[Acute coronary thrombosis].
Atherosclerosis is an inflammatory disease of the arterial wall. Ischaemic manifestations of atherosclerosis are mainly due to thrombus formation upon a superficially eroded (denudation of luminal endothelium, 40% of cases) or deeply ruptured (fibrous cap rupture, 60% of cases) plaques. Recent studies have unraveled potentially critical roles for both inflammatory and apoptotic processes in plaque unstability leading to thrombus formation. Pro-inflammatory mediators have been particularly implicated in the loss of smooth muscle cells and the promotion of collagen degradation that are responsible for fibrous cap rupture, whereas apoptosis has been identified as one of the major determinants of plaque thrombogenicity.
INSERM U 541 Hôpital Lariboisière 75475 Paris. ziad.mallat@larib.inserm.fr
Alain
A
Tedgui
Ziad
Z
Mallat
D000208:Acute Disease; D017209:Apoptosis; D001161:Arteriosclerosis / Q000150:complications*; D003094:Collagen / Q000378:metabolism; D003328:Coronary Thrombosis / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation; D009130:Muscle, Smooth / Q000473:pathology
D003094:Collagen