title: Adenocarcinoma of the female urethral diverticulum treated by multimodality therapy.
abstract: A 75-year-old female presented with a 7-month history of intermittent macrohematuria and urinary retention. Physical examination revealed a firm, round mass on the anterior vaginal wall. The diagnosis by urethroscopy and radiological evaluation was localized urethral diverticular tumor. Pathological examination of the biopsy specimen revealed adenocarcinoma. The patient received two courses of intra-arterial and systemic chemotherapy using cisplatin, 5-fluorouracil and leucovorin, followed by radiation to the urethra. The tumor shrunk markedly after chemotherapy. The patient underwent total urethrectomy and vesicostomy. Two years after the operation, she had no evidence of recurrence. Adenocarcinoma of the female urethral diverticulum is rare and has been treated by surgery and/or radiation. The present case is the first case of it being treated by multimodality therapy including chemotherapy.
authors.affiliation: Department of Urology, Kyoto National Hospital, Kyoto, Japan. yawakura@yahoo.com
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Awakura
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Nonomura
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Itoh
authors.forename: Atsushi
authors.initials: A
authors.lastname: Maeno
authors.forename: Takuo
authors.initials: T
authors.lastname: Fukuyama
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000628:therapy*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D004240:Diverticulum / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D014523:Urethral Neoplasms / Q000175:diagnosis / Q000628:therapy*
chemical_list: D002945:Cisplatin; D002955:Leucovorin; D005472:Fluorouracil