Flumazenil-induced ballism.
Flumazenil, an imidazobenzodiazepine, is the first benzodiazepine antagonist and is being used to reverse the adverse pharmacological effects of benzodiazepine. There have been a few reports on the central nevous system side effects with its use. We report a patient with generalized ballism following administration of flumazenil. The mechanism through which flumazenil induced this symptom is unknown. It is conceivable that flumazenil may antagonize the GABA-benzodiazepine receptor complex and induce dopamine hypersensitivity, thus induce dyskinesic symptoms.
Kim
Joong-Seok
JS
Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea. ks1007@cmc.cuk.ac.kr
Ko
Seok-Bum
SB
Choi
Yeong-Bin
YB
Lee
Kwang-Soo
KS
D003937:Diagnosis, Differential; D020820:Dyskinesias / Q000209:etiology*; D005260:Female; D005442:Flumazenil / Q000009:adverse effects*; D018757:GABA Modulators / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged
D018757:GABA Modulators; D005442:Flumazenil