Lipoxins and aspirin-triggered lipoxins in airway responses.
Here, we have demonstrated potent inhibition of allergen-mediated pulmonary inflammation and airway hyper-responsiveness by a novel dual-pronged action of LX's. Moreover, these results indicate that LX's play pivotal and previously unappreciated roles in regulating allergy and pulmonary inflammation.
Levy
Bruce D
BD
Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
De Sanctis
George T
GT
Devchand
Pallavi R
PR
Kim
Eugene
E
Ackerman
Kate
K
Schmidt
Birgitta
B
Szczeklik
Wojciech
W
Drazen
Jeffrey M
JM
Serhan
Charles N
CN
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology*; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D007962:Leukocytes / Q000378:metabolism; D044045:Lipoxins; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D044042:Receptors, Formyl Peptide; D044067:Receptors, Lipoxin
C105101:FPR2 protein, human; D006893:Hydroxyeicosatetraenoic Acids; D044045:Lipoxins; D011956:Receptors, Cell Surface; D044042:Receptors, Formyl Peptide; D044067:Receptors, Lipoxin; C040527:lipoxin A4; D001241:Aspirin