title: BRCA proteins and DNA damage checkpoints.
abstract: BRCA1 and BRCA2 are frequently mutated in breast cancer patients, responsible for the majority cases of familial breast cancer. Through genetic and biochemical analysis, the function of BRCA1 and BRCA2 is emerging. This review examines recent progresses in understanding the roles of BRCA proteins in DNA damage checkpoint control and how they are regulated in response to DNA damage
authors.affiliation: Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Zhenkun
authors.initials: Z
authors.lastname: Lou
authors.forename: Junjie
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D002453:Cell Cycle / Q000502:physiology*; D004249:DNA Damage / Q000235:genetics*; D006801:Humans; D010766:Phosphorylation
chemical_list: D019313:BRCA1 Protein; D024682:BRCA2 Protein