[Apoptosis in neuronal structures and the role of neurotrophic growth factors. Biochemical mechanisms of brain derived peptide preparations].
Phenomenology of neurodegenerative disorders of any genesis corresponds to modern concepts of apoptosis as a morphobiochemical mechanism for programmed death of certain nervous cell populations. Neuroapoptosis is assumed to be a basic cause of all kind of neuropathology. Neuropeptides synthesized in certain brain regions and neurotrophic growth factors playing an important role in brain function control get involved in neurodestructive process realization as pro- or antiapoptotic components. On the basis of above concepts it is suggested that therapeutic efficacy of cerebrolysin, successfully used for therapy of wide spectrum of ischemic, neurodegenerative and other brain pathologies lies in inhibiting influence on apoptosis-dependent processes in the nervous cell. This medication including a neuropeptide and neurotrophic factors complex has many targets, which may be used for neuroapoptosis correction on different stages of pathological process.
O A
OA
Gomazkov
D000596:Amino Acids / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D001927:Brain Diseases / Q000188:drug therapy* / Q000503:physiopathology; D019208:Brain-Derived Neurotrophic Factor / Q000627:therapeutic use; D006801:Humans; D009479:Neuropeptides / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000494:pharmacology*
D000596:Amino Acids; D019208:Brain-Derived Neurotrophic Factor; D009479:Neuropeptides; D018696:Neuroprotective Agents; C006952:cerebrolysin