Ovarian ablation in the adjuvant treatment of premenopausal and perimenopausal breast cancer.
BACKGROUND
Ovarian ablation has been employed in the treatment of breast cancer for many decades and, more recently, its value as an adjuvant treatment for premenopausal women with early-stage disease has been clearly demonstrated. This review examines the different methods of achieving ovarian ablation and assesses the relevance of ovarian suppression as a treatment aim.


METHODS
Medline searches were used to identify recent key articles relating to the adenoma-carcinoma sequence. Further relevant articles were obtained by manual scanning of the reference lists of selected papers.


CONCLUSIONS
Ovarian ablation has historically been achieved by surgical or radiological intervention. Although beneficial in premenopausal disease, these methods produce permanent ablation that results in a premature menopause, which may be associated with long-term adverse events. A series of trials have recently demonstrated the benefits of luteinizing hormone releasing hormone (LHRH) agonists, such as goserelin and leuprorelin, as adjuvant treatment for premenopausal hormone-sensitive disease. LHRH agonists produce a reliable suppression of ovarian oestrogen production of equivalent efficacy to adjuvant chemotherapy in hormone-sensitive disease. Effective ovarian suppression is marked by amenorrhoea, but studies have suggested that permanent amenorrhoea is not necessary to confer benefit in the treatment of early breast cancer. LHRH agonists therefore represent a beneficial therapeutic option for premenopausal patients with hormone-sensitive early disease.
University College London, Charles Bell House, 67-73 Riding House Street, London W1P 7LD, UK. r.sainsbury@ucl.ac.uk
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D000328:Adult; D000568:Amenorrhea / Q000209:etiology; D001943:Breast Neoplasms / Q000628:therapy*; D018572:Disease-Free Survival; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods; D010052:Ovariectomy; D010053:Ovary / Q000187:drug effects* / Q000528:radiation effects
D007987:Gonadotropin-Releasing Hormone