Outcome of pediatric live-donor liver transplantation-the Toronto experience.
OBJECTIVE
Live-donor liver transplantation (LDLT) has developed to address the critical shortage of cadaveric organs that accounts for 20% of children who die while awaiting for a liver transplant in Ontario each year. This report reviews the outcome of the pediatric recipients of LDLT at the authors' center.


METHODS
The charts of all children who received a LDLT between June 1996 and March 2002 were reviewed retrospectively.


RESULTS
Thirteen children (mean age, 3.6 years) underwent LDLT. All donors were parents except for one cousin. Ten grafts were left-lateral segments, 2 were right lobes, and 1 was a left lobe. Three patients required a SILASTIC((R)) (Dow Corning, Midland, MI) patch for delayed abdominal wall closure. Patient and graft survival rate was 100% with a median follow-up of 376 days. Major postoperative complications included biliary leaks (n = 2), biliary strictures (n = 1), portal vein thrombosis (n = 1), and hepatic venous complications (n = 1). There were no cases of hepatic artery thrombosis. Ten of 12 children became Positive for Epstein-Barr virus (EBV), and 3 of these patients had readily treatable post-transplant lymphoproliferative disorder.


CONCLUSIONS
LDLT is an acceptable alternative to cadaveric transplantation for children with end-stage liver disease.
Borenstein
Steven
S
Pediatric Academic Multi-Organ Transplant Program, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada.
Diamond
Ivan R
IR
Grant
David R
DR
Greig
Paul D
PD
Jones
Nicola
N
Ng
Vicky
V
Roberts
Eve
E
Fecteau
Annie
A
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000601:surgery*; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D011183:Postoperative Complications; D012189:Retrospective Studies; D016896:Treatment Outcome