Cobalt-catalyzed one-pot three-component coupling route to beta-acetamido carbonyl compounds: a general synthetic protocol for gamma-lactams.
An efficient improved procedure for the synthesis of beta-acetamido carbonyl compounds is developed by a cobalt(II) chloride-catalyzed three-component coupling protocol. The procedure is also amenable to the synthesis of gamma-lactams by a three-component coupling reaction with use of 2-carbomethoxybenzaldehyde. The beta-acetamido carbonyl compounds derived from 2-carbomethoxybenzaldehyde are useful intermediates as they can be transformed to the corresponding gamma-lactams on treatment with base.
Dr. Reddy's Research Foundation, Bollaram Road, Miyapur, Hyderabad 500 050, India.
I Nageshwar
IN
Rao
E N
EN
Prabhakaran
Saibal Kumar
SK
Das
Javed
J
Iqbal
D000081:Acetamides / Q000737:chemistry; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D003035:Cobalt / Q000737:chemistry*; D004151:Dipeptides / Q000138:chemical synthesis*; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D047090:beta-Lactams / Q000138:chemical synthesis*
D000081:Acetamides; D004151:Dipeptides; D007659:Ketones; D047090:beta-Lactams; D003035:Cobalt