title: Airway ion transport on the first postnatal day in infants delivered vaginally or by elective cesarean section.
abstract: To determine airway ion transport in term infants on the first day of postnatal life, and to test the hypothesis that infants born without labor have reduced sodium absorption, we measured nasal potential difference using a modified perfusion protocol suitable for newborn infants. We examined maximal stable baseline potential difference, the change after perfusion with 10(-4) M amiloride (Deltaamil), and the change after perfusion with a zero-chloride solution (Deltazero Cl-) in infants born after elective cesarean section (n = 21) or normal labor (n = 20). Maximal stable baseline potential difference was not different in the two cohorts (-24.0 mV, range -9 to -64 mV versus -25.5 mV, range -6 to -44 mV). The majority of infants in both cohorts showed a substantial fall in potential difference after amiloride perfusion, and there was little capacity for chloride secretion. These results demonstrate a fluid absorptive pattern in the airways on the first postnatal day. In these well infants, the ion transport phenotype was not dependent on the presence or absence of labor.
authors.affiliation: Liverpool Women's Hospital, Neonatal Unit, University of Liverpool, Liverpool, UK. erol.gaillard@lwh-tr.nwest.nhs.uk
authors.forename: Erol A
authors.initials: EA
authors.lastname: Gaillard
authors.forename: Nigel J
authors.initials: NJ
authors.lastname: Shaw
authors.forename: Helen L
authors.initials: HL
authors.lastname: Wallace
authors.forename: Nimish V
authors.initials: NV
authors.lastname: Subhedar
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Southern
mesh_terms: D002585:Cesarean Section; D002712:Chlorides / Q000378:metabolism*; D053503:Epithelial Sodium Channels; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009297:Nasal Mucosa / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D015222:Sodium Channels / Q000378:metabolism; D014621:Vagina
chemical_list: D002712:Chlorides; D053503:Epithelial Sodium Channels; D015222:Sodium Channels; D012964:Sodium