Preliminary study on reducing oral moist snuff use.
BACKGROUND
Tobacco exposure reduction may be an alternative treatment approach for those tobacco users who are unwilling or unable to quit tobacco use. However, very little information is available on the feasibility of this type of intervention, especially in the area of oral moist snuff tobacco (ST). This pilot study examined whether reducing ST use using various methods can be achieved and whether this reduction results in lower exposure to carcinogens.


METHODS
Moist snuff users (N=40 males) were randomly assigned to 4 mg nicotine gum, non-tobacco mint snuff, brand switching, or elimination of ST use in specific situations. These approaches were used to reduce ST use or nicotine exposure by at least 25% for the first 2 weeks and 50% the subsequent 6 weeks of treatment. Follow-up sessions occurred at 12 and 26 weeks.


RESULTS
Significant reductions were observed in tins per week and cotinine levels across all conditions. Among the intent-to-treat population, the abstinence rate was 15% at 26 weeks. Reduction in nicotine exposure was associated with reduction in exposure to nitrosamines.


CONCLUSIONS
Reduction in ST use may be a viable approach for those oral moist ST users with no immediate quit plans. Future research in this area is needed.
Hatsukami
Dorothy K
DK
University of Minnesota, Tobacco Use Research Center, 2701 University Ave SE, #210, Minneapolis 55414, USA. hatsu001@umn.edu
Edmonds
Amanda
A
Schulte
Susan
S
Jensen
Joni
J
Le
Chap T
CT
Losey
London
L
Carmella
Steven G
SG
Hecht
Stephen S
SS
D000284:Administration, Oral; D000328:Adult; D002638:Chewing Gum; D006801:Humans; D016014:Linear Models; D008297:Male; D009538:Nicotine / Q000627:therapeutic use*; D010865:Pilot Projects; D019966:Substance-Related Disorders / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D014030:Tobacco, Smokeless / Q000494:pharmacology
D002638:Chewing Gum; D009538:Nicotine