Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls.
Neurotrophins like brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are thought to play an important role in neuronal repair and plasticity. Recent experimental evidence suggests neuroprotective effects of these proteins in multiple sclerosis (MS). We investigated the response of serum NGF and BDNF concentrations to standardized acute exercise in MS patients and controls. Basal NGF levels were significantly elevated in MS. Thirty minutes of moderate exercise significantly induced BDNF production in MS patients and controls, but no differential effects were seen. We conclude that moderate exercise can be used to induce neutrophin production in humans. This may mediate beneficial effects of physical exercise in MS reported recently.
Department of Neurology, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. gold@uke.uni-hamburg.de
Stefan M
SM
Gold
Karl-Heinz
KH
Schulz
Sten
S
Hartmann
Mila
M
Mladek
Undine E
UE
Lang
Rainer
R
Hellweg
Rüdiger
R
Reer
Klaus-Michael
KM
Braumann
Christoph
C
Heesen
D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D005080:Exercise Test / Q000592:standards / Q000706:statistics & numerical data; D005260:Female; D006339:Heart Rate; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood* / Q000503:physiopathology*; D020932:Nerve Growth Factor / Q000097:blood*; D012737:Sex Factors; D013997:Time Factors
D019208:Brain-Derived Neurotrophic Factor; D019344:Lactic Acid; D020932:Nerve Growth Factor