Immune restoration disorders following HAART.
Highly active antiretroviral therapy (HAART) leads to a profound and sustained suppression of viral replication, along with a rise in CD4+ cells in most HIV-infected patients. However, reports are accumulating of growing numbers of patients suffering from opportunistic infections despite recovery of CD4+ cells and plummeting viral loads as part of a new syndrome called immune restoration disease. We describe this syndrome in two patients and review the current literature.
Davaro
R E
RE
University of Massachusetts Memorial Health Care, Memorial Campus, USA.
Himlan
P H
PH
D017088:AIDS-Related Opportunistic Infections / Q000209:etiology*; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D018791:CD4 Lymphocyte Count; D005260:Female; D006801:Humans; D008297:Male; D019562:Viral Load