Unusual MR spectroscopic imaging pattern of an astrocytoma: lack of elevated choline and high myo-inositol and glycine levels.
We present the case of a patient with an MR imaging study showing an ill-defined intra-axial mass in the right insula and frontal lobe. The mass showed high signal intensity on T2-weighted and fluid-attenuated inversion recovery images and an unusual proton MR spectroscopic imaging pattern characterized by the presence of high levels of myo-inositol/glycine, no significant elevation of choline, and mildly reduced N-acetylaspartate. The histopathologic diagnosis was of diffuse astrocytoma with oligodendroglial components (World Health Organization grade II).
University of North Carolina School of Medicine, Chapel Hill 27599, USA.
Ana
A
Londoño
Mauricio
M
Castillo
Diane
D
Armao
Lester
L
Kwock
Kinuko
K
Suzuki
D000328:Adult; D001254:Astrocytoma / Q000737:chemistry / Q000175:diagnosis*; D001932:Brain Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D002794:Choline / Q000032:analysis*; D005998:Glycine / Q000032:analysis*; D006801:Humans; D007294:Inositol / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008297:Male
D007294:Inositol; D002794:Choline; D005998:Glycine