Extended-spectrum beta-lactamase enzymes in clinical isolates of Enterobacter species from Lagos, Nigeria.
Over a 9-month period, 8 of 40 nonduplicate isolates of Enterobacter spp. producing extended-spectrum beta-lactamase (ESBL) were detected for the first time from two hospitals in Lagos, Nigeria. Microbiologic and molecular analysis confirmed the presence of ESBL. Only four isolates transferred ESBL resistance as determined by the conjugation test, and pulsed-field gel electrophoresis showed genetically unrelated isolates.
Aibinu
I E
IE
Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, P.M.B 12003, Lagos, Nigeria. ibaibinu@yahoo.com
Ohaegbulam
V C
VC
Adenipekun
E A
EA
Ogunsola
F T
FT
Odugbemi
T O
TO
Mee
B J
BJ
D001483:Base Sequence; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D004754:Enterobacter / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D005798:Genes, Bacterial; D006801:Humans; D009549:Nigeria; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000378:metabolism*
D004269:DNA, Bacterial; D001618:beta-Lactamases