Placental calcium pump: clinical-based evidence.
Placenta can be considered as a pump of calcium necessary for the normal development of the fetus. We believe that the location of this pump is in the placental basement membrane. The calcification of this membrane has been described only in cases of in utero fetal death. In this study we describe for the first time a case of placental calcification in a living fetus. The fetus of a normal 21-year-old pregnant woman showed heart abnormalities but the genetic analysis showed a normal male karyotype. The histology of the placenta demonstrated multiple intravillous linear and granular calcific incrustations The hemtoxylin/eosin stain of the sections revealed basement membrane calcific incrustations and intravillous calcium deposits. We postulate that the fetal circulation in the villi was impaired and the calcium that reached the villi from the mother was deposited at this level.
Mallory Institute of Pathology, Boston University School of Medicine, Boston, Massachusetts, USA.
John M
JM
Kasznica
Eugen B
EB
Petcu
D000015:Abnormalities, Multiple; D000025:Abortion, Eugenic; D000328:Adult; D001485:Basement Membrane / Q000378:metabolism / Q000473:pathology; D002114:Calcinosis / Q000378:metabolism / Q000473:pathology; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002824:Chorionic Villi / Q000378:metabolism / Q000473:pathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications
D000252:Calcium-Transporting ATPases; D002118:Calcium