Functions of a chitosan-orotic acid salt in the gastrointestinal tract.
A chitosan (CS)-orotic acid salt (CS-OT) was prepared, and the release of orotic acid (OT) from CS-OT as well as the adsorption of bile acids by CS-OT was investigated in vitro. The amount of OT released from CS-OT was about 2-2.7 micromol/mg CS-OT and this changed depending on the species of CS. CS-OT also adsorbed bile acids and the amount increased incrementally according to the number of amino group contained in CS. Furthermore, CS-OT was given to rats as feed in order to investigate the influence on serum cholesterol levels. A decrease in serum cholesterol levels was observed in the group, which was fed a diet containing CS-OT or CS for 1-2 weeks, but no differences in body weight changes were recognized. Therefore, CS-OT may be applied to treating hyperlipidemia.
Faculty of Pharmaceutical Science, Hokuriku University, Kanagawa-machi, Kanazawa, Japan. y-murata@hokuriku-u.ac.jp
Yoshifumi
Y
Murata
Naoko
N
Kojima
Susumu
S
Kawashima
D000277:Adjuvants, Pharmaceutic / Q000737:chemistry / Q000494:pharmacology*; D000284:Administration, Oral; D000327:Adsorption; D000818:Animals; D001647:Bile Acids and Salts / Q000737:chemistry; D001835:Body Weight / Q000187:drug effects; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D048271:Chitosan; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004338:Drug Combinations; D041981:Gastrointestinal Tract / Q000378:metabolism*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009963:Orotic Acid / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D000277:Adjuvants, Pharmaceutic; D001647:Bile Acids and Salts; D004338:Drug Combinations; D000960:Hypolipidemic Agents; D014280:Triglycerides; D002686:Chitin; D009963:Orotic Acid; D048271:Chitosan; D002784:Cholesterol