Coordinated expression of tracheal antimicrobial peptide and inflammatory-response elements in the lungs of neonatal calves with acute bacterial pneumonia.
Lung tissue removed from neonatal calves with acute Mannheimia haemolytica pneumonia showed that rapid up-regulation of the basal mRNA expression of tracheal antimicrobial peptide (TAP), NF-kappa B, and intercellular adhesion molecule 1 occurred after infection; TAP and interleukin 8 expression were highly correlated. This work suggests that the coordinated expression of beta-defensin and inflammatory elements occurs during bacterial pneumonia.
Caverly
Jessica M
JM
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011-1250, USA.
Diamond
Gill
G
Gallup
Jack M
JM
Brogden
Kim A
KA
Dixon
Richard A
RA
Ackermann
Mark R
MR
D021581:Active Transport, Cell Nucleus; D000208:Acute Disease; D000818:Animals; D000831:Animals, Newborn; D023181:Antimicrobial Cationic Peptides / Q000235:genetics*; D002417:Cattle; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis; D016209:Interleukin-8 / Q000235:genetics; D008168:Lung / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism; D018410:Pneumonia, Bacterial / Q000276:immunology* / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis
D023181:Antimicrobial Cationic Peptides; D016209:Interleukin-8; D016328:NF-kappa B; D012333:RNA, Messenger; D018799:Intercellular Adhesion Molecule-1; C068629:tracheal antimicrobial peptide, bovine