Effects of fibrinogen on lipid peroxidation in patients with coronary heart disease and in vitro.
In patients with coronary heart disease oxidizability of lipids during Cu(2+)-induced oxidation of blood plasma inversely correlated with fibrinogen content. A positive correlation was found between the amount of lipid peroxidation products in the plasma from these patients and fibrinogen content. The increase in fibrinogen content was associated with high levels of total lipids and triglycerides and low concentration of high-density lipoprotein cholesterol. In vitro experiments demonstrated that fibrinogen reduces oxidizability of blood plasma. Our results suggest that the decrease in lipid oxidizability at high concentration of fibrinogen in patients with coronary heart disease is related to predominant oxidation of fibrinogen and its competition with plasma lipids during Cu(2+)-induced oxidation.
Savchenkova
A P
AP
Institute of Physicochemical Medicine, Russian Ministry of Health, Moscow.
Dudnik
L B
LB
Pogoretskaya
I L
IL
Solov'eva
N P
NP
Pokrovskaya
M A
MA
Aseichev
A V
AV
Drinitsyna
S V
SV
Azizova
O A
OA
Lopukhin
Yu M
YM
D003327:Coronary Disease / Q000097:blood / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism; D018384:Oxidative Stress
D008054:Lipid Peroxides; D005340:Fibrinogen