title: Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan.
abstract: Duplicate hospital diet samples obtained over 1 week in 2001 were analysed to estimate the daily intake of plasticizers and the results were compared with those obtained in 1999. The plasticizers quantified in this study were: dibutyl phthalate, butylbenzyl phthalate (BBP), di(2-ethylhexyl) phthalate (DEHP), diisononyl phthalate (DINP), di(2-ethylhexyl) adipate (DEHA), diisononyl adipate (DINA) and O-acetyl tributyl citrate (ATBC). Dipropyl, dipentyl, dihexyl and dicyclohexyl phthalate were also analysed but not detected. The analytical procedure for this follow-up study was essentially the same as in the previous one. Detection limits were 0.1-15.6 ng g(-1) for each plasticizer. One-week duplicate diet samples provided by three hospitals in three remote prefectures of Japan were analysed as individual meals. DEHP was detected at 6-675 ng g(-1) in 62 of 63 meals, significantly lower levels compared with those detected in 1999. Levels of DEHA and DINP also decreased. The mean intake of plasticizers estimated from all samples was 160 microg DEHP day(-1), 12.5 microg DEHA day(-1), 4.7 microg DINP day(-1) and 3.4 microg BBP day(-1). Levels of DINA were relatively high in meals from one hospital: in those meals, the average daily intake was 1338 microg day(-1). Those of ATBC were also higher in meals from another hospital: the average daily intake was 1228 microg day(-1). The sources of DINA and ATBC can be cling-film or sausage packaging.
authors.affiliation: National Institute of Health Sciences, Osaka Branch, 1-1-43 Hoenzaka, Chuo-ku, Osaka, 540-0006 Japan. tsumura@nihs.go.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Tsumura
authors.forename: S
authors.initials: S
authors.lastname: Ishimitsu
authors.forename: I
authors.initials: I
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Sakai
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuchida
authors.forename: Y
authors.initials: Y
authors.lastname: Tonogai
mesh_terms: D000272:Adipates / Q000032:analysis; D002274:Carcinogens, Environmental / Q000008:administration & dosage* / Q000032:analysis; D002951:Citrates / Q000032:analysis; D003993:Dibutyl Phthalate / Q000032:analysis; D004051:Diethylhexyl Phthalate / Q000032:analysis; D005506:Food Contamination / Q000032:analysis*; D005513:Food Inspection / Q000379:methods; D005521:Food Service, Hospital; D008401:Gas Chromatography-Mass Spectrometry; D017575:Gloves, Protective / Q000592:standards*; D006801:Humans; D010795:Phthalic Acids / Q000032:analysis; D010968:Plasticizers / Q000008:administration & dosage* / Q000032:analysis
chemical_list: D000272:Adipates; D002274:Carcinogens, Environmental; D002951:Citrates; D010795:Phthalic Acids; D010968:Plasticizers; C014953:2-acetyltributylcitrate; D003993:Dibutyl Phthalate; C013966:dioctyl adipate; C012125:diisononyl phthalate; C050775:diisononyl adipate; D004051:Diethylhexyl Phthalate; C027561:butylbenzyl phthalate