Excretion of wild-type and vaccine-derived poliovirus in the feces of poliovirus receptor-transgenic mice.
The emergence of circulating vaccine-derived poliovirus (cVDPV) strains in suboptimally vaccinated populations is a serious threat to the global poliovirus eradication. The genetic determinants for the transmissibility phenotype of polioviruses, and in particularly of cVDPV strains, are currently unknown. Here we describe the fecal excretion of wild-type poliovirus, oral polio vaccine, and cVDPV (Hispaniola) strains after intraperitoneal injection in poliovirus receptor-transgenic mice. Both the pattern and the level of fecal excretion of the cVDPV strains resemble those of wild-type poliovirus type 1. In contrast, very little poliovirus was present in the feces after oral polio vaccine administration. This mouse model will be helpful in elucidating the genetic determinants for the high fecal-oral transmission phenotype of cVDPV strains.
Boot
Hein J
HJ
Laboratory for Vaccine-Preventable Diseases, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Hein.Boot@RIVM.NL
Kasteel
Daniella T J
DT
Buisman
Anne-Marie
AM
Kimman
Tjeerd G
TG
D000818:Animals; D005243:Feces / Q000821:virology*; D006801:Humans; D008565:Membrane Proteins; D051379:Mice; D008822:Mice, Transgenic; D011051:Poliomyelitis / Q000517:prevention & control; D017955:Poliovirus / Q000145:classification / Q000302:isolation & purification* / Q000472:pathogenicity; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage; D011991:Receptors, Virus / Q000235:genetics*; D012703:Serotyping; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000008:administration & dosage; D017201:Virus Shedding
D008565:Membrane Proteins; D011055:Poliovirus Vaccine, Oral; D011991:Receptors, Virus; D015164:Vaccines, Inactivated; C066100:poliovirus receptor