HIV treatment-associated hepatitis.
Combination antiretroviral therapy, as well as a variety of other medications prescribed, places patients with HIV disease at high risk for adverse drug reactions and interactions. Sever hepatitis has been reported with all of the currently available classes of antiretroviral agents. Physicians should be aware of the risk of hepatocellular injury in patients receiving antiretroviral therapy and monitor transaminase levels in those at risk. This article reviews the incidence, clinical features, risk factors, and etiology of drug-induced hepatitis with various combinations used in clinical practice.
HIV/AIDS Program, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USA.
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Orenstein
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LeGall-Salmon
D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D000637:Transaminases / Q000097:blood
D000637:Transaminases