Pleomorph poorly differentiated endocrine carcinoma of the rectum.
We present a case of poorly differentiated endocrine carcinoma (PDEC) of the rectum identified immunohistochemically and characterized by a high degree of cellular pleomorphism, including bizarre giant cells. This case indicates that gastrointestinal PDECs are not restricted to small cell carcinomas. Among the multiple genes investigated, loss of heterozygosity (LOH) of the p53 locus without p53 immohistochemical accumulation, overexpression of c-kit and absent expression of p16 were seen.
Department of Pathology and Laboratory Medicine, Section of Anatomic Pathology, University of Parma, 43100, Parma, Italy.
Pellegrino
P
Crafa
Massimo
M
Milione
Cinzia
C
Azzoni
Francesco Paolo
FP
Pilato
Silvia
S
Pizzi
Cesare
C
Bordi
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry / Q000235:genetics / Q000556:secondary*; D004273:DNA, Neoplasm / Q000032:analysis; D017809:Fatal Outcome; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D019656:Loss of Heterozygosity; D008297:Male; D018895:Microsatellite Repeats; D010166:Palliative Care; D012004:Rectal Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm