[Virilism during pregnancy].
We discuss the causes of virilism in pregnancy and the impact of hyperandrogeny on the female foetus. We report a case of virilism in a 28-year-old, gravida 1, para 1 patient with normal pregnancy and review the literature. After conception, the patient had been well until the 18th week of gestation, when she developed signs of virilization; her serum testosterone was markedly elevated. She delivered of a normal male infant at term. After delivery, signs of virilization regressed with normalization of testosterone level but a wide mass of the left ovary that persisted for 8 months. The histological study of the tumor showed luteinized thecoma. Luteomas and hyper-reactio luteinalis were the principal causes of virilism in pregnancy, thecomas are rare.
Khiari
K
K
Service de Néphrologie et de Médecine Interne, Hôpital Charles Nicolle, Tunis, Tunisie.
Ben Abdallah
N
N
Cheikhrouhou
H
H
Cherif
L
L
Hadj-Ali
I
I
Ben Maïz
H
H
Tarres
K
K
Chachia
L
L
Koubaa
A
A
Kourda
N
N
Ben Jilani
S
S
D000328:Adult; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000097:blood; D013739:Testosterone / Q000097:blood; D013798:Thecoma / Q000097:blood / Q000473:pathology*; D014770:Virilism / Q000175:diagnosis*
D013739:Testosterone