Synthesis and immunosuppressive activity of novel succinylacetone analogues.
This study describes the synthesis of novel enol esters (3) and triketones (4) as analogues of succinylacetone (SA) (Ed- this abbreviation is introduced here based on your use of it in the body of the paper) and the evaluation on the mouse allogeneic mixed lymphocyte reaction (MLR) and the murine model of antigen-induced paw edema formation for immunosuppressive activity. Enol esters (3a-f) were about 2-4 fold more potent than SA in in vitro activity.
Kim
Taek Hyeon
TH
Department of Applied Chemistry, College of Engineering, Chonnam National University, Gwangju 500-757, Korea. thkim@chonnam.ac.kr
Oh
Dong Ryun
DR
Na
Hee Sam
HS
Lee
Hyun Chul
HC
D000818:Animals; D004487:Edema / Q000188:drug therapy / Q000276:immunology; D006537:Heptanoates / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D006537:Heptanoates; D007166:Immunosuppressive Agents; C020804:succinylacetone