[Hypoalbuminemia and invalidating edema in an elderly subject: treatment with parenteral albumin infusion].
Many factors can lead to edema. Hypoalbuminemia and the inability of the renal distal tubule to excrete salt are a common cause of edema, that can be due to a defect of albumin synthesis or malnutrition, kidney disease, protein-losing enteropathy, or increased protein catabolism. Hypoalbuminemia is frequent amongst elderly people. Its prevalence ranges from 4% to 50% depending on whether they live at home or in hospice. In normal circumstances, albumin has a double function to maintain oncotic pressure and to transport endogenous or exogenous substances. Lack of albumin is thus responsible for numerous pathological states. In this article, we report two clinical observations in patients aged over 65, suffering from generalized, highly invalidating edema, with low albumin states due to malnutrition. A rapid long-term recovery was observed after administrating albumin, and produced a far better quality of life for the patients. The clinical results obtained following this specific indication warrant further research work to verify their scientific validity on a larger scale.
Novella
Jean-Luc
JL
Service de Médecine Interne à Orientation Gériatrique, M4B, Hôpital Sébastopol, 49, rue Sébastopol, 51092 Reims Cedex. jlnovella@chu-reims.fr
Jochum
Charbanou
C
Kack
Simon
S
Garron
Sophie
S
Blanchard
François
F
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000008:administration & dosage / Q000627:therapeutic use; D004232:Diuretics / Q000008:administration & dosage / Q000627:therapeutic use; D004487:Edema / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D034141:Hypoalbuminemia / Q000188:drug therapy / Q000209:etiology; D008297:Male; D009748:Nutrition Disorders / Q000150:complications; D009747:Nutritional Physiological Phenomena; D011788:Quality of Life; D013997:Time Factors
D000418:Albumins; D004232:Diuretics