Susceptibilities of different Actinobacillus actinomycetemcomitans strains to lactoperoxidase-iodide-hydrogen peroxide combination and different antibiotics.
Actinobacillus actinomycetemcomitans has an important aetiological role in localized juvenile periodontitis and in progressive periodontitis in adults. A. actinomycetemcomitans is found mainly in periodontal pockets but also in whole saliva, a potential transmission medium. It is sensitive to peroxidase-halide systems, but the differences between periodontitis associated clinical isolates and type strains are unclear. The sensitivities of these 2 strain groups to lactoperoxidase (LP)-iodide (I(-))-hydrogen peroxide (H(2)O(2)) combinations were investigated, and the sensitivities were compared with the susceptibilities to four antibiotics. There was great variation between the sensitivities of different strains, but the 2 strain groups responded similarly. The LP (75 microg)-I(-) (100 nmol)-H(2)O(2) (1000 nmol) combination produced a similar degree of inhibition as 2 microg ampicillin. The LP-I(-) system might be a potential antimicrobial agent against A. actinomycetemcomitans transmission via saliva.
Ihalin
Riikka
R
Institute of Dentistry, Turku Immunology Centre and TuBS, University of Turku, Lemminkäisenkatu 2, FIN-20520 Turku, Finland. riikka.ihalin@utu.fi
Pienihäkkinen
Kaisu
K
Lenander
Marianne
M
Tenovuo
Jorma
J
Jousimies-Somer
Hannele
H
D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects* / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D007454:Iodides / Q000494:pharmacology*; D007784:Lactoperoxidase / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D007454:Iodides; D006861:Hydrogen Peroxide; D007784:Lactoperoxidase