No association of inducible nitric oxide synthase gene ( NOS2A) to multiple sclerosis.
Nitric oxide (NO) is a nonspecific inflammatory mediator that has been involved in the pathogenesis of multiple sclerosis (MS). The influence of the promoter polymorphism of inducible NO synthase gene ( NOS2A) on susceptibility and outcome was studied in 140 MS Spanish patients and 147 healthy controls matched for sex, age, and ethnicity. No association was found between MS susceptibility, course or outcome of the disease, and NOS2A polymorphisms.
Servei de Neurologia, Hospital Clínic, Villarroel 170, Barcelona 08036, Spain.
Yolanda
Y
Blanco
Jordi
J
Yagüe
Francesc
F
Graus
Albert
A
Saiz
D000328:Adult; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000201:enzymology / Q000235:genetics*; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052247:Nitric Oxide Synthase Type II; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics
C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II