Synthesis of fluorinated 1-(3-morpholin-4-yl-phenyl)-ethylamines.
The synthesis of four (+/-)-fluorinated 1-(3-morpholin-4-yl-phenyl)-ethylamines and an enantioselective approach to these amines through reductive amination are described.
Department of Neuroscience Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. young-jin.wu@bms.com
Yong-Jin
YJ
Wu
Huan
H
He
Li-Qiang
LQ
Sun
Dedong
D
Wu
Qi
Q
Gao
Hui-Yin
HY
Li
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D005461:Fluorine / Q000737:chemistry; D015394:Molecular Structure; D009025:Morpholines / Q000737:chemistry; D010627:Phenethylamines / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D009025:Morpholines; D010627:Phenethylamines; D005461:Fluorine