title: AACR Special Conference in cancer research: ubiquitination in normal and cancer cells.
abstract: The AACR Special Conference 2002 for Ubiquitination in Normal and Cancer Cells took place in Vancouver, BC, Canada. It was, indeed, special: a "special" location, a "special" audience and excellent talks that gave a detailed insight into the ubiquitination/proteasome-field. The following meeting highlights try to give a summary of some topics covered at the meeting, from basic research to successful applications of therapeutic agents, starting with cellular regulation, describing recently discovered structural features of enzymes involved in de-/ubiquitination, and, finally, presenting proteasome inhibition as a new approach in cancer chemotherapy.
authors.affiliation: Humboldt-University of Berlin, Charite Children's Hospital, Experimental Oncology, Augustenburger Platz 1, 13353 Berlin, Germany. nicole.huebener@charite.de
authors.forename: Nicole
authors.initials: N
authors.lastname: Huebener
authors.forename: Holger N
authors.initials: HN
authors.lastname: Lode
mesh_terms: D000818:Animals; D003546:Cysteine Endopeptidases / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D025801:Ubiquitin / Q000378:metabolism* / Q000627:therapeutic use; D044764:Ubiquitin-Activating Enzymes / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D009097:Multienzyme Complexes; D025801:Ubiquitin; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; D044764:Ubiquitin-Activating Enzymes