Intraoperative neck staging using sentinel node biopsy and imprint cytology in oral cancer.
BACKGROUND
Nodal status is an important prognostic factor in oral cancer. Sentinel node studies may enable accurate identification of high-risk nodes without a formal neck dissection. Imprint cytology is an emerging tool to assist in the rapid intraoperative detection of nodal metastases with encouraging results in other solid tumors. This study was planned to evaluate a novel method of intraoperative staging using sentinel node biopsy and intraoperative imprint cytology in oral cancer.


METHODS
Thirty-two cases of oral cancer underwent sentinel node mapping using 1% isosulfan blue during the study period. The sentinel node was sent for evaluation by imprint cytology. The average time taken for reporting was 15 minutes. The result was compared with the final histopathology, which was taken as the "gold standard".


RESULTS
Sentinel nodes (SLN) were identified in 30 cases (93.75% identification rate), with two false negatives. Intraoperative imprint cytology (IIC) could accurately predict the nodal status in 28 of the 30 patients. There was one false-positive result and one false-negative result. The overall sensitivity, specificity, and accuracy of IIC were 87.5%, 95.4%, and 93.3 %, respectively.


CONCLUSIONS
Sentinel node biopsy along with IIC provides a reliable, inexpensive, and accurate method of intraoperative identification of the nodal status in oral cancer.
Asthana
Sonal
S
Department of Surgical Oncology, D'II/35 Ansari Nagar, All India Institute of Medical Sciences, New Delhi, 110029 India.
Deo
S V Suryanarayana
SV
Shukla
Nootan K
NK
Jain
Paresh
P
Anand
Mona
M
Kumar
Rajive
R
D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D003581:Cytodiagnosis; D006801:Humans; D007432:Intraoperative Period; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery; D009333:Neck; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012394:Rosaniline Dyes; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy
D012394:Rosaniline Dyes; C025484:iso-sulfan blue