Inhibitors of farnesyltransferase: 5-arylacryloylaminobenzophenones show antimalarial activity.
Wiesner
J
J
Department für Pharmazie, Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Germany.
Ortmann
R
R
Mitsch
A
A
Wissner
P
P
Sattler
I
I
Jomaa
H
H
Schlitzer
M
M
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D001577:Benzophenones / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D051231:Farnesyltranstransferase; D010963:Plasmodium falciparum / Q000187:drug effects; D013329:Structure-Activity Relationship
D000962:Antimalarials; D001577:Benzophenones; D004791:Enzyme Inhibitors; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase