[Non-monotonous dose-response relationship in the region of low doses of ionizing radiation].
The statement about nonmonotony of dose-effect curves as a result of nonmonotony of the time-effect relationship including the field of low doses is discussed. The living cells possess a fundamental property to response to action of different stress agents by oscillatory--nonmonotonous--hanges of metabolism. The systems keeping up homeostasis by direct and feed-back regulation return metabolism to norm. In the fixed temporary point a dose-effect dependence may take the nonmonotonous character e.g. reverse dose-response relationship. The changes of the oscillation parameters suggested the inclusion of the different pathway for homeostasis keeping. Radiation hormesis does not focused on the metabolic and functional nonmonotonous response. Radiation stimulation is considered as consequence of the peculiarity of the homeostasis maintenance pathways in the certain interval of the low doses of ionizing radiation.
Kolomiĭtseva
I K
IK
Institute of Cell Biophysics, Russian Academy of Science, Pushchino, 142290 Russia. Kolomiytseva@icb.psn.ru
D000222:Adaptation, Physiological; D000818:Animals; D002477:Cells / Q000378:metabolism / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006706:Homeostasis; D010812:Physical Stimulation; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D013997:Time Factors