[Dynamic observation of carbofuran on symbolic enzymes in testis of rats].
To examine the effects of carbofuran on the testis of male rats. The activities of beta-glucuronidase (beta-G), glucose-6-phosphate dehydrogenase(G-6-PD) and lactate dehydrogenase isoenzyme-x (LDHx) in serum and testis homogenate were determined for the rats given carbofuran at the dises of 0.3, 1.5 and 3.0 mg/kg orally for 7, 35 and 77 days. The results showed that after 7 days, the activities of beta-G in serum in all exposed groups were lower than those in control (P < 0.05). The activities of beta-G in testis homogenate in 0.3 mg/kg and 3.0 mg/kg were higher or lower than those in control (P < 0.05), respectively. After 77 days, the activities of G-6-PD in serum both in 1.5 mg/kg and 3.0 mg/kg were lower than those in control (P < 0.05). The activities of LDHx in testis homogenate in 3.0 mg/kg were lower than those in control (P < 0.05). It suggested that exposure to carbofuran could testis damage.
Department of Toxicology, Shenyang Medical College, Shenyang 110031, China.
Zhiwen
Z
Duan
Yumin
Y
Zhang
Haishan
H
Li
Jinshan
J
Cui
D000818:Animals; D002235:Carbofuran / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005966:Glucuronidase / Q000097:blood / Q000378:metabolism*; D007306:Insecticides / Q000633:toxicity*; D007527:Isoenzymes / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000201:enzymology*
D007306:Insecticides; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; C409673:lactate dehydrogenase C4; D005954:Glucosephosphate Dehydrogenase; D005966:Glucuronidase; D002235:Carbofuran