Multivariate analysis of risk factors for development of duodenal ulcer in Helicobacter pylori-infected patients.
BACKGROUND
Although Helicobacter pylori is a significant etiologic factor of peptic ulcer disease, it remains unknown why ulcers develop only in the minority of infected individuals.


OBJECTIVE
The aim of this cross-sectional study was to evaluate the association between the presence of duodenal ulcer in H. pylori-infected patients and different risk factors.


METHODS
A total of 122 H. pylori-infected patients were enrolled; 79 had duodenal ulcer and 43 gastritis. Univariate analysis was conducted using either Fisher's exact test or exact Cochrane-Armitage trend test. In multivariate analysis the logistic model was used.


RESULTS
Univariate analysis indicated six factors (male sex, smoking, antral H. pylori density, CAGA presence in antrum, and VACA s1a presence in antrum and corpus). Four factors (sex, smoking-alcohol index, H. pylori density index, and CAGA index) were found to be significant in multivariate analysis. The best model predicting duodenal ulcer included male sex, smoking, presence of H. PYLORI on histopathology in antrum and CAGA presence in corpus.


CONCLUSIONS
Although several risk factors were significantly associated with duodenal ulcer, we failed in the identification of either a single risk factor or a set of factors that can unequivocally differentiate patients with ulcer from those with gastritis.
Regula
Jaroslaw
J
Department of Gastroenterology, Medical Center for Postgraduate Education, Warsaw, Poland.
Hennig
Ewa
E
Burzykowski
Tomasz
T
Orlowska
Janina
J
Przytulski
Krzysztof
K
Polkowski
Marcin
M
Dziurkowska-Marek
Anna
A
Marek
Tomasz
T
Nowak
Andrzej
A
Butruk
Eugeniusz
E
Ostrowski
Jerzy
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial / Q000032:analysis; D001426:Bacterial Proteins / Q000032:analysis; D003430:Cross-Sectional Studies; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D005773:Gastroscopy; D005838:Genotype; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D016480:Helicobacter pylori / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors; D012737:Sex Factors
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori