[Study on the absorption of environmental contaminants in low-level exposure by pharmacokinetic analysis].
A dynamic generating toxic gas system and a nose-only exposure system were used for the pharmacokinetic study of inhaled environmental contaminants for benzene, toluene, xylene, ethylbenzene, chlorobenzene, styrene, isopropyl benzene, tetrachloroethylene, nonane and methylcyclohexane in male guinea pig. The change of these substances in blood with time was determined simultaneously by solid phase micro-extraction(SPME) gas chromatography (GC). The results showed that the fraction of absorption of benzene at low (121 micrograms/m3) exposure was 4.8 times higher than that at high(12.1 mg/m3) exposure. The pharmacokinetics of these substances were evaluated by using linear compartment models. The data showed that more styrene was absorbed than tetrachloroethylene at low-exposure. The metabolic elimination of these compounds at various exposure concentrations was extrapolated by using estimated pharmacokinetic parameters. Moreover, not only should the differences in absorption quantities be considered in evaluation of potential risk assessment, the metabolic elimination rates should also be considered although the exposure concentrations in gas for all chemicals were equal. The data presented in this paper was fundamental data used for risk assessment.
Hao
S
S
Institute of Environment Health Monitoring, Chinese Academy Preventive Medicine, Beijing 100021, China.
Yin
S
S
Li
G
G
Cui
J
J
D000393:Air Pollutants / Q000493:pharmacokinetics; D000818:Animals; D001554:Benzene / Q000493:pharmacokinetics*; D002849:Chromatography, Gas / Q000379:methods; D004781:Environmental Exposure; D006168:Guinea Pigs; D016014:Linear Models; D008297:Male; D013343:Styrenes / Q000493:pharmacokinetics*; D013750:Tetrachloroethylene / Q000493:pharmacokinetics*
D000393:Air Pollutants; D013343:Styrenes; D001554:Benzene; D013750:Tetrachloroethylene