Tumor necrosis factor-alpha production-regulating activity of phthalimide derivatives in genetically modified murine melanoma cells B78H1.
The effect of imides, monothioimides, trimellitimides, as well as 5'-deoxy-5'-phthaloylamino-derivatives of azidothymidine on tumor necrosis factor-alpha (TNF-alpha) production by genetically modified murine B78H1 melanoma cells transduced with the gene for human TNF-alpha (B78/TNF) was investigated. It was found that N-(adamant-1-yl)monothiophthalimide (1e) and N-(adamant-2-yl)-monothiophthalimide (1f) showed over 200% enhancing of TNF-alpha production while some of imides were inhibitors.
Institute of Chemistry, Agricultural University, ul. Nowoursynowska 159c, 02-787 Warsaw, Poland. orzeszkoa@delta.sggw.waw.pl
Andrzej
A
Orzeszko
Witold
W
Lasek
Tomasz
T
Switaj
Magdalena
M
Stoksik
Beata
B
Kamińska
D000818:Animals; D015195:Drug Design; D008545:Melanoma; D051379:Mice; D010797:Phthalimides / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
D010797:Phthalimides; D014409:Tumor Necrosis Factor-alpha; D015215:Zidovudine