Complete regression of bone metastases on super bone scan, by low-dose cisplatin, UFT, diethylstilbestrol diphosphate, and dexamethasone in a patient with hormone-refractory prostate cancer.
Many types of chemotherapy are now being attempted all over the world for hormone-refractory prostate cancer (HRPC) patients, and prostate-specific antigen (PSA) reduction in almost half of the treated patients has been reported. However, only a few studies have reported the response of bone metastasis. The authors report a patient with HRPC who obtained complete regression of bone metastases on super bone scan by biochemical modulation (BM), dexamethasone, and endocrine therapy.
Department of Urology, Yamagata Prefectural Hospital, 1800 Aoyagi, Yamagata 990-2292, Japan. hoshi@uro.med.tohoku.ac.jp
Senji
S
Hoshi
Chikara
C
Ohyama
Shigeru
S
Hagisawa
Kunio
K
Ono
Makoto
M
Satoh
Seiichi
S
Saito
Atushi
A
Fukuzaki
Yoichi
Y
Arai
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D019008:Drug Resistance, Neoplasm; D005500:Follow-Up Studies; D006728:Hormones; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D011877:Radionuclide Imaging; D018570:Risk Assessment; D005641:Tegafur / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014498:Uracil / Q000008:administration & dosage
D018931:Antineoplastic Agents, Hormonal; D006728:Hormones; D005641:Tegafur; D014498:Uracil; D004054:Diethylstilbestrol; D003907:Dexamethasone; C004955:fosfestrol; D017430:Prostate-Specific Antigen; D002945:Cisplatin