Autoimmune hepatitis associated with Graves' disease.
A 31-year-old woman with Graves' disease with a 12-month-history of propylthiouracil intake and autoantibodies in the sera was admitted to our hospital. The differential diagnosis between autoimmune hepatitis and propylthiouracil-induced hepatitis was intractable. Steroid therapy was started and she showed a complete response to the treatment. Liver biopsy demonstrated acute hepatitis and plasma cell infiltration. A second liver biopsy, which was performed 10 months after starting steroid therapy, showed some inflammatory cells in the portal tracts. These findings suggest that she had been suffering from autoimmune hepatitis.
Third Department of Internal Medicine, Ehime University School of Medicine, Ehime.
Binglin
B
Cui
Masanori
M
Abe
Satoshi
S
Hidata
Seiji
S
Nakanishi
Bunzo
B
Matsuura
Kojiro
K
Michitaka
Kazuhisa
K
Yamamoto
Norio
N
Horiike
Morikazu
M
Onji
D000328:Adult; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000188:drug therapy; D019693:Hepatitis, Autoimmune / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D011441:Propylthiouracil / Q000009:adverse effects
D011441:Propylthiouracil