Protective effect of keratinocyte growth factor against lung abnormalities associated with hyperoxia in prematurely born rats.
We used a prematurely born rat/hyperoxia model of bronchopulmonary dysplasia (BPD) to test whether keratinocyte growth factor (KGF) treatment would protect against the development of several serious (cardio-)pulmonary complications of early life exposure to hyperoxia. KGF significantly protected against hyperoxic lethality (13-day survival rate = 50/64 (78%) for the O(2)-KGF vs. 29/66 (44%) for the O(2)-saline group, p < 0.001). Although KGF failed to protect against hyperoxic inhibition of normal postnatal alveoli formation and early pulmonary fibrosis, KGF consistently had a significant protective/preventive effect against the development of pulmonary hypertension during hyperoxia as reflected in comparative right ventricular hypertrophy: mean increase = +35% above normal for the O(2)-saline group vs. +3% for the O(2)-KGF premature rat group (p < 0.01).
Frank
Lee
L
Pulmonary Division, University of Miami School of Medicine, Miami, FL 33101, USA. lfrank@med.miami.edu
D000818:Animals; D000831:Animals, Newborn; D001997:Bronchopulmonary Dysplasia / Q000209:etiology / Q000517:prevention & control; D004195:Disease Models, Animal; D005260:Female; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors / Q000008:administration & dosage* / Q000502:physiology; D005865:Gestational Age; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D018496:Hyperoxia / Q000150:complications* / Q000401:mortality; D006976:Hypertension, Pulmonary / Q000517:prevention & control; D007231:Infant, Newborn; D008168:Lung / Q000201:enzymology; D008171:Lung Diseases / Q000209:etiology / Q000517:prevention & control*; D010100:Oxygen / Q000008:administration & dosage / Q000633:toxicity; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D015996:Survival Rate
C496453:FGF7 protein, human; C496455:Fgf7 protein, rat; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors; D005979:Glutathione Peroxidase; D010100:Oxygen