Hormonal basis of mood and postpartum disorders.
Mood disorders during the postpartum period occur in 10% to 15% of women. The hormonal basis of these disorders, however, has not been investigated systematically and extensively. We review recent studies, primarily from the past 5 years, in which investigators examined the major categories of proposed hormonal etiologies, including gonadal steroids, thyroid hormones, cortisol, prolactin, and melatonin, and then present descriptive statistics of our preliminary findings in these hormonal dimensions from a group of 20 depressed and normal control pregnant and postpartum women.
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0804, USA. bparry@ucsd.edu
Barbara L
BL
Parry
Diane L
DL
Sorenson
Charles J
CJ
Meliska
Neal
N
Basavaraj
Gina G
GG
Zirpoli
Anthony
A
Gamst
Richard
R
Hauger
D000328:Adult; D016022:Case-Control Studies; D019052:Depression, Postpartum / Q000097:blood* / Q000523:psychology; D004967:Estrogens / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008550:Melatonin / Q000097:blood; D019964:Mood Disorders / Q000097:blood* / Q000209:etiology; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood; D013997:Time Factors
D004967:Estrogens; D006728:Hormones; D013963:Thyroid Hormones; D011374:Progesterone; D011388:Prolactin; D008550:Melatonin; D006854:Hydrocortisone