title: Systematic phylogenomic evidence of en bloc duplication of the ancestral 8p11.21-8p21.3-like region.
abstract: The genomes of many higher organisms, including plants and bony fish, frequently undergo polyploidization, and it has long been hypothesized that these, and other, large-scale genomic duplications have played an important role in the major evolutionary transitions of our past. Here we build upon an early work to show that the human genomic region 8p11.21-8p21.3 has three paralogous regions on chromosomes 4, 5, and 10 that were produced by two rounds of duplications after the protostomian-deuterostomian split and before the actinopterygian-sarcopterygian split. We base our analysis on the phylogenetic reconstruction of the evolutionary history of 38 gene families located in these regions. Using an alignment centered on protein domains, three different phylogenetic methods, and divergence time estimation, this analysis gives more support in favor of two ancient polyploidization events in the vertebrate ancestral genome.
authors.affiliation: EA Biodiversité 2202, Université de Provence, Marseille, France. avienne@up.univ-mrs.fr
authors.forename: Alexandre
authors.initials: A
authors.lastname: Vienne
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Rasmussen
authors.forename: Laurent
authors.initials: L
authors.lastname: Abi-Rached
authors.forename: Pierre
authors.initials: P
authors.lastname: Pontarotti
authors.forename: André
authors.initials: A
authors.lastname: Gilles
mesh_terms: D000818:Animals; D002816:Chordata, Nonvertebrate / Q000235:genetics / Q000276:immunology; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D019143:Evolution, Molecular; D020440:Gene Duplication; D015894:Genome, Human; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D014714:Vertebrates / Q000235:genetics* / Q000276:immunology