Cytotoxic prenylflavanones from Taiwanese propolis.
Two new prenylflavanones, propolin A (2) and propolin B (3), were isolated and characterized from Taiwanese propolis. Both compounds were found to have cytotoxic properties against three cancer cell lines. DNA content analyses and DNA fragmentation indicated that propolin A (2) efficiently induced apoptosis in cancer cell lines, but had no effect on the cell cycle program. Furthermore, both propolin A (2) and B (3) are potential antioxidant agents and show strong scavenging effects against most types of free radicals.
Chen
Chia-Nan
CN
Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1, Section 1, Jen-ai Road, Taipei, Taiwan 100, Republic of China.
Wu
Chia-Li
CL
Shy
Horng-Shing
HS
Lin
Jen-Kun
JK
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017209:Apoptosis; D001516:Bees / Q000737:chemistry*; D004247:DNA / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005910:Glioma; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D008545:Melanoma; D011429:Propolis / Q000737:chemistry*; D013624:Taiwan; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D000975:Antioxidants; D005419:Flavonoids; D016166:Free Radical Scavengers; C477615:propolin A; C477616:propolin B; D004247:DNA; D011429:Propolis