Gastrointestinal effects of Mebarid, an ayurvedic formulation, in experimental animals.
Mebarid, an ayurvedic formulation, was tested for its anti-diarrhoeal, anti-ulcer and anti-motility activities in animals. Mebarid was investigated at four dose levels of 125, 250, 500 mg/kg BW and 1g/kg BW The methods of castor oil-induced diarrhoea and pylorus-ligation-induced ulcers in rats were used to evaluate the anti-diarrhoeal and anti-ulcer activity, respectively, while charcoal meal test in mice was the method used for testing its anti-motility effect. Mebarid was found to have significant activity in all the three models. Thus, it can be concluded that Mebarid possesses anti-diarrhoeal, anti-motility and anti-ulcer activities and can prove beneficial in the treatment of above gastrointestinal disorders.
Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune 411 038, India.
Pallavi
P
Bafna
Subhash
S
Bodhankar
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D000930:Antidiarrheals / Q000008:administration & dosage / Q000627:therapeutic use*; D003967:Diarrhea / Q000209:etiology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D010437:Peptic Ulcer / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar
D000897:Anti-Ulcer Agents; D000930:Antidiarrheals