Cerebral atypical teratoid/rhabdoid tumor of infancy: long-term survival after multimodal treatment, also including triple intrathecal chemotherapy and gamma knife radiosurgery--case report.
Cerebral atypical teratoid/rhabdoid tumors (AT/RT) of infancy are highly malignant and have a poor prognosis. The authors report on one case with long-term survival. The patient was a 1 year-old boy presenting with a large AT/RT in the right temporal lobe. He was treated with complete surgery, followed by multiagent chemotherapy. Later he had a second resection and intrathecal chemotherapy and Gamma knife radiosurgery was added to the treatment. Except for a well-controlled temporal epilepsy, the boy is doing well after 6 years follow-up. AT/RT should be treated in a multimodal way. Intrathecal chemotherapy and Gamma knife radiosurgery of single recurrent or residual tumors might increase survival.
Department of Pediatrics, Haukeland University Hospital, Bergen, Norway. asle.hirth@haukeland.no
Asle
A
Hirth
Paal-Henning
PH
Pedersen
Knut
K
Wester
Sverre
S
Mörk
Jon
J
Helgestad
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D007223:Infant; D007278:Injections, Spinal; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local; D016634:Radiosurgery; D018335:Rhabdoid Tumor / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D017741:Survivors; D013724:Teratoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents