Embolization with autologous fibroblast-attached platinum coils in canine carotid artery aneurysms: histopathological differences from plain coil embolization.
OBJECTIVE
This study was designed to evaluate the effect of autologous fibroblast-attached platinum coils on the promotion of intra-aneurysmal thrombus organization.


METHODS
Sidewall aneurysms were surgically created at common carotid arteries bilaterally in 5 dogs. Fibroblasts were obtained from the skins of the dogs and cultured and attached to unmodified platinum coils in a 5-day coculture. In each animal, one aneurysm was embolized with fibroblast-attached platinum coils (study group) and the other with plain platinum coils of the same size (control group).


RESULTS
All aneurysms were partially occluded; the mean occlusion rate was 67%. The histologic analyses performed 2 weeks after the embolization showed more advanced organization of intra-aneurysmal thrombus in the study group than in the control group (80% versus 53%, P = 0.02). Overgrowth of the organizing tissue and parent artery stenosis did not occur.


CONCLUSIONS
Our results suggest that autologous fibroblasts delivered with platinum coils could promote the organization of intra-aneurysmal thrombus. Although further research is needed, especially on the potential complications, endovascular treatment using autologous fibroblasts may be applied to aneurysm treatment.
Kwon
O-Ki
OK
Department of Neurosurgery, College of Medicine, Seoul National University, Seoul, Korea.
Han
Moon Hee
MH
Oh
Chang Wan
CW
Park
In Ae
IA
Choe
Gheeyoung
G
Lee
Kyoung Ho
KH
Chang
Kee-Hyun
KH
Han
DaeHee
D
D000783:Aneurysm / Q000628:therapy*; D000818:Animals; D002340:Carotid Artery Diseases / Q000628:therapy*; D002478:Cells, Cultured; D004285:Dogs; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D005347:Fibroblasts; D010984:Platinum; D018709:Statistics, Nonparametric
D010984:Platinum