Hypodysfibrinogenemia during pregnancy, labor, and delivery.
BACKGROUND
Hypodysfibrinogenemia is an autosomally dominant disorder that can result in excessive bleeding as well as specific pregnancy complications. Increased risks of spontaneous abortion, postpartum hemorrhage, poor wound healing, and placental abruption have been reported.


METHODS
A woman with hypodysfibrinogenemia presented for care in the first trimester. Her antepartum course was uncomplicated, and she was administered intermediate-purity factor VIII during labor and did not have excessive bleeding postpartum. The infant's cord fibrinogen was low, at 43 mg/dL (normal 215 +/- 30), showing it was similarly affected.


CONCLUSIONS
Pregnancy in patients with hypodysfibrinogenemia can be associated with various complications; however, coordination of care and anticipation of specific problems can result in a successful outcome for both mother and infant.
Department of Obstetrics and Gynecology, Georgetown University Hospital, Washington, DC 20007, USA. deering95@hotmail.com
Shad H
SH
Deering
Helain J
HJ
Landy
Nana
N
Tchabo
Craig
C
Kessler
D000328:Adult; D000347:Afibrinogenemia / Q000175:diagnosis / Q000628:therapy; D001778:Blood Coagulation Disorders / Q000175:diagnosis* / Q000628:therapy; D005169:Factor VIII / Q000008:administration & dosage; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D015241:Fibrinogens, Abnormal / Q000378:metabolism*; D006801:Humans; D007743:Labor, Obstetric; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis* / Q000628:therapy; D011256:Pregnancy Outcome
D015241:Fibrinogens, Abnormal; D005169:Factor VIII; D005340:Fibrinogen