Serum zinc and alkaline phosphatase values in pediatric bone marrow transplantation patients.
Zinc (Zn) plays an important role in the maintenance of immune functions, including cellular/humoral immunity, and in the prevention of oxidative injury. Therefore, the maintenance of a normal Zn status may be important in bone marrow transplantation (BMT) patients. Serum Zn levels were determined in 35 children during the BMT period. In addition, as Zn-related factors, serum Cu levels and alkaline phosphatase (AP) activity were also measured. There was a significant decrease in Zn and AP values during the immediate post-transplant period (lowest at day +7) when compared to pre-BMT levels (p <.01). The patients who developed hypozincemia were more likely to be transplanted for a diagnosis of malignant disorder and were younger, and adverse events appeared to occur more frequently. This preliminary study suggests that maintaining a normal Zn status may be important in BMT patients and that Zn deficiency may be a risk factor for adverse events.
Uckan
D
D
Hacettepe University Children's Hospital, Bone Marrow Transplantation Unit, Ankara, Turkey. duckan@hacettepe.edu.tr
Cetin
M
M
Dincer
N
N
Kalkan
G
G
Tuncer
M
M
Tezcan
I
I
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003300:Copper / Q000097:blood; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D015032:Zinc / Q000097:blood*
D015415:Biomarkers; D003300:Copper; D000469:Alkaline Phosphatase; D015032:Zinc