[Expression of co-receptor on different T lymphocytes subpopulations after effective HAART].
To measure CCR5 and CXCR4 chemokine receptor expression on CD4 and CD8 T cells in HIV-1 infection and to relate levels to the distribution of CD45RO memory and CD45RA-naive subsets after effective HAART.



Four-color cytofluorometry with appropriate conjugated monoclonal antibodies (mAbs) was performed to define CD45RA and CD45RO subsets of CD4 and CD8 T cells and measure the expression of CCR5, CXCR4 in blood from 43 received HAART patients and 5 non-treated HIV and 13 healthy controls.



The levels of CCR5 and CXCR4 on CD4 and CD8 T cells and their CD45RO/CD45RA subsets in HIV-1-infected patients had not any statistical significance than that on control subjects and effective HAART could adjust the expression on T cells.



CXCR4/CCR5 plays an important role in the progress of HIV-1 infection. The most favorable condition for treatment should be initiated before stage B.
Li
Dan
D
The Institute of Infectious Disease, The First Affiliated Hospital, College of Medical Sciences, Zhejiang Univesity, Hangzhou 310006, China.
Wu
Nan-ping
NP
Bader
Armin
A
Hoxtermann
Stefan
S
Brockmeyer
Norbert
N
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology; D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry*; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry*; D015497:HIV-1; D006801:Humans; D019713:Receptors, CCR5 / Q000097:blood / Q000187:drug effects*; D019718:Receptors, CXCR4 / Q000097:blood / Q000187:drug effects*
D019713:Receptors, CCR5; D019718:Receptors, CXCR4