Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata.
Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C(24) acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC(50) of 15.0 microg/mL.
Fujita
Masaki
M
Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Nakao
Yoichi
Y
Matsunaga
Shigeki
S
van Soest
Rob W M
RW
Itoh
Yoshifumi
Y
Seiki
Motoharu
M
Fusetani
Nobuhiro
N
D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000480:Alkynes; D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007564:Japan; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D011161:Porifera / Q000737:chemistry*; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
D000480:Alkynes; D005231:Fatty Acids, Unsaturated; D011480:Protease Inhibitors; C477589:callysponginol sulfate A; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases; D000114:Acetylene