Derivation of lung epithelium from bone marrow cells.
Recent studies demonstrate the capacity of BM-derived cells to engraft as differentiated cells of a variety of organs, including lung. In this paper, we review the current state-of-the-art in this area. We also summarize our work demonstrating that cultured adherent marrow cells can serve as progenitors of lung alveolar epithelium.
The Pulmonary Center, Boston University School of Medicine, MA 02118, USA.
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DN
Kotton
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Fine
D000818:Animals; D051402:Aquaporin 5; D020346:Aquaporins / Q000378:metabolism; D015415:Biomarkers; D001854:Bone Marrow Cells / Q000166:cytology / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D048429:Cell Size / Q000502:physiology; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000378:metabolism; D051542:Hepatocyte Nuclear Factor 3-beta; D008168:Lung / Q000166:cytology / Q000196:embryology* / Q000502:physiology*; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D009687:Nuclear Proteins / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D020545:Respiratory Mucosa / Q000166:cytology / Q000196:embryology* / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000378:metabolism; D014598:Uteroglobin; D000098853:Podoplanin
D051402:Aquaporin 5; D020346:Aquaporins; D015415:Biomarkers; D004268:DNA-Binding Proteins; D051542:Hepatocyte Nuclear Factor 3-beta; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D011506:Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D014598:Uteroglobin; C496038:Aqp5 protein, mouse; C496503:Foxa2 protein, mouse; C490441:Pdpn protein, mouse; D000098853:Podoplanin; C556390:Scgb1a1 protein, mouse