High recurrence rate after atypical resection for pancreatic metastases from renal cell carcinoma.
BACKGROUND
Pancreatic metastases from renal cell carcinoma are rare but highly resectable. The aim of this study was to review a series of patients with this condition.


METHODS
The study involved 22 consecutive patients with histologically proven pancreatic metastases from renal cell cancer.


RESULTS
Seventeen of the 22 patients had surgery. No patient died but eight of the 17 patients had a postoperative complication. Median follow-up was 33 (range 1-96) months. The 24- and 60-month survival probabilities were 0.84 and 0.53 respectively. Five patients who did not undergo surgery had 24- and 60-month survival probabilities of 0.53 and 0.26 respectively. The difference between the two groups was significant (P = 0.040).


CONCLUSIONS
Despite the slow development of these secondaries and their well encapsulated morphology, the high rate of recurrence after limited resection suggests that radical resection should be recommended.
Pancreatic Unit, Department of Surgical and Gastroenterological Sciences, Policlinico B. Roma, Verona University, Verona, Italy. Claudio.Bassi@univr.it
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Bassi
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Butturini
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Falconi
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Sargenti
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Mantovani
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Pederzoli
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000556:secondary* / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology; D009392:Nephrectomy / Q000379:methods; D010180:Pancreatectomy / Q000379:methods; D010190:Pancreatic Neoplasms / Q000556:secondary* / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000379:methods; D012333:RNA, Messenger / Q000032:analysis; D014057:Tomography, X-Ray Computed
D012333:RNA, Messenger