A longitudinal study of short- and long-term activity levels in male and female spontaneously hypertensive, Wistar-Kyoto, and Sprague-Dawley rats.
The pattern of locomotor activity across development was assessed in male and female spontaneously hypertensive (SHR), Wistar-Kyoto (WKY), and Sprague-Dawley (SD) rats. Open field activity did not indicate hyperactivity in the SHR. Instead, the SD strain was generally more active. Strains and sexes did not differ in open-field locomotor response to drug challenges. When short-term (10-12 min) activity in different apparatuses was compared, the SD were most active in the open field, the SHR in the residential figure-eight maze, and the WKY in the running wheel. Long-term tests indicated hyperactivity in the SHR in the residential figure-eight maze and hypoactivity in the SD in the running wheels. Until such strain differences in activity are thoroughly defined, the use of the SHR as a model of attention-deficit/ hyperactivity disorder is limited.
Ferguson
Sherry A
SA
Division of Neurotoxicology, Jefferson, National Center for Toxicological Research, U.S. Food and Drug Administration, Arkansas 72079, USA. sferguson@nctr.fda.gov
Cada
Amy M
AM
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004924:Escape Reaction; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D008137:Longitudinal Studies; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D008774:Methylphenidate / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D011247:Pregnancy; D011603:Psychophysiology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D013045:Species Specificity
D000697:Central Nervous System Stimulants; D008774:Methylphenidate