Intrauterine pathology in women with abnormal uterine bleeding taking hormone replacement therapy.
OBJECTIVE
To assess the frequency of intrauterine pathology among women with abnormal uterine bleeding (AUB) while taking hormone replacement therapy (HRT), and correlate pathology with clinical features.


METHODS
Retrospective review (Canadian Task Force classification II-2).


METHODS
University teaching hospital-based outpatient clinic.


METHODS
Ninety-nine women.


METHODS
Observational evaluation.


RESULTS
Intrauterine pathology was found in 16 (18.6%) of 99 women with AUB. The frequency was 4 times higher in those with AUB after achieving amenorrhea with a continuous combined regimen of HRT than in those with AUB with only 6 months of HRT. It was also higher in patients taking a continuous combined regimen in whom AUB lasted for more than 6 months.


CONCLUSIONS
Hysteroscopic examination with endometrial sampling is recommended if AUB continues after the first 6 months of HRT or if it occurs after a period of amenorrhea.
Leung
Pui Ling
PL
Department of Obstetrics and Gynaecology, Prince of Wales Hospital, Chinese University of Hong Kong.
Tam
Wing Hung
WH
Kong
Wing Shan
WS
Yuen
Pong Mo
PM
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D015331:Cohort Studies; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D020249:Hormone Replacement Therapy / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D015907:Hysteroscopy / Q000379:methods*; D007150:Immunohistochemistry; D008595:Menorrhagia / Q000453:epidemiology / Q000473:pathology; D008875:Middle Aged; D011446:Prospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D014592:Uterine Hemorrhage / Q000453:epidemiology / Q000473:pathology*