Enantio- and diastereoselective synthesis of cyclic beta-hydroxy allylsilanes via sequential aldehyde gamma-silylallylboration and ring-closing metathesis reactions.
[reaction: see text] Highly enantioenriched cyclic allylsilanes are prepared via stereoselective gamma-silylallylboration reactions of beta- or gamma-unsaturated aldehydes followed by ring-closing metathesis.
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
Jung-Nyoung
JN
Heo
Glenn C
GC
Micalizio
William R
WR
Roush
D000447:Aldehydes / Q000737:chemistry*; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D012821:Silanes / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000447:Aldehydes; D012821:Silanes