title: [Malignant transformation of epidermoid cyst].
abstract: The paper presents a rare case of malignant transformation of an epidermoid cyst to the keratinizing type of squamous cell carcinoma. In a 47-year-old female patient with severe visual disturbances, MRI scans revealed a large supracellular tumor spreading to the third ventricle and medial portions of temporal lobes. The tumor was removed. A histological study of its biopsy specimen showed signs of both a benign process (epidermoid cysts) and its malignant epidermoid degeneration to the keratinizing type of squamous cell carcinoma. After 12-month combined therapy there was a continuous tumor growth with a significant dissemination within the base of the skull. The pathogenesis of epidermoid cysts, possible causes of malignant transformation, modalities of treatment and prognosis are briefly discussed.
authors.forename: B A
authors.initials: BA
authors.lastname: Kadashev
authors.forename: A N
authors.initials: AN
authors.lastname: Shkarubo
authors.forename: A G
authors.initials: AG
authors.lastname: Korshunov
authors.forename: N A
authors.initials: NA
authors.lastname: Murusidze
authors.forename: S V
authors.initials: SV
authors.lastname: Taniashin
mesh_terms: D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*; D002471:Cell Transformation, Neoplastic; D004814:Epidermal Cyst / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009765:Obesity / Q000209:etiology
vernacular_title: Zlokachestvennaia transformatsiia épidermoidnoĭ kisty.