title: Significance of the juxtaoral organ (of Chievitz).
abstract: BACKGROUND
  Most physicians are unaware of the juxtaoral organ (of Chievitz) and its clinical significance. The aim of this review is to draw attention to the clinical importance of this organ.
  
  
  METHODS
  Review and interpretation of the English and non-English literature pertaining to the juxtaoral organ.
  
  
  RESULTS
  The juxtaoral organ is a small structure located within the soft tissue overlying the angle of the mandible in the buccotemporal space. It is composed of an epithelial parenchyma embedded in a highly organized connective tissue stroma rich in nerves and sensory receptors innervated by the buccal nerve. This metabolically active structure presumably serves as a mechanosensor in the lateral wall of the oral cavity. Needless surgical removal of this juxtaoral structure is therefore best avoided. In children, the normal organ may be discovered as a small mass in the cheeks, which may lead to extensive and unnecessary investigations. Hyperplasia of the parenchyma may occur, but carcinoma originating from this organ has not been reported.
  
  
  CONCLUSIONS
  Awareness of this normal anatomic structure is important, because the finding of epithelial islands intimately admixed with nerves could be misinterpreted as perineural invasion by carcinoma.
authors.affiliation: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA. lpantanowitz@hotmail.com
authors.forename: Liron
authors.initials: L
authors.lastname: Pantanowitz
authors.forename: Karoly
authors.initials: K
authors.lastname: Balogh
mesh_terms: D000818:Animals; D002610:Cheek; D003238:Connective Tissue / Q000098:blood supply* / Q000294:innervation*; D003937:Diagnosis, Differential; D006801:Humans; D008465:Mechanoreceptors / Q000166:cytology / Q000502:physiology*; D009059:Mouth Diseases; D009061:Mouth Mucosa / Q000098:blood supply* / Q000294:innervation*