title: Pyridine-sugar conjugates as potent inhibitors of enzyme-catalysed glycoside hydrolysis.
abstract: A series of O- and N-linked pseudo-disaccharides incorporating simple functionalised pyridines were synthesized and demonstrated potent inhibition of the glucoamylase-catalysed reaction.
authors.affiliation: School of Chemical Sciences, University of East Anglia, Norwich, UK NR4 7TJ.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Nkansah
authors.forename: Alan H
authors.initials: AH
authors.lastname: Haines
authors.forename: N Patrick J
authors.initials: NP
authors.lastname: Stamford
mesh_terms: D002384:Catalysis; D004187:Disaccharides / Q000737:chemistry* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D005087:Glucan 1,4-alpha-Glucosidase / Q000037:antagonists & inhibitors*; D006868:Hydrolysis; D007700:Kinetics; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D004187:Disaccharides; D004791:Enzyme Inhibitors; D011725:Pyridines; D005087:Glucan 1,4-alpha-Glucosidase