Metabolic networks of microbial systems.
In contrast to bioreactors the metabolites within the microbial cells are converted in an impure atmosphere, yet the productivity seems to be well regulated and not affected by changes in operation variables. These features are attributed to integral metabolic network within the microorganism. With the advent of neo-integrative proteomic approaches the understanding of integration of metabolic and protein-protein interaction networks have began. In this article we review the methods employed to determine the protein-protein interaction and their integration to define metabolite networks. We further present a review of current understanding of network properties, and benefit of studying the networks. The predictions using network structure, for example, in silico experiments help illustrate the importance of studying the network properties. The cells are regarded as complex system but their elements unlike complex systems interact selectively and nonlinearly to produce coherent rather than complex behaviors.
Dept, of Ophthalmic Research, Cleveland Clinic Foundation, Area I 31, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA. bhattas@ccf.org
Sumana
S
Bhattacharya
Subhra
S
Chakrabarti
Amiya
A
Nayak
Sanjoy K
SK
Bhattacharya