Epilepsy, atherosclerosis, myocardial infarction, and carbamazepine.
Epileptic patients receiving medications such as phenytoin or phenobarbital have been noted to have an exceedingly low incidence of myocardial infarction, but children treated with carbamazepine have shown alteration of their serum lipid profile that could predispose them to atherosclerosis. This report seems to corroborate this point and describes the findings in an 11-year-old boy who died following a major seizure, rhabdomyolysis, and renal failure. The autopsy demonstrated that he had marked coronary atherosclerosis and myocardial infarction. The child had been treated with carbamazepine for more than 10 years.
de Chadarévian
Jean-Pierre
JP
Department of Pathology and Laboratory Medicine, Drexel University College of Medicine, St. Christopher's Hospital for Children, Philadelphia, Pennsylvania 19134, USA. JD37@drexel.edu
Legido
Agustin
A
Miles
Daniel K
DK
Katsetos
Christos D
CD
D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001344:Autopsy; D002220:Carbamazepine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003324:Coronary Artery Disease / Q000139:chemically induced*; D004827:Epilepsy / Q000188:drug therapy*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced*; D051437:Renal Insufficiency; D012206:Rhabdomyolysis / Q000473:pathology; D013997:Time Factors
D000927:Anticonvulsants; D002220:Carbamazepine