The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease.
Platelet adhesion and aggregation play key roles in initiating coronary thrombosis and acute coronary syndromes. During the last decade platelet glycoprotein Ia and IIIa polymorphisms have been studied intensely in order to clarify their contribution to the thrombotic process and moreover their role in acute coronary syndromes. Studies examining these polymorphisms have been inconclusive and often controversial. Polymorphisms in the glycoprotein Ia seem to increase the risk for acute coronary events in younger persons and especially in the presence of other risk factors. The correlation of the Leu33Pro allele of platelet glycoprotein IIIa regarding platelet thrombogenicity is strong but it does not seem to alter the thrombotic risk of the general population. In conclusion, further studies need to elucidate their impact and the potential association with acute thrombotic events.
Charakida
Marietta
M
Department of Cardiology, Athens University, S. Karagiorga 69, 16675 Athens, Greece.
Tousoulis
Dimitris
D
Stefanadis
Christodoulos
C
Toutouzas
Pavlos
P
D000328:Adult; D017677:Age Distribution; D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics; D003328:Coronary Thrombosis / Q000235:genetics* / Q000401:mortality; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D039421:Integrin alpha2 / Q000235:genetics*; D039661:Integrin beta3 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D012307:Risk Factors; D012680:Sensitivity and Specificity; D017678:Sex Distribution
D005819:Genetic Markers; D039421:Integrin alpha2; D039661:Integrin beta3