[Acute-phase reaction].
The systemic changes induced by inflammation have been referred as the acute-phase response. The changes in the concentrations of acute-phase proteins are due largely to changes in their production by hepatocytes induced by pro-inflammatory cytokines. Because of its specificity, sensibility and short half-life, C-reactive protein is the most useful indicator among all the acute-phase proteins. The clinical strategy to deal with an acute-phase response is to search the aetiology: infections, neoplasms, auto-immune and allergic diseases. The treatment of an acute-phase response is the treatment of its aetiology.
INSERM U. 517 faculté de médecine de Dijon, service de médecine interne, immunologie clinique. Bernard.Bonnotte@u-bourgogne.fr
Bernard
B
Bonnotte
Nils-Olivier
NO
Olsson
Bernard
B
Lorcerie
D000209:Acute-Phase Proteins / Q000494:pharmacology*; D000210:Acute-Phase Reaction / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D001327:Autoimmune Diseases / Q000150:complications; D006207:Half-Life; D006801:Humans; D007239:Infections / Q000150:complications; D009369:Neoplasms / Q000150:complications
D000209:Acute-Phase Proteins