Resolution of ephedrine stones with dissolution therapy.
A patient with a history of ingesting large quantities of an over-the-counter stimulant developed renal calculi that on further analysis, after stone passage, revealed increased amounts of ephedrine. Over the course of 7 months, all of the patient's ephedrine stones were managed successfully by alkalinization. Similar to previously reported ephedrine calculi, these stones were radiolucent on x-ray imaging, but their course was monitored on serial nonenhanced computed tomography scans. We believe this to be the first reported use of alkaline therapy for the dissolution of renal stones containing ephedrine.
Department of Urologic Surgery, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
Nathan
N
Hoffman
Shawn M
SM
McGee
John C
JC
Hulbert
D000328:Adult; D002137:Calculi / Q000737:chemistry; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000378:metabolism; D004334:Drug Administration Schedule; D004809:Ephedrine / Q000009:adverse effects* / Q000032:analysis / Q000378:metabolism*; D006140:Guaifenesin / Q000009:adverse effects / Q000032:analysis / Q000378:metabolism; D006801:Humans; D007669:Kidney Calculi / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D004366:Nonprescription Drugs / Q000009:adverse effects* / Q000378:metabolism*; D019357:Potassium Citrate / Q000627:therapeutic use; D016896:Treatment Outcome
D000697:Central Nervous System Stimulants; D004366:Nonprescription Drugs; D006140:Guaifenesin; D019357:Potassium Citrate; D004809:Ephedrine