No inverse association between fish consumption and risk of death from all-causes, and incidence of coronary heart disease in middle-aged, Danish adults.
This study investigate the relation between fish consumption, all-cause mortality, and incidence of coronary heart disease (CHD). A total of 4,513 men and 3,984 women aged 30-70 years, sampled randomly from the population in Copenhagen County, Denmark, with initially examination in 1982-1992 was followed until 2000 for all-cause mortality and until 1997 for first admission to hospital or death from CHD. Information on fish consumption was obtained from a self-administered food-frequency questionnaire. Cox proportional hazard analysis gave no evidence for an inverse association between fish consumption and all-cause mortality or incident CHD after adjustment for confounders. Among subjects with a priory-defined high risk of CHD there was a nonsignificant inverse relation between fish intake and CHD morbidity (Hazard Ratio 1.28 (0.92-1.80) for a consumption of fish of less than two times per month or less compared with once a week), but there was relatively few cases in this subgroup. These data provides no evidence for a protective effect of fish consumption on all-cause mortality or incident CHD in the population as a whole, but it cannot be excluded that frequent consumption of fish benefits those at high risk for CHD.
Institute of Public Health, University of Copenhagen, Panum Institute, Blegdamsvej 3, 2200 Copenhagen N, Denmark. M.Osler@socmed.ku.dk
Merete
M
Osler
Anne Helms
AH
Andreasen
Susanne
S
Hoidrup
D000328:Adult; D000368:Aged; D000818:Animals; D002423:Cause of Death; D003327:Coronary Disease / Q000453:epidemiology* / Q000517:prevention & control; D003718:Denmark / Q000453:epidemiology; D004032:Diet; D005260:Female; D005399:Fishes; D005500:Follow-Up Studies; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012307:Risk Factors