title: [Experience on clinical application of positron emission tomography with a new radiopharmaceutical preparation sodium 11C-butyrate in differential diagnosis of pathological volume in brain formation].
abstract: The study was aimed to investigate the possibilities of the application of a new radiopharmaceutical--"Sodium butyrate, [1-(11)C]" (11C-Butyrate) for differential diagnosis of pathological volume brain formations. Positron emission tomography (PET) ("Ecat Exact 47", Siemens) of the brain was performed in 24 patients (14 male & 10 female, aged 19-56). The scanning was carried out as static scan 4-5 min after intravenous administration of 250-350 Mbq 11C-Butyrate and proceeded within 15-20 min. In addition PET with 18F-FDG was performed in all patients. The data had been verified histologically and morphologically. In 15 out of 24 patients the brain malignant tumor has been discovered, in 4 patients--benign tumors, in 5--postoperative cysts. Results of the studies showed that the ratio tumor/normal tissue in case of 11C-Butyrate and 18F-FDG application proved to be comparable for all studied hystological types of tumors. Malignant tumors in these cases had been visualized as a hot sports-fokci of increased uptake 11C-Butyrate (ratio > 1). The obtained data testify to the possibility of 11C-Butyrate application for differential diagnosis of the pathological volumic brain formation.
authors.affiliation: Central Research Institute of Roentgenology and Radiology, Saint-Petersburg.
authors.forename: N A
authors.initials: NA
authors.lastname: Kostenikov
authors.forename: N P
authors.initials: NP
authors.lastname: Fadeev
authors.forename: L A
authors.initials: LA
authors.lastname: Tiutin
authors.forename: V E
authors.initials: VE
authors.lastname: Savello
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Savicheva
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D001932:Brain Neoplasms / Q000175:diagnosis*; D002087:Butyrates; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed
chemical_list: D002087:Butyrates; D019275:Radiopharmaceuticals
vernacular_title: Opyt klinicheskogo primeneniia pozitronnoĭ émissionnoĭ tomografii s novym radiofarmatsevticheskim preparatov 11C-butiratom natriia v differentsial'noĭ diagnostike ob"emnykh obrazovaniĭ golovnogo mozga.