[The value of autofluorescence spectrum analysis of gastric juice in diagnosing gastric carcinoma: a preliminary result].
OBJECTIVE
To reveal the difference of autofluorescence spectrums of gastric juice derived from malignancy and benignancy for screening and diagnosis of gastric carcinoma.


METHODS
Gastric juice from 202 patients with different gastric diseases were collected, then detected their autofluorescence spectrums (the excitation wavelength is 288 nm, whereas the range of emission wavelength is 300 - 800 nm) after diluted by 1:10. The diagnostic model for gastric cancer was made by Classification and Regression Trees V2.0 software.


RESULTS
There were three peaks (the emission wavelength were 320 - 360 nm, 576 nm and 670 - 690 nm respectively) in the autofluorescence spectrums of all patients, though the intensity of the first peak (with the emission wavelength of 320 - 360 nm) were enhanced distinctively in malignance than those in benignancy. The diagnostic model's sensitivity and specificity of prior probability were 91.4% and 83.2% respectively, whereas the sensitivity and specificity of posterior probability were 85.7% and 82.6%.


CONCLUSIONS
Detection of autofluorescence spectrum of gastric juice has great prospect in the diagnosis and screening gastric carcinoma.
Li
Yuan
Y
Department of Gastroenterology, The Third Hospital, Peking University, Beijing 100083, China. Leeyuan@yahoo.com.cn
Lin
San-ren
SR
Zhou
Li-ya
LY
Guo
Hui-lan
HL
Ye
Si-mao
SM
Jin
Zhu
Z
Geng
Qiu-ming
QM
Zhao
Yi-ming
YM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005750:Gastric Juice / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence; D013057:Spectrum Analysis; D013274:Stomach Neoplasms / Q000175:diagnosis*