Meta-analysis of dioxin cancer dose response for three occupational cohorts.
This article presents a meta analysis of data from three cohorts occupationally exposed to TCDD and related compounds. A statistically significant (p = 0.02) trend was found in total cancer mortality with increasing dioxin exposure. The trend tests show an increase in total cancer at cumulative TEQ (unit of measurement for TCDD-like compounds that is defined as the amount of TCDD that would produce the same toxicity as a mixture of TCDD-like compounds) serum levels that would result from lifetime intake of 7 pg TEQ/kg body weight/day, with no increase at 6 pg/kg/day. A linear dose response provided a good fit to the combined data and predicted an ED(01) (dioxin exposure resulting in a 0.01 increase in lifetime risk of cancer mortality) of 45 pg/kg/day (95% confidence interval, 21-324). The U.S. Environmental Protection Agency estimates that current lifetime human exposures to dioxin average approximately 1 pg/kg/day (99% percentile: 3 pg/kg/day). Although it appears unlikely that current exposures through foods would reach either 7 pg/kg/day or the ED(01), our analysis argues for careful consideration of the upper ranges of long-term average exposures for dioxins.
Crump
Kenny S
KS
Environ International Corporation, Ruston, Louisiana 71270, USA. kcrump@environcorp.com
Canady
Richard
R
Kogevinas
Manolis
M
D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D005506:Food Contamination; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality; D016273:Occupational Exposure; D016017:Odds Ratio; D012016:Reference Values; D018570:Risk Assessment