title: Mycophenolate mofetil (CellCept) for psoriasis: a two-center, prospective, open-label clinical trial.
abstract: BACKGROUND
  Mycophenolate mofetil (MMF) is an immune suppressant that selectively inhibits activated lymphocytes. Its usefulness in treating psoriasis has not been systematically investigated.
  
  
  OBJECTIVE
  To evaluate efficacy and safety of MMF as a monotherapy for psoriasis.
  
  
  METHODS
  This is a two-center, prospective, open-label clinical trial.
  
  
  RESULTS
  Twenty-three patients with moderate to severe psoriasis [mean psoriasis area and severity index (PASI) of 21.7] were treated with MMF 2-3 g/day for 12 weeks. Eighteen patients completed the study. The PASI was reduced by 24% (p < 0.001) at 6 weeks, and by 47% (p < 0.001) at 12 weeks. At the end of the treatment phase, 77% of the patients had significant reduction of PASI while 22% did not respond. The treatment was well tolerated. Five patients experienced mild nausea. One patient each had periorbital edema and pruritus. One patient had transient leukopenia.
  
  
  CONCLUSIONS
  In this noncontrolled trial, the majority of patients with moderate to severe psoriasis responded to mycophenolate mofetil monotherapy with few adverse events. A randomized, controlled trial should be considered to confirm the usefulness of MMF as a monotherapy for psoriasis.
authors.affiliation: Division of Dermatology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada. ywzhou@interchange.ubc.ca
authors.forename: Youwen
authors.initials: Y
authors.lastname: Zhou
authors.forename: Don
authors.initials: D
authors.lastname: Rosenthal
authors.forename: Jan
authors.initials: J
authors.lastname: Dutz
authors.forename: Vincent
authors.initials: V
authors.lastname: Ho
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D011446:Prospective Studies; D011565:Psoriasis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid