[Prophylaxis and treatment of serotonin insufficiency in surgical patients].
The authors demonstrate that appearance in blood of chemical substances (ligands) capable to bind with serotonin receptors of smooth muscles (SM) leads to serotonin insufficiency. Intravenous injection of serotonin adipinat corrects serotonin insufficiency (biochemical stage) which leads to restoration of disordered function of SM (pharmacological stage). Normal function of SM eliminates functional intestinal obstruction (from the first hours after surgery), vascular insufficiency, tissues hypoxia (clinical stage) in surgical patients with different diseases. Serotonin adipinat was used in more than 900 surgical patients. It is concluded that this drug is a necessary component of prophylaxis and treatment of functional intestinal obstruction, vascular insufficiency, local and regional tissues hypoxia.
Simonenkov
A P
AP
Fedorov
V D
VD
D000272:Adipates / Q000627:therapeutic use*; D015687:Cell Hypoxia / Q000187:drug effects; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology / Q000517:prevention & control; D012039:Regional Blood Flow / Q000187:drug effects; D012701:Serotonin / Q000097:blood*; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D014666:Vasomotor System / Q000187:drug effects
D000272:Adipates; D017366:Serotonin Receptor Agonists; D012701:Serotonin
Profilaktika i lechenie serotoninovoĭ nedostatochnosti u khirurgicheskikh bol'nykh.