Novel synthesis of 1-aroyl-3-aryl-4-substituted imidazole-2-thiones.
[reaction: see text] An efficient route to 1-aroyl-3-aryl-4-substituted imidazole-2-thiones (2, 4-6) has been developed. The methodology involves the cyclization of 1-aroyl-3-arylthioureas with a variety of carbonyl compounds bearing alpha-H in the presence of bromine and triethylamine.
Department of Chemistry, Suzhou University, Suzhou 215006, Jiangsu Province, China.
Run-Sheng
RS
Zeng
Jian-Ping
JP
Zou
San-Jun
SJ
Zhi
Jun
J
Chen
Qi
Q
Shen
D019380:Anti-HIV Agents / Q000138:chemical synthesis*; D003500:Cyclization; D007093:Imidazoles / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013871:Thiones / Q000138:chemical synthesis*
D019380:Anti-HIV Agents; D007093:Imidazoles; D007202:Indicators and Reagents; D013871:Thiones