[Antimicrobial activity of Laetiporus sulphureus strains grown in submerged culture].
Cultural conditions for growth and fruit body formation were elaborated to four strains of Laetiporus sulphureus isolated from nature. All strains demonstrated antimicrobial activity against a wide spectrum of gram-positive and gram-negative bacteria during agar and submerged cultivation including methicillin-resistant strain of Staphylococcus aureus (MRSA) and glycopeptide-resistant strain of Leuconostoc mesenteroides. Antifungal activity was not found. The level of antimicrobial activity during submerged cultivation reached maximum after seven days of growth on specific medium with soybean meal and corn liquid; the next four weeks its increasing was not so manifested. Antimicrobial activity correlated with orange pigment secretion and cultural liquid acidification to pH 2.0-2.8 that indicates on acid nature of synthesized products.
G. F. Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow.
E Iu
EIu
Ershova
O V
OV
Tikhonova
L M
LM
Lur'e
O V
OV
Efremenkova
O V
OV
Kamzolkina
Iu V
IuV
Dudnik
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D001487:Basidiomycota / Q000254:growth & development / Q000378:metabolism*; D003470:Culture Media; D024881:Drug Resistance, Bacterial; D006020:Glycopeptides; D006863:Hydrogen-Ion Concentration; D007934:Leuconostoc / Q000187:drug effects; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D013025:Glycine max; D013211:Staphylococcus aureus / Q000187:drug effects; D013997:Time Factors; D003313:Zea mays
D000900:Anti-Bacterial Agents; D003470:Culture Media; D006020:Glycopeptides; D010406:Penicillins; D008712:Methicillin