title: Region 4 of sigma as a target for transcription regulation.
abstract: Bacterial sigma factors play a key role in promoter recognition, making direct contact with conserved promoter elements. Most sigma factors belong to the sigma70 family, named for the primary sigma factor in Escherichia coli. Members of the sigma70 family typically share four conserved regions and, here, we focus on region 4, which is directly involved in promoter recognition and serves as a target for a variety of regulators of transcription initiation. We review recent advances in the understanding of the mechanism of action of regulators that target region 4 of sigma.
authors.affiliation: Division of Infectious Diseases, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Simon L
authors.initials: SL
authors.lastname: Dove
authors.forename: Seth A
authors.initials: SA
authors.lastname: Darst
authors.forename: Ann
authors.initials: A
authors.lastname: Hochschild
mesh_terms: D010582:Bacteriophage lambda / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D012808:Sigma Factor / Q000235:genetics* / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D012808:Sigma Factor