title: Angiographic characteristics in patients undergoing macular translocation for subfoveal choroidal neovascularization secondary to age-related macular degeneration.
abstract: OBJECTIVE
  To review in a standardized fashion pre- and postoperative fluorescein angiographic characteristics in patients undergoing limited macular translocation (LMT) with scleral imbrication to treat subfoveal choroidal neovascularization (SFCNV) secondary to age-related macular degeneration (AMD). The current study was undertaken to assess any potential effects of the translocation procedure on altering the angiographic characteristics of SFCNV before laser photocoagulation.
  
  
  METHODS
  A consecutive series of patients undergoing LMT for AMD was identified retrospectively. The pre- and postoperative fluorescein angiograms were reviewed in a masked fashion. Angiographic characteristics evaluated included pre- and postoperative lesion components, stability of lesion, and the amount of retinal translocation obtained.
  
  
  RESULTS
  Eighty-eight patients (90 eyes) had angiograms of adequate quality to permit evaluation. Time between the preoperative and the prelaser angiogram ranged from 2 to 84 days (median 7.5 days). Neovascular complexes remained unchanged or decreased in size in 79% of patients. There was no statistically significant difference in lesion size between the pre- and postoperative periods (P = 0.34). Retinal movement ranged from 160 microm to 3,320 microm (median 960 microm), with 61% of cases undergoing effective translocation (i.e., the fovea was moved away from the neovascular complex). None of the lesion components or demographic factors evaluated affected the amount of translocation obtained. Larger lesions were more likely to remain subfoveal following translocation (P = 0.004).
  
  
  CONCLUSIONS
  The size and lesion characteristics appear relatively stable following translocation. Amount of retinal movement is not associated with angiographic lesion characteristics. Only size was associated with achievement of desired translocation in the final model, with large lesions being less likely to achieve desired translocation. In our study group, the amount of retinal translocation was variable with 61% of cases undergoing effective translocation.
authors.affiliation: Vitreoretinal Service, Wilmer Institute, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: David L
authors.initials: DL
authors.lastname: Kent
authors.forename: Gildo Y
authors.initials: GY
authors.lastname: Fujii
authors.forename: Dante J
authors.initials: DJ
authors.lastname: Pieramici
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Reynolds
authors.forename: Michele
authors.initials: M
authors.lastname: Melia
authors.forename: Juliana V
authors.initials: JV
authors.lastname: Rossi
authors.forename: Mark S
authors.initials: MS
authors.lastname: Humayun
authors.forename: Sean
authors.initials: S
authors.lastname: Caffey
authors.forename: Eugene
authors.initials: E
authors.lastname: De Juan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016342:Angioplasty, Laser / Q000379:methods; D020256:Choroidal Neovascularization / Q000473:pathology / Q000601:surgery*; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000473:pathology; D006801:Humans; D008266:Macula Lutea / Q000637:transplantation*; D008268:Macular Degeneration / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D011183:Postoperative Complications / Q000175:diagnosis; D011859:Radiography; D012160:Retina / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D013997:Time Factors