Genome function and nuclear architecture: from gene expression to nanoscience.
Biophysical, chemical, and nanoscience approaches to the study of nuclear structure and activity have been developing recently and hold considerable promise. A selection of fundamental problems in genome organization and function are reviewed and discussed in the context of these new perspectives and approaches. Advancing these concepts will require coordinated networks of physicists, chemists, and materials scientists collaborating with cell, developmental, and genome biologists.
O'Brien
Timothy P
TP
The Jackson Laboratory, Bar Harbor, Maine 04609, USA. tpo@jax.org
Bult
Carol J
CJ
Cremer
Christoph
C
Grunze
Michael
M
Knowles
Barbara B
BB
Langowski
Jorg
J
McNally
James
J
Pederson
Thoru
T
Politz
Joan C
JC
Pombo
Ana
A
Schmahl
Gunter
G
Spatz
Joachim P
JP
van Driel
Roel
R
D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D019295:Computational Biology; D005786:Gene Expression Regulation / Q000502:physiology*; D016678:Genome; D006801:Humans; D036103:Nanotechnology / Q000379:methods*