Serum concentrations of interleukin-2R (IL-2R), IL-6, IL-8, and tumor necrosis factor alpha in patients with ectopic pregnancy.
OBJECTIVE
To investigate the diagnostic relevance of serum cytokine concentrations in ectopic pregnancy (EP).


METHODS
Cohort study.


METHODS
University hospital.


METHODS
Seventeen women with EP, 22 women with miscarriage, and 33 women with normal intrauterine pregnancy, at comparable stages of gestation.


METHODS
Interleukin (IL)-2 receptor, IL-6, IL-8, and tumor necrosis factor alpha (TNF-alpha) determination by immunoradiometric assay.


METHODS
Serum concentrations of progesterone, beta-hCG, IL-2R, IL-6, IL-8, and TNF-alpha.


RESULTS
Serum levels of IL-6 were higher in women with EP than in those with miscarriage and normal pregnancy. Serum levels of TNF-alpha were higher in women with EP than in those with miscarriage and normal pregnancy. Serum levels of IL-8 were higher in women with EP than in those with miscarriage and normal pregnancy. An IL-8 cutoff of >40 pg/mL predicted EP with a sensitivity of 82.4%, a specificity of 81.8%, and positive and negative predictive values of 58.3% and 93.8%. No difference in serum IL-2R levels was found among the groups.


CONCLUSIONS
Serum IL-8, IL-6, and TNF-alpha concentrations are higher in women with EP than in those with miscarriage and normal pregnancy. Further studies are needed to determine their diagnostic value.
Service de Gynécologie, Hôpital Hôtel-Dieu, Université Broussais-Hôtel-Dieu, Assistance Public des Hôpitaux de Paris, and INSERM U327, Université Paris, Paris, France.
David
D
Soriano
Danielle
D
Hugol
Nhuan Tran
NT
Quang
Emile
E
Darai
D000022:Abortion, Spontaneous / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000097:blood* / Q000000981:diagnostic imaging; D011374:Progesterone / Q000097:blood; D012372:ROC Curve; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D014463:Ultrasonography
D006063:Chorionic Gonadotropin; D015850:Interleukin-6; D016209:Interleukin-8; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D011374:Progesterone