Statins and oxidative stress during atherogenesis.
Oxidised low-density lipoprotein (LDL) is believed to be the most atherogenic form of LDL. However, while a number of experimental data support this concept, the protective role of antioxidants that may prevent LDL oxidation in atherosclerosis is only partially confirmed by studies in man. Observational and epidemiological data as well as randomised trials failed to provide clear-cut indications, because of mixed results on the protective role of antioxidants against cardiovascular diseases. In spite of the lack of a general consensus, recent data reinforce the concept that a regular intake of antioxidants present in food blocks the progression of atherosclerosis and that the reduced ability of LDL to oxidise may represent a good marker to follow the action of antioxidants. Among their properties statins also possess antioxidant activities and the aim of this paper is to review the scientific evidence for such an effect and its possible clinical relevance.
Norata
Giuseppe D
GD
Department of Pharmacological Sciences, University of Milan, and Centro per lo Studio e la Prevenzione delle Vasculopatie Periferiche, Ospedale Bassini, Italy.
Pirillo
Angelo
A
Catapano
Alberico L
AL
D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control*; D008078:Cholesterol, LDL / Q000009:adverse effects / Q000187:drug effects / Q000502:physiology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D066298:In Vitro Techniques; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology*
D000975:Antioxidants; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors