Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Glucagon in tricyclic overdose.
A short cut review was carried out to establish whether the addition of glucagon to standard treatments improves clinical outcome in patients who have taken an overdose of tricyclic antidepressants. Altogether 31 papers were found using the reported search, of which three presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results, and study weaknesses of these best papers are tabulated. A clinical bottom line is stated.
Department of Emergency Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
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Teece
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Hogg
D000328:Adult; D000639:Amitriptyline / Q000506:poisoning*; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D062787:Drug Overdose; D004630:Emergencies; D019317:Evidence-Based Medicine; D005260:Female; D005934:Glucagon / Q000627:therapeutic use*; D006801:Humans
D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D005934:Glucagon