A longitudinal study on smoking in relationship to fitness and heart rate response.
OBJECTIVE
Smoking has been shown to be associated with impaired cardiovascular fitness and reduced heart rate response to exercise. It is not known whether these associations are present in adolescence and young adults, and whether they change over time.


METHODS
Maximal oxygen uptake ([OV0312]O(2max)), maximum treadmill slope (Slope(max)), resting heart rate (HR(rest)), heart rate at submaximal exercise (HR(submax)), heart rate reserve (HRR), and maximum heart rate (HR(max)) were measured one to nine times between ages 13 and 36 in 298 male and 334 female participants of the Amsterdam Growth and Health Longitudinal Study. Generalized estimating equation analyses were used to study the longitudinal relationship between smoking and cardiovascular fitness and heart rate response to exercise, whereas linear regression analyses were used to study the reversibility of smoking effects at age 36.


RESULTS
Moderate to heavy smoking (>/=10 g of tobacco per day) was longitudinally and negatively related to [OV0312]O(2max), Slope(max), HR(submax), and HR(max). With increasing age, the negative relationship between smoking and [OV0312]O(2max), Slope(max), and HR(max) became stronger in males. Cross-sectional analyses suggested that the adverse effects of smoking were reversible in 36-yr-old males.


CONCLUSIONS
Cardiovascular fitness and heart rate response to exercise are already reduced in young healthy smokers. In men, the adverse effects of smoking become stronger with increasing age but appear to be reversible at age 36.
Bernaards
Claire M
CM
Institute for Research in Extramural Medicine (EMGO), VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.
Twisk
Jos W R
JW
Van Mechelen
Willem
W
Snel
Jan
J
Kemper
Han C G
HC
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002320:Cardiovascular Physiological Phenomena; D015331:Cohort Studies; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D009426:Netherlands; D010101:Oxygen Consumption; D010809:Physical Fitness / Q000502:physiology*; D011237:Predictive Value of Tests; D011336:Probability; D018570:Risk Assessment; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology