[Pharmacokinetics of bromazepam in 57 patients with acute drug intoxication].
Pharmacokinetic parameters of bromazepam were analyzed by 57 cases. The patients were admitted 7.3 +/- 8.9 hours (mean +/- S.D.) after ingestion of 88 +/- 127 mg bromazepam. Most patients had taken several drugs other than bromazepam and the number was 5.5 +/- 2.6 drugs. The serum bromazepam levels were 1,871 +/- 2,428 ng/ml and the elimination half-lives were 29 +/- 4 hours. Increased serum bromazepam levels were followed by extended elimination half-lives. There was no bromazepam toxic sign under 2,300 ng/ml. One case was treated with direct hemoperfusion and the therapy was effective.
Koyama
Kazuhiro
K
National Tokyo Medical Center, Institute for Clinical Research, Department of Pharmacy.
Shimazu
Yoko
Y
Kikuno
Takaaki
T
Kaziwara
Hirosi
H
Sekiguti
Hisanori
H
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics* / Q000506:poisoning*; D001960:Bromazepam / Q000493:pharmacokinetics* / Q000506:poisoning*; D005260:Female; D006207:Half-Life; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001960:Bromazepam