Host-pathogen interactions during apoptosis.
Host pathogen interaction results in a variety of responses, which include phagocytosis of the pathogen, release of cytokines, secretion of toxins, as well as production of reactive oxygen species (ROS). Recent studies have shown that many pathogens exert control on the processes that regulate apoptosis in the host. The induction of apoptosis upon infection results from a complex interaction of parasite proteins with cellular host proteins. Abrogation of host cell apoptosis is often beneficial for the pathogen and results in a successful host invasion. However, in some cases, it has been shown that induction of apoptosis in the infected cells significantly imparts protection to the host from the pathogen. There is a strong correlation between apoptosis and the host protein translation machinery: the pathogen makes all possible efforts to modify this process so as to inhibit cell suicide and ensure that it can survive and, in some cases, establish latent infection. This review discusses the significance of various pathways/steps during virus-mediated modulation of host cell apoptosis.
Laboratory of Molecular and Cellular Biology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500 076, India. director@www.cdfd.org.in
Seyed E
SE
Hasnain
Rasheeda
R
Begum
K V A
KV
Ramaiah
Sudhir
S
Sahdev
E M
EM
Shajil
Tarvinder K
TK
Taneja
Manjari
M
Mohan
M
M
Athar
Nand K
NK
Sah
M
M
Krishnaveni
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D016367:Baculoviridae / Q000502:physiology; D018384:Oxidative Stress; D014176:Protein Biosynthesis; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D014777:Virus Diseases / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D018406:Virus Physiological Phenomena
D017382:Reactive Oxygen Species