Serum concentration of D-dimers as a marker of the activation of the fibrinolytic system in patients undergoing bronchoscopic and thoracoscopic investigations.
BACKGROUND
Hypercoagulability is common even after minimally invasive surgical techniques and is pathogenetically linked to postoperative thrombotic and cardiac complications. The activation of the coagulation and fibrinolytic systems after bronchoscopic and thoracoscopic investigations has not yet been elucidated.


OBJECTIVE
The aim of our study was to evaluate whether bronchoscopic and thoracoscopic investigations activate the fibrinolytic system.


METHODS
This study assessed cross-linked fibrinogen degradation products (D-dimer) in 120 patients after bronchoscopy with and without biopsies and/or bronchoalveolar lavage and after thoracoscopy with biopsies of the parietal pleura.


RESULTS
Both bronchoscopy and thoracoscopy induced a minor but significant increase in D-dimers in most patients, reversible mostly within 24 h. In rare cases, distinct increases lasting at least 24 h occurred.


CONCLUSIONS
The slight and temporary increase in serum D-dimers induced by bronchoscopy and thoracoscopy is nonsignificant in most patients; however, in some cases, the coagulation/fibrinolytic systems may become markedly activated.
Department of Pulmonology, Municipal Hospital of Dessau, Dessau, Germany. skd.innere2@t-online.de
J
J
Schreiber
J
J
Knolle
R
R
Lüdicke
G
G
Florschütz
W
W
Rosahl
D000933:Antifibrinolytic Agents / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis*; D001999:Bronchoscopy; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D013906:Thoracoscopy
D000933:Antifibrinolytic Agents; D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D