Pharmacokinetics of BNP7787 and its metabolite mesna in plasma and ascites: a case report.
OBJECTIVE
BNP7787 (2',2'-dithio-bis-ethane sulfonate sodium) is a novel protector against cisplatin-induced toxicities. The pharmacokinetics of BNP7787 and its metabolite mesna were investigated in plasma and ascites of a cancer patient. We also evaluated potential pharmacokinetic interactions between BNP7787 and cisplatin.


METHODS
BNP7787 and mesna were measured as mesna in deproteinized plasma and ascites using high-performance liquid chromatography with an electrochemical detector provided with a wall-jet gold electrode.


RESULTS
After the i.v. administration of 41 g/m(2) BNP7787, BNP7787 and mesna had a half-life of 1.5 and 3.4 h, respectively. The AUC( infinity ) of mesna was approximately 8% of the AUC( infinity ) of BNP7787. Coadministration of cisplatin did not appear to influence the plasma concentration-time curves of BNP7787 and mesna. In ascites, approximately 0.02% of the BNP7787 dose was present as mesna, whereas approximately 4% of the dose was present as BNP7787 at the time of the maximum concentration.


CONCLUSIONS
It can be concluded that the presence of ascites did not have a major impact on the pharmacokinetics of BNP7787 and coadministration of cisplatin did not influence the pharmacokinetics of BNP7787 and mesna.
Verschraagen
Miranda
M
Department of Medical Oncology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands. M.Verschraagen@vumc.nl
Boven
Epie
E
Zegers
Ivon
I
Hausheer
Frederick H
FH
Van der Vijgh
Wim J F
WJ
D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology; D019540:Area Under Curve; D001201:Ascites / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002945:Cisplatin / Q000494:pharmacology; D004563:Electrochemistry; D006207:Half-Life; D006801:Humans; D008297:Male; D015080:Mesna / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*
D000970:Antineoplastic Agents; C027032:2,2'-dithiodiethanesulfonic acid; D015080:Mesna; D002945:Cisplatin