title: Genomic expression discovery predicts pathways and opposing functions behind phenotypes.
abstract: Discovering states of genetic expression that are true to a high degree of certainty is likely to predict gene function behind biological phenotypes. The states of expression (up- or down-regulated) of 19200 cDNAs in 10 meningiomas are compared with normal brain by an algorithm that detects only 1 false measurement per 192000; 364 genes are discovered. The expression data accurately predict activation of signaling pathways and link gene function to specific phenotypes. Meningiomas appear to acquire aberrant phenotypes by disturbing the balanced expression of molecules that promote opposing functions. The findings expose interconnected genes and propose a role of genomic expression discovery in functional genomics of living systems.
authors.affiliation: Department of Neurological Sciences and Neurosurgery, Rush Presbyterian-S. Luke's Medical Center, Chicago, Illinois 60612, USA. hfathall@rush.edu
authors.forename: Hassan M
authors.initials: HM
authors.lastname: Fathallah-Shaykh
authors.forename: Bin
authors.initials: B
authors.lastname: He
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Zhao
authors.forename: Herbert H
authors.initials: HH
authors.lastname: Engelhard
authors.forename: Leonard
authors.initials: L
authors.lastname: Cerullo
authors.forename: Terry
authors.initials: T
authors.lastname: Lichtor
authors.forename: Richard
authors.initials: R
authors.lastname: Byrne
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Munoz
authors.forename: Kelvin
authors.initials: K
authors.lastname: Von Roenn
authors.forename: Gail L
authors.initials: GL
authors.lastname: Rosseau
authors.forename: Roberta
authors.initials: R
authors.lastname: Glick
authors.forename: Chen
authors.initials: C
authors.lastname: Sherman
authors.forename: Khan
authors.initials: K
authors.lastname: Farooq
mesh_terms: D000465:Algorithms; D001921:Brain / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D020869:Gene Expression Profiling / Q000379:methods*; D005786:Gene Expression Regulation; D006801:Humans; D008579:Meningioma / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D010641:Phenotype; D012334:RNA, Neoplasm / Q000032:analysis*; D015398:Signal Transduction
chemical_list: D012334:RNA, Neoplasm