Attentional resource and processing speed limitations during sentence processing in Parkinson's disease.
Several studies have suggested that patients with Parkinson's disease (PD) have sentence comprehension difficulty in part because of their limited executive resources. However, these assessments confound the executive resources contributing to sentence comprehension with the resources needed for task performance. In the present study, we used a word detection technique that minimizes task demands in order to evaluate attentional and processing speed resources during the comprehension of simple sentences without subordinate clauses and sentences containing subject-relative and object-relative center-embedded subordinate clauses. We found that PD patients have poor sensitivity to phonetic errors embedded in unbound grammatical morphemes, regardless of the clausal structure of the sentence, suggesting difficulty attending to grammatical morphemes. We also found that PD patients are significantly slowed in their sensitivity to phonetic errors in content words embedded in object-relative center-embedded sentences. Slowed sensitivity to content words in object-relative sentences was correlated with timed executive measures of planning. On a traditional measure of comprehension, these PD patients were impaired for sentences containing object-relative center-embedded clauses compared to sentences with subject-relative center-embedded clauses, and comprehension of object-relative sentences was correlated with executive measures. Our findings are consistent with the claim that limited executive resources for strategic attention and processing speed contribute to the sentence comprehension difficulties of PD patients.
Department of Neurology, Hospital of the University of Pennsylvania, 3 Gates Center, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA.
Christine
C
Lee
Murray
M
Grossman
Jennifer
J
Morris
Matthew B
MB
Stern
Howard I
HI
Hurtig
D000368:Aged; D001288:Attention / Q000502:physiology*; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000175:diagnosis* / Q000209:etiology*; D007807:Language Tests; D008037:Linguistics; D008297:Male; D010300:Parkinson Disease / Q000150:complications*; D011930:Reaction Time; D013067:Speech Perception / Q000502:physiology*