Hybrid virus-polymer materials. 1. Synthesis and properties of PEG-decorated cowpea mosaic virus.
Cowpea mosaic virus was derivatized with poly(ethylene glycol) to give well-controlled loadings of polymer on the outer surface of the coat protein assembly. The resulting conjugates displayed altered densities and immunogenicities, consistent with the known chemical and biological properties of PEG. These studies make CPMV potentially useful as a tailored vehicle for drug delivery.
Raja
Krishnaswami S
KS
Department of Chemistry, The Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA.
Wang
Qian
Q
Gonzalez
María José
MJ
Manchester
Marianne
M
Johnson
John E
JE
Finn
M G
MG
D000818:Animals; D017798:Comovirus / Q000737:chemistry* / Q000235:genetics; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
D011108:Polymers; D011092:Polyethylene Glycols