Plasma motilin in untreated celiac disease.
Celiac disease (CD) is characterized by mucosal villous atrophy mostly confined to the proximal small intestine. Upper-gut motor abnormalities have been reported. Motilin, localized in cells in the proximal small intestine, is a trigger factor for the migrating motor complex. Plasma levels of motilin were studied in 16 untreated CD patients and in an age-matched control group of 18 healthy subjects by radioimmunoassay and by high-performance liquid chromatography (HPLC). The fasting levels of motilin and postprandial levels were significantly higher in CD patients compared to controls (P<0.01) and HPLC revealed a divergent individual pattern of the motilin fragments.
Department of Internal Medicine, Lund University Hospital, S-22185 Lund, Sweden. kristina.sjolund@med.lu.se
K
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Sjölund
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R
Ekman
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002446:Celiac Disease / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009037:Motilin / Q000097:blood*; D019518:Postprandial Period; D011863:Radioimmunoassay
D009037:Motilin