title: Relationship of Kaposi sarcoma (KS)-associated herpesvirus viremia and KS disease in Zimbabwe.
abstract: The relationship between Kaposi sarcoma-associated herpesvirus (KSHV) viremia and KS disease was investigated in 500 subjects who received treatment in Harare, Zimbabwe. Subjects were grouped by results of human immunodeficiency virus (HIV) type 1 serological tests, KS diagnosis, and KS clinical stage. The plasma KSHV DNA concentration was associated with concomitant KS and HIV-1 infection (AIDS-KS; P<.001) and AIDS-KS clinical stage (P=.01). Plasma KSHV DNA levels were greater in AIDS-KS than in matched HIV-1-seronegative KS (P=.04). The plasma KSHV DNA level was not associated with age, sex, systemic symptoms, or CD4+ lymphocyte count. Plasma and peripheral blood mononuclear cell KSHV DNA concentrations were linearly related (r2=.44; P<.001), and the nucleotide sequence of the K1 gene highly variable region was identical in both compartments. These findings provide evidence that KSHV viremia is common in advanced AIDS-KS in Zimbabwe and suggest a relationship between KSHV lytic replication and untreated HIV-1 infection.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Campbell
authors.forename: Margaret
authors.initials: M
authors.lastname: Borok
authors.forename: Irene E
authors.initials: IE
authors.lastname: White
authors.forename: Ivy
authors.initials: I
authors.lastname: Gudza
authors.forename: Buxton
authors.initials: B
authors.lastname: Ndemera
authors.forename: Albert
authors.initials: A
authors.lastname: Taziwa
authors.forename: Adriana
authors.initials: A
authors.lastname: Weinberg
authors.forename: Lovemore
authors.initials: L
authors.lastname: Gwanzura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000032:analysis; D019353:Endemic Diseases; D005260:Female; D014644:Genetic Variation; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000097:blood / Q000150:complications*; D014766:Viremia / Q000097:blood / Q000150:complications*; D015030:Zimbabwe / Q000453:epidemiology
chemical_list: D004279:DNA, Viral