[The role of nitric oxide in the pathogenesis of central nervous system damages].
The review considers a role of the modulator nitric oxide--in the pathogenesis of central nervous system damages, first of all, of ischemic type. Multiple nitric oxide influences on cerebral blood flow, oxidant stress system and intracellular signaling mechanisms are shown. Investigation of nitric oxide system opens new perspectives for a therapy of acute and chronic brain ischemia.
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Gorbachev
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Kovalev
D001921:Brain / Q000098:blood supply* / Q000378:metabolism; D001930:Brain Injuries / Q000209:etiology / Q000378:metabolism; D002545:Brain Ischemia / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology
D009569:Nitric Oxide; D019001:Nitric Oxide Synthase