Complete regression of bone metastases on super bone scan, by low-dose cisplatin, UFT, diethylstilbestrol diphosphate, and dexamethasone in a patient with hormone-refractory prostate cancer.
Many types of chemotherapy are now being attempted all over the world for hormone-refractory prostate cancer (HRPC) patients, and prostate-specific antigen (PSA) reduction in almost half of the treated patients has been reported. However, only a few studies have reported the response of bone metastasis. The authors report a patient with HRPC who obtained complete regression of bone metastases on super bone scan by biochemical modulation (BM), dexamethasone, and endocrine therapy.
Hoshi
Senji
S
Department of Urology, Yamagata Prefectural Hospital, 1800 Aoyagi, Yamagata 990-2292, Japan. hoshi@uro.med.tohoku.ac.jp
Ohyama
Chikara
C
Hagisawa
Shigeru
S
Ono
Kunio
K
Satoh
Makoto
M
Saito
Seiichi
S
Fukuzaki
Atushi
A
Arai
Yoichi
Y
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D019008:Drug Resistance, Neoplasm; D005500:Follow-Up Studies; D006728:Hormones; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D011877:Radionuclide Imaging; D018570:Risk Assessment; D005641:Tegafur / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014498:Uracil / Q000008:administration & dosage
D018931:Antineoplastic Agents, Hormonal; D006728:Hormones; D005641:Tegafur; D014498:Uracil; D004054:Diethylstilbestrol; D003907:Dexamethasone; C004955:fosfestrol; D017430:Prostate-Specific Antigen; D002945:Cisplatin