[The roles of VEGF and C-myc in occurrence, development and metastasis of gallbladder carcinoma].
To investigate the relationship of the expression of vascular endothelial growth factor (VEGF) and C-myc with the occurrence, development and metastasis of gallbladder carcinoma, the expression levels of VEGF and C-myc in gallbladder carcinoma tissue (n = 30) and in normal gallbladder tissue (n = 20) were examined by immunochemistry. Results show that the positive rates of VEGF and C-myc in gallbladder carcinoma tissue were 80% and 63.3% respectively, and 45% and 25% respectively in normal gallbladder tissue. The positive rates of VEGF and C-myc were significantly higher in gallbladder carcinoma than in normal gallbladder tissue. The expression of VEGF and C-myc in gallbladder carcinoma related to the metastasis of gallbladder carcinoma. VEGF and C-myc play important roles in the occurrence, development and metastasis of gallbladder carcinoma.
Laboratory of Surgical Department, West China Hospital, Sichuan University, Chengdu 610041.
Zhimin
Z
Liu
Lili
L
Jiang
Bin
B
Yang
Dianying
D
Liao
D000328:Adult; D000368:Aged; D016228:Endothelial Growth Factors / Q000096:biosynthesis* / Q000502:physiology; D005260:Female; D005706:Gallbladder Neoplasms / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis* / Q000502:physiology; D008222:Lymphokines / Q000096:biosynthesis* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis* / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D016271:Proto-Oncogene Proteins c-myc; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors