Operative parameters that predict the outcomes of hepatic transplantation.
BACKGROUND
A growing discrepancy between the number of patients awaiting liver transplantation and the number of organs available mandates the use of even marginal organ donors in whom there is major risk of suboptimal graft function. A comprehensive analysis of operative parameters on the outcomes of liver transplantation has not been reported.


METHODS
We analyzed the impact of 24 operative variables on the survival of 942 consecutive primary liver allografts performed at a single center from June 1992 through December 1997. Univariate and Cox proportional hazards analysis was used to identify those variables with independent prognostic significance in graft survival. Resource utilization for variables with multivariate significance was also analyzed.


RESULTS
Of 12 intraoperative variables found to have significance in univariate analysis, three were significant by Cox multivariate analysis: 1) lack of immediate bile production by the graft intraoperatively, 2) platelet transfusion > or = 20 U, and 3) recipient urine output < or =2.0 mL/kg/h intraoperatively. Each of the three variables was associated with marked increases in hospital and Intensive Care Unit length of stay and hospital charges accrued during the admission for transplantation.


CONCLUSIONS
We identified three operative parameters that predict a poor outcome after liver transplantation. The presence of these indicators suggests that early retransplantation should be considered. Early identification of grafts likely to have poor function might also provide an opportunity for therapeutic intervention to salvage graft function.
Markmann
James F
JF
Department of Surgery, School of Medicine, Hospital of the University of Pennsylvania, 4th Floor Silverstein, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Markmann
Joseph W
JW
Desai
Niraj M
NM
Baquerizo
Angeles
A
Singer
Jennifer
J
Yersiz
Hasan
H
Holt
Curtis
C
Ghobrial
Rafik M
RM
Farmer
Douglas G
DG
Busuttil
Ronald W
RW
D000328:Adult; D001646:Bile / Q000378:metabolism; D003404:Creatinine / Q000652:urine; D005260:Female; D006085:Graft Survival; D017721:Hospital Costs; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data*; D016031:Liver Transplantation / Q000191:economics; D008297:Male; D017063:Outcome Assessment, Health Care; D017713:Platelet Transfusion; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012086:Reoperation
D003404:Creatinine