mRNA expression of the lipid and mechano-gated 2P domain K+ channels during rat brain development.
mRNAs encoded by genes for the lipid-sensitive mechano-gated K(+) channels TREK-1, TREK-2, and TRAAK were detected in rat brain at different life-cycle stages: 18-day embryos, postnatal days 1, 7, 28, and 60 (adulthood). mRNA expression of TREK-1 or TREK-2 showed no appreciable changes during the development of cortex and hippocampus. TRAAK mRNA expression increased with development and reached an apparent maximum at postnatal day 28 in hippocampus and day 60 in cortex. These data suggest that TRAAK might be important in the development of rat brain.
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Xiannongtan St., Beijing 100050, China.
Xianghua
X
Xu
Yaping
Y
Pan
Xiaoliang
X
Wang
D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D005314:Embryonic and Fetal Development; D005231:Fatty Acids, Unsaturated / Q000502:physiology; D015870:Gene Expression; D015640:Ion Channel Gating / Q000502:physiology*; D015221:Potassium Channels / Q000096:biosynthesis* / Q000235:genetics; D024683:Potassium Channels, Tandem Pore Domain; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013314:Stress, Mechanical
D005231:Fatty Acids, Unsaturated; C503444:Kcnk10 protein, rat; C503434:Kcnk4 protein, rat; D015221:Potassium Channels; D024683:Potassium Channels, Tandem Pore Domain; D012333:RNA, Messenger; C103742:potassium channel protein TREK-1