No Nogo: now where to go?
Nogo-A, a reticulon protein expressed by oligodendrocytes, contributes to the axonal growth inhibitory action of central myelin in growth cone collapse and neurite outgrowth in vitro assays, and antibody and inhibitor studies have implicated a role for Nogo in regeneration in the adult CNS in vivo. Three independent labs have now produced Nogo knockout mice with, quite unexpectedly, three different regeneration phenotypes.
Woolf
Clifford J
CJ
Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA. cwoolf@mgh.harvard.edu
D000367:Age Factors; D000818:Animals; D001369:Axons / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D020439:Growth Cones / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009185:Myelin Proteins / Q000172:deficiency* / Q000235:genetics; D009186:Myelin Sheath / Q000502:physiology*; D009416:Nerve Regeneration / Q000235:genetics / Q000502:physiology*; D016501:Neurites / Q000502:physiology; D000070798:Nogo Proteins; D010641:Phenotype; D020033:Protein Isoforms / Q000172:deficiency / Q000235:genetics
D009185:Myelin Proteins; D000070798:Nogo Proteins; D020033:Protein Isoforms; C000603201:Rtn4 protein, mouse