Current management challenges in HIV: antiretroviral resistance.
Emergence of drug-resistant viral variants is a major reason why HIV-infected patients experience viral rebound during antiretroviral therapy. Although combination antiretroviral therapy substantially inhibits viral replication, replication-competent mutant virus remains. In addition, it is now clear that virologic failure is not necessarily caused by failure of all drugs in a regimen. The use of resistance-testing data can assist in understanding the reasons for failure of antiretroviral therapy. However, there is a need for additional trials to better define the role resistance testing may play in developing management approaches to mitigate or minimize emergence of resistant HIV.
Kuritzkes
Daniel R
DR
Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.
Boyle
Brian A
BA
Gallant
Joel E
JE
Squires
Kathleen E
KE
Zolopa
Andrew
A
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D024882:Drug Resistance, Viral; D005838:Genotype; D006678:HIV / Q000145:classification / Q000235:genetics; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D010349:Patient Compliance
D019380:Anti-HIV Agents