title: [Outline of treatment--strategy of initial therapy].
abstract: Immune thrombocytopenic purpura(ITP) is an autoimmune disorder characterized by a low platelet count and mucocutaneous bleeding. ITP is classified as acute or chronic ITP. In acute ITP, more than 70 percent of affected patients resolves within six months, irrespective of whether they receive therapy. By contrast, in chronic ITP, they receive the initial therapy including corticosteroids, followed by splenectomy when corticosteroid therapy is proved to be ineffective. Long-term remission is observed in 5-30% patients with corticosteroid therapy. Splenectomy produces remissions in 50-70% of patients evaluated 6-12 months after operation. Chronic refractory ITP, they receive immunosuppresants or a number of different treatment regimens. No single treatment algorysm is suitable for all patients.
authors.affiliation: Department of Hematology, Kitasato University, School of Medicine.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohtake
authors.forename: Kouji
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Masaaki
authors.initials: M
authors.lastname: Higashihara
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000628:therapy*; D013156:Splenectomy
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents