Enzymes with extra talents: moonlighting functions and catalytic promiscuity.
Recent studies of moonlighting functions and catalytic promiscuity provide insights into the structural and mechanistic bases of these phenomena. Moonlighting proteins that are highlighted include gephyrin, the Neurospora crassa tyrosyl tRNA synthetase, phosphoglucose isomerase, and cytochrome c. New insights into catalytic promiscuity are provided by studies of aminoglycoside kinase (3') type IIIa, tetrachlorohydroquinone dehalogenase, and aldolase antibody 38C2.
Copley
Shelley D
SD
Department of Molecular, Cellular, and Developmental Biology and Cooperative Institute for Research in Environmental Sciences, University of Colorado at Boulder Campus, Box 216, Boulder, CO 80309-0216, USA. copley@cires.colorado.edu
D000818:Animals; D002384:Catalysis; D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D013379:Substrate Specificity
D004798:Enzymes