Gene expression studies of osteoporosis: implications for microarray research.
Osteoporosis is one of the most common bone-related disorders in the elderly. It is a complex disease, and largely determined genetically. Traditional gene expression studies have shown that osteoporosis has complex regulating mechanisms which are controlled by multiple inherent factors, such as hormones, cytokines, various receptors, etc. The complex nature of osteoporosis, and the large number of genes involved in its onset and development, suggest the use of the state of the art microarray technique as a powerful tool to unravel mechanisms underlying etiology of osteoporosis.
Dvornyk
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Osteoporosis Research Center, Creighton University, 601 N. 30th St., Suite 6730, Omaha, NE 68131, USA. dvornyk@creighton.edu
Recker
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RR
Deng
H-W
HW
D000368:Aged; D005260:Female; D005544:Forecasting; D005708:Gallium / Q000627:therapeutic use; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods* / Q000639:trends; D010024:Osteoporosis / Q000188:drug therapy / Q000235:genetics*; D015663:Osteoporosis, Postmenopausal / Q000235:genetics; D012313:RNA / Q000235:genetics; D014812:Vitamin K / Q000627:therapeutic use
D014812:Vitamin K; D012313:RNA; D005708:Gallium