Primary cutaneous diffuse large B cell lymphoma: a clinically aggressive case.
An 80-year-old woman was diagnosed with primary cutaneous B cell lymphoma. She had multifocal cutaneous tumors, but no nodal lymphadenopathy or bone marrow involvement. Histopathological examination of a biopsy specimen showed diffuse large B cell lymphoma without a bcl-2 expression. Complete resolution of hypercalcemia and disappearance of tumors were achieved with CHOP therapy, but a rapidly progressive skin lesion was observed soon after the completion of the therapy. The clinical manifestation of primary cutaneous diffuse large B cell lymphoma is diverse and the treatment strategy is not entirely clarified. This case represents another example of this rare lymphoma.
Narimatsu
Hiroto
H
Department of Hematology and Oncology, JA Aichi Showa Hospital Aichi.
Morishita
Yoshihisa
Y
Shimada
Kazuyuki
K
Ozeki
Kazutaka
K
Kohno
Akio
A
Kato
Yukio
Y
Nagasaka
Tetsuro
T
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*
D019253:Proto-Oncogene Proteins c-bcl-2