Synthesis and cytotoxicity of new 3-alkyl-1-(1-methyl-2-phenylethyl)ureas related to ceramide.
A series of new 3-alkyl-1-(1-methyl-2-phenylethyl)ureas related to ceramide was synthesized and evaluated for their in vitro cytotoxic activity against five human tumor cell lines. The urea analogue (2b) of B13 showed comparable or slightly more potent cytotoxic activity as compared to B13, indicating that urea does appear to serve as a bioisostere of amide.
College of Pharmacy, Dongduk Women's University, 23-1 Wolgok-dong, Sungbuk-gu, Seoul 136-714, Korea. sl@dongduk.ac.kr
Sejin
S
Lim
Jae Hark
JH
Ryu
Chaeuk
C
Im
Chul Bu
CB
Yim
D002518:Ceramides / Q000502:physiology*; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D066298:In Vitro Techniques; D007680:Kidney Neoplasms; D007938:Leukemia; D008175:Lung Neoplasms; D008297:Male; D011471:Prostatic Neoplasms; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology
D002518:Ceramides; D014508:Urea