Corruption of host seven-transmembrane proteins by pathogenic microbes: a common theme in animals and plants?
Human diseases like AIDS, malaria, and pneumonia are caused by pathogens that corrupt host chemokine G-protein coupled receptors for molecular docking. Comparatively, little is known about plant host factors that are required for pathogenesis and that may serve as receptors for the entry of pathogenic microbes. Here, we review potential analogies between human chemokine receptors and the plant seven-transmembrane MLO protein, a candidate serving a dual role as docking molecule and defence modulator for the phytopathogenic powdery mildew fungus.
Panstruga
Ralph
R
Department of Plant-Microbe Interactions, Max-Planck-Institut für Züchtungsforschung, Carl-von-Linné-Weg 10, 50829 Cologne, Germany. panstrug@mpiz-koeln.mpg.de
Schulze-Lefert
Paul
P
D000818:Animals; D005658:Fungi / Q000472:pathogenicity*; D001467:Hordeum / Q000382:microbiology*; D006801:Humans; D007113:Immunity, Innate; D010935:Plant Diseases / Q000382:microbiology; D010940:Plant Proteins / Q000737:chemistry* / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism; D019707:Receptors, Chemokine / Q000737:chemistry* / Q000378:metabolism
C104922:MLO protein, Hordeum vulgare; D010940:Plant Proteins; D011956:Receptors, Cell Surface; D019707:Receptors, Chemokine