Effect of Rhus coriaria L. (Anacardiaceae) on superoxide radical scavenging and xanthine oxidase activity.
Rhus coriaria L. (Anacardiaceae) is a well-known spice in the Middle-East and grown in the Central and East Anatolia region of Turkey. A methanolic extract (water-soluble part constituents) of R. coriaria, was found to be an uncompetitive inhibitor of xanthine oxidase and scavenger of superoxide radical in vitro with IC50 values of 172.5 microg/mL and 232 microg/mL respectively. Superoxide radicals were generated either by an enzymatic or a non-enzymatic system, and scavenging ability was evaluated by the inhibition of nitroblue tetrazolium reduction. This study provides evidence that a crude extract of R. coriaria exhibits interesting antioxidant properties, expressed either by the capacity to scavenge superoxide radical or to uncompetitively inhibit xanthine oxidase.
Candan
Ferda
F
Faculty of Science and Art, Department of Chemistry, University of Cumhuriyet, 58140 Sivas, Turkey. candan@cumhuriyet.edu.tr
D016166:Free Radical Scavengers / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D029045:Rhus / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000494:pharmacology*
D016166:Free Radical Scavengers; D010936:Plant Extracts; D013481:Superoxides; D014969:Xanthine Oxidase