Type and timing of protein feeding to optimize anabolism.
OBJECTIVE
The delivery rate of amino acids to an organism significantly affects protein anabolism. The rate can be controlled by the type and the timing of feeding. Our aim was to bring new insights to the way they may act.


RESULTS
During young and adult ages, when food supply is liberal, subjects can adapt to various modes of protein feeding. However, during food restriction, protein anabolism is favored when the delivery of amino acids is evenly distributed over the day, either with frequent meals, or through the use of slowly absorbed proteins like casein. In contrast, during aging, quickly absorbed protein sources become more efficient. During recovery after exercise, the timing of protein feeding after the end of exercise may or may not influence its anabolic effect, depending on the subject's age and the type of exercise.


CONCLUSIONS
The synchronization of variations in anabolic capability with amino acid supply partly explains the effects of the type and timing of protein feeding. This effect is modulated by the amount of amino acids required to increase whole-body proteins and by the signaling properties of some amino acids to stimulate protein synthesis. Indeed, the anabolic effect of amino acids is determined by their interaction with other anabolic factors (other nutrients or physiological factors, whose efficiency is mainly related to their effect on protein degradation). It is clear that benefits can be obtained from adapted protein feeding patterns.
Mosoni
Laurent
L
Protein Metabolism and Nutrition Unit, Inra, Theix, France. mosoni@clermont.inra.fr
Mirand
Philippe Patureau
PP
D000042:Absorption; D000375:Aging; D000596:Amino Acids / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism; D004032:Diet; D004044:Dietary Proteins / Q000008:administration & dosage*; D002149:Energy Intake; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D009124:Muscle Proteins / Q000096:biosynthesis; D014176:Protein Biosynthesis; D013997:Time Factors
D000596:Amino Acids; D004044:Dietary Proteins; D009124:Muscle Proteins