Significance of an exaggerated meal-stimulated gastrin response in pathogenesis of Helicobacter pylori-negative duodenal ulcer.
The aim of this study was to clarify the pathogenesis of Helicobacter pylori-negative duodenal ulcer (DU) by investigating the meal-stimulated serum gastrin (SG) response. The subjects were 9 patients with H. pylori-negative DU, 28 H. pylori-positive DU, 11 H. pylori-positive volunteers, and 30 H. pylori-negative volunteers. Blood samples were taken before and after consumption of a test meal. The integrated 1-hr gastrin response (IGR) was taken to be the area under the SG time curve, calculated by the trapezoid method. H. pylori infection status was determined by histology, serology, and the [13C] urea breath test. The mean basal SG concentration was lower in the H. pylori-negative DU patients than in the H. pylori-positive DU patients, but an exaggerated IGR was observed in three patients (33.3%) with H. pylori-negative DU. In conclusion, our findings indicate that an exaggerated meal-stimulated gastrin response may contribute to the pathogenesis of H. pylori-negative DU.
Division of Gastroenterology, Department of Medicine, Kawasaki Medical School, Matsushima, Kurashiki, Japan.
Tomoari
T
Kamada
Ken
K
Haruma
Hiroaki
H
Kusunoki
Masaki
M
Miyamoto
Masanori
M
Ito
Yasuhiko
Y
Kitadai
Masaharu
M
Yoshihara
Kazuaki
K
Chayama
Kazumasa
K
Tahara
Yuzuru
Y
Kawamura
D000293:Adolescent; D000328:Adult; D001944:Breath Tests; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000503:physiopathology*; D004384:Duodenoscopy; D005260:Female; D005755:Gastrins / Q000097:blood*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood; D019518:Postprandial Period / Q000502:physiology*; D012307:Risk Factors
D005755:Gastrins; D020116:Pepsinogen A