Predicting 12-month mortality for persons with dementia.
OBJECTIVE
We develop and test a model of 12-month mortality among persons (N=3858) with organic dementia.


METHODS
Data are from caregiver interviews and claims records for persons enrolled in the Medicare Alzheimer's Disease Demonstration Evaluation. Information covers the year prior to enrollment through 36 months. We used Proportional hazards models to predict time to death. We estimated two starting points: first, the date of randomization, and second, the date of maximum difficulty in performing two or more activities of daily living (ADLs).


RESULTS
The final model includes age, gender, ADL difficulty, medical conditions, prior year hospitalizations, and whether a daughter was the primary caregiver. We combined hazard ratios to produce a cumulative mortality risk score. Model discrimination is reasonable for both models (c statistics of.72 and.69, respectively), and calibration tests were nonsignificant.


CONCLUSIONS
The model's efficiency, as measured by the ratio of false positives (those predicted to die, but who lived) to true positives (those predicted to die and who did die) ranged from fewer than 1:1 to more than 4:1 as the model's sensitivity increased. This ratio was lower in the two or more ADL difficulty model. A validation test of the prediction model found comparable sensitivity and specificity (c statistic of.69) to the reference model.
Newcomer
Robert
R
Departments of Social & Behavioral Science, University of California, San Francisco, CA 94118, USA. rjn@itsa.ucsf.edu
Covinsky
Kenneth E
KE
Clay
Ted
T
Yaffe
Kristine
K
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000401:mortality*; D017028:Caregivers / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008329:Managed Care Programs / Q000706:statistics & numerical data; D006278:Medicare / Q000706:statistics & numerical data; D008609:Mental Status Schedule / Q000706:statistics & numerical data; D015233:Models, Statistical; D016016:Proportional Hazards Models; D011594:Psychometrics; D012306:Risk; D018570:Risk Assessment; D016019:Survival Analysis; D014481:United States