Constitutive modeling of porcine coronary arteries using designed experiments.
The development of new coronary artery constitutive models is of critical importance in the design and analysis of coronary replacement grafts. In this study, a two-parameter logarithmic complementary energy function, with normalized measured force and internal pressure as the independent variables and strains as the dependent variables, was developed for healthy porcine coronary arteries. Data was collected according to an experimental design with measured force ranging from 9.8 to 201 mN and internal pressure ranging from 0.1 to 16.1 kPa (1 to 121 mmHg). Comparisons of the estimated constitutive parameters showed statistically significant differences between the left anterior descending [LAD] and right coronary artery [RCA], but no differences between the LAD and left circumflex [LCX] or between the LCX and RCA. Point-by-point strain comparisons confirm the findings of the model parameter study and isolate the difference to the axial strain response. Average axial strains for the LAD, LCX, and RCA are 0.026 +/- 0.009, 0.015 +/- 0.005, and 0.011 +/- 0.009, respectively, at all physiologic loads, suggesting that the axial strains in the LAD are significantly higher than in the other regions.
Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0405, USA. stacey.dixon@stanfordalumni.org
Stacey A
SA
Dixon
Russell G
RG
Heikes
Raymond P
RP
Vito
D000818:Animals; D001158:Arteries / Q000502:physiology*; D001794:Blood Pressure; D003198:Computer Simulation; D003331:Coronary Vessels / Q000502:physiology; D004548:Elasticity; D005260:Female; D066298:In Vitro Techniques; D008955:Models, Cardiovascular; D009038:Motion; D011312:Pressure; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013312:Stress, Physiological; D013552:Swine