title: Smoking-Related Research in the Asian-Pacific Countries.
abstract: In addition to the obvious link between tobacco consumption and cancer of the lung and oral cavity, there is increasing evidence that carcinogens in smoke many also have an impact in many other organ sites. The potential damage of second hand smoke, especially to children, also requires stress. While studies of gene polymorphisms for enzymes involved in carcinogen metabolism have pointed to a genetic background to smoking likelihood and clearly increased risk of cancer development in many organs for smokers with decreased detoxification potential, the question of how to make best use of this information for practical prevention remains largely unexplored. Similarly, the fact of peer group and family influence in determining initiation of adolescent smoking has yet to be translated into a concrete strategy based on psychological understanding. Cessation programs for adult smokers on the other hand could make use of positive results from interventions in hospital settings, possibly married to screening programs for early cancers. Political and socioeconomic questions are clearly very important and putting into action principles of tobacco control efforts with collaboration between all of the interested parties must now be stressed. Government can play a very positive role by control of sales and marketing, heavy taxation and smoking bans, and provision of funding for research and community interventions, while education and awareness are natural targets of NGOs. The academic research community can perhaps best contribute by further clarifying mechanisms underlying tobacco-related disease, possibly with an emphasis on chemoprevention in association with epidemiological assessment of confounding factors, and also very importantly the psychosociology of the tobacco habit.
authors.affiliation: Chemotherapy and Experimental Pathology Division, National Cancer Center Research Institute, Tokyo, 104-0045, Japan. malcolm812@yahoo.com
authors.forename: Malcolm A
authors.initials: MA
authors.lastname: Moore
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsuda