Protein carbonylation in human diseases.
Oxidative modifications of enzymes and structural proteins play a significant role in the aetiology and/or progression of several human diseases. Protein carbonyl content is the most general and well-used biomarker of severe oxidative protein damage. Human diseases associated with protein carbonylation include Alzheimer's disease, chronic lung disease, chronic renal failure, diabetes and sepsis. Rapid recent progress in the identification of carbonylated proteins should provide new diagnostic (possibly pre-symptomatic) biomarkers for oxidative damage, and yield basic information to aid the establishment an efficacious antioxidant therapy.
Dalle-Donne
Isabella
I
Department of Biology, University of Milan, via Celoria 26, I-20133 Milan, Italy. quack@mailserver.unimi.it
Giustarini
Daniela
D
Colombo
Roberto
R
Rossi
Ranieri
R
Milzani
Aldo
A
D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use; D004194:Disease; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
D000975:Antioxidants; D011506:Proteins; D017382:Reactive Oxygen Species