The efficacy of minocycline microspheres in the treatment of chronic periodontitis: statistical vs clinical significance.
This article addresses the benefits of using minocycline microspheres as an adjunct to conventional periodontal therapy. The author reviewed data from a large controlled clinical trial. The investigation indicated that scaling and root planing, plus minocycline microspheres, attained statistically significant improvements, with regard to several clinical parameters, when compared with scaling and root planing alone. Because it is the clinical meaningfulness of data that determines whether a therapy should be implemented, these data are interpreted with respect to their clinical relevance.
Greenstein
Gary
G
Department of Periodontology, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA.
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D003627:Data Interpretation, Statistical; D012534:Dental Scaling; D005884:Gingival Hemorrhage / Q000628:therapy; D006801:Humans; D008863:Microspheres; D008911:Minocycline / Q000008:administration & dosage / Q000627:therapeutic use*; D016017:Odds Ratio; D010514:Periodontal Pocket / Q000628:therapy; D010518:Periodontitis / Q000628:therapy*; D016745:Root Planing; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D008911:Minocycline