The late endocrine effects of childhood cancer treatment.
Whilst many children diagnosed with cancer can now realistically hope for long term survival, the consequences of cancer treatment can be particularly devastating as they enter adolescence and adulthood. Disruption of the endocrine system can result from such treatment, including growth hormone deficiency, problems in normal pubertal progression and thyroid dysfunction. Fertility can also be affected by cancer treatment received as a child, which can have a devastating impact as the patient enters adulthood. In addition, these children may encounter disorders of growth and bone metabolism due to both their initial disease and aspects of its treatment, resulting in further morbidity in later life. The aetiology and diagnosis of these problems are discussed in this review, along with therapeutic options in order to reduce their impact. Long term follow up and clinical vigilance in this patient group is vital. We must continue to strive towards improved survival from childhood cancer, but equally we must remain aware of the adverse effects of treatment, particularly in the long term, and must aim to reduce the impact of these effects as children enter adolescence and adult life.
Department of Paediatric Haematology and Oncology, Royal Hospital for Sick Children, 17 Millerfield Place, Edinburgh, EH9 1LW, UK.
Mark F H
MF
Brougham
Christopher J H
CJ
Kelnar
W Hamish B
WH
Wallace
D001842:Bone and Bones / Q000378:metabolism; D004700:Endocrine System Diseases / Q000209:etiology* / Q000503:physiopathology; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D007027:Hypothalamic Diseases / Q000209:etiology / Q000503:physiopathology; D009369:Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D010900:Pituitary Diseases / Q000209:etiology / Q000503:physiopathology; D011627:Puberty; D013964:Thyroid Neoplasms / Q000209:etiology / Q000503:physiopathology