[Toxic effect of fluoride-arsenic on the reproduction and development of rats].
To determine the effects of the fluoride-arsenic exposure on the reproductive function and the development of offspring. Two generations-one nest reproduction was studied in Wistar rats to assess the changes of reproductive function and structure of ovary and development of their offspring after rats were exposed to different doses of fluoride(NaF)-arsenic(As2O3) orally. The rates of the pregnancy, normal parturition, survival and feeding survival in high dose group were lower than that in low dose groups and control. The rates of pregnancy were 73.08% and 61.54% in high dose groups, and 92.31% and 84.62% in the control. But the contents of fluoride and arsenic in rats' offspring were increased. The weights of rats' offspring in high dose group were lighter than that in control. The average weights were 38.45 g in high dose group and 60.84 g in control one month after birth. Pathological changes could be found in each stage of oocytes with transmission electron microscope(TEM). Conclusion Fluoride-arsenic exposure has adverse effects on the reproductive system and the development of rats' offspring.
College of Public Health, Xinjiang Medical University, Urumqi 830054, China.
C
C
Zhang
B
B
Ling
J
J
Liu
G
G
Wang
D000818:Animals; D000077237:Arsenic Trioxide; D001152:Arsenicals; D005260:Female; D008297:Male; D018811:Maternal Exposure; D009865:Oocytes / Q000187:drug effects*; D010087:Oxides / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012969:Sodium Fluoride / Q000633:toxicity*
D001152:Arsenicals; D010087:Oxides; D012969:Sodium Fluoride; D000077237:Arsenic Trioxide