[Increasing drug resistance in Vibrio cholerae O1 and non-O1 strains isolated from diarrheal cases in Japan].
Drug resistance trends were investigated for 271 Vibrio cholerae O1 (V.c O1) and 401 V. cholerae non-O1 (V.c non-O1) strains isolated from mainly imported diarrheal cases during 1981-2001 in Japan. The results of drug resistance test using 8 drugs (CP, TC, SM, KM, ABPC, ST, NA, and NFLX) showed that 34.7% of the V. c O1 strains and 15.7% of V.c non-O1 strains were multi-drug or mono-drug resistant. The incidence of drug resistant strains has increased since 1991, and it has been remarkable in V.c O1 strains that increased from 1.2% in 1981-1985 to 70.8% in 1996-2001. The drug resistance patterns of the resistant strains classified into 6 types in V.c O1 and 21 types in V.c non-O1. The prevalent patterns recognized were SM (75.5%), CP.TC.SM.ST (10.6%) and CP.SM.ST (8.5%) in V.c O1, and SM (25.4%) and ABPC (25.4%) in V.c non-O1. Ten V.c O1 strains (3.7%) and 10 V.c non-O1 strains (2.5%) were multi-drug resistant including TC. Among those, 13 strains were isolated from travelers who returned to Japan from Thailand. One V.c O1 strain (0.4%) and 6 V.c non-O1 strains (1.5%) were NA high-resistant and fluoroquinolones low-sensitive. Among those, 4 strains were isolated from travelers who returned to Japan from India.
Tokyo Metropolitan Research Laboratory of Public Health.
Shigeru
S
Matsushita
Maho
M
Kawamura
Noriko
N
Konishi
Akemi
A
Kai
Rei
R
Katoh
Kazue
K
Ogata
Tadahiko
T
Itoh
Kazuyoshi
K
Yano
Koji
K
Morita
Noboru
N
Watanabe
Masato
M
Kanamori
Yasuo
Y
Kudoh
D003967:Diarrhea / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D013752:Tetracycline / Q000494:pharmacology*; D013753:Tetracycline Resistance; D014195:Travel; D014734:Vibrio cholerae / Q000187:drug effects* / Q000302:isolation & purification; D041241:Vibrio cholerae O1 / Q000187:drug effects* / Q000302:isolation & purification
D024841:Fluoroquinolones; D013752:Tetracycline