Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors.
Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS- associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.
Barozzi
Patrizia
P
Department of Oncology and Hematology, University of Modena and Reggio Emilia, Modena, Italy.
Luppi
Mario
M
Facchetti
Fabio
F
Mecucci
Cristina
C
Alù
Milena
M
Sarid
Ronit
R
Rasini
Valeria
V
Ravazzini
Luisa
L
Rossi
Elisa
E
Festa
Silvana
S
Crescenzi
Barbara
B
Wolf
Dana G
DG
Schulz
Thomas F
TF
Torelli
Giuseppe
G
D018952:Antigens, CD34 / Q000032:analysis; D000956:Antigens, Viral; D015234:HLA-A Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D016030:Kidney Transplantation / Q000009:adverse effects*; D014411:Neoplastic Stem Cells / Q000502:physiology*; D009687:Nuclear Proteins; D012514:Sarcoma, Kaposi / Q000209:etiology*; D012730:Sex Chromosomes; D014019:Tissue Donors
D018952:Antigens, CD34; D000956:Antigens, Viral; D015234:HLA-A Antigens; C069526:HLA-A*30 antigen; D006684:HLA-DR Antigens; D009687:Nuclear Proteins; C109540:latency-associated nuclear antigen