[A biomechanical model for simulating the deformation of a leukocyte adhered to the surface of a blood vessel under steady shear flow].
The adhesion of leukocytes to substrate is an important biomedical engineering problem and has drawn extensive research. In this study, we have proposed a compound drop model to simulate a leukocyte with a nucleus adhered to the surface of a blood vessel under steady shear flow. A two-dimensional computational fluid dynamics (CFD) is conducted to determine the local distribution of pressure on the surface of the adherent model cell. By introducing the parameter of deformation index (DI), we have investigated the deformation of the model cell and it's nucleus under controlled conditions. Our numerical results show that: (1) the model cell is capable of deformation with the increase of initial contact angle, capillary number, and Reynolds number, and that the cytoplasm is more deformable while the nucleus is more capable of resisting external imposed shear flow; (2) the model cell is not able to deform infinitely with the increase of external shear flow because the deformation index reaches a maximum; (3) pressure distribution confirms that there exists a region downstream of the cell, which produces high pressure to retard continuous deformation and provide a positive lift force on the cell. Our results of nucleus deformation may help to develop a better understanding of how leukocytes transduce external mechanical signal like shear stress into nucleus.
Liu
Xiaoheng
X
Institute of Biomedical Engineering, West China Medical Center of Sichuan University, Chengdu 610041. liuxiaohg@yahoo.com
Wang
Xiong
X
Huang
Hua
H
Chen
Huaiqing
H
D001696:Biomechanical Phenomena; D001808:Blood Vessels / Q000166:cytology* / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D002467:Cell Nucleus / Q000502:physiology; D007962:Leukocytes / Q000502:physiology*; D008955:Models, Cardiovascular; D009716:Numerical Analysis, Computer-Assisted