Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.
ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein), ABCC1 (MRP1), ABCC2 (MRP2, cMOAT), and ABCG2 (BCRP, MXR, ABCP) are also known to influence oral absorption and disposition of a wide variety of drugs. As a result, the expression levels of these proteins in humans have important consequences for an individual's susceptibility to certain drug-induced side effects, interactions, and treatment efficacy. Naturally occurring variants in ABC transporter genes have been identified that might affect the function and expression of the protein. This review focuses on recent advances in the pharmacogenomics of ABC transporters, and discusses potential implications of genetic variants for the chemotherapeutic treatment of cancer.
Sparreboom
Alex
A
Clinical Pharmacology Research Core, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Danesi
Romano
R
Ando
Yuichi
Y
Chan
Juliana
J
Figg
William D
WD
D018528:ATP-Binding Cassette Transporters / Q000145:classification / Q000235:genetics* / Q000494:pharmacology; D004358:Drug Therapy / Q000639:trends*; D015870:Gene Expression / Q000187:drug effects / Q000235:genetics; D019450:Genes, MDR / Q000187:drug effects / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D000089762:Multidrug Resistance-Associated Protein 2; D009369:Neoplasms / Q000188:drug therapy*; D010597:Pharmacogenetics / Q000639:trends*; D009626:Terminology as Topic
C000715087:ABCC2 protein, human; D018528:ATP-Binding Cassette Transporters; D000089762:Multidrug Resistance-Associated Protein 2