Unwinding of DNA polymerases by the antitumor drug, cis-diamminedichloroplatinum(II).
The helix-turn-helix motifs of the DNA binding domains of human polymerase-alpha and polymerase-kappa are dramatically perturbed upon binding to cisplatin with concomitant release of zinc.
Volckova
Erika
E
Department of Chemistry, School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA.
Evanics
Ferenc
F
Yang
Wei W
WW
Bose
Rathindra N
RN
D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites; D002942:Circular Dichroism; D002945:Cisplatin / Q000378:metabolism / Q000494:pharmacology*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D017434:Protein Structure, Tertiary / Q000187:drug effects
D000970:Antineoplastic Agents; D004268:DNA-Binding Proteins; D004259:DNA-Directed DNA Polymerase; D002945:Cisplatin