The effect of taurine on the salt-dependent blood pressure increase in the voltage-dependent calcium channel beta 3-subunit-deficient mouse.
To examine the anti-hypertensive effect of taurine, we studied the effects of taurine on the salt-dependent blood pressure elevation, the electrocardiogram, and plasma catecholamine levels in the voltage-dependent calcium channel beta3-subunit-deficient mouse. In the wild-type mice, chronic high-salt loading (8% NaCl in chow) did not increase the blood pressure, whereas there was a significant increase in the systolic blood pressure in the beta3-subunit-deficient mice given a high-salt diet. Oral supplementation of taurine (3% in drinking water) could attenuate the increase in the blood pressure elicited by the high-salt diet. Plasma catecholamine levels were significantly decreased by the high-salt diet, and supplementation of taurine prevented those decreases in beta3-subunit-deficient mice. It is suggested, therefore, that chronic supplementation of taurine has an anti-hypertensive action in salt-dependent blood pressure elevation.
Hagiwara
Kunie
K
Department of Molecular Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
Kuroki
Gorou
G
Yuan
Pei Xiang
PX
Suzuki
Takashi
T
Murakami
Manabu
M
Hano
Takuzou
T
Sasano
Hironobu
H
Yanagisawa
Teruyuki
T
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D015220:Calcium Channels / Q000172:deficiency* / Q000235:genetics; D004837:Epinephrine / Q000097:blood; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009638:Norepinephrine / Q000097:blood; D017673:Sodium Chloride, Dietary / Q000494:pharmacology*; D013654:Taurine / Q000494:pharmacology*
D015220:Calcium Channels; D017673:Sodium Chloride, Dietary; D013654:Taurine; D009638:Norepinephrine; D004837:Epinephrine