title: Erythematous and reticular forms of oral lichen planus and oral lichenoid reactions differ in pathological features related to disease activity.
abstract: BACKGROUND
  Common clinical forms of oral lichen planus (OLP) and oral lichenoid reactions (OLR) are erythematous (ERY) or reticular (RET). The purpose of this study was to find histopathological changes that differ between these forms.
  
  
  METHODS
  Epithelial thickness, epithelial proliferation rate, apoptosis, and HLA-DR expression were compared among 10 reticular and 12 erythematous lesions, and 11 normal oral mucosa samples (NOM).
  
  
  RESULTS
  The epithelium in ERY was thinner than in NOM, whereas RET showed values between ERY and NOM. Cell proliferation increased significantly in ERY as compared with RET and NOM, with no difference between RET and NOM. Relative numbers of epithelial cell nuclei displaying visible chromatin condensation were reduced in ERY form.
  
  
  CONCLUSIONS
  The markedly increased cell proliferation in ERY supports the notion that this form displays a higher disease activity as compared to RET. It can therefore be important to study each disease form separately.
authors.affiliation: Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway. akaratsa@odont.uio.no
authors.forename: Andreas
authors.initials: A
authors.lastname: Karatsaidis
authors.forename: Olav
authors.initials: O
authors.lastname: Schreurs
authors.forename: Kristen
authors.initials: K
authors.lastname: Helgeland
authors.forename: Tony
authors.initials: T
authors.lastname: Axéll
authors.forename: Karl
authors.initials: K
authors.lastname: Schenck
mesh_terms: D001706:Biopsy; D004277:DNA, Single-Stranded / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology*; D004848:Epithelium / Q000378:metabolism / Q000473:pathology*; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D017676:Lichen Planus, Oral / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology
chemical_list: D004277:DNA, Single-Stranded; D006684:HLA-DR Antigens; D019394:Ki-67 Antigen