title: [Corticosteroid dependence and resistance in Crohn's disease: prevalence and predictive factors].
abstract: The aim of our study was to determine the prevalence of corticosensibility, corticodependency, and corticoresistance in patients with Crohn's disease. Ninety four treatments with corticoids were prescribed to the patients during the follow-up. The rates of corticosensibility, corticodependency, and corticoresistance were 66%, 16%, 18%. Corticodependency and corticoresistance are frequent in Crohn's disease. Corticodependency is more frequent in young patients and when corticoids were previously taken. A high CDAI was the only factor associated with a higher risk of corticoresistance.
authors.affiliation: Service de Gastro-entérologie A, Hôpital la Rabta, Tunis, Tunisie.
authors.forename: Sami
authors.initials: S
authors.lastname: Karoui
authors.forename: Lamia
authors.initials: L
authors.lastname: Ben Yaghlene
authors.forename: Monia
authors.initials: M
authors.lastname: Fekih
authors.forename: Jalel
authors.initials: J
authors.lastname: Boubaker
authors.forename: Azza
authors.initials: A
authors.lastname: Filali
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000494:pharmacology*; D000328:Adult; D003424:Crohn Disease / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000305:Adrenal Cortex Hormones
vernacular_title: Corticodependance et corticoresistance au cours de la maladie de Crohn: prevalence et facteurs predictifs.