Comparison of the effect of NT-0409 and antidementia drugs on learning and memory in rats with chronic cerebral cholinergic deficiency.
Systemic oral administration of NT-0409, a new synthetic agonist of AMPA subtype glutamate receptor, to rats with chronic partial AF64A-induced deprivation of cholinergic functions improved their learning in a Morris water maze. NT-0409 is close to memantine by the effect on learning and, in contrast to cholinomimetic arisept, ensures longer retention of the developed habit.
Lermontova
N N
NN
Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka. nnlermon@mail.ru
Mukhina
T V
TV
Van'kin
G I
GI
Serkova
T P
TP
Bachurin
S O
SO
D000544:Alzheimer Disease / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D001388:Aziridines / Q000633:toxicity; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002794:Choline / Q000031:analogs & derivatives* / Q000633:toxicity; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008559:Memantine / Q000494:pharmacology; D008568:Memory / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000819:agonists*
D001388:Aziridines; D018690:Excitatory Amino Acid Agonists; D018091:Receptors, AMPA; C044894:ethylcholine aziridinium; D002794:Choline; D008559:Memantine