Effects of dietary linseed, evening primrose or fish oils on fatty acid and prostaglandin E2 contents in the rat livers and 7,12-dimethylbenz[a]anthracene-induced tumours.
We examined the influence of diets supplemented with fish and vegetable oils on fatty acid and prostaglandin E2 (PGE2) contents in livers of non-7,12-dimethylbenz[a]anthracene (DMBA)- and DMBA-treated rats, and in DMBA-induced tumours. Decreased concentrations of saturated fatty acids and increased unsaturated fatty acid levels were observed in liver phospholipids of rats fed these oils. There was a marked difference in the concentrations of fatty acids found in the tumours and those present in liver lipids. Oleic acid was the main unsaturated fatty acid found in the tumour tissue. Both liver and tumour PGE2 contents were clearly correlated to the diet. The PGE2 concentrations were decreased in livers and tumours of rats fed fish (FO) and linseed oils (LO).
Jelińska
Małgorzata
M
Department of Bromatology, Faculty of Pharmacy, The Medical University of Warsaw, Banacha 1, 02-097, Warsaw, Poland.
Tokarz
Andrzej
A
Oledzka
Regina
R
Czorniuk-Sliwa
Alicja
A
D015127:9,10-Dimethyl-1,2-benzanthracene; D000704:Analysis of Variance; D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D015232:Dinoprostone / Q000032:analysis / Q000096:biosynthesis / Q000378:metabolism*; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism*; D005228:Fatty Acids, Essential / Q000008:administration & dosage; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage; D008041:Linoleic Acids; D008043:Linseed Oil / Q000008:administration & dosage; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000209:etiology / Q000378:metabolism*; D031665:Oenothera biennis; D010713:Phosphatidylcholines / Q000737:chemistry / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000737:chemistry / Q000378:metabolism; D010938:Plant Oils; D051381:Rats; D017207:Rats, Sprague-Dawley; D017965:gamma-Linolenic Acid
D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005228:Fatty Acids, Essential; D005395:Fish Oils; D008041:Linoleic Acids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010938:Plant Oils; C028498:evening primrose oil; D015127:9,10-Dimethyl-1,2-benzanthracene; D017965:gamma-Linolenic Acid; D008043:Linseed Oil; D015232:Dinoprostone