Effect of lamotrigine on mood and cognition in patients receiving chronic exogenous corticosteroids.
Mood changes, cognitive deficits, and psychosis have been reported during corticosteroid therapy. However, minimal data are available on the treatment of these side effects. This pilot study examined the effect of 12 weeks of open-label lamotrigine treatment (dose: mean=340 mg/day, SD=65) on mood and cognition in five patients receiving prescription corticosteroids continuously for at least 6 months before study entry. The participants showed significant improvement in cognition with lamotrigine. Two subjects who met criteria for a current major depressive episode at baseline had baseline-to-exit reductions in scores on the Hamilton Depression Rating Scale of more than 20 points. These pilot data suggest that lamotrigine may be associated with improved mood and performance on cognitive tasks in steroid-treated patients. Larger controlled trials are needed to confirm these preliminary findings.
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390-8849, USA. Sherwood.Brown@UTSouthwestern.edu
E Sherwood
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Brown
Alan
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Frol
Leonardo
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Bobadilla
Vicki A
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Nejtek
Dana C
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Perantie
Harminder
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Dhillon
D000328:Adult; D000339:Affect / Q000187:drug effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001249:Asthma / Q000188:drug therapy; D003071:Cognition / Q000187:drug effects*; D003865:Major Depressive Disorder / Q000139:chemically induced / Q000188:drug therapy; D003882:Dermatomyositis / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010555:Personality Inventory; D010865:Pilot Projects; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects*; D014227:Triazines / Q000009:adverse effects / Q000627:therapeutic use*
D014227:Triazines; D000077213:Lamotrigine; D011241:Prednisone