A spontaneous and uneventful pregnancy in a Turner mosaic with previous recurrent miscarriages.
BACKGROUND
Conception without ovum donation is very rare in patients with Turner syndrome, occurring mainly in mosaics, and only a third of these natural pregnancies are associated with normal outcome.


METHODS
A spontaneous pregnancy is described in a Turner mosaic (45,X/46,XX) with normal puberty and nine previous first-trimester miscarriages who had refused ovum donation. She also declined antenatal genetic diagnosis. Pregnancy remained uneventful with frequent surveillance and psychosocial support. She delivered a live boy weighing 3260 g (50(th) percentile) and measuring 48 cm (50(th) percentile) with normal karyotype at term.


CONCLUSIONS
The diagnosis of mosaic Turner syndrome should be considered in women who have recurrent abortion. Pregnancy may have a good outcome in these patients despite the greater likelihood of recurrent miscarriage.
Rizk
Diaa E E
DE
Department of Obstetrics and Gynecology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates. rizk.diaa@uaeu.ac.ae
Deb
Purnima
P
D000022:Abortion, Spontaneous / Q000235:genetics; D000328:Adult; D005260:Female; D006801:Humans; D009030:Mosaicism; D011247:Pregnancy; D011256:Pregnancy Outcome; D014424:Turner Syndrome / Q000235:genetics*