Vesicle-mediated restoration of a plasmalemmal barrier in severed axons.
Ca(2+)-induced endocytotic vesicles undergo protein-mediated interactions to restore a selectively permeable barrier and propagated action potentials in severed invertebrate giant axons. Similar barrier-restoration phenomena observed in cultured mammalian cells with transected neurites suggest that cellular/molecular mechanisms that repair plasmalemmal damage are phylogenetically conserved.
Fishman
Harvey M
HM
Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77555-0641, USA.
Bittner
George D
GD
D000818:Animals; D001369:Axons / Q000378:metabolism*; D019771:Axotomy; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D009416:Nerve Regeneration / Q000502:physiology*
D002118:Calcium