Bone marrow findings in patients with adult Still's disease.
OBJECTIVE
Peripheral neutrophilia is one of characteristic laboratory findings in patients with adult Still's disease (ASD). We performed this study to identify the bone marrow findings in patients ASD.


METHODS
We examined 12 bone marrow biopsy specimens from patients with ASD.


RESULTS
The most frequent finding was granulocyte hyperplasia (12/12, 100%) and hypercellularity was observed in 75.0% (8/12) of patients. Plasmacytosis was present in 8.3% (1/12) of specimens. Histiocytosis and reactive hemophagocytosis were found in 25.0% (4/12) and in 16.7% (2/12) respectively.


CONCLUSIONS
Our results show that bone marrow granulocyte hyperplasia is the main possible mechanism for peripheral neutrophilia and that histiocytic activation is a not infrequent bone marrow findings in patients with ASD.
Min
Jun-Ki
JK
Holy Family Hospital, College of Medicine, The Catholic University of Korea, Kyunggi-Do, South Korea. min6403@netian.com
Cho
Chul-Soo
CS
Kim
Ho-Youn
HY
Oh
Eun-Ji
EJ
D000293:Adolescent; D000328:Adult; D001854:Bone Marrow Cells / Q000473:pathology*; D002452:Cell Count; D005260:Female; D015614:Histiocytosis / Q000209:etiology / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology; D010587:Phagocytosis; D010950:Plasma Cells / Q000473:pathology; D016706:Still's Disease, Adult-Onset / Q000150:complications / Q000473:pathology*