Comparison of desipramine or carbamazepine to placebo for crack cocaine-dependent patients.
The authors compared the effects of desipramine or carbamazepine to placebo in an intensive outpatient program for cocaine abuse. Subjects recruited from an urban drug treatment program were randomly assigned to a double-blind, placebo-controlled, eight-week trial of desipramine, carbamazepine, or placebo. Patient ratings, urine drug screens, and blood samples were obtained weekly. Using survival analysis, the three groups did not differ in time to drop out of treatment. While subjects improved over time on all self-ratings related to cocaine use, mood, and craving, only two items related to mood were significantly different over time as a function of treatment group. Subjects in the two treated groups reported significantly more improvement on self-ratings of depression and irritability. No treatment differences were noted for sustained abstinence or for proportion of positive urine drug screens. Desipramine subjects who attained a minimum blood level were retained in treatment significantly longer than placebo or other non-compliant treatment groups. This finding supports previous reports of a possible role for desipramine in cocaine abuse treatment.
Department of Psychiatry and Behavioral Sciences, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. jcampbell@kc.rr.com
Jan
J
Campbell
Elizabeth J
EJ
Nickel
Elizabeth C
EC
Penick
Dennis
D
Wallace
William F
WF
Gabrielli
Carolyn
C
Rowe
Barry
B
Liskow
Barbara J
BJ
Powell
H Mikel
HM
Thomas
D000328:Adult; D000927:Anticonvulsants / Q000097:blood / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000097:blood / Q000627:therapeutic use*; D002220:Carbamazepine / Q000097:blood / Q000627:therapeutic use*; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000652:urine; D016578:Crack Cocaine / Q000652:urine; D003863:Depression; D003891:Desipramine / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007508:Irritable Mood; D008297:Male; D010352:Patient Dropouts; D010919:Placebos; D012647:Self-Assessment; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
D000927:Anticonvulsants; D000929:Antidepressive Agents, Tricyclic; D016578:Crack Cocaine; D010919:Placebos; D002220:Carbamazepine; D003891:Desipramine