New process for the preparation of methyl carbonates.
The methyl carbonate of HOBt was developed for the conversion of alcohols to carbonates. This method is superior to the use of methyl chloroformate or methyl pyrocarbonate, especially with more hindered alcohols. The reagent is a stable solid that is easily prepared on a multigram scale. [reaction: see text]
Wuts
Peter G M
PG
Chemical Process Research and Development, 1500-91-201, Pharmacia, Kalamazoo, MI 49001, USA. peter.g.wuts@pharmacia.com
Ashford
Scott W
SW
Anderson
Andrew M
AM
Atkins
Joseph R
JR