title: Additive wake-promoting actions of medial basal forebrain noradrenergic alpha1- and beta-receptor stimulation.
abstract: The locus coeruleus-noradrenergic system exerts an activating influence on forebrain neuronal and behavioral activity states, in part through the actions of noradrenergic beta-receptors in the medial septal (MS) and medial preoptic (MPOA) areas. MPOA alpha1-receptors exert similar wake-promoting actions. The current study examines the influence of alpha1-receptors located within MS on sleep-wake state. In addition, the extent to which alpha1- and beta-receptors located within MS and MPOA interact in the modulation of behavioral state was investigated by examining the effects of individual or combined infusion of alpha1- and beta-agonists into these regions. Results show that alpha1-receptors located within MS exert wake-promoting actions. Within both MS and MPOA, additive wake-promoting actions were observed with alpha1- and beta-receptor stimulation, the sum of which contributes to the overall arousal state of the animal.
authors.affiliation: Department of Psychology, University of Wisconsin-Madison, 53706, USA. berridge@wisc.edu
authors.forename: C W
authors.initials: CW
authors.lastname: Berridge
authors.forename: S O
authors.initials: SO
authors.lastname: Isaac
authors.forename: R A
authors.initials: RA
authors.lastname: España
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000379:methods; D004576:Electromyography / Q000379:methods; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008474:Medial Forebrain Bundle / Q000187:drug effects / Q000502:physiology*; D010656:Phenylephrine / Q000494:pharmacology; D011301:Preoptic Area / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012686:Septal Nuclei / Q000187:drug effects / Q000502:physiology; D012895:Sleep, REM / Q000187:drug effects; D014851:Wakefulness / Q000502:physiology*
chemical_list: D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D018340:Receptors, Adrenergic, alpha-1; D011943:Receptors, Adrenergic, beta; D010656:Phenylephrine; D007545:Isoproterenol