The effect of intranasal desmopressin on nocturnal waking in urination in multiple system atrophy patients with nocturnal polyuria.
Nocturnal waking in urination (nocturia) is a common feature in patients with multiple system atrophy (MSA). Degeneration of arginine vasopressin (AVP) neurons in the suprachiasmatic nucleus in this disorder may lead to nocturnal polyuria, which has been treated with intramuscular desmopressin. We also prescribed 5 microg of intranasal desmopressin once a night in 3 MSA patients, who had nocturnal polyuria with abnormal circadian rhythm of the plasma AVP. During the treatment, all patients showed an improvement in their nocturia without serious adverse effects.
Neurology Department, Chiba University, 1-8-1 Inohana Chuo-Ku, Chiba 260-8670, Japan. sakaki@med.m.chiba-u.ac.jp
Ryuji
R
Sakakibara
Shinji
S
Matsuda
Tomoyuki
T
Uchiyama
Mitsuharu
M
Yoshiyama
Tomonori
T
Yamanishi
Takamichi
T
Hattori
D000281:Administration, Intranasal; D000368:Aged; D002940:Circadian Rhythm; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000503:physiopathology*; D011141:Polyuria / Q000188:drug therapy / Q000209:etiology*; D012076:Renal Agents / Q000627:therapeutic use
D012076:Renal Agents; D003894:Deamino Arginine Vasopressin