The current status of Paget's disease of the bone.
Paget's disease is a metabolic bone disease characterized by abnormalities of bone turnover, structure and architecture. The disease is of unknown aetiology, although both genetic and environmental factors have been implicated. Treatment is indicated for patients with active disease and currently bisphosphonates are the first-choice management option.
Keen
Richard W
RW
Metabolic Unit, Royal National Orthopaedic Hospital, Stanmore, Middlesex HA7 4LP.
D016723:Bone Remodeling / Q000502:physiology; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D010001:Osteitis Deformans / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
D004164:Diphosphonates