No inverse association between fish consumption and risk of death from all-causes, and incidence of coronary heart disease in middle-aged, Danish adults.
This study investigate the relation between fish consumption, all-cause mortality, and incidence of coronary heart disease (CHD). A total of 4,513 men and 3,984 women aged 30-70 years, sampled randomly from the population in Copenhagen County, Denmark, with initially examination in 1982-1992 was followed until 2000 for all-cause mortality and until 1997 for first admission to hospital or death from CHD. Information on fish consumption was obtained from a self-administered food-frequency questionnaire. Cox proportional hazard analysis gave no evidence for an inverse association between fish consumption and all-cause mortality or incident CHD after adjustment for confounders. Among subjects with a priory-defined high risk of CHD there was a nonsignificant inverse relation between fish intake and CHD morbidity (Hazard Ratio 1.28 (0.92-1.80) for a consumption of fish of less than two times per month or less compared with once a week), but there was relatively few cases in this subgroup. These data provides no evidence for a protective effect of fish consumption on all-cause mortality or incident CHD in the population as a whole, but it cannot be excluded that frequent consumption of fish benefits those at high risk for CHD.
Osler
Merete
M
Institute of Public Health, University of Copenhagen, Panum Institute, Blegdamsvej 3, 2200 Copenhagen N, Denmark. M.Osler@socmed.ku.dk
Andreasen
Anne Helms
AH
Hoidrup
Susanne
S
D000328:Adult; D000368:Aged; D000818:Animals; D002423:Cause of Death; D003327:Coronary Disease / Q000453:epidemiology* / Q000517:prevention & control; D003718:Denmark / Q000453:epidemiology; D004032:Diet; D005260:Female; D005399:Fishes; D005500:Follow-Up Studies; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012307:Risk Factors