Treatment of meningioma: an update.
Aggressive surgical resection continues to be the mainstay of current meningioma management, with advances in microsurgical techniques facilitating the safety and effectiveness of this approach. Complete surgical removal of meningiomas provides the optimal opportunity for long-term remission. Advances in skull base surgical approaches have greatly improved patient outcomes for tumors in precarious locations once thought to be inoperable. For tumors that recur or are unresectable, stereotactic radiosurgery and conformal fractionated radiation therapy can provide safe, palliative treatment with favorable long-term outcomes. Additionally, advances in the understanding of molecular biologic and biochemical mechanisms underlying meningioma growth offer unique opportunities for potential treatment adjuncts for atypical and malignant tumors. This review discusses current understanding of meningioma pathology and accepted meningioma treatment paradigms. The technologic advances and experimental strategies for the future treatment of complex intracranial meningiomas are also discussed.
D'Ambrosio
Anthony L
AL
Department of Neurological Surgery, Neurological Institute of New York, 710 West 168th Street, New York, NY 10032, USA.
Bruce
Jeffrey N
JN
D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D006801:Humans; D008279:Magnetic Resonance Imaging; D008579:Meningioma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D019635:Neurosurgical Procedures; D011877:Radionuclide Imaging; D012008:Recurrence
D000970:Antineoplastic Agents