Protecting against cocaine, heroin, and sarin gas.
The first X-ray structure of human carboxylesterase 1 (hCE1) and the structures of hCE1 with drug analogs bound reveal important molecular details of how the drugs cocaine, heroin, and tacrine are metabolized and cleared.
McRee
Duncan
D
Syrrx, Inc., 10410 Science Center Drive, San Diego, CA 92121, USA.
D001711:Biotransformation; D043182:Carboxylesterase / Q000737:chemistry* / Q000378:metabolism*; D002619:Chemical Warfare Agents / Q000378:metabolism* / Q000506:poisoning; D003042:Cocaine / Q000378:metabolism* / Q000506:poisoning; D062787:Drug Overdose / Q000188:drug therapy; D003932:Heroin / Q000378:metabolism* / Q000506:poisoning; D006801:Humans; D008958:Models, Molecular; D009294:Narcotics / Q000378:metabolism* / Q000506:poisoning; D011485:Protein Binding; D012524:Sarin / Q000378:metabolism* / Q000506:poisoning
D002619:Chemical Warfare Agents; D009294:Narcotics; D003932:Heroin; D012524:Sarin; D043182:Carboxylesterase; D003042:Cocaine