Chimeric nucleases stimulate gene targeting in human cells.
Porteus
Matthew H
MH
Department of Biology, California Institute of Technology, Pasadena CA 91125, USA. matthew.porteus@UTSouthwestern.edu
Baltimore
David
D
D002460:Cell Line; D004247:DNA / Q000378:metabolism; D015252:Deoxyribonucleases, Type II Site-Specific / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D019281:Dimerization; D018390:Gene Targeting / Q000379:methods*; D049452:Green Fluorescent Proteins; D006801:Humans; D008164:Luminescent Proteins / Q000235:genetics; D009154:Mutation; D019913:Nuclear Localization Signals; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism*; D011995:Recombination, Genetic; D029701:Saccharomyces cerevisiae Proteins; D014162:Transfection; D016335:Zinc Fingers
D008164:Luminescent Proteins; D019913:Nuclear Localization Signals; D011993:Recombinant Fusion Proteins; D029701:Saccharomyces cerevisiae Proteins; D049452:Green Fluorescent Proteins; D004247:DNA; C037725:SCEI protein, S cerevisiae; C035042:endodeoxyribonuclease FokI; D015252:Deoxyribonucleases, Type II Site-Specific