title: Intrathecal methotrexate-induced acute cerebellar syndrome.
abstract: Intrathecal application of chemotherapeutics has been the mainstay of central nervous system prophylaxis in acute lymphoblastic leukemia treatment. We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously. To our knowledge, this is the first case of methotrexate-related acute cerebellar syndrome.
authors.affiliation: Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. bferhan@superonline.com
authors.forename: B
authors.initials: B
authors.lastname: Ferhanoglu
authors.forename: S
authors.initials: S
authors.lastname: Ongören
authors.forename: C M
authors.initials: CM
authors.lastname: Ar
authors.forename: B
authors.initials: B
authors.lastname: Uzel
authors.forename: H
authors.initials: H
authors.lastname: Forta
authors.forename: D
authors.initials: D
authors.lastname: Necioglu
mesh_terms: D000208:Acute Disease; D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D002526:Cerebellar Diseases / Q000139:chemically induced*; D003422:Critical Care; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate