[Own experiences in salvage chemotherapy of ovarian cancer--a preliminary report].
OBJECTIVE
To compare the efficacy and side effects of the ovarian cancer salvage treatment.


METHODS
28 patients from 2nd Department of Gynecology of Wrocław Medical University, treated for recurrent ovarian cancer in stage III and IV were analyzed. First line treatment after complete debulking operation was based on platinum analogue  (CAP). Platinum-sensitive patients were administered carboplatin with paclitaxel in the second line treatment. Platinum-resistant cases were treated with paclitaxel, topotecan or liposomal doxorubicin only.


RESULTS
The effectiveness of the salvage chemotherapy was similar. Side effects depended on used agent.


CONCLUSIONS
We conclude that the results of salvage treatment in ovarian cancer remain unsatisfactory. Introducing new agents into the therapy slightly improved the overall survival time.
Gerber
Jerzy
J
II Katedry i Kliniki Ginekologii, Akademii Medycznej we Wrocławiu.
Jedryka
Marcin
M
Gabryś
Marian
M
Goluda
Marian
M
D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D009944:Organoplatinum Compounds / Q000009:adverse effects; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods*; D013997:Time Factors; D019772:Topotecan / Q000008:administration & dosage; D016896:Treatment Outcome
D018906:Antineoplastic Agents, Alkylating; D000972:Antineoplastic Agents, Phytogenic; D009944:Organoplatinum Compounds; D019772:Topotecan; D004317:Doxorubicin; D016190:Carboplatin; D017239:Paclitaxel