Islet transplantation, stem cells, and transfusion medicine.
Despite the widespread use of exogenous insulin, morbidity and mortality caused by type 1 diabetes mellitus (DM) continue to place a significant burden on society, both in terms of human suffering and cost. The transplantation of vascularized pancreas, usually performed concurrently with renal transplantation, can cure type 1 DM, as shown by results in more than 15000 such transplants over about 30 years. Transplantation of isolated pancreatic islets, instead of the whole organ, however, offers an attractive alternative that minimizes surgery and its complications. Although islet transplantation initially met with only modest success (only about 9% insulin independence at 1 year posttransplant), recent changes in patient selection criteria, number and treatment of islets transplanted, and better immunosuppressive regimens dramatically improved the results; spawning widespread enthusiasm for islet transplantation. Despite this promise, organ/islet availability remains an important limitation to this technology. A solution to the problem of limited materials for transplantation may be in the use of stem/progenitor cells. This article reviews the background of the current enthusiasm for pancreatic islet cell transplantation, highlights future research trends in the field, and suggests that the new islet-related cellular therapies belong within the domain of transfusion medicine.
Department of Pathology, The Carlos and Marguerite Mason Transplantation Biology Research Center, Emory University School of Medicine, Atlanta 30322, GA, USA. llogdbe@emory.edu
Lennart
L
Lögdberg
Stephen L
SL
Sgan
Christian P
CP
Larsen
Christopher D
CD
Hillyer
D018929:Cell Culture Techniques / Q000379:methods; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy*; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D007108:Immune Tolerance; D007515:Islets of Langerhans / Q000166:cytology / Q000276:immunology; D016381:Islets of Langerhans Transplantation / Q000379:methods* / Q000639:trends