title: [Effectiveness of sporobacterin in the prevention and treatment (of postoperative wound infections)].
abstract: Peculiarities of penetration of living bacterial cultures of Bacillus strain into the structures of the abdominal wall, their positive influence upon the reparative regeneration of surgical wounds were studied in experiments in 240 rats. It was found the living bacterial preparation to be expedient to use as an antagonist of pyogenic infection for purulent postoperative wounds and in order to prevent its development. The clinical antiinflammatory and stimulating the reparative process effects of sporobacterin were studied in 50 patients with infectious wound complications after urgent and scheduled operations. A prophylactic effect was noted in 145 patients operated on for complications of cholelithiasis and commissural ileus. Sporobacterin was proved to give better results of treatment as compared with traditional methods of antiinflammatory therapy with antibiotics.
authors.forename: N I
authors.initials: NI
authors.lastname: Slepykh
authors.forename: A A
authors.initials: AA
authors.lastname: Tret'iakov
authors.forename: A A
authors.initials: AA
authors.lastname: Stadnikov
authors.forename: S V
authors.initials: SV
authors.lastname: Petrov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001407:Bacillus; D002764:Cholecystitis / Q000150:complications / Q000601:surgery; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000150:complications / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019936:Probiotics / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D013492:Suppuration / Q000188:drug therapy / Q000517:prevention & control; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000517:prevention & control*; D013997:Time Factors; D016896:Treatment Outcome
vernacular_title: Otsenka éffektivnosti ispol'zovaniia sporobakterina v profilaktike i lechenii.