Unprecedented palladium-catalyzed cross-coupling reaction of alpha-bromo sulfoxides with boronic acids.
[reaction: see text] A new Suzuki-type palladium-catalyzed reaction of boronic acids with alpha-bromo sulfoxides has been developed using a protocol similar to the well-documented reaction of boronic acids with aryl halides. Both cross-coupling and homocoupling processes were observed. The best yields in cross-coupling products were obtained when the presence of oxygen was carefully excluded using degassed solvents. The oxidative addition palladium complex intermediate could be isolated and characterized by X-ray single-crystal diffraction.
Departamento de Química Orgánica, Universidad de Valencia, Avda Vicent Andres Estelles s/n 46100 Burjassot-Spain.
Nuria
N
Rodríguez
Ana
A
Cuenca
Carmen
C
Ramírez de Arellano
Mercedes
M
Medio-Simón
Gregorio
G
Asensio