[Molecular construction (superstructures) with adjustable properties based on double-stranded nucleic acids].
Formation of molecular construction that consists of double-stranded molecules of nucleic acids (or synthetic polynucleotides) located at the distance 30-50 A in the spatial structure of particles of their cholesteric liquidcrystalline dispersion and crosslinked by polymeric chelate bridges is described. The resulting superstructure, which possesses peculiar physicochemical properties, could be used as integral biosensor whose properties depend on temperature, the presence of chemical or biologically active compounds of different nature, etc.
Evdokimov
Iu M
IuM
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia. yevdokim@eimb.ru
Salianov
V I
VI
Nechipurenko
Iu D
IuD
Skuridin
S G
SG
Zakharov
M A
MA
Spener
F
F
Palumbo
M
M
D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000378:metabolism; D001671:Biochemistry / Q000379:methods; D002627:Chemistry, Physical / Q000379:methods; D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D055095:Optics and Photonics
D000903:Antibiotics, Antineoplastic; D009696:Nucleic Acids; D004247:DNA