Chronic cholestasis associated with Turner's syndrome: 12 years of clinical and histopathological follow-up.
Clinically significant liver disease is probably a rare condition in Turner's syndrome and only a few cases of severe liver disease have been described. The natural history of patients with Turner's syndrome and elevated cholestatic liver enzymes is unclear. We report a case with a long history of intrahepatic cholestasis and without clinical or histopathological progression in 12 years of follow-up. Like some other reports our case suggests, also histologically, that the liver disease in these patients runs a benign course.
Wardi
Joram
J
Department of Gastroenterology, The Edith Wolfson Medical Center, Holon, Israel. wardi@wolfson.health.gov.il
Knobel
Boleslaw
B
Shahmurov
Mark
M
Melamud
Enrique
E
Avni
Yona
Y
Shirin
Haim
H
D002780:Cholestasis, Intrahepatic / Q000209:etiology* / Q000473:pathology; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008111:Liver Function Tests; D008875:Middle Aged; D014424:Turner Syndrome / Q000150:complications*