The replicon theory 40 years: an EMBO workshop held in Villefranche sur Mer, France, January 18-23, 2003.
It is now 40 years since Jacob, Brenner, and Cuzin presented their Replicon Theory at a Cold Spring Harbor Symposium. The theory was based on their fundamental studies of the sexual system of Escherichia coli which led to the realisation that only specific sequences are able to replicate. They introduced the concept of a replicon consisting of a replicator (a DNA sequence) and a structural gene for an initiator protein. They also proposed a model for how replication of the bacterial chromosome might fit into the bacterial cell cycle. To commemorate the anniversary, an EMBO Workshop was organised in Villefranche on the Riviera of France. During the Workshop, the state of the art of cell-cycle studies of prokaryotic and eukaryotic organisms was presented and discussed in the presence of two of the fathers of the Replicon Theory, Jacob and Cuzin.
Nordström
Kurt
K
Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, Box 596, S-751 24 Uppsala, Sweden. kurt.nordstrom@icm.uu.se
D000818:Animals; D018407:Bacterial Physiological Phenomena; D002453:Cell Cycle; D004261:DNA Replication; D004926:Escherichia coli / Q000378:metabolism; D008954:Models, Biological; D010957:Plasmids; D012045:Regulatory Sequences, Nucleic Acid; D018741:Replication Origin; D012093:Replicon; D012441:Saccharomyces cerevisiae / Q000378:metabolism / Q000502:physiology; D012568:Schizosaccharomyces / Q000502:physiology