Effect of diazinon and/or praziquantel on selected protein aspects in healthy and Schistosoma mansoni infected mice.
In Egypt, schistosomiasis is still a major public health problem and praziquantel is the drug of choice for its treatment, whereas diazinon is globally used as an insecticide for controlling pests. They adversely affect the environment. Therefore, the authors studied the effect of 1/20 LD50 diazinon given orally to healthy and Schistosoma mansoni infected mice for 5 successive days up to 9 and 17 weeks coupled with a therapeutic dose (2 x 500 mg/kg Bwt) of praziquantel, 2 weeks before sacrificing. The results showed that non significant differences were obtained from total proteins, albumin, globulins, and albumin/globulin ratio. However, significant differences were revealed from alpha1-, alpha2-, beta1-, beta2-, and gamma-globubins in addition to plasma ceruloplasmin. Diazinon changed the levels of alpha2-, beta1-, and gamma-globubins, while diazinon coupled with schistosomiasis affected the levels of most studied parameters. Consequently, exposure to insecticides should be avoided specially in the rural areas where schistosomiasis is still endemic.
Department of Applied Biology, Radioisotope Application Division, Nuclear Research Center, Atomic Energy Authority, Faculty of Science, Ain Shams University, Cairo, Egypt.
Laila S
LS
Hanna
Amina M
AM
Medhat
Hanan A
HA
Abdel-Menem
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D001798:Blood Proteins / Q000032:analysis*; D003976:Diazinon / Q000008:administration & dosage / Q000009:adverse effects*; D004347:Drug Interactions; D006262:Health; D007306:Insecticides / Q000008:administration & dosage / Q000009:adverse effects*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011223:Praziquantel / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D012550:Schistosoma mansoni / Q000502:physiology*; D012555:Schistosomiasis mansoni / Q000097:blood* / Q000188:drug therapy* / Q000469:parasitology
D000871:Anthelmintics; D001798:Blood Proteins; D007306:Insecticides; D011223:Praziquantel; D003976:Diazinon