Castleman's disease associated with myasthenia gravis.
Castleman's disease presents as a peculiar type of lymph node hyperplasia. Traditionally, the disease has been classified on clinical grounds (solitary or multicentric) and by histologic appearance (hyaline vascular pattern, plasma cell predominance, or mixed lesions). It is now increasingly clear that there are different etiologies for each of these different subtypes. Reported associations include POEMS syndrome (polyneuropathy, organomegally, endocrinopathy, monoclonal gammopathy, and skin changes), paraneoplastic pemphigus, Hodgkin's disease, and follicular dendritic cell sarcoma. We present a case of Castleman's disease associated with myasthenia gravis, the third reported case in the literature. We discuss Castleman's disease and review the literature.
Department of Cardiothoracic Surgery, Hammersmith Hospital, London, United Kingdom. j.day@ic.ac.uk
Jonathan R S
JR
Day
Duncan
D
Bew
Mark
M
Ali
Roberto
R
Dina
Peter L C
PL
Smith
D000328:Adult; D005871:Castleman Disease / Q000150:complications* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D009157:Myasthenia Gravis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D013950:Thymus Gland / Q000473:pathology