Protein homeostasis: a degrading role for Int6/eIF3e.
Similarities between the three related "PCI" complexes--eIF3, the COP9 signalosome and the proteasome lid--have hinted at novel pathways controlling protein homeostasis. Recent experiments with fission yeast have begun to weigh in with genetic evidence.
von Arnim
Albrecht G
AG
Department of Botany, The University of Tennessee, Knoxville, TN 37996, USA.
Chamovitz
Daniel A
DA
D000818:Animals; D039621:Eukaryotic Initiation Factor-3 / Q000235:genetics / Q000378:metabolism*; D019143:Evolution, Molecular; D019204:GTP-Binding Proteins / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology*; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D010447:Peptide Hydrolases / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D015398:Signal Transduction
D039621:Eukaryotic Initiation Factor-3; D010447:Peptide Hydrolases; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease; D019204:GTP-Binding Proteins