title: [Paraneoplastic neurologic syndrome and small-cell lung cancer in a patient positive for anti-Hu antigen].
abstract: We encountered a case of small-cell lung cancer with paraneoplastic neurologic syndrome in a 68-year old man. Progressive dysesthesia had developed in his hands and legs over a period of 4 months. Chest radiography and chest CT scanning on admission showed a mass in the hilum of the left lung. Anti-Hu antibody was found in his serum and the subsequent histopathological diagnosis by TBLB was small cell lung cancer. The patient underwent complete remission, in terms of tumor size, as a result of concurrent chemoradiotherapy (cisplatin, etoposid) and the dysesthesia in his legs was alleviated.
authors.affiliation: Department of Internal Medicine, Fukui Medical University, 23-3, Shimo-Aizuki, Matsuoka-cho, Yoshida-gun, Fukui 910-1193.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Koyama
authors.forename: Kouichi
authors.initials: K
authors.lastname: Miyashita
authors.forename: Masaki
authors.initials: M
authors.lastname: Anzai
authors.forename: Maiko
authors.initials: M
authors.lastname: Kadowaki
authors.forename: Masakuni
authors.initials: M
authors.lastname: Fujita
authors.forename: Shirou
authors.initials: S
authors.lastname: Mizuno
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Totani
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Demura
authors.forename: Shingo
authors.initials: S
authors.lastname: Ameshima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishizaki
authors.forename: Isamu
authors.initials: I
authors.lastname: Miyamori
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D003131:Combined Modality Therapy; D051959:ELAV Proteins; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D020364:Paraneoplastic Polyneuropathy / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy; D010292:Paresthesia / Q000209:etiology / Q000628:therapy; D016601:RNA-Binding Proteins / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D014408:Biomarkers, Tumor; D051959:ELAV Proteins; D016601:RNA-Binding Proteins