Free radical-scavenging activity of Taiwanese native plants.
The 70% aqueous acetone extracts of ten Taiwanese native plants were evaluated by various antioxidant assays, including 1, 1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl (.OH) radicals, and reducing power assay. In the present study, extracts of Acer buerferianum var. formosanum, Cleyera japonica var. morii, Cyclobalanopsis stenophylla var. stenophylloides, and Machilus zuihoensis exhibited stronger activity against DPPH radicals, and their IC50 values ranged from 5.4 to 8.3 microg/ml. The ten selected extracts effectively inhibited the formation of .OH generated in the Fenton reaction system. Among the extracts whose reducing power activities were determined, A. buerferianum var. formosanum, C. japonica var. morii, C. stenophylla var. stenophylloides, Eriobotrya deflex, and M. zuihoensis showed high activity. The results indicate the 70% aqueous acetone extracts of A. buerferianum var. formosanum, C. japonica var. morii, C. stenophylla var. stenophylloides, and M. zuihoensis with great potency in these assay systems and may be candidates for the development of natural antioxidants.
Hou
W C
WC
Graduate Institute of Pharmacognosy Science, Taipei Medical University, Taipei, Taiwan.
Lin
R D
RD
Cheng
K T
KT
Hung
Y T
YT
Cho
C H
CH
Chen
C H
CH
Hwang
S Y
SY
Lee
M H
MH
D031002:Acer; D000975:Antioxidants / Q000494:pharmacology*; D001713:Biphenyl Compounds; D027424:Cinnamomum; D003855:Deoxyribose / Q000378:metabolism; D031983:Eriobotrya; D029962:Fagaceae; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000737:chemistry; D017665:Hydroxyl Radical / Q000378:metabolism; D020128:Inhibitory Concentration 50; D007501:Iron / Q000737:chemistry; D019770:Lauraceae; D027845:Malus; D010084:Oxidation-Reduction / Q000187:drug effects; D010851:Picrates / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D031991:Pyracantha; D031989:Pyrus; D032362:Styrax; D013624:Taiwan; D028242:Theaceae
D000975:Antioxidants; D001713:Biphenyl Compounds; C045076:Fenton's reagent; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; D017665:Hydroxyl Radical; D003855:Deoxyribose; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl; D007501:Iron