Tools and techniques for craniofacial tissue engineering.
Craniofacial surgery is an important conduit for tissue-engineering applications. As interdisciplinary collaborations improve, we can expect to see remarkable progress in de novo tissue synthesis, replacement, and repair. Ultimately, we may one day find that gene-modified cell-based tissue-engineering strategies will succeed today's reconstructive strategies. In this review, we highlight the major gene- and cell-based preclinical tools and techniques that are currently being developed to solve common craniofacial problems.
Department of Surgery, Stanford University School of Medicine, Stanford, California 94305-5148, USA.
Stephen M
SM
Warren
Kenton D
KD
Fong
Constance M
CM
Chen
Elizabeth G
EG
Loboa
Catherine M
CM
Cowan
H Peter
HP
Lorenz
Michael T
MT
Longaker
D000818:Animals; D017690:Cell Transplantation; D002478:Cells, Cultured / Q000637:transplantation; D019902:Chondrocytes / Q000637:transplantation; D019465:Craniofacial Abnormalities / Q000601:surgery / Q000628:therapy*; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors / Q000145:classification / Q000493:pharmacokinetics / Q000627:therapeutic use; D048091:Guided Tissue Regeneration / Q000295:instrumentation; D000882:Haplorhini; D006801:Humans; D051379:Mice; D023421:Models, Animal; D018919:Neovascularization, Physiologic; D010006:Osteoblasts / Q000502:physiology; D019857:Osteogenesis, Distraction; D019736:Prostheses and Implants; D011817:Rabbits; D051381:Rats; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*; D014162:Transfection