Age-associated sex differences in response to food deprivation in two animal tests of anxiety.
The effects of mild food deprivation (7 days of food restricted to once daily feeding to maintain body weights at 85% of free-feeding weights) were examined in adult male and female and adolescent female rats tested in the elevated plus maze and social interaction tests of anxiety. In adult male rats, food deprivation appeared to have an anxiolytic effect in the plus-maze as it significantly increased the percentage of entries onto open arms and the percentage of time spent on the open arms, without changing the number of closed arm entries. There were no effects of food deprivation in adult females, although in adolescent females food deprivation significantly increased the percentage of open arm entries rats. Adolescent female rats have female brains, but do not have circulating gonadal hormones and thus these results suggest that circulating female gonadal hormones are able to suppress some of the effects of mild food deprivation in the plus-maze. In the social interaction test, there were no effects of food deprivation in any group on the time spent in social interaction. There were opposite effects on locomotor activity in the adult male and female rats, with deprivation increasing activity in males and decreasing it in females. There were no effects of food deprivation on locomotor activity in the adolescent females, suggesting that circulating gonadal hormones were responsible for the bidirectional effects in the adult rats. In both tests there were age-associated differences in the female rats, with the adolescent females being less anxious (higher percentage of open arm entries and increased social interaction) than the adults.
Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King's College London, Hodgkin Building, Guy's Campus, London SE1 1 UL, UK. rachel.f.genn@kcl.ac.uk
Rachel F
RF
Genn
Sonia A
SA
Tucci
Amy
A
Thomas
Jessica E
JE
Edwards
Sandra E
SE
File
D000375:Aging / Q000502:physiology*; D000818:Animals; D001007:Anxiety / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D005508:Food Deprivation / Q000502:physiology*; D007398:Interpersonal Relations; D008297:Male; D018782:Maze Learning / Q000502:physiology; D011897:Random Allocation; D051381:Rats; D012727:Sex Characteristics