Two cases of cerebral aspergillosis successfully treated with voriconazole.
Described here are two cases of cerebral aspergillosis successfully treated with voriconazole after the failure of first-line treatment with amphotericin B deoxycholate. In both cases, clinical and radiological cure was achieved within 6 weeks. Voriconazole should be considered as first-line therapy for cerebral aspergillosis.
Service de Médecine Interne, Hópital Beaujon, 100 Boulevard du Général Leclerc, 92110, Clichy, France.
V
V
de Lastours
A
A
Lefort
M
M
Zappa
V
V
Dufour
N
N
Belmatoug
B
B
Fantin
D000284:Administration, Oral; D000935:Antifungal Agents / Q000008:administration & dosage*; D001927:Brain Diseases / Q000175:diagnosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020953:Neuroaspergillosis / Q000175:diagnosis / Q000188:drug therapy*; D011743:Pyrimidines / Q000008:administration & dosage*; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole