[Genetic programs in development of three-dimensional organs].
Regenerative medicine has become popular especially after establishment of human embryonic stem cells in 1998. Somatic stem cells are also potential candidates for cell therapy. For long-term success, however, an appropriate balance should be needed between clinical application and basic developmental biology. Mimicking what is happening in embryonic development could lead to a breakthrough for generating functional organs in vitro. This review provides an overview on how three-dimensional organs are formed.
Nishinakamura
Ryuichi
R
Division of Stem Cell Regulation, Institute of Medical Science, University of Tokyo.
D000818:Animals; D019521:Body Patterning / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D004622:Embryo, Mammalian / Q000166:cytology; D006801:Humans; D038081:Organogenesis / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics; D013234:Stem Cells; D014157:Transcription Factors / Q000502:physiology; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D051153:Wnt Proteins; D029961:Zebrafish Proteins