Primary cutaneous diffuse large B cell lymphoma: a clinically aggressive case.
An 80-year-old woman was diagnosed with primary cutaneous B cell lymphoma. She had multifocal cutaneous tumors, but no nodal lymphadenopathy or bone marrow involvement. Histopathological examination of a biopsy specimen showed diffuse large B cell lymphoma without a bcl-2 expression. Complete resolution of hypercalcemia and disappearance of tumors were achieved with CHOP therapy, but a rapidly progressive skin lesion was observed soon after the completion of the therapy. The clinical manifestation of primary cutaneous diffuse large B cell lymphoma is diverse and the treatment strategy is not entirely clarified. This case represents another example of this rare lymphoma.
Department of Hematology and Oncology, JA Aichi Showa Hospital Aichi.
Hiroto
H
Narimatsu
Yoshihisa
Y
Morishita
Kazuyuki
K
Shimada
Kazutaka
K
Ozeki
Akio
A
Kohno
Yukio
Y
Kato
Tetsuro
T
Nagasaka
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*
D019253:Proto-Oncogene Proteins c-bcl-2