The myeloid disorders: background.
Myeloid disorders do not usually present quite so many technical challenges to the cytogeneticist as does ALL: the chromosomes are often of a better quality, and white blood cell counts are not usually so high, except in CGL. Unlike in the chronic lymphoid disorders, there is no need for mitogens to include cell division. However, apart from the Ph in CGL, the overall frequency of detected clones is not so high. This has the consequence that a large proportion of patients is denied the diagnostic and prognostic benefit of knowing the cytogenetic abnormalities that are associated with their disease.
Academic Haematology and Cytogenetics, The Royal Marsden NHS Trust, The Institute of Cancer Research, Surrey, UK.
John
J
Swansbury
D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D003582:Cytogenetics / Q000379:methods; D006801:Humans; D007621:Karyotyping / Q000379:methods*; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000235:genetics*; D009196:Myeloproliferative Disorders / Q000175:diagnosis / Q000235:genetics*; D010677:Philadelphia Chromosome; D011379:Prognosis