No genetic association between polymorphisms in the Fyn kinase gene and age of schizophrenic onset.
Since the mRNA level of Fyn, a neurodevelopmental molecule, expression had been reported to be increased in postmortem schizophrenic prefrontal cortex and showed a strong correlation with age of disease onset, we investigated whether the three polymorphisms of the Fyn gene on genomic DNA (-93A/G, IVS10+37T/C and Ex12+894T/G) also had an effect on clinical onset in 139 unrelated schizophrenics. A comparison of the age of onset among the groups classified by polymorphisms showed no significant difference. Moreover, all allelic combinations also failed to show significant differences in age of onset among the groups. The present study reports that there is no indication that the three polymorphisms in the Fyn gene are associated with the age of schizophrenic onset.
Ohnuma
Tohru
T
Department of Psychiatry, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 343-0032, Japan. tohru.oonuma@nifty.ne.jp
Shibata
Nobuto
N
Matsubara
Yoichiro
Y
Sato
Satoshi
S
Yamashina
Mitsuru
M
Arai
Heii
H
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D051076:Proto-Oncogene Proteins c-fyn; D012189:Retrospective Studies; D012559:Schizophrenia / Q000145:classification / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism
D011518:Proto-Oncogene Proteins; C494957:FYN protein, human; D051076:Proto-Oncogene Proteins c-fyn