title: Clearance of 14-3-3 protein from cerebrospinal fluid heralds the resolution of bacterial meningitis.
abstract: The 14-3-3 protein, a cerebrospinal fluid (CSF) marker of neuronal damage that was recently adopted for the diagnosis of Creutzfeldt-Jakob disease, is also found in the CSF of patients with a variety of neurological disorders. We prospectively studied 12 consecutive patients with purulent bacterial meningitis and found that 14-3-3 protein was detected in all patients at admission to the hospital. All patients who recovered cleared 14-3-3 protein from the CSF before discharge from the hospital (this was the first CSF marker to clear), whereas those who died never cleared the protein.
authors.affiliation: Department of Infectious Diseases, University of Turin, Turin, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Bonora
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Zanusso
authors.forename: Riccardo
authors.initials: R
authors.lastname: Raiteri
authors.forename: Salvatore
authors.initials: S
authors.lastname: Monaco
authors.forename: Antonella
authors.initials: A
authors.lastname: Rossati
authors.forename: Sergio
authors.initials: S
authors.lastname: Ferrari
authors.forename: Marta
authors.initials: M
authors.lastname: Boffito
authors.forename: Sabrina
authors.initials: S
authors.lastname: Audagnotto
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sinicco
authors.forename: Nicola
authors.initials: N
authors.lastname: Rizzuto
authors.forename: Ercole
authors.initials: E
authors.lastname: Concia
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Perri
mesh_terms: D048948:14-3-3 Proteins; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002556:Cerebrospinal Fluid Proteins / Q000134:cerebrospinal fluid*; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid; D006801:Humans; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000401:mortality; D011379:Prognosis; D011446:Prospective Studies; D014446:Tyrosine 3-Monooxygenase / Q000134:cerebrospinal fluid*
chemical_list: D048948:14-3-3 Proteins; D015415:Biomarkers; D002556:Cerebrospinal Fluid Proteins; D014446:Tyrosine 3-Monooxygenase