Helicobacter pylori infection and the risk for open-angle glaucoma.
OBJECTIVE
To determine the frequency of exposure to Helicobacter pylori infection in glaucoma patients.


METHODS
Prospective case-control study.


METHODS
Ninety-seven consecutive patients attending a glaucoma clinic. These included 38 patients with primary open-angle glaucoma (POAG), 19 with normal pressure glaucoma (NPG), 16 with pseudoexfoliation glaucoma (PXE), and 24 with ocular hypertension (OHT). Ninety-four age-matched participants without glaucoma served as a control population.


METHODS
Serum was analyzed for the presence of H. pylori-specific immunoglobulin G antibodies by enzyme-linked immunosorbent assay.


METHODS
Serologic analysis for H. pylori.


RESULTS
Seropositivity for H. pylori was higher in patients with glaucoma (26.0%) than in controls (20.2%), but this did not achieve statistical significance (P = 0.46). A total of 26.3% of POAG patients, 26.3% of NPG patients, 25.0% of PXE patients, and 25.0% of OHT patients were seropositive.


CONCLUSIONS
This study suggests that exposure to H. pylori infection is not associated with open-angle glaucoma.
Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada.
Peter H
PH
Galloway
Simon J
SJ
Warner
Muhammad G
MG
Morshed
Frederick S
FS
Mikelberg
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood; D001955:British Columbia / Q000453:epidemiology; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D017889:Exfoliation Syndrome / Q000382:microbiology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000382:microbiology*; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000382:microbiology; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G