title: HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish.
abstract: Polymorphism of the human leukocyte antigen has been implicated in a number of autoimmune disorders including ageing. In the course of the present study, no association of the human leukocyte antigen (HLA)-A1, B8, DR3 haplotype with a male Irish aged population, as previously reported, was observed. Two polymorphic nucleotides in the TNF cluster (G-308A TNF-alpha and G+252A TNF-beta), associated with increased TNF-alpha production, were shown to be in tight linkage disequilibrium with the class I and II HLA loci, generating HLA haplotypes with extended linkage disequilibrium. However, no age-related allele or genotype frequencies were observed for either polymorphic nucleotide.
authors.affiliation: Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, BT9 7TS, Northern Ireland, Belfast, UK. owenaross@hotmail.com
authors.forename: Owen A
authors.initials: OA
authors.lastname: Ross
authors.forename: Martin D
authors.initials: MD
authors.lastname: Curran
authors.forename: I Maeve
authors.initials: IM
authors.lastname: Rea
authors.forename: Paul
authors.initials: P
authors.lastname: Hyland
authors.forename: Orla
authors.initials: O
authors.lastname: Duggan
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Barnett
authors.forename: Kathryn
authors.initials: K
authors.lastname: Annett
authors.forename: Chris
authors.initials: C
authors.lastname: Patterson
authors.forename: Yvonne A
authors.initials: YA
authors.lastname: Barnett
authors.forename: Derek
authors.initials: D
authors.lastname: Middleton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006650:Histocompatibility Testing; D006801:Humans; D015810:Linkage Disequilibrium; D008136:Longevity / Q000235:genetics* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009660:Northern Ireland; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha