A substituted triaza crown ether as a binding site in DNA conjugates.
Synthesis of an asymmetrically substituted triaza crown ether, its incorporation into the 3'-end and 5'-end of ninemer oligonucleotides, and the influence of various alkanediamine ligands on duplex thermostabilities are reported.
Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark.
Stefan
S
Vogel
Katja
K
Rohr
Otto
O
Dahl
Jesper
J
Wengel
D001372:Aza Compounds / Q000737:chemistry*; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D003959:Diamines / Q000737:chemistry; D004988:Ethers, Cyclic / Q000737:chemistry*; D006358:Hot Temperature; D008024:Ligands; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*
D001372:Aza Compounds; D003959:Diamines; D004988:Ethers, Cyclic; D008024:Ligands; D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D004247:DNA