Discriminative-stimulus effects of triazolam in light and moderate drinkers.
BACKGROUND
The results of previous laboratory experiments with humans suggest that light and moderate drinkers respond differentially to the effects of benzodiazepines. The aim of this study was to further assess the behavioral effects of a benzodiazepine in light and moderate drinkers.


METHODS
To accomplish this aim, 12 volunteers (6 light drinkers and 6 moderate drinkers) learned to discriminate 0.375 mg of triazolam, a triazolobenzodiazepine hypnotic. After they learned this discrimination, a test-of-novel-doses phase was conducted in which a range of doses of triazolam (0, 0.06, 0.125, 0.25, and 0.375 mg) was tested in both groups of volunteers. The subject-rated and performance-impairing effects of triazolam were assessed concurrently.


RESULTS
There was not a significant difference between the groups in terms of the number of trials needed to learn the discrimination, nor did the proportion of light and moderate drinkers who learned to accurately discriminate 0.375 mg of triazolam differ significantly. The discriminative-stimulus, subject-rated, and performance-impairing effects of triazolam were an orderly function of dose but did not differ across the light and moderate drinkers.


CONCLUSIONS
Future studies should examine the discriminative-stimulus effects of a lower dose of triazolam (e.g., 0.25 mg) in light and moderate drinks or use a fading procedure to determine differences in terms of the lowest discriminable dose.
Rush
Craig R
CR
Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, USA. crush2@uky.edu
Kelly
Thomas H
TH
Fillmore
Mark T
MT
Hays
Lon R
LR
D000328:Adult; D000428:Alcohol Drinking / Q000523:psychology*; D000704:Analysis of Variance; D004193:Discrimination Learning / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D011795:Surveys and Questionnaires; D014229:Triazolam / Q000494:pharmacology*
D014229:Triazolam