Korean medicinal plants inhibiting to human immunodeficiency virus type 1 (HIV-1) fusion.
In order to find novel anti-HIV agents from natural products, 80 MeOH extracts of Korean plants were applied to a syncytia formation inhibition assay, which is based on the interaction between the HIV-1 envelope glycoprotein gp120/41 and the cellular membrane protein CD4 of T lymphocytes. The most potent HIV-1 fusion inhibition was shown by the stem bark of Ailanthus altissima with 74.9 +/- 4.4% at a concentration of 100 microg/mL.
Chang
Young-Su
YS
College of Pharmacy, Chosun University, Kwangju 501-759, Republic of Korea.
Woo
Eun-Rhan
ER
D032268:Ailanthus; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007723:Korea; D008519:Medicine, Traditional; D008561:Membrane Fusion / Q000187:drug effects; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal
D019380:Anti-HIV Agents; D010936:Plant Extracts