[Influenza viruses and atherosclerosis: the role of atherosclerotic plaques in prolonging the persistent form of influenza infection].
It was established that viral particles, like low-density lipoproteins (LDLP), when subjected to some modification changes, lost their ability to be internalized by tissue somatic cells and acquired tropism to macrophage cells. The data, obtained by us by using the polymerase chain reaction (PCR) method, made it possible to assert that atherosclerotic plaques, isolated from vessels of patients with ischemic heart disease (IHD) who underwent coronary bypass, contained RNA of the A(HINI) and AH3N3) influenza viruses. Whereas, the vessel portions, undamaged by atherosclerosis, did not contain any genetic substances of influenza viruses. It was for the first time that an experimentally supported understanding was expressed on that the atherosclerotic plaques serve as a "reservoir" for influenza viruses. It is also suggested that the mentioned plaques can be the carriers of influenza viruses for a long time, thus, prolonging the persistent form of influenza infection in the human body.
V M
VM
Pleskov
A I
AI
Bannikov
V S
VS
Gurevich
Iu V
IuV
Pleskova
D000368:Aged; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology* / Q000821:virology*; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000821:virology; D003331:Coronary Vessels / Q000821:virology*; D006801:Humans; D009980:Influenza A virus / Q000235:genetics* / Q000302:isolation & purification* / Q000378:metabolism; D007251:Influenza, Human / Q000378:metabolism / Q000821:virology*; D015227:Lipid Peroxidation; D008168:Lung / Q000378:metabolism; D008315:Malondialdehyde / Q000032:analysis; D051379:Mice; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000601:surgery / Q000821:virology; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D013053:Spectrophotometry; D013858:Thiobarbiturates; D013997:Time Factors; D018523:Tropism
D012367:RNA, Viral; D013858:Thiobarbiturates; D008315:Malondialdehyde; C029684:thiobarbituric acid