New silyl ether reagents for the absolute stereochemical determination of secondary alcohols.
[reaction: see text] Herein we report a new set of silyl ether reagents for determining the enantiomeric purity and absolute stereochemistry of secondary alcohols. These derivatives are easily synthesized, provide straightforward spectroscopic results, and allow for facile recovery of the original chiral alcohol.
Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA. williar@wyeth.com
R Thomas
RT
Williamson
Ana C
AC
Barrios Sosa
Abhijit
A
Mitra
Pamela J
PJ
Seaton
Douglas B
DB
Weibel
Frank C
FC
Schroeder
Jerrold
J
Meinwald
Frank E
FE
Koehn
D000438:Alcohols / Q000737:chemistry*; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D004987:Ethers; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism
D000438:Alcohols; D004987:Ethers; D007202:Indicators and Reagents