Lipoxins and aspirin-triggered lipoxins in airway responses.
Here, we have demonstrated potent inhibition of allergen-mediated pulmonary inflammation and airway hyper-responsiveness by a novel dual-pronged action of LX's. Moreover, these results indicate that LX's play pivotal and previously unappreciated roles in regulating allergy and pulmonary inflammation.
Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Bruce D
BD
Levy
George T
GT
De Sanctis
Pallavi R
PR
Devchand
Eugene
E
Kim
Kate
K
Ackerman
Birgitta
B
Schmidt
Wojciech
W
Szczeklik
Jeffrey M
JM
Drazen
Charles N
CN
Serhan
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology*; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D007962:Leukocytes / Q000378:metabolism; D044045:Lipoxins; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D044042:Receptors, Formyl Peptide; D044067:Receptors, Lipoxin
C105101:FPR2 protein, human; D006893:Hydroxyeicosatetraenoic Acids; D044045:Lipoxins; D011956:Receptors, Cell Surface; D044042:Receptors, Formyl Peptide; D044067:Receptors, Lipoxin; C040527:lipoxin A4; D001241:Aspirin