The association between psychosocial factors and vaccine-induced cytokine production.
Existing data suggest that immune function is compromised by negative psychosocial factors. We hypothesized that high psychological well being and quality relationships would be associated with vigorous cytokine responses to vaccination. Lymphocytes from 18 individuals were studied for their ability to produce interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) with influenza or hepatitis A immunization. Psychological well being and relationship quality were measured using standardized scales. Significant positive correlations were made between psychological well being and quality relationships and IFN-gamma and IL-10 production to influenza and hepatitis A on day 28 (Pearson correlations: 0.6-0.7; P<0.05). This preliminary study represents one of the first to show positive physiological health is associated with positive psychosocial factors.
University of Wisconsin School of Pharmacy, 777 Highland Avenue, Madison, WI 53705-2222, USA. mshayney@pharmacy.wisc.edu
Mary S
MS
Hayney
Gayle Dienberg
GD
Love
Jessica M
JM
Buck
Carol D
CD
Ryff
Burton
B
Singer
Daniel
D
Muller
D001294:Attitude to Health; D016207:Cytokines / Q000097:blood* / Q000187:drug effects; D004522:Educational Status; D005260:Female; D022362:Hepatitis A Vaccines; D006801:Humans; D007252:Influenza Vaccines; D007371:Interferon-gamma / Q000096:biosynthesis / Q000097:blood; D016753:Interleukin-10 / Q000096:biosynthesis / Q000097:blood; D007398:Interpersonal Relations; D008137:Longitudinal Studies; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D011584:Psychology / Q000145:classification*; D013997:Time Factors; D014612:Vaccines / Q000276:immunology* / Q000494:pharmacology; D014922:Wisconsin
D016207:Cytokines; D022362:Hepatitis A Vaccines; D007252:Influenza Vaccines; D014612:Vaccines; D016753:Interleukin-10; D007371:Interferon-gamma