title: The clinical relevance of systolic pressure variations in anesthetized nonhypotensive patients.
abstract: OBJECTIVE
  To assess the accuracy of respiratory-induced systolic pressure variation and its components to detect low left ventricular preload.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Sixty-seven patients undergoing major surgery under general anesthesia.
  
  
  METHODS
  Transesophageal echocardiographic measurements during apnea and mechanical ventilation.
  
  
  RESULTS
  Respiratory-induced systolic pressure variation and its components and left ventricular end-diastolic area obtained by transesophageal echocardiography were noted simultaneously. Arterial pressure indices did not allow a reliable diagnosis of a low left ventricular end-diastolic area using a cut-off value of 7.9 cm(2)/m(2) (inferior boundary of the interquartile range of the areas measured in the authors' group).
  
  
  CONCLUSIONS
  These results suggest that systolic pressure variations noticed after induction of general anesthesia do not reflect low left ventricular preload in nonhypotensive patients.
authors.affiliation: Service d'Anesthésie, Hôpital Foch, Suresnes, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dalibon
authors.forename: Thierry
authors.initials: T
authors.lastname: Guenoun
authors.forename: Didier
authors.initials: D
authors.lastname: Journois
authors.forename: Jerôme
authors.initials: J
authors.lastname: Frappier
authors.forename: Denis
authors.initials: D
authors.lastname: Safran
authors.forename: Marc
authors.initials: M
authors.lastname: Fischler
mesh_terms: D000768:Anesthesia, General / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects*; D017548:Echocardiography, Transesophageal; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D020896:Hypovolemia / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012121:Respiration, Artificial; D012680:Sensitivity and Specificity; D013514:Surgical Procedures, Operative; D016277:Ventricular Function, Left / Q000502:physiology