Evidence suggesting that chlorophyllin (CHLN) may act as an inhibitor or a promoter of genetic damage induced by chromium(VI) oxide (CrO3) in somatic cells of Drosophila.
In Drosophila, 48h-old larvae were pretreated for 24h with chlorophyllin (CHLN) or sucrose and then treated with chromium(VI) oxide (CrO(3)) immediately following completion of the pretreatment period (0-day delay) or delayed 1, 2 or 3 days. The effects were scored in the wing spot test. After delays of 0 and 1 day, clear evidence of a protective effect of CHLN was found. Contrarily, after delays of 2 and 3 days, the results showed a reversal, i.e. CHLN-related events appeared more frequently than those in the sucrose control suggesting a promoting effect. It would appear prudent that CHLN be tested in a variety of situations in any given organism before decisions are reached regarding its inhibitor/promoter effects.
Cruces
M P
MP
Departamento de Genetica, Instituto Nacional de Investigaciones Nucleares (ININ), Edo. de Mexico, Mexico city, Mexico.
Pimentel
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E
Zimmering
S
S
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002735:Chlorophyllides / Q000494:pharmacology*; D017608:Chromium Compounds / Q000494:pharmacology*; D004249:DNA Damage / Q000235:genetics; D004330:Drosophila / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D004336:Drug Antagonism; D004357:Drug Synergism; D005260:Female; D007814:Larva; D008297:Male; D013395:Sucrose / Q000494:pharmacology; D014921:Wings, Animal / Q000166:cytology / Q000187:drug effects / Q000254:growth & development
D016587:Antimutagenic Agents; D002735:Chlorophyllides; D017608:Chromium Compounds; D013395:Sucrose; C007020:chlorophyllin; C023600:chromic oxide