Flow-injection determination of ornidazole by chemiluminescence detection based on a luminol-ferricyanide reaction.
A flow-injection analysis (FIA) with a chemiluminescence detection method was developed for the determination of ornidazole based on the inhibition intensity of chemiluminescence from the luminol-ferricyanide system. Under the condition of 1.0 x 10(-3) mol/L luminol and 5.0 x 10(-6) mol/L potassium ferricyanide, the response to the concentration of omidazole is linear from 0.2 microg ml(-1) to 10 microg ml(-1), and a detection limit of 0.05 microg ml(-1) can be obtained. This method has been successfully applied to the determination of omidazole in pharmaceutical preparations.
Lv
Yi
Y
Institute of Analytical Science, Department of Chemistry, Southwest Normal University, Beibei, Chongqing 400715, PR China.
Zhang
Zhujun
Z
He
Deyong
D
Hu
Yufei
Y
D000890:Anti-Infective Agents / Q000032:analysis*; D005292:Ferricyanides / Q000737:chemistry*; D017022:Flow Injection Analysis; D008163:Luminescent Measurements; D008165:Luminol / Q000737:chemistry*; D009950:Ornidazole / Q000032:analysis*; D012972:Sodium Hydroxide / Q000737:chemistry
D000890:Anti-Infective Agents; D005292:Ferricyanides; C007931:hexacyanoferrate III; D012972:Sodium Hydroxide; D008165:Luminol; D009950:Ornidazole