Synthesis, characterization, and antibacterial activities of some rare Earth metal complexes of pipemidic acid.
Eight new solid complexes of pipemidic acid (PPA) with trichlorizated rare earth metals LaCl(3), CeCl(3), PrCl(3), NdCl(3), SmCl(3), TbCl(3), DyCl(3), and YCl(3) have been synthesized. The complexes were characterized by elemental analyses, IR, NMR, and molar conductance measurements. The general formulas of the complexes are [M(PPA)(4)]Cl(3) (M=Ce(III), Pr(III), Nd(III), Sm(III), Tb(III), Dy(III), Y(III)), and [La(PPA)(4)Cl]Cl(2). At the same time, the antibacterial activities of PPA and four of its complexes were tested. The results show that PPA and its complexes all have inhibitory action against bacteria of Escherichia coli, Bacillus subtilis, Streptococcus pneumoniae, and Pseudomonas aeruginosa but not Staphylococcus aureus. We compared their antibacterial activities and found that the antibacterial activity of [La(PPA)(4)Cl]Cl(2) against S. pneumoniae is much stronger than that of PPA and the other complexes.
Yang
Lin
L
College of Chemistry and Environmental Science, Henan Normal University, Xinxiang, China. yx119972@sohu.com
Tao
Dongliang
D
Yang
Xiaoli
X
Li
Yongfang
Y
Guo
Yuming
Y
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008674:Metals, Rare Earth / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D010876:Pipemidic Acid / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D000890:Anti-Infective Agents; D008674:Metals, Rare Earth; D010876:Pipemidic Acid