The effect of dexamethasone on the longevity of syringe driver subcutaneous sites in palliative care patients.
OBJECTIVE
To assess the effect of adding 1 mg dexamethasone to syringe drivers on the viability time of subcutaneous cannulation sites in palliative care patients.


METHODS
Prospective, double-blind, randomised, controlled trial in which patients received half their daily infused medications plus 1 mg dexamethasone in 1 mL saline through one subcutaneous site (test site) and the other half of their medications plus 1 mL saline through another symmetrically placed site (control site).


METHODS
Palliative care patients from the inpatient units at two hospices, recruited between 1999 and 2002.


METHODS
Difference in time that the test and control sites remained viable.


RESULTS
38 patients consented and were randomised. Twenty did not complete the trial because their participation in the study finished before either site broke down. Eighteen patients either partially completed (at least one site broke down) or fully completed (both sites broke down) the trial. In these 18 patients, test sites lasted 3.6 days longer than control sites (95% CI, 1.5-5.8 days; P = 0.002). Twelve patients fully completed the trial. In this group, test sites lasted 3.9 days longer than control sites (95% CI, 0.6-7.2 days; P = 0.025).


CONCLUSIONS
The addition of 1 mg dexamethasone to syringe drivers significantly extends the viability time of subcutaneous cannulation sites in palliative care patients.
Reymond
Liz
L
Mount Olivet Hospice, 411 Main Street, Kangaroo Point, Queensland 4169, Australia. lreymond@uq.net.au
Charles
Margaret A
MA
Bowman
Jan
J
Treston
Pat
P
D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects; D003907:Dexamethasone / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous / Q000009:adverse effects / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*; D010166:Palliative Care; D011446:Prospective Studies; D013594:Syringes
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone