title: Ganglioside patterns mature at different rates in functionally related subregions of the rat pons.
abstract: Gangliosides are known to be developmentally regulated and regionally variable, but these variations have not been shown to occur among precisely defined nuclei of the brain in relation to either aging or function. We have sought to correlate changes in ganglioside distribution with age-related changes in highly specific brain regions known to control a common function, the regulation of rapid eye movement sleep architecture. Gangliosides were extracted and quantified from micropunched regions of the locus coeruleus, dorsal raphe, laterodorsal tegmentum, pedunculopontine tegmentum and the general region of the pons containing these nuclei in young adult (3 months), adult (12 months), and aged (24 months) rats. The ganglioside distribution patterns were generally characteristic of the pons as a whole, but showed a high level of differentiation in time course at specific anatomical sites.
authors.affiliation: Departmentof Biological Sciences, University of Texas at El Paso, El Paso, Tex 79968, USA. dbyers@utep.edu
authors.forename: Donna M
authors.initials: DM
authors.lastname: Byers
authors.forename: Louis N
authors.initials: LN
authors.lastname: Irwin
authors.forename: Rafael
authors.initials: R
authors.lastname: Cabeza
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001923:Brain Chemistry; D005732:Gangliosides / Q000032:analysis / Q000378:metabolism*; D008297:Male; D011149:Pons / Q000737:chemistry / Q000254:growth & development*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005732:Gangliosides