Dendritic cells: controllers of the immune system and a new promise for immunotherapy.
The immune system is controlled by dendritic cells (DCs). Just as lymphocytes comprise different subsets, DCs comprise several subsets that differentially control lymphocyte function. In humans, the myeloid pathway includes Langerhans cells (LCs) and interstitial DCs (intDCs). While both subsets produce IL-12, only intDCs make IL-10 and induce B cell differentiation. Another pathway includes plasmacytoid DCs, which promptly secrete large amounts of IFN-alpha/beta viral encounter. Thus, insights into in vivo DC functions are important to understand the launching and modulation of immunity.
Banchereau
Jacques
J
Baylor Institute for Immunology Research, Dallas, Texas 75204, USA.
Paczesny
Sophie
S
Blanco
Patrick
P
Bennett
Lynda
L
Pascual
Virginia
V
Fay
Joseph
J
Palucka
A Karolina
AK
D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D014612:Vaccines / Q000276:immunology
D014612:Vaccines