Neonatal acute renal failure secondary to maternal exposure to telmisartan, angiotensin II receptor antagonist.
Fetal and neonatal toxic effects of angiotensin II receptor antagonists have been described in animals and humans. Five cases of fetal or neonatal deaths have been reported following maternal use of sartans for hypertension. We report a case of neonatal transient renal failure following telmisartan therapy during pregnancy. This class of antihypertensive drugs should be avoided during pregnancy and breastfeeding.
Department of Pediatrics, American Memorial Hospital, Reims, France.
Christine
C
Pietrement
Lilia
L
Malot
Brigitte
B
Santerne
Bernard
B
Roussel
Jacques
J
Motte
Patrice
P
Morville
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000151:congenital*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D001562:Benzimidazoles / Q000009:adverse effects*; D001565:Benzoates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007231:Infant, Newborn; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D000077333:Telmisartan
D000806:Angiotensin-Converting Enzyme Inhibitors; D001562:Benzimidazoles; D001565:Benzoates; D000077333:Telmisartan