When ubiquitin meets ubiquitin receptors: a signalling connection.
Ubiquitylation is emerging as a versatile device for controlling cellular functions. Here, we propose that monoubiquitylation is rapidly induced by signalling events and allows the establishment of protein-protein interactions between monoubiquitylated proteins and partners that contain distinct ubiquitin-binding domains. We also put forward speculative models for the regulation of monoubiquitylation versus polyubiquitylation.
Di Fiore
Pier Paolo
PP
Istituto Europeo di Oncologia, Via Ripamonti 435, 20141, Milan, Italy. pdifiore@ieo.it
Polo
Simona
S
Hofmann
Kay
K
D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D011992:Endosomes / Q000502:physiology; D005199:Fanconi Anemia / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D025801:Ubiquitin / Q000378:metabolism*
D002352:Carrier Proteins; D025801:Ubiquitin