IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
A family of proteins known as IQGAPs have been identified in yeast, amebas and mammals. IQGAPs are multidomain molecules that contain several protein-interacting motifs which mediate binding to target proteins. Mammalian IQGAP1 is a component of signaling networks that are integral to maintaining cytoskeletal architecture and cell-cell adhesion. Published data suggest that IQGAP1 is a scaffolding protein that modulates cross-talk among diverse pathways in complex regulatory circuits. These pathways include modulating the actin cytoskeleton, mediating signaling by Rho family GTPases and calmodulin, regulating E-cadherin and beta-catenin function and organizing microtubules.
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Thorn 530, 75 Francis Street, Boston, MA 02115, USA.
Michael W
MW
Briggs
David B
DB
Sacks
D000818:Animals; D020013:Calcium Signaling; D002147:Calmodulin / Q000502:physiology; D002352:Carrier Proteins / Q000737:chemistry / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D020764:cdc42 GTP-Binding Protein / Q000502:physiology; D020703:ras GTPase-Activating Proteins
D002147:Calmodulin; D002352:Carrier Proteins; C101203:IQ motif containing GTPase activating protein 1; D020703:ras GTPase-Activating Proteins; D020764:cdc42 GTP-Binding Protein