[Acute toxicity and bioavailability of nano red elemental selenium].
The reaction ratio of nano red elemental selenium (nanose) with GSH in vitro was one-tenth of that of sodium selenite. Mice were fed with nanose and sodium selenite separately at 50 micrograms/kg BW for 30 days. Both selenium forms could significantly increased Se concentration of blood, liver and activity of blood GSH-Px. Acute toxicity experiment of mice implied that the acute toxicity of nanose was nearly one-seventh of that of sodium selenite. The LD50 for nanose se was 112.98 mg kg BW, and the LD50 for sodium selenite was Se 15.72 mg/kg BW. The acute toxicity of nanose was low for mice.
Institute of Economics and Technology, University of Science and Technology, Hefei 230052, China.
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Gao
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Zhang
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Zhang
D000818:Animals; D001682:Biological Availability; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D008297:Male; D051379:Mice; D036103:Nanotechnology; D012643:Selenium / Q000493:pharmacokinetics* / Q000633:toxicity*; D018038:Sodium Selenite / Q000493:pharmacokinetics / Q000633:toxicity
D005979:Glutathione Peroxidase; D012643:Selenium; D018038:Sodium Selenite