A patient with Crimean-Congo hemorrhagic fever serologically diagnosed by recombinant nucleoprotein-based antibody detection systems.
We treated a male patient with Crimean-Congo hemorrhagic fever (CCHF). The diagnosis of CCHF was confirmed by reverse transcription-PCR and recombinant nucleoprotein (rNP)-based immunoglobulin G (IgG) and IgM capture enzyme-linked immunosorbent assays of serially collected serum samples. The patient was treated with intravenous ribavirin and recovered with no consequences. The study indicates that rNP-based CCHF virus antibody detection systems are useful for confirming CCHF virus infections. This case also suggests that intravenous ribavirin therapy may be promising for the treatment of CCHF patients.
Second Division of Viral Hemorrhagic Fever, Institute of Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, People's Republic of China.
Qing
Q
Tang
Masayuki
M
Saijo
Yuzhen
Y
Zhang
Muer
M
Asiguma
Dong
D
Tianshu
Lei
L
Han
Bawudong
B
Shimayi
Akihiko
A
Maeda
Ichiro
I
Kurane
Shigeru
S
Morikawa
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000276:immunology; D006479:Hemorrhagic Fever, Crimean / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D009698:Nucleoproteins; D012367:RNA, Viral / Q000097:blood; D011994:Recombinant Proteins; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012254:Ribavirin / Q000627:therapeutic use; D012698:Serologic Tests
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009698:Nucleoproteins; D012367:RNA, Viral; D011994:Recombinant Proteins; D012254:Ribavirin