title: The association of the expression of vascular endothelial growth factor with the cystic component and haemorrhage in pituitary adenoma.
abstract: Vascular endothelial growth factor (VEGF) is known to be a mediator of angiogenesis and vascular permeability. A cystic component and haemorrhage are often found in pituitary adenomas. We assessed the VEGF expression based on immunohistochemical examinations in 48 pituitary adenomas. All the adenomas showed some VEGF immunoreactivity mainly in the cytoplasm of tumour cells. Of the 48 adenoma-cases, 16 cases had a strong VEGF immunoreactivity, 26 cases had a moderate one, and 6 cases had a weak one. On the MR images, a cystic component was found in 16 cases (33.3%), and a haemorrhage was found in 18 cases (37.5%). The VEGF immunoreactivity had a significant relationship with the cystic component but not the haemorrhage, size, recurrence, or HE classification. These findings suggest that VEGF plays any potential role in the pathogenesis of cystic formation in pituitary adenomas.
authors.affiliation: Department of Neurosurgery, National Defense Medical College, 3-2 Namiki, Saitama 359-8513, Tokorozawa, Japan. grd1309@gr.ndmc.ac.jp
authors.forename: Shinji
authors.initials: S
authors.lastname: Fukui
authors.forename: Naoki
authors.initials: N
authors.lastname: Otani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nawashiro
authors.forename: Akiko
authors.initials: A
authors.lastname: Yano
authors.forename: Namiko
authors.initials: N
authors.lastname: Nomura
authors.forename: Aya M
authors.initials: AM
authors.lastname: Tokumaru
authors.forename: Takahito
authors.initials: T
authors.lastname: Miyazawa
authors.forename: Akira
authors.initials: A
authors.lastname: Ohnuki
authors.forename: Nobusuke
authors.initials: N
authors.lastname: Tsuzuki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Katoh
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Ishihara
authors.forename: Katsuji
authors.initials: K
authors.lastname: Shima
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Ooigawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003560:Cysts / Q000000981:diagnostic imaging / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D011859:Radiography; D012008:Recurrence; D012189:Retrospective Studies; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D014965:X-Rays; D055815:Young Adult
chemical_list: D042461:Vascular Endothelial Growth Factor A