Post-exercise increase of lipid oxidation after a moderate exercise bout in untrained healthy obese men.
The aim of the study was to examine whether a moderate exercise increases the utilization of fatty acids during the recovery period in obese men. Six healthy obese participated in a randomized crossover investigation, one with exercise and one without exercise. At 8 a. m., the subjects had a standardized breakfast and they rested in a sitting position for 3 hours. The subjects were maintained in the sitting position for 4 additional hours in one session. In a second session, they exercised for 60 min at 50 % of their VO(2) max and then returned to the sitting position for 3 hours. Respiratory exchange ratio (RER) values were calculated by indirect calorimetry. During the resting session, plasma non-esterified fatty acids (NEFA) and glycerol concentrations rose progressively, whereas RER progressively decreased. During the exercise, plasma catecholamines, NEFA, glycerol, growth hormone and cortisol levels and RER increased while insulin decreased. During the recovery, plasma NEFA increased and glycerol decreased. During the first hour of recovery, RER values were lower and fatty acid utilization higher than during the same period of the resting session. The study shows that exercise induces modifications in hormonal factors promoting lipid mobilization and suggests that exercise provide substantial amounts of NEFA for muscle oxidation during recovery from an exercise bout in obese subjects.
Marion-Latard
F
F
Institut national de la santé et de la recherche médicale (INSERM Unit 586): Department of the Adaptation to the Exercise and Laboratory of Medical and Clinical Pharmacology, Faculty of Medicine, Toulouse, France.
Crampes
F
F
Zakaroff-Girard
A
A
De Glisezinski
I
I
Harant
I
I
Stich
V
V
Thalamas
C
C
Rivière
D
D
Lafontan
M
M
Berlan
M
M
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D018592:Cross-Over Studies; D004837:Epinephrine / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005990:Glycerol / Q000097:blood*; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D015227:Lipid Peroxidation; D008297:Male; D009638:Norepinephrine / Q000097:blood; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology; D010101:Oxygen Consumption / Q000502:physiology*; D015656:Respiratory Mechanics; D012146:Rest; D013997:Time Factors
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D019382:Human Growth Hormone; D005990:Glycerol; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine