Training-induced adaptation of oxidative phosphorylation in skeletal muscles.
Muscle training/conditioning improves the adaptation of oxidative phosphorylation in skeletal muscles to physical exercise. However, the mechanisms underlying this adaptation are still not understood fully. By quantitative analysis of the existing experimental results, we show that training-induced acceleration of oxygen-uptake kinetics at the onset of exercise and improvement of ATP/ADP stability due to physical training are mainly caused by an increase in the amount of mitochondrial proteins and by an intensification of the parallel activation of ATP usage and ATP supply (increase in direct stimulation of oxidative phosphorylation complexes accompanying stimulation of ATP consumption) during exercise.
Institute of Molecular Biology and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387 Kraków, Poland. benio@mol.uj.edu.pl
Bernard
B
Korzeniewski
Jerzy A
JA
Zoladz
D000222:Adaptation, Physiological / Q000502:physiology*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D003198:Computer Simulation; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000502:physiology*; D010085:Oxidative Phosphorylation; D010807:Physical Endurance
D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate