Histiocytic sarcoma in C57BL/6J female mice is associated with liver hematopoiesis: review of 41 cases.
Forty-one cases of histiocytic sarcoma (HS) in C57BL/6J mice were histopathologically studied with special regard to unexpected associated hematopoietic disorders. These cases were retrieved among C57BL/6J female mice used as control mice in a chronic low-dose irradiation experiment. Hematopoietic characteristics were analysed by comparison to 41 disease-free mice from the same cohort. Tumoral involvement of the liver was observed in all 41 HS-bearing mice, followed by infiltration of the spleen (61.8%), lung (32.4%), bone marrow (14.3%), uterus (12.2%), lymph node (9.8%), and kidney (2.4%). By comparative analysis, we were able to demonstrate a significant association of HS with liver hematopoiesis (89.5% in HS group vs 15% in control mice, p < 0.00001), and with central hematopoietic disorders involving the myelocytic cells (decreased in HS, p = 0.003) and erythrocytic cells (increased in HS, p = 0.001). Microscopic characteristics of these 41 cases and physiopathology of the newly described hematopoietic features in HS are further discussed.
Laboratoire d'Histologie-Embryologie, Faculté de Médecine Toulouse-Rangueil, 31062 Toulouse, France.
Magali
M
Lacroix-Triki
Laetitia
L
Lacoste-Collin
Suzanne
S
Jozan
Jean-Paul
JP
Charlet
Claude
C
Caratero
Monique
M
Courtade
D000818:Animals; D001853:Bone Marrow / Q000473:pathology / Q000502:physiology; D001854:Bone Marrow Cells; D002452:Cell Count; D035061:Control Groups; D005260:Female; D006411:Hematopoiesis, Extramedullary; D008099:Liver / Q000473:pathology* / Q000502:physiology; D008168:Lung / Q000473:pathology / Q000502:physiology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology / Q000473:pathology* / Q000662:veterinary; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000473:pathology / Q000502:physiology