Great potentiality of neonatal facial motor neurons for neural plasticity as determined by functionally essential neuronal population.
The present study was undertaken to determine the neuronal population essential for normal and minimal facial function of young adult rats that had received various degrees of crush injuries to the facial nerve in the neonatal period. Using a neuronal tracer, it was found in young adult rats receiving neonatal injuries that the minimum number of tracer-labeled facial motor neurons necessary for normal facial function corresponded to 13-14% of the neurons (2540+/-64) of the age-matched control animals, whereas the minimum number of neurons necessary for minimal facial function corresponded to 5%. On the other hand, the minimum numbers of tracer-labeled facial motor neurons necessary for normal and minimal facial function of young adult rats that received various degrees of crush injuries corresponded to 61 and 27-30%, respectively, of the neurons (2540+/-64) of the uninjured control animals. These results indicate that the facial function of animals with nerves crushed at the neonatal stage can be adequately maintained by a very small population of neurons, implying a great potential of neonatal neurons for neural plasticity.
Koyama
J
J
Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.
Yokouchi
K
K
Fukushima
N
N
Kawagishi
K
K
Moriizumi
T
T
D000818:Animals; D000831:Animals, Newborn; D005145:Face / Q000294:innervation*; D020220:Facial Nerve Injuries / Q000503:physiopathology*; D005456:Fluorescent Dyes; D009046:Motor Neurons / Q000502:physiology*; D009409:Nerve Crush; D009473:Neuronal Plasticity / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013266:Stilbamidines
C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D005456:Fluorescent Dyes; D013266:Stilbamidines