Correlation between gel structural properties and drug release pattern in scleroglucan matrices.
The drug delivery behavior of scleroglucan hydrogels was correlated with the structural features found by means of steady-state fluorescence studies. Theophylline at 0.4% in weight was used as the model drug and its release was measured using a Franz cell device. The results were fitted with a semi-empirical power law equation, finding significant differences between the 0.5% and higher than 0.8% scleroglucan concentrations (w/w). Four molecular fluorescent probes were used to test microenvironmental properties of the gel cavities, which will play a key role on the release of the pharmaceutical drugs. The results found by the fluorescence analysis are in good agreement with the ones obtained by release kinetics.
Daraio
Marta E
ME
Laboratorio de Química de Sistemas Heterogéneos, Facultad de Ingeniería, Universidad de Buenos Aires, Buenos Aires, Argentina.
François
Nora
N
Bernik
Delia L
DL
D000180:Acrylic Resins; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics*; D005454:Fluorescence Polarization / Q000379:methods; D005456:Fluorescent Dyes; D005936:Glucans / Q000737:chemistry* / Q000493:pharmacokinetics*; D020100:Hydrogels / Q000737:chemistry* / Q000493:pharmacokinetics*; D004364:Pharmaceutical Preparations; D011145:Polyvinyls / Q000493:pharmacokinetics; D013806:Theophylline / Q000493:pharmacokinetics
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D005456:Fluorescent Dyes; D005936:Glucans; D020100:Hydrogels; D004364:Pharmaceutical Preparations; D011145:Polyvinyls; C006912:carboxypolymethylene; C045938:scleroglucan; D013806:Theophylline