title: Malignant transformation of renal angiomyolipoma.
abstract: In the present paper, two cases of malignant transformation of renal angiomyolipoma without tuberous sclerosis are reported. Pathological examination revealed that, in both cases, in addition to the areas affected by typical angiomyolipoma, there were areas that contained elevated numbers of perivascular epithelioid cells with prominent nuclear pleomorphism. Immunohistochemical examination revealed that both cases were negative for keratin and epithelial membrane antigen, but were positive for the melanogenesis-related marker HMB-45. Metastatic diseases appeared 40 months after radical nephrectomy in the first case and 18 months in the second case.
authors.affiliation: Department of Urology, Hirosaki University School of Medicine, Aomori, Japan. nobu.ta@abelia.ocn.ne.jp
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Takahashi
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kitahara
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Hishimoto
authors.forename: Akimitsu
authors.initials: A
authors.lastname: Ohguro
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Tadashi
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000328:Adult; D018207:Angiomyolipoma / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008113:Liver Neoplasms / Q000556:secondary*; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D009392:Nephrectomy; D012186:Retroperitoneal Neoplasms / Q000556:secondary* / Q000601:surgery; D013160:Splenic Neoplasms / Q000556:secondary* / Q000601:surgery