title: Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis.
abstract: The cysteine proteinases CPA and CPB from Leishmania major induced Th1 responses in patients with leishmaniasis due to Leishmania guyanensis. Furthermore, cysteine proteinases induced neither interleukin 4 (IL-4) nor IL-13 and low levels of IL-10 in controls and patients. The results suggest that CPs would be quite good candidates for a vaccine against different Leishmania species.
authors.affiliation: Immunologie des Leishmanioses, Institut Pasteur de le Guyane Française, Institut d'Etudes Supérieures de la Guyane, Université Antilles-Guyane, Cayenne, French Guiana.
authors.forename: Hervé
authors.initials: H
authors.lastname: Pascalis
authors.forename: Anne
authors.initials: A
authors.lastname: Lavergne
authors.forename: Eliane
authors.initials: E
authors.lastname: Bourreau
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Prévot-Linguet
authors.forename: Amina
authors.initials: A
authors.lastname: Kariminia
authors.forename: Roger
authors.initials: R
authors.lastname: Pradinaud
authors.forename: Sima
authors.initials: S
authors.lastname: Rafati
authors.forename: Pascal
authors.initials: P
authors.lastname: Launois
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan; D001483:Base Sequence; D003546:Cysteine Endopeptidases / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D018334:Leishmania guyanensis / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000276:immunology*; D008969:Molecular Sequence Data; D015800:Protozoan Proteins / Q000276:immunology*; D016052:Protozoan Vaccines / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology*
chemical_list: D000953:Antigens, Protozoan; D007376:Interleukin-2; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; C093139:LACK antigen, Leishmania; D015847:Interleukin-4; D007371:Interferon-gamma; D003546:Cysteine Endopeptidases