Lymphocyte transformation test for medicinal herbs yields false-positive results for first-visit patients.
We performed lymphocyte transformation tests (LTTs) for toki (angelicae radix) and ogon (scutellariae radix) on first-visit patients who had never taken Kampo medicines. LTTs for both herbs were positive in 12 of 14 patients, suggesting that LTTs for these herbs are unreliable for the diagnosis of Kampo medicine-induced liver injury.
Department of Integrated Japanese Oriental Medicine, Gunma University School of Medicine, Maebashi, Japan. nmantani@showa.gunma-u.ac.jp
Naoki
N
Mantani
Toshiaki
T
Kogure
Jun'ichi
J
Tamura
Yutaka
Y
Shimada
Katsutoshi
K
Terasawa
D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D020835:Medicine, Kampo; D008875:Middle Aged; D008934:Mitogens; D010946:Plants, Medicinal / Q000009:adverse effects*; D012680:Sensitivity and Specificity
D004365:Drugs, Chinese Herbal; D008934:Mitogens