Increased frequency of HLA A2/DR4 and A2/DR8 haplotypes in young saskatchewan aboriginal people with diabetic end-stage renal disease.
OBJECTIVE
To determine the association of HLA with diabetic end-stage renal disease (DESRD) in Saskatchewan aboriginal people.


METHODS
This was a retrospective study of HLA profiles in four groups of Saskatchewan residents with ESRD diagnosed from 1980 to 1998: aboriginal people with and without DESRD, and non-aboriginal people with and without DESRD. The aboriginal DESRD group was also subdivided into those <or=50 and >50 years of age. Frequencies of individual and combinations of HLA antigens were compared between groups and subgroups.


RESULTS
HLA data were available for 634 subjects. Young aboriginal people with DESRD had a higher frequency of HLA-A2 than older AB DESRD subjects (69 vs. 36%; p = 0.03), and of HLA-DR4 and/or DR8 compared to older AB DESRD subjects (91 vs. 68%; p = 0.07) and AB non-DESRD subjects (91 vs. 67%; p = 0.03). Over 65% of young AB DESRD subjects had either an A2/DR4 or A2/DR8 haplotype (odds ratio 5.09 [confidence intervals 1.35, 20.15] versus older AB DESRD subjects; odds ratio 3.32 [confidence intervals 1.20, 9.3] versus AB non-DESRD subjects). Forty percent of young AB DESRD subjects were homozygous for at least one of A2, DR4 or DR8.


CONCLUSIONS
Our findings suggest that DESRD in young AB subjects with T2DM has a genetic basis related to HLA.
Dyck
Roland
R
Department of Medicine, University of Saskatchewan, Saskatoon, Canada. dyck@sask.usask.ca
Bohm
Clara
C
Klomp
Helena
H
D000328:Adult; D044467:American Indian or Alaska Native / Q000706:statistics & numerical data*; D016009:Chi-Square Distribution; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012525:Saskatchewan / Q000453:epidemiology
D006684:HLA-DR Antigens