Function of bone morphogenetic protein signaling during mouse development.
Bone morphogenetic proteins (BMPs) play pleiotropic roles during development and after birth in many different organisms. BMPs are members of TGF-beta superfamily. There are more than 20 members with three type II receptors and three type I receptors. Genetic approaches using the mouse as a model system revealed many of the functions of BMPs. Particularly, results obtained through loss-of-function analyses of BMP ligands and their receptors are reviewed in this article.
Mishina
Yuji
Y
Molecular Developmental Biology Section, Laboratory of Reproductive and Developmental Toxycology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA. mishina@niehs.nih.gov
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development* / Q000502:physiology*; D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000502:physiology*; D051379:Mice; D015398:Signal Transduction / Q000502:physiology*
D019485:Bone Morphogenetic Proteins