Antimycobacterial flavones from Haplopappus sonorensis.
Crude extracts of Haplopappus sonorensis (A. Gray) S.F. Blake (Asteraceae), showed activity against Mycobacterium tuberculosis H(37)Rv. By assay-guided fractionation, 5-hydroxy-3,7,4'-trimethoxyflavone (1). 5,7-dihydroxy-3,4'-dimethoxyflavone (2). and 5,4'-dihydroxy-3,7-dimethoxyflavone (3). were identified as the antimycobacterial principles. Compound 2 was the most active compound.
Murillo
J I
JI
Universidad Autónoma de Baja California Sur, Departamento de Agronoma, A P 19-B, La Paz, BCS 23080, Mexico.
Encarnación-Dimayuga
R
R
Malmstrøm
J
J
Christophersen
C
C
Franzblau
S G
SG
D000995:Antitubercular Agents / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D031206:Haplopappus; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000995:Antitubercular Agents; D005419:Flavonoids; D010936:Plant Extracts