Synthesis of metal-chelating lipids to sensitize lanthanide ions.
Sensitization of lanthanide ions is important for lanthanide ion-based assays and sensing. To the best of our knowledge, there are very few reports of lanthanide ion sensitization after it is incorporated into the liposome surface. This paper describes the syntheses of several saturated and polymerizable metal-chelating lipids based on chelidamic acid. The lipids are synthesized either from (S)-ornithine or racemic 2,3-diaminopropanoic acid. These lipids as well as polymerized liposomes incorporating these lipids sensitize lanthanide ions. Liposomes from the lipid 18-Eu(3+) provided a probe that relies not only on the emission wavelengths of Eu(3+) but also on a reproducible lifetime that can be used for protein identification.
Roy
Bidhan C
BC
Department of Chemistry, North Dakota State University, Fargo 58105, USA.
Santos
Marina
M
Mallik
Sanku
S
Campiglia
Andres D
AD
D002384:Catalysis; D002614:Chelating Agents / Q000138:chemical synthesis*; D005063:Europium / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D007554:Isotopes; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008055:Lipids / Q000138:chemical synthesis*; D008081:Liposomes / Q000138:chemical synthesis*; D015394:Molecular Structure; D013050:Spectrometry, Fluorescence
D002614:Chelating Agents; D005456:Fluorescent Dyes; D007202:Indicators and Reagents; D007554:Isotopes; D028581:Lanthanoid Series Elements; D008055:Lipids; D008081:Liposomes; D005063:Europium