title: Synthesis of a novel aldehyde: 4-O-methyl-5-formylmethyl-2'-deoxyuridine.
abstract: The synthesis of the blocked nucleoside 3',5'-di-O-p-toluoyl-4-O-methyl-5-formylmethyl-2'-deoxyuridine was accomplishied in eleven steps from gamma-butyrolactone. This aldehyde, which should facilitate the synthesis of nucleosides containing 18F. was converted to the corresponding blocked dithianyl nucleoside, and also to 5-(2,2-difluoroethyl)-substituted derivatives of 2'-deoxyuridine and 2'-deoxycytidine.
authors.affiliation: Abteilung E0300-Radiochemie und Radiopharmakologie, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
authors.forename: Chung-Shan
authors.initials: CS
authors.lastname: Yu
authors.forename: Franz
authors.initials: F
authors.lastname: Oberdorfer
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry; D013936:Thymidine / Q000737:chemistry
chemical_list: C480514:4-O-methyl-5-formylmethyl-2'-deoxyuridine; D000447:Aldehydes; D011355:Prodrugs; D013936:Thymidine; D003857:Deoxyuridine