title: [In vitro susceptibility of different erythromycin-resistant phenotypes of Streptococcus pyogenes to moxifloxacin and other fluoroquinolones]
abstract: The aim of the present study was to evaluate the in vitro activity of moxifloxacin (BAY 12-8039) compared with ciprofloxacin, ofloxacin and sparfloxacin against 156 Group A beta-haemolytic Streptococcus (GABHS) strains. Sixty strains were macrolide- lincosamide- and streptogramin B susceptible; 16 strains exhibited a constitutive resistance phenotype; 32 strains exhibited an inducible phenotype; and 48 strains were characterized by the M-type efflux-dependent phenotype. The MICs were determined by an agar dilution method according to NCCLS-approved guidelines. Moxifloxacin showed an enhanced activity compared with the other fluoroquinolones against all the different macrolide-resistant phenotypes.
authors.affiliation: Clinica Malattie Infettive, Seconda Universita degli Studi di Napoli, Italia.
authors.forename: S.
authors.initials: S
authors.lastname: Novielllo
authors.forename: F.
authors.initials: F
authors.lastname: Ianniello
authors.forename: S.
authors.initials: S
authors.lastname: Esposito
authors.forename: A.
authors.initials: A
authors.lastname: Novelli
vernacular_title: Sensibilita in vitro di differenti fenotipi di Streptococcus pyogenes eritromicina-resistenti a moxifloxacina ed altri fluorochinoloni.