Kinetics of the action of three selenides on Staphylococcus aureus growth as studied by microcalorimetry.
The effect of three kinds of selenide on Staphylococcus aureus growth was studied by means of microcalorimetry. Differences in their capacities to inhibit the metabolism of this bacterium were observed. The rate constant k (in the log phase) in the presence of the compounds decreased with increasing concentrations of the compounds. The relationship of k and c is nearly linear for the selenium compounds. Judged from the rate constant, k, and the half-inhibitory concentration IC50, the experimental results reveal that the sequence of antibiotic activity of the three tested selenides compounds is (2-hydroxy benzyl imino)ethyl n-hexyl selenide> n-butyl(2- hydroxy benzyl imino)ethyl selenide > bis[(2,4-dihydroxy benzyl imino)ethyl] selenide.
Department of Chemistry, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, People's Republic of China.
Huigang
H
Liang
Jun
J
Wu
Yi
Y
Liu
Liping
L
Yang
Liming
L
Hu
Songsheng
S
Qu
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002151:Calorimetry; D007700:Kinetics; D016566:Organoselenium Compounds / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D016566:Organoselenium Compounds