[Diagnosis of bone micrometastases in non-small cell lung carcinoma--initial results].
The objective was to elaborate a method of immunohistochemical diagnosis of bone micrometastases and to apply this procedure in operated patients with the non-small cell form of lung cancer. By means of a cocktail of cytokeratin mixtures and individual cytokeratins the immunohistochemical profile of the primary pulmonary focus is assessed. Bone micrometastases are evaluated from the bone marrow of a sampled costal segment. A total of 30 bone marrow samples were examined. For further evaluation 17 patients remained in the group. Isolated segments with a marked positivity of cytokeratins were observed in four instances. The yield of bone marrow from costal segment is very good. The initial results are encouraging for further research.
Chirurgická klinika Masarykovy univerzity, Fakultní nemocnice u svaté Anny v Brnĕ. ivan.capov@fnusa.cz
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D014408:Biomarkers, Tumor / Q000032:analysis; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000556:secondary*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008175:Lung Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor; D007633:Keratins