Muscle relaxants.
Studies on the toxic effects of muscle relaxants are difficult to design because of the need for mechanical ventilation and, consequently, concomitant administration of anaesthetic drugs which may influence the results. The following overview shows that muscle relaxants are weak toxic agents with regard to their teratogenicity, carcinogenicity and cytotoxic effects (including tissue- and organ-damaging effects). Moreover, this chapter presents other side-effects of muscle relaxants under the broad heading of toxicity: the succinylcholine-triggered cytotoxic effects on skeletal muscle cells with different aetiology, for example, or persistent muscle weakness after long-term administration of non-depolarizing muscle relaxants. Receptor stimulation in the central nervous system may cause acute excitement and seizures. Muscle relaxants and their metabolites may interact with muscarinic and nicotinic receptors in other organs and the ganglionic system, for example in the cardiovascular system. Direct stimulation of mast cells, with consequent release of histamine, after administration of muscle relaxants may clinically impose as toxic reactions.
Kampe
Sandra
S
Department of Anesthesiology and Intensive Care Medicine, University of Cologne, Joseph-Stelzmann-Strasse 9, D-50931 Cologne, Germany.
Krombach
Jens W
JW
Diefenbach
Christoph
C
D000014:Abnormalities, Drug-Induced; D000818:Animals; D001921:Brain / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D005333:Fetus / Q000187:drug effects; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D032342:Muscle Cells / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects*
D009466:Neuromuscular Blocking Agents