Antidiarrhoeal activity of hot water extract of black tea (Camellia sinensis).
The effect of a hot water extract of black tea (Camellia sinensis (L.) O. Kuntze, Theaceae) on upper gastrointestinal transit and on diarrhoea was investigated employing conventional rodent models of diarrhoea. Black tea extract was found to possess antidiarrhoeal activity in all the models of diarrhoea used. Naloxone (0.5 mg/kg i.p.) significantly inhibited the antidiarrhoeal activity of the extract as well as loperamide, thus indicating a role of the opioid system in the antidiarrhoeal activity of the extract.
Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Calcutta 700032, India.
S E
SE
Besra
A
A
Gomes
D K
DK
Ganguly
J R
JR
Vedasiromoni
D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002368:Castor Oil; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008139:Loperamide / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009270:Naloxone / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013662:Tea
D000930:Antidiarrheals; D010936:Plant Extracts; D013662:Tea; D009270:Naloxone; D008139:Loperamide; D002368:Castor Oil