title: [Pharmacokinetics of bromazepam in 57 patients with acute drug intoxication].
abstract: Pharmacokinetic parameters of bromazepam were analyzed by 57 cases. The patients were admitted 7.3 +/- 8.9 hours (mean +/- S.D.) after ingestion of 88 +/- 127 mg bromazepam. Most patients had taken several drugs other than bromazepam and the number was 5.5 +/- 2.6 drugs. The serum bromazepam levels were 1,871 +/- 2,428 ng/ml and the elimination half-lives were 29 +/- 4 hours. Increased serum bromazepam levels were followed by extended elimination half-lives. There was no bromazepam toxic sign under 2,300 ng/ml. One case was treated with direct hemoperfusion and the therapy was effective.
authors.affiliation: National Tokyo Medical Center, Institute for Clinical Research, Department of Pharmacy.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Koyama
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shimazu
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kikuno
authors.forename: Hirosi
authors.initials: H
authors.lastname: Kaziwara
authors.forename: Hisanori
authors.initials: H
authors.lastname: Sekiguti
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics* / Q000506:poisoning*; D001960:Bromazepam / Q000493:pharmacokinetics* / Q000506:poisoning*; D005260:Female; D006207:Half-Life; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D001960:Bromazepam