Assessment of egg nutrient compositional changes and residue in eggs, tissues, and excreta following oral administration of atorvastatin to laying hens.
Laying hens were fed a control diet alone or with 0.06 g of atorvastatin, a synthetic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, per 100 g of diet for 20 days. Compared to controls, egg yolks from treated hens contained greater amounts of amino acids and reduced levels of total fatty acids and cholesterol. In contrast, egg albumen amino acid contents were unaffected by dietary treatments. In a residue study, seven hens each received a single oral dose of approximately 20 microCi of [(14)C]atorvastatin. Approximately 71% of the radioactivity was recovered in the excreta and liver, whereas virtually no radioactivity was detected in kidney, heart, muscle, bile, plasma, or egg albumen at 15 days postdosing. Yolk radioactivity peaked at 4 days postdosing in six of the seven birds and was absent in eggs laid after day 10. Reminiscent of that of certain antibiotic drugs, the atorvastatin egg residue pattern appeared to coincide with the physiological pattern of daily yolk accretion within the ovary.
Elkin
Robert G
RG
Department of Animal Sciences, Purdue University, West Lafayette, Indiana 47907, USA. relkin@psu.edu
Furumoto
Emily J
EJ
Thomas
Charles R
CR
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics; D000069059:Atorvastatin; D002250:Carbon Radioisotopes; D002645:Chickens / Q000378:metabolism*; D002784:Cholesterol / Q000032:analysis; D004032:Diet; D004350:Drug Residues / Q000032:analysis; D004529:Egg White / Q000032:analysis; D004531:Eggs / Q000032:analysis*; D005227:Fatty Acids / Q000032:analysis; D005243:Feces / Q000737:chemistry*; D005260:Female; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics; D010047:Ovalbumin / Q000737:chemistry; D010058:Oviposition; D011758:Pyrroles / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics
D000596:Amino Acids; D000924:Anticholesteremic Agents; D002250:Carbon Radioisotopes; D005227:Fatty Acids; D006538:Heptanoic Acids; D011758:Pyrroles; D010047:Ovalbumin; D002784:Cholesterol; D000069059:Atorvastatin