Bioavailability of a pediatric amlodipine suspension.
Currently, a suspension of crushed tablets of amlodidpine is widely used in children with hypertension without knowledge of its bioavailability. A comparative bioavailability study of a tablet and suspension formulation of amlodipine was completed in 20 healthy adult volunteers. Bioequivalence of the suspension was not different from the tablets. These results support the use of the suspension in children who cannot take the tablet.
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada.
Dorothy A
DA
Lyszkiewicz
Zina
Z
Levichek
Eran
E
Kozer
Yaron
Y
Yagev
Myla
M
Moretti
Marjie
M
Hard
Gideon
G
Koren
D000328:Adult; D017311:Amlodipine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013535:Suspensions; D013607:Tablets
D002121:Calcium Channel Blockers; D013535:Suspensions; D013607:Tablets; D017311:Amlodipine