Tumour-cell invasion and migration: diversity and escape mechanisms.
Cancer cells possess a broad spectrum of migration and invasion mechanisms. These include both individual and collective cell-migration strategies. Cancer therapeutics that are designed to target adhesion receptors or proteases have not proven to be effective in slowing tumour progression in clinical trials--this might be due to the fact that cancer cells can modify their migration mechanisms in response to different conditions. Learning more about the cellular and molecular basis of these different migration/invasion programmes will help us to understand how cancer cells disseminate and lead to new treatment strategies.
Friedl
Peter
P
Department of Dermatology, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.
Wolf
Katarina
K
D000818:Animals; D002465:Cell Movement; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000473:pathology*