Gabapentin blocks and reverses antinociceptive morphine tolerance in the rat paw-pressure and tail-flick tests.
Gilron
Ian
I
Department of Anesthesiology, Kingston General Hospital Queen's University, Ontario, Canada. gilroni@post.queensu.ca
Biederman
Jessica
J
Jhamandas
Khem
K
Hong
Murray
M
D000085:Acetates / Q000494:pharmacology*; D000588:Amines; D000701:Analgesics, Opioid / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D000818:Animals; D003509:Cyclohexanecarboxylic Acids; D004195:Disease Models, Animal; D004361:Drug Tolerance; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D000077206:Gabapentin; D008297:Male; D009020:Morphine / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D051381:Rats; D017207:Rats, Sprague-Dawley; D013623:Tail; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000701:Analgesics, Opioid; D003509:Cyclohexanecarboxylic Acids; D018691:Excitatory Amino Acid Antagonists; D009292:Narcotic Antagonists; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D009020:Morphine