Evaluation of the mutagenicity of antimalarial products isolated from Solanum nudum (Solanaceae).
Diosgenone is a major component of the hexane extract from the plant Solanum nudum (Solanaceae). The products from degraded and acetylated diosgenone that showed in vitro antimalarial activity against the FCB-2 strain of Plasmodium falciparum and methanol, dichloromethane and ethereal extracts of Solanum nudum were tested for their mutagenic activity using the Ames test with the TA-97a, TA-98, TA-100 and TA-102 strains of Salmonella typhimurium. These compounds were not mutagenic at the tested concentrations.
Malaria Group, University of Antioquia, Medellín, Colombia.
A
A
Pabón
S
S
Blair
J
J
Carmona
M
M
Zuleta
J
J
Saez
D000107:Acetylation; D019943:Amino Acid Substitution; D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000633:toxicity*; D006639:Histidine / Q000737:chemistry; D066298:In Vitro Techniques; D009152:Mutagenicity Tests; D009153:Mutagens / Q000302:isolation & purification / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D032322:Solanum / Q000737:chemistry*; D013141:Spiro Compounds / Q000302:isolation & purification / Q000633:toxicity*; D014315:Triterpenes / Q000302:isolation & purification / Q000633:toxicity*
D000962:Antimalarials; D009153:Mutagens; D010936:Plant Extracts; D013141:Spiro Compounds; D014315:Triterpenes; C469690:diosgenone; D006639:Histidine