title: Isolation of sesquiterpenoids from sponge Dysidea avara and chemical modification of avarol as potential antitumor agents.
abstract: The marine sponge Dysidea avara contained avarol (1) and avarone (2). Avarol on acylation yielded 2',5'-O-dibenzoylavarol (3); 2,5'-O-(4-chlorobenzoyl)avarol (4); 2,5'-O-dicinnamoylavarol (5); 2,5'-O-(4-bromobenzoyl)avarol(6); 2',5'-O-dioctanoylavarol (7); 2',5'-O-(4-fluorobenzoyl)avarol (8) and diacetylavarol (9). The structural elucidation of all the compounds 1-9 have been done by spectral analysis. The cytotoxicity of these compounds were also determined and evaluated. Compounds 6 and 9 showed selective cytotoxicity against Hepa (human hepatoma) and KB cell lines respectively.
authors.affiliation: Institute of Marine Resources, National Sun Yat-sen University, 70 Lien Hai Rd., Kaohsiung, Taiwan, Republic of China.
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
authors.forename: Ching-Hau
authors.initials: CH
authors.lastname: Lu
authors.forename: Rupak
authors.initials: R
authors.lastname: Chakraborty
authors.forename: Yau-Haur
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D000215:Acylation; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D053138:Cyclohexenes; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells / Q000187:drug effects; D008517:Phytotherapy; D011161:Porifera; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D053138:Cyclohexenes; D012717:Sesquiterpenes; C046374:avarone; C023663:avarol