Ibuprofen and acetaminophen: effect on muscle inflammation after eccentric exercise.
OBJECTIVE
We examined the influence of ibuprofen and acetaminophen on muscle neutrophil and macrophage concentrations after novel eccentric contractions.


METHODS
Twenty-four males (25 +/- 3 yr) were divided into three groups that received the maximal over-the-counter dose of either ibuprofen (1200 mg x d-1), acetaminophen (4000 mg x d-1), or a placebo after eccentric contractions of the knee extensors. Biopsies from the vastus lateralis were taken before and 24 h after exercise. Inflammatory cells were quantified in muscle cross-sections using immunohistochemistry.


RESULTS
Macrophage concentrations were elevated by 1.5- to 2.5-fold (P < 0.05) at 24 h postexercise relative to preexercise concentrations, whereas neutrophil concentrations were not significantly elevated. Muscle inflammatory cell concentrations were unaffected by treatment with ibuprofen or acetaminophen when compared with placebo.


CONCLUSIONS
Maximal over-the-counter doses of ibuprofen or acetaminophen, when administered therapeutically, do not affect muscle concentrations of neutrophils or macrophages 24 h after a novel bout of eccentric contractions.
Peterson
Jennifer M
JM
The University of Toledo, Department of Kinesiology, OH 43606, USA.
Trappe
Todd A
TA
Mylona
Eleni
E
White
Faber
F
Lambert
Charles P
CP
Evans
William J
WJ
Pizza
Francis X
FX
D000082:Acetaminophen / Q000008:administration & dosage / Q000494:pharmacology*; D000284:Administration, Oral; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004311:Double-Blind Method; D015444:Exercise; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology*; D007249:Inflammation; D008264:Macrophages; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology*; D009504:Neutrophils
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D007052:Ibuprofen