"Inactive" excipients such as Cremophor can affect in vivo drug disposition.
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-6602, USA.
Cristoph
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Wandel
Richard B
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Kim
C Michael
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Stein
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D002316:Cardiotonic Agents / Q000493:pharmacokinetics; D004077:Digoxin / Q000493:pharmacokinetics; D005079:Excipients; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D011092:Polyethylene Glycols
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002316:Cardiotonic Agents; D005079:Excipients; D004364:Pharmaceutical Preparations; C022131:cremophor; D011092:Polyethylene Glycols; D004077:Digoxin