Uncovering the mechanisms of deep brain stimulation for Parkinson's disease through functional imaging, neural recording, and neural modeling.
High-frequency deep brain stimulation (DBS) of the thalamus or basal ganglia represents an effective clinical technique for the treatment of several medically refractory movement disorders, including Parkinson's disease. However, understanding of the mechanisms of action of DBS remains elusive. The goal of this review is to address our understanding of the effects of high-frequency stimulation within the central nervous system based on results from functional imaging, neural recording, and neural modeling experiments. Using these results, we address the main hypotheses on the mechanisms of action of DBS and conclude that stimulation-induced desynchronization of network oscillations represents the hypothesis that best explains the presently available data.
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Cameron C
CC
McIntyre
Nitish V
NV
Thakor
D001479:Basal Ganglia / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D004599:Electric Stimulation Therapy / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008959:Models, Neurological; D009415:Nerve Net / Q000503:physiopathology; D009434:Neural Pathways / Q000503:physiopathology; D009474:Neurons; D010300:Parkinson Disease / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D019736:Prostheses and Implants; D013788:Thalamus / Q000503:physiopathology*; D014055:Tomography, Emission-Computed / Q000379:methods