Control of vesicular trafficking by Rho GTPases.
Although vesicular trafficking is essential for a large variety of cellular processes, the regulation of vesicular trafficking is still poorly understood. Members of the Rho family of small GTPases have recently emerged as important control elements of many stages of vesicular trafficking, providing new insight into the regulation of these events. We will discuss the diverse roles played by Rho proteins in membrane trafficking and focus on the biological implications of these functions.
Symons
Marc
M
Center for Oncology and Cell Biology, North Shore-LIJ Research Institute, 350 Community Dr., Manhasset, New York 11030, USA. msymons@nshs.edu
Rusk
Nicole
N
D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D002966:Clathrin / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology; D005089:Exocytosis / Q000502:physiology; D051275:Glucose Transporter Type 4; D006801:Humans; D009004:Monosaccharide Transport Proteins / Q000378:metabolism; D009124:Muscle Proteins; D021381:Protein Transport; D022161:Transport Vesicles / Q000502:physiology*; D020744:rac GTP-Binding Proteins / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology*
D002966:Clathrin; D051275:Glucose Transporter Type 4; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; C495692:SLC2A4 protein, human; C503256:RHOQ protein, human; D020744:rac GTP-Binding Proteins; D020741:rho GTP-Binding Proteins