Klinefelter syndrome (39 XXY) in an adult Siberian tiger (Panthera tigris altaica).
Fibroblast cultures of a skin biopsy from an adult intact male Siberian tiger (Panthera tigris altaica) revealed an abnormal standard and G-banded karyotype diploid chromosome number of 2n = 39 XXY due to an extra sex chromosome as opposed to the expected 2n = 38 XY. The tiger was euthanatized 1 yr later due to acute multifocal intervertebral disc disease. Histopathology of the reproductive tract demonstrated a paucity of seminiferous tubules and these were devoid of spermatagonia. An increase in fibrous connective tissue was noted in sections of the prostate and epididymis, and expansion of the fibrous interstitium was observed in the testes.
Kansas City Zoo, 6800 Zoo Drive, Kansas City, Missouri 64132, USA.
Wm Kirk
WK
Suedmeyer
Marlys L
ML
Houck
John
J
Kreeger
D000818:Animals; D000836:Animals, Zoo; D002335:Carnivora; D002843:Chromatin / Q000473:pathology; D002871:Chromosome Banding / Q000662:veterinary; D004822:Epididymis / Q000473:pathology; D017809:Fatal Outcome; D005347:Fibroblasts / Q000473:pathology; D007621:Karyotyping / Q000662:veterinary; D007713:Klinefelter Syndrome / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009504:Neutrophils / Q000473:pathology; D011467:Prostate / Q000473:pathology; D012671:Seminiferous Tubules / Q000473:pathology; D013737:Testis / Q000473:pathology; D013739:Testosterone / Q000097:blood
D002843:Chromatin; D013739:Testosterone