title: [Evaluation of endothelial permeability in brain tumors by dynamic magnetic resonance tomography with magnevist contrast imaging on low-field MR-tomograph].
abstract: In order to study the endothelial permeability to hydrophilic macromolecules in brain tumors we have developed a technique based on Gjedde-Rutland-Patlak approach to dynamic MRI study with Gd-DTPA injected intravenously, performed with low-field MRI tomograph Magnetom Open (Siemens medical). 27 patients with various brain tumors were referred for the study. The indices of Gd-DTPA transport to tumor tissue (KGd-DTPA) vary substantially, depending on the degree of malignancy and deliver essential information on microvascular permeability of tumor capillary bed.
authors.affiliation: Research Institute of Cardiology, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk Regional Clinical Hospital.
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Usov
authors.forename: O B
authors.initials: OB
authors.lastname: Velichko
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Borodin
authors.forename: A B
authors.initials: AB
authors.lastname: Garganeev
authors.forename: A A
authors.initials: AA
authors.lastname: Shikunov
authors.forename: O N
authors.initials: ON
authors.lastname: Boklag
mesh_terms: D000236:Adenoma / Q000175:diagnosis; D001254:Astrocytoma / Q000175:diagnosis; D001932:Brain Neoplasms / Q000175:diagnosis; D002199:Capillary Permeability; D016543:Central Nervous System Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D004806:Ependymoma / Q000175:diagnosis; D019786:Gadolinium DTPA; D005910:Glioma / Q000175:diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D008577:Meningeal Neoplasms / Q000175:diagnosis; D008579:Meningioma / Q000175:diagnosis; D010911:Pituitary Neoplasms / Q000175:diagnosis
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA
vernacular_title: Otsenka endotelial'noĭ pronitsaemosti opukholeĭ mozga metodom dinamicheskoĭ magnitno-rezonansnoĭ tomografii s kontrastirovaniem Magnevistom na nizkopol'nom MR-tomografe..