Strangulated ventral hernia model in rats.
This study was performed to describe a new model of strangulation obstruction mimicking the situations relevant to abdominal hernias. The strangulation obstruction was induced either by intra-abdominal ligation of an ileal segment 2 cm in length (n = 20) or by a pursestring suture around a fascial defect with a strangulated intestinal loop placed subcutaneously (n = 20). Ten animals served as sham operated controls (n = 10). All animals were euthanized at 12 h postoperatively; strangulated ileum segments were collected for histopathological examination. Microscopic injury scores were similar in both strangulation groups, which were significantly different from the control group (p <.001). The model described here seems to be appropriate for use in further experimental studies concerning strangulation obstruction injury and its consequences, with the added advantage of visualization of the strangulated intestinal loop beneath the skin.
Demirkiran
Ahmet Ender
AE
Department of General Surgery, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey. aedemirkiran@yahoo.com
Ozgün
Hedef
H
Balkaya
Muharrem
M
Cevikel
Hakan
H
Culhaci
Nil
N
Gürel
Mehmet
M
D000818:Animals; D004195:Disease Models, Animal; D006555:Hernia, Ventral / Q000150:complications / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007415:Intestinal Obstruction / Q000209:etiology / Q000473:pathology; D008297:Male; D009336:Necrosis; D051381:Rats; D017207:Rats, Sprague-Dawley