[Creation of a controlled model of respiratory mycoplasmosis].
To create the controlled model of respiratory mecoplasmosis, laboratory animals with induced immunodefeciency were infected with M. pneumoniae strain having different degrees of virulence. Immunodeficient state was induced in susceptible animals (hamsters) by the injection of cyclophosphamide. The infection of immunodeficient animals with a virulent strain induced the development of severe manifest pneumonia with 50% mortality rate. The infection of the animals with induced immunodeficiency with the avirulent strain attenuated in the process of 10-year subculturing in acellular media led to the development of moderate pneumonia characterized by the proliferation of the infective agent in pulmonary tissues and the presence of pathomorphological changes. The simultaneous infection of control hamsters with the same strain did not induce the development of infection. The infection of the experimental animals with the avirulent strain in the presence of induced immunodeficiency resulted in the partial restoration of the virulent properties of the strain, which was manifested by the activation of the capacity of the infective agent for colonization and proliferation in body tissues of the animals.
Zigangirova
N A
NA
Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
Khoĭkova
O Ch
OCh
Barkhatova
O I
OI
Bezuglova
T V
TV
Rakovskaia
I V
IV
Gintsburg
A L
AL
D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000276:immunology; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008168:Lung / Q000382:microbiology / Q000473:pathology; D009175:Mycoplasma Infections / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology / Q000401:mortality; D009177:Mycoplasma pneumoniae / Q000166:cytology / Q000276:immunology / Q000472:pathogenicity*; D012141:Respiratory Tract Infections / Q000382:microbiology*; D014774:Virulence
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide
Sozdanie upravliaemoĭ modeli respiratornogo mikoplazmoza.