Primary hyperhidrosis--evidence for autosomal dominant inheritance.
Primary hyperhidrosis is a neurogenic disorder of unknown cause characterized by excessive sweating in the palmar surface of the hands, armpits, groin and feet. In the course of a therapeutic trial for primary hyperhidrosis, 62 % of patients reported a positive family history. Examination of these pedigrees demonstrated a sibling recurrence risk of lambdas = 29-48 and an offspring recurrence risk of lambdao = 41-68 indicating that hyperhidrosis can be an inherited condition. The pattern of inheritance suggests an autosomal dominant mode of transmission with incomplete disease penetrance.
Dept. of Neurology, Mount Sinai School of Medicine, New York, USA.
Horacio
H
Kaufmann
Daniela
D
Saadia
Charlene
C
Polin
Stephen
S
Hague
Amanda
A
Singleton
Andrew
A
Singleton
D005260:Female; D005799:Genes, Dominant; D006225:Hand; D006801:Humans; D006945:Hyperhidrosis / Q000235:genetics*; D008297:Male; D010375:Pedigree