Frequency of amantadine-resistant influenza A viruses during two seasons featuring cocirculation of H1N1 and H3N2.
In two influenza seasons during which H1N1 and H3N2 cocirculated, resistance was more frequent in H3N2 strains than in H1N1 strains after amantadine treatment. Predominant amino acid substitutions in M2 protein occurred at position 31 (serine to asparagine) in H3N2 strains and at position 27 (valine to alanine) in H1N1 strains.
Saito
Reiko
R
Department of Public Health, Graduate School of Medical and Dental Sciences, Niigata City, Niigata Prefecture 951-8510, Japan. jasmine@med.niigata-u.ac.jp
Sakai
Takatsugu
T
Sato
Isamu
I
Sano
Yasuko
Y
Oshitani
Hitoshi
H
Sato
Mizuho
M
Suzuki
Hiroshi
H
D000547:Amantadine / Q000494:pharmacology*; D019943:Amino Acid Substitution; D000998:Antiviral Agents / Q000494:pharmacology*; D002675:Child, Preschool; D024882:Drug Resistance, Viral / Q000235:genetics; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology*; D007564:Japan; D012621:Seasons; D014763:Viral Matrix Proteins / Q000235:genetics; D000086082:Viroporin Proteins
D000547:Amantadine; D000998:Antiviral Agents; D014763:Viral Matrix Proteins; C031540:M-protein, influenza virus; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins