High-dose methylprednisolone treatment of hepatic veno-occlusive disease in a child with Wilms tumor.
Veno-occlusive disease (VOD) is a rare complication of chemotherapy in children with cancer. In the literature successful treatment of severe VOD has not been well determined. The authors report a 5-year-old boy with Willms tumor whose condition was complicated with VOD while receiving chemotherapy. He was treated successfully with high-dose methylprednisolone. After therapy, the clinical signs of VOD, such as abdominal ascites, oliguria, and jaundice, disappeared without any adverse effects of therapy.
Department of Pediatric Oncology, Hacettepe University, Institute of Oncology, Ankara, Turkey. cakyuz@hacettepe.edu.tr
Canan
C
Akyüz
Kudret
K
CaClar
Suna
S
Emir
Münevver
M
Büyükpamukçu
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002675:Child, Preschool; D005938:Glucocorticoids / Q000008:administration & dosage*; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D009396:Wilms Tumor / Q000188:drug therapy / Q000473:pathology*
D005938:Glucocorticoids; D008775:Methylprednisolone