Keratitis caused by Scedosporium apiospermum successfully treated with a cornea transplant and voriconazole.
A case of Scedosporium apiospermum keratitis was successfully treated with oral voriconazole and penetrating keratoplasty. Voriconazole levels in the aqueous humor were 53% of the levels in plasma and exceeded the MIC for the isolate by sevenfold.
Nulens
Eric
E
Department of Medical Microbiology, University Medical Center Nijmegen and Nijmegen University Center for Infectious Diseases, The Netherlands. e.nulens@mmb.umcn.nl
Eggink
Cathrien
C
Rijs
Antonius J M M
AJ
Wesseling
Pieter
P
Verweij
Paul E
PE
D000935:Antifungal Agents / Q000627:therapeutic use*; D001203:Ascomycota / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity*; D016039:Corneal Transplantation; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000382:microbiology* / Q000601:surgery; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole