Hydrogels for an accommodating intraocular lens. An explorative study.
In this study it was investigated whether hydrogels could be used for an accommodating lens. The requirements of such a hydrogels are a low modulus, high refractive index, transparency, and strength. Since conventional hydrogels do not possess this combination of properties, a novel preparation method and new polymers are introduced. As starting materials poly(1-hydroxy-1,3-propanediyl), poly(ethylene-co-vinyl alcohol), poly(vinyl alcohol), and poly(allyl alcohol) were used. The first three were cross-linked with a number of diisocyanate compounds. Network formation was performed at low concentrations in a good solvent. Mixing of the polymer solution and cross-linker appeared to be crucial for transparency. Poly(1-hydroxy-1,3-propanediyl), cross-linked with a slow reacting diisocyanate block, shows the most promising properties with respect to refractive index, transparency, tensile strength, and modulus. Poly(allyl alcohol) hydrogel was made by compression molding. The hydrogel was transparent and had a high refractive index and low modulus. It was concluded that hydrogels could be used as accommodating lens material.
Pharmacia Groningen BV, Van Swietenlaan 5, 9728 NX Groningen, The Netherlands.
Jacqueline H
JH
de Groot
Coenraad J
CJ
Spaans
Ralph V
RV
van Calck
Folkert J
FJ
van Beijma
Sverker
S
Norrby
Albert J
AJ
Pennings
D000065:Accommodation, Ocular; D019245:Compressive Strength; D003432:Cross-Linking Reagents / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D007910:Lenses, Intraocular
D003432:Cross-Linking Reagents; D020100:Hydrogels