Embolization with autologous fibroblast-attached platinum coils in canine carotid artery aneurysms: histopathological differences from plain coil embolization.
OBJECTIVE
This study was designed to evaluate the effect of autologous fibroblast-attached platinum coils on the promotion of intra-aneurysmal thrombus organization.


METHODS
Sidewall aneurysms were surgically created at common carotid arteries bilaterally in 5 dogs. Fibroblasts were obtained from the skins of the dogs and cultured and attached to unmodified platinum coils in a 5-day coculture. In each animal, one aneurysm was embolized with fibroblast-attached platinum coils (study group) and the other with plain platinum coils of the same size (control group).


RESULTS
All aneurysms were partially occluded; the mean occlusion rate was 67%. The histologic analyses performed 2 weeks after the embolization showed more advanced organization of intra-aneurysmal thrombus in the study group than in the control group (80% versus 53%, P = 0.02). Overgrowth of the organizing tissue and parent artery stenosis did not occur.


CONCLUSIONS
Our results suggest that autologous fibroblasts delivered with platinum coils could promote the organization of intra-aneurysmal thrombus. Although further research is needed, especially on the potential complications, endovascular treatment using autologous fibroblasts may be applied to aneurysm treatment.
Department of Neurosurgery, College of Medicine, Seoul National University, Seoul, Korea.
O-Ki
OK
Kwon
Moon Hee
MH
Han
Chang Wan
CW
Oh
In Ae
IA
Park
Gheeyoung
G
Choe
Kyoung Ho
KH
Lee
Kee-Hyun
KH
Chang
DaeHee
D
Han
D000783:Aneurysm / Q000628:therapy*; D000818:Animals; D002340:Carotid Artery Diseases / Q000628:therapy*; D002478:Cells, Cultured; D004285:Dogs; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D005347:Fibroblasts; D010984:Platinum; D018709:Statistics, Nonparametric
D010984:Platinum