The role of relB in regulating the adaptive immune response.
Dendritic cells (DCs), which represent a key type of antigen-presenting cell (APC), are important for the development of innate and adaptive immunity. DCs are involved in T cell activation in at least two main ways: priming via direct processing/presentation of soluble antigen taken up from the microenvironment (conventional priming), and processing/presentation of antigen released from other cells (cross-priming). relB, a component of the NF-kappaB complex of transcription factors, is a critical regulator of the differentiation of DCs. In mice, lack of relB impairs DCs derived from bone marrow both in number and function. Here relB (-/-) bone marrow chimera mice is used to study the APC function of residual DCs in presentation of soluble antigen and cross-priming. It is found that the DCs in these mice are profoundly deficient in their ability to both prime and cross-prime T cell responses. It was concluded that the relB gene is involved in regulating the APC function of DCs in vivo.
Zanetti
Maurizio
M
Department of Medicine and the Cancer Center, University of California, San Diego, La Jolla, California 92093-0837, USA. mzanetti@ucsd.edu
Castiglioni
Paola
P
Schoenberger
Stephen
S
Gerloni
Mara
M
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D007111:Immunity, Cellular / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D051841:Transcription Factor RelB; D014157:Transcription Factors / Q000502:physiology*
D011518:Proto-Oncogene Proteins; C497594:Relb protein, mouse; D014157:Transcription Factors; D051841:Transcription Factor RelB