title: Gene-environment Interactions and Polymorphism Studies of Cancer Risk in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center II (HERPACC-II).
abstract: Genetic polymorphisms may modify the effects of environmental risk factors on cancer occurrence. We have recently launched a comprehensive epidemiologic project, HERPACC II (Hospital-based Epidemiologic Research Program at Aichi Cancer Center II), including both lifestyle and polymorphism data, following HERPACC-I which solely concentrated on lifestyle data. As of April 2001, about 3000 samples of DNA are being stored to conduct case-control studies. Genotyping of 46 polymorphisms has been conducted at the laboratory of the Division of Epidemiology and Prevention. Twelve case-control studies and two papers on a new PCR method, PCR-CTPP (polymerase chain reaction with confronting two-pair primers), have been accepted for publication. Significant findings in Japanese were found for 1) gene-environment interaction for esophageal cancer between heavy drinking and aldehyde dehydrogenase 2 (ALDH2), 2) malignant lymphoma risk with methylenetetrahydrofalate reductase (MTHFR) and methionine synthase (MS), 3) interactions between smoking and two polymorphisms, interleukin 1B (IL-1B) and myeloperoxidase (MPO) for Helicobacter pylori infection, and 4) smoking habits with dopamine receptor D2 (DRD2) and IL-1B. Further studies on interactions with polymorphisms will continue to be conducted for Japanese, using larger sizes of samples.
authors.affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681 Japan, nhamajim@aichi-cc.pref.aichi.jp
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hamajima
authors.forename: Keitaro
authors.initials: K
authors.lastname: Matsuo
authors.forename: Toshiko
authors.initials: T
authors.lastname: Saito
authors.forename: Kaoru
authors.initials: K
authors.lastname: Hirose
authors.forename: Manami
authors.initials: M
authors.lastname: Inoue
authors.forename: Toshiro
authors.initials: T
authors.lastname: Takezaki
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kuroishi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tajima