Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. II. Isolation, characterization, and structure determination.
A new group of thiazolyl peptide antibiotics, the nocathiacins, was isolated from cultured broth of Nocardia sp. The major analogs nocathiacins I-III (1-3) were purified using silica gel and Sephadex LH-20 chromatography techniques. The structures of nocathiacins I-III were determined by spectroscopic (2D-NMR, MSn) methods, and share structural similarities to glycothiohexide-alpha (4).
Leet
John E
JE
Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA. leetj@bms.com
Li
Wenying
W
Ax
Helen A
HA
Matson
James A
JA
Huang
Stella
S
Huang
Ron
R
Cantone
Joseph L
JL
Drexler
Dieter
D
Dalterio
Richard A
RA
Lam
Kin S
KS
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification*; D002850:Chromatography, Gel; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009615:Nocardia / Q000737:chemistry*; D010455:Peptides; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D010455:Peptides