title: Flumazenil-induced ballism.
abstract: Flumazenil, an imidazobenzodiazepine, is the first benzodiazepine antagonist and is being used to reverse the adverse pharmacological effects of benzodiazepine. There have been a few reports on the central nevous system side effects with its use. We report a patient with generalized ballism following administration of flumazenil. The mechanism through which flumazenil induced this symptom is unknown. It is conceivable that flumazenil may antagonize the GABA-benzodiazepine receptor complex and induce dopamine hypersensitivity, thus induce dyskinesic symptoms.
authors.affiliation: Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea. ks1007@cmc.cuk.ac.kr
authors.forename: Joong-Seok
authors.initials: JS
authors.lastname: Kim
authors.forename: Seok-Bum
authors.initials: SB
authors.lastname: Ko
authors.forename: Yeong-Bin
authors.initials: YB
authors.lastname: Choi
authors.forename: Kwang-Soo
authors.initials: KS
authors.lastname: Lee
mesh_terms: D003937:Diagnosis, Differential; D020820:Dyskinesias / Q000209:etiology*; D005260:Female; D005442:Flumazenil / Q000009:adverse effects*; D018757:GABA Modulators / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged
chemical_list: D018757:GABA Modulators; D005442:Flumazenil