Glyco-helix: parallel lactose-lactose interactions stabilize an alpha-helical structure of multi-glycosylated peptide.
Glyco-helix is designed as a novel model system to investigate cis carbohydrate-carbohydrate interactions. Adhesive Lac-Lac interactions stabilize alpha-helix of Lac-peptide in the presence of fluorinated alcohols, but no such an interaction was observed in GlcNAc-peptide.
Department of Chemistry, Graduate School of Engineering, Kyushu University, Hakozaki, 6-10-1, Fukuoka 812-8581, Japan.
Teruaki
T
Hasegawa
Tomikazu
T
Sasaki
D000117:Acetylglucosamine / Q000031:analogs & derivatives* / Q000737:chemistry; D000595:Amino Acid Sequence; D002122:Calcium Chloride / Q000737:chemistry; D002942:Circular Dichroism; D006020:Glycopeptides / Q000737:chemistry*; D006031:Glycosylation; D007785:Lactose / Q000737:chemistry*; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D012965:Sodium Chloride / Q000737:chemistry
D006020:Glycopeptides; D012965:Sodium Chloride; D007785:Lactose; D002122:Calcium Chloride; D000117:Acetylglucosamine