title: [Study on the strategy of Japanese encephalitis immunization using live attenuated vaccine combined with inactivated vaccine].
abstract: OBJECTIVE
  Using the advantages of Japanese encephalitis live attenuated and inactivated vaccine, to reduce the rate of immunization reaction and to increase the effect, we conducted a study on the strategy of immunization in Japanese encephalitis using live attenuated vaccine combined with inactivated vaccine.
  
  
  METHODS
  Observing the safety and immune effects of different groups.
  
  
  RESULTS
  Data on side effect showed that the rate of moderate and severe systematic reactions of the group who were inoculated with combined vaccine was 0.73%, with local reaction 1.46% while the combined rate of moderate and severe systematic reaction of the group who were inoculated with inactivated vaccine was 2.8%. Under the detection of serum neutralizing antibody, the GMT rose from 1:1.05 - 1:3.35 before vaccination to 1:47.34 - 1:101.30 after vaccination in the different groups. Neutralizing antibody was detected in 97.67% of the combined group. There was a significant difference by comparing neutralizing antibody seroconversion rate of the combined group with the inactivated group (chi(2) = 3.89, P < 0.05), but no significant difference with attenuated group (chi(2) = 0.74, P > 0.05).
  
  
  CONCLUSIONS
  Results showed that in children who previously had been immunized with two doses of inactivated vaccine, the booster administration of live attenuated vaccine was both effective and safe.
authors.affiliation: Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China.
authors.forename: Fu-bao
authors.initials: FB
authors.lastname: Ma
authors.forename: Li
authors.initials: L
authors.lastname: Zheng
authors.forename: Cheng
authors.initials: C
authors.lastname: Bi
authors.forename: Hong
authors.initials: H
authors.lastname: Tao
authors.forename: Yong-lin
authors.initials: YL
authors.lastname: Zhou
authors.forename: Jin-lin
authors.initials: JL
authors.lastname: Zhang
authors.forename: Fen-yang
authors.initials: FY
authors.lastname: Tang
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
authors.forename: Chun-zao
authors.initials: CZ
authors.lastname: Zheng
authors.forename: Wei-bin
authors.initials: WB
authors.lastname: Peng
authors.forename: Ren-jie
authors.initials: RJ
authors.lastname: Jiang
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D002675:Child, Preschool; D004664:Encephalitis Virus, Japanese / Q000276:immunology; D006801:Humans; D007114:Immunization; D022321:Japanese Encephalitis Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D022321:Japanese Encephalitis Vaccines; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated