Pachyclavulariolides M-R, six novel diterpenoids from a Taiwanese soft coral Pachyclavularia violacea.
Six novel diterpenoids, pachyclavulariolides M-R (1-6), have been isolated from a Taiwanese soft coral Pachyclavularia violacea. The structures and relative stereochemistry of compounds 1-6 were established by spectroscopic analyses. Compound 1 has been shown to exhibit significant cytotoxicity toward P-388 cancer cells. Biosynthesis of 4-6 is discussed.
Sheu
Jyh-Horng
JH
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw
Wang
Guey-Horng
GH
Duh
Chang-Yih
CY
Soong
Keryea
K
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003110:Colonic Neoplasms; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D007941:Leukemia P388; D008175:Lung Neoplasms; D051379:Mice; D015394:Molecular Structure; D013624:Taiwan; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D004224:Diterpenes