Mutation modulating activity in human serum factors induced after parabolic flight.
We have reported that human interferon, one of cytokines present in serum, can confer hypomutability on various human cells. On the contrary, we have also reported that serum factors from cancer patients can enhance cell mutability. Therefore, it seems likely that cell mutability is changed by cytokine-like serum factors in our body. It is one of important space problems whether the mutability of human cells is regulated in response to microgravity and hypergravity (gravitational stress). However, there is little information about cell mutability during such stress. In this study, we investigated whether the mutability is changed by exposing cells to human serum factors after gravitational stress.
Takahashi
S
S
Department of Biochemistry 2, Chiba University School of Medicine, Japan.
Chi
X J
XJ
Nomura
J
J
Sugaya
S
S
Kita
K
K
Suzuki
N
N
D000328:Adult; D010450:Endopeptidases / Q000187:drug effects / Q000378:metabolism; D005260:Female; D011905:Genes, ras / Q000187:drug effects / Q000235:genetics; D006801:Humans; D018471:Hypergravity; D007155:Immunologic Factors / Q000494:pharmacology; D016898:Interferon-alpha / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D016296:Mutagenesis; D009154:Mutation; D010958:Plasminogen; D013026:Space Flight; D014893:Weightlessness
D007155:Immunologic Factors; D016898:Interferon-alpha; D008769:Methylnitronitrosoguanidine; D010958:Plasminogen; D010450:Endopeptidases