[Constituents of the pericarps of Mallotus japonicus (Euphorbiaceae)].
Rottlerin-like phloroglucinol derivatives isolated from the pericarps of Mallotus japonicus Muell. Arg. (Euphorbiaceae) are reviewed. Chemical structures, cytotoxicity, antitumor and antitumor-promoting effects, antiviral activity, anti-HIV-RT activity, and inhibitory activity of activated macrophages (inhibitory activities of NO, prostaglandin E2, tumor necrosis factor-alpha, and interleukin-6 production) of the phloroglucinol derivatives are described.
Arisawa
Munehisa
M
Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan. marisawa@ms.toyama-mpu.ac.jp
D000818:Animals; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D002273:Carcinogens / Q000037:antagonists & inhibitors; D003864:Depression, Chemical; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors; D006801:Humans; D008262:Macrophage Activation / Q000187:drug effects; D036461:Mallotus Plant / Q000737:chemistry*; D010696:Phloroglucinol / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D024301:Plant Bark / Q000737:chemistry*
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D002273:Carcinogens; D004365:Drugs, Chinese Herbal; D010696:Phloroglucinol; D054303:HIV Reverse Transcriptase