title: Effects of childhood bronchiectasis on cardiac functions.
abstract: BACKGROUND
  Bronchiectasis is still a widespread disease in developing countries. It is an important cause of mortality and morbidity. The information on cardiac involvement in bronchiectasis is limited. However, cor pulmonale is common in patients with chronic lung disease, such as cystic fibrosis.
  
  
  METHODS
  We utilized echocardiography and exercise tests, along with clinical scoring, chest radiograph scoring, and pulmonary function tests in 21 patients to determine whether detectable changes in cardiac functions were present, and the nature of their relationship to the underlying disease severity.
  
  
  RESULTS
  The ventricular systolic functions were preserved in all patients. Some of the patients had changes in left ventricular diastolic function indices, characterized by abnormal Ewave/Awave (E/A) ratios or isovolumetric relaxation time values. Isovolumetric relaxation time but not E/A ratios was found to have a significant negative correlation with the clinical score. In addition, exercise capacity was decreased in bronchiectatic children. Most of the patients stopped the exercise test due to exhaustion before reaching maximum heart rate.
  
  
  CONCLUSIONS
  Left ventricular diastolic functions are affected in bronchiectasis, and the performance of patients is dependent on their pulmonary status. This is the first study demonstrating the cardiac effects of bronchiectasis according to our survey of the published literature.
authors.affiliation: Division of Pediatric Cardiology, Marmara University School of Medicine, Istanbul, Turkey. figenakalin@superonline.com
authors.forename: Figen
authors.initials: F
authors.lastname: AkalIn
authors.forename: Tolga F
authors.initials: TF
authors.lastname: Köroglŭ
authors.forename: Serap
authors.initials: S
authors.lastname: Bakaç
authors.forename: Elif
authors.initials: E
authors.lastname: Dagli
mesh_terms: D000293:Adolescent; D001987:Bronchiectasis / Q000503:physiopathology*; D002648:Child; D003971:Diastole / Q000502:physiology; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008297:Male; D012129:Respiratory Function Tests; D013599:Systole / Q000502:physiology; D016277:Ventricular Function, Left