Comparison of nicotine patch alone versus nicotine nasal spray alone versus a combination for treating smokers: a minimal intervention, randomized multicenter trial in a nonspecialized setting.
This multicenter, randomized, open-label clinical trial was conducted to determine whether the combined use of nicotine patch therapy and a nicotine nasal spray would improve smoking abstinence rates compared to either treatment alone, without behavioral counseling. Data were collected at 15 regional cancer control oncology centers within the North Central Cancer Treatment Group. Of the 1384 smokers randomized to the study, 20% were abstinent from smoking at 6 weeks and 8% were abstinent at 6 months. At 6 weeks, the 7-day point prevalence smoking abstinence rate for the patch alone (21.1%) was superior to the spray (13.6%) but was significantly lower than the rate for combination therapy (27.1%). At 6 months, the 7-day point prevalence abstinence rates were not significantly different among the three groups. Combination nicotine nasal spray and nicotine patches were delivered safely in a nonspecialized outpatient clinical setting and enhanced short-term smoking abstinence rates, but these rates were not sustained at 6 months.
Croghan
Gary A
GA
Mayo Clinic and Mayo Foundation Rochester MN 55905, USA. crogham.gary@mayo.edu
Sloan
Jeff A
JA
Croghan
Ivana T
IT
Novotny
Paul
P
Hurt
Richard D
RD
DeKrey
Wanda L
WL
Mailliard
James A
JA
Ebbert
Larry P
LP
Swan
Debra K
DK
Walsh
Daniel J
DJ
Wiesenfeld
Martin
M
Levitt
Ralph
R
Stella
Philip
P
Johnson
Patricia A
PA
Tschetter
Loren K
LK
Loprinzi
Charles
C
D000279:Administration, Cutaneous; D000281:Administration, Intranasal; D000328:Adult; D000553:Ambulatory Care; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009538:Nicotine / Q000008:administration & dosage*; D018722:Nicotinic Agonists / Q000008:administration & dosage*; D015995:Prevalence; D012907:Smoking / Q000453:epidemiology / Q000628:therapy*; D016540:Smoking Cessation / Q000379:methods* / Q000706:statistics & numerical data; D013997:Time Factors
D018722:Nicotinic Agonists; D009538:Nicotine