[Assessment on acute toxicity of combined pesticides].
The acute oral toxicity (LD50) of two pesticides combined from 3 categories of insecticides, i.e. organophosphates(OPs), pyrethroids and carbamates, was evaluated by Harris method on equal toxicity doses. The OPs compounds studied included: methylparathion, omethoate, methamidophos, phoxim, dichlorvos, profenofos, isocarbophos and malathion; the pyrethroids: alpha-cypermethrin, deltamethrin, fenvalerate and fenpropathrin; the carbamates: methomyl, isoprocarb and metolcarb. The mixtures of two OPs on the combination of dichlorvos plus omethoate and methamidophos plus profenofos showed additive effects, but methylparathion plus phoxim showed antagonistic effect. Most of the combination of OPs with pyrethroids showed synergistic effects, such as the mixtures of phoxim plus deltamethrin, phoxim plus alpha-cypermethrin, methlyparathion plus alpha-cypermethrin and ioscoarbphos plus fenpropthrin, with the exception of two mixtures showed additive effects: phoxim plus fenvalerate resulting in 1.5 times higher toxicity than expected, while dichlorvos plus deltamethrin resulting in less toxicity than expected. The effects of the mixtures of OPs and carbamates: phoxim plus methomyl and methamidophos plus metolcarb, were all additive, but the mixtures of he methylparathion plus methomyl showed antagonistic effect and malathion plus isoprocarb were synergistic. The biochemical mechanisms of changed toxicity of pesticides mixtures were discussed based on their toxicokinetics and toxicodynamics. It was concluded that the combined effects of insecticide mixtures were additive for OPs plus OPs or plus carbamates in most cased, but synergistic for OPs plus pyrethroids.
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing 100050, China.
J
J
Sun
B
B
Chen
P
P
Yao
D000818:Animals; D004357:Drug Synergism; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D008724:Methomyl / Q000633:toxicity; D008743:Methyl Parathion / Q000633:toxicity; D011722:Pyrethrins / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
D007306:Insecticides; D011722:Pyrethrins; D008724:Methomyl; C017160:cypermethrin; D008743:Methyl Parathion