title: Sphingolipids from Bombycis Corpus 101A and their neurotrophic effects.
abstract: Three new (2-4) and one known (1) sphingolipid were identified in the MeOH extract of Bombycis Corpus 101A. Their structures were elucidated as (4E,2S,3R)-2-N-octadecanoyl-4-tetradecasphingenine (1), (4E,6E,2S,3R)-2-N-eicosanoyl-4,6-tetradecasphingadienine (2), (4E,2S,3R)-2-N-eicosanoyl-4-tetradecasphingenine (3), and (4E,6E,2S,3R)-2-N-docosanoyl-4,6-tetradecasphingadienine (4) on the basis of spectroscopic data. Their neurotrophic effects were evaluated by examining PC12 cell neurite outgrowth.
authors.affiliation: College of Pharmacy, Sung Kyun Kwan University, Suwon 440-746, Republic of Korea.
authors.forename: Hak Cheol
authors.initials: HC
authors.lastname: Kwon
authors.forename: Kang Choon
authors.initials: KC
authors.lastname: Lee
authors.forename: Ock Ryun
authors.initials: OR
authors.lastname: Cho
authors.forename: I Yeon
authors.initials: IY
authors.lastname: Jung
authors.forename: Sae Yun
authors.initials: SY
authors.lastname: Cho
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000818:Animals; D012831:Bombyx / Q000737:chemistry*; D007723:Korea; D007814:Larva / Q000737:chemistry; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells / Q000187:drug effects; D051381:Rats; D013107:Sphingolipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D009414:Nerve Growth Factors; D013107:Sphingolipids