Shock-like sensations during venlafaxine withdrawal.
Electric shock-like sensations may occur after cessation of treatment with serotonin selective reuptake inhibitors but are reported in the literature only rarely with discontinuation of venlafaxine. Two patients experienced severe shock-like sensations during venlafaxine withdrawal. For both patients symptoms occurred with lowering of the dosage and persisted for 5 days after complete discontinuation of the drug. These sensations may represent significant alteration of neuronal activity in the central nervous system.
Department of Psychiatry, Montgomery VA Medical Center, and the School of Medicine, University of Mississippi, Jackson, Mississippi 39216, USA. roy.reeves@med.va.gov
Roy R
RR
Reeves
James E
JE
Mack
John J
JJ
Beddingfield
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000009:adverse effects*; D003511:Cyclohexanols / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012678:Sensation Disorders / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D000069470:Venlafaxine Hydrochloride
D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D000069470:Venlafaxine Hydrochloride