Antioxidant enzymes and pulmonary function in steel mill welders.
It is known that high levels of nitric oxide and ozone lead to disturbances of the balance between oxidants and antioxidants. The purpose of this study was to investigate ventilatory parameters in relation to the antioxidant status measured as total antioxidant status (TAS), superoxide dismutase (SOD) and catalase (CT). The study group consisted of 94 welders, aged 41.2 +/- 10.0 years, employed in the Steel Mill in Kraków, Poland, and exposed to nitric oxides and ozone in concentrations exceeding the threshold limit values. The control group consisted of 115 unexposed healthy workers aged 40.8 +/- 10.2 years. All the subjects under study were smokers. Determination of ventilatory efficiency was based on a "flow-volume" curve and spirometry. TAS was measured using reagents from the Randox Laboratories Ltd, SOD according to Fridovich and CT with Aebi's method. It was found that in the group of welders, the concentrations of TAS, CT and SOD were lower compared to controls (TAS-1.15/1.33 mmol/ml; CT-18.1/28.4 m/gHb, SOD-767.6/855.6 U/gHb). The incidence of extreme obstructive pulmonary disease and small airway disease in the welder group was more frequent than in controls. Changes in the concentration (or activity) of antioxidant parameters cannot be used as early markers of ventilatory dysfunction, although the values in the lowest class of TAS, SOD and CT showed a significantly larger number of welders than controls.
Stepnewski
Marek
M
Radioligand Laboratory, Faculty of Pharmacy, Jagiellonian University, Kraków, Poland.
Kolarzyk
Emilia
E
Pietrzycka
Agata
A
Kitlinski
Mariusz
M
Helbin
Jadwiga
J
Brzyszczan
Klaudyna
K
D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers; D002374:Catalase / Q000097:blood*; D035061:Control Groups; D006801:Humans; D008875:Middle Aged; D009569:Nitric Oxide / Q000009:adverse effects* / Q000378:metabolism; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D010126:Ozone / Q000009:adverse effects* / Q000378:metabolism; D011044:Poland / Q000453:epidemiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced / Q000453:epidemiology*; D012129:Respiratory Function Tests; D013147:Spirometry; D013482:Superoxide Dismutase / Q000097:blood*; D020711:Threshold Limit Values; D014896:Welding; D000078329:Workforce
D000395:Air Pollutants, Occupational; D000975:Antioxidants; D015415:Biomarkers; D009569:Nitric Oxide; D010126:Ozone; D002374:Catalase; D013482:Superoxide Dismutase