The Na/K pump, Cl ion, and osmotic stabilization of cells.
An equation for membrane voltage is derived that takes into account the electrogenicity of the Na/K pump and is valid dynamically, as well as in the steady state. This equation is incorporated into a model for the osmotic stabilization of cells. The results emphasize the role of the pump and membrane voltage in lowering internal Cl(-) concentration, thus making osmotic room for vital substances that must be sequestered in the cell.
Department of Physiology, University of Pennsylvania School of Medicine, B-701 Richards Building, Philadelphia 19104-6085, USA. carmstro@mail.med.upenn.edu
Clay M
CM
Armstrong
D000818:Animals; D000838:Anions; D002462:Cell Membrane / Q000201:enzymology / Q000502:physiology; D002463:Cell Membrane Permeability / Q000502:physiology*; D002468:Cell Physiological Phenomena; D002712:Chlorides / Q000378:metabolism*; D004594:Electrophysiology; D007700:Kinetics; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000502:physiology*; D009994:Osmolar Concentration; D011898:Ranidae; D015203:Reproducibility of Results; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D000838:Anions; D002712:Chlorides; D000254:Sodium-Potassium-Exchanging ATPase