Regioselective N-substitution of cyclen with two different alkyl groups: synthesis of all possible isomers.
All possible configurations of two different groups on the four nitrogen atoms of cyclen were achieved using four differently protected cyclen intermediates including the novel mono-protected cyclen compound, mono-N-Cbz-cyclen.
Yoo
Jeongsoo
J
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO 63110, USA.
Reichert
David E
DE
Welch
Michael J
MJ