Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression.
Changes in cell-cell and cell-matrix adhesion accompany the transition from benign tumours to invasive, malignant cancer and the subsequent metastatic dissemination of tumour cells. This review discusses a possible role of cell adhesion molecules not only in redirecting a tumour cell's adhesive capabilities but also in modulating intracellular signalling, and with it, tumour malignancy.
Christofori
Gerhard
G
Institute of Biochemistry and Genetics, Department of Clinical-Biological Sciences, University of Basel, Vesalgasse 1, Switzerland. gerhard.christofori@unibas.ch
D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology*; D018450:Disease Progression; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D016023:Integrins / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D015820:Cadherins; D006133:Growth Substances; D018960:Hyaluronan Receptors; D016023:Integrins; D019006:Neural Cell Adhesion Molecules; D017468:Receptors, Fibroblast Growth Factor; D020794:Receptor Protein-Tyrosine Kinases