Renal cell carcinoma in long-term survivors of advanced stage neuroblastoma in early childhood.
BACKGROUND
Renal cell carcinoma (RCC) is rare in children and comprises only 1-3% of all pediatric primary renal tumors. Recently, several case reports have described RCC developing in patients previously treated for advanced stage neuroblastoma (NB).


RESULTS
Our experience with four patients treated for advanced stage NB during early childhood who developed RCC later in life are added to 14 others in the literature.


CONCLUSIONS
These patients and our review of the literature suggest an association between RCC and NB that warrants further study.
Fleitz
Julie M
JM
The Children's Hospital, 1056 East 19th Avenue, Denver, CO 80218, USA. julie.fleitz@uchsc.edu
Wootton-Gorges
Sandra L
SL
Wyatt-Ashmead
Josephine
J
McGavran
Loris
L
Koyle
Martin
M
West
Daniel C
DC
Kurzrock
Eric A
EA
Martin
Kenneth W
KW
Odom
Lorrie F
LF
D000293:Adolescent; D000328:Adult; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D009447:Neuroblastoma / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed