[Paraneoplastic neurologic syndrome and small-cell lung cancer in a patient positive for anti-Hu antigen].
We encountered a case of small-cell lung cancer with paraneoplastic neurologic syndrome in a 68-year old man. Progressive dysesthesia had developed in his hands and legs over a period of 4 months. Chest radiography and chest CT scanning on admission showed a mass in the hilum of the left lung. Anti-Hu antibody was found in his serum and the subsequent histopathological diagnosis by TBLB was small cell lung cancer. The patient underwent complete remission, in terms of tumor size, as a result of concurrent chemoradiotherapy (cisplatin, etoposid) and the dysesthesia in his legs was alleviated.
Koyama
Yoshiko
Y
Department of Internal Medicine, Fukui Medical University, 23-3, Shimo-Aizuki, Matsuoka-cho, Yoshida-gun, Fukui 910-1193.
Miyashita
Kouichi
K
Anzai
Masaki
M
Kadowaki
Maiko
M
Fujita
Masakuni
M
Mizuno
Shirou
S
Totani
Yoshitaka
Y
Demura
Yoshiki
Y
Ameshima
Shingo
S
Ishizaki
Takeshi
T
Miyamori
Isamu
I
D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D003131:Combined Modality Therapy; D051959:ELAV Proteins; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D020364:Paraneoplastic Polyneuropathy / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D010292:Paresthesia / Q000209:etiology / Q000628:therapy; D016601:RNA-Binding Proteins / Q000276:immunology*; D016896:Treatment Outcome
D001323:Autoantibodies; D014408:Biomarkers, Tumor; D051959:ELAV Proteins; D016601:RNA-Binding Proteins