Leukemoid reaction response to chemotherapy and radiotherapy in a patient with cervical carcinoma.
A white blood cell count more than 50 x 10(9)/l associated with a cause outside the bone marrow is termed a leukemoid reaction. Although it simulates leukemia, most of its causes are benign. Malignancy as a cause of a leukemoid reaction is still a medical dilemma. It is thought to be attributed to granulocyte colony-stimulating factor (G-CSF) secreted by the tumor cells. To our knowledge this is the first time a leukemoid reaction has been reported in association with cervical cancer. We even managed to monitor the leukemoid reaction response to chemotherapy and radiotherapy.
Nimieri
H S
HS
Department of Internal Medicine, Mercy Fitzgerald Hospital, 1500 Lansdowne Ave., Darby, PA 19018, USA.
Makoni
S N
SN
Madziwa
F H
FH
Nemiary
D S
DS
D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects; D014408:Biomarkers, Tumor / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000150:complications / Q000175:diagnosis; D003131:Combined Modality Therapy / Q000009:adverse effects; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007955:Leukemoid Reaction / Q000209:etiology*; D007958:Leukocyte Count; D011878:Radiotherapy / Q000009:adverse effects; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000150:complications / Q000175:diagnosis*
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor