A novel peptide synthesis using fluorous chemistry.
Three new fluorous supports for peptide synthesis, i.e., the trialkoxybenzhydryl-type (6), the Wang-type (7) and the tert-butyl-type support (8), were prepared. A bioactive peptide TRH was easily synthesized by an Fmoc strategy using the benzhydryl-type fluorous support with fluorous chemistry.
The Noguchi Institute, 1-8-1, Kaga, Itabashi-ku, Tokyo 173-0003, Japan.
Mamoru
M
Mizuno
Kohtaro
K
Goto
Tsuyoshi
T
Miura
Daisuke
D
Hosaka
Toshiyuki
T
Inazu
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D005449:Fluorenes / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D012117:Resins, Synthetic / Q000737:chemistry / Q000145:classification; D013973:Thyrotropin-Releasing Hormone / Q000138:chemical synthesis*
D000596:Amino Acids; D005449:Fluorenes; D006845:Hydrocarbons, Fluorinated; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D012117:Resins, Synthetic; D013973:Thyrotropin-Releasing Hormone