Transient restless legs-like syndrome as a complication of opiate withrawal.
In most cases, restless legs syndrome (RLS) is an idiopathic disorder affecting patients of middle and older age. Usually, the intensity of symptoms is constant or progressive. Here, we describe two opiate addicts developing RLS during opiate withdrawal. Their RLS disappeared along with the remission of withdrawal symptoms. Both cases responded well to a treatment with Madopar (L-dopa plus benserazid). This observation encouraged us to perform a retrospective analysis of all cases of opiate addicts detoxified in our unit during a 5-month period. This analysis revealed 15 out of 120 patients who had described the symptoms of transient RLS emerging during opiate detoxification treatment. Transient RLS during opiate detoxification merits further interst in order to improve the treatment of sleep disturbances during detoxification and as a model of interaction of the dopaminergic and endorphine system in motor activity.
Department of Psychiatry and Psychotherapy, University Hospital, Essen, Germany. norbert.scherbaum@uni-essen.de
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Scherbaum
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Stüper
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Bonnet
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Gastpar
D000328:Adult; D001545:Benserazide / Q000627:therapeutic use*; D015259:Dopamine Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D009294:Narcotics / Q000009:adverse effects*; D012148:Restless Legs Syndrome / Q000188:drug therapy* / Q000209:etiology*; D013375:Substance Withdrawal Syndrome / Q000150:complications* / Q000209:etiology*; D013997:Time Factors
D015259:Dopamine Agents; D004338:Drug Combinations; D009294:Narcotics; C005177:benserazide, levodopa drug combination; D007980:Levodopa; D001545:Benserazide