Unilateral schizencephaly and contralateral polymicrogyria associated with umbilical cord mass.
We report a 6-month-old boy with diffuse hypertonia and developmental delay who had unilateral separated-lip schizencephaly and contralateral polymicrogyria. The contralateral polymicrogyria was associated with an incomplete clefting in that hemisphere. An umbilical cord hamartoma is presumed to have caused hypoperfusion to the early developing brain, resulting in bilateral lesions.
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Lucile Packard Children's Hospital at Stanford, California 94305-5235, USA. jhahn@stanford.edu
Jin S
JS
Hahn
Ann J
AJ
Lewis
D001927:Brain Diseases / Q000209:etiology* / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D002658:Developmental Disabilities / Q000209:etiology; D007839:Functional Laterality; D006222:Hamartoma / Q000150:complications / Q000473:pathology*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications* / Q000196:embryology*; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D014470:Umbilical Cord / Q000473:pathology*