Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease.
There is increasing evidence that immune mechanisms are involved in the pathogenesis of Alzheimer's disease (AD). Recently, polymorphisms of the interleukin (IL)-1 and IL-6 genes were found to be associated with late-onset AD. The immunoregulatory IL-10 downregulates synthesis of pro-inflammatory cytokines such as IL-1. Current evidence suggests that some polymorphisms in the IL-10 promoter may have functional effects on IL-10 transcription. A total of 406 German AD patients (mean age 70.2+/-10.0 years, range 50-95 years, 42% female) and 251 unrelated non-demented control subjects (mean age 66.8+/-10.6 years, range 50-93 years, 38% female) were investigated for the presence of three polymorphisms in the IL-10 promoter region (-1087A/G, -824C/T, -597C/A). No significant differences in the allelic distribution of the analyzed IL-10 polymorphisms have been found between AD patients and controls. We conclude that polymorphisms in the IL-10 promoter region do not increase the risk of developing AD.
Department of Neurology, Friedrich-Wilhelms University, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany.
Candan
C
Depboylu
Yansheng
Y
Du
Ulrich
U
Müller
Alexander
A
Kurz
Reinhilde
R
Zimmer
Matthias
M
Riemenschneider
Thomas
T
Gasser
Wolfgang H
WH
Oertel
Thomas
T
Klockgether
Richard C
RC
Dodel
Wolfgang H
WH
Oertelf
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D015536:Down-Regulation; D005260:Female; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012307:Risk Factors
D016753:Interleukin-10