title: Hemoglobin and platelet count effect on platelet yields in plateletpheresis.
abstract: BACKGROUND
  Platelet transfusion in thrombocytopenic patients, especially those with marrow failure, remains one of the most important support measures available. Treatment success depends on rational use of platelet transfusion. Platelet yield, reflected in transfused platelet dose, influences platelet recovery in the patient and allows prolonging intervals between transfusions. In this study, our main objective was to identify donor laboratory and clinical factors that showed some influence on platelet yield obtained by apheresis.
  
  
  METHODS
  Healthy donor laboratory and clinical data were analyzed prior to performing plateletpheresis. Platelet yield was quantified after plateletpheresis procedure was concluded in two different ways: a) prefixed volume of 5,000 mL processed, and b) volume determined according to manufacturer recommendations. Age, gender, hemoglobin concentration, platelet and leukocyte count, height, and weight were included as yield-predicting donor variables.
  
  
  RESULTS
  In group A, two variables were significant: donor platelet count and hemoglobin (Hb) concentrations with r = 0.554, and in group B, donor platelet count, Hb concentrations, and volume with r = 0.758.
  
  
  CONCLUSIONS
  Donor platelet count and hemoglobin concentrations influence platelet yield: higher platelet count corresponds to higher yield, while hemoglobin shows an inverse relationship, i.e., the lower the hemoglobin concentrations, the higher the platelet yield.
authors.affiliation: Departamento de Hematología, Hospital de Especialidades Bernardo Sepúlveda, Centro Médico Nacional Siglo XXI, Mexico City, Mexico. susana_g23@yahoo.com.mx
authors.forename: Susana
authors.initials: S
authors.lastname: Guerrero-Rivera
authors.forename: Guillermo
authors.initials: G
authors.lastname: Gutiérrez-Espíndola
authors.forename: Juan O
authors.initials: JO
authors.lastname: Talavera
authors.forename: Luis Antonio
authors.initials: LA
authors.lastname: Meillón-García
authors.forename: Martha
authors.initials: M
authors.lastname: Pedraza-Echevarría
authors.forename: Javier
authors.initials: J
authors.lastname: Pizzuto-Chávez
mesh_terms: D000293:Adolescent; D000328:Adult; D001781:Blood Component Removal / Q000295:instrumentation; D001782:Blood Donors; D001792:Blood Platelets; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D000090463:Iron Deficiencies; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D017713:Platelet Transfusion; D010983:Plateletpheresis / Q000379:methods*
chemical_list: D006454:Hemoglobins