title: Efficient entry into medium-ring keto-lactones. The ruthenium tetraoxide-promoted oxidative cleavage of beta-hydroxyethers.
abstract: [reaction: see text] A new use of ruthenium tetraoxide is reported. The catalytic oxidative cleavage of hexahydro-benzofuran-3a-ols led to nine-membered ring keto-lactones in moderate to good yields and high purity. The reaction is clean and easily performed using catalytic amounts of ruthenium trichloride and an excess of sodium periodate as a cooxidant.
authors.affiliation: Instituto de Química, Universidade de São Paulo, CEP 05508-900, São Paulo SP, Brazil. hmferraz@iq.usp.br
authors.forename: Helena M C
authors.initials: HM
authors.lastname: Ferraz
authors.forename: Luiz S
authors.initials: LS
authors.lastname: Longo