Patterning systems--from one end of the limb to the other.
A combination of embryology and gene identification has led us to the current view of vertebrate limb development, in which a series of three interlocking patterning systems operate sequentially over time. This review describes current understanding of these regulatory mechanisms and how they form a framework for future analysis of limb patterning.
Tickle
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Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD15EH, United Kingdom. c.a.tickle@dundee.ac.uk
D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D005121:Extremities / Q000196:embryology*; D005385:Fingers / Q000196:embryology; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D006133:Growth Substances / Q000235:genetics / Q000378:metabolism; D053823:Hedgehog Proteins; D006801:Humans; D008648:Mesoderm / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D014714:Vertebrates / Q000196:embryology*
D006133:Growth Substances; D053823:Hedgehog Proteins; D015534:Trans-Activators