Fluoroquinolone benchmarking in relation to pharmacokinetic and pharmacodynamic parameters.
The expanding class of fluoroquinolone antibiotics comprises numerous agents that differ in pharmacokinetic (PK) characteristics as well as pharmacodynamic (PD) activity. Although generally considered as potent compounds as a class, their individual in vitro activities, as measured by minimum inhibitory concentrations (MIC) demonstrate considerable variability. Objective pharmacological measures such as Cmax/MIC and AUC24/MIC, also known as area under the inhibitory curve (AUIC), have been shown to predict bacteriological eradication, clinical efficacy, emergence of resistant substrains and economic results. These PK/PD measures describe in vivo potency and can provide scientific guidance to clinicians when deciding which agent to use at the bedside of individual patients, and to healthcare administrators when deciding the formulary status for individual agents.
Paladino
Joseph A
JA
CPL Associates LLC, 3980 Sheridan Drive, Amherst, NY 14226, USA. paladino@cplassociates.com
Callen
Wendy A
WA
D000890:Anti-Infective Agents / Q000191:economics / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000627:therapeutic use; D019540:Area Under Curve; D019985:Benchmarking; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones / Q000191:economics / Q000493:pharmacokinetics* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests
D000890:Anti-Infective Agents; D024841:Fluoroquinolones