Hemsleyatine, a novel C19-diterpenoid alkaloid with 8-amino group from Aconitum hemsleyanum.
The new compound hemsleyatine (1) was isolated along with four known C(19)-diterpenoid alkaloids: indaconitine (4), yunaconitine (5), chasmanine (6), and talatisamine (7) from the roots of Aconitum hemsleyanum PRITZ. Structures were established by spectral analysis, including tow dimeusional (2D) NMR spectroscopy and a chemical method. Hemsleyatine (1) is the first C(19)-diterpenoid alkaloid bearing the 8-amino group. In addition, the assignments of some (13)C signals for pseudaconine (3) were revised by comparison with those of hemsleyatine (1).
Department of Bioengineering, Southwest Jiaotong University, Chengdu, P.R. China.
Xian-Li
XL
Zhou
Qiao-Hong
QH
Chen
Dong-Lin
DL
Chen
Feng-Peng
FP
Wang
D000107:Acetylation; D031841:Aconitum / Q000737:chemistry*; D002681:China; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D018517:Plant Roots / Q000737:chemistry
D004224:Diterpenes; D007202:Indicators and Reagents; C479944:hemsleyatine