Toxicological aspects of Kampo medicines in clinical use.
Among 210 medicinal prescriptions used in present-day Japan, the clinical uses and the acute, chronic and mutagenic toxicity study of 16 Kampo (Japanese herbal) medicines are summarized. These Kampo medicines are classified into two categories; eight prescriptions containing Bupleurum root (Bupleurum falcatum L.) such as Sho-saiko-to and Saiko-keishi-to, and eight prescriptions not containing Bupleurum root such as Juzen-taiho-to and Ninjin-yoei-to. Studies of some potential interaction between herbal medicine and western drugs are also described.
Ikegami
Fumio
F
Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan. ikegami@p.chiba-u.ac.jp
Fujii
Yuichi
Y
Ishihara
Kazuhisa
K
Satoh
Tetsuo
T
D000818:Animals; D029972:Bupleurum / Q000737:chemistry / Q000633:toxicity; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use / Q000633:toxicity*; D006801:Humans; D007564:Japan; D020835:Medicine, Kampo; D018675:Toxicity Tests
D004365:Drugs, Chinese Herbal; C063587:juzentaihoto; C072867:ren-shen-yang-rong-tang