[GDNF expression following the severe brain injury in rats].
OBJECTIVE
To evaluate the changes of GDNF after severe brain injury.


METHODS
Changes GDNF in cortex, thalamus and pontine was observed by using immunohistochemistry and image analysis technique.


RESULTS
The lever of GDNF was increasing at 1 d, reaching peak at 3 d, not obviously decreasing at 5 d and still higher than normal at 7 d after severe brain injury.


CONCLUSIONS
As an objective indication, the time sequence regularity of GDNF after brain injury may be applied in brain injury time estimation.
Forensic Pathology Department, School of Legal Medicine, Sichuan University, Chengdu 610041. xinwang974@sohu.com
Xin
X
Wang
Zhi-gang
ZG
Liao
Min
M
Liu
D000818:Animals; D015415:Biomarkers; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism*; D005260:Female; D005554:Forensic Medicine; D051100:Glial Cell Line-Derived Neurotrophic Factor; D007091:Image Processing, Computer-Assisted; D008297:Male; D009414:Nerve Growth Factors / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D015415:Biomarkers; C495041:Gdnf protein, rat; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors