Secoiridoid glucosides with free radical scavenging activity from the leaves of Syringa dilatata.
Activity-guided fractionation of the EtOAc and MeOH extract of the leaves of Syringa dilatata NAKAI furnished one free radical scavenger, the secoiridoid glucoside oleuropein together with ligstroside and an iridoid glucoside, syringopicroside. Oleuropein interacted with the stable free radical, 1,1-diphenyl-2-picrylhydrazyl (DPPH), and showed an IC(50) value of 40.4 microM. L-Ascorbic acid as a positive control showed an IC(50) value of 50.3 microM.
Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Korea.
Hyuncheol
H
Oh
Eun-Kyoung
EK
Ko
Do-Hoon
DH
Kim
Kyu-Kwan
KK
Jang
Sung-Eun
SE
Park
Ho-Sub
HS
Lee
Youn-Chul
YC
Kim
D001713:Biphenyl Compounds; D002851:Chromatography, High Pressure Liquid; D016166:Free Radical Scavengers / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D039823:Iridoids / Q000737:chemistry*; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves; D031662:Syringa
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D039823:Iridoids; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl