title: Expression of the Na(+)/I(-) symporter in invasive ductal breast cancer.
abstract: The function of the sodium iodide symporter (Na(+)/I(-), (NIS), a membrane protein that mediates iodide transport into cells, is the best described in the thyroid cells. NIS is also found in mammary cells during lactation and in breast carcinoma cells. The aim of this study was evaluation of incidence and grade of NIS expression in invasive ductal breast cancer. Immunohistochemistry using a panel of antibodies against NIS was carried out in surgical paraffin-embedded tissue obtained from 50 patients with invasive ductal breast carcinoma. NIS expression was found in 45 (90%) cases. The demonstration of NIS expression in breast carcinoma cells may provide a novel approach to its diagnosis and treatment.
authors.affiliation: Department of Clinical and Experimental Pathomorphology, Jagiellonian University Medical College, Cracow, Poland.
authors.forename: Lucyna
authors.initials: L
authors.lastname: Rudnicka
authors.forename: Anna
authors.initials: A
authors.lastname: Sińczak
authors.forename: Piotr
authors.initials: P
authors.lastname: Szybiński
authors.forename: Bogdan
authors.initials: B
authors.lastname: Huszno
authors.forename: Jerzy
authors.initials: J
authors.lastname: Stachura
mesh_terms: D001693:Biological Transport, Active; D001943:Breast Neoplasms / Q000378:metabolism*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D027981:Symporters / Q000378:metabolism*; D000099209:Sodium-Iodide Symporters
chemical_list: D027981:Symporters; D000099209:Sodium-Iodide Symporters