Cystic maculopathy with normal capillary permeability secondary to docetaxel.
BACKGROUND
Cystic maculopathy without leakage on fluorescein angiography has been described in cases of toxicity to niacin. We present a similar case of cystic maculopathy due to docetaxel (Taxotere) in the treatment of breast cancer.


METHODS
A 53-year-old Asian female presented with complaints of decreased vision soon after the initiation of treatment for breast cancer with docetaxel. A cystic maculopathy with a normal fluorescein angiogram was found on examination. Significant improvement in visual acuity along with resolution of the cystic maculopathy was found after changing to an alternate antineoplastic agent.


CONCLUSIONS
Docetaxel may be associated with cystic maculopathy that does not display angiographic evidence of abnormal capillary permeability.
Teitelbaum
Bruce A
BA
Illinois College of Optometry, Chicago 60616, USA. bteitelb@eyecare.ico.edu
Tresley
David J
DJ
D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D002199:Capillary Permeability / Q000502:physiology; D000077143:Docetaxel; D017809:Fatal Outcome; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008269:Macular Edema / Q000139:chemically induced* / Q000503:physiopathology; D008875:Middle Aged; D017239:Paclitaxel / Q000009:adverse effects* / Q000031:analogs & derivatives*; D012171:Retinal Vessels / Q000502:physiology; D043823:Taxoids; D014792:Visual Acuity / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel