Hybrid virus-polymer materials. 1. Synthesis and properties of PEG-decorated cowpea mosaic virus.
Cowpea mosaic virus was derivatized with poly(ethylene glycol) to give well-controlled loadings of polymer on the outer surface of the coat protein assembly. The resulting conjugates displayed altered densities and immunogenicities, consistent with the known chemical and biological properties of PEG. These studies make CPMV potentially useful as a tailored vehicle for drug delivery.
Department of Chemistry, The Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA.
Krishnaswami S
KS
Raja
Qian
Q
Wang
María José
MJ
Gonzalez
Marianne
M
Manchester
John E
JE
Johnson
M G
MG
Finn
D000818:Animals; D017798:Comovirus / Q000737:chemistry* / Q000235:genetics; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
D011108:Polymers; D011092:Polyethylene Glycols