title: The effect of quinine on the electroretinograms of children with pediatric cerebral malaria.
abstract: To investigate the effects of quinine on the electroretinograms (ERGs) of children with cerebral malaria (CM), we recruited subjects during a single malaria season in Blantyre, Malawi. Seventy ERG investigations were performed, on 34 children with CM. Time recorded from completion of the most recent quinine infusion was termed "quinine elapsed time" (QET). In a subgroup of 16 children, whole-blood quinine concentrations were estimated in a sample of capillary blood, for validation. A significant positive association was found between QET and both maximal-response A-wave amplitude (MRAWA; P=.03) and cone A-wave amplitude (P=.04). Longitudinal analysis demonstrated a significant trend of increasing MRAWA with increasing QET (P=.03). Parenteral quinine administered in therapeutic doses to a pediatric population appears to cause a transient depression in photoreceptor function. No evidence of ocular quinine toxicity was found at the therapeutic doses used.
authors.affiliation: St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom. jonlochh@AOL.com
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lochhead
authors.forename: Armand
authors.initials: A
authors.lastname: Movaffaghy
authors.forename: Benedetto
authors.initials: B
authors.lastname: Falsini
authors.forename: Peter A
authors.initials: PA
authors.lastname: Winstanley
authors.forename: Edward K
authors.initials: EK
authors.lastname: Mberu
authors.forename: Charles E
authors.initials: CE
authors.lastname: Riva
authors.forename: Malcolm E
authors.initials: ME
authors.lastname: Molyneux
authors.forename: Terrie E
authors.initials: TE
authors.lastname: Taylor
authors.forename: Simon P
authors.initials: SP
authors.lastname: Harding
mesh_terms: D000962:Antimalarials / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D004596:Electroretinography; D005260:Female; D006801:Humans; D016014:Linear Models; D016779:Malaria, Cerebral / Q000150:complications / Q000188:drug therapy*; D008297:Male; D011803:Quinine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology*; D012164:Retinal Diseases / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000962:Antimalarials; D011803:Quinine