Synthesis and anti-inflammatory activity of 5-(6-methyl-2-substituted 4-pyrimidinyloxymethyl)-1,3,4-oxadiazole-2-thiones and their 3-morpholinomethyl derivatives.
The synthesis of 5-(6-methyl-2-substituted 4-pyrimidinyloxymethyl)-2,3-dihydro-1,3,4-oxadiazole-2-thiones and their 3-morpholinomethyl derivatives and the results of anti-inflammatory activity in vivo are described. Most of the tested compounds exhibited anti-inflammatory activity and some of them were more active than acetylsalicylic acid.
Jakubkiene
Virginija
V
Faculty of Chemistry, Vilnius University, Naugarduko 24, 2006, Vilnius, Lithuania. virginija.jakubkiene@chf.vu.lt
Burbuliene
Milda Malvina
MM
Mekuskiene
Giedrute
G
Udrenaite
Emilija
E
Gaidelis
Povilas
P
Vainilavicius
Povilas
P
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D001241:Aspirin / Q000494:pharmacology; D001546:Bentonite; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D006614:Hindlimb; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009025:Morpholines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D023382:Toxicity Tests, Acute
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009025:Morpholines; D010069:Oxadiazoles; D011743:Pyrimidines; D001546:Bentonite; D002351:Carrageenan; D001241:Aspirin