title: The Nogo-66 receptor: focusing myelin inhibition of axon regeneration.
abstract: CNS myelin inhibits axonal outgrowth in vitro and is one of several obstacles to functional recovery following spinal cord injury. Central to our current understanding of myelin-mediated inhibition are the membrane protein Nogo and the Nogo-66 receptor (NgR). New findings implicate NgR as a point of convergence in signal transduction for several myelin-associated inhibitors. Additional studies have identified a potential coreceptor for NgR as p75(NTR), and a second-messenger pathway involving RhoA that inhibits neurite elongation. Although these findings expand our understanding of the molecular determinants of adult CNS axonal regrowth, the physiological roles of myelin-associated inhibitors in the intact adult CNS remain ill-defined.
authors.affiliation: Departments of Neurology and Neurobiology, Yale University School of Medicine, PO Box 208018, New Haven, CT 06520, USA. stephen.strittmatter@yale.edu
authors.forename: Aaron W
authors.initials: AW
authors.lastname: McGee
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Strittmatter
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism; D000818:Animals; D001369:Axons / Q000502:physiology*; D002478:Cells, Cultured; D058851:GPI-Linked Proteins; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D009185:Myelin Proteins / Q000145:classification / Q000378:metabolism / Q000502:physiology*; D009186:Myelin Sheath / Q000502:physiology*; D018992:Myelin-Associated Glycoprotein / Q000378:metabolism; D063308:Myelin-Oligodendrocyte Glycoprotein; D009416:Nerve Regeneration / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D009473:Neuronal Plasticity; D000070798:Nogo Proteins; D000070816:Nogo Receptor 1; D051381:Rats; D020800:Receptor, Nerve Growth Factor; D011956:Receptors, Cell Surface / Q000502:physiology*; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000209:Acute-Phase Proteins; D058851:GPI-Linked Proteins; C571326:MOG protein, human; C571327:Mog protein, mouse; C571328:Mog protein, rat; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D000070798:Nogo Proteins; D000070816:Nogo Receptor 1; C000603199:RTN4 protein, human; C486580:RTN4R protein, human; D020800:Receptor, Nerve Growth Factor; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor; C000603201:Rtn4 protein, mouse; C000603197:Rtn4 protein, rat; C419790:Rtn4r protein, mouse; C486581:Rtn4r protein, rat; C010781:acute-phase protein rho