Studies on gynaecological hydrophilic lactic acid preparations. Part 5: The use of Eudragit E-100 as lactic acid carrier in intravaginal tablets.
Intravaginal tablets based on hydrophilic methylcellulose and containing lactic acid complexed with Eudragit E-100 undergo deformation under standard conditions. The high flow--limit of gel originating from the tablets as well as its dynamic viscosity should enable durability of this dosage form on the vaginal mucosa. By selecting either 1 : 1 or 2 : 1 ratios of lactic acid to Eudragit E-100 it is possible to obtain tablets that disintegrate into a gelform at pH 3.8-4.4, i.e. the pH remains within the physiological range. Increasing the amount of lactic acid in the complex in relation to the polymer to a 4:1 ratio results in gels with a lower pH while possessing an acid reserve that can neutralize the excess of alkali present in severe vaginal infections.
Małolepsza-Jarmołowska
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Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University, Wrocław, Poland.
Kubis
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Hirnle
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D000282:Administration, Intravaginal; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004337:Drug Carriers; D005079:Excipients; D005780:Gelatin; D005782:Gels; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008689:Methacrylates; D008747:Methylcellulose; D008768:Methylmethacrylates; D013488:Suppositories; D014783:Viscosity
D004337:Drug Carriers; D005079:Excipients; D005782:Gels; D008689:Methacrylates; D008768:Methylmethacrylates; D013488:Suppositories; C102808:Eudragit-E; D019344:Lactic Acid; D005780:Gelatin; D008747:Methylcellulose