Functional modulation of the sodium pump: the regulatory proteins "Fixit".
Proteins of the FXYD family act as tissue-specific regulators of the Na-K-ATPase. They are small hydrophobic type I proteins with a single-transmembrane span containing an extracellular invariant FXYD sequence. FXYD proteins are not an integral part of the Na-K-ATPase but function to modulate its catalytic properties by molecular interactions with specific Na-K-ATPase domains.
Cornelius
Flemming
F
Department of Biophysics, University of Aarhus, DK-8000 Aarhus, Denmark.
Mahmmoud
Yasser A
YA
D000595:Amino Acid Sequence / Q000235:genetics; D000818:Animals; D002384:Catalysis; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology*; D008969:Molecular Sequence Data; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism / Q000502:physiology*
D008565:Membrane Proteins; D000254:Sodium-Potassium-Exchanging ATPase