Molecular features of the cytolytic pore-forming bacterial protein toxins.
The repertoire of the cytolytic pore-forming protein toxins (PFT) comprises 81 identified members. The essential feature of these cytolysins is their capacity to provoke the formation of hydrophilic pores in the cytoplasmic membranes of target eukaryotic cells. This process results from the binding of the proteins on the cell surface, followed by their oligomerization which leads to the insertion of the oligomers into the membrane and formation of protein-lined channels. It impairs the osmotic balance of the cell and causes cytolysis. In this review the molecular aspects of a number of important PFT and their respective encoding structural genes will be briefly described.
Institut Pasteur, 75 015 Paris, France. joseph.alouf@wanadoo.fr
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Alouf
D000818:Animals; D001419:Bacteria / Q000378:metabolism / Q000472:pathogenicity; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D001427:Bacterial Toxins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D003603:Cytotoxins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D018272:Porins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D003603:Cytotoxins; D018272:Porins