[Biochemical remodeling of myocardial collagen and its relation to cardiac renin-angiotensin system in rats after myocardial infarction].
OBJECTIVE
This study aimed at the biochemical remodeling of myocardial collagen and its relation to cardiac renin-angiotensin system (RAS) after myocardial infarction(MI).


METHODS
The ventricular and plasma angiotensin II (Ang II) content, total collagen content, and collagen concentration in left ventricle(LV) and right ventricle(RV) of MI and sham-operated control(SOC) rats on 3, 15 and 42 days after operation were measured dynamically by means of radioimmunoassay etc.


RESULTS
The plasma Ang II content increased only in MI rats on day 3. The Ang II content in LV of the MI group increased markedly on day 3 after MI as compared with that of the SOC group. It sustained at this higher level on the 15th and 42th days, and the similar changes were observed in RV as well. The biochemical remodeling of collagen in LV and RV occurred after MI and the remodeling of collagen showed similar patterns with its Ang II content, except that collagen remodeling in RV was delayed than the change of Ang II content.


CONCLUSIONS
The cardiac RAS was obviously activated after MI. Ventricular Ang II might play an important role in the biochemical remodeling of myocardial collagen, and its role was independent of circulating RAS.
Department of Pathophysiology, School of Basic Medical Sciences, WCUMS, Chengdu 610041, China.
Y
Y
Huang
L
L
Lei
G
G
Gao
S
S
Wang
X
X
Sun
D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012084:Renin-Angiotensin System / Q000502:physiology*
D000804:Angiotensin II; D003094:Collagen