Constructing an organ: the Drosophila salivary gland as a model for tube formation.
Tubes are required in metazoans to transport the liquids and gases that sustain life. The conservation of molecules and mechanisms involved in tube formation suggests that what we learn by studying simple systems will apply to related processes in higher animals. Studies over the past 10 years have revealed the molecules that specify cell fate in Drosophila salivary gland and the cellular events that mediate tube morphogenesis. Here, we discuss how anterior-posterior and dorsal-ventral patterning information specifies both the position of salivary-gland primordia and how many cells they contain. We examine the transformation of a polarized epithelial sheet into an elongated, unbranched tube, and the intrinsic and extrinsic factors that influence the final position of the salivary gland.
Dept Cell Biology, The Johns Hopkins University School of Medicine, 725 N. Wolfe St, Baltimore, MD 21205, USA.
Elliott W
EW
Abrams
Melissa S
MS
Vining
Deborah J
DJ
Andrew
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D019521:Body Patterning; D019070:Cell Lineage; D002465:Cell Movement; D004268:DNA-Binding Proteins / Q000502:physiology; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins / Q000502:physiology; D004848:Epithelium / Q000196:embryology / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D019476:Insect Proteins / Q000502:physiology; D016023:Integrins / Q000378:metabolism; D008840:Microfilament Proteins; D008954:Models, Biological; D009154:Mutation; D012097:Repressor Proteins / Q000502:physiology; D012469:Salivary Glands / Q000196:embryology* / Q000502:physiology*; D015398:Signal Transduction; D013997:Time Factors
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; D016023:Integrins; D008840:Microfilament Proteins; D012097:Repressor Proteins; C087725:Hkb protein, Drosophila; C084628:f protein, Drosophila; C489235:hairy protein, Drosophila; C061841:hairy protein, insect