Mitochondria in HIV-1-induced apoptosis.
It is now well admitted that HIV infection leading to AIDS is associated with an abnormal susceptibility of T cells to undergo apoptosis. Recent progress in research into programmed cell death has resulted in the identification of the principal pathways involved in this process. Thus the "extrinsic" as well as the "intrinsic" pathways converge to the mitochondria considered as the main sensor of programmed cell death. This review summarizes our knowledge of the influence of mitochondrial control on T cell death during HIV and SIV infections.
EMI-U 9922 INSERM/Université Paris 7, IFR02, AP-HP, Hôpital Bichat-Claude Bernard, Paris, France.
Damien
D
Arnoult
Frédéric
F
Petit
Jean-Daniel
JD
Lelièvre
Jérôme
J
Estaquier
D000818:Animals; D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D015658:HIV Infections / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D015497:HIV-1 / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D008561:Membrane Fusion; D008928:Mitochondria / Q000502:physiology*; D008954:Models, Biological; D016097:Simian Acquired Immunodeficiency Syndrome / Q000473:pathology / Q000821:virology; D014764:Viral Proteins / Q000494:pharmacology; D014771:Virion / Q000472:pathogenicity; D014779:Virus Replication
D014764:Viral Proteins