Synthesis of beta-lactamase activated nitric oxide donors.
In order to achieve site specific delivery of NO, we designed conjugates of cephalosporin with NO donors. NO donors such as cupferron and SIN-1 were evaluated as potential choices for conjugates. Cephalosporin conjugated with SIN-1 demonstrated promising beta-lactamase dependent NO releasing ability.
Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Xiaoping
X
Tang
Tingwei
T
Cai
Peng George
PG
Wang
D002511:Cephalosporins / Q000737:chemistry; D008981:Molsidomine / Q000031:analogs & derivatives* / Q000737:chemistry; D020030:Nitric Oxide Donors / Q000138:chemical synthesis* / Q000378:metabolism; D009573:Nitrites / Q000032:analysis / Q000378:metabolism; D009602:Nitrosamines / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis* / Q000378:metabolism; D001618:beta-Lactamases / Q000378:metabolism*
D002511:Cephalosporins; D020030:Nitric Oxide Donors; D009573:Nitrites; D009602:Nitrosamines; D011355:Prodrugs; C002385:linsidomine; D008981:Molsidomine; D001618:beta-Lactamases; C031808:cupferron