Electrotonic cancellation of transmural electrical gradients in the left ventricle in man.
Myocardial cells isolated from different depths of the ventricular wall show substantial differences in action potential duration. Whether these electrophysiological differences are present in vivo when the cells are well coupled is a subject of ongoing controversy. This article provides a brief review and includes experimental evidence derived from patients undergoing cardiac surgery.
Department of Cardiology and Cardiothoracic Surgery, The Hatter Institute for Cardiovascular Studies, University College Hospital, Grafton Way, WC1 6DB, London, UK. peter.taggart@uclh.org
Peter
P
Taggart
Peter
P
Sutton
Tobias
T
Opthof
Ruben
R
Coronel
Panny
P
Kallis
D000200:Action Potentials; D000818:Animals; D004285:Dogs; D004594:Electrophysiology; D004699:Endocardium / Q000473:pathology; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D009200:Myocardial Contraction; D017202:Myocardial Ischemia; D009206:Myocardium / Q000473:pathology; D010496:Pericardium / Q000502:physiology; D013997:Time Factors; D016276:Ventricular Function; D016277:Ventricular Function, Left