Susceptibilities of simian immunodeficiency virus to protease inhibitors.
We used a focal infectivity assay with HeLa H1-JC.37 cells to directly compare susceptibilities of simian immunodeficiency virus (SIV) and human immunodeficiency virus type 1 (HIV-1) to protease inhibitors. SIVmac239 was inhibited by indinavir, saquinavir, and ritonavir, with 50% effective concentrations (means +/- standard deviations) of 39 +/- 8, 55 +/- 3, and 13 +/- 5 nM, respectively. The corresponding values for inhibition of HIV-1 were 66 +/- 4, 47 +/- 10, and 25 +/- 14 nM, respectively.
Giuffre
Angelica C
AC
Center for Comparative Medicine, Department of Veterinary Molecular Biosciences, University of California, Davis, Davis, California 95616, USA.
Higgins
Joanne
J
Buckheit
Robert W
RW
North
Thomas W
TW
D004305:Dose-Response Relationship, Drug; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D019469:Indinavir / Q000494:pharmacology; D019438:Ritonavir / Q000494:pharmacology; D019258:Saquinavir / Q000494:pharmacology; D015302:Simian Immunodeficiency Virus / Q000187:drug effects*
D017320:HIV Protease Inhibitors; D019469:Indinavir; D019258:Saquinavir; D019438:Ritonavir