Computational fluid dynamics simulation of airflow and aerosol deposition in human lungs.
Computational fluid dynamics (CFD) simulations of airflow and particle deposition in geometries representing the human tracheobronchial tree were conducted. Two geometries were used in this work: (1) based on the Weibel A model, and (2) based on a CT scan of a cadaver lung cast. Flow conditions used included both steady-state inhalation and exhalation conditions as well as time-dependent breathing cycles. Particle trajectories were calculated in each of these models by solving the equations of motion of the particle for the deterministic portion of particle displacement, and adding a stochastic Brownian term at each step. The trapping of particles on the wall surfaces was monitored, and the locations of trapping in each generation were recorded. The results indicate that there are dramatic differences in the predicted deposition between the two models. The intragenerational deposition locations show that in regions where the deposition mechanism is inertial impaction, the predominant deposition seems to be at the airway bifurcations. The results of this study suggest that under most conditions, an idealized model based on the Weibel dimensions is not sufficient to predict deposition, and an accurate model, such as those based on imaging techniques may be required.
Nowak
Natalya
N
Chemical Engineering Department, Applied Biomedical Engineering Program, Cleveland State University and The Cleveland Clinic Foundation, 1960 E. 24th Street, Stilwell Hall 462, Cleveland, OH 44115, USA.
Kakade
Prashant P
PP
Annapragada
Ananth V
AV
D000280:Administration, Inhalation; D000336:Aerosols / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001980:Bronchi / Q000378:metabolism / Q000502:physiology*; D001995:Bronchography; D002102:Cadaver; D003198:Computer Simulation; D020342:Finite Element Analysis; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000502:physiology; D008954:Models, Biological; D010316:Particle Size; D012123:Pulmonary Ventilation / Q000502:physiology; D012143:Respiratory Physiological Phenomena; D015657:Respiratory Transport / Q000502:physiology; D012212:Rheology / Q000379:methods*; D014132:Trachea / Q000000981:diagnostic imaging / Q000378:metabolism / Q000502:physiology*
D000336:Aerosols