Dopamine D2 receptor TaqIA and TaqIB polymorphisms in Parkinson's disease.
In a case control study, we examined the association of DRD2 Taq1A and Taq1B polymorphisms and risk of PD, and evaluated the strength of linkage disequilibrium of the polymorphisms. The Taq1A and Taq1B polymorphisms were in strong linkage disequilibrium. There was, however, no significant association of the two polymorphisms with PD.
Tan
Eng-King
EK
Department of Neurology, Singapore General Hospital, Singapore. gnrtek@sgh.com.sg
Tan
Yanni
Y
Chai
Anthea
A
Tan
Christopher
C
Shen
Hui
H
Lum
Sau-Ying
SY
Fook-Cheong
Stephanie M C
SM
Teoh
Mei-Ling
ML
Yih
Yuan
Y
Wong
Meng-Cheong
MC
Zhao
Yi
Y
D000483:Alleles; D000704:Analysis of Variance; D017931:DNA Primers / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D019914:Taq Polymerase / Q000145:classification / Q000235:genetics*
D017931:DNA Primers; D005819:Genetic Markers; D017448:Receptors, Dopamine D2; D019914:Taq Polymerase