Hemodynamic segmentation of MR brain perfusion images using independent component analysis, thresholding, and Bayesian estimation.
Dynamic-susceptibility-contrast MR perfusion imaging is a widely used imaging tool for in vivo study of cerebral blood perfusion. However, visualization of different hemodynamic compartments is less investigated. In this work, independent component analysis, thresholding, and Bayesian estimation were used to concurrently segment different tissues, i.e., artery, gray matter, white matter, vein and sinus, choroid plexus, and cerebral spinal fluid, with corresponding signal-time curves on perfusion images of five normal volunteers. Based on the spatiotemporal hemodynamics, sequential passages and microcirculation of contrast-agent particles in these tissues were decomposed and analyzed. Late and multiphasic perfusion, indicating the presence of contrast agents, was observed in the choroid plexus and the cerebral spinal fluid. An arterial input function was modeled using the concentration-time curve of the arterial area on the same slice, rather than remote slices, for the deconvolution calculation of relative cerebral blood flow.
Kao
Yi-Hsuan
YH
Institute of Radiological Science, National Yang-Ming University, Taipei, Taiwan, ROC.
Guo
Wan-Yuo
WY
Wu
Yu-Te
YT
Liu
Kuo-Ching
KC
Chai
Wen-Yen
WY
Lin
Chiao-Yuan
CY
Hwang
Yi-Shuan
YS
Jy-Kang Liou
Adrain
A
Wu
Hsiu-Mei
HM
Cheng
Hui-Cheng
HC
Yeh
Tzu-Chen
TC
Hsieh
Jen-Chuen
JC
Mu Huo Teng
Michael
M
D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011336:Probability