Cerebrovascular reactivity in hypertensive and healthy adolescents: TCD with vasodilatory challenge.
BACKGROUND
Adolescent hypertension predicts hypertension and increased cardiovascular morbidity in adulthood. The aim of the present work was to test whether cerebrovascular reactivity to CO2 is altered among hypertensive adolescents.


METHODS
From the population-based cohort of the Debrecen Hypertension Study, 113 hypertensive and 58 normotensive adolescents underwent transcranial Doppler measurements at rest and after 30 seconds of breath holding.


RESULTS
Systolic, mean, and diastolic blood flow velocities were higher among hypertensive individuals at rest. Taking the absolute blood flow velocity parameters into account, after breath holding, only the pulsatility index was significantly higher in the hypertensive group. The percentage change of the different blood flow parameters showed less intensive change in hypertensive teenagers.


CONCLUSIONS
Cerebral vasoreactivity is decreased among hypertensive individuals as compared to healthy controls.
Department of Neurology, 1st Department of Medicine, University of Debrécen, Health and Medical Science Center, Debrecen, Hungary.
Georgios
G
Settakis
Dénes
D
Páll
Csilla
C
Molnár
Dániel
D
Bereczki
László
L
Csiba
Béla
B
Fülesdi
D000293:Adolescent; D001783:Blood Flow Velocity; D002245:Carbon Dioxide / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging*; D008297:Male; D011673:Pulsatile Flow; D018709:Statistics, Nonparametric; D017585:Ultrasonography, Doppler, Transcranial
D002245:Carbon Dioxide