Dopamine D2 receptor TaqIA and TaqIB polymorphisms in Parkinson's disease.
In a case control study, we examined the association of DRD2 Taq1A and Taq1B polymorphisms and risk of PD, and evaluated the strength of linkage disequilibrium of the polymorphisms. The Taq1A and Taq1B polymorphisms were in strong linkage disequilibrium. There was, however, no significant association of the two polymorphisms with PD.
Department of Neurology, Singapore General Hospital, Singapore. gnrtek@sgh.com.sg
Eng-King
EK
Tan
Yanni
Y
Tan
Anthea
A
Chai
Christopher
C
Tan
Hui
H
Shen
Sau-Ying
SY
Lum
Stephanie M C
SM
Fook-Cheong
Mei-Ling
ML
Teoh
Yuan
Y
Yih
Meng-Cheong
MC
Wong
Yi
Y
Zhao
D000483:Alleles; D000704:Analysis of Variance; D017931:DNA Primers / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D019914:Taq Polymerase / Q000145:classification / Q000235:genetics*
D017931:DNA Primers; D005819:Genetic Markers; D017448:Receptors, Dopamine D2; D019914:Taq Polymerase