Studies on gynaecological hydrophilic lactic acid preparations. Part 5: The use of Eudragit E-100 as lactic acid carrier in intravaginal tablets.
Intravaginal tablets based on hydrophilic methylcellulose and containing lactic acid complexed with Eudragit E-100 undergo deformation under standard conditions. The high flow--limit of gel originating from the tablets as well as its dynamic viscosity should enable durability of this dosage form on the vaginal mucosa. By selecting either 1 : 1 or 2 : 1 ratios of lactic acid to Eudragit E-100 it is possible to obtain tablets that disintegrate into a gelform at pH 3.8-4.4, i.e. the pH remains within the physiological range. Increasing the amount of lactic acid in the complex in relation to the polymer to a 4:1 ratio results in gels with a lower pH while possessing an acid reserve that can neutralize the excess of alkali present in severe vaginal infections.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University, Wrocław, Poland.
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Małolepsza-Jarmołowska
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Kubis
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Hirnle
D000282:Administration, Intravaginal; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004337:Drug Carriers; D005079:Excipients; D005780:Gelatin; D005782:Gels; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D008689:Methacrylates; D008747:Methylcellulose; D008768:Methylmethacrylates; D013488:Suppositories; D014783:Viscosity
D004337:Drug Carriers; D005079:Excipients; D005782:Gels; D008689:Methacrylates; D008768:Methylmethacrylates; D013488:Suppositories; C102808:Eudragit-E; D019344:Lactic Acid; D005780:Gelatin; D008747:Methylcellulose