title: Solid-phase synthesis of naltrindole derivatives using Fischer indole synthesis based on one-pot release and cyclization methodology.
abstract: [reaction: see text] We describe a new approach for the solid-phase synthesis of indoles 1 that involves a one-pot release and cyclization reaction of a solid-supported hydrazone through a Wang-type linker. Using this solid-phase methodology, we accomplished the synthesis of 40 naltrindole derivatives.
authors.affiliation: Department of Applied Chemistry, Tokyo Institute of Technology, Meguro, Tokyo 152-8552, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohno
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Kawamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ohtake
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nagase
authors.forename: Takashi
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009271:Naltrexone; C055382:naltrindole