title: Epidemiology of Esophagus, Lung and Breast Cancer in Mountainous Regions of Kyrgyz Republic.
abstract: Relative incidences of esophagus, lung and breast cancers differ in the various populations in Kyrgyzstan. Esophagus cancer is the most commonly observed among the Turkic groups, especially in Kazakhs, while lung and breast cancer are frequently encountered among the European representatives of the population - Russians in particular. Fluctuation in rates for these cancer forms in the Kyrgyzstan mountain regions is highly dependable on the height above sea level. One potential major factor, which may account for the low cancer frequency in general and influence esophagus, lung and breast cancer forms in particular - is mountain hypoxia. Since, among the native citizens (Kyrgyzes), which are adapted to mountain hypoxia conditions (population adaptation), the indicated cancer forms are not so often than the same forms appearance among the other ethnical groups (long adaptation), especially newcoming ones. Thus, the incidence rates of esophageal cancer in the Kazakh population is about 32,3 (per 100,000), the same sickness in Kyrgyz is about 11,3, the figure for lung cancer among the Russian population is 34,8, while among Kyrgyzes it is 11,2, breast cancer incidence in Russian citizens is 34,8 but only15,1 among Kyrgyz residents. It could be established that the studied forms of cancer are less common in high mountain regions than in the regions with low mountains. To a certain extent, mountain hypoxia may function like a brake for the development of cancer tumors. HGowever, the situation is complex, because of, the presence of the other factors entailed by the demographic, social-economic and other variation.
authors.affiliation: Department of Epidemiology and Cancer Statistics, National Center of Oncology under the Public Health Ministry of Kyrgyz Republic. igisinov@netmail.kg
authors.forename: Saginbek
authors.initials: S
authors.lastname: Igisinov
authors.forename: Enverbek
authors.initials: E
authors.lastname: Soodonbekov
authors.forename: Nurbek
authors.initials: N
authors.lastname: Igisinov
authors.forename: Talgat
authors.initials: T
authors.lastname: Subanbaev