title: Association analysis of the insertion/deletion polymorphism in serotonin transporter gene in patients with affective disorder.
abstract: A polymorphism of serotonin transporter was studied in 226 patients with affective disorders (n = 132 for bipolar, n = 94 for unipolar affective disorder) and in 213 healthy subjects. Consensus diagnosis by at least two psychiatrists, according to the ICD-10 and DSM-IV criteria was made for each patient using SCID (Structured Clinical Interview for DSM-IV Axis I Disorders). A functional polymorphism in the promoter region of serotonin transporter gene, where 44 bp are either inserted (long allele) or deleted (short allele) was analysed. Genotype s/s was significantly more frequent in patients comparing to the control group (P = 0.011 for bipolar and P = 0.003 for unipolar affective disorder)--the most marked association was found in males with bipolar and unipolar illness. The allele frequencies also differ significantly between patients and controls (P = 0.003 for bipolar and P = 0.001 for unipolar affective disorder). The frequency of the low activity (short) allele was higher in patients than in controls (51.1% in bipolar, and 54.3 in unipolar vs 39.4% in controls). We suggest that the presence of allele s may increase the susceptibility to occurrence of affective disorder.
authors.affiliation: Department of Adult Psychiatry, University of Medical Sciences, Poznan, Poland. j.hauser@wp.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Hauser
authors.forename: Anna
authors.initials: A
authors.lastname: Leszczyńska
authors.forename: Jerzy
authors.initials: J
authors.lastname: Samochowiec
authors.forename: Piotr M
authors.initials: PM
authors.lastname: Czerski
authors.forename: Agata
authors.initials: A
authors.lastname: Ostapowicz
authors.forename: Maria
authors.initials: M
authors.lastname: Chlopocka
authors.forename: Jan
authors.initials: J
authors.lastname: Horodnicki
authors.forename: Janusz K
authors.initials: JK
authors.lastname: Rybakowski
mesh_terms: D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D019964:Mood Disorders / Q000175:diagnosis / Q000235:genetics*; D009419:Nerve Tissue Proteins; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D017384:Sequence Deletion; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin