Microbial transformation of dehydroepiandrosterone.
Transformation of dehydroepiandrosterone (DHEA) (1) was carried out by a plant pathogen Rhizopus stolonifer, which resulted in the production of seven metabolites. These metabolites were identified as 3beta,17beta-dihydroxyanandrost-5-ene (2), 3beta,17beta-dihydroxyandrost-4ene (3), 17beta-hydroxyandrost-4-ene-3-one (4), 3beta,11-dihydroxyandrost-4-ene-17-one (5), 3beta,7alpha-dihydroandrost-5-ene-17-one (6), 3A,7alpha,17beta-trihydroxyandrost-5-ene (7) and 11beta-hydroxyandrost-4,6-diene-3,17-dione (8). The structures of the transformed products were determined by the spectroscopic techniques.
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
M Iqbal
MI
Choudhary
S Adnan Ali
SA
Shah
S Ghulam
SG
Musharraf
Farzana
F
Shaheen
Atta-Ur-Rahman
D001711:Biotransformation; D003687:Dehydroepiandrosterone / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D012233:Rhizopus / Q000502:physiology*; D013055:Spectrophotometry, Infrared
D003687:Dehydroepiandrosterone