The spindle-associated transmembrane protein Axs identifies a new family of transmembrane proteins in eukaryotes.
Axs mutations disrupt both the progression of the meiotic cell cycle and meiotic chromosome segregation in Drosophila. Axs protein co-localizes with endoplasmic reticulum components and is present within a novel structure ensheathing the meiotic spindle. We show that Axs encodes the founding member of a eukaryotic family of trans-membrane proteins.
Stowers Institute for Medical Research, Kansas City, MO 64111, USA.
Joseph
J
Kramer
R Scott
RS
Hawley
D000818:Animals; D002462:Cell Membrane / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000166:cytology / Q000378:metabolism*; D005854:Germ Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D008540:Meiosis / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D008941:Spindle Apparatus / Q000235:genetics / Q000378:metabolism*
C477507:Axs protein, Drosophila; D029721:Drosophila Proteins; D008565:Membrane Proteins