5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).
A novel series of pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3).
Witherington
Jason
J
Department of Medicinal Chemistry, Neurology Centre of Excellence for Drug Discovery, GlaxoSmithKline Research Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. jason_witherington@gsk.com
Bordas
Vincent
V
Garland
Stephen L
SL
Hickey
Deirdre M B
DM
Ife
Robert J
RJ
Liddle
John
J
Saunders
Martin
M
Smith
David G
DG
Ward
Robert W
RW
D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors* / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
D011720:Pyrazoles; D011725:Pyridines; D038362:Glycogen Synthase Kinase 3