Familiality in simple and complex disease.
Establishing the existence of a genetic contribution to disease is the first step in identifying the underlying gene defect(s). This can present a considerable challenge, particularly in diseases where the genetic contribution is complex in nature. Clinically well-characterized cohorts and large inter-institutional collaborations will be required to identify genes involved in complex disease.
Singleton
Andrew
A
Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 10 Room 6C103, 9000 Rockville Pike, Bethesda, MD 20892 USA. singleta@mail.nih.gov
D005190:Family; D030342:Genetic Diseases, Inborn / Q000145:classification / Q000235:genetics*; D006801:Humans