Dexamethasone differentially inhibits thyroxine- or growth hormone-induced body and organ growth of Snell dwarf mice.
Supraphysiological doses of glucocorticoids cause growth retardation in both animals and humans. Many studies have addressed the interaction of glucocorticoids with the GH/IGF system, but little is known about the effect of glucocorticoids on T(4)-stimulated growth. The Snell dwarf mouse is deficient in GH, thyroid-stimulating hormone, and prolactin and therefore allows the study of the effect of glucocorticoids on the growth induced by GH and T(4) without their mutual interaction. Four weeks of treatment with T(4) (1 micro g/d) or human GH (50 mU/d) equally increased nose-tail length (3.1 +/- 0.1 cm and 3.0 +/- 0.2 cm, respectively). Dexamethasone (DXM) had much less impact on T(4)-stimulated growth than on GH-induced growth (T(4) + DXM: 2.4 +/- 0.1 cm vs. GH+ DXM: 1.4 +/- 0.1 cm). Similar data were obtained for body weight gain. T4 and GH had a different effect on the weight of various organs: GH caused a higher increase in liver and lumbar vertebrae weight, and T(4) was a better stimulator for kidney (P < 0.05), thymus, and spleen growth. Remarkably, T(4)-stimulated growth of the organs was less affected by DXM than GH-induced organ growth. GH even potentiated the growth inhibition by DXM in the thymus and tibia. In conclusion, T(4)-stimulated growth in Snell dwarf mice is less affected by DXM than growth stimulated by GH
Department of Pediatric Endocrinology, University Medical Center, 3508 AB Utrecht, The Netherlands. raoul.rooman@uza.be
Raoul P A
RP
Rooman
Gilliam
G
Kuijpers
Ria
R
Gresnigt
Ruud
R
Bloemen
Johanna G
JG
Koster
Sylvia C
SC
van Buul-Offers
D000818:Animals; D001824:Body Constitution; D001835:Body Weight / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology*; D004195:Disease Models, Animal; D004347:Drug Interactions; D004392:Dwarfism / Q000188:drug therapy / Q000503:physiopathology*; D005938:Glucocorticoids / Q000494:pharmacology*; D013006:Growth Hormone / Q000494:pharmacology*; D007668:Kidney / Q000033:anatomy & histology / Q000254:growth & development; D008099:Liver / Q000033:anatomy & histology / Q000254:growth & development; D008159:Lumbar Vertebrae / Q000254:growth & development; D051379:Mice; D008817:Mice, Mutant Strains; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000033:anatomy & histology / Q000254:growth & development; D013950:Thymus Gland / Q000033:anatomy & histology / Q000254:growth & development; D013974:Thyroxine / Q000494:pharmacology*; D013977:Tibia / Q000254:growth & development
D005938:Glucocorticoids; D003907:Dexamethasone; D013006:Growth Hormone; D013974:Thyroxine