Pharmacoproteomics in drug development.
The field of proteomics is taking on increased significance as the relevance of investigating and understanding protein expression in disease and drug development is appreciated. Recent advances in proteomics have been driven by the availability of numerous annotated whole-genome sequences and a broad range of technological and bioinformatic developments that underscore the complexity of the proteome. This review briefly addresses some of the various technologies that comprise Expression Proteomics and Functional Proteomics, citing examples where these emerging approaches have been applied to pharmacology, toxicology, and the development of drugs.
Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 1345 W 16th Street, Indianapolis, IN 46202, USA. fwitzmann@iupui.edu
Frank A
FA
Witzmann
Raymond A
RA
Grant
D000818:Animals; D015195:Drug Design; D006801:Humans; D015388:Organelles / Q000378:metabolism; D010597:Pharmacogenetics; D010601:Pharmacology, Clinical / Q000639:trends*; D014176:Protein Biosynthesis; D011506:Proteins / Q000737:chemistry / Q000235:genetics
D011506:Proteins