title: Multicentre evaluation of a new assay for determination of carbohydrate-deficient transferrin.
abstract: OBJECTIVE
  The analytical performance of the new Tina-quant % carbohydrate-deficient transferrin (%CDT) was assessed in a multicentre study on Roche/Hitachi analysers.
  
  
  METHODS
  Intra-assay/total precision studies revealed median coefficients of variation (CVs) of 4.7/7.4% within the sites. Precision between the sites was proven using a serum panel.
  
  
  RESULTS
  Inter-laboratory CVs from 6.3 to 10.7% were obtained. The results of the participating laboratories compared well with high-performance liquid chromatography-UV technique fulfilling the criteria of a reference method for %CDT determination (slope 1.03, intercept -0.09% CDT, correlation 0.984). Good agreement was also found with the Axis-Shield %CDT microtitre test.
  
  
  CONCLUSIONS
  Data from this study indicate that reliable, well standardized %CDT results are obtained using the new assay.
authors.affiliation: Psychiatrische Klinik der Ludwig-Maximilian-Universität, München, Germany.
authors.forename: Markus J
authors.initials: MJ
authors.lastname: Schwarz
authors.forename: Ingrid
authors.initials: I
authors.lastname: Domke
authors.forename: Anders
authors.initials: A
authors.lastname: Helander
authors.forename: Pim M W
authors.initials: PM
authors.lastname: Janssens
authors.forename: Johannes
authors.initials: J
authors.lastname: Van Pelt
authors.forename: Beate
authors.initials: B
authors.lastname: Springer
authors.forename: Manfred
authors.initials: M
authors.lastname: Ackenheil
authors.forename: Klaus
authors.initials: K
authors.lastname: Bernhardt
authors.forename: Gerhard
authors.initials: G
authors.lastname: Weigl
authors.forename: Michael
authors.initials: M
authors.lastname: Soyka
mesh_terms: D015415:Biomarkers / Q000032:analysis; D016000:Cluster Analysis; D005069:Evaluation Studies as Topic; D006801:Humans; D007118:Immunoassay / Q000379:methods* / Q000592:standards; D008297:Male; D011933:Reagent Kits, Diagnostic; D015203:Reproducibility of Results; D044967:Serum / Q000737:chemistry*; D014168:Transferrin / Q000031:analogs & derivatives* / Q000032:analysis*
chemical_list: D015415:Biomarkers; D011933:Reagent Kits, Diagnostic; D014168:Transferrin; C056759:carbohydrate-deficient transferrin