Nuclear receptors orchestrate detoxification pathways.
Two nuclear receptors of xenobiotic drugs, PXR and CAR, are central regulators of detoxification enzymes. New studies extend the role of these receptors to a natural detoxification process. They coordinate induction of proteins for storage, glucuronidation, and canalicular transport of bilirubin.
Roy-Chowdhury
Jayanta
J
Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Locker
Joseph
J
Roy-Chowdhury
Namita
N
D000818:Animals; D001663:Bilirubin / Q000378:metabolism; D000090702:Constitutive Androstane Receptor; D014453:Glucuronosyltransferase / Q000378:metabolism; D006801:Humans; D008658:Inactivation, Metabolic; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D000099148:UGT1A1 Enzyme
D001663:Bilirubin; D000090702:Constitutive Androstane Receptor; D014453:Glucuronosyltransferase; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D014157:Transcription Factors; D000099148:UGT1A1 Enzyme