Analysis of the mitochondrial genome in sudden infant death syndrome.
OBJECTIVE
To investigate the mitochondrial genome and its association with sudden infant death syndrome (SIDS).


METHODS
Twenty SIDS infants were screened for previously reported mitochondrial DNA mutations using direct sequencing. The whole mitochondrial genome was also sequenced for six of the infants.


RESULTS
Three substitutions, A11467G, A12308G and G12372A, comprising a haplogroup were present in four infants diagnosed as pure SIDS. This haplogroup was also common in a control group.


CONCLUSIONS
No specific mutation or polymorphism was found in association with SIDS.
Divne
A M
AM
Department of Genetics and Pathology, Uppsala University, Sweden.
Råsten-Almqvist
P
P
Rajs
J
J
Gyllensten
U
U
Allen
Marie
M
D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015894:Genome, Human; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics; D013398:Sudden Infant Death / Q000209:etiology / Q000235:genetics*
D004272:DNA, Mitochondrial