Uniform response criteria in Waldenstrom's macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom's Macroglobulinemia.
Waldenstrom's macroglobulinemia (WM) is a malignant disorder of lymphoplasmacytic cells that produce a monoclonal immunoglobulin M (IgM). Since the original description by Jan Waldenström of three patients with symptoms of hyperviscosity due to circulating monoclonal IgM, the definition of WM has been controversial. Standardized criteria for diagnosis have now been proposed, including the presence of any IgM monoclonal protein and marrow and/or nodal lymphoplasmacytic cells. Although previous response criteria have generally incorporated parameters for monoclonal protein reduction and/or improvement of marrow/nodal involvement, specific and uniform response criteria are needed to facilitate comparisons of response, remission duration, progression-free survival, and overall survival in clinical trials similar to those previously established for other diseases such as chronic lymphocytic leukemia, lymphoma, and myeloma. This is of particular importance as new agents are developed and evaluated. This presentation represents consensus recommendations for uniform response criteria for use in assessing responses to treatment for patients with WM, which were prepared in conjunction with the Second International Workshop held in Athens, Greece during September 2002.
University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.
Donna
D
Weber
Steven P
SP
Treon
Christos
C
Emmanouilides
Andrew R
AR
Branagan
John C
JC
Byrd
Joan
J
Bladé
Eva
E
Kimby
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001536:Bence Jones Protein / Q000652:urine; D017281:Cost of Illness; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism; D008206:Lymphatic Diseases; D008279:Magnetic Resonance Imaging; D017410:Practice Guidelines as Topic; D012008:Recurrence; D012074:Remission Induction; D013163:Splenomegaly; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed; D008258:Waldenstrom Macroglobulinemia / Q000097:blood / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*
D000970:Antineoplastic Agents; D007075:Immunoglobulin M; D001536:Bence Jones Protein