Acute P. falciparum malaria induces a loss of CD28- T IFN-gamma producing cells.
P. falciparum malaria is associated with increased activation among peripheral lymphocytes. In the present study, we investigated markers of susceptibility to apoptosis and expression of IFN-gamma and IL-4 by CD28-and CD28+T cells in West African children with acute P. falciparum malaria. The study showed increased susceptibility to apoptosis and cytokine production among T lymphocytes during acute malaria but also that T cells, in particular IFN-gamma producing CD28-T cells, were substantially reduced. These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria.
Kemp
Kåre
K
Centre for Medical Parasitology at Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet) and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark. kkcmp@hotmail.com
Akanmori
Bartholomew D
BD
Kurtzhals
Jørgen A L
JA
Adabayeri
Victoria
V
Goka
Bamenla Q
BQ
Hviid
Lars
L
D000208:Acute Disease; D000818:Animals; D017209:Apoptosis; D018106:CD28 Antigens / Q000032:analysis*; D019254:Genes, bcl-2; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000032:analysis; D016778:Malaria, Falciparum / Q000276:immunology*; D010963:Plasmodium falciparum / Q000472:pathogenicity; D016176:T-Lymphocyte Subsets / Q000145:classification; D013601:T-Lymphocytes / Q000276:immunology*; D019014:fas Receptor / Q000032:analysis
D018106:CD28 Antigens; D019014:fas Receptor; D015847:Interleukin-4; D007371:Interferon-gamma