Protein microarrays: meeting analytical challenges for clinical applications.
Protein microarrays, one emerging class of proteomic technologies, have broad applications for discovery and quantitative analysis. A rapidly expanding use of this technology is the acquisition of information about the posttranslational modifications of proteins reflecting the activity state of signal pathways and networks, and is now employed for the analysis of biopsy samples in clinical trial research.
Liotta
Lance A
LA
FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. liottal@mail.nih.gov
Espina
Virginia
V
Mehta
Arpita I
AI
Calvert
Valerie
V
Rosenblatt
Kevin
K
Geho
David
D
Munson
Peter J
PJ
Young
Lynn
L
Wulfkuhle
Julia
J
Petricoin
Emanuel F
EF
D000818:Animals; D000906:Antibodies; D001709:Biotechnology; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D040081:Protein Array Analysis / Q000379:methods*; D020543:Proteome; D012680:Sensitivity and Specificity; D015398:Signal Transduction
D000906:Antibodies; D020543:Proteome