Biochemical markers of bone and cartilage remodeling in prediction of longterm progression of knee osteoarthritis.
OBJECTIVE
To investigate the relationship between biochemical markers of bone and cartilage remodeling and severity or progression (symptoms and structure) of knee osteoarthritis (OA).


METHODS
Mean and minimal joint space width (JSW) of the femorotibial joint were measured from standardized radiographs taken at baseline and at the end of a 3-year longitudinal study of patients with knee OA. Pain, stiffness, and physical function subscales of the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index were assessed at the same time points. Biochemical markers [serum keratan sulfate (KS), serum hyaluronic acid (HA), urine pyridinoline (PYD) and deoxypyridinoline (DPD), serum osteocalcin (OC), cartilage oligomeric matrix protein (COMP)] were assessed at baseline and after 1 year.


RESULTS
At baseline, no significant correlations were observed between values of biochemical markers and JSW or any of the WOMAC scores. Baseline markers were not correlated with 3-year percentage changes observed in mean or minimal JSW and WOMAC scores. Changes observed after 1 year in OC and HA were significantly correlated with 3-year progression in mean JSW (r = -0.24, p = 0.04 and r = 0.27, p = 0.02, respectively) and in minimal JSW (r = -0.31, p = 0.01 and r = 0.24, p = 0.04, respectively). In patients from the lowest quartile of 1-year changes in HA (< -21.22 ng/ml), mean JSW decreased after 3 years by 0.76 (1.23) mm compared to an increase of 0.11 (0.83) mm in patients in the highest quartile (> +14.34 ng/ml) (p = 0.03).


CONCLUSIONS
The 3-year radiological progression of knee OA could be predicted by a 1-year increase in OC or a 1-year decrease in HA levels.
Bruyere
Olivier
O
WHO Collaborating Center for Public Health Aspect of Osteoarticular Disorders (CCPHAOD), Liege, Belgium.
Collette
Julien H
JH
Ethgen
Olivier
O
Rovati
Lucio C
LC
Giacovelli
Giampaolo
G
Henrotin
Yves E
YE
Seidel
Laurence
L
Reginster
Jean-Yves L
JY
D000368:Aged; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology*; D002356:Cartilage / Q000378:metabolism / Q000473:pathology*; D064236:Cartilage Oligomeric Matrix Protein; D018450:Disease Progression; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D007632:Keratan Sulfate / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D064235:Matrilin Proteins; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D015675:Osteocalcin / Q000097:blood; D011237:Predictive Value of Tests; D011859:Radiography
D000596:Amino Acids; D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; C577553:TSP5 protein, human; D015675:Osteocalcin; C015484:pyridinoline; C036020:deoxypyridinoline; D006820:Hyaluronic Acid; D007632:Keratan Sulfate