[Pathology of spastic muscles. Study of 26 patients].
Spastic hypertonia is observed in various central neurological diseases. Pathology of spastic muscle is not well known. Tibial selective microsurgical neurotomy is used for the spastic foot treatment. Twenty-six hemiplegic patients, spastic since more than one year, underwent selective tibial microsurgical neurotomy. Biopsies of soleus, lateral and medial gastrocnemius muscles were performed during surgical treatment, after free patient consent and ethical committee approval. The aim of this study was to describe histopathological lesions of spastic muscles, with histological and histoenzymatic techniques. Histological studies revealed myogenic atrophy, concerning both types of fibers or only type II fibers. They also showed type I (slow fibers) to type II (fast fibers) transformation, in the three studied muscles. These results are similar to those described in the literature.
Streichenberger
N
N
Service de Neuropathologie, Hôpital Neurologique, Lyon. nathalie.streichenberger@chu-lyon.fr
Mertens
P
P
D000293:Adolescent; D000328:Adult; D001284:Atrophy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000473:pathology; D009128:Muscle Spasticity / Q000473:pathology* / Q000601:surgery; D018482:Muscle, Skeletal / Q000473:pathology* / Q000601:surgery; D019635:Neurosurgical Procedures; D010291:Paresis / Q000473:pathology / Q000601:surgery