Clinical application of direct sputum sensitivity testing in a severe infective exacerbation of cystic fibrosis.
A 16-year-old male with cystic fibrosis (CF) was admitted to hospital with a severe infective exacerbation. Despite standard management, including conventionally selected intravenous antibiotics for Pseudomonas aeruginosa, chest physiotherapy, and institution of noninvasive ventilation (NIV) for progressive hypercapneic respiratory failure, he continued to deteriorate. Direct sputum sensitivity testing (DSST) revealed a novel combination of antibiotics that resulted in a rapid and remarkable clinical improvement. DSST is a form of "whole" sputum sensitivity testing that provides information on antibiotic synergy, and may more accurately reflect in vivo antibiotic sensitivity patterns in cystic fibrosis.
Adult Cystic Fibrosis Unit, Southampton University Hospital NHS Trust, Southampton, Hampshire, UK. dserisier@hotmail.com
David J
DJ
Serisier
Graeme
G
Jones
Andrew
A
Tuck
Gary
G
Connett
Mary P
MP
Carroll
D000293:Adolescent; D003550:Cystic Fibrosis / Q000150:complications* / Q000188:drug therapy* / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests / Q000379:methods*; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012138:Respiratory Therapy; D013183:Sputum / Q000382:microbiology