The complexities of skeletal biology.
For a long time, the skeleton was seen as an amorphous tissue of little biological interest. But such a view ignored the large number of genetic and degenerative diseases affecting this organ. Over the past 15 years, molecular and genetic studies have modified our understanding of skeletal biology. By so doing this progress has affected our understanding of diseases and suggested in many instances new therapeutic opportunities.
Karsenty
Gerard
G
Baylor College of Medicine, Bone Disease Program of Texas, One Baylor Plaza, Houston, Texas 77030, USA. karsenty@bcm.tmc.edu
D001846:Bone Development; D001842:Bone and Bones / Q000166:cytology / Q000196:embryology / Q000473:pathology / Q000502:physiology*; D002454:Cell Differentiation; D006801:Humans