New substituted 2-(pyrazol-1-yl)-dialkylacetanilides with potential local anesthetic and antiarrhythmic action. Part II.
Nine substituted 2-(pyrazol-1-yl)-dialkylacetanilides were synthesized by N-alkylation of pyrazole and its derivatives with several 2-iodoacetanilides. The new compounds exhibited local anesthetic and antiarrhythmic actions. They have been characterized by elemental chemical analysis, UV-Vis, IR, 1H NMR, 13C NMR, SM spectra and pharmacology research.
Iovu
Mircea
M
Center Research Synthesis and Organic Analysis, University of Medicine and Pharmaceutics 'Carol Davila', 6 Traian Vuia St., Bucharest, Romania. iovu@gg.unibuc.ro
Zalaru
Christina
C
Dumitrascu
Florea
F
Draghici
Constantin
C
Moraru
Mircea
M
Cristea
Elena
E
D000083:Acetanilides / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D000779:Anesthetics, Local / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D023382:Toxicity Tests, Acute
D000083:Acetanilides; D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D011720:Pyrazoles