In vitro antagonistic activity of monoterpenes and their mixtures against 'toe nail fungus' pathogens.
The antibiotic effect of the active ingredients in Meijer medicated chest rub (eucalyptus oil, camphor and menthol) as well as the inactive ingredients (thymol, oil of turpentine, oil of nutmeg and oil of cedar leaf) were studied in vitro using the fungal pathogens responsible for onychomycosis, such as the dermatophytes Tricophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, Epidermophyton fl occosum and Epidermophyton stockdale. The zones of inhibition data revealed that camphor (1). menthol (2). thymol (3). and oil of Eucalyptus citriodora were the most efficacious components against the test organisms. The MIC(100) for mixtures of these four components in various carrier solvents revealed that formulations consisting of 5 mg/mL concentrations of each have a potential to be efffective in controlling onychomycosis.
Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA.
Russel S
RS
Ramsewak
Muraleedharan G
MG
Nair
Manfred
M
Stommel
Louise
L
Selanders
D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003883:Arthrodermataceae / Q000187:drug effects*; D002164:Camphor; D004821:Epidermophyton / Q000187:drug effects; D005052:Eucalyptus; D006801:Humans; D007223:Infant; D008297:Male; D000432:Methanol; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D008875:Middle Aged; D014009:Onychomycosis / Q000188:drug therapy*; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D028321:Plant Preparations / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D010938:Plant Oils; D028321:Plant Preparations; D002164:Camphor; D000432:Methanol