title: Molecular patchwork: Chromosomal recombination between two Helicobacter pylori strains during natural colonization.
abstract: Genetic analysis of two Helicobacter pylori strains isolated from a single gastric biopsy showed evidence of extensive horizontal gene transfer. Several large recombinations were identified in the rdxA gene, which is involved in metronidazole resistance.
authors.affiliation: Department of Medical Microbiology and Infection Control, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. lc.smeets@vumc.nl
authors.forename: Leonard C
authors.initials: LC
authors.lastname: Smeets
authors.forename: Nicolaas L A
authors.initials: NL
authors.lastname: Arents
authors.forename: Anton A
authors.initials: AA
authors.lastname: van Zwet
authors.forename: Christina M J E
authors.initials: CM
authors.lastname: Vandenbroucke-Grauls
authors.forename: Theo
authors.initials: T
authors.lastname: Verboom
authors.forename: Wilbert
authors.initials: W
authors.lastname: Bitter
authors.forename: Johannes G
authors.initials: JG
authors.lastname: Kusters
mesh_terms: D000483:Alleles; D001483:Base Sequence; D002876:Chromosomes, Bacterial; D024881:Drug Resistance, Bacterial; D005753:Gastric Mucosa / Q000382:microbiology*; D016480:Helicobacter pylori / Q000187:drug effects / Q000235:genetics*; D008795:Metronidazole / Q000494:pharmacology; D008969:Molecular Sequence Data; D009601:Nitroreductases / Q000235:genetics; D011995:Recombination, Genetic
chemical_list: D008795:Metronidazole; C029492:aromatic NADH-dependent nitroreductase; D009601:Nitroreductases