Circulating levels of FAS/APO-1 in patients with the systemic inflammatory response syndrome.
Resolution of inflammation/infection involves removal of neutrophils and other inflammatory cells by the induction of apoptosis. Fas/Apo-1 is a widely occurring apoptotic signal receptor molecule expressed by almost any type of cell, which is also released in a soluble circulating form. In this study we investigated the role of circulating Fas/Apo-1 in patients with systemic inflammatory response syndrome (SIRS). We evaluated 57 critically ill patients, 34 with infectious SIRS (sepsis and septic shock), and 23 patients with noninfectious SIRS. Circulating Fas/Apo-1 was determined by a commercially available immunoassay. Our results clearly show that levels of Fas/Apo-1 were significantly elevated in patients with infectious and noninfectious SIRS (10.4 +/- 8.1 pg/mL, controls: 5.0 +/- 0.7 pg/mL; p < 0.0001). In addition, Fas/Apo-1 levels were not able in predicting in predicting poor outcome of patients with SIRS. In conclusion, these results show that increased levels of Fas/Apo-1 from patients with SIRS is a mechanism which contribute to inflammatory response through accumulation of neutrophils at sites of inflammation/infection.
Section of Pediatric Infectious Diseases, Regional Hospital, Varese, Italy. donatotorre@libero.it
Donato
D
Torre
Roberto
R
Tambini
Mariangela
M
Manfredi
Valerio
V
Mangani
Paola
P
Livi
Viviana
V
Maldifassi
Paolo
P
Campi
Filippo
F
Speranza
D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016638:Critical Illness / Q000401:mortality*; D053222:Fas Ligand Protein; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood* / Q000503:physiopathology; D011336:Probability; D011379:Prognosis; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012772:Shock, Septic / Q000097:blood / Q000175:diagnosis; D015996:Survival Rate; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood* / Q000175:diagnosis*; D019014:fas Receptor / Q000097:blood*
D015415:Biomarkers; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor