title: Ab initio protein phasing at 1.4 A resolution.
abstract: All the techniques today available for the ab initio crystal structure solution of proteins require that the atomicity condition is satisfied. Accordingly, diffraction data at resolution equal or better than 1.2 A are necessary. This condition reduces the role of the ab initio techniques in macromolecular crystallography. The computer program SIR2002 has been modified in such a way that it may succeed also with 1.4 A resolution diffraction data. The modifications concern all the modules of the program: the modified program also benefits by the efficiency of a figure of merit.
authors.affiliation: Dipartimento di Scienze della Terra, Piazza Università, 06100 Perugia, Italy.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Burla
authors.forename: Benedetta
authors.initials: B
authors.lastname: Carrozzini
authors.forename: Giovanni L
authors.initials: GL
authors.lastname: Cascarano
authors.forename: Liberato
authors.initials: L
authors.lastname: De Caro
authors.forename: Carmelo
authors.initials: C
authors.lastname: Giacovazzo
authors.forename: Giampiero
authors.initials: G
authors.lastname: Polidori
mesh_terms: D003094:Collagen / Q000737:chemistry; D003461:Crystallography / Q000379:methods; D007768:Lactalbumin / Q000737:chemistry; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry*; D012680:Sensitivity and Specificity; D012984:Software
chemical_list: D011506:Proteins; D003094:Collagen; D007768:Lactalbumin