Trisphaerolide A, a novel polyketide from the Dominican sponge Erylus trisphaerus.
The structure of trisphaerolide A (1), a mildly cytotoxic metabolite isolated from extracts of the marine sponge Erylus trisphaerus collected in Dominica, has been elucidated by detailed analysis of spectroscopic data. Trisphaerolide A (1) has a putative polyketide biogenesis, incorporating a rare variant on the standard pathway, which involves the addition of methyl branches arising from C-2 carbons of acetate units to chain carbons that arise from C-1 of acetate units.
van Altena
Ian
I
Department of Chemistry and Earth & Ocean Sciences, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.
van Soest
Rob
R
Roberge
Michel
M
Andersen
Raymond J
RJ
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001555:Benzene Derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019424:Dominica; D004354:Drug Screening Assays, Antitumor; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D001555:Benzene Derivatives; D007783:Lactones; C477585:trisphaerolide A