title: Pharmacological and phytochemical evaluation of Adiantum ceneatum growing in Brazil.
abstract: This work describes the phytochemical analysis and analgesic activity of a non polar fraction obtained from Adiantum cuneatum grown in Brazil. The results showed that the hexane fraction as well as two pure compounds, identified as filicene (1) and filicenal (2), given intraperitoneally, exhibited potent analgesic activity when evaluated in two models of pain in mice, writhing test and formalin-induced pain. Compound 1 presented a calculated ID50 value of 19.5 micromol/kg body weight, when evaluated in writhing test, being about 7-fold more active than some reference drugs, like as acetyl salicylic acid and acetaminophen. It also inhibited both phases (neurogenic and inflammatory) of the formalin test at 10 mg/kg (24 micromol/kg). The chemical composition of the plant grown in Brazil is similar to that grown in other countries. The results confirm and justify the popular use of this plant for the treatment of dolorous processes.
authors.affiliation: Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis-SC, Brasil.
authors.forename: Louisiane F V
authors.initials: LF
authors.lastname: Bresciani
authors.forename: Jacks P
authors.initials: JP
authors.lastname: Priebe
authors.forename: Rosendo Augusto
authors.initials: RA
authors.lastname: Yunes
authors.forename: Jacir
authors.initials: J
authors.lastname: Dal Magro
authors.forename: Franco
authors.initials: F
authors.lastname: Delle Monache
authors.forename: Fátima
authors.initials: F
authors.lastname: de Campos
authors.forename: Marcia Maria
authors.initials: MM
authors.lastname: de Souza
authors.forename: Valdir
authors.initials: V
authors.lastname: Cechinel-Filho
mesh_terms: D035681:Adiantum / Q000737:chemistry* / Q000254:growth & development; D000700:Analgesics / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001938:Brazil; D005260:Female; D005557:Formaldehyde; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry* / Q000254:growth & development
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D005557:Formaldehyde