title: [A case of multicentric Castleman's disease with pulmonary involvement].
abstract: In a man aged 34 who had been experiencing frequent coughing since November 2001, a chest radiograph showed infiltration shadows in both lung fields. Chest CT showed diffuse centrilobular nodules and multiple mediastinal lymphadenopathy. Laboratory examination revealed high values for C-reactive protein and the erythrocyte sedimentation rate, together with polyclonal hyperimmunoglobulinemia and an elevated interleukin-6 level. We suspected multicentric Castleman's disease, and so performed thoracoscopic mediastinal lymph node biopsy and lung biopsy. The former disclosed follicular hyperplasia and plasma cell infiltration in the interfollicular area, suggesting a diagnosis of Castleman's disease, plasma cell type. The lung biopsy showed heavy infiltration of plasma cells. The diagnosis was therefore multicentric Castleman's disease (MCD) with pulmonary involvement. The chest CT findings were tpical characteristics of pulmonary involvement in patients with MCD.
authors.affiliation: Department of Internal Medicine, Tokai Central Hospital, 4-6-2 Sohara-Higashijima, Kakamigahara-city, Gifu 504-0816, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Morise
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimomoto
authors.forename: Toyohiro
authors.initials: T
authors.lastname: Honda
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Mori
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005871:Castleman Disease / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D002772:Cholera Toxin; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008482:Mediastinum; D011020:Pneumonia, Pneumocystis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D011859:Radiography
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D002772:Cholera Toxin