Leukemoid reaction response to chemotherapy and radiotherapy in a patient with cervical carcinoma.
A white blood cell count more than 50 x 10(9)/l associated with a cause outside the bone marrow is termed a leukemoid reaction. Although it simulates leukemia, most of its causes are benign. Malignancy as a cause of a leukemoid reaction is still a medical dilemma. It is thought to be attributed to granulocyte colony-stimulating factor (G-CSF) secreted by the tumor cells. To our knowledge this is the first time a leukemoid reaction has been reported in association with cervical cancer. We even managed to monitor the leukemoid reaction response to chemotherapy and radiotherapy.
Department of Internal Medicine, Mercy Fitzgerald Hospital, 1500 Lansdowne Ave., Darby, PA 19018, USA.
H S
HS
Nimieri
S N
SN
Makoni
F H
FH
Madziwa
D S
DS
Nemiary
D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects; D014408:Biomarkers, Tumor / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000150:complications / Q000175:diagnosis; D003131:Combined Modality Therapy / Q000009:adverse effects; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007955:Leukemoid Reaction / Q000209:etiology*; D007958:Leukocyte Count; D011878:Radiotherapy / Q000009:adverse effects; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000150:complications / Q000175:diagnosis*
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor