Use of a single preoperative dose of misoprostol is efficacious for patients who undergo abdominal myomectomy.
OBJECTIVE
To investigate the effectiveness of a single preoperative dose of misoprostol in abdominal myomectomies.


METHODS
Placebo-controlled randomized prospective study.


METHODS
Department of obstetrics and gynecology in a university hospital.


METHODS
Twenty-five women with symptomatic uterine leiomyomas.


METHODS
Among patients undergoing abdominal myomectomies, an hour before the operation women in the study group (n = 13) were given a single dose of vaginal misoprostol (400 microg); those in the control group (n = 12) were given placebo.


METHODS
Intraoperative blood loss, duration of operation, duration of postoperative hospitalization, and the need for blood transfusion were compared between the control and study groups.


RESULTS
Blood loss, operation time, and need for postoperative blood transfusion were significantly reduced in the group given vaginal misoprostol. No difference was observed among patients in terms of the time of hospitalization.


CONCLUSIONS
A single preoperative dose of vaginal misoprostol is a simple, reliable method for reducing intraoperative blood loss and need for postoperative blood transfusion after abdominal myomectomies.
Celik
Husnu
H
University of Firat (Euphrates), Faculty of Medicine, Departments of Obstetrics and Gynecology, Elazig, Turkey. husnucelik@hotmail.com
Sapmaz
Ekrem
E
D000282:Administration, Intravaginal; D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000601:surgery*; D016595:Misoprostol / Q000008:administration & dosage*; D011446:Prospective Studies; D014594:Uterine Neoplasms / Q000601:surgery*
D016595:Misoprostol