Phenolic glycosides from Symplocos racemosa: natural inhibitors of phosphodiesterase I.
One new phenolic glycoside named benzoylsalireposide (1) along with one known phenolic glycoside named salireposide (2) have been isolated from Symplocos racemosa. Four other known compounds i.e. beta-amyrin (3), oleonolic acid (4), beta-sitosterol (5) and beta-sitosterol glycoside (6) were also isolated from this plant. The structure elucidation of the isolated compounds was based primarily on 1D- and 2D-NMR analysis, including COSY, HMQC, and HMBC correlations. The compound 1 and 2 showed inhibitory activity against snake venom phosphodiesterase I.
Ahmad
Viqar Uddin
VU
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. vuahmad@cyber.net.pk
Abbasi
Muhammad Athar
MA
Hussain
Hidayat
H
Akhtar
Muhammad Nadeem
MN
Farooq
Umar
U
Fatima
Naheed
N
Choudhary
M Iqbal
MI
D000818:Animals; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D043264:Phosphodiesterase I; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry; D012910:Snake Venoms / Q000201:enzymology
D006027:Glycosides; D010636:Phenols; D010726:Phosphodiesterase Inhibitors; D012910:Snake Venoms; D010727:Phosphoric Diester Hydrolases; D043264:Phosphodiesterase I; C470790:phosphodiesterase I, snake venom