[Destruction of amyloid beta-protein by exposure to weak magnetic fields].
It was found that weak magnetic fields (constant 42 microT; variable 0.05 microT; summation of frequencies in the range of 3.58-4.88 Hz) substantially (approximately fourfold) accelerate the hydrolysis of the amyloid beta-protein in aqueous solution. A region of the amyloid beta-protein most sensitive to the action of weak magnetic fields was determined. It is localized between Asp and Ser amino acid residues in positions 7 and 8 of the peptide sequence. It is in this region that the hydrolysis of the molecule of the amyloid beta-protein by the action of magnetic fields predominantly takes place.
Fesenko
E E
EE
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290 Russia.
Novikov
V V
VV
Bobkova
N V
NV
D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000528:radiation effects*; D002851:Chromatography, High Pressure Liquid; D004574:Electromagnetic Fields; D006868:Hydrolysis
D016229:Amyloid beta-Peptides