The bacterial universal stress protein: function and regulation.
The universal stress protein A (UspA) superfamily encompasses an ancient and conserved group of proteins that are found in bacteria, Archea, fungi, flies and plants. The Escherichia coli UspA is produced in response to a large number of different environmental onslaughts and UspA is one of the most abundant proteins in growth-arrested cells. Although insights into the regulation of the E. coli uspA gene have been gained, the exact roles of the Usp proteins and Usp domains remain enigmatic; they appear, in some cases, to be linked to resistance to DNA-damaging agents and to respiratory uncouplers.
Department of Cell and Molecular Biology, Microbiology, Göteborg University, Medicinaregatan 9C, 413 90 Göteborg, Sweden.
Kristian
K
Kvint
Laurence
L
Nachin
Alfredo
A
Diez
Thomas
T
Nyström
D001426:Bacterial Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D001685:Biological Factors / Q000145:classification / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D006360:Heat-Shock Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D008957:Models, Genetic
D001426:Bacterial Proteins; D001685:Biological Factors; D029968:Escherichia coli Proteins; D006360:Heat-Shock Proteins; C078564:universal stress protein A, Bacteria