Modulating macrophage function with IgG immune complexes.
Macrophages respond to bacterial products by releasing a large array of inflammatory mediators. We demonstrate that, in the presence of IgG immune complexes, macrophages produce high levels of IL-10 and virtually no IL-12, when they are exposed to bacterial products. The production of IL-10 by these cells can dampen innate inflammatory responses to microbial products, such as LPS. This alteration in macrophage cytokine production can also influence an adaptive immune response, preferentially inducing Th2-type immunity. Thus, immune complexes change the physiology of activated macrophages, converting them to anti-inflammatory cells that induce Th2-like immune responses. We have termed these cells type II activated macrophages.
Anderson
Charles F
CF
Cell Biology and Molecular Genetics, University of Maryland, College Park 20742, USA.
Gerber
Jeffrey S
JS
Mosser
David M
DM
D000936:Antigen-Antibody Complex / Q000276:immunology*; D001854:Bone Marrow Cells; D018929:Cell Culture Techniques; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007249:Inflammation; D016753:Interleukin-10 / Q000096:biosynthesis; D018664:Interleukin-12 / Q000096:biosynthesis; D008264:Macrophages / Q000276:immunology*; D018418:Th2 Cells
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D016753:Interleukin-10; D018664:Interleukin-12