title: [Alexander Project--5 years in Poland].
abstract: The aim of the Alexander Project is to monitor resistance and its trends among the most common bacterial pathogens responsible for community-acquired lower respiratory tract infections and to compare the results obtained between different countries. In Poland, from 1996 to 2000 the percentage of Streptococcus pneumoniae isolates non-susceptible to penicillin was 14.1%. Most often decreased susceptibility to penicillin co-existed with resistance to other classes of antibiotics (multi-drug resistance). The biggest number of pneumococci were resistant to co-trimoxazole (35.2%) and doxycycline (33.6%). Of Haemophilus influenzae isolates, 5.3% produced beta-lactamases. All H. influenzae isolates were susceptible to amoxicillin/clavulanic acid and 3rd-generation cephalosporins. Many isolates of this species were resistant to co-trimoxazole (19.1%). The results of the Alexander Project provide crucial data for guiding national recommendations for empirical treatment of respiratory tract infections.
authors.forename: Waleria
authors.initials: W
authors.lastname: Hryniewicz
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D024841:Fluoroquinolones; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D007769:Lactams; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*; D011044:Poland / Q000453:epidemiology; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D007769:Lactams; D018942:Macrolides
vernacular_title: Projekt Alexander--5 lat w Polsce.