Antioxidant effects in the quinone fraction from Auxemma oncocalyx TAUB.
In previous studies in vitro we showed that the quinone fraction (QF) from the heartwood of Auxemma oncocalyx TAUB. presented antiplatelet and antioxidant activities. In the present work, the QF antioxidant property was evaluated in models of CCl(4)-induced hepatotoxicity in rats, and prolongation of pentobarbital-induced sleeping time in mice. Our results showed that levels of plasma glutamate-pyruvate-transaminase (GPT), as well as glutamate-oxalate-transaminase (GOT), were increased by the administration of CCl(4). On the other hand, only GPT levels were reduced by the QF treatment. Pentobarbital sleeping time was prolonged by the administration of CCl(4) and reduced by the QF treatment. Moreover, QF did not alter the pentobarbital-induced sleeping time. In conclusion, we showed that QF, represented mainly by oncocalyxone A, has hepatoprotective activity, and this effect is at least in part due to the antioxidant activity of this quinone.
Departamento de Farmácia, Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Rodolfo Teófilo, Brasil.
Maria Augusta Drago
MA
Ferreira
Osmar Del Rio Holanda
Odel R
Nunes
Luzia Kalyne Almeida Moreira
LK
Leal
Otília Deusdenia Loiola
OD
Pessoa
Telma Leda Gomes De
TL
Lemos
Glauce Socorro de Barros
GS
Viana
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D028082:Boraginaceae / Q000737:chemistry*; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D018547:Plant Stems; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology; D011809:Quinones / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000187:drug effects
D000975:Antioxidants; D010936:Plant Extracts; D020011:Protective Agents; D011809:Quinones