[The scaling method of spatial distribution of keratinocytes in the basal layer of epidermis in norm and during the development of psoriatic lesion].
On the basis of the modern conceptions postulating that the growing layer of normal epidermis contains two populations of keratinocytes differing greatly in the rate of mitotic division (stem and transient cells), a hypothesis was proposed that explains the reason for the establishment of the portion of the proliferating fraction close to 60%. A relationship between this value and the distribution of keratinocytes of the basal layer in space was demonstrated, and formulae for its calculation were derived. Possible pathways of the transition from the normal spatial configuration to the distribution typical for the focal lesion in psoriasis were analyzed when all stem cells begin to divide vigorously, and the size of the population of transient cells is 100%.
Nizhnii Novgorod Research Dermatovenerologic Institute, Ministry of Health of the Russian Federation, Nizhnii Novgorod, Russia.
M V
MV
Laptev
N K
NK
Nikulin
D000465:Algorithms; D002455:Cell Division; D004817:Epidermis / Q000473:pathology*; D006801:Humans; D015603:Keratinocytes / Q000473:pathology*; D008954:Models, Biological; D011565:Psoriasis / Q000473:pathology*