[Study on the cytocompatibility of biodegradable poly(epsilon-caprolactone) microspheres in vitro].
Poly(epsilon-caprolactone) microspheres were fabricated with an average particle size of 5.08 +/- 0.23 microns. The effect of poly(epsilon-caprolactone) microspheres on apoptosis and cell cycle of fibroblast was studied with flow cytometry. The data obtained clearly indicated that poly(epsilon-caprolactone) microspheres purified in different ways showed different cytocompatibility. The well purified microspheres have good cytocompatibility.
Central Laboratory, First Military Medical University, Guangzhou 510515.
Qizhi
Q
Luo
Jianhai
J
Chen
Kaijin
K
Dai
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000494:pharmacology*; D001673:Biodegradation, Environmental; D066298:In Vitro Techniques; D008422:Materials Testing; D051379:Mice; D008863:Microspheres; D011091:Polyesters / Q000138:chemical synthesis / Q000494:pharmacology*
D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone