Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls.
Neurotrophins like brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are thought to play an important role in neuronal repair and plasticity. Recent experimental evidence suggests neuroprotective effects of these proteins in multiple sclerosis (MS). We investigated the response of serum NGF and BDNF concentrations to standardized acute exercise in MS patients and controls. Basal NGF levels were significantly elevated in MS. Thirty minutes of moderate exercise significantly induced BDNF production in MS patients and controls, but no differential effects were seen. We conclude that moderate exercise can be used to induce neutrophin production in humans. This may mediate beneficial effects of physical exercise in MS reported recently.
Gold
Stefan M
SM
Department of Neurology, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. gold@uke.uni-hamburg.de
Schulz
Karl-Heinz
KH
Hartmann
Sten
S
Mladek
Mila
M
Lang
Undine E
UE
Hellweg
Rainer
R
Reer
Rüdiger
R
Braumann
Klaus-Michael
KM
Heesen
Christoph
C
D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D005080:Exercise Test / Q000592:standards / Q000706:statistics & numerical data; D005260:Female; D006339:Heart Rate; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood* / Q000503:physiopathology*; D020932:Nerve Growth Factor / Q000097:blood*; D012737:Sex Factors; D013997:Time Factors
D019208:Brain-Derived Neurotrophic Factor; D019344:Lactic Acid; D020932:Nerve Growth Factor