[Changes of urinary tripsin inhibitor in blood and urine, as well as serum cytokines in living related liver transplantation].
BACKGROUND
Living related liver transplantation induces the production of many inflammatory and anti-inflammatory cytokines. Urinary tripsin inhibitor (UTI) is produced in the liver and wellknown as one of the markers of surgical stress.


METHODS
To clarify the significance of UTI in blood and urine and serum cytokines in living related liver transplantation, we examined the changes of UTI, polymorphonuclear elastase (PMNE), interleukin (IL)-6, IL-1 ra and IL-10 perioperatively.


RESULTS
UTI in blood increased gradually after operation. It increased from 5.2 +/- 2.2 U.ml-1 at the end of operation to 19.4 +/- 7.5 U.ml-1 on the 10 th postoperative day (POD). Similarly, UTI in urine increased after operation and the peak was on the 7th POD. Cytokines including IL-6, IL-1 ra and IL-10 showed similar changes in general gastrointestinal surgery, but the peak values in liver transplantation were lower.


CONCLUSIONS
These results demonstrate that the recovery of the transplanted liver function require certain time after operation and UTI in urine could be an important marker whether the liver is working or not. The immunosuppressive drugs, like steroid, administered during and after operation would suppress the production of cytokines.
Matsumi
Masaki
M
Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558.
Mizobuchi
Satoshi
S
Kaku
Ryuji
R
Ohashi
Ichiro
I
Nakatsuka
Hideki
H
Katayama
Hiroshi
H
D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D016207:Cytokines / Q000097:blood*; D005260:Female; D006023:Glycoproteins / Q000097:blood* / Q000652:urine*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D018836:Inflammation Mediators / Q000097:blood* / Q000652:urine*; D019272:Leukocyte Elastase / Q000097:blood; D008099:Liver / Q000502:physiology*; D016031:Liver Transplantation / Q000009:adverse effects; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care; D013312:Stress, Physiological / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D013997:Time Factors; D014022:Tissue Survival
D015415:Biomarkers; D016207:Cytokines; D006023:Glycoproteins; D007166:Immunosuppressive Agents; D018836:Inflammation Mediators; D019272:Leukocyte Elastase; C028665:urinastatin