Risperidone reduces limited access alcohol drinking in alcohol-preferring rats.
An atypical antipsychotic drug risperidone reduced ethanol drinking of ethanol-preferring Alko, Alcohol (AA) rats in a limited access paradigm. Its effect was transient at a dose known to preferentially antagonize the 5-HT(2) receptors (0.1 mg/kg, s.c.), but long-lasting when the dose was increased to 1.0 mg/kg that also blocks dopamine D(2) receptors. Risperidone also reduced dose-dependently locomotor activity and limited access saccharin intake of the AA rats, indicating that its effect on ethanol drinking was not selective. Risperidone at 0.1 mg/kg given before four successive daily ethanol-drinking sessions significantly reduced the ethanol intake. These data from an animal model of high ethanol intake suggest that risperidone should be tested in various populations of alcoholics for reducing ethanol consumption.
Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
Kimmo
K
Ingman
Aapo
A
Honkanen
Petri
P
Hyytiä
Matti O
MO
Huttunen
Esa R
ER
Korpi
D000428:Alcohol Drinking / Q000517:prevention & control*; D000437:Alcoholism / Q000188:drug therapy; D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D065127:Dopamine D2 Receptor Antagonists; D004305:Dose-Response Relationship, Drug; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D018967:Risperidone / Q000008:administration & dosage / Q000494:pharmacology*; D012439:Saccharin; D012646:Self Administration; D058830:Serotonin 5-HT2 Receptor Antagonists
D014150:Antipsychotic Agents; D065127:Dopamine D2 Receptor Antagonists; D058830:Serotonin 5-HT2 Receptor Antagonists; D012439:Saccharin; D018967:Risperidone