Derivation of lung epithelium from bone marrow cells.
Recent studies demonstrate the capacity of BM-derived cells to engraft as differentiated cells of a variety of organs, including lung. In this paper, we review the current state-of-the-art in this area. We also summarize our work demonstrating that cultured adherent marrow cells can serve as progenitors of lung alveolar epithelium.
Kotton
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DN
The Pulmonary Center, Boston University School of Medicine, MA 02118, USA.
Fine
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D000818:Animals; D051402:Aquaporin 5; D020346:Aquaporins / Q000378:metabolism; D015415:Biomarkers; D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D048429:Cell Size / Q000502:physiology; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000378:metabolism; D051542:Hepatocyte Nuclear Factor 3-beta; D008168:Lung / Q000166:cytology / Q000196:embryology* / Q000502:physiology*; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D009687:Nuclear Proteins / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D020545:Respiratory Mucosa / Q000166:cytology / Q000196:embryology* / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000378:metabolism; D014598:Uteroglobin; D000098853:Podoplanin
D051402:Aquaporin 5; D020346:Aquaporins; D015415:Biomarkers; D004268:DNA-Binding Proteins; D051542:Hepatocyte Nuclear Factor 3-beta; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D011506:Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D014598:Uteroglobin; C496038:Aqp5 protein, mouse; C496503:Foxa2 protein, mouse; C490441:Pdpn protein, mouse; D000098853:Podoplanin; C556390:Scgb1a1 protein, mouse