Thresholds for detecting and characterizing focal lesions using steady-state MR elastography.
An objective contrast-detail analysis was performed in this study to assess the low contrast detectability of a clinical prototype harmonic magnetic resonance elastographic imaging system. Elastographic imaging was performed on gelatin phantoms containing spherical inclusions of varying size and modulus contrast. The results demonstrate that lesions as small as 5 mm can be detected with a minimum modulus contrast of 14 dB. However, the shear modulus of such small lesions was not accurately recovered. In general, the shear modulus of larger focal lesions was accurately (i.e., within 25% of the true value) recovered. The minimum modulus contrast needed to detect focal lesions was observed to decrease with increasing lesion size.
Department of Radiology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA. Marvin.M.Doyley@Dartmouth.edu
Marvin M
MM
Doyley
John B
JB
Weaver
Elijah E W
EE
Van Houten
Francis E
FE
Kennedy
Keith D
KD
Paulsen
D000465:Algorithms; D004548:Elasticity; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009038:Motion; D009369:Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology*; D019047:Phantoms, Imaging; D010812:Physical Stimulation / Q000295:instrumentation / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D033081:Shear Strength; D013314:Stress, Mechanical; D014732:Vibration