title: Does palmitoylation target estrogen receptors to plasma membrane caveolae?
abstract: The human nuclear estrogen receptors (i.e., ERalpha and ERbeta), as other transcriptional factors, regulate cellular processes inducing genomic events. In addition, the binding of 17beta-estradiol to ERs induces different membrane initiating non-genomic signaling. The non-genomic effects of ER are independent of transcriptional activity of the receptor and have been attributed to membrane ERs belonging to a signaling complex localized in caveolae. Here, we postulate that S-acylation of cysteine residue(s) present in the ligand binding domain of ERalpha and ERbeta may play a critical role in the membrane caveolar localization of the receptor and in the formation of the 'steroid signalosome'.
authors.affiliation: Dipartimento di Biologia, Università Roma Tre, Viale Guglielmo Marconi 446, I-00146, Roma, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Acconcia
authors.forename: Alessio
authors.initials: A
authors.lastname: Bocedi
authors.forename: Paolo
authors.initials: P
authors.lastname: Ascenzi
authors.forename: Maria
authors.initials: M
authors.lastname: Marino
mesh_terms: D000215:Acylation; D000595:Amino Acid Sequence; D021941:Caveolae / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment
chemical_list: D020033:Protein Isoforms; D011960:Receptors, Estrogen