Long-term effects of childhood abuse on brain and neurobiology.
Early stress is associated with long-term alterations in brain circuits and systems that mediate the stress response. Early stressors have lasting effects on the HPA axis and norepinephrine systems. Other brain systems that are involved include benzodiazepine, opiate, dopaminergic, and various neuropeptide systems. These neurochemical systems modulate function in brain regions, including the hippocampus, amygdala, and prefrontal cortex. Long-term alterations in these brain regions are hypothesized to play a role in the maintenance of PTSD, depression, and other psychiatric symptoms after childhood abuse.
Bremner
J Douglas
JD
Departments of Psychiatry and Radiology, Emory University School of Medicine, 1256 Briarcliff Road, Atlanta, GA 30306, USA. jdbremn@emory.edu
D001921:Brain / Q000254:growth & development / Q000378:metabolism / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D002649:Child Abuse / Q000523:psychology*; D002650:Child Abuse, Sexual / Q000523:psychology*; D005260:Female; D006801:Humans; D009479:Neuropeptides / Q000378:metabolism / Q000502:physiology; D013315:Stress, Psychological / Q000209:etiology / Q000503:physiopathology* / Q000523:psychology
D009479:Neuropeptides