Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4.
The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gram-negative bacterial clearance and a dampened response to endotoxin in the skin.
Department of Rheumatology, University Hospital Luebeck and Rheumaklinik Bad Bramstedt, 24576 Bad Bramstedt, Germany.
Philipp H
PH
Reichel
Christine
C
Seemann
Elena
E
Csernok
Jens-M
JM
Schröder
Antje
A
Müller
Wolfgang L
WL
Gross
Hendrik
H
Schultz
D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D004731:Endotoxins / Q000494:pharmacology; D005347:Fibroblasts / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D015847:Interleukin-4 / Q000494:pharmacology*; D008565:Membrane Proteins; D012333:RNA, Messenger / Q000032:analysis; D012867:Skin / Q000166:cytology; D015854:Up-Regulation / Q000187:drug effects
D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D004731:Endotoxins; D008565:Membrane Proteins; D012333:RNA, Messenger; C021623:bactericidal permeability increasing protein; D015847:Interleukin-4