title: [Regional isolated perfusion: also applicable in elderly patients].
abstract: In 3 patients over 75 years of age with a malignancy, limb salvage was achieved through the application of isolated limb perfusion with melphalan with or without tumour necrosis factor alpha: an 82-year-old woman with extensive locoregional melanoma metastases on her lower leg, a 78-year-old woman with a large, ulcerating recurrence of melanoma on her lower leg and an 83-year-old woman with recurrent sarcoma of the lower arm. There were no complications and the women recovered well. Isolated limb perfusion can be effectively and safely used in older patients with irresectable tumours of the extremities, offering them limb salvage for the remainder of their lives.
authors.affiliation: Nederlands Kanker Instituut/Antoni van Leeuwenhoek Ziekenhuis, afd. Chirurgische Oncologie, Plesmanlaan 121, 1066 CX Amsterdam. e.noorda@nki.nl
authors.forename: E M
authors.initials: EM
authors.lastname: Noorda
authors.forename: B C
authors.initials: BC
authors.lastname: Vrouenraets
authors.forename: O E
authors.initials: OE
authors.lastname: Nieweg
authors.forename: B B R
authors.initials: BB
authors.lastname: Kroon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D005121:Extremities; D005260:Female; D006801:Humans; D023821:Limb Salvage / Q000379:methods; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary; D008558:Melphalan / Q000008:administration & dosage*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D012509:Sarcoma / Q000188:drug therapy*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan
vernacular_title: Regionale isolatieperfusie: ook bij bejaarde patiënten goed toepasbaar.