title: Sialoglycoprotein and carbohydrate complexes in chromium toxicity.
abstract: Chromium(VI) compounds are amongst the most widely encountered industrial carcinogens and are of increasing concern with respect to environmental exposure. Sialoglycoproteins and carbohydrates play a crucial role in stabilizing oxoCr(V) intermediates, which are produced by extracellular and intracellular reduction of chromium(VI). Recent research has addressed the molecular characterization of oxoCr(V)-sialoglycoprotein and -carbohydrate complexes and the roles that these species may play in Cr(VI) metabolism and carcinogenesis. Particular highlights include the role of oxoCr(V) complexes of extracellular sialoglycoproteins, intracellular D-glucose, and related species and their potential roles in Cr(VI)-induced genotoxicity.
authors.affiliation: Centre for Heavy Metals Research, School of Chemistry, University of Sydney, NSW 2006, Australia.
authors.forename: Rachel
authors.initials: R
authors.lastname: Codd
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Irwin
authors.forename: Peter A
authors.initials: PA
authors.lastname: Lay
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity; D002857:Chromium / Q000378:metabolism / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity; D006801:Humans; D009153:Mutagens / Q000633:toxicity; D012795:Sialoglycoproteins / Q000378:metabolism / Q000633:toxicity*
chemical_list: D002241:Carbohydrates; D002273:Carcinogens; D004785:Environmental Pollutants; D009153:Mutagens; D012795:Sialoglycoproteins; D002857:Chromium