Should we be performing more combined hematopoietic stem cell plus solid organ transplants?
Both bone marrow and solid organ transplants (SOTs) can be life saving for a wide variety of diseases. We reviewed the literature and summarized the experiences of dual transplants. In total, 37 patients received a SOT for organ failure after a previous hematopoietic stem cell transplant. In all, 12 subjects received SOTs followed by a bone marrow transplant, while three patients received simultaneous SOTs and bone marrow transplants. Of these 52 patients, 37 were alive at the time of the original report at follow-up times ranging from 3 months to 8 years. A special registry for data collection may prove helpful for obtaining long-term follow-up data and providing outcome information that may improve future patient survival.
Chiang
K Y
KY
Division of Pediatric Hematology/Oncology, Children's Healthcare of Atlanta, GA 30322, USA.
Lazarus
H M
HM
D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003131:Combined Modality Therapy; D016027:Heart Transplantation; D006801:Humans; D016030:Kidney Transplantation; D016031:Liver Transplantation; D016040:Lung Transplantation; D009102:Multiple Organ Failure / Q000628:therapy; D009369:Neoplasms / Q000628:therapy; D016377:Organ Transplantation / Q000379:methods*; D033581:Stem Cell Transplantation / Q000379:methods*; D017211:Treatment Failure