Heterocyclic compounds as inflammation inhibitors.
Clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with significant toxicity particularly in the gastrointestinal tract and kidney. Various approaches such as formulation co-administration (of agents to protect the stomach), chemical manipulation and synthesis of new safer anti-inflammatory drugs reported in the literature to overcome the toxicity of NSAIDs have been summarized. As far as synthesis of new more effective and safer anti-inflammatory drugs is concerned, we have reported recent findings in the area of synthesis of heterocyclic compounds such as pyrimidines, imidazole, benzimidazole, thiazole, thiazolidine, acridine, thiourea, alkanoic acid derivatives and other related heterocyclic compounds and their role as inflammation inhibitors.
Sondhi
Sham M
SM
Department of Chemistry, University of Roorkee, Roorkee, 247667, INDIA.
Singhal
Nidhi
N
Johar
Monika
M
Reddy
B S Narayan
BS
Lown
J William
JW
D000166:Acridines / Q000138:chemical synthesis / Q000494:pharmacology; D000473:Alkanes / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006571:Heterocyclic Compounds / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology; D013890:Thiourea / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology
D000166:Acridines; D000473:Alkanes; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001562:Benzimidazoles; D002264:Carboxylic Acids; D006571:Heterocyclic Compounds; D007093:Imidazoles; D011743:Pyrimidines; D013844:Thiazoles; C029899:imidazole; C031000:benzimidazole; D013890:Thiourea