New silyl ether reagents for the absolute stereochemical determination of secondary alcohols.
[reaction: see text] Herein we report a new set of silyl ether reagents for determining the enantiomeric purity and absolute stereochemistry of secondary alcohols. These derivatives are easily synthesized, provide straightforward spectroscopic results, and allow for facile recovery of the original chiral alcohol.
Williamson
R Thomas
RT
Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA. williar@wyeth.com
Barrios Sosa
Ana C
AC
Mitra
Abhijit
A
Seaton
Pamela J
PJ
Weibel
Douglas B
DB
Schroeder
Frank C
FC
Meinwald
Jerrold
J
Koehn
Frank E
FE
D000438:Alcohols / Q000737:chemistry*; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D004987:Ethers; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism
D000438:Alcohols; D004987:Ethers; D007202:Indicators and Reagents