Caveolin-I overexpression is a favourable prognostic factor for patients with extrahepatic bile duct carcinoma.
Extrahepatic bile duct carcinoma (EBDC) is a malignancy well known for its poor prognosis. Some clinicopathological prognostic markers have been proposed, but genetic factors have not been well investigated. We have examined expression patterns of caveolin-1, which has been shown to function as a tumour suppressor in vitro, in EBDC using immunohistochemistry. Normal tissues adjacent to the tumour cells did not show immunoreactivity for caveolin-1. A total of 22 of the 60-carcinoma tissue samples (36.7%) studied were positive for caveolin-1. Caveolin-1 immunostaining negatively correlated with the patient's age and pathological T factor (pT) in a statistically significant manner. Multivariate analysis using Cox's proportional hazards model identified caveolin-1 expression as an independent positive prognostic factor. Thus, our study suggests that caveolin-1 expression may be a useful prognostic marker for EBDC.
Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
S
S
Murakami
M
M
Miyamoto
Y
Y
Hida
Y
Y
Cho
A
A
Fukunaga
T
T
Oshikiri
K
K
Kato
T
T
Kurokawa
M
M
Suzuoki
Y
Y
Nakakubo
K
K
Hiraoka
T
T
Itoh
T
T
Shinohara
T
T
Morikawa
O
O
Okushiba
S
S
Kondo
H
H
Katoh
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000098:blood supply / Q000473:pathology*; D017734:Bile Ducts, Extrahepatic; D002277:Carcinoma / Q000098:blood supply / Q000473:pathology*; D051242:Caveolin 1; D022461:Caveolins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D011379:Prognosis; D016019:Survival Analysis; D013997:Time Factors
C495540:CAV1 protein, human; D051242:Caveolin 1; D022461:Caveolins