[Thalidomide: new perspectives for its use as antiinflammatory, immunossupressive and antiangiogenic drug].
The new uses of thalidomide are reviewed. It has recently been used as antinflammatory, immunosuppressive, antiangiogenic, and antiviral agent. Although its mechanism of action is not yet understood, the advantage of its use in several diseases, such as erythema nodosum leprosum, multiple myeloma, and graft-versus-host-disease is evident. Owing to its teratogenic properties, the use of thalidomide must be very well controlled. However, thalidomide has become a very important alternative, with new applications being studied.
Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Larissa de Godoy
Lde G
Borges
Pedro Eduardo
PE
Frõehlich
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D019380:Anti-HIV Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004893:Erythema Nodosum / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D009101:Multiple Myeloma / Q000188:drug therapy; D013792:Thalidomide / Q000737:chemistry / Q000627:therapeutic use*
D020533:Angiogenesis Inhibitors; D019380:Anti-HIV Agents; D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D013792:Thalidomide