Neurotrophins in myelination: a new role for a puzzling receptor.
Binding of neurotrophins to p75(NTR) was recently identified as a positive signal for myelination by Schwann cells. This new finding adds yet another distinct biological role to the growing list of functions of p75(NTR) in the nervous system and identifies a novel target for promoting remyelination in peripheral neuropathies or post-nerve-injury.
Department of Neuroscience, College of Medicine, McKnight Brain Institute of the University of Florida, Box 100244, Gainesville, FL 32610, USA. notterp@ufbi.ufl.edu
Lucia
L
Notterpek
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002478:Cells, Cultured; D003711:Demyelinating Diseases / Q000378:metabolism / Q000503:physiopathology; D005544:Forecasting; D006801:Humans; D009414:Nerve Growth Factors / Q000145:classification / Q000378:metabolism*; D010523:Peripheral Nervous System Diseases / Q000378:metabolism / Q000503:physiopathology; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*; D012583:Schwann Cells / Q000378:metabolism
D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor