A genomewide survey of developmentally relevant genes in Ciona intestinalis. IV. Genes for HMG transcriptional regulators, bZip and GATA/Gli/Zic/Snail.
Many kinds of transcription factors and regulators play key roles in a variety of developmental processes. In the present survey, genes encoding proteins with conserved HMG-box, bZip domains, and some types of zinc finger motifs were surveyed in the completely sequenced genome of Ciona intestinalis. In the present analysis, 21 HMG-box-containing genes and 26 bZip genes were identified as well as four small groups of zinc finger genes in the Ciona genome. The results also showed that a less redundant set of genes is present in the Ciona genome compared with vertebrate genomes. In addition, cDNA clones for almost all genes identified have been cloned and distributed as a " Ciona intestinalis Gene Collection Release I". The present comprehensive analysis therefore provides a means to study the role of these transcription factors in developmental processes of basal chordates.
Yamada
Lixy
L
Department of Zoology, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
Kobayashi
Kenji
K
Degnan
Bernard
B
Satoh
Nori
N
Satou
Yutaka
Y
D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors; D002938:Ciona intestinalis / Q000196:embryology / Q000235:genetics*; D016000:Cluster Analysis; D004268:DNA-Binding Proteins / Q000235:genetics*; D030541:Databases, Genetic; D051790:G-Box Binding Factors; D016678:Genome; D024742:HMG-Box Domains / Q000235:genetics*; D010802:Phylogeny; D014157:Transcription Factors / Q000235:genetics*; D016335:Zinc Fingers / Q000235:genetics*
D050976:Basic-Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; D051790:G-Box Binding Factors; D014157:Transcription Factors