title: The epithelial calcium channels, TRPV5 & TRPV6: from identification towards regulation.
abstract: The epithelial calcium channels, TRPV5 and TRPV6, have been extensively studied in epithelial tissues controlling the Ca(2+) homeostasis and exhibit a range of distinctive properties that distinguish them from other TRP channels. This review focuses on the tissue distribution, the functional properties, the architecture and the regulation of the expression and activity of the TRPV5 and TRPV6 channel.
authors.affiliation: Department of Cell Physiology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, 160 Cell Physiology, P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands.
authors.forename: Els
authors.initials: E
authors.lastname: den Dekker
authors.forename: Joost G J
authors.initials: JG
authors.lastname: Hoenderop
authors.forename: Bernd
authors.initials: B
authors.lastname: Nilius
authors.forename: René J M
authors.initials: RJ
authors.lastname: Bindels
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000737:chemistry / Q000502:physiology*; D004848:Epithelium / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D050916:TRPV Cation Channels
chemical_list: D015220:Calcium Channels; D050916:TRPV Cation Channels; C492239:TRPV5 protein, human; C120776:TRPV6 channel; D002118:Calcium