Peptides that regulate food intake: norepinephrine is not required for reduction of feeding induced by cholecystokinin.
CCK octapeptide (CCK-8) is released by the gut in response to a meal and acts via CCK(A) receptors on vagal afferents to induce satiety. However, the central neural pathways by which peripheral CCK-8 affects feeding are poorly understood. In the present study, we tested the hypothesis that norepinephrine (NE) is necessary for satiety induced by peripheral CCK-8 by using mice lacking dopamine beta-hydroxylase (Dbh(-/-)), the enzyme responsible for synthesizing NE and epinephrine from dopamine. We found that Dbh(-/-) mice are as responsive to the satiating effects of CCK-8 as their normal littermates.
Department of Biochemistry, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195-7370, USA. caesia@u.washington.edu
C Matson
CM
Cannon
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Palmiter
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D004299:Dopamine beta-Hydroxylase / Q000235:genetics / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005508:Food Deprivation; D017353:Gene Deletion; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009638:Norepinephrine / Q000096:biosynthesis / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology*; D012528:Satiety Response / Q000187:drug effects* / Q000502:physiology*; D015430:Weight Gain / Q000187:drug effects / Q000502:physiology; D015431:Weight Loss / Q000187:drug effects / Q000502:physiology
D010446:Peptide Fragments; C410885:cholecystokinin 8; D002766:Cholecystokinin; D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine