Lipoprotein lipase gene polymorphisms in Croatian patients with coronary artery disease.
Modifications in lipoprotein lipase levels lead to elevated triglycerides and reduced high density lipoprotein (HDL), both of which are risk factors for coronary artery disease (CAD). Hence, we examined the influence of the -93T/G, D9N, N291S, and S447X polymorphisms in the lipoprotein lipase (LPL) gene on CAD risk and lipid levels in Croatian patients with and without angiographically confirmed CAD. The N291S polymorphism was significantly associated with CAD (OR = 0.36; 95% CI = 0.13, 0.99; p = 0.048). This association was only moderately affected by adjusting for various lipids (OR = 0.36; 95% CI = 0.12, 1.08; p = 0.068). HDL2-cholesterol and apolipoprotein A-I levels were significantly higher in non-carriers of the -93T/G and D9N polymorphisms in the CAD group (p = 0.017 and 0.028, respectively). The N291S genetic variant did not show any significant difference between carriers and non-carriers in either group studied for any of the lipids. Lower triglyceride and higher HDL2-cholesterol levels in the control group were associated with carriers of the S447X mutation (p = 0.043 and 0.056, respectively). LPL gene polymorphisms might be involved in predisposition to CAD and determination of lipid profiles.
Ferencak
Goran
G
Clinical Institute of Laboratory Diagnosis, Clinical Hospital Center and Zagreb University School of Medicine, Zagreb, Croatia. gferen@mef.hr
Pasalić
Daria
D
Grsković
Branka
B
Cheng
Suzanne
S
Fijal
Bonnie
B
Sesto
Mihajlo
M
Skodlar
Jasna
J
Rukavina
Ana Stavljenić
AS
D000483:Alleles; D016632:Apolipoprotein A-I / Q000097:blood / Q000235:genetics; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D003324:Coronary Artery Disease / Q000097:blood / Q000201:enzymology* / Q000235:genetics*; D017523:Croatia; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood / Q000235:genetics
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides; D008071:Lipoprotein Lipase