Synthesis, conformational analysis and free radical scavenging activity of some new spiropyranoquinolinones.
A series of novel spiroadamantyl- and spirocyclical substituted pyranoquinolin-2-ones were synthesized and the conformation of the pyran ring was investigated. The free radical scavenging activity of the synthesized compounds was determined by their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH). All compounds tested scavenged the DPPH radical and among them derivatives possessing extended conjugation showed the highest activity.
Panteleon
Vassiliki
V
Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens, Greece.
Marakos
Panagiotis
P
Pouli
Nicole
N
Mikros
Emmanuel
E
Andreadou
Ioanna
I
D001713:Biphenyl Compounds; D002855:Chromatography, Thin Layer; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology*; D006860:Hydrogen Bonding; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010851:Picrates / Q000737:chemistry; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D010851:Picrates; D015363:Quinolones; D013141:Spiro Compounds; C004931:1,1-diphenyl-2-picrylhydrazyl