Serum IGF-I and IGFBP-3 in healthy pregnancies and patients with preeclampsia.
METHODS
We studied serum levels of IGF-I and IGFBP-3 in 68 pregnant women; 28 mild preeclampsia, 13 severe preeclampsia, and 27 healthy pregnant control subjects.


RESULTS
When compared with the healthy pregnant group preeclampsia groups had markedly decreased mean serum IGF-I levels. The difference was also significant between the mild and severe preeclampsia groups. Serum mean IGFBP-3 level was also lower in both preeclampsia groups than in healthy pregnancy group, but the difference between the preeclampsia groups did not reach significance. For IGF-I/IGFBP-3 ratio, the mean levels were significantly lower in mild and severe preeclampsia groups than in healthy pregnancy group. Also the mean IGF-I/IGFBP-3 ratio was significantly lower in the severe preeclampsia group compared with the mild preeclampsia group.


CONCLUSIONS
IGF-1 and IGFBP-3 levels in patients with preeclampsia were compared with healthy pregnant control subjects. IGF-I and IGF-I/IGFBP-3 ratio may be useful for estimate the severity of preeclampsia.
Altinkaynak
Konca
K
Department of Biochemistry, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey.
Aksoy H
H ülya
Hü
Bakan
Ebubekir
E
Kumtepe
Yakup
Y
D035061:Control Groups; D005260:Female; D005865:Gestational Age; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000032:analysis* / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D011225:Pre-Eclampsia / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy
D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I