Variant Salmonella genomic island 1 antibiotic resistance gene cluster in Salmonella enterica serovar Albany.
Salmonella genomic island 1 (SGI1) contains an antibiotic resistance gene cluster and has been previously identified in multidrug-resistant Salmonella enterica serovars Typhimurium DT104, Agona, and Paratyphi B. We identified a variant SGI1 antibiotic-resistance gene cluster in a multidrug-resistant strain of S. enterica serovar Albany isolated from food fish from Thailand and imported to France. In this strain, the streptomycin resistance aadA2 gene cassette in one of the SGI1 integrons was replaced by a dfrA1 gene cassette, conferring resistance to trimethoprim and an open reading frame of unknown function. Thus, this serovar Albany strain represents the fourth S. enterica serovar in which SGI1 has been identified and the first SGI1 example where gene cassette replacement took place in one of its integron structures. The antibiotic resistance gene cluster of serovar Albany strain 7205.00 constitutes a new SGI1 variant; we propose a name of SGI1-F.
Unité BioAgresseurs, Santé, Environnement, Institut National de la Recherche Agronomique, 37380 Nouzilly, France.
Benoît
B
Doublet
Renaud
R
Lailler
Danièle
D
Meunier
Anne
A
Brisabois
David
D
Boyd
Michael R
MR
Mulvey
Elisabeth
E
Chaslus-Dancla
Axel
A
Cloeckaert
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D022761:Gene Transfer, Horizontal; D005798:Genes, Bacterial; D014644:Genetic Variation; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D010641:Phenotype; D019779:Salmonella enterica / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D016415:Sequence Alignment; D020079:Terminal Repeat Sequences / Q000235:genetics
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial