title: Total synthesis of methyl protodioscin: a potent agent with antitumor activity.
abstract: Methyl protodioscin (1), otherwise known as 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-d-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-22-methoxy-25(R)-furost-5-ene-3 beta,26-diol, has been synthesized for the first time from diosgenin through nine steps in an overall yield of 7.8%.
authors.affiliation: School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, P. R. China. zyang@chem.pku.edu.cn
authors.forename: Mao S
authors.initials: MS
authors.lastname: Cheng
authors.forename: Qian L
authors.initials: QL
authors.lastname: Wang
authors.forename: Quan
authors.initials: Q
authors.lastname: Tian
authors.forename: Hong Y
authors.initials: HY
authors.lastname: Song
authors.forename: Yong X
authors.initials: YX
authors.lastname: Liu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Hong D
authors.initials: HD
authors.lastname: Miao
authors.forename: Xin S
authors.initials: XS
authors.lastname: Yao
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques; D004144:Diosgenin / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry; D012503:Saponins / Q000032:analysis / Q000138:chemical synthesis*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; C425324:methyl protodioscin; D004144:Diosgenin