Long-term administration of Polygonum multiflorum Thunb. reduces cerebral ischemia-induced infarct volume in gerbils.
Focal cerebral ischemia was produced by an occlusion of the middle cerebral artery for 1, 3 and 24 hours in gerbils. Infarct volumes were determined by 2,3,5-triphenyltetrazolium chloride (TTC) transcardiac perfusion 24 hours after cerebral ischemia. Significant and consistent infarct sizes were produced in gerbils subjected to 24-hour occlusion of the middle cerebral arterey when compared to the 1 and 3-hour occlusion group. Longterm pretreatment of the 50% ethanol extract of Polygonum multiflorum Thunb. for 2 weeks significantly reduced the infarct volume by 50% as compared to that of the 24-hour occlusion group. The results revealed that long term pretreatment of Polygonum multiflorum Thunb. may protect the brain against focal cerebral ischemia.
Chan
Yin-Ching
YC
Department of Nutrition, Providence University, Taichung, 433 Taiwan, ROC.
Wang
Ming-Fu
MF
Chen
Ya-Ching
YC
Yang
Dar-Yu
DY
Lee
Ming-Shih
MS
Cheng
Fu-Chou
FC
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005849:Gerbillinae; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology; D008297:Male; D009043:Motor Activity / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018517:Plant Roots; D028502:Polygonum; D011897:Random Allocation; D013997:Time Factors
D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents