title: [Induction of apoptosis by preoperative passive immunotherapy in resectable stomach carcinoma].
abstract: The antibody SC-1 is a human IGM molecule, which binds to a tumor specific receptor. This SC-1 receptor is detectable on biopsies, it is present in about 50% of gastric cancers. After binding of the antibody to the receptor the tumor cells go into apoptosis. 50 patients expressing the SC-1 receptor on their tumors have been treated with SC-1 prior to gastrectomy. In 80% of cases apoptosis induction could be demonstrated in the tumors. The only side effect of the SC-1 therapy was a reversible episode of fever during antibody infusion in 8% of our patients.
authors.affiliation: Chirurgische Universitätsklinik, Universität Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg.
authors.forename: W
authors.initials: W
authors.lastname: Timmermann
authors.forename: B
authors.initials: B
authors.lastname: Illert
authors.forename: H P
authors.initials: HP
authors.lastname: Vollmers
authors.forename: V
authors.initials: V
authors.lastname: Krenn
authors.forename: H
authors.initials: H
authors.lastname: Rückle-Lanz
authors.forename: M
authors.initials: M
authors.lastname: Wilhelm
authors.forename: A
authors.initials: A
authors.lastname: Thiede
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000009:adverse effects; D061067:Antibodies, Monoclonal, Humanized; D017209:Apoptosis / Q000187:drug effects*; D001706:Biopsy; D003131:Combined Modality Therapy; D005743:Gastrectomy; D006801:Humans; D007116:Immunization, Passive; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010865:Pilot Projects; D013270:Stomach / Q000276:immunology / Q000473:pathology; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology / Q000601:surgery*
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; C111124:SC-1 monoclonal antibody
vernacular_title: Apoptoseinduktion durch präoperative passive Immuntherapie beim resektablen Magenkarzinom.