[The study of autowave mechanisms of electrocardiogram variability during high frequency arrhythmias: mathematical modeling data].
High-frequency cardiac arrhythmias are very dangerous, as they quite often lead to sudden death. These high-frequency arrhythmias are frequently produced by rotating autowaves. In the given work, the dynamics of a rotating three-dimensional excitation scroll wave and the influence of this dynamics on the variability of model electrocardiograms (ECGs) were simulated with the use of the Aliev--Panfilov model for both homogeneous and heterogeneous excitable media. Model ECGs were obtained by summing up local membrane potentials, while ECG variability was estimated numerically through the normalized variability analysis. In the homogeneous medium, the stability of the scroll wave to its filament perturbations was shown to be dependent both on the excitability of the medium and tension of the filament, while in the heterogeneous medium, the scroll was shown to be unstable. It was shown that the scroll wave dynamics affects essentially the variability of the model ECGs, and the ECG variability increases as the excitation threshold value grows. It was found that, at some parameters of the excitable medium, the variability of ECGs in the homogeneous medium is higher than in the heterogeneous medium.
Medvinskiĭ
A B
AB
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290 Russia. medvinsky@iteb.ru
Rusakov
A V
AV
Moskalenko
A V
AV
Fedorov
M V
MV
Panfilov
A V
AV
D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D004562:Electrocardiography; D008955:Models, Cardiovascular