title: [Virulence factors of Helicobacter pylori: what are they?].
abstract: The pathogenic properties of Helicobacter pylori are due to the ability of this bacterium to survive in the acidic gastric juice, to freely move and multiply within the mucus, to colonize the gastric mucosa and persist as an extracellular bacterium for decades despite the strong immune local and cellular responses they trigger. Every H. pylori isolate expresses properties that permit them colonization and persistence. In contrast, isolates may or not be expressing properties that potentially contribute to the genesis of tissue lesions due to the direct action of deleterious bacterial products or to the induction and/or modulation of the inflammatory response associated with the expression of specific antigens. Those are designated as pathogenic factors and might be useful to discriminate isolates.
authors.affiliation: Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 28, rue du Dr-Roux, 75724 Paris Cedex 15.
authors.forename: Monica
authors.initials: M
authors.lastname: Contreras
authors.forename: Agnès
authors.initials: A
authors.lastname: Labigne
mesh_terms: D000942:Antigens, Bacterial; D005744:Gastric Acid; D016481:Helicobacter Infections / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D007249:Inflammation; D011157:Population Dynamics; D013534:Survival; D014774:Virulence
chemical_list: D000942:Antigens, Bacterial
vernacular_title: Quels sont les facteurs de virulence de Helicobacter pylori?