Pemphigus erythematosus associated with anti-DNA antibodies and multiple anti-ENA antibodies: a case report.
Pemphigus erythematosus (PE) is an autoimmune blistering disease combining features of pemphigus foliaceus (PF) and systemic lupus erythematosus (SLE). We report a case of PE associated with anti-double-stranded DNA (anti-dsDNA), anti-Smith (anti-Sm), anti-Ro (anti-SSA), and antiribonucleoprotein (anti-RNP) antibodies. This case required extensive immunosuppressive therapy. We treated our patient with a combination of systemic steroids, intramuscular gold injections, azathioprine, and hydroxychloroquine. The patient's response was complete remission--evaluated clinically, serologically, and immunohistochemically.
Department of Dermatology, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, New York, USA. scheinfeld@earthlink.net
Noah S
NS
Scheinfeld
Kenneth L
KL
Howe
Damian P
DP
DiCostanzo
Errol
E
Craig
Steven R
SR
Cohen
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D034961:Antigens, Nuclear / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D010392:Pemphigus / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000473:pathology
D000974:Antibodies, Antinuclear; D034961:Antigens, Nuclear; D001323:Autoantibodies