Endocrine abnormalities in patients with central serous chorioretinopathy.
OBJECTIVE
To investigate and to identify endocrine and metabolic abnormalities in patients with central serous chorioretinopathy (CSCR).


METHODS
Observational case series.


METHODS
Twenty-four patients with CSCR.


METHODS
Serum and urinary catecholamines, glucocorticoids, mineralocorticoids, serum testosterone, and thyroid-stimulating hormone (TSH) function were evaluated prospectively.


RESULTS
Fifty percent (12 of 24) of patients with active acute CSCR showed elevated 24-hour urine cortisol or tetrahydroaldosterone levels. Serum aldosterone levels were low in 7 of 24 (29.1%) patients. Single morning plasma catecholamine levels were elevated in 7 of 24 patients, although 24-hour urine metanephrines (catecholamine breakdown products) were normal. Serum testosterone and TSH levels were normal in nearly all (23 of 24) patients.


CONCLUSIONS
Many patients with acute CSCR have elevated 24-hour urine corticosteroids, which may contribute to the pathogenesis of the disorder. Endogenous mineralocorticoid dysfunction is a newly described feature of CSCR.
Haimovici
Robert
R
Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA.
Rumelt
Shimon
S
Melby
James
J
D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000097:blood / Q000652:urine; D000328:Adult; D002395:Catecholamines / Q000097:blood; D015862:Choroid Diseases / Q000097:blood / Q000150:complications* / Q000652:urine; D004700:Endocrine System Diseases / Q000097:blood / Q000150:complications* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012164:Retinal Diseases / Q000097:blood / Q000150:complications* / Q000652:urine; D013739:Testosterone / Q000097:blood; D013972:Thyrotropin / Q000097:blood
D000305:Adrenal Cortex Hormones; D002395:Catecholamines; D013739:Testosterone; D013972:Thyrotropin