[Tissue toxicity of antiseptics].
OBJECTIVE
Local antiseptics are used for desinfection of skin and for lavage of wounds. The aim of this study was to determine the tissue toxicity of different antiseptics and to measure the irritation score (IS) and the irritation threshold (IT) for each substance.


METHODS
The tissue compatibilities of Dibromol, Kodan, Jodobac, Octenisept, Lavasept 0.2 %, hydrogen peroxide, chlorhexidindigluconate 0.5 % and 2-propanol 60 % were evaluated in the in vivo hens eggs chorion-allantoic membrane test (HET-CAM).


RESULTS
We found the most severe tissue toxicity for chlorhexidin digluconate 0.5 % (IS 20) and Kodan (IS 18). Irritating values were found for Dibromol (IS 14), Octenisept (IS 14) and 2-propanol 60 % (IS 13). Moderate vascular injuries were caused by Jodobac (IS 2). In the HET-CAM test Lavasept 0.2 % (IS 0) and hydrogen peroxide (IS 0) showed no tissue toxicity.


CONCLUSIONS
Our results show that some of the tested antiseptics might cause severe vascular injuries as a sign of tissue toxicity. The tissue compatibility of Lavasept 0.2 % and hydrogen peroxide is much better than the compatibility of the other tested substances. With focus on the literature and our results, Lavasept 0.2 % can be recommended as the local antiseptic of choice.
Kalteis
T
T
Orthopädische Universitätsklinik Regensburg. thomas.kalteis@klinik.uni-regensburg.de
Lüring
C
C
Schaumburger
J
J
Perlick
L
L
Bäthis
H
H
Grifka
J
J
D000482:Allantois / Q000098:blood supply / Q000187:drug effects; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000009:adverse effects*; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D003875:Drug Eruptions / Q000145:classification*; D006470:Hemorrhage / Q000139:chemically induced; D008833:Microcirculation / Q000187:drug effects; D013927:Thrombosis / Q000139:chemically induced
D000891:Anti-Infective Agents, Local
Gewebetoxizität lokaler Antiseptika.