Phase-transfer alkylation reactions using microreactors.
Phase-transfer alkylation in a microreactor proceeds smoothly, and the reaction has been found to be more efficient than that in a round-bottomed flask with vigorous stirring; we have observed by an optical microscope study that an interfacial area provided by organic and aqueous phases is more extended in a microreactor.
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Masaharu
M
Ueno
Hideaki
H
Hisamoto
Takehiko
T
Kitamorib
Shŭ
S
Kobayashi