Propofol pharmacokinetics in a dwarfism patient.
Pharmacokinetic information is important to control anesthetic depth. However, there are few available pharmacokinetic data of propofol in dwarfism patients. We anesthetized a dwarfism patient who underwent spinal decompression, and investigated the pharmacokinetics of propofol. The patient was a 40-year-old man suffering from muscle weakness and numbness in the arms. The operation consisted of two stages; anterior approach in the supine position and posterior approach in the prone position. We also obtained arterial blood for pharmacokinetic analysis. Distribution volume at steady-state and clearance in the supine position was 180 and 0.92 l min- 1, respectively, and in the prone position 127 and 0.74 l min- 1, respectively, in spite of a continuous infusion of dopamine. The data in the supine position were well predicted by Gepts' parameters (used in Diprifusor Zeneca Ltd, Cheshire, UK), which means the target-controlled infusion (TCI) technique can be available in the supine position, while attention is necessary to avoid overdosing when a patient is placed in the prone position.
Tsubokawa
T
T
Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Faculty of Medicine, Kanazawa University, Kanazawa, Japan. tsune@anesth.m.kanazawa-u.ac.jp
Yamamoto
K
K
Komuro
A
A
Ishizuka
S
S
Kobayashi
T
T
D000328:Adult; D000758:Anesthesia; D018686:Anesthetics, Intravenous / Q000493:pharmacokinetics*; D004392:Dwarfism / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D008297:Male; D016684:Prone Position; D015742:Propofol / Q000493:pharmacokinetics*; D013117:Spinal Cord Compression / Q000601:surgery; D016683:Supine Position
D018686:Anesthetics, Intravenous; D015742:Propofol