In vitro activity of amphotericin B and itraconazole in combination with flucytosine, sulfadiazine and quinolones against Exophiala spinifera.
The combined effects of antifungal and antibiotic drugs against Exophiala spinifera were evaluated in vitro by the chequer-board method, calculated as a fractional inhibitory concentration (FIC) index. Amphotericin B was combined with flucytosine and ciprofloxacin, whereas itraconazole was combined with ciprofloxacin, levofloxacin, lomefloxacin and sulfadiazine. Synergic effects were observed for the combinations of itraconazole with ciprofloxacin and levofloxacin, and amphotericin B with ciprofloxacin and flucytosine. No antagonism was observed for any combination tested.
Vitale
R G
RG
Department of Medical Microbiology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Afeltra
J
J
de Hoog
G S
GS
Rijs
A J
AJ
Verweij
P E
PE
D000666:Amphotericin B / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D004338:Drug Combinations; D005093:Exophiala / Q000187:drug effects*; D005437:Flucytosine / Q000494:pharmacology*; D017964:Itraconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology*; D013411:Sulfadiazine / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D004338:Drug Combinations; D015363:Quinolones; D013411:Sulfadiazine; D017964:Itraconazole; D000666:Amphotericin B; D005437:Flucytosine