Different synaptic mechanisms of long-term potentiation induced by nicotine and tetanic stimulation in hippocampal CA1 region of rats.
OBJECTIVE
To investigate whether long-term potentiation (LTP) induced by nicotine and tetanic stimulation in the hippocampal CA1 region shares different mechanisms.


METHODS
Extracellular population spikes of the pyramidal cell layer in the hippocampal CA1 region were recorded in vitro.


RESULTS
LTP induced by the tetanic stimulation could be facilitated by nicotine 10 micromol/L, meanwhile, the tetanic stimulation did the same effect on LTP induced by nicotine 10 micromol/L. MK-801 10 micromol/L or NG-nitro-L-arginine methyl ester (L-NAME) 20 micromol/L blocked LTP induced by tetanic stimulation, but did not inhibit LTP induced by nicotine.


CONCLUSIONS
LTP induced by nicotine shares different synaptic mechanisms with LTP induced by tetanic stimulation.
Department of Pharmacology, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510089, China.
Jin
J
He
Chun-Yu
CY
Deng
Xiao-Nan
XN
Zhu
Jian-Ping
JP
Yu
Ru-Zhu
RZ
Chen
D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D005731:Ganglionic Stimulants / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009538:Nicotine / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013569:Synapses / Q000187:drug effects* / Q000502:physiology
D005731:Ganglionic Stimulants; D016291:Dizocilpine Maleate; D009538:Nicotine; D019331:NG-Nitroarginine Methyl Ester