title: Effects of two methods of reconstruction of digestive tract after total gastrectomy on gastrointestinal motility in rats.
abstract: OBJECTIVE
  To compare the effects of Roux-en-Y and jejunum interposition reconstruction procedures after total gastrectomy on intestinal motility.
  
  
  METHODS
  Fifty male Sprague-Dawley rats were randomly divided into 5 groups: the control group (C), the laparotomy group (L), the jejunal transection group (JT) where the jejunum was transected 10 cm distal from the Treitz ligament and anastomosed, the Roux-en-Y group (RY) and the jejunal interposition group (JI) after total gastrectomy. To evaluate intestinal transit, the animals were given 0.1 ml Evans Blue solution through an orogastric tube. The rats were executed by CO(2) inhalation 30 minutes later and the intestinal transmit was determined as the distance between the site of esophageojejunal anastomosis and the most distal site of small intestine colored with blue.
  
  
  RESULTS
  One month after operation, the body weight of rats among JI and RY were almost identical (274.6+/-9.5 vs 270.4+/-10.6, P>0.05), but were significantly lighter than those of JT and L group. Four months after the operation, the body weight in the JI group increased compared to the preoperative level (345.2+/-15.7 g vs 299.5+/-8.3 g, P<0.01). However, the body weight of RY group decreased compared to preoperative (255.1+/-11.3 g vs 295.0+/-12.0 g, P<0.01). The difference was more significant at six months postoperative. Small bowel transmit time in RY was slower than that in JI group and C group (P<0.01).
  
  
  CONCLUSIONS
  Changes of body weight and intestinal motility in JI group are less influenced than in RY group.
authors.affiliation: Department of General Surgery, ZhongShan Hospital, Fudan University, Shanghai 200032, China. xyqin@zshospital.net
authors.forename: Xin-Yu
authors.initials: XY
authors.lastname: Qin
authors.forename: Yong
authors.initials: Y
authors.lastname: Lei
authors.forename: Feng-Lin
authors.initials: FL
authors.lastname: Liu
mesh_terms: D000713:Anastomosis, Roux-en-Y / Q000379:methods; D000818:Animals; D001835:Body Weight; D013505:Digestive System Surgical Procedures / Q000379:methods*; D005743:Gastrectomy; D005769:Gastrointestinal Motility; D005772:Gastrointestinal Transit; D007583:Jejunum / Q000601:surgery*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley