B7-H1 pathway and its role in the evasion of tumor immunity.
B7-H1 is a recently identified member of the B7 family molecules. Upon ligation to its receptors on T cells it regulates activation and differentiation of T cells. B7-H1 preferentially costimulates IL-10 production in resting T cells and further induces the apoptosis of activated T cells. PD-1 is a receptor of B7-H1 and is shown to mediate the inhibition of activated T cell response, presumably by inhibiting cell cycle progression. The expression of B7-H1 protein is limited to macrophage lineage of cells in normal tissues, although its mRNA transcription is found in a broad range of tissues. In contrast, B7-H1 is abundant in various human cancers. The tumor-associated B7-H1 increases apoptosis of antigen specific T cells, leading to growth of immunogenic tumor growth in vivo. Current data suggest that B7-H1 regulates the organ-specific tolerance in normal tissue and may contribute to immune evasion by cancers. Selective manipulation of B7-H1 pathway thus aids in the design of new regimens in the treatment of human autoimmune disease and the control of malignant cancers.
Dong
Haidong
H
Department of Immunology, Mayo Medical and Graduate Schools, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.
Chen
Lieping
L
D015703:Antigens, CD; D018122:B7-1 Antigen / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D060890:B7-H1 Antigen; D001798:Blood Proteins; D003110:Colonic Neoplasms / Q000276:immunology; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D008562:Membrane Glycoproteins; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D010051:Ovarian Neoplasms / Q000276:immunology; D010455:Peptides; D011971:Receptors, Immunologic / Q000502:physiology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology
D015703:Antigens, CD; D018122:B7-1 Antigen; D060890:B7-H1 Antigen; D001798:Blood Proteins; C423236:CD274 protein, human; D008562:Membrane Glycoproteins; D010455:Peptides; D011971:Receptors, Immunologic