High-dose methylprednisolone treatment of hepatic veno-occlusive disease in a child with Wilms tumor.
Veno-occlusive disease (VOD) is a rare complication of chemotherapy in children with cancer. In the literature successful treatment of severe VOD has not been well determined. The authors report a 5-year-old boy with Willms tumor whose condition was complicated with VOD while receiving chemotherapy. He was treated successfully with high-dose methylprednisolone. After therapy, the clinical signs of VOD, such as abdominal ascites, oliguria, and jaundice, disappeared without any adverse effects of therapy.
Akyüz
Canan
C
Department of Pediatric Oncology, Hacettepe University, Institute of Oncology, Ankara, Turkey. cakyuz@hacettepe.edu.tr
CaClar
Kudret
K
Emir
Suna
S
Büyükpamukçu
Münevver
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002675:Child, Preschool; D005938:Glucocorticoids / Q000008:administration & dosage*; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D009396:Wilms Tumor / Q000188:drug therapy / Q000473:pathology*
D005938:Glucocorticoids; D008775:Methylprednisolone