title: Antidiabetic dimeric guianolides and a lignan glycoside from Lactuca indica.
abstract: Three novel sesquiterpene lactones, lactucain A (1), B (2), and C (3), and a new furofuran lignan, lactucaside (4), were isolated from Lactuca indica along with nine known compounds, 11beta,13-dihydrolactucin, cichoriosides B, quercetin, quercetin 3-O-glucoside, rutin, apigenin, luteolin, luteolin 7-O-glucuronide, and chlorogenic acid. Among these compounds, latucain C (3) and lactucaside (4) showed significant antidiabetic activity.
authors.affiliation: Department of Medicinal Chemistry, College of Pharmacy, Taipei Medical University, No. 250 Wu-Hsing Street, Taiwan 110, Republic of China.
authors.forename: Chia-Chung
authors.initials: CC
authors.lastname: Hou
authors.forename: Shwu-Jiuan
authors.initials: SJ
authors.lastname: Lin
authors.forename: Juei-Tang
authors.initials: JT
authors.lastname: Cheng
authors.forename: Feng-Lin
authors.initials: FL
authors.lastname: Hsu
mesh_terms: D000818:Animals; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides; D006868:Hydrolysis; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018545:Lactuca / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D013624:Taiwan
chemical_list: D005663:Furans; D006027:Glycosides; D007004:Hypoglycemic Agents; D007783:Lactones; D017705:Lignans; D012717:Sesquiterpenes; C478142:lactucain A; C478143:lactucain B; C478144:lactucain C; C478145:lactucaside