Comparative analysis of azithromycin and ciprofloxacin in the treatment of chronic prostatitis caused by Chlamydia trachomatis.
A total of 89 patients, (>18 years), with symptoms of chronic prostatitis and inflammatory findings as well as the presence of Chlamydia trachomatis confirmed by DNA/RNA DIGENE hybridization method and/or by isolation, McCoy culture and Lugol stain in expressed prostatic secretion or in voided bladder urine collected immediately after prostatic massage, were examined. The patients were randomized to receive a total of 4.5 g of azithromycin for 3 weeks, given as a 3-day therapy of 1 x 500 mg weekly or ciprofloxacin 500 mg b.i.d. for 20 days. Patients' sexual partners were treated at the same time. Clinical and bacteriological efficacy were evaluated 4-6 weeks after the end of therapy. Significantly higher eradication (36/45: 17/44; P=0.0002) and a significantly higher clinical cure (31/45: 15/44; P=0.0021) were achieved in the group of patients treated with azithromycin than in the ciprofloxacin group.
Dr. Fran Mihaljevic University Hospital for Infectious Diseases, Mirogojska 8, 10 000 Zagreb, Croatia. bfm@bfm.hr
Visnja
V
Skerk
Slavko
S
Schönwald
Ivan
I
Krhen
Arthur
A
Banaszak
Josip
J
Begovac
Jadranka
J
Strugar
Zvonimir
Z
Strapac
Renata
R
Vrsalovic
Jacinta
J
Vukovic
Margita
M
Tomas
D000293:Adolescent; D000328:Adult; D000368:Aged; D017963:Azithromycin / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy*; D002692:Chlamydia trachomatis; D002908:Chronic Disease; D002939:Ciprofloxacin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000382:microbiology / Q000473:pathology; D011472:Prostatitis / Q000188:drug therapy*
D002939:Ciprofloxacin; D017963:Azithromycin