Decreased transfusion requirements in patients given stem cell allografts using a non-myeloablative conditioning regimen: a single institution experience.
We report our experience of allogeneic peripheral blood stem cell transplantation using non-myeloablative conditioning regimens delivered and supported on an outpatient basis. A group of 44 patients underwent 47 allograft procedures using peripheral blood stem cells. Approximately one third of the individuals did not require red blood cells transfusions: the median of transfused red blood cells units was 1 (range 0-10). In addition one out of three did not require platelet transfusions either, the median of platelet transfusions being 1 (range 0-6). In fourteen allografts (30%) neither red blood cells nor platelet transfusions were used. An inverse correlation was found between the number of CD34 cells infused and the PRBC and PLT transfusion requirements, those patients receiving high numbers of CD34 cells needing fewer transfusions of both PRBC and platelets. The possibility of conducting allografts without transfusion of blood products in some patients may result in a decrease in both cost and the risks stemming from exposure to human blood derivatives.
Centro de hematología y Medicina Interna de Puebla, Puebla, Mexico.
Guillermo J
GJ
Ruiz-Argüelles
Briceida
B
López-Martínez
David
D
Gómez-Rangel
Erick
E
Estrada
Antonio
A
Marín-López
Gerardo
G
Bravo-Hernández
Juan
J
Manuel Hernández
D000293:Adolescent; D000328:Adult; D002066:Busulfan; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide; D016572:Cyclosporine; D017707:Erythrocyte Transfusion / Q000706:statistics & numerical data*; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor; D019337:Hematologic Neoplasms / Q000628:therapy*; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D008297:Male; D008727:Methotrexate; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy; D036102:Peripheral Blood Stem Cell Transplantation / Q000706:statistics & numerical data; D017713:Platelet Transfusion / Q000706:statistics & numerical data*; D011446:Prospective Studies; D011994:Recombinant Proteins; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D014740:Vidarabine / Q000031:analogs & derivatives*
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016572:Cyclosporine; D003520:Cyclophosphamide; D014740:Vidarabine; D002066:Busulfan; C024352:fludarabine; D000069585:Filgrastim; D008727:Methotrexate