Adaptive immune response of Vgamma2Vdelta2 T cells: a new paradigm.
The role of gammadelta T cells in adaptive immunity remains uncertain. Recent studies have demonstrated that a unique subset of gammadelta T cells in primates can mount adaptive immune responses during mycobacterial infections. This Review discusses notable similarities and differences in adaptive immune responses between non-peptide-specific gammadelta T cells and peptide-specific alphabeta T cells, and discusses both the molecular basis for gammadelta T-cell responses and potential functions of these enigmatic cells.
Chen
Zheng W
ZW
Tuberculosis Research Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RE113/RE216, Boston, MA 02115, USA. zchen@caregroup.harvard.edu
Letvin
Norman L
NL
D000818:Animals; D002465:Cell Movement; D019672:Genes, T-Cell Receptor / Q000235:genetics; D006801:Humans; D009163:Mycobacterium bovis / Q000276:immunology; D011323:Primates / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
D016692:Receptors, Antigen, T-Cell, gamma-delta