[Study on antagonistic effects of selenium and zinc on the renal impairments induced by fluoride in rats].
Wistar rats were provided with distilled water containing NaF(100 mg/L), and were administered through gavage with Na2SeO3[0.1 mg/(kgBW.d)] and/or ZnSO4[14.8 mg/(kg BW.d)]. The results of biochemical, pathological and ultrastructural examinations showed that fluoride could cause serious renal impairments. The major damage induced by fluoride was epithelia of proximal renal tubules. The lipid peroxidation might be one of the mechanisms of fluoride toxicity. Na2SeO3 and ZnSO4 could antagonize the renal impairments induced by fluoride through their antioxidation. The cooperative effect of Na2SeO3 and ZnSO4 was more powerful than either Na2SeO3 or ZnSO4 alone.
Department of Environmental Health, Tongji Medical University, Wuhan 430030, China.
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Chen
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D000818:Animals; D004357:Drug Synergism; D005260:Female; D005458:Fluoride Poisoning / Q000378:metabolism; D007674:Kidney Diseases / Q000139:chemically induced*; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*; D012969:Sodium Fluoride / Q000037:antagonists & inhibitors*; D015032:Zinc / Q000494:pharmacology*
D008054:Lipid Peroxides; D012969:Sodium Fluoride; D012643:Selenium; D015032:Zinc