Insulin secretion: fatty acid signalling via serpentine receptors.
Insulin secretion is thought principally to be regulated by blood glucose concentration. Three recent studies emphasise the additional importance of fatty acids as regulators of insulin secretion, and demonstrate the involvement of a novel G protein-coupled receptor.
Henry Wellcome Laboratories for Integrated Cell Signalling and Department of Biochemistry, School of Medical Sciences, University of Bristol, UK. g.a.rutter@bris.ac.uk
Guy A
GA
Rutter
D000818:Animals; D005227:Fatty Acids / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism / Q000502:physiology*; D051964:Receptors, Mating Factor; D018000:Receptors, Peptide / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors
D005227:Fatty Acids; D007328:Insulin; D043562:Receptors, G-Protein-Coupled; D051964:Receptors, Mating Factor; D018000:Receptors, Peptide; D014157:Transcription Factors