Substituted bridged phenyl piperidines: orally active growth hormone secretagogues.
A new series of growth hormone secretagogues have been discovered. The best compound, 26j, shows excellent ability to release growth hormone both in vitro and in vivo. The synthesis and biological activity of these compounds are discussed.
Lu
Zhijian
Z
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. zhijian_lu@merck.com
Tata
James R
JR
Cheng
Kang
K
Wei
Liente
L
Chan
Wanda W-S
WW
Butler
Bridget
B
Schleim
Klaus D
KD
Jacks
Thomas M
TM
Hickey
Gerard
G
Patchett
Arthur A
AA
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004285:Dogs; D013006:Growth Hormone / Q000032:analysis / Q000378:metabolism*; D010880:Piperidines / Q000138:chemical synthesis* / Q000493:pharmacokinetics* / Q000494:pharmacology; D010902:Pituitary Gland / Q000166:cytology; D051381:Rats; D013329:Structure-Activity Relationship
D010880:Piperidines; D013006:Growth Hormone