Implantable microelectrodes with new electro-conductive materials for recording sympathetic neural discharge.
We have developed two new types of bipolar cuff microelectrodes (volume size, 2-3 mm(3)) using electro-conductive rubber or water-absorbent polymer, either of which can be applied to measure sympathetic nerve activity in small animals. A renal nerve bundle of an anesthetized rat was inserted into the center hole of the electrode (diameter, 0.15 mm) through a slit and had good contact with the electrodes. Renal sympathetic nerve activity, which was verified by sympathetic ganglionic blockade, could be recorded using either type of implantable cuff electrode.
Matsukawa
Kanji
K
Department of Physiology, Institute of Health Sciences, Hiroshima University Faculty of Medicine, Kasumi 1-2-3, Minami-ku, Hiroshima, 734-8551 Japan. matsuk@hiroshima-u.ac.jp
Komine
Hidehiko
H
Tsuchimochi
Hirotsugu
H
Murata
Jun
J
Yonezawa
Yoshiharu
Y
Kondo
Kazuhiko
K
Seki
Yasuo
Y
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004567:Electrodes, Implanted; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D007668:Kidney / Q000294:innervation* / Q000502:physiology*; D008839:Microelectrodes; D010525:Peripheral Nerves / Q000502:physiology*; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology*