title: [The effect of microgravity and head down immobilization on hemopoiesis in primates].
abstract: Objects of the investigation were peripheral blood and bone marrow cytology in 6 primates during readaptation following the 2-wk. space flights (SF) aboard biosatellites BION-9, 10 and 11, and ground-based simulations of 17-d sitting in the chairs of the Bios-primat capsule (4 primates) and 4-wk. head-down immobilization (-5 degrees, 12 primates). On completion of each of the three experiments, the hemopoietic system was characterized by a distinct nonspecific stress-reaction, i.e. neutrophilous leukocytosis against reductions of the lymphocyte and eosinophil counts. After SF and HD immobilization, the blood profile carried signs of a specific reaction which consisted of a hemoconcentration (hematocrit and hemoglobin) reduction during early readaptation and recovery as a result of erythropoiesis activation due to, primarily, blood redistribution and a decreased weight-bearing load. The specific reactions to HD immobilization were less significant and did not reveal themselves at all in the chaired primates.
authors.forename: T E
authors.initials: TE
authors.lastname: Burkovskaia
authors.forename: V I
authors.initials: VI
authors.lastname: Korol'kov
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D004920:Erythropoiesis / Q000502:physiology*; D006257:Head / Q000502:physiology*; D018476:Hypokinesia / Q000209:etiology; D007103:Immobilization / Q000502:physiology*; D008253:Macaca mulatta; D008297:Male; D013026:Space Flight; D013997:Time Factors; D014893:Weightlessness / Q000009:adverse effects*
vernacular_title: Vozdeĭstvie nevesomosti i antiortostaticheskoĭ gipokinezii na krovetvorenie u obez'ian.