Proton MR spectroscopy in Wernicke encephalopathy.
Wernicke encephalopathy is caused by thiamine deficiency. Although the clinical picture has been well established for some time, clinical diagnosis is attained in only 20% of the cases. MR imaging techniques contribute to early diagnosis of Wernicke encephalopathy. We herein report MR imaging and proton MR spectroscopic findings for a patient with clinical and biochemical features consistent with Wernicke encephalopathy. Increased lactate and typical MR imaging findings are discussed in the context of the known pathophysiology of Wernicke encephalopathy.
Rugilo
Carlos A
CA
Servicio de Neurología, Buenos Aires, Argentina.
Uribe Roca
Marcela C
MC
Zurru
Maria C
MC
Capizzano
Arístides A
AA
Pontello
Gustavo A
GA
Gatto
Emilia M
EM
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D014899:Wernicke Encephalopathy / Q000175:diagnosis* / Q000378:metabolism
D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate