Dispatch. GTPase signalling: new functions for Diaphanous-related formins.
The Diaphanous-related formins are effectors for Rho GTPases. Two recent reports have unveiled previously unappreciated activities of Drf3 (mDia2), eliciting cytoskeletal rearrangements at the behest of Cdc42, and of DRF2 (hDia2C), regulating endosome dynamics for RhoD.
Olson
Michael F
MF
Abramson Family Cancer Research Institute, BRB II/III, 421 Curie Blvd. University of Pennsylvania, Philadelphia, PA 19104, USA. molson@mail.med.upenn.edu
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002874:Chromosome Mapping; D004331:Drosophila melanogaster; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D012441:Saccharomyces cerevisiae; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D002352:Carrier Proteins; D020558:GTP Phosphohydrolases; D020741:rho GTP-Binding Proteins