title: Characteristics of optic disc changes in Taiwanese patients with primary angle-closure glaucoma.
abstract: OBJECTIVE
  Primary angle-closure glaucoma (PACG) is the predominant form of glaucoma among Asians. Although numerous studies have been done to describe the characteristic optic disc changes in patients with primary open angle glaucoma (POAG) which is the predominant form of glaucoma among Western populations, few studies have evaluated the optic disc changes in patients with PACG. The aim of this study was to elucidate the characteristic intrapapillary and parapapillary disc changes in PACG in a cross-sectional study and to develop a practical approach to the detection of glaucomatous optic disc changes in PACG by ophthalmoscopic examination.
  
  
  METHODS
  A total of 103 eyes in 103 PACG patients were studied. Forty one eyes of 41 age- and sex-matched healthy subjects served as controls. Three glaucoma-trained subspecialists examined stereophotographs of optic discs to evaluate the intrapapillary and parapapillary changes. The differences in PACG and control group eyes were compared.
  
  
  RESULTS
  Concentric steep enlargement of the optic disc was found in 99 PACG eyes (96%). Local notching was noted in only 3 eyes, and vertically oval-shaped cupping of the optic disc in only 1 eye. Disc hemorrhage was not detected in any eye. Parapapillary atrophy of the alpha zone involving both temporal and nasal side of the optic disc and parapapillary atrophy of beta zone were significantly more frequent in the PACG group. The presence of an alpha zone or a beta zone simultaneously involving both the temporal and nasal side of the optic disc was associated with more severe optic nerve head damage.
  
  
  CONCLUSIONS
  The intrapapillary change in the PACG group eyes reflected the development of cupping in PACG patients with small and compact optic discs. The parapapillary atrophy paralleled the intrapapillary optic disc cupping in eyes of the PACG group.
authors.affiliation: Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Chang-Hao
authors.initials: CH
authors.lastname: Yang
authors.forename: Por-Tying
authors.initials: PT
authors.lastname: Hung
authors.forename: Luke L-K
authors.initials: LL
authors.lastname: Lin
authors.forename: Jui-Wen
authors.initials: JW
authors.lastname: Hsieh
authors.forename: Tsing-Hong
authors.initials: TH
authors.lastname: Wang
authors.forename: I Jong
authors.initials: IJ
authors.lastname: Wang
mesh_terms: D016022:Case-Control Studies; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009896:Optic Atrophy / Q000209:etiology / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D013624:Taiwan