[Corticosteroid dependence and resistance in Crohn's disease: prevalence and predictive factors].
The aim of our study was to determine the prevalence of corticosensibility, corticodependency, and corticoresistance in patients with Crohn's disease. Ninety four treatments with corticoids were prescribed to the patients during the follow-up. The rates of corticosensibility, corticodependency, and corticoresistance were 66%, 16%, 18%. Corticodependency and corticoresistance are frequent in Crohn's disease. Corticodependency is more frequent in young patients and when corticoids were previously taken. A high CDAI was the only factor associated with a higher risk of corticoresistance.
Karoui
Sami
S
Service de Gastro-entérologie A, Hôpital la Rabta, Tunis, Tunisie.
Ben Yaghlene
Lamia
L
Fekih
Monia
M
Boubaker
Jalel
J
Filali
Azza
A
D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000494:pharmacology*; D000328:Adult; D003424:Crohn Disease / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
D000305:Adrenal Cortex Hormones
Corticodependance et corticoresistance au cours de la maladie de Crohn: prevalence et facteurs predictifs.