Morphological manipulation of PC liposome by controlled bolaamphiphile doping.
The morphological characterization of aqueous dispersions of PC amphiphile and bolaamphiphile AEC was observed by transmission electron microscopy, the measurement of the liposomal membrane fluidity, differential scanning calorimetry, 5(6)-CF release from liposome and zeta potential measurement. Results indicate that the bolaamphiphile AEC can be included within conventional egg-PC liposome bilayer, which leads to the decrease of liposomal membrane fluidity (P) and the release behavior of 5(6)-CF. This behavior could be due to the property of bolaamphiphile AEC and the good miscibility of bolaamphiphile AEC with PC.
Aihua
Zou
Z
The Key Laboratory of Molecular and Biomolecular Electronics of Ministry of Education, Southeast University, Nanjing 210096, China. zouaihua@seu.edu.cn
Qiang
Gu
G
Jun
Xu
X
Chunwei
Yuan
Y
D002152:Calorimetry, Differential Scanning; D004563:Electrochemistry; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism; D008560:Membrane Fluidity; D008854:Microscopy, Electron; D010743:Phospholipids / Q000737:chemistry* / Q000378:metabolism; D013501:Surface-Active Agents / Q000737:chemistry* / Q000378:metabolism; D013696:Temperature; D013997:Time Factors
D008081:Liposomes; D010743:Phospholipids; D013501:Surface-Active Agents