For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection.
The surveillance of the structural fidelity of the proteome is of utmost importance to all cells. The endoplasmic reticulum (ER) is the organelle responsible for proper folding and delivery of proteins to the secretory pathway. It contains a sophisticated protein proofreading and elimination mechanism. Failure of this machinery leads to disease and, finally, to cell death. Elimination of misfolded proteins requires retrograde transport across the ER membrane and depends on the central cytoplasmic proteolytic machinery involved in cellular regulation: the ubiquitin-proteasome system. The basics of this process as well as recent advances in the field are reviewed.
Kostova
Zlatka
Z
Institut für Biochemie, Universität Stuttgart, Pfaffenwaldring 55, Germany.
Wolf
Dieter H
DH
D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism; D008954:Models, Biological; D010447:Peptide Hydrolases / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D017510:Protein Folding; D021381:Protein Transport / Q000502:physiology; D025801:Ubiquitin / Q000378:metabolism*
D005656:Fungal Proteins; D025801:Ubiquitin; D010447:Peptide Hydrolases; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease