Three cases of advanced seminoma and Down's syndrome: a possible association.
This is a report of three cases of classic seminoma in Down's syndrome patients treated at our institution. Review of literature shows an observation of increased occurrence of testicular cancer in patients with DS, however, with no definitive association documented. A brief discussion of the possible pathogenesis is presented.
Hsiung Stripp
Diana C
DC
Department of Radiation Oncology, Hospital of the University of Pennsylvania, 2 Donner Building, 3400 Spruce Street, Philadelphia, PA 19104, U.S.A.
Vaughn
David
D
Van Arsdalen
Keith
K
Whittington
Richard
R
D000328:Adult; D004314:Down Syndrome / Q000150:complications*; D006801:Humans; D008297:Male; D018239:Seminoma / Q000150:complications* / Q000453:epidemiology; D013736:Testicular Neoplasms / Q000150:complications* / Q000453:epidemiology