Assembly of cell regulatory systems through protein interaction domains.
The sequencing of complete genomes provides a list that includes the proteins responsible for cellular regulation. However, this does not immediately reveal what these proteins do, nor how they are assembled into the molecular machines and functional networks that control cellular behavior. The regulation of many different cellular processes requires the use of protein interaction domains to direct the association of polypeptides with one another and with phospholipids, small molecules, or nucleic acids. The modular nature of these domains, and the flexibility of their binding properties, have likely facilitated the evolution of cellular pathways. Conversely, aberrant interactions can induce abnormal cellular behavior and disease. The fundamental properties of protein interaction domains are discussed in this review and in detailed reviews on individual domains at Science's STKE at http://www.sciencemag.org/cgi/content/full/300/5618/445/DC1.
Pawson
Tony
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Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada. pawson@mshri.on.ca
Nash
Piers
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D020816:Amino Acid Motifs; D000818:Animals; D001665:Binding Sites; D020134:Catalytic Domain; D002468:Cell Physiological Phenomena; D016764:Cell Polarity; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D019143:Evolution, Molecular; D007700:Kinetics; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D040901:Proteomics; D011956:Receptors, Cell Surface / Q000378:metabolism; D020449:Repetitive Sequences, Amino Acid; D015398:Signal Transduction
D004798:Enzymes; D011506:Proteins; D011956:Receptors, Cell Surface