Gnetol as a potent tyrosinase inhibitor from genus Gnetum.
Gnetol (2,3',5',6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine tyrosinase activity. Gnetol (IC50, 4.5 microM) was stronger than kojic acid (IC50, 139 microM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed, melanin biosynthesis in murine B16 melanoma cells.
Ohguchi
Kenji
K
Gifu International Institute of Biotechnology, Mitake, Kani-gun, Gifu 505-0116, Japan. kohguchi@giib.or.jp
Tanaka
Toshiyuki
T
Iliya
Ibrahim
I
Ito
Tetsuro
T
Iinuma
Munekazu
M
Matsumoto
Kenji
K
Akao
Yukihiro
Y
Nozawa
Yoshinori
Y
D000818:Animals; D035684:Gnetum / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008543:Melanins / Q000096:biosynthesis; D008546:Melanoma, Experimental / Q000378:metabolism; D051379:Mice; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D011753:Pyrones / Q000494:pharmacology; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
C476734:2,3',5',6-tetrahydroxy-trans-stilbene; D008543:Melanins; D010455:Peptides; D011753:Pyrones; D013267:Stilbenes; C011890:kojic acid