Successful triplet pregnancy and delivery after oocyte donation in an infertile female with chromosome mosaicism for monosomy X, partial trisomy X, and terminal Xp deletion.
OBJECTIVE
To present successful triplet pregnancy and delivery after oocyte donation and IVF in a female with chromosome mosaicism for monosomy X, partial trisomy X, and terminal Xp deletion.


METHODS
Descriptive case study.


METHODS
Large tertiary care hospital.


METHODS
A 23-year-old infertile woman with primary amenorrhea, short stature, and a mosaic karyotype of 45,X[10]/46,X,idic(X)(qter-->p22.3::p22.3-->qter)[40]. Fluorescence in situ hybridization investigation of the isodicentric X chromosome revealed terminal Xp deletion.


METHODS
Ultrasound and laparoscopic examinations revealed streak ovaries and a hypoplastic uterus. Oocyte donation and IVF resulted in a triplet pregnancy without major maternal complications.


METHODS
Ultrasound and laparoscopy.


RESULTS
A cesarean section was performed at 32 weeks gestation because of preterm labor and malpresentation. Three babies were delivered with birth weights of 1,514 g, 1,686 g, and 1,968 g. All infants survived and were healthy at 3 years of age.


CONCLUSIONS
With careful evaluation and counseling, assisted reproductive technology can be safely used in females with mosaic X chromosome abnormalities and gonadal dysgenesis.
Chen
Chih-Ping
CP
Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Republic of China, Taipei, Taiwan. cpc_mmh@yahoo.com
Hwu
Yuh-Ming
YM
Yeh
Li-Fan
LF
Chern
Schu-Rern
SR
Lee
Chen-Chi
CC
Wang
Wayseen
W
D000328:Adult; D002872:Chromosome Deletion; D041321:Chromosomes, Human, X; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009006:Monosomy; D009030:Mosaicism; D018587:Oocyte Donation; D011247:Pregnancy; D011272:Pregnancy, Multiple; D014314:Trisomy