Electroporation therapy in head and neck cancer.
OBJECTIVE
To prove the efficacy of electroporation therapy (EPT) in T1 and T2 squamous cell cancers of the oral cavity and oropharynx.


METHODS
Twelve patients were treated with EPT within the framework of a European trial. Tumors were infiltrated with a bleomycin solution and subsequently treated with EPT. Four weeks after treatment the necrotic mass at the site of the former tumor was resected with save margins and accurately examined histologically.


RESULTS
Whereas 10 specimens were completely free of cancer cells, 2 cases showed viable tumor cells.


CONCLUSIONS
EPT has the potential to serve as an interesting alternative in the treatment of head and neck cancer.
Burian
Martin
M
Department of Otolaryngology, Head and Neck Surgery, General Hospital of Vienna, Vienna Medical School, Vienna, Austria. martin.burian@akh-wien.ac.at
Formanek
Michael
M
Regele
Heinz
H
D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D001761:Bleomycin / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D018274:Electroporation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D011446:Prospective Studies; D018570:Risk Assessment; D012494:Sampling Studies; D016896:Treatment Outcome
D001761:Bleomycin