Finding Canadian cancer clinical trials on the Internet: an exploratory evaluation of online resources.
BACKGROUND
Online information about the availability of clinical trials promises to enhance the accrual of patients into trials. The primary objective of our study was to assess the completeness of online databases of breast cancer clinical trials available in Canada.


METHODS
Eligible online resources were identified through a search of MEDLINE (articles published from 1966 to January 2002), an Internet search with Google, examination of Web sites of cancer organizations and information from experts. Resources were included if they contained information about open, active cancer clinical trials available in Canada. Web sites reviewed were not limited to those based in Canada. For each eligible resource, the number of listed trials and the proportion of trials identified were calculated.


RESULTS
Of 30 Web sites identified, 8 met all of the inclusion criteria; 3 were based in Canada and 5 in the United States. The total number of breast cancer trials identified as being available in Canada was 28. The Physician Data Query (PDQ) Clinical Trials Database of the US National Cancer Institute (cancer.gov/search/clinical_trials) identified 86% (24/28). The database of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) (ctg.queensu.ca) identified 29% (8/28) of the available breast cancer trials. CenterWatch Clinical Trials Listing Service (centerwatch.com) identified 4% (1/28).


CONCLUSIONS
If the PDQ database included all of the NCIC CTG trials, it would become the most complete database of breast cancer clinical trials currently available in Canada. Online cancer data sources should strive to make access to clinical trials simpler and more reliable, particularly for residents of the country where the trial is to be conducted.
Ontario Cancer Institute, University Health Network, and the Department of Medical Biophysics, University of Toronto, Toronto, Ont.
James E
JE
Till
Robert A
RA
Phillips
Alejandro R
AR
Jadad
D002170:Canada; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D004059:Diffusion of Innovation; D006801:Humans; D020407:Internet; D009369:Neoplasms