Klebsiella-induced purpura fulminans in a Nigerian child: case report and a review of literature.
Purpura fulminans (PPF) is a very severe but rare acute thrombohaemorrhagic illness of infants and young children. It occurs mainly, in patients with either congenital or acquired deficiencies of proteins C and S and antithrombin III. Features of PPF include disseminated intravascular coagulopathy, symmetrical necrotic purpura and/or ecchymoses and symmetrical peripheral gangrene; digital and/ or limb(s) amputations and end-organ failure(s) may also occur. The case of a 3.5 year-old Nigerian girl, who developed PPF following Klebsiella-rhinoscleromatis septicaemia is reported to illustrate the seriousness of the disease and the need for early diagnosis and management.
Paediatric Nephrology Unit, Department of Paediatrics, Obafemi Awolowo University Teaching Hospitals complex, PMB 5538, Ile-Ife, Osun State, Nigeria.
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Olowu
D000671:Amputation, Surgical; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005734:Gangrene / Q000382:microbiology / Q000601:surgery; D006801:Humans; D011695:IgA Vasculitis / Q000175:diagnosis / Q000378:metabolism / Q000382:microbiology* / Q000628:therapy; D007511:Ischemia / Q000382:microbiology / Q000601:surgery; D007710:Klebsiella Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism; D007711:Klebsiella pneumoniae; D014034:Toes / Q000098:blood supply