Role of reactive oxygen species in the pathophysiology of human reproduction.
OBJECTIVE
To summarize the role of reactive oxygen species (ROS) in the pathophysiology of human reproduction.


METHODS
Review of literature.


METHODS
Fertility research center and obstetrics and gynecology department in a tertiary care facility.


RESULTS
ROS plays an essential role in the pathogenesis of many reproductive processes. In male-factor infertility. oxidative stress attacks the fluidity of the sperm plasma membrane and the integrity of DNA in the sperm nucleus. Reactive oxygen species induced DNA damage may accelerate the process of germ cell apoptosis, leading to the decline in sperm counts associated with male infertility. ROS mediated female fertility disorders share many pathogenic similarities with the ones on the male side. These similarities include a potential role in the pathophysiology of endometriosis and unexplained infertility. High follicular fluid ROS levels are associated with negative IVF outcomes, particularly in smokers. Moreover, oxidative stress may be responsible in hydrosalpingeal fluid mediated embryotoxicity as well as poor in vitro embryonic development.


CONCLUSIONS
High levels of ROS are detrimental to the fertility potential both in natural and assisted conception states.
Center for Advanced Research in Human Reproduction, Infertility, and Sexual Function, Urological Institute and Department of Obstetrics-Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. agarwaa@ccf.org
Ashok
A
Agarwal
Ramadan A
RA
Saleh
Mohamed A
MA
Bedaiwy
D004249:DNA Damage / Q000502:physiology; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology*; D007248:Infertility, Male / Q000503:physiopathology*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D011247:Pregnancy; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013094:Spermatozoa / Q000473:pathology / Q000502:physiology
D017382:Reactive Oxygen Species