Investigation of ethyl alcohol and beta-carotene effect on two models of carcinogenesis.
The effects of ethyl alcohol and synthetic beta-carotene have been studied on two models of carcinogenesis in mice BALB/c. Lung tumours were induced with organotropically acting urethane (given by i.p. injections, total dose--100 mg/mouse) subcutaneous tumours were induced with locally acting benzo(a)pyrene (single injection, 2 mg/mouse) beta-Carotene was given 3 times per week 0.4 mg/mouse by gastric intubations and 10% ethanol was given instead of drinking water until the end of experiments (4-6 months). Results showed that beta-carotene did not significantly inhibit lung adenomogenesis and may moderately delay subcutaneous tumours occurence. In ourstudies chronic ethanol intake did notshow significant influence on this delay.
Uleckiene
Saule
S
Oncology Institute of Vilnius University, LT 2007, Vilnius, Lithuania.
Domkiene
Vida
V
D000818:Animals; D001564:Benzo(a)pyrene; D002273:Carcinogens; D000431:Ethanol / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology; D014520:Urethane / Q000633:toxicity; D019207:beta Carotene / Q000494:pharmacology*
D002273:Carcinogens; D019207:beta Carotene; D001564:Benzo(a)pyrene; D014520:Urethane; D000431:Ethanol