Interleukin-6 protects skin lesion caused by 7,12-dimethylbenz[a]anthracene.
Interleukin-6 (IL-6) regulates essential physiological functions such as acute phase reaction, immune response and hematopoiesis. We here studied possible protective effects of IL-6 on skin damage caused by 7,12-dimethylbenz[a]anthracene (DMBA) by using IL-6 null mice. The mice were topically applied with a single dose of DMBA (500 microg /mouse) on the dorsal skin. Osmotic pumps filled with recombinant human IL-6 (rhIL-6) were implanted subcutaneously on the ventral side of the mice. Control mice received PBS instead of rhIL-6 by the pump. Severe skin damage was observed in IL-6-null mice, whereas only epidermal hyperplasia was observed in the wild-type mice. Recombinant hIL-6 treatment to DMBA-treated IL-6-null mice suppressed the occurrence of the skin damage, indicating.
Environmental Health Sciences Division, National Institute for Environmental Studies, Onogawa, Tsukuba, Ibaraki, Japan.
Mie
M
Murata
Noriko
N
Nishimura
Baoxu
B
Zhang
Masahiko
M
Satoh
Chiharu
C
Tohyama
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D006801:Humans; D015850:Interleukin-6 / Q000494:pharmacology / Q000502:physiology*; D051379:Mice; D011994:Recombinant Proteins / Q000494:pharmacology; D012867:Skin / Q000187:drug effects* / Q000473:pathology
D002273:Carcinogens; D015850:Interleukin-6; D011994:Recombinant Proteins; D015127:9,10-Dimethyl-1,2-benzanthracene