title: EGF-dependent and independent activation of MAP kinase during Drosophila oogenesis.
abstract: Receptor tyrosine kinase (RTK) signaling is involved in multiple cell fate determination during Drosophila oogenesis. To address the problem of signaling specificity, we sought to systematically document the expression pattern of activated MAP kinase, the downstream effector of RTK signaling. We show that MAP kinase is activated in some of the cell types in which Drosophila EGF receptor signaling is known to function. MAP kinase activation is also associated with many cell migration events. Finally, MAP kinase is activated by heat stress without altering follicle cell fates. The implications of these findings are discussed.
authors.affiliation: Laboratory of Cancer Genomics, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
authors.forename: Vincent
authors.initials: V
authors.lastname: Dammai
authors.forename: Tien
authors.initials: T
authors.lastname: Hsu
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster; D004789:Enzyme Activation / Q000502:physiology; D004815:Epidermal Growth Factor / Q000378:metabolism*; D066246:ErbB Receptors / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005854:Germ Cells / Q000166:cytology / Q000201:enzymology; D018882:Heat Stress Disorders / Q000201:enzymology / Q000235:genetics; D020935:MAP Kinase Signaling System / Q000235:genetics*; D008565:Membrane Proteins / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology; D009154:Mutation / Q000235:genetics; D009865:Oocytes / Q000166:cytology / Q000201:enzymology; D009866:Oogenesis / Q000502:physiology*; D006080:Ovarian Follicle / Q000166:cytology / Q000201:enzymology / Q000254:growth & development*; D012333:RNA, Messenger / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000187:drug effects / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D008565:Membrane Proteins; D012333:RNA, Messenger; C081481:Rho protein, Drosophila; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases; D020928:Mitogen-Activated Protein Kinases