Keratitis caused by Scedosporium apiospermum successfully treated with a cornea transplant and voriconazole.
A case of Scedosporium apiospermum keratitis was successfully treated with oral voriconazole and penetrating keratoplasty. Voriconazole levels in the aqueous humor were 53% of the levels in plasma and exceeded the MIC for the isolate by sevenfold.
Department of Medical Microbiology, University Medical Center Nijmegen and Nijmegen University Center for Infectious Diseases, The Netherlands. e.nulens@mmb.umcn.nl
Eric
E
Nulens
Cathrien
C
Eggink
Antonius J M M
AJ
Rijs
Pieter
P
Wesseling
Paul E
PE
Verweij
D000935:Antifungal Agents / Q000627:therapeutic use*; D001203:Ascomycota / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D016039:Corneal Transplantation; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000382:microbiology* / Q000601:surgery; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole