title: Influence of maternal immunity on antibody and T-cell response in mice.
abstract: The prevalence of maternal antibodies (Abs) and an immature neonate immune system, which is inclined to a T-helper 2 (Th2) response, are factors that counteract active immunization in early life. In a mouse model, the maternal influence on an active immunization of 2-day-old offspring with Sendai virus (SV) envelope proteins was explored. Maternal immunizations were conducted with the same SV antigen preparation as used for offspring immunization, presented in three different formulations, namely micelles of SV (SV-MIC), Al(OH)(3)-adjuvanted SV-MIC (SV-aluMIC) for Th2 and immune stimulation complex (iscom)-adjuvanted SV (SV-ISC) for Th1. An inversely correlation was found between the immunoglobulin G2a (IgG2a) Abs of the mothers and the interleukin 5 (IL-5) levels of the offspring. Although a maternally derived immunity induced by SV-aluMIC suppressed both B- and T-cell responses of the newborn to SV-ISC immunization, significant priming effects of the neonatal immunization on IgG2a Abs and IFN-gamma levels were recorded after reimmunization at adult age.
authors.affiliation: Department of Virology, National Veterinary Institute, BMC, P.O. Box 585, S-751 23 Uppsala, Sweden. gunilla.blomqvist@sva.se
authors.forename: Gunilla A M
authors.initials: GA
authors.lastname: Blomqvist
authors.forename: Karin
authors.initials: K
authors.lastname: Lövgren-Bengtsson
authors.forename: Bror
authors.initials: B
authors.lastname: Morein
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation; D005260:Female; D007112:Immunity, Maternally-Acquired; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D010253:Respirovirus Infections / Q000276:immunology*; D029082:Sendai virus; D013601:T-Lymphocytes / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D000914:Antibodies, Viral