Fibrin sealants and platelet preparations in bone and periodontal healing.
Fibrin sealants and platelet concentrates have been used alone or in association with bone substitutes to promote bone healing in orthopedic and oral surgery. Commercial fibrin sealants are homologous plasma-derived products that mimic the last step of a coagulation cascade, leading to a fibrin clot. They are used for topical hemostasis and tissue sealing and as melting agents for particulate bone substitutes. Infectious risk led to the development of autologous fibrin sealants from the patient's own plasma. However, their fabrication results in less reproducible or less satisfactory rheologic properties. The use of autologous products with high platelet concentrations, such as platelet-rich plasma, platelet concentrate, and platelet gels, has recently been suggested for combining the fibrin sealant properties with the growth factor effects of platelets. We describe the characteristics and limitations of fibrin sealants (commercial/autologous) and platelet preparations and review their effects on bone and periodontal healing as reported in experimental studies and clinical trials.
Soffer
Emmanuel
E
Laboratoire de biomécanique biomateriaux articulaires UPRES-CNRS 7052, Faculté de Medecine Lariboisière-Saint Louis, 10, Avenue de Verdun, 75010 Paris, France.
Ouhayoun
Jean Pierre
JP
Anagnostou
Fani
F
D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use; D001842:Bone and Bones / Q000601:surgery*; D015718:Fibrin Tissue Adhesive / Q000737:chemistry / Q000627:therapeutic use*; D006133:Growth Substances / Q000627:therapeutic use; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D010519:Periodontium / Q000601:surgery*; D017713:Platelet Transfusion / Q000379:methods; D014014:Tissue Adhesives / Q000737:chemistry / Q000627:therapeutic use*; D014945:Wound Healing
D018786:Bone Substitutes; D015718:Fibrin Tissue Adhesive; D006133:Growth Substances; D006490:Hemostatics; D014014:Tissue Adhesives