Lithium carbonate 24-hour extended-release capsule filled with 6 mm tablets.
A 24-h extended-release multiparticulate capsule containing a dose of 500 mg of lithium carbonate divided into 6 tablets 6 mm in size was produced. In order to achieve an immediate and prolonged drug release profile one uncoated tablet and 5 tablets coated with methacrylic acid/ethyl acrylate copolymer Kollicoat MAE30DP were filled into a capsule. The core of tablets consisted of microcrystalline cellulose, lactose, povidone, macrogol and magnesium stearate.
Pietkiewicz
P
P
Department of Pharmaceutical Technology, Medical University, Gdansk, Poland.
Sznitowska
M
M
Dorosz
A
A
Lukasiak
J
J
D018692:Antimanic Agents / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations; D016651:Lithium Carbonate / Q000008:administration & dosage* / Q000737:chemistry; D013607:Tablets
D018692:Antimanic Agents; D003692:Delayed-Action Preparations; D013607:Tablets; D016651:Lithium Carbonate