Early origins of allergic disease: a review of processes and influences during early immune development.
OBJECTIVE
With the disturbing increase in allergic disease, there is a pressing need to determine the causes, pathogenesis and safe avenues for disease prevention. Although events in early life appear important, no causal pathways have been identified. This review examines new developments in the area of foetal and early postnatal immune maturation. It secondly addresses early predisposing influences and protective factors that may have a future role in allergy prevention.


RESULTS
New developments in the understanding of the ontogeny of allergen-specific immune responses in atopic infants are discussed, including the role of early type 1 and 2 immune responses, and how these are influenced by perinatal antigen presenting cell and T-cell immaturity. The controversial role of early dietary exposures including breastfeeding, food allergens, hydrolyzed formulae and other dietary factors including omega-3 fatty acids are discussed in the context of the most recent literature. Equally contentious, the role of early house dust and pet allergen exposure is discussed in light of new epidemiological studies and disappointing early results of multicentre allergen avoidance studies. Finally, a number of studies in animals and humans suggest that bacterial products can influence early immune development, providing a new potential therapeutic avenue for disease treatment and prevention.


CONCLUSIONS
Complex multifactorial genetic and environmental interactions make research in this area difficult and apparent associations with allergic disease may not be causal in nature. Many current targets for prevention, such as early allergen exposure and infant feeding practices, are proving to be ineffective and may not be directly implicated in rising rates of disease.
Department of Paediatrics, University of Western Australia, Perth, Western Australia, Australia. susanp@ichr.uwa.edu.au
Susan L
SL
Prescott
D002657:Child Development; D005314:Embryonic and Fetal Development; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000473:pathology* / Q000517:prevention & control; D007107:Immune System / Q000196:embryology / Q000254:growth & development; D007223:Infant; D007229:Infant Welfare; D007231:Infant, Newborn; D013997:Time Factors