[Regeneration of tooth and periodontal tissue using tissue engineering concepts].
In the context of minimally invasive surgery, the next logical step is to provide a biological replacement for missing tissue without the need for a harvesting operation. Tissue engineering is defined as the fabrication of living parts for the body from cells in the laboratory. Donor cells such as stem cell or cultivated, differentiated cells are seeded on a appropriately configurated scaffold replicating extracellular matrix. Growth factors are added to the in-vitro system to encourage stem cell proliferation. The engineered structure is then transplanted to the recipient. In this article, the regeneration strategies for tooth and periodontal tissue using tissue engineering concepts. Culture expanded mesenchymal stem cell is useful for periodontal tissue and tooth regeneration with bioabsorbable matrix such as b-TCP and collagen fiber. In the near future, these regenerated tissue will be accepted in clinical situations.
Ueda
Minoru
M
Department of Oraland Maxillofacial Surgery, Nagoya University Postgraduate School of Medicine.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D006133:Growth Substances; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D009061:Mouth Mucosa / Q000502:physiology; D010519:Periodontium / Q000502:physiology*; D012038:Regeneration; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering; D014070:Tooth / Q000502:physiology*
D006133:Growth Substances