Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study.
BACKGROUND
There is growing evidence that schizophrenia is a disorder of cortical connectivity. Specifically, frontotemporal and frontoparietal connections are thought to be functionally impaired. Diffusion tensor magnetic resonance imaging (DT-MRI) is a technique that has the potential to demonstrate structural disconnectivity in schizophrenia.


OBJECTIVE
To investigate the structural integrity of frontotemporal and frontoparietal white matter tracts in schizophrenia.


METHODS
Thirty patients with DSM-IV schizophrenia and thirty matched control subjects underwent DT-MRI and structural MRI. Fractional anisotropy - an index of the integrity of white matter tracts - was determined in the uncinate fasciculus, the anterior cingulum and the arcuate fasciculus and analysed using voxel-based morphometry.


RESULTS
There was reduced fractional anisotropy in the left uncinate fasciculus and left arcuate fasciculus in patients with schizophrenia compared with controls.


CONCLUSIONS
The findings of reduced white matter tract integrity in the left uncinate fasciculus and left arcuate fasciculus suggest that there is frontotemporal and frontoparietal structural disconnectivity in schizophrenia.
Department of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, UK.
J
J
Burns
D
D
Job
M E
ME
Bastin
H
H
Whalley
T
T
Macgillivray
E C
EC
Johnstone
S M
SM
Lawrie
D016880:Anisotropy; D001931:Brain Mapping / Q000379:methods; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D009434:Neural Pathways / Q000473:pathology*; D012559:Schizophrenia / Q000473:pathology*