Serum level of the circulating angiogenesis inhibitor endostatin in patients with hyperthyroidism or hypothyroidism.
Serum level of endostatin, a natural angiogenesis inhibitor, was measured in 12 patients with hyperthyroidism and 9 patients with hypothyroidism. Control values were obtained from 12 healthy individuals. Hyperthyroidism was shown to be associated with an increased level of endostatin and hypothyroidism with a decreased endostatin level. There was no correlation of serum endostatin with thyroid hormone levels. Endostatin is a fragment of type XVIII collagen, and it is possible that reported changes are related to the effect of thyroid hormones on connective tissue metabolism.
Kucharz
Eugene J
EJ
Department of Internal Medicine and Rheumatology, Medical University of Silesia, Katowice, Poland. ekucharz@slam.katowice.pl
Kotulska
Anna
A
Kopeć
Magdalena
M
Stawiarska-Pieta
Barbara
B
Pieczyrak
Robert
R
D000328:Adult; D020533:Angiogenesis Inhibitors / Q000097:blood*; D003094:Collagen / Q000097:blood*; D043170:Collagen Type XVIII; D043169:Endostatins; D005260:Female; D006111:Graves Disease / Q000097:blood; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood*; D007037:Hypothyroidism / Q000097:blood*; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D012016:Reference Values; D013963:Thyroid Hormones / Q000097:blood
D020533:Angiogenesis Inhibitors; D043170:Collagen Type XVIII; D043169:Endostatins; D010446:Peptide Fragments; D013963:Thyroid Hormones; D003094:Collagen