Emerging roles for myoglobin in the heart.
Myoglobin (Mb) is an intensely studied hemoprotein that is restricted mainly to the heart and oxidative myofibers in skeletal muscle. Previous physiologic and pharmacologic studies have supported a role for Mb in facilitated oxygen transport or as an oxygen reservoir in striated muscle. Transgenic and gene disruption technologies have been utilized to produce mice that lack Mb. Studies utilizing these transgenic mouse models support the notion that Mb may have multiple, diverse functions in the heart. Future studies using these emerging technologies will further enhance the understanding of the role of Mb and other hemoproteins in cardiovascular biology.
Garry
Daniel J
DJ
Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, TX 75390-8573, USA. daniel.garry@utsouthwestern.edu
Kanatous
Shane B
SB
Mammen
Pradeep P A
PP
D000818:Animals; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D009211:Myoglobin / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure
D009211:Myoglobin