Excitement reduces inhibition via endocannabinoids.
Previous work has suggested a role for retrograde synaptic signaling via endogenous cannabinoids in regulating the inhibitory control of neuronal activity. In this issue of Neuron, Chevaleyre and Castillo provide evidence for another form of endocannabinoid-mediated depression of hippocampal inhibition, which is activity dependent and long lasting.
Freund
Tamás F
TF
Department of Functional Neuroanatomy, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1450, Budapest, Hungary.
Hájos
Norbert
N
D000818:Animals; D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D017729:Presynaptic Terminals / Q000378:metabolism*; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D005231:Fatty Acids, Unsaturated; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D017470:Receptors, Glutamate; D005680:gamma-Aminobutyric Acid