[Effect of fexofenadine--selective antagonist of histamine receptor (H1) on histamine-induced bronchoconstriction].
The aim of the study was to evaluate the effect of single and repeated fexofenadine (120 mg/day) doses on histamine-induced bronchoconstriction. Sixteen patients with mild, stabile asthma were examined. Bronchial reactivity was estimated as histamine dose (in mg/ml) causing a 20% FEV1 fall. A significant blockade of histamine H1 receptors in the airways was observed from the 1st to the 3rd day of the study. In all patients treated with fexofenadine, histamine in 16 mg/ml dose failed to induce bronchoconstriction. After another three days without fexofenadine, bronchial responsiveness returned to the initial value. The study points out that fexofenadine blocks H1 receptors in the bronchial tree.
Grzelewska-Rzymowska
Iwona
I
Klinika Gruzlicy i Chorób Płuc Instytutu Medycyny Wewnetrznej Uniwersytetu Medycznego w Łodzi. rzym@binar.com.pl
Kroczyńska-Bednarek
Jadwiga
J
Pietrzkowicz
Magdalena
M
D000328:Adult; D018926:Anti-Allergic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006632:Histamine; D006634:Histamine H1 Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011969:Receptors, Histamine H1 / Q000187:drug effects; D016593:Terfenadine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
D018926:Anti-Allergic Agents; D006634:Histamine H1 Antagonists; D011969:Receptors, Histamine H1; D016593:Terfenadine; D006632:Histamine; C093230:fexofenadine
Wpływ feksofenadyny--wybiórczego antagonisty receptorów H1--na skurcz oskrzeli wywołany wziewaniem histaminy.