[Study of 125I-interleukin-8 distribution in mice].
IL-8 was radiolabeled with 125I via Bolten-Hunter agent and the distribution of 125I-IL-8 in mice was determined in order to understand IL-8 behaviors in vivo. The percentage of 125I-IL-8 in blood, heart, liver, lung, kidneys, bone and spleen was obtained. The half-clearance of fast phase T1/2 alpha and slow phase T1/2 beta were 0.32 h and 8.01 h respectively. Most of 125I-IL-8 was excluded by kidneys.
Fan
Wo
W
Department of Radiation Medicine, Suzhou University, Suzhou 215007.
Qian
Jianhua
J
Zhu
Ran
R
Xu
Yujie
Y
Zhang
Yi
Y
Zhu
Benxin
B
D000818:Animals; D016209:Interleukin-8 / Q000493:pharmacokinetics*; D007457:Iodine Radioisotopes; D008297:Male; D051379:Mice; D011994:Recombinant Proteins / Q000493:pharmacokinetics; D014018:Tissue Distribution
D016209:Interleukin-8; D007457:Iodine Radioisotopes; D011994:Recombinant Proteins