Hypoxic ischemic encephalopathy associated with neonatal seizures without other neurological abnormalities.
We reported three term or near-term infants with parasagittal infarcts. Their Apgar scores were low and the amniotic fluid was meconium-stained. Resuscitation was necessary immediately after birth, but they were not stuporous and no neurological abnormalities were recognized on admission. They showed metabolic acidosis and transient hypoglycemia, and two showed hematoemesis. Seizures were observed between 2 and 15 h of age in all of them. Electroencephalography demonstrated moderate or severe depression, and CT demonstrated bilateral abnormal low densities in the border zones of the middle and posterior cerebral arteries. Two of them had mental retardation and epilepsy, although the other exhibited normal development. Our infants suggest that neonatal seizures can also occur in infants with hypoxic ischemic encephalopathy without apparent neurological abnormalities.
Sato
Yoshiaki
Y
Department of Pediatrics, Anjo Kosei Hospital, Anjo, Japan. yoshiakisato@nifty.com
Okumura
Akihisa
A
Kato
Toru
T
Hayakawa
Fumio
F
Kuno
Kuniyoshi
K
Watanabe
Kazuyoshi
K
D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D004569:Electroencephalography; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications* / Q000503:physiopathology; D007231:Infant, Newborn; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy / Q000209:etiology*; D014057:Tomography, X-Ray Computed
D000927:Anticonvulsants; D010634:Phenobarbital