Discontinuation of antidepressants in newly admitted psychotic patients.
Antidepressants may exacerbate manic or psychotic symptoms in vulnerable individuals. The authors discontinued antidepressants in 16 consecutive cases in which patients with manic or psychotic symptoms were otherwise judged to be on a satisfactory regimen prior to admission. Thirteen of the patients improved rapidly, which suggests a possible association between antidepressant discontinuation and clinical improvement in this patient group.
Department of Psychiatry, Yale University School of Medicine, 25 Park Street, New Haven, CT 06515, USA.
Malcolm B
MB
Bowers
Bernice G
BG
McKay
Carolyn M
CM
Mazure
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000209:etiology*; D010054:Brief Psychiatric Rating Scale / Q000706:statistics & numerical data; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000150:complications / Q000188:drug therapy / Q000209:etiology*; D012559:Schizophrenia / Q000209:etiology; D013223:Statistics as Topic
D000928:Antidepressive Agents