Coordinate regulation of an extended chromosome domain.
Spitz et al (2003[this issue of Cell]) describe the properties of a novel cis-regulatory DNA element, the global control region (GCR), which regulates gene expression over distances of several hundred kilobases at the mouse HoxD complex. The GCR provides an explanation for the colinear genetic linkage and expression of individual Hox genes within developing limbs.
Calhoun
Vincent C
VC
Department of Molecular and Cell Biology, Division of Genetics and Development, University of California-Berkeley, Berkeley, CA 94720, USA.
Levine
Michael
M
D000818:Animals; D033481:Chromosomes, Mammalian / Q000235:genetics*; D004742:Enhancer Elements, Genetic / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D018398:Homeodomain Proteins / Q000235:genetics*; D051379:Mice; D011401:Promoter Regions, Genetic / Q000235:genetics
D018398:Homeodomain Proteins