Biopterin metabolism in patients with malignant syndrome.
We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of the brain from patients with MS. This finding suggested a possible involvement of biopterin metabolism in pathophysiology of MS. This is the first report on biopterin metabolism in the brains of patients with MS.
Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Hiroshi
H
Ichinose
Tamae
T
Ohye
Hitoshi
H
Shinotoh
Kimihito
K
Arai
Shunzo
S
Yamazaki
Eiji
E
Mizuta
Sadako
S
Kuno
Toshiharu
T
Nagatsu
D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000009:adverse effects; D001708:Biopterins / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005260:Female; D006136:GTP Cyclohydrolase / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000378:metabolism; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology / Q000378:metabolism*; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism*; D013375:Substance Withdrawal Syndrome / Q000378:metabolism
D000978:Antiparkinson Agents; D001708:Biopterins; D019798:Neopterin; D006136:GTP Cyclohydrolase