Social stress affects migration of blood T cells into lymphoid organs.
The effect of social confrontation stress on the normal distribution of blood T cells into lymphoid organs and some other body tissues was studied. Social stress was induced by placing a male Fischer 344 (F334) rat into the home cage of a resident opponent. 51Cr-labeled blood T cells isolated from syngeneic donor, were intravenously injected into recipients immediately before confrontation. The accumulation of 51Cr-labeled T cells in the spleen, mesenteric and cervical lymph nodes 24 h after injection was about 30% lower in socially stressed than in control males. Substantially higher localization was observed in the bone marrow of socially stressed males.
Department of Animal Physiology, University of Bayreuth, 95440 Bayreuth, Germany. volker.stefanski@uni-bayreuth.de
Volker
V
Stefanski
André
A
Peschel
Stefan
S
Reber
D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D002860:Chromium Radioisotopes / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D004291:Dominance-Subordination; D005260:Female; D008168:Lung / Q000166:cytology / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008221:Lymphoid Tissue / Q000166:cytology* / Q000276:immunology; D008297:Male; D008643:Mesentery; D009333:Neck; D051381:Rats; D011916:Rats, Inbred F344; D020318:Rats, Long-Evans; D012931:Social Environment; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013315:Stress, Psychological / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000637:transplantation
D002860:Chromium Radioisotopes; D003345:Corticosterone