Six patterns of drug-drug interactions.
The literature on pharmacokinetic drug-drug interactions usually focuses on various interactions relating to the cytochrome p450 system, phase II glucuronidation, and P-glycoprotein function. However, there has been relatively little examination of how the modes or patterns that govern these interactions can be systematically characterized to better anticipate drug-drug interactions in clinical practice. This article details a schema of six core patterns of pharmacokinetic drug-drug interaction relating to processes of induction and inhibition and the action of substrates. Case examples illustrating each pattern are provided.
Armstrong
Scott C
SC
Center for Geriatric Psychiatry, Tuality Forest Grove Hospital, Forest Grove, Oregon 97116, USA. scott.armstrong@tuality.org
Cozza
Kelly L
KL
Sandson
Neil B
NB
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000502:physiology*; D001711:Biotransformation; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004790:Enzyme Induction / Q000187:drug effects; D006801:Humans; D011619:Psychotropic Drugs / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D013379:Substrate Specificity
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D065607:Cytochrome P-450 Enzyme Inhibitors; D011619:Psychotropic Drugs; D003577:Cytochrome P-450 Enzyme System