Preventing ovarian hyperstimulation syndrome by inhibiting the effects of vascular endothelial growth factor.
OBJECTIVE
To evaluate whether inhibiting the effects of vascular endothelial growth factor can prevent the ovarian hyperstimulation syndrome.


METHODS
Rates were hyperstimulated with follicle-stimulating hormone injections. On the final day of stimulation, the rats were randomized to receive or not receive exogenous soluble fmslike tyrosine kinase (sFlt-1). Forty-eight hours later capillary permeability was determined by measuring the concentration of Evans blue dye (EB) in peritoneal irrigation fluid 3 minutes after an intravenous injection of EB.


RESULTS
The peritoneal EB level was statistically significantly lower in the hyperstimulated group, which received the sFlt-1, than in the stimulation-only group.


CONCLUSIONS
sFlt-1 may play a therapeutic role in management of the ovarian hyperstimulation syndrome by specifically inhibiting the effects of vascular endothelial growth factor.
Department of Obstetrics and Gynaecology, School of Medicine, Queen's University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, Northern Ireland, BT12 6BJ. b.mcelhinney@qub.ac.uk
Bernie
B
McElhinney
Joy
J
Ardill
Carolyn
C
Caldwell
Neil
N
McClure
D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D016228:Endothelial Growth Factors / Q000096:biosynthesis; D005070:Evans Blue; D005260:Female; D005640:Follicle Stimulating Hormone; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis; D008222:Lymphokines / Q000096:biosynthesis / Q000187:drug effects*; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D011336:Probability; D011505:Protein-Tyrosine Kinases / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D005070:Evans Blue; D005640:Follicle Stimulating Hormone; D011505:Protein-Tyrosine Kinases