A decreased number of c- kit-expressing cells in a patient with afferent loop syndrome.
Following gastrectomy, stasis in the afferent jejunal loop accompanied by an overgrowth of bacteria leads to a number of clinical symptoms, including the so-called afferent loop syndrome. The disturbances in intestinal motility may be related to stagnation of the intestinal contents in the afferent loop. The pacemaker cells for the basic contractile activity of the intestine are thought to be the interstitial cells of Cajal (ICCs). We and others have reported that ICCs express the c- kit receptor, and that a decreased number of c- kit-expressing ICCs is generally thought to result in disturbed intestinal motility. We report here a patient with postgastrectomy afferent loop syndrome with a decreased number of c- kit-expressing cells in the external muscle layer of the dilated intestine, suggesting damage to the ICCs.
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, B5, Osaka University, 2-2 Yamadaoka, Suita 565-0871, Japan.
Tatsuya
T
Kiyohara
Yasuhisa
Y
Shinomura
Koji
K
Isozaki
Masanori
M
Nakahara
Shusaku
S
Tsutsui
Hiroyuki
H
Nishibayashi
Yoshiji
Y
Miyazaki
Jun-Ichiro
J
Miyagawa
Yuji
Y
Matsuzawa
D000343:Afferent Loop Syndrome / Q000175:diagnosis / Q000378:metabolism*; D001466:Barium Sulfate; D016099:Endoscopy, Gastrointestinal; D005763:Gastroenterostomy / Q000009:adverse effects*; D005769:Gastrointestinal Motility; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000166:cytology; D008297:Male; D008875:Middle Aged; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*; D012086:Reoperation; D013276:Stomach Ulcer / Q000601:surgery
D001466:Barium Sulfate; D019009:Proto-Oncogene Proteins c-kit