title: Modification of polymer surfaces: optimization of approaches.
abstract: Modification of polymer surfaces to achieve a surface with enhanced compatibility is an important means of obtaining improved biomaterials. Techniques are available for altering the hydrophilicity or charge of a surface, attaching macromolecules or attempting to resemble cell membranes. Relevant to the clinical success of a modified surface is the modification procedure and a procedure based on incorporation as opposed to surface treatment has potential advantages. The modification of plasticized vinyl chloride (PVC) by the incorporation of cyclodextrins is described. In comparison to unmodified PVC controls, cyclodextrin incorporation reduced fibrinogen adsorption, with the extent of reduction dependent on the type and quantity of cyclodextrin incorporated.
authors.affiliation: Bioengineering Unit, University of Strathclyde, Glasgow, UK. j.courtney@strath.ac.uk
authors.forename: J M
authors.initials: JM
authors.lastname: Courtney
authors.forename: X B
authors.initials: XB
authors.lastname: Zhao
authors.forename: H
authors.initials: H
authors.lastname: Qian
authors.forename: A
authors.initials: A
authors.lastname: Sharma
mesh_terms: D000327:Adsorption; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000378:metabolism; D003505:Cyclodextrins / Q000737:chemistry / Q000378:metabolism; D005340:Fibrinogen / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008970:Molecular Weight; D011143:Polyvinyl Chloride / Q000737:chemistry* / Q000378:metabolism; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D003505:Cyclodextrins; D005340:Fibrinogen; D011143:Polyvinyl Chloride