D1 and NMDA receptors hook up: expanding on an emerging theme.
In the dominant paradigm for functional interactions between G-protein-coupled receptors (GPCRs) and ligand-gated ion channels, the mantra is that the interactions are indirect, indirect, indirect. It is commonly understood that activating GPCRs engages one or more sets of intracellular signaling cascades that indirectly affect the function or localization of a cohort of ligand-gated ion channels. Conversely, stimulating ligand-gated channels, particularly those that are permeable to Ca(2+), indirectly produces effects on GPCRs and/or on GPCR-activated signaling cascades. The foundation of this dichotomous world-view shook (just a little) when it was discovered that D5 dopamine receptors bind directly to GABA(A) receptors, and that this direct interaction reciprocally affects the signaling of both types of receptor. Now, D1 dopamine receptors also have got into the act!
Programme in Brain and Behaviour, Hospital for Sick Children, and Department of Physiology, University of Toronto, Toronto, Canada M5G 1X8. mike.salter@utoronto.ca
Michael W
MW
Salter
D000818:Animals; D004298:Dopamine / Q000502:physiology; D019204:GTP-Binding Proteins; D007473:Ion Channels / Q000502:physiology; D020239:Receptor Cross-Talk / Q000502:physiology*; D017447:Receptors, Dopamine D1 / Q000502:physiology*; D050641:Receptors, Dopamine D5; D011963:Receptors, GABA-A / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*
D007473:Ion Channels; D017447:Receptors, Dopamine D1; D011963:Receptors, GABA-A; D016194:Receptors, N-Methyl-D-Aspartate; D050641:Receptors, Dopamine D5; D019204:GTP-Binding Proteins; D004298:Dopamine