Bone remodeling markers in the detection of bone metastases in prostate cancer.
BACKGROUND
Early detection of bone metastases in prostatic carcinoma is very useful in treatment and prognosis of the disease. The aim of this work was to evaluate the sensitivity and specificity of a group of bone markers in order to discriminate between prostate carcinoma patients without (M(0)) and with (M(1)) bone metastases.


METHODS
Sixty-seven non-treated patients with: benign prostate hyperplasia (n=21), prostatic carcinoma in several stages without bone metastases (T(X)M(0)) (n=31) and with bone metastases (T(X)M(1)) (n=15) were studied. The following markers were studied: (A) bone formation: (1) serum bone alkaline phosphatase, IRMA (Tandem Ostase, Beckman); (2) serum procollagen I amino-terminal propeptide (PINP), RIA (Orion Diagnostica); (B) bone resorption: (1) urinary collagen I amino-terminal telopeptide (NTX), ELISA (Ostex); (2) collagen I carboxy terminal telopeptide (CTX): (2A) urinary alpha-CTX, RIA (Osteometer), (2B) serum beta-CTX, Elecsys (Roche); (3) collagen I cross-linked carboxy terminal telopeptide (ICTP), RIA (Orion Diagnostica).


RESULTS
Levels of all bone markers were significantly higher in group M(1) than in group M(0). A complete separation of groups M(0) and M(1) was achieved with PINP and beta-CTX (100% sensitivity and specificity).


CONCLUSIONS
These results support the use of PINP or beta-CTX as a tool to confirm the presence or absence of bone metastases in the first staging of prostatic carcinoma patients.
de la Piedra
Concepción
C
Bone Pathophysiology Section, Biochemistry Laboratory, Fundación Jiménez Di;az, Avenida Reyes Católicos 2, 28040- Madrid, Spain.cpiedra@fjd.es
Castro-Errecaborde
Nilda-Adriana
NA
Traba
Maria Luisa
ML
Méndez-Dávila
Cioly
C
García-Moreno
Carmen
C
Rodriguez de Acuña
Lucrecia
L
Rodriguez-Molina
Jesus
J
D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood* / Q000652:urine; D001859:Bone Neoplasms / Q000097:blood / Q000378:metabolism* / Q000556:secondary* / Q000652:urine; D024042:Collagen Type I / Q000097:blood / Q000737:chemistry / Q000652:urine; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D010446:Peptide Fragments / Q000097:blood / Q000652:urine; D011347:Procollagen / Q000097:blood / Q000737:chemistry; D011470:Prostatic Hyperplasia / Q000097:blood / Q000378:metabolism / Q000652:urine; D011471:Prostatic Neoplasms / Q000097:blood / Q000378:metabolism* / Q000473:pathology* / Q000652:urine; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor; D024042:Collagen Type I; D007527:Isoenzymes; D010446:Peptide Fragments; D011347:Procollagen; D000469:Alkaline Phosphatase