Effects of sibutramine on binge eating, hunger, and fullness in a laboratory human feeding paradigm.
OBJECTIVE
The purpose of this study was to evaluate the effects of sibutramine vs. placebo on binge-eating behavior, hunger, and satiety in patients who had problems with binge eating.


METHODS
Seven adult subjects who had problems with binge eating (mean age, 42 years) were randomly assigned to receive alternating sibutramine and placebo in a double-blind placebo-controlled crossover study. This involved two 4-week dosing periods separated by a 2-week washout.


RESULTS
Subjects lost weight on sibutramine but not on placebo. There was a significant difference in the number of kilocalories consumed between the sibutramine and placebo conditions, with a significant reduction of intake during binge-eating episodes on sibutramine.


CONCLUSIONS
Sibutramine suppresses intake during binge-eating episodes. This effect is demonstrable in a human feeding laboratory paradigm.
The Neuropsychiatric Research Institute and the University of North Dakota School of Medicine and Health Sciences, Fargo, North Dakota, USA. mitchell@medicine.nodak.edu
James E
JE
Mitchell
Blake A
BA
Gosnell
James L
JL
Roerig
Martina
M
de Zwaan
Stephen A
SA
Wonderlich
Ross D
RD
Crosby
Melissa A
MA
Burgard
Beth N
BN
Wambach
D000328:Adult; D001067:Appetite Depressants / Q000494:pharmacology*; D002032:Bulimia / Q000188:drug therapy*; D018592:Cross-Over Studies; D003503:Cyclobutanes / Q000494:pharmacology*; D004311:Double-Blind Method; D004435:Eating / Q000187:drug effects*; D005260:Female; D006801:Humans; D006815:Hunger / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D012528:Satiety Response / Q000187:drug effects*; D015431:Weight Loss / Q000187:drug effects
D001067:Appetite Depressants; D003503:Cyclobutanes; C058254:sibutramine