title: Reversible ventricular dysfunction (takotsubo cardiomyopathy) following polymorphic ventricular tachycardia.
abstract: A 67-year-old female with recurrent syncope and no obvious heart disease developed ventricular dysfunction, known as takotsubo cardiomyopathy, following a 90 s episode of polymorphic ventricular tachycardia originating from a ventricular extrasystole with a short coupling interval. Cardiac catheterization performed 30 min after the arrhythmic event revealed angiographically normal coronary arteries, and left ventricular apical akinesis and basal hyperkinesis. An intracoronary injection of acetylcholine revealed no inducible coronary spasm, and an electrophysiological study revealed normal atrioventricular conduction and no inducible ventricular arrhythmia. Thirty hours after the arrhythmic event, electrocardiography revealed deeply inverted T waves in leads V3 to V6, I, and aVL, which continued for more than a week. Although no treatment was given to maintain hemodynamic stability, echocardiography revealed normal left ventricular contraction 14 days after the onset of the ventricular dysfunction. The reversible ventricular dysfunction might have been induced by altered catecholamine dynamics due to the persistent syncope during the occurrence of tachycardia.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Japan. johnny@marianna-u.ac.jp
authors.forename: Yoshihiro J
authors.initials: YJ
authors.lastname: Akashi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Nakazawa
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kida
authors.forename: Shonosuke
authors.initials: S
authors.lastname: Ryu
authors.forename: Akihiko
authors.initials: A
authors.lastname: Takagi
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kishi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kunishima
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Sakakibara
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Miyake
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005260:Female; D006801:Humans; D013575:Syncope / Q000209:etiology; D017180:Tachycardia, Ventricular / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D014463:Ultrasonography