[Application of pharmacotherapy with classic neuroleptics: phenothiazine derivatives in schizophrenia].
Tricyclic psychotropic drugs (TDP) are used in the therapy of both schizophrenia and affective disturbances, especially depressive ones. They are a large group of compounds with a broadband spectrum, especially as an antipsychotic and antidepressant drugs. Phenothiazine derivatives distinguish themselves with a structure of triple cycles arrangement, composed of electrons such as a sulphur and nitrogen atoms. Among patients with schizophrenia there are many groups with different psychopathological symptoms, course of disease and neuroleptics drugs response. Affective disturbances occur particularly often in the course of schizophrenia. A higher incidence of depression in the course of schizophrenia has been observed during treatment with neuroleptics, especially in the late phase of treatment, particularly after using strong neuroleptics.
Zakład Chemii Nieorganicznej i Analitycznej Uniwersytetu w Białymstoku.
Ewa
E
Kleszczewska
Jolanta
J
Hejza
D014150:Antipsychotic Agents / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use*; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism; D006801:Humans; D010640:Phenothiazines; D012559:Schizophrenia / Q000188:drug therapy*
D014150:Antipsychotic Agents; D010640:Phenothiazines; D019389:Cytochrome P-450 CYP2D6