Effect of Garcinia cambogia extract on serum leptin and insulin in mice.
In this study we examined the effects of 3.3% Garcinia cambogia extract on 10% sucrose loading in mice for 4 weeks. Treatment was found to have no effect on body weight, fat pad weight or serum glucose level. On the other hand, serum total cholesterol, triglycerides, NEFA were observed. Levels of serum insulin and leptin, as well as the leptin/WAT ratio, were lower in the treated mice than in the control. These findings suggested that G. cambogia extract efficiently improved glucose metabolism and displayed leptin-like activity.
Laboratory of Advanced Animal and Marine Bioresources, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan. kohayamizu@fancl.co.jp
K
K
Hayamizu
H
H
Hirakawa
D
D
Oikawa
T
T
Nakanishi
T
T
Takagi
T
T
Tachibana
M
M
Furuse
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D002951:Citrates; D004032:Diet; D004040:Dietary Carbohydrates; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005638:Fruit; D029761:Garcinia cambogia; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000097:blood*; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D002951:Citrates; D004040:Dietary Carbohydrates; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D020738:Leptin; D010936:Plant Extracts; D014280:Triglycerides; C007999:hydroxycitric acid; D002784:Cholesterol