title: Biological factors and therapeutic modulation in radiotherapy of head and neck cancer.
abstract: The most recent clinical studies are increasingly concerned about the molecular factors in terms of prognosis, predictivity of response to treatments and development of novel, targeted therapeutic strategies. An integrated diagnostic and prognostic approach is envisaged where molecular biology with the study of biological markers "integrates" TNM to enhance the control of primary disease, resulting in a prolonged disease-free overall survival, earlier and effective control of locoregional progression and better quality of life (organ and function preservation). The prognostic or predictive role of the response to treatment for some markers (p53, EGFR, cyclin D1, telomerase activity) is defined in part in head and neck tumors. More statistically relevant data are necessary to establish which of these factors can permit a better selection of candidates for more aggressive or molecular targeted therapies or for a closer follow-up, thus contributing to the change of the natural history of these tumors.
authors.affiliation: Cattedra di Radioterapia, Istituto di Radiologia, Università Cattolica del S. Cuore, Policlinico A. Gemelli, Largo A. Gemelli 8, 00168 Roma, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Salvi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Almadori
authors.forename: Michela
authors.initials: M
authors.lastname: Quirino
authors.forename: Carmelo
authors.initials: C
authors.lastname: Pozzo
authors.forename: Luca
authors.initials: L
authors.lastname: Marmiroli
mesh_terms: D001685:Biological Factors; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans
chemical_list: D001685:Biological Factors