[Effect of typical aldehyde pollutants on the DNA damage of spleen lymphocytes of mice].
The DNA damage of spleen lymphocytes induced by three typical aldehyde pollutants was studied in vitro with microgel single cell electrophoresis assay (comet assay). It showed that the comet cells induced by the three chemicals were observed, and the dose-dependent relations were existed. It suggested that the three aldehydes could induce DNA strand breakage.
Institute of Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China.
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Yang
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Zhang
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Li
D000079:Acetaldehyde / Q000633:toxicity*; D000171:Acrolein / Q000633:toxicity*; D000393:Air Pollutants / Q000633:toxicity; D000818:Animals; D002469:Cell Separation; D004249:DNA Damage / Q000187:drug effects*; D004357:Drug Synergism; D005260:Female; D005557:Formaldehyde / Q000633:toxicity*; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D013154:Spleen / Q000166:cytology
D000393:Air Pollutants; D005557:Formaldehyde; D000171:Acrolein; D000079:Acetaldehyde