[Evolution of hepatitis C virus (HCV) infection acquired at birth]
Objectives Our aim was to analyze the evolution of HCV infection in children infected at birth. Methods Between September 1994 and December 1998 we analyzed in a prospective study 8 children born of anti-HCV and HCV RNA positive women. Each baby was controlled at birth, every 3 months during the first year of life, and then every 6 months searching for anti-HCV antibodies (ELISA 3, RIBA 2-3), HCV RNA (RT PCR), ALT and viral genotype. Results Viral RNA was detectable in the first 3 months of life in all babies (100%) and remained positive during the follow-up. Viral genotypes were the same for mothers and their children. In 6 babies (75%) ALT remained pathologic during follow-up. Conclusions HCV infection in children usually has an asymptomatic outcome; the infection has chronic features in the majority of cases.
Minola
E.
E
U.O. di Malattie Infettive e "Gruppo di Studio: Trasmissione Verticale di HCV", A.O. Ospedali Riuniti, Bergamo, Italy.
Berera
F.
F
Fracassetti
O.
O
Quinzan
G.
G
Lorenzi
N.
N
Delvecchio
G.
G
Andamento dell'infezione da virus dell'epatite C (HCV) acquisita alla nascita.