Klebsiella-induced purpura fulminans in a Nigerian child: case report and a review of literature.
Purpura fulminans (PPF) is a very severe but rare acute thrombohaemorrhagic illness of infants and young children. It occurs mainly, in patients with either congenital or acquired deficiencies of proteins C and S and antithrombin III. Features of PPF include disseminated intravascular coagulopathy, symmetrical necrotic purpura and/or ecchymoses and symmetrical peripheral gangrene; digital and/ or limb(s) amputations and end-organ failure(s) may also occur. The case of a 3.5 year-old Nigerian girl, who developed PPF following Klebsiella-rhinoscleromatis septicaemia is reported to illustrate the seriousness of the disease and the need for early diagnosis and management.
Olowu
W A
WA
Paediatric Nephrology Unit, Department of Paediatrics, Obafemi Awolowo University Teaching Hospitals complex, PMB 5538, Ile-Ife, Osun State, Nigeria.
D000671:Amputation, Surgical; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005734:Gangrene / Q000382:microbiology / Q000601:surgery; D006801:Humans; D011695:IgA Vasculitis / Q000175:diagnosis / Q000378:metabolism / Q000382:microbiology* / Q000628:therapy; D007511:Ischemia / Q000382:microbiology / Q000601:surgery; D007710:Klebsiella Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism; D007711:Klebsiella pneumoniae; D014034:Toes / Q000098:blood supply