The role of laminin in embryonic cell polarization and tissue organization.
Genetic analyses have revealed that members of the laminin glycoprotein family are required for basement membrane assembly and cell polarization, with subsequent effects on cell survival and tissue organization during metazoan embryogenesis. These functions depend upon the cooperation between laminin polymerization and cell anchorage mediated via interactions with beta1-integrins, dystroglycan, and other cell surface receptors.
Li
Shaohua
S
Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Edgar
David
D
Fässler
Reinhard
R
Wadsworth
William
W
Yurchenco
Peter D
PD
D000818:Animals; D017209:Apoptosis; D001485:Basement Membrane / Q000166:cytology / Q000196:embryology; D002448:Cell Adhesion; D016764:Cell Polarity; D004847:Epithelial Cells / Q000166:cytology; D007797:Laminin / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000648:ultrastructure
D007797:Laminin