Novel antifungal diketopiperazine from marine fungus.
Marine fungi producing antifungal compounds were screened against Pyricularia oryzae (P. oryzae), and a metabolite of marine fungus M-3 isolated from laver (Porphyra yezoensis) showed potent activity. Novel diketopiperazine (1) was isolated from the culture extracts, and its structure was elucidated by spectroscopic methods. The MIC of 1 against P. oryzae was 0.36 microM.
Byun
Hee-Guk
HG
Marine Biotechnology Institute Co. Ltd., Shimizu, Shizuoka 424-0037, Japan bhg@netian.com
Zhang
Huiping
H
Mochizuki
Masami
M
Adachi
Kyoko
K
Shizuri
Yoshikazu
Y
Lee
Won-Jae
WJ
Kim
Se-Kwon
SK
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D005285:Fermentation; D007659:Ketones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D008970:Molecular Weight; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D012275:Oryza / Q000187:drug effects; D010879:Piperazines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000935:Antifungal Agents; D007659:Ketones; D010879:Piperazines