Association of hepatitis C infection and antiretroviral use with diabetes mellitus in drug users.
We performed a cross-sectional analysis of factors associated with diabetes mellitus among 557 drug users who were recruited from a methadone treatment program and were participating in a longitudinal study of hepatitis C virus (HCV) infection. We found that HCV infection was strongly associated with diabetes mellitus (adjusted odds ratio [OR], 2.9; 95% confidence interval [CI], 1.3-6.4) after controlling for age, race, unemployment, and body mass index. Among HIV-infected drug users, receipt of antiretroviral therapy (ART) for >1 year was also associated with diabetes (adjusted OR for receipt of ART without a protease inhibitor, 4.1 [95% CI, 1.1-15.5]; adjusted OR for receipt of ART including a protease inhibitor, 5.5 [95% CI, 1.5-20.4]).
AIDS Research Program, Department of Epidemiology and Social Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467, USA. ahoward@montefiore.org
Andrea A
AA
Howard
Robert S
RS
Klein
Ellie E
EE
Schoenbaum
D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D048909:Diabetes Complications; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D016174:Hepacivirus; D006526:Hepatitis C / Q000209:etiology*; D018937:Hepatitis C Antibodies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015819:Substance Abuse, Intravenous / Q000150:complications*
D019380:Anti-HIV Agents; D018937:Hepatitis C Antibodies