[Effect of hyperthermia on the red-cell immune function of rats and its teratogenicity on developing embryos].
After rats on gestation day 10 exposed to hyperthermia(40 degrees C) for 0.5, 1.0, 2.5 and 5.0 h, red-cell C3b receptor activity(aggregate), red-cell immune complex, circulating immune complex, Nile blue sulfate (NBS) vital staining, electronic microscope and histochemical techniques were used in investigate whether the hyperthermia was disturb red-cell immune functions of pregnant rats and played some role in teratogenesis. The results showed that hyperthermia increased the level of red-cell C3b receptor activity, red-cell immune complex and circulating immune complex. On the other hand, many of them also decreased to normal level after rats were placed in room temperature for 20 h. Following the extension of hyperthermic exposure, the teratogenic incidence increased from 0.9%(1/117) to 18.3%(22/120), in apparent time-effect relationship, when pregnant rats of gestation day 11.5 were killed. It was found that hyperthermia induced.
Zhu
X A
XA
Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Urumuqi 830000, China.
Li
Y
Y
D000818:Animals; D000936:Antigen-Antibody Complex / Q000097:blood; D004247:DNA / Q000378:metabolism; D004622:Embryo, Mammalian / Q000737:chemistry; D005314:Embryonic and Fetal Development; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects*; D008297:Male; D011247:Pregnancy; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017463:Receptors, Complement 3b / Q000097:blood*
D000936:Antigen-Antibody Complex; D011506:Proteins; D017463:Receptors, Complement 3b; D004247:DNA