[Study on the regulative effect of isomaltooligosaccharides on human intestinal flora].
OBJECTIVE
In order to study the effect of Isomaltooligosaccharides on Human and mouse intestinal flora in vivo.


METHODS
1. 30 health subjects (15 male, 15 female) were randomly selected from the clinic of Tianjin CDC. They were provide 15 g Isomaltooligosaccharides once a day for 7 days; 2. 40 BABL/c mice were divided into 4 groups, 3 experimental groups and 1 control group. These 3 experimental groups were fed different dose of Isomaltooligosaccharides by gavage for 7 days. Feces of both human and mice were determined before and at the end of the experiment.


RESULTS
The results showed that the reproduction of Bifidobacteria and Lactobacillus greatly increased, and the growth of Clostridium perfriengenes was significantly inhibited both in mice and human intestinal tracts.


CONCLUSIONS
Isomaltooligosaccharides could regulate and improve the intestinal flora in both mice and human intestine.
Tianjin Centers for Disease Control and Provention, Tianjin 300011, China.
Qing
Q
Gu
Yi
Y
Yang
Guohong
G
Jiang
Gai
G
Chang
D000328:Adult; D000818:Animals; D001644:Bifidobacterium / Q000254:growth & development*; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D007527:Isoenzymes / Q000494:pharmacology; D007778:Lactobacillus / Q000254:growth & development*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D009844:Oligosaccharides / Q000494:pharmacology*; D011897:Random Allocation
D007527:Isoenzymes; D009844:Oligosaccharides; C021705:maltooligosaccharides