In vivo imaging with oligonucleotides for diagnosis and drug development.
Molecular imaging, the science that combines non-invasive in vivo imaging and molecular biology, has begun to use labelled oligonucleotides as radiotracers. Antisense oligonucleotides target gene expression at the RNA level, while aptamer oligonucleotides are designed to hit proteins of interest. Oligonucleotides for imaging cover a large range of applications, from the invention of new contrast agents for diagnosis to exquisite research tools for the development of new drugs.
Laboratoire d'expression des gènes, Service Hospitalier Frédéric Joliot, CEA, INSERM 0103, Orsay, France. tavitian@shfj.cea.fr
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Tavitian
D015195:Drug Design; D005767:Gastrointestinal Diseases / Q000175:diagnosis; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D009841:Oligonucleotides / Q000235:genetics; D016376:Oligonucleotides, Antisense; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed / Q000379:methods*
D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D019275:Radiopharmaceuticals