Gender differences in asthma prevalence may depend on how asthma is defined.
BACKGROUND
Asthma may be defined either as wheeze within the previous 12 months (current wheeze) doctor-diagnosed asthma (DDA), or current wheeze plus confirmed airway hyperresponsiveness (AHR).


OBJECTIVE
We wanted to estimate asthma prevalence in randomly selected adolescents based on different criteria for asthma diagnosis, study gender differences in reported asthma-like symptoms vs DDA, and relate our findings to measurements of AHR, levels of exhaled nitric oxide (ENO) and total IgE.


METHODS
As part of the health survey of North-Trøndelag (HUNT), 8571 adolescents aged 13-19 years were investigated with an interview on allergic and respiratory symptoms (phase I study). Of these, 401 subjects who reported wheeze within the previous 12 months (current wheeze) and 213 non-symptomatic controls were randomly selected and investigated with allergy screening, methacholine bronchoprovocation test and measurements of ENO (phase II study).


RESULTS
In the phase I study prevalence of current wheeze was 26% (30% in girls and 23% in boys, P < 0.01). Prevalence of DDA was 10.8% (10.5% in girls and 11% in boys). Among subjects with current wheeze, the likelihood of having DDA was reduced in girls compared to boys, odds ratio (95% CI) 0.82 (0.68-0.98) which was partly explained by a longer history of wheeze among boys. In the phase II study, although more girls than boys with current wheeze had AHR (62% versus 50%, P < 0.02) more boys than girls reported DDA (44% vs. 32%, P < 0.02). Of the objective parameters, increased levels of ENO most strongly increased the risk of having DDA.


CONCLUSIONS
When asthma is defined as DDA, there is a risk of underestimating the prevalence of asthma, especially among girls.
Department of Lung Medicine, University Hospital of Trondheim, Norwegian University of Science and Technology, Trondheim, Norway. anne.h.henriksen@medisin.ntnu.no
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Holmen
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Bjermer
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001249:Asthma / Q000175:diagnosis* / Q000453:epidemiology* / Q000503:physiopathology; D001944:Breath Tests / Q000379:methods; D016535:Bronchial Hyperreactivity / Q000453:epidemiology; D001985:Bronchial Provocation Tests; D002648:Child; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D009569:Nitric Oxide / Q000032:analysis; D009664:Norway / Q000453:epidemiology; D016017:Odds Ratio; D015995:Prevalence; D012135:Respiratory Sounds / Q000503:physiopathology; D017678:Sex Distribution
D009569:Nitric Oxide