[An association study of histocompatibility leukocyte antigen-class II with Meniere's disease].
OBJECTIVE
To investigate the relation between histocompatibility leukocyte antigen (HLA)-class II DRB1 and Meniére's disease in Chinese.


METHODS
Polymerase chain reaction-sequence specific primers (PCR-SSP) technique was used. HLA-class II allele distribution were measured in 60 patients with Meniére's disease, in comparison with those in 85 normal population.


RESULTS
The results showed that the frequency of DRB1*09 allele was significantly lower in Meniére's disease patients than in those of controls (relative risk = 0.17, P < 0.01).


CONCLUSIONS
HLA-DRB1*09 of the patients with Meniére's disease was significant low. It implied that DRB1*09 may be a protective gene for Meniére's disease.
Meng
X
X
Beijing Institute of Otorhinolaryngology, Beijing 100730, China.
Lian
N
N
Yang
Z
Z
Liu
C
C
Tang
L
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People; D016887:Cardiopulmonary Resuscitation; D002681:China / Q000453:epidemiology; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000235:genetics / Q000276:immunology*; D008875:Middle Aged
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains