Trimethylsilyl halide-promoted Michaelis-Arbuzov rearrangement.
[reaction: see text] We describe a new, straightforward, and easy-to-handle method for achieving an unprecedented trimethylsilyl halide-catalyzed Michaelis-Arbuzov-like rearrangement. This rearrangement occurs at temperatures from room temperature to 80 degrees C and does not require addition of any alkyl halide. The scope and limitations of this new reaction are explored, as well as its mechanism.
Renard
Pierre-Yves
PY
Service de Marquage Moléculaire et de Chimie Bioorganique, CEA Saclay, F-91191 Gif sur Yvette Cedex, France. pierre-yves.renard@cea.fr
Vayron
Philippe
P
Mioskowski
Charles
C