Dorsolateral prefrontal lobe activation declines significantly with age--functional NIRS study.
Dorsolateral prefrontal cortex (DLPF) activation in response to cognitive paradigms engaging working memory was quantitatively evaluated using functional near infrared spectroscopy (fNIRS) in cognitively normal individuals across the age spectrum (20-90 years; 8 females, 52 males). DLPF activation score (DAS) demonstrated a significant decline (r(2) = -0561, p < 0.05) as a function of age. The study indicates that blood flow response associated with DLPF activation declines as a function of age in cognitively normal individuals and that fNIRS can be used as a convenient, portable tool for assessing such activation.
Kwee
Ingrid L
IL
Department of Neurology, University of California, Davis, VANCHCS, 150 Muir Road, Martinez, CA 94553, USA. ilkwee@ucdavis.edu
Nakada
Tsutomu
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000098:blood supply* / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D019265:Spectroscopy, Near-Infrared / Q000379:methods*