Potential strategies to normalize the levels of homocysteine in chronic renal failure patients.
Recently published evidence suggests that, either than folate therapy, the enhancement of homocysteine remethylation in tissues by correcting the multiple abnormalities of the remethylation pathway in chronic renal failure that extend beyond folate-related disturbances, or else the improved removal of uremic toxins and/or Hcy through intensified dialysis procedures may represent two strategies to normalize total homocysteine in uremic patients.
Massy
Ziad A
ZA
Faculty of Pharmacy, University of Picardie, CHU-Amiens, Amiens, France. massy@necker.fr
D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications / Q000628:therapy*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications*; D014511:Uremia / Q000097:blood / Q000150:complications
D006710:Homocysteine