title: Fulvestrant antiestrogen for treatment of breast cancer.
abstract: Fulvestrant injection (Faslodex, AstraZeneca Pharmaceuticals LP, Wilmington, DE) is a novel estrogen receptor antagonist with no known agonist effects. Indicated for the palliative treatment of postmenopausal, endocrine-response, advanced breast cancer, the drug is well tolerated, and its most common side effect is mild gastrointestinal symptoms. Fulvestrant is administered as a once-a-month intramuscular injection in an outpatient setting. Its unique mechanism of action represents a new way to palliate breast cancer and may offer new options for women with advanced, endocrine-responsive disease.
authors.affiliation: christiemh@sbcglobal.net
authors.forename: Christie M
authors.initials: CM
authors.lastname: Hancock
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004958:Estradiol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D020847:Estrogen Receptor Modulators / Q000627:therapeutic use; D005260:Female; D000077267:Fulvestrant; D006801:Humans
chemical_list: D018931:Antineoplastic Agents, Hormonal; D004965:Estrogen Antagonists; D020847:Estrogen Receptor Modulators; D000077267:Fulvestrant; D004958:Estradiol