Plasma orexin-A-like immunoreactivity in patients with sleep apnea hypopnea syndrome.
Orexin-A (hypocretin-1), a neuropeptide produced in hypothalamus, stimulates arousal. We studied plasma concentrations of orexin-A-like immunoreactivity (orexin-A-LI) in 156 patients with sleep apnea hypopnea syndrome (SAHS) and 22 control subjects. Plasma orexin-A-LI levels were significantly decreased in 156 patients with SAHS (4.4+/-0.15 pmol/l, mean+/-S.E.) as compared with controls (5.3+/-0.45 pmol/l). The levels were decreased in parallel with the severity of sleep-related respiratory disturbance and magnitude of sleep fragmentation. These findings raise the possibility that a low plasma level of orexin-A-LI may be a marker to show the severity of the disease in patients with SAHS.
Third Department of Internal Medicine, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka 020-8505, Japan. tsuguo@ck-.so-net.ne.jp
Tsuguo
T
Nishijima
Shigeru
S
Sakurai
Zenei
Z
Arihara
Kazuhiro
K
Takahashi
D001143:Arousal / Q000502:physiology; D002352:Carrier Proteins / Q000097:blood* / Q000276:immunology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D009479:Neuropeptides / Q000097:blood* / Q000276:immunology; D018377:Neurotransmitter Agents / Q000097:blood* / Q000276:immunology; D000068797:Orexins; D017286:Polysomnography; D012891:Sleep Apnea Syndromes / Q000097:blood* / Q000503:physiopathology
D002352:Carrier Proteins; C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D000068797:Orexins