Subretinal organization in stage 5 retinopathy of prematurity.
BACKGROUND
The subretinal organization (SRO) seen in patients who undergo vitrectomy for stage 5 retinopathy of prematurity has not previously been characterized. We report our observations of SRO and correlate its development with previous laser and cryotreatment for neovascular disease.


METHODS
We surveyed data from 426 eyes in a retrospective chart review of 263 patients that underwent open-sky vitrectomy for stage 5 retinopathy of prematurity.


RESULTS
Of 426 eyes evaluated, 130 eyes received laser, cryo, or a combination of both treatments. In 44 eyes (10.3%), SRO was observed and considered the cause of incomplete retinal attachment. Three forms of SRO were identified: subretinal bands (63.6%), subretinal plaques (15.9%), and diffuse SRO (18.2%). One patient had both a band and a plaque. SRO developed in 24 eyes after cryotreatment, 3 after laser, and 2 after combination cryo and laser treatment. Fewer untreated eyes than cryotreatment eyes developed SRO (15 of 296 eyes, 5.1%; ( P=0.0001). Eyes without laser or cryotreatment had a 5.1% frequency of developing SRO.


CONCLUSIONS
Subretinal organization, a previously uncharacterized entity in retinopathy of prematurity, was most frequently identified in the form of subretinal band formation. SRO was identified in 10.3% of all stage 5 eyes evaluated, and was associated with incomplete retinal reattachment in all cases.
Steidl
Scott M
SM
Department of Ophthalmology, Suite 420, University of Maryland School of Medicine, 419 West Redwood Street, Baltimore, MD 21201-1734, USA. ssteidl@som.umaryland.edu
Hirose
Tatsuo
T
D003452:Cryosurgery; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D017075:Laser Coagulation; D012160:Retina / Q000473:pathology*; D012163:Retinal Detachment / Q000145:classification / Q000209:etiology* / Q000601:surgery; D015861:Retinal Neovascularization / Q000145:classification / Q000209:etiology* / Q000601:surgery; D012178:Retinopathy of Prematurity / Q000145:classification / Q000150:complications* / Q000601:surgery; D012189:Retrospective Studies; D014821:Vitrectomy