[Application of beta-cyclodextrin inclusion technique in new dosage form of angelica sinensis essential oil].
OBJECTIVE
To make a solid form of Angelica Sinensis essential oil by preparing its inclusion compound with beta-cyclodextrin and evaluate the inclusion rate, dissolution rate and liberating rate of this complex.


METHODS
GC-MS, X-ray diffraction and thin-layer chromatography were applied to characterize the essential oil and the inclusion compound.


RESULTS
The inclusion compound was shown to form a new phase by X-ray diffraction analysis. GC-MS and TLC check-up corroborated the composition of the free oil and the inclusion oil remaining the same.


CONCLUSIONS
The results showed Angelica Sinensis essential oil was more stable with beta-cyclodextrin inclusion. The preparation of this inclusion compound has advantages in limited amount, long time effect, easily preserved and convenient administration as a new dosage form.
Zhou
Chang-xin
CX
Department of Traditional Chinese Medicine and Natural Drugs Research, School of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, Zhejiang, China. C.X.Zhou@zju.edu.cn
Zou
Jian-kai
JK
Zhao
Yu
Y
Chen
Yao-zu
YZ
D029971:Angelica sinensis / Q000737:chemistry; D003505:Cyclodextrins; D004304:Dosage Forms; D004337:Drug Carriers; D004355:Drug Stability; D009822:Oils, Volatile / Q000008:administration & dosage* / Q000032:analysis / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D004304:Dosage Forms; D004337:Drug Carriers; D009822:Oils, Volatile; D047392:beta-Cyclodextrins; C031215:betadex