A risk for early-onset Alzheimer's disease associated with the APBB1 gene (FE65) intron 13 polymorphism.
Alzheimer's disease (AD) is a genetically complex neurodegenerative disorder and the leading cause of dementia of the elderly. Recently, Hu et al. suggested that a trinucleotide deletion in intron 13 of the APBB1 gene was a factor protecting against late-onset AD. We report here the results of a case/control study aimed at replicating this association. Our study included 461 AD patients and 397 matched controls. We compared the allele and genotype frequencies of the polymorphism between the two groups but did not find any statistically significant difference (P=0.08 and P=0.09, respectively). By contrast, adjusting for age and sex, we found a slight risk associated with the deletion (odds ratio=1.47, 95% confidence interval=1.05-2.04). Stratification by age showed that the risk effect associated with the deletion concerned subjects aged less than 65 years.
Aventis Pharma, Evry Genetics Center & Neurodegenerative Disease Group, Paris Research Center, 13 Quai Jules Guesde, 94400, Vitry-sur-Seine, France.
Emmanuelle
E
Cousin
Didier
D
Hannequin
Sylvain
S
Ricard
Sandrine
S
Macé
Emmanuelle
E
Génin
Céline
C
Chansac
Alexis
A
Brice
Bruno
B
Dubois
Thierry
T
Frebourg
Luc
L
Mercken
Jesus
J
Benavides
Laurent
L
Pradier
Dominique
D
Campion
Jean François
JF
Deleuze
D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D007438:Introns; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012737:Sex Factors
C091042:APBB1 protein, human; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins