Successful renal transplantation in a child with ANCA-associated microscopic polyangiitis.
Crescentic glomerulonephritis (CGN) is a clinicopathologic entity which is characterized by severe renal dysfunction of rapid onset with glomerular crescents. Type III CGN is associated with the absence of glomerular immune complex deposition (pauci-immune) and is associated with antineutrophil cytoplasmic antibody (ANCA). Microscopic polyangiitis and idiopathic pauci-immune necrotizing glomerulonephritis (NCGN) are strongly associated with ANCA directed against myeloperoxidase (anti-MPO). We describe here an unusual pediatric patient with MPO-ANCA-associated rapidly progressive glomerulonephritis (RPGN), emphasizing the management and outcome of the disease.
Department of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey. nbesbas@hacettepe.edu.tr
Nesrin
N
Besbas
Fatih
F
Ozaltin
Keriman
K
Tinaztepe
Safak
S
Güçer
Seza
S
Ozen
Mehmet
M
Bakkaloglu
Aysin
A
Bakkaloglu
D019867:Anti-Glomerular Basement Membrane Disease / Q000473:pathology / Q000601:surgery; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood / Q000276:immunology*; D001706:Biopsy; D002648:Child; D003404:Creatinine / Q000097:blood; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology / Q000473:pathology / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D016030:Kidney Transplantation; D009195:Peroxidase / Q000276:immunology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000209:etiology / Q000473:pathology / Q000601:surgery*
D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents; D003404:Creatinine; D009195:Peroxidase