Epstein-Barr virus and human herpesvirus 8 coinfection and concomitant extranodal nasal-type NK/T cell lymphoma and Castleman disease: case report.
We describe a 36-year-old man uninfected with human immunodeficiency virus who had confirmed concurrent infection with Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8) and their respective lymphoproliferative manifestations, nasal-type NK/T cell lymphoma and Castleman disease. Antibodies to HHV-8 and EBV DNA were found in plasma and peripheral blood mononuclear cells. An EBV-positive nasal-type NK/T cell lymphoma infiltrated the splenic red pulp, whereas the white pulp contained HHV-8-positive plasmablasts, as found in Castleman disease.
Larroche
Claire
C
Department of Internal Medicine and Infectious Disease, Hôpital Avicenne, Université Paris-Nord, 93009 Bobigny Cedex, France. claire.larroche@avc.ap-hop-paris.fr
Agbalika
Félix
F
Poirel
Hélène
H
Martin
Antoine
A
Gautheret-Dejean
Agnès
A
Raphaël
Martine
M
Lortholary
Olivier
O
D000328:Adult; D015703:Antigens, CD / Q000096:biosynthesis; D005871:Castleman Disease / Q000150:complications* / Q000276:immunology / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000276:immunology; D004854:Herpesvirus 4, Human; D019288:Herpesvirus 8, Human; D006801:Humans; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000276:immunology / Q000821:virology; D008297:Male; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000276:immunology
D015703:Antigens, CD