title: Localized epidural and bone amyloidosis, rare cause of paraplegia in multiple myeloma.
abstract: We report two cases of spinal cord compression by AL amyloid deposits in the setting of multiple myeloma. The first patient, a 57 year old man, had a surgical procedure late in his course, when his neurological status worsened despite medical treatment. The second patient, a 61 year old man, had surgical treatment as soon as vertebral body collapse and epiduritis were diagnosed and spinal amyloidosis revealed a non secretory myeloma. Neurological recovery was significant in both cases and neither developed manifestations of systemic amyloidosis 4 years later.
authors.affiliation: Department of Adult Medicine, Centre hospitalier universitaire, 16 Boulevard de Bulgarie, 35203 Rennes, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Laurat
authors.forename: Claire
authors.initials: C
authors.lastname: Cazalets
authors.forename: Martine
authors.initials: M
authors.lastname: Sébillot
authors.forename: Marc
authors.initials: M
authors.lastname: Bernard
authors.forename: Sylvie
authors.initials: S
authors.lastname: Caulet-Maugendre
authors.forename: Bernard
authors.initials: B
authors.lastname: Grosbois
mesh_terms: D000686:Amyloidosis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D001842:Bone and Bones / Q000473:pathology*; D004824:Epidural Space / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D010264:Paraplegia / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D013117:Spinal Cord Compression / Q000209:etiology* / Q000473:pathology* / Q000601:surgery; D013904:Thoracic Vertebrae