Syntheses, in vitro and in vivo characterization of a 99mTc-(I)-tricarbonyl-benzylamino-dihydroxymethyl phosphine (NP(2)) chelate.
Studies were performed to study the complexation chemistry of 99mTc(CO)(+)(3) with a new tridentate amino-dihydroxymethyl phosphine (NP(2)) ligand with the 99mTc(CO)(3)(OH(2))(+)(3) synthon at tracer levels. A single, well-defined 99mTc(CO)(3)NP(2) complex is formed at pH 7.5 within 10 min at 60 degrees C that exhibits high in vitro and in vivo stability.
Kothari
K K
KK
Radiopharmaceuticals Chemistry Section, Radiopharmaceuticals Division, Bhabha Atomic Center, Mumbai 400085, India. kanchan@apsara.barc.ernet.in
Raghuraman
K
K
Pillarsetty
N K
NK
Hoffman
T J
TJ
Owen
N K
NK
Katti
K V
KV
Volkert
W A
WA
D000818:Animals; D002614:Chelating Agents / Q000737:chemistry; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D051379:Mice; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D010720:Phosphines / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D011868:Radioisotopes; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D014018:Tissue Distribution
D002614:Chelating Agents; D008024:Ligands; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D010720:Phosphines; D011868:Radioisotopes; D019275:Radiopharmaceuticals