Genetic instability, DNA damage and atherosclerosis.
We review the role of somatic mutations and genetic instability in the pathogenesis of atherosclerosis, suggesting novel therapeutic approaches.
CNR Institute of Clinical Physiology, G. Pasquinucci Hospital, Via Aurelia Sud-Montepepe, 54100 Massa, Italy. andreas@ifc.pi.cnr.it
Maria Grazia
MG
Andreassi
Nicoletta
N
Botto
D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D002455:Cell Division / Q000235:genetics*; D004249:DNA Damage / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D006984:Hypertrophy / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D007249:Inflammation / Q000235:genetics*; D008077:Lipoproteins, LDL / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism*; D009154:Mutation / Q000187:drug effects / Q000235:genetics; D018384:Oxidative Stress / Q000187:drug effects / Q000235:genetics
D008077:Lipoproteins, LDL