title: Human T-cell lymphotropic virus type 1-associated retinal vasculitis in children.
abstract: OBJECTIVE
  To describe predominant retinal vasculitis in children carrying human T-cell lymphotropic virus type 1 (HTLV-1).
  
  
  METHODS
  The authors examined clinical records of patients with HTLV-1-associated uveitis between 1987 and 2001 in Kagoshima University Hospital and reviewed cases of extensive, smoldering retinal vasculitis.
  
  
  RESULTS
  Three previously healthy teenagers noted mild visual symptoms and presented with extensive sheathing of retinal vessels, complicated by mild anterior segment inflammation. The retinal vascular disease responded poorly to systemic corticosteroids, had a smoldering course with persistent sheathing of retinal vessels, and eventually resulted in diffuse chorioretinal degeneration. Results of laboratory studies were unremarkable except for the presence of serum antibodies to HTLV-1. One patient developed HTLV-1-associated myelopathy 11 years after the onset of ocular disease.
  
  
  CONCLUSIONS
  The retinal vasculitis differed from the retinal vascular changes commonly seen in HTLV-1-associated uveitis. The authors suggest a clinical disease HTLV-1-associated retinal vasculitis that affects young HTLV-1 carriers, characterized by smoldering retinal vasculitis with ultimate retinal degeneration.
authors.affiliation: Department of Ophthalmology, Kagoshima University Faculty of Medicine, 8-35-1 Sakuragaoka, Kagoshima-shi 890-8520, Japan. nakao@m2.kufm.kagoshima-u.ac.jp
authors.forename: Kumiko
authors.initials: K
authors.lastname: Nakao
authors.forename: Norio
authors.initials: N
authors.lastname: Ohba
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D015480:Deltaretrovirus Antibodies / Q000097:blood; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods; D005654:Fundus Oculi; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology; D012162:Retinal Degeneration / Q000453:epidemiology / Q000209:etiology; D031300:Retinal Vasculitis / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D014605:Uveitis / Q000150:complications / Q000821:virology
chemical_list: D015480:Deltaretrovirus Antibodies