Evaluation of commercial antiglobulin sera over a two-year period. Part I. Anti-beta 1A, anti-alpha 2D, and anti-beta 1E levels.
Antiglobulin sera from nine different manufacturers have been tested, over a two-year period, for their ability to detect the complement components beta 1A, alpha 2D, and beta 1E. The results demontrate considerable variation in the abilities of sera from different manufacturers to detect these components and indicate that not all sera on the market are suitable reagents for diagnostic use and compatibility tests. The results also show that there is considerable variation between different lots of serum from some of the manufacturers. In general, the anti-complement levels of these reagents have increased during the two-year period of study but not all companies produce suitable reagents for routine use.
Issitt
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Paul I. Hoxworth Blood Center of the University of Cincinnati, Cincinnati, Ohio, 45229, USA.
Issitt
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Wilkinson
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D000888:Antibodies, Anti-Idiotypic / Q000097:blood / Q000276:immunology*; D003169:Complement Inactivator Proteins / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis*; D003298:Coombs Test; D006801:Humans
D000888:Antibodies, Anti-Idiotypic; D003169:Complement Inactivator Proteins; C012749:anticomplement; D003165:Complement System Proteins