Influence of angiotensin converting enzyme inhibitors on stable myocardial ischemia in menopausal cardiac patients.
OBJECTIVE



OBJECTIVE
The aim of the study was to investigate the influence of angiotensin converting enzyme inhibitor (Captopril) on stable demand ischemia in menopausal cardiac female patients.


METHODS
In a prospective non-randomized evaluation of the effect of angiotensin converting enzymes inhibitors (ACE-I) (Captopril) on demand myocardial ischemia, 16 normotensive menopause female patients, mean age of 52 years with stable angina and known coronary artery disease (CAD) but normal left ventricular function, underwent a treadmill exercise test (Bruce Protocol), at baseline (T1) and one week following (50-75 mg) a daily dose of Captopril (CAPT2). Onset of symptoms, duration of exercise, magnitude of peak ST depression and homodynamic parameters were monitored.


RESULTS
Captopril significantly increased the duration of exercise from (467 +/- 169 to 536 +/- 145 seconds, (p value < 0.02), but with increased peak of ST segment depression (from -1.4 +/- 0.6 mm to -1.93 +/- 1.2 mm, p value < 0.15). The double product remained unchanged (251 x 103 +/- 55 in T1 and 248 x 103 +/- 55 in CAPT2; the p value was < 0.8. All adverse effects on the treadmill were noted.


CONCLUSIONS
Although captopril tends to significantly effect prolongation of exercise time, there is no amelioration of the markers of ischemia.
Department of Internal Medicine (Cardiology Division), American University of Beirut-Medical Center, Beirut, Lebanon.
M S
MS
Arnaout
A
A
Khalil
S E
SE
Alam
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000517:prevention & control; D017698:Postmenopause; D011446:Prospective Studies
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril