title: [Protein S and ischemic brain disease].
abstract: Ischemic brain disease (IBD) represents clinical entity participating with almost 80% in all vascular brain diseases. Ethiopatogenesis and pathophysiology of the ischemic brain disease are apparently most complex in human medicine. In addition to the significant progression in understanding of ethiopatogenesis and pathophysiology of the ischemic brain disease, we are currently aware of the fact that in one third of these patients the source--the disorder or the disease of crucial importance for this sequence of events in the opposing direction cannot be diagnosed with certainty. This case report presents a 32-year-old patient with the verified ischemic lesion of brain parenchyma, in whom the lowered concentrations of protein S were registered by comprehensive clinical and biochemical examinations. The lower concentrations of protein S are a significant co-factor of anticoagulant system, in the absence of other significant diseases, disorders or abnormalities which could ethiopatogenetically be significant for IBD.
authors.affiliation: Vojnomedicinska akademija, Klinika za neurologiju, Beograd.
authors.forename: Ranko
authors.initials: R
authors.lastname: Raicević
authors.forename: Aco
authors.initials: A
authors.lastname: Jovicić
authors.forename: Slavka
authors.initials: S
authors.lastname: Mandić-Radić
authors.forename: Dragana
authors.initials: D
authors.lastname: Dordević
authors.forename: Ljubo
authors.initials: L
authors.lastname: Marković
authors.forename: Evica
authors.initials: E
authors.lastname: Dincić
mesh_terms: D000328:Adult; D002545:Brain Ischemia / Q000209:etiology*; D002544:Cerebral Infarction / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D018455:Protein S Deficiency / Q000150:complications* / Q000175:diagnosis
vernacular_title: Protein S i ishemijska bolest mozga.