title: Taenia crassiceps cysticercosis: immune response in susceptible and resistant BALB/c mouse substrains.
abstract: Taenia crassiceps can naturally and experimentally infect rodents in which they reproduce by budding. Differences in the susceptibility to T. crassiceps cysticercosis were found between two BALB/c substrains: BALB/cAnN (susceptible) and BALB/cJ (resistant). In chimeric mice, resistance was transferred to susceptible mice with bone marrow cells from the resistant mice, which argues in favor of an immune mediation of the resistant phenotype. To further explore the immune response that could underlie these differences in susceptibility, the specific cellular immune response elicited by the parasite was explored in both substrains. An increased proliferative response and IL-2 levels were induced by cysticercal antigens only in splenocytes from resistant mice. A decrease in the percentage of CD4(+) (11.1%), CD8(+) (17.5%) was found in splenocytes from susceptible BALB/cAnN mice. A study of the TCRV beta repertoire revealed a significant decrease in V beta 2 in both CD4(+) and CD8(+) splenocytes only in the susceptible BALB/cAnN strain.
authors.affiliation: Department of Immunology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Apartado Postal 70-228, 04510 Mexico City, Mexico.
authors.forename: Sergio
authors.initials: S
authors.lastname: López-Briones
authors.forename: Edmundo
authors.initials: E
authors.lastname: Lamoyi
authors.forename: Gladis
authors.initials: G
authors.lastname: Fragoso
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Soloski
authors.forename: Edda
authors.initials: E
authors.lastname: Sciutto
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003551:Cysticercosis / Q000276:immunology* / Q000469:parasitology; D004198:Disease Susceptibility; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism; D013621:Taenia / Q000276:immunology / Q000472:pathogenicity*
chemical_list: D000947:Antigens, Helminth; D016693:Receptors, Antigen, T-Cell, alpha-beta