Selenium, copper, and zinc concentrations in intestinal cancer tissue and in colon and rectum polyps.
The prospective randomized trial was used to determine Se, Zn, and Cu concentrations in intestinal cancer tissue and colorectal polyp. We also determined the relationship among the trace element levels in cancer tissue, the localization of neoplasms, and the stage of their development. The concentrations of these trace elements were examined in cancer tissue of the colorectum in 67 patients and in the colon and rectum polyps in 42 patients using the total-reflection X-ray fluorescence (TRXRF) method. The mean concentration of Se in colorectal cancer was 0.86 microg/g tissue and was statistically higher than in the case of polyps (0.57 microg/g). The mean concentration of Zn in colorectal cancer was higher than in the polyp (14.8 microg/g and 9.84 microg/g, respectively). The determined average concentration of Cu in colorectal cancer was 3.87 microg/g tissue and was a little lower than the level of this metal in the polyp (3.94 microg/g). There was no difference in the levels of these trace elements depending on the location of the neoplasm and the stage of its development. Also, there was no difference between the concentrations of these trace elements in the cancer tissue of malignant and benign tumors after taking into consideration the sex and age of patients. During the examination, we determined significantly higher concentrations of only selenium and zinc in the cancer tissue and not in the polyp. The level of copper was lower in a malignant tumor than in a benign one.
Department of General Surgery, Silesian Medical Academy, Bytom, Poland.
Marek
M
Kucharzewski
Janusz
J
Braziewicz
Urszula
U
Majewska
Stanislaw
S
Gózdz
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003111:Colonic Polyps / Q000378:metabolism* / Q000473:pathology; D003300:Copper / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000378:metabolism* / Q000473:pathology; D011446:Prospective Studies; D012002:Rectal Diseases / Q000378:metabolism* / Q000473:pathology; D012643:Selenium / Q000032:analysis / Q000378:metabolism*; D013052:Spectrometry, X-Ray Emission; D015032:Zinc / Q000032:analysis / Q000378:metabolism*
D003300:Copper; D012643:Selenium; D015032:Zinc