The role of NFAT5/TonEBP in establishing an optimal intracellular environment.
NFAT5/TonEBP, the most recently described member of the rel/NFkappaB/NFAT family of signal-dependent transcription factors, is activated by extracellular hypertonicity-a cellular stress of particular and perhaps unique physiologic relevance to cells of the renal medulla. Accumulating evidence suggests that NFAT5/TonEBP also functions in vivo under isotonic conditions as part of a ubiquitous regulatory mechanism that senses and adjusts available intracellular volume during cell growth to establish an intracellular environment appropriate for optimal cell proliferation.
Department of Pathology, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0644, USA. snho@ucsd.edu
Steffan N
SN
Ho
D000818:Animals; D002455:Cell Division; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007477:Ions; D008954:Models, Biological; D050778:NFATC Transcription Factors; D009995:Osmosis; D010766:Phosphorylation; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D007477:Ions; D050778:NFATC Transcription Factors; D014157:Transcription Factors