title: Linear scleroderma "en coup de sabre" coexisting with plaque-morphea: neuroradiological manifestation and response to corticosteroids.
abstract: A 24 year old woman in the 33rd week of pregnancy developed progressive neurological complications with right sided hemiparesis in association with the occurrence of linear scleroderma "en coup de sabre" (LSCS) and pre-existing plaque-morphea, already being treated by balneophototherapy. Further progression of neurological symptoms led to a caesarean section with the delivery of a healthy child. Brain magnetic resonance imaging (MRI) showed focal T2 signal increases in the left frontoparietal region directly adjacent to the area of LSCS. Cerebrospinal fluid analysis revealed oligoclonal bands, suggesting an intracerebral inflammatory process. Subsequent pulsed corticosteroid treatment led to a remission of neurological symptoms and to a marked resolution of the MRI lesions.
authors.affiliation: Universitätsklinik für Neurologie, Innsbruck, Austria. iris.unterberger@uibk.ac.at
authors.forename: I
authors.initials: I
authors.lastname: Unterberger
authors.forename: E
authors.initials: E
authors.lastname: Trinka
authors.forename: K
authors.initials: K
authors.lastname: Engelhardt
authors.forename: A
authors.initials: A
authors.lastname: Muigg
authors.forename: P
authors.initials: P
authors.lastname: Eller
authors.forename: M
authors.initials: M
authors.lastname: Wagner
authors.forename: N
authors.initials: N
authors.lastname: Sepp
authors.forename: G
authors.initials: G
authors.lastname: Bauer
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000188:drug therapy*; D020551:Pulse Therapy, Drug; D012594:Scleroderma, Localized / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D018696:Neuroprotective Agents; D008775:Methylprednisolone