Axons guided by insulin receptor in Drosophila visual system.
Insulin receptors are abundant in the central nervous system, but their roles remain elusive. Here we show that the insulin receptor functions in axon guidance. The Drosophila insulin receptor (DInR) is required for photoreceptor-cell (R-cell) axons to find their way from the retina to the brain during development of the visual system. DInR functions as a guidance receptor for the adapter protein Dock/Nck. This function is independent of Chico, the Drosophila insulin receptor substrate (IRS) homolog.
Song
Jianbo
J
Brookdale Department for Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA.
Wu
Lingling
L
Chen
Zun
Z
Kohanski
Ronald A
RA
Pick
Leslie
L
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001369:Axons / Q000502:physiology*; D001665:Binding Sites; D015153:Blotting, Western; D001921:Brain / Q000166:cytology / Q000254:growth & development; D002352:Carrier Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D002454:Cell Differentiation; D048429:Cell Size; D004330:Drosophila / Q000235:genetics / Q000254:growth & development* / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D005123:Eye / Q000166:cytology / Q000254:growth & development; D005260:Female; D020439:Growth Cones / Q000502:physiology; D055504:Insulin Receptor Substrate Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017956:Photoreceptor Cells, Invertebrate / Q000166:cytology / Q000502:physiology*; D011233:Precipitin Tests; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases; D011972:Receptor, Insulin / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D012160:Retina / Q000166:cytology / Q000254:growth & development; D015398:Signal Transduction; D020798:Two-Hybrid System Techniques; D014795:Visual Pathways; D018909:src Homology Domains
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D029721:Drosophila Proteins; D055504:Insulin Receptor Substrate Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; C120233:chico protein, Drosophila; C099753:dock protein, Drosophila; C094982:InR protein, Drosophila; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; D011972:Receptor, Insulin