Patients with dystrophinopathy show evidence of increased oxidative stress.
Duchenne muscular dystrophy (DMD) is associated with an increase in oxidative stress. We measured 24 h 8-hydroxy-2'-deoxyguanosine (8-OHdG) excretion in 24 patients with MD (DMD + Becker's MD), 23 with myotonic dystrophy, and 34 healthy controls. The 8-OHdG/creatinine ratio was higher in patients with dystrophinopathy ( upward arrow 48%, p <.01) but not myotonic dystrophy, as compared to healthy controls. These results indicate that 8-OHdG excretion can be used as a marker of oxidative stress in clinical trials with dystrophinopathy.
Rodriguez
M Christine
MC
Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Tarnopolsky
Mark A
MA
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D015415:Biomarkers / Q000652:urine; D001835:Body Weight; D016022:Case-Control Studies; D002648:Child; D003401:Creatine / Q000652:urine; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000378:metabolism* / Q000652:urine; D009223:Myotonic Dystrophy / Q000378:metabolism* / Q000652:urine; D018384:Oxidative Stress
D015415:Biomarkers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D003401:Creatine