title: Analysis of gene expression in the developing mouse retina.
abstract: In the visual system, differential gene expression underlies development of the anterior-posterior and dorsal-ventral axes. Here we present the results of a microarray screen to identify genes differentially expressed in the developing retina. We assayed gene expression in nasal (anterior), temporal (posterior), dorsal, and ventral embryonic mouse retina. We used a statistical method to estimate gene expression between different retina regions. Genes were clustered according to their expression pattern and were ranked within each cluster. We identified groups of genes expressed in gradients or with restricted patterns of expression as verified by in situ hybridization. A common theme for the identified genes is the differential expression in the dorsal-ventral axis. By analyzing gene expression patterns, we provide insight into the molecular organization of the developing retina.
authors.affiliation: Department of Molecular and Cell Biology, Functional Genomics Laboratory, Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.
authors.forename: Elva
authors.initials: E
authors.lastname: Díaz
authors.forename: Yee Hwa
authors.initials: YH
authors.lastname: Yang
authors.forename: Todd
authors.initials: T
authors.lastname: Ferreira
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Loh
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Hayashizaki
authors.forename: Marc
authors.initials: M
authors.lastname: Tessier-Lavigne
authors.forename: Terence P
authors.initials: TP
authors.lastname: Speed
authors.forename: John
authors.initials: J
authors.lastname: Ngai
mesh_terms: D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D020869:Gene Expression Profiling; D051379:Mice; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis; D012160:Retina / Q000201:enzymology / Q000378:metabolism*
chemical_list: D017931:DNA Primers