title: Serum levels of soluble CD30 in adult patients affected by atopic dermatitis and its relation to age, duration of disease and Scoring Atopic Dermatitis index.
abstract: The value of CD30 and the soluble circulating fragment of CD30 (sCD30) for atopic dermatitis (AD) remains unclear. In particular, little is known about the effects of age, duration of disease and Scoring Atopic Dermatitis index (SCORAD) on the levels of serum sCD30 in patients affected by AD. In the present study, we have analysed serum sCD30 levels of adult patients affected by AD. The study's population includes 18 non-smoking outpatients, with a diagnosis of AD. As a control group we studied 18 non-atopic subjects from laboratory staff, matched for sex and age. These subjects had no history of AD, urticaria or seasonal or perennial rhinitis or asthma, and had negative skin prick test to a panel of allergens. The sCD30 serum levels were clearly higher in patients affected by AD (14.2+/-9.0 IU/ml) than in healthy subjects (1.2+/-0.8 IU/ml) (p<0.001). No differences were observed between males and females affected by atopic dermatitis, regarding age, duration of disease and SCORAD. Significant correlations were found between serum levels of sCD30 levels and age (r=-0.55; 95% confidence interval (CI) for r (Fisher's z transformed)=-0.81 to -0.12; p=0.01), duration of the disease (months) (r=-0.64; 95% CI for r (Fisher's z transformed)=-0.85 to -0.24; p=0.004) and SCORAD (r=-0.74; 95% CI for r (Fisher's z transformed)=-0.89 to -0.42; p=0.004). As demonstrated by the close correlation with age, duration of disease and SCORAD, serum levels of sCD30 appear to be an additional marker for the follow-up of AD.
authors.affiliation: Dipartimento di Medicina Clinica e delle Patologie Emergenti, Università degli Studi di Palermo, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Di Lorenzo
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Gangemi
authors.forename: Rosaria Alba
authors.initials: RA
authors.lastname: Merendino
authors.forename: Paola Lucia
authors.initials: PL
authors.lastname: Minciullo
authors.forename: Serafina Paola
authors.initials: SP
authors.lastname: Cannavò
authors.forename: Nicola
authors.initials: N
authors.lastname: Martinelli
authors.forename: Pasquale
authors.initials: P
authors.lastname: Mansueto
authors.forename: Giovanni Battista
authors.initials: GB
authors.lastname: Rini
authors.forename: Roberto
authors.initials: R
authors.lastname: Corrocher
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Pacor
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015415:Biomarkers; D003876:Dermatitis, Atopic / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood*; D008297:Male; D012720:Severity of Illness Index; D012995:Solubility
chemical_list: D015415:Biomarkers; D017730:Ki-1 Antigen