[Exploration of acute graft versus host disease and its risk factors after allo-hematopoietic stem cell transplantation].
OBJECTIVE
To explore the incidence, prognosis and risk factors of the acute graft versus host disease (aGVHD) after allo-hematopoietic stem cell transplantation (allo-HSCT).


METHODS
The clinical data of 118 cases undergone 120 times of allo-HSCT were analyzed.


RESULTS
aGVHD was observed in 63 cases (52.57%) including 17 severe cases (14.17%). The patients with aGVHD had a poor outcome, the 2-year overall survival rates were 61.40%, 64.08% and 17.65% for the non aGVHD, mild (degree I-II) and severe (degree III-IV) aGVHD groups respectively (P < 0.01). However, the relapse rates were 12.48%, 20.53% and 0% with no statistic significance. Unrelated transplantation and HLA-mismatch were the risk factors for aGVHD.


CONCLUSIONS
aGVHD is a common complication after allo-HSCT, the earlier it takes place, the poorer the prognosis.
Chen
Yu-hong
YH
Institute of Hematology and People's Hospital of Peking University, Beijing 100044, China.
Huang
Xiao-jun
XJ
Guo
Nai-lan
NL
Ren
Han-yun
HY
Zhang
Yao-chen
YC
Xu
Lan-ping
LP
Gao
Zhi-yong
ZY
Lu
Dao-pei
DP
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D016019:Survival Analysis; D013997:Time Factors; D014184:Transplantation, Homologous