Non-fatal acute liver injury possibly related to high-dose ciprofloxacin.
Fulminant hepatic failure is an uncommon but life-threatening adverse reaction to antibiotic therapy. Reported here is a case of severe liver injury associated with ciprofloxacin administered for treatment of a gram-negative infection in a 79-year-old female. The patient presented with metabolic acidosis 48 hours after the first ciprofloxacin intake. Symptoms resolved after cessation of ciprofloxacin therapy. This report highlights an uncommon side effect of a commonly used antimicrobial agent.
Goetz
M
M
Medical Clinic I, University of Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany. mgoetz@mail.uni-mainz.de
Galle
P R
PR
Schwarting
A
A
D000368:Aged; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000009:adverse effects*; D003422:Critical Care / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007362:Intensive Care Units; D008099:Liver / Q000187:drug effects* / Q000293:injuries; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000503:physiopathology; D008111:Liver Function Tests; D018570:Risk Assessment; D012720:Severity of Illness Index
D002939:Ciprofloxacin