[Effect of shen-dong-xin-bao oral liquid on IFN-induction and NK cell activity in CVB3m infected mice].
OBJECTIVE
Our aim was to investigate the effect of Shen-dong-xin-bao oral liquid on IFN-induction and NK cell activity in mice with coxsackie virus B3(CVB3m) infection in different infective stages.


METHODS
The level of serum interferon (IFN) and the activity of natural killer (NK) cells in CVB3m induced myocarditis in mice were determined. Natural killer cell cytolytic activity was tested by MTT method and interferon titers by 50% microcytopathic effect assay.


RESULTS
In the infected mice fed with 30 g/kg or 12 g/kg per day of Shen-dong-xin-bao oral administration for 10d and 20d, the mean titers of IFN were markedly higher than that in untreated infected group, P < 0.05. The NK cell activity in treated infected groups was also prominently higher than that in untreated infected group, especially on 20d, P < 0.05.


CONCLUSIONS
This results demonstrate that administration of Shen-dong-xin-bao oral liquid possesses enhancement of antiviral immunocompetent action.
Wan
S
S
Guang An Men Hospital & Chinese Academy of Traditional Chinese Medicine, 100053.
Li
J
J
Chen
H
H
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D003384:Coxsackievirus Infections / Q000188:drug therapy* / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D007372:Interferons / Q000097:blood*; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D009205:Myocarditis / Q000188:drug therapy* / Q000276:immunology / Q000821:virology
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D007372:Interferons