title: [Vulvovaginal candidiasis and sensitivity of pathogens to antimycotics].
abstract: OBJECTIVE
  Analysis of the prevalence and species representation of pathogenic yeasts in patients with vulvovaginal candidiasis. Determination of in vitro susceptibility of yeast isolates to clinically used antimycotic agents.
  
  
  METHODS
  A retrospective clinical study of patients with positive vaginal cultures for the presence of pathogenic yeast species.
  
  
  METHODS
  I. gynekologicko-pôrodnícka klinika LF UK a FN, Zochova 7,811 03 Bratislava, Slovenská republika.
  
  
  METHODS
  Identification of yeast pathogens on the chromogenic medium CHROMagar CANDIDA and with API-CANDIDA identification system. In vitro susceptibility assays of clinical yeast isolates to antifungal agents using the plate dilution method, NCCLS method and ATB-FUNGUS test system.
  
  
  RESULTS
  The highest prevalence of vulvovaginal candidasis was found in women aged between 20-30 years. Candida albicans was the most commonly identified species of pathogenic yeasts (87.4%). Of the non-albicans species, C. glabrata (6.3%) was the most prevalent species. C. glabrata and C. krusei clinical isolates were found to be generally less susceptible to several antifungals in vitro as compared to C. albicans strains. A minimal number of resistant yeast isolates was observed for econazole, clotrimazole and nystatin. A relatively high number of resistant strains was observed for some other azole antifungals (miconazole, ketoconazole, itraconazole, fluconazole).
  
  
  CONCLUSIONS
  A successful treatment of vaginal mycotic infections requires the results of the microbiological analyses. They will bring evidence to a physician of the presence and fate of the pathogen, of its sensitivity to antifungals, both of which are essential for the rational and successful therapy of Candida vaginitis.
authors.affiliation: Gynekologicko-pôrodnícka klinika LFUK a FN, Zochova 7, 811 03 Bratislava.
authors.forename: M
authors.initials: M
authors.lastname: Sojáková
authors.forename: D
authors.initials: D
authors.lastname: Liptajová
authors.forename: M
authors.initials: M
authors.lastname: Simoncicová
authors.forename: M
authors.initials: M
authors.lastname: Borovský
authors.forename: J
authors.initials: J
authors.lastname: Subík
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002181:Candidiasis, Vulvovaginal / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies
chemical_list: D000935:Antifungal Agents
vernacular_title: Vulvovaginálna kandidóza a citlivost patogénov na antimykotiká.