Investigating the role of natural phyto-oestrogens on bone health in postmenopausal women.
Research on the bone effects of natural phyto-oestrogens after menopause is at a relatively early stage. Published studies are few, difficult to compare and often inconclusive, due in part to design weaknesses. Currently, many questions remain to be answered including to what extent a safe daily intake may prevent postmenopausal bone loss. These questions can only be addressed by conducting well-planned, randomised clinical trials that take into consideration present knowledge in the oestrogen, phyto-oestrogen and bone fields. This review is intended to provide hints for critical decision-making about the selection of subjects, type of intervention, suitable outcome measures and variables that need to be controlled.
Unit of Human Nutrition, National Institute for Research on Food and Nutrition, Via Ardeatina 546, I-00179 Rome, Italy.
Silvia
S
Valtueña
Kevin
K
Cashman
Simon P
SP
Robins
Aedin
A
Cassidy
Alwine
A
Kardinaal
Francesco
F
Branca
D004032:Diet; D004968:Estrogens, Non-Steroidal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007529:Isoflavones; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control*; D048789:Phytoestrogens; D028321:Plant Preparations; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D012107:Research Design; D013025:Glycine max / Q000737:chemistry; D016896:Treatment Outcome
D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations