Susceptibility loci for complex regional pain syndrome.
An association between HLA-DR13 and patients with complex regional pain syndrome (CRPS) who progressed towards multifocal or generalized tonic dystonia was recently reported. We now report on a new locus, centromeric in HLA-class I, which was significantly associated with a spontaneous development of CRPS, suggesting an interaction between trauma severity and genetic factors conferring CRPS susceptibility. Additionally, an association with the D6S1014 locus was found, supporting the previous finding of an association with HLA-DR13.
Department of Neurology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
Willem-Johan T
WJ
van de Beek
Bart O
BO
Roep
Arno R
AR
van der Slik
Marius J
MJ
Giphart
Bob J
BJ
van Hilten
D000293:Adolescent; D000328:Adult; D002874:Chromosome Mapping; D002875:Chromosomes; D020918:Complex Regional Pain Syndromes / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005805:Genes, MHC Class I; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics; D059810:HLA-DR Serological Subtypes; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D021141:Nucleic Acid Amplification Techniques / Q000379:methods; D014947:Wounds and Injuries / Q000235:genetics
D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C097337:HLA-DR13 antigen