Mitochondrion-targeted apoptosis regulators of viral origin.
During coevolution with their hosts, viruses have "learned" to intercept or to activate the principal signal transducing pathways leading to cell death. A number of proteins from pathophysiologically relevant viruses are targeted to mitochondria and regulate (induce or inhibit) the apoptosis-associated permeabilization of mitochondrial membranes. Such proteins are encoded by human immunodeficiency virus 1, Kaposi's sarcoma-associated herpesvirus, human T-cell leukemia virus-1, hepatitis B virus, cytomegalovirus, and Epstein Barr virus, among others. Within mitochondria, such apoptosis regulators from viral origin can target distinct proteins from the Bcl-2 family and the permeability transition pore complex including the adenine nucleotide translocase, cyclophilin D, the voltage-dependent anion channel, and the peripheral benzodiazepine receptor. Thus, viral proteins can regulate apoptosis at the mitochondrial level by acting on a variety of different targets.
Centre National de la Recherche Scientifique, UMR 8125, Institut Gustave Roussy, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F-94805 Villejuif, France.
Patricia
P
Boya
Thomas
T
Roumier
Karine
K
Andreau
Rosa Ana
RA
Gonzalez-Polo
Naoufal
N
Zamzami
Maria
M
Castedo
Guido
G
Kroemer
D000818:Animals; D017209:Apoptosis; D002463:Cell Membrane Permeability; D007425:Intracellular Membranes / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000502:physiology; D014764:Viral Proteins / Q000494:pharmacology*
D024101:Mitochondrial Proteins; D014764:Viral Proteins