Site-selective iodine-magnesium exchange reaction of 1,4-diiodo-1,3-alkadienes by an organomagnesium ate complex, and its application to synthesis of polysubstituted styrenes and phenols.
When 1,4-diiodo-1,3-alkadienes were treated with i-PrBu2MgLi, highly site-selective iodine-magnesium exchange reaction took place to afford, after the reaction with electrophiles, a variety of 1-iodo-1,3-alkadiene derivatives. Synthetic utility of the reaction was demonstrated by an efficient preparation of polysubstituted styrenes and phenols.
Fukuhara
Kohki
K
Department of Biomolecular Engineering, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.
Takayama
Yuuki
Y
Sato
Fumie
F