Genome informatics: current status and future prospects.
This article reviews recent advances in genomics and informatics relevant to cardiovascular research. In particular, we review the status of (1) whole genome sequencing efforts in human, mouse, rat, zebrafish, and dog; (2) the development of data mining and analysis tools; (3) the launching of the National Heart, Lung, and Blood Institute Programs for Genomics Applications and Proteomics Initiative; (4) efforts to characterize the cardiac transcriptome and proteome; and (5) the current status of computational modeling of the cardiac myocyte. In each instance, we provide links to relevant sources of information on the World Wide Web and critical appraisals of the promises and the challenges of an expanding and diverse information landscape.
The Whitaker Biomedical Engineering Institute and Center for Cardiovascular Bioinformatics and Modeling, The Johns Hopkins University School of Medicine, Baltimore, Md 21218, USA. rwinslow@bme.jhu.edu
Raimond L
RL
Winslow
Mark S
MS
Boguski
D000818:Animals; D019295:Computational Biology / Q000639:trends*; D004285:Dogs; D005544:Forecasting; D023281:Genomics / Q000639:trends*; D006801:Humans; D020407:Internet; D051379:Mice; D008955:Models, Cardiovascular; D009206:Myocardium / Q000378:metabolism*; D040901:Proteomics / Q000639:trends; D051381:Rats; D014158:Transcription, Genetic