title: Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice.
abstract: From the age of 3 months until their natural deaths, female Swiss-derived SHR mice were subcutaneously injected 5 consecutive days every month with 0.1 ml of normal saline (control) or with 2.5 microg/mouse (approximately 100 microg/kg) of delta-sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) as the preparation Deltaran solved in 0.1 ml of saline. There were 54 mice in each group. The results of this study show that the treatment with Deltaran did not influence food consumption, but decreased the body weight of mice; it slowed down the age-related switching-off of estrous function; it decreased by 22.6% the frequency of chromosome aberrations in bone marrow cells; it did not influence mean life span; and it increased by 17.1% life span of the last 10% of the survivors and by 24.1% maximum life span in comparison with the control group. We also found that treatment with Deltaran significantly decreased total spontaneous tumor incidence (by 2.6-fold), mainly mammary carcinomas and leukemias in mice as compared with the control group. This is the first report on geroprotector and anticarcinogenic effect of DSIP-containing preparation Deltaran.
authors.affiliation: Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, Pesochny-2, St. Petersburg 197758, Russia.
authors.forename: Irina G
authors.initials: IG
authors.lastname: Popovich
authors.forename: Boris O
authors.initials: BO
authors.lastname: Voitenkov
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Anisimov
authors.forename: Vadim T
authors.initials: VT
authors.lastname: Ivanov
authors.forename: Inessa I
authors.initials: II
authors.lastname: Mikhaleva
authors.forename: Mark A
authors.initials: MA
authors.lastname: Zabezhinski
authors.forename: Irina N
authors.initials: IN
authors.lastname: Alimova
authors.forename: Dmitri A
authors.initials: DA
authors.lastname: Baturin
authors.forename: Natalia Yu
authors.initials: NY
authors.lastname: Zavarzina
authors.forename: Svetlana V
authors.initials: SV
authors.lastname: Rosenfeld
authors.forename: Anna V
authors.initials: AV
authors.lastname: Semenchenko
authors.forename: Anatoli I
authors.initials: AI
authors.lastname: Yashin
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D015415:Biomarkers; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D015994:Incidence; D007938:Leukemia / Q000453:epidemiology; D008136:Longevity / Q000187:drug effects*; D015674:Mammary Neoplasms, Animal / Q000453:epidemiology*; D051379:Mice; D008815:Mice, Inbred Strains; D015233:Models, Statistical; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D003701:Delta Sleep-Inducing Peptide