Choto-san prevents occurrence of stroke and prolongs life span in stroke-prone spontaneously hypertensive rats.
The effects of long-term oral administration of choto-san (diao-teng-san in Chinese) extract on the occurrence of stroke and life span were investigated in stroke-prone spontaneously hypertensive rats (SHR-SPs). Twenty-four rats were ramdomized into three groups. From 8 weeks of age, 0.1% and 0.3% choto-san groups were given water containing 0.1% (150 mg/kg/day) and 0.3% (450 mg/kg/day) choto-san extract, respectively. A control group was given only water. The mean survival times of the control group, 0.1% and 0.3% choto-san groups were 122.1, 159.8 and 176.8 days, respectively. The percent survivals of both the 0.1% and 0.3% choto-san groups were significantly enhanced compared to the control (Kaplan-Meier analysis followed by log-rank test; 0.1% choto-san: p < 0.05; 0.3% choto-san: p < 0.05). Furthermore, the cumulative percent occurrence of neurological and behavioral signs accompying stroke in the 0.3% choto-san group was significantly inhibited compared to the control (p < 0.05). These results suggested that choto-san prevents the occurrence of stroke and prolongs the life span of SHR-SPs.
Shimada
Yutaka
Y
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University 2630 Sugitani, Toyama 930-0194, Japan. shimada@ms.toyama-mpu.ac.jp
Yang
Qiao
Q
Yokoyama
Koichi
K
Goto
Hirozo
H
Kasahara
Yuji
Y
Sekiya
Nobuyasu
N
Hikiami
Hiroaki
H
Terasawa
Katsutoshi
K
D000818:Animals; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006973:Hypertension / Q000150:complications*; D008017:Life Expectancy; D008297:Male; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D020521:Stroke / Q000209:etiology / Q000517:prevention & control*; D014665:Vasodilator Agents / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D014665:Vasodilator Agents; C120250:choto-san