Social stress affects migration of blood T cells into lymphoid organs.
The effect of social confrontation stress on the normal distribution of blood T cells into lymphoid organs and some other body tissues was studied. Social stress was induced by placing a male Fischer 344 (F334) rat into the home cage of a resident opponent. 51Cr-labeled blood T cells isolated from syngeneic donor, were intravenously injected into recipients immediately before confrontation. The accumulation of 51Cr-labeled T cells in the spleen, mesenteric and cervical lymph nodes 24 h after injection was about 30% lower in socially stressed than in control males. Substantially higher localization was observed in the bone marrow of socially stressed males.
Stefanski
Volker
V
Department of Animal Physiology, University of Bayreuth, 95440 Bayreuth, Germany. volker.stefanski@uni-bayreuth.de
Peschel
André
A
Reber
Stefan
S
D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D002860:Chromium Radioisotopes / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D004291:Dominance-Subordination; D005260:Female; D008168:Lung / Q000166:cytology / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008221:Lymphoid Tissue / Q000166:cytology* / Q000276:immunology; D008297:Male; D008643:Mesentery; D009333:Neck; D051381:Rats; D011916:Rats, Inbred F344; D020318:Rats, Long-Evans; D012931:Social Environment; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013315:Stress, Psychological / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000637:transplantation
D002860:Chromium Radioisotopes; D003345:Corticosterone