Significance of one pronucleus before fertilization.
OBJECTIVE
To describe a case of primary infertility associated with oocytes having one pronucleus before fertilization on repeated IVF attempts.


METHODS
Case report.


METHODS
A university-based assisted reproduction unit.


METHODS
A 30-year-old woman with primary infertility and oocytes containing one pronucleus before fertilization.


METHODS
Oocyte donation.


METHODS
Pregnancy.


RESULTS
Conceived triplets after transfer of three embryos using donor oocytes.


CONCLUSIONS
This patient's infertility was likely associated with an oocyte abnormality, as evidenced by the premature formation of one pronucleus before fertilization. In the future, more studies on the appearance of a single pronucleus before fertilization will be needed to determine its overall significance on fertility.
Department of Gynecology and Obstetrics, Stanford University Medical Center, Stanford, California 94305-5317, USA. lynnw@stanford.edu
Lynn M
LM
Westphal
Marcus
M
Rosencrantz
Barry
B
Behr
Amin A
AA
Milki
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D008297:Male; D018587:Oocyte Donation; D009865:Oocytes / Q000473:pathology*; D011247:Pregnancy