AMPA receptor trafficking and long-term potentiation.
Activity-dependent changes in synaptic function are believed to underlie the formation of memories. A prominent example is long-term potentiation (LTP), whose mechanisms have been the subject of considerable scrutiny over the past few decades. I review studies from our laboratory that support a critical role for AMPA receptor trafficking in LTP and experience-dependent plasticity.
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. malinow@cshl.org
Roberto
R
Malinow
D000818:Animals; D004594:Electrophysiology; D006706:Homeostasis; D017774:Long-Term Potentiation / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D010766:Phosphorylation; D018091:Receptors, AMPA / Q000502:physiology*; D011994:Recombinant Proteins / Q000378:metabolism; D013569:Synapses / Q000502:physiology
D018091:Receptors, AMPA; D011994:Recombinant Proteins