A case of cardiac localization of graft-versus-host disease after allogenic bone marrow transplantation.
A 29-year-old male developed symptoms and signs of heart failure shortly after allogenic bone marrow transplantation for chronic myelogenous leukemia. Echocardiographic evaluation showed left ventricular wall thickening, a left ventricular restrictive filling pattern and pericardial effusion. Cardiac magnetic resonance revealed nodular areas compatible with lymphocyte infiltration. The hypothesis of cardiac graft-versus-host disease was supported by the reversibility of all the abnormalities after specific treatment.
Cereda
Manuela
M
Cardiothoracic Department, Division of Cardiology, University of Milan-Bicocca, San Gerardo Hospital, Monza, MI, Italy.
Trocino
Giuseppe
G
Pogliani
Enrico Maria
EM
Schiavina
Riccardo
R
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000379:methods; D003520:Cyclophosphamide / Q000008:administration & dosage; D015150:Echocardiography, Doppler; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000209:etiology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000628:therapy*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010490:Pericardial Effusion / Q000175:diagnosis* / Q000209:etiology; D018570:Risk Assessment; D012720:Severity of Illness Index; D014184:Transplantation, Homologous; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology
D003520:Cyclophosphamide