Factors predicting the outcome of intracytoplasmic sperm injection for infertility.
BACKGROUND
Male factor abnormality is the cause of infertility in about 20%-40% of infertile couples. Assisted reproduction with intracytoplasmic sperm injection is the only treatment option for severe forms of andrological infertility.


METHODS
We retrospectively analysed patients who had had intracytoplasmic sperm injection for male factor infertility. The clinical and laboratory factors that influenced the pregnancy rate were also analysed.


RESULTS
One hundred and seventy-five cycles in 164 couples were analysed. The fertilization, cleavage and pregnancy rates were similar in the groups that had had intracytoplasmic sperm injection with epididymal, testicular or ejaculate sperm. Univariate analysis of the clinical variables showed progressive reduction in pregnancy rate with increase in the woman partner's age and body mass index, and presence of pelvic disease, but these were not statistically significant. The age of the woman was the most significant factor affecting the pregnancy rate after adjusting for body mass index and pelvic disease in the multivariate analysis (OR 0.26, 95% CI: 0.08-0.84, p=0.03). The oocyte number, embryo transfer number and transfer day had no significant influence on the outcome.


CONCLUSIONS
The woman partner's age influences the success of assisted reproduction with intracytoplasmic sperm injection in male factor infertility. Thus, the chances of success are better if the couple seeks treatment at an early age.
George
Susan Shanti
SS
Reproductive Medicine Unit, Christian Medical College and Hospital, Vellore 632004, Tamil Nadu, India. rmu@cmcvellore.ac.in
Fernandes
Herman A
HA
Irwin
Christina
C
Chandy
Achamma
A
George
Korula
K
D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D015992:Body Mass Index; D004624:Embryo Transfer / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007246:Infertility / Q000628:therapy*; D008297:Male; D000292:Pelvic Inflammatory Disease / Q000453:epidemiology; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000706:statistics & numerical data*; D016896:Treatment Outcome