Application of toxicogenomic analysis to risk assessment of delayed long-term effects of multiple chemicals, including endocrine disruptors in human fetuses.
Our previous studies analyzing umbilical cords show that human fetuses in Japan are exposed to multiple chemicals. Because of these findings, we believe it is necessary to establish a new strategy for examining the possible delayed long-term effects caused by prenatal exposure to multiple chemical combinations and evaluating the health risk to human fetuses. In this commentary we describe our attempts to apply toxicogenomic analysis of umbilical cords, using DNA microarray for future risk assessment. Because the umbilical cord is part of the fetal tissue, it is possible to estimate the effects of chemicals on the fetus by analyzing alteration of the gene expression. This type of toxicogenomic analysis could be a powerful and effective tool for developing a new risk assessment strategy to help investigators understand and possibly prevent long-term effects caused by fetal exposure to multiple chemicals. Worldwide cooperation is needed to establish a new stragegy for risk assessment using toxicogenomic analysis that focuses on the human fetus.
Mori
Chisato
C
Dept. of Bioenvironmental Medicine, Graduate School of Medicine, Chiba University, Chiba, 260-8670 Japan. mori@med.m.chiba-u.ac.jp
Komiyama
Masatoshi
M
Adachi
Tetsuya
T
Sakurai
Kenichi
K
Nishimura
Daisuke
D
Takashima
Kyoka
K
Todaka
Emiko
E
D000818:Animals; D004702:Endocrine Glands / Q000187:drug effects*; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006801:Humans; D010597:Pharmacogenetics / Q000941:ethics / Q000379:methods; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D018570:Risk Assessment; D014470:Umbilical Cord / Q000187:drug effects
D004785:Environmental Pollutants