Transplantation of related histocompatible marrow and peripheral blood stem cells in a patient with severe combined immunodeficiency and disseminated BCG infection.
We report the results of allogeneic bone marrow transplantation (BMT) in a 15-month-old boy with severe combined immunodeficiency (SCID) complicated by disseminated Bacillus Calmette-Guerin (BCG) infection. Slow immunological recovery after BMT is considered to be associated with prolonged BCG infection. After one booster dose of allogeneic peripheral blood stem cell transplantation (PBSCT), there was still little improvement in immune reconstitution. The patient finally expired because of failure to achieve a functioning immune system after BMT and septic shock.
Hung
Giun-Yi
GY
Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
Chiou
Tzeon-Jye
TJ
Lin
Ching-Yuang
CY
Hsiao
Liang-Tsai
LT
Chen
Po-Min
PM
Hwang
Betau
B
D001500:BCG Vaccine / Q000009:adverse effects*; D016026:Bone Marrow Transplantation; D006801:Humans; D007223:Infant; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D016511:Severe Combined Immunodeficiency / Q000276:immunology / Q000628:therapy*; D014376:Tuberculosis / Q000209:etiology*
D001500:BCG Vaccine