Severe infusion reaction induced by trastuzumab: a case report.
We report a case of a severe infusion reaction caused by trastuzumab. A 59-year-old woman with metastatic breast cancer was treated with trastuzumab. During the first infusion, initial symptoms such as severe headache and general fatigue developed. Blood pressure fell 90 minutes after these initial symptoms. A collapsed lung was demonstrated by chest X-ray and computed tomography. Steroid therapy was successfully used for these reactions. Careful monitoring of vital signs, examination of the respiratory system, and the use of steroids are recommended for severe infusion reaction.
Department of Medical Oncology, Cancer Institute Hospital, 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo 170-8455, Japan. ktada@jfcr.or.jp
Keiichiro
K
Tada
Yoshinori
Y
Ito
Kiyohiko
K
Hatake
Taeko
T
Okudaira
Jun-ichiro
J
Watanabe
Masahiro
M
Arakawa
Masayo
M
Miyazato
Tetsuya
T
Irie
Nobuyuki
N
Mizunuma
Syunji
S
Takahashi
Keisuke
K
Aiba
Noboru
N
Horikoshi
Fujio
F
Kasumi
D000707:Anaphylaxis / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology / Q000628:therapy; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged; D001261:Pulmonary Atelectasis / Q000139:chemically induced / Q000276:immunology; D013256:Steroids; D000068878:Trastuzumab; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D005938:Glucocorticoids; D013256:Steroids; D000068878:Trastuzumab