Ras proteins: different signals from different locations.
Ras signalling has classically been thought to occur exclusively at the inner surface of a relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact dynamically with specific microdomains of the plasma membrane as well as with other internal cell membranes. These different membrane microenvironments modulate Ras signal output and highlight the complex interplay between Ras location and function.
Hancock
John F
JF
Institute for Molecular Bioscience and Department of Molecular and Cellular Pathology, University of Queensland, Brisbane, Australia 4072. j.hancock@mailbox.uq.edu.au
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D017124:Conserved Sequence; D004721:Endoplasmic Reticulum / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D018631:ras Proteins / Q000737:chemistry / Q000378:metabolism*
D008565:Membrane Proteins; D019204:GTP-Binding Proteins; D018631:ras Proteins