Trypsin inhibitory effect of wedelolactone and demethylwedelolactone.
Wedelolactone (WL) and demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro). Both compounds showed potent activity. IC(50) values of WL and DWL were found to be 2.9 and 3.0 microg/mL respectively.
Bioassay Unit, R&D Centre, Natural Remedies Pvt Ltd, 5B, Veerasandra Indl Area, Hosur Road, Bangalore 561 229, India.
Samiulla D
SD
Syed
Mundkinajeddu
M
Deepak
Shivanna
S
Yogisha
Arun P
AP
Chandrashekar
Keerthi A
KA
Muddarachappa
Prashanth
P
D'Souza
Amit
A
Agarwal
B V
BV
Venkataraman
D000818:Animals; D002645:Chickens; D003374:Coumarins / Q000494:pharmacology*; D036601:Eclipta; D006801:Humans; D020128:Inhibitory Concentration 50; D010063:Ovum / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology*; D014357:Trypsin / Q000187:drug effects*
D003374:Coumarins; D010936:Plant Extracts; D011480:Protease Inhibitors; C051122:wedelolactone; C051123:demethylwedelolactone; D014357:Trypsin