Humoral immune response and assessment of vaccine virus shedding in calves receiving modified live virus vaccines containing bovine herpesvirus-1 and bovine viral diarrhoea virus 1a.
Susceptible calves were administered modified live virus (MLV) vaccines containing bovine herpesvirus-1 (BHV1) and bovine viral diarrhoea type 1 (BVDV1a) strains intramuscularly, with one vaccine containing both MLV and inactivated BHV-1 and inactivated BVDV1a. There was no evidence of transmission of vaccine (BHV-1 and BVDV1a) strains to susceptible non-vaccinated controls commingled with vaccinates. No vaccinates had detectable BHV-1 in peripheral blood leucocytes (PBL) after vaccination. Each of three vaccines containing an MLV BVDV1a strain caused a transient BVDV vaccine induced viremia in PBL after vaccination, which was cleared as the calves developed serum BVDV1 antibodies. The vaccine containing both MLV and inactivated BHV-1 induced serum BHV-1 antibodies more rapid than MLV BHV-1 vaccine. Two doses of MLV BHV-1 (days 0 and 28) in some cases induced serum BHV-1 antibodies to higher levels and greater duration than one dose.
Fulton
R W
RW
Department of Veterinary Pathobiology, Oklahoma State University, Stillwater, OK 74078, USA. rfulton@okstate.edu
Saliki
J T
JT
Burge
L J
LJ
Payton
M E
ME
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000517:prevention & control* / Q000635:transmission; D002417:Cattle; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology*; D018562:Disease Transmission, Infectious / Q000662:veterinary; D005260:Female; D007242:Herpesvirus 1, Bovine / Q000276:immunology*; D007115:Immunization Schedule; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D009500:Neutralization Tests; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*; D017201:Virus Shedding
D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D017778:Vaccines, Combined; D014765:Viral Vaccines