Glycosmis arborea extract as a hepatoprotective agent.
Glycosmis arborea is a plant possessing various medicinal properties. The aim of the present study was to investigate the hepatoprotective efficacy of the butanol extract obtained from the aerial parts of the plant. The test sample was prepared by extracting the material through different steps. The extract thus obtained was dissolved in normal saline. Albino rats were prophylactically treated with the extract (i.p.) for 3 weeks. At the end of 3rd week all the groups were injected with hepatotoxic agents. After 48 h of injection, blood was collected and livers were taken out. Different enzymes in the serum were assayed and histopathological study was performed with liver. Glycosmis arborea extract was able to overcome the toxic effects of hepatotoxic agents in terms of lowering the levels of serum GPT, alkaline phosphatase and increased level of SOD in serum. TBARS generation in liver was also altered. Moreover, necrosis of liver produced by carbon tetrachloride was reversed by the extract.
Gomes
A
A
Drug Development Division, Indian Institute of Chemical Biology, Calcutta, India.
Das
M
M
Sur
P
P
Besra
S E
SE
Chakravorty
A K
AK
Das
B
B
Ganguly
D K
DK
Vedasiromoni
J R
JR
D000082:Acetaminophen / Q000633:toxicity; D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects; D000469:Alkaline Phosphatase / Q000097:blood / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury; D005688:Galactosamine / Q000633:toxicity; D007928:Lethal Dose 50; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000517:prevention & control; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027821:Rutaceae; D013482:Superoxide Dismutase / Q000097:blood / Q000187:drug effects; D015996:Survival Rate; D023382:Toxicity Tests, Acute
D010936:Plant Extracts; D000082:Acetaminophen; D005688:Galactosamine; D002251:Carbon Tetrachloride; D013482:Superoxide Dismutase; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase