Synthesis and antifungal activity of (+/-)-1-(5-aryl-3-pyridin-2-yl-4,5-dihydro-pyrazol-1-yl)-2-imidazol-1-yl-ethanone derivatives.
(+/-)-1-(5-Aryl-3-pyridin-2-yl-4,5-dihydro-pyrazol-1-yl)-2-imidazol-1-yl-ethanone derivatives were synthesized and tested for their in vitro antifungal activity. The compounds showed a moderate activity against strains of Candida parapsilosis, Candida pseudotropicalis and Candida glabrata.
Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa 1, I-34127, Trieste, Italy. mamolo@univ.trieste.it
Maria Grazia
MG
Mamolo
Daniele
D
Zampieri
Valeria
V
Falagiani
Luciano
L
Vio
Elena
E
Banfi
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D015195:Drug Design; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*
D000935:Antifungal Agents; D007093:Imidazoles; D011720:Pyrazoles; D011725:Pyridines