In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine.
Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC(50) values less than 10 microg/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratum had the strongest antiplasmodial activity with EC(50) value of 0.5 microg/ml. Activity-guided fractionation led to identification of berberine as the major active constituent.
Tran
Quan Le
QL
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Japan.
Tezuka
Yasuhiro
Y
Ueda
Jun-ya
JY
Nguyen
Nhan Trung
NT
Maruyama
Yukiko
Y
Begum
Khurshida
K
Kim
Hye-Sook
HS
Wataya
Yusuke
Y
Tran
Qui Kim
QK
Kadota
Shigetoshi
S
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects*; D014744:Vietnam
D000962:Antimalarials; D010936:Plant Extracts