Complexation of butylbenzenes with 2-hydroxypropyl-cyclodextrins in aqueous solution.
The stability constants for the inclusion of butylbenzenes (BBs) with 2-hydroxypropyl-cyclodextrins (2HP-CDs) in aqueous solution have been determined using the static head-space method. The 1:1 stability constants were obtained by this method. For the complexation of BBs by 2HP-alpha-CD, the order of stability constants was n-BB > isoBB > tert-BB. In contrast, the order for complexation of BBs by 2HP-beta-CD was the opposite: tert-BB > isoBB > n-BB. The order of the stability constants by 2HP-gamma-CD was similar to that of 2HP-beta-CD, but the values of the stability constants were not significantly different in the BB types. In addition, the binding effects are discussed in relation to the different alkyl groups of BBs.
College of Pharmacy, Nihon University, Chiba, Japan. ysaito@pha.nihon-u.ac.jp
Yoshihiro
Y
Saito
Kaname
K
Hashizaki
Hiroyuki
H
Taguchi
Naotake
N
Ogawa
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D001555:Benzene Derivatives / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D004785:Environmental Pollutants; D008956:Models, Chemical; D014835:Volatilization; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; D047408:gamma-Cyclodextrins
D001555:Benzene Derivatives; D003505:Cyclodextrins; D004785:Environmental Pollutants; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; D047408:gamma-Cyclodextrins; C479658:hydroxypropyl-alpha-cyclodextrin; C479659:hydroxypropyl-gamma-cyclodextrin; D000073738:2-Hydroxypropyl-beta-cyclodextrin