Massive immune hemolysis after non-myeloablative allogeneic peripheral blood stem cell transplantation with minor ABO-incompatibility.
A 35-year-old male, blood group B, Rh(D)+ type, received an allogeneic peripheral blood stem cell (PBSC) transplant after a non-myeloablative regimen of fludarabine and cyclophosphamide for resistant gammadelta cutaneous T-cell lymphoma (CTCL). The donor was his HLA-identical brother, blood group O, Rh(D)+ type. Graft-versus-host disease (GVHD) prophylaxis was performed with cyclosporine alone. On day +8, massive immune hemolysis occurred, followed by acute renal failure. Hemodialysis was performed eight times until recovery of renal function on day +24. The risk of delayed immune hemolysis after non-myeloablative allogeneic PBSC transplantation with minor ABO-incompatibility must be considered.
Noborio
Kaoru
K
Division of Hematology, Department of Medicine, Jichi Medical School, Minamikawachi, Japan.
Muroi
Kazuo
K
Izumi
Tohru
T
Toshima
Masaki
M
Kawano-Yamamoto
Chizuru
C
Otsuki
Tetsuya
T
Nagai
Tadashi
T
Komatsu
Norio
N
Ozawa
Keiya
K
D000017:ABO Blood-Group System / Q000276:immunology*; D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D000328:Adult; D001787:Blood Group Incompatibility / Q000276:immunology*; D006461:Hemolysis / Q000276:immunology*; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000150:complications / Q000628:therapy; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D016692:Receptors, Antigen, T-Cell, gamma-delta; D006435:Renal Dialysis; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous
D000017:ABO Blood-Group System; D016692:Receptors, Antigen, T-Cell, gamma-delta