Epigenetics in carcinogenesis and cancer prevention.
Carcinogenesis is a stepwise process of accumulation of genetic and epigenetic abnormalities that can lead to cellular dysfunction. It has become clear that epigenetic changes are equally important for this multistep process to produce its results. This article describes the different roles that epigenetic modulation may play during carcinogenesis and how an early detection and chemopreventive intervention strategy that takes both sides of the equation into account would be advantageous.
Jones
Peter A
PA
Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089-9181, USA. jones_p@ccnt.hsc.usc.edu
D002471:Cell Transformation, Neoplastic; D018899:CpG Islands / Q000235:genetics; D019175:DNA Methylation; D004261:DNA Replication; D020868:Gene Silencing; D016147:Genes, Tumor Suppressor; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control; D014158:Transcription, Genetic