Epidermal basement membrane zone components: ultrastructural distribution and molecular interactions.
The epidermal basement membrane zone (BMZ) comprises a multiprotein complex that aids the attachment of epidermal keratinocytes to the underlying dermis. In the last 5 years, our understanding of epidermal BMZ morphology, structure and function has dramatically improved. A complex network of molecular interactions has recently been identified that strengthen dermal-epidermal adhesion. Special attention will be paid to the recently identified network of interactions between BMZ components, including alpha6beta4 integrin interactions, the extracellular hook domain of collagen XVII and the looping structure of collagen VII molecules. We summarize some of the recent advances in the understanding of the biology and interactions of BMZ components from an ultrastructural and molecular perspective.
Department of Dermatology, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo 060-8638, Japan. jrm57@med.hokudai.ac.jp
James R
JR
McMillan
Masashi
M
Akiyama
Hiroshi
H
Shimizu
D001324:Autoantigens / Q000032:analysis; D001485:Basement Membrane / Q000648:ultrastructure*; D003094:Collagen / Q000032:analysis; D004817:Epidermis / Q000648:ultrastructure*; D006801:Humans; D016023:Integrins / Q000032:analysis; D007381:Intermediate Filament Proteins / Q000032:analysis; D007633:Keratins / Q000032:analysis; D007797:Laminin / Q000032:analysis; D024041:Non-Fibrillar Collagens; D051190:Plectin; D000097805:Collagen Type XVII
D001324:Autoantigens; D003094:Collagen; D016023:Integrins; D007381:Intermediate Filament Proteins; D007633:Keratins; D007797:Laminin; D024041:Non-Fibrillar Collagens; D051190:Plectin; D000097805:Collagen Type XVII; C495332:PLEC protein, human