Who's on first in the cellular response to DNA damage?
Cellular DNA-repair pathways involve proteins that have roles in other DNA-metabolic processes, as well as those that are dedicated to damage removal. Several proteins, which have diverse functions and are not known to have roles in DNA repair, also associate with damaged DNA. These newly discovered interactions could either facilitate or hinder the recognition of DNA damage, and so they could have important effects on DNA repair and genetic integrity. The outcome for the cell, and ultimately for the organism, might depend on which proteins arrive first at sites of DNA damage.
Cline
Susan D
SD
Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, California 94305-5020, USA.
Hanawalt
Philip C
PC
D000818:Animals; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004249:DNA Damage; D011088:DNA Ligases / Q000378:metabolism; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D008957:Models, Genetic; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D004247:DNA; D011088:DNA Ligases