High dose therapy with autologous stem cell transplantation for solitary bone plasmacytoma complicated by local relapse or isolated distant recurrence.
We report three patients with solitary bone plasmacytoma (SBP) who developed either local recurrence within the radiotherapy field or an isolated distal recurrence and who were treated with high dose therapy supported by autologous stem cell transplantation. All patients remain without evidence of disease for 4-10 years after the procedure. High dose therapy may be of value and require further study in patients with SBP who develop local or distant failure.
Dimopoulos
Meletios A
MA
Department of Clinical Therapeutics, University of Athens, School of Medicine, Athens, Greece. mdimop@med.uoa.gr
Papadimitriou
Christos
C
Anagnostopoulos
Athanassios
A
Mitsibounas
Dimitrios
D
Fermand
Jean-Paul
JP
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000175:diagnosis / Q000628:therapy*; D018572:Disease-Free Survival; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D010954:Plasmacytoma / Q000175:diagnosis / Q000628:therapy*; D018714:Radiotherapy, Adjuvant; D012008:Recurrence; D014182:Transplantation, Autologous