title: Solcoseryl, a tissue respiration stimulating agent, significantly enhances the effect of capacitively coupled electric field on the promotion of bone formation around dental implants.
abstract: In the present study we examined the combined effect of application of a capacitively coupled electric field (CCEF) and the tissue respiration stimulating agent, Solcoseryl, on the promotion of bone formation around dental implants histologically and mechanically. After a dental implant was inserted into each femur of Japanese white rabbits, Solcoseryl (2 ml/kg) was administered intravenously in the ear vein and a CCEF was applied for 4 h per day for 14 days. The degree of bone formation on microscopic observation, bone contact ratio, bone surface area ratio, and the level of removal torque of the implant in the Solcoseryl- and CCEF-treated group were significantly higher than the respective value in the control group, which had not been treated with Solcoseryl nor CCEF. Thus, the combination of CCEF stimulation and Solcoseryl effectively promoted the formation of new bone. It is suggested that the clinical use of a combination of CCEF stimulation and Solcoseryl for dental implants promotes osseointegration.
authors.affiliation: Department of Fixed Prosthodontics, and Tohru Kaku, Department of Oral Pathology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan. ochident@hoku-iryo-u.ac.jp
authors.forename: Morio
authors.initials: M
authors.lastname: Ochi
authors.forename: Pao-Li
authors.initials: PL
authors.lastname: Wang
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ohura
authors.forename: Shigenori
authors.initials: S
authors.lastname: Takashima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kagami
authors.forename: Yukito
authors.initials: Y
authors.lastname: Hirose
authors.forename: Tohru
authors.initials: T
authors.lastname: Kaku
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Sakaguchi
mesh_terms: D000183:Actihaemyl / Q000627:therapeutic use*; D000704:Analysis of Variance; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D004396:Coloring Agents; D015921:Dental Implants; D025802:Electric Capacitance / Q000627:therapeutic use; D004599:Electric Stimulation Therapy / Q000379:methods; D005269:Femur; D005456:Fluorescent Dyes; D008297:Male; D016348:Osseointegration; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology; D010101:Oxygen Consumption / Q000187:drug effects*; D011817:Rabbits; D013314:Stress, Mechanical; D013499:Surface Properties; D019415:Torque
chemical_list: D004396:Coloring Agents; D015921:Dental Implants; D005456:Fluorescent Dyes; D000183:Actihaemyl