title: Antitrichomonas in vitro activity of Cussonia holstii Engl.
abstract: Cussonia holstii is a traditional medicinal plant used in Kenya, which has not been studied chemically up-to-date. Upon biological screening, a substantial antitrichomonas activity was found in the dichloromethane extract of the bark of Cussonia holstii. A detailed chromatographic study using centrifugal partition chromatography revealed that a pentacyclic triterpenoid, i.e., hederagenin, is the antitrichomonas constituent of the plant with a IC50 of 2.8 microM.
authors.affiliation: Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, 9000 Ghent, Belgium.
authors.forename: Weidong
authors.initials: W
authors.lastname: He
authors.forename: Luc
authors.initials: L
authors.lastname: Van Puyvelde
authors.forename: Louis
authors.initials: L
authors.lastname: Maes
authors.forename: Jan
authors.initials: J
authors.lastname: Bosselaers
authors.forename: Norbert
authors.initials: N
authors.lastname: De Kimpe
mesh_terms: D000818:Animals; D000994:Antitrichomonal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D027481:Araliaceae; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50; D009828:Oleanolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D014246:Trichomonas vaginalis / Q000187:drug effects*
chemical_list: D000994:Antitrichomonal Agents; D010936:Plant Extracts; D009828:Oleanolic Acid; C025763:hederagenin