title: Biarylpyrimidines: a new class of ligand for high-order DNA recognition.
abstract: Biarylpyrimidines bearing omega-aminoalkyl substituents have been designed as ligands for high-order DNA structures: spectrophotometric, thermal and competition equilibrium dialysis assays showed that changing the functional group for substituent attachment from thioether to amide switches the structural binding preference from triplex to tetraplex DNA; the novel ligands are non-toxic and moderate inhibitors of human telomerase.
authors.affiliation: School of Pharmacy, University of Bradford, Bradford, West Yorkshire, UK BD7 1DP.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Murphy
authors.forename: Victoria A
authors.initials: VA
authors.lastname: Phillips
authors.forename: Sharon A
authors.initials: SA
authors.lastname: Jennings
authors.forename: Nichola C
authors.initials: NC
authors.lastname: Garbett
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Chaires
authors.forename: Terence C
authors.initials: TC
authors.lastname: Jenkins
authors.forename: Richard T
authors.initials: RT
authors.lastname: Wheelhouse
mesh_terms: D004247:DNA / Q000737:chemistry*; D006358:Hot Temperature; D008024:Ligands; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D011743:Pyrimidines / Q000737:chemistry*
chemical_list: D008024:Ligands; D011743:Pyrimidines; C051802:triplex DNA; D004247:DNA