[A study on the expression of VEGF in the blunt injury of rat's skin].
OBJECTIVE
To evaluate changes of VEGF in skin after blunt injury.


METHODS
The rats of injury groups were subjected to skin blunt injury by free-falling iron hammer. The samples taken at 1 h, 3 h, 6 h, 12 h, 1 d, 3 d, 5 d, 7 d, 9 d after injury were studied by immunohistochemistry and MIAS image analysis system.


RESULTS
In the skin of normal control group the expression level of VEGF was low. The increase of VEGF could be observed at 1 day after injury, reached peak at 7 days and declined at 9 days.


CONCLUSIONS
Blunt injury in the skin could induce the expression of the VEGF. Moreover, the change pattern of VEGF level was quite regular with time and could be used to estimate the time after skin injury.
Li
Mei
M
Forensic Pathology Department, School of Legal Medicine, Sichuan University, Chengdu 610041. lmei@163.com
Huang
Pei-jun
PJ
Liu
Min
M
D000818:Animals; D016228:Endothelial Growth Factors / Q000378:metabolism*; D005260:Female; D005554:Forensic Medicine; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008222:Lymphokines / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000293:injuries* / Q000378:metabolism; D013997:Time Factors; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D014949:Wounds, Nonpenetrating / Q000378:metabolism*
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors