Effect of human urotensin-II infusion on hemodynamics and cardiac function.
Recent studies have shown that the vasoactive peptide urotensin-II (U-II) exerts a wide range of action on the cardiovascular system of various species. In the present study, we determined the in vivo effects of U-II on basal hemodynamics and cardiac function in the anesthetized intact rat. Intravenous bolus injection of human U-II resulted in a dose-dependent decrease in mean arterial pressure and left ventricular systolic pressure. Cardiac contractility represented by +/-dP/dt was decreased after injection of U-II. However, there was no significant change in heart rate or diastolic pressure. The present study suggests that upregulation of myocardial U-II may contribute to impaired myocardial function in disease conditions such as congestive heart failure.
Hassan
Ghada S
GS
The Montreal General Hospital, McGill University, Montreal, QC H3G 1A4, Canada.
Chouiali
Fazila
F
Saito
Takayuki
T
Hu
Fu
F
Douglas
Stephen A
SA
Ao
Zhaohui
Z
Willette
Robert N
RN
Ohlstein
Eliot H
EH
Giaid
Adel
A
D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D007260:Infusion Pumps; D007275:Injections, Intravenous; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D014579:Urotensins / Q000008:administration & dosage* / Q000494:pharmacology*; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology*
D014579:Urotensins; C029677:urotensin II