Diversity of the biosynthesis of the isoprene units.
This review covers the biosynthesis of the starter units of terpenoids, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) via the nonmevalonate pathway together with a new enzyme involved in the conversion of IPP and DMAPP, i.e type 2 IPP isomerase. The biosynthesis of terpenoids produced by actinomycetes is also reviewed. 117 references are cited.
Kuzuyama
Tomohisa
T
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan. kuz@iam.u-tokyo.ac.jp
Seto
Haruo
H
D000190:Actinomyces / Q000378:metabolism*; D002070:Butadienes / Q000737:chemistry / Q000378:metabolism*; D019748:Carbon-Carbon Double Bond Isomerases / Q000378:metabolism*; D045782:Hemiterpenes; D008798:Mevalonic Acid / Q000737:chemistry / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000378:metabolism*; D010420:Pentanes; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism*
D002070:Butadienes; D045782:Hemiterpenes; D009943:Organophosphorus Compounds; D010420:Pentanes; D013729:Terpenes; C005059:isoprene; C004809:isopentenyl pyrophosphate; D019748:Carbon-Carbon Double Bond Isomerases; C021453:isopentenyldiphosphate delta-isomerase; D008798:Mevalonic Acid