Gene therapy for hematological malignancies.
Since cancer is the result of genetic mutations, it should be well suited for correction through gene therapy. Hematological malignancies in which human gene transfer has been performed are leukemias, lymphomas, graft-versus host disease after allogeneic bone marrow transplantation in leukemia, and multiple myeloma. Gene therapy may be used to induce or enhance an antitumor immunological reaction, to correct a genetic defect in the tumor cells, to render the malignant disease more susceptible to conventional therapies, to make the normal host cells more resistant to conventional therapies, or to track cells used for therapy. Gene therapy will probably be most valuable for the eradication of minimal residual disease after the use of conventional therapies.
Medizinische Klinik und Poliklinik I, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
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Schmidt-Wolf
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Schmidt-Wolf
D017209:Apoptosis; D019496:Cancer Vaccines / Q000008:administration & dosage; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006086:Graft vs Host Disease; D019337:Hematologic Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans
D019496:Cancer Vaccines