[A case of advanced gastric cancer with peritoneal metastases responding to bi-weekly paclitaxel therapy].
A 68-year-old man underwent bypass operation for gastric cancer, because the tumor was judged to be unresectable due to peritoneal dissemination. After the operation, the patient was treated with daily oral administration of 100 mg TS-1 for two weeks followed by one week rest as one cycle. However, symptoms such as anemia, ascites and edema became worse and the TS-1 resulted in progressive disease. Bi-weekly paclitaxel therapy (80 mg/m2/2 weeks) was then chosen as second line chemotherapy. Anemia and edema were reduced and computed tomography showed shrinkage in the size of lymph nodes and disappearance of ascites. Only grade 1 alopecia was observed as an adverse event during the therapy. Bi-weekly paclitaxel therapy could be safe and useful as the second line therapy.
Dept. of Surgery, Tottori Red Cross Hospital.
Yumi
Y
Yamaguchi
Kenjiro
K
Taniguchi
Takuji
T
Naka
Shunsuke
S
Shibata
Minoru
M
Ishiguro
Eiichi
E
Yurugi
Hideaki
H
Nishidoi
Hirofumi
H
Kudoh
Satoshi
S
Murakami
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage*; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel