title: The effect of the cyclooxygenase blockers, ibuprofen on the development of glomeruli in Sprague-Dawley rats.
abstract: Cyclo-oxygenase mediated prostaglandins are important determinants of glomerular development and kidney function. Ibuprofen inhibit the enzyme cyclo-oxygenase and thereby block the prostaglandin synthesis in the kidneys. Cyclo-oxygenase exist in two iso-forms (COX-1 and COX-2). It has ben proposed that Non-steroidal anti-inflammatory drugs (NSAIDs) with preferential COX-2 selectivity have fewer renal side effects than drugs with preferential COX-1 selectivity. The significance of this remains unclear since nephrotoxicity is relatively uncommon with ibuprofen and, when present is usually rapidly reversible although, ibuprofen has a higher potency against COX-1 than COX-2. We therefore investigated the effect of ibuprofen on glomerulogenesis in Sprague-Dawley rats. Ibuprofen (22 mg/kg/day) was administered orally from day 10 of gestation to day 15 after parturition. Light microscopic examination of ibuprofen-treated neonatal kidneys show hypoplastic glomeruli. These results suggest that low dose ibuprofen is deleterious to glomerular development.
authors.affiliation: Department of Anatomy, College of Medicine, University of Lagos, P.M.B. 12003, Lagos, Nigeria.
authors.forename: O
authors.initials: O
authors.lastname: Akinola
authors.forename: C
authors.initials: C
authors.lastname: Noronha
authors.forename: A
authors.initials: A
authors.lastname: Oremosu
authors.forename: O
authors.initials: O
authors.lastname: Kusemiju
authors.forename: O A
authors.initials: OA
authors.lastname: Okanlawon
mesh_terms: D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D005260:Female; D007052:Ibuprofen / Q000009:adverse effects*; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000201:enzymology* / Q000473:pathology; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016861:Cyclooxygenase Inhibitors; D007052:Ibuprofen