[Segment duplications in subtelomeric regions of human chromosome 13].
Owing to a great progress in studying the human genome, its euchromatic portion is almost completely sequenced; the complete sequence is still unknown only for pericentric and telomeric regions and short arms of acrocentric chromosomes. Extended satellite blocks and segment duplications located in these regions substantially hinder the joining of the sequenced fragments and construction of the full-length genome map. The sequence was established for a 1.5-kb human chromosome 13 subtelomeric region, which is about 10 kb away from the rDNA cluster, and deposited in GenBank under accession no. AF478540. The region showed 83-84% homology to the pericentric region of human chromosome 19, and contained short fragments homologous to the pericentric region of human chromosome 13. The results may contribute to the current revision of genome evolution concepts in view of numerous segment duplications revealed.
Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia.
N S
NS
Kupriianova
D V
DV
Shibalov
A S
AS
Voronov
O V
OV
Muravenko
A V
AV
Zelenin
A P
AP
Ryskov
D002882:Chromosomes, Human, Pair 13; D002888:Chromosomes, Human, Pair 19; D003001:Cloning, Molecular; D003360:Cosmids; D020440:Gene Duplication; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D016615:Telomere / Q000235:genetics*