title: Yeast POL5 is an evolutionarily conserved regulator of rDNA transcription unrelated to any known DNA polymerases.
abstract: We show that yeast protein Yel055cp, which has been identified as the fifth essential DNA polymerase in Saccharomyces cerevisiae (POL5), is a member of a family of predicted rDNA transcription regulators (typified by human MYB-binding protein MYBBP1 A), which are represented by a single ortholog in all animals, fungi and plants with sequenced genomes. These proteins are confidently predicted to have an entirely a-helical structure and are unrelated to the B class DNA polymerases, as claimed for yeast POL5, or any other known polymerases.
authors.affiliation: National Center for Biotechnology Inforamtion, National Library of Medicine, National Institutes of Health; Bethesda, Maryland 20894, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Igor B
authors.initials: IB
authors.lastname: Rogozin
authors.forename: Eugene V
authors.initials: EV
authors.lastname: Koonin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D004275:DNA, Ribosomal / Q000235:genetics; D004259:DNA-Directed DNA Polymerase / Q000145:classification* / Q000235:genetics* / Q000502:physiology; D019143:Evolution, Molecular; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D008969:Molecular Sequence Data; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000145:classification / Q000235:genetics* / Q000502:physiology; D016415:Sequence Alignment; D014158:Transcription, Genetic
chemical_list: D004275:DNA, Ribosomal; D029701:Saccharomyces cerevisiae Proteins; D004259:DNA-Directed DNA Polymerase; C482399:POL5 protein, S cerevisiae