Population-based human papillomavirus prevalence in Lampang and Songkla, Thailand.
To investigate the prevalence and determinants of human papillomavirus (HPV) infection, the primary cause of cervical cancer, we studied 1741 women >/=15 years of age from Lampang and Songkla, Thailand. Exfoliated cervical cells were collected for Papanicolaou smear screening and DNA detection of 36 different HPV types. Serum immunoglobulin G antibodies against L1 virus-like particles (anti-VLPs) of HPV-16, -18, -31, -33, and -58 were evaluated using enzyme-linked immunosorbent assay. Overall, 110 women (6.3%) were HPV DNA positive; the most common types were HPV-16, -52, and -72. The age-standardized prevalence of HPV DNA was higher among the 1035 women from Lampang (9.1%; 95% confidence interval [CI], 7.1-11.1) than among the 706 women from Songkla (3.9%; 95% CI, 2.3%-5.6%). Anti-VLPs were found in 21.8% of all women and were more frequent among women from Lampang (29.2%) than among women from Songkla (10.9%). Major risk factors for cervical HPV DNA were age <35 years, HSV-2 seropositivity, and having a husband with extramarital sexual partners.
Sukvirach
Sukhon
S
Research Division, National Cancer Institute, Bangkok, Thailand.
Smith
Jennifer S
JS
Tunsakul
Sirirat
S
Muñoz
Nubia
N
Kesararat
Vitaya
V
Opasatian
Oranuj
O
Chichareon
Saibua
S
Kaenploy
Vichien
V
Ashley
Rhoda
R
Meijer
Chris J L M
CJ
Snijders
Peter J F
PJ
Coursaget
Pierre
P
Franceschi
Silvia
S
Herrero
Rolando
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D015995:Prevalence; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000276:immunology / Q000821:virology
D000914:Antibodies, Viral; D004279:DNA, Viral