Anilinopyrimidines as novel antituberculosis agents.
A selection of novel anilinopyrimidine analogues have been found to have micromolar activity against Mycobacterium tuberculosis. This could potentially generate new lead compounds in the fight against multi-drug resistant tuberculosis.
Morgan
Jody
J
Department of Chemistry, University of Wollongong, NSW 2522, Australia.
Haritakul
Rachada
R
Keller
Paul A
PA
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
D000962:Antimalarials; D000995:Antitubercular Agents; D011743:Pyrimidines