Complete remission induced by G-CSF in a patient with acute myeloid leukemia with t(8;21)(q22;q22).
We describe a case of acute myeloid leukemia (AML) with t(8;21) in which complete remission (CR) was obtained with G-CSF given at 10 microg/kg in the absence of concomitant cytotoxic chemotherapy. CR was achieved following 2 weeks of therapy and confirmed by investigating minimal residual disease by four-color flow cytometry analysis. During treatment with G-CSF, maturing cells with cytoplasmic Auer Rods were observed in the peripheral blood, suggesting a differentiation effect. This case adds further evidence for a specific role of G-CSF in the treatment of AML with t(8;21), namely in patients who are not eligible for aggressive chemotherapy.
Ferrara
Felicetto
F
Division of Hematology, Cardarelli General Hospital, Via Niccoló Piccinni 6, Naples 80128, Italy. felicettoferrara@katamail.com
Schiavone
Ettore Mariano
EM
Palmieri
Salvatore
S
Mele
Giuseppina
G
Pocali
Barbara
B
Scalia
Giulia
G
Morabito
Paolo
P
Sebastio
Lucia
L
Del Vecchio
Luigi
L
D000208:Acute Disease; D001853:Bone Marrow / Q000473:pathology; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D005434:Flow Cytometry; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D016130:Immunophenotyping; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques; D012074:Remission Induction; D016879:Salvage Therapy; D014178:Translocation, Genetic; D016896:Treatment Outcome
D016179:Granulocyte Colony-Stimulating Factor