Preliminary evaluation of inhibition of matrix-metalloprotease MMP-2 and MMP-9 by Passiflora edulis and P foetida aqueous extracts.
Fruit's decoctions of Passiflora edulis and P. foetida var. albiflora were evaluated for the inhibition of activity of gelatinase MMP-2 and MMP-9, two metallo-proteases involved in the tumour invasion, metastasis and angiogenesis. Both water extracts, at different concentrations, inhibited the enzymes.
Dipartimento di Biologia, V le G Colombo 3, Padova 35131, Italy.
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Puricelli
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Dell'Aica
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Sartor
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S
Garbisa
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Caniato
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005638:Fruit; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D029598:Passiflora; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D019714:Tissue Inhibitor of Metalloproteinases / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D061965:Matrix Metalloproteinase Inhibitors; D010936:Plant Extracts; D019714:Tissue Inhibitor of Metalloproteinases