title: Epstein-Barr virus and human herpesvirus 8 coinfection and concomitant extranodal nasal-type NK/T cell lymphoma and Castleman disease: case report.
abstract: We describe a 36-year-old man uninfected with human immunodeficiency virus who had confirmed concurrent infection with Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8) and their respective lymphoproliferative manifestations, nasal-type NK/T cell lymphoma and Castleman disease. Antibodies to HHV-8 and EBV DNA were found in plasma and peripheral blood mononuclear cells. An EBV-positive nasal-type NK/T cell lymphoma infiltrated the splenic red pulp, whereas the white pulp contained HHV-8-positive plasmablasts, as found in Castleman disease.
authors.affiliation: Department of Internal Medicine and Infectious Disease, Hôpital Avicenne, Université Paris-Nord, 93009 Bobigny Cedex, France. claire.larroche@avc.ap-hop-paris.fr
authors.forename: Claire
authors.initials: C
authors.lastname: Larroche
authors.forename: Félix
authors.initials: F
authors.lastname: Agbalika
authors.forename: Hélène
authors.initials: H
authors.lastname: Poirel
authors.forename: Antoine
authors.initials: A
authors.lastname: Martin
authors.forename: Agnès
authors.initials: A
authors.lastname: Gautheret-Dejean
authors.forename: Martine
authors.initials: M
authors.lastname: Raphaël
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000096:biosynthesis; D005871:Castleman Disease / Q000150:complications* / Q000276:immunology / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000276:immunology; D004854:Herpesvirus 4, Human; D019288:Herpesvirus 8, Human; D006801:Humans; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000276:immunology / Q000821:virology; D008297:Male; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000276:immunology
chemical_list: D015703:Antigens, CD