The first example of enantioselective isocyanosilylation of meso epoxides with TMSCN catalyzed by novel chiral organogallium and indium complexes.
The desymmetrization ring opening of meso epoxides using trimethylsilyl cyanide catalyzed by organogallium and indium complexes with binaphthol monoether derivatives as chiral ligands gave beta-isocyanohydrins with moderate to excellent enantioselectivities of up to 95% ee.
Zhu
Chengjian
C
Department of Chemistry, Nanjing University, Nanjing 210093, China. cjzhu@netra.nju.edu.cn
Yuan
Fang
F
Gua
Weijin
W
Pan
Yi
Y