title: A novel NO-production-inhibiting triterpene and cytotoxicity of known alkaloids from Euonymus laxiflorus.
abstract: A new triterpene, laxifolone A (1), four known sesquiterpene alkaloids, ebenifoline E-II (2), carigorinine E (3), euojaponine C (4), and emarginatine E (5), and six triterpenoids, 3-hydroxyolean-12-en-22,29-gamma-lactone, 3,11-dioxo-beta-amyrene, 3beta,22alpha-dihydroxyolean-12-en-29-oic acid, 28,29-dihydroxyfriedelan-3-one, 29-hydroxy-3-oxo-D:A-friedooleanan-28-oic acid, and putranjivadione, were isolated from the stems and leaves of Euonymus laxiflorus. Structural elucidations of these compounds were established by spectral analysis. Compound 1 displayed significant nitric oxide (NO) inhibitory effect.
authors.affiliation: National Research Institute of Chinese Medicine, No. 155-1, Li-Nong Street, Section 2, Shih-Pai, Taipei, 112, Taiwan, Republic of China. kuoyh@cma23.nrcm.edu.tw
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Hui-Chi
authors.initials: HC
authors.lastname: Huang
authors.forename: Wen-Fei
authors.initials: WF
authors.lastname: Chiou
authors.forename: Li-Shian
authors.initials: LS
authors.lastname: Shi
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D029756:Euonymus / Q000737:chemistry*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D013624:Taiwan; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D014315:Triterpenes; C477581:laxifolone A; D009569:Nitric Oxide