Antioxidant evaluations of novel N-H and N-substituted indole esters.
The anti-lipid peroxidation (LP) activity and anti-superoxide formation (SOD) of new N-H and N-substituted indole derivatives were evaluated to determine their antioxidant activity. The results showed that compounds 1, 2, 5, 9 and 12 demonstrate considerable inhibition of lipid peroxidation of mouse liver homogenate. On the other hand, compounds 5 and 12 showed anti-superoxide formation activity at a concentration of 10(-4) M. Consequently, it can be concluded that these compounds exhibit important activity compared with reference compound alpha-tocopherol (vitamin E).
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ankara, Turkey. olgen@pharmacy.ankara.edu.tr
Süreyya
S
Olgen
Tülay
T
Coban
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045304:Cytochromes c / Q000737:chemistry; D004952:Esters; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000037:antagonists & inhibitors; D024502:alpha-Tocopherol / Q000737:chemistry
D000975:Antioxidants; D004952:Esters; D007211:Indoles; D013481:Superoxides; D045304:Cytochromes c; D024502:alpha-Tocopherol