Effects of leg venous hemodynamics on cardiovascular responses to lower body negative pressure and aging.
In aged people, decreases in stroke volume and cardiac output during orthostatic challenge are less. It is suggested that the stiffness of blood vessels is greater in the elderly, blunting leg venous pooling and drop in central blood volume in an upright position. Leg venous hemodynamics plays an important role in human cardiovascular homeostasis against gravitational stress. This study aimed to clarify how aging influences the leg venous hemodynamics and its contribution to cardiovascular homeostasis during lower body negative pressure (LBNP) in humans.
Fu
Q
Q
Dept. of Autonomic Neuroscience, Research Institute of Environmental Medicine, Nagoya University, Japan.
Iwase
S
S
Niimi
Y
Y
Kamiya
A
A
Michikami
D
D
Mano
T
T
D000328:Adult; D000368:Aged; D000375:Aging; D001783:Blood Flow Velocity; D002320:Cardiovascular Physiological Phenomena; D006439:Hemodynamics / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008150:Lower Body Negative Pressure; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation; D012039:Regional Blood Flow; D013564:Sympathetic Nervous System; D014690:Venous Pressure / Q000502:physiology*