title: Novel antifungal diketopiperazine from marine fungus.
abstract: Marine fungi producing antifungal compounds were screened against Pyricularia oryzae (P. oryzae), and a metabolite of marine fungus M-3 isolated from laver (Porphyra yezoensis) showed potent activity. Novel diketopiperazine (1) was isolated from the culture extracts, and its structure was elucidated by spectroscopic methods. The MIC of 1 against P. oryzae was 0.36 microM.
authors.affiliation: Marine Biotechnology Institute Co. Ltd., Shimizu, Shizuoka 424-0037, Japan bhg@netian.com
authors.forename: Hee-Guk
authors.initials: HG
authors.lastname: Byun
authors.forename: Huiping
authors.initials: H
authors.lastname: Zhang
authors.forename: Masami
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Kyoko
authors.initials: K
authors.lastname: Adachi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Shizuri
authors.forename: Won-Jae
authors.initials: WJ
authors.lastname: Lee
authors.forename: Se-Kwon
authors.initials: SK
authors.lastname: Kim
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D005285:Fermentation; D007659:Ketones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D008970:Molecular Weight; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D012275:Oryza / Q000187:drug effects; D010879:Piperazines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000935:Antifungal Agents; D007659:Ketones; D010879:Piperazines