title: Different chromogranin immunoreactivity between prion and a-beta amyloid plaque.
abstract: Brain lesions in Creutzfeldt-Jakob disease (CJD) include spongiform change, neuronal loss, amyloid plaques, astrogliosis and microglial activation. Microglia are thought to play a key role in prion-induced neurodegeneration. However, the intermediate molecules supporting relationships between neurons and microglia are still unknown. Chromogranins (Cg) are soluble glycophosphoproteins that can activate microglial cells leading to a neurotoxic phenotype. The immunoreactive patterns of CgA and CgB were investigated in CJD and compared to those observed in Alzheimer's disease. We found that CgB, but not CgA, immunoreactivity was selectively associated with prion protein deposits, whereas CgA was only seen in Abeta plaques. This suggests a specific influence of the constitutive amyloid protein on chromogranin secretion and a role of CgB in the CJD neurodegenerative process.
authors.affiliation: INSERM Unité 338, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France.
authors.forename: Claire-Marie
authors.initials: CM
authors.lastname: Rangon
authors.forename: Stéphane
authors.initials: S
authors.lastname: Haïk
authors.forename: Baptiste A
authors.initials: BA
authors.lastname: Faucheux
authors.forename: Marie-Helène
authors.initials: MH
authors.lastname: Metz-Boutigue
authors.forename: Françoise
authors.initials: F
authors.lastname: Fierville
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Fuchs
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Hauw
authors.forename: Dominique
authors.initials: D
authors.lastname: Aunis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism / Q000473:pathology; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism*; D007562:Creutzfeldt-Jakob Syndrome / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D016501:Neurites / Q000473:pathology; D058225:Plaque, Amyloid / Q000378:metabolism* / Q000473:pathology; D011328:Prions / Q000378:metabolism*; D013702:Temporal Lobe / Q000378:metabolism / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; D053379:Chromogranin A; D002864:Chromogranins; D011328:Prions