Mesial temporal sclerosis--a late complication in four allogeneic pediatric recipients with persistent seizures after an acute episode of cyclosporine-A neurotoxicity.
Mesial temporal sclerosis (MTS) is a common finding in patients with intractable temporal lobe epilepsy (TLE). In this report, we retrospectively reviewed the neuroimaging results of four children who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), and who developed recurrent, partial, intractable seizures following a first event caused by cyclosporine-A (CSA) neurotoxicity. Neuroradiologic findings of MTS were demonstrated in all these patients. We suggest that MTS may be a consequence of CSA neurotoxicity, which induces repeated seizures, associated with other predisposing conditions, as well as being a consequence of the underlying disease and its treatment, and of severe graft-versus-host disease (GvHD).
Department of Hematology and Oncology, Bone Marrow Transplant Unit, G. Gaslini Children's Research Institute, Genova, Italy.
M
M
Faraci
E
E
Lanino
S
S
Dallorso
G
G
Morreale
B
B
Cappelli
R
R
Gaggero
G
G
Dini
R
R
Haupt
M P
MP
Fondelli
D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000009:adverse effects*; D004833:Epilepsy, Temporal Lobe / Q000209:etiology* / Q000473:pathology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000628:therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007223:Infant; D008297:Male; D009498:Neurotoxins / Q000009:adverse effects; D010024:Osteoporosis / Q000628:therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012598:Sclerosis; D012640:Seizures / Q000209:etiology; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D019172:Transplantation Conditioning / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D009498:Neurotoxins; D016572:Cyclosporine