[Study on sober-up effect of crystal sugar-vinegar solution].
OBJECTIVE
To investigate the enhancing effect of crystal sugar-vinegar solution on the tolerance of alcohol consumption in mice and rabbits.


METHODS
Crystal sugar-vinegar solution was given to mice or rabbits 30 min before feeding a dose of alcohol. The toxic behavior and percentage of animal death in 24 hours were observed. Meanwhile, blood alcohol levels in the rabbits were measured.


RESULTS
Crystal sugar-vinegar solution could prolong the latent period of righting reflex disappearing of the drunk mice(P < 0.01) and decrease death percentage of drunk mice in 24 hours(P < 0.01). Crystal sugar-vinegar could also decrease blood alcohol levels in the drunk rabbits, especially 30 min(P < 0.01) and 180 min(P < 0.05) after administration of alcohol.


CONCLUSIONS
Crystal sugar-vinegar solution has an evident sober-up effect on drunk model animal.
Xu
Qing
Q
Department of Pharmacology, Guilin Medical College, Guilin 541001, Guangxi, China. XuQingdegg0247@sina.com
Wei
Yu-xian
YX
Tang
Zhu-nian
ZN
Gan
Li-Qiong
LQ
Hunag
Zo-yun
ZY
D019342:Acetic Acid / Q000627:therapeutic use*; D000435:Alcoholic Intoxication / Q000097:blood / Q000188:drug therapy*; D000437:Alcoholism / Q000097:blood / Q000188:drug therapy*; D000438:Alcohols / Q000097:blood; D000818:Animals; D002241:Carbohydrates / Q000737:chemistry / Q000627:therapeutic use*; D003460:Crystallization; D004338:Drug Combinations; D005260:Female; D008297:Male; D051379:Mice; D011817:Rabbits
D000438:Alcohols; D002241:Carbohydrates; D004338:Drug Combinations; D019342:Acetic Acid