Powdered green tea has antilipogenic effect on Zucker rats fed a high-fat diet.
The effect of powdered green tea on the lipid metabolism was studied in male Zucker rats fed a 50% sucrose diet containing 15% butter. The oral treatment of 130 mg powdered green tea per day depressed body weight increase and various adipose tissue weights but food intake was unaffected. The treatment also slightly increased the plasma triglycerides. These effects were likely mediated by the inhibition of lipogenesis in the adipose tissues. The experimental group had a higher concentration of liver total lipid, triglycerides and plasma protein, and lower liver weights than the controls. This may be due to lipid deposition in the liver because of the reduction in adipose tissue weights. It was found that powdered green tea lowered the plasma total cholesterol but liver total cholesterol was unaffected. The results indicate that the hypocholesterolemic activity of powdered green tea might be due to the inhibition of the synthesis of cholesterol in the liver.
Hasegawa
Noboru
N
Department of Food and Nutrition, Nagoya Bunri College, Nagoya, Japan. hsgwn@nagoya-bunri.ac.jp
Yamda
Norihiro
N
Mori
Midori
M
D000273:Adipose Tissue / Q000187:drug effects* / Q000254:growth & development; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001628:Beverages; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000096:biosynthesis / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D008099:Liver / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011924:Rats, Zucker
D000924:Anticholesteremic Agents; D004041:Dietary Fats; D010936:Plant Extracts; D002784:Cholesterol