Adulthood in women with Turner syndrome.
Turner syndrome, resulting from a complete or partial absence of one X chromosome, is the most commonly occurring chromosomal abnormality in females. Patients have traditionally been carefully followed in paediatric practice during childhood, but were often discharged to primary care on reaching adulthood. Adults with Turner syndrome are thought to have a reduced life expectancy, mainly due to excess cardiovascular risk, but they may also have multiple comorbidities including hypothyroidism, deafness, osteoporosis and the attendant problems of oestrogen deficiency and infertility. A multidisciplinary approach to focused adult care is needed, with consideration of how to optimise surveillance strategies in these women.
Ostberg
Julia E
JE
Department of Endocrinology, Middlesex Hospital, London, UK. j.ostberg@ucl.ac.uk
Conway
Gerard S
GS
D000328:Adult; D000375:Aging / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000235:genetics; D004700:Endocrine System Diseases / Q000209:etiology / Q000235:genetics; D015914:Estrogen Replacement Therapy; D005260:Female; D005298:Fertility / Q000235:genetics; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000235:genetics; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology / Q000235:genetics; D009369:Neoplasms / Q000209:etiology / Q000235:genetics; D009422:Nervous System Diseases / Q000209:etiology / Q000235:genetics; D010024:Osteoporosis / Q000209:etiology / Q000235:genetics; D010049:Ovarian Diseases / Q000188:drug therapy / Q000235:genetics; D014424:Turner Syndrome / Q000150:complications / Q000401:mortality / Q000503:physiopathology* / Q000523:psychology