title: Prospective multicenter study with a new implant for thoracolumbar vertebral body replacement.
abstract: BACKGROUND
  There are several therapeutic strategies for restoring the anterior column of the vertebral body after trauma, tumor and infection. We present a multicenter study with a new distractable titanium implant for vertebral body replacement.
  
  
  METHODS
  Prospective documentation was collected of the first 126 patients treated with Synex during the 1st year of the clinical course. There was an evaluation of surgical indication, classification, localisation of the lesion, operative details, complications, and clinical course.
  
  
  RESULTS
  A total of 70 men and 56 women (average age 46.9 years) underwent surgery for vertebral fracture, correction of posttraumatic kyphosis, infection, vertebral tumor and metastasis, and other diseases such as ankylosing spondylitis. Synex was used in open and minimally invasive surgery. In almost every case, an additional anteriorly or posteriorly stabilizing implant was used. Anterior fusion was performed with cement in tumors and autologous bone in fractures. Mono- and multisegmental lesions in the thoracic and lumbar spine were treated.
  
  
  CONCLUSIONS
  The Synex implant is very easy to manage and is suitable for many indications such as vertebral fracture, correction of posttraumatic kyphosis, infection, vertebral tumor/metastasis, and other diseases. The vertebral body replacement can be used for defects of different sizes with the option of in situ distraction. No cases of implant failure, dislocation, or other implant-related complication have been observed. As a consequence of this prospective series, an additional implant size has been added, and the distraction device (spreading forceps) has been modified for more powerful spreading.
authors.affiliation: Unfallchirurgische Klinik, Medizinische Hoschschule Hannover, Carl-Neuberg-Str. 1, 30623 Hannover, Germany. lange.uta@mh-hannover.de
authors.forename: Uta
authors.initials: U
authors.lastname: Lange
authors.forename: Christian
authors.initials: C
authors.lastname: Knop
authors.forename: Leonard
authors.initials: L
authors.lastname: Bastian
authors.forename: Michael
authors.initials: M
authors.lastname: Blauth
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures; D011446:Prospective Studies; D019736:Prostheses and Implants; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000379:methods*; D013904:Thoracic Vertebrae / Q000601:surgery*; D014025:Titanium; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D014025:Titanium