[ACE gene polymorphism and renal scarring in children with urinary tract infection and vesicoureteric reflux: preliminary results].
To investigate angiotensin-converting enzyme (ACE) gene deletion/insertion (D/I) polymorphism as a risk factor of renal scarring in children, we determined ACE genotypes in 63 paediatric patients with primary vesicoureteric reflux (VUR) grade I-V and recurrent urinary tract infections (UTI). Renal cortical scars were evaluated applying Technetium-99-m-unithiol SPECT method in 21 children. No statistically significant differences were found in allele and genotype distribution of the D/I polymorphism within ACE gene between children with VUR/UTI and healthy Caucasians (n = 806, after meta-analysis of literature data) (D allele frequencies--47% vs 54%, respectively). It suggests that ACE gene polymorphism is not associated with primary VUR. Renal scarring was revealed in 7 out of 21 children and there was also no statistically significant difference in D/I distribution between scar (n = 7) and non-scar (n = 14) subgroups of patients and controls. However, higher incidence of D allele (64%) in children with renal parenchymal damage could suggest the hypothesis that this genetic factor plays an important role in renal scarring. Therefore, to verify this assumption further studies on a larger group of patients are needed.
Kowalewska-Pietrzak
Magdalena
M
Klinika Chorób Dzieci Instytutu Pediatrii Uniwersytetu Medycznego w Łodzi. jarekmagda@interia.pl
Młynarski
Wojciech
W
Młodkowska
Ewa
E
Kozłowski
Janusz
J
Kubryn
Izabela
I
Gadzicki
Mariusz
M
Bodalski
Jerzy
J
D002648:Child; D002921:Cicatrix / Q000000981:diagnostic imaging* / Q000209:etiology*; D004252:DNA Mutational Analysis; D005260:Female; D005500:Follow-Up Studies; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D017354:Point Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D015899:Tomography, Emission-Computed, Single-Photon; D014552:Urinary Tract Infections / Q000150:complications*; D014718:Vesico-Ureteral Reflux / Q000150:complications*
D007703:Peptidyl-Dipeptidase A