Hepatoprotective phenolic constituents of Rhodiola sachalinensis on tacrine-induced cytotoxicity in Hep G2 cells.
Two hepatoprotective phenolic compounds, kaempferol (2) and salidroside (4), were isolated from the roots of Rhodiola sachalinensis together with two inactive compounds cinnamyl alcohol (1) and daucosterol (3) based on the hepatoprotective activity against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC(50) values of compounds 2 and 4 were 33.5 and 51.3 micro m, respectively. Silybin as a positive control showed an EC(50) value of 68.4 micro m.
MRRC, Wonkwang University, Iksan 570-749, Korea.
Eun-Kyung
EK
Song
Jung-Hwan
JH
Kim
Jung-Sik
JS
Kim
Hyun
H
Cho
Ji-Xing
JX
Nan
Dong-Hwan
DH
Sohn
Gun-Il
GI
Ko
Hyuncheol
H
Oh
Youn-Chul
YC
Kim
D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D044949:Kaempferols; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D029771:Rhodiola; D013619:Tacrine / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D005419:Flavonoids; D005960:Glucosides; D044949:Kaempferols; D010636:Phenols; D010936:Plant Extracts; D013619:Tacrine; C006552:kaempferol; C009172:rhodioloside