Elastin polymorphism haplotype and intracranial aneurysms are not associated in Central Europe.
OBJECTIVE
The occurrence of intracranial aneurysms and of aneurysmal subarachnoid hemorrhage are influenced by genetic factors. Recent genomic studies in Japan have defined 3 chromosomal loci and 1 haplotype of elastin polymorphisms as important risk factors, both for affected sib pairs and sporadic patients.


METHODS
We have genotyped 2 single nucleotide polymorphisms in the elastin gene and evaluated their allelic association with intracranial aneurysm in a Central European sample of 30 familial and 175 sporadic patients and 235 population controls.


RESULTS
We found no allelic association between this elastin polymorphism haplotype and intracranial aneurysm.


CONCLUSIONS
Our data probably reflect increased genetic heterogeneity of intracranial aneurysm in Europe compared with Japan.
Hofer
Anne
A
Department of Neurology, Johann Wolfgang Goethe-University Frankfurt am Main, Germany.
Hermans
Marcella
M
Kubassek
Nina
N
Sitzer
Matthias
M
Funke
Harald
H
Stögbauer
Florian
F
Ivaskevicius
Vytautas
V
Oldenburg
Johannes
J
Burtscher
Johannes
J
Knopp
Ulrich
U
Schoch
Beate
B
Wanke
Isabel
I
Hübner
Felix
F
Deinsberger
Wolfgang
W
Meyer
Bernhard
B
Boecher-Schwarz
Hans
H
Poewe
Werner
W
Raabe
Andreas
A
Steinmetz
Helmuth
H
Auburger
Georg
G
D000328:Adult; D017668:Age of Onset; D000483:Alleles; D017542:Aneurysm, Ruptured / Q000150:complications / Q000453:epidemiology*; D001317:Austria / Q000453:epidemiology; D002851:Chromatography, High Pressure Liquid; D004252:DNA Mutational Analysis; D004549:Elastin / Q000235:genetics*; D005260:Female; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D005858:Germany / Q000453:epidemiology; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D002532:Intracranial Aneurysm / Q000453:epidemiology / Q000235:genetics*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012422:Rupture, Spontaneous; D013345:Subarachnoid Hemorrhage / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*
D004549:Elastin