Microbial viability in preparations packaged for single use.
We evaluated microbial viability in preparations packaged for single use only which mandate that residual solution be discarded such as albumin and globulin preparations as blood products, preparations containing albumin (such as urokinase and interferon), fat emulsions, and a preparation containing fat emulsions (propofol). In most preparations, Serratia marcescens and Burkholderia cepacia proliferated rapidly at 30 degrees C. However, in globulin preparations containing 1-2.25% glycine to prevent protein degradation (Gamma-Venin P, Venilon-I, Globulin Injection, and Ahlbulin), no growth of S. marcescens and B. cepacia was detected over 24 h at 30 degrees C. For globulin preparations containing 1-2.25% glycine, the injunction to "Discard residual solution after the package has been used" in the package inserts can be revised to "It is possible to use residual solution within 24 h after the package has been used with storage in a cool place."
Department of Pharmacy, Yamaguchi University Hospital, Minamikogushi, Ube, Japan.
Akiko
A
Obayashi
Shigeharu
S
Oie
Akira
A
Kamiya
D001419:Bacteria / Q000254:growth & development*; D016956:Burkholderia cepacia / Q000254:growth & development; D002176:Candida albicans / Q000254:growth & development; D015169:Colony Count, Microbial; D004340:Drug Contamination; D004349:Drug Packaging; D006863:Hydrogen-Ion Concentration; D009994:Osmolar Concentration; D019999:Pharmaceutical Solutions; D011550:Pseudomonas aeruginosa / Q000254:growth & development; D012706:Serratia marcescens / Q000254:growth & development; D013211:Staphylococcus aureus / Q000254:growth & development; D013997:Time Factors
D019999:Pharmaceutical Solutions