Serum lipids of pemphigus foliaceus patients on long-term glucocorticoid therapy.
Endemic pemphigus foliaceus, and long-term corticotherapy may affect serum lipid levels. The aim of this study was to compare serum lipids of pemphigus foliaceus patients on glucocorticoid therapy to a healthy control group. Fifteen patients receiving prednisone (0.33 +/- 0.22 mg/kg) for at least 12 months and 15 controls were submitted to 48-h food intake records, anthropometry, and biochemical measurements. Data were compared by chi2, Mann-Whitney and Student "t" tests. The groups were matched for gender, age, weight, body mass index, arm circumference and triceps skin fold. No differences were observed in relation to energy, fat, protein and carbohydrate daily intakes, total cholesterol, HDL, LDL, uric acid, and serum creatinine levels. Pemphigus foliaceus patients had higher triglyceride [159 (64-371) vs. 100 (45-133) mg/dl], VLDL [32 (13-74) vs. 20 (9-114) mg/dl] and ESR [44 (9-87) vs. 7 (1-30) mm/h] levels than controls, probably due to metabolic effects of inflammatory disease and corticotherapy.
da Cunha
Selma Freire de Carvalho
SF
Department of Internal Medicine, Faculdade de Medicina do Triângulo Mineiro, Uberaba.
dos Santos
Vitorino Modesto
VM
Monteiro
Jacqueline Pontes
JP
Ferreira
Tácio Pierre Sousa
TP
dos Santos
Jenner Arruda Modesto
JA
dos Santos
Taciana Arruda Modesto
TA
da Cunha
Daniel Ferreira
DF
D001799:Blood Sedimentation / Q000187:drug effects; D016022:Case-Control Studies; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D010392:Pemphigus / Q000097:blood* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D013997:Time Factors
D005938:Glucocorticoids; D008055:Lipids; D011241:Prednisone