Didmolamide A and B, two new cyclic hexapeptides from the marine ascidian Didemnum molle.
Two novel cyclic hexapeptides, didmolamides A and B, were isolated from the compound ascidian Didemnum molle collected in Madagascar. The structure of the two peptides was elucidated by interpretation of MS, COSY, HMQC, and HMBC data. The absolute configuration of all amino acids was determined to be l using Marfey's method for HPLC.
Rudi
Amira
A
School of Chemistry, Tel-Aviv University, Ramat Aviv 69978, Israel.
Chill
Liat
L
Aknin
Maurice
M
Kashman
Yoel
Y
D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008270:Madagascar; D013058:Mass Spectrometry; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014561:Urochordata / Q000737:chemistry*
D000596:Amino Acids; D010456:Peptides, Cyclic; C477590:didmolamide A; C477591:didmolamide B