Peripheral T cell lymphoma-associated hemophagocytic syndrome in a patient with human adjuvant disease.
Hemophagocytic syndrome (HPS) is a rare complication of lymphoma. We report a 70-year-old woman with human adjuvant disease who developed lymphoma-associated HPS (LAHPS) and elevated serum soluble interleukin (IL)-2 receptor. Despite intensive therapy, she died of pneumonia. Necropsy revealed a prominent spleen containing atypical T cells and many erythrophagocytizing histiocytes.
Negishi
Masao
M
Division of Rheumatology and Clinical Immunology, First Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan.
Kasama
Tsuyoshi
T
Hanaoka
Ryosuke
R
Ide
Hirotsugu
H
Inokuma
Shigeko
S
D000276:Adjuvants, Immunologic; D001169:Arthritis, Experimental / Q000150:complications / Q000473:pathology*; D001803:Blood Transfusion; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications / Q000473:pathology* / Q000628:therapy; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D013154:Spleen / Q000473:pathology
D000276:Adjuvants, Immunologic; D016179:Granulocyte Colony-Stimulating Factor; D016572:Cyclosporine; D008775:Methylprednisolone