Seeking SOCS and sex steroids.
In seeking to explain why oral estrogen inhibits the GH-IGF-I axis, a recent study has unearthed a new way that steroid hormones can influence growth hormone action. This involves suppressors of cytokine signalling (SOCS), which offer a new level of understanding in signal control and crosstalk.
Waters
Michael J
MJ
Institute for Molecular Bioscience and School of Biomedical Sciences, University of Queensland, St Lucia 4072, Australia. m.waters@mailbox.uq.edu.au
D000284:Administration, Oral; D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D004268:DNA-Binding Proteins; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism*; D020249:Hormone Replacement Therapy; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D012097:Repressor Proteins; D015398:Signal Transduction; D050826:Suppressor of Cytokine Signaling Proteins; D015534:Trans-Activators
D016207:Cytokines; D004268:DNA-Binding Proteins; D004967:Estrogens; D012739:Gonadal Steroid Hormones; D011506:Proteins; D012097:Repressor Proteins; C106643:SOCS2 protein, human; D050826:Suppressor of Cytokine Signaling Proteins; D015534:Trans-Activators; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone