. The presence of immunoreactivity to both anticytokeratin and antivimentin antibodies for its epithelial components is suggestive of a primary pulmonary lesion. Its high proliferation index and its immunoreactivity to tumor regulatory gene p16(INK4A) are features that, to our knowledge, have not been reported previously. They may have a role in the frequent recurrence of these tumors many years after their apparently complete excision. Detailed genetic investigation and long-term follow-up of this rare tumor will aid in the characterization of its biologic profile.
authors.affiliation: Department of Cardiothoracic Surgery, Harefield Hospital, United Kingdom.
authors.forename: Keng Leong
authors.initials: KL
authors.lastname: Ang
authors.forename: Venkata Ramana
authors.initials: VR
authors.lastname: Dhannapuneni
authors.forename: William Ellis
authors.initials: WE
authors.lastname: Morgan
authors.forename: Irshad Nabi
authors.initials: IN
authors.lastname: Soomro
mesh_terms: D008949:Adenoma, Pleomorphic / Q000737:chemistry / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D007633:Keratins / Q000032:analysis / Q000276:immunology; D008175:Lung Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D008875:Middle Aged; D014746:Vimentin / Q000032:analysis / Q000276:immunology
chemical_list: D014746:Vimentin; D007633:Keratins