[Expression of C-myc and N-myc protein in adulthood and childhood medulloblastomas and prognostic analysis].
OBJECTIVE
To detect the expression of C-myc and N-myc in medulloblastomas, the difference between adults and children, and the relation between expression and prognosis.


METHODS
ABC immunostaining was used to detect C-myc and N-myc protein expression in 21 cases of adulthood medulloblastomas and 14 childhood cases. Follow-up materials were obtained to perform survival curve analysis.


RESULTS
Of these 35 cases, 5 (4 children, 1 adult) showed C-myc positive expression. No N-myc expression was found. There was no relationship between expression and survival.


CONCLUSIONS
C-myc may play a role in the tumorgenesis of medulloblastoma, especially in children, but it is of no prognostic significance. N-myc antigen may be lost during the fixation of specimens.
Department of Neurosurgery, First Affiliated Hospital, WCUMS, Chengdu 610041, China.
Y
Y
Liu
B
B
Mao
N
N
Hokeung
Y
Y
Chen
L
L
Gao
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002528:Cerebellar Neoplasms / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D008527:Medulloblastoma / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis*
D016271:Proto-Oncogene Proteins c-myc