Management of the elderly aortic stenosis patient with low gradient and low ejection fraction.
The incidence of aortic stenosis increases with age and thus it occurs frequently in elderly patients. Once severe obstruction has developed, death occurs within 3 years unless the aortic valve is replaced. The results of aortic valve surgery, even in octogenarians, are usually excellent in the absence of comorbidity. The exception to this rule is for the aortic stenosis patient who has low ejection fraction, a low cardiac output and a transvalvular gradient of <30 mm Hg. Such patients have far advanced left ventricular dysfunction and increased operative mortality. However, even these patients may benefit from surgery if they have truly severe aortic stenosis. Because valve area is unreliable at low cardiac outputs, output should be increased pharmacologically in such patients and the valve area recalculated. If the transvalvular gradient increases with output, severe aortic stenosis is present and valve replacement may be beneficial. However, if output increases but gradient does not, only mild stenosis is present and surgery is unlikely to prolong life.
Department of Medicine, Baylor College of Medicine and Houston Veterans Affairs Medical Center, Houston, TX 77030, USA. BlaseAnthony.Carabello@med.va.gov
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D000368:Aged; D001024:Aortic Valve Stenosis / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D002303:Cardiac Output, Low / Q000503:physiopathology; D015897:Comorbidity; D006350:Heart Valve Prosthesis; D006801:Humans; D013318:Stroke Volume / Q000502:physiology*; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology