Sphingolipids from Bombycis Corpus 101A and their neurotrophic effects.
Three new (2-4) and one known (1) sphingolipid were identified in the MeOH extract of Bombycis Corpus 101A. Their structures were elucidated as (4E,2S,3R)-2-N-octadecanoyl-4-tetradecasphingenine (1), (4E,6E,2S,3R)-2-N-eicosanoyl-4,6-tetradecasphingadienine (2), (4E,2S,3R)-2-N-eicosanoyl-4-tetradecasphingenine (3), and (4E,6E,2S,3R)-2-N-docosanoyl-4,6-tetradecasphingadienine (4) on the basis of spectroscopic data. Their neurotrophic effects were evaluated by examining PC12 cell neurite outgrowth.
Kwon
Hak Cheol
HC
College of Pharmacy, Sung Kyun Kwan University, Suwon 440-746, Republic of Korea.
Lee
Kang Choon
KC
Cho
Ock Ryun
OR
Jung
I Yeon
IY
Cho
Sae Yun
SY
Kim
Sun Yeou
SY
Lee
Kang Ro
KR
D000818:Animals; D012831:Bombyx / Q000737:chemistry*; D007723:Korea; D007814:Larva / Q000737:chemistry; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells / Q000187:drug effects; D051381:Rats; D013107:Sphingolipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
D009414:Nerve Growth Factors; D013107:Sphingolipids