Proton MR spectroscopy of gliomatosis cerebri: case report of elevated myoinositol with normal choline levels.
A 69-year-old woman presented with clinical and imaging findings suspicious for gliomatosis cerebri, later confirmed by biopsy (moderately cellular, infiltrating glioma). Single voxel proton MR spectroscopy (TE 20 and TE 135) and spectroscopic imaging (TE 135) performed at admission showed normal choline, decreased N-acetyl, and elevated myo-inositol levels relative to creatine. The primary conclusion is that in suspected cases of gliomatosis cerebri, myo-inositol/creatine and myo-inositol/N-acetyl should be determined because they may provide evidence of tumor, even though choline/creatine is normal. A corollary to this conclusion is that choline/creatine may be misleading if used to demarcate infiltrating glioma from edema.
Department of Radiology, University of Miami School of Medicine, FL 33135, USA.
Efrat
E
Saraf-Lavi
Brian C
BC
Bowen
Pradip M
PM
Pattany
Evelyn M L
EM
Sklar
James B
JB
Murdoch
Carol K
CK
Petito
D000368:Aged; D001932:Brain Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D002794:Choline / Q000032:analysis*; D003401:Creatine / Q000032:analysis; D005260:Female; D006801:Humans; D007294:Inositol / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D018302:Neoplasms, Neuroepithelial / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology
D007294:Inositol; D003401:Creatine; D002794:Choline