Severe infusion reaction induced by trastuzumab: a case report.
We report a case of a severe infusion reaction caused by trastuzumab. A 59-year-old woman with metastatic breast cancer was treated with trastuzumab. During the first infusion, initial symptoms such as severe headache and general fatigue developed. Blood pressure fell 90 minutes after these initial symptoms. A collapsed lung was demonstrated by chest X-ray and computed tomography. Steroid therapy was successfully used for these reactions. Careful monitoring of vital signs, examination of the respiratory system, and the use of steroids are recommended for severe infusion reaction.
Tada
Keiichiro
K
Department of Medical Oncology, Cancer Institute Hospital, 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo 170-8455, Japan. ktada@jfcr.or.jp
Ito
Yoshinori
Y
Hatake
Kiyohiko
K
Okudaira
Taeko
T
Watanabe
Jun-ichiro
J
Arakawa
Masahiro
M
Miyazato
Masayo
M
Irie
Tetsuya
T
Mizunuma
Nobuyuki
N
Takahashi
Syunji
S
Aiba
Keisuke
K
Horikoshi
Noboru
N
Kasumi
Fujio
F
D000707:Anaphylaxis / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology / Q000628:therapy; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008875:Middle Aged; D001261:Pulmonary Atelectasis / Q000139:chemically induced / Q000276:immunology; D013256:Steroids; D000068878:Trastuzumab; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D005938:Glucocorticoids; D013256:Steroids; D000068878:Trastuzumab