Deficiency of Mbd2 suppresses intestinal tumorigenesis.
Gene silencing through de novo methylation of CpG island promoters contributes to cancer. We find that Mbd2, which recruits co-repressor complexes to methylated DNA, is essential for efficient tumorigenesis in the mouse intestine. As Mbd2-deficient mice are viable and fertile, their resistance to intestinal cancer may be of therapeutic relevance.
Sansom
Owen J
OJ
Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, UK.
Berger
Jennifer
J
Bishop
Stefan M
SM
Hendrich
Brian
B
Bird
Adrian
A
Clarke
Alan R
AR
D000236:Adenoma / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D000818:Animals; D018899:CpG Islands; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000172:deficiency* / Q000235:genetics; D020868:Gene Silencing; D017491:Genes, APC; D006579:Heterozygote; D006720:Homozygote; D007414:Intestinal Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout
D004268:DNA-Binding Proteins; C115368:MBD2 protein