Synthesis and antimicrobial activities of some isocoumarin and dihydroisocoumarin derivatives.
A new series of the isocoumarin derivatives of ibuprofen, fluribiprofen, naproxen, valproic acid and 1-naphthoic acid have been synthesized via condensation of homophthalic acid with their respective acid chlorides. The conversion of the latter two isocoumarins into (dl)-3,4-dihydroisocoumarins has also been achieved. Most of the synthesized compounds showed antifungal and antibacterial activities.
Hussain
M
M
Department of Chemistry, Quaid-I-Azam University, Islamabad, Pakistan.
Hussain
Muhammad T
MT
Rama
Nasim H
NH
Hameed
S
S
Malik
A
A
Khan
Khalid M
KM
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003374:Coumarins