Brain changes in glaucoma.
There is evidence that glaucomatous damage extends from retinal ganglion cells to vision centers in the brain. In the lateral geniculate nucleus (LGN), the major relay center between the eye and the visual cortex, neurons should undergo degenerative and/or neurochemical changes in magno-, parvo-, and koniocellular pathways conveying motion, red-green, and blue-yellow information, respectively. Furthermore, in both the LGN and visual cortex in glaucoma, changes in metabolic activity are observed. The study of brain changes in glaucoma may provide new insights into the pathobiology of glaucomatous damage and disease progression, and may stimulate new detection and therapeutic strategies to prevent blindness.
Department of Ophthalmology and Vision Sciences, St. Michael's Hospital, University of Toronto, Canada.
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Gupta
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YH
Yücel
D000818:Animals; D017209:Apoptosis; D005829:Geniculate Bodies / Q000473:pathology; D005901:Glaucoma / Q000473:pathology*; D006801:Humans; D009410:Nerve Degeneration / Q000473:pathology*; D009474:Neurons / Q000473:pathology; D009901:Optic Nerve Diseases / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology; D014793:Visual Cortex / Q000473:pathology*; D014795:Visual Pathways / Q000473:pathology*