Intracranial venous sinus thrombosis complicating AIDS-associated nephropathy.
An alert and oriented 27-year-old African American woman with AIDS presented with a 10-day history of fever, cough productive of yellow sputum, nausea, and vomiting and a 1-day history of excruciating headache and photophobia. Her condition rapidly deteriorated into a coma with decorticate and then decerebrate posture, and she died 3 weeks later. There was evidence of extensive intracranial venous sinus thrombosis (ICVST), renal vein thrombosis (RVT), and multiple cerebral hemorrhagic infarcts due to a hypercoagulable state complicating AIDS-associated nephrotic syndrome. This is the first reported case of fatal ICVST and RVT with extensive cerebral hemorrhagic infarcts complicating nephrotic syndrome in a patient with AIDS.
Division of Infectious Diseases, Touro University College of Osteopathic Medicine, Vallejo, California, USA.
Khosrow
K
Afsari
Jeffrey
J
Frank
Yulia
Y
Vaksman
Thanhan V
TV
Nguyen
D016263:AIDS-Associated Nephropathy / Q000150:complications*; D000328:Adult; D002550:Cerebral Veins; D005260:Female; D006801:Humans; D009404:Nephrotic Syndrome / Q000150:complications*; D012082:Renal Veins; D020246:Venous Thrombosis / Q000188:drug therapy / Q000209:etiology*