[Lymphocyte subpopulation, interleukin-2 and high affinity interleukin-2 receptor expression in primary nephrotic syndrome].
OBJECTIVE
To understand the cellular immune response during relapse and remission stage in primary nephrotic syndrome (PNS).


METHODS
We applied the radioligand binding assay (RBA), the bioactivity measurement of IL-2, and monoclonal antibody sensitized red blood cell method to evaluate the expression of IL-2R, the production of IL-2 and T lymphocyte subsets of PBMC from 22 patients suffering from PNS, 17 patients with PNS in remission, and 25 normal subjects matched age and sex.


RESULTS
CD3, CD4, CD8, IL-2, IL-2R in relapse were significantly lower than those in control (P < 0.05); all above except CD8 in remission patients were significantly higher than those in relapse, but lower than those in control (P < 0.05).


CONCLUSIONS
This study suggested that the cell mediated immunity (CMI) during acute nephrotic phase decreased; the deficiency of CMI of PNS in remission improved a lot when compared with the acute phase, but still not recovered completely; the deficiency of CMI with PNS in remission might be one of the causes of easily recurring of PNS.
Department of Nephrology, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
P
P
Fu
G
G
Xu
S
S
Huang
T
T
Yu
D000328:Adult; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000276:immunology; D008297:Male; D009404:Nephrotic Syndrome / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis* / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D007376:Interleukin-2; D015375:Receptors, Interleukin-2