Some current ideas on the pathogenesis and the role of neuroprotection in glaucomatous optic neuropathy.
The primary features of glaucomatous optic neuropathy are characteristic changes in the optic nerve head, a decrease in number of surviving ganglion cells and a reduction in vision. It is now generally accepted that a number of factors, including elevated intraocular pressure, could lead to the changes seen in the optic nerve head and to obtain a pharmacological means to treat the causes will vary from patient to patient. In contrast, a cascade of events have been proposed to explain how the changes in the optic nerve head may lead to the slow and differential death of ganglion cells in the disease. It is also proposed that drugs (neuroprotectants) influencing this cascade of events can attenuate ganglion cell death and lead to the treatment of all glaucoma patients.
Nuffield Laboratory of Ophthalmology, Oxford University, Oxford, UK. Neville.Osborne@eye.ox.ac.uk
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D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D019610:Cytoprotection / Q000187:drug effects; D005901:Glaucoma / Q000150:complications* / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009898:Optic Disk / Q000187:drug effects / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control*; D012165:Retinal Ganglion Cells / Q000187:drug effects / Q000473:pathology*
D018696:Neuroprotective Agents