Flow-injection determination of ornidazole by chemiluminescence detection based on a luminol-ferricyanide reaction.
A flow-injection analysis (FIA) with a chemiluminescence detection method was developed for the determination of ornidazole based on the inhibition intensity of chemiluminescence from the luminol-ferricyanide system. Under the condition of 1.0 x 10(-3) mol/L luminol and 5.0 x 10(-6) mol/L potassium ferricyanide, the response to the concentration of omidazole is linear from 0.2 microg ml(-1) to 10 microg ml(-1), and a detection limit of 0.05 microg ml(-1) can be obtained. This method has been successfully applied to the determination of omidazole in pharmaceutical preparations.
Institute of Analytical Science, Department of Chemistry, Southwest Normal University, Beibei, Chongqing 400715, PR China.
Yi
Y
Lv
Zhujun
Z
Zhang
Deyong
D
He
Yufei
Y
Hu
D000890:Anti-Infective Agents / Q000032:analysis*; D005292:Ferricyanides / Q000737:chemistry*; D017022:Flow Injection Analysis; D008163:Luminescent Measurements; D008165:Luminol / Q000737:chemistry*; D009950:Ornidazole / Q000032:analysis*; D012972:Sodium Hydroxide / Q000737:chemistry
D000890:Anti-Infective Agents; D005292:Ferricyanides; C007931:hexacyanoferrate III; D012972:Sodium Hydroxide; D008165:Luminol; D009950:Ornidazole