Bioactive molecules and the future of pulp therapy.
Direct capping of bioactive molecules or implantation of these molecules in the pulp may induce the formation of reparative dentin and coronal or radicular pulp mineralization. In this review, we summarize what is known and/or assumed on the biological mechanisms of these therapies. We report on the effects which were obtained experimentally in rat maxillary molars by implantation of Bone Sialoprotein (BSP)/collagen pellets and Specific Amelogenin Gene Splice Products [A+4] and [A-4]) adsorbed on agarose beads. The effects were compared with those of BMP-7 (OP-1) and Ca(OH)2. Depending on the molecule that was used, we obtained either the formation of a dentin bridge, or the filling of the pulp in the mesial part of the coronal pulp chamber, or the total mineralization of the root canal. These molecules may provide new therapeutic tools in the next future in dentistry.
Faculté de Chirurgie Dentaire, Université Paris V, Montrouge, France. mgoldod@aol.com
Michel
M
Goldberg
Ngampis
N
Six
Frank
F
Decup
Jean-Jacques
JJ
Lasfargues
Erdjan
E
Salih
Kevin
K
Tompkins
Arthur
A
Veis
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology* / Q000627:therapeutic use; D002126:Calcium Hydroxide / Q000378:metabolism; D003738:Dental Cements / Q000378:metabolism; D003782:Dental Pulp / Q000166:cytology / Q000187:drug effects / Q000254:growth & development; D003785:Dental Pulp Capping / Q000379:methods* / Q000639:trends*; D003789:Dental Pulp Exposure / Q000628:therapy*; D003804:Dentin / Q000187:drug effects / Q000378:metabolism; D003809:Dentin, Secondary / Q000187:drug effects / Q000378:metabolism*; D005544:Forecasting; D008422:Materials Testing; D009804:Odontoblasts / Q000502:physiology; D051381:Rats; D013234:Stem Cells / Q000502:physiology
D001672:Biocompatible Materials; D003738:Dental Cements; D002126:Calcium Hydroxide