[Regulation of a new amino acids preparation on the expression of growth factors in traumatized rats].
The effect of a new amino acids formulas on wound healing and the expression of several growth factors in traumatized rats were investigated. Twenty-four male Wistar rats were randomly divided into control group, 17AA group and 20AA group after operation, and fed with rations containing tyrosine, a commercial amino acids (17AA), and a new amino acids formula(20AA) respectively. Body weight, dietary intake, the hydroyproline and tensile strength of wound were measured. At the same time, the expression of EGF, TGF beta 1 and bFGF in small intestine were also determined. The results showed that the levels of hydroyproline in sponge and tensile-strength of wound were higher in 20AA group than in 17AA group(P < 0.05). The orders of expression of EGF, TGF beta 1 and bFGF in small intestine were as follows: 20AA group > 17AA group > control group. It is concluded that the new amino acids preparations can enhance the expression of growth factors in small intestines and promote wound healing.
Jiang
Yugang
Y
Institute of Hygiene and Environmental Medicine, Tianjin 300050, China.
Guo
Changjiang
C
Yang
Jijun
J
Wei
Jingyu
J
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D016228:Endothelial Growth Factors / Q000096:biosynthesis* / Q000235:genetics; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis* / Q000235:genetics; D007421:Intestine, Small / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D016212:Transforming Growth Factor beta / Q000096:biosynthesis / Q000235:genetics; D053773:Transforming Growth Factor beta1; D014945:Wound Healing / Q000187:drug effects; D014947:Wounds and Injuries / Q000097:blood*
D000596:Amino Acids; D016228:Endothelial Growth Factors; D012333:RNA, Messenger; C508962:Tgfb1 protein, rat; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D016222:Fibroblast Growth Factor 2