Tumor-host interactions accompanying the growth of the G:5:113 fibrosarcoma in the mouse: possibilities for a new therapeutic approach?
The experiments were aimed at describing in detail some interactions between a solid tumor growing from subcutaneously transplanted G:5:113 fibrosarcoma cells in vivo and its mouse host. The tumor was found to elevate significantly the number of granulocytes in the peripheral blood of the host after having achieved the volume of about 1 cm3 (day 40 after transplantation). Blood plasma from fibrosarcoma-bearing mice stimulated proliferation of progenitor cells for granulocytes and macrophages (GM-CFC) in vitro and suppressed growth of G:5:113 cell population in culture. Interestingly, both effects were observable as early as week 1 when the tumor was still macroscopically invisible and unpalpable. Conditioned medium from cultures of G:5:113 fibrosarcoma cells stimulated proliferation of GM-CFC in vitro. These findings might represent a starting point for studies aimed at designing new therapeutic approaches for the treatment of fibrosarcoma.
Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 612 65 Brno, Czech Republic.
Zuzana
Z
Hoferová
Antonín
A
Vacek
Michal
M
Hofer
Nadezda O
NO
Macková
Karel
K
Soucek
Alena
A
Egyed
Peter
P
Fedorocko
D000818:Animals; D002452:Cell Count; D002453:Cell Cycle / Q000502:physiology*; D002455:Cell Division; D002470:Cell Survival / Q000502:physiology*; D017077:Culture Media, Conditioned; D005354:Fibrosarcoma / Q000097:blood / Q000473:pathology*; D006098:Granulocytes / Q000473:pathology; D007958:Leukocyte Count; D051379:Mice; D008809:Mice, Inbred C3H; D014407:Tumor Cells, Cultured
D017077:Culture Media, Conditioned