Typical and atypical antipsychotic medications differentially affect two nondeclarative memory tasks in schizophrenic patients: a double dissociation.
Nondeclarative memory (NDM) has subtypes associated with different brain regions; learning of a probabilistic classification task is impaired by striatal damage and learning of a gambling task is impaired by ventromedial prefrontocortical damage. Typical and atypical antipsychotic medications differentially affect immediate early gene expression in the striatum and frontal cortex in normal rats. This suggested the hypothesis that schizophrenic patients treated with typical antipsychotics will have impaired probabilistic classification learning (PCL) and that similar patients treated with atypical antipsychotics will have impaired learning of the gambling task. Groups of schizophrenia patients treated with typical or atypical antipsychotics did not differ from each other on the Brief Psychiatric Rating Scale (BPRS), Mini Mental State Exam (MMSE) or a number of indexes of the Wisconsin Card Sorting Task (WCST) but performed worse than normal controls on these instruments. In the first study, patients treated with typicals (n=20) but not atypicals (n=20) or normal controls (n=32) were impaired in probabilistic classification. In the second study, those treated with atypicals (n=18) but not typicals (n=18) or normal controls (n=18) were impaired in the gambling task. Results suggest that typical and atypical antipsychotics differentially affect nondeclarative memory mediated by different brain regions.
Beninger
Richard J
RJ
Department of Psychology, Queen's University, K7L 3N6, Kingston, ON, Canada. beninger@psyc.queensu.ca
Wasserman
James
J
Zanibbi
Katherine
K
Charbonneau
Danielle
D
Mangels
Jennifer
J
Beninger
Bruce V
BV
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D010054:Brief Psychiatric Rating Scale / Q000706:statistics & numerical data; D003342:Corpus Striatum / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000503:physiopathology; D005715:Gambling / Q000523:psychology*; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000187:drug effects* / Q000502:physiology; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000187:drug effects / Q000503:physiopathology; D011337:Probability Learning; D011340:Problem Solving / Q000187:drug effects / Q000502:physiology; D011594:Psychometrics; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents