Trimethylsilyl halide-promoted Michaelis-Arbuzov rearrangement.
[reaction: see text] We describe a new, straightforward, and easy-to-handle method for achieving an unprecedented trimethylsilyl halide-catalyzed Michaelis-Arbuzov-like rearrangement. This rearrangement occurs at temperatures from room temperature to 80 degrees C and does not require addition of any alkyl halide. The scope and limitations of this new reaction are explored, as well as its mechanism.
Service de Marquage Moléculaire et de Chimie Bioorganique, CEA Saclay, F-91191 Gif sur Yvette Cedex, France. pierre-yves.renard@cea.fr
Pierre-Yves
PY
Renard
Philippe
P
Vayron
Charles
C
Mioskowski