title: Functional properties of spice extracts obtained via supercritical fluid extraction.
abstract: In the present study the antioxidant, anticancer, and antimycobacterial activities of extracts from ginger (Zingiber officinale Roscoe), rosemary (Rosmarinus officinalis L.), and turmeric (Curcuma longa L.) were evaluated. The extracts were obtained using supercritical CO(2) with and without ethanol and/or isopropyl alcohol as cosolvent. The extracts' antioxidant power was assessed using the reaction between beta-carotene and linolenic acid, the antimycobacterial activity against M. tuberculosis was measured by the MABA test, and their anticancer action was tested against nine human cancer ancestries: lung, breast, breast resistant, melanoma, colon, prostate, leukemia, and kidney. The rosemary extracts exhibited the strongest antioxidant and the lowest antimycobacterial activities. Turmeric extracts showed the greatest antimycobacterial activity. Ginger and turmeric extracts showed selective anticancer activities.
authors.affiliation: LASEFI-DEA/FEA-UNICAMP (State University of Campinas), Caixa Postal 6121, 13083-970 Campinas, São Paulo, Brazil.
authors.forename: Patrícia F
authors.initials: PF
authors.lastname: Leal
authors.forename: Mara E M
authors.initials: ME
authors.lastname: Braga
authors.forename: Daisy N
authors.initials: DN
authors.lastname: Sato
authors.forename: João E
authors.initials: JE
authors.lastname: Carvalho
authors.forename: Marcia O M
authors.initials: MO
authors.lastname: Marques
authors.forename: M Angela A
authors.initials: MA
authors.lastname: Meireles
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D016588:Anticarcinogenic Agents / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D002245:Carbon Dioxide; D030024:Curcuma / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D020939:Zingiber officinale / Q000737:chemistry*; D009161:Mycobacterium / Q000187:drug effects / Q000254:growth & development; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology*; D027542:Rosmarinus / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D010936:Plant Extracts; D002245:Carbon Dioxide; C012596:turmeric extract