Actin's actions in LTP-induced synapse growth.
F-actin is required for LTP induction, but the underlying mechanisms are unclear. New results show that LTP produces an increase in actin-rich spines. Furthermore, these spines have large synapses, strongly suggesting that LTP involves synapse growth. This process appears to require LIMK-1 phosphorylation of the actin depolymerizing factor cofilin.
Biology Department, Brandeis University, Volen Center for Complex Systems, Waltham, MA 02454, USA.
John
J
Lisman
D000199:Actins / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002490:Central Nervous System / Q000254:growth & development* / Q000378:metabolism* / Q000648:ultrastructure; D004268:DNA-Binding Proteins / Q000378:metabolism; D003712:Dendrites / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D054461:Lim Kinases; D017774:Long-Term Potentiation / Q000502:physiology*; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D013569:Synapses / Q000378:metabolism* / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000502:physiology
D000199:Actins; D004268:DNA-Binding Proteins; D011494:Protein Kinases; C515892:LIMK1 protein, human; D054461:Lim Kinases; D017346:Protein Serine-Threonine Kinases