Polymorphisms in the genes for coagulation factor II, V, VII in patients undergoing coronary angiography.
OBJECTIVE
To determine whether polymorphisms in the genes for coagulation factor II, V, VII could predispose an individual to increase risk for coronary artery disease (CAD) and/or myocardial infarction (MI) in Chinese.


METHODS
We screened coagulation factor II(G20210A),V(G1691A),VII (R353Q and HVR4) genotype in 374 patients undergoing coronary angiography by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) assay.


RESULTS
The R353Q and HVR4 genotype of the factor VII distribution was in accordance with Hardy-Weinberg equilibrium. The frequencies of FVII genotype or allele did not show statistically significant differences between CAD group and controls or between male and female. The frequencies of the Q allele and (RQ + QQ) genotype were significantly higher among the CAD patients without myocardial infarction (MI) history than among those with MI history (P < 0.05). However, HVR4 polymorphism was not significantly different within groups. We only find one normal control of factor II (G20210A) mutation. No coagulation factor V(G1691A) mutation was found in the CAD patients and controls.


CONCLUSIONS
The factor II(G20210A) ,V(G1691A) mutation is absent and may not be a major genetic factor for CAD and/or MI; the Q allele of the R353Q polymorphism of the factor VII gene may be a protective genetic factor against myocardial infarction in Chinese.
Geng
Xu
X
The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China. xugengzju@21cn.com
Jin
Guo-Dong
GD
Fu
Guo-Sheng
GS
Ji
M A
MA
Shan
Jiang
J
Wang
Jian-An
JA
D002681:China / Q000453:epidemiology; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005167:Factor VII / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011516:Prothrombin / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
D005165:Factor V; D005167:Factor VII; D011516:Prothrombin