[Improvements of lentiviral vector and its application in gene therapy of hematological diseases].
As lentiviral vector holds the characteristics of higher transfection to non-dividing cells, larger capacity of transfer gene fragments, long-term expression of therapeutic gene and lower rate of immunological response, therefore it becomes potential viral vector in gene therapy. Improvements of lentiviral vector, human immunodeficiency virus type-I as example, and its application in gene transfer for gene therapy of hematological diseases are emphasized in this review.
Zhu
Hong-Hu
HH
Department of Hematology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China.
Xu
Kai-Lin
KL
D005199:Fanconi Anemia / Q000628:therapy; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics; D006402:Hematologic Diseases / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006467:Hemophilia A / Q000628:therapy; D006801:Humans; D016086:Lentivirus / Q000235:genetics*; D007938:Leukemia / Q000628:therapy; D017086:beta-Thalassemia / Q000628:therapy