title: [Research strategy for understanding neuronal plasticity and degeneration].
abstract: After the disclosure of human genomic information in 2003, the new era of post-genomic research will be in full bloom in the field of neuroscience, brain science as well as in neuropsychiatry. In this paper, the authors discussed possible strategies for understanding neuronal plasticity and neuronal degeneration in the post-genomic research paradigm. Five presentations are discussed in the following orders; 1) pharmacogenomics and epigenetics, 2) neuronal stem cell differentiation and transplantation into brain tissue, 3) Elucidation of the mechanism of neuro-protection and neurogenesis, 4) mechanisms of protein processing, especially importance of regulated intramembranous proteolysis, and 5) simulation analysis of signal transduction pathways. All of these newly developing strategies will be of increasing importance in the research in neuropsychiatry.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeda
authors.forename: Masayasu
authors.initials: M
authors.lastname: Okochi
authors.forename: Kiminobu
authors.initials: K
authors.lastname: Sugaya
authors.forename: Chuang
authors.initials: C
authors.lastname: De-Maw
authors.forename: Ryota
authors.initials: R
authors.lastname: Hashimoto
authors.forename: Shinya
authors.initials: S
authors.lastname: Kuroda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shinosaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Kudo
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Tanaka
authors.forename: Ramón
authors.initials: R
authors.lastname: Cacabelos
mesh_terms: D009410:Nerve Degeneration; D009416:Nerve Regeneration / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D010597:Pharmacogenetics; D015398:Signal Transduction / Q000502:physiology