Trypsin inhibitory effect of wedelolactone and demethylwedelolactone.
Wedelolactone (WL) and demethylwedelolactone (DWL) isolated from Eclipta alba were tested in the trypsin inhibition bioassay (in vitro). Both compounds showed potent activity. IC(50) values of WL and DWL were found to be 2.9 and 3.0 microg/mL respectively.
Syed
Samiulla D
SD
Bioassay Unit, R&D Centre, Natural Remedies Pvt Ltd, 5B, Veerasandra Indl Area, Hosur Road, Bangalore 561 229, India.
Deepak
Mundkinajeddu
M
Yogisha
Shivanna
S
Chandrashekar
Arun P
AP
Muddarachappa
Keerthi A
KA
D'Souza
Prashanth
P
Agarwal
Amit
A
Venkataraman
B V
BV
D000818:Animals; D002645:Chickens; D003374:Coumarins / Q000494:pharmacology*; D036601:Eclipta; D006801:Humans; D020128:Inhibitory Concentration 50; D010063:Ovum / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology*; D014357:Trypsin / Q000187:drug effects*
D003374:Coumarins; D010936:Plant Extracts; D011480:Protease Inhibitors; C051122:wedelolactone; C051123:demethylwedelolactone; D014357:Trypsin