Small cell carcinoma of the bladder: a case report and a literature review.
OBJECTIVE
To report a case of small cell carcinoma of the bladder. To analyse Literature data concerning disease stage, treatment and prognosis of small cell carcinoma of the bladder.


RESULTS
We report a case of small cell carcinoma of the bladder with hepatic and skeletal metastases who underwent radical cystectomy and systemic chemotherapy. The patient died 9 months after surgery because of chemotherapy complications and in disease progression. The Authors reviewed and analysed Literature data concerning 139 cases of bladder small cell carcinoma with available follow-up.


CONCLUSIONS
The extreme variability of treatment options, the small number of cases and stratification by stages make it very difficult to deduce therapeutic recommendations. The management that seems to give a better survival is the combination of radical cystectomy (or radiotherapy) and chemotherapy.
Department of Urology, University of Verona, Italy.
Orietta
O
Dalpiaz
Najati
N
al Rabi
Antonio
A
Galfano
Guido
G
Martignoni
Vincenzo
V
Ficarra
Walter
W
Artibani
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000556:secondary; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000401:mortality / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D015653:Cystectomy; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D017809:Fatal Outcome; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000009:adverse effects; D015993:Life Tables; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000209:etiology; D016019:Survival Analysis; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D016190:Carboplatin; D002945:Cisplatin; D007069:Ifosfamide