Seizure associated with sleep deprivation and sustained-release bupropion.
This case report describes a generalized seizure associated with sustained-release bupropion use and sleep deprivation. The subject, a 31-year-old female smoker, was participating in a clinical trial evaluating an investigational medication for smoking cessation that used sustained-release bupropion as an active control. After 5 weeks of bupropion use, the subject experienced a generalized tonic clonic seizure after staying up nearly all night packing and moving to a new residence. The patient had no other risk factors for seizures. We suggest that sleep deprivation may add to the risk of bupropion-associated seizures.
Department of Medicine and Obstetics and Gynecology, University of Connecticut School of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030-3940, USA. oncken@nso2.uchc.edu
Cheryl A
CA
Oncken
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RB
Duckrow
D000328:Adult; D016642:Bupropion / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012640:Seizures / Q000139:chemically induced / Q000209:etiology*; D012892:Sleep Deprivation / Q000150:complications*; D016540:Smoking Cessation / Q000379:methods*; D000074606:Smoking Prevention
D003692:Delayed-Action Preparations; D016642:Bupropion