title: Clinical over- and under-estimation in patients who underwent hysterectomy for atypical endometrial hyperplasia diagnosed by endometrial biopsy: the predictive value of clinical parameters and diagnostic imaging.
abstract: OBJECTIVE
  The aim of this study was to analyze the clinical and imaging characteristics in patients diagnosed with atypical endometrial hyperplasia based on endometrial biopsy in comparison with the final diagnosis from resected uteri; i.e. to determine the rates of underestimation (endometrial cancer), equivalent diagnosis (atypical hyperplasia), and overestimation (hyperplasia without atypia or non-hyperplastic lesion).
  
  
  METHODS
  We reviewed 33 patients who were diagnosed with atypical endometrial hyperplasia by endometrial biopsy using a small curette and then underwent total abdominal hysterectomy between September 1992 and May 2002. Clinical parameters obtained from patients' charts, and imaging analyses using transvaginal ultrasonography (TUS) and magnetic resonance (MR) imaging were retrospectively re-examined.
  
  
  RESULTS
  Among 33 patients who underwent hysterectomy due to a diagnosis of atypical hyperplasia, nine cases (27.2%) were underestimated (cancer), nine cases (27.2%) were equivalent and 15 cases (45.6%) were overestimated as indicated by examination of the endometrium of the resected uterus. There was no difference among these groups in either clinical parameters or diagnostic images obtained by TUS or MR.
  
  
  CONCLUSIONS
  Diagnosis of atypical endometrial hyperplasia by endometrial biopsy often resulted in under- or over-estimation, as shown by examination after hysterectomy. As there is neither a reliable clinical parameter nor imaging feature to distinguish between these groups, hysterectomy is still the best treatment for these patients if they are willing to give up their fertility.
authors.affiliation: Department of Gynecology, Osaka Medical Center for Cancer and Cardiovasucular Diseases, 1-3-3 Nakamichi, Higashinari, 5378511, Osaka, Japan. tadashi@gyne.med.osaka-u.ac.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kimura
authors.forename: Shoji
authors.initials: S
authors.lastname: Kamiura
authors.forename: Toshiko
authors.initials: T
authors.lastname: Komoto
authors.forename: Hozumi
authors.initials: H
authors.lastname: Seino
authors.forename: Kumiko
authors.initials: K
authors.lastname: Tenma
authors.forename: Yukinobu
authors.initials: Y
authors.lastname: Ohta
authors.forename: Toshiya
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Saji
mesh_terms: D000328:Adult; D001706:Biopsy; D004714:Endometrial Hyperplasia / Q000175:diagnosis* / Q000601:surgery*; D016889:Endometrial Neoplasms / Q000473:pathology; D004717:Endometrium / Q000473:pathology*; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D014463:Ultrasonography