[Increased sP-selectin and other cardiovascular risk factors: fibrinogen, tissue plasminogen activator (t-PA Ag) and acute phase proteins after kidney transplantation].
BACKGROUND
Our study was designed to monitor the presence of the "coronary artery disease (CAD) risk factors" after kidney transplantation.


METHODS
26 kidneys transplant recipients with well-functioning (creatinine clearance > 0.8 mL/s) renal allografts receiving cyclosporine A (CsA) as the basic component of immunosuppressive therapy and 60 healthy age-matched controls were included into the study. As "CAD risk factors" were determined the levels of fibrinogen, acute phase proteins orosomucoid and C-reactive protein, t-PA Ag, PAI-1 Ag and soluble adhesion molecules E-selectin, P-selectin and ICAM-1 in the peripheral blood serum or plasma.


RESULTS
Renal transplant recipients showed higher BMI (p < 0.001) and levels of fibrinogen (p < 0.001), t-PA Ag (p = 0.007) and PAI-1 Ag (p < 0.001), acute phase protein orosomucoid (p < 0.001) and higher level of soluble P-selectin (p = 0.038). The levels of sICAM-1 and sE-selectin did not differ statistically significantly from those in controls.


CONCLUSIONS
Our study has demonstrated renal graft recipients with good kidney function already show significantly raised levels of "CAD risk factors" fibrinogen, acute phase reactant orosomucoid, t-PA Ag, PAI-1 Ag and sP-selectin.
Kvasnicka
J
J
I. interní klinika 1. lékarské fakulty Univerzity Karlovy, U nemocnice 1, 128 08 Praha 2, Czech Republic. kvasnic@okhvfn.anet.cz
Viklický
O
O
Umlaufová
A
A
Kvasnicka
T
T
Teplá
E
E
Homolková
H
H
Malíkova
I
I
Sauerová
R
R
D000209:Acute-Phase Proteins / Q000032:analysis*; D003327:Coronary Disease / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D012307:Risk Factors; D010959:Tissue Plasminogen Activator / Q000097:blood
D000209:Acute-Phase Proteins; D019007:P-Selectin; D017395:Plasminogen Activator Inhibitor 1; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator
Zvýsení sP-selektinu a dalsích kardiovaskulárních rizikových faktorů: fibrinogenu, tkánového aktivátoru plasminogenu (t-PA Ag), jeho inhibitoru (PAI-1 Ag) a proteinů akutní fáze u nemocných po transplantaci ledviny.