Synthesis and cytotoxic activity of 1,3-benzodioxole derivatives. Note II.
A series of 1,3-benzodioxoles (2-12) were synthesized and evaluated for their in vitro ability to inhibit the growth of three human tumor cell lines. No cytotoxic effects were noticed with any of the test compounds at a concentration of 10(-4) M.
Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, Messina 98168, Italy. nmicale@pharma.unime.it
Nicola
N
Micale
Maria
M
Zappalà
Silvana
S
Grasso
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004149:Dioxoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D004149:Dioxoles; C040539:1,3-benzodioxole