Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis.
We tested whether a regular exercise regimen was associated with a change in the life span of G93A-SOD1 transgenic mice, a model of familial ALS. Regular treadmill running for 10 weeks led to a significant increase in the life span of G93A-SOD1 mice. The effect was stronger in male mice, whereas there was only a trend between exercised and sedentary female G93A-SOD1 mice. The data suggest that regular exercise has a beneficial effect on the progression of ALS.
Kirkinezos
Ilias G
IG
Department of Cell Biology, University of Miami School of Medicine, Miami, FL 33136, USA.
Hernandez
Dayami
D
Bradley
Walter G
WG
Moraes
Carlos T
CT
D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics / Q000628:therapy*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D010805:Physical Conditioning, Animal; D012737:Sex Factors