[Studies on the zinc bioavailability using stable isotope techniques].
Zinc is one of essential trace elements in humans. Zinc homeostasis is mainly regulated by the changes of intestinal absorption efficiency and endogenous excretion, namely the regulation of bioavailability. Studies on zinc bioavailability play an important role on a thorough understanding of zinc metabolism and reliable assessment on population zinc status. Stable isotopes are valuable tools for research on mineral bioavailability and metabolism. Zinc stable isotopes can be used for all population as tracers with no exposure to radiation. Since 1980s' many different stable isotope methods have been applied to the zinc metabolism research. However, limitations to these approaches and methodological problems remain to be resolved. In addition, the introduction and development of new analytical instruments not only make it possible to use zinc stable isotope, also greatly diminish the difficulty and cost on it. The paper is mainly focused on the zinc bioavailability and present a review of its development history, main research methods and analytical skills.
Wang
Yan
Y
Institute of Nutrition and Food Safety, Chinese Center For Disease Control and Prevention, Beijing 100050, China.
Piao
Jianhua
J
D001682:Biological Availability; D006801:Humans; D007408:Intestinal Absorption; D015032:Zinc / Q000493:pharmacokinetics*; D015033:Zinc Isotopes
D015033:Zinc Isotopes; D015032:Zinc