title: Effects of twice daily application of 2% dorzolamide on intraocular pressure in normal cats.
abstract: The effect of the topical carbonic anhydrase inhibitor, dorzolamide, on intraocular pressure in cats was studied. The intraocular pressure of both eyes of eight healthy cats was measured using applanation tonometery (Tono-Pen) during two phases: control and treatment. Both eyes were treated with 2% dorzolamide twice a day during the treatment phase. Application of dorzolamide resulted in a significant decrease of intraocular pressure over the treatment phase. By the fourth and fifth day of treatment, the mean intraocular pressure (+/- standard deviation) was 9.7 (+/- 1.5) mmHg, whereas the mean (+/- standard deviation) for the last 2 days of the control period was 12.2 (+/- 2.0) mmHg. Based on this study, dorzolamide is a potentially effective treatment for glaucoma in cats, significantly lowering intraocular pressure.
authors.affiliation: Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blackburg 24061, USA. mrainbow@vt.edu
authors.forename: Marc E
authors.initials: ME
authors.lastname: Rainbow
authors.forename: Joan
authors.initials: J
authors.lastname: Dziezyc
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D002415:Cats / Q000502:physiology*; D005260:Female; D007429:Intraocular Pressure / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009883:Ophthalmic Solutions; D012016:Reference Values; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology*; D013876:Thiophenes / Q000008:administration & dosage / Q000494:pharmacology*; D014065:Tonometry, Ocular / Q000662:veterinary
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D009883:Ophthalmic Solutions; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide