title: Effect of genistein, a tyrosine kinase inhibitor, on TAME-esterase induced contractions in rat aorta in vitro.
abstract: Effect of genistein, a protein tyrosine kinase inhibitor, on TAME-esterase induced contractions were studied on rat aorta strips in vitro. Data showed that TAME-esterase induced contractions were concentration dependent and these contractions were significantly inhibited when rat aorta strips were pre-incubated with genistein. The present findings provide evidence for the possible contribution of tyrosine kinases during TAME-esterase induced contractions in aorta.
authors.affiliation: Department of Health and Medical Sciences, Faculty of Science, University of Mauritius, Reduit, Mauritius.
authors.forename: F B H
authors.initials: FB
authors.lastname: Gurib
authors.forename: A H
authors.initials: AH
authors.lastname: Subratty
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D019833:Genistein / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D010447:Peptide Hydrolases / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004791:Enzyme Inhibitors; D019833:Genistein; D011505:Protein-Tyrosine Kinases; D010447:Peptide Hydrolases; C023073:tosylarginine methyl ester hydrolase