Analgesic, antipyretic, anti-inflammatory effects of methanol, chloroform and ether extracts of Vernonia cinerea less leaf.
The chloroform, methanolic and ether extracts of Vernonia cinerea (Asteraceae; Less) leaf (100, 200 and 400mg/kg intraperitoneally) were tested in: acetic acid-induced writhing in mice, carrageenin-induced oedema and brewer's yeast-induced pyrexia in rats to assess their analgesic, anti-inflammatory, antipyretic and behavioral activities, respectively. The changes in writhings and behavioural activities in mice, the pyrexia and paw volumes in rats were reduced significantly (P<0.05) compared to the control. There was an increase in pain threshold on the oedematous right hind limb paw of the rats. These results indicate that the extracts could possess analgesic, antipyretic and anti-inflammatory properties. All these effects and the changes in the behavioural activities could be suggested as contributory effects to the use of V. cinerea leaf in the treatment of malaria.
Department of Pharmacology, Obafemi Awolowo University, Ile-Ife, Nigeria. eoiwalewa@yahoo.com
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Iwalewa
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Adeboye
D000700:Analgesics / Q000302:isolation & purification / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D002725:Chloroform / Q000494:pharmacology; D008297:Male; D000432:Methanol / Q000494:pharmacology; D051379:Mice; D008517:Phytotherapy; D018515:Plant Leaves; D028321:Plant Preparations / Q000302:isolation & purification / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D035741:Vernonia
D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D028321:Plant Preparations; D002725:Chloroform; D000432:Methanol