Survivin expression in the stomach: implications for mucosal integrity and protection.
Survivin, an apoptosis inhibitor, is highly expressed in a majority of human cancers and is required during embryonic development. Our present studies show that survivin is also expressed in normal gastric mucosa of adult humans and rats. In both human and rat gastric mucosa, survivin is expressed predominantly in the nuclei of mucosal surface epithelial cells. In rats, survivin is also detected in the nuclei of some neck cells, whereas in the humans, survivin is expressed in both nuclei and cytoplasm of chief and parietal cells. Furthermore, survivin is expressed at higher levels in the nuclei of cultured gastric mucosal epithelial cells than in gastric microvascular endothelial cells, which supports the expression pattern in intact tissues. Based on these expression studies, and the known role of survivin as an anti-apoptosis protein, survivin may play a role in maintaining gastric mucosal integrity and regulating cell renewal in the gastric mucosa.
Department of Medicine, Veterans Affairs Medical Center, Long Beach, 5901 East Seventh Street, Long Beach, CA 90822, USA.
Shiun-Kwei
SK
Chiou
Woo Sung
WS
Moon
Michael K
MK
Jones
Andrzej S
AS
Tarnawski
D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry; D002478:Cells, Cultured; D019610:Cytoprotection; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D009363:Neoplasm Proteins; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D000077022:Survivin; D014158:Transcription, Genetic
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D000077022:Survivin