title: Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses.
abstract: OBJECTIVE
  Recent epidemiological work suggests an association between periodontal disease severity and cardiovascular disease risk. This study aimed to ascertain if circulating levels of cardiovascular and systemic inflammatory markers could be modified following treatment of periodontal disease.
  
  
  METHODS
  Adult subjects were recruited from those awaiting periodontal treatment and randomised to either immediate (test, n=24) or delayed treatment (control, n=15). Demographic and clinical data were collected and venous blood was taken before and either 6 weeks after completion of treatment or after an equivalent 3-month control period. Periodontal examination included probing depth, loss of attachment, plaque scores and bleeding scores. Blood was analysed to determine serum and plasma fibrinogen, C-reactive protein, sialic acid, tumour necrosis factor-alpha and interleukin -6 and -1beta. Effects of treatment were assessed by paired tests and analysis of variance by treatment group with baseline covariates.
  
  
  RESULTS
  Treatment improved plaque and bleeding scores and reduced probing depths (p<0.002). However, there were no statistically significant changes in levels of any of the systemic markers.
  
  
  CONCLUSIONS
  Improvement in periodontal health did not influence the levels of vascular markers.
authors.affiliation: Department of Periodontology and Preventive Dentistry, Guy's, King's and St. Thomas' School of Biomedical Science, King's College London, Guys Tower, St. Thomas' Street, London SE1 9RT, UK. mark.ide@kcl.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Ide
authors.forename: D
authors.initials: D
authors.lastname: McPartlin
authors.forename: P Y
authors.initials: PY
authors.lastname: Coward
authors.forename: M
authors.initials: M
authors.lastname: Crook
authors.forename: P
authors.initials: P
authors.lastname: Lumb
authors.forename: R F
authors.initials: RF
authors.lastname: Wilson
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002908:Chronic Disease; D015331:Cohort Studies; D003774:Dental Plaque Index; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid / Q000097:blood; D017622:Periodontal Attachment Loss / Q000097:blood / Q000628:therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000097:blood / Q000628:therapy; D010518:Periodontitis / Q000097:blood / Q000628:therapy*; D011446:Prospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D018836:Inflammation Mediators; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D005340:Fibrinogen; D002097:C-Reactive Protein; D019158:N-Acetylneuraminic Acid