Paraoxonase and other coronary risk factors in a community-based cohort.
Oxidative damage to circulating lipids and vascular tissues contributes to the initiation and progression of atherosclerosis. High density lipoprotein provides protection from atherosclerosis and the enzyme paraoxonase may contribute to this effect. The aim of the present study was to examine the trends in paraoxonase activity during the course of a community-directed life-style intervention, and relationships of paraoxonase activity to other coronary heart disease risk factors, in a cohort of Australian Aboriginal people.
Cohen
Jacob
J
Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia.
Jenkins
Alicia J
AJ
Karschimkus
Connie
C
Qing
Su
S
Lee
Chee Teik
CT
O'Dea
Kerin
K
Best
James D
JD
Rowley
Kevin G
KG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D043303:Aryldialkylphosphatase; D001315:Australia; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D002338:Carotenoids / Q000097:blood; D015331:Cohort Studies; D048909:Diabetes Complications; D004032:Diet; D004950:Esterases / Q000097:blood*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking
D008075:Lipoproteins, HDL; D002338:Carotenoids; D004950:Esterases; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase