Miller Fisher variant of Guillain-Barré syndrome associated with lactic acidosis and stavudine therapy.
We describe the first case of Miller Fisher syndrome (opthalmoplegia, ataxia, and areflexia) associated with lactic acidosis as an adverse effect of receipt of an antiretroviral regimen containing stavudine. We review this syndrome in the context of recent descriptions of neuromuscular toxicities attributed to nucleoside analogue reverse-transcriptase inhibitor-induced mitochondrial toxicity.
Department of Medicine, Bronx-Lebanon Hospital Center, Bronx, New York 10457, USA.
Sanjiv S
SS
Shah
Tomas
T
Rodriguez
Joseph P
JP
McGowan
D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000150:complications*; D000818:Animals; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D019846:Miller Fisher Syndrome / Q000150:complications*; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects*; D018119:Stavudine / Q000009:adverse effects*
D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors; D018119:Stavudine