Predictive value of brain-specific proteins in serum for neurodevelopmental outcome after birth asphyxia.
Brain-specific proteins have been used to detect cerebral injury after birth asphyxia. Previous investigations suggest that serum protein S-100beta, brain-specific creatine kinase (CK-BB), and neuron-specific enolase (NSE) are capable of identifying patients with a risk of developing hypoxic-ischemic encephalopathy. Whether detection of elevated serum concentrations of these proteins reflects long-term neurodevelopmental impairment remains to be investigated. We examined serum protein S-100beta, NSE, and CK-BB at 2, 6, 12, and 24 h after birth in 29 asphyxiated infants and 20 control infants. Neurodevelopmental follow-up examinations were performed at 20 mo of age using the German revision of the Griffiths scales for developmental assessment. Elevated concentrations of serum protein S-100beta, NSE, and CK-BB within 24 h after asphyxia did not correlate with long-term neurodevelopmental delay. We conclude that serum protein S-100beta, NSE, and CK-BB, sampled on the first day of life, is of limited value in predicting severe brain damage after birth asphyxia.
Department of Neonatology, Charité Virchow University Hospital, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. nicole.nagdyman@charite.de
Nicole
N
Nagdyman
Ingrid
I
Grimmer
Tristess
T
Scholz
Christian
C
Muller
Michael
M
Obladen
D001238:Asphyxia Neonatorum / Q000097:blood* / Q000175:diagnosis*; D015415:Biomarkers; D003402:Creatine Kinase / Q000097:blood*; D052276:Creatine Kinase, BB Form; D002658:Developmental Disabilities / Q000097:blood / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D009414:Nerve Growth Factors; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011237:Predictive Value of Tests; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*
D015415:Biomarkers; D007527:Isoenzymes; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D003402:Creatine Kinase; D052276:Creatine Kinase, BB Form; D010751:Phosphopyruvate Hydratase