Primary biliary cirrhosis associated with HLA-DRw3.
Twenty-one unrelated Caucasian patients with Primary Biliary Cirrhosis were typed for HLA-A, B, C and HLA-DRw antigens. The antigens HLA-Al, HLA-B8 and HLA-DRw3 were found in increased frequency in relation to the control group. When the P values were corrected for the number of antigens tested only the increase of HLA-DRw3 remained significantly different from the control group (P crr. < 0.004). The antigen HLA-DRw3 was carried by 12 out of 21 patients (57.1%) in comparison to 11 out of 74 (14.8%) normal unrelated Caucasian subjects.
Department of Immunology, Liver Unit, Hospital Clínico y Provincial, Barcelona, Spain.
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G
Ercilla
A
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Parés
F
F
Arriaga
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M
Bruguera
R
R
Castillo
J
J
Rodés
J
J
Vives
D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015788:HLA-A1 Antigen / Q000032:analysis; D015795:HLA-B8 Antigen / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D015803:HLA-DR3 Antigen; D006521:Hepatitis, Chronic / Q000235:genetics / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D015810:Linkage Disequilibrium; D008105:Liver Cirrhosis, Biliary / Q000235:genetics / Q000276:immunology*; D008297:Male; D013030:Spain / Q000453:epidemiology; D044465:White People / Q000235:genetics
D015788:HLA-A1 Antigen; D015795:HLA-B8 Antigen; D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen