Anti-inflammatory and analgesic effects of a mixture of fatty acids isolated and purified from sugar cane wax oil.
The anti-inflammatory and analgesic effects of FAM, a defined mixture of fatty acids isolated from sugar cane (Saccharum officinarum L.), was evaluated. Oral administration of this mixture showed anti-inflammatory activity in the cotton pellet granuloma assay and in the carrageenin-induced pleurisy test, both in rats, as well as in the peritoneal capillary permeability test in mice. In addition, FAM showed analgesic properties in the hot-plate model and in the acetic acid-induced writhings test, both in mice. In conclusion, these results provide evidence on the potential usefulness of the mixture of fatty acids from sugar cane wax oil in inflammatory disorders.
Ledón
N
N
Casacó
A
A
Rodríguez
V
V
Cruz
J
J
González
R
R
Tolón
Z
Z
Cano
M
M
Rojas
E
E
D019342:Acetic Acid; D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D005227:Fatty Acids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D015745:Granuloma, Foreign-Body / Q000517:prevention & control; D006358:Hot Temperature; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010998:Pleurisy / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D031786:Saccharum
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005227:Fatty Acids; D010936:Plant Extracts; D002351:Carrageenan; D019342:Acetic Acid