In vitro activity of linezolid against slowly growing nontuberculous Mycobacteria.
MICs of linezolid in broth microdilutions were tested against 341 slowly growing nontuberculous mycobacteria (NTM) belonging to 15 species. The proposed linezolid susceptibility MICs for all Mycobacterium marinum, Mycobacterium szulgai, Mycobacterium kansasii, Mycobacterium malmoense, and Mycobacterium xenopi isolates and for 90% of Mycobacterium gordonae and Mycobacterium triplex isolates were </=8 micro g/ml. Linezolid has excellent therapeutic potential against most species of NTM.
Brown-Elliott
Barbara A
BA
Department of Microbiology, The University of Texas Health Center, Tyler, Texas, USA. barbara.elliott@uthct.edu
Crist
Christopher J
CJ
Mann
Linda B
LB
Wilson
Rebecca W
RW
Wallace
Richard J
RJ
D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D009170:Nontuberculous Mycobacteria / Q000187:drug effects*; D023303:Oxazolidinones / Q000494:pharmacology*
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid