Control of triglyceride storage by a WD40/TPR-domain protein.
Obesity is a metabolic disorder related to improper control of energy uptake and expenditure, which results in excessive accumulation of body fat. Initial insights into the genetic pathways that regulate energy metabolism have been provided by a discrete number of obesity-related genes that have been identified in mammals. Here, we report the identification of the adipose (adp) gene, the mutation of which causes obesity in Drosophila. Loss of adp activity promotes increased fat storage, which extends the lifespan of mutant flies under starvation conditions. By contrast, adp gain-of-function causes a specific reduction of the fat body in Drosophila. adp encodes an evolutionarily conserved WD40/tetratricopeptide-repeat-domain protein that is likely to represent an intermediate in a novel signalling pathway.
Häder
Thomas
T
DeveloGen AG, Rudolf-Wissell-Strasse 28, 37079 Göttingen, Germany.
Müller
Sandra
S
Aguilera
Miguel
M
Eulenberg
Karsten G
KG
Steuernagel
Arnd
A
Ciossek
Thomas
T
Kühnlein
Ronald P
RP
Lemaire
Lydia
L
Fritsch
Rüdiger
R
Dohrmann
Cord
C
Vetter
Ingrid R
IR
Jäckle
Herbert
H
Doane
Winifred W
WW
Brönner
Günter
G
D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry; D029721:Drosophila Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics*; D004734:Energy Metabolism / Q000235:genetics; D019143:Evolution, Molecular; D005216:Fat Body / Q000378:metabolism*; D007814:Larva / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D009154:Mutation; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D016415:Sequence Alignment; D014280:Triglycerides / Q000235:genetics / Q000378:metabolism*
D018076:DNA, Complementary; D029721:Drosophila Proteins; D011506:Proteins; D014280:Triglycerides; C490481:adp protein, Drosophila