Improving the mouse model for studying the efficacy of voriconazole.
Outbred ICR mice were rendered neutropenic, infected intravenously with Fusarium solani and treated orally with voriconazole. When given alone, voriconazole was not protective up to 40 mg/kg/day. When grapefruit juice was administered before infection, mice were protected by voriconazole. The mechanism may be inhibition of gut mucosal cytochrome enzymes that rapidly degrade voriconazole in the mouse. These murine studies support expansion of voriconazole therapy in other highly resistant systemic mycoses.
Graybill
John R
JR
The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases (7881), 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. jrgraybill@aol.com
Najvar
Laura K
LK
Gonzalez
Gloria M
GM
Hernandez
Steve
S
Bocanegra
Rosie
R
D000818:Animals; D001628:Beverages; D032083:Citrus paradisi; D004195:Disease Models, Animal; D005670:Fusarium / Q000187:drug effects* / Q000254:growth & development; D007668:Kidney / Q000187:drug effects / Q000382:microbiology; D051379:Mice; D008813:Mice, Inbred ICR; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use*; D013154:Spleen / Q000187:drug effects / Q000382:microbiology; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use*; D065819:Voriconazole
D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole