Genotype Frequencies of Cyclooxygenease 2 (COX2) Rare Polymorphisms for Japanese with and without Colorectal Cancer.
Cyclooxygenase 2 (COX2) is an inducible enzyme synthesizing prostaglandins from arachidonic acid, which is thought to play an important role in colorectal carcinogenesis. Since the COX2 polymorphisms, if functional, may modify the carcinogenesis pathway, the associations between the reported polymorphisms and colorectal cancer risk were examined in a hospital-based case-control study. Six polymorphisms of the gene encoding COX2 were genotyped for 241 non-cancer individuals (controls) and 148 colorectal cancer patients (74 colon cancer, 73 rectal cancer, and 1 colorectal cancer date, 22 polymorphisms including the above six have been reported for COX2. The other polymorphisms remain to be examined.
Hamajima
Nobuyuki
N
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan nhamajim@aichi-cc.pref. aichi.jp
Takezaki
Toshiro
T
Matsuo
Keitaro
K
Saito
Toshiko
T
Inoue
Manami
M
Hirai
Takashi
T
Kato
Tomoyuki
T
Ozeki
Junko
J
Tajima
Kazuo
K