Synthesis, anticholinesterase activity and structure-activity relationships of m-Aminobenzoic acid derivatives.
The synthesis, acetylcholinesterase inhibitory capacity and structure-activity relationships of simple-structured m-Aminobenzoic acid derivatives are reported. Compound 1b was found to be more potent than galanthamine and tacrine in inhibiting acetylcholinesterase.
Sección de graduados y Departamento de Bioquímica, Escuela Superior de Medicina del Instituto Politécnico Nacional, Apartado Postal 42-161, C.P. 11340, Mexico City, Mexico. jtrujillo@ipn.mx
José
J
Trujillo-Ferrara
Leticia
L
Montoya Cano
Michel
M
Espinoza-Fonseca
D010129:4-Aminobenzoic Acid / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D010129:4-Aminobenzoic Acid