[A case of Fahr's disease presenting "diffuse neurofibrillary tangles with calcification"].
77-year-old woman presented memory disturbance, hallucination, and personality change since the summer of 1988. Laboratory findings revealed normal serum Ca, P, HS-PTH levels and Ellsworth-Howard test was intact. Neuroradiological studies disclosed calcification in the dentate nucleus, putamen, globus pallidus and thalamus. We made a diagnosis of Fahr's disease. During the follow-up period of 13 years, brain MRI showed gradual atrophy in temporal lobes. This case was characterized by the clinical and neuroradiological findings of "diffuse neurofibrillary tangles with calcification: DNTC". We discussed the relations of Fahr's disease and DNTC in the literatures. From our long time observation of this case, we suggest that Fahr's disease includes DNTC.
Nomoto
Nobuatsu
N
Fourth Department of Internal Medicine, Toho University School of Medicine.
Sugimoto
Hideki
H
Iguchi
Hiroaki
H
Kurihara
Teruyuki
T
Wakata
Nobuo
N
D000368:Aged; D001284:Atrophy; D001480:Basal Ganglia Diseases / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002114:Calcinosis / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D016874:Neurofibrillary Tangles / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology; D013997:Time Factors