[Effects of alcoholism on auditory event-related potential in fetal rats].
OBJECTIVE
To study the effects of embryonic alcoholism, with an animal model of auditory event-related potential (AERP) recorded in the conditions of various alcohol dosages administrated during the auditory center nervous system development, on the perceptive functions in young Sprague-Dawley rats.


METHODS
Normal female rats were divided into 3 groups. From the days 8.5 to 14 after mating, pregnant rats were fed 75% analytical reagent alcohol via stomach tube with 2.0, 1.0 and 0.1 g.kg-1.d-1 respectively. On the days 30-40 after birth, AERP was recorded in young rats with passive mode under anesthesia. Normal young rats with parallel age were chosen as the normal group.


RESULTS
AERP was not affected after administration of the low dosage alcohol. Nevertheless, AERP was affected after administration of the middle and high dosages, manifesting the incidence rate lowing or response disappearing, latency delaying, amplitude reducing and waveform distorting, especially shorter waves of AERP.


CONCLUSIONS
The alcoholism would produce apparent effects with dosage-effect relationship on the responsibility of auditory center during development in fetal rats, which reflected that there was a direct tie between the responsibility of AERP and the function of auditory center.
Liang
Yong
Y
Department of Otorhinolaryngology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. yliang@fimmu.edu.cn
Wang
Zhengmin
Z
Qu
Weidong
W
D000437:Alcoholism; D000818:Animals; D001303:Auditory Cortex / Q000187:drug effects* / Q000196:embryology / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005072:Evoked Potentials, Auditory; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley