[Peroxisome proliferator activated receptors and cardiovascular disorders].
Peroxisome proliferator activated receptors (PPARs) are transcription factors only recently discovered. Nevertheless, the interest surrounding their study has involved and involves a continuously growing number of researchers. This is due to the role that PPARs play in the understanding of the pathophysiology of clinical conditions such as obesity, diabetes, atherosclerosis, and angiogenesis. Lipid and glucidic metabolism, synthesis of cytokines, adhesion molecules, coagulation factors, fibrinolysis, are only few of the several processes controlled by PPARs. In this review the more recent acquisitions on PPAR mechanisms of action will be described. The clinical implications that their activation/deactivation induce will be also evaluate. Particular emphasis will be placed on their role in the control of the physiology of lipid and glucidic metabolism, as well as in the pathophysiology of inflammatory and atherosclerotic processes.
Norata
Giuseppe Danilo
GD
Laboratorio del Metabolismo Lipoproteico, Centro per lo Studio dell'Aterosclerosi, Dipartimento di Scienze Farmacologiche, Università degli Studi, Via Balzaretti, 9 20133 Milano.
Pellegatta
Fabio
F
Catapano
Alberico Luigi
AL
D001629:Bezafibrate / Q000008:administration & dosage; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D050356:Lipid Metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists* / Q000378:metabolism*; D014157:Transcription Factors / Q000819:agonists* / Q000378:metabolism*; D016896:Treatment Outcome; D014280:Triglycerides / Q000378:metabolism
D000960:Hypolipidemic Agents; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D014280:Triglycerides; D001629:Bezafibrate
"Peroxisome proliferator activated receptors" e patologie cardiovascolari.