New lysophosphatidylcholines and monoglycerides from the marine sponge Stelletta sp.
Two new lysophosphatidylcholines (1, 2) and four new monoglycerides (5-8) were isolated from the marine sponge Stelletta sp. by bioactivity-guided fractionation. The planar structures of the new compounds were established on the basis of NMR and MS analyses. The stereochemistry was defined by comparison of the optical rotation. The compounds were evaluated for cytotoxicity against a small panel of five human tumor cell lines.
Zhao
Qingchun
Q
College of Pharmacy, Pusan National University, Busan 609-735, Korea.
Mansoor
Tayyab A
TA
Hong
Jongki
J
Lee
Chong-O
CO
Im
Kwang Sik
KS
Lee
Dong Seok
DS
Jung
Jee H
JH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005989:Glycerides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms; D008244:Lysophosphatidylcholines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010051:Ovarian Neoplasms; D010713:Phosphatidylcholines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*
D000970:Antineoplastic Agents; D005989:Glycerides; D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; C478193:stellettacholine A; C478194:stellettacholine B