title: Some aspects on the anatomy and function of central cholecystokinin systems.
abstract: The distribution of some cholecystokinin (CCK) systems in the rat brain is reviewed focusing on mesencephalic dopamine neurones which coexpress CCK and, in particular, on cortico-striatal CCK neurones which probably have glutamate as their co-transmitter. Functional studies based on the effect of several CCK(B) antagonists on phencyclidine-induced motility suggest that CCK is involved in locomotor behaviour causing inhibition in phencyclidine-treated habituated rats. In contrast, in unhabituated rats CCK stimulates exploratory behaviour. These effects may be related to the cortico-striatal CCK/glutamatergic pathway. Moreover, these studies provide evidence for endogenous release of a neuropeptide with behavioural consequences.
authors.affiliation: Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Tomas.Hokfelt@neuro.ki.se
authors.forename: Tomas
authors.initials: T
authors.lastname: Hökfelt
authors.forename: David
authors.initials: D
authors.lastname: Blacker
authors.forename: Christian
authors.initials: C
authors.lastname: Broberger
authors.forename: Mario
authors.initials: M
authors.lastname: Herrera-Marschitz
authors.forename: Gretchen
authors.initials: G
authors.lastname: Snyder
authors.forename: Gilberto
authors.initials: G
authors.lastname: Fisone
authors.forename: Roser
authors.initials: R
authors.lastname: Cortés
authors.forename: Patrizia
authors.initials: P
authors.lastname: Morino
authors.forename: Zhi-Bing
authors.initials: ZB
authors.lastname: You
authors.forename: Sen Ove
authors.initials: SO
authors.lastname: Ogren
mesh_terms: D000818:Animals; D001345:Autoradiography; D001570:Benzodiazepinones / Q000494:pharmacology; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism*; D010671:Phenylurea Compounds / Q000494:pharmacology; D051381:Rats; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors
chemical_list: D001570:Benzodiazepinones; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; C090649:L 740093; D002766:Cholecystokinin