Daphniglaucins A and B, novel polycyclic quaternary alkaloids from Daphniphyllum glaucescens.
[structure: see text] Two cytotoxic quaternary Daphniphyllum alkaloids with an unprecedented fused-polycyclic skeleton containing a 1-azoniatetracyclo[5.2.2.0.(1,6)0.(4,9)]undecane ring system, daphniglaucins A (1) and B (2), have been isolated from the leaves of Daphniphyllum glaucescens. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic data.
Kobayashi
Jun'ichi
J
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. jkobay@pharm.hokudai.ac.jp
Takatsu
Hiroshi
H
Shen
Ya-Ching
YC
Morita
Hiroshi
H
D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000302:isolation & purification*; D007564:Japan; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000302:isolation & purification*; D016339:Spectrometry, Mass, Fast Atom Bombardment
D001952:Bridged-Ring Compounds; D010936:Plant Extracts; D011083:Polycyclic Compounds; C476519:daphniglaucin A; C476520:daphniglaucin B