title: YM-266183 and YM-266184, novel thiopeptide antibiotics produced by Bacillus cereus isolated from a marine sponge II. Structure elucidation.
abstract: YM-266183 and YM-266184 are new antibacterial substances that have activity against drug-resistant bacteria produced by Bacillus cereus QN03323. These structures were elucidated by MS and NMR spectral analysis. YM-266183 and YM-266184 are the cyclic thiopeptides containing thiazole and pyridine moieties, and several unusual amino acids.
authors.affiliation: Analysis & Metabolism Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 21 Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan. nagai@yamanouchi.co.jp
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Suzumura
authors.forename: Takako
authors.initials: T
authors.lastname: Yokoi
authors.forename: Masashi
authors.initials: M
authors.lastname: Funatsu
authors.forename: Koji
authors.initials: K
authors.lastname: Nagai
authors.forename: Koichi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Huiping
authors.initials: H
authors.lastname: Zhang
authors.forename: Kenichi
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001409:Bacillus cereus / Q000378:metabolism*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry*; D011161:Porifera / Q000382:microbiology; D011725:Pyridines / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; D010456:Peptides, Cyclic; D011725:Pyridines; D013844:Thiazoles; C474182:YM 266183; C474183:YM 266184