Effects of adding some dietary fibers to a cystine diet on the activities of liver antioxidant enzymes and serum enzymes in rats.
This study investigates whether some dietary fibers can the toxicity due to cystine added to the diet. Wistar rats were investigated for the effects of adding pectin, sugar beet fiber or konjac mannan to a cystine diet on the growth rate and on the activities of liver antioxidant enzymes and serum enzymes. The addition of pectin, sugar beet fiber or konjac mannan to the cystine diet resulted in a significant increase in both the food intake and body weight gain. Feeding the cystine diet caused lower activities of total and Cu,Zn-superoxide dismutase, and of catalase in the liver. The addition of pectin to the cystine diet counteracted the activities of the total and Cu,Zn-superoxide dismutase, and of catalase in liver. Of the dietary fibers tested, konjac mannan prevented the elevation of the two enzyme activities in the serum induced by feeding the cystine diet, indicating that this fiber might have the ability to alleviate hepatic damage due to dietary cystine.
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Nishi-9, Kita-9, Kita-ku, Sapporo 060-8589, Japan.
Guochun
G
He
Yoritaka
Y
Aoyama
D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000187:drug effects / Q000378:metabolism; D002482:Cellulose / Q000494:pharmacology; D003300:Copper / Q000737:chemistry; D003553:Cystine / Q000008:administration & dosage*; D004032:Diet; D004043:Dietary Fiber / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D006937:Hypercholesterolemia / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008351:Mannans / Q000494:pharmacology; D009954:Ornithine Carbamoyltransferase / Q000097:blood*; D010368:Pectins / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D015032:Zinc / Q000737:chemistry
D004043:Dietary Fiber; D008351:Mannans; D003553:Cystine; D003300:Copper; D010368:Pectins; D002482:Cellulose; D002374:Catalase; D013482:Superoxide Dismutase; D009954:Ornithine Carbamoyltransferase; D000410:Alanine Transaminase; D015032:Zinc