title: Synthesis of the apratoxin 2,4-disubstituted thiazoline via an intramolecular aza-Wittig reaction.
abstract: [reaction: see text] In developing a synthetic entry to the thiazoline-containing domain of the apratoxin natural products, we converted vicinal azido-thiolesters into 2,4-disubstituted thiazolines via sequential one-pot Staudinger reduction/aza-Wittig reaction. This method of de novo thiazoline formation provides a mild and versatile process that is particularly well suited to acid-sensitive substrates.
authors.affiliation: Department of Chemistry, University of Minnesota, 207 Pleasant St. S.E., Minneapolis, Minnesota 55455, USA.
authors.forename: Jiehao
authors.initials: J
authors.lastname: Chen
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Forsyth