title: Does priming implementation with low-dose albumin reduce postoperative bleeding following cardiopulmonary bypass?
abstract: This study aimed to assess whether low doses of albumin in the priming solution for cardiopulmonary bypass (CPB) reduce postoperative bleeding. Three-hundred and seventy-seven patients undergoing CPB were retrospectively assigned to group A (154 patients, CPB primed with 20 ml/kg Ringer Lactate solution + 0.75 mg/kg albumin 20%) and group B (223 patients with 20 ml/kg Ringer Lactate). A significant difference was found in terms of reoperations for bleeding (group A 0/154 versus group B 9/223; P=0.033). The mean number of blood derivatives transfused per patient was higher in group B than in group A (P<0.001). Platelet count after CPB was higher in group A than in group B (175 +/- 52x10(3)/microl versus 131 +/- 70x10(3)/microl; P=0.045). The amount of postoperative bleeding was 525 ml versus 680 ml at 24 hrs (P<0.001), 819 ml versus 1102 ml at 48 hrs, (P<0.001), 963 ml versus 1294 ml at 72 hrs, (P<0.045) (group A versus group B respectively). Crystalloid priming with low-dose albumin reduces postoperative bleeding.
authors.affiliation: Department of Cardio-thoracic and Respiratory Sciences, Second University of Naples, Monaldi Hospital, Naples, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Onorati
authors.forename: G
authors.initials: G
authors.lastname: Santarpino
authors.forename: A
authors.initials: A
authors.lastname: Renzulli
authors.forename: M
authors.initials: M
authors.lastname: De Feo
authors.forename: L S
authors.initials: LS
authors.lastname: De Santo
authors.forename: A
authors.initials: A
authors.lastname: Della Corte
authors.forename: N
authors.initials: N
authors.lastname: Galdieri
authors.forename: M
authors.initials: M
authors.lastname: Cotrufo
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins / Q000494:pharmacology*; D001769:Blood / Q000187:drug effects*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects* / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010107:Oxygenators, Membrane / Q000009:adverse effects*; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D012189:Retrospective Studies; D012996:Solutions
chemical_list: D000418:Albumins; D012996:Solutions