title: Dynamics of viral load rebound in plasma and semen after stopping effective antiretroviral therapy.
abstract: A rebound in the plasma and seminal viral load was detected in 12 patients after the interruption of effective highly active antiretroviral therapy. The viral rebound was generally higher in plasma, although the highest level observed during interruption was higher in semen in two patients. The reintroduction of therapy was followed by an overall decrease in HIV-RNA in plasma and semen. One to 2 months after restarting treatment, four out of seven patients showed undetectable HIV-RNA in semen.
authors.affiliation: National Institute for Infectious Diseases L. Spallanzani, Rome, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Liuzzi
authors.forename: Gianpiero
authors.initials: G
authors.lastname: D'Offizi
authors.forename: Simone
authors.initials: S
authors.lastname: Topino
authors.forename: Mauro
authors.initials: M
authors.lastname: Zaccarelli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Amendola
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Capobianchi
authors.forename: Carlo Federico
authors.initials: CF
authors.lastname: Perno
authors.forename: Pasquale
authors.initials: P
authors.lastname: Narciso
authors.forename: Andrea
authors.initials: A
authors.lastname: Antinori
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis; D012661:Semen / Q000821:virology*; D013997:Time Factors; D016312:Treatment Refusal; D019562:Viral Load; D014766:Viremia / Q000188:drug therapy
chemical_list: D012367:RNA, Viral