Expression of H-Y antigen on preimplantation mouse embryos.
The expression of H-Y antigen on preimplantation mouse embryos has been studied by complement dependent cytotoxicity. Embryos at the 8-cell stage were exposed to anti-H-Y and complement and then scored for cell death. Overall, half of the treated embryos were killed, retarded, or contained dead cells. Of those embryos which were not affected by anti-H-Y, 92% were female. In control experiments, neither normal serum plus complement nor complement alone had any specific effect on male embryos. It is concluded, therefore, that the H-Y antigen is present on preimplantation mouse embryos.
Department of Pediatrics, Howard Medical Institute Laboratory, University of California, San Francisco, California 94143, USA.
C J
CJ
Epstein
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Smith
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Travis
D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology; D000918:Antibody Specificity; D001755:Blastocyst / Q000737:chemistry* / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D006182:H-Y Antigen / Q000032:analysis* / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D012737:Sex Factors
D000906:Antibodies; D006182:H-Y Antigen