Overall survival is not a realistic end point for clinical trials of new drugs in advanced solid tumors: a critical assessment based on recently reported phase III trials in colorectal and breast cancer.
Di Leo
Angelo
A
Bleiberg
Harry
H
Buyse
Marc
M
D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D017326:Clinical Trials, Phase III as Topic; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D015986:Confounding Factors, Epidemiologic; D006801:Humans; D009362:Neoplasm Metastasis; D016019:Survival Analysis; D016896:Treatment Outcome