title: Phenolic compounds from Nymphaea odorata.
abstract: Assay-guided fractionation of the ethanol extract of Nymphaea odorata resulted in the identification of two lignans, one new (1) and one known (2), together with six known flavonol glycosides (3-8). The structures of 1-8 were established by spectroscopic analysis as nymphaeoside A (1), icariside E(4) (2), kaempferol 3-O-alpha-l-rhamnopyranoside (afzelin, 3), quercetin 3-O-alpha-l-rhamnopyranoside (4), myricetin 3-O-alpha-l-rhamnopyranoside (myricitrin, 5), quercetin 3-O-(6' '-O-acetyl)-beta-d-galactopyranoside (6), myricetin 3-O-beta-d-galactopyranoside (7), and myricetin 3-O-(6' '-O-acetyl)-beta-d-galactopyranoside (8). Compounds 3, 4, and 7 showed marginal inhibitory effect against fatty acid synthase with IC(50) values of 45, 50, and 25 microg/mL, respectively.
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, and Department of Pharmacology, School of Pharmacy, University of Mississippi, University, Mississippi 38677, USA.
authors.forename: Zhizhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Hala N
authors.initials: HN
authors.lastname: ElSohly
authors.forename: Xing-Cong
authors.initials: XC
authors.lastname: Li
authors.forename: Shabana I
authors.initials: SI
authors.lastname: Khan
authors.forename: Sheldon E
authors.initials: SE
authors.lastname: Broedel
authors.forename: Robert E
authors.initials: RE
authors.lastname: Raulli
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Cihlar
authors.forename: Charles
authors.initials: C
authors.lastname: Burandt
authors.forename: Larry A
authors.initials: LA
authors.lastname: Walker
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005431:Florida; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006868:Hydrolysis; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D030721:Nymphaea / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D005419:Flavonoids; D006027:Glycosides; D017705:Lignans; D010636:Phenols; C477579:nymphaeoside A; D064429:Fatty Acid Synthases