Building blocks for polyamide nucleic acids: facile synthesis using potassium fluoride doped natural phosphate as basic catalyst.
Potassium fluoride doped natural phosphate, inexpensive and environmentally friendly catalyst, is shown to be an efficient basic catalyst for the N1/N9 alkylation of different nucleobases as synthons for PNAs.
Laboratoire de Chimie Bioorganique, Faculté des Sciences Semlalia, Universite Cadi Ayyad, Marrakech, Maroc.
A
A
Alahiane
M
M
Taourirte
A
A
Rochdi
N
N
Redwane
S
S
Sebti
J W
JW
Engels
H B
HB
Lazrek
D000478:Alkylation; D002384:Catalysis; D005459:Fluorides / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis*; D010710:Phosphates / Q000737:chemistry; D017680:Potassium Compounds / Q000737:chemistry
D006571:Heterocyclic Compounds; D020135:Peptide Nucleic Acids; D010710:Phosphates; D017680:Potassium Compounds; C033320:potassium fluoride; D005459:Fluorides