[Dynamic cerebral blood flow autoregulation during sevoflurane anesthesia and TIVA].
BACKGROUND
Dynamic cerebral blood flow autoregulation during sevoflurane anesthesia and total intravenous anesthesia (TIVA) is unclear. We examined the cerebral circulation autoregulation during anesthesia by sevoflurane or TIVA.


METHODS
We measured mean blood pressure (MBP) and blood flow velocity of the middle cerebral artery by a transcranial Doppler ultrasonography before and during anesthesia using sevoflurane (volatile induction and maintenance of anesthesia (VIMA) group) and using propofol and fentanyl (TIVA group), and the relationship between changes in MBP and cerebral blood flow velocity was evaluated using the method of transfer function analysis. We calculated transfer gain and coherence by cross-spectrum from autospectra of MBP and cerebral blood flow velocity.


RESULTS
Transfer gain during anesthesia by TIVA in the low frequency range and high frequency range was near 1 cm.sec-1.mmHg-1. It was about equal to the value of transfer gain before anesthesia. But transfer gain during anesthesia by VIMA was above 2 cm.sec-1.mmHg-1.


CONCLUSIONS
These results suggest that TIVA by propofol and fentanyl maintains the dynamic autoregulation of cerebral blood flow, but sevoflurane impairs the autoregulation.
Department of Anesthesiology and Department of Hygiene and Space Medicine, Nihon University, Tokyo 173-8610.
Hisashi
H
Ishikawa
Kenichi
K
Iwasaki
Tomoki
T
Shiozawa
Kazuyoshi
K
Yajima
Naoto
N
Kubota
Setsuro
S
Ogawa
D000328:Adult; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects*; D008875:Middle Aged; D015742:Propofol / Q000494:pharmacology*; D000077149:Sevoflurane
D008738:Methyl Ethers; D000077149:Sevoflurane; D005283:Fentanyl; D015742:Propofol