title: [Hypermethylation status of blu gene in nasopharyngeal lymphoma].
abstract: OBJECTIVE
  To investigate the hypermethylation status of blu gene promoter in nasopharyngeal NK/T cell lymphoma and its role in the tumorigenesis and molecular diagnosis of this lymphoma.
  
  
  METHODS
  Twenty cases of paraffin-embedded nasopharyngeal NK/T cell lymphomas tissues were studied by using methylation specific PCR (MSP).
  
  
  RESULTS
  Hypermethylation of blu gene promoter is detected in 6 of 20 (30%) nasopharyngeal NK/T cell lymphoma. The 6 positive cases were 4 in 15 nasopharyngeal NK cell lymphomas, 1 of 2 NK like T cell lymphoma and 1 in 3 peripheral T cell lymphomas (unspecified type).
  
  
  CONCLUSIONS
  Hypermethylation of blu gene promoter in nasopharyngeal NK/T cell lymphoma indicated the inactivation of blu gene and its possible role in the tumorigenesis of this lymphoma. blu gene methylation could be detected in paraffin-embedded tissue and used as a new molecular marker for the diagnosis of this lymphoma.
authors.affiliation: Department of Pathology, Peking University Health Science Center, Beijing 100083, China.
authors.forename: Xiao-hua
authors.initials: XH
authors.lastname: Zhang
authors.forename: Fen
authors.initials: F
authors.lastname: Jiang
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Tao
authors.forename: Zi-fen
authors.initials: ZF
authors.lastname: Gao
mesh_terms: D003598:Cytoskeletal Proteins; D019175:DNA Methylation; D016147:Genes, Tumor Suppressor; D006801:Humans; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D016133:Polymerase Chain Reaction / Q000379:methods; D025521:Tumor Suppressor Proteins
chemical_list: D003598:Cytoskeletal Proteins; D025521:Tumor Suppressor Proteins; C472720:ZMYND10 protein, human