title: Dependence of normal development of skeletal muscle in neonatal rats on load bearing.
abstract: Antigravity function plays an important role in determining the morphological and physiological properties of the neuromuscular system. Inhibition of the normal development of the neuromuscular system is induced by hindlimb unloading during the neonatal period in rats. However, the role of gravitational loading on the development of skeletal muscle in rats is not well understood. It could be hypothesized that during the early postnatal period, i.e. when minimal weight-supporting activity occurs, the activity imposed by gravity would be of little consequence in directing the normal development of the skeletal musculature. We have addressed this issue by limiting the amount of postnatal weight-support activity of the hindlimbs of rats during the lactation period. We have focused on the development of three characteristics of the muscle fibers, i.e. size, myonuclear number and myosin heavy chain expression.
authors.affiliation: Dept. Physiol. Biomech., NIFS, Kanoya, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohira
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Yoshinaga
authors.forename: F
authors.initials: F
authors.lastname: Kawano
authors.forename: T
authors.initials: T
authors.lastname: Nomura
authors.forename: I
authors.initials: I
authors.lastname: Nonaka
authors.forename: D L
authors.initials: DL
authors.lastname: Allen
authors.forename: R R
authors.initials: RR
authors.lastname: Roy
authors.forename: V R
authors.initials: VR
authors.lastname: Edgerton
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D001835:Body Weight; D019417:Hindlimb Suspension; D018656:Muscle Fibers, Fast-Twitch / Q000473:pathology / Q000502:physiology*; D018657:Muscle Fibers, Slow-Twitch / Q000473:pathology / Q000502:physiology*; D018482:Muscle, Skeletal / Q000254:growth & development* / Q000473:pathology / Q000502:physiology; D018995:Myosin Heavy Chains / Q000378:metabolism; D009218:Myosins / Q000378:metabolism; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D016474:Weight-Bearing
chemical_list: D018995:Myosin Heavy Chains; D009218:Myosins