Transgenics at breaking-point.
In this issue of Cancer Cell, Forster et al. (2003) have generated mice that recapitulate both the mechanism (sporadic somatic translocation) and the consequences (expression of two translocation fusion genes) leading to an accurate leukemia model.
Prosser
Haydn
H
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.
Bradley
Allan
A
D000818:Animals; D018076:DNA, Complementary / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D019426:Integrases; D007938:Leukemia / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D008957:Models, Genetic; D014178:Translocation, Genetic; D014764:Viral Proteins
D018076:DNA, Complementary; D014764:Viral Proteins; C045073:Cre recombinase; D019426:Integrases