title: Tensile properties, tension-tension fatigue and biological response of polyetheretherketone-hydroxyapatite composites for load-bearing orthopedic implants.
abstract: Polyetheretherketone-hydroxyapatite composites were developed as alternative materials for load-bearing orthopedic applications. The amount of hydroxyapatite (HA) incorporated into the polyetheretherketone (PEEK) polymer matrix ranges from 5 to 40 vol% and these materials were successfully fabricated by injection molding. This study presents the mechanical and biological behavior of the composite materials developed. It was found that the amount of HA in the composite influenced the tensile properties. Dynamic behavior under tension-tension fatigue revealed that the fatigue-life of PEEK-HA composites were dependent on the HA content as well as the applied load. The biological responses of PEEK-HA composites carried out in vivo verified the biocompatibility and bioactive nature of the composite materials.
authors.affiliation: Biomedical Engineering Research Center, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore.
authors.forename: M S
authors.initials: MS
authors.lastname: Abu Bakar
authors.forename: M H W
authors.initials: MH
authors.lastname: Cheng
authors.forename: S M
authors.initials: SM
authors.lastname: Tang
authors.forename: S C
authors.initials: SC
authors.lastname: Yu
authors.forename: K
authors.initials: K
authors.lastname: Liao
authors.forename: C T
authors.initials: CT
authors.lastname: Tan
authors.forename: K A
authors.initials: KA
authors.lastname: Khor
authors.forename: P
authors.initials: P
authors.lastname: Cheang
mesh_terms: D000818:Animals; D001577:Benzophenones; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D004548:Elasticity; D005269:Femur / Q000166:cytology / Q000648:ultrastructure; D007595:Joint Prosthesis; D007659:Ketones / Q000737:chemistry*; D008420:Manufactured Materials; D008422:Materials Testing; D009983:Orthopedic Equipment; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers; D013314:Stress, Mechanical; D013499:Surface Properties; D013552:Swine; D013718:Tensile Strength; D016474:Weight-Bearing / Q000502:physiology*
chemical_list: D001577:Benzophenones; D001672:Biocompatible Materials; D018786:Bone Substitutes; D007659:Ketones; D011108:Polymers; C063834:polyetheretherketone; D011092:Polyethylene Glycols; D017886:Durapatite