title: Population-based human papillomavirus prevalence in Lampang and Songkla, Thailand.
abstract: To investigate the prevalence and determinants of human papillomavirus (HPV) infection, the primary cause of cervical cancer, we studied 1741 women >/=15 years of age from Lampang and Songkla, Thailand. Exfoliated cervical cells were collected for Papanicolaou smear screening and DNA detection of 36 different HPV types. Serum immunoglobulin G antibodies against L1 virus-like particles (anti-VLPs) of HPV-16, -18, -31, -33, and -58 were evaluated using enzyme-linked immunosorbent assay. Overall, 110 women (6.3%) were HPV DNA positive; the most common types were HPV-16, -52, and -72. The age-standardized prevalence of HPV DNA was higher among the 1035 women from Lampang (9.1%; 95% confidence interval [CI], 7.1-11.1) than among the 706 women from Songkla (3.9%; 95% CI, 2.3%-5.6%). Anti-VLPs were found in 21.8% of all women and were more frequent among women from Lampang (29.2%) than among women from Songkla (10.9%). Major risk factors for cervical HPV DNA were age <35 years, HSV-2 seropositivity, and having a husband with extramarital sexual partners.
authors.affiliation: Research Division, National Cancer Institute, Bangkok, Thailand.
authors.forename: Sukhon
authors.initials: S
authors.lastname: Sukvirach
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Smith
authors.forename: Sirirat
authors.initials: S
authors.lastname: Tunsakul
authors.forename: Nubia
authors.initials: N
authors.lastname: Muñoz
authors.forename: Vitaya
authors.initials: V
authors.lastname: Kesararat
authors.forename: Oranuj
authors.initials: O
authors.lastname: Opasatian
authors.forename: Saibua
authors.initials: S
authors.lastname: Chichareon
authors.forename: Vichien
authors.initials: V
authors.lastname: Kaenploy
authors.forename: Rhoda
authors.initials: R
authors.lastname: Ashley
authors.forename: Chris J L M
authors.initials: CJ
authors.lastname: Meijer
authors.forename: Peter J F
authors.initials: PJ
authors.lastname: Snijders
authors.forename: Pierre
authors.initials: P
authors.lastname: Coursaget
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
authors.forename: Rolando
authors.initials: R
authors.lastname: Herrero
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D015995:Prevalence; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000276:immunology / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral