Evaluation of feline serum amyloid A (SAA) as an inflammatory marker.
The concentration of feline serum amyloid A (fSAA) was determined by a direct enzyme-linked immunosorbent assay (ELISA) by using fSAA specific monoclonal antibodies, to evaluate the fSAA as an inflammatory marker in cats. The mean concentration +/- standard deviation of fSAA was found to be 0.60 +/- 1.06 microg/m l and 33.65 +/- 67.59 microg/ml in serum samples from normal cats (n=45) and cats (n=312) with various diseases and disorders, respectively. A significant difference (p<0.001) was found between the two groups. It was also found that the concentration of fSAA begins to increase rapidly at approximately 3-6 hr after spay, and increases up to significantly high levels in some disorders, like injury, renal failure, infectious diseases, etc.
Sasaki
Kimikazu
K
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yoshida, Japan.
Ma
Zhiyong
Z
Khatlani
Tanvir S
TS
Okuda
Masaru
M
Inokuma
Hisashi
H
Onishi
Takafumi
T
D000818:Animals; D000911:Antibodies, Monoclonal; D015415:Biomarkers / Q000097:blood; D002371:Cat Diseases / Q000097:blood / Q000175:diagnosis*; D002415:Cats; D003141:Communicable Diseases / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D004751:Enteritis / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D009059:Mouth Diseases / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D051437:Renal Insufficiency / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D000685:Serum Amyloid A Protein / Q000032:analysis* / Q000276:immunology; D014570:Urologic Diseases / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D014947:Wounds and Injuries / Q000097:blood / Q000175:diagnosis / Q000662:veterinary
D000911:Antibodies, Monoclonal; D015415:Biomarkers; D000685:Serum Amyloid A Protein