Potential interference of agents on radioiodide thyroid uptake in the euthyroid rat.
The objective of this research was to investigate the merits of controlled studies with euthyroid rats as a means of determining the influence of dose and time after administration of agents that may interfere with radioiodide uptake in the thyroid.


METHODS
Potassium iodide (KI), propylthiouracil (PTU), diatrizoate meglumine, and iohexol were selected to represent interfering agents. Two dose levels per agent were investigated. Doses used were 1 and 2 mg/kg of body weight for KI, 3.5 and 7 mg/kg of body weight for PTU, 1 mL/kg (282 mg I/kg) and 2 mL/kg (564 mg I/kg) of body weight for diatrizoate meglumine, and 1 mL/kg (300 mg I/kg) and 2 mL/kg (600 mg I/kg) of body weight for iohexol. The 24-h radioiodide thyroid uptake was determined after (131)I was given at 1, 8, 15, and 22 d after administration of interfering agents.


RESULTS
The percentage radioiodide uptake value for the thyroid decreased significantly compared with controls for all agents and both doses on day 1 but returned to control levels by day 22 for all agents and both doses The time to return to normal varied between agents and doses.


CONCLUSIONS
We conclude that the interfering agent, the dose given, and the length of time after administration influence the potential for an agent to affect radioiodide uptake in the thyroid. Further studies with the rat, preferably hyperthyroid, would be beneficial in generating data to reduce confusing contradictory information on the length and severity of interference of agents in radioiodide thyroid studies.
Yu
Ming-Der
MD
Department of Nuclear Medicine, Tri-Service General Hospital, Taipei, Taiwan.
Shaw
Stanley M
SM
D000818:Animals; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D007472:Iohexol / Q000494:pharmacology*; D008297:Male; D011193:Potassium Iodide / Q000494:pharmacology*; D011441:Propylthiouracil / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*
D007457:Iodine Radioisotopes; D011193:Potassium Iodide; D003974:Diatrizoate Meglumine; D007472:Iohexol; D011441:Propylthiouracil