Daphniglaucins A and B, novel polycyclic quaternary alkaloids from Daphniphyllum glaucescens.
[structure: see text] Two cytotoxic quaternary Daphniphyllum alkaloids with an unprecedented fused-polycyclic skeleton containing a 1-azoniatetracyclo[5.2.2.0.(1,6)0.(4,9)]undecane ring system, daphniglaucins A (1) and B (2), have been isolated from the leaves of Daphniphyllum glaucescens. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic data.
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. jkobay@pharm.hokudai.ac.jp
Jun'ichi
J
Kobayashi
Hiroshi
H
Takatsu
Ya-Ching
YC
Shen
Hiroshi
H
Morita
D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000302:isolation & purification*; D007564:Japan; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000302:isolation & purification*; D016339:Spectrometry, Mass, Fast Atom Bombardment
D001952:Bridged-Ring Compounds; D010936:Plant Extracts; D011083:Polycyclic Compounds; C476519:daphniglaucin A; C476520:daphniglaucin B