Efficacy of an inactivated canine coronavirus vaccine in pups.
The efficacy of an inactivated CCoV vaccine (Duramune PC) was evaluated in four pups. Two dogs were maintained non-vaccinated. Ten days after the booster shot all the pups were challenged with a field CCoV strain administered by oro-nasal route. The vaccinated pups did not display clinical signs and shed the challenge-virus for 11.25 days, evaluated by virus isolation, and 13.5 days, evaluated by PCR assay. The two non vaccinated pups displayed mild diarrhoea at day post-challenge 4 and shed the challenge-virus for 14 and 15 days respectively, by virus isolation, and for 22 and 24 days respectively, by PCR assay.
Department of Animal Health and Well-being, Faculty of Veterinary Medicine, Valenzano, Bari, Italy.
A
A
Pratelli
A
A
Tinelli
N
N
Decaro
F
F
Cirone
G
G
Elia
S
S
Roperto
M
M
Tempesta
C
C
Buonavoglia
D000818:Animals; D018352:Coronavirus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D017939:Coronavirus, Canine / Q000276:immunology* / Q000302:isolation & purification; D004283:Dog Diseases / Q000276:immunology / Q000517:prevention & control*; D004285:Dogs; D015164:Vaccines, Inactivated; D014765:Viral Vaccines
D015164:Vaccines, Inactivated; D014765:Viral Vaccines