Evaluation of feline serum amyloid A (SAA) as an inflammatory marker.
The concentration of feline serum amyloid A (fSAA) was determined by a direct enzyme-linked immunosorbent assay (ELISA) by using fSAA specific monoclonal antibodies, to evaluate the fSAA as an inflammatory marker in cats. The mean concentration +/- standard deviation of fSAA was found to be 0.60 +/- 1.06 microg/m l and 33.65 +/- 67.59 microg/ml in serum samples from normal cats (n=45) and cats (n=312) with various diseases and disorders, respectively. A significant difference (p<0.001) was found between the two groups. It was also found that the concentration of fSAA begins to increase rapidly at approximately 3-6 hr after spay, and increases up to significantly high levels in some disorders, like injury, renal failure, infectious diseases, etc.
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yoshida, Japan.
Kimikazu
K
Sasaki
Zhiyong
Z
Ma
Tanvir S
TS
Khatlani
Masaru
M
Okuda
Hisashi
H
Inokuma
Takafumi
T
Onishi
D000818:Animals; D000911:Antibodies, Monoclonal; D015415:Biomarkers / Q000097:blood; D002371:Cat Diseases / Q000097:blood / Q000175:diagnosis*; D002415:Cats; D003141:Communicable Diseases / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D004751:Enteritis / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D009059:Mouth Diseases / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D051437:Renal Insufficiency / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D000685:Serum Amyloid A Protein / Q000032:analysis* / Q000276:immunology; D014570:Urologic Diseases / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D014947:Wounds and Injuries / Q000097:blood / Q000175:diagnosis / Q000662:veterinary
D000911:Antibodies, Monoclonal; D015415:Biomarkers; D000685:Serum Amyloid A Protein