[Resistance of Escherichia coli to "Intercid", a leukocyte cation protein].
In vitro experiments on 120 E. coli strains isolated from different sources (43 from water, 22 from the feces of healthy persons, 55 from patients with extraintestinal E. coli infections) have demonstrated that some of E. coli isolated, mainly the causative agents of extraintestinal infections, are resistant to the antibacterial action of "intercid" and have anti-Intercid activity (AIA) and a high level of antilysozyme activity. The use of the correlation and two-factor analyses has made it possible to establish the relationship between these characteristics and to find out an even more important contribution of AIA to the determination of bacterial Intercid-resistance (fusion force h2 = 13.1-25.0%). Experiments on E. coli isogenic variants with phenotypes AIA+ and AIA- have shown that AIA is an additional factor which determines the resistance of E. coli to "intercid".
Gritsenko
V A
VA
Research Institute of Cellular and Intracellular Symbiosis, Orenburg, Russia.
Shukhman
M G
MG
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D001437:Bacteriuria / Q000382:microbiology; D001798:Blood Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D002412:Cations; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D006801:Humans; D007962:Leukocytes / Q000737:chemistry; D009113:Muramidase / Q000037:antagonists & inhibitors; D014871:Water Microbiology
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D002412:Cations; D009113:Muramidase
Ustoĭchivost' Esherichia coli k leĭkotsitarnomu kationnomu belku "intertsidu."