title: [Prevalence of infections by hepatitis A, B, C and E viruses in two different socioeconomic groups of children from Santa Cruz, Bolivia].
abstract: OBJECTIVE
  The epidemiology of hepatitis A, E, B and C was analyzed in 1,393 children living in Santa Cruz de la Sierra, Bolivia. They were distributed in two groups according to the social condition.
  
  
  METHODS
  1,393 children were selected from two different schools: one attended by children belonging to a high social class of the town (group A), and the other school attended by children belonging to the poorest social class (group B). Blood samples were drawn by a team of physicians from Rome University La Sapienza. Serum antibodies against hepatitis A, B, C and E virus, and the hepatitis B surface antigen were evaluated by immunometric methods. The significance was evaluated using the *2 test.
  
  
  RESULTS
  Antibodies against hepatitis A virus were detected in 82% of examined children, with a significant difference between the two groups (56.3% vs 94.8%). The incidence of anti-HBc antibodies increased with age, so the infection is acquired prevalently in adolescence with a significant difference between both groups (1.1% vs 3.8%). The same phenomenon was observed with anti-HCV antibodies (4.7% positivity only in group B). Serum antibodies against hepatitis E virus were observed in 1.7% cases.
  
  
  CONCLUSIONS
  In Bolivia, as in other developing countries, viral hepatitis represents a serious burden for public health. Spreading of viral hepatitis can be controlled upon improving hygienic conditions and customs. Moreover, a vaccination plan against hepatitis A and B virus is necessary for the population living in endemic areas.
authors.affiliation: Department of Experimental Medicine and Pathology. Rome University La Sapienza. Rome. Italy. giugando@hotmail.com
authors.forename: Giuseppe M
authors.initials: GM
authors.lastname: Gandolfo
authors.forename: Giovanni M
authors.initials: GM
authors.lastname: Ferri
authors.forename: Laura
authors.initials: L
authors.lastname: Conti
authors.forename: Anna
authors.initials: A
authors.lastname: Antenucci
authors.forename: Rosalia
authors.initials: R
authors.lastname: Marrone
authors.forename: Anna M
authors.initials: AM
authors.lastname: Frasca
authors.forename: Gaetano
authors.initials: G
authors.lastname: Vitelli
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D001838:Bolivia / Q000453:epidemiology; D002648:Child; D005260:Female; D006506:Hepatitis A / Q000453:epidemiology / Q000276:immunology; D006509:Hepatitis B / Q000453:epidemiology / Q000276:immunology; D006526:Hepatitis C / Q000453:epidemiology / Q000276:immunology; D016751:Hepatitis E / Q000453:epidemiology / Q000276:immunology; D006518:Hepatitis Viruses / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D008297:Male; D015995:Prevalence; D012959:Socioeconomic Factors
chemical_list: D000914:Antibodies, Viral