[In vitro susceptibility of different erythromycin-resistant phenotypes of Streptococcus pyogenes to moxifloxacin and other fluoroquinolones]
The aim of the present study was to evaluate the in vitro activity of moxifloxacin (BAY 12-8039) compared with ciprofloxacin, ofloxacin and sparfloxacin against 156 Group A beta-haemolytic Streptococcus (GABHS) strains. Sixty strains were macrolide- lincosamide- and streptogramin B susceptible; 16 strains exhibited a constitutive resistance phenotype; 32 strains exhibited an inducible phenotype; and 48 strains were characterized by the M-type efflux-dependent phenotype. The MICs were determined by an agar dilution method according to NCCLS-approved guidelines. Moxifloxacin showed an enhanced activity compared with the other fluoroquinolones against all the different macrolide-resistant phenotypes.
Novielllo
S.
S
Clinica Malattie Infettive, Seconda Universita degli Studi di Napoli, Italia.
Ianniello
F.
F
Esposito
S.
S
Novelli
A.
A
Sensibilita in vitro di differenti fenotipi di Streptococcus pyogenes eritromicina-resistenti a moxifloxacina ed altri fluorochinoloni.