Mean corpuscular volume (MCV) and the risk of colorectal adenoma in menopausal women.
OBJECTIVE
It has been reported that alcohol intake and folate deficiency are associated with an increased risk of colorectal adenomas and carcinomas. Mean corpuscular volume is increased under these conditions. We have reported that the mean corpuscular volume was higher in patients with adenoma than without adenoma in middle-aged men. The aim of this study was to assess the association between mean corpuscular volume and risk of colorectal adenoma in menopausal women.


METHODS
The subjects were 415 menopausal women who underwent both barium enema examination and total colonoscopy, and their blood samples were analyzed. The subjects were divided into two groups with or without adenoma, and were divided into four groups according to the mean corpuscular volume value. Various variables were compared among the groups, and the odds ratios of adenoma were calculated.


RESULTS
The mean corpuscular volume was higher in patients with adenoma than without adenoma (P = 0.002). As for the mean corpuscular volume value, the odds ratio (95% CI) of patients with adenoma was 1.00 (referent); (mean corpuscular volume (fl) < 90), 1.50 (0.93-2.07); (> or = 90 but < 92.5), 1.52 (0.97-2.07); (> or = 92.5 but < 95) and 2.87 (2.25-3.45); (> or = 95).


CONCLUSIONS
Mean corpuscular volume > or = 95 may be used as an index of the risk for colorectal adenomas in menopausal women.
Third Department of Internal Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.
Shunji
S
Fujimori
Teruyuki
T
Kishida
Keigo
K
Mitsui
Tsuguhiko
T
Seo
Masaoki
M
Yonezawa
Yoshiaki
Y
Shibata
Isao
I
Shinozawa
Shu
S
Tanaka
Atsushi
A
Tatsuguchi
Jun
J
Sato
Yutaka
Y
Yoshida
Kimiyoshi
K
Yokoi
Noritake
N
Tanaka
Yoshiharu
Y
Ohaki
Choitsu
C
Sakamoto
Masafumi
M
Kobayashi
D000236:Adenoma / Q000097:blood* / Q000453:epidemiology; D000368:Aged; D015179:Colorectal Neoplasms / Q000097:blood* / Q000453:epidemiology; D004912:Erythrocytes / Q000166:cytology*; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D016017:Odds Ratio; D018570:Risk Assessment