Lip hypertrophy secondary to cyclosporin treatment.
Gingival hypertrophy is a well-documented side effect of cyclosporin therapy, but severe lip enlargement is less frequently recognised. This can lead to poor body image, low self-esteem and non-compliance, especially in the older childhood and adolescent age groups. We describe two paediatric renal transplant recipients who had marked lip hypertrophy as a consequence of cyclosporin (Neoral) treatment. On changing the immunosuppression to tacrolimus (Prograf), this resolved. We recommend that a change in immunosuppressant therapy be considered in children with significant changes to facial appearance.
Department of Paediatric Nephrology, Birmingham Children's Hospital, Steelhouse Lane, Birmingham, B4 6NH, UK.
Janette Christine
JC
Cansick
Sally-Anne
SA
Hulton
D002648:Child; D016572:Cyclosporine / Q000009:adverse effects*; D003554:Cystinosis / Q000150:complications / Q000601:surgery; D006801:Humans; D006984:Hypertrophy / Q000139:chemically induced / Q000473:pathology; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007674:Kidney Diseases / Q000150:complications / Q000601:surgery; D016030:Kidney Transplantation / Q000276:immunology; D008047:Lip Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male
D007166:Immunosuppressive Agents; D016572:Cyclosporine