Characterization of a novel coronavirus associated with severe acute respiratory syndrome.
In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.
National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. prota@cdc.gov
Paul A
PA
Rota
M Steven
MS
Oberste
Stephan S
SS
Monroe
W Allan
WA
Nix
Ray
R
Campagnoli
Joseph P
JP
Icenogle
Silvia
S
Peñaranda
Bettina
B
Bankamp
Kaija
K
Maher
Min-Hsin
MH
Chen
Suxiong
S
Tong
Azaibi
A
Tamin
Luis
L
Lowe
Michael
M
Frace
Joseph L
JL
DeRisi
Qi
Q
Chen
David
D
Wang
Dean D
DD
Erdman
Teresa C T
TC
Peret
Cara
C
Burns
Thomas G
TG
Ksiazek
Pierre E
PE
Rollin
Anthony
A
Sanchez
Stephanie
S
Liffick
Brian
B
Holloway
Josef
J
Limor
Karen
K
McCaustland
Melissa
M
Olsen-Rasmussen
Ron
R
Fouchier
Stephan
S
Günther
Albert D M E
AD
Osterhaus
Christian
C
Drosten
Mark A
MA
Pallansch
Larry J
LJ
Anderson
William J
WJ
Bellini
D000595:Amino Acid Sequence; D017124:Conserved Sequence; D017934:Coronavirus / Q000145:classification / Q000235:genetics; D000086862:Coronavirus M Proteins; D000086462:Coronavirus Nucleocapsid Proteins; D018076:DNA, Complementary; D010450:Endopeptidases / Q000737:chemistry / Q000235:genetics; D016679:Genome, Viral; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D019590:Nucleocapsid Proteins / Q000737:chemistry / Q000235:genetics; D016366:Open Reading Frames; D010802:Phylogeny; D020815:Polyproteins / Q000737:chemistry / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics*; D012324:RNA-Dependent RNA Polymerase / Q000737:chemistry / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid; D045473:Severe acute respiratory syndrome-related coronavirus / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D045169:Severe Acute Respiratory Syndrome / Q000821:virology; D064370:Spike Glycoprotein, Coronavirus; D014158:Transcription, Genetic; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000235:genetics; D014763:Viral Matrix Proteins / Q000737:chemistry / Q000235:genetics; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics*
D000086862:Coronavirus M Proteins; D000086462:Coronavirus Nucleocapsid Proteins; D018076:DNA, Complementary; C000706237:M protein, SARS-CoV; D008562:Membrane Glycoproteins; D019590:Nucleocapsid Proteins; D020815:Polyproteins; D012333:RNA, Messenger; D012367:RNA, Viral; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins; D014763:Viral Matrix Proteins; D014764:Viral Proteins; D012324:RNA-Dependent RNA Polymerase; D010450:Endopeptidases