title: [Clinical trial of the month. The STENO-2 study: a plea for global and intensive management of the type 2 diabetic patient].
abstract: Cardiovascular morbidity is a major burden in patients with type 2 diabetes. The Steno-2 Study compared the effect of a targeted, intensified, multifactorial intervention (n = 80) with that of a conventional treatment (n = 80) on modifiable risk factors for cardiovascular disease in patients with type 2 diabetes and microalbuminuria. After a mean follow-up of 7.8 years, the risk of cardiovascular events was reduced by 53% in the intensive group, and the risk of microvascular events (nephropathy, retinopathy, autonomic neuropathy) by 58-63%. Thus, a target-driven, long-term, intensified intervention aimed at multiple risk factors should be recommended in patients with type 2 diabetes and microalbuminuria.
authors.affiliation: Service de Diabétologie, Nutrition et Maladies métaboliques et de Médecine interne générale, Département de Médecine, CHU Sart Tilman, Liège.
authors.forename: A J
authors.initials: AJ
authors.lastname: Scheen
authors.forename: F
authors.initials: F
authors.lastname: Estrella
mesh_terms: D000419:Albuminuria / Q000150:complications; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D003925:Diabetic Angiopathies / Q000209:etiology / Q000517:prevention & control*; D003928:Diabetic Nephropathies / Q000209:etiology / Q000517:prevention & control*; D003930:Diabetic Retinopathy / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
vernacular_title: L'étude clinique du mois. L'étude Steno-2: plaidoyer pour une prise en charge globale et intensive du patient diabétique de type 2.