Synthesis and evaluation of cytotoxicity of stilbene analogues.
Resveratrol analogs were newly synthesized and evaluated for cytotoxicity in cultured human lung and colon cancer cells. 3,5,4-Trimethoxy-trans-stilbene and 3,5,2',4'-tetramethoxy-trans-stilbene were found to be more potent rather than resveratrol. 3,4,5-Trimethoxy-4'-bromo-cis-stilbene was the most active among the test compounds.
Lee
Sang Kook
SK
College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, Korea. sklee@ewha.ac.kr
Nam
Kyung Ae
KA
Hoe
Yeon Hoi
YH
Min
Hye-Young
HY
Kim
Eun-Young
EY
Ko
Hyojin
H
Song
Soyoung
S
Lee
Taeho
T
Kim
Sanghee
S
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000473:pathology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D066298:In Vitro Techniques; D008175:Lung Neoplasms / Q000473:pathology; D010936:Plant Extracts / Q000138:chemical synthesis* / Q000494:pharmacology; D000077185:Resveratrol; D012717:Sesquiterpenes; D013267:Stilbenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013729:Terpenes; D014407:Tumor Cells, Cultured; D000094162:Phytoalexins
D000970:Antineoplastic Agents; D010936:Plant Extracts; D012717:Sesquiterpenes; D013267:Stilbenes; D013729:Terpenes; D000077185:Resveratrol; D000094162:Phytoalexins