YM-266183 and YM-266184, novel thiopeptide antibiotics produced by Bacillus cereus isolated from a marine sponge II. Structure elucidation.
YM-266183 and YM-266184 are new antibacterial substances that have activity against drug-resistant bacteria produced by Bacillus cereus QN03323. These structures were elucidated by MS and NMR spectral analysis. YM-266183 and YM-266184 are the cyclic thiopeptides containing thiazole and pyridine moieties, and several unusual amino acids.
Suzumura
Ken-ichi
K
Analysis & Metabolism Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 21 Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan. nagai@yamanouchi.co.jp
Yokoi
Takako
T
Funatsu
Masashi
M
Nagai
Koji
K
Tanaka
Koichi
K
Zhang
Huiping
H
Suzuki
Kenichi
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001409:Bacillus cereus / Q000378:metabolism*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry*; D011161:Porifera / Q000382:microbiology; D011725:Pyridines / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013844:Thiazoles / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D010455:Peptides; D010456:Peptides, Cyclic; D011725:Pyridines; D013844:Thiazoles; C474182:YM 266183; C474183:YM 266184