Mouse models with modified p53 sequences to study cancer and ageing.
Experiments with p53 transgenic and p53 gene-targeted mouse strains have substantiated, and in some cases challenged, a number of hypotheses on the biology of the p53 protein. New questions have emerged regarding similarities and differences between murine and human genetic networks in various tissues. Mouse models with targeted p53 alleles are now applied not only to investigate tumour susceptibility, but also to address questions pertinent to molecular epidemiology, chemoprevention, development of anticancer p53-specific pharmaceuticals, and ageing.
Clarke
A R
AR
1Cardiff School of Biosciences, Cardiff University, Cardiff, UK. clarkeAR@cardiff.ac.uk
Hollstein
M
M
D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D018390:Gene Targeting / Q000379:methods / Q000639:trends; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
D016159:Tumor Suppressor Protein p53