An effective one-pot synthesis of 5-substituted tetronic acids.
An expeditious one-pot synthesis of 5-substituted tetronic acids from aldehydes and terminal conjugated alkyne as starting materials is described. The entire process embodies two consecutive chemical events: a catalytic domino reaction to build the 1,3-dioxolane scaffolds 5 and a two-step acid-catalyzed trans-acetalization-lactonization reaction to furnish the tetronic acid derivatives 6.
Aragón
David Tejedor
DT
Instituto de Productos Naturales y Agrobiología, CSIC, Avda. Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.
López
Gloria V
GV
García-Tellado
Fernando
F
Marrero-Tellado
José Juan
JJ
de Armas
Pedro
P
Terrero
David
D