title: [Virilism during pregnancy].
abstract: We discuss the causes of virilism in pregnancy and the impact of hyperandrogeny on the female foetus. We report a case of virilism in a 28-year-old, gravida 1, para 1 patient with normal pregnancy and review the literature. After conception, the patient had been well until the 18th week of gestation, when she developed signs of virilization; her serum testosterone was markedly elevated. She delivered of a normal male infant at term. After delivery, signs of virilization regressed with normalization of testosterone level but a wide mass of the left ovary that persisted for 8 months. The histological study of the tumor showed luteinized thecoma. Luteomas and hyper-reactio luteinalis were the principal causes of virilism in pregnancy, thecomas are rare.
authors.affiliation: Service de Néphrologie et de Médecine Interne, Hôpital Charles Nicolle, Tunis, Tunisie.
authors.forename: K
authors.initials: K
authors.lastname: Khiari
authors.forename: N
authors.initials: N
authors.lastname: Ben Abdallah
authors.forename: H
authors.initials: H
authors.lastname: Cheikhrouhou
authors.forename: L
authors.initials: L
authors.lastname: Cherif
authors.forename: I
authors.initials: I
authors.lastname: Hadj-Ali
authors.forename: H
authors.initials: H
authors.lastname: Ben Maïz
authors.forename: K
authors.initials: K
authors.lastname: Tarres
authors.forename: L
authors.initials: L
authors.lastname: Chachia
authors.forename: A
authors.initials: A
authors.lastname: Koubaa
authors.forename: N
authors.initials: N
authors.lastname: Kourda
authors.forename: S
authors.initials: S
authors.lastname: Ben Jilani
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000097:blood; D013739:Testosterone / Q000097:blood; D013798:Thecoma / Q000097:blood / Q000473:pathology*; D014770:Virilism / Q000175:diagnosis*
chemical_list: D013739:Testosterone