[Molecular fundamentals of wound healing in diabetic foot syndrome].
BACKGROUND
The diabetic foot syndrome represents a considerable problem of health care. Due to the systemic character of diabetes mellitus, disturbances on the molecular level of wound healing are assumed.


METHODS
Growth factors and proteases affect the process of normal wound healing, and changes of their activity are relevant to the pathogenesis of the chronic wound. First studies describe the transition of a diabetic foot lesion to a nonhealing chronic wound on the molecular and cellular level.
This review reports on the current status of research and new implications for the treatment of diabetic foot syndrome.
Lobmann
Ralf
R
Klinik für Endokrinologie und Stoffwechselkrankheiten, Universität Magdeburg. ralf.lobmann@medizin.uni-magdeburg.de
Schultz
Gregory
G
Lehnert
Hendrik
H
D002908:Chronic Disease; D017719:Diabetic Foot / Q000235:genetics* / Q000503:physiopathology; D010450:Endopeptidases / Q000235:genetics / Q000502:physiology; D015870:Gene Expression / Q000502:physiology; D006133:Growth Substances / Q000235:genetics / Q000502:physiology; D006801:Humans; D014945:Wound Healing / Q000235:genetics*
D006133:Growth Substances; D010450:Endopeptidases