Methanol ingestion: prevention of toxic sequelae after massive ingestion.
Methanol ingestion, a rare but potentially fatal poisoning, is often difficult to diagnose in the emergency department (ED) and historically has been difficult to treat. In this article, we report a methanol ingestion with a blood concentration of 692 mg/dL, which was treated with 4-methylpyrazole (Fomepizole) and dialysis, without sequelae. To our knowledge, such a massive ingestion has never been treated with this modality without development of long-term disability. Another unusual feature of this case is the significantly elevated serum osmolal gap at presentation without elevation in anion gap, demonstrating the effects of co-ingestion of ethanol. Additionally, there was a marked disparity between the patient's breath alcohol analyzer level and the blood ethanol concentration, illustrating the inability of the breath alcohol analyzer to differentiate between volatile alcohols. Treatment of the methanol-poisoned patient with Fomepizole is discussed.
Department of Emergency Medicine, Regions Hospital, St. Paul, Minnesota 55101, USA.
Karen A
KA
Lushine
Carson R
CR
Harris
Joel S
JS
Holger
D000328:Adult; D000435:Alcoholic Intoxication / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D000931:Antidotes / Q000627:therapeutic use; D001784:Blood Gas Analysis; D001944:Breath Tests; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D004638:Emergency Treatment / Q000379:methods*; D000431:Ethanol / Q000506:poisoning*; D000077604:Fomepizole; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D000432:Methanol / Q000032:analysis / Q000378:metabolism / Q000506:poisoning*; D011720:Pyrazoles / Q000627:therapeutic use; D020127:Recovery of Function; D006435:Renal Dialysis; D013997:Time Factors; D016896:Treatment Outcome
D000931:Antidotes; D011720:Pyrazoles; D000431:Ethanol; D000077604:Fomepizole; D000432:Methanol