Kinetics and significance of serum hepatitis C virus core antigen in patients with acute hepatitis C.
An immunoassay detecting hepatitis C virus core antigen was evaluated for its ability to predict clinical outcome in a series of patients with acute hepatitis C. In subjects who cleared the virus, core antigen was no longer detectable within 16 weeks of onset, whereas considerable fluctuations were noted among patients progressing to chronic hepatitis, one of whom showed consistently negative values despite the intermittent presence of viral RNA.
Laboratori di Ricerca-Area Infettivologica and Dipartimento di Malattie Infettive, IRCCS Policlinico, San Matteo, and University of Pavia, Italy.
Agostino
A
Cividini
Antonella
A
Cerino
Alba
A
Muzzi
Milena
M
Furione
Chiara
C
Rebucci
Laura
L
Segagni
Marta
M
Gatti
Vincenzo
V
Barnaba
Mario U
MU
Mondelli
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D005260:Female; D006526:Hepatitis C / Q000201:enzymology / Q000821:virology*; D018936:Hepatitis C Antigens / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012367:RNA, Viral / Q000097:blood
D018936:Hepatitis C Antigens; D012367:RNA, Viral; D000410:Alanine Transaminase