Effect of Rhus coriaria L. (Anacardiaceae) on superoxide radical scavenging and xanthine oxidase activity.
Rhus coriaria L. (Anacardiaceae) is a well-known spice in the Middle-East and grown in the Central and East Anatolia region of Turkey. A methanolic extract (water-soluble part constituents) of R. coriaria, was found to be an uncompetitive inhibitor of xanthine oxidase and scavenger of superoxide radical in vitro with IC50 values of 172.5 microg/mL and 232 microg/mL respectively. Superoxide radicals were generated either by an enzymatic or a non-enzymatic system, and scavenging ability was evaluated by the inhibition of nitroblue tetrazolium reduction. This study provides evidence that a crude extract of R. coriaria exhibits interesting antioxidant properties, expressed either by the capacity to scavenge superoxide radical or to uncompetitively inhibit xanthine oxidase.
Faculty of Science and Art, Department of Chemistry, University of Cumhuriyet, 58140 Sivas, Turkey. candan@cumhuriyet.edu.tr
Ferda
F
Candan
D016166:Free Radical Scavengers / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D029045:Rhus / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000494:pharmacology*
D016166:Free Radical Scavengers; D010936:Plant Extracts; D013481:Superoxides; D014969:Xanthine Oxidase