Chromosome assignment of eight SOX family genes in chicken.
Chromosome locations of the eight SOX family genes, SOX1, SOX2, SOX3, SOX5, SOX9, SOX10, SOX14 and SOX21, were determined in the chicken by fluorescence in situ hybridization. The SOX1 and SOX21 genes were localized to chicken chromosome 1q3.1-->q3.2, SOX5 to chromosome 1p1.6-->p1.4, SOX10 to chromosome 1p1.6, and SOX3 to chromosome 4p1.2-->p1.1. The SOX2 and SOX14 genes were shown to be linked to chromosome 9 using two-colored FISH and chromosome painting, and the SOX9 gene was assigned to a pair of microchromosomes. These results suggest that these SOX genes form at least three clusters on chicken chromosomes. The seven SOX genes, SOX1, SOX2, SOX3, SOX5, SOX10, SOX14 and SOX21 were localized to chromosome segments with homologies to human chromosomes, indicating that the chromosome locations of SOX family genes are highly conserved between chicken and human.
Kuroiwa
A
A
Laboratory of Animal Cytogenetics, Center for Advanced Science and Technology, Hokkaido University, Sapporo, Japan. asatok@ees.hokudai.ac.jp
Uchikawa
M
M
Kamachi
Y
Y
Kondoh
H
H
Nishida-Umehara
C
C
Masabanda
J
J
Griffin
D K
DK
Matsuda
Y
Y
D000818:Animals; D002645:Chickens / Q000235:genetics*; D002874:Chromosome Mapping; D020223:Chromosome Painting; D033481:Chromosomes, Mammalian; D004268:DNA-Binding Proteins / Q000235:genetics; D024002:HMGB Proteins; D006609:High Mobility Group Proteins / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009363:Neoplasm Proteins / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics; D055758:SOX9 Transcription Factor; D055748:SOXB1 Transcription Factors; D055749:SOXB2 Transcription Factors; D055755:SOXD Transcription Factors; D055757:SOXE Transcription Factors; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; D024002:HMGB Proteins; D006609:High Mobility Group Proteins; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; C490906:SOX1 protein, human; C527923:SOX10 protein, human; C117478:SOX14 protein, human; C527782:SOX2 protein, human; C484488:SOX21 protein, human; C527785:SOX3 protein, human; C490301:SOX5 protein, human; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; D055748:SOXB1 Transcription Factors; D055749:SOXB2 Transcription Factors; D055755:SOXD Transcription Factors; D055757:SOXE Transcription Factors; C527924:Sox10 protein, mouse; C492175:Sox14 protein, mouse; C527783:Sox2 protein, mouse; C484490:Sox21 protein, Gallus gallus; C527786:Sox3 protein, mouse; C527933:Sox9 protein, mouse; D014157:Transcription Factors