[Neoplastic cell death induced by photodynamic therapy].
The photodynamic therapy (PDT) is a new therapeutic method aimed at selective destruction of neoplastic cells. In PDT photosensitizing pigments are used, introduced into cells and then activated with laser light. This leads to formation of free radicals in the cell (peroxide aminoradical, hydroxyl radical), or singlet oxygen. The outcome is death of neoplastic cells through apoptosis or necrosis. The effect of PDT on the type of cell death depends on the biochemical properties of the photosensitizer used, and exposure time of neoplastic cells to light. The studies on application of PDT are primarily aimed at directing neoplastic cells towards apoptosis.
Saczko
Jolanta
J
Katedry i Zakładu Biochemii Lekarskiej, Akademii Medycznej we Wrocławiu.
Daczewska
Małgorzata
M
Marcinkowska
Anna
A
Saczko
Zbigniew
Z
Banaś
Teresa
T
D017209:Apoptosis / Q000187:drug effects*; D006801:Humans; D009336:Necrosis; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects / Q000378:metabolism
D017319:Photosensitizing Agents; D014409:Tumor Necrosis Factor-alpha