title: Hyperpigmentation mimicking Laugier syndrome, levodopa therapy and Addison's disease.
abstract: The Laugier-Hunziker syndrome is an acquired, idiopathic, benign mucocutaneous hypermelanosis that usually occurs on the lips and oral mucosa, although it may appear at other sites. Nails are frequently involved, mainly forming longitudinal hyperpigmented bands. We report the case of a patient that presented a typical picture of this entity, nearly 1 year after the beginning of treatment with levodopa. Two years after the first lesions occurred, she developed Addison's disease. The patient suffered from a diffuse discrete hyperpigmentation (it was more remarkable on exposed areas) and an intensification of the melanotic macules that were previously noticeable before in oral and genital mucosa, fingers, toes and nails. Hormonal replacement treatment enabled the control of laboratory and general manifestations and to decrease the degree of mucocutaneous hyperpigmentation considerably, despite initial hyperpigmented lesions persisting in described areas.
authors.affiliation: Department of Dermatology, University of Valladolid, Hospital Clinico Universitario, Avenida Ramón y Cajal, Valladolid 47005, Spain. jvegagu@medynet.com
authors.forename: J
authors.initials: J
authors.lastname: Vega Gutiérrez
authors.forename: A
authors.initials: A
authors.lastname: Miranda Romero
authors.forename: G
authors.initials: G
authors.lastname: Martínez
authors.forename: M V
authors.initials: MV
authors.lastname: Torrero
authors.forename: M
authors.initials: M
authors.lastname: López de Juan
mesh_terms: D000224:Addison Disease; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005438:Fludrocortisone / Q000627:therapeutic use; D005533:Foot Dermatoses / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D006229:Hand Dermatoses / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D017495:Hyperpigmentation / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D007980:Levodopa / Q000008:administration & dosage / Q000627:therapeutic use*; D009061:Mouth Mucosa; D010300:Parkinson Disease / Q000188:drug therapy; D013577:Syndrome; D014844:Vulva
chemical_list: D007980:Levodopa; D005438:Fludrocortisone; D006854:Hydrocortisone