Resistin: molecular history and prognosis.
Obesity and diabetes have reached epidemic proportions worldwide. The antidiabetic thiazolidinedione (TZD) drugs are insulin-sensitizing agents now widely used in the treatment of type 2 diabetes. TZDs are ligands for the nuclear hormone receptor peroxisome proliferator activated receptor gamma, which is a master regulator of adipogenesis and adipocyte metabolism. The molecular mechanisms by which TZDs improve insulin sensitivity have not been fully identified. Here we consider a novel secreted factor first identified as a TZD-suppressible gene in mouse adipocytes, called resistin, and discuss what is currently known about resistin regulation and function in mouse and human.
Banerjee
Ronadip R
RR
Division of Endocrinology, Diabetes, and Metabolism, Penn Diabetes Center, University of Pennsylvania School of Medicine, 415 Curie Blvd., Philadelphia, PA 19104-6149, USA.
Lazar
Mitchell A
MA
D000595:Amino Acid Sequence; D000818:Animals; D005786:Gene Expression Regulation; D005938:Glucocorticoids / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006729:Hormones, Ectopic / Q000235:genetics* / Q000502:physiology*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D051379:Mice; D008969:Molecular Sequence Data; D041681:NIH 3T3 Cells; D020932:Nerve Growth Factor; D009765:Obesity / Q000235:genetics; D017434:Protein Structure, Tertiary; D011506:Proteins; D052243:Resistin; D017386:Sequence Homology, Amino Acid; D045162:Thiazolidinediones / Q000627:therapeutic use
D005938:Glucocorticoids; D006729:Hormones, Ectopic; D007004:Hypoglycemic Agents; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D011506:Proteins; C486574:RETNLB protein, human; D052243:Resistin; C499623:Retn protein, mouse; C413576:Retnla protein, mouse; D045162:Thiazolidinediones; D020932:Nerve Growth Factor; C089946:2,4-thiazolidinedione; D005947:Glucose