[Mechanism of injury by active oxygen radical to hemoglobin].
The injury effects of O2-. and H2O2 on the hemoglobin were investigated. The results showed that the metal prosthetic group was injured by O2-. and H2O2, but the mechanism of O2-. and H2O2 effects was different. Through the charge neutralization O2-. destroying the static electrical interactions between prosthethic groups and amino acid residues, it thereby caused prosthetic group dropped. H2O2 had Fenton reaction with Fe2+ in prosthetic group, hence produced .OH. It can destroy the porphyrin structure at fixed point in short distance, so the prosthetic group was destroyed and non-reversible.
Dai
Y
Y
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Chang
P
P
Li
G
G
Lin
Y
Y
D006454:Hemoglobins / Q000032:analysis / Q000187:drug effects*; D006801:Humans; D017382:Reactive Oxygen Species / Q000633:toxicity*; D013481:Superoxides / Q000633:toxicity*
D006454:Hemoglobins; D017382:Reactive Oxygen Species; D013481:Superoxides