title: Elevated osteopontin levels in active relapsing-remitting multiple sclerosis.
abstract: In the search for proteins that might play a role in the pathogenesis of multiple sclerosis (MS), osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene expressed within MS lesions. Here, we report significantly increased OPN protein levels in plasma of relapsing-remitting MS patients. In contrast, OPN protein levels in primary progressive and secondary progressive MS patients were similar to healthy control levels. Interestingly, active relapsing-remitting patients had higher OPN protein levels than patients without relapses.
authors.affiliation: Division of Immunological and Infectious Diseases, TNO Prevention and Health, Leiden, The Netherlands. mhj.vogt@pg.tno.nl
authors.forename: Mario H J
authors.initials: MH
authors.lastname: Vogt
authors.forename: Luba
authors.initials: L
authors.lastname: Lopatinskaya
authors.forename: Monique
authors.initials: M
authors.lastname: Smits
authors.forename: Chris H
authors.initials: CH
authors.lastname: Polman
authors.forename: Lex
authors.initials: L
authors.lastname: Nagelkerken
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000378:metabolism*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000378:metabolism*; D053495:Osteopontin; D012795:Sialoglycoproteins / Q000097:blood / Q000378:metabolism*
chemical_list: C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D053495:Osteopontin