Surgical pathology of granulomatous interstitial pneumonia.
Agranulomatous interstitial pneumonia is a form of diffuse lung disease in which granulomas are a component of the histologic findings. The differential diagnosis is quite broad, but most cases represent examples of either sarcoidosis, diffuse granulomatous infections, or hypersensitivity pneumonitis. "Hot tub lung" is a recently described form of granulomatous interstitial pneumonia that appears to have some features of diffuse infections and some features of hypersensitivity pneumonitis. The pathologist's approach to these conditions can be facilitated by giving careful attention to the anatomic distribution of the granulomas, the qualitative features of the granulomas, and the histologic changes in the lung tissue around and away from the granulomas. These features, along with the results of cultures and special stains for micro-organisms and clinical and radiologic correlation allow for a diagnosis in the vast majority of cases.
Cheung
Oi Yee
OY
Department of Pathology and Laboratory Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Muhm
J R
JR
Helmers
R A
RA
Aubry
Marie-Christine
MC
Tazelaar
Henry D
HD
Khoor
Andras
A
Leslie
Kevin O
KO
Colby
Thomas V
TV
D003937:Diagnosis, Differential; D006099:Granuloma / Q000473:pathology / Q000601:surgery; D006801:Humans; D008168:Lung / Q000473:pathology* / Q000601:surgery; D017563:Lung Diseases, Interstitial / Q000209:etiology* / Q000473:pathology* / Q000601:surgery