Anti-GM1b IgG antibody is associated with acute motor axonal neuropathy and Campylobacter jejuni infection.
Anti-GM1 and anti-GM1b antibodies are frequently present in patients with Guillain-Barré syndrome (GBS) and accordingly, the two antibodies often coexist in the same patient. In order to study clinical and laboratory features of anti-GM1b-positive GBS, we analyzed the data of patients with anti-GM1b IgG antibody but no anti-GM1 IgG antibody. Of 86 consecutive patients, 10 had anti-GM1b antibody alone and frequently had acute motor axonal neuropathy (AMAN, 80%) and Campylobacter jejuni infection (60%). Of 10 patients with anti-GM1 antibody alone, four had AMAN, and two had C. jejuni infection. These results showed that GM1b could be a target molecule of autoantibody in the AMAN form of GBS subsequent to C. jejuni infection.
Ogawara
Kazue
K
Department of Neurology, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. ogawarak@green.ocn.ne.jp
Kuwabara
Satoshi
S
Koga
Michiaki
M
Mori
Masahiro
M
Yuki
Nobuhiro
N
Hattori
Takamichi
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000378:metabolism; D002169:Campylobacter Infections / Q000276:immunology*; D016123:Campylobacter jejuni; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005677:G(M1) Ganglioside / Q000031:analogs & derivatives* / Q000276:immunology* / Q000378:metabolism; D016537:Gangliosidosis, GM1 / Q000276:immunology / Q000378:metabolism; D020275:Guillain-Barre Syndrome / Q000145:classification / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000906:Antibodies; D007074:Immunoglobulin G; D005677:G(M1) Ganglioside; C029624:ganglioside M1b