An efficient synthesis of new fluorinated uracil derivatives.
A series of potentially biologically active fluorinated uracil derivatives has been prepared in three steps from oxazolines and fluorinated nitriles with good chemical yields.
Fustero
Santos
S
Departamento de Química Orgánica, Universidad de Valencia, E-46100 Burjassot, Spain. Santos.Fustero@uv.es
Salavert
Esther
E
Sanz-Cervera
Juan F
JF
Piera
Julio
J
Asensio
Amparo
A
D000963:Antimetabolites / Q000138:chemical synthesis; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D010080:Oxazoles / Q000737:chemistry; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D000963:Antimetabolites; D006845:Hydrocarbons, Fluorinated; D009570:Nitriles; D010080:Oxazoles; D014498:Uracil