Structural biology of hepatitis C virus.
Structural analyses of hepatitis C virus (HCV) components provide an essential framework for understanding the molecular mechanisms of HCV polyprotein processing, RNA replication, and virion assembly. They are central, moreover, to the elucidation of interactions of HCV proteins with the host cell and may contribute to a better understanding of the pathogenesis of hepatitis C. Ultimately, these analyses should allow for identifying novel targets for antiviral intervention and for developing new strategies to prevent and combat viral hepatitis.
Penin
François
F
Institute of Biology and Chemistry of Proteins, UMR 5086, Centre National de la Recherche Scientifique/UCB 7, Passage du Vercors 69367, Lyon 07, France. f.penin@ibcp.fr
D000818:Animals; D014644:Genetic Variation / Q000502:physiology; D016679:Genome, Viral; D016174:Hepacivirus / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006526:Hepatitis C / Q000821:virology; D006801:Humans; D008958:Models, Molecular; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism; D014779:Virus Replication / Q000502:physiology
D014764:Viral Proteins