title: Serum lipids of pemphigus foliaceus patients on long-term glucocorticoid therapy.
abstract: Endemic pemphigus foliaceus, and long-term corticotherapy may affect serum lipid levels. The aim of this study was to compare serum lipids of pemphigus foliaceus patients on glucocorticoid therapy to a healthy control group. Fifteen patients receiving prednisone (0.33 +/- 0.22 mg/kg) for at least 12 months and 15 controls were submitted to 48-h food intake records, anthropometry, and biochemical measurements. Data were compared by chi2, Mann-Whitney and Student "t" tests. The groups were matched for gender, age, weight, body mass index, arm circumference and triceps skin fold. No differences were observed in relation to energy, fat, protein and carbohydrate daily intakes, total cholesterol, HDL, LDL, uric acid, and serum creatinine levels. Pemphigus foliaceus patients had higher triglyceride [159 (64-371) vs. 100 (45-133) mg/dl], VLDL [32 (13-74) vs. 20 (9-114) mg/dl] and ESR [44 (9-87) vs. 7 (1-30) mm/h] levels than controls, probably due to metabolic effects of inflammatory disease and corticotherapy.
authors.affiliation: Department of Internal Medicine, Faculdade de Medicina do Triângulo Mineiro, Uberaba.
authors.forename: Selma Freire de Carvalho
authors.initials: SF
authors.lastname: da Cunha
authors.forename: Vitorino Modesto
authors.initials: VM
authors.lastname: dos Santos
authors.forename: Jacqueline Pontes
authors.initials: JP
authors.lastname: Monteiro
authors.forename: Tácio Pierre Sousa
authors.initials: TP
authors.lastname: Ferreira
authors.forename: Jenner Arruda Modesto
authors.initials: JA
authors.lastname: dos Santos
authors.forename: Taciana Arruda Modesto
authors.initials: TA
authors.lastname: dos Santos
authors.forename: Daniel Ferreira
authors.initials: DF
authors.lastname: da Cunha
mesh_terms: D001799:Blood Sedimentation / Q000187:drug effects; D016022:Case-Control Studies; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D010392:Pemphigus / Q000097:blood* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D008055:Lipids; D011241:Prednisone