title: Severe palmo-plantar hyperkeratosis in Koebner epidermolysis bullosa simplex.
abstract: A 22-year-old Japanese woman with Koebner epidermolysis bullosa simplex presented with severe palmo-plantar hyperkeratosis. Skin biopsy specimens from the palm revealed hyperkeratosis and acanthosis with blistering in the basal cell layer. An electron microscopic study showed cytolysis of basal cells and clumping of tonofilaments forming thick bundles and perinuclear electron-dense bodies. Hand contractures were released and covered with full thickness autografts or split thickness autografts. The donor site was successfully treated with cultured epidermal autografts.
authors.affiliation: Department of Dermatology, Ehime University School of Medicine, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shirakata
authors.forename: Katsuto
authors.initials: K
authors.lastname: Tamai
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nakaoka
authors.forename: Sho
authors.initials: S
authors.lastname: Tokumaru
authors.forename: Koji
authors.initials: K
authors.lastname: Sayama
authors.forename: Shinji
authors.initials: S
authors.lastname: Murakami
authors.forename: Koji
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000328:Adult; D016110:Epidermolysis Bullosa Simplex / Q000150:complications* / Q000473:pathology; D005260:Female; D006227:Hand Deformities, Acquired / Q000209:etiology / Q000601:surgery; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000473:pathology