title: [Migrating subcutaneous swellings due to dirofilariasis after a visit to the South of France].
abstract: In two women, aged 59 and 31 years, who suffered from an itching cutaneous nodule, subcutaneous dirofilariasis was diagnosed. The disease is characterised by recurrent migrating subcutaneous nodules and swellings. Both patients recently visited the South of France. Laboratory examination revealed a moderate eosinophilia. In both patients, filaria antibodies were demonstrated during the course of the disease and a nodule was eventually resected. Parasitological examination revealed Dirofilaria repens. After this the swellings did not recur. Dirofilariasis is a zoonosis common in dogs and cats, and is transmitted by mosquitoes. In humans, the most common clinical manifestation is a migrating subcutaneous nodule in the case of D. repens, and a pulmonary infiltrate (coin lesion on radiographs) in the case of Dirofilaria immitis. Filarial serology is often positive. The diagnosis is confirmed by parasitological examination of the excised nodule. Dirofilariasis is usually innocuous; it disappears after the worm has died but can cause patients to worry.
authors.affiliation: Afd. Interne Geneeskunde, onderafd. Infectieziekten, Tropische Geneeskunde en Aids, Academisch Medisch Centrum/Universiteit van Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam. p.j.devries@amc.uva.nl
authors.forename: P J
authors.initials: PJ
authors.lastname: de Vries
authors.forename: L G
authors.initials: LG
authors.lastname: Visser
authors.forename: H C M
authors.initials: HC
authors.lastname: Vetter
authors.forename: H P
authors.initials: HP
authors.lastname: Muller
authors.forename: A M
authors.initials: AM
authors.lastname: Polderman
mesh_terms: D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D002415:Cats; D004182:Dirofilaria / Q000276:immunology / Q000302:isolation & purification; D004184:Dirofilariasis / Q000175:diagnosis* / Q000473:pathology / Q000635:transmission; D004285:Dogs; D005260:Female; D006801:Humans; D008875:Middle Aged; D012876:Skin Diseases, Parasitic / Q000175:diagnosis* / Q000473:pathology; D014195:Travel; D015047:Zoonoses / Q000635:transmission
chemical_list: D000909:Antibodies, Helminth
vernacular_title: Migrerende subcutane zwellingen door dirofilariasis na een bezoek aan Zuid-Frankrijk.