Toxoplasma gondii retinochoroiditis after cardiac transplantation.
OBJECTIVE
To report 4 cases of Toxoplasma gondii retinochoroiditis in patients having recently undergone cardiac transplantation.


METHODS
Review of medical records for 4 patients presenting retinochoroiditis and evidence of T. gondii infection.


RESULTS
Patient ranged in age from 25 to 53 years. Ocular symptoms began between 3 and 6 months after transplantation. All patients were under immunosuppressive therapy. Foci of retinochoroiditis were observed unilaterally in three patients and bilaterally in one. Intraocular inflammation was minimal in all cases. Serologic responses were highly suggestive of T. gondii as the etiology in all cases; other causes (CMV retinitis and syphilis) were actively sought and were not found. All patients underwent classic therapy. The three unilateral cases evolved favorably, but the bilateral case, seen late, showed extensive macular scarring.


CONCLUSIONS
Infectious retinochoroiditis is a potentially blinding complication seen after cardiac transplantation, justifying close clinical and serological surveillance or, in certain cases such as mismatched donors, anti-parasitic prophylaxis.
Ophthalmology Department, Timone Hospital, 264, rue Saint Pierre, 13385, Marseille, France. johnconrath@yahoo.fr
John
J
Conrath
Annick
A
Mouly-Bandini
Frederic
F
Collart
Bernard
B
Ridings
D000328:Adult; D000913:Antibodies, Protozoan / Q000097:blood; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D002825:Chorioretinitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004359:Drug Therapy, Combination; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005451:Fluorescein Angiography; D006084:Graft Rejection / Q000188:drug therapy; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011739:Pyrimethamine / Q000627:therapeutic use; D013411:Sulfadiazine / Q000627:therapeutic use; D014126:Toxoplasmosis, Ocular / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
D000913:Antibodies, Protozoan; D000981:Antiprotozoal Agents; D007166:Immunosuppressive Agents; D013411:Sulfadiazine; D011739:Pyrimethamine