Sensitivity analysis of stoichiometric networks: an extension of metabolic control analysis to non-steady state trajectories.
A sensitivity analysis of general stoichiometric networks is considered. The results are presented as a generalization of Metabolic Control Analysis, which has been concerned primarily with system sensitivities at steady state. An expression for time-varying sensitivity coefficients is given and the Summation and Connectivity Theorems are generalized. The results are compared to previous treatments. The analysis is accompanied by a discussion of the computation of the sensitivity coefficients and an application to a model of phototransduction.
Ingalls
Brian P
BP
Control and Dynamical Systems, California Institute of Technology, Mail Code 107-81 1200 East California Blvd., Pasadena, CA 91125, USA. ingalls@cds.caltech.edu
Sauro
Herbert M
HM
D000818:Animals; D001683:Biological Clocks / Q000502:physiology; D019295:Computational Biology; D008660:Metabolism; D008954:Models, Biological; D013598:Systems Theory; D014785:Vision, Ocular