Modeling network dynamics: the lac operon, a case study.
We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description (molecular, cellular, and that of cell population) into a single model, which seems to capture many experimental aspects of the system.
The Rockefeller University, 1230 York Avenue, Box 34, New York, NY 10021, USA. vilarj@rockefeller.edu
José M G
JM
Vilar
Călin C
CC
Guet
Stanislas
S
Leibler
D000818:Animals; D019295:Computational Biology / Q000379:methods* / Q000639:trends; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007763:Lac Operon / Q000235:genetics*; D007785:Lactose / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D017711:Nonlinear Dynamics
D007785:Lactose