[Non-steroidal anti-inflammatory agents].
Non steroidal anti-inflammatory drugs have the highest rate of prescription in the world due to their efficacy in counteracting inflammation, pain, fever and blood clot (with low-dose aspirin). This therapeutic class has been recently widen by a new family of NSAID, namely COX-2 selective inhibitors or coxibs. A 50%-reduction in the rate of gastric ulcers and bleeding has been achieved with coxibs. However, some questions remain unanswered yet, such as the cardiovascular issue with coxibs. Although the tolerability of NSAIDs is generally good, some well-established good clinical practices avoid the rare unexpected events which could sparsely occurred.
Berenbaum
Francis
F
Service de rhumatologie Hôpital Saint-Antoine 75571 Paris. francis.berenbaum@sat.ap-hop-paris.fr
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D051546:Cyclooxygenase 2; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D008565:Membrane Proteins; D010146:Pain / Q000188:drug therapy*; D011451:Prostaglandin-Endoperoxide Synthases; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000517:prevention & control*; D013927:Thrombosis / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004791:Enzyme Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases