title: Prenatal sonographic chest and lung measurements for predicting severe pulmonary hypoplasia in left-sided congenital diaphragmatic hernia.
abstract: To assess the prenatal evaluation of lung hypoplasia in congenital diaphragmatic hernia (CDH), we attempted to measure the right lung area/thorax area ratio (rLT ratio) in normal fetuses and in seven cases of left-sided CDH. In addition, we analyzed early neonatal blood gas data, which were compared with the prenatal evaluation. The rLT ratio was significantly (p<0.05) higher in normal fetuses (0.27+/-0.02) than in CDH (0.14+/-0.18). The values of PaO(2), arterial-alveolar oxygen difference (A-aDO(2)) and oxygenation index (OI) showed no significant relationship with the rLT ratio in CDH at the early neonatal period. Three infants with CDH survived and showed significant higher values of rLT ratio compared with those in nonsurvived infants (p<0.05). All of the rLT ratios in nonsurvived infants were <0.11. PaO(2) at the early neonatal period was significantly (p<0.05) higher, and both A-aDO(2) and OI were significantly (p<0.05) lower in survived infants than in nonsurvived infants. These results indicated that prenatal evaluation of rLT ratio is useful to predict the severity of lung hypoplasia in infants with left-sided CDH, and blood gas analysis at early neonatal period is also useful to predict the neonatal outcome.
authors.affiliation: Perinatal Care Center, Yamaguchi University Hospital, Japan. miyabi@po.cc.yamaguchi-u-ac.jp
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nakata
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Sase
authors.forename: Kikue
authors.initials: K
authors.lastname: Anno
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sumie
authors.forename: Keiko
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kato
mesh_terms: D001784:Blood Gas Analysis; D005260:Female; D006548:Hernia, Diaphragmatic / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000000981:diagnostic imaging* / Q000473:pathology; D011247:Pregnancy; D015619:Respiratory System Abnormalities / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D013909:Thorax / Q000000981:diagnostic imaging*; D016216:Ultrasonography, Prenatal / Q000379:methods*