Highly enantioselective reductive amination of simple aryl ketones catalyzed by Ir-f-Binaphane in the presence of titanium(IV) isopropoxide and iodine.
Using an Ir-f-Binaphane complex as the catalyst, complete conversions and high enantioselectivies (up to 96% ee) were achieved in the asymmetric reductive amination of aryl ketones in the presence of Ti(O(i)()Pr)(4) and I(2). A simple and efficient method of synthesizing chiral primary amines has been realized.
Department of Chemistry, The Pennsylvania State University, University Park 16802, USA.
Yongxiang
Y
Chi
Yong-Gui
YG
Zhou
Xumu
X
Zhang
D000586:Amination; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007202:Indicators and Reagents; D007455:Iodine / Q000737:chemistry; D007495:Iridium / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
D000588:Amines; D007202:Indicators and Reagents; D007659:Ketones; D009942:Organometallic Compounds; D007495:Iridium; C102815:titanium isopropoxide; D007455:Iodine; D014025:Titanium