Effect of Choto-san, a Kampo medicine, on impairment of passive avoidance performance in senescence accelerated mouse (SAM).
Effect of Choto-san (TJ-47), a Kampo medicine, on impairment of learning performance was evaluated by means of a step-through passive avoidance task in SAMP8 mice, a senescence-prone substrain. Tokishakuyaku-san (TJ-23), another Kampo medicine, was also employed for comparison. SAMP8 mice at the age of 10-12 months showed a poorer passive avoidance response than SAMR1 mice, a senescence-resistant substrain, in the memory-retention test, but not in the memory-acquisition test. Improved response in the memory-retention test was observed in SAMP8 mice treated with TJ-47, and almost equal degree of improvement was also observed after treatment with TJ-23. These results suggest that a long-term administration of Choto-san could improve to some extent the impairment of memory caused by aging.
Department of Geriatrics, Hirosaki University School of Medicine, Hirosaki, Japan.
Yutaka
Y
Mizushima
Shin
S
Kan
Satoshi
S
Yoshida
Yoshifumi
Y
Irie
Yukitomo
Y
Urata
D000375:Aging / Q000187:drug effects*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D008297:Male; D020835:Medicine, Kampo; D008569:Memory Disorders / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy
D004365:Drugs, Chinese Herbal; C120250:choto-san; C413220:toki-shakuyaku-san