Hypersensitivity reactions to non-beta-lactam antibiotics.
As alternatives to beta lactam antibiotics continue to be developed, an increasing number of patients are experiencing hypersensitivity reactions to these agents. Unfortunately, unlike penicillin, there are no validated skin testing reagents to aid in confirming the presence of specific IgE antibodies to these drugs. This review summarizes what is known about hypersensitivity reactions to non-beta lactam antibiotics, and includes practical approaches to readministering these drugs in selected situations. Sulfonamides, vancomycin, macrolides, tetracyclines, fluoroquinolones, and anti-virals are included in the discussion.
Tilles
Stephen A
SA
ASTHMA Inc., Seattle, WA, USA.
Slatore
Christopher G
CG
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000145:classification; D000998:Antiviral Agents / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality; D024841:Fluoroquinolones / Q000009:adverse effects; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced / Q000175:diagnosis / Q000401:mortality; D015994:Incidence; D018942:Macrolides / Q000009:adverse effects; D013449:Sulfonamides / Q000009:adverse effects; D013754:Tetracyclines / Q000009:adverse effects; D014640:Vancomycin / Q000009:adverse effects; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D024841:Fluoroquinolones; D018942:Macrolides; D013449:Sulfonamides; D013754:Tetracyclines; D047090:beta-Lactams; D014640:Vancomycin