title: Endothelial nitric oxide synthase gene polymorphism in the Indian and Mestizo populations of Mexico.
abstract: Endothelium-derived nitric oxide (NO) is an important factor in vasodilation synthesized by endothelial nitric oxide synthase (eNOS). A polymorphism (894 G to T) in exon 7 of the eNOS gene causes the conversion of Glu to Asp in position 298. The Glu298Asp polymorphism has been extensively associated with cardiovascular disease. We determined the Glu298Asp polymorphism frequency in healthy Mexican Mestizo, Huastec, Mayo, and Mayan populations by the endonuclease restriction method. The four populations analyzed were in Hardy-Weinberg equilibrium. Allele frequencies were similar among Mexican populations but different when compared with Caucasians. However, when compared with allele frequencies in Asian populations, Mestizo and Huastec allele frequencies were significantly different. Genotypically, only the Mestizos presented Asp298 homozygosity. The absence of double mutants in Indian populations resembles that in Asians. With these data, we conclude that the low frequency of the eNOS Glu298Asp polymorphism in Indian and Mestizo populations of Mexico is related to the Asian origin of Amerindian groups.
authors.affiliation: Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, México, D.F. México.
authors.forename: Haydeé
authors.initials: H
authors.lastname: Rosas-Vargas
authors.forename: Adrián
authors.initials: A
authors.lastname: Flores-Segura
authors.forename: Boris
authors.initials: B
authors.lastname: Guizada-Claure
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.forename: Julio
authors.initials: J
authors.lastname: Granados
authors.forename: Fabio
authors.initials: F
authors.lastname: Salamanca
authors.forename: Ramón
authors.initials: R
authors.lastname: Coral-Vázquez
mesh_terms: D000483:Alleles; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007197:Indians, Central American / Q000235:genetics*; D008297:Male; D008800:Mexico; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III; D011110:Polymorphism, Genetic
chemical_list: C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III