title: Cell-free transmission of a haemic neoplasm in the cockle Cerastoderma edule.
abstract: A haemic neoplasm occurs in populations of the common cockle Cerastoderma edule L. along the coast of Ireland. The morphology, epizootiology and distribution of the disease have previously been described. The aetiology of the neoplasm is unknown. In this study transmission of the neoplasm between cockles was accomplished using both whole neoplastic cells and neoplastic cell-free homogenates which were filtered through 0.45 microm Millipore filters. Successful transmission of the disease has been achieved by both methods. These results indicate that the neoplasm in cockles may have a viral aetiology. Whole neoplastic cell inoculation resulted in a higher level of disease development compared to that of cell-free inoculates. The survival rates of the inoculated groups were compared and a significant decrease in survival was found in those groups which developed the disease.
authors.affiliation: National University of Ireland (UCC), Department of Zoology and Animal Ecology, Lee Maltings, Prospect Row, Cork, Ireland. collinsc@marlab.ac.uk
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Collins
authors.forename: Maire F
authors.initials: MF
authors.lastname: Mulcahy
mesh_terms: D000818:Animals; D018562:Disease Transmission, Infectious / Q000662:veterinary; D008974:Mollusca / Q000821:virology*; D009368:Neoplasm Transplantation / Q000662:veterinary; D009369:Neoplasms / Q000401:mortality / Q000662:veterinary / Q000821:virology; D016019:Survival Analysis