[Antiherpetic activity of l-lysine-alpha-oxidase in different dosage forms].
The antiviral effect of different medicinal forms on base of L-lysin-alpha-oxidase (LO) in treatment of experimental keratits and skin diseases induced by herpes simplex virus type 1 (HSV-1) at the rabbits was examined. Treatment with gel form of LO was more effective in comparison with water solution form of LO. This effect was tested by morphological, histological and immunoblotting methods in dynamics of viral disease.
Selishcheva
A A
AA
N. F. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, People's Friendship University of Russia, Moscow.
Alekseev
S B
SB
Smirnova
I P
IP
Podboronov
V M
VM
D000287:Administration, Topical; D000594:Amino Acid Oxidoreductases / Q000627:therapeutic use*; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D005782:Gels; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D016849:Keratitis, Herpetic / Q000188:drug therapy*; D011817:Rabbits; D017193:Skin Diseases, Viral / Q000188:drug therapy*; D012996:Solutions
D000998:Antiviral Agents; D005782:Gels; D012996:Solutions; D000594:Amino Acid Oxidoreductases; C041123:L-lysine oxidase