Monitoring vaccine safety during measles mass immunization campaigns: clinical and programmatic issues.
In the planning and implementation of mass immunization campaigns, vaccine delivery has always been a priority. However, safety issues have gained increasingly more attention and grown in importance, and campaign planners must now take them into prime consideration. The World Health Organization has released guidelines to assist with the design and implementation of safety surveillance systems, primarily for developing countries, and these include a new monograph for measles mass campaigns. Experience in the past decade with mass campaigns (primarily in developed countries) shows that measles vaccine performs in these settings as anticipated from pre- and post-licensure studies. Serious adverse events are rare, even under the increased scrutiny extended during a campaign. The experience in developing country settings is growing. The implementation of safety surveillance for mass campaigns offers a unique opportunity for countries to avoid crisis situations and to begin vaccine safety monitoring in routine immunization programs.
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. robert_pless@hc-sc.gc.ca
Robert P
RP
Pless
Adwoa D
AD
Bentsi-Enchill
Philippe
P
Duclos
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D017589:Immunization Programs / Q000379:methods* / Q000592:standards; D007223:Infant; D008457:Measles / Q000517:prevention & control*; D008458:Measles Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D012449:Safety / Q000592:standards; D014944:World Health Organization
D008458:Measles Vaccine