[Utility of BNP measurement in the emergency room in patients with suspected unstable angina with a normal ECG].
Unstable angina is a serious condition, difficult to diagnose in the emergency room. Clinical, electrocardiographic and biological signs (increased troponine) are not sensitive. The authors set out to assess whether measuring B natiuretic peptide in the emergency room was more sensitive for identifying symptomatic coronary lesions. One hundred and twenty patients admitted to the emergency room for chest pain compatible with the diagnosis of unstable angina and a normal ECG were included in this prospective study. All patients underwent coronary angiography during their hospital admission. The sensitivities of troponine at a threshold of 0.4 ng/ml and of brain natiuretic peptide (BNP) at a threshold of 10 pg/ml in this population were 66% and 92% respectively. The use of troponine and BNP together provided better results than troponine and BNP alone for the identification of patients with chest pain with significant coronary lesions.
Funck
F
F
Service de cardiologie, centre hospitaller de Pontoise, 6, av. de l'lle-de-France, 95300 Pontoise.
Jourdain
P
P
Guillard
N
N
Fulla
Y
Y
Sadeg
N
N
Bellorini
M
M
Loiret
J
J
Abi Aad
J
J
Deschamps
P
P
Duboc
D
D
D000789:Angina, Unstable / Q000097:blood* / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D002637:Chest Pain / Q000175:diagnosis; D017023:Coronary Angiography; D004562:Electrocardiography; D004636:Emergency Service, Hospital; D005602:France; D006801:Humans; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D019210:Troponin I / Q000097:blood*
D015415:Biomarkers; D019210:Troponin I; D020097:Natriuretic Peptide, Brain