title: Propagating fronts, chaos and multistability in a cell replication model.
abstract: Numerical solutions to a model equation that describes cell population dynamics are presented and analyzed. A distinctive feature of the model equation (a hyperbolic partial differential equation) is the presence of delayed arguments in the time (t) and maturation (x) variables due to the nonzero length of the cell cycle. This transport like equation balances a linear convection with a nonlinear, nonlocal, and delayed reaction term. The linear convection term acts to impress the value of u(t,x=0) on the entire population while the death term acts to drive the population to extinction. The rich phenomenology of solution behaviour presented here arises from the nonlinear, nonlocal birth term. The existence of this kinetic nonlinearity accounts for the existence and propagation of soliton-like or front solutions, while the increasing effect of nonlocality and temporal delays acts to produce a fine periodic structure on the trailing part of the front. This nonlinear, nonlocal, and delayed kinetic term is also shown to be responsible for the existence of a Hopf bifurcation and subsequent period doublings to apparent "chaos" along the characteristics of this hyperbolic partial differential equation. In the time maturation plane, the combined effects of nonlinearity, nonlocality, and delays leads to solution behaviour exhibiting spatial chaos for certain parameter values. Although analytic results are not available for the system we have studied, consistency and validation of the numerical results was achieved by using different numerical methods. A general conclusion of this work, of interest for the understanding of any biological system modeled by a hyperbolic delayed partial differential equation, is that increasing the spatio-temporal delays will often lead to spatial complexity and irregular wave propagation. (c) 1996 American Institute of Physics.
authors.affiliation: Department of Applied Mathematics, University of Washington, Seattle, Washington 98195Center for Nonlinear Dynamics and Departments of Physiology, Physics, and Mathematics, McGill University, 3655 Drummond, Room 1124, Montreal, Quebec, H3G 1Y6, CanadaDepartment of Chemical Engineering, McGill University, 3455 University Street, Montreal, Quebec, H3A 2A7, Canada.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Crabb
authors.forename: Michael C.
authors.initials: MC
authors.lastname: Mackey
authors.forename: Alejandro D.
authors.initials: AD
authors.lastname: Rey