Inducible and endothelial constitutive nitric oxide synthase gene polymorphisms in Kawasaki disease.
BACKGROUND
Nitric oxide (NO) is secreted by immune and vascular endothelial cells, and appears to play important roles in the pathophysiology of Kawasaki disease (KD). Thus, genetic variations in NO synthase (NOS) genes may be involved in the development of coronary artery lesions (CAL) in KD.


METHODS
The present study investigated the association of endothelial constitutive NOS (ecNOS) and inducible NOS (iNOS) gene polymorphisms with the development of CAL in KD in a Japanese population.


RESULTS
The genotype distributions of 27-bp tandem repeat polymorphism within intron 4 of ecNOS gene did not show any significant difference between controls and KD patients with or without CAL. In addition, there was no significant association between whole-allele distribution of iNOS gene promoter (penta-repeat CCTTT) polymorphism and KD with or without CAL.


CONCLUSIONS
These results did not support any association of ecNOS and iNOS gene polymorphisms to the development of CAL in KD patients in a Japanese population.
Khajoee
Vahid
V
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. vkhajoee@pediatr.med.kyushu-u.ac.jp
Kariyazono
Hidehiko
H
Ohno
Takuro
T
Ihara
Kenji
K
Mizuno
Yumi
Y
Kusuhara
Koichi
K
Hara
Toshiro
T
D044466:Asian People / Q000235:genetics*; D002648:Child; D003327:Coronary Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007564:Japan; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; D011110:Polymorphism, Genetic; D020080:Tandem Repeat Sequences
C496319:NOS2 protein, human; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III