Lack of association between the HLA-A10 (A25), B18 and C2o haplotype and anaphylactoid purpura (AP).
In 41 patients with AP and 134 healthy relatives HLA haplotypes and total hemolytic complement and C2 concentrations were determined. Though complement levels were found in the lower normal range in none of the individuals studied, a genetically determined C2 deficient state could be established. No association between low C2 levels and the HLA haplotype A10(A25), B18 or an isolated A25 or B18 was observed. A comparison of phenotype frequencies of AP patients with controls showed no significant difference. Contingency table analysis of patients and control haplotypes showed a definite close association with HLA-A1, Bw22, A2, Bw16, and A29, B12.
Department of Blood Transfusion of the University of Cologne, Germany.
J
J
Krüger
W
W
Opferkuch
K G
KG
Evers
L
L
Bosecker
W
W
Haase
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003175:Complement C2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015234:HLA-A Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D011695:IgA Vasculitis / Q000235:genetics* / Q000276:immunology*; D007223:Infant; D008297:Male; D010641:Phenotype
D003175:Complement C2; D015234:HLA-A Antigens; C039682:HLA-A10 antigen