Autoantibodies and glomerulonephritis in systemic lupus erythematosus.
Autoantibody diversification to a variety of autoantigens is a hallmark for systemic autoimmunity. SLE represents a prototype. In this article the roots of the important questions probed by the Kunkel laboratory in SLE research are traced. Data from the recent animal work by the laboratory of Shu Man Fu are summarized to emphasize the importance of further exploration of autoantibody specificities in lupus with a special emphasis on nephritis and to suggest a broader perspective regarding lupus autoantibody reactivities in addition to those against nuclear components.
Fu
S M
SM
University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, and Deparnent of Internal Medicine, University of Virginia School of Medicine, Charlottesville 22908, Virginia, USA. sf2e@virginia.edu
Castillo
J D
JD
Deshmukh
U S
US
Lewis
J E
JE
Waters
S T
ST
Gaskin
F
F
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D004195:Disease Models, Animal; D005921:Glomerulonephritis / Q000097:blood / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens