FR252921, a novel immunosuppressive agent isolated from Pseudomonas fluorescens no. 408813 III. In vivo activities.
A novel immunosuppressive agent, FR252921 was isolated from the cultured broth of a species of Pseudomonas fluorescens. We have shown that FR252921 inhibit activating protein-1 (AP-1) transcription activity and act dominantly against antigen presenting cells comparing to T cell. Possibility of FR252921 as concomitant drug of FK506, T-cell specific inhibitor was evaluated. FR252921 showed synergy with FK506 in immunosuppressive activity both in splenic proliferation and in murine skin transplantation.
Fujine
Kiyotaka
K
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. kiyotaka-fujine@po.fujisawa.co.jp
Ueda
Hirotsugu
H
Hino
Motohiro
M
Fujii
Takashi
T
D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000276:immunology; D004357:Drug Synergism; D005260:Female; D006085:Graft Survival / Q000187:drug effects / Q000276:immunology; D007166:Immunosuppressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D007769:Lactams / Q000302:isolation & purification / Q000494:pharmacology*; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D011551:Pseudomonas fluorescens / Q000737:chemistry* / Q000378:metabolism; D016038:Skin Transplantation / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D016559:Tacrolimus / Q000494:pharmacology
C474178:FR 252921; D007166:Immunosuppressive Agents; D007769:Lactams; D007783:Lactones; D009173:Mycophenolic Acid; D016559:Tacrolimus