Separation of cocaine stereoisomers by capillary electrophoresis using sulfated cyclodextrins.
A capillary electrophoretic method for the separation of cocaine and its stereoisomers was developed. In this study, the effect of organic modifier was also investigated. The separation was achieved using 1% sulfated cyclodextrin, 10 mmol L(-1) phosphate buffer, 10% methanol at pH 3. The method provides good reproducibility and easy application.
Cabovska
B
B
Department of Chemistry, University of Cincinnati, P.O. Box 210172, OH 45221-0172, USA.
Norman
A B
AB
Stalcup
A M
AM
D003042:Cocaine / Q000737:chemistry* / Q000302:isolation & purification*; D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D015394:Molecular Structure; D015203:Reproducibility of Results; D013237:Stereoisomerism; D013431:Sulfates / Q000737:chemistry*
D003505:Cyclodextrins; D013431:Sulfates; D003042:Cocaine