Usefulness of urinary antigen detection by an immunochromatographic test for diagnosis of pneumococcal pneumonia in children.
We evaluated an immunochromatographic assay detecting pneumococcal antigen in urine samples from children diagnosed with pneumococcal pneumonia. The sensitivity and specificity of the immunochromatographic test with nonconcentrated urine (NCU) were 86.7 and 62.9%, respectively; with concentrated urine (CU), they were 100 and 11.7%, respectively. Pneumococcal antigen was also detected in 42.5% of NCU and 87.1% of CU samples from nasopharyngeal carriers. This is a nonspecific test for the diagnosis of pneumococcal pneumonia in children, particularly the very young.
Servei de Microbiologia, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Barcelona, Spain. jadoming@ns.hugtip.scs.es
J
J
Domínguez
S
S
Blanco
C
C
Rodrigo
M
M
Azuara
N
N
Galí
A
A
Mainou
A
A
Esteve
A
A
Castellví
C
C
Prat
L
L
Matas
V
V
Ausina
D000293:Adolescent; D000942:Antigens, Bacterial / Q000652:urine*; D002353:Carrier State / Q000175:diagnosis / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D002845:Chromatography / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods* / Q000706:statistics & numerical data; D007223:Infant; D008297:Male; D009305:Nasopharynx / Q000382:microbiology; D011018:Pneumonia, Pneumococcal / Q000175:diagnosis* / Q000382:microbiology; D012680:Sensitivity and Specificity; D013296:Streptococcus pneumoniae / Q000276:immunology* / Q000302:isolation & purification
D000942:Antigens, Bacterial