Implications of enzyme kinetics.
Of the many examples of oscillatory kinetic behaviour known, several are briefly reviewed, including those of glycolysis, the peroxidase-oxidase reaction and oscillations in cellular calcium concentration. It is shown that simple mathematical models employing allosteric rate laws are sufficient to explain the instability of the steady state and the appearance of sustained oscillations. The cAMP-signalling systems of cellular slime moulds and the dynamics of intracellular calcium oscillations illustrate the importance of such oscillophores to inter- and intra-cellular communication and differentiation.
McDonald
A G
AG
Department of Biochemistry, Trinity College, Dublin 2, Republic of Ireland. amcdonld@tcd.ie
D000818:Animals; D004023:Dictyostelium / Q000201:enzymology / Q000254:growth & development; D004798:Enzymes / Q000378:metabolism*; D006019:Glycolysis; D006706:Homeostasis; D007700:Kinetics; D008018:Life Cycle Stages
D004798:Enzymes