Evaluation of the genes for the adrenergic receptors alpha 2A and alpha 1C and Gilles de la Tourette Syndrome.
Gilles de la Tourette Syndrome (GTS) has long been known to be familial, and evidence from twin studies indicates that it has a substantial genetic component. Our genome scan of sibling pair families with GTS found evidence suggestive of linkage to several chromosomal locations. On the basis of these findings, we have begun to study additional markers in these regions, with some of the markers located in candidate genes. Two candidate genes stand out in these regions: the adrenergic receptor alpha 1C(1A) (ADRA1C) located on chromosome 8p and the adrenergic receptor alpha 2A (ADRA2A) located on chromosome 10q. The adrenergic system has been suggested to play a role in GTS based on the reduction of symptoms with the adrenergic receptor agonists, clonidine and guanfacine. We examined the inheritance of polymorphisms in the ADRA2A and ADRA1C genes in 113 nuclear families identified through a GTS proband. We found no significant evidence for linkage using the transmission disequilibrium test for these two genes. Based on our families, we conclude that these genes are not major genetic factors contributing to the susceptibility to GTS.
Xu
Chun
C
Department of Psychiatry, The Toronto Western Hospital, Toronto, Ontario, Canada.
Ozbay
Fatih
F
Wigg
Karen
K
Shulman
Rayzie
R
Tahir
Eda
E
Yazgan
Yanki
Y
Sandor
Paul
P
Barr
Cathy L
CL
D005192:Family Health; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D040582:Inheritance Patterns; D015810:Linkage Disequilibrium; D018340:Receptors, Adrenergic, alpha-1 / Q000235:genetics*; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D005879:Tourette Syndrome / Q000235:genetics*; D014421:Turkey
C547768:ADRA2A protein, human; D018340:Receptors, Adrenergic, alpha-1; D018341:Receptors, Adrenergic, alpha-2