Central nervous system involvement in autoimmune polyglandular syndrome.
We present a 33 year-old man, admitted because of transient deterioration of visual acuity. Magnetic resonance imaging showed diffuse central nervous system (CNS) demyelination, which largely resolved spontaneously within 4 months. The patient fulfilled the diagnostic criteria of APS type III, having autoimmune thyroiditis and alopecia universalis. In this patient, autoimmune activation against CNS antigens is thought to be the cause of reversible CNS demyelination.
Boz
Cavit
C
Department of Neurology, Medical Faculty of Karadeniz Technical University, Trabzon 61080, Turkey. cavitb@yahoo.com
Velioglu
Sibel
S
Altunayoğlu
Vildan
V
Ozmenoglu
Mehmet
M
Erem
Changir
C
D000328:Adult; D000505:Alopecia; D020278:Demyelinating Autoimmune Diseases, CNS / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications* / Q000473:pathology*; D012075:Remission, Spontaneous; D013577:Syndrome; D013966:Thyroiditis / Q000150:complications* / Q000473:pathology*