title: Pulmonary lymphangioleiomyomatosis: a case report with immunohistochemical details and DNA analysis.
abstract: A 47-year-old woman is presented with pulmonary lymphangioleiomyomatosis (PLAM) involving the bilateral lung and slight pulmonary function abnormality. Computed tomography scan showed bilateral microcyst formation in the lung. Histologically, proliferating spindle shaped cells with centrilobular emphysema were main findings. Immunohistochemically, these proliferating spindle shaped cells were positive for alpha-smooth muscle actin, desmin, vimentin, HMB45, estrogen receptor and progesterone receptor, but negative for S-100, cytokeratin. Single strand conformation polymorphism (SSCP) and DNA analysis for tuberous sclerosis 1 and 2 showed no significant abnormality.
authors.affiliation: The First Department of Pathology, Iwate Medical University School of Medicine, Morioka 020-8505, Japan.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Pan
authors.forename: Harumasa
authors.initials: H
authors.lastname: Ito
authors.forename: Akira
authors.initials: A
authors.lastname: Kurose
authors.forename: Kohei
authors.initials: K
authors.lastname: Yamauchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inoue
authors.forename: Takashi
authors.initials: T
authors.lastname: Sawai
mesh_terms: D000199:Actins / Q000096:biosynthesis; D000951:Antigens, Neoplasm; D002455:Cell Division; D004247:DNA / Q000235:genetics* / Q000378:metabolism; D003893:Desmin / Q000096:biosynthesis; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007150:Immunohistochemistry; D008168:Lung / Q000473:pathology / Q000502:physiology; D018192:Lymphangioleiomyomatosis / Q000175:diagnosis* / Q000235:genetics*; D058950:Melanoma-Specific Antigens; D008875:Middle Aged; D009130:Muscle, Smooth / Q000378:metabolism; D009363:Neoplasm Proteins / Q000096:biosynthesis; D018807:Polymorphism, Single-Stranded Conformational; D011960:Receptors, Estrogen / Q000096:biosynthesis; D011980:Receptors, Progesterone / Q000096:biosynthesis; D014057:Tomography, X-Ray Computed; D014402:Tuberous Sclerosis / Q000378:metabolism; D014746:Vimentin / Q000096:biosynthesis
chemical_list: D000199:Actins; D000951:Antigens, Neoplasm; D003893:Desmin; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D014746:Vimentin; D004247:DNA