Cyclopentanes from N-amino-glyconolactams. A synthesis of mannostatin A.
Oxidation of a N-amino-ribonolactam with lead tetraacetate yields two cyclopentanes; the major one was transformed into the alpha-mannosidase inhibitor mannostatin A.
Hu
Guixian
G
Laboratorium für Organische Chemie, ETH-Hönggerberg, CH-8093 Zürich, Switzerland.
Zimmermann
Martin
M
Ramana
Chepuri Venkata
CV
Vasella
Andrea
A
D000588:Amines / Q000737:chemistry; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry*; D007769:Lactams / Q000737:chemistry*; D008361:Mannosidases / Q000037:antagonists & inhibitors; D009942:Organometallic Compounds / Q000737:chemistry; D010084:Oxidation-Reduction
D000588:Amines; D003517:Cyclopentanes; D007769:Lactams; D009942:Organometallic Compounds; C060107:mannostatin A; C029433:lead tetraacetate; D008361:Mannosidases