title: Two cases of infertile bitches with 78,XX/77,X mosaic karyotype: a need for cytogenetic evaluation of dogs with reproductive disorders.
abstract: A mosaic karyotype 78,XX/77,X was found in two infertile purebred dogs. Cytogenetic investigations were carried out on a large number of metaphase spreads (220 and 473) with the use of conventional Giemsa staining, C-banding, and chromosome painting approaches. The frequencies of the monosomic spreads (77,X) were low: 5.3% and 5.6%. We recommend that at least 90 metaphase spreads be analyzed to allow possible detection of low-level XX/X mosaicism, and we discuss the need for cytogenetic evaluation of dogs with reproductive disorders.
authors.affiliation: Department of Genetics and Animal Breeding, August Cieszkowski Agricultural University of Poznán, Wolynska 33, 60-637 Poznán, Poland. switonsk@jay.au.poznan.pl
authors.forename: M
authors.initials: M
authors.lastname: Switonski
authors.forename: I
authors.initials: I
authors.lastname: Szczerbal
authors.forename: J
authors.initials: J
authors.lastname: Grewling
authors.forename: P
authors.initials: P
authors.lastname: Antosik
authors.forename: W
authors.initials: W
authors.lastname: Nizanski
authors.forename: F
authors.initials: F
authors.lastname: Yang
mesh_terms: D000782:Aneuploidy; D000818:Animals; D004285:Dogs; D005260:Female; D007247:Infertility, Female / Q000235:genetics*; D009030:Mosaicism; D014960:X Chromosome