Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice.
The occupational importance of tellurium and selenium is growing rapidly, but the biochemistry of exposure is poorly understood. Here we report the potential toxic effects of diphenyl diselenide (PhSe)(2), diphenyl ditelluride (PhTe)(2) and Ebselen in rats and mice. The results suggest that (PhTe)(2) is more toxic in rats than mice. (PhSe)(2), (PhTe)(2) and Ebselen are more toxic by intraperitoneal (i.p.) than subcutaneous (s.c.) route. Calculated LD(50) for (PhTe)(2), i.p., was 0.65 micromol/kg in rats and 150 micromol/kg in mice, and LD(50), s.c., was 0.9 micromol/kg in rats and >500 micromol/kg in mice. Calculated LD(50) for Ebselen, i.p., was 400 micromol/kg in rats and 340 micromol/kg in mice and LD(50), s.c., was >500 micromol/kg in both mice and rats. (PhTe)(2) at small doses increased 2-fold serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities in rats. LD(50) for all organochalcogens administrated in mice inhibited blood delta-ALA-D activity. The present study provides evidence for liver and renal toxicity of (PhTe)(2).
Meotti
F C
FC
Departamento de Química, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, SM, RS, CEP 97105-900, Santa Maria, Brazil.
Borges
V C
VC
Zeni
G
G
Rocha
J B T
JB
Nogueira
C W
CW
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001393:Azoles / Q000633:toxicity*; D001555:Benzene Derivatives / Q000633:toxicity*; D001806:Blood Urea Nitrogen; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000201:enzymology; D054833:Isoindoles; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000633:toxicity*; D016566:Organoselenium Compounds / Q000633:toxicity*; D000623:Porphobilinogen Synthase / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
D001393:Azoles; D001555:Benzene Derivatives; D054833:Isoindoles; D009942:Organometallic Compounds; D016566:Organoselenium Compounds; C434247:diphenylditelluride; C061132:diphenyldiselenide; C042986:ebselen; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000623:Porphobilinogen Synthase