title: Patients with unstable angina pectoris present increased humoral response against Helicobacter pylori in comparison with patients with aggravated dyspepsia.
abstract: A role of autoimmune process and its link with bacterial infections in initiation or aggravation of atherosclerosis symptoms has been suggested. Antigenic mimicry and cross-reactivity of circulating antibodies have been indicated as some major factors in this process. In this study, the prevalence and titers of IgG and IgA antibodies reacting with glycine extract of H. pylori surface antigens were determined immunoenzymatically (ELISA) in the group of patients with unstable ischaemic heart disease and in patients with aggravated dyspepsia. Our results reveal that elevated titers of IgG anti-H. pylori are more typical for cardiac patients and lower prevalence of IgA anti-H. pylori--for those with aggravated dyspepsia. This supports the hypothesis that intensed humoral response in immunoglobulins class G against some bacterial antigens may play a role in the aggravation of symptoms of coronary atherosclerosis.
authors.affiliation: Department of Cardiology IMW, Medical University, ul. Kniaziewicza 1/5, 91-347 Lódź, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Rechciński
authors.forename: Jarosław D
authors.initials: JD
authors.lastname: Kasprzak
authors.forename: Magdalena
authors.initials: M
authors.lastname: Chmiela
authors.forename: Maria
authors.initials: M
authors.lastname: Krzemińska-Pakuła
authors.forename: Wiesława
authors.initials: W
authors.lastname: Rudnicka
mesh_terms: D000328:Adult; D000789:Angina, Unstable / Q000276:immunology* / Q000382:microbiology; D000907:Antibodies, Bacterial / Q000097:blood*; D003324:Coronary Artery Disease / Q000209:etiology; D004415:Dyspepsia / Q000276:immunology* / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G