Cerebral amyloid angiopathy in aged Chinese: a clinico-neuropathological study.
To investigate the prevalence and clinico-neuropathological characteristics of cerebral amyloid angiopathy (CAA) in aged Chinese and its relationship to dementia and cerebrovascular lesions, we examined 362 archived brains of elderly with immunohistochemical staining for beta-amyloid peptide and Congo red, Bodian and Luxol fast blue stains. We found that: (1) CAA appeared in 31.7% examined brains without sexual preponderance, and the incidence increased with age; (2) the frontal lobe was most frequently involved in CAA, followed by occipital and parietal lobe; (3) subcortical white matter and cerebellum dentate nucleus areas may also be affected by CAA; (4) CAA has a close relationship to Alzheimer's disease and multiple cerebrovascular lesions; (5) CAA alone may result in dementia.
Xu
Dan
D
Department of Geriatric Neurology, Chinese PLA General Hospital, 28 Fuxing Road, 100853 Beijing, P.R. China.
Yang
Chunhui
C
Wang
Luning
L
D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology; D000544:Alzheimer Disease / Q000150:complications / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000378:metabolism / Q000473:pathology; D002681:China / Q000453:epidemiology; D003224:Congo Red / Q000378:metabolism; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism / Q000473:pathology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged
D016229:Amyloid beta-Peptides; D003224:Congo Red