[Diagnosis and treatment of invasive pulmonary aspergillosis in malignant hematological diseases-3 cases reported].
Invasive pulmonary aspergillosis is difficult to diagnose and a critical ill with high mortality. In this paper, the diagnosis and treatment of invasive pulmonary aspergillosis complicated in 3 cases of hematological malignancy (2 acute leukemias and 1 MDS-RA) were retrospectively analysed. All patients had histories of hypoimmunity and were received prophylactic antifungal treatment. Pulmonary aspergillosis infection still occurred and confirmedly diagnosed by sputum examination. After 7 to 14 days of combination treatment of liposomal amphotericin B, itraconazole and flucytosine, 2 cases were cured and another showed effective. In conclusion, early diagnosis and treatment of invasive pulmonary aspergillosis are very critical and the therapeutic effectiveness of combined scheme with liposomal amphotericin B, itraconazole and flucytosine is very effective for pulmonary aspergillosis.
Qiao
Jian-Hui
JH
Department of Hematology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100039, China. qiaojh@vip.sina.com
Sun
Wan-Jun
WJ
Yu
Chang-Lin
CL
Wang
Dan-Hong
DH
Guo
Mei
M
Zhang
Shi
S
Liu
Fang
F
Ai
Hui-Sheng
HS
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000753:Anemia, Refractory / Q000150:complications*; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
C068538:liposomal amphotericin B; D000666:Amphotericin B