Association of hypocalcemia with a change in gentamicin administration in neonates.
Aminoglycosides are administered frequently to neonates with suspected sepsis. We report the association of hypocalcemia in term and near-term neonates receiving gentamicin therapy for >/=4 days after a change in dosing from every 12 h to every 24 h. The possible association with a higher gentamicin dose and longer dosing interval is described.
Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, USA.
Gregory L
GL
Jackson
Dorothy M
DM
Sendelbach
Elizabeth K
EK
Stehel
Michel
M
Baum
M Denise
MD
Manning
William D
WD
Engle
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001774:Blood Chemical Analysis; D002118:Calcium / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D005839:Gentamicins / Q000009:adverse effects*; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced* / Q000453:epidemiology; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002118:Calcium