title: Growth and bone mineral density in long-lasting idiopathic hypercalciuria.
abstract: Growth retardation and osteopenia have been reported in some children with idiopathic hypercalciuria (IHC), particularly in those with nephrocalcinosis. The duration of hypercalciuria might be a risk factor for osteopenia. A retrospective longitudinal analysis of statural growth and a cross-sectional evaluation of bone mineral density (BMD) was carried out in 26 IHC children followed for 4-13 years. None of the patients had nephrocalcinosis. Growth, including pubertal growth spurt, was normal in all subjects. BMD Z score less than -1 was recorded in 3 subjects with hyperuricosuria. BMD Z score averaged -0.68+/-0.99 in the 9 subjects with associated hyperuricosuria and 0.21+/-0.64 in the 17 with occasional or no hyperuricosuria ( P=0.018). Our analysis shows that children with long-lasting IHC without nephrocalcinosis have normal growth, but those with associated hyperuricosuria may be at risk for osteopenia.
authors.affiliation: Department of Pediatrics, Second University of Naples, Naples, Italy. rosario.ditoro@unina2.it
authors.forename: Cesare
authors.initials: C
authors.lastname: Polito
authors.forename: Giovanni
authors.initials: G
authors.lastname: Iolascon
authors.forename: Barbara
authors.initials: B
authors.lastname: Nappi
authors.forename: Saverio
authors.initials: S
authors.lastname: Andreoli
authors.forename: Angela
authors.initials: A
authors.lastname: La Manna
mesh_terms: D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000453:epidemiology / Q000209:etiology*; D002118:Calcium / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D008297:Male; D009397:Nephrocalcinosis / Q000150:complications* / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D002118:Calcium