Nuclear lipid signalling.
During the past twenty years, evidence has accumulated for the presence of phospholipids within the nuclei of eukaryotic cells. These phospholipids are distinct from those that are obviously present in the nuclear envelope. The best characterized of the intranuclear lipids are the inositol lipids that form the components of a phosphoinositide-phospholipase C cycle. However, exactly as has been discovered in the cytoplasm, this is just part of a complex picture that involves many other lipids and functions.
Department of Pharmacology, Tennis Court Road, Cambridge CB2 1QJ, UK. rfi20@cam.ac.uk
Robin F
RF
Irvine
D019870:1-Phosphatidylinositol 4-Kinase / Q000378:metabolism; D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D050356:Lipid Metabolism; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D015398:Signal Transduction; D010738:Type C Phospholipases / Q000378:metabolism*
D006133:Growth Substances; D007527:Isoenzymes; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; C060980:phosphatidylinositol 3,4-diphosphate; D019869:Phosphatidylinositol 3-Kinases; D019870:1-Phosphatidylinositol 4-Kinase; D010738:Type C Phospholipases