title: Immunogenicity and safety of two schedules of Hepatitis B vaccination during pregnancy.
abstract: OBJECTIVE
  To test the immunogenicity and safety of HepatitisB (HB) vaccination during pregnancy and passive transfer of antibodies to the newborn.
  
  
  METHODS
  Ninety-nine HBsAg-negative pregnant women were divided randomly in two groups; group I was given two, and group II was given three doses of recombinant Hepatitis B vaccine and followed up until 4 months after delivery.
  
  
  RESULTS
  The vaccination was safe. The maternal anti-HB antibody levels at delivery were significantly higher in three dose schedule as compared to two dose schedule. Similarly, the antibody levels in the newborns were higher in the three dose schedule. The maternal antibody levels were higher at 2 and 4 months post-delivery in group II but were observed to be declining in the newborns.
  
  
  CONCLUSIONS
  Hepatitis B vaccination during pregnancy is safe and highly immunogenic, and there is passive transfer of antibodies to the newborns.
authors.affiliation: Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. medinst@pgi.chd.nic.in
authors.forename: Indu
authors.initials: I
authors.lastname: Gupta
authors.forename: Radha K
authors.initials: RK
authors.lastname: Ratho
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007231:Infant, Newborn; D011247:Pregnancy; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines