[Interaction of the diabetes insipidus locus alleles with the renal 120 kDa protein-encoding gene in rat development].
Age-dependant dynamics of the kidney inner medullary 120-kDa protein content in vasopressin-deficient Brattleboro rats with di/di mutant genotype was studied in comparison with WAG rats with genotype and normal vasopressin expression. Age-dependant dynamics of vasopressin content in neurohypophysis of WAG rats was also examined. It was shown that 10-day-old WAG rats were unable to elevate the synthesis of the 120 kDa protein in respond to long-term dehydration, while this tendency was clearly observed in the 15-day-old rats and later in the development. In WAG rats the onset of this specific feature was time correlated with the development of the respond to hydration by the elevation of vasopressin synthesis and release from neurohypophysis into blood. In the di/di rats dehydration had no effect on the kidney 120-kDa protein synthesis in all ages examined. These results point to the interaction between the di alleles and the 120-kDa protein-encoding gene in the course of development.
Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090 Russia. khegai@bionet.nsc.ru
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D000367:Age Factors; D000483:Alleles; D000818:Animals; D000831:Animals, Newborn; D003919:Diabetes Insipidus / Q000235:genetics*; D004326:Drinking; D018507:Gene Expression Regulation, Developmental; D007668:Kidney / Q000502:physiology*; D008970:Molecular Weight; D009154:Mutation; D010904:Pituitary Gland, Posterior / Q000502:physiology; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D011910:Rats, Brattleboro; D011919:Rats, Inbred Strains; D014667:Vasopressins / Q000235:genetics* / Q000378:metabolism
D011506:Proteins; D014667:Vasopressins