Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms.
Recent literature on polyketide biosynthesis suggests that polyketide synthases have much greater diversity in both mechanism and structure than the current type I, II and III paradigms. These examples serve as an inspiration for searching novel polyketide synthases to give new insights into polyketide biosynthesis and to provide new opportunities for combinatorial biosynthesis.
Shen
Ben
B
Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, WI 53705, USA. bshen@pharmacy.wisc.edu
D001685:Biological Factors / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques; D009097:Multienzyme Complexes / Q000378:metabolism*
D001685:Biological Factors; D009097:Multienzyme Complexes