Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules.
Three members of the S100 family of calcium-binding proteins comprise a new group of proinflammatory molecules released by phagocytes. A novel inflammatory syndrome defined by extraordinarily high expression of S100A8 and S100A9 confirmed recent observations in vitro demonstrating a role of these proteins during recruitment of leukocytes. S100A12 directly activates endothelial cells, mononuclear phagocytes and lymphocytes through interaction with the receptor for advanced glycation end products. Thus, these S100-proteins are attractive targets to modulate inflammation.
Roth
Johannes
J
Institute of Experimental Dermatology, University of Muenster, Von-Esmarch-Str. 58, D-48149 Muenster, Germany.
Vogl
Thomas
T
Sorg
Clemens
C
Sunderkötter
Cord
C
D040501:Calgranulin A / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism*; D010586:Phagocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D011487:Protein Conformation; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism; D009418:S100 Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D015398:Signal Transduction
D040501:Calgranulin A; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D009418:S100 Proteins