Comparison of changes in uterine contraction frequency after ovulation in the menstrual cycle and in in vitro fertilization cycles.
OBJECTIVE
To compare changes in uterine contraction (UC) frequency occurring after ovulation in the menstrual cycle and in IVF and to clarify UC anomalies encountered in IVF.


METHODS
Prospective crossover trial.


METHODS
University infertility clinic.


METHODS
Six women seeking IVF for male factor infertility having regular menstrual cycles were studied during the menstrual cycle and IVF.


METHODS
Identification of LH surge in the menstrual cycle. Measurement of plasma E(2) and P levels and assessment of UC frequency by direct ultrasound visualization on the day of LH surge in the menstrual cycle and the day of hCG administration in IVF and every 2 days thereafter for 6 days.


METHODS
Uterine contraction (UC) frequency and plasma E(2) and P levels.


RESULTS
UC frequency was similar on the day of LH surge (5/minute) and hCG administration (5.3/minute). Establishment of uteroquiescence was more prompt in the menstrual cycle than in IVF, with lower UC frequency 4 days after LH surge compared with 4 days after hCG, while E(2) and P levels were higher in IVF. Six days after LH surge/hCG administration, UC frequency was low in the menstrual cycle and in IVF.


CONCLUSIONS
High UC frequency in IVF at the time of ET results from delayed establishment of uteroquiescence after ovulation in IVF as compared with the menstrual cycle. In IVF, low UC frequency 6 days after hCG may contribute to the higher pregnancy rates observed with blastocyst transfers.
Department of Obstetrics and Gynecology and Reproductive Medicine, CHU de Grenoble,., Grenoble, France. ddeziegler@compuserve.com
Jean Marc
JM
Ayoubi
Manuela
M
Epiney
Pierre Alain
PA
Brioschi
Renato
R
Fanchin
Didier
D
Chardonnens
Dominique
D
de Ziegler
D000328:Adult; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle; D010060:Ovulation; D011446:Prospective Studies; D014590:Uterine Contraction
D006063:Chorionic Gonadotropin; D007986:Luteinizing Hormone