title: SNP haplotype tagging from DNA pools of two individuals.
abstract: BACKGROUND
  DNA pooling is a technique to reduce genotyping effort while incurring only minor losses in accuracy of allele frequency estimates for single nucleotide polymorphism (SNP) markers.
  
  
  RESULTS
  We present an algorithm for reconstructing haplotypes (alleles for multiple SNPs on same chromosome) from pools of two individual DNAs, in which Hardy-Weinberg equilibrium conditions or other assumptions are not required. The program outputs, in addition to inferred haplotypes, a minimal number of haplotype-tagging SNPs that are identified after an exhaustive search procedure.
  
  
  CONCLUSIONS
  Our method and algorithms lead to a significant reduction in genotyping effort, for example, in case-control disease association studies while maintaining the possibility of reconstructing haplotypes under very general conditions.
authors.affiliation: Laboratory of Statistical Genetics, Rockefeller University, New York, NY 10021, USA. jhoh@linkage.rockefeller.edu
authors.forename: Josephine
authors.initials: J
authors.lastname: Hoh
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Matsuda
authors.forename: Xu
authors.initials: X
authors.lastname: Peng
authors.forename: Daniela
authors.initials: D
authors.lastname: Markovic
authors.forename: Mark G
authors.initials: MG
authors.lastname: Lathrop
authors.forename: Jurg
authors.initials: J
authors.lastname: Ott
mesh_terms: D000465:Algorithms; D000483:Alleles; D002148:Calmodulin-Binding Proteins / Q000235:genetics; D019295:Computational Biology / Q000379:methods; D003598:Cytoskeletal Proteins / Q000235:genetics; D004247:DNA / Q000032:analysis*; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D000099291:Adducins
chemical_list: D002148:Calmodulin-Binding Proteins; D003598:Cytoskeletal Proteins; D004247:DNA; D000099291:Adducins