[Cellular and molecular changes of the liver in sepsis and in systemic inflammatory response syndrome (SIRS)].
This paper provides a review on the changes in the molecular and cellular level of the liver during sepsis and systemic immune response syndrome. The different function of the various liver cells and their mediators are analyzed. Dual role of nitric-oxide and carbon-monoxide are discussed followed by an overview about acute phase proteins and heat shock proteins in septic liver. A detailed description is presented on the role of the Toll-like receptors and their signaling pathways in the liver during sepsis and systemic immune response syndrome. Finally, the possible mechanisms leading to apoptosis of the liver cells are shown and the most recent therapeutical challenges are discussed.
Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Sebészeti Klinika, Budapest.
László
L
Romics
György
G
Frendl
Gyöngyi
G
Szabó
D000209:Acute-Phase Proteins / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D002248:Carbon Monoxide / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D008099:Liver / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D009569:Nitric Oxide / Q000378:metabolism; D018805:Sepsis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D018746:Systemic Inflammatory Response Syndrome / Q000276:immunology / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy
D000209:Acute-Phase Proteins; D016207:Cytokines; D006360:Heat-Shock Proteins; D018950:Lipopolysaccharide Receptors; D009569:Nitric Oxide; D002248:Carbon Monoxide