title: Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues.
abstract: Three new endocannabinoid analogues in which amide moiety was replaced either by oxomethylene group or ester moiety with simultaneous substitution of both alpha-hydrogens with methyl groups were synthesized and their abilities to interact with CB1-receptor and FAAH were investigated.
authors.affiliation: UMR CNRS 5074, Faculté de Pharmacie, 15 av. C. Flahault, BP 14491, F-34093 5, Montpellier Cedex, France. balas@pharma.univ-montpl.fr
authors.forename: Siham
authors.initials: S
authors.lastname: El Fangour
authors.forename: Laurence
authors.initials: L
authors.lastname: Balas
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Rossi
authors.forename: Andrey
authors.initials: A
authors.lastname: Fedenyuk
authors.forename: Natalia
authors.initials: N
authors.lastname: Gretskaya
authors.forename: Mikhail
authors.initials: M
authors.lastname: Bobrov
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bezuglov
authors.forename: Cecilia J
authors.initials: CJ
authors.lastname: Hillard
authors.forename: Thierry
authors.initials: T
authors.lastname: Durand
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors; D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D001667:Binding, Competitive; D063385:Cannabinoid Receptor Modulators / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D063388:Endocannabinoids; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D005026:Ethylene Glycols / Q000494:pharmacology; D053284:Polyunsaturated Alkamides; D011869:Radioligand Assay; D051381:Rats; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism; D000099252:Fatty Acid Amide Hydrolases
chemical_list: D000581:Amidohydrolases; D001095:Arachidonic Acids; D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D004791:Enzyme Inhibitors; D005026:Ethylene Glycols; D053284:Polyunsaturated Alkamides; D043884:Receptor, Cannabinoid, CB1; D000099252:Fatty Acid Amide Hydrolases; C114008:arachidonoylethylene glycol; C078814:anandamide