Crystallography of membrane proteins, major targets in drug design.
Protein crystallography has the potential to accelerate drug discovery greatly. High-resolution structures of membrane proteins of pharmaceutical interest open new perspectives in drug design. Recent structural data obtained for cyclooxygenases, monoamine oxidase, squalene cyclase, rhodopsine, porins, aquaporins, and ABC transporters are presented and briefly discussed.
Wouters
J
J
Institut de Recherches Microbiologiques JM Wiame, 1 Av E.Gryson, B-1070 Brussels, Belgium. jwouters@dbm.ulb.ac.be
D018360:Crystallography, X-Ray; D015195:Drug Design; D006801:Humans; D008190:Lyases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D008565:Membrane Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D008995:Monoamine Oxidase / Q000737:chemistry; D011451:Prostaglandin-Endoperoxide Synthases / Q000737:chemistry; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000737:chemistry
D008565:Membrane Proteins; D043562:Receptors, G-Protein-Coupled; D011451:Prostaglandin-Endoperoxide Synthases; D008995:Monoamine Oxidase; D008190:Lyases; C022651:squalene cyclase