Activation of coagulation by administration of recombinant factor VIIa elicits interleukin 6 (IL-6) and IL-8 release in healthy human subjects.
The activation of coagulation has been shown to contribute to proinflammatory responses in animal and in vitro experiments. Here we report that the activation of coagulation in healthy human subjects by the administration of recombinant factor VIIa also elicits a small but significant increase in the concentrations of interleukin 6 (IL-6) and IL-8 in plasma. This increase was absent when the subjects were pretreated with recombinant nematode anticoagulant protein c2, the inhibitor of tissue factor-factor VIIa.
Department of Intensive Care, Academic Medical Center, University of Amsterdam, The Netherlands. e.dejonge@amc.uva.nl
Evert
E
de Jonge
Philip W
PW
Friederich
George P
GP
Vlasuk
William E
WE
Rote
Margaretha B
MB
Vroom
Marcel
M
Levi
Tom
T
van der Poll
D001777:Blood Coagulation / Q000187:drug effects*; D005167:Factor VII / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D015942:Factor VIIa; D015801:Helminth Proteins / Q000494:pharmacology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D007700:Kinetics; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D015801:Helminth Proteins; D015850:Interleukin-6; D016209:Interleukin-8; D011994:Recombinant Proteins; C400226:anti-coagulant protein C2, Ancylostoma caninum; D005167:Factor VII; C103587:recombinant FVIIa; D015942:Factor VIIa