title: Renal toxicity in rats after oral administration of mercury-contaminated boiled whale livers marketed for human consumption.
abstract: Some people living in Japan have traditionally eaten the internal organs of small cetaceans (toothed whales and dolphins), and a mixed package of boiled liver, kidney, lung, and so on is still marketed for human consumption. Recently, we reported that these organs are highly contaminated with mercury. In this study, we investigated the absorption, distribution, excretion, and biochemical parameters in serum and urine after a single oral administration of boiled whale liver containing 1980 microg/g of total mercury and 23.5 microg/g of methyl mercury to rats (0.2 g boiled liver/100 g rat). The single administration of the boiled liver resulted in marked increases of the mercury concentration in the rat kidney, urinary volume, and the urinary excretion of N-acetyl-beta-D-glucosanidase, albumin, and sodium, suggesting the renal toxicity caused by inorganic mercury. Furthermore, the administration increased lactate dehydrogenase activity and creatinine, potassium, and phosphorus concentrations in serum. About 95% of total mercury dose was excreted in feces and less than 0.05% was excreted in the urine. Thus, the absorption rate of mercury from the boiled whale liver appears to be about 5% or slightly higher. These data indicate that the human consumption of boiled whale liver may cause acute intoxication by the contaminated inorganic mercury.
authors.affiliation: Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari-Tobetsu, Hokkaido 061-0293, Japan. endotty@hoku-iryo-u.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Endo
authors.forename: Koichi
authors.initials: K
authors.lastname: Haraguchi
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Sakata
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005243:Feces / Q000737:chemistry; D020387:Food Chain; D005511:Food Handling; D007668:Kidney / Q000737:chemistry* / Q000187:drug effects / Q000503:physiopathology; D008099:Liver / Q000737:chemistry*; D008297:Male; D008628:Mercury / Q000032:analysis / Q000633:toxicity* / Q000652:urine; D008630:Mercury Poisoning / Q000503:physiopathology* / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D016482:Urinalysis; D014907:Whales / Q000378:metabolism*
chemical_list: D008628:Mercury