[Metachronous multiple primary tumors of the female genitals. Role of radiotherapy in secondary tumorigenesis].
According to the Center's register, primary multiple tumors were detected in 584 patients (5%) (metachronous--413 (70.7%); synchronous--138 (23.6%) in 1960-1998. In 4.8%, both types were hormonally-dependent; familial cancer was identified in 10.8%. Out of 298 patients treated with radiation, 41 (13.8%) developed tumors in the area of exposure. Excessive dosage due to taking repeat courses for relapse was received by 10 (24.4%). Thirty patients (10.1%) had malignancies outside the exposed area, in distant organs. Such factors as total over dosage due to repeat courses, extensive exposure of the bone marrow and idiosyncrasy to radiotherapy were mainly responsible for secondary tumorigenesis both in and outside zone of exposure.
Bekhtereva
S A
SA
Regional Oncological Center, Chelyabinsk.
Vazhenin
A V
AV
D005260:Female; D005833:Genital Neoplasms, Female / Q000532:radiotherapy*; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000532:radiotherapy*; D016609:Neoplasms, Second Primary / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects
Metakhronnye pervichno-mnozhestvennye opukholi zhenskikh polovykh organov. Rol' luchevoĭ terapii v razvitii vtoroĭ opukholi.