New unusual iridoids from the leaves of noni (Morinda citrifolia L.) show inhibitory effect on ultraviolet B-induced transcriptional activator protein-1 (AP-1) activity.
A novel iridoid dimer in whose structure the two iridoid units are connected by a rare ether group, together with two new unusual iridoids showing significant inhibition of UVB-induced Activator Protein-1 (AP-1) activity in cell cultures, have been isolated from the leaves of noni (Morinda citrifolia L.). Their structures were determined on the basis of detailed high-field 1D and 2D spectral analysis. Their inhibitory effect on UVB-induced transcriptional Activator Protein-1 (AP-1) activity are also discussed.
Sang
Shengmin
S
Department of Food Science and Center for Advanced Food Technology, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901-8520, USA. ssang@rci.rutgers.edu
Liu
Guangming
G
He
Kan
K
Zhu
Nanqun
N
Dong
Zigang
Z
Zheng
Qunyi
Q
Rosen
Robert T
RT
Ho
Chi-Tang
CT
D000818:Animals; D002460:Cell Line; D019281:Dimerization; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D032066:Morinda / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D018808:Transcription Factor AP-1 / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays
D039823:Iridoids; D018808:Transcription Factor AP-1