Pharmacokinetics of BNP7787 and its metabolite mesna in plasma and ascites: a case report.
OBJECTIVE
BNP7787 (2',2'-dithio-bis-ethane sulfonate sodium) is a novel protector against cisplatin-induced toxicities. The pharmacokinetics of BNP7787 and its metabolite mesna were investigated in plasma and ascites of a cancer patient. We also evaluated potential pharmacokinetic interactions between BNP7787 and cisplatin.


METHODS
BNP7787 and mesna were measured as mesna in deproteinized plasma and ascites using high-performance liquid chromatography with an electrochemical detector provided with a wall-jet gold electrode.


RESULTS
After the i.v. administration of 41 g/m(2) BNP7787, BNP7787 and mesna had a half-life of 1.5 and 3.4 h, respectively. The AUC( infinity ) of mesna was approximately 8% of the AUC( infinity ) of BNP7787. Coadministration of cisplatin did not appear to influence the plasma concentration-time curves of BNP7787 and mesna. In ascites, approximately 0.02% of the BNP7787 dose was present as mesna, whereas approximately 4% of the dose was present as BNP7787 at the time of the maximum concentration.


CONCLUSIONS
It can be concluded that the presence of ascites did not have a major impact on the pharmacokinetics of BNP7787 and coadministration of cisplatin did not influence the pharmacokinetics of BNP7787 and mesna.
Department of Medical Oncology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands. M.Verschraagen@vumc.nl
Miranda
M
Verschraagen
Epie
E
Boven
Ivon
I
Zegers
Frederick H
FH
Hausheer
Wim J F
WJ
Van der Vijgh
D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology; D019540:Area Under Curve; D001201:Ascites / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002945:Cisplatin / Q000494:pharmacology; D004563:Electrochemistry; D006207:Half-Life; D006801:Humans; D008297:Male; D015080:Mesna / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*
D000970:Antineoplastic Agents; C027032:2,2'-dithiodiethanesulfonic acid; D015080:Mesna; D002945:Cisplatin