Synthesis and biological activities of 2-functionalized purine nucleosides.
Novel purine nucleosides functionalized at the 2-position have been prepared using new applications of synthetic methodology. The target molecules were designed as potential inhibitors (as their monophosphates) of the enzyme, inosine monophosphate dehydrogenase (IMPDH), and representative inhibition data are presented. Antiviral data of the compounds are discussed.
Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, USA. vnair@rx.uga.edu
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D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002384:Catalysis; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors*; D008956:Models, Chemical; D010766:Phosphorylation; D011684:Purine Nucleosides / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D011684:Purine Nucleosides; D007168:IMP Dehydrogenase