title: [Selenoproteins in rat brain].
abstract: Male Wistar rats fed with diets containing eight different levels of selenium(Se). Six rats in each group were killed after 20 weeks to obtain brains. The other 105 rats in the Se depleted group were then divided into four groups randomly and fed with diets containing four different levels of Se. The rats in these four groups were then killed at different time points to observe the kinetic change of selenoproteins. The lowest dietary Se required for reaching the plateau of the activities of cellular glutathione peroxidase (cGPX), phospholipid hydroperoxide glutathione peroxidase (PHGPX) and type II deiodinase (ID II) were 0.05, 0.03 and 0.01 mg/kg respectively. The lowest dietary Se required for reaching normal expression of selenoprotein P and selenoprotein W were 0.01 and 0.05 mg/kg respectively. While the rats were restored Se from diets supplemented with Se, the expression of selenoprotein P and type II deiodinase were in preference to PHGPX and cGPX, and the later two parameters were in preference to selenoprotein W. The results suggested that the function of selenoprotein P and ID II in brain were more important than the other three selenoproteins.
authors.affiliation: Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China.
authors.forename: X
authors.initials: X
authors.lastname: Yang
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Tian
authors.forename: W
authors.initials: W
authors.lastname: Mu
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D019587:Dietary Supplements; D005979:Glutathione Peroxidase / Q000378:metabolism*; D007453:Iodide Peroxidase / Q000378:metabolism; D008297:Male; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D011506:Proteins / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000008:administration & dosage*; D051149:Selenoprotein P; D051151:Selenoprotein W; D051140:Selenoproteins; D000097564:Iodothyronine Deiodinase Type II
chemical_list: D005979:Glutathione Peroxidase; D007453:Iodide Peroxidase; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D011506:Proteins; D012643:Selenium; D051149:Selenoprotein P; D051151:Selenoprotein W; D051140:Selenoproteins; D000097564:Iodothyronine Deiodinase Type II