V gamma 9V delta 2 T-cell anergy and complementarity-determining region 3-specific depletion during paroxysm of nonendemic malaria infection.
V gamma 9V delta 2 T lymphocytes strongly respond to phosphoantigens from Plasmodium parasites. Thus, we analyzed the changes in V gamma 9V delta 2 T-cell function and repertoire during the paroxysm phase of nonendemic malaria infection. During malaria paroxysm, V gamma 9V delta 2 T cells were early activated but rapidly became anergic and finally loose J gamma 1.2 V gamma 9 complementarity-determining region 3 transcripts.
Martini
Federico
F
Laboratory of Clinical Pathology, National Institute for Infectious Diseases Lazzaro Spallanzani I.R.C.C.S., Rome, Italy. martini@inmi.it
Paglia
Maria Grazia
MG
Montesano
Carla
C
Enders
Patrick J
PJ
Gentile
Marco
M
Pauza
C David
CD
Gioia
Cristiana
C
Colizzi
Vittorio
V
Narciso
Pasquale
P
Pucillo
Leopoldo Paolo
LP
Poccia
Fabrizio
F
D000328:Adult; D022801:Complementarity Determining Regions / Q000235:genetics*; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007108:Immune Tolerance; D016778:Malaria, Falciparum / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics / Q000502:physiology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D022801:Complementarity Determining Regions; D006684:HLA-DR Antigens; D016692:Receptors, Antigen, T-Cell, gamma-delta