title: Further study on S-nitrosation by nitrite.
abstract: At neutral pH, S-nitrosoglutathione was formed by the reaction of reduced glutathione and sodium nitrite. The degradation of S-nitrosoglutathione, presumably by transnitrosation/denitrosation, was catalyzed by L-cysteine, or CoA-SH. Additionally, from the crude extract of rat brain, one protein with a large molecular mass was nitrosolated with nitrite, and was split into duplet peptides noted in Western blot. Furthermore, the incubation of nitrite with IgG may generate the intermediates of active nitrogen/oxygen species and lead to significant production of gas bubbles.
authors.affiliation: Division of Science and Mathematics, Bethune-Cookman College, Daytona Beach, Florida 32114, USA. kuow@cookman.edu
authors.forename: Wu-Nan
authors.initials: WN
authors.lastname: Kuo
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Kocis
authors.forename: Marvin J
authors.initials: MJ
authors.lastname: Robinson
authors.forename: Janna
authors.initials: J
authors.lastname: Nibbs
authors.forename: Ram
authors.initials: R
authors.lastname: Nayar
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology; D001923:Brain Chemistry; D003593:Cytoplasm / Q000737:chemistry; D009573:Nitrites / Q000737:chemistry*; D015538:Nitrosation; D051381:Rats
chemical_list: D009573:Nitrites