Valanimycin biosynthesis: investigations of the mechanism of isobutylhydroxylamine incorporation.
[reaction: see text] The incorporation of [(15)N, (18)O]-isobutylhydroxylamine into the antibiotic valanimycin by Streptomyces viridifaciens has been shown to proceed with loss of the (18)O label, thereby demonstrating that the azoxy oxygen atom of valanimycin is not derived from the oxygen atom of isobutylhydroxylamine.
Tao
Tao
T
Department of Chemistry MS65, Rice University, 6100 Main St., Houston, Texas 77005, USA.
Alemany
Lawrence B
LB
Parry
Ronald J
RJ
D001391:Azo Compounds / Q000378:metabolism*; D006898:Hydroxylamines / Q000737:chemistry / Q000378:metabolism*; D009587:Nitrogen Isotopes; D010103:Oxygen Isotopes; D013302:Streptomyces / Q000378:metabolism
D001391:Azo Compounds; D006898:Hydroxylamines; D009587:Nitrogen Isotopes; D010103:Oxygen Isotopes; C048267:valanimycin