Lessons for human diabetes from experimental mouse models.
A precise knowledge of the defects underlying type 1 and type 2 diabetes is essential for designing appropriate therapeutic strategies. Because experiments in humans are limited, naturally occurring, and especially genetically engineered rodent models, have revolutionized research in diabetes. We review some of the models created recently and discuss their impact on human diabetes.
Joslin Diabetes Center, One Joslin Place, Room 602, Boston, MA 02215, USA. Rohit.Kulkarni@joslin.harvard.edu
Rohit N
RN
Kulkarni
Ariel
A
Zisman
D000818:Animals; D016207:Cytokines / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology* / Q000628:therapy; D004195:Disease Models, Animal; D015316:Genetic Therapy; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance; D007328:Insulin / Q000378:metabolism; D007515:Islets of Langerhans / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic
D016207:Cytokines; D000949:Histocompatibility Antigens Class II; D007328:Insulin