Rubella immunoglobulin G antibody titers in children with seizures.
The third National Health and Nutrition Examination Survey was utilized to assess serum rubella immunoglobulin G antibody titers in a representative sample of American children. Antibody titers were significantly lower in children with a history of seizures and in children treated for seizures compared to unaffected children, after adjustment for age, ethnicity, residence, and region (P=0.022 and 0.029, respectively). Children with the lowest antibody titers were non-Hispanic whites who had a history of seizures. The percentage of US adolescents and young adults with a history of seizures that may have insufficient immunity to rubella is estimated to be 14-50%.
Patient Safety Enhancement Program, University of Michigan, 300 North Ingalls, Suite 7E07, Ann Arbor, MI 48109-0429, USA. maryroge@umich.edu
Mary A M
MA
Rogers
Rosha C
RC
McCoy
D000293:Adolescent; D002648:Child; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D016017:Odds Ratio; D012409:Rubella / Q000150:complications / Q000453:epidemiology / Q000276:immunology*; D012410:Rubella Syndrome, Congenital / Q000453:epidemiology / Q000276:immunology; D012640:Seizures / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D014481:United States / Q000453:epidemiology
D007074:Immunoglobulin G