The genetics of adiponectin.
Adiponectin encoded by the APMI gene is one of the adipocyte-expressed proteins that function in the homeostatic control of glucose, lipid, and energy metabolism. Its dysregulation has been suggested to be involved in disorders covering the metabolic X syndrome, such as insulin resistance, obesity, type 2 diabetes, and coronary artery disease. Recent data present evidence of a genetic modulation of the adiponectin level, and linkage of the 3q27 locus, where the APMI gene lies, with diabetes and features of the metabolic X syndrome playing a putative role of the APMI gene in this syndrome. In this article, we present an overview of the results available to date and discuss positive evidence for a role of genetic variants of the APMI gene and questions that genetic data raise.
CNRS UMR 8090, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue du Docteur Calmette, BP 447, F-59021 Lille, France.
Francis
F
Vasseur
Frédéric
F
Leprêtre
Corinne
C
Lacquemant
Philippe
P
Froguel
D052242:Adiponectin; D000818:Animals; D001161:Arteriosclerosis / Q000235:genetics; D003327:Coronary Disease / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005091:Exons; D017353:Gene Deletion; D014644:Genetic Variation; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D036341:Intercellular Signaling Peptides and Proteins; D007438:Introns; D024821:Metabolic Syndrome / Q000235:genetics; D017354:Point Mutation; D011506:Proteins / Q000235:genetics*
D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins