[Role of cytokines in the development of immunologic and homeostatic disorders in advanced dysplasia and carcinoma of the uterine cervix].
Immunological status, levels of pro-inflammatory cytokines of non-specific resistance and tumor expression factor have been studied in patients with cervical dysplasia or cancer versus stage. Slight and moderate dysplasia involved virtually no changes in interleukin-8 (Il-8) and tumor necrotic factor TNF-alpha concentrations whereas those of Il-1 alpha and Il-1 beta were 5 times as high. Monocyte-dependent expression of tissue factor was similar to that in healthy women. In cases of advanced dysplasia and cervical carcinoma, monocyte-dependent expression of tissue factor and production of Il-1 alpha, Il-1 beta, Il-8 and TNF-alpha were significantly enhanced. Patients with cervical carcinoma stage II and III revealed signs of depression of the cellular component of immunity as well as non-specific resistance. Hence, increased concentrations of cytokines induce monocyte-dependent expression of tissue factor in advanced dysplasia and cervical carcinoma by triggering-on of hypercoaggulation.
Belokrinitskaia
T E
TE
State Medical Academy, Chita.
Vitkovskiĭ
Iu A
IuA
Ponomareva
Iu N
IuN
D000328:Adult; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008875:Middle Aged; D009367:Neoplasm Staging; D019851:Thrombophilia / Q000209:etiology* / Q000378:metabolism; D013925:Thromboplastin / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
D016207:Cytokines; D007375:Interleukin-1; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D013925:Thromboplastin
Rol' tsitokinov v patogeneze narusheniĭ immuniteta i gemostaza u bol'nykh s tiazhëlymi displaziiami i rakom sheĭki matki.