title: [Pituitary stalk metastasis from lung cancer, preceding diabetes insipidus--case report and clinical review of the literature].
abstract: A 59-year-old woman whose first clinical manifestations were polyuria and polydipsia was admitted to our hospital. Brain MRI showed multiple mass lesions and a thickened pituitary stalk. Chest CT showed hilar and mediastinal lymphadenopathy and a small nodule measuring about 1.5 cm in the apex of the right lung. Histopathological examination revealed adenocarcinoma of the lung, and primary lung cancer with diabetes insipidus secondary to pituitary stalk metastasis was diagnosed. She received systemic chemotherapy and whole-brain irradiation concurrent with intranasal desmopressin (DDAVP) treatment. Although the size of the tumor was reduced, her symptoms did not improve and the same dose of hormone replacement therapy was required. We present this rare case and review the twenty cases of metastatic pituitary lesions arising from lung cancer reported in the literature.
authors.affiliation: Division of Respiratory Disease, Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Kato
authors.forename: Ryuji
authors.initials: R
authors.lastname: Ieki
authors.forename: Emi
authors.initials: E
authors.lastname: Hashimoto
authors.forename: Erika
authors.initials: E
authors.lastname: Saito
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ota
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yuasa
authors.forename: Mari
authors.initials: M
authors.lastname: Iguchi
authors.forename: Tatsuru
authors.initials: T
authors.lastname: Okamura
authors.forename: Masahiko
authors.initials: M
authors.lastname: Shibuya
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D020790:Diabetes Insipidus, Neurogenic / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy