Isoxazole-based derivatives from Baylis-Hillman chemistry: assessment of preliminary hypolipidemic activity.
The synthesis of isoxazole-based derivatives utilizing Baylis-Hillman chemistry and results of their preliminary bioevaluation as hypolipidemic agents in triton model are described.
Patra
A
A
Medicinal Chemistry Division, Central Drug Research Institute, PO Box, 173, Lucknow 226001, India.
Batra
S
S
Bhaduri
A P
AP
Khanna
A
A
Chander
R
R
Dikshit
M
M
D000080:Acetals / Q000737:chemistry; D000178:Acrylamides / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D000818:Animals; D020650:Combinatorial Chemistry Techniques; D029744:Commiphora; D004353:Drug Evaluation, Preclinical; D005343:Fibrinolytic Agents / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use; D053149:Plant Gums; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000080:Acetals; D000178:Acrylamides; D000577:Amides; D005343:Fibrinolytic Agents; D000960:Hypolipidemic Agents; D007555:Isoxazoles; D008055:Lipids; D010936:Plant Extracts; D053149:Plant Gums; C018562:guggulu extract