GC-MS analysis and bioactivity testing of the volatile oil from the leaves of the toothbrush tree Salvadora persica L.
Upon GC-MS analysis of the volatile oil extracted from Salvadora persica L. leaves, we were able to identify benzyl nitrile, eugenol, thymol, isothymol, eucalyptol, isoterpinolene, and beta-caryophyllene. Toxicity of the aroma was evaluated using brine shrimp lethality test which gave an LC50 > 1,000 ppm. Using Disc Diffusion Test, it was found that the extract of the leaves has a considerable antibacterial effect on several different oral aerobic bacteria with comparable results to known antibiotics. The extract can be used effectively as a natural tool for teeth cleaning and as a natural analgesic for the disturbing toothache.
Faculty of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, Jordan University of Science and Technology, P.O. Box 3030, Irbid, Jordan. Falali@just.edu.jo
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Alali
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Al-Lafi
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001156:Artemia; D001420:Bacteria, Aerobic / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D032121:Salvadoraceae / Q000737:chemistry*; D014098:Toothache / Q000188:drug therapy
D000700:Analgesics; D009822:Oils, Volatile; D010936:Plant Extracts