[Recent progress in the study of common fusarium mycotoxins on apoptosis of cells].
Fumonisin B1, T-2 toxin, Fusarenon-X and Deoxynivalenol, which are all mycotoxins produced by fusarium, could induce apoptosis of liver cell, kidney cell, gastrointestinal epithelial cell, immunological cells as well as several cell lines of human and animals. The possible mechanisms of apoptosis induction are complicated. Sphingol, p21 gene, protein kinase, CAMP signal system and intracellular Ca2+ level, might be involved in the cellular apoptosis induction by Fusarium mycotoxins.
Institute of Basic Medical Science, Hebei Medical University, Shijiazhuang 050017, China.
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D000818:Animals; D017209:Apoptosis; D002273:Carcinogens / Q000633:toxicity; D037341:Fumonisins / Q000633:toxicity*; D005670:Fusarium / Q000737:chemistry*; D009183:Mycotoxins / Q000633:toxicity; D013605:T-2 Toxin / Q000633:toxicity*
D002273:Carcinogens; D037341:Fumonisins; D009183:Mycotoxins; C056933:fumonisin B1; D013605:T-2 Toxin