Antiangiogenic activity of lupeol from Bombax ceiba.
In the search for antiangiogenic agents from medicinal plants used in Vietnam, a methanol extract of the stem barks of Bombax ceiba was found to exhibit a significant antiangiogenic activity on in vitro tube formation of human umbilical venous endothelial cells (HUVEC). Bioactivity-guided fractionation and isolation carried out on this extract afforded lupeol as an active principle. At 50 and 30 microg/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma.
College of Pharmacy, Chungnam National University, Taejon 305-764, Korea.
Young-Jae
YJ
You
Nguyen-Hai
NH
Nam
Yong
Y
Kim
Ki-Hwan
KH
Bae
Byung-Zun
BZ
Ahn
D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D035163:Bombax; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects*; D006801:Humans; D051379:Mice; D009389:Neovascularization, Pathologic / Q000378:metabolism; D053978:Pentacyclic Triterpenes; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects; D000094042:Lupanes
D020533:Angiogenesis Inhibitors; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; D014315:Triterpenes; C010480:lupeol; D000094042:Lupanes