White matter injury in the premature infant: a comparison between serial cranial sonographic and MR findings at term.
OBJECTIVE
The accuracy of cranial sonography (US) in characterizing white matter (WM) injury in the premature infant is unclear. This study was aimed to assess the sensitivity and specificity of serial cranial US during the first 6 weeks of life in comparison to MR imaging at term (week of expected delivery) in characterizing the presence of WM injury in a cohort of 96 very low birth weight (VLBW) infants.


METHODS
A blinded investigator reviewed serial cranial sonograms for the presence of WM echolucency and echodensity, including its duration and extent. These abnormalities were compared with a second independent investigator's evaluation to determine the sensitivity and specificity of cranial WM abnormalities at US.


RESULTS
The presence of prolonged echodensity (>7 days) in the WM on neonatal cranial sonograms demonstrated low sensitivity (26%) and a low positive predictive value (36%) for the presence of noncystic WM injury, as detected on MR images at term. Extensive cystic lesions detected on MR images were all identified during earlier cranial US.


CONCLUSIONS
Neonatal cranial US of the VLBW infant demonstrates high reliability in the detection of cystic WM injury but has significant limitations in the demonstration of noncystic WM injury. This deficiency of neonatal cranial US is important, because noncystic WM injury is considerably more common than cystic WM injury.
Murdoch Children's Research Institute, Melbourne, Australia.
Terrie E
TE
Inder
Nigel J
NJ
Anderson
Carole
C
Spencer
Scott
S
Wells
Joseph J
JJ
Volpe
D001921:Brain / Q000473:pathology*; D015331:Cohort Studies; D004453:Echoencephalography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007969:Leukomalacia, Periventricular / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity