Foveal thickness in occult macular dystrophy.
OBJECTIVE
Occult macular dystrophy (OMD) is an inherited macular dystrophy characterized by a progressive macular dysfunction without any visible fundus abnormality. We studied the foveal thickness in patients with OMD using optical coherence tomography (OCT).


METHODS
Observational case series. Foveal thickness by OCT images.


METHODS
Foveal thickness obtained from 22 eyes of 11 patients with OMD was compared with that from 27 eyes of 20 age-matched normal controls.


RESULTS
Mean foveal thickness in the patients group (96.5 +/- 19.5 microm) was significantly thinner than that in the normal controls (133.3 +/- 9.0 microm, P <.0001, Mann-Whitney U test). Eighteen of 22 eyes with OMD had foveal thickness that were thinner than the lower limit of the normal range. There was no statistically significant correlation between the foveal thickness and visual acuity, age, or duration from onset.


CONCLUSIONS
These results demonstrated that there are significant anatomic changes in the macula of patients with OMD.
Kondo
Mineo
M
Department of Ophthalmology, Nagoya University School of Medicine, Japan. kondomi@med.nagoya-u.ac.jp
Ito
Yasuki
Y
Ueno
Shinji
S
Piao
Chang-Hua
CH
Terasaki
Hiroko
H
Miyake
Yozo
Y
D000293:Adolescent; D000328:Adult; D003941:Diagnostic Techniques, Ophthalmological; D004596:Electroretinography; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000473:pathology*; D006801:Humans; D007368:Interferometry; D008027:Light; D008268:Macular Degeneration / Q000175:diagnosis*; D008875:Middle Aged; D014054:Tomography / Q000379:methods; D014792:Visual Acuity