A novel microgravimetric DNA sensor with high sensitivity.
A novel method using an amplifier with a cantilever and gold nanoparticles successfully to extend the length of the target for the specific and high sensitive detection of DNA was reported. When the size of gold nanoparticle is 50 nm, a sensitivity of 10(-15)M for the single base mutation detection has been achieved.
Liu
Tao
T
Key Laboratory of Colloid and Interface Science, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, 100080, Beijing, China. leotao1974@yahoo.com <leotao1974@yahoo.com>
Tang
Ji'an
J
Han
Meimei
M
Jiang
Long
L
D001483:Base Sequence; D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000032:analysis* / Q000737:chemistry; D004252:DNA Mutational Analysis; D006046:Gold / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D011791:Quartz / Q000737:chemistry; D012680:Sensitivity and Specificity
D011791:Quartz; D006046:Gold; D004247:DNA