title: Novel 3-N-aminoglycoside acetyltransferase gene, aac(3)-Ic, from a Pseudomonas aeruginosa integron.
abstract: A novel gene, aac(3)-Ic, encoding an AAC(3)-I aminoglycoside 3-N-acetyltransferase, was identified on a gene cassette inserted into a Pseudomonas aeruginosa integron that also carries a bla(VIM-2) and a cmlA7 gene cassette. The aac(3)-Ic gene product is 59 and 57% identical to AAC(3)-Ia and AAC(3)-Ib, respectively, and confers resistance to gentamicin and sisomicin.
authors.affiliation: Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, I-53100 Siena, Italy.
authors.forename: Maria Letizia
authors.initials: ML
authors.lastname: Riccio
authors.forename: Jean-Denis
authors.initials: JD
authors.lastname: Docquier
authors.forename: Emanuela
authors.initials: E
authors.lastname: Dell'Amico
authors.forename: Francesco
authors.initials: F
authors.lastname: Luzzaro
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Amicosante
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Rossolini
mesh_terms: D000123:Acetyltransferases / Q000235:genetics*; D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D032023:Integrons; D008969:Molecular Sequence Data; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D000123:Acetyltransferases; C019681:aminoglycoside acetyltransferase; C425108:beta-lactamase bla(vim-2); D001618:beta-Lactamases