[Effect of cytochrome oxidase inhibitors on the yeast thermotolerance].
The investigation of the effect of the cytochrome oxidase inhibitors sodium cyanide and sodium azide on the thermotolerance of the yeasts Rhodotorula rubra, Debaryomyces vanriji, and Saccharomyces cerevisiae showed that these inhibitors diminish the thermotolerance of R. rubra and D. vanriji, but do not affect the thermotolerance of S. cerevisiae. Taking into account the fact that, unlike the latter yeast, R. rubra and D. vanriji are nonfermentative yeasts, the difference in the effects of the inhibitors on the yeast thermotolerance can be readily explained by the different types of glucose utilization (either oxidative or fermentative) in these yeasts. The data obtained also provide evidence that there is a correlation between the functional activity of mitochondria and the thermotolerance of yeast cells.
Siberian Institute of Plant Physiology and Biochemistry, Siberian Division, Russian Academy of Sciences, ul. Lermontova 132, Irkutsk, 664033 Russia. eugene@sifibr.irk.ru
E G
EG
Rikhvanov
N N
NN
Varakina
T M
TM
Rusaleva
E I
EI
Rachenko
V K
VK
Voĭnikov
D000222:Adaptation, Physiological / Q000187:drug effects; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D018869:Heat-Shock Response / Q000187:drug effects; D006358:Hot Temperature; D012248:Rhodotorula / Q000187:drug effects / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000502:physiology; D019810:Sodium Azide / Q000494:pharmacology*; D012966:Sodium Cyanide / Q000494:pharmacology*; D013045:Species Specificity; D015003:Yeasts / Q000187:drug effects / Q000502:physiology*
D004791:Enzyme Inhibitors; D019810:Sodium Azide; D003576:Electron Transport Complex IV; D012966:Sodium Cyanide