Analyzing randomized dose finding studies with a primary and a secondary endpoint.
The identification of the minimum effective dose for both the primary and secondary endpoint under a priori importance ordering assumption is described. Stepwise testing procedures, which conditionally test each elementary hypotheses at level alpha, but control the experimentwise Type I error rate, can be used.
Hothorn
Ludwig A
LA
Bioinformatics Unit, University of Hannover, Hannover, Germany. hothorn@bioinf.uni-hannover.de
Wassmer
Gernot
G
D004305:Dose-Response Relationship, Drug; D023381:Endpoint Determination / Q000379:methods / Q000706:statistics & numerical data*; D016032:Randomized Controlled Trials as Topic / Q000379:methods / Q000706:statistics & numerical data*