The generation of 5'-deoxyadenosyl radicals by adenosylmethionine-dependent radical enzymes.
Adenosylmethionine-dependent radical enzymes provide a novel mechanism for generating the highly oxidizing 5'-deoxyadenosyl radical in an anaerobic reducing environment. Recent studies suggest a unique covalent interaction between adenosylmethionine and a catalytic iron-sulfur cluster that may promote inner-sphere electron transfer to the sulfonium, resulting in the reductive cleavage of a C[bond]S and the generation of a 5'-deoxyadenosyl radical. The utilization of this radical as a catalytic and stoichiometric oxidant in many different enzyme reactions reflects the broad diversity of radical enzymes throughout biology.
Jarrett
Joseph T
JT
Department of Biochemistry and Biophysics, University of Pennsylvania, 905B Stellar-Chance Laboratory, 422 Curie Boulevard, Philadelphia, PA 19104-6059, USA. jjarrett@mail.med.upenn.edu
D003839:Deoxyadenosines / Q000737:chemistry*; D004798:Enzymes / Q000737:chemistry*; D005609:Free Radicals; D012436:S-Adenosylmethionine / Q000737:chemistry*
D003839:Deoxyadenosines; D004798:Enzymes; D005609:Free Radicals; C033714:5'-deoxyadenosine; D012436:S-Adenosylmethionine