Diastereoselective synthesis of piperazines by manganese-mediated reductive cyclization.
A simple and effective synthesis of trans aryl-substituted piperazines using a Brønsted acid and manganese(0) is described. [reaction: see text]
Mercer
Gregory J
GJ
Department of Chemistry, University of Utah, 315 S. 1400 East, Salt Lake City, UT 84112-8500, USA.
Sigman
Matthew S
MS
D003500:Cyclization; D019281:Dimerization; D007097:Imines / Q000737:chemistry; D008345:Manganese / Q000737:chemistry*; D010084:Oxidation-Reduction; D010879:Piperazines / Q000138:chemical synthesis*; D013237:Stereoisomerism
D007097:Imines; D010879:Piperazines; D008345:Manganese