Antifungal activity of a thiophene polyine from Leuzea carthamoides.
The thiophene polyine (E)-2-[5-(hept-5-en-1,3-diynyl)-thien-2-yl]-ethan-1,2-diol was isolated from an ethanolic extract of underground parts of Leuzea carthamoides. The thiophene polyine demonstrated significant antifungal activity against all tested species.
Department of Pharmaceutical Botany and Ecology, Charles University, Faculty of Pharmacy, Heyrovského 1203, Hradec Králové 500 05, Czech Republic.
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Chobot
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Buchta
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Jahodárová
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Pour
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Opletal
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Jahodár
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Harant
D020095:Absidia / Q000187:drug effects; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001230:Aspergillus / Q000187:drug effects; D019659:Asteraceae; D002175:Candida / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013876:Thiophenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D010936:Plant Extracts; D013876:Thiophenes