Peptidoglycan induces mobilization of the surface marker for activation marker CD66b in human neutrophils but not in eosinophils.
Peptidoglycan from Staphylococcus aureus mobilized CD66b in human neutrophils but did not upregulate surface activation markers in eosinophils. In addition, Toll-like receptor 2, implicated in the recognition of peptidoglycan, was detected on the surface of resting neutrophils but not on eosinophils. These findings suggest roles for neutrophils but not eosinophils in innate recognition of peptidoglycan.
Mattsson
Eva
E
Department of Infectious Diseases, University Hospital, Lund University, Lund, Sweden.
Persson
Terese
T
Andersson
Pia
P
Rollof
Jan
J
Egesten
Arne
A
D015703:Antigens, CD; D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D015415:Biomarkers; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D004804:Eosinophils / Q000187:drug effects; D058851:GPI-Linked Proteins; D006801:Humans; D008562:Membrane Glycoproteins / Q000032:analysis; D018375:Neutrophil Activation / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010457:Peptidoglycan / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000032:analysis; D013211:Staphylococcus aureus / Q000737:chemistry*; D051195:Toll-Like Receptor 2; D051193:Toll-Like Receptors; D015854:Up-Regulation
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D015415:Biomarkers; C504120:CEACAM8 protein, human; D015815:Cell Adhesion Molecules; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D010457:Peptidoglycan; D011956:Receptors, Cell Surface; C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2; D051193:Toll-Like Receptors