title: No association between Glu298Asp endothelial nitric oxide synthase polymorphism and Italian sporadic Alzheimer's disease.
abstract: A great amount of evidence suggests that neuroinflammation may be a major pathogenetic mechanism in the pathophysiology of sporadic Alzheimer's Disease (sAD). Recently, polymorphisms in the endothelial nitric oxide synthase (NOS3) gene have been associated to late onset Alzheimer's Disease in a British population. However, other groups failed to replicate this finding in Asiatic and Caucasian populations. We conducted a case-control study including a clinically well-defined group of 149 sAD patients and 149 age and sex matched controls to test the association between NOS3 Glu298Asp polymorphism and sAD in an ethnically homogenous Italian population. All subjects were genotyped at NOS3 and apolipoprotein E. No significant difference was found in either allele or genotype frequencies between cases and controls, even after stratification for Apolipoprotein E4 carrier status. The NOS3 Glu298Asp polymorphism does not appear to influence the risk of developing sAD in an Italian population.
authors.affiliation: Department of Neurology and Rehabilitation, Centre for Aging Brain and Dementia, Institute of Neuropsychiatry, University of Palermo, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Monastero
authors.forename: Angelo B
authors.initials: AB
authors.lastname: Cefalù
authors.forename: Cecilia
authors.initials: C
authors.lastname: Camarda
authors.forename: Carmela M
authors.initials: CM
authors.lastname: Buglino
authors.forename: Marina
authors.initials: M
authors.lastname: Mannino
authors.forename: Carlo M
authors.initials: CM
authors.lastname: Barbagallo
authors.forename: Gianluca
authors.initials: G
authors.lastname: Lopez
authors.forename: Lawrence K C
authors.initials: LK
authors.lastname: Camarda
authors.forename: Salvatore
authors.initials: S
authors.lastname: Travali
authors.forename: Rosolino
authors.initials: R
authors.lastname: Camarda
authors.forename: Maurizio R
authors.initials: MR
authors.lastname: Averna
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004151:Dipeptides / Q000235:genetics*; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III; D011110:Polymorphism, Genetic / Q000502:physiology*
chemical_list: D004151:Dipeptides; C021030:gamma-glutamylaspartic acid; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III