Volume-selective 3D turbo spin echo imaging for vascular wall imaging and distensibility measurement.
OBJECTIVE
To use a volume-selective 3D turbo spin echo (TSE) technique to image the carotid artery wall and measure distensibility.


METHODS
A high-resolution volume-selective 3D TSE sequence has been developed. Volume selection is accomplished by orthogonal gradients for the 90 degrees and 180 degrees excitations and allows a 3D volume of vessel wall to be imaged in a relatively short time. The technique has been developed to allow imaging at any defined phase of the cardiac cycle so that the vascular function and distensibility can be studied.


RESULTS
Scan efficiency is increased by the reduced phase encode field of view (FOV) (k(y) steps) by the use of selective volume excitation. Significantly more slices (k(z) phase encode steps) for vessel coverage can be acquired with the same scan time as that of the conventional sequence while maintaining signal-to-noise ratio (SNR) levels. The practical value of the technique was demonstrated on 10 normal subjects with high-resolution vessel distensibility measurements of the carotid arteries.


CONCLUSIONS
A volume-selective TSE method has been used for carotid artery wall imaging and measurement of distensibility in normal subjects. Larger coverage of the vessel, and therefore more information for clinical diagnostics, was achieved with the same overall scan time with an SNR comparable to that of 2D full FOV images.
Crowe
Lindsey A
LA
Magnetic Resonance Unit, Imperial College and Royal Brompton Hospital, London, UK. l.crowe@rbh.nthames.nhs.uk
Gatehouse
Peter
P
Yang
Guang Zhong
GZ
Mohiaddin
Raad H
RH
Varghese
Anitha
A
Charrier
Clare
C
Keegan
Jennifer
J
Firmin
David N
DN
D000328:Adult; D002340:Carotid Artery Diseases / Q000175:diagnosis*; D003971:Diastole; D005260:Female; D006801:Humans; D007089:Image Enhancement; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged