Impact of elevated ambient temperatures on the acute immune response to intensive endurance exercise.
To date, there has been little research examining how elevated ambient temperatures exert an additional effect on the acute immune response to endurance exercise. Seven endurance-trained, non-heat-acclimated men [mean (95% confidence interval): 29.7 (25.9-33.5) years, .VO(2max) 66.3 (61.3-71.3) ml.kg(-1).min(-1)] performed two 60-min treadmill runs (75% .VO(2max)) in two different environments (EX1: 18 degrees C/50% room temperature/relative humidity and EX2: 28 degrees C/50% room temperature/relative humidity) with a 7-day interval between the runs. Blood samples were drawn at rest and 0, 0.5, 3, 24, and 48 h after exercise. Compared to EX1, exercise-induced increases in core temperature, sweating rate, heart rate, plasma norepinephrine, cortisol, human growth hormone, and neutrophil and monocyte counts were significantly (5% level) more pronounced after EX2. In contrast, responses of plasma epinephrine, myeloperoxidase, interleukin (IL)-6 as well as lymphocyte counts were similar in EX1 and EX2. Plasma concentrations of IL-8 and C-reactive protein were affected by neither exercise nor by additional heat exposure. Our results suggest that the additional impact of elevated ambient temperatures on stress responses to endurance exercise in trained subjects seems to affect primarily the cardiocirculatory and hormonal systems, and resulting changes in neutrophil and monocyte cell-trafficking. In contrast, heat stress does not seem to exert large additional effects on the acute immune response to endurance exercise as performed in the present study.
Medizinische Universitätsklinik, Abteilung Rehabilitative und Präventive Sportmedizin, Universität Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany. niess@msm1.ukl.uni-freiburg.de
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Niess
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Fehrenbach
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Lehmann
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Opavsky
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Jesse
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Northoff
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Dickhuth
D000210:Acute-Phase Reaction / Q000209:etiology* / Q000276:immunology*; D000328:Adult; D001831:Body Temperature / Q000276:immunology*; D002097:C-Reactive Protein / Q000032:analysis; D018882:Heat Stress Disorders / Q000209:etiology* / Q000276:immunology*; D006358:Hot Temperature / Q000009:adverse effects*; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D018375:Neutrophil Activation / Q000276:immunology; D009195:Peroxidase / Q000097:blood; D010807:Physical Endurance / Q000276:immunology*; D012420:Running / Q000502:physiology
D015850:Interleukin-6; D016209:Interleukin-8; D019382:Human Growth Hormone; D002097:C-Reactive Protein; D009195:Peroxidase; D006854:Hydrocortisone