title: Idiopathic hypereosinophilic syndrome associated with cutaneous infarction and deep venous thrombosis.
abstract: We report a case of idiopathic hypereosinophilic syndrome (HES) presenting with cutaneous infarction and subsequent extensive deep vein thrombosis. The eosinophilia improved dramatically with systemic corticosteroid therapy. A variety of skin disorders have been associated with HES, although there are no previous reports of HES associated with cutaneous infarction. HES is a rare disorder characterized by a sustained overproduction of eosinophils and multisystem disease. The aetiology of the eosinophilia remains uncertain but clonal populations of abnormal T-cells producing interleukin 5 may be implicated.
authors.affiliation: Department of Dermatology, Bristol Royal Infirmary, Bristol, UK. shalini@snarayan.fsnet.co.uk
authors.forename: S
authors.initials: S
authors.lastname: Narayan
authors.forename: F
authors.initials: F
authors.lastname: Ezughah
authors.forename: G R
authors.initials: GR
authors.lastname: Standen
authors.forename: J
authors.initials: J
authors.lastname: Pawade
authors.forename: C T C
authors.initials: CT
authors.lastname: Kennedy
mesh_terms: D000328:Adult; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D007238:Infarction / Q000175:diagnosis*; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D012867:Skin / Q000098:blood supply*; D020246:Venous Thrombosis / Q000175:diagnosis*
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone