Geometry-based finite-element modeling of the electrical contact between a cultured neuron and a microelectrode.
The electrical contact between a substrate embedded microelectrode and a cultured neuron depends on the geometry of the neuron-electrode interface. Interpretation and improvement of these contacts requires proper modeling of all coupling mechanisms. In literature, it is common practice to model the neuron-electrode contact using lumped circuits in which large simplifications are made in the representation of the interface geometry. In this paper, the finite-element method is used to model the neuron-electrode interface, which permits numerical solutions for a variety of interface geometries. The simulation results offer detailed spatial and temporal information about the combined electrical behavior of extracellular volume, electrode-electrolyte interface and neuronal membrane.
Institute for Biomedical Technology, Signals & Systems Group, Faculty of Electrical Engineering, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands. J.R.Buitenweg@el.utwente.nl
Jan Reinoud
JR
Buitenweg
Wim L C
WL
Rutten
Enrico
E
Marani
D002462:Cell Membrane / Q000502:physiology; D048429:Cell Size / Q000502:physiology; D002478:Cells, Cultured; D003198:Computer Simulation; D004553:Electric Conductivity; D020342:Finite Element Analysis; D008564:Membrane Potentials / Q000502:physiology; D008839:Microelectrodes; D008959:Models, Neurological; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D012680:Sensitivity and Specificity