title: Non-supervised spatio-temporal analysis of interictal magnetic spikes: comparison with intracerebral recordings.
abstract: OBJECTIVE
  Our main goal was to evaluate the accuracy of an original non-supervised spatio-temporal magnetoencephalography (MEG) localization method used to characterize interictal spikes generators.
  
  
  METHODS
  MEG and stereotactic intracerebral recordings (stereo-electro-encephalographic exploration, SEEG) data were analyzed independently in 4 patients. MEG localizations were performed with and without anatomical constraints.
  
  
  RESULTS
  We analyzed 1326 interictal spikes recorded using MEG. For each patient, 2-3 typical source patterns were described. These source configurations were compared with SEEG. SEEG findings and MEG spatio-temporal localization results were remarkably coherent in our 4 patients. Most of the MEG patterns were similar to interictal SEEG patterns from a spatio-temporal point of view.
  
  
  CONCLUSIONS
  We were able to evaluate the usefulness of our non-invasive localization method. This approach described correctly the part of the epileptogenic network involved in the generation of interictal events. Our results demonstrate the potential of MEG in the non-invasive spatio-temporal characterization of generators of interictal spikes.
authors.affiliation: UPRES EA Cortex cérébral et Epilepsie, Université de Rennes 1, Rennes, France. denis.schwartz@chups.jussieu.fr
authors.forename: D P
authors.initials: DP
authors.lastname: Schwartz
authors.forename: J M
authors.initials: JM
authors.lastname: Badier
authors.forename: J P
authors.initials: JP
authors.lastname: Vignal
authors.forename: P
authors.initials: P
authors.lastname: Toulouse
authors.forename: J M
authors.initials: JM
authors.lastname: Scarabin
authors.forename: P
authors.initials: P
authors.lastname: Chauvel
mesh_terms: D000293:Adolescent; D000328:Adult; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000175:diagnosis*; D005069:Evaluation Studies as Topic; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008959:Models, Neurological; D013238:Stereotaxic Techniques