Combinatorial chemistry as a new approach in antiparasitic drug discovery.
Key challenges in antiparasitic drug discovery are target selection and identification of appropriate small molecules as potential ligands for these targets. Novel tools and techniques continue to be developed to address both of these problems. This report focuses on the application of a suite of technologies summarized as combinatorial chemistry. Recent success using these technologies is explored, reasons for frequent failure are given and discussed.
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Andreas
A
Philipps-Universität Marburg, Marbacher Weg 6, 35037 Marburg, Germany. link@mailer.uni-marburgde
D000818:Animals; D000977:Antiparasitic Agents / Q000138:chemical synthesis* / Q000191:economics; D002626:Chemistry, Pharmaceutical; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D010271:Parasites / Q000187:drug effects / Q000201:enzymology; D013329:Structure-Activity Relationship
D000977:Antiparasitic Agents