title: Role of the F-box protein Skp2 in cell proliferation in the developing auditory system in mice.
abstract: The F-box protein, Skp2 positively regulates the G1-S transition by controlling the stability of several G1 regulators, including p27. To evaluate the role of Skp2 in the mammalian developing auditory systems, the expression of Skp2 was examined together with the expression of p27 in auditory systems. Our data show expression of Skp2 in auditory epithelia and neurons at an early stage of development. During differentiation processes, the onset of p27 expression was observed together with the down-regulation of Skp2 expression, in auditory epithelia. In contrast, an alteration of expression of p27 and Skp2 in the greater epithelial ridge and spiral ganglion appeared after differentiation of hair cells. These findings suggest that Skp2 plays a crucial role in development of mammalian auditory systems.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyo-ku, 606-8507 Kyoto, Japan.
authors.forename: Youyi
authors.initials: Y
authors.lastname: Dong
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Endo
authors.forename: Tae-Soo
authors.initials: TS
authors.lastname: Kim
authors.forename: Fukuichiro
authors.initials: F
authors.lastname: Iguchi
authors.forename: Norio
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Naito
authors.forename: Juichi
authors.initials: J
authors.lastname: Ito
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D003051:Cochlea / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D050760:Cyclin-Dependent Kinase Inhibitor p27; D004398:Dyneins; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D005865:Gestational Age; D006198:Hair Cells, Auditory / Q000166:cytology / Q000378:metabolism; D019394:Ki-67 Antigen / Q000096:biosynthesis; D051379:Mice; D008813:Mice, Inbred ICR; D000081412:Myosin VIIa; D009218:Myosins / Q000096:biosynthesis; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D044786:S-Phase Kinase-Associated Proteins; D013136:Spiral Ganglion / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: C493961:Cdkn1b protein, mouse; D018797:Cell Cycle Proteins; D019394:Ki-67 Antigen; C000631456:Myo7a protein, mouse; D000081412:Myosin VIIa; D044786:S-Phase Kinase-Associated Proteins; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D009218:Myosins; D004398:Dyneins