Familiality in simple and complex disease.
Establishing the existence of a genetic contribution to disease is the first step in identifying the underlying gene defect(s). This can present a considerable challenge, particularly in diseases where the genetic contribution is complex in nature. Clinically well-characterized cohorts and large inter-institutional collaborations will be required to identify genes involved in complex disease.
Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 10 Room 6C103, 9000 Rockville Pike, Bethesda, MD 20892 USA. singleta@mail.nih.gov
Andrew
A
Singleton
D005190:Family; D030342:Genetic Diseases, Inborn / Q000145:classification / Q000235:genetics*; D006801:Humans