title: [Aldosterone binding by compensatory hypertrophic kidney with disturbed neurotrophic supply in rats].
abstract: We studied certain aspects of interaction between (3H)aldosterone and the cytoplasmic as well as nuclear receptors of renal cells in the rats during compensatory renal hypertrophy at the background of reflex renal dystrophy. The dystrophy developing in the kidney after cutting the sciatic nerve blocks the compensatory increase in specific accumulation of (3H)aldosterone in the cytoplasm of the renal tubular cells. (3H)Aldosterone transport from the cytoplasmic receptors to the nuclear receptors during rat reflex dystrophy of compensatory hypertrophied kidney is lower as compared to the control. The reflex dystrophy induced by a sciatic nerve injury proved to have no effect on the degree of hypertrophy of the only kidney.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, ul. Butlerova 5a, Moscow, 117485 Russia.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Akimov
authors.forename: N S
authors.initials: NS
authors.lastname: Kositsyn
mesh_terms: D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D006984:Hypertrophy / Q000378:metabolism*; D007668:Kidney / Q000294:innervation / Q000473:pathology* / Q000503:physiopathology*; D007684:Kidney Tubules / Q000378:metabolism / Q000473:pathology; D008297:Male; D009392:Nephrectomy / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D012018:Reflex; D012584:Sciatic Nerve / Q000293:injuries
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; D000450:Aldosterone
vernacular_title: Sviazyvanie al'dosterona kompensatorno gipertrofirovannoĭ pochkoĭ krys pri narushenii ee nervnotroficheskogo obespecheniia.