Haemoglobin Marseille-Long Island and interpretation of HbA1c: which HbA1c result is the "right answer"?
A woman was screened for diabetes using glycated haemoglobin (HbA1c). Vastly different results were obtained by high performance liquid chromatography (45%), immunoassay (2.9%), and affinity chromatography (4.2%) compared with the non-diabetic range of less than 6.4%. Mass spectral studies confirmed the presence a haemoglobin variant, haemoglobin Marseille-Long Island which had confounded interpretation by all methods.
Florkowski
C M
CM
Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand. chris.florkowski@cdhb.govt.nz
Walmsley
T A
TA
Brennan
S O
SO
George
P M
PM
D000328:Adult; D002846:Chromatography, Affinity / Q000592:standards; D002851:Chromatography, High Pressure Liquid / Q000592:standards; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D013058:Mass Spectrometry / Q000592:standards; D012680:Sensitivity and Specificity
D006442:Glycated Hemoglobin