[Cardiomyogenesis in the embryonic period of human development].
The morphological analysis of major processes involved in cardiac myogenesis (including cytodifferentiation, proliferation, integration and apoptosis) was carried out by studying the myocardium of 52 human embryos at weeks 4 to 8 of development. The data provided by this study, permit to draw a conclusion on the coupling of high proliferative activity of cardiomyocytes, their active divergent differentiation, formation of the integrative intercellular communications and manifestations of programmed cell death relations during this period of ontogenesis. Starting with week 6 of intrauterine life, the developing atrial and ventricular cardiac muscular tissue demonstrates the heteromorphy of constituting cardiomyocytes, which differentiate into three types: contractile, contractile-secretory and conducting ("light").
Department of Histology, Cytology and Embryology, Rostov State Medical University, Rostov-on-Don.
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PA
Khloponin
O Iu
OIu
Patiuchenko
D002454:Cell Differentiation / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000502:physiology*; D006321:Heart / Q000196:embryology*; D006801:Humans; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*