title: Differentiating primary central nervous system lymphoma from glioma in humans using localised proton magnetic resonance spectroscopy.
abstract: In order to characterise primary central nervous system lymphomas (PCNSL) and to evaluate if 1H spectroscopy improves the preoperative differential diagnosis of PCNSL and glioma, seven immunocompetent patients with PCNSL and 21 patients with glioma were examined using single voxel, short echo time magnetic resonance spectroscopy (MRS; 1.5 T, STEAM 1500/20). All PCNSL demonstrated massively elevated lipid resonances and markedly elevated choline. Similarly increased lipid resonances were only found in seven necrotic glioblastomas, PCNSL differing from all solid astrocytomas by massively elevated lipid resonances. Additionally, PCNSL had higher Cho/Cr ratios than all grades of astrocytoma. In conclusion, we found that massively elevated lipid resonances are a hallmark of PCNSL in immunocompetent patients. Together with a markedly elevated Cho/Cr ratio, MRS provides metabolic information which may improve the preoperative differentiation of PCNSL and glioma.
authors.affiliation: Division of Neuroradiology, Department of Neurology, University of Heidelberg Medical Centre, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. inga_harting@med.uni-heidelberg.de
authors.forename: Inga
authors.initials: I
authors.lastname: Harting
authors.forename: Marius
authors.initials: M
authors.lastname: Hartmann
authors.forename: Gregor
authors.initials: G
authors.lastname: Jost
authors.forename: Clemens
authors.initials: C
authors.lastname: Sommer
authors.forename: Rezvan
authors.initials: R
authors.lastname: Ahmadi
authors.forename: Sabine
authors.initials: S
authors.lastname: Heiland
authors.forename: Klaus
authors.initials: K
authors.lastname: Sartor
mesh_terms: D016543:Central Nervous System Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D002794:Choline / Q000032:analysis; D003937:Diagnosis, Differential; D005910:Glioma / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D007121:Immunocompetence / Q000502:physiology; D008055:Lipids / Q000032:analysis; D008223:Lymphoma / Q000175:diagnosis* / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*
chemical_list: D008055:Lipids; D002794:Choline