[Study on mitochondrial membrane mechanism of rat heart injury induced by constrainting stress].
OBJECTIVE
To investigate the effect of constrainting stress on biological characters and function of mitochondrial membrane in rat heart and to explore the possible mitochondrial membrane mechanism underlying stress-induced heart injury.


METHODS
Stress animal model was established. After constrained for different times, all rats were killed and several indexes were examined.


RESULTS
Constrainting stress can induce mitochondrial permeability transition, decrease of mitochondrial membrane fluidity, increase of the production of membrane lipid peroxidation and injury of mitochondrial respiratory function which is in time-dependent manner.


CONCLUSIONS
Mitochondrial membrane impairment and its effects are the important mechanism of stress-induced heart injury.
Institute of Hygiene & Environmental Medicine, Tianjin, China.
Hui-rong
HR
Ren
Ling-jia
LJ
Qian
Jing-bo
JB
Gong
Xin-xing
XX
Wang
Chong-yu
CY
Ren
D000818:Animals; D006321:Heart / Q000503:physiopathology*; D007425:Intracellular Membranes / Q000473:pathology* / Q000502:physiology / Q000648:ultrastructure; D015227:Lipid Peroxidation / Q000502:physiology; D008560:Membrane Fluidity / Q000502:physiology; D008928:Mitochondria / Q000473:pathology* / Q000502:physiology / Q000648:ultrastructure; D009206:Myocardium / Q000473:pathology / Q000648:ultrastructure; D010539:Permeability; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000503:physiopathology*