Fluorous solvent as a new phase-screen medium between reagents and reactants in the bromination and chlorination of alcohols.
[reaction: see text] A perfluorohexane layer regulates the rate of reagent transport in the bromination and chlorination of alcohols. A fluorous triphasic U-tube method is effective for lighter reagents; the thionyl chloride layer (yellow) vanishes, and the chlorides are obtained from the right top organic layer in the chlorination of alcohols.
Nakamura
Hiroyuki
H
Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171-8588, Japan. hiroyuki.nakamura@gakushuin.ac.jp
Usui
Taikou
T
Kuroda
Hirokazu
H
Ryu
Ilhyong
I
Matsubara
Hiroshi
H
Yasuda
Shinji
S
Curran
Dennis P
DP