Inhibitory effect of Bergenia ligulata on influenza virus A.
Methanol water extract from rhizomes of Bergenia ligulata, a plant used in Nepalese ethnomedicine, inhibited in vitro the replication of influenza virus in a dose dependent manner and did not show virucidal activity at effective concentration. Pretreatment of cells with B. ligulata extract was shown to be most effective to prevent cell destruction. The extract inhibited viral RNA synthesis and reduced viral peptide synthesis at 10 microg/ml. The virus inhibitory effect is related to the presence of condensed tannins in the extract.
Rajbhandari
M
M
Department of Pharmaceutical Biology, Institute of Pharmacy, Ernst-Moritz-Arndt-University, Greifswald, Germany.
Wegner
U
U
Schöpke
T
T
Lindequist
U
U
Mentel
R
R
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D003124:Colorimetry; D004285:Dogs; D009980:Influenza A virus / Q000187:drug effects*; D009390:Nepal; D010946:Plants, Medicinal / Q000737:chemistry*; D012367:RNA, Viral / Q000096:biosynthesis; D031995:Saxifragaceae / Q000737:chemistry*; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D012367:RNA, Viral; D014764:Viral Proteins