Regulation of membrane transport by rab GTPases.
Membrane flow through the cell is a highly dynamic process in which intracellular compartments communicate via tubulo-vesicular structures shuttling cargo molecules to their destinations. Transport carriers are formed at a donor compartment and navigate through the cytoplasm to the target organelle, on which they subsequently dock and fuse. Many of these events are regulated by the cooperative action of monomeric rab GTPases and their effector proteins. Research in recent years resulted in the identification of many rab effectors, providing first glimpses how the GTPase switch of individual rab proteins is utilized in discrete transport steps.
Deneka
Magdalena
M
Department of Cell Biology, Institute of Biomembranes, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
Neeft
Maaike
M
van der Sluijs
Peter
P
D000595:Amino Acid Sequence; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D020690:GTPase-Activating Proteins / Q000378:metabolism; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D015398:Signal Transduction / Q000502:physiology; D022161:Transport Vesicles / Q000502:physiology; D020691:rab GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; D026901:Membrane Transport Proteins; D020691:rab GTP-Binding Proteins