Palladium-catalyzed synthesis of novel optically active tryptophan analogues.
[reaction: see text] Both unsaturated proline derivatives and optically active tryptophan analogues have been obtained via Pd-catalyzed cyclization of aniline-containing acetylenic amino acids. The side chain length of the cyclization precursor determines which one of the two possible products will be formed.
Departments of Organic and Inorganic Chemistry, NSRIM, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.
Bart C J
BC
van Esseveldt
Floris L
FL
van Delft
René
R
de Gelder
Floris P J T
FP
Rutjes