Hypertriglyceridemic waist as a screening tool for CVD risk in indigenous Australian women.
Research has demonstrated that the simultaneous determination of waist circumference and fasting plasma triglyceride (TG) concentrations can identify men characterized by a metabolic triad of unconventional risk variables: increased levels of fasting insulin, apolipoprotein (apo) B, and a predominance of small, dense, low density lipoprotein (LDL) particles. The aim of this study was to assess the efficacy of using "hypertriglyceridemic waist" to identify individuals at high risk of CVD in a sample of indigenous Australian women, for whom 2 of the 3 non-traditional risk factors were measured (apo B and insulin). Subjects (N=80) were divided into subgroups on the basis of waist girth and TG levels. The TG/HDL ratio increased in women with both elevated waist (above 95 cm) and TG levels (above 2.0 mmol/L), who were also characterized by lower HDL and elevated LDL concentrations. Although there was no trend toward an increase in apo B with increasing waist girth and TG levels, apo B concentration was highest among subgroups with elevated waist and TG levels. Fasting insulin levels were higher with increasing waist girth, but not with increasing TG levels. Utilizing hypertriglyceridemic waist as a marker of high plasma insulin and apo B can be an important factor in assessing cardiovascular risk in indigenous Australian women, despite an unexpected apo B distribution.
School of Biomedical Sciences, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW.
Yumiko
Y
Hiura
Fay
F
Acklin
Jennifer
J
Newman
Kate
K
Steinbeck
Ian D
ID
Caterson
Deepika
D
Mahajan
Kaye
K
Brock
Margaret A
MA
Bermingham
D000886:Anthropometry; D001055:Apolipoproteins B / Q000097:blood; D001315:Australia / Q000453:epidemiology / Q000208:ethnology; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000453:epidemiology*; D007328:Insulin / Q000097:blood; D008403:Mass Screening; D012307:Risk Factors; D016387:Women's Health
D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin