title: Morphological manipulation of PC liposome by controlled bolaamphiphile doping.
abstract: The morphological characterization of aqueous dispersions of PC amphiphile and bolaamphiphile AEC was observed by transmission electron microscopy, the measurement of the liposomal membrane fluidity, differential scanning calorimetry, 5(6)-CF release from liposome and zeta potential measurement. Results indicate that the bolaamphiphile AEC can be included within conventional egg-PC liposome bilayer, which leads to the decrease of liposomal membrane fluidity (P) and the release behavior of 5(6)-CF. This behavior could be due to the property of bolaamphiphile AEC and the good miscibility of bolaamphiphile AEC with PC.
authors.affiliation: The Key Laboratory of Molecular and Biomolecular Electronics of Ministry of Education, Southeast University, Nanjing 210096, China. zouaihua@seu.edu.cn
authors.forename: Zou
authors.initials: Z
authors.lastname: Aihua
authors.forename: Gu
authors.initials: G
authors.lastname: Qiang
authors.forename: Xu
authors.initials: X
authors.lastname: Jun
authors.forename: Yuan
authors.initials: Y
authors.lastname: Chunwei
mesh_terms: D002152:Calorimetry, Differential Scanning; D004563:Electrochemistry; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism; D008560:Membrane Fluidity; D008854:Microscopy, Electron; D010743:Phospholipids / Q000737:chemistry* / Q000378:metabolism; D013501:Surface-Active Agents / Q000737:chemistry* / Q000378:metabolism; D013696:Temperature; D013997:Time Factors
chemical_list: D008081:Liposomes; D010743:Phospholipids; D013501:Surface-Active Agents