Activation-induced cytidine deaminase links class switch recombination and somatic hypermutation.
Activation-induced cytidine deaminase (AID), a putative RNA-editing cytidine deaiminase that is expressed strictly in activated B cells, is indispensable in three apparently distinct genetic alterations of immunoglobulin genes-namely, class switch recombination, somatic hypermutation, and gene conversion. Recent findings led us to propose a common DNA cleaving mechanism, in which the transient secondary structure of the S and V region DNA is recognized by a nicking enzyme regulated by the putative RNA-editing activity of AID.
Okazaki
Ilmi
I
Department of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Yoshikawa
Kiyotsugu
K
Kinoshita
Kazou
K
Muramatsu
Masamichi
M
Nagaoka
Hitoshi
H
Honjo
Tasaku
T
D002460:Cell Line; D003564:Cytidine Deaminase / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D004789:Enzyme Activation; D004790:Enzyme Induction; D008954:Models, Biological; D009154:Mutation; D011995:Recombination, Genetic; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase