Poly(ethylene glycol)-grafted poly(3-hydroxyundecenoate) networks for enhanced blood compatibility.
Poly(ethylene glycol)-grafted poly(3-hydroxyundecenoate) (PEG-g-PHU) networks were prepared by irradiating homogeneous solutions of poly(3-hydroxyundecenoate) (PHU) and the monoacrylate of poly(ethylene glycol) (PEG) with UV light. The resulting polymer networks were characterized by measuring the water contact angle, water uptake, and mechanical properties and by performing attenuated total reflectance infrared spectroscopy and scanning electron microscopy. These measurements showed that the PEG chains were present in polymer networks. Adsorption of blood proteins and platelets on cross-linked PHU (CLPHU) and PEG-g-PHU were examined using poly(L-lactide) (PLLA) surfaces as control. Blood proteins and platelets had significantly lower tendency of adhesion to surfaces composed of CLPHU and PEG-g-PHU networks than to PLLA. Blood compatibility of polymer networks increased as the fraction of grafted PEG increased. The results of this study suggest that PEG-g-PHU networks might be useful for blood-compatible biomedical applications.
Chung
Chung Wook
CW
Department of Microbiology, Chungnam National University, Daejeon 305-764, South Korea.
Kim
Hyung Woo
HW
Kim
Young Baek
YB
Rhee
Young Ha
YH
D000327:Adsorption; D000418:Albumins / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D001704:Biopolymers / Q000737:chemistry; D001798:Blood Proteins / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000494:pharmacology; D005340:Fibrinogen / Q000737:chemistry; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D010973:Platelet Adhesiveness; D011091:Polyesters; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011549:Pseudomonas; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014466:Ultraviolet Rays; D014476:Undecylenic Acids / Q000737:chemistry*; D005719:gamma-Globulins / Q000737:chemistry
D000418:Albumins; D001672:Biocompatible Materials; D001704:Biopolymers; D001798:Blood Proteins; D020099:Coated Materials, Biocompatible; D003432:Cross-Linking Reagents; D011091:Polyesters; D011108:Polymers; D014476:Undecylenic Acids; D005719:gamma-Globulins; C481189:poly(3-hydroxyundecenoate); D011092:Polyethylene Glycols; D005340:Fibrinogen