LDL receptor-related proteins in neurodevelopment.
Low-density lipoprotein receptor-related proteins (LRPs) are evolutionarily ancient cell-surface receptors with diverse biological functions. All are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family. Here, we will summarize recent advances in our understanding of the molecular basis on which these receptors function during development.
May
Petra
P
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.
Herz
Joachim
J
D000818:Animals; D006801:Humans; D026502:LDL-Receptor Related Proteins; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000502:physiology*; D026561:Low Density Lipoprotein Receptor-Related Protein-2 / Q000502:physiology*; D005810:Multigene Family / Q000502:physiology; D009420:Nervous System / Q000196:embryology; D017433:Protein Structure, Secondary; D011973:Receptors, LDL / Q000502:physiology; D018110:Receptors, Lipoprotein / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D026502:LDL-Receptor Related Proteins; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D026561:Low Density Lipoprotein Receptor-Related Protein-2; D011973:Receptors, LDL; D018110:Receptors, Lipoprotein; C036053:VLDL receptor; C098773:low density lipoprotein receptor-related protein 8