Orlistat in the treatment of NASH: a case series.
Nonalcoholic steatohepatitis is now recognized as a common chronic liver disorder. Up to 16% of affected patients may progress to cirrhosis. The incidence and prevalence of this disease are noted to be increasing, in parallel with the nationwide increase in obesity and diabetes. Treatment options for these patients remain quite limited, however. Weight reduction has been advocated, but there are little data to support this practice, as most patients are unable to comply with the proper dietary modifications. We report three obese patients with biopsy-proven nonalcoholic steatohepatitis treated for 6-12 months with a weight reduction medication, orlistat, who lost between 22-42 lb, and had significant clinical and histopathological improvement on follow-up.
Saint Louis University Liver Center, Division of Gastroenterology and Hepatology, St. Louis, Missouri 63110, USA.
Stephen A
SA
Harrison
Sanjay
S
Ramrakhiani
Elizabeth M
EM
Brunt
Maan A
MA
Anbari
Cherise
C
Cortese
Bruce R
BR
Bacon
D000328:Adult; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D005234:Fatty Liver / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D005260:Female; D006505:Hepatitis / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007783:Lactones / Q000627:therapeutic use*; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D000077403:Orlistat
D019440:Anti-Obesity Agents; D007783:Lactones; D000077403:Orlistat