Changing patterns of buccal manifestations in AIDS.
BACKGROUND
Since the new antiviral drugs, e.g. protease inhibitors, arrived for the treatment of HIV-infected patients, the main oral infections associated with HIV disease have been brought under wider control.


METHODS
We examined 214 HIV-1 infected patients, that were in-patients or presented for consultation at the ENT department of the Hospital das Clinicas (São Paulo, University Medical School), between January 1996 and November 1998. We review the different disorders which may affect the buccal cavity of HIV patients, 57 patients (26.6%). We divided the patients into two groups to compare the differences in appearance of oral lesions in those ones receiving two or three antiviral drugs. We had 53 patients presenting with oral lesions, the majority of them from the group receiving two drugs.


RESULTS
The "P" value test was used and we concluded that there was a significant correlation between the use of triple antiviral therapy and a decrease of buccal lesions in HIV-infected patients.
Miziara
I D
ID
HIV Support Group Division of Clinical Otolaryngology, Hospital das Clinicas, Faculty of Medicine, University of Sao Paulo, Brazil.
Valentini
M júnior
Mj
Romano
F R
FR
Miniti
A
A
D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000188:drug therapy / Q000209:etiology*; D011480:Protease Inhibitors / Q000627:therapeutic use*; D012189:Retrospective Studies
D000998:Antiviral Agents; D011480:Protease Inhibitors