[Content of lipid peroxidation products, alpha-tocopherol and ceruloplasmin in the blood of patients with vascular complications of insulin-dependent diabetes mellitus].
The content of lipid peroxidation products (LPP), as well as the concentrations of alpha-tocopherol (alpha-TC) and of ceruloplasmin (CP) were examined in the blood serum of patients with insulin-dependent diabetes mellitus (IDDM) without any vascular complications and with diabetic micro- and macroangiopathies. It was established that IDDM is accompanied by an accumulation of LPPs and a reduction of alpha-TC in the blood serum. The development of microangiopathies leads to a relative limitation of LPP, still, the intensity of the process exceeds the normal value. If macroangiopathies are available additionally, this aggravates the deficit of endogenous antioxidants due to an extra reduced concentration of the circulating alpha-TC and a simultaneously decreased CP level.
Volchegorskiĭ
I A
IA
Kharchenkova
N V
NV
D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D002570:Ceruloplasmin / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications*; D003925:Diabetic Angiopathies / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D024502:alpha-Tocopherol / Q000097:blood*
D000975:Antioxidants; D002570:Ceruloplasmin; D024502:alpha-Tocopherol