Changes in spontaneous baroreflex sensitivity during sleep in humans.
To evaluate changes in the spontaneous baroreflex sensitivity for heart rate and for muscle sympathetic nerve activity (MSNA) during sleep, we simultaneously recorded MSNA from the tibial nerve and monitored ECG, EEG, EOG, EMG and blood pressure during the resting awake stage and sleep. Blood pressure, ECG and MSNA waves were changed to equidistant time series data of each second by cubic spline interpolation. Cross correlations between the MSNA and diastolic blood pressure and between the instantaneous heart rate and systolic blood pressure were analyzed. Spontaneous baroreflex sensitivities for MSNA and for heart rate were assessed from the slope of the regression lines for each. During sleep, the spontaneous baroreflex sensitivity for MSNA gradually decreased as the non-REM sleep stages advanced. Spontaneous baroreflex sensitivity for heart rate did not show any apparent changes. These results suggest that baroreflex modulations for heart rate and for MSNA differ during sleep.
Shamsuzzaman
A S
AS
Department of Autonomic and Behavioral Neurosciences, Division of Higher Nervous Control, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Sugiyama
Y
Y
Okada
H
H
Takeuchi
S
S
Iwase
S
S
Matsukawa
T
T
Mano
T
T
D000328:Adult; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D004562:Electrocardiography; D004569:Electroencephalography; D004576:Electromyography; D004585:Electrooculography; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D009132:Muscles / Q000294:innervation* / Q000502:physiology; D012890:Sleep / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*; D013979:Tibial Nerve / Q000502:physiology; D013997:Time Factors