Do current sequence analysis algorithms disclose multifunctional (moonlighting) proteins?
A number of multifunctional, 'moonlighting', proteins have been analyzed by different current programs to test whether they identify both functions. PSI-BLAST and PRODOM perform best in predicting the alternative function.
Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona. 08193 Bellaterra, Spain. enric.querol@uab.es
Antonio
A
Gómez
Nuria
N
Domedel
Juan
J
Cedano
Jaume
J
Piñol
Enrique
E
Querol
D000465:Algorithms; D030562:Databases, Protein; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000145:classification*; D040901:Proteomics / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D013329:Structure-Activity Relationship
D011506:Proteins