title: Diastereoselective synthesis of piperazines by manganese-mediated reductive cyclization.
abstract: A simple and effective synthesis of trans aryl-substituted piperazines using a Brønsted acid and manganese(0) is described. [reaction: see text]
authors.affiliation: Department of Chemistry, University of Utah, 315 S. 1400 East, Salt Lake City, UT 84112-8500, USA.
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Mercer
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Sigman
mesh_terms: D003500:Cyclization; D019281:Dimerization; D007097:Imines / Q000737:chemistry; D008345:Manganese / Q000737:chemistry*; D010084:Oxidation-Reduction; D010879:Piperazines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D007097:Imines; D010879:Piperazines; D008345:Manganese