Association study between interleukin-1beta gene (IL-1beta) and schizophrenia.
An increasing amount of evidence suggests that the pathophysiology of schizophrenia is associated with the abnormal immune system, and cytokines may be important in schizophrenia. Among these cytokines, interleukin-1beta may play a role in the pathogenesis of the disease. In the present study, we investigated the genetic association between a TaqI polymorphism in interleukin-1beta gene (IL-1beta) and schizophrenia by restriction fragment length polymorphism (RFLP) analysis among 132 Chinese families of Han descent. The transmission disequilibrium test (TDT) did not demonstrate an allelic association with schizophrenia. Our results suggested that the TaqI polymorphism in IL-1beta gene might not confer increased susceptibility for schizophrenia.
Yang
Jianzhong
J
Institute of Mental Health, Peking University, 100083, Beijing, China.
Si
Tianmei
T
Ling
Yansu
Y
Ruan
Yan
Y
Han
Yonghua
Y
Wang
Xiling
X
Zhou
Mo
M
Zhang
Darong
D
Zhang
Hongyan
H
Kong
Qingmei
Q
Liu
Cui
C
Li
Xueni
X
Yu
Yaqin
Y
Liu
Shuzeng
S
Shu
Liang
L
Ma
Dalong
D
Wei
Jun
J
Zhang
Dai
D
D000293:Adolescent; D000328:Adult; D000483:Alleles; D002681:China; D005260:Female; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics* / Q000378:metabolism; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology
D007375:Interleukin-1