title: [Gene diagnostics of acute persistent Leptospira infection].
abstract: The results of clinical trials carried out in different foci have demonstrated high diagnostic value of analysis made with the use of the polymerase chain reaction (PCR) at early stages of Leptospira infection caused by infective agents of the serogroups Grippotyphosa, Canicola and Icterohaemorrhagiae. The possibility of leptospiremia lasting considerably longer than heretofore believed to be possible, as well as the persistence of leptospires in the liquor of patients after the acute phase of the disease is over, i.e. during the early and late convalescence periods, has been shown. This is indicative of good prospects of using the PCR analysis not only for early rapid diagnostics of Leptospira infections, but also for controlling the course of the infection, for prognosticating early and late complications of the disease, as well the mechanisms of pathogenesis.
authors.affiliation: Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Anan'ina
authors.forename: A P
authors.initials: AP
authors.lastname: Samsonova
authors.forename: V V
authors.initials: VV
authors.lastname: Lebedev
authors.forename: E M
authors.initials: EM
authors.lastname: Petrov
authors.forename: E N
authors.initials: EN
authors.lastname: Esipov
mesh_terms: D000208:Acute Disease; D000907:Antibodies, Bacterial / Q000097:blood; D003289:Convalescence; D004269:DNA, Bacterial / Q000032:analysis / Q000097:blood; D006801:Humans; D007919:Leptospira / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D007921:Leptospira interrogans / Q000145:classification / Q000302:isolation & purification; D007922:Leptospirosis / Q000175:diagnosis* / Q000235:genetics / Q000382:microbiology; D016133:Polymerase Chain Reaction; D011379:Prognosis; D012680:Sensitivity and Specificity; D012703:Serotyping; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D004269:DNA, Bacterial
vernacular_title: Genodiagnostika ostroĭ i persistentnoĭ leptospiroznoĭ infektsii.