title: Laser-induced thermotherapy (LITT) of liver metastases: MR-guided percutaneous insertion of an MRI-compatible irrigated microcatheter system using a closed high-field unit.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of a new MRI-compatible irrigated laser microcatheter system for thermal ablation of liver metastases.
  
  
  METHODS
  The new microcatheter system consists of a titanium needle with a diameter of 1.5 mm and a surrounding Teflon catheter with an outer diameter of 1.8 mm (5.5 F). In vitro laser-induced coagulation of bovine liver tissue was performed to determine the optimal perfusion rate of cooling saline flow, maximum laser energy, and ablation time. Laser-induced thermotherapy using the new microcatheter system, an Nd:YAG laser (Dornier), and a flexible laser light guide (Somatex GmbH, Berlin, Germany) was performed in 28 patients with liver metastases. Percutaneous insertion and positioning of multiple microcatheters in the lesion and monitoring of therapy was performed with a closed high-field MRI scanner using T1-weighted gradient-echo sequences during breath-hold.
  
  
  RESULTS
  A perfusion rate of 0.75 mL/minute, a laser energy of 15 W, and an ablation time of 20 minutes were found suitable to achieve safe and sufficient ablation of metastatic tissue. The mean volume of induced coagulation in vitro was 23.9 mL. Ablation of liver metastases in patients was technically and clinically successful.
  
  
  CONCLUSIONS
  The new microcatheter system allows for both catheter placement and monitoring of therapy using a single imaging modality. This shortens the procedure and enables more precise puncture and therapy of liver metastases. Due to the miniaturized design of the catheter and the real-time monitoring, the procedure is minimally invasive and very well tolerated by patients. This new technique seems to be a safe and feasible alternative in treating liver metastases.
authors.affiliation: Radiology Departments, Charité, Humboldt University of Berlin, Germany. puls@charite.de
authors.forename: Ralf
authors.initials: R
authors.lastname: Puls
authors.forename: Christian
authors.initials: C
authors.lastname: Stroszczynski
authors.forename: Gunnar
authors.initials: G
authors.lastname: Gaffke
authors.forename: Norbert
authors.initials: N
authors.lastname: Hosten
authors.forename: Roland
authors.initials: R
authors.lastname: Felix
authors.forename: Ulrich
authors.initials: U
authors.lastname: Speck
mesh_terms: D000368:Aged; D000818:Animals; D017115:Catheter Ablation / Q000295:instrumentation / Q000379:methods*; D002417:Cattle; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D066298:In Vitro Techniques; D053685:Laser Therapy; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged