[Immune activation in AIDS related Kaposi's sarcoma].
To study the pathogenesis role of immune system activation in AIDS related Kaposi's sarcoma(AIDS-KS).



The serum levels of sFas, beta 2-microglobin, IL-10, IL-16, IL-18, IL-6 and sIL-4R were detected by ELISA in 8 AIDS-KS patients, 28 patients with HIV infection but without Kaposi's sarcoma(HIV-NKS) and 16 normal controls. The lymphocyte and their subsets, CD38(+) CD8, HLA-DR(+)CD8 in the peripheral blood mononuclear cell (PBMCs) in 12 AIDS-KS and 32 HIV-NKS were detected by flow cytometer.



Beta 2-MG and sIL-4R in HIV-NKS were significantly higher than those in normal controls(P<0.05), IL-16 in HIV-NKS was significantly lower than that in controls(P<0.05). IL-18 was higher in both AIDS-KS and HIV-NKS compared with normal controls. In AIDS-KS, CD3, CD4, CD8, NK and HLA-DR(+)CD8 were lower than those in HIV-NKS whereas CD19 and CD38(+)CD8 were higher than those in HIV-NKS. But the difference was not statistically(P<0.05).



Although both AIDS-KS and HIV-NKS demonstrate some activation of immune system, there appears to be no significant difference between immune responses in KS and NKS patients. These data suggest that the activation of the immune system is unlikely to contribute significantly to the pathogenesis of AIDS-KS.
The Institute of Infectious Disease, The First Affiliated Hospital, College of Medical Sciences, Zhejiang Univesity, Hangzhou 310003, China.
Biao
B
Zhu
Nan-ping
NP
Wu
Stefan
S
Hoxtermann
Armin
A
Bader
Norbert
N
Brockmeyer
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology*; D016207:Cytokines / Q000097:blood; D006684:HLA-DR Antigens / Q000097:blood; D006801:Humans; D019410:Interleukin-16 / Q000097:blood; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000276:immunology*
D016207:Cytokines; D006684:HLA-DR Antigens; D019410:Interleukin-16