Spectrum of hemostatic derangements, in Budd-Chiari syndrome.
BACKGROUND
Hemostatic abnormalities have been reported in various hepatocellular diseases. We evaluated the hemostatic functions in patients with Budd-Chiari syndrome.


METHODS
Biochemical liver function tests, and measurement of prothrombin time, activated partial thromboplastin time, and plasma levels of anti-thrombin III (antigen) and activity of protein C were done in 36 patients with Budd-Chiari syndrome.


RESULTS
Liver biochemistry was abnormal in 34 patients. Plasma prothrombin time and activated partial thromboplastin time were prolonged in 17 (47%) and 23 (64%) patients, respectively. Antithrombin III antigen levels and protein C activity were reduced in 15 (50%) and 25 (83%) patients, respectively, among the 30 patients studied. Albumin levels showed significant correlation with coagulation test results, levels of anti-thrombin-III, and protein C activity.


CONCLUSIONS
Hepatic synthesis of coagulation factors and anticoagulants is reduced in Budd-Chiari syndrome; this may play a role in recurrence of thrombosis.
Pati
Hara Prasad
HP
Department of Hematology, All India Institute of Medical Sciences, New Delhi 110 029. harappati@yahoo.com
Dayal
Sanjana
S
Srivastava
Amita
A
Pande
Girish Kumar
GK
Acharya
Subrat Kumar
SK
D006502:Budd-Chiari Syndrome / Q000097:blood*; D005260:Female; D006487:Hemostasis; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D010314:Partial Thromboplastin Time