CD20 is associated with a small mature plasma cell morphology and t(11;14) in multiple myeloma.
CD20 has been reinvestigated in 66 patients with multiple myeloma (MM). Twelve of the patients (18%) expressed CD20, including 5 of 50 patients at diagnosis presenting 100% CD20+ cells. Seven (58%) of 12 CD20+ patients with MM had a small mature plasma cell morphology as opposed to 4 (7%) of 54 with CD20- MM (P =.0001). Of note, 10 (83%) of 12 patients with CD20+ MM had t(11;14) as opposed to 5 of 54 (9%) CD20- patients (P <.001). All the patients with 100% CD20+ cells presented with t(11;14) and 4 of 5 with a small mature plasma cell morphology. Thus, 66% of the patients with t(11;14) expressed CD20, whereas only 4% of the 51 patients lacking such translocation expressed CD20 (P <.0001). In conclusion, CD20 expression is associated with small mature plasma cell morphology and with t(11;14) in patients with MM.
Robillard
Nelly
N
Laboratory of Hematology and Institut National de la Santé et de la Recherche Médicale (INSERM) U463, Institute of Biology, Nantes, France.
Avet-Loiseau
Herve
H
Garand
Richard
R
Moreau
Philippe
P
Pineau
Danielle
D
Rapp
Marie-Josee
MJ
Harousseau
Jean-Luc
JL
Bataille
Regis
R
D018951:Antigens, CD20 / Q000032:analysis*; D048429:Cell Size; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D010950:Plasma Cells / Q000473:pathology*; D011446:Prospective Studies; D013223:Statistics as Topic; D014178:Translocation, Genetic
D018951:Antigens, CD20