[Disinfection of gas-permeable contact lenses against prions].
Potential iatrogenic transmission from patients incubating Creutzfeldt-Jakob disease, especially variant CJD, is a major public health issue. Because the ocular route is very efficient for contamination with prions, re-use of rigid contact lenses in ophthalmology constitutes a potential problem. We therefore evaluated the anti-prion activity of different protocols available for disinfection of lenses. These treatments decreased the infectivity retained on the surface of experimentally contaminated lenses by a factor of at least 10 million. They thus represent an important factor in protecting against possible prion infection via the ocular route.
Comoy
E
E
Département de Recherche Médicale/Direction des Sciences du Vivant, CEA, Fontenay-aux-Roses Cedex. comoy@dsvidf.cea.fr
Bonnevalle
C
C
Métais
A
A
Auvré
F
F
Letessier
F
F
Lamoury
F
F
Spittler
J
J
Dormont
D
D
Deslys
J-P
JP
D000818:Animals; D003263:Contact Lenses, Hydrophilic; D006224:Cricetinae; D004203:Disinfection / Q000379:methods*; D005260:Female; D006801:Humans; D008647:Mesocricetus; D023421:Models, Animal; D010539:Permeability; D017096:Prion Diseases / Q000517:prevention & control* / Q000635:transmission; D011328:Prions / Q000302:isolation & purification / Q000472:pathogenicity*
D011328:Prions