Induced oscillations and the distributed cortical sources during the Wisconsin card sorting test performance in schizophrenic patients: new clues to neural connectivity.
Prefrontal dysfunction has been associated with schizophrenia. Activation during Wisconsin card sorting test (WCST) is a common approach used in functional neuroimaging to address this failure. Equally, current knowledge states that oscillations are basic forms of cells-assembly communications during mental activity. Promising results were revealed in a previous study assessing healthy subjects, WCST and oscillations. However, those previous studies failed to meet the functional integration of the network during the WCST in schizophrenics, based on the induced oscillations and their distributed cortical sources. In this research, we utilized the brain electrical tomography (variable-resolution brain electromagnetic tomography) technique to accomplish this goal. Task specific delta, theta, alpha and beta-2 oscillations were induced and simultaneously synchronized over large extensions of cortex, encompassing prefrontal, temporal and posterior regions as in healthy subjects. Every frequency had a well-defined network involving a variable number of areas and sharing some of them. Oscillations at 11.5, 5.0 and 30 Hz seem to reflect an abnormal increase or decrease, being located at supplementary motor area (SMA), left occipitotemporal region (OT), and right frontotemporal subregions (RFT), respectively. Three cortical areas appeared to be critical, that may lead to difficulties either in coordinating/sequencing the input/output of the prefrontal networks-SMA, and retention of information in memory-RFT, both preceded or paralleled by a deficient visual information processing-OT.
González-Hernández
J A
JA
Department of Clinical Neurophysiology, Hermanos Ameijeiras Hospital, Havana, Cuba. fisap@hha.sld.cu
Cedeño
I
I
Pita-Alcorta
C
C
Galán
L
L
Aubert
E
E
Figueredo-Rodríguez
P
P
D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology*; D003071:Cognition; D003344:Cortical Synchronization; D004569:Electroencephalography; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D009415:Nerve Net; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013647:Task Performance and Analysis