Influence of repetitive Gz acceleration on structural and metabolic profile of m. vastus lateralis in monkeys exposed to 30 day bedrest.
It was shown that changes in structural and metabolic indices of extensor muscles of the lower extremities were usually found in man after exposure to space flight or to bed rest. Similar changes were also observed in monkeys, space-flown on "Kosmos" biosatellites. Response to weightlessness and to restraint was found to be different in m. soleus and in m. vastus lateralis. Therefore, it is important to study structural and metabolic changes of m. vastus lateralis fibers under conditions of gravitational unloading in monkeys, who have motor apparatus similar to that of man, and are much more fruitful object of research. It is assumed that artificial gravity can serve as a countermeasure, aimed at diminishing effects of gravitational unloading. We have studied the effect of repeated gravity overloading, created by means of a centrifuge, on structural and metabolic indices of monkey m. vastus lateralis at the background of 30 day head down tilt bed rest (BR).
Belozerova
I N
IN
SRC-Institute for Biomedical Problems, I.M. Sechenov Moscow Medical Academy, Moscow, Russia.
Matveeva
O A
OA
Kuznetsov
S L
SL
Nemirovskaya
T L
TL
Shenkman
B S
BS
D000054:Acceleration; D000818:Animals; D001510:Bed Rest; D002498:Centrifugation; D018475:Head-Down Tilt; D018471:Hypergravity; D008253:Macaca mulatta; D008297:Male; D018656:Muscle Fibers, Fast-Twitch / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D018657:Muscle Fibers, Slow-Twitch / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology*; D018544:Weightlessness Countermeasures