Studies on the role of some synthetic curcuminoid derivatives in the inhibition of tumour specific angiogenesis.
In this study, some of the synthetic curcuminoid derivatives are analyzed for their anti-angiogenic activity. Intraperitoneal administration of the compounds tetrahydrocurcumin (THC), salicyl curcumin (SC) and curcuminIII (C-III) reduced the number of tumour directed capillaries induced by injecting B16F-10 melanoma cells on the ventral side of C57BL/6 mice. THC (14.5 +/- 2.5 capillaries) and SC (16 +/- 2.5 capillaries) were more significant (P < 0.001) than C-III (19 +/- 1.8 capillaries) compared to the untreated control (30.8 +/- 2.1 capillaries). Treatment with these curcuminoids reduced the serum NO as well as TNF-alpha levels of the angiogenesis-induced animals. In vitro NO and TNF-alpha production by the activated MOs were reduced in a concentration dependent manner by the treatment of the curcuminoid compounds.
Amala Cancer Research Centre, Thrissur, India.
P V
PV
Leyon
G
G
Kuttan
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D002196:Capillaries / Q000187:drug effects / Q000473:pathology; D003474:Curcumin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008546:Melanoma, Experimental / Q000098:blood supply*; D051379:Mice; D008810:Mice, Inbred C57BL; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D009569:Nitric Oxide / Q000378:metabolism; D008517:Phytotherapy; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D020533:Angiogenesis Inhibitors; D014409:Tumor Necrosis Factor-alpha; C096277:tetrahydrocurcumin; D009569:Nitric Oxide; C475935:curcumin III; D003474:Curcumin