Oxidative stress and heart disease: cardiac dysfunction, nutrition, and gene therapy.
Oxidative stress is defined as the imbalance between the generation of reactive oxygen species and antioxidant defense mechanisms. The cardiovascular system is a major target for reactive oxygen species. Cardiomyocytes and the vasculature of the heart can be severely damaged as a result of oxidative stress. In this paper, we discuss recent findings with respect to the role of oxidative stress in heart disease. The efficacies of treatments with vitamins and wine-derived compounds, as well as innovative gene therapeutic experiments that may potentially alleviate oxidative stress-induced disease, are also discussed.
Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, 351 Tache Avenue, Winnipeg, Manitoba R2H 2A6, Canada.
Elliott J F
EJ
Cantor
Enrico V
EV
Mancini
Rishi
R
Seth
Xing-Hai
XH
Yao
Thomas
T
Netticadan
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D015316:Genetic Therapy; D005822:Genetic Vectors; D006331:Heart Diseases / Q000517:prevention & control*; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012190:Retroviridae / Q000235:genetics; D014920:Wine
D017382:Reactive Oxygen Species