Wave propagation in an excitable medium with a negatively sloped restitution curve.
Recent experimental studies show that the restitution curve of cardiac tissue can have a negative slope. We study how the negative slope of the restitution curve can influence basic processes in excitable media, such as periodic forcing of an excitable cell, circulation of a pulse in a ring, and spiral wave rotation in two dimensions. We show that negatively sloped restitution curve can result in instabilities if the slope of the restitution curve is steeper than -1 and report different manifestations of this instability. (c) 2002 American Institute of Physics.
Panfilov
A. V.
AV
Department of Theoretical Biology, Utrecht University, Padualaan 8, Utrecht, 3584, The Netherlands.
Zemlin
C. W.
CW