title: Radial bone mineral density in hemodialysis patients with adynamic bone disease.
abstract: Adynamic bone disease (ABD) has attracted attention as the most frequent type of renal osteodystrophy, but there are few reports about the bone mineral density (BMD) in ABD patients. This study investigated the BMD in hemodialysis patients with ABD and with relatively normal bone turnover. We measured the BMD of the distal one-third of the radius by dual-energy X-ray adsorptiometry. In the ABD group (intact PTH<65 pg/ml, intact osteocalcin<30 ng/ml), there were 19 men and 17 women with a mean age of 56.4 +/- 12.0 years. In the relatively normal bone turnover group (intact PTH: 120-250 pg/ml), there were 24 men and 16 women with a mean age of 57.1 +/- 14.7 years. Although there were no significant differences between the two groups with respect to age, gender, and duration of hemodialysis, a significant increase of the BMD and the calcium x phosphate product was observed in the ABD group (radial BMD: 0.648 +/- 0.137 g/cm2 versus 0.572 +/- 0.132 g/cm2, calcium x phosphate product: 57.53 +/- 14.92 mg2/dl2 versus 49.76 +/- 12.13 mg2/dl2). These findings suggest that an increase in radial BMD may not be a useful marker of the improvement in bone lesions in ABD patients.
authors.affiliation: Department of Internal Medicine, Harada Hospital, Hiroshima, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Nakashima
authors.forename: N
authors.initials: N
authors.lastname: Yorioka
authors.forename: S
authors.initials: S
authors.lastname: Doi
authors.forename: C
authors.initials: C
authors.lastname: Ueda
authors.forename: K
authors.initials: K
authors.lastname: Usui
authors.forename: K
authors.initials: K
authors.lastname: Shigemoto
authors.forename: S
authors.initials: S
authors.lastname: Harada
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015519:Bone Density; D016723:Bone Remodeling / Q000502:physiology*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011884:Radius; D006435:Renal Dialysis