title: Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure.
abstract: OBJECTIVE
  To evaluate the correlation between progression rate of glaucomatous damage and retrobulbar blood flow in an institutional setting.
  
  
  METHODS
  Retrospective, observational case series.
  
  
  METHODS
  Twenty open-angle glaucoma patients with at least five visual field examinations and progressive damage in at least one eye were included in the study. Mean +/- standard deviation follow-up time was 4.3 +/- 1.6 years. As an indicator of progression rate of visual field damage, the angle to a horizontal line of the slope of the regression line of the visual field index mean defect over time was calculated for one randomly selected eye per patient. The association between this angle and intraocular pressure, as well as retrobulbar color Doppler imaging measurements obtained at the beginning of the observation period, was analyzed by a multiple linear regression analysis in a stepwise forward approach.
  
  
  RESULTS
  With a faster rate in progression of glaucomatous damage, a lower baseline end diastolic blood flow velocity in the central retinal artery (partial r = -.63; P <.0037) and a higher baseline intraocular pressure (partial r =.59; P <.0078) were noted (multiple r =.69; P <.0043). Rate of progression was not related to the extent of preexisting visual field damage.
  
  
  CONCLUSIONS
  Independent of the extent of glaucomatous damage and intraocular pressure, the progression rate of glaucomatous visual field damage statistically correlates with retrobulbar hemodynamic variables.
authors.affiliation: University Eye Clinic, Basel, Switzerland.
authors.forename: Mücahit
authors.initials: M
authors.lastname: Satilmis
authors.forename: Selim
authors.initials: S
authors.lastname: Orgül
authors.forename: Barbara
authors.initials: B
authors.lastname: Doubler
authors.forename: Josef
authors.initials: J
authors.lastname: Flammer
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001775:Blood Circulation; D001783:Blood Flow Velocity; D019842:Ciliary Arteries / Q000000981:diagnostic imaging / Q000502:physiology; D018450:Disease Progression; D005260:Female; D005902:Glaucoma, Open-Angle / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging / Q000502:physiology; D009915:Orbit / Q000098:blood supply*; D012161:Retinal Artery / Q000000981:diagnostic imaging / Q000502:physiology; D012189:Retrospective Studies; D018615:Ultrasonography, Doppler, Color; D014794:Visual Fields
chemical_list: D000959:Antihypertensive Agents