Immunohistochemical and ultrastructural study of chordoid glioma of the third ventricle: its tanycytic differentiation.
A chordoid glioma in the third ventricle was studied immunohistochemically and ultrastructurally. In this report, special attention is paid to the histogenesis in relation to the pathological appearance and unique anatomic location of this tumor. Light microscopic and immunohistochemical findings were similar to those reported previously. Ultrastructurally, microvilli were frequently seen, but three types of abnormal cilia were rarely observed. Basement membrane around the tumor cells and microvessels was extensive. Poorly to moderately developed intermediate (adherent) junctions were frequently seen. Resemblance of these ultrastructural features of the tumor to embryonic tanycytes suggests the tanycytic differentiation of chordoid glioma. Neuroradiologically, all of the previously reported cases of chordoid gliomas seem to arise in the anterior part of the third ventricular floor. This region includes the lamina terminalis, infundibular recess and median eminence, which corresponds to a tanycyte-rich area. These findings suggest a tanycytic origin of chordoid glioma.
Department of Neurosurgery, Fukui Medical University, 23 Shimoaizuki, Yoshida-gun, Matsuoka-cho, 910-1193 Fukui, Japan. ksato@fmsrsa.fukui-med.ac.jp
Kazufumi
K
Sato
Toshihiko
T
Kubota
Masaki
M
Ishida
Kazuhiko
K
Yoshida
Hiroaki
H
Takeuchi
Yuji
Y
Handa
D022005:Adherens Junctions / Q000648:ultrastructure; D000368:Aged; D002454:Cell Differentiation; D016545:Choroid Plexus Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure*; D002923:Cilia / Q000648:ultrastructure; D004805:Ependyma / Q000473:pathology; D005260:Female; D005910:Glioma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D008871:Microvilli / Q000648:ultrastructure; D020542:Third Ventricle