Familial invasive and borderline ovarian tumors by proband status, age and histology.
Age-specific familial risks in ovarian cancer have not been assessed by histologic types of medically verified cancers. We used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and 19,175 invasive and 3,436 borderline ovarian cancers to calculate, by affected family members, standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for familial ovarian cancer in 0-66 year old daughters. SIRs for all invasive ovarian cancer were 2.68 (95% CI 2.22-3.21) by ovarian cancer in mother, 2.94 (1.40-5.94) by an affected sister and 24.03 (6.12-74.46) by both an affected mother and sister. The population-attributable fraction from mothers was 2.52%. Seropapillary cystadenocarcinoma showed the highest familial risk, but the effect of histopathol subtype could not be fully assessed because of lack of data in probands. Age-specific data showed some early-onset components and an unusual maximal incidence in the 40s. A comparison to an earlier study on BRCA1/2 mutation analysis and relative risks of ovarian and breast cancer suggests that these mutations could account for 26% of the familial aggregation of ovarian cancer. Histopathology and age of onset appear to be important attributes of familial ovarian cancer, suggesting that further gene identification efforts should target a specific histopathology in early-onset patients.
Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden. kari.hemminki@cnt.ki.se
Kari
K
Hemminki
Charlotta
C
Granström
D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics; D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001943:Breast Neoplasms / Q000453:epidemiology; D018269:Carcinoma, Endometrioid / Q000453:epidemiology / Q000235:genetics; D018283:Cystadenocarcinoma, Papillary / Q000453:epidemiology / Q000235:genetics; D018284:Cystadenocarcinoma, Serous / Q000453:epidemiology / Q000235:genetics; D005260:Female; D018237:Germinoma / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D009035:Mothers; D009361:Neoplasm Invasiveness; D009386:Neoplastic Syndromes, Hereditary / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D012306:Risk; D018312:Sex Cord-Gonadal Stromal Tumors / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D035781:Siblings; D013548:Sweden / Q000453:epidemiology