Extensive cortical damage in a case of Creutzfeldt-Jacob disease: clinicoradiological correlations.
MRI demonstrated extensive cortical involvement in a patient with pathologically proven Creutzfeldt-Jacob disease. The whole brain was atrophic; some of the supratentorial cortex, putamen and caudate nucleus gave high signal on T2-weighted images; the changes were more extensive on diffusion-weighted images (DWI). Comparison of the history, and the sites of atrophy and signal change suggested that the latter predominates in regions with long-lasting damage and prevalent gliosis, while high signal on DWI indicate current neuronal loss. This case widens the range of MRI findings in patients with Creutzfeldt-Jacob disease, and suggests that some information about the progression of the disease can be extracted from single MRI study.
Bergui
M
M
Neuroradiology, Ospedale S. G. Battista, University of Torino, Via Cherasco 15, 10126 Torino, Italy.
Bradac
G B
GB
Rossi
G
G
Orsi
L
L
D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged