Mitral valve vegetation and cerebral emboli in a primary antiphospholipid syndrome patient who had hepatitis C virus infection: report of a case and review of the literature.
We report the case of 36-year-old woman who came to us with a history of recurrent miscarriages and who was later diagnosed as having primary antiphospholipid syndrome (PAPS) and chronic hepatitis C virus (HCV) infection. The patient was referred to us with generalised seizures; cranial MRI revealed multiple embolic infarcts in both frontal lobes and a focal cortical infarct in the left frontoparietal lobe. Her echocardiography showed mitral valve vegetation and insufficiency. The patient was put on oral anticoagulant therapy and during her 8-month follow-up period no thrombotic events occurred. We report this case because it was the first in which PAPS, valvular disease, a cerebral embolic event and HCV infection were coexistent in the same patient. We also review other cases in which there was valvular vegetation and a cerebral ischaemic event associated with PAPS.
Pamuk
O N
ON
Koca Sinan Mah, Sadik Ahmet Cad Varli Apt No: 25 Daire:2, Edirne, Turkey. onpamuk80@hotmail.com
Cakir
N
N
Soy
M
M
Aktoz
M
M
Celik
Y
Y
Akdemir
O
O
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000276:immunology*; D000925:Anticoagulants / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000276:immunology; D002220:Carbamazepine / Q000627:therapeutic use; D015150:Echocardiography, Doppler; D004696:Endocarditis / Q000150:complications* / Q000000981:diagnostic imaging; D004827:Epilepsy / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006526:Hepatitis C / Q000150:complications* / Q000276:immunology; D006801:Humans; D020766:Intracranial Embolism / Q000175:diagnosis / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology*; D014859:Warfarin / Q000627:therapeutic use
D017153:Antibodies, Anticardiolipin; D000925:Anticoagulants; D000927:Anticonvulsants; D002220:Carbamazepine; D014859:Warfarin