Retrospective analysis of adverse drug reactions to bronchodilators observed in two pulmonary divisions of Catanzaro, Italy.
We retrospectively analysed the adverse drug reactions (ADRs) associated with bronchodilator therapy and reported over a 7-year period, from January 1995 to December 2001, in clinical notes of two Pulmonary division of "Mater Domini" University Hospital and "Pugliese-Ciaccio" Hospital, both located in Catanzaro, Italy. Bronchodilators were responsible for 45 (18.5%) out of 243 episodes of ADRs. Theophylline was the drug most involved in ADRs (53.4%), and skin was the body system most susceptible to ADRs induced by all bronchodilators (47.7%). We determined that the drug-ADR relationship was certain in 73% of the reports; withdrawal of the suspected drug led to recovery in 86% of cases. In conclusion, this retrospective evaluation demonstrated that bronchodilators are a common cause of ADRs in hospitalised patients and, therefore, drug surveillance can successfully identify adverse events related with drug administration in hospitalised patients.
Department of Experimental and Clinical Medicine, Clinical Pharmacology Unit, University Magna Graecia of Catanzaro, Italy.
L
L
Gallelli
G
G
Ferreri
M
M
Colosimo
D
D
Pirritano
M A
MA
Flocco
G
G
Pelaia
R
R
Maselli
G B
GB
De Sarro
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000368:Aged; D000420:Albuterol / Q000009:adverse effects / Q000031:analogs & derivatives*; D001507:Beclomethasone / Q000009:adverse effects; D001993:Bronchodilator Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004983:Ethanolamines / Q000009:adverse effects; D005260:Female; D000068759:Formoterol Fumarate; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007558:Italy; D016015:Logistic Models; D008171:Lung Diseases / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D000068299:Salmeterol Xinafoate; D013806:Theophylline / Q000009:adverse effects
D001993:Bronchodilator Agents; D004983:Ethanolamines; D000068299:Salmeterol Xinafoate; D013806:Theophylline; D001507:Beclomethasone; D000420:Albuterol; D000068759:Formoterol Fumarate