Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeys.
Mother-reared (MR) and nursery-reared (NR) male rhesus monkeys exhibit profound and persistent differences in social and emotional behavior. Compared to MR animals, NR monkeys show reduced reciprocal social behaviors and increased agonistic behavior and high levels of stereotypy. Cerebrospinal fluid oxytocin (CSF OT) in NR monkeys was significantly reduced compared to MR monkeys measured at 18, 24, and 36 months of age. Correlations between OT and individual social behavioral profiles measured across rearing conditions also revealed a significant association between OT and the expression of affiliative social behaviors including allogrooming and reciprocal intermale mounting at each age examined. In contrast, CSF vasopressin levels did not differ according to rearing history, but did correlate with fearful behaviors independent of rearing history. Differential rearing was not associated with differences in basal or stress-related plasma cortisol, although these levels did progressively decline as monkeys matured. MR but not NR monkeys were able to use a social companion to buffer their response to a stressor, but OT levels did not appear to be sensitive to the presence of a social companion in either group. These results are consistent with earlier reports from studies of rodents suggesting an important role for central OT pathways in the development of social affiliation.
Winslow
James T
JT
Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA. jwinslow@rmy.emory.edu
Noble
Pamela L
PL
Lyons
Casie K
CK
Sterk
Sheila M
SM
Insel
Thomas R
TR
D000818:Animals; D008253:Macaca mulatta; D008297:Male; D008426:Maternal Deprivation; D010121:Oxytocin / Q000134:cerebrospinal fluid*; D012919:Social Behavior; D013312:Stress, Physiological / Q000134:cerebrospinal fluid
D010121:Oxytocin