Highly efficient Lewis acid-catalysed Pictet-Spengler reactions discovered by parallel screening.
High yielding Lewis acid-catalysed one-pot Pictet-Spengler reactions of tryptophan methyl ester and tryptamine with aliphatic and aromatic aldehydes were achieved in short reaction times with the aid of microwave irradiation.
Srinivasan
Natarajan
N
Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Southampton, United Kingdom SO17 1BJ.
Ganesan
A
A