Screening for hepatitis B virus DNA in serum of organ donors and renal transplant recipients.
In order to determine the impact of screening potential organ donors for hepatitis B virus DNA using a standardized test, the serum of 145 donor candidates was tested. All of the candidates were negative for hepatitis B virus DNA, but the status of one donor was doubtful for hepatitis B virus surface antigen and seven donors tested positive for hepatitis B virus core antibody without hepatitis B virus surface antigen. Nine transplant recipients tested positive for hepatitis B virus surface antibody; they were given kidneys from the donor with a doubtful hepatitis B virus surface antigen result and from four of the seven donors who tested positive for hepatitis B core antibody. Follow-up revealed no case of hepatitis B transmission. In this study, screening for hepatitis B virus DNA was useful and did not lead to donor organ shortage. Patients with hepatitis B virus surface antibodies can safely be given kidneys from donors who are positive for hepatitis B core antibody but negative for hepatitis B virus DNA.
Miédougé
M
M
Laboratoire de Virologie, Hôpital Purpan, CHU Toulouse, Place du Dr Baylac, TSA 40031, 31059, Toulouse Cedex 9, France. miedouge.m@chu-toulouse.fr
Rostaing
L
L
Mansuy
J M
JM
Sandres-Sauné
K
K
Boudet
F
F
Izopet
J
J
D004279:DNA, Viral / Q000097:blood*; D006509:Hepatitis B / Q000175:diagnosis / Q000517:prevention & control* / Q000821:virology; D006510:Hepatitis B Antibodies / Q000097:blood; D006512:Hepatitis B Core Antigens / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007668:Kidney / Q000821:virology; D016030:Kidney Transplantation; D008403:Mass Screening; D016133:Polymerase Chain Reaction; D014019:Tissue Donors
D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens