Acetylenic acids from the aerial parts of Nanodea muscosa.
The aerial parts of Nanodea muscosa, collected in Chile, yielded two new acetylenic acids. Their structures were elucidated by spectroscopic analyses, including 2D NMR techniques, as (13E)-octadec-13-en-11-ynoic acid (1) and (2E)-octadec-2-en-4-ynedioic acid (2). Compound 2 constitutes the first example of a conjugated ene-yne fatty diacid isolated from a natural source. Compounds 1 and 2 did not exhibit toxicity toward a panel of DNA damage checkpoint defective yeast mutants or show affinity for the 5-HT(1A), 5-HT(2A), D(2), and H(1) receptors.
El-Jaber
N
N
Instituto Universitario de Bio-Orgánica Antonio González-González, Avenida Astrofísico Fco. Sánchez No. 2, La Laguna, 38206 Tenerife, Spain.
Estévez-Braun
A
A
Ravelo
A G
AG
Muñoz-Muñoz
O
O
Rodríguez-Afonso
A
A
Murguia
J R
JR
D000480:Alkynes; D002677:Chile; D004249:DNA Damage / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2 / Q000187:drug effects; D011969:Receptors, Histamine H1 / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D044263:Receptors, Serotonin, 5-HT1; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D029630:Santalaceae / Q000737:chemistry*; D013237:Stereoisomerism
D000480:Alkynes; D005231:Fatty Acids, Unsaturated; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2; D011969:Receptors, Histamine H1; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; C031203:2-hexadecynoic acid