[Common variable immunodeficiency--advances in diagnosis, pathogenesis and treatment].
Common variable immunodeficiency (CVI) is one of the most frequent primary immunological disorders. This congenital immunodeficiency, inherited in autosomal recessive way, has not fully elucidated pathogenesis--in spite of over forty years of studies. The cause of the disease seems to be mixed T and B-cell function disorders. Common variable immunodeficiency is characterised by significant variability of symptoms and signs. In the presented paper the definition, basic clinical manifestations of the disease, its course, prognosis are presented, and diagnostic and therapeutic management are discussed. The paper contains also a comprehensive review of current literature presenting modern views on the pathogenesis of CVI, and discussion of CVI variant--Good's syndrome.
Pawliczak
Rafał
R
Katedra i Zakład Immunologii Klinicznej, Uniwersytetu Medycznego w Łodzi. rafal.pawliczak@csk.am.lodz.pl
D001402:B-Lymphocytes / Q000378:metabolism; D017074:Common Variable Immunodeficiency / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D011379:Prognosis; D013601:T-Lymphocytes / Q000378:metabolism
Pospolity zmienny niedobór odporności--postepy w diagnostyce, zrozumienie patogenezy i leczenia.