A novel bicyclic ketolide derivative.
A novel bicyclic ketolide derivative, 10,11-didehydro-11-deoxy-3-O-descladinosyl-6-O-methyl-3-oxo-8,9-anhydroerythromycin 9,12-hemiacetal(6) was obtained from 3-O-descladinosyl-6-O-methylerythromycin 2'-acetate. The structure and stereochemistry of this novel compound were elucidated and established by NMR and X-ray crystallography.
Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, Jiangsu 210009, PR China.
Ying
Y
Zhao
Qidong
Q
You
Wenbin
W
Shen
D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D017291:Clarithromycin / Q000031:analogs & derivatives; D018360:Crystallography, X-Ray; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D019086:Bridged Bicyclo Compounds, Heterocyclic; D018942:Macrolides; D017291:Clarithromycin