Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor.
Chlamydia trachomatis heat shock protein 10 (Chsp10) is associated with chronic genital tract infection with C. trachomatis. Chsp10 is homologous to human chaperonin 10 (Cpn10) and early pregnancy factor (EPF), a form of human Cpn10 that is specifically secreted at the start of pregnancy. We investigated cross-reactions between serum anti-Chsp10 antibodies and anti-EPF antibodies in pregnant and nonpregnant patients. Pregnancy was found to be associated with the presence of anti-EPF antibodies, which are specifically induced in pregnant women with a history of C. trachomatis infection, and with the presence of serum anti-Chsp10 antibodies. We also found that infertility was associated with the presence of anti-Chsp10 and anti-EPF antibodies. The HLA class II haplotype DR8 DQ4 was associated with the presence of anti-Chsp10 antibodies but not of anti-EPF antibodies.
Betsou
Fotini
F
Biobanque de Picardie, 16 rue Fernel, 80000 Amiens, France. fay.betsou@biobanque-picardie.com
Borrego
Maria José
MJ
Guillaume
Nicolas
N
Catry
Maria Anjos
MA
Romão
Sandra
S
Machado-Caetano
J A
JA
Sueur
Jean Marie
JM
Mention
Jacques
J
Faille
Nicole
N
Orfila
Jeanne
J
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood; D018835:Chaperonin 10 / Q000276:immunology*; D002690:Chlamydia Infections / Q000276:immunology; D002692:Chlamydia trachomatis / Q000737:chemistry*; D003429:Cross Reactions / Q000276:immunology*; D005260:Female; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; D006239:Haplotypes / Q000276:immunology; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000276:immunology; D008297:Male; D010455:Peptides / Q000276:immunology*; D011247:Pregnancy; D011257:Pregnancy Proteins; D013491:Suppressor Factors, Immunologic
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001323:Autoantibodies; D018835:Chaperonin 10; D006683:HLA-DQ Antigens; C060029:HLA-DQ4 antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C041559:HLA-DR8 antigen; D010455:Peptides; D011257:Pregnancy Proteins; D013491:Suppressor Factors, Immunologic; C025124:early pregnancy factor