Management of haemophilia B inhibitor patients with anaphylactic reactions to FIX concentrates.
Allergic reactions to concentrates containing factor IX (FIX) are serious complications in the treatment of haemophilia B patients with inhibitor. We have established a therapeutic protocol for such cases using an initial skin test followed by step-wise infusions of FIX concentrates under hydrocortisone cover. We have successfully treated three patients whose treatment with FIX had been suspended.
Shibata
M
M
Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan.
Shima
M
M
Misu
H
H
Okimoto
Y
Y
Giddings
J C
JC
Yoshioka
A
A
D000707:Anaphylaxis / Q000139:chemically induced*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D002985:Clinical Protocols; D004334:Drug Administration Schedule; D003875:Drug Eruptions / Q000209:etiology; D005164:Factor IX / Q000009:adverse effects* / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D002836:Hemophilia B / Q000188:drug therapy*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D012882:Skin Tests
D000893:Anti-Inflammatory Agents; D005164:Factor IX; D006854:Hydrocortisone