title: Cerebral correlates of explicit sequence learning.
abstract: Using positron emission tomography (PET) and regional cerebral blood flow (rCBF) measurements, we investigated the cerebral correlates of consciousness in a sequence learning task through a novel application of the Process Dissociation Procedure, a behavioral paradigm that makes it possible to separately assess conscious and unconscious contributions to performance. Results show that the metabolic response in the anterior cingulate/mesial prefrontal cortex (ACC/MPFC) is exclusively and specifically correlated with the explicit component of performance during recollection of a learned sequence. This suggests a significant role for the ACC/MPFC in the explicit processing of sequential material.
authors.affiliation: Cognitive Science Research Unit, Université Libre de Bruxelles, Bruxelles, Belgium. adestre@ulb.ac.be
authors.forename: Arnaud
authors.initials: A
authors.lastname: Destrebecqz
authors.forename: Philippe
authors.initials: P
authors.lastname: Peigneux
authors.forename: Steven
authors.initials: S
authors.lastname: Laureys
authors.forename: Christian
authors.initials: C
authors.lastname: Degueldre
authors.forename: Guy
authors.initials: G
authors.lastname: Del Fiore
authors.forename: Joël
authors.initials: J
authors.lastname: Aerts
authors.forename: André
authors.initials: A
authors.lastname: Luxen
authors.forename: Martial
authors.initials: M
authors.lastname: van der Linden
authors.forename: Axel
authors.initials: A
authors.lastname: Cleeremans
authors.forename: Pierre
authors.initials: P
authors.lastname: Maquet
mesh_terms: D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000502:physiology; D006801:Humans; D007858:Learning / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D013569:Synapses / Q000502:physiology; D014055:Tomography, Emission-Computed