title: An assessment of different filter systems for extracorporeal elimination of bivalirudin: an in vitro study.
abstract: Bivalirudin is a new, direct thrombin inhibitor. We investigated the extracorporeal elimination rate of different hemofilters and one plasmapheresis filter for bivalirudin. Our data show that bivalirudin can be effectively eliminated via hemofiltration and plasmapheresis, although there were significant differences in the elimination rates among the filter systems investigated.
authors.affiliation: Departments for *Anesthesia and †Thoracic and Cardiovascular Surgery, Deutsches Herzzentrum Berlin, Berlin, Germany; ‡Department of Cardiology, Flinders Medical Center, South Australia, Australia; and §Department of Cardiothoracic Anesthesia, Virginia Commonwealth University, Richmond, Virginia.
authors.forename: Andreas
authors.initials: A
authors.lastname: Koster
authors.forename: Derek
authors.initials: D
authors.lastname: Chew
authors.forename: Marcus
authors.initials: M
authors.lastname: Gründel
authors.forename: Harald
authors.initials: H
authors.lastname: Hausmann
authors.forename: Onnen
authors.initials: O
authors.lastname: Grauhan
authors.forename: Herman
authors.initials: H
authors.lastname: Kuppe
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Spiess
mesh_terms: D000925:Anticoagulants / Q000302:isolation & purification*; D001774:Blood Chemical Analysis; D002315:Cardiopulmonary Bypass; D006400:Hematocrit; D006440:Hemofiltration / Q000379:methods*; D006629:Hirudins / Q000031:analogs & derivatives* / Q000302:isolation & purification*; D006801:Humans; D066298:In Vitro Techniques; D009997:Osmotic Pressure; D010446:Peptide Fragments / Q000302:isolation & purification*; D011994:Recombinant Proteins / Q000302:isolation & purification*; D006435:Renal Dialysis; D014462:Ultrafiltration
chemical_list: D000925:Anticoagulants; D006629:Hirudins; D010446:Peptide Fragments; D011994:Recombinant Proteins; C074619:bivalirudin