Diversity of the biosynthesis of the isoprene units.
This review covers the biosynthesis of the starter units of terpenoids, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) via the nonmevalonate pathway together with a new enzyme involved in the conversion of IPP and DMAPP, i.e type 2 IPP isomerase. The biosynthesis of terpenoids produced by actinomycetes is also reviewed. 117 references are cited.
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan. kuz@iam.u-tokyo.ac.jp
Tomohisa
T
Kuzuyama
Haruo
H
Seto
D000190:Actinomyces / Q000378:metabolism*; D002070:Butadienes / Q000737:chemistry / Q000378:metabolism*; D019748:Carbon-Carbon Double Bond Isomerases / Q000378:metabolism*; D045782:Hemiterpenes; D008798:Mevalonic Acid / Q000737:chemistry / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000378:metabolism*; D010420:Pentanes; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism*
D002070:Butadienes; D045782:Hemiterpenes; D009943:Organophosphorus Compounds; D010420:Pentanes; D013729:Terpenes; C005059:isoprene; C004809:isopentenyl pyrophosphate; D019748:Carbon-Carbon Double Bond Isomerases; C021453:isopentenyldiphosphate delta-isomerase; D008798:Mevalonic Acid