Broad-spectrum radical cyclizations boosted by polarity matching. Carbonylative access to alpha-stannylmethylene lactams from azaenynes and CO.
Free-radical mediated stannylcarbonylation of azaenynes provides a general [n + 1]-type annulation approach leading to alpha-stannylmethylene lactams. The cyclization is unusual in its breadth, covering 4-exo, 5-exo, 6-exo, 7-exo, and 8-exo modes.
Ryu
Ilhyong
I
Department of Chemistry, Faculty of Arts and Sciences, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan. ryu@ms.cias.osakafu-u.ac.jp
Miyazato
Hironari
H
Kuriyama
Hiroki
H
Matsu
Kazutoshi
K
Tojino
Mami
M
Fukuyama
Takahide
T
Minakata
Satoshi
S
Komatsu
Mitsuo
M