Effect of a calcium carbonate-based dentifrice on enamel demineralization in situ.
Since the effect of calcium carbonate (CaCO(3)) based dentifrice on enamel demineralization is not clearly established, it was evaluated using the IEDT model described by Zero's group in 1992. This study had a crossover design and 10 volunteers were submitted to 3 treatment groups: a negative control, brushing without dentifrice; an active control, brushing with silica-based dentifrice (SiO(2)/MFP group), and the experimental group, brushing with CaCO(3)-based dentifrice (CaCO(3)/MFP). Both dentifrices contained 1,500 microgram F/g (w/w) as sodium monofluorophosphate (MFP). Enamel surface microhardness was determined in the dental blocks and the percentage change in relation to baseline was calculated. Fluoride uptake in enamel and its concentration in 'test plaque' were determined. The results showed that the dentifrice containing CaCO(3)/MFP was more effective than SiO(2)/MFP in reducing enamel demineralization (p < 0.05). A higher concentration of fluoride ion was found in 'test plaque' treated with CaCO(3)/MFP than in the negative control (p < 0.05). The results suggest that CaCO(3) abrasive may enhance the effect of fluoride present in dentifrice on dental caries control.
Cury
J A
JA
Faculty of Dentistry of Piracicaba, State University of Campinas, Piracicaba, SP, Brazil. jcury@fop.unicamp.br
Francisco
S B
SB
Simões
G S
GS
Del Bel Cury
A A
AA
Tabchoury
C P M
CP
D000328:Adult; D000818:Animals; D002119:Calcium Carbonate / Q000494:pharmacology*; D002327:Cariostatic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002417:Cattle; D018592:Cross-Over Studies; D003743:Dental Enamel / Q000187:drug effects / Q000378:metabolism; D003773:Dental Plaque / Q000378:metabolism; D003802:Dentifrices / Q000737:chemistry; D004338:Drug Combinations; D004357:Drug Synergism; D005459:Fluorides / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006244:Hardness / Q000187:drug effects; D006801:Humans; D010710:Phosphates / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012822:Silicon Dioxide / Q000494:pharmacology; D017001:Tooth Demineralization / Q000517:prevention & control*
D002327:Cariostatic Agents; D003802:Dentifrices; D004338:Drug Combinations; D010710:Phosphates; C012980:fluorophosphate; D012822:Silicon Dioxide; D002119:Calcium Carbonate; D005459:Fluorides