Hemsleyatine, a novel C19-diterpenoid alkaloid with 8-amino group from Aconitum hemsleyanum.
The new compound hemsleyatine (1) was isolated along with four known C(19)-diterpenoid alkaloids: indaconitine (4), yunaconitine (5), chasmanine (6), and talatisamine (7) from the roots of Aconitum hemsleyanum PRITZ. Structures were established by spectral analysis, including tow dimeusional (2D) NMR spectroscopy and a chemical method. Hemsleyatine (1) is the first C(19)-diterpenoid alkaloid bearing the 8-amino group. In addition, the assignments of some (13)C signals for pseudaconine (3) were revised by comparison with those of hemsleyatine (1).
Zhou
Xian-Li
XL
Department of Bioengineering, Southwest Jiaotong University, Chengdu, P.R. China.
Chen
Qiao-Hong
QH
Chen
Dong-Lin
DL
Wang
Feng-Peng
FP
D000107:Acetylation; D031841:Aconitum / Q000737:chemistry*; D002681:China; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D018517:Plant Roots / Q000737:chemistry
D004224:Diterpenes; D007202:Indicators and Reagents; C479944:hemsleyatine