Acenocoumarol is not a safe alternative for anticoagulation in phenprocoumon-induced hepatic failure. Report of two cases.
Acenocoumarol has been proposed repeatedly as a safe alternative drug regimen for oral anticoagulation in patients who have suffered phenprocoumon-induced fulminant hepatic failure. The current report describes 2 patients with phenprocoumon-induced hepatic failure, necessitating liver transplantation in 1 case, who showed recurrence of liver damage when oral anticoagulation with acenocoumarol was attempted. Thus, acenocoumarol may not be a safe therapeutic alternative for patients who survived severe phenprocoumon-induced hepatotoxicity.
Neef
Markus
M
Department of General Internal Medicine, University of Bonn, Bonn, Germany. m.neef@uni-bonn.de
Kerekes
Zsuzsanna
Z
Fischer
Hans-Peter
HP
Sauerbruch
Tilman
T
Spengler
Ulrich
U
D000074:Acenocoumarol / Q000009:adverse effects*; D000925:Anticoagulants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D017093:Liver Failure / Q000139:chemically induced* / Q000628:therapy; D008111:Liver Function Tests; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D010644:Phenprocoumon / Q000009:adverse effects*
D000925:Anticoagulants; D000074:Acenocoumarol; D010644:Phenprocoumon