title: 5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).
abstract: A novel series of pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3).
authors.affiliation: Department of Medicinal Chemistry, Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline Research Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. jason_witherington@gsk.com
authors.forename: Jason
authors.initials: J
authors.lastname: Witherington
authors.forename: Vincent
authors.initials: V
authors.lastname: Bordas
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Garland
authors.forename: Deirdre M B
authors.initials: DM
authors.lastname: Hickey
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Ife
authors.forename: John
authors.initials: J
authors.lastname: Liddle
authors.forename: Martin
authors.initials: M
authors.lastname: Saunders
authors.forename: David G
authors.initials: DG
authors.lastname: Smith
authors.forename: Robert W
authors.initials: RW
authors.lastname: Ward
mesh_terms: D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors* / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D011720:Pyrazoles; D011725:Pyridines; D038362:Glycogen Synthase Kinase 3