Peripheral nerve injury influences the disinhibition induced by focal ischaemia in the rat motor cortex.
Photothrombotic lesions were produced in the rat primary motor cortex, and the brain excitability was assessed in a paired-pulse stimulation protocol by transcranial recording, in parallel at 16 points of the frontal cortex, including the insulted and the surrounding areas. The cortical lesion reduced the inhibition in the extended frontal cortex, with a delay of a few minutes. Unilateral facial nerve transection, however, accelerated the widespread disinhibition. Although the mechanism is not clear in detail, both peripheral and central injury-induced disinhibition may have a significant impact on the recovery of the function.
Farkas
Tamás
T
Department of Comparative Physiology, University of Szeged, Közép fasor 52, H-6726, Szeged, Hungary.
Racekova
Eniko
E
Kis
Zsolt
Z
Horváth
Szatmár
S
Burda
Jozef
J
Galik
Jan
J
Toldi
József
J
D000818:Animals; D019771:Axotomy / Q000009:adverse effects; D002545:Brain Ischemia / Q000503:physiopathology*; D004594:Electrophysiology; D020220:Facial Nerve Injuries / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology*; D009433:Neural Inhibition; D051381:Rats; D017207:Rats, Sprague-Dawley