Rates of adverse reactions to first and second doses of BCG vaccination: results of a large community trial in Brazilian schoolchildren.
OBJECTIVE
To evaluate the incidence of adverse reactions to first and second bacille Calmette-Guérin (BCG) vaccination in schoolchildren.


METHODS
Enhanced surveillance in a Brazilian trial. Suspected reactions were reported to a nurse who visited cases and completed a standard form.


RESULTS
Among 71341 schoolchildren studied, 33 reactions were reported. Of these, 25 fulfilled the criteria, resulting in a rate of one per 2854 vaccinations, with no deaths or BCG-osis. Reactions to second doses were more common than to first BCG vaccinations, but this difference was not statistically significant.


CONCLUSIONS
Adverse reactions to a second dose of BCG may be more frequent than reactions to a first dose, but they are still rare events.
Instituto de Saúde Coletiva/Universidade Federal da Bahia, Salvador, Bahia. maines@ufba.br
I
I
Dourado
M H
MH
Rios
S M M
SM
Pereira
S S
SS
Cunha
M Y
MY
Ichihara
J C L
JC
Goes
L C
LC
Rodrigues
A L
AL
Bierrenbach
M L
ML
Barreto
D000293:Adolescent; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D001938:Brazil / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D004890:Erythema / Q000139:chemically induced / Q000453:epidemiology; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced / Q000453:epidemiology; D007115:Immunization Schedule; D008199:Lymphadenitis / Q000139:chemically induced / Q000453:epidemiology; D008297:Male; D032541:Mass Vaccination / Q000009:adverse effects*; D015995:Prevalence; D011379:Prognosis; D012042:Registries; D018570:Risk Assessment; D012883:Skin Ulcer / Q000139:chemically induced / Q000453:epidemiology; D013334:Students; D014397:Tuberculosis, Pulmonary / Q000517:prevention & control*
D001500:BCG Vaccine