Nitrendipine-induced subacute cutaneous lupus erythematosus.
A 66-year-old man presented with widespread annular and bullous subacute cutaneous lupus erythematosus (SCLE), developed after starting treatment for hypertension with the calcium channel blocker nitrendipine. A few days after withdrawal of the drug, while cutaneous manifestations were improving, left hemiparesis occurred. Laboratory investigations showed, in addition to anti-Ro, anti-La and anti-histone antibodies, the presence of lupus anticoagulant, anticardiolipin antibodies, prolonged APTT and thrombocytopenia. On the basis of the spontaneous regression of the patient's skin lesions after discontinuation of the drug, a possible relationship between nitrendipine intake, the clinical events and the biological findings is discussed.
Marzano
Angelo V
AV
Institute of Dermatological Sciences of the University of Milan, Via Pace, Italy. mizzidoc@libero.it
Borghi
Alessandro
A
Mercogliano
Maurizio
M
Facchetti
Maura
M
Caputo
Ruggero
R
D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced* / Q000276:immunology*; D008297:Male; D009568:Nitrendipine / Q000009:adverse effects*; D010291:Paresis / Q000139:chemically induced
D001323:Autoantibodies; D002121:Calcium Channel Blockers; D009568:Nitrendipine