[The influence of select pathophysiologic factors of acute pancreatitis on erythrocytes' deformability examined in vitro].
Deformability of erythrocytes is essential factor in maintenance of blood flow in microcirculation. Deformability of erythrocytes during sepsis, including severe acute pancreatitis, decreases. The aim of the study was to examine in vitro influence of most common etiological factors and determinants of severity of acute pancreatitis on deformability of erythrocytes measured by means of laser diffractometry. We found that ethanol, bilirubin, sodium taurocholate have no effect on deformability of erythrocytes. Trypsin revealed positive effect on deformability of erythrocytes. Acetaldehyde and superoxide anion decrease deformability of erythrocytes in low shear stresses, whereas platelet activating factor and lipopolysaccharide are potent to decrease the deformability of erythrocytes mainly in high shear stresses.
Chmiel
Bogdan
B
Kliniki Chirurgii Ogólnej i Transplantacyjnej, Slaskiej Akademii Medycznej w Katowicach.
D000079:Acetaldehyde / Q000097:blood; D000208:Acute Disease; D000328:Adult; D001663:Bilirubin / Q000097:blood; D002756:Cholagogues and Choleretics / Q000097:blood; D004907:Erythrocyte Deformability / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000097:blood; D016877:Oxidants / Q000097:blood; D010195:Pancreatitis / Q000097:blood*; D010972:Platelet Activating Factor / Q000378:metabolism; D013481:Superoxides / Q000097:blood; D013656:Taurocholic Acid / Q000097:blood; D014357:Trypsin / Q000097:blood
D002756:Cholagogues and Choleretics; D008070:Lipopolysaccharides; D016877:Oxidants; D010972:Platelet Activating Factor; D013481:Superoxides; D013656:Taurocholic Acid; D014357:Trypsin; D000079:Acetaldehyde; D001663:Bilirubin
Wpływ wybranych czynników patofizjologicznych ostrego zapalenia trzustki na odkształcalność krwinek czerwonych in vitro.