title: Biological factors and therapeutic modulation in prostate cancer radiotherapy.
abstract: Biologic factors affect the ability of radiation to effectively treat all patients with prostate cancer. The use of prognostic and genetic markers (12 lipoxygenase, p53, bc1-2 genes, ploidy) may aid in the development of treatments for these patients. Particularly, several studies have shown that p53 tumor suppressor gene mutations are infrequent in prostate cancer and are associated with advanced disease. Recent efforts have been directed toward novel therapeutic modalities, especially in combination with standard irradiation of prostate carcinoma. These modalities are based on an improved knowledge of these biological factors involved in the progression and diffusion of the tumor, especially p53. Several authors evaluated the predictive and prognostic role of p53 in patients with prostatic cancer treated with radiotherapy. An extensive review of international reports on the subject is provided.
authors.affiliation: Cattedra di Radioterapia, Istituto di Radiologia, Università Cattolica del S. Cuore, Policlinico A. Gemelli, Largo A. Gemelli, 8, 00168 Roma, Italy. ncellini@rm.unicatt.it
authors.forename: Numa
authors.initials: N
authors.lastname: Cellini
authors.forename: Stefano
authors.initials: S
authors.lastname: Luzi
authors.forename: Alessio G
authors.initials: AG
authors.lastname: Morganit
authors.forename: Daniela
authors.initials: D
authors.lastname: Smaniotto
authors.forename: Gian Carlo
authors.initials: GC
authors.lastname: Mattiucci
authors.forename: Cinzia
authors.initials: C
authors.lastname: Digesù
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Mangiacotti
authors.forename: Francesco
authors.initials: F
authors.lastname: Cellini
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Valentini
mesh_terms: D001685:Biological Factors; D014408:Biomarkers, Tumor; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D016159:Tumor Suppressor Protein p53
chemical_list: D001685:Biological Factors; D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53