Highly stereoselective synthesis of novel alpha-haloenamides via a mild and efficient hydrohalogenation of ynamides.
A highly stereoselective preparation of novel chiral (E)-alpha-haloenamides under mild conditions utilizing magnesium halide salts is described. This unexpected mild and efficient hydrohalogenation reaction highlights another synthetic utility of ynamides. [reaction: see text]
Mulder
Jason A
JA
Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Kurtz
Kimberly C M
KC
Hsung
Richard P
RP
Coverdale
Heather
H
Frederick
Michael O
MO
Shen
Lichun
L
Zificsak
Craig A
CA