Molecular patchwork: Chromosomal recombination between two Helicobacter pylori strains during natural colonization.
Genetic analysis of two Helicobacter pylori strains isolated from a single gastric biopsy showed evidence of extensive horizontal gene transfer. Several large recombinations were identified in the rdxA gene, which is involved in metronidazole resistance.
Smeets
Leonard C
LC
Department of Medical Microbiology and Infection Control, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. lc.smeets@vumc.nl
Arents
Nicolaas L A
NL
van Zwet
Anton A
AA
Vandenbroucke-Grauls
Christina M J E
CM
Verboom
Theo
T
Bitter
Wilbert
W
Kusters
Johannes G
JG
D000483:Alleles; D001483:Base Sequence; D002876:Chromosomes, Bacterial; D024881:Drug Resistance, Bacterial; D005753:Gastric Mucosa / Q000382:microbiology*; D016480:Helicobacter pylori / Q000187:drug effects / Q000235:genetics*; D008795:Metronidazole / Q000494:pharmacology; D008969:Molecular Sequence Data; D009601:Nitroreductases / Q000235:genetics; D011995:Recombination, Genetic
D008795:Metronidazole; C029492:aromatic NADH-dependent nitroreductase; D009601:Nitroreductases