title: Centbucridine, a newer topical anaesthetic compared with lignocaine: a randomized double masked single drop instillation clinical trial.
abstract: A randomized double-masked single drop instillation clinical trial was conducted on 60 healthy volunteers divided into 3 equal groups to compare the efficacies of centbucridine and lignocaine. One eye of each volunteer was instilled with a single drop of either 0.5% centbucridine hydrochloride, 1% centbucridine hydrochloride or 4% lignocaine hydrochloride, with the other eye as an unanaesthetized control-side effects, if any, were also recorded. The onset of anaesthesia assessed both objectively and subjectively, was quickest with lignocaine 4% (P < 0.001) followed by centbucridine 0.5% and 1%. However, the period of peak activity as well as the total duration of surface anaesthesia, and also the depth of analgesia, were significantly highest with 1% centbucridine, followed by 0.5% centbucridine and 4% lignocaine respectively. Minor side effects like burning sensations were longest with 1% centbucridine--no significant adverse effects, local or systemic, were observed. Prolonged surface anaesthetic and analgesic actions of centbucridine 1% may be advantages for longer duration ophthalmic microsurgeries.
authors.affiliation: Division of Ocular Pharmacology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi-110 029.
authors.forename: Nihar Ranjan
authors.initials: NR
authors.lastname: Biswas
authors.forename: Basant
authors.initials: B
authors.lastname: Verma
authors.forename: Supriyo
authors.initials: S
authors.lastname: Ghose
authors.forename: Gopal Krushna
authors.initials: GK
authors.lastname: Das
authors.forename: Sarita
authors.initials: S
authors.lastname: Beri
authors.forename: Ravindra Mohan
authors.initials: RM
authors.lastname: Pandey
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000704:Analysis of Variance; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000737:chemistry; D004311:Double-Blind Method; D005123:Eye / Q000187:drug effects*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000737:chemistry; D013619:Tacrine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000779:Anesthetics, Local; D009883:Ophthalmic Solutions; D013619:Tacrine; C037014:centbucridine; D008012:Lidocaine