Genome function and nuclear architecture: from gene expression to nanoscience.
Biophysical, chemical, and nanoscience approaches to the study of nuclear structure and activity have been developing recently and hold considerable promise. A selection of fundamental problems in genome organization and function are reviewed and discussed in the context of these new perspectives and approaches. Advancing these concepts will require coordinated networks of physicists, chemists, and materials scientists collaborating with cell, developmental, and genome biologists.
The Jackson Laboratory, Bar Harbor, Maine 04609, USA. tpo@jax.org
Timothy P
TP
O'Brien
Carol J
CJ
Bult
Christoph
C
Cremer
Michael
M
Grunze
Barbara B
BB
Knowles
Jorg
J
Langowski
James
J
McNally
Thoru
T
Pederson
Joan C
JC
Politz
Ana
A
Pombo
Gunter
G
Schmahl
Joachim P
JP
Spatz
Roel
R
van Driel
D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D019295:Computational Biology; D005786:Gene Expression Regulation / Q000502:physiology*; D016678:Genome; D006801:Humans; D036103:Nanotechnology / Q000379:methods*