[Mechanism of action of antiepileptic drugs].
Antiepileptic drugs (DAEs) act through different mechanisms of action: increase in central inhibition, inhibition of excitatorios mechanisms and modification of the excitability through their action on the ionic channels. Epilepsy is characterized by an abnormal and hypersynchronic unloading of a neuronal population. The activity of numerous drugs is associated to increase in gabaergic activity. Another group of drugs decreases excitatory mechanisms, through the inhibition of ionic channels, or through a decrease in the activity of the excitatory neurotransmitters. There are some of antiepileptic drugs, especially within the group of drugs of recent appearance, for wich the mechanism of action remains unknown.
Saidón
Patricia
P
División de Neurología, Hospital Ramos Mejía, Buenos Aires, Argentina. psaidon@anmat.gov.ar
D000927:Anticonvulsants / Q000145:classification / Q000494:pharmacology* / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects*; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D007473:Ion Channels / Q000187:drug effects
D000927:Anticonvulsants; D007473:Ion Channels
Mecanismo de acción de las drogas antiepilépticas.