title: Immunogenicity of purified chick embryo cell anti-rabies vaccine in post-exposure treatment of animal bite cases.
abstract: The observations on immunogenicity of Purified Chick Embryo Cell (PCEC) anti rabies vaccination in post-exposure prophylaxis is reported. In total 207 serum samples collected from patients receiving 3 to 6 doses of PCEC were analysed for the presence of anti-rabies antibodies. The samples were collected from 10 days to 11 months after the last dose of vaccine. All the vaccinees (n=33) tested after 3 doses of PCEC showed protective titres (> or = 0.5 IU/ml) and those receiving 5-6 doses (n=161) showed 4-5 times higher than protective titres. The analysis pertains to specimens collected at one point of time only after the vaccination. However, in all 17 vaccinees where samples were collected 7-11 months after 3-6 doses of vaccine, the protective titres were sustained, these being 3-4 times higher than the protective titres in those receiving 5-6 vaccine doses. The results indicated that there was no need of routine anti-rabies antibody monitoring in healthy individuals receiving post-exposure prophylaxis in recommended doses of vaccine.
authors.affiliation: National Institute of Communicable Diseases, 22-Shamnath Marg, Delhi-110 054.
authors.forename: Mohan
authors.initials: M
authors.lastname: Bhardwaj
authors.forename: Dipesh
authors.initials: D
authors.lastname: Bhattacharya
authors.forename: Mala
authors.initials: M
authors.lastname: Chhabra
authors.forename: R L
authors.initials: RL
authors.lastname: Ichhpujani
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D001733:Bites and Stings; D002642:Chick Embryo / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D011818:Rabies / Q000276:immunology / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines