Dopamine effect on the stimulus pattern related changes in response characteristics of R/G horizontal cells in carp retina.
Repetitive red flashes increased the R/G horizontal cells' red response amplitude and induced a hyperpolarization of the cells' dark membrane potential. These phenomena were eliminated in 6-OHDA pretreated retinas and restored by exogenous dopamine, which suggests the involvement of dopamine receptor activity changes instead of dopamine release changes. Furthermore, the phenomena persisted on D(1) receptor antagonist (SKF-83566) application, whereas they diminished on D(2) receptor antagonist (eticlopride) application, indicating that the mechanism is related to a D(2) receptor, possibly located on photoreceptors.
Key Laboratory of Neurobiology, Shanghai Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China.
Yu
Y
Liu
Fu-Jun
FJ
Luo
Pei-Ji
PJ
Liang
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000031:analogs & derivatives* / Q000494:pharmacology; D018663:Adrenergic Agents / Q000494:pharmacology; D000818:Animals; D002347:Carps; D004298:Dopamine / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004347:Drug Interactions; D066298:In Vitro Techniques; D008027:Light; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D016627:Oxidopamine / Q000494:pharmacology*; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000378:metabolism*; D012160:Retina / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D012457:Salicylamides / Q000494:pharmacology; D013997:Time Factors
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D018663:Adrenergic Agents; D004298:Dopamine; D018492:Dopamine Antagonists; D016627:Oxidopamine; D017448:Receptors, Dopamine D2; D012457:Salicylamides; C044846:SKF83566; C045989:eticlopride