The bone morphogenetic proteins (BMPs). Their role in renal fibrosis and renal function.
Recently, a protein has emerged as a potential renotrophic factor: bone morphogenetic protein-7 (BMP-7). In a preventive protocol, BMP-7 treatment was found to significantly decrease renal injury in a rat model of ureteral obstruction (UUO), when treatment was initiated at the time of injury. Subsequent studies suggested that BMP-7 treatment also attenuated renal fibrosis when administered after renal fibrosis had begun. This treatment protocol was also found to increase significantly renal function from the levels measured in the vehicle-treated group. BMP-7 also partially reversed the diabetic nephropathy induced in rats by a single dose of streptozotocin. It restored glomerular filtration rate (GFR), decreased the excretion of protein, and restored histology towards normal. These studies also highlight the value of histological parameters as indicators of renal function and the potential of renal homeostatic factors in the treatment of kidney disease.
Klahr
Saulo
S
Department of Medicine, Washington University School of Medicine, Barnes-Jewish Hospital, 216 S. Kingshighway Boulevard, St. Louis, MO 63110-1092, USA. sklahr@im.wustl.edu
D058186:Acute Kidney Injury / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000378:metabolism* / Q000494:pharmacology*; D003928:Diabetic Nephropathies / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D005355:Fibrosis / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D007677:Kidney Function Tests; D011379:Prognosis; D051381:Rats; D018570:Risk Assessment; D012720:Severity of Illness Index; D016212:Transforming Growth Factor beta
C525819:BMP7 protein, human; D015415:Biomarkers; C525821:Bmp7 protein, rat; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta