Chemically assisted dissection of tissues in laparoscopic excision of endometriotic cysts.
OBJECTIVE
To evaluate the capacity of chemical dissection of tissues using a mucolytic substance, Mesna, in improving laparoscopic excision of endometriotic cysts.


METHODS
Randomized, double-blind, controlled trial (Canadian Task Force classification I).


METHODS
University-affiliated training hospital.


METHODS
Forty-four women with symptomatic ovarian endometriotic cysts. Intervention. Laparoscopic excision of endometriotic cysts in 22 women with the aid of Mesna solution and in 22 with the aid of saline solution.


RESULTS
In comparison with saline solution, Mesna as a chemical dissector resulted in significant reductions in operating time, in difficulty encountered by the surgeon to enucleate the cysts, and in less bleeding. No differences were found in length of hospital stay, costs of surgeries, analgesic requirement, and fever. Postoperatively, patients treated with Mesna achieved more pregnancies than those treated with saline.


CONCLUSIONS
Chemical dissection of tissues with Mesna proved to be a safe and suitable support in laparoscopic surgery for ovarian endometriotic cysts.
Department of Obstetrics, Gynaecology, and Neonatology, University of Parma, Via Gramsci, 14, 43100 Parma, Italy.
Luigi
L
Benassi
Gianluca
G
Benassi
Christine Tita
CT
Kaihura
Lorenza
L
Marconi
Luisa
L
Ricci
Eugenio
E
Vadora
D000328:Adult; D003131:Combined Modality Therapy; D004210:Dissection; D004311:Double-Blind Method; D004715:Endometriosis / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D015080:Mesna / Q000627:therapeutic use*; D010048:Ovarian Cysts / Q000150:complications / Q000473:pathology / Q000601:surgery*; D010049:Ovarian Diseases / Q000150:complications / Q000473:pathology / Q000601:surgery*; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
D015080:Mesna