An antiviral meliacarpin from leaves of Melia azedarach L.
Bioassay guided purification of the ethyl acetate extract of leaves of Melia azedarach led to the isolation of the limonoid 1-cinnamoyl-3,11-dihydroxymeliacarpin, which showed IC50 values of 6 microM and 20 microM for vesicular stomatitis (VSV) and herpes simplex (HSV-1) viruses, respectively. Its structure was established by spectroscopic methods.
Alché
Laura E
LE
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina.
Ferek
Guillermo Assad
GA
Meo
Milena
M
Coto
Celia E
CE
Maier
Marta S
MS
D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001681:Biological Assay; D018259:Herpesvirus 1, Human / Q000187:drug effects; D036701:Limonins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D031586:Melia azedarach / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
C474472:1-cinnamoyl-3,11-dihydroxymeliacarpin; D000998:Antiviral Agents; D036701:Limonins; D039821:Monoterpenes