title: [Analysis of the epidemiological data concerning radiation carcinogenic effects and approaches to the low doses' upper limits determination in the aspect of a threshold of the unhealthy influences of ionizing radiation].
abstract: The analysis of the epidemiological data regarding cancer mortality in cohorts of Japanese A-bomb survivors and Chermobyl liquidators exposed to different doses suggests that there are good reasons for recognizing the threshold of the radiocarcinogenic effect in the region of about 200 Gy (mSv). The analysis of solid cancer mortality in Japanese cohort, which exceeded the expected one in a dose diapason of 5-200 mSv, revealed a (quasi) plateau in a dose-effect curve and led to the conclusion that the nature of the overshoot is non-radiogenic. The analysis of supposedly dose dependent leucosis incidence in the limited low dose diapason in the Chernobyl cohort showed that the real coefficient of the excess absolute or relative radiation risk could not be received in the case because the larger part curve was placed under the control level. In supporting the principle of single hit in a cell nucleus as a base of microdosimetric determination of low radiation doses, the approach to objective delimitation between low, intermediate and high doses regions has been proposed. The low doses upper limit of sparse ionizing radiation for cell nucleus of 8 microns in diameter has been evaluated as 0.65 mGy. It can serve for evaluation of the dose rate threshold regarding the safe chronic radiation levels in the environment.
authors.affiliation: State Research Center-Institute of Biophysics, Russian Ministry of Health, Moscow, 123182 Russia. rol@scribph.ru
authors.forename: L M
authors.initials: LM
authors.lastname: Rozhdestvenskiĭ
mesh_terms: D002467:Cell Nucleus / Q000528:radiation effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D015331:Cohort Studies; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007953:Leukemia, Radiation-Induced / Q000453:epidemiology / Q000401:mortality; D008214:Lymphocytes / Q000528:radiation effects; D008962:Models, Theoretical; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000401:mortality; D009689:Nuclear Warfare; D009790:Occupations; D011210:Power Plants; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000453:epidemiology* / Q000401:mortality; D011839:Radiation, Ionizing; D011847:Radioactive Fallout; D018788:Radioactive Hazard Release; D011874:Radiometry; D013997:Time Factors; D014455:Ukraine / Q000453:epidemiology
chemical_list: D011847:Radioactive Fallout