Phase advancing human circadian rhythms with short wavelength light.
The photoreceptor(s) responsible for photoresetting of the human circadian system have not been identified. The aim of the present study was to assess the ability of short wavelength light to alter the timing of circadian rhythms. Eleven male subjects were studied in 15 4-day trials with a single 4 h light pulse administered on day 3, immediately after habitual wake time. The magnitude of the phase shifts in the melatonin acrophase and offset were similar after white (4300 microW/cm(2)) and short wavelength (28 microW/cm(2)) light exposure even though the white light pulse contained 185-fold more photons than the short wavelength light. This finding suggests short wavelength sensitivity of the photoreceptors mediating synchronization of human circadian rhythms.
Warman
Victoria L
VL
Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Surrey, GU2 7XH, Guildford, UK. v.warman@surry.ac.uk
Dijk
Derk Jan
DJ
Warman
Guy R
GR
Arendt
Josephine
J
Skene
Debra J
DJ
D000328:Adult; D001831:Body Temperature; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D008027:Light; D008297:Male; D008550:Melatonin / Q000097:blood; D010786:Photoreceptor Cells / Q000502:physiology; D012016:Reference Values; D012890:Sleep; D014785:Vision, Ocular / Q000502:physiology; D014851:Wakefulness
D008550:Melatonin