Similar levels of nitric oxide in exhaled air in non-asthmatic rhinitis and asthma after bronchial allergen challenge.
BACKGROUND
Nitric oxide in exhaled air (eNO) is elevated in allergic asthma compared with healthy subjects and has been proposed as a marker of bronchial inflammation. However, eNO is elevated to a lesser extent in allergic non-asthmatic rhinitis as well. Considering the distinctive clinical appearances of both allergic diseases, differences in eNO are expected to persist after allergen exposure. The aim of the study was to compare allergen-induced changes in eNO in house dust mite sensitized patients with asthma and patients with perennial rhinitis without asthma symptoms.


METHODS
Bronchial allergen challenge was performed in 52 patients sensitized to house dust mite (Dermatophagoides pteronyssinus), of whom 26 had non-asthmatic rhinitis and 26 had asthma. Levels of eNO were measured before and 1 h, 1 day and 1 week after challenge.


RESULTS
At baseline eNO was significantly lower in non-asthmatic rhinitis compared with asthma (geometric mean eNO (SEM): 121 (1.1) in non-asthmatic rhinitis vs 197 (1.1) nl/min in asthma, P < 0.006). However, the increase in eNO after bronchial allergen challenge in non-asthmatic rhinitis, in particular in those patients with a dual asthmatic response, significantly exceeded the increase in asthma resulting in similar levels of eNO after challenge (geometric mean eNO (SEM) at 24 h postchallenge 204 (1.1) in non-asthmatic rhinitis vs 244 (1.1)nl/min in asthma, P = 0.3).


CONCLUSIONS
The difference in eNO between non-asthmatic rhinitis and asthma at baseline is abolished after allergen exposure due to a significantly greater increase in eNO in non-asthmatic rhinitis.
Lopuhaä
C E
CE
Department of Pulmonology, Academic Medical Center, University of Amsterdam, The Netherlands.
Koopmans
J G
JG
Jansen
H M
HM
van der Zee
J S
JS
D000280:Administration, Inhalation; D000328:Adult; D000485:Allergens; D001249:Asthma / Q000378:metabolism* / Q000503:physiopathology; D001985:Bronchial Provocation Tests / Q000379:methods*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006632:Histamine; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011446:Prospective Studies; D039981:Pyroglyphidae; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism* / Q000503:physiopathology; D013997:Time Factors
D000485:Allergens; D001993:Bronchodilator Agents; D009569:Nitric Oxide; D006632:Histamine