Adsorption of an amine drug onto microcrystalline cellulose and silicified microcrystalline cellulose samples.
The adsorption of a model amine drug (tacrine hydrochloride) from aqueous solution onto 21 microcrystalline cellulose (MCC) based samples has been investigated. The MCC source (manufacturer) affected adsorption. The adsorption appeared to be fully reversible. Adsorption was reduced by the use of high-density grade MCC, high-energy milling, and silicification. Adsorption of the model drug was not affected by the particle size of the MCC. Significant variations of the adsorption characteristics between batches of certain MCC products were found. The primary mode of adsorption was by ion exchange.
Steele
D Fraser
DF
Pharmaceutical Technology Research Group, Department of Pharmacy & Pharmacology, University of Bath, Bath, UK. d.f.steele@bath.ac.uk
Edge
Stephen
S
Tobyn
Michael J
MJ
Moreton
R Christian
RC
Staniforth
John N
JN
D000327:Adsorption; D002482:Cellulose; D002626:Chemistry, Pharmaceutical; D005079:Excipients; D010316:Particle Size; D013619:Tacrine / Q000008:administration & dosage*
D005079:Excipients; D013619:Tacrine; D002482:Cellulose; C109691:microcrystalline cellulose