Effect of dai-kenchu-to on obstructive bowel disease in children.
The aim of this study was to evaluate the effects of a traditional Chinese herbal medicine, dai-kenchu-to (DKT), on obstructive bowel diseases in children. We have treated 46 pediatric patients with various obstructive bowel diseases with DKT: six patients with postoperative ileus, 12 with large abdominal surgery (including three neonates), one with ano-rectal anomaly, three with Hirschsprung's disease, two with functional bowel obstructions, one with SMA syndrome, and 21 patients with chronic constipation. DKT (0.1-0.15 g/kg) was mixed with 5-10 ml of warm water, and was given orally two to three times a day. DKT was effective for 39 patients (85%) and their clinical symptoms improved. DKT was ineffective in seven patients: two with postoperative ileus, two with Hirschsprung's disease, and three with chronic constipation. DKT had mild but significant effects for various obstructive bowel diseases in children, while no side effects were encountered. Our current strategy for pediatric patients with obstructive bowel disease is to use DKT first and then test its efficacy. If DKT is effective, the regimen is continued. However, in cases where DKT is not effective, we will consider laparotomy or will further investigate the illness.
Ohya
Toshiki
T
Department of Surgery, Tokyo Medical and Dental University, School of Medicine 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. ohya.srg1@tmd.ac.jp
Usui
Yoshiko
Y
Arii
Shigeki
S
Iwai
Takehisa
T
Susumu
Tsunoda
T
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003248:Constipation / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006627:Hirschsprung Disease / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007415:Intestinal Obstruction / Q000188:drug therapy*; D008297:Male; D009134:Muscular Atrophy, Spinal / Q000188:drug therapy; D005894:Panax; D004364:Pharmaceutical Preparations; D010936:Plant Extracts / Q000627:therapeutic use*; D016896:Treatment Outcome; D032106:Zanthoxylum; D030521:Zingiberaceae
D004364:Pharmaceutical Preparations; D010936:Plant Extracts; C121414:dai-kenchu-to