title: A new type of C2-symmetric bisphospine ligands with a cyclobutane backbone: practical synthesis and application.
abstract: [reaction: see text] A highly efficient and practical optical resolution of anti-head-to-head racemic coumarin dimer, (+/-)-5, by molecular complexation with TADDOL (6) through hydrogen bonding and a convenient transformation of enantiopure 5 to a new type of C(2)-symmetric bisphosphine ligand (3) have been achieved. The asymmetric induction efficiency of these chiral bisphosphine ligands was evaluated in Pd-catalyzed asymmetric allylic substitution, affording the allylic substitution products in excellent yield (up to 99%) and enantioselectivity (up to 98.9% ee).
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, The People's Republic of China.
authors.forename: Dongbo
authors.initials: D
authors.lastname: Zhao
authors.forename: Kuiling
authors.initials: K
authors.lastname: Ding