title: Helicobacter pylori infection induces interleukin-8 receptor expression in the human gastric epithelium.
abstract: The gastric pathogen Helicobacter pylori is known to activate multiple proinflammatory signaling pathways in epithelial cells. In this study, we addressed the question of whether expression of the interleukin-8 receptors IL-8RA (CXCR1) and IL-8RB (CXCR2) is upregulated in H. pylori-infected human gastric biopsy samples. Biopsy samples from patients infected with H. pylori strains harboring the cag pathogenicity island (PAI) expressed larger amounts of both receptors. In addition, IL-8RB expression was induced in the gastric epithelial cell line AGS upon infection with a clinical isolate containing the cag PAI, while a strain lacking the cag PAI did not. Our finding suggests that gastric epithelial cells express IL-8R in response to H. pylori infection.
authors.affiliation: Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden. fbackhed@pcg.wustl.edu
authors.forename: Fredrik
authors.initials: F
authors.lastname: Bäckhed
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Torstensson
authors.forename: Delphine
authors.initials: D
authors.lastname: Seguin
authors.forename: Agneta
authors.initials: A
authors.lastname: Richter-Dahlfors
authors.forename: Bachra
authors.initials: B
authors.lastname: Rokbi
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D008297:Male; D008875:Middle Aged; D023062:Receptors, Interleukin-8A / Q000096:biosynthesis*; D023063:Receptors, Interleukin-8B / Q000096:biosynthesis*; D015854:Up-Regulation; D014774:Virulence / Q000235:genetics
chemical_list: D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B