Long-term administration of Polygonum multiflorum Thunb. reduces cerebral ischemia-induced infarct volume in gerbils.
Focal cerebral ischemia was produced by an occlusion of the middle cerebral artery for 1, 3 and 24 hours in gerbils. Infarct volumes were determined by 2,3,5-triphenyltetrazolium chloride (TTC) transcardiac perfusion 24 hours after cerebral ischemia. Significant and consistent infarct sizes were produced in gerbils subjected to 24-hour occlusion of the middle cerebral arterey when compared to the 1 and 3-hour occlusion group. Longterm pretreatment of the 50% ethanol extract of Polygonum multiflorum Thunb. for 2 weeks significantly reduced the infarct volume by 50% as compared to that of the 24-hour occlusion group. The results revealed that long term pretreatment of Polygonum multiflorum Thunb. may protect the brain against focal cerebral ischemia.
Department of Nutrition, Providence University, Taichung, 433 Taiwan, ROC.
Yin-Ching
YC
Chan
Ming-Fu
MF
Wang
Ya-Ching
YC
Chen
Dar-Yu
DY
Yang
Ming-Shih
MS
Lee
Fu-Chou
FC
Cheng
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005849:Gerbillinae; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology; D008297:Male; D009043:Motor Activity / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018517:Plant Roots; D028502:Polygonum; D011897:Random Allocation; D013997:Time Factors
D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents