title: [Safety of the use of Celsior in kidney-pancreas transplantation].
abstract: The objective of this prospective observation study was to evaluate the safety of use of Celsior extracellular solution, initially designed for cardiac preservation, in kidney-pancreas transplantation.
  
  
  METHODS
  From August 1999 to July 2000, 140 kidneys and 9 pancreases were harvested from 71 cadaveric donors with a mean age of 34 +/- 11 years, washed and preserved until transplantation with Celsior. One hundred and thirty one isolated renal transplantations and 9 combined kidney-pancreas transplantations were performed. The mean age of isolated kidney recipients and kidney-pancreas recipients was 42 +/- 13 years (range: 4-71 years) and 39 +/- 7 years (range: 31-52 years), respectively. The mean cold ischaemia time was 21 +/- 8 hours (range: 4-45) for kidneys and 11.43 +/- 2.9 hours (range: 6-15 hours) for pancreases.
  
  
  RESULTS
  No cardiac or haemodynamic incidents were observed during organ revascularization. No electrolyte or haematological abnormalities were observed postoperatively. The one-year graft survival rate was 96% (range: 93%-99%) for kidneys and 89% (range: 55%-100%) for pancreases. Patient survival was 100%. Return of renal transplant function was delayed in 14% (8-20%) of patients, requiring dialysis during the first week. Mean serum creatinine at 3 months and at 1 year was 123 +/- 41 mumol/l and 118.5 +/- 33.8 mumol/l, respectively. One pancreas and one kidney were lost due to venous thrombosis on D2 and D4. Two patients in the kidney-pancreas group were reoperated.
authors.affiliation: Clinique Urologique, CHU Hôtel-Dieu, Nantes, France. gkaram@chu-nantes.fr
authors.forename: Georges
authors.initials: G
authors.lastname: Karam
mesh_terms: D002102:Cadaver; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D005978:Glutathione; D006639:Histidine; D006801:Humans; D007668:Kidney; D016030:Kidney Transplantation / Q000379:methods*; D008353:Mannitol; D019188:Organ Preservation Solutions; D010179:Pancreas; D016035:Pancreas Transplantation / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014019:Tissue Donors; D020858:Tissue and Organ Harvesting
chemical_list: C088453:Celsior; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D019188:Organ Preservation Solutions; D008353:Mannitol; D006639:Histidine; D005978:Glutathione
vernacular_title: Sécurité d'utilisation de Celsior en transplantation rénale et pancréatique.