Serum androgen markers in preeclampsia.
OBJECTIVE
To determine whether maternal serum levels of androgens are associated with preeclampsia in primigravid women.


METHODS
A case-control study of primigravid women with singleton pregnancies. Women diagnosed with preeclampsia (n = 15) were matched with normotensive controls (n = 30) for age and gestational age. Serum testosterone, sex hormone binding globulin, estradiol and dehydroepiandrosterone sulfate were measured before delivery. The study had 80% power to detect a 30% difference in mean testosterone concentration between cases and controls using a two-tailed test and alpha level of .05. The Student t test, Mann-Whitney U test, Wilcoxon signed ranks test and chi 2 analysis of proportions were used for analysis.


RESULTS
Cases and controls did not differ in maternal age, gestational age, body mass index, tobacco use or neonatal sex. As compared with normotensive controls, preeclamptic women exhibited no statistically significant differences in median levels of total testosterone, free androgen index, sex hormone binding globulin, estradiol or dehydroepiandrosterone sulfate.


CONCLUSIONS
Maternal serum levels of androgens do not exhibit an association with preeclampsia in primigravid women.
Miller
Nora R
NR
Department of Obstetrics and Gynecology, Winthrop University Hospital, Mineola, New York, USA.
Garry
David
D
Cohen
Hillel W
HW
Figueroa
Reinaldo
R
D000328:Adult; D000728:Androgens / Q000032:analysis / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015331:Cohort Studies; D019314:Dehydroepiandrosterone Sulfate / Q000032:analysis / Q000097:blood; D004958:Estradiol / Q000032:analysis / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D010298:Parity; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012016:Reference Values; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D018709:Statistics, Nonparametric; D013739:Testosterone / Q000032:analysis / Q000097:blood
D000728:Androgens; D015415:Biomarkers; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate