title: [HLA typing in twins with vesicoureteral reflux].
abstract: We treated 2 cases of vesicoureteral reflux (VUR) in twins. Case 1: A 6-year-old girl had grade 3 VUR on the right side and grade 1 VUR on the left side. Case 2: A 5-year-old girl, the younger sister of case 1, had grade 4 VUR on the right side. We treated these patients with bilateral anti-reflux-therapy (Cohen's method). We analyzed the HLA ABC locus in this family and found that these twins and their mother (who had been treated for bilateral VUR in childhood) were of the same haplotype, but not a haplotype previously reported. We believe that familial VUR should be aggressively investigated.
authors.affiliation: Department of Urology, Kinki University of Medicine.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nose
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hanai
authors.forename: Takahide
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Kurita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kajikawa
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Kataoka
mesh_terms: D002648:Child; D002675:Child, Preschool; D004200:Diseases in Twins; D005192:Family Health; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D014429:Twins, Dizygotic; D014718:Vesico-Ureteral Reflux / Q000235:genetics* / Q000601:surgery
chemical_list: D006680:HLA Antigens