Surgical clinical trials in melanoma.
Over the past 30 years, several important surgery clinical trials examining the issues of excision margins, ELND, and regional therapy have given rise to the current practice guidelines for the care of melanoma patients. The development of the SLN selective lymphadenectomy concept and the increasing use of molecular staging techniques have presented new challenges in this field. Clinical trials have been initiated to address these latest issues. In the next decade, these trials should help guide the integration of the new technologies into the surgical management of melanoma.
Bedrosian
Isabelle
I
Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Gershenwald
Jeffrey E
JE
D000970:Antineoplastic Agents / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D010478:Chemotherapy, Cancer, Regional Perfusion; D002986:Clinical Trials as Topic; D005121:Extremities; D006801:Humans; D008197:Lymph Node Excision; D008545:Melanoma / Q000517:prevention & control / Q000556:secondary / Q000601:surgery*; D015337:Multicenter Studies as Topic; D009367:Neoplasm Staging; D012878:Skin Neoplasms / Q000473:pathology / Q000517:prevention & control / Q000601:surgery*; D013548:Sweden; D016896:Treatment Outcome; D006113:United Kingdom
D000970:Antineoplastic Agents