[Regulation of a new amino acids preparation on the expression of growth factors in traumatized rats].
The effect of a new amino acids formulas on wound healing and the expression of several growth factors in traumatized rats were investigated. Twenty-four male Wistar rats were randomly divided into control group, 17AA group and 20AA group after operation, and fed with rations containing tyrosine, a commercial amino acids (17AA), and a new amino acids formula(20AA) respectively. Body weight, dietary intake, the hydroyproline and tensile strength of wound were measured. At the same time, the expression of EGF, TGF beta 1 and bFGF in small intestine were also determined. The results showed that the levels of hydroyproline in sponge and tensile-strength of wound were higher in 20AA group than in 17AA group(P < 0.05). The orders of expression of EGF, TGF beta 1 and bFGF in small intestine were as follows: 20AA group > 17AA group > control group. It is concluded that the new amino acids preparations can enhance the expression of growth factors in small intestines and promote wound healing.
Institute of Hygiene and Environmental Medicine, Tianjin 300050, China.
Yugang
Y
Jiang
Changjiang
C
Guo
Jijun
J
Yang
Jingyu
J
Wei
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D016228:Endothelial Growth Factors / Q000096:biosynthesis* / Q000235:genetics; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis* / Q000235:genetics; D007421:Intestine, Small / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D016212:Transforming Growth Factor beta / Q000096:biosynthesis / Q000235:genetics; D053773:Transforming Growth Factor beta1; D014945:Wound Healing / Q000187:drug effects; D014947:Wounds and Injuries / Q000097:blood*
D000596:Amino Acids; D016228:Endothelial Growth Factors; D012333:RNA, Messenger; C508962:Tgfb1 protein, rat; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D016222:Fibroblast Growth Factor 2