[Association between non-steroid antiinflammatory drugs intake and decompensation of heart failure].
OBJECTIVE
Our purpose was to estimate the association between the intake of non-steriodal anti-inflammatory drugs (NSAIDs) and hospitalization due to heart failure (HF) and to assess the effect of selective COX-2 inhibitors.


METHODS
This was a case-control study, including 982 patients with HF, and 788 controls, with a history of HF who were hospitalized in 10 hospitals of the community of Madrid.


RESULTS
The use of NSAIDs (other than aspirine at low doses) was associated with an increase in the risk of hospitalization due to HF (OR crude = 1.59; 95% interval confidence, 1.20-2.09; OR adjusted, 1.40; 95% interval confidence, 1.03-1.90).


CONCLUSIONS
Intake of NSAIDs is associated with an increased risk of hospitalization due to HF, in susceptible patients.
Servicio de Farmacología Clínica. Hospital Clínico San Carlos. Madrid. España. leonor_laredo@hotmail.com
Leonor
L
Laredo
Angel
A
Rodríguez
Emilio
E
Vargas
Alfonso
A
Moreno
Alfonso
A
Cruz
Juan de Dios
Jde D
García
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D016022:Case-Control Studies; D016001:Confidence Intervals; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006333:Heart Failure / Q000139:chemically induced* / Q000188:drug therapy / Q000453:epidemiology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D016017:Odds Ratio
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors