Effect of social isolation on behavioral parameters and sensitivity of rats to morphine and caffeine.
Social isolation is a stress factor increasing animal anxiety and impairing food-reinforced instrumental learning. Social isolation modulates sensitivity to psychoactive substances: it potentiated the depressive and analgesic effects of morphine, but attenuated the activating and anxiogenic effects of caffeine. These behavioral changes and changes in sensitivity to psychoactive agents can be explained by a well-known phenomenon of activation of the endogenous opioid system during stress.
Sudakov
S K
SK
National Center of Narcology, Ministry of Health of Russian Federation, Moscow. s-sudakov@mtu-net.ru
Medvedeva
O F
OF
Rusakova
I V
IV
Figurina
I B
IB
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002110:Caffeine / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003863:Depression / Q000523:psychology; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D011595:Psychomotor Agitation / Q000523:psychology; D051381:Rats; D012934:Social Isolation / Q000523:psychology
D000701:Analgesics, Opioid; D000697:Central Nervous System Stimulants; D002110:Caffeine; D009020:Morphine