Trypanosoma cruzi clonal diversity and the epidemiology of Chagas' disease.
Chagas' disease is caused by the protozoan Trypanosoma cruzi and it has a variable clinical outcome. The basis for this variability relies in part on the complexity of the parasite population consisting of multiple clones displaying distinct biological properties. A major current challenge is to correlate parasite genetic variability with pathogenesis.
Michael Heidelberg Division of Immunology, Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. busac01@med.nyu.edu
Carlos A
CA
Buscaglia
Javier M
JM
Di Noia
D000818:Animals; D014355:Chagas Disease / Q000453:epidemiology* / Q000469:parasitology; D014644:Genetic Variation; D006801:Humans; D014349:Trypanosoma cruzi / Q000145:classification* / Q000235:genetics* / Q000472:pathogenicity