The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives.
We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.
Pavlović
Davor
D
Department of Biochemistry, University of Oxford, United Kingdom.
Neville
David C A
DC
Argaud
Olivier
O
Blumberg
Baruch
B
Dwek
Raymond A
RA
Fischer
Wolfgang B
WB
Zitzmann
Nicole
N
D000595:Amino Acid Sequence; D002241:Carbohydrates / Q000494:pharmacology; D016174:Hepacivirus; D007097:Imines / Q000494:pharmacology*; D007473:Ion Channels / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000502:physiology*; D008051:Lipid Bilayers; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D014764:Viral Proteins / Q000737:chemistry / Q000502:physiology*; D000086082:Viroporin Proteins
D002241:Carbohydrates; D007097:Imines; D007473:Ion Channels; D008051:Lipid Bilayers; D010455:Peptides; D014764:Viral Proteins; C088369:p7 protein, Hepatitis C virus; D000086082:Viroporin Proteins