Protein microarrays: meeting analytical challenges for clinical applications.
Protein microarrays, one emerging class of proteomic technologies, have broad applications for discovery and quantitative analysis. A rapidly expanding use of this technology is the acquisition of information about the posttranslational modifications of proteins reflecting the activity state of signal pathways and networks, and is now employed for the analysis of biopsy samples in clinical trial research.
FDA-NCI Clinical Proteomics Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. liottal@mail.nih.gov
Lance A
LA
Liotta
Virginia
V
Espina
Arpita I
AI
Mehta
Valerie
V
Calvert
Kevin
K
Rosenblatt
David
D
Geho
Peter J
PJ
Munson
Lynn
L
Young
Julia
J
Wulfkuhle
Emanuel F
EF
Petricoin
D000818:Animals; D000906:Antibodies; D001709:Biotechnology; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D040081:Protein Array Analysis / Q000379:methods*; D020543:Proteome; D012680:Sensitivity and Specificity; D015398:Signal Transduction
D000906:Antibodies; D020543:Proteome