title: Fluoride-releasing restorative materials and secondary caries.
abstract: Secondary caries is responsible for 60 percent of all replacement restorations in the typical dental practice. Risk factors for secondary caries are similar to those for primary caries development. Unfortunately, it is not possible to accurately predict which patients are at risk for restoration failure. During the past several decades, fluoride-releasing dental materials have become a part of the dentist's armamentarium. Considerable fluoride is released during the setting reaction and for periods up to eight years following restoration placement. This released fluoride is readily taken up by the cavosurface tooth structure, as well as the enamel and root surfaces adjacent to the restoration. Resistance against caries along the cavosurface and the adjacent smooth surface has been shown in both in vitro and in vivo studies. Fluoride-releasing dental materials provide for improved resistance against primary and secondary caries in coronal and root surfaces. Plaque and salivary fluoride levels are elevated to a level that facilitates remineralization. In addition, the fluoride released to dental plaque adversely affects the growth of lactobacilli and mutans streptococci by interference with bacterial enzyme systems. Fluoride recharging of these dental materials is readily achieved with fluoridated toothpastes, fluoride mouthrinses, and other sources of topical fluoride. This allows fluoride-releasing dental materials to act as intraoral fluoride reservoirs. The improvement in the properties of dental materials with the ability to release fluoride has improved dramatically in the past decade, and it is anticipated that in the near future the vast majority of restorative procedures will employ fluoride-releasing dental materials as bonding agents, cavity liners, luting agents, adhesives for orthodontic brackets, and definitive restoratives.
authors.affiliation: Department of Pathology, Texas Children's Hospital, Houston 77030-2399, USA. mjhicks@texaschildrenshospital.org
authors.forename: John
authors.initials: J
authors.lastname: Hicks
authors.forename: Franklin
authors.initials: F
authors.lastname: Garcia-Godoy
authors.forename: Kevin
authors.initials: K
authors.lastname: Donly
authors.forename: Catherine
authors.initials: C
authors.lastname: Flaitz
mesh_terms: D000293:Adolescent; D000328:Adult; D002327:Cariostatic Agents / Q000737:chemistry* / Q000493:pharmacokinetics; D002648:Child; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000378:metabolism; D003764:Dental Materials / Q000737:chemistry*; D003773:Dental Plaque / Q000737:chemistry; D019232:Dental Restoration Failure; D003793:Dental Restoration, Permanent; D005459:Fluorides / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects; D012008:Recurrence; D012307:Risk Factors; D012463:Saliva / Q000737:chemistry; D013295:Streptococcus mutans / Q000187:drug effects; D014092:Tooth Root / Q000378:metabolism
chemical_list: D002327:Cariostatic Agents; D003764:Dental Materials; D005459:Fluorides