Investigating the effects of excipients on the powder flow characteristics of theophylline anhydrous powder formulations.
Pharmaceutical excipients may have a great effect on properties affecting tablet production. To determine if formulations containing theophylline anhydrous would have properties allowing them to be easily tableted, functional parameters affecting powder flow were evaluated. The Carr Flowability Indices were used for this evaluation. Formulations to be studied include theophylline anhydrous as the active ingredient, hydrous lactose and dicalcium phosphate dihydrate as diluents, polyvinylpyrrolidone as a binder, and fumed silica as a flow promoter. The effect of each component on powder flow is discussed.
Department of Industrial and Physical Pharmacy, Purdue University School of Pharmacy, West Lafayette, Indiana, USA. knagel@midwestern.edu
Karen M
KM
Nagel
Garnet E
GE
Peck
D002130:Calcium Phosphates / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D005079:Excipients / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry; D010316:Particle Size; D010592:Pharmaceutic Aids / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D011208:Powders; D012212:Rheology; D012822:Silicon Dioxide / Q000737:chemistry; D013607:Tablets; D013806:Theophylline / Q000737:chemistry*
D002130:Calcium Phosphates; D005079:Excipients; D010592:Pharmaceutic Aids; D011208:Powders; D013607:Tablets; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; D012822:Silicon Dioxide; C020243:calcium phosphate; D013806:Theophylline; D011205:Povidone; D007785:Lactose; C485829:calcium phosphate, dibasic, anhydrous