Cerebellar central liponeurocytoma.
Cerebellar liponeurocytoma is a rare, benign neuroepithelial tumor that occurs exclusively in the cerebellum of adults. Its salient histological features include advanced neuronal/neurocytic differentiation, focal vacuolated cells resembling mature adipose cells, low mitotic activity, and lack of endothelial proliferation and/or necrosis. The morphological appearance of this neoplasm can be confused with that of oligodendroglioma, neurocytoma, ependymoma, medulloblastoma, hemangioblastoma, metastatic renal cell carcinoma, and other clear cell carcinomas. Its full biological potential and histological features, however, have not been fully exploited due to the rarity of this tumor. The authors describe a case with clinical, imaging, histological, immunohistochemical, and ultrastructural features.
Department of Pathology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA.
Kar-Ming
KM
Fung
Wenjing
W
Fang
Ralph E
RE
Norton
Norman
N
Torres
Allen
A
Chu
Lauren A
LA
Langford
D014408:Biomarkers, Tumor / Q000032:analysis*; D002528:Cerebellar Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008067:Lipoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D008875:Middle Aged; D018306:Neurocytoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
D014408:Biomarkers, Tumor