[Study on the strategy of Japanese encephalitis immunization using live attenuated vaccine combined with inactivated vaccine].
OBJECTIVE
Using the advantages of Japanese encephalitis live attenuated and inactivated vaccine, to reduce the rate of immunization reaction and to increase the effect, we conducted a study on the strategy of immunization in Japanese encephalitis using live attenuated vaccine combined with inactivated vaccine.


METHODS
Observing the safety and immune effects of different groups.


RESULTS
Data on side effect showed that the rate of moderate and severe systematic reactions of the group who were inoculated with combined vaccine was 0.73%, with local reaction 1.46% while the combined rate of moderate and severe systematic reaction of the group who were inoculated with inactivated vaccine was 2.8%. Under the detection of serum neutralizing antibody, the GMT rose from 1:1.05 - 1:3.35 before vaccination to 1:47.34 - 1:101.30 after vaccination in the different groups. Neutralizing antibody was detected in 97.67% of the combined group. There was a significant difference by comparing neutralizing antibody seroconversion rate of the combined group with the inactivated group (chi(2) = 3.89, P < 0.05), but no significant difference with attenuated group (chi(2) = 0.74, P > 0.05).


CONCLUSIONS
Results showed that in children who previously had been immunized with two doses of inactivated vaccine, the booster administration of live attenuated vaccine was both effective and safe.
Ma
Fu-bao
FB
Jiangsu Provincial Center for Disease Prevention and Control, Nanjing 210009, China.
Zheng
Li
L
Bi
Cheng
C
Tao
Hong
H
Zhou
Yong-lin
YL
Zhang
Jin-lin
JL
Tang
Fen-yang
FY
Xie
Ping
P
Zheng
Chun-zao
CZ
Peng
Wei-bin
WB
Jiang
Ren-jie
RJ
D000914:Antibodies, Viral / Q000097:blood; D002675:Child, Preschool; D004664:Encephalitis Virus, Japanese / Q000276:immunology; D006801:Humans; D007114:Immunization; D022321:Japanese Encephalitis Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology
D000914:Antibodies, Viral; D022321:Japanese Encephalitis Vaccines; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated