Changes in blood viscosity with synthetic protease inhibitors.
We examined the effects on whole blood viscosity and coagulation time of various dosages of the synthetic low-molecular protease inhibitors gabexate mesilate and nafamostat mesilate with an oscillation-type viscometer. When either agent was added, blood viscosity decreased dose-dependently along a sigmoid-like curve. Furthermore, coagulation time was shorter with gabexate mesilate than with nafamostat mesilate owing to the differences of half-life in human blood. Thrombin generation, which results from the activation of coagulation factors, is inhibited by synthetic protease inhibitors and subsequently decreases blood viscosity dose-dependently.
Hitosugi
Masahito
M
Department of Legal Medicine, Dokkyo University School of Medicine, Tochigi 321-0293, Japan. hitosugi@dokkyomed.ac.jp
Niwa
Munehiro
M
Takahashi
Tomoyoshi
T
Kurosu
Akira
A
Nihei
Hirohisa
H
Nagai
Toshiaki
T
Tokudome
Shogo
S
D000328:Adult; D001550:Benzamidines; D001809:Blood Viscosity / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D016670:Gabexate / Q000494:pharmacology; D006146:Guanidines / Q000494:pharmacology; D006801:Humans; D008297:Male; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*
D001550:Benzamidines; D006146:Guanidines; D011480:Protease Inhibitors; D016670:Gabexate; C032855:nafamostat