Study and analytical application of ion-pair formation in the system fluoxetine-pyrocatechol violet and fluvoxamine-pyrocatechol violet.
Pyrocatechol violet (PCV) reacts in aqueous media with fluoxetine (FLX) and fluvoxamine (FLV) forming coloured ion-association complexes, which are insoluble in water but quantitatively extracted into chloroform-n-butanol mixture. The composition of the compounds, studied by spectrophotometric methods showed that the molar ratio PCV : FLX and PCV : FLV is 1 : 1. The compounds were characterized by UV-VIS, IR and NMR spectrometry. Under optimal experimental conditions fluoxetine and fluvoxamine were determined in the range 1.3-18.0 microg/ml and 2.6-39.1 microg/ml, respectively. The proposed methods have been succesfully applied to the determination of these drugs in pharmaceuticals and natural samples.
Institute of Chemistry, University of Białystok, Białystok, Poland.
B
B
Starczewska
A
A
Jasińska
B
B
Białous
D000418:Albumins / Q000737:chemistry; D018687:Antidepressive Agents, Second-Generation / Q000032:analysis* / Q000097:blood; D001557:Benzenesulfonates / Q000737:chemistry*; D004396:Coloring Agents; D005473:Fluoxetine / Q000032:analysis* / Q000097:blood; D016666:Fluvoxamine / Q000032:analysis* / Q000097:blood; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D000418:Albumins; D018687:Antidepressive Agents, Second-Generation; D001557:Benzenesulfonates; D004396:Coloring Agents; D007202:Indicators and Reagents; D013607:Tablets; D005473:Fluoxetine; C009134:pyrocatechol violet; D016666:Fluvoxamine