Targeted drug aerosol deposition analysis for a four-generation lung airway model with hemispherical tumors.
One important research area of broad interest is the development of highly efficient drug delivery systems for desired site deposition and uptake. For example, controlled drug aerosol release and targeting to specific regions of the lung is a novel way to combat lung diseases, diabetes, virus infections, cancers, etc. Determination of feasible air-particle streams is a prerequisite for the development of such delivery devices, say, smart inhalers. The concept of "controlled particle release and targeting" is introduced and results are discussed for a representative model of bronchial lung airways afflicted with hemispherical tumors of different sizes and locations. It is shown that under normal particle inlet conditions a particle mass fraction of only up to 11% may deposit on the surface of a specific tumor with critical radius r/R approximately 1.25, while a controlled particle release achieves deposition fractions of 35 to 92% for a realistic combination of inlet Stokes and Reynolds numbers, depending mainly on tumor size. Furthermore, with the controlled release and targeting approach nearby healthy tissue is hardly impacted by the typically aggressive drug aerosols. Assuming laminar, quasi-steady, three-dimensional air flow and spherical non-interacting micron-particles in sequentially bifurcating rigid airways, the results were obtained using a validated commercial finite-volume code with user-enhanced programs on a high-end engineering workstation. The new concept is generic and hence should be applicable to other regions of the respiratory system as well.
Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910, USA. ck@eos.ncsu.edu
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Zhang
D000280:Administration, Inhalation; D000327:Adsorption; D000336:Aerosols / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D001984:Bronchial Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D003198:Computer Simulation; D016503:Drug Delivery Systems / Q000379:methods*; D004360:Drug Therapy, Computer-Assisted / Q000379:methods; D020342:Finite Element Analysis; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D008954:Models, Biological; D010316:Particle Size; D011673:Pulsatile Flow; D012212:Rheology / Q000379:methods; D012680:Sensitivity and Specificity
D000336:Aerosols