title: Hemodynamic segmentation of MR brain perfusion images using independent component analysis, thresholding, and Bayesian estimation.
abstract: Dynamic-susceptibility-contrast MR perfusion imaging is a widely used imaging tool for in vivo study of cerebral blood perfusion. However, visualization of different hemodynamic compartments is less investigated. In this work, independent component analysis, thresholding, and Bayesian estimation were used to concurrently segment different tissues, i.e., artery, gray matter, white matter, vein and sinus, choroid plexus, and cerebral spinal fluid, with corresponding signal-time curves on perfusion images of five normal volunteers. Based on the spatiotemporal hemodynamics, sequential passages and microcirculation of contrast-agent particles in these tissues were decomposed and analyzed. Late and multiphasic perfusion, indicating the presence of contrast agents, was observed in the choroid plexus and the cerebral spinal fluid. An arterial input function was modeled using the concentration-time curve of the arterial area on the same slice, rather than remote slices, for the deconvolution calculation of relative cerebral blood flow.
authors.affiliation: Institute of Radiological Science, National Yang-Ming University, Taipei, Taiwan, ROC.
authors.forename: Yi-Hsuan
authors.initials: YH
authors.lastname: Kao
authors.forename: Wan-Yuo
authors.initials: WY
authors.lastname: Guo
authors.forename: Yu-Te
authors.initials: YT
authors.lastname: Wu
authors.forename: Kuo-Ching
authors.initials: KC
authors.lastname: Liu
authors.forename: Wen-Yen
authors.initials: WY
authors.lastname: Chai
authors.forename: Chiao-Yuan
authors.initials: CY
authors.lastname: Lin
authors.forename: Yi-Shuan
authors.initials: YS
authors.lastname: Hwang
authors.forename: Adrain
authors.initials: A
authors.lastname: Jy-Kang Liou
authors.forename: Hsiu-Mei
authors.initials: HM
authors.lastname: Wu
authors.forename: Hui-Cheng
authors.initials: HC
authors.lastname: Cheng
authors.forename: Tzu-Chen
authors.initials: TC
authors.lastname: Yeh
authors.forename: Jen-Chuen
authors.initials: JC
authors.lastname: Hsieh
authors.forename: Michael
authors.initials: M
authors.lastname: Mu Huo Teng
mesh_terms: D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011336:Probability