Impact of carbohydrate and fat intake on weight-reducing efficacy of orlistat.
BACKGROUND
Orlistat treatment of obesity results in a poor long-term weight loss (< 5%) in about 30% of patients.


OBJECTIVE
Total energy and macronutrient intake were examined to assess the effect of a change in eating habits on weight loss.


METHODS
Sixty-two patients consumed a hypocaloric diet, together with orlistat (3 x 120 mg/day), for 72 weeks, with a maximal fat allowance of 30% of the energy intake. At regular intervals, food diaries were recorded.


RESULTS
Fifty-six patients completed the study and lost 8.5 +/- 0.88 kg (P < 0.001). Energy intake was approximately 1500 kcal/day during the entire study period. In three sub-groups established according to weight loss (1, < 5%; 2, > 5% and < 10%; 3, > 10%), fat intake was within the recommended range in all groups during the first 6 months, but thereafter only in group 3. All groups increased their carbohydrate consumption, with the greatest increase in group 1, which could account for the rapid regain of initially lost body weight in this group.


CONCLUSIONS
At the beginning of a weight management programme in conjunction with orlistat, a low fat intake is advised for an efficient reduction in body weight. Subsequently, in patients with poor long-term weight loss, dietary recommendations must also consider carbohydrate restriction to ensure an adequate hypocaloric diet.
Ullrich
A
A
Tiefenthal Hospital, Saarbrücken, Germany.
Erdmann
J
J
Margraf
J
J
Schusdziarra
V
V
D000293:Adolescent; D000328:Adult; D000368:Aged; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D015992:Body Mass Index; D018752:Diet, Fat-Restricted; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000494:pharmacology*; D002149:Energy Intake; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007783:Lactones / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy / Q000188:drug therapy*; D000077403:Orlistat; D015431:Weight Loss / Q000187:drug effects
D019440:Anti-Obesity Agents; D004040:Dietary Carbohydrates; D007783:Lactones; D000077403:Orlistat