title: Modification of family size in families reporting history of haemophilia from Maharashtra, India.
abstract: BACKGROUND
  In India, genetic counselling services are largely unavailable. The question of whether awareness of the hereditary nature of the disorder leads to modified family size in affected families remains unanswered. The objective of this study was to determine whether family history of haemophilia resulted in modification of family size in families reporting haemophilia in the State of Maharashtra, India.
  
  
  METHODS
  The study was a retrospective cohort analysis from pedigrees collected from an earlier survey on haemophilia in Maharashtra. Pedigree data were manually defined into families with or without experience of haemophilia. Family size was defined as the number of live births per woman as documented in the pedigree. The data were analysed using Microsoft Excel package (version 2000) and SPSS package (version 10).
  
  
  RESULTS
  Family size of obligate carriers who were daughters of patients was significantly less than the family size of obligate carriers who reported haemophilia in a brother or maternal relative (z = 7.14, P < 0.001). As compared with parents from an older generation, a significant reduction in the number of children born to younger families with haemophilia was observed, irrespective of family history of the condition. In families with history of haemophilia, there was no significant reduction in the number of families with more than one affected son in between two generations of parents (chi(2) = 1.43).
  
  
  CONCLUSIONS
  The results revealed a reduction in size of families with haemophilia over a generation, which possibly reflected the reducing fertility trends observed in the Indian population. Reduction in the number of children born to women with a haemophilic father suggested a comprehension of father to daughter transmission of haemophilia. This was not true when relatives other than the father were affected. The lack of significant reduction in the number of families with history of haemophilia of having more than one affected son may suggest a compensatory response to the high mortality associated with the disorder in India.
authors.affiliation: Genetics Laboratory, School of Health Sciences, University of Pune, Pune 411 007, India.
authors.forename: Mugdha
authors.initials: M
authors.lastname: Potnis-Lele
authors.forename: Anita
authors.initials: A
authors.lastname: Kar
mesh_terms: D015331:Cohort Studies; D003657:Decision Making; D005191:Family Characteristics; D005260:Female; D005817:Genetic Counseling; D006467:Hemophilia A / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007194:India; D008297:Male; D010375:Pedigree; D017584:Reproductive History; D012189:Retrospective Studies