Condyloma acuminatum and human papilloma virus infection in the oral mucosa of children.
OBJECTIVE
The purpose of this study was to investigate the clinicopathological features of oral condylomas in children and condylomatous lesions of their mothers. Moreover, the authors sought to determine the mode of transmission of this disease and to find the genotype of human papilloma virus (HPV) in the children's oral condyloma.


METHODS
Nine instances of oral condyloma acuminatum in children and lesions in their mothers were reviewed. Their HPV genotypes were evaluated by in situ hybridization (ISH).


RESULTS
This study revealed that the lesions appeared during 3 years of age and the most common location was the hard and soft palate. Seven of the 9 mothers had experienced vulva and/or oral cavity condylomata during pregnancy. Social evaluation confirmed sexual abuse in 1 girl, and probable sexual abuse in another girl. The results of ISH demonstrated HPV 16/18 DNA being positive in 5 of the 9 cases, and HPV 6 and HPV 11, HPV 6 and HPV 16/18, HPV 6, and HPV 11 DNA being positive, respectively, in 1 case. HPV DNA types in mother-child pairs were not concordant.


CONCLUSIONS
Oral condyloma acuminatum in children is probably induced by HPV 16/18. The mode of transmission by sexual abuse is the most likely route. Prenatal transmission of HPV to children is rare. This study provides further confirmation of possible different genotype and transmission in oral CA of children and adults.
Department of Oral Pathology, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, The People's Republic of China. laikuiliu@sina.com
Liu Lai
LL
Kui
He Zhi
HZ
Xiu
Li Yi
LY
Ning
D000328:Adult; D002648:Child; D002650:Child Abuse, Sexual; D002675:Child, Preschool; D003218:Condylomata Acuminata / Q000209:etiology / Q000473:pathology* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D018562:Disease Transmission, Infectious; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D009035:Mothers; D009059:Mouth Diseases / Q000209:etiology / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000635:transmission*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious
D004279:DNA, Viral