Biochemical changes after subchronic and chronic interaction of Schistosoma mansoni infection in Swiss albino mice with two specific compounds.
In Egypt, infection with Schistosoma mansoni (S.m.) and residues of pesticides have been considered as major environmental pollutants that adversely affect health. Effects of diazinon (DZN) and/or praziquantel (PZQ) on the levels of plasma triiodothyronine (T3), thyroxine (T4), activities of brain acetylcholinesterase (AchE) and liver alanine aminotransferase (ALT) in addition to blood reduced glutathione (GSH) in healthy and S.m. infected mice were investigated after 9 and 17 weeks of either infection or intoxication with DZN. Triiodothyronine showed significant differences among the different treatments. The group of mice treated with PZQ showed the highest levels of T3 at both time intervals. Thyroxine level showed significant differences between the two time intervals. The lowest levels of T4 were observed in the infected-PZQ group at week 17. The maximum inhibition of brain AchE activity was noticed in DZN-PZQ treated group after 9 and 17 weeks. The different treatments significantly reduced the activities of liver ALT. The highest decrease was recorded in the infected-DZN-PZQ group at week 9. All treatments significantly lowered the levels of blood GSH after 9 weeks.
Department of Applied Biology, Radioisotope Application Division, Nuclear Research Center, Atomic Energy Authority, Faculty of Science, Ain Shams University, Cairo, Egypt.
Laila S
LS
Hanna
Amina M
AM
Medhat
Hanan A
HA
Abdel-Menem
D000110:Acetylcholinesterase / Q000378:metabolism; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology; D003976:Diazinon / Q000008:administration & dosage / Q000009:adverse effects*; D004347:Drug Interactions; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D011223:Praziquantel / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D012550:Schistosoma mansoni; D012555:Schistosomiasis mansoni / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D011223:Praziquantel; D000410:Alanine Transaminase; D000110:Acetylcholinesterase; D013974:Thyroxine; D003976:Diazinon