Inhibition by Vitamin E of Cholangiocarcinoma Induction due to Combined Nitrite and Aminopyrine.
The present experiment was conducted to assess the influence of vitamin E, given in the diet at 0.5 or 1%, on induction of lesions in the Syrian hamster liver by long term combined administration of sodium nitrite and aminopyrine in the drinking water. Inhibition of both cholangiofibrosis and cholangiocarcinoma development, as well as a reduction in hepatocellular nodules was the result. The underlying mechanisms presumably involve alteration of endogenous dimethylnitrosamine formation by the vitamin, with clear implications for prevention in the human environment.
Thamavit
Witaya
W
Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Pratoomtone
Pakasit
P
Kongtim
Surapol
S
Shirai
Tomoyuki
T
Ito
Nobuyuki
N