Detection of circulating Aspergillus fumigatus galactomannan: value and limits of the Platelia test for diagnosing invasive aspergillosis.
The effectiveness of galactomannan detection with the Platelia test was evaluated in a prospective study of 3,327 sera from 807 patients. The specificity was 99.6% (748 of 751 cases). For the groups of patients with proven and probable invasive aspergillosis, the sensitivity was 50.0% (17 of 34 cases). The disappointing sensitivity associated with the presence of rare false-positive cases underlines the limits of this test.
Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire, 38043 Grenoble, France. CPinel@chu-grenoble.fr
Claudine
C
Pinel
Hélène
H
Fricker-Hidalgo
Bernadette
B
Lebeau
Frédéric
F
Garban
Rébecca
R
Hamidfar
Pierre
P
Ambroise-Thomas
Renée
R
Grillot
D000368:Aged; D000946:Antigens, Fungal / Q000097:blood; D001228:Aspergillosis / Q000175:diagnosis* / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000276:immunology / Q000302:isolation & purification*; D002648:Child; D005189:False Positive Reactions; D005260:Female; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D008351:Mannans / Q000097:blood* / Q000276:immunology; D009172:Mycology / Q000379:methods* / Q000706:statistics & numerical data; D011446:Prospective Studies; D012680:Sensitivity and Specificity
D000946:Antigens, Fungal; D008351:Mannans; C012990:galactomannan; D005690:Galactose