Gene expression of type I collagen in neoplastic chondrocytes.
In the present examination, we detected type I collagen mRNA in neoplastic chondrocytes in osteochondromas, typical benign bone neoplasms. We believe that the cells involved in >chondroid bone< appearing in osteochondromas temporally express cartilage phenotypes and then change directly into bone-forming cells that survive in the >chondroid bone< until the tissue is resorbed and remodelled into true bone tissue.
Kimura
A
A
Department of Oral Pathology, Matsumoto Dental University, School of Dentistry, Shiojiri, Japan.
Kawakami
Toshiyuki
T
Matsuura
S
S
Hasegawa
H
H
Kanda
H
H
Tujigiwa
H
H
Nagatsuka
H
H
Nagai
N
N
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D019902:Chondrocytes / Q000378:metabolism / Q000473:pathology; D024042:Collagen Type I / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D015831:Osteochondroma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism
D024042:Collagen Type I; D012333:RNA, Messenger; D012334:RNA, Neoplasm