In vivo NMR studies of neurodegenerative diseases in transgenic and rodent models.
In vivo magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) provide unique quality to attain neurochemical, physiological, anatomical, and functional information non-invasively. These techniques have been increasingly applied to biomedical research and clinical usage in diagnosis and prognosis of diseases. The ability of MRS to detect early yet subtle changes of neurochemicals in vivo permits the use of this technology for the study of cerebral metabolism in physiological and pathological conditions. Recent advances in MR technology have further extended its use to assess the etiology and progression of neurodegeneration. This review focuses on the current technical advances and the applications of MRS and MRI in the study of neurodegenerative disease animal models including amyotrophic lateral sclerosis, Alzheimer's, Huntington's, and Parkinson's diseases. Enhanced MR measurable neurochemical parameters in vivo are described in regard to their importance in neurodegenerative disorders and their investigation into the metabolic alterations accompanying the pathogenesis of neurodegeneration.
The Nathan S. Kline Institute, Center for Advanced Brain Imaging, Orangeburg, New York 10962, USA. iychoi@nki.rfmh.org
In-Young
IY
Choi
Sang-Pil
SP
Lee
David N
DN
Guilfoyle
Joseph A
JA
Helpern
D000818:Animals; D030801:Animals, Genetically Modified; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008822:Mice, Transgenic; D019636:Neurodegenerative Diseases / Q000175:diagnosis* / Q000378:metabolism; D051381:Rats