Treatment of toxic epidermal necrolysis in AIDS with intravenous immunoglobulins.
Individuals with AIDS are at higher risk of developing severe cutaneous adverse drug reactions. We report two AIDS patients with drug-induced toxic epidermal necrolysis (TEN). The suspected drugs were discontinued. Both patients were treated with intravenous human immunoglobulins at a dose of 1 g/kg body weight per day for two consecutive days and both experienced a good outcome. Intravenous immunoglobulin potentially lowers the morbidity and mortality of TEN and shortens the duration of the patient's hospitalization.
Tan
A
A
National Skin Centre, Singapore. audreytan@nsc.gov.sg
Tan
H H
HH
Lee
C C
CC
Ng
S K
SK
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000209:etiology / Q000473:pathology / Q000628:therapy*
D016756:Immunoglobulins, Intravenous