[The mechanism of protective effects of enalapril on experimental diabetic nephropathy of rats].
OBJECTIVE
To elucidate the mechanisms of renoprotective effects of ACEI on diabetic animals and patients.


METHODS
STZ-induced diabetic rats were treated with Enalapril and the levels of urine protein, TGF-beta and AGEs in renal tissue were measured and compared.


RESULTS
The results of TGF-beta quantitation and AGE fluorescence of Enalapril treatment group rats were the same as those of diabetic control rats.


CONCLUSIONS
Suppression of TGF-beta overexpression or AGEs accumulation was not implicated in the mechanisms of renoprotective effects of ACEI.
Department of Endocrinology, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
J
J
Fu
H
H
Tian
J
J
Liang
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000503:physiopathology; D004656:Enalapril / Q000627:therapeutic use*; D017127:Glycation End Products, Advanced / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016212:Transforming Growth Factor beta / Q000378:metabolism
D000806:Angiotensin-Converting Enzyme Inhibitors; D017127:Glycation End Products, Advanced; D016212:Transforming Growth Factor beta; D004656:Enalapril