Serum level of the circulating angiogenesis inhibitor endostatin in patients with hyperthyroidism or hypothyroidism.
Serum level of endostatin, a natural angiogenesis inhibitor, was measured in 12 patients with hyperthyroidism and 9 patients with hypothyroidism. Control values were obtained from 12 healthy individuals. Hyperthyroidism was shown to be associated with an increased level of endostatin and hypothyroidism with a decreased endostatin level. There was no correlation of serum endostatin with thyroid hormone levels. Endostatin is a fragment of type XVIII collagen, and it is possible that reported changes are related to the effect of thyroid hormones on connective tissue metabolism.
Department of Internal Medicine and Rheumatology, Medical University of Silesia, Katowice, Poland. ekucharz@slam.katowice.pl
Eugene J
EJ
Kucharz
Anna
A
Kotulska
Magdalena
M
Kopeć
Barbara
B
Stawiarska-Pieta
Robert
R
Pieczyrak
D000328:Adult; D020533:Angiogenesis Inhibitors / Q000097:blood*; D003094:Collagen / Q000097:blood*; D043170:Collagen Type XVIII; D043169:Endostatins; D005260:Female; D006111:Graves Disease / Q000097:blood; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood*; D007037:Hypothyroidism / Q000097:blood*; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D012016:Reference Values; D013963:Thyroid Hormones / Q000097:blood
D020533:Angiogenesis Inhibitors; D043170:Collagen Type XVIII; D043169:Endostatins; D010446:Peptide Fragments; D013963:Thyroid Hormones; D003094:Collagen