title: Off-pump coronary artery bypass grafting. The 1st Medical Faculty of Charles University study.
abstract: OBJECTIVE
  To explore the surgical technique, anaesthesiological management, immediate and mid-term results, graft patency and effectiveness of less invasive coronary artery bypass grafting through a median sternotomy.
  
  
  METHODS
  From January 1998 through December 1999, 144 patients had coronary artery bypass grafting (CABG) without cardiopulmonary bypass (CPB) done by one surgeon through a median sternotomy. The cohort of 107 men and 37 women averaged 60.8 years, mean ejection fraction (EF) was 51.8%. An average of 2.7 (range 1 to 5) grafts/patients was achieved. Results are compared with a CPB subgroup of patients operated on through a median sternotomy in the same time (N = 234). In a random subgroup of 100 patients (50 per group) an angiographic control of graft patency was done.
  
  
  RESULTS
  A non-CPB group showed less postoperative acute myocardial infarction (0.7% vs. 3.8%, p < 0.05) and atrial fibrillation (14.6% vs. 26%, p < 0.05), lower incidence of renal (2.8% vs. 5.1%, p < 0.05) and respiratory complications (2.0% vs. 3.8%, NS). We observed lower operative mortality (0.7% vs. 3.4%, p < 0.05), as well as the occurrence of low cardiac output syndrome (0.7% vs. 5.6%, p < 0.05) in the off-pump group. The follow-up is 36 +/- 12 months and the number of patients with recurrent angina, late AMI and late death is acceptable. We did not find an inordinate number of vein grafts occlusions (0.7% vs. 1.8%, NS) and stenoses (6.6% vs. 6.7%, NS) at anastomotic sites. None of the arterial grafts in both groups were occluded.
  
  
  CONCLUSIONS
  There was little known about the efficacy of the less invasive coronary artery bypass grafting at the beginning of our study. Starting with pioneering the operative technique, we have discovered and proposed three types of a heart verticalization and a reusable stabilizing device. We detected lower incidence of postoperative complications and decreased operative mortality in a non-CPB group. Angiographic assessment displayed an excellent run-off in both groups of patients. Off-pump coronary bypass grafting is associated with sufficient short-term graft patency and mid-term clinical outcomes.
authors.affiliation: Dept. of Cardiovasc. Surg., Charles University Teaching Hospital, 1st Medical Faculty, U nemocnice 2, 12800, Prague 2, Czech Republic, semrad@post.cz
authors.forename: M
authors.initials: M
authors.lastname: Semrád
authors.forename: P
authors.initials: P
authors.lastname: Bodlák
authors.forename: M
authors.initials: M
authors.lastname: Stríteský
authors.forename: J
authors.initials: J
authors.lastname: Kristof
authors.forename: J
authors.initials: J
authors.lastname: Lindner
authors.forename: T
authors.initials: T
authors.lastname: Urban
authors.forename: V
authors.initials: V
authors.lastname: Vondrácek
authors.forename: I
authors.initials: I
authors.lastname: Vanĕk
mesh_terms: D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D014654:Vascular Patency