Targeting smokers at increased risk for relapse: treating women and those with a history of depression.
Some studies have shown that female smokers and smokers with a history of depression have an increased risk of relapse following smoking cessation treatment. This study examined the efficacy of bupropion sustained-release (SR) and the nicotine patch for smoking cessation in subgroups of smokers at possible risk for relapse. Data for this study were from a previously published randomized, double-blind, placebo-controlled clinical trial in which 893 smokers were randomized to four treatment conditions: placebo tablet + placebo patch, placebo tablet + 21 mg/24-hr nicotine patch, 300mg bupropion SR + placebo patch, and 300mg bupropion SR + 21 mg/24-hr nicotine patch. Study medication continued for 8 weeks after the quit day; brief individual cessation counseling was provided during weekly clinic visits. In comparison to the placebo tablet, bupropion SR approximately tripled 1-year non-smoking rates among women and previously depressed individuals. In contrast, the nicotine patch did not significantly improve cessation rates for any group. We conclude that bupropion SR is a first-line treatment for smoking that has the potential to benefit all smokers, especially women and the previously depressed.
Smith
Stevens S
SS
Center for Tobacco Research and Intervention, Department of Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53711-2027, USA. sss@ctri.medicine.wisc.edu
Jorenby
Douglas E
DE
Leischow
Scott J
SJ
Nides
Mitchell A
MA
Rennard
Stephen I
SI
Johnston
J Andrew
JA
Jamerson
Brenda
B
Fiore
Michael C
MC
Baker
Timothy B
TB
D000279:Administration, Cutaneous; D016642:Bupropion / Q000008:administration & dosage; D003863:Depression / Q000453:epidemiology / Q000523:psychology*; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage; D012008:Recurrence; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D016540:Smoking Cessation / Q000379:methods* / Q000706:statistics & numerical data; D000074606:Smoking Prevention
D018765:Dopamine Uptake Inhibitors; D016642:Bupropion; D009538:Nicotine