Mitochondrial regulation of apoptosis.
Mitochondria play a central part in cellular survival and apoptotic death. These processes are highly regulated by pro- and antiapoptotic Bcl-2 superfamily members. A key feature within apoptosis cascades is disruption of mitochondrial transmembrane potential and apoptogenic protein release, caused by opening of the permeability transition pore (PT). New data, however, indicate that mitochondrial apoptosis may occur without PT involvement.
Emergentec Analytics and Internal Medicine III, Department of Nephrology, University of Vienna, A-1090 Vienna, Austria.
Bernd
B
Mayer
Rainer
R
Oberbauer
D017209:Apoptosis / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D008954:Models, Biological