title: Supranuclear gaze palsy and opsoclonus after Diazinon poisoning.
abstract: A 52 year old man developed a supranuclear gaze palsy and opsoclonus after Diazinon poisoning. The diagnosis was confirmed by low plasma and red blood cell cholinesterase activity and urine mass spectroscopy. Saccadic control may be mediated in part by acetylcholine. Opsoclonus in the setting of organophosphate intoxication may occur as a result of cholinergic excess which overactivates the fastigial nuclei.
authors.affiliation: Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. liangtw@msn.com
authors.forename: T-W
authors.initials: TW
authors.lastname: Liang
authors.forename: L J
authors.initials: LJ
authors.lastname: Balcer
authors.forename: D
authors.initials: D
authors.lastname: Solomon
authors.forename: S R
authors.initials: SR
authors.lastname: Messé
authors.forename: S L
authors.initials: SL
authors.lastname: Galetta
mesh_terms: D003976:Diazinon / Q000506:poisoning*; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D008875:Middle Aged; D015835:Ocular Motility Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D013494:Supranuclear Palsy, Progressive / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
chemical_list: D007306:Insecticides; D003976:Diazinon