Aspirin reversal--an incremental administration of aspirin shortens the bleeding time prolonged by low-dose aspirin.
In summary, an incremental dosage of aspirin (660 mg) shortens the bleeding time prolonged by daily low-dosage aspirin (81 mg) in healthy subjects. The "Aspirin Reversal" phenomenon might be useful to control excessive bleeding during surgery in patients taking daily low-dosage aspirin as anti-coagulants.
Yokoyama
Takeshi
T
Department of Anesthesiology and Resuscitology, Kochi Medical School, Nankoku 783-8505.
Yamashita
Koichi
K
Yamasaki
Fumiyasu
F
Ueta
Tadashi
T
Manabe
Masanobu
M
Nishiyama
Tomoki
T
D000328:Adult; D000700:Analgesics / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage* / Q000494:pharmacology; D001760:Bleeding Time; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011517:Prothrombin Time
D000700:Analgesics; D001241:Aspirin