Host defences to Citrobacter rodentium.
Citrobacter rodentium is a natural non-invasive bacterial pathogen which infects the distal colon of mice. It uses the same molecular mechanisms of type III secretion as human enteropathogenic and enterohemorrhagic Escherichia coli to colonise the epithelial cells of the gut and is therefore an ideal model to study host-bacterial pathogen interactions in vivo. Infection elicits mucosal inflammation with similarities to inflammatory bowel disease, and so it is a readily accessible model to investigate the relationship between inflammation and anti-bacterial immunity in the gut.
MacDonald
Thomas T
TT
Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK. t.t.macdonald@soton.ac.uk
Frankel
Gad
G
Dougan
Gordon
G
Goncalves
Nathalie S
NS
Simmons
Cameron
C
D018829:Adhesins, Bacterial / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D016971:Citrobacter freundii / Q000276:immunology / Q000472:pathogenicity*; D003106:Colon / Q000473:pathology; D004195:Disease Models, Animal; D004756:Enterobacteriaceae Infections / Q000276:immunology*; D029968:Escherichia coli Proteins; D006801:Humans; D006965:Hyperplasia / Q000209:etiology; D018928:Immunity, Mucosal; D007249:Inflammation; D051379:Mice; D008810:Mice, Inbred C57BL
D018829:Adhesins, Bacterial; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; C073819:eaeA protein, E coli