Genomic imbalances in Korean hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is one of the most prevalent gastrointestinal malignant tumors in Southeast Asia. Thirty-one cirrhotic HCC, 14 noncirrhotic HCC, and 13 metastastic HCC in the Korean population were investigated on microdissected tissues for chromosomal aberrations by degenerate oligonucleotide-primed polymerase chain reaction (PCR) comparative genomic hybridization. A number of prominent sites of genomic imbalances were observed. The gains of 1q, 6p, 7, 8q, 12q, 13q3-q32, 16p, 17q, and 20q and the losses of 1p, 4q, 6q, 8p, 9p, and 13q regions were observed with a similar high frequency in all types. Various chromosomal aberrations were observed preferentially to specific types. Gains of 4p15-pter, 10q24-qter, 18p11-pter, and 19p10-pter and a loss of 11q14-q22 were observed in the cirrhotic HCC, whereas losses of 14q21-q23 and 10q22-q23 were observed in noncirrhotic HCC. In metastatic HCC, gains of 3q25-qter and Xp21-pter and losses of 21q11-qter and Y were observed. The recurrent gains and losses of chromosomal regions identified in this study are consistent with several previous observations and provide possible candidate regions for the involvement of tumorigenesis and progressions of HCC.
Kim
Gi-Jin
GJ
Department of Anatomy, Institute of Human Genetics, Korea University College of Medicine, Seoul, South Korea.
Cho
Seong-Jin
SJ
Won
Nam-Hee
NH
Sung
Jin-Mo
JM
Kim
Hyun
H
Chun
Yong-Hyuck
YH
Park
Sun-Hwa
SH
D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000235:genetics*; D002869:Chromosome Aberrations; D006801:Humans; D007723:Korea / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D014178:Translocation, Genetic / Q000235:genetics