Atrophic and regenerative changes in rabbit mimic muscles after lidocaine and bupivacaine application.
Destruction and denervation atrophy in skeletal muscles caused by the injection of local anaesthetics was investigated by injecting lidocaine or bupivacaine around the rabbit facial nerve to produce facial paralysis. Animals were then sacrificed at 2, 4, 6, and 8 weeks post-injection, and changes in mimic muscle tissue were assessed at each stage by light microscopy and electron microscopy. Atrophic changes were observed at 2-6 weeks after injection, and regeneration started at 6-8 weeks. Compared to bupivacaine, lidocaine caused more dramatic atrophic changes and was associated with slower muscle regeneration.
Department of Anatomy, Gazi University School of Medicine, Besevler, Ankara, Turkey. diamondcigdem@hotmail.com
E
E
Calgüner
R
R
Gözil
D
D
Erdoğan
I
I
Kurt
S
S
Keskil
C
C
Elmas
H
H
Sabuncuoğlu
D000779:Anesthetics, Local / Q000009:adverse effects*; D000818:Animals; D002045:Bupivacaine / Q000009:adverse effects; D005154:Facial Nerve / Q000187:drug effects; D005260:Female; D008012:Lidocaine / Q000009:adverse effects; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000294:innervation / Q000473:pathology; D009133:Muscular Atrophy / Q000139:chemically induced* / Q000473:pathology; D009410:Nerve Degeneration / Q000139:chemically induced* / Q000473:pathology; D009416:Nerve Regeneration / Q000187:drug effects*; D011817:Rabbits
D000779:Anesthetics, Local; D008012:Lidocaine; D002045:Bupivacaine