Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of dextran and dextrin derivatives.
Application of matrix-assisted laser desorption/ionization (MALDI) to the analysis of dextran and dextrin derivatives, specifically glucose saccharides, by time-of-flight (TOF) mass spectrometry has been reported. MALDI-TOF analysis was carried out on alpha-, beta- and gamma-cyclodextrin, two O-methylated-beta-cyclodextrins of differing degrees of substitution (DS) and dextrans (a linear glucose saccharide), as pure and doped solutions and as mixtures of two or more of these. Doping was carried out with trace amounts of inorganic salts. The purpose of the analysis of the cyclodextrins was to determine whether they would form inclusion complexes with the various cations added, or whether less specific cation addition/exchange was occurring either prior to desorption or in the gas phase.
Institute for Mass Spectrometry, University of Warwick, Coventry CV4 7AL, UK.
Sajid
S
Bashir
Peter J
PJ
Derrick
Peter
P
Critchley
Paul J
PJ
Gates
James
J
Staunton
D003505:Cyclodextrins / Q000032:analysis / Q000737:chemistry; D003911:Dextrans / Q000032:analysis* / Q000737:chemistry*; D003912:Dextrins / Q000032:analysis* / Q000737:chemistry*; D008970:Molecular Weight; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D003505:Cyclodextrins; D003911:Dextrans; D003912:Dextrins