title: Metastatic ovarian tumors: a review of 64 cases.
abstract: OBJECTIVE
  The goal was to review cases of metastatic ovarian tumor with respect to their clinical features.
  
  
  METHODS
  Sixty-four patients with pathologically confirmed metastatic ovarian carcinoma, who were treated between 1978 and 2002 at Osaka Medical Center for Cancer and Cardiovascular Diseases (OMCC), were reviewed and the clinical features examined.
  
  
  RESULTS
  We found that metastatic tumors accounted for 21.1% (64/304) of malignant ovarian tumors. Of 64 metastatic ovarian tumors, 26 originated from gynecologic organs, and 38, from nongynecologic organs. Gynecologic primary sites were the uterine body (23%), uterine cervix (14%), and fallopian tube (3%). Eight of nine cervical cancers with ovarian metastases were adenocarcinomas. Adenocarcinoma of the uterine cervix metastasized to the ovaries more frequently than squamous cell carcinoma (5.6% vs 0.1%, respectively; P < 0.01). Among 38 cases of metastatic ovarian tumors from nongynecologic organs, Krukenberg tumors, pathologically characterized by the presence of typical signet-ring cells, were found in 11 patients (29%). Most (8/11) had originated in the stomach. Half (19/38) were preoperatively diagnosed as metastases. The 5-year survival rate after resection of metastatic ovarian tumors from gynecologic organs was significantly higher than the rate after resection of such tumors from nongynecologic organs (47% vs 19%, respectively; P = 0.026).
  
  
  CONCLUSIONS
  Metastatic ovarian tumors are likely to be relatively common in Japan because of the high incidence of gastric cancer. In cases of pelvic tumor, metastatic ovarian tumor should always be included in the differential diagnoses. As the 5-year survival after resection of metastatic ovarian tumor is 19%, even for tumors from nongynecologic organs, it seems worthwhile to consider tumorectomy as the second cytoreduction.
authors.affiliation: Department of Gynecology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 3-3 Nakamichi, 1-Chome, Higashinari-ku, Japan.
authors.forename: Namiko
authors.initials: N
authors.lastname: Yada-Hashimoto
authors.forename: Toshiya
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Shoji
authors.initials: S
authors.lastname: Kamiura
authors.forename: Hozumi
authors.initials: H
authors.lastname: Seino
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ohira
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sawai
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kimura
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Saji
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology; D005833:Genital Neoplasms, Female / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000556:secondary*