Concordia discors: duality in the origin of the vertebrate tail.
The vertebrate tail is an extension of the main body axis caudal to the anus. The developmental origin of this structure has been a source of debate amongst embryologists for the past century. Some view tail development as a continuation of the morphogenetic processes that shape the head and trunk (i.e. gastrulation). The alternative view, secondary development, holds that the tail forms in a manner similar to limb development, i.e. by secondary induction. Previous developmental studies have provided support for both views. Here I revisit these studies, describing caudal morphogenesis in select vertebrates, the associated genes and developmental defects, and, as a relevant aside, consider the developmental and evolutionary relationships of primary and secondary neurulation. I conclude that caudal development enlists both gastrulation and secondary induction, and that the application of recent high-resolution cell labelling technology may clarify how these discordant programmes interact in building the vertebrate tail.
Handrigan
Gregory R
GR
Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada. ghandrig@dal.ca
D000818:Animals; D005075:Biological Evolution; D001717:Birds; D004627:Embryonic Induction / Q000502:physiology*; D005775:Gastrula / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D008322:Mammals; D009024:Morphogenesis / Q000502:physiology; D009420:Nervous System / Q000196:embryology; D010802:Phylogeny; D013623:Tail / Q000196:embryology*; D014714:Vertebrates / Q000196:embryology*; D014981:Xenopus; D015027:Zebrafish