Bioavailability of a pediatric amlodipine suspension.
Currently, a suspension of crushed tablets of amlodidpine is widely used in children with hypertension without knowledge of its bioavailability. A comparative bioavailability study of a tablet and suspension formulation of amlodipine was completed in 20 healthy adult volunteers. Bioequivalence of the suspension was not different from the tablets. These results support the use of the suspension in children who cannot take the tablet.
Lyszkiewicz
Dorothy A
DA
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada.
Levichek
Zina
Z
Kozer
Eran
E
Yagev
Yaron
Y
Moretti
Myla
M
Hard
Marjie
M
Koren
Gideon
G
D000328:Adult; D017311:Amlodipine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013535:Suspensions; D013607:Tablets
D002121:Calcium Channel Blockers; D013535:Suspensions; D013607:Tablets; D017311:Amlodipine