Expression of p65, DD3 and c-erbB2 genes in prostate cancer.
The expression of p65, DD3 and c-erbB2 genes was analyzed in 39 histologically verified human prostate cancers. The expression of p65 and DD3 genes was observed in significant percentage in well- and moderately-differentiated tumors. Both genes expression was lower in poorly differentiated tumors. On the contrary, c-erbB2 gene expression increased with advanced histological grading and reached the highest percentage in poorly-differentiated cancers. In the all investigated groups straight dependence between p65 and DD3 genes expression occurred. Opposite dependence was noticed in expression of p65/DD3 and c-erbB2 genes.
Department of Pharmaceutical Biochemistry; Molecular Biology Laboratory, 90-151 Lodz, Poland.
E
E
Balcerczak
M
M
Mirowski
A
A
Sasor
R
R
Wierzbicki
D002352:Carrier Proteins / Q000235:genetics*; D015870:Gene Expression; D018734:Genes, erbB-2; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D002352:Carrier Proteins; C484020:HSAJ2425 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins