Treatment of recurrent nodular goiters with percutaneous ethanol injection: a clinical study of twelve patients.
Twelve patients who had previously undergone thyroid surgery received percutaneous ethanol injection (PEI) treatment because of recurrent nodular goiter (3 with a toxic [TN], 2 with a nontoxic cystic [NCN], and 7 with a nontoxic solid nodule [NSN]). Two of the 12 had recurrent nerve palsy contralateral to the nodule. Each patient received a mean total dose of 0.88 mL of ethanol per milliliter of nodular volume. Ethanol was injected in a mean of 3.5 sessions for solid and 3 sessions for NCN. In most cases, a slight to moderate burning pain was experienced during and for 12-48 hours after PEI treatment, and one patient experienced temporary hoarseness. One patient with TN and 2 patients with NSN became hypothyroid, 7 patients with nontoxic nodules remained euthyroid, 1 with TN became euthyroid, and a previously hyperthyroid patient with TN became subclinically hyperthyroid 1-year posttherapy. The nodule shrank by more than 50% of the pretreatment volume in all patients (8.6 +/- 2.6 vs. 2.9 +/- 1.2 mL in TN, and 12.3 +/- 4.9 vs. 4.16 +/- 2.54 mL in nontoxic nodules, pretreatment vs. 1 year posttreatment volume, respectively). With regard to the increased risk of reoperation, PEI treatment can be proposed for patients with recurrent nodular goiter requiring surgery.
Solymosi
Tamas
T
Thyroid Outpatient Departments of Bugat Hospital (Gyöngyös), Erzsebet Hospital (Jaszbereny), St Lazar Hospital (Salgotarjan) and Matra State Hospital (Kekestetö), Hungary. mosolyis@axelero.hu
Gál
Istvan
I
D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D000431:Ethanol / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006044:Goiter, Nodular / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D013963:Thyroid Hormones / Q000097:blood; D016606:Thyroid Nodule / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome
D013963:Thyroid Hormones; D000431:Ethanol