title: New acetylenic acids from a sponge of the genus Stelletta.
abstract: Three new acetylenic metabolites (1-3) were isolated from the sponge Stelletta sp. collected from Gagu-Do, Korea. On the basis of the results of combined spectroscopic analyses, the structures of these compounds were determined to be an acetylenic acid, its 2-methoxy analogue, and corresponding anhydride, respectively. The new compounds exhibited weak cytotoxicity against a human leukemia cell-line (K562).
authors.affiliation: Marine Natural Products Laboratory, Korea Ocean Research & Development Institute, Ansan P.O. Box 29, Seoul, 425-600, Korea.
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Jung-Rae
authors.initials: JR
authors.lastname: Rho
authors.forename: Chung J
authors.initials: CJ
authors.lastname: Sim
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
mesh_terms: D000480:Alkynes; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007723:Korea; D007938:Leukemia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000480:Alkynes; D000970:Antineoplastic Agents; D005231:Fatty Acids, Unsaturated; C031203:2-hexadecynoic acid