The interaction of space flight and thyroid state on somatic and skeletal muscle growth and myosin heavy chain expression on neonatal rodents.
The goal of this research project was to determine how the absence of gravity, when imposed at critical stages (post birth day 7 and 14) in the developmental scheme of the neonatal rodent, impacts body and skeletal muscle growth, as well as expression of the myosin heavy chain (MHC) gene family of motor proteins, which are involved in the regulation of muscle contraction.
Adams
G R
GR
Department of Physiology and Biophysics, University of California, Irvine, California 92697-4560, USA.
Haddad
F
F
Baldwin
K M
KM
D000818:Animals; D000831:Animals, Newborn; D018507:Gene Expression Regulation, Developmental; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D018656:Muscle Fibers, Fast-Twitch / Q000502:physiology; D018657:Muscle Fibers, Slow-Twitch / Q000502:physiology; D018482:Muscle, Skeletal / Q000254:growth & development / Q000502:physiology*; D018995:Myosin Heavy Chains / Q000235:genetics*; D051381:Rats; D013026:Space Flight; D013963:Thyroid Hormones / Q000172:deficiency*; D016474:Weight-Bearing; D014893:Weightlessness
D013963:Thyroid Hormones; D007334:Insulin-Like Growth Factor I; D018995:Myosin Heavy Chains