Compact, broad-bandwidth fiber laser for sub-2-microm axial resolution optical coherence tomography in the 1300-nm wavelength region.
A novel, compact, user friendly fiber laser with a broad emission bandwidth (MenloSystems, lambdac = 1375 nm, deltalambda = 470 nm, Pout = 4 mW) was used to achieve unprecedented sub-2-microm axial resolution optical coherence tomography (OCT) in nontransparent biological tissue in the 1300-nm wavelength region. Fresh human skin and arterial biopsies were imaged ex vivo with approximately 1.4-microm axial and approximately 3-microm lateral resolution and 95-dB sensitivity, demonstrating the great potential for clinical OCT applications of this stable, low-cost, and turn-on-key fiber laser.
Department of Medical Physics, Christian Doppler Laboratory, University of Vienna, Waehringer Strasse 13, Vienna, Austria.
K
K
Bizheva
B
B
Povazay
B
B
Hermann
H
H
Sattmann
W
W
Drexler
M
M
Mei
R
R
Holzwarth
T
T
Hoelzenbein
V
V
Wacheck
H
H
Pehamberger
D001158:Arteries / Q000473:pathology; D001706:Biopsy / Q000379:methods; D006801:Humans; D007834:Lasers; D012867:Skin / Q000473:pathology; D014054:Tomography / Q000295:instrumentation / Q000379:methods*