Yeast POL5 is an evolutionarily conserved regulator of rDNA transcription unrelated to any known DNA polymerases.
We show that yeast protein Yel055cp, which has been identified as the fifth essential DNA polymerase in Saccharomyces cerevisiae (POL5), is a member of a family of predicted rDNA transcription regulators (typified by human MYB-binding protein MYBBP1 A), which are represented by a single ortholog in all animals, fungi and plants with sequenced genomes. These proteins are confidently predicted to have an entirely a-helical structure and are unrelated to the B class DNA polymerases, as claimed for yeast POL5, or any other known polymerases.
Yang
Wei
W
National Center for Biotechnology Inforamtion, National Library of Medicine, National Institutes of Health; Bethesda, Maryland 20894, USA.
Rogozin
Igor B
IB
Koonin
Eugene V
EV
D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D004275:DNA, Ribosomal / Q000235:genetics; D004259:DNA-Directed DNA Polymerase / Q000145:classification* / Q000235:genetics* / Q000502:physiology; D019143:Evolution, Molecular; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D008969:Molecular Sequence Data; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000145:classification / Q000235:genetics* / Q000502:physiology; D016415:Sequence Alignment; D014158:Transcription, Genetic
D004275:DNA, Ribosomal; D029701:Saccharomyces cerevisiae Proteins; D004259:DNA-Directed DNA Polymerase; C482399:POL5 protein, S cerevisiae