Evolution, biochemistry and genetics of protein kinase C in fungi.
From yeast to humans, protein kinase C is an enzyme of central importance in signal transduction processes. In baker's yeast, Saccharomyces cerevisiae, a single gene encoding Pkc1p has been identified. Mutant analyses revealed that Pkc1p function is essential to ensure cellular integrity through regulation of a specific MAP kinase cascade. Due to the involvement of different defective mammalian isozymes in various diseases and the model character of simple eukaryotes, increasing attention has been paid to the structure and regulation of the enzymes of fungal origin. This review summarizes the knowledge gathered so far.
Schmitz
Hans-Peter
HP
Biozentrum Basel, Institut für Angewandte Mikrobiologie, Bio-Pharmazentrum University of Basel, Klingelbergstrasse 50-70, 4056, Basel, Switzerland.
Heinisch
Jürgen J
JJ
D000595:Amino Acid Sequence; D003545:Cysteine / Q000737:chemistry; D015971:Gene Expression Regulation, Enzymologic; D015966:Gene Expression Regulation, Fungal; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D008969:Molecular Sequence Data; D009154:Mutation; D010766:Phosphorylation; D011493:Protein Kinase C / Q000737:chemistry* / Q000235:genetics*; D017434:Protein Structure, Tertiary; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D013045:Species Specificity; D015003:Yeasts / Q000378:metabolism
D011493:Protein Kinase C; D003545:Cysteine