Biopterin metabolism in patients with malignant syndrome.
We examined the autopsied brains of two parkinsonian patients who had malignant syndrome (MS). Neopterin and biopterin contents, and GTP cyclohydrolase I activity were measured in various region of the brain. We found relatively higher GTP cyclohydrolase I activities in the hypothalamus compared with other regions of the brain from patients with MS. This finding suggested a possible involvement of biopterin metabolism in pathophysiology of MS. This is the first report on biopterin metabolism in the brains of patients with MS.
Ichinose
Hiroshi
H
Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Ohye
Tamae
T
Shinotoh
Hitoshi
H
Arai
Kimihito
K
Yamazaki
Shunzo
S
Mizuta
Eiji
E
Kuno
Sadako
S
Nagatsu
Toshiharu
T
D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000009:adverse effects; D001708:Biopterins / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005260:Female; D006136:GTP Cyclohydrolase / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000378:metabolism; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology / Q000378:metabolism*; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism*; D013375:Substance Withdrawal Syndrome / Q000378:metabolism
D000978:Antiparkinson Agents; D001708:Biopterins; D019798:Neopterin; D006136:GTP Cyclohydrolase