Ab initio protein phasing at 1.4 A resolution.
All the techniques today available for the ab initio crystal structure solution of proteins require that the atomicity condition is satisfied. Accordingly, diffraction data at resolution equal or better than 1.2 A are necessary. This condition reduces the role of the ab initio techniques in macromolecular crystallography. The computer program SIR2002 has been modified in such a way that it may succeed also with 1.4 A resolution diffraction data. The modifications concern all the modules of the program: the modified program also benefits by the efficiency of a figure of merit.
Burla
Maria C
MC
Dipartimento di Scienze della Terra, Piazza Università, 06100 Perugia, Italy.
Carrozzini
Benedetta
B
Cascarano
Giovanni L
GL
De Caro
Liberato
L
Giacovazzo
Carmelo
C
Polidori
Giampiero
G
D003094:Collagen / Q000737:chemistry; D003461:Crystallography / Q000379:methods; D007768:Lactalbumin / Q000737:chemistry; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry*; D012680:Sensitivity and Specificity; D012984:Software
D011506:Proteins; D003094:Collagen; D007768:Lactalbumin