title: Crucial factors that influence cost-effectiveness of universal hepatitis B immunization in India.
abstract: This study examines the parameters crucial to cost-effectiveness of universal hepatitis B immunization in India. An incremental cost-effectiveness analysis was done using a decision tree (Markov model) to follow up a hypothetical cohort of 100,000 newborns for the effects of hepatitis B acquired vertically at birth. The measure of effectiveness was disability-adjusted life-years gained. Uncertainty analysis and Scenario analysis were done using Latin hypercube sampling. Hepatitis B endemicity is the most important factor, followed by the cost of vaccine. Other factors of some influence are vaccination coverage, vaccine efficacy, HBeAg positivity, and vaccine wastage.
authors.affiliation: Harvard University, USA. charu_prakash@vsnl.com
authors.forename: Charu
authors.initials: C
authors.lastname: Prakash
mesh_terms: D015331:Cohort Studies; D003362:Cost-Benefit Analysis; D003663:Decision Trees; D019353:Endemic Diseases / Q000191:economics; D017048:Health Care Costs; D006302:Health Services Research; D006509:Hepatitis B / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000191:economics; D006801:Humans; D007194:India; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000191:economics; D008390:Markov Chains; D032541:Mass Vaccination / Q000191:economics*; D019057:Quality-Adjusted Life Years; D035501:Uncertainty
chemical_list: D017325:Hepatitis B Vaccines