Movement Disorders Society Scientific Issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders.
As there are no biological markers for the antemortem diagnosis of degenerative parkinsonian disorders, diagnosis currently relies upon the presence and progression of clinical features and confirmation depends on neuropathology. Clinicopathologic studies have shown significant false-positive and false-negative rates for diagnosing these disorders, and misdiagnosis is especially common during the early stages of these diseases. It is important to establish a set of widely accepted diagnostic criteria for these disorders that may be applied and reproduced in a blinded fashion. This review summarizes the findings of the SIC Task Force for the study of diagnostic criteria for parkinsonian disorders in the areas of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy, multiple system atrophy, and corticobasal degeneration. In each of these areas, diagnosis continues to rest on clinical findings and the judicious use of ancillary studies.
Movement Disorder Program, University of Louisville, KY 40205, USA. i.litvan@louisville.edu
Irene
I
Litvan
Kailash P
KP
Bhatia
David J
DJ
Burn
Christopher G
CG
Goetz
Anthony E
AE
Lang
Ian
I
McKeith
Niall
N
Quinn
Kapil D
KD
Sethi
Cliff
C
Shults
Gregor K
GK
Wenning
D015415:Biomarkers; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control; D003943:Diagnostic Techniques, Neurological / Q000592:standards*; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis; D019578:Multiple System Atrophy / Q000175:diagnosis; D020734:Parkinsonian Disorders / Q000175:diagnosis*; D015203:Reproducibility of Results; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis
D015415:Biomarkers