title: Improved exercise tolerance and quality of life with cardiac rehabilitation of older patients after myocardial infarction: results of a randomized, controlled trial.
abstract: BACKGROUND
  Whether cardiac rehabilitation (CR) is effective in patients older than 75 years, who have been excluded from most trials, remains unclear. We enrolled patients 46 to 86 years old in a randomized trial and assessed the effects of 2 months of post-myocardial infarction (MI) CR on total work capacity (TWC, in kilograms per meter) and health-related quality of life (HRQL).
  
  
  RESULTS
  Of 773 screened patients, 270 without cardiac failure, dementia, disability, or contraindications to exercise were randomized to outpatient, hospital-based CR (Hosp-CR), home-based CR (Home-CR), or no CR within 3 predefined age groups (middle-aged, 45 to 65 years; old, 66 to 75 years; and very old, >75 years) of 90 patients each. TWC and HRQL were determined with cycle ergometry and Sickness Impact Profile at baseline, after CR, and 6 and 12 months later. Within each age group, TWC improved with Hosp-CR and Home-CR and was unchanged with no CR. The improvement was similar in middle-aged and old persons but smaller, although still significant, in very old patients. TWC reverted toward baseline by 12 months with Hosp-CR but not with Home-CR. HRQL improved in middle-aged and old CR and control patients but only with CR in very old patients. Complications were similar across treatment and age groups. Costs were lower for Home-CR than for Hosp-CR.
  
  
  CONCLUSIONS
  Post-MI Hosp-CR and Home-CR are similarly effective in the short term and improve TWC and HRQL in each age group. However, with lower costs and more prolonged positive effects, Home-CR may be the treatment of choice in low-risk older patients.
authors.affiliation: Department of Critical Care Medicine and Surgery, University of Florence and Azienda Ospedaliera Careggi, Via delle Oblate, 4. 50141 Florence, Italy. nmarchionni@unifi.it
authors.forename: Niccolò
authors.initials: N
authors.lastname: Marchionni
authors.forename: Francesco
authors.initials: F
authors.lastname: Fattirolli
authors.forename: Stefano
authors.initials: S
authors.lastname: Fumagalli
authors.forename: Neil
authors.initials: N
authors.lastname: Oldridge
authors.forename: Francesco
authors.initials: F
authors.lastname: Del Lungo
authors.forename: Linda
authors.initials: L
authors.lastname: Morosi
authors.forename: Costanza
authors.initials: C
authors.lastname: Burgisser
authors.forename: Giulio
authors.initials: G
authors.lastname: Masotti
mesh_terms: D000368:Aged; D017079:Exercise Tolerance; D005260:Female; D017048:Health Care Costs; D006699:Home Care Services; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000191:economics / Q000534:rehabilitation*; D011788:Quality of Life; D016896:Treatment Outcome