Paraneoplastic eosinophilic fasciitis: a case report.
A 60-year-old white woman with polycythemia rubra vera post splenectomy in November 2001 was found to have peripheral white blood cell counts increasing over 3 months. Cytogenetics revealed trisomy of chromosomes 8 and 9, and bone marrow biopsy showed hypercellular, fibrotic bone marrow consistent with myelofibrosis of polycythemia rubra vera. Two months later, the patient developed acute swelling and pain in her lower extremities. The clinical symptoms along with confirmatory histology supported the diagnosis of eosinophilic fasciitis. This is the first reported case in the English literature of an association between polycythemia vera and eosinophilic fasciitis.
Jacob
Sharon E
SE
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, FL 33125, USA.
Lodha
Rashmi
R
Cohen
Jonathan J
JJ
Romanelli
Paolo
P
Kirsner
Robert S
RS
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004802:Eosinophilia / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D005208:Fasciitis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D016898:Interferon-alpha / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D011087:Polycythemia Vera / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D055728:Primary Myelofibrosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D013156:Splenectomy / Q000009:adverse effects; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D016898:Interferon-alpha; D008775:Methylprednisolone; D006918:Hydroxyurea