title: [Systematic characterization of sonomorphological changes in the early stage of rheumatoid arthritis].
abstract: OBJECTIVE
  The early stage of rheumatoid arthritis (RA) is primarily manifested in the soft tissue of the hand. Although ultrasound (US) is regarded as an important imaging process in diagnostic medicine, precise characterization of sonomorphological changes has not yet been undertaken.
  
  
  METHODS
  20 patients with RA were examined with US. Two radiologists described semiquantitatively the characteristics of synovial changes in the hand in a consensus-based process and measured the synovial width. Statistical methods were used to determine whether the various synovial changes differed significantly and to identify the most frequent locations of changes.
  
  
  RESULTS
  On the basis of the significant differences in morphology and synovial width, it is possible to distinguish between unremarkable findings, pannus tissue and band-like synovitis. Pannus tissue is most frequently found on the finger flexor tendons (FFT), the metacarpophalangeal joints (MCP) and the tendon of M. extensor carpi ulnaris (ECU). Band-like synovitis exhibits an uncharacteristic distribution pattern with a slight propensity to favour these locations.
  
  
  CONCLUSIONS
  The FFT, MCP joints and ECU tendons are particularly important in systematic US screening of the hand for the purpose of establishing reliable evidence of inflammatory changes. Different stages of RA can be identified on the basis of the characteristic types of synovitis and the number of joints and tendons affected.
authors.affiliation: Institut für Klinische Radiologie-Innenstadt, Ludwig-Maximilians-Universität München, Munich. Christoph.Krolak@radin.med.uni-muenchen.de
authors.forename: C
authors.initials: C
authors.lastname: Krolak
authors.forename: S
authors.initials: S
authors.lastname: Wirth
authors.forename: S
authors.initials: S
authors.lastname: Hoepfner
authors.forename: M
authors.initials: M
authors.lastname: Treitl
authors.forename: C
authors.initials: C
authors.lastname: Becker-Gaab
authors.forename: M
authors.initials: M
authors.lastname: Reiser
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D013583:Synovial Membrane / Q000000981:diagnostic imaging / Q000473:pathology; D013585:Synovitis / Q000000981:diagnostic imaging* / Q000473:pathology; D014463:Ultrasonography
vernacular_title: Systematische Charakterisierung der sonomorphologischen Veränderungen in den Frühstadien der rheumatoiden Arthritis.