Facile synthesis of [11C]edrophonium and its analogues as new potential PET imaging agents for heart acetylcholinesterase.
[11C]Edrophonium and its analogues have been synthesized for evaluation as new potential positron emission tomography (PET) imaging agents for heart acetylcholinesterase. The tracers were prepared by N-[11C]methylation of precursors using [11C]methyl triflate and isolated by solid-phase extraction (SPE) purification procedure in 50-65% radiochemical yields.
Department of Radiology, Indiana University School of Medicine, 975 West Walnut Street, Room 028C, Indianapolis 46202-5121, USA. qzheng@iupui.edu
Qi-Huang
QH
Zheng
Xuan
X
Liu
Xiangshu
X
Fei
Ji-Quan
JQ
Wang
Bruce H
BH
Mock
Barbara E
BE
Glick-Wilson
Michael L
ML
Sullivan
Gary D
GD
Hutchins
D002250:Carbon Radioisotopes; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis; D004491:Edrophonium / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D004867:Equipment Design; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D014055:Tomography, Emission-Computed / Q000379:methods*
D002250:Carbon Radioisotopes; D002800:Cholinesterase Inhibitors; D019275:Radiopharmaceuticals; D004491:Edrophonium