Analgesic, antipyretic and anti-inflammatory effects of essential oil of Lippia multiflora.
The essential oil of Lippia multiflora Moldenke (Verbenaceae) produced by conventional hydrodistillation was analyzed and studied for its analgesic, antipyretic and anti-inflammatory activities in rats and mice. At the doses used (2, 4 and 8 ml/kg o.s.) the essential oil of L. multiflora showed significant and dose-dependent analgesic effect on acetic acid-induced writhing in mice. Only the dose of 8 ml/kg of essential oil, antagonized hyperexia induced by brewer's yeast. No effect on granuloma formation was observed.
Laboratoire de Biochimie et Pharmacologie, Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, B P 69, Congo. abena_cg@yahoo.com
A A
AA
Abena
M
M
Diatewa
G
G
Gakosso
M
M
Gbeassor
Th
T
Hondi-Assah
J M
JM
Ouamba
D019342:Acetic Acid; D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000517:prevention & control*; D015745:Granuloma, Foreign-Body / Q000517:prevention & control; D032411:Lippia; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects*; D008517:Phytotherapy; D018515:Plant Leaves; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012441:Saccharomyces cerevisiae
D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D010938:Plant Oils; D019342:Acetic Acid