title: Ibuprofen and acetaminophen: effect on muscle inflammation after eccentric exercise.
abstract: OBJECTIVE
  We examined the influence of ibuprofen and acetaminophen on muscle neutrophil and macrophage concentrations after novel eccentric contractions.
  
  
  METHODS
  Twenty-four males (25 +/- 3 yr) were divided into three groups that received the maximal over-the-counter dose of either ibuprofen (1200 mg x d-1), acetaminophen (4000 mg x d-1), or a placebo after eccentric contractions of the knee extensors. Biopsies from the vastus lateralis were taken before and 24 h after exercise. Inflammatory cells were quantified in muscle cross-sections using immunohistochemistry.
  
  
  RESULTS
  Macrophage concentrations were elevated by 1.5- to 2.5-fold (P < 0.05) at 24 h postexercise relative to preexercise concentrations, whereas neutrophil concentrations were not significantly elevated. Muscle inflammatory cell concentrations were unaffected by treatment with ibuprofen or acetaminophen when compared with placebo.
  
  
  CONCLUSIONS
  Maximal over-the-counter doses of ibuprofen or acetaminophen, when administered therapeutically, do not affect muscle concentrations of neutrophils or macrophages 24 h after a novel bout of eccentric contractions.
authors.affiliation: The University of Toledo, Department of Kinesiology, OH 43606, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Peterson
authors.forename: Todd A
authors.initials: TA
authors.lastname: Trappe
authors.forename: Eleni
authors.initials: E
authors.lastname: Mylona
authors.forename: Faber
authors.initials: F
authors.lastname: White
authors.forename: Charles P
authors.initials: CP
authors.lastname: Lambert
authors.forename: William J
authors.initials: WJ
authors.lastname: Evans
authors.forename: Francis X
authors.initials: FX
authors.lastname: Pizza
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000494:pharmacology*; D000284:Administration, Oral; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004311:Double-Blind Method; D015444:Exercise; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology*; D007249:Inflammation; D008264:Macrophages; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology*; D009504:Neutrophils
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D007052:Ibuprofen