Treatment of calcium channel blocker intoxication with insulin infusion: case report and literature review.
We present a case report of successful treatment of shock induced by the calcium channel blocker (CCB) diltiazem. A 75-year-old woman took a combination of tablets, including diltiazem. Soon after arrival, she developed haemodynamic shock which persisted despite treatment with fluids, dopamine, dobutamine, norepinephrine (noradrenaline), calcium gluconate and glucagon. Haemodynamic stability was not achieved until an insulin infusion and glucose administration was started. We review the literature and the updated guidelines for the treatment of CCB intoxication, with particular emphasis on situations where insulin and glucose infusions can be live saving.
Internal Medicine Resident, Serviço de Medicina 2-B, Hospital Geral de Santo António, Largo Prof. Abel Salazar, 4099-001 Oporto, Portugal.
Maria
M
Marques
Ernestina
E
Gomes
Júlio
J
de Oliveira
D000368:Aged; D002121:Calcium Channel Blockers / Q000506:poisoning*; D004110:Diltiazem / Q000506:poisoning*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007022:Hypotension / Q000188:drug therapy* / Q000209:etiology; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy
D002121:Calcium Channel Blockers; D007004:Hypoglycemic Agents; D007328:Insulin; D004110:Diltiazem