title: [Contribution of neurotrophic factors and cytokines to schizophrenia].
abstract: Abnormal development of the brain is implicated in the etiology and/or pathology of various psychiatric diseases, including schizophrenia. Current evidence indicates that neurotrophic factors can strongly influence neuronal phenotypic differentiation and subsequent neuronal function in synaptic plasticity. Among various neurotrophic factors, the expression of brain-derived neurotrophic factor(BDNF) and epidermal growth factor (EGF) is impaired in the brain as well as in the periphery of patients with schizophrenia. Based on this result, a novel animal model for schizophrenia has been established by perturbing the neurotrophic signaling during development. This review summarizes the latest progress of these studies.
authors.affiliation: Brain Research Institute, Niigata University.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Futamura
authors.forename: Makoto
authors.initials: M
authors.lastname: Mizuno
authors.forename: Makoto
authors.initials: M
authors.lastname: Takahashi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Toyooka
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Someya
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology; D002454:Cell Differentiation; D016207:Cytokines / Q000502:physiology*; D004195:Disease Models, Animal; D004815:Epidermal Growth Factor / Q000502:physiology; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology*; D009473:Neuronal Plasticity; D009474:Neurons / Q000166:cytology / Q000502:physiology; D012559:Schizophrenia / Q000209:etiology*; D013569:Synapses / Q000502:physiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines; D009414:Nerve Growth Factors; D004815:Epidermal Growth Factor