Successful treatment of recurrent, intractable hyperemesis gravidarum with methylprednisolone. A case report.
BACKGROUND
Severe and persistent hyperemesis gravidarum is a disabling condition. Women may request termination of pregnancy because of the intolerable symptoms and stress.


METHODS
A woman requested termination of pregnancy because of severe hyperemesis gravidarum. Her first three pregnancies were also complicated by severe and persistent vomiting. The vomiting was successfully treated with a short course of methylprednisolone.


CONCLUSIONS
Methylprednisolone is an effective treatment for severe hyperemesis gravidarum and should be considered for women whose vomiting is persistent and refractory to conventional therapy.
Chan
Louis Y
LY
Departments of Obstetrics and Gynaecology, Princes of Wales Hospital, Chinese University of Hong Kong, and Princess Margaret Hospital, Shatin, Hong Kong. lyschan@cuhk.edu.hk
Lam
Man Ho
MH
Lau
Tze Kin
TK
Chin
Robert K H
RK
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000175:diagnosis* / Q000188:drug therapy*; D008775:Methylprednisolone / Q000008:administration & dosage*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D012720:Severity of Illness Index
D008775:Methylprednisolone