Frequency analyses of CSF flow on cine MRI in normal pressure hydrocephalus.
Our objective was to clarify intracranial cerebrospinal fluid (CSF) flow dynamics in normal-pressure hydrocephalus (NPH). Frequency analyses of CSF flow measured with phase-contrast cine MRI were performed. The CSF flow spectra in the aqueduct were determined in patients ( n=51) with NPH, brain atrophy or asymptomatic ventricular dilation (VD), and in healthy volunteers (control group; n=25). The changes in CSF flow spectra were also analyzed after intravenous injection of acetazolamide. Moreover, a phase transfer function (PTF) calculated from the spectra of the driving vascular pulsation and CSF flow in the aqueduct were assessed. These values were compared with the pressure volume response (PVR). The amplitude in the NPH group was significantly larger than that in the VD or control group because of a decrease in compliance. The phase in the NPH group was significantly different from that in either the VD or the control group, but no difference was found between the VD and control groups. The amplitude increased in all groups after acetazolamide injection. The PTF in the NPH group was significantly larger than in the control group, and a positive correlation was noted between PTF and PVR. Frequency analyses of CSF flow measured by cine MRI make it possible to noninvasively obtain a more detailed picture of the pathophysiology of NPH.
Miyati
Tosiaki
T
Department of Radiological Technology, School of Health Sciences, Faculty of Medicine, Kanazawa University, 5-11-80, Kodatsuno, Kanazawa, Ishikawa 920-0942, Japan. ramiyati@mhs.mp.kanazawa-u.ac.jp
Mase
Mitsuhito
M
Banno
Tatsuo
T
Kasuga
Toshio
T
Yamada
Kazuo
K
Fujita
Hiroshi
H
Koshida
Kichiro
K
Sanada
Shigeru
S
Onoguchi
Masahisa
M
D000086:Acetazolamide / Q000008:administration & dosage; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage; D001284:Atrophy / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D002555:Cerebrospinal Fluid / Q000737:chemistry* / Q000187:drug effects / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D004108:Dilatation, Pathologic / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000503:physiopathology; D004548:Elasticity; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000503:physiopathology; D007275:Injections, Intravenous; D019028:Magnetic Resonance Imaging, Cine; D008875:Middle Aged; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D013223:Statistics as Topic; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000503:physiopathology; D014057:Tomography, X-Ray Computed
D000927:Anticonvulsants; D000086:Acetazolamide