title: Consistency of interictal and ictal onset localization using magnetoencephalography in patients with partial epilepsy.
abstract: OBJECTIVE
  The aim of this study was to evaluate the spatial accuracy of interictal magnetoencephalography (MEG) in localizing the primary epileptogenic focus in comparison with alternative MEG-derived estimates such as ictal onset recording or sensory mapping of the periphery where seizures manifest.
  
  
  METHODS
  During this retrospective study of 12 patients with epilepsy who had undergone successful magnetic source (MS) imaging with the aid of a dual 37-channel biomagnetometer as well as simultaneous MEG/electroencephalography (EEG) recordings, ictal events were observed in five patients and quantitative comparisons of interictal spike and ictal seizure onset source localizations were made. In the eight patients who had presented with sensorimotor seizure, source localization of cortical sites concordant with seizure foci was determined using somatosensory functional mapping, and the results were quantitatively compared with interictal spike source localizations. Interictal spike sources demonstrated on MEG localized to the same region as the corresponding ictal event or somatosensory source localizations. The mean distance between the ictal foci and interictal spike sources was 1.1 +/- 0.3 cm. Results of functional somatosensory mapping in patients with sensorimotor seizures demonstrated that seizure sources consistently colocalized with interictal MEG spike sources, with a mean distance of 1.5 +/- 0.4 cm. No systematic directional bias was observed. Interictal sources tended to be tightly clustered, and the mean ellipsoid volume, defined by one standard deviation of the source spatial coordinates, was 1 cm3.
  
  
  CONCLUSIONS
  Interictal spike localizations on MEG were concordant with ictal and, where relevant, functional somatosensory mapping localizations. These findings support the interpretation of interictal spikes on MEG as a useful and effective noninvasive method for localizing primary seizure foci.
authors.affiliation: Department of Radiology, University of California at San Francisco, California, USA.
authors.forename: Lilly
authors.initials: L
authors.lastname: Tang
authors.forename: Mary
authors.initials: M
authors.lastname: Mantle
authors.forename: Paul
authors.initials: P
authors.lastname: Ferrari
authors.forename: Hagen
authors.initials: H
authors.lastname: Schiffbauer
authors.forename: Howard A
authors.initials: HA
authors.lastname: Rowley
authors.forename: Nicholas M
authors.initials: NM
authors.lastname: Barbaro
authors.forename: Mitchel S
authors.initials: MS
authors.lastname: Berger
authors.forename: Timothy P L
authors.initials: TP
authors.lastname: Roberts
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002648:Child; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D012189:Retrospective Studies