Normal bone accretion and effects of nutritional disorders in childhood.
Although osteoporosis is usually considered to be a health concern of the elderly, increased attention is being paid to children and adolescents who are at risk for developing this devastating disease. As osteoporosis is a preventable condition with no identified cure, focus has been placed on modifiable areas in a young person's life that may prevent the development of the disease. A child or adolescent's nutrition is an example of such an area. This review examines factors influencing normal bone development and emphasizes the importance of the adolescent years as a time for peak bone accretion. Current methods to evaluate skeletal status are examined, including the challenges that arise in interpreting bone densities in children who have growing bones. Children and adolescents who are at high risk for osteoporosis are discussed, with an emphasis on groups in whom poor nutrition likely mediates bone loss. Two models of malnutrition, anorexia nervosa and the female athlete triad, are discussed, with emphasis on the way in which each has deleterious effects on the adolescent skeleton. The promotion of skeletal health is ultimately the encouragement of good general health principles for all young people. Approaches for working with children and adolescents are reviewed, including literature supporting each strategy.
Gordon
Catherine M
CM
Department of Pediatrics, Harvard Medical School, and Divisions of Adolescent Medicine and Endocrinology, Children's Hospital, Boston, Massachusetts 02115, USA. Catherine.Gordon@tch.harvard.edu
D000293:Adolescent; D000856:Anorexia Nervosa / Q000150:complications; D015519:Bone Density; D001846:Bone Development / Q000502:physiology*; D002648:Child; D015362:Child Nutrition Disorders / Q000150:complications* / Q000209:etiology; D005260:Female; D006801:Humans; D010024:Osteoporosis / Q000209:etiology* / Q000517:prevention & control*; D012306:Risk; D013177:Sports