Influence of dorzolamide on corneal endothelium.
OBJECTIVE
To evaluate the influence of topical 1% dorzolamide treatment for 3 months on the endothelial morphology and the thickness of the cornea.


METHODS
The corneal endothelium was investigated in 21 glaucoma patients (29 eyes) who received topical 1% dorzolamide treatment for 3 months. Intraocular pressure, corneal endothelium, and central corneal thickness (CCT) were measured before and 3 months after topical dorzolamide treatment. The relation between the endothelial cell density loss or the CCT increase, and factors such as the history of previous intraocular surgery, the presence of type II diabetes mellitus, type of glaucoma, intraocular pressure before treatment (above or below 20 mm Hg), or the kinds of eye drops used before dorzolamide treatment were evaluated.


RESULTS
The endothelial cell density, coefficient of variation of cell area, and percentage of hexagonal cells did not change significantly. The CCT after treatment (537 +/- 34 microm) was significantly increased over that before treatment (530 +/- 33 microm). There was no significant relation of endothelial cell loss or CCT increase to any of the above factors.


CONCLUSIONS
Topical 1% dorzolamide treatment increases CCT and does not affect corneal endothelial morphology.
Department of Ophthalmology, Nadogaya Hospital, Chiba, Japan.
Kenji
K
Inoue
Kazuko
K
Okugawa
Tetsuro
T
Oshika
Shiro
S
Amano
D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage*; D002452:Cell Count; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004728:Endothelium, Corneal / Q000166:cytology / Q000187:drug effects*; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000188:drug therapy*; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D013449:Sulfonamides / Q000008:administration & dosage*; D013876:Thiophenes / Q000008:administration & dosage*
D002257:Carbonic Anhydrase Inhibitors; D009883:Ophthalmic Solutions; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide