Prolonged perilesional edema after treatment of parenchymal neurocysticercosis: methotrexate as a corticosteroid-sparing agent.
Treatment of neurocysticercosis with larvicidal agents is commonly complicated by seizures and transient neurologic deficits as a result of the host immune response to dying cysts. We report a case in which treatment with high-dose praziquantel resulted in prolonged perilesional edema requiring use of corticosteroids and corticosteroid-sparing agents for >1 year, suggesting a role for methotrexate in the management of this condition.
Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Paul B
PB
Keiser
Theodore E
TE
Nash
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D015766:Albendazole / Q000627:therapeutic use; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy; D006801:Humans; D008297:Male; D008727:Methotrexate; D008875:Middle Aged; D020019:Neurocysticercosis / Q000188:drug therapy* / Q000276:immunology; D011223:Praziquantel / Q000627:therapeutic use*; D041201:Taenia solium / Q000187:drug effects / Q000276:immunology*
D000305:Adrenal Cortex Hormones; D000871:Anthelmintics; D011223:Praziquantel; D015766:Albendazole; D008727:Methotrexate