A link between Helicobacter pylori and/or Chlamydia spp. infections and atherosclerosis.
Antibodies to Helicobacter pylori, Chlamydia spp. and Mycobacterium bovis were determined in patients with coronary heart disease, H. pylori-related dyspepsia, and tuberculosis, and healthy controls. Enzyme-linked immunosorbent assay was conducted with a glycine extract and CagA protein of H. pylori, chlamydial lipopolysaccharide and mycobacterial heat shock protein Hsp65. The prevalence of anti-glycine extract IgG in coronary heart disease patients was higher than in the tuberculosis group and controls, and the same as in dyspeptic patients. Anti-chlamydial IgG were more prevalent in the coronary heart disease group than in healthy subjects. There was no difference in the prevalence of anti-CagA IgG in the coronary heart disease group and controls or anti-Hsp65 IgG in the patients with coronary heart disease, dyspepsia, tuberculosis, and controls. Anti-glycine extract IgA (like anti-glycine extract IgG) were more prevalent in the coronary heart disease group than in the healthy group. The highest anti-glycine extract IgG/IgA and anti-chlamydial IgG titers were more frequent in coronary heart disease patients as compared with controls. Infections with H. pylori and Chlamydia spp. and enhanced production of antibodies to these pathogens may predispose to human atherosclerosis.
Chmiela
Magdalena
M
Department of Immunology and Infectious Biology, Institute for Microbiology and Immunology, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland. chmiela@biol.uni.lodz.pl
Kowalewicz-Kulbat
Magdalena
M
Miszczak
Aneta
A
Wisniewska
Monika
M
Rechcinski
Tomasz
T
Kolodziej
Katarzyna
K
Kasprzak
Jaroslaw
J
Wadstrom
Torkel
T
Rudnicka
Wieslawa
W
D000328:Adult; D000368:Aged; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001161:Arteriosclerosis / Q000209:etiology*; D001426:Bacterial Proteins / Q000276:immunology; D002417:Cattle; D018834:Chaperonin 60 / Q000276:immunology; D018833:Chaperonins / Q000276:immunology; D002689:Chlamydia / Q000276:immunology*; D023521:Chlamydophila Infections / Q000150:complications*; D003327:Coronary Disease / Q000276:immunology; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008070:Lipopolysaccharides / Q000276:immunology; D008875:Middle Aged; D009163:Mycobacterium bovis / Q000276:immunology; D014376:Tuberculosis / Q000150:complications
D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D018834:Chaperonin 60; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D008070:Lipopolysaccharides; C074119:heat-shock protein 65, Mycobacterium; D018833:Chaperonins