ER export: call 14-3-3.
Forward transport of proteins from the ER to the plasma membrane requires escape from the ER's retention machinery. Recent studies suggest that 14-3-3 proteins may mediate ER export of potassium channels destined for the plasma membrane by interfering with dibasic-motif-mediated retention.
Nufer
Oliver
O
Biozentrum, University of Basel, Klingelbergstrasse 70, Switzerland.
Hauri
Hans-Peter
HP
D048948:14-3-3 Proteins; D020816:Amino Acid Motifs; D000818:Animals; D020756:Coatomer Protein / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D015221:Potassium Channels / Q000378:metabolism; D021381:Protein Transport; D015398:Signal Transduction; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D048948:14-3-3 Proteins; D020756:Coatomer Protein; D015221:Potassium Channels; D014446:Tyrosine 3-Monooxygenase