Pyridine-sugar conjugates as potent inhibitors of enzyme-catalysed glycoside hydrolysis.
A series of O- and N-linked pseudo-disaccharides incorporating simple functionalised pyridines were synthesized and demonstrated potent inhibition of the glucoamylase-catalysed reaction.
Nkansah
Peter A
PA
School of Chemical Sciences, University of East Anglia, Norwich, UK NR4 7TJ.
Haines
Alan H
AH
Stamford
N Patrick J
NP
D002384:Catalysis; D004187:Disaccharides / Q000737:chemistry* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D005087:Glucan 1,4-alpha-Glucosidase / Q000037:antagonists & inhibitors*; D006868:Hydrolysis; D007700:Kinetics; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*
D004187:Disaccharides; D004791:Enzyme Inhibitors; D011725:Pyridines; D005087:Glucan 1,4-alpha-Glucosidase