Predominant maternal expression of the mouse Atp10c in hippocampus and olfactory bulb.
The human chromosome 15q11-q13 region is one of the most intriguing imprinted domains, and the abnormalities inherited are associated with neurological disorders including Prader-Willi syndrome (PWS), Angelman syndrome (AS) and autism. Recently we have identified a novel maternally expressed gene, ATP10C, that encodes a putative aminophospholipid translocase within this critical region, 200 kb distal to UBE3A in an imprinted domain on human chromosome 15. ATP10C, with UBE3A, displayed tissue-specific imprinting with predominant expression of the maternal allele in the brain. In this study, we demonstrated that the mouse homologue, Atp10c/pfatp, showed tissue-specific maternal expression in the hippocampus and olfactory bulb, which overlapped the region of imprinted Ube3a expression. These data suggest that the imprinted transcript of Atp10c in the specific region of CNS may be associated with neurological disorders including AS and autism.
Division of Molecular and Cell Genetics, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, 86 Nishimachi, Yonago 683-8503, Japan.
Akiko
A
Kashiwagi
Makiko
M
Meguro
Hidetoshi
H
Hoshiya
Masayuki
M
Haruta
Fumitoshi
F
Ishino
Toshiyuki
T
Shibahara
Mitsuo
M
Oshimura
D000251:Adenosine Triphosphatases / Q000235:genetics*; D000818:Animals; D018899:CpG Islands / Q000235:genetics; D019175:DNA Methylation; D005260:Female; D020869:Gene Expression Profiling; D018392:Genomic Imprinting; D006624:Hippocampus / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000235:genetics*; D051379:Mice; D009830:Olfactory Bulb / Q000378:metabolism*; D009928:Organ Specificity; D012150:Polymorphism, Restriction Fragment Length; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D026901:Membrane Transport Proteins; D012333:RNA, Messenger; D000251:Adenosine Triphosphatases; C478764:ATP10a protein, mouse