Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes.
Ghrelin is a novel gastrointestinal peptide that stimulates growth hormone secretion, food intake, and body weight gain. Increased ghrelin secretion has been reported in such negative energy states as starvation and low body weight. We investigated the dynamics of ghrelin in rats with streptozotocin-induced diabetes, because they present reduced body weight and hyperphagia. The plasma ghrelin levels and gastric preproghrelin mRNA expression levels of the diabetic rats increased significantly and their gastric ghrelin levels decreased significantly. Negative energy balance may enhance preproghrelin mRNA expression and ghrelin secretion into the bloodstream.
Masaoka
Tatsuhiro
T
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Suzuki
Hidekazu
H
Hosoda
Hiroshi
H
Ota
Takayuki
T
Minegishi
Yuriko
Y
Nagata
Hiroshi
H
Kangawa
Kenji
K
Ishii
Hiromasa
H
D000818:Animals; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D005753:Gastric Mucosa / Q000378:metabolism; D054439:Ghrelin; D008297:Male; D009037:Motilin / Q000096:biosynthesis / Q000235:genetics; D036361:Peptide Hormones / Q000097:blood* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar
D054439:Ghrelin; D036361:Peptide Hormones; D012333:RNA, Messenger; D009037:Motilin