Expression of TAK1, a mediator of TGF-beta and BMP signaling, during mouse embryonic development.
TGF-beta activated kinase 1 (TAK1) is a MAP kinase kinase kinase (MAPKKK) that has been shown to function downstream of BMPs and TGF-beta (J. Biol. Chem. 275 (2000) 17647; EMBO J. 17 (1998) 1019; Science 270 (1995) 2008), as well as in the interleukin-1 (IL-1) signaling pathway (J. Biol. Chem. 276 (2001) 3508; Nature 398 (1999) 252). Using immunohistochemistry (IHC), we demonstrate that TAK1 is expressed ubiquitously during early development. At mid-gestation, TAK1 expression becomes more restricted, with high levels seen specifically during development of diverse organs and tissues including the nervous system, testis, kidney, liver and gut. Additionally, TAK1 expression is seen in the developing lung and pancreas. Our results suggest that TAK1 may play multiple roles in mouse development.
Jadrich
Joy L
JL
Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.
O'Connor
Michael B
MB
Coucouvanis
Electra
E
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000378:metabolism*; D020869:Gene Expression Profiling; D020930:MAP Kinase Kinase Kinases / Q000235:genetics* / Q000378:metabolism; D008297:Male; D051379:Mice; D009420:Nervous System / Q000196:embryology; D013737:Testis / Q000196:embryology; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D000099151:MAP Kinase Kinase Kinase 7
D019485:Bone Morphogenetic Proteins; D020930:MAP Kinase Kinase Kinases; D016212:Transforming Growth Factor beta; D000099151:MAP Kinase Kinase Kinase 7