Lactic dehydrogenase isoenzyme in cerebrospinal fluid of children with infantile spasms.
Increased levels of lactic dehydrogenase (LDH) in cerebrospinal fluid (CSF) have been reported in association with several intracranial pathologies. We studied LDH isoenzymes in the CSF of children with infantile spasms. CSF samples collected from 12 patients (aged 4-9 months) with infantile spasms were analyzed for total LDH isoenzymes activity, and were compared to samples from 15 normal children. Mean total LDH activity in the CSF was 34.62 +/- 6.52 U/l. Patients with infantile spasms had a lower LDH-1 percentage and higher LDH-3 percentage; the differences from the control group were statistically significant (p < 0.01). LDH-4 and LDH-5 had similar values in both groups. Infantile spasm is apparently associated with a distinct LDH isoenzyme pattern in the CSF. More studies are needed to confirm the rise in LDH-2, LDH-3 and to determine the optimum time of analysis.
Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tikva, Israel. nussim@clalit.org.il
Moshe
M
Nussinovitch
Daniella
D
Harel
Tali
T
Eidlitz-Markus
Jacob
J
Amir
Benjamin
B
Volovitz
D006801:Humans; D007223:Infant; D007527:Isoenzymes / Q000134:cerebrospinal fluid; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid*; D000080864:Lactate Dehydrogenase 5; D013036:Spasms, Infantile / Q000134:cerebrospinal fluid* / Q000201:enzymology
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; C409676:lactate dehydrogenase 2; C409677:lactate dehydrogenase 3; C409678:lactate dehydrogenase 4; D000080864:Lactate Dehydrogenase 5; C409667:lactate dehydrogenase 1