[The pathogenicity of HFRS patient's soft palate mucosa to suckling mice].
OBJECTIVE
To explore the pathogenic mechanism of hemorrhagic fever with renal syndrome(HFRS).


METHODS
2-3 days old inbred Balb/C suckling mice were inoculated intracerebrally with tissue suspension of soft palate petechia of HFRS patients and the HFRS virus RNA was tested in brain, lung and kidney tissues of sucking mice by nested PCR.


RESULTS
Some of the mice developed acute disease and died. The autopsy analysis indicated that these mice showed pathological changes in microvascular system and parenchymatous tissues. HFRS virus RNA was detected in their brains, lungs and kidney tissues.


CONCLUSIONS
These results indicate that HFRS virus exists in the tissue of petechial hemorrhagic spots on soft palate petechia of HFRS patients.
Zhang
L
L
First Military Medical University, Guangzhou 510515.
Zhang
L
L
Wang
S
S
D000818:Animals; D000833:Animals, Suckling; D006476:Orthohantavirus / Q000235:genetics / Q000472:pathogenicity*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000209:etiology* / Q000473:pathology; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D009092:Mucous Membrane / Q000821:virology*; D010160:Palate, Soft / Q000033:anatomy & histology* / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D014774:Virulence
D012367:RNA, Viral