[Differentiation of human pancreatic endocrine cells in the period of fetal development].
The stereological analysis of electron micrographs of pancreatic endocrine cells (A and B) obtained from human fetuses at gestational months 4 to 7 was performed to assess the volume densities of membranous organelles (mitochondria, rough endoplasmic reticulum, Golgi complex), polysomes and secretory granules. The differences were established in the ratios of the volume densities of organelles and secretory granules in the process of differentiation. The morphometric characteristics of total A- and B-cell populations as well as the quantitative data on the structural organization of endocrine cells at various stages of differentiation are presented.
Department of Biomedical Research, Central Scientific Research Laboratory, St. Petersburg I.I. Metchnikov State Medical Academy.
A A
AA
Puzyrev
V F
VF
Ivanova
D002454:Cell Differentiation / Q000502:physiology*; D048429:Cell Size; D005314:Embryonic and Fetal Development / Q000502:physiology*; D006801:Humans; D007515:Islets of Langerhans / Q000166:cytology / Q000196:embryology / Q000648:ultrastructure; D008854:Microscopy, Electron