Parvovirus B19 encephalitis presenting as immune restoration disease after highly active antiretroviral therapy for human immunodeficiency virus infection.
Illness occurring during the initial months of highly active antiretroviral therapy (HAART) for human immunodeficiency virus infection may be a consequence of the restoration of an immune response against opportunistic pathogens (i.e., immune restoration disease [IRD]). We describe a young man who had AIDS complicated by parvovirus B19 infection and RBC aplasia and who developed a painless, progressive dyspraxia of the left arm and an expressive dysphasia 4 weeks after commencing effective HAART. Neuroimaging demonstrated multiple right fronto-parietal lesions, and, following extensive investigations, including a brain biopsy, it was concluded that the brain lesions represented IRD associated with parvovirus B19 infection.
Nolan
Richard C
RC
Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, Perth WA-6001, Australia. richard.nolan@health.wa.gov.au
Chidlow
Glenys
G
French
Martyn A
MA
D017088:AIDS-Related Opportunistic Infections / Q000821:virology; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D018792:Encephalitis, Viral / Q000209:etiology*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007109:Immunity; D008297:Male; D010322:Parvoviridae Infections / Q000209:etiology*; D016732:Parvovirus B19, Human; D016133:Polymerase Chain Reaction
D019380:Anti-HIV Agents