[Toxicity of anti-herbicide gene (BAR) transgenic rice].
In order to evaluate the safety of anti-herbicide gene(BAR) transgenic rice, acute toxicity experiments, mutation experiments and a 30-day feeding test were conducted. The results were as follows: The oral LD50 for mice and rats was larger than 21.5 g/kg BW and no mutation was found. The rats consuming 16.32 and 64 g/kg BW were in good growth and development at the 30-day feeding test. The body weight, food utilization, routine blood tests, the ratio of organ weight to body weight, and patho-histological observations had no obvious change. The none effect dosage for the transgene rice was 64 g/kg.
Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
Y
Y
Wang
W
W
Lai
J
J
Chen
S
S
Mei
D000818:Animals; D005260:Female; D006540:Herbicides; D007305:Insecticide Resistance / Q000235:genetics; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009152:Mutagenicity Tests; D012275:Oryza / Q000235:genetics*; D030821:Plants, Genetically Modified / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019076:Transgenes / Q000235:genetics*
D006540:Herbicides