Association of HLA-B12 with multiple sclerosis in India.
In Indian patients with Multiple Sclerosis it was observed, upon testing for serum determinable histocompatibility antigens, that HLA-B12 antigen was present in excess (77.7%), in comparison with normal controls (13.8%). In fact, in the sub-group of 'clinically definite' patients, the B12 antigen excess was remarkable (84%). These preliminary findings seem to point to a different immunogenetic profile of Indian MS patients in comparison with Western and Japanese series. Relevant published information relating to the HLA-B12 alleles in disease processes is discussed in order to provide a basis for further work.
Laboratory of Immunology in the Dept. of Pathology, Jaslok Hospital and Research Centre, Bombay, India.
N H
NH
Wadia
V S
VS
Trikannad
P R
PR
Krishnaswamy
D044466:Asian People; D020022:Genetic Predisposition to Disease; D015235:HLA-B Antigens / Q000235:genetics / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007194:India; D009103:Multiple Sclerosis / Q000208:ethnology / Q000235:genetics / Q000276:immunology*; D044465:White People
D015235:HLA-B Antigens; C035015:HLA-B12 antigen