Co-proxamol and suicide: a study of national mortality statistics and local non-fatal self poisonings.
OBJECTIVE
To examine the incidence of suicides due to co-proxamol compared with tricyclic antidepressants and paracetamol, and to compare fatality rates for self poisonings with these drugs.


METHODS
Analysis of routinely collected national and local data on suicides and self poisonings.


METHODS
Records of suicides in England and Wales 1997-9; non-fatal self poisonings in Oxford District 1997-9.


METHODS
Office for National Statistics and Oxford monitoring system for attempted suicide.


METHODS
Incidence of suicides with co-proxamol or tricyclic antidepressants or paracetamol. Ratios of fatal to non-fatal self poisonings.


RESULTS
Co-proxamol alone accounted for 5% of all suicides. Of 4162 drug related suicides, 18% (766) involved co-proxamol alone, 22% (927) tricyclic antidepressants alone, and 9% (368) paracetamol alone. A higher proportion of suicides in the 10-24 year age group were due to co-proxamol than in the other age groups. The odds of dying after overdose with co-proxamol was 2.3 times (95% confidence interval 2.1 to 2.5) that for tricyclic antidepressants and 28.1 times (24.9 to 32.9) that for paracetamol.


CONCLUSIONS
Self poisoning with co-proxamol is particularly dangerous and contributes substantially to drug related suicides. Restricting availability of co-proxamol could have an important role in suicide prevention.
Hawton
Keith
K
Centre for Suicide Research, University of Oxford Department of Psychiatry, Warneford Hospital, Headington, Oxford OX3 7JX. keith.hawton@psych.ox.ac.uk
Simkin
Sue
S
Deeks
Jonathan
J
D000082:Acetaminophen / Q000506:poisoning*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000506:poisoning*; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning; D002648:Child; D011431:Dextropropoxyphene / Q000506:poisoning*; D004338:Drug Combinations; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011041:Poisoning / Q000401:mortality; D016012:Poisson Distribution; D012044:Regression Analysis; D013405:Suicide / Q000706:statistics & numerical data*; D015996:Survival Rate; D014852:Wales / Q000453:epidemiology
D000700:Analgesics; D000929:Antidepressive Agents, Tricyclic; D004338:Drug Combinations; D000082:Acetaminophen; C011800:acetaminophen, dextropropoxyphene, drug combination; D011431:Dextropropoxyphene