[A study on the expression of C-FOS protein after experimental rat brain concussion].
OBJECTIVE
To study the relationship between expression of C-FOS protein and brain concussion and find a sensitive marker of diagnosis of the brain concussion.


METHODS
Fifty-five rats were randomly divided into brain concussion groups and control group. The expression of C-FOS protein was microscopically observed by immunohistochemical method.


RESULTS
There were negative expression of C-FOS protein in control group. In brain concussion group, however, positive expression of C-FOS protein in some neurons was seen at 15 min after brain concussion, and reach to the peak at 6 h after brain concussion, then decreased gradually.


CONCLUSIONS
These findings suggest that detection of C-FOS protein could be an index of diagnosis of brain concussion and a sensitive marker of timing of injury after brain concussion.
Department of Forensic Medicine, Wannan Medical College, Wuhu 241001. wangfeng760914@Sohu.com
Feng
F
Wang
Yong-hong
YH
Li
Yong-liang
YL
Hu
D000818:Animals; D015415:Biomarkers; D001924:Brain Concussion / Q000378:metabolism*; D005260:Female; D005554:Forensic Medicine; D007150:Immunohistochemistry; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D015415:Biomarkers; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger