Influence of Eudragit NE 30 D blended with Eudragit L 30 D-55 on the release of phenylpropanolamine hydrochloride from coated pellets.
The objective of this study was to investigate the influence of Eudragit NE 30 D blended with Eudragit L 30 D-55 on the release of phenylpropanolamine hydrochloride (PPA x HCl) from coated pellets. The miscibility of Eudragit NE 30 D/L 30 D-55 blends at different ratios was studied by using differential scanning calorimetry. The release of PPA x HCl from pellets coated with Eudragit NE 30 D alone and a Eudragit NE 30 D/L 30 D-55 blend, when stored at 40 degrees C and 60 degrees C, was determined by UV spectroscopy. Eudragit NE 30 D and Eudragit L 30 D-55 were miscible in ratios greater than 4:1. The curing time that was required to reach an equilibrium state decreased with the addition of Eudragit L 30 D-55. The presence of Eudragit L 30 D-55 also produced a film coating that was less tacky, and a dispersion of Eudragit NE 30 D containing Eudragit L 30 D-55 (5:1) was shown to prevent agglomeration of the pellets during coating and storage.
Zheng
Weijia
W
College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA. wjzheng@mail.utexas.edu
McGinity
James W
JW
D002152:Calorimetry, Differential Scanning; D002482:Cellulose / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry*; D010665:Phenylpropanolamine / Q000008:administration & dosage* / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D012995:Solubility; D013997:Time Factors
D003692:Delayed-Action Preparations; C477852:Eudragit L 30 D-55; C477853:Eudragit NE 30-D; D005079:Excipients; D008689:Methacrylates; D011108:Polymers; D010665:Phenylpropanolamine; D002482:Cellulose; D011205:Povidone; C109691:microcrystalline cellulose