Water-soluble porphyrins appending platinum(II) complexes as binders for synthetic nucleic acid polymers.
Water-soluble porphyrins containing four platinum(II) complexes per molecule, [5alpha,10beta,15alpha,20beta-tetrakis(2-trans-(alpha,beta,alpha,beta-trans-Pt) and cis-(alpha,beta,alpha,beta-cis-Pt) [PtCl(NH(3))(2)]N-2-aminophenylporphyrin)], were synthesized and characterized. The binding of synthetic nucleotide polymers (poly(dG)-poly(dC), poly(dA)-poly(dT)) to the porphyrins was examined spectrophotometrically in aqueous solution. UV-vis spectral data suggested that these porphyrins bind to the nucleic acids by coordinative and Coulomb interactions.
Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan. h-munakata@hokuriku-u.ac.jp
Hiroki
H
Munakata
Hiroyasu
H
Imai
Shigeo
S
Nakagawa
Atsuko
A
Osada
Yoshio
Y
Uemori
D009841:Oligonucleotides / Q000737:chemistry*; D009944:Organoplatinum Compounds / Q000737:chemistry*; D011066:Poly C / Q000737:chemistry; D011068:Poly G / Q000737:chemistry; D011067:Poly dA-dT / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D009841:Oligonucleotides; D009944:Organoplatinum Compounds; D011166:Porphyrins; D011068:Poly G; D011067:Poly dA-dT; D011066:Poly C