Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.
Division of Infectious Diseases & Pulmonary/Critical Care Medicine, 6301 MSRB III, Ann Arbor, MI 48109-0642, USA.
David M
DM
Aronoff
Olivier
O
Boutaud
Lawrence J
LJ
Marnett
John A
JA
Oates
D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D011451:Prostaglandin-Endoperoxide Synthases / Q000737:chemistry / Q000378:metabolism*; D012459:Salicylates / Q000494:pharmacology*
D016861:Cyclooxygenase Inhibitors; D008054:Lipid Peroxides; D012459:Salicylates; D011451:Prostaglandin-Endoperoxide Synthases