ABO System: molecular mimicry of Ascaris lumbricoides.
A. lumbricoides has been associated to the ABO System by various authors. The objective was to detect ABO System epitopes in A. lumbricoides of groups O, A, B and AB patients. 28 adult parasites were obtained from children to be used as assay material. The patients ABO blood groups were determined. Extracts of A. lumbricoides [AE] were prepared by surgical remotion of the cuticle and refrigerated mechanical rupture. Agglutination Inhibition (AI) and Hemoagglutination Kinetics (HK) tests were used with the [AE]. Of the 28 [AE], eight belonged to O group patients, 15 to A group, three to B group and the remaining two to AB children. The AI Test showed A epitopes in two [AE] of group A patients and B epitopes in two [AE] of group B patients. The HK Test showed B antigenic determiners in two [AE] of group B patients and in two [AE] of group AB patients as well as A antigenic determiners in one [AE] of A group patient. Of the 28 [AE] studied in both tests B epitopes were detected in all [AE] from B and AB patients and A epitopes in three of the 15 [AE] of group A patients. The experiments carried out suggest that A. lumbricoides might absorb A and B antigens from the host, and/or modify the cuticular carbohydrates expression as a kind of antigenic mimicry.
Ponce de León
Patricia
P
Faculdade de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
Valverde
Juana
J
D000017:ABO Blood-Group System / Q000276:immunology*; D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D017164:Ascaris lumbricoides / Q000276:immunology*; D002648:Child; D000939:Epitopes / Q000032:analysis*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007700:Kinetics; D018716:Molecular Mimicry / Q000276:immunology*
D000017:ABO Blood-Group System; D000947:Antigens, Helminth; D000939:Epitopes