Large volume donor plasmapheresis in inherited thrombophilia implicated in arterial thrombosis.
BACKGROUND
Life-threatening complications following apheresis are rare, and include venous thrombosis. Arterial thrombosis following apheresis has not been reported.


METHODS
A 48 year old donor had cerebral infarction following large volume plasma donation. The outcome was fatal. He was found to be heterozygous for both methylene tetrahydrofolate reductase (MTHFR) 677C-T mutation and Prothrombin 20210G-A allele.


CONCLUSIONS
This case suggests that large volume plasma donation may trigger arterial thrombotic events in inherited thrombophilia. Therefore, the effects of plasmapheresis on coagulation system should be studied thoroughly.
Department of Hematology, Karadeniz Technical University Hospital, Trabzon, Turkey. eovali@superonline.com
Ercüment
E
Ovali
Siret
S
Ratip
Mehmet
M
Ozmenoglu
S Sami
SS
Karti
Fahri
F
Uçar
Kubilay
K
Ukinç
Mustafa
M
Yilmaz
Polat
P
Koşucu
D001158:Arteries / Q000473:pathology; D001782:Blood Donors; D002544:Cerebral Infarction / Q000209:etiology; D005192:Family Health; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D008875:Middle Aged; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics; D010956:Plasmapheresis / Q000009:adverse effects*; D017354:Point Mutation; D011516:Prothrombin / Q000235:genetics; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics; D013927:Thrombosis / Q000209:etiology*
D011516:Prothrombin; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)