[Inflammatory mediator in patients with obstructive jaundice and its effect on renal function].
OBJECTIVE
To investigate the effect of inflammatory transmitter on renal function in obstructive jaundice.


METHODS
15 patients with obstructive jaundice (OJ) as the experimental group and 15 non-joundiced patients as the control group were involved in this study. The plasma ET, LPS, TNF-alpha, IL-6, IL-8 and urine REP, TFR, ALB were measured in 15 patients with OJ before and 1, 4, 7 days after surgery and in 15 patients without jaundice as controls.


RESULTS
The levels of plasma ET, LPS, TNF-alpha, IL-6, IL-8 and urine RBP, TFR, ALB increased significantly at multiple time points as compared with those in the non-OJ patients (P < 0.05), and the changes of plasma ET, LPS, TNF-alpha, IL-6, IL-8 are the same as those of urine RBP, TFR, ALB.


CONCLUSIONS
These data suggest that there is interaction between ET, LPS, TNF-alpha, IL-6, IL-8 and the damage to renal function with OJ after surgery.
Department of Surgery, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
B
B
Peng
Y
Y
Wu
X
X
Wang
O
O
Qiang
M
M
Huang
X
X
Li
X
X
Liu
D000328:Adult; D000368:Aged; D002779:Cholestasis / Q000097:blood* / Q000503:physiopathology; D016232:Endothelins / Q000097:blood; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D016232:Endothelins; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha