Protective effect of vagotomy on the gastric mucosa in a stress model in rats.
BACKGROUND
The use of vagotomy is classically based on its inhibiting effects on acid secretion. Vagotomy induces both cellular and endocrine changes that may be involved in protective actions. Our aim was to study morphologic changes induced by vagotomy on the gastric mucosa and their relation to stress protection in the short, medium and long term.


METHODS
An immobilization and cold stress model was used with 80 Wistar rats divided into two groups--control (with and without stress) and vagotomy (at 7, 30 and 120 days). Changes induced in the gastric mucosa by stress were studied with and without vagotomy, as well as relationship between these changes and the intended protective action.


RESULTS
Bleeding showed a very significant relation to stress (p < 0.0001). Bleeding incidence exhibited a significant difference between vagotomised and non-vagotomised rats (p < 0.0001) in the short, medium and long term (vagotomy was protective against stress). Regeneration signs related significantly to vagotomy (p < 0.0001) but not stress (p = 0.208). However, no significant relationship was found between the protective action and the presence of regeneration signs (p = 1).


CONCLUSIONS
Vagotomy has tropic effects on the gastric mucosa and is protective against stress. This protective action is maintained in the short, medium and long term. However, these changes are not sufficient to explain protection. An adaptation phenomenon mediated by hormonal and peptidic factors may be involved in this action.
General and Digestive System Surgery Department B, H.U. La Paz, Madrid, Spain.
J I
JI
Landa García
A
A
Carabias Hernández
S
S
Rodríguez Dapena
J
J
Alcalde Escribano
L
L
Ortega Medina
J L
JL
Balibrea Cantero
D000818:Animals; D003080:Cold Temperature; D004195:Disease Models, Animal; D005260:Female; D005744:Gastric Acid / Q000502:physiology; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications; D014628:Vagotomy / Q000379:methods*