[Pleural effusion as a first sign of Ig D lambda multiple myeloma].
Immunoglobulin D (IgD) multiple myeloma is rare, accounting for less than 2% of all patients with multiple myeloma. The main presenting features are bone pain in 70% of patients. Extramedullary involvement is less common. We report a case of Ig D lambda multiple myeloma in a 74-year-old man that was revealed by pleural effusion and dyspnea. This effusion was found to be caused by multiple myeloma after electrophoretic and cytologic assays. The patient received a course of chemotherapy with melphalan and prednisone. The patient died one month later with signs of septic shock. Pleural effusion as a first sign of Ig D multiple myeloma is rarely described and the prognosis associated with such a localisation is very poor.
Laboratoire de Biochimie et Hormonologie, Hôpital Tenon, Paris.
Mustapha
M
Maachi
Soraya
S
Fellahi
Marie-Emilienne
ME
Diop
Thierry
T
Francois
Jacqueline
J
Capeau
Jean-Philippe
JP
Bastard
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004417:Dyspnea / Q000209:etiology; D006801:Humans; D007122:Immunoelectrophoresis; D007072:Immunoglobulin D / Q000032:analysis*; D007146:Immunoglobulin lambda-Chains / Q000032:analysis*; D008297:Male; D008558:Melphalan / Q000008:administration & dosage / Q000627:therapeutic use; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D010996:Pleural Effusion / Q000209:etiology*; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D018906:Antineoplastic Agents, Alkylating; D007072:Immunoglobulin D; D007146:Immunoglobulin lambda-Chains; D008558:Melphalan; D011241:Prednisone