Intrinsic T cell defects in systemic autoimmunity.
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of T cell tolerance to nuclear antigens. Studies in mice and humans have demonstrated that T cells from individuals with lupus are abnormal. Here, we review the known T cell defects in lupus and their possible biochemical nature, genetic causes, and significance for lupus pathogenesis.
Kong
Philip L
PL
Section of Rheumatology, Department of Internal Medicine, and Section of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06520, USA.
Odegard
Jared M
JM
Bouzahzah
Farida
F
Choi
Jin-Young
JY
Eardley
Leah D
LD
Zielinski
Christina E
CE
Craft
Joseph E
JE
D000818:Animals; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*