[Effects of sodium selenite on the activity of GSH-Px and the life-span of Drosophila].
In order to investigate the effects of sodium selenite on the activity of glutathione peroxidase and the life-span of drosophila melanogaster, newly enclosed flies were divided randomly into 4 groups and fed with mediums containing different concentrations of sodium selenite. The activity of GSH-Px was determined by 5,5'-dithionbis (2-nitrobenzoic acid) (DTNB) photometric method. The life-span of drosophila was calculated after survival test. The results showed that the activity of GSH-Px in the female and male flies were increased by the increase of sodium selenite in the medium (P < 0.05). The average life-span and the average maximum life-span of flies in selenium groups were increased significantly as compared with control group (P < 0.05). The response of GSH-Px activity and life-span of male flies to selenium intake was better than that of females.
Medical College, Shanghai Tiedao University, Shanghai 200070, China.
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Zhang
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Wang
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Bai
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Li
D000818:Animals; D004331:Drosophila melanogaster; D005979:Glutathione Peroxidase / Q000378:metabolism*; D008136:Longevity / Q000187:drug effects*; D011897:Random Allocation; D018038:Sodium Selenite / Q000494:pharmacology*
D005979:Glutathione Peroxidase; D018038:Sodium Selenite