Primary hyperhidrosis--evidence for autosomal dominant inheritance.
Primary hyperhidrosis is a neurogenic disorder of unknown cause characterized by excessive sweating in the palmar surface of the hands, armpits, groin and feet. In the course of a therapeutic trial for primary hyperhidrosis, 62 % of patients reported a positive family history. Examination of these pedigrees demonstrated a sibling recurrence risk of lambdas = 29-48 and an offspring recurrence risk of lambdao = 41-68 indicating that hyperhidrosis can be an inherited condition. The pattern of inheritance suggests an autosomal dominant mode of transmission with incomplete disease penetrance.
Kaufmann
Horacio
H
Dept. of Neurology, Mount Sinai School of Medicine, New York, USA.
Saadia
Daniela
D
Polin
Charlene
C
Hague
Stephen
S
Singleton
Amanda
A
Singleton
Andrew
A
D005260:Female; D005799:Genes, Dominant; D006225:Hand; D006801:Humans; D006945:Hyperhidrosis / Q000235:genetics*; D008297:Male; D010375:Pedigree