[Serotonin and antidepressant treatments: new issues about the therapeutic mechanism of action].
The main mechanism of action of biological therapeutic approaches in the treatment of depression involve the serotonin neurotransmission. Recent data even strong the rol of serotonin in depression and in the therapeutic response. The serotonin works as a trophic factor, participating in the neural tissue homeostasis. This is done directely and indirectely participating the serotonin in the modulation of synaptogenesis, the neurogenesis and in the apoptosis. The structural changes within the central nervous system of depressed patients can be reverted, total o partialy, by the antidepressant treatments, through the potentiation of the serotonin activity in their rol as a trophic factor.
Lista Varela
Alvaro
A
alista@chasque.net
D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000187:drug effects; D003865:Major Depressive Disorder / Q000188:drug therapy*; D006801:Humans; D009473:Neuronal Plasticity / Q000187:drug effects; D018019:Receptors, Corticotropin-Releasing Hormone / Q000187:drug effects; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*
D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D017362:Cyclic AMP Response Element-Binding Protein; D018019:Receptors, Corticotropin-Releasing Hormone; D016194:Receptors, N-Methyl-D-Aspartate; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors
Serotonina y tratamientos antidepresivos: nuevas consideraciones sobre el mecanismo de acción terapéutica.