Studies on modifying the tackiness and drug release of Kollicoat EMM 30 D coatings.
In the search for antitack additives for Kollicoat EMM 30 D (ethyl acrylate-methyl methacrylate 30% dispersion, Ph. Eur.) film coatings, various possibilities were investigated. The best results were obtained using a combination of simethicone and talc. This mixture was tested on propranolol, theophylline, and verapamil HCl blank pellets in a previously developed Kollicoat EMM 30 D basic formulation. Almost any desired drug release rate can be obtained with all three pellet formulations by varying the two pore formers hypromellose 3mPas and microcrystalline cellulose type 105. A thin application of colloidal silica onto the coated pellets additionally prevents them from sticking together during storage.
Fachhochschule Abt. Pharmatechnik, Sigmaringen, Germany.
H
H
Erdmann
S
S
Gebert
K
K
Kolter
G
G
Schepky
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004343:Drug Implants; D011109:Polymethacrylic Acids; D011433:Propranolol / Q000008:administration & dosage; D013806:Theophylline / Q000008:administration & dosage; D014700:Verapamil / Q000008:administration & dosage
D004343:Drug Implants; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid; D011433:Propranolol; D013806:Theophylline; D014700:Verapamil