Long-term potentiation and the ageing brain.
Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.
Barnes
C A
CA
Departments of Psychology and Neurology, and ARL Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724, USA. carol@nsma.arizona.edu
D000375:Aging / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D004594:Electrophysiology; D006624:Hippocampus / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology*; D008568:Memory / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D013569:Synapses / Q000502:physiology