HPLC assay in plasma and preliminary pharmacokinetic study of a quinazolinone derivative with spasmolytic effect.
An analytical method for analysis of 3-(o-bromo)-phenyl-2-(2',3'-dihydroxypropylthio)-4(3H)-quinazolinone from rat plasma using HPLC with reversed phase C18 and liquid-liquid extraction was developed. This method was used for a pharmacokinetic study in rat.
Faculty of Pharmacy, Charles University, Prague, Hradec Králové, Czech Republic.
P
P
Kastner
J
J
Klimes
M
M
Láznícek
Th
T
Jira
D000818:Animals; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D020374:Chromatography, Micellar Electrokinetic Capillary; D019075:Electrophoresis, Capillary; D007202:Indicators and Reagents; D008297:Male; D009862:Online Systems; D010276:Parasympatholytics / Q000097:blood / Q000493:pharmacokinetics*; D011799:Quinazolines / Q000097:blood / Q000145:classification / Q000493:pharmacokinetics*; D052999:Quinazolinones; D051381:Rats; D017208:Rats, Wistar; D012015:Reference Standards; D015203:Reproducibility of Results; D013438:Sulfhydryl Compounds
C475105:3-(o-bromo)-phenyl-2-(2',3'-dihydroxypropylthio)-4(3H)-quinazolinone; D007202:Indicators and Reagents; D010276:Parasympatholytics; D011799:Quinazolines; D052999:Quinazolinones; D013438:Sulfhydryl Compounds