Diversity of mechanism-based pharmacodynamic models.
Pharmacodynamics is the study of the time course of pharmacological effects of drugs. The field of pharmacodynamic modeling has made many advances, due in part to the relatively recent development of basic and extended mechanism-based models. The purpose of this article is to describe the classic as well as contemporary approaches, with an emphasis on pertinent equations and salient model features. In addition, current methods of integrating various system complexities into these models are discussed. Future pharmacodynamic models will most likely reflect an assembly of the basic components outlined in this review.
Mager
Donald E
DE
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
Wyska
Elzbieta
E
Jusko
William J
WJ
D002455:Cell Division / Q000187:drug effects; D004361:Drug Tolerance; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D010600:Pharmacology; D011955:Receptors, Drug / Q000378:metabolism; D015398:Signal Transduction
D011955:Receptors, Drug