title: Plasmodium chabaudi chabaudi AS: modification of acute infection in CBA/Ca mice as a result of pre-treatment with erythrocyte band 3 in adjuvant.
abstract: In this paper, in vivo data are presented that suggest a role for host recognition of erythrocyte band 3 in the control of malaria parasitaemia. The course of Plasmodium chabaudi chabaudi AS acute infection in CBA/Ca mice was suppressed or enhanced as a result of treatment on two occasions with enriched preparations of normal erythrocyte band 3 in adjuvant. Co-treatment with band 3 and a recombinant polypeptide encoding the C-terminal region of the P. c. chabaudi AS merozoite surface protein 1, which on its own had no clear effect on parasitaemia, appeared to modulate band 3-induced inhibition. Despite several-fold reductions in ascending parasitaemias in some band 3-immunized groups, there was a lack of obvious or unexpected anaemia prior to, or during infection, indicating a degree of specificity in the parasitaemia modifying response for infected rather than uninfected erythrocytes. These findings support a role for modified host recognition of erythrocyte band 3 in the partial immunity that transcends phenotypic and genotypic antigenic variation by malaria parasites.
authors.affiliation: Department of Parasitology, National Institute for Medical Research, NW7 1AA, London, UK.
authors.forename: Kieran P
authors.initials: KP
authors.lastname: O'Dea
authors.forename: Paul G
authors.initials: PG
authors.lastname: McKean
authors.forename: K
authors.initials: K
authors.lastname: Neil Brown
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D001457:Anion Exchange Protein 1, Erythrocyte / Q000276:immunology* / Q000302:isolation & purification / Q000627:therapeutic use; D002352:Carrier Proteins / Q000008:administration & dosage / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D008288:Malaria / Q000276:immunology / Q000517:prevention & control*; D008297:Male; D058619:Maltose-Binding Proteins; D020066:Merozoite Surface Protein 1 / Q000008:administration & dosage / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D018512:Parasitemia / Q000276:immunology / Q000517:prevention & control*; D016788:Plasmodium chabaudi / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D001457:Anion Exchange Protein 1, Erythrocyte; D002352:Carrier Proteins; D058619:Maltose-Binding Proteins; D020066:Merozoite Surface Protein 1