title: TAP-independent antigen presentation on MHC class I molecules: lessons from Epstein-Barr virus.
abstract: For recognition by CD8(+) lymphocytes, peptides derived from cytosolically processed antigen need to access MHC class I molecules en route to the target cell surface. This normally requires peptide transport into the endoplasmic reticulum via the transporter associated with antigen presentation (TAP) complex. However, as recent work with Epstein-Barr virus illustrates, TAP-independent presentation pathways also exist and are growing in number.
authors.affiliation: Max Delbrueck Centrum for Molecular Medicine, 13125 Berlin, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Lautscham
authors.forename: Alan
authors.initials: A
authors.lastname: Rickinson
authors.forename: Neil
authors.initials: N
authors.lastname: Blake
mesh_terms: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000502:physiology; D017951:Antigen Presentation; D000956:Antigens, Viral / Q000276:immunology*; D003546:Cysteine Endopeptidases / Q000378:metabolism; D000939:Epitopes / Q000276:immunology; D019309:Epstein-Barr Virus Nuclear Antigens / Q000378:metabolism; D004854:Herpesvirus 4, Human / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D016753:Interleukin-10 / Q000378:metabolism; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D014763:Viral Matrix Proteins / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; D000956:Antigens, Viral; C066460:BCRF1 protein, Human herpesvirus 4; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D000939:Epitopes; D019309:Epstein-Barr Virus Nuclear Antigens; D015395:Histocompatibility Antigens Class I; D009097:Multienzyme Complexes; C073119:TAP1 protein, human; D014763:Viral Matrix Proteins; D014764:Viral Proteins; D016753:Interleukin-10; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; C417029:EBV-encoded nuclear antigen 1