title: Valanimycin biosynthesis: investigations of the mechanism of isobutylhydroxylamine incorporation.
abstract: [reaction: see text] The incorporation of [(15)N, (18)O]-isobutylhydroxylamine into the antibiotic valanimycin by Streptomyces viridifaciens has been shown to proceed with loss of the (18)O label, thereby demonstrating that the azoxy oxygen atom of valanimycin is not derived from the oxygen atom of isobutylhydroxylamine.
authors.affiliation: Department of Chemistry MS65, Rice University, 6100 Main St., Houston, Texas 77005, USA.
authors.forename: Tao
authors.initials: T
authors.lastname: Tao
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Alemany
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Parry
mesh_terms: D001391:Azo Compounds / Q000378:metabolism*; D006898:Hydroxylamines / Q000737:chemistry / Q000378:metabolism*; D009587:Nitrogen Isotopes; D010103:Oxygen Isotopes; D013302:Streptomyces / Q000378:metabolism
chemical_list: D001391:Azo Compounds; D006898:Hydroxylamines; D009587:Nitrogen Isotopes; D010103:Oxygen Isotopes; C048267:valanimycin