Peptide growth factors and intestinal adaptation in short bowel syndrome.
Intestinal adaptation is the term applied to progressive recovery from intestinal failure following a loss of intestinal length. The regulation of intestinal adaptation is maintained through a complex interaction of many different factors. These include nutrients and other luminal constituents, hormones, and peptide growth factors. The current paper discusses the role of peptide growth factors in intestinal adaptation following massive small bowel resection. This review focuses on the mechanisms of action of peptide growth factors in intestinal cell proliferation, and summarizes the effects of these factors on intestinal regrowth in an animal model of short bowel syndrome.
Sukhotnik
Igor
I
Department of Surgery B, Carmel Medical Center, Haifa, Israel. igor-dr@internet-zahav.net
Siplovich
Leonardo
L
Krausz
Michael M
MM
Shiloni
Eitan
E
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000502:physiology; D007422:Intestines / Q000502:physiology*; D051379:Mice; D010455:Peptides; D051381:Rats; D020127:Recovery of Function / Q000502:physiology; D012778:Short Bowel Syndrome / Q000503:physiopathology* / Q000534:rehabilitation
D006133:Growth Substances; D010455:Peptides