title: [Some remarks on the management of liver donor].
abstract: We evaluated 481 liver donors in order to assess the incidence of positive cultures on samples obtained before harvesting, at harvesting and on preservation fluid; to determine factors related to positive cultures in the donor; to analyse the bacterial and fungal transmission from donor to recipient; to verify the influence of donor culture positivity on graft and patient survival. Cultures were positive in 232 of 481 (48%) donors. Bacteremia was present in 101 of 481 (20%) donors. Intensive care length of stay was significantly longer in culture-positive donors. A Gram-negative bacteria transmission from the infected donor to the graft recipient was proven in 1 case. No differences in 1-year survival and retransplantation rates were found between patients receiving livers from culture-positive or negative donors. In conclusion, even if rare, donor to host infection transmission is proven. Extended criteria for organ procurement may explain the high number of culture-positive donors we report. Careful microbiological surveillance and treatment can reduce the clinical negative impact on recipient outcome.
authors.affiliation: Anestesia e Rianimazione 6, Azienda Ospedaliera S. Giovanni Battista, Torino, Italy. ecerutti@molinette.piemonte.it
authors.forename: E
authors.initials: E
authors.lastname: Cerutti
authors.forename: C
authors.initials: C
authors.lastname: Stratta
authors.forename: M M
authors.initials: MM
authors.lastname: Schellino
authors.forename: R
authors.initials: R
authors.lastname: Serra
authors.forename: F
authors.initials: F
authors.lastname: Fop
authors.forename: F
authors.initials: F
authors.lastname: Lupo
authors.forename: M
authors.initials: M
authors.lastname: Salizzoni
mesh_terms: D006801:Humans; D007239:Infections / Q000635:transmission*; D008099:Liver / Q000382:microbiology*; D016031:Liver Transplantation; D019520:Living Donors; D012189:Retrospective Studies