Acute intermittent porphyria associated with ovarian stimulation. A case report.
BACKGROUND
Induction of ovulation in the course of infertility treatment is increasingly commonplace in the 21st century. As a consequence, it can be expected that previously unrecognized complications of the procedure will be reported.


METHODS
A 36-year-old woman presented with severe pelvic pain and hyponatremia after ovarian stimulation with gonadotropins. After admission with a presumptive diagnosis of ovarian hyperstimulation syndrome, a further family history revealed acute intermittent porphyria. A 24-hour urine collection confirmed the diagnosis.


CONCLUSIONS
Hormonal therapy for induction of ovulation in the course of infertility treatment may precipitate attacks of acute intermittent porphyria. A careful history must be undertaken prior to administration of such hormonal preparations.
Seiden
William B
WB
Department of Internal Medicine, Advocate Medical Group, Nesset Pavilion, 1775 West Ballard Road, Park Ridge, IL 60068, USA.
Kelly
Leo P
LP
Ali
Rafi
R
D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000009:adverse effects*; D006728:Hormones / Q000009:adverse effects*; D006801:Humans; D010062:Ovulation Induction / Q000009:adverse effects*; D017118:Porphyria, Acute Intermittent / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D011247:Pregnancy
D006728:Hormones; D005640:Follicle Stimulating Hormone