title: Ostruthin: an antimycobacterial coumarin from the roots of Peucedanum ostruthium.
abstract: Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei and M. smegmatis. Minimum inhibitory concentrations (MIC) ranged between 3.4 to 107.4 microM and were comparable to those of ethambutol and isoniazid. Imperatorin (8-isopent-2-enyloxy-6,7-furanocoumarin) showed no activity at concentrations up to 1.9 mM. Umbelliferone (7-hydroxycoumarin) was only weakly active (MIC = 0.79 mM).
authors.forename: Andreas
authors.initials: A
authors.lastname: Schinkovitz
authors.forename: Simon
authors.initials: S
authors.lastname: Gibbons
authors.forename: Michael
authors.initials: M
authors.lastname: Stavri
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Cocksedge
authors.forename: Franz
authors.initials: F
authors.lastname: Bucar
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D019661:Apiaceae; D003374:Coumarins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D014468:Umbelliferones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000995:Antitubercular Agents; D003374:Coumarins; D010936:Plant Extracts; D014468:Umbelliferones; C008719:ostruthin