title: Effect of galanin on plasma glucose, insulin and pancreatic glucagon in dogs.
abstract: The effect of synthetic galanin on plasma glucose, insulin and pancreatic glucagon levels in dogs was studied. Infusion of galanin caused a rapid, reversible and dose-dependent reduction in basal insulin level. A maximal increase in blood glucose level accompanying the insulin decrease was observed when galanin was administered at a dose of 4 micrograms/kg per h. Pancreatic glucagon levels showed little change compared with basal secretion. These results indicate that galanin is involved in the regulation of glucose through control of insulin secretion.
authors.affiliation: Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. mnb@med.nagoya-cu.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Manabe
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
authors.forename: H
authors.initials: H
authors.lastname: Sawai
authors.forename: H
authors.initials: H
authors.lastname: Funahashi
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Hayakawa
authors.forename: T
authors.initials: T
authors.lastname: Yoshimura
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D019004:Galanin / Q000008:administration & dosage*; D005934:Glucagon / Q000097:blood / Q000378:metabolism*; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D019004:Galanin; D005934:Glucagon