Chemotropic molecules: guides for axonal pathfinding and cell migration during CNS development.
Different molecules (netrins, semaphorins, slits) with chemotropic functions and their receptors (neogenin, DCC, neuropilins, plexins, robos) have been identified that guide axons during development of the nervous system to establish the complex pattern of connections among a large number of neurons. These molecules have been recently identified to play a role in cell migration of the central nervous system during development.
de Castro
Fernando
F
Neurobiología-Investigación, Hospital Ramón y Cajal, Madrid-28034, Spain.
D000818:Animals; D001369:Axons / Q000502:physiology*; D002490:Central Nervous System / Q000196:embryology*; D029721:Drosophila Proteins; D004622:Embryo, Mammalian / Q000502:physiology; D004625:Embryo, Nonmammalian / Q000502:physiology; D005314:Embryonic and Fetal Development; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D039961:Semaphorins / Q000502:physiology*
D029721:Drosophila Proteins; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D039961:Semaphorins; C066819:sli protein, Drosophila