Hybrid antibiotics.
Hybrid antibiotics that do not occur in nature have been obtained by combining structural genes of antibiotic producers. Some of these substances were effective against pathogenic microorganisms resistant against antibiotics produced by the parent strains. The majority of hybrid antibiotics were obtained by combining genes encoding polyketide synthases. Hybrid peptides with new biological properties have also been synthesized.
Institute of Microbiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czechia. behal@biomed.cas.cz
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D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001419:Bacteria / Q000201:enzymology / Q000235:genetics; D005798:Genes, Bacterial; D005818:Genetic Engineering / Q000379:methods*; D009097:Multienzyme Complexes / Q000235:genetics* / Q000378:metabolism; D011995:Recombination, Genetic
D000900:Anti-Bacterial Agents; D009097:Multienzyme Complexes