Synthesis of 3-alkoxycarbonyl-1beta-methylcarbapenem by using the palladium-catalyzed C-N bond-forming reaction between vinyl halide and beta-lactam nitrogen.
3-alkoxycarbonyl-1beta-methylcarbapenem could be synthesized by using a palladium-catalyzed C-N bond-forming reaction between vinyl halide and beta-lactam nitrogen. In this reaction, the use of Pd(OAc)(2) and DPEphos gave a good result, and the generation of Pd(0) from Pd(OAc)(2) in the absence of a base is necessary to increase the yield.
Kozawa
Yuji
Y
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Mori
Miwako
M