Shock-like sensations during venlafaxine withdrawal.
Electric shock-like sensations may occur after cessation of treatment with serotonin selective reuptake inhibitors but are reported in the literature only rarely with discontinuation of venlafaxine. Two patients experienced severe shock-like sensations during venlafaxine withdrawal. For both patients symptoms occurred with lowering of the dosage and persisted for 5 days after complete discontinuation of the drug. These sensations may represent significant alteration of neuronal activity in the central nervous system.
Reeves
Roy R
RR
Department of Psychiatry, Montgomery VA Medical Center, and the School of Medicine, University of Mississippi, Jackson, Mississippi 39216, USA. roy.reeves@med.va.gov
Mack
James E
JE
Beddingfield
John J
JJ
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000009:adverse effects*; D003511:Cyclohexanols / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012678:Sensation Disorders / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D000069470:Venlafaxine Hydrochloride
D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D000069470:Venlafaxine Hydrochloride