title: Determination of vascular-endothelial growth factor levels in serum from tumor-bearing BALB/c mice treated with photodynamic therapy.
abstract: METHODS
  We implanted a malignant tumour, BFS1 fibrosarcoma, into BALB/c mice and then treated them using a new photosensitizer, hydroxygallium (III) phthalocyanine tetrasulfonic acid tetrasodium salt, BON-6. The administration of this compound was followed by light irradiation using a halogen lamp at 680 nm. VEGF concentrations were measured in sera from the mice and compared to the time of tumor growth.
  
  
  RESULTS
  BON-6 was found to be effective in PDT. This feature was accompanied by low levels of VEGF after BON-6+PDT, and also prolongation of the time of survival of treated animals. The mice which received BON-6+PDT survived 83.8 days (SD 10.23). The mean survival time in control groups did not exceed 35 days. Additionally, measurement of tumor size showed total regression in single cases after BON-6+PDT.
  
  
  CONCLUSIONS
  PDT, by decreasing VEGF serum levels, may influence the capability of tumor tissue to form new vessels.
authors.affiliation: Department of Pathology, Medical University, Wrocław, Poland.
authors.forename: Beata J
authors.initials: BJ
authors.lastname: Osiecka
authors.forename: Piotr
authors.initials: P
authors.lastname: Ziołkowski
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Gamian
authors.forename: Anna
authors.initials: A
authors.lastname: Lis-Nawara
authors.forename: Stephen G
authors.initials: SG
authors.lastname: White
authors.forename: Raymond
authors.initials: R
authors.lastname: Bonnett
mesh_terms: D000818:Animals; D016228:Endothelial Growth Factors / Q000097:blood*; D005354:Fibrosarcoma / Q000097:blood / Q000188:drug therapy*; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008222:Lymphokines / Q000097:blood*; D051379:Mice; D008807:Mice, Inbred BALB C; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D009942:Organometallic Compounds; D010778:Photochemotherapy; D015996:Survival Rate; D013997:Time Factors; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D009942:Organometallic Compounds; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; C475999:hydroxygallium (III) phthalocyanine tetrasulfonic acid tetrasodium salt