Trypanosoma cruzi clonal diversity and the epidemiology of Chagas' disease.
Chagas' disease is caused by the protozoan Trypanosoma cruzi and it has a variable clinical outcome. The basis for this variability relies in part on the complexity of the parasite population consisting of multiple clones displaying distinct biological properties. A major current challenge is to correlate parasite genetic variability with pathogenesis.
Buscaglia
Carlos A
CA
Michael Heidelberg Division of Immunology, Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. busac01@med.nyu.edu
Di Noia
Javier M
JM
D000818:Animals; D014355:Chagas Disease / Q000453:epidemiology* / Q000469:parasitology; D014644:Genetic Variation; D006801:Humans; D014349:Trypanosoma cruzi / Q000145:classification* / Q000235:genetics* / Q000472:pathogenicity