Highly efficient Lewis acid-catalysed Pictet-Spengler reactions discovered by parallel screening.
High yielding Lewis acid-catalysed one-pot Pictet-Spengler reactions of tryptophan methyl ester and tryptamine with aliphatic and aromatic aldehydes were achieved in short reaction times with the aid of microwave irradiation.
Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Southampton, United Kingdom SO17 1BJ.
Natarajan
N
Srinivasan
A
A
Ganesan