Broad-spectrum radical cyclizations boosted by polarity matching. Carbonylative access to alpha-stannylmethylene lactams from azaenynes and CO.
Free-radical mediated stannylcarbonylation of azaenynes provides a general [n + 1]-type annulation approach leading to alpha-stannylmethylene lactams. The cyclization is unusual in its breadth, covering 4-exo, 5-exo, 6-exo, 7-exo, and 8-exo modes.
Department of Chemistry, Faculty of Arts and Sciences, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan. ryu@ms.cias.osakafu-u.ac.jp
Ilhyong
I
Ryu
Hironari
H
Miyazato
Hiroki
H
Kuriyama
Kazutoshi
K
Matsu
Mami
M
Tojino
Takahide
T
Fukuyama
Satoshi
S
Minakata
Mitsuo
M
Komatsu