title: Subcutaneous panniculitis-like T-cell lymphoma: complete remission with fludarabine.
abstract: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an uncommon type of cutaneous lymphoma with an aggressive natural history. It generally carries a poor prognosis despite standard anthracycline-based chemotherapy. The optimum therapy is unknown. We report the case of a 66-year-old man with CD4/CD8 double negative SPTCL who achieved a complete remission with single-agent fludarabine. He received a total of six cycles of fludarabine given at 25 mg/m(2) daily for 5 days every 4 weeks. His skin ulcers started to heal within 2 weeks of the first cycle of chemotherapy and were completely healed before the fourth cycle. Unfortunately, he died suddenly of unknown cause 3 months after the completion of chemotherapy while remaining in complete remission. Our report suggests that fludarabine may be an active agent in SPTCL and deserves further study.
authors.affiliation: Section of Hematology, Gundersen Lutheran Medical Center, Founders Building, 1836 South Avenue, La Crosse,WI 54601, USA. rsgo@gundluth.org
authors.forename: R S
authors.initials: RS
authors.lastname: Go
authors.forename: H
authors.initials: H
authors.lastname: Gazelka
authors.forename: J D
authors.initials: JD
authors.lastname: Hogan
authors.forename: S M
authors.initials: SM
authors.lastname: Wester
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008297:Male; D009336:Necrosis; D015434:Panniculitis / Q000175:diagnosis / Q000188:drug therapy; D014740:Vidarabine / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D014740:Vidarabine; C024352:fludarabine