[Physiopathology of inflammation].
The inflammatory reaction represents all the means associated with any aggression, and needed to maintain body integrity and survival. It acts first as a way to stimulate body surveillance and then as all the means to control any aggression. Such response largely non-specific of a specific cause, results from interactions between cells and soluble factors. The specificity of such response accounts for the anatomic localization of the disease. Among the many soluble factors, the proinflammatory cytokines tumour necrosis factor a and Interleukin-1 play a critical role, which has led to their therapeutic control with specific inhibitors. Positive clinical results have confirmed their biologic importance. However some side effects associated with the use of such inhibitors namely infections, have demonstrated the protective role of cytokines in stress survival.
Miossec
Pierre
P
Unité d'immunologie clinique Service de rhumatologie Hôpital Edouard Herriot 69437 Lyon. miossec@univ-lyon1.fr
D002908:Chronic Disease; D016207:Cytokines / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology
D016207:Cytokines