Implications for the neural basis of social cognition for the study of schizophrenia.
OBJECTIVE
The study of social cognition in schizophrenia has received growing attention in recent years. At the same time, a large body of work has explored the neural basis of social cognition in both nonclinical and clinical groups, other than those with schizophrenia. The gap between these two literatures is considerable and may slow progress in creating a comprehensive social cognitive model of schizophrenia. This article attempts to bridge this gap by discussing how the neural basis of social cognition may inform future clinical research in schizophrenia.


METHODS
PsycINFO and MEDLINE were systematically searched for articles pertaining to the neural basis of social cognition and social cognition in schizophrenia. Relevant studies were obtained and synthesized into a comprehensive review and integrative formulation.


RESULTS
Striking parallels between these two areas of research were found.


CONCLUSIONS
These parallels might help to better elucidate the underlying mechanisms for social cognitive and social behavioral impairments in schizophrenia as well as provide potential targets for treatment and drug development.
Department of Psychology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599-3270, USA.
Amy E
AE
Pinkham
David L
DL
Penn
Diana O
DO
Perkins
Jeffrey
J
Lieberman
D002540:Cerebral Cortex / Q000502:physiology / Q000503:physiopathology*; D003071:Cognition / Q000502:physiology; D003463:Cues; D004644:Emotions / Q000502:physiology; D005149:Facial Expression; D005625:Frontal Lobe / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D008959:Models, Neurological; D008960:Models, Psychological; D017397:Prefrontal Cortex / Q000502:physiology / Q000503:physiopathology; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012919:Social Behavior; D012938:Social Perception