Preparation of (188) Re-labeled paper for treating skin cancer.
For homogeneous delivery of beta radiation to skin cancer, we developed a simple method for preparing (188) Re-labeled nitrocellulose paper. The homogeneity and stability of the labeled paper were investigated. Absorbed dose estimates were calculated using the Monte-Carlo method. A 74-MBq (188) Re-labeled paper with 1-cm diameter delivered 147.2 Gy up to 1-mm depth after 2-h irradiation. Animal experiments on tumor-bearing mice showed that 50 Gy is an adequate dose for treating skin cancer. Tumors disappeared 7 days after irradiation in all the groups irradiated by 50 or 100 Gy. The (188) Re-labeled paper provided a convenient, economical, effective, and non-invasive method of treating skin cancer.
Jeong
Jae Min
JM
Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Lee
Yong Jin
YJ
Kim
Eun-Hee
EH
Chang
Young Soo
YS
Kim
Young Joo
YJ
Son
Miwon
M
Lee
Dong Soo
DS
Chung
June-Key
JK
Lee
Myung Chul
MC
D000818:Animals; D003101:Collodion / Q000008:administration & dosage / Q000737:chemistry*; D007553:Isotope Labeling; D051379:Mice; D008807:Mice, Inbred BALB C; D009010:Monte Carlo Method; D010209:Paper; D011829:Radiation Dosage; D011868:Radioisotopes / Q000008:administration & dosage / Q000737:chemistry*; D012211:Rhenium / Q000008:administration & dosage / Q000737:chemistry*; D012510:Sarcoma 180 / Q000532:radiotherapy; D012878:Skin Neoplasms / Q000532:radiotherapy*; D014407:Tumor Cells, Cultured
D011868:Radioisotopes; D012211:Rhenium; D003101:Collodion