The G glycoprotein of respiratory syncytial virus depresses respiratory rates through the CX3C motif and substance P.
Respiratory syncytial virus (RSV) infection in the neonate can alter respiratory rates, i.e., lead to episodes of apnea. We show that RSV G glycoprotein reduces respiratory rates associated with the induction of substance P (SP) and G glycoprotein-CX3CR1 interaction, an effect that is inhibited by treatment with anti-G glycoprotein, anti-SP, or anti-CX3CR1 monoclonal antibodies. These data suggest new approaches for treating some aspects of RSV disease.
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. RTripp@cdc.gov
Ralph A
RA
Tripp
Azzeddine
A
Dakhama
Les P
LP
Jones
Albert
A
Barskey
Erwin W
EW
Gelfand
Larry J
LJ
Anderson
D000818:Animals; D001049:Apnea / Q000209:etiology; D000073883:CX3C Chemokine Receptor 1; D020523:Chemokines, CX3C / Q000737:chemistry; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D018121:Receptors, Cytokine / Q000378:metabolism*; D015728:Receptors, HIV / Q000378:metabolism*; D012119:Respiration / Q000187:drug effects*; D018113:Respiratory Syncytial Virus, Human / Q000472:pathogenicity*; D013373:Substance P / Q000378:metabolism*; D014764:Viral Proteins / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology*
D000073883:CX3C Chemokine Receptor 1; D020523:Chemokines, CX3C; D018121:Receptors, Cytokine; D015728:Receptors, HIV; D014764:Viral Proteins; D013373:Substance P