Protecting against cocaine, heroin, and sarin gas.
The first X-ray structure of human carboxylesterase 1 (hCE1) and the structures of hCE1 with drug analogs bound reveal important molecular details of how the drugs cocaine, heroin, and tacrine are metabolized and cleared.
Syrrx, Inc., 10410 Science Center Drive, San Diego, CA 92121, USA.
Duncan
D
McRee
D001711:Biotransformation; D043182:Carboxylesterase / Q000737:chemistry* / Q000378:metabolism*; D002619:Chemical Warfare Agents / Q000378:metabolism* / Q000506:poisoning; D003042:Cocaine / Q000378:metabolism* / Q000506:poisoning; D062787:Drug Overdose / Q000188:drug therapy; D003932:Heroin / Q000378:metabolism* / Q000506:poisoning; D006801:Humans; D008958:Models, Molecular; D009294:Narcotics / Q000378:metabolism* / Q000506:poisoning; D011485:Protein Binding; D012524:Sarin / Q000378:metabolism* / Q000506:poisoning
D002619:Chemical Warfare Agents; D009294:Narcotics; D003932:Heroin; D012524:Sarin; D043182:Carboxylesterase; D003042:Cocaine