Oestrogen and progestin responses in human endometrium.
Our understanding of the mechanisms of the actions of oestrogens and progestins have evolved from the simple concept of nuclear receptor-mediated regulation of transcription to a highly sophisticated, finely tuned interplay between various coregulators, other signaling cascades and transcription factors. The net result of these complex regulatory mechanisms is a steroid-, cell-, or tissue-specific action of oestrogens and progestins, their antagonists or selective modulators of their receptors. In this review, we have attempted to shed some light on the regulation of the actions of oestrogens and progestins on the human endometrium.
Department of Pathology, Research Institute of Growth and Development (GROW), Maastricht University, Postbus 616, 6200 MD Maastricht, The Netherlands.
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Punyadeera
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Verbost
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Groothuis
D002450:Cell Communication; D004717:Endometrium / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D011372:Progestins / Q000378:metabolism*; D011487:Protein Conformation; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D015398:Signal Transduction; D014158:Transcription, Genetic
D004967:Estrogens; D008024:Ligands; D011372:Progestins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone