title: Paucity of Sjogren-like syndrome in a cohort of HIV-1-positive patients in the HAART era. Part II.
abstract: OBJECTIVE
  This study was performed in order to investigate the prevalence of Sjögren-like syndrome (SLS) in the highly active anti-retroviral therapy (HAART) era in a cohort of HIV-1-positive Greek patients.
  
  
  METHODS
  One hundred and thirty-one unselected patients were screened by the validated European Union (EU) criteria for Sjögren's syndrome. Of the 31 who gave a positive EU-validated questionnaire, 17 consented to undergo minor salivary gland biopsy and other tests.
  
  
  RESULTS
  Only two patients had a positive salivary gland biopsy and both belonged to the non-compliant HAART group, whereas none of the compliant HAART patients had histological findings.
  
  
  CONCLUSIONS
  It is concluded that SLS, the prevalence of which in the pre-HAART era was 7.8%, has disappeared, possibly as a result of the protective action of HAART.
authors.affiliation: Academic Department of Pathophysiology, AIDS Unit, School of Medicine, National and Kapodistrian University of Athens, Greece.
authors.forename: G D
authors.initials: GD
authors.lastname: Panayiotakopoulos
authors.forename: K
authors.initials: K
authors.lastname: Aroni
authors.forename: D
authors.initials: D
authors.lastname: Kyriaki
authors.forename: S
authors.initials: S
authors.lastname: Paikos
authors.forename: N
authors.initials: N
authors.lastname: Vouyioukas
authors.forename: A
authors.initials: A
authors.lastname: Vlachos
authors.forename: A N
authors.initials: AN
authors.lastname: Kontos
authors.forename: T
authors.initials: T
authors.lastname: Kordossis
mesh_terms: D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D012470:Salivary Glands, Minor / Q000473:pathology; D012859:Sjogren's Syndrome / Q000473:pathology / Q000821:virology*
chemical_list: D019380:Anti-HIV Agents