Lack of vancomycin tolerance in Streptococcus pneumoniae strains isolated in Barcelona, Spain, from 1999 to 2001.
To evaluate the incidence of vancomycin tolerance among Streptococcus pneumoniae isolates, we performed killing curve studies with 633 isolates. The penicillin MIC was > or = 0.12 mg/liter for 481 (76%) of the isolates. All strains were susceptible to vancomycin. Killing curve studies were performed with a vancomycin concentration of 2.5 mg/liter. The Tupelo strain was used for quality control. No vancomycin-tolerant strain was detected.
Ortega
Mar
M
Infectious Diseases Unit, Institute of Infectious Diseases and Immunology, Hospital Clínic, Barcelona, Spain. marortegaromero@yahoo.es
Marco
Francesc
F
Soriano
Alex
A
García
Elisa
E
Martínez
José A
JA
Mensa
Josep
J
D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D011008:Pneumococcal Infections / Q000382:microbiology; D013030:Spain; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D014640:Vancomycin / Q000494:pharmacology*; D020713:Vancomycin Resistance
D010406:Penicillins; D014640:Vancomycin