Topical nitrogen mustard ointment with occlusion for Langerhans' cell histiocytosis of the scalp.
BACKGROUND
Topical nitrogen mustard solution has been used as an effective alternative to corticosteroids for the treatment of cutaneous eruptions of Langerhans' cell histiocytosis (LCH). When used as an ointment under occlusion, nitrogen mustard may still be effective and possess less risk of unwanted side effects.


METHODS
A patient with scalp LCH was treated topically with nitrogen mustard ointment 0.01% under occlusion.


RESULTS
The lesions cleared in 3 weeks without irritation.


CONCLUSIONS
Topical nitrogen mustard ointment 0.01% under occlusion is a well-tolerated, non-irritating treatment for scalp LCH.
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
J R
JR
Treat
K R
KR
Suchin
W D
WD
James
D000279:Administration, Cutaneous; D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use*; D006646:Histiocytosis, Langerhans-Cell / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage / Q000627:therapeutic use*; D009824:Ointments; D012536:Scalp Dermatoses / Q000188:drug therapy*
D018906:Antineoplastic Agents, Alkylating; D009824:Ointments; D008466:Mechlorethamine