Depersonalisation disorder: clinical features of 204 cases.
BACKGROUND
Depersonalisation disorder is a poorly understood and underresearched syndrome.


OBJECTIVE
To carry out a large and comprehensive clinical and psychopathological survey of a series of patients who made contact with a research clinic.


METHODS
A total of 204 consecutive eligible referrals were included: 124 had a full psychiatric examination using items of the Present State Examination to define depersonalisation/derealisation and 80 had either a telephone interview (n=22) or filled out a number of self-report questionnaires. Cases assessed were diagnosed according to DSM-IV criteria.


RESULTS
The mean age of onset was 22.8 years; early onset was associated with greater severity. There was a slight male preponderance. The disorder tended to be chronic and persistent. Seventy-one per cent met DSM-IV criteria for primary depersonalisation disorder. Depersonalisation symptom scores correlated with both anxiety and depression and a past history of these disorders was commonly reported. 'Dissociative amnesia' was not prominent.


CONCLUSIONS
Depersonalisation disorder is a recognisable clinical entity but appears to have significant comorbidity with anxiety and depression. Research into its aetiology and treatment is warranted.
Hartside Unit, St Nicholas Hospital, Gosforth, Newcastle NE3 3XT, London.
Dawn
D
Baker
Elaine
E
Hunter
Emma
E
Lawrence
Nicholas
N
Medford
Maxine
M
Patel
Carl
C
Senior
Mauricio
M
Sierra
Michelle V
MV
Lambert
Mary L
ML
Phillips
Anthony S
AS
David
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000704:Analysis of Variance; D001007:Anxiety / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D015331:Cohort Studies; D015897:Comorbidity; D003861:Depersonalization / Q000453:epidemiology / Q000209:etiology / Q000523:psychology*; D003863:Depression / Q000453:epidemiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors