Predictive value of brain-specific proteins in serum for neurodevelopmental outcome after birth asphyxia.
Brain-specific proteins have been used to detect cerebral injury after birth asphyxia. Previous investigations suggest that serum protein S-100beta, brain-specific creatine kinase (CK-BB), and neuron-specific enolase (NSE) are capable of identifying patients with a risk of developing hypoxic-ischemic encephalopathy. Whether detection of elevated serum concentrations of these proteins reflects long-term neurodevelopmental impairment remains to be investigated. We examined serum protein S-100beta, NSE, and CK-BB at 2, 6, 12, and 24 h after birth in 29 asphyxiated infants and 20 control infants. Neurodevelopmental follow-up examinations were performed at 20 mo of age using the German revision of the Griffiths scales for developmental assessment. Elevated concentrations of serum protein S-100beta, NSE, and CK-BB within 24 h after asphyxia did not correlate with long-term neurodevelopmental delay. We conclude that serum protein S-100beta, NSE, and CK-BB, sampled on the first day of life, is of limited value in predicting severe brain damage after birth asphyxia.
Nagdyman
Nicole
N
Department of Neonatology, Charité Virchow University Hospital, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. nicole.nagdyman@charite.de
Grimmer
Ingrid
I
Scholz
Tristess
T
Muller
Christian
C
Obladen
Michael
M
D001238:Asphyxia Neonatorum / Q000097:blood* / Q000175:diagnosis*; D015415:Biomarkers; D003402:Creatine Kinase / Q000097:blood*; D052276:Creatine Kinase, BB Form; D002658:Developmental Disabilities / Q000097:blood / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D009414:Nerve Growth Factors; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011237:Predictive Value of Tests; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*
D015415:Biomarkers; D007527:Isoenzymes; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D003402:Creatine Kinase; D052276:Creatine Kinase, BB Form; D010751:Phosphopyruvate Hydratase