Cancer revoked: oncogenes as therapeutic targets.
Recent findings show that even the brief inactivation of a single oncogene might be sufficient to result in the sustained loss of a neoplastic phenotype. It is therefore possible that the targeted inactivation of oncogenes could be a specific and effective treatment for cancer. So why does oncogene inactivation cause tumour regression and will this be a generally successful approach for the treatment of human neoplasia?
Felsher
Dean W
DW
Division of Oncology, Department of Medicine, Stanford University, 269 Campus Drive, CCSR 1105, Stanford, California 94305-5151, USA. dfelsher@stanford.edu
D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy*; D009857:Oncogenes