Serum CA-125 tumor marker in endometrial adenocarcinoma.
One hundred and seventy-four patients, mean age 61.23 +/- 9.41 years old, with irregular perimenopausal haemorrhage were included in the study. Fractional curettage was performed in all patients. When the pathohistologic findings were adenocarcinoma the concentration of CA-125 tumor marker was determined. Hysterectomy with bilateral salpingo-oophorectomy was determined. In 142 cases carcinoma was restricted to the uterus and in 32 patients extrauterine metastatic disease was found. In the former group CA-125 was positive in 130 patients with a mean value of 64.12 +/- 22.41 U/ml serum. In the latter group the cancer antigen was positive in 29 patients with a mean value of 244.82 +/- 68.11 U/ml. High production is associated with increased metastatic potential.
Kukura
V
V
Department of Gynecology and Obstetrics, Merkur University Hospital, Zagreb, Croatia.
Zovko
G
G
Ciglar
S
S
Markulin-Grgić
L
L
Santek
F
F
Podgajski
M
M
Duić
Z
Z
D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology; D000368:Aged; D018394:CA-125 Antigen / Q000097:blood*; D016889:Endometrial Neoplasms / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008875:Middle Aged; D012680:Sensitivity and Specificity
D018394:CA-125 Antigen