Immune-mediated clearance of virus from the central nervous system.
Immune-mediated clearance of virus from the central nervous system (CNS) differs from that of the other organs. Mechanisms of virus control are largely dependent upon the target cell type. Although cytolytic T lymphocytes may mediate clearance of virus from glial cells, non-cytolytic mechanisms mediated by antibody and cytokines dominate clearance from neurons.
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.
Gwendolyn K
GK
Binder
Diane E
DE
Griffin
D000818:Animals; D020805:Central Nervous System Viral Diseases / Q000276:immunology* / Q000821:virology*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009457:Neuroglia / Q000276:immunology / Q000821:virology*; D009474:Neurons / Q000276:immunology / Q000821:virology*; D051381:Rats; D014779:Virus Replication; D014780:Viruses / Q000254:growth & development / Q000276:immunology*