The role of vaccine in controlling hepatitis A epidemics.
We report the conduct and results of a review of recent literature to describe various types of epidemics and outbreaks in Italy or countries with similar epidemiological profiles and to assess vaccine use in outbreak situations. We identified three scenarios most likely to occur in Italy: outbreaks occurring in small closed communities (nursery or a primary school), outbreaks in communities of limited dimensions (small towns or villages) and open community settings in which epidemics occur at regular intervals (person-to-person transmission). In closed communities we recommend vaccination of family members and school personnel living or working in close proximity to the index case as well as classmates. We also recommend vaccination when there is a proof of secondary transmission within the community. In small open communities we recommend vaccination of more susceptible age groups such as children and adolescents. For large open communities the only practicable alternative strategy is vaccination of close family contacts of acute cases couple with non-immunity boosting control measures.
Istituto Superiore di Sanità, Laboratorio di Epidemiologia e Biostatistica, Viale Regina Elena 299, 00161 Rome, Italy. dargenio@iss.it
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D'Argenio
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Adamo
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D004196:Disease Outbreaks; D006506:Hepatitis A / Q000453:epidemiology* / Q000276:immunology* / Q000517:prevention & control; D022362:Hepatitis A Vaccines / Q000627:therapeutic use*; D006801:Humans; D016239:MEDLINE
D022362:Hepatitis A Vaccines