Plant cell factories and mucosal vaccines.
Many advances continue to be made in the field of plant-derived vaccines. Plants have been shown capable of expressing a multicomponent vaccine that when orally delivered induces a T-helper cell subset 1 response and enables passive immunization. Furthermore, a plant-derived vaccine has been shown to protect against challenge in the target host. Increased antigen expression levels (up to 4.1% total soluble protein) have been obtained through transformation of the chloroplast genome. In view of these findings, plant-derived vaccines have been proved as valuable commodities to the world's health system; however, before their application, studies need to focus on optimization of immunization strategies and to investigate antigen stability.
Walmsley
Amanda M
AM
Department of Plant Biology, Arizona State University, Tempe AZ 85287, USA. amanda.walmsley@asu.edu
Arntzen
Charles J
CJ
D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines; D004355:Drug Stability; D018506:Gene Expression Regulation, Plant; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology; D030821:Plants, Genetically Modified / Q000235:genetics* / Q000276:immunology / Q000821:virology*; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D014170:Transformation, Genetic; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000096:biosynthesis* / Q000235:genetics*; D014765:Viral Vaccines
D001428:Bacterial Vaccines; D011993:Recombinant Fusion Proteins; D014614:Vaccines, Synthetic; D014765:Viral Vaccines