Vaccine research efforts for filoviruses.
Ebola and Marburg viruses belong to the family Filoviridae, and cause acute, frequently fatal, haemorrhagic fever in humans and non-human primates. No vaccines are available for human use. This review describes the status of research efforts to develop vaccines for these viruses and to identify the immune mechanisms of protection. The vaccine approaches discussed include DNA-based vaccines, and subunit vaccines vectored by adenovirus, alphavirus replicons, and vaccinia virus.
Hart
Mary Kate
MK
Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702-5011, USA. marykate.hart@amedd.army.mil
D000818:Animals; D029043:Ebolavirus / Q000235:genetics / Q000276:immunology; D004666:Encephalitis Virus, Venezuelan Equine / Q000276:immunology; D016563:Filoviridae / Q000276:immunology*; D018702:Filoviridae Infections / Q000276:immunology / Q000517:prevention & control*; D016679:Genome, Viral; D019142:Hemorrhagic Fever, Ebola / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007109:Immunity / Q000276:immunology; D008379:Marburg Virus Disease / Q000276:immunology; D029024:Marburgvirus / Q000235:genetics / Q000276:immunology; D014611:Vaccination / Q000379:methods; D019444:Vaccines, DNA / Q000276:immunology / Q000627:therapeutic use; D014616:Vaccinia virus / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology / Q000627:therapeutic use*
D019444:Vaccines, DNA; D014764:Viral Proteins; D014765:Viral Vaccines