Total synthesis of debromoflustramine B via biomimetic alkylative cyclization.
[reaction: see text] The hexahydropyrrolo[2,3-b]indoline skeleton is readily accessed by the zinc triflate-mediated alkylation of tryptamine derivatives. The methodology was employed in a three-step total synthesis of debromoflustramine B.
Department of Chemistry, University of Southampton, Southampton SO17 1BJ, United Kingdom.
Gan Hup
GH
Tan
Xiuwen
X
Zhu
A
A
Ganesan