title: Fragrance allergy and hand eczema - a review.
abstract: Because hand eczema and fragrance allergy are common both among patients and in the general population, simultaneous occurrence by chance must be expected. Fragrances are ubiquitous and a part of many domestic and occupational products intended for hand exposure. The present review is based on a systematic literature research using both a manual and a Medline based search. The search identified 39 studies, including epidemiological patch test studies, general population patch test studies, case studies, and studies of occupational groups. The published data indicate a possible association between fragrance allergy and hand eczema. In future studies, a more detailed exposure assessment is needed, combined with patch test studies among patients with hand eczema tested with relevant fragrance allergens, as well as experimental control exposure studies to specific fragrance allergens on the hands. As exposures to fragrances on the hands are often simultaneous exposures to irritants, this combined exposure approach needs to be considered.
authors.affiliation: Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark. sihe@gentoftehosp.kbhamt.dk
authors.forename: S
authors.initials: S
authors.lastname: Heydorn
authors.forename: T
authors.initials: T
authors.lastname: Menné
authors.forename: J D
authors.initials: JD
authors.lastname: Johansen
mesh_terms: D000328:Adult; D017677:Age Distribution; D000485:Allergens; D003358:Cosmetics / Q000009:adverse effects*; D003718:Denmark / Q000453:epidemiology; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006229:Hand Dermatoses / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects; D011379:Prognosis; D018570:Risk Assessment; D017678:Sex Distribution; D012915:Soaps / Q000009:adverse effects
chemical_list: D000485:Allergens; D003358:Cosmetics; D010476:Perfume; D012915:Soaps