B7-H1 pathway and its role in the evasion of tumor immunity.
B7-H1 is a recently identified member of the B7 family molecules. Upon ligation to its receptors on T cells it regulates activation and differentiation of T cells. B7-H1 preferentially costimulates IL-10 production in resting T cells and further induces the apoptosis of activated T cells. PD-1 is a receptor of B7-H1 and is shown to mediate the inhibition of activated T cell response, presumably by inhibiting cell cycle progression. The expression of B7-H1 protein is limited to macrophage lineage of cells in normal tissues, although its mRNA transcription is found in a broad range of tissues. In contrast, B7-H1 is abundant in various human cancers. The tumor-associated B7-H1 increases apoptosis of antigen specific T cells, leading to growth of immunogenic tumor growth in vivo. Current data suggest that B7-H1 regulates the organ-specific tolerance in normal tissue and may contribute to immune evasion by cancers. Selective manipulation of B7-H1 pathway thus aids in the design of new regimens in the treatment of human autoimmune disease and the control of malignant cancers.
Department of Immunology, Mayo Medical and Graduate Schools, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
Haidong
H
Dong
Lieping
L
Chen
D015703:Antigens, CD; D018122:B7-1 Antigen / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D060890:B7-H1 Antigen; D001798:Blood Proteins; D003110:Colonic Neoplasms / Q000276:immunology; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D008562:Membrane Glycoproteins; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D010051:Ovarian Neoplasms / Q000276:immunology; D010455:Peptides; D011971:Receptors, Immunologic / Q000502:physiology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology
D015703:Antigens, CD; D018122:B7-1 Antigen; D060890:B7-H1 Antigen; D001798:Blood Proteins; C423236:CD274 protein, human; D008562:Membrane Glycoproteins; D010455:Peptides; D011971:Receptors, Immunologic