title: Relapsing ulcerative papules over bilateral hands and scrotum in an Asian man: an atypical manifestation of primary cutaneous CD30-positive lymphoma.
abstract: A 33-year-old Taiwanese man presented at our clinic with multiple erythematous ulcerated papules over his bilateral hands. CD30-positive anaplastic large cell lymphoma (CD30+ ALCL) was diagnosed by an incisional biopsy. After a thorough survey for extracutaneous involvement, the diagnosis of primary cutaneous CD30+ ALCL was established. Due to spontaneous regression of some skin lesions, the patient refused therapeutic intervention. Subsequently, an ulcerative nodule arose over the scrotum. It spontaneously regressed 5 weeks later. Although histologically alarming, this particular lymphoma bears favorable prognosis. Thus, recognition of this entity is of great importance, because it may prevent patients from undergoing unnecessary aggressive treatment. To our knowledge, CD30+ ALCL has not been reported to evolve in the pattern similar as observed in our patient. Thus, this Asian man presents a rare presentation of CD30+ ALCL.
authors.affiliation: Department of Dermatology, Kaohsiung Medical University, Taiwan.
authors.forename: Cheng-Che E
authors.initials: CC
authors.lastname: Lan
authors.forename: Hsin-Su
authors.initials: HS
authors.lastname: Yu
authors.forename: Shih-Tsung
authors.initials: ST
authors.lastname: Cheng
authors.forename: Gwo-Shing
authors.initials: GS
authors.lastname: Chen
mesh_terms: D000328:Adult; D044466:Asian People; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006229:Hand Dermatoses / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis / Q000276:immunology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D012075:Remission, Spontaneous; D018570:Risk Assessment; D012883:Skin Ulcer / Q000175:diagnosis / Q000473:pathology*; D013624:Taiwan; D016312:Treatment Refusal
chemical_list: D017730:Ki-1 Antigen