An automated approach to quantitative air trapping measurements in mild cystic fibrosis.
OBJECTIVE
To automatically derive the degree of air trapping in mild cystic fibrosis (CF) disease from high-resolution CT (HRCT) data, and to evaluate the discriminating power of the measurement.


METHODS
The data consist of six pairs of anatomically matched tomographic slices, obtained during breath-holding in triggered HRCT acquisitions. The pairs consist of an inspiratory slice, at > or = 95% of slow vital capacity, and an expiratory slice at near residual volume (nRV). The subjects are 25 patients with mild CF and 10 age-matched, normal control subjects.


METHODS
Lung segmentation is automatic. The limits defining air trapping in the expiratory slices are determined by the distribution of densities in the expanded lung. They are modulated by density changes between expiration and inspiration. Air trapping defects consist of contiguous low-density voxels. The difference between patients and control subjects was evaluated in comparison to pulmonary function test (PFT) results and lung density distribution descriptors (global density descriptors).


RESULTS
In mild CF, air trapping does not correlate with global PFT results, except for the ratio of residual volume (RV) to total lung capacity (TLC); however, the size of air trapping defects was the best discriminator between patients and control subjects (p < 0.005). Of PFT results, only RV/TLC reached significance at p < 0.05. The global density descriptors reached near significance in the nRV images only.


CONCLUSIONS
Air trapping defined as defect size and measured in an objective automated manner is a powerful discriminator for mild CF.
Division of Nuclear Medicine/Radiology, Stanford University, CA 94305, USA. mlgoris@stanford.edu
Michael L
ML
Goris
Hongyun J
HJ
Zhu
Francis
F
Blankenberg
Frandics
F
Chan
Terry E
TE
Robinson
D000293:Adolescent; D002648:Child; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008450:Maximal Midexpiratory Flow Rate; D012115:Residual Volume; D013147:Spirometry; D014057:Tomography, X-Ray Computed; D014797:Vital Capacity