title: Tome-1, wee1, and the onset of mitosis: coupled destruction for timely entry.
abstract: In a recent issue of Cell, Ayad et al. (2003) report the identification of a novel F box protein Tome-1, which mediates the destruction of mitosis-inhibitory kinase wee1 via E3 ligase SCF. Tome-1 itself is targeted for degradation by APC in G1. This synergy of destructive action by APC and SCF has important implications for timely entry into mitosis.
authors.affiliation: Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Republic of Singapore.
authors.forename: Hong Hwa
authors.initials: HH
authors.lastname: Lim
authors.forename: Uttam
authors.initials: U
authors.lastname: Surana
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D016203:CDC2 Protein Kinase / Q000235:genetics / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D019926:Cyclin B / Q000235:genetics / Q000378:metabolism; D005057:Eukaryotic Cells / Q000201:enzymology*; D006801:Humans; D008025:Ligases / Q000235:genetics / Q000378:metabolism; D008938:Mitosis / Q000235:genetics*; D009687:Nuclear Proteins; D010453:Peptide Synthases / Q000235:genetics / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D044843:SKP Cullin F-Box Protein Ligases; D029702:Schizosaccharomyces pombe Proteins; D043743:Ubiquitin-Protein Ligase Complexes
chemical_list: C473796:CDCA3 protein, human; D018797:Cell Cycle Proteins; D019926:Cyclin B; D009687:Nuclear Proteins; D029702:Schizosaccharomyces pombe Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D044843:SKP Cullin F-Box Protein Ligases; C068689:wee1 protein, S pombe; D011505:Protein-Tyrosine Kinases; C499349:WEE1 protein, human; D016203:CDC2 Protein Kinase; D008025:Ligases; D010453:Peptide Synthases