Adenoma multiplicity in irradiated Apc(Min) mice is modified by chromosome 16 segments from BALB/c.
Ionizing radiation (IR) is a well-characterized carcinogen in humans and mice. The BALB/c mouse strain is unusually sensitive to IR-induced tissue damage and cancer development in a range of organs, suggestive of a partial defect in DNA damage response. This has been confirmed by finding BALB/c-specific functional polymorphism in Prkdc, a gene on mouse chromosome 16 that encodes the catalytic subunit of DNA-dependent protein kinase. Prkdc(BALB) has been associated with increased susceptibility to IR-induced mammary and lymphatic neoplasia. Here, we provide evidence that chromosome 16 segments from BALB/c interact with Apc(Min) (multiple intestinal neoplasia) and specifically enhance IR-induced adenoma development in the upper part of the small intestine.
Radiation Effects Department, National Radiological Protection Board, Chilton, Didcot, Oxon, OX11 0RQ, United Kingdom.
Natalie L
NL
Degg
Michael M
MM
Weil
Alan
A
Edwards
Jackie
J
Haines
Margaret
M
Coster
John
J
Moody
Michele
M
Ellender
Roger
R
Cox
Andrew
A
Silver
D000236:Adenoma / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D011125:Adenomatous Polyposis Coli / Q000201:enzymology / Q000235:genetics; D000818:Animals; D002874:Chromosome Mapping; D033481:Chromosomes, Mammalian / Q000235:genetics; D003043:Cocarcinogenesis; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D005260:Female; D007414:Intestinal Neoplasms / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D007421:Intestine, Small / Q000201:enzymology / Q000528:radiation effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009381:Neoplasms, Radiation-Induced / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D009687:Nuclear Proteins; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D051747:DNA-Activated Protein Kinase; C497264:Prkdc protein, mouse; D017346:Protein Serine-Threonine Kinases