New evidence of spontaneous cure in human Chagas' disease.
A new case of spontaneous cure of human Chagas' disease is described in Uruguay. An 87-year-old man who had a typical acute phase of Trypanosoma cruzi infection in 1947 and never received specific treatment against the disease, when examined in 1998 revealed several completely negative parasitological and serological tests, including traditional serology, PCR and flow cytometry. As a whole, such findings fulfill the current criteria to define the cure of Chagas' disease. Clinical data suggest the possibility of a benign evolution of Chagas' disease in this case, but the basic findings (slight cardiac and esophageal impairment) could also be due to the advanced age of the patient.
Francolino
Sonia S
SS
National University, Montevideo, Uruguay.
Antunes
Antonio Fernandez
AF
Talice
Rodolfo
R
Rosa
Rachel
R
Selanikio
Joel
J
de Rezende
Joffre Marcondes
JM
Romanha
Alvaro J
AJ
Dias
João Carlos Pinto
JC
D000368:Aged; D000369:Aged, 80 and over; D014355:Chagas Disease / Q000503:physiopathology*; D006801:Humans; D008297:Male; D012075:Remission, Spontaneous