title: Molecular characterization of the porcine gene CAPNS1 encoding the small subunit 1 of calpain on SSC6q1.1-->q1.2.
abstract: The CAPNS1 gene encodes the small subunit of the calpain proteases. Cloning and characterization of the porcine CAPNS1 gene revealed a highly conserved organization with respect to other mammalian CAPNS1 orthologs. The porcine gene consists of 11 exons spanning approximately 7.3 kb and codes for a peptide of 266 amino acids. Analysis of the naturally occurring variation of the CAPNS1 gene in different pig breeds revealed six SNPs and four small insertion/deletion polymorphisms. The CAPNS1 gene is located immediately adjacent to the COX7A1 gene on SSC6q1.1-->q1.2.
authors.affiliation: Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Hannover, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Drögemüller
authors.forename: T
authors.initials: T
authors.lastname: Leeb
mesh_terms: D000818:Animals; D001483:Base Sequence; D002154:Calpain / Q000235:genetics*; D033481:Chromosomes, Mammalian; D040461:Gene Components; D011110:Polymorphism, Genetic; D021122:Protein Subunits; D022821:RNA Splice Sites; D013552:Swine / Q000235:genetics*
chemical_list: D021122:Protein Subunits; D022821:RNA Splice Sites; D002154:Calpain