Monitoring blood coagulation with magnetoelastic sensors.
The determination of blood coagulation time is an essential part of monitoring therapeutic anticoagulants. Standard methodologies for the measurement of blood clotting time require dedicated personnel and involve blood sampling procedures. A new method based on magnetoelastic sensors has been employed for the monitoring of blood coagulation. The ribbon-like magnetoelastic sensor oscillates at a fundamental frequency, which shifts linearly in response to applied mass loads or a fixed mass load of changing elasticity. The magnetoelastic sensors emit magnetic flux, which can be detected by a remotely located pick-up coil, so that no direct physical connections are required. During blood coagulation, the viscosity of blood changes due to the formation of a soft fibrin clot. In turn, this change in viscosity shifts the characteristic resonance frequency of the magnetoelastic sensor enabling real-time continuous monitoring of this biological event. By monitoring the signal output as a function of time, a distinct blood clotting profile can be seen. The relatively low cost of the magnetoelastic ribbons enables their use as disposable sensors. This, along with the reduced volume of blood required, make the magnetoelastic sensors well suited for at-home and point-of-care testing devices.
Puckett
Libby G
LG
Department of Chemistry, University of Kentucky, Lexington, KY 40506-0055, USA.
Barrett
Gary
G
Kouzoudis
Dimitris
D
Grimes
Craig
C
Bachas
Leonidas G
LG
D000818:Animals; D001809:Blood Viscosity / Q000502:physiology*; D004548:Elasticity; D004867:Equipment Design; D019544:Equipment Failure Analysis; D018056:Hemorheology / Q000295:instrumentation* / Q000379:methods*; D006736:Horses; D006801:Humans; D008280:Magnetics / Q000295:instrumentation*; D051381:Rats; D013045:Species Specificity; D014159:Transducers; D014914:Whole Blood Coagulation Time / Q000295:instrumentation* / Q000379:methods*