title: Brominated polyacetylenes from the Philippines sponge Diplastrella sp.
abstract: Five novel brominated polyacetylenic diols, diplynes A-E (2-6), and three sulfated analogues, diplyne A 1-sulfate (7), diplyne C 1-sulfate (8), and 2-deoxydiplyne D sulfate (9), were isolated from the Philippines sponge Diplastrella sp. by employing bioassay-guided fractionation using the HIV-1 integrase inhibition assay. The novel metabolites were characterized by interpretation of spectroscopic data.
authors.affiliation: Scripps Institution of Oceanography, University of California at San Diego, 9500 Gilman Drive, La Jolla 92093-0212, USA. mlerch@ucsd.edu
authors.forename: Melissa L
authors.initials: ML
authors.lastname: Lerch
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Harper
authors.forename: D John
authors.initials: DJ
authors.lastname: Faulkner
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D019428:HIV Integrase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010679:Philippines; D011108:Polymers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053279:Polyynes; D011161:Porifera / Q000737:chemistry*
chemical_list: D019428:HIV Integrase Inhibitors; D006842:Hydrocarbons, Brominated; D011108:Polymers; D053279:Polyynes; D000114:Acetylene