title: Calibration and validation of a quality assurance system for 90Sr/90Y radiation source trains.
abstract: A quality assurance system (OPTIDOS, PTW-Freiburg) developed for dose rate verification of 90Sr/90Y radiation source trains (RSTs) was calibrated and validated. These source trains are used in the 5-F-BetaCath system (Novoste Corp.) for the treatment of endovascular diseases. The calibration factor of the OPTIDOS system was obtained empirically and is valid for 90Sr/90Y dose rate measurements at the specification point which is located at 2 mm distance from the source axis. A total of 187 OPTIDOS dose rate verifications of the 5-F-BetaCath system were performed in different hospitals. The histogram of the deviation between the manufacturer's dose rate specification and the dose rate measured using the OPTIDOS dosimetry system is Gaussian shaped with +/- 3% relative width and a mean shift of about +2% with respect to the corresponding dose rate specification. Additionally, 128 OPTIDOS dose rate verifications of the new jacketed RST (3.5-F-BetaCath, Novoste Corp.) were performed using the same calibration factor as derived for the 5-F-BetaCath system. Distribution of the deviation between the certified and the measured dose rate is nearly identical in comparison to the histogram of the 5-F-BetaCath system. The mean value of the deviations is shifted by -1.5% with respect to the certified dose rate. In order to compare the results of the calibrated OPTIDOS dosimetry system with a standard measuring method, separate dose rate measurements were performed using electron accelerator calibrated radiochromic films in which calibration is traceable to PTB (Physikalisch Technische Bundesanstalt, Germany). Deviation between both the methods is less than 3.1%. These results confirm that the calibrated OPTIDOS dosimetry system can be considered suitable for quality assurance of both types of RST used in the BetaCath systems.
authors.affiliation: Department of Radiation Therapy and Oncology, Freie Universität Berlin, Benjamin Franklin University Medical Centre, Hindenburgdamm 30, D-12200 Berlin, Germany. peter.rosenthal@medizin.fu-berlin.de
authors.forename: P
authors.initials: P
authors.lastname: Rosenthal
authors.forename: W
authors.initials: W
authors.lastname: Weber
authors.forename: A
authors.initials: A
authors.lastname: Förster
authors.forename: O
authors.initials: O
authors.lastname: Orth
authors.forename: B
authors.initials: B
authors.lastname: Köhler
authors.forename: F
authors.initials: F
authors.lastname: Seiler
mesh_terms: D001610:Beta Particles; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D002138:Calibration; D004867:Equipment Design; D005373:Film Dosimetry; D006801:Humans; D011785:Quality Assurance, Health Care / Q000379:methods / Q000592:standards; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods / Q000592:standards*; D011879:Radiotherapy Dosage / Q000592:standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013326:Strontium Radioisotopes / Q000032:analysis* / Q000592:standards / Q000627:therapeutic use; D014652:Vascular Diseases / Q000532:radiotherapy; D015021:Yttrium Radioisotopes / Q000032:analysis* / Q000592:standards / Q000627:therapeutic use
chemical_list: D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes