[Comparison of quality of life in patients with advanced ovarian cancer treated with intraperitoneal or intravenous cisplatin and cyclophosphamide as a second line of therapy].
OBJECTIVE
The study aimed to compare the effect of second line intravenous and intraperitoneal chemotherapy on physical and psychological aspects of quality of life in patients with advanced ovarian cancer.


METHODS
Quality of life was measured with EORTC QLQ-C30 (version 3.0) questionnaire. 42 sample patients with histologically confirmed diagnosis of advanced epithelial ovarian cancer treated with second line intravenous or intraperitoneal chemotherapy were included in the study.


RESULTS
Higher score of global quality of life and less side-effects of chemotherapy were observed in the group of patients treated with intraperitoneal chemotherapy. In this group constipation and dyspnoea were less common.


CONCLUSIONS
Intraperitoneal chemotherapy has less negative influence on quality of life than intravenous drug delivery.
Kliniki Ginekologii Instytutu Połoznictwa i Chorób Kobiecych AM w Gdańsku.
Ewa
E
Majdak
Liliana
L
Krasińska
Piotr
P
Mielcarek
Juliusz
J
Kobierski
Joanna
J
Kozaka
Tomasz
T
Milczek
Janusz
J
Emerich
D000223:Adaptation, Psychological; D000328:Adult; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D007263:Infusions, Parenteral / Q000379:methods; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000523:psychology; D011788:Quality of Life; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors; D016387:Women's Health
D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide; D002945:Cisplatin