Kernicterus and G6PD deficiency--a case series from Oman.
The relationship between glucose-6 phosphate dehydrogenase (G6PD) deficiency and jaundice in the newborn period is well recognized. However, there is concern about the increasing incidence of kernicterus being reported worldwide, especially due to unrecognized G6PD deficiency and early discharge from hospital after birth. We report a case series of kernicterus from a set-up where the high prevalence rate of G6PD deficiency is known. Fourteen cases of kernicterus were seen during a time period of 6 years, 71 per cent of them had G6PD deficiency. Recent literature is reviewed and possible preventive measures in the light of current information and practices are suggested.
Nair
P Arun Kumar
PA
Department of Child Health, Royal Hospital, Sultanate of Oman. srinavin@omantel.net.om
Al Khusaiby
Saleh Mohammad
SM
D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000150:complications* / Q000175:diagnosis / Q000517:prevention & control; D007647:Kernicterus / Q000209:etiology*; D008297:Male