Depression in women with polycystic ovary syndrome: clinical and biochemical correlates.
BACKGROUND
We assessed the prevalence of mood disturbance among women with prospectively documented polycystic ovary syndrome (PCOS).


METHODS
Thirty-two women with PCOS completed the Center for Epidemiological Studies-Depression Rating Scale (CES-D). Clinical and biochemical characteristics were assessed.


RESULTS
Sixteen women had CES-D scores indicative of depression. Depression was associated with greater insulin resistance (P=0.02) and higher body mass index (P=0.05). Women receiving oral contraceptives for the treatment of PCOS were less depressed than patients not receiving treatment (P=0.03).


CONCLUSIONS
Possible selection bias, use of a screening tool alone without further diagnostic evaluation of depression, small samples size and lack of direct comparison with an age matched control group, should be considered in interpretation of these results.


CONCLUSIONS
Findings suggest a high prevalence of depression among women with PCOS, and an association between depression and PCOS markers.
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Mood Disorders Research Program, 300 Medical Plaza, Suite 1544, Los Angeles, CA 90095-7057, USA. nrasgon@mednet.ucla.edu
Natalie L
NL
Rasgon
Rekha C
RC
Rao
Sun
S
Hwang
Lori L
LL
Altshuler
Shana
S
Elman
Joni
J
Zuckerbrow-Miller
Stanley G
SG
Korenman
D000328:Adult; D015992:Body Mass Index; D003865:Major Depressive Disorder / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000453:epidemiology*; D015995:Prevalence; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood
D013739:Testosterone