[Churg-Strauss syndrome with alveolar hemorrhage].
A 35 year-old man was admitted to our hospital because of cough, wheezing, and paresthesia of the right upper extremity. He demonstrated marked eosinophilia, bronchial asthma, and mononeuritis multiplex. We diagnosed Churg-Strauss syndrome. Serum MPO-ANCA was elevated to 189 U/ml. Chest high-resolution computed tomography showed panlobular ground-glass attenuation in both lungs. BALF showed bloody fluid, and TBLB revealed findings consistent with eosinophilic pneumonia. Lung biopsy by VATS revealed eosinophilic pneumonia, pulmonary vasculitis, capillaritis, and hemosiderosis. The patient recovered after treatment with prednisolone and cyclophosphamide. We concluded that alveolar hemorrhage due to pulmonary capillaritis could be a complication in cases of Churg-Strauss syndrome.
Matsushima
Hidekazu
H
Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, 1696 Itai, Kohnan, Ohsato, Saitama, Japan.
Takayanagi
Noboru
N
Ubukata
Mikio
M
Tokunaga
Daidou
D
Sato
Nagato
N
Kurashima
Kazuyoshi
K
Yanagisawa
Tsutomu
T
Sugita
Yutaka
Y
Hoshi
Eishin
E
Kawabata
Yoshinori
Y
Kanazawa
Minoru
M
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002196:Capillaries; D015267:Churg-Strauss Syndrome / Q000150:complications* / Q000175:diagnosis; D006470:Hemorrhage / Q000209:etiology*; D006486:Hemosiderosis / Q000150:complications / Q000473:pathology; D006801:Humans; D008168:Lung / Q000098:blood supply; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D011650:Pulmonary Alveoli; D011657:Pulmonary Eosinophilia / Q000150:complications / Q000473:pathology; D020775:Thoracic Surgery, Video-Assisted; D014657:Vasculitis / Q000150:complications / Q000473:pathology
D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers