Comparative in vitro surveillance of amoxicillin-clavulanic acid and four oral comparators against 21232 clinical isolates from europe.
The present study was conducted to determine the in vitro activity of amoxicillin-clavulanic acid compared to that of four newer antimicrobial agents (ampicillin, azithromycin, cefuroxime and trimethoprim-sulfamethoxazole). All of the agents were tested against 21232 recent clinical isolates encompassing 37 species submitted from 16 European countries between 1997 and 1999. After 20 years of clinical use, amoxicillin-clavulanic acid continues to retain much of its initial activity against targeted gram-positive organisms, selected gram-negative organisms and major respiratory pathogens.
Hoban
D J
DJ
Laboratories International for Microbiology Studies, 2122 Palmer Drive, Schaumburg, IL 60173-3817, USA. dhoban@ihmainc.com
Bouchillon
S K
SK
Johnson
J L
JL
Zhanel
G G
GG
Butler
D L
DL
Saunders
K A
KA
Miller
L A
LA
Poupard
J A
JA
D000284:Administration, Oral; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology*; D000667:Ampicillin / Q000008:administration & dosage / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D017963:Azithromycin / Q000008:administration & dosage / Q000494:pharmacology; D001424:Bacterial Infections / Q000382:microbiology; D002444:Cefuroxime / Q000008:administration & dosage / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D017963:Azithromycin; D002444:Cefuroxime