title: Antileishmanial activity of two gamma-pyrones from Podolepsis hieracioides (Asteraceae).
abstract: Two gamma-pyrones isolated from the seeds of Podolepsis hieracioides (Asteraceae) have been tested for their in vitro leishmanicidal activity against the promastigote form of Leishmania donovani, L. major, L. infantum and L. enriettii (IC(50)=3.76-5.43 microg/ml), and against the amastigote form of L. donovani residing within RAW 264.7 macrophage-like host cells (IC(50)=8.29-8.59 microg/ml). General toxicity of the gamma-pyrones was investigated in parallel against three mammalian cell lines (RAW 264.7, SKMel, and KB; IC(50)=11.5->25.0 microg/ml). Both compounds were not active against Trypanosoma cruzi or Trypanosoma br. brucei (IC(50)>30 microg/ml).
authors.affiliation: Institute of Pharmacy-Pharmaceutical Technology, Biopharmacy and Biotechnology, Freie Universität Berlin, Kelchstrasse 31, D-112169 Berlin, Germany. kayser@zedat.fu-berlin.de
authors.forename: Oliver
authors.initials: O
authors.lastname: Kayser
authors.forename: Albrecht F
authors.initials: AF
authors.lastname: Kiderlen
authors.forename: Simon L
authors.initials: SL
authors.lastname: Croft
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D007891:Leishmania / Q000187:drug effects* / Q000254:growth & development; D010936:Plant Extracts / Q000494:pharmacology; D011753:Pyrones / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D010936:Plant Extracts; D011753:Pyrones