title: Pain, mood and opioid medication use in sickle cell disease.
abstract: Patients with sickle cell disease show wide variations in their experience of pain, and in the impact of pain on everyday functioning. This study examined relations between pain, mood, physical activity, and medication use in a longitudinal naturalistic self-monitoring study of 21 adult sickle cell patients over 12 months. Results suggest that opioid medication use is related to the impact of pain on daily life. Patients who use opioids more frequently for sickle cell pain show more disruption of their lives, with reduced activity levels and more pessimistic mood.
authors.affiliation: Imperial College School of Medicine, Brent Sickle Cell and Thalassaemia Center, Central Middlesex Hospital, London, UK. kofi@sickle-psychology.com
authors.forename: Kofi A
authors.initials: KA
authors.lastname: Anie
authors.forename: Andrew
authors.initials: A
authors.lastname: Steptoe
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000339:Affect / Q000187:drug effects; D000349:Africa / Q000208:ethnology; D000701:Analgesics, Opioid / Q000494:pharmacology / Q000627:therapeutic use*; D000755:Anemia, Sickle Cell / Q000523:psychology*; D001290:Attitude; D017691:Caribbean Region / Q000208:ethnology; D015331:Cohort Studies; D005006:Ethnicity; D005260:Female; D005500:Follow-Up Studies; D006445:Hemoglobin C Disease / Q000150:complications / Q000523:psychology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007511:Ischemia / Q000209:etiology / Q000503:physiopathology; D008131:London / Q000453:epidemiology; D008297:Male; D008499:Medical Records; D010146:Pain / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D010147:Pain Measurement; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data; D011788:Quality of Life; D012805:Sickle Cell Trait / Q000150:complications / Q000523:psychology; D017086:beta-Thalassemia / Q000150:complications / Q000523:psychology
chemical_list: D000701:Analgesics, Opioid