title: Highly efficient rhodium/monodentate phosphoramidite catalyst and its application in the enantioselective hydrogenation of enamides and alpha-dehydroamino acid derivatives.
abstract: An easily prepared and highly efficient monodentate phosphoramidite ligand derived from BINOL, (S)-2,2'-O,O-(1,1'-binaphthyl)-dioxo-N,N-diethylphospholidine, was examined in the hydrogenation of both enamides and alpha-dehydroamino acid derivatives. The catalyst provided remarkably high enantioselectivities (up to 99.6% ee for enamides and >99.9% ee for alpha-dehydroamino acid derivatives).
authors.affiliation: The Hong Kong Polytechnic University, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Jia
authors.forename: Xingshu
authors.initials: X
authors.lastname: Li
authors.forename: Lijin
authors.initials: L
authors.lastname: Xu
authors.forename: Qian
authors.initials: Q
authors.lastname: Shi
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Yao
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan