Palladium-catalyzed synthesis of novel optically active tryptophan analogues.
[reaction: see text] Both unsaturated proline derivatives and optically active tryptophan analogues have been obtained via Pd-catalyzed cyclization of aniline-containing acetylenic amino acids. The side chain length of the cyclization precursor determines which one of the two possible products will be formed.
van Esseveldt
Bart C J
BC
Departments of Organic and Inorganic Chemistry, NSRIM, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.
van Delft
Floris L
FL
de Gelder
René
R
Rutjes
Floris P J T
FP