Flutamide-induced hepatotoxicity with possible potentiation by simvastatin.
We report a 65 years old male who presented with jaundice in February 2000. He was operated for prostate carcinoma and started on flutamide in May 1999. He developed anorexia in mid January and frank jaundice by end February. LFT showed cholestatic picture. Liver biopsy showed cholestasis. Flutamide was stopped and patient made slow recovery. Possible additional hepatotoxicity of simvastatin is discussed.
Ashar
Unnati
U
Department of Medicine, PD Hinduja Hospital and Medical Research Centre, Veer Savarkar Road, Mahim, Mumbai 400 016.
Desai
D
D
Bhaduri
Anita
A
D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D004357:Drug Synergism; D005485:Flutamide / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D019821:Simvastatin / Q000009:adverse effects*
D005485:Flutamide; D019821:Simvastatin