Complete response after chemoradiation in ampullary carcinoma: a case report.
OBJECTIVE
The case of a 70-year-old patient with resectable, poorly differentiated adenocarcinoma of the ampulla of Vater is presented.


METHODS
Due to intraoperative hemorrhagic complications, surgical resection was not feasible. The patient was treated with radiochemotherapy consisting of external beam radiotherapy (50.4 Gy; 1.8 Gy/fraction; 5 fractions/week) plus 5-FU (1000 mg/m2/day, continuous i.v. infusion, days 2-5, week 1 and 5 of radiotherapy) and mitomycin C (10 mg/m2 i.v., day 2, week 1 of radiotherapy).


RESULTS
At five years' follow-up the patient was in good general condition, without any signs of disease according to CT scan, endoscopic retrograde cholangiopancreatography and tumor marker determination. Multiple random biopsies performed in the ampullary region were negative for tumor growth.


CONCLUSIONS
In patients with ampullary carcinoma the use of concurrent chemoradiation should be considered, particularly when surgical resection is unfeasible due to medical contraindications or locally advanced disease.
Radiation Therapy Department, Università Cattolica del Sacro Cuore, Rome, Italy.
Alessio G
AG
Morganti
Gabriella
G
Macchia
Lucio
L
Trodella
Vincenzo
V
Valentini
Guido
G
Costamagna
Massimiliano
M
Mutignani
Andrea
A
Tringali
Daniela
D
Smaniotto
Stefano
S
Luzi
Numa
N
Cellini
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy*; D000368:Aged; D014670:Ampulla of Vater; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003138:Common Bile Duct Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome
D016685:Mitomycin; D005472:Fluorouracil