The degree of depression in Hamilton rating scale is correlated with the density of presynaptic serotonin transporters in 23 patients with Wilson's disease.
OBJECTIVE
One of the most frequent psychiatric symptoms in patients with Wilson's disease (WD) is depression. It has been suggested that depression is associated with deficits in serotonergic neurotransmission, but, hitherto, no measurements have been performed in WD.


METHODS
We prospectively examined 23 adult patients (12 women, 11 men, mean age 40 years) with WD for symptoms of depression using the Hamilton rating scale for depression (HAMD). We correlated the data with the presynaptic serotonin transporter density (SERT density) in the thalamus-hypothalamus and the midbrain-pons regions measured with high resolution single-photon emission computed tomography (SPECT) 24 hours after the application of 180 MBq 2beta-carbomethoxy-3beta-(4 [(123)I]iodophenyl)tropane ( [(123)I]b-CIT). The regions of interest were determined by coregistration with a standard MRI dataset.


RESULTS
A significant negative correlation was found between HAMD and SERT density in the thalamus-hypothalamus region (r = -0.49, p = 0.02), but not in the midbrain-pons (r = -0.31, p = 0.15).


CONCLUSIONS
We conclude that depression in patients with Wilson's disease is correlated with alterations of serotonergic neurotransmission in the thalamus-hypothalamus region.
Department of Neurology, University of Leipzig, Liebigstr. 22a, 04103 Leipzig, Germany.
B
B
Eggers
W
W
Hermann
H
H
Barthel
O
O
Sabri
A
A
Wagner
S
S
Hesse
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D016001:Confidence Intervals; D003863:Depression / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000523:psychology*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000523:psychology*; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D010361:Patients / Q000706:statistics & numerical data; D017729:Presynaptic Terminals / Q000378:metabolism; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales / Q000592:standards* / Q000706:statistics & numerical data; D050486:Serotonin Plasma Membrane Transport Proteins; D018709:Statistics, Nonparametric; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins