Membrane Na+-K+ ATPase inhibition mediated quantal model for brain evolution.
The hypothalamus secretes an endogenous membrane Na+-K+ ATPase inhibitor, digoxin. A digoxin-mediated model of quantal perception is proposed. In the quantal state, self replication of self-organized macromolecules is possible. This leads to the origin of molecular organisms like prions. Macromolecules group together to form organelle, which in evolutionary terms are independent bacteria. The organelle/bacteria symbiotically cluster together to form the cell. The human organism, including the brain, can be visualized as an organized cluster or colony of unicellular, symbiotically grouped flagellated bacteria. Synaptic connections form in the bacterial cluster leading to the evolution of the primitive neuronal networks, and later the human brain. The role of quantal perception and the observer function of consciousness in the origin of matter is important. Symbiotically clustered intergalactic magnetotactic bacterial networks are important in the evolution of the universe.
Department of Neurology, Medical College Hospital, Trivandrum, Kerala, India.
Ravi Kumar
RK
Kurup
Parameswara Achutha
PA
Kurup
D005075:Biological Evolution; D001921:Brain / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism*; D003243:Consciousness / Q000502:physiology; D006801:Humans; D007031:Hypothalamus / Q000166:cytology* / Q000378:metabolism*; D010042:Ouabain / Q000378:metabolism*; D013360:Subliminal Stimulation
C083016:sodium-potassium ATPase inhibitory factor; D010042:Ouabain