title: Herpes simplex virus latency-associated transcript gene function.
abstract: A major area of interest in the study of herpes simplex virus type 1 (HSV-1) involves the persistence of the virus within a latent state in neuronal cells of infected humans. The latency-associated transcripts (LATs) are believed to play a key role during HSV-1 latency. This review will discuss the most recent findings on the involvement of the LAT region with apoptotic pathways and how this relates to other potential functions of the LATs.
authors.affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076, USA.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Kent
authors.forename: Wen
authors.initials: W
authors.lastname: Kang
authors.forename: Cathie G
authors.initials: CG
authors.lastname: Miller
authors.forename: Nigel W
authors.initials: NW
authors.lastname: Fraser
mesh_terms: D000818:Animals; D017209:Apoptosis; D015967:Gene Expression Regulation, Viral; D005807:Genes, Overlapping; D005814:Genes, Viral; D018259:Herpesvirus 1, Human / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics; D051379:Mice; D009474:Neurons / Q000473:pathology / Q000821:virology; D012367:RNA, Viral / Q000235:genetics*; D011817:Rabbits; D014158:Transcription, Genetic; D017735:Virus Latency / Q000235:genetics*
chemical_list: D012367:RNA, Viral