[Changes of pulmonary surfactant in the rat lung exposed to terephthalic acid].
The contents of phospholipids in the lung surfactant in bronchoalveolar lavage fluid(BALF) of rats inhaled terephthalic acid (TPA) dust were analysed with high pressure liquid chromatography (HPLC). The average geometric concentrations of TPA dust in experimental groups were 8.93, 274.45 and 618.12 mg/m3 respectively. The results showed that phosphatidylcholine(PC), phosphatidyl glycerol(PG), and phosphatidylinositol(PI) of the rats exposed to TPA at the middle and high concentrations were decreased as compared with those in the control (P < 0.001). It was suggested that the functions of producing and secreting pulmonary surfactant in type II epithelial cells were damaged after inhalating TPA dust.
Shi
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Prevention & Health Center of Yizheng Chemical Fibre Group Corporetion, Yizheng 211900, China.
Wang
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D
Wang
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Xu
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D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004391:Dust; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D008168:Lung / Q000378:metabolism*; D008297:Male; D010795:Phthalic Acids / Q000633:toxicity*; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004391:Dust; D010795:Phthalic Acids; D011663:Pulmonary Surfactants; C011363:terephthalic acid