title: Diversity within the DRB1*08 allele family in four populations from a United States hematopoietic stem cell donor database and characterization of five novel DRB1*08 alleles.
abstract: The frequencies of DRB1*08 alleles within four major United States populations found within a hematopoietic stem cell volunteer donor database were determined by DNA sequencing of over 60 DRB1*08 positive individuals from each group. Seven of 30 known DRB1*08 alleles were identified within this study population (080101, 080201, 080302, 080401, 0806, 0807, and 0811). Each ethnic group was characterized by a different highly prevalent allele: DRB1*080101 in Caucasians; DRB1*080401 in African-Americans; DRB1*080302 in Asians; and DRB1*080201 in Hispanics. The alleles DRB1*080101, DRB1*080201, and DRB1*080401 were present in all four populations. This report also describes five novel DRB1*08 alleles uncovered during routine human leukocyte antigen typing.
authors.affiliation: Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Rizzuto
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Noriko
authors.initials: N
authors.lastname: Steiner
authors.forename: Rebecca
authors.initials: R
authors.lastname: Slack
authors.forename: Ting
authors.initials: T
authors.lastname: Tang
authors.forename: Uwe
authors.initials: U
authors.lastname: Heine
authors.forename: Yu Su
authors.initials: YS
authors.lastname: Lin
authors.forename: Jennifer
authors.initials: J
authors.lastname: Ng
authors.forename: RobertJ
authors.initials: R
authors.lastname: Hartzman
authors.forename: Carolyn Katovich
authors.initials: CK
authors.lastname: Hurley
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D014644:Genetic Variation; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006412:Hematopoietic Stem Cells; D006801:Humans; D017422:Sequence Analysis, DNA; D014019:Tissue Donors
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains