[Development and repair of vessels from bone marrow stem cells in the adult: from biology to clinical practice].
In addition to its role in hematopoiesis, bone marrow appears to be a reservoir of stem cells that can differentiate into components of vessel wall. Upon stimulation by factors such as tissue ischemia, bone marrow stem cells can enter into circulating blood, and incorporate into areas of vascular development. Animal models suggest that bone marrow is a cellular source for tissue repair and/or regeneration. Data from humans, and clinical trials using bone marrow stem cells for the treatment of chronic ischemia in limbs and myocardium, support the view that stem cells may represent a new tool for the treatment of ischemia.
Allaire
E
E
FAMA de Pathologie Vasculaire, Hôpital Tenon, 4, rue de la Chine, 75020 Paris. allaire@club-internet.fr
Boufi
M
M
Smedile
G
G
Schneider
F
F
Pagès
C
C
Guinault
A M
AM
Becquemin
J P
JP
Boudghène
F
F
Vayssairat
M
M
D000328:Adult; D000818:Animals; D001158:Arteries / Q000166:cytology; D001854:Bone Marrow Cells / Q000502:physiology*; D002448:Cell Adhesion; D002454:Cell Differentiation; D015687:Cell Hypoxia; D002465:Cell Movement; D004730:Endothelium, Vascular / Q000166:cytology*; D018507:Gene Expression Regulation, Developmental; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D007511:Ischemia / Q000503:physiopathology / Q000628:therapy; D008648:Mesoderm / Q000166:cytology / Q000378:metabolism; D023421:Models, Animal; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000628:therapy; D018919:Neovascularization, Physiologic / Q000502:physiology*; D039904:Pluripotent Stem Cells / Q000502:physiology*; D012038:Regeneration / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
D006133:Growth Substances