[Allergy investigations after two cases of adverse reactions to a neuromuscular blocking agent and management for subsequent general anaesthesia].
We report two cases of severe anaphylactic reactions to rocuronium. Diagnosis was confirmed by skin tests and specific IgE assay. Cross-reactivity to all neuromuscular blocking agents was investigated by intradermal tests and leucocyte histamine release test. Intradermal tests and leukocyte histamine release were negative for cisatracurium. The two patients had undergone a subsequent general anaesthesia using cisatracurium and did not present any adverse reaction.
Département d'anesthésie-réanimation, CHU Dijon, hôpital général, 21000 Dijon, France. NLouvier@dijon.fnclcc.fr
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Louvier
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Chomel
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Collet
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Juniot
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Pillet
D000368:Aged; D000707:Anaphylaxis / Q000503:physiopathology; D000732:Androstanols / Q000009:adverse effects* / Q000276:immunology; D000768:Anesthesia, General; D001279:Atracurium / Q000276:immunology; D003429:Cross Reactions; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000628:therapy*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects* / Q000276:immunology; D000077123:Rocuronium; D012882:Skin Tests
D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium; D007073:Immunoglobulin E; D000077123:Rocuronium