title: Comparative in vitro surveillance of amoxicillin-clavulanic acid and four oral comparators against 21232 clinical isolates from europe.
abstract: The present study was conducted to determine the in vitro activity of amoxicillin-clavulanic acid compared to that of four newer antimicrobial agents (ampicillin, azithromycin, cefuroxime and trimethoprim-sulfamethoxazole). All of the agents were tested against 21232 recent clinical isolates encompassing 37 species submitted from 16 European countries between 1997 and 1999. After 20 years of clinical use, amoxicillin-clavulanic acid continues to retain much of its initial activity against targeted gram-positive organisms, selected gram-negative organisms and major respiratory pathogens.
authors.affiliation: Laboratories International for Microbiology Studies, 2122 Palmer Drive, Schaumburg, IL 60173-3817, USA. dhoban@ihmainc.com
authors.forename: D J
authors.initials: DJ
authors.lastname: Hoban
authors.forename: S K
authors.initials: SK
authors.lastname: Bouchillon
authors.forename: J L
authors.initials: JL
authors.lastname: Johnson
authors.forename: G G
authors.initials: GG
authors.lastname: Zhanel
authors.forename: D L
authors.initials: DL
authors.lastname: Butler
authors.forename: K A
authors.initials: KA
authors.lastname: Saunders
authors.forename: L A
authors.initials: LA
authors.lastname: Miller
authors.forename: J A
authors.initials: JA
authors.lastname: Poupard
mesh_terms: D000284:Administration, Oral; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology*; D000667:Ampicillin / Q000008:administration & dosage / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D017963:Azithromycin / Q000008:administration & dosage / Q000494:pharmacology; D001424:Bacterial Infections / Q000382:microbiology; D002444:Cefuroxime / Q000008:administration & dosage / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D017963:Azithromycin; D002444:Cefuroxime