Synthesis and properties of star-shaped polylactide attached to poly(amidoamine) dendrimer.
Star-shaped polylactide was synthesized by bulk polymerization of lactide with poly(amidoamine) (PAMAM) dendrimer as initiator, which was marked as PAMAM-g-PLA for simplicity. The nonlinear architecture of PAMAM-g-PLA was confirmed by gel permeation chromatograph, nuclear magnetic resonance, and differential scanning calorimetry analysis. Unlike the linear polylactide (PLA) with similar molecular weight, PAMAM-g-PLA had a higher hydrophilicity and a faster degradation rate because of shortened polymer chains and increased polar terminal endgroups due to its branch structure. The highly branched structure significantly accelerated the release of water-soluble bovine serum albumin from PAMAM-g-PLA microspheres, whereas the linear PLA with similar molecular weight exhibited an initial time lag release. This star polymer may have potential applications for hydrophilic drug delivery in tissue engineering, including growth factor and antibodies to induce tissue regeneration, by adjusting the chain lengths of PLA branches.
Cai
Qing
Q
SKLPPC, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
Zhao
Youliang
Y
Bei
Jianzhong
J
Xi
Fu
F
Wang
Shenguo
S
D000818:Animals; D002417:Cattle; D050091:Dendrimers; D011073:Polyamines / Q000032:analysis* / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011091:Polyesters / Q000032:analysis* / Q000138:chemical synthesis* / Q000493:pharmacokinetics
D050091:Dendrimers; C104700:PAMAM Starburst; D011073:Polyamines; D011091:Polyesters; C033616:poly(lactide)