Is mannitol safe for patients with intracerebral hemorrhages? Renal considerations.
OBJECTIVE
Mannitol, a drug widely used to decrease intracranial pressure, can cause renal failure. The goal of this study is to determine the renal safety of mannitol therapy in patients with intraparenchymal hemorrhages.


METHODS
51 patients with intracerebral hemorrhages were treated with mannitol according to guideline of American Heart Association. Serum urea and creatinine levels were measured before mannitol administration and on the 2nd, 5th and 14th day.


RESULTS
Transient elevation of urea and creatinine concentration was noticed, however, none of patients developed anuria or oliguria.


CONCLUSIONS
Our study points out safety of mannitol therapy under control of osmolality, although control of urea and creatinine concentrations in special group of patients (persons with history of renal failure or diabetes) should be considered.
Dziedzic
Tomasz
T
Department of Neurology, Stroke Unit, Jagiellonian University, 31-503 Kraków, ul. Botaniczna 3, Poland. dziedzictom@mediclub.pl
Szczudlik
Andrzej
A
Klimkowicz
Aleksandra
A
Rog
Teresa M
TM
Slowik
Agnieszka
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000188:drug therapy*; D003404:Creatinine / Q000032:analysis; D004234:Diuretics, Osmotic / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D008353:Mannitol / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000139:chemically induced*; D012307:Risk Factors; D014508:Urea / Q000032:analysis
D004234:Diuretics, Osmotic; D008353:Mannitol; D014508:Urea; D003404:Creatinine