The detection of non-adherence by self-administered questionnaires can be optimized by protease inhibitor plasma concentration determination.
Self-reported adherence and plasma protease inhibitor concentration (PPIC) were assessed in 642 HIV-infected patients at month 4 of a single protease inhibitor-containing regimen. PPIC was below the limit of quantification (LOQ) in 32% of non-adherent patients and in 8% of adherent patients. The relationship between non-adherence and a detectable HIV viral load was enhanced when adherent patients with PPIC below LOQ were considered to be non-adherent. PPIC combined with self-report may more reliably detect non-adherence.
Duran
Ségolène
S
INSERM U379, Marseille, France.
Peytavin
Gilles
G
Carrieri
Patrizia
P
Raffi
François
F
Ecobichon
Jean-Luc
JL
Pereira
Edwige
E
Cassuto
Gilles Patrice
GP
Spire
Bruno
B
Leport
Catherine
C
D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D010349:Patient Compliance; D012650:Self Disclosure; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D019562:Viral Load
D017320:HIV Protease Inhibitors