Inflammation, endothelial dysfunction, and the risk of high blood pressure: epidemiologic and biological evidence.
In spite of its high impact on cardiovascular and renal disease, knowledge on risk factors for the development of high blood pressure (HBP) is limited. Mild chronic inflammation may play a significant role in the incidence of HBP. A persistent low-grade inflammation state could be associated with high but within the 'normal range' cytokine plasma concentration. By impairing the capacity of the endothelium to generate vasodilating factors, particularly nitric oxide (NO), elevated cytokines may lead to the development of endothelial dysfunction, chronic impaired vasodilation, and HBP. These alterations in the L-arginine : NO pathway may play a major role in the development of HBP in young subjects, with inflammation-related alterations in the production of cyclo-oxygenase-derived vasoconstrictors becoming more prominent with advanced age. Cross-sectional independent associations between HBP and plasma levels of C-reactive protein, interleukin-6, and tissue necrosis factor alpha have been reported, but no prospective evidence of these associations is currently available.
Bautista
L E
LE
Department of Preventice Medicine & Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. lbautista@usuhs.mil
D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000503:physiopathology*; D007249:Inflammation / Q000453:epidemiology / Q000503:physiopathology*; D015995:Prevalence; D012307:Risk Factors; D014481:United States / Q000453:epidemiology