Antifungal activity of a thiophene polyine from Leuzea carthamoides.
The thiophene polyine (E)-2-[5-(hept-5-en-1,3-diynyl)-thien-2-yl]-ethan-1,2-diol was isolated from an ethanolic extract of underground parts of Leuzea carthamoides. The thiophene polyine demonstrated significant antifungal activity against all tested species.
Chobot
V
V
Department of Pharmaceutical Botany and Ecology, Charles University, Faculty of Pharmacy, Heyrovského 1203, Hradec Králové 500 05, Czech Republic.
Buchta
V
V
Jahodárová
H
H
Pour
M
M
Opletal
L
L
Jahodár
L
L
Harant
P
P
D020095:Absidia / Q000187:drug effects; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001230:Aspergillus / Q000187:drug effects; D019659:Asteraceae; D002175:Candida / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013876:Thiophenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D010936:Plant Extracts; D013876:Thiophenes