[Webbing of the neck and nasal bone--prenatal screening for Down syndrome].
The risk of giving birth to a child with Down syndrome increases with maternal age. If in Denmark the mother is older than 35-years she belongs to a high-risk group and will be offered amniocentesis or chorionic villus sampling. We describe different scenarios of risk calculation for Down syndrome based on combinations of nuchal translucency, nasal bone, and/or integrated hormone test. The combination of nuchal translucency and visualisation of the nasal bone between gestational age 11 weeks and 13 + 6 has turned out to be as good a predictive marker as nuchal translucency and integrated hormone test.
Svennekjaer
Sidsel
S
Ultralydklinikken 4023, JMC, H:S Rigshospitalet, DK-2100 København Ø.
Skibsted
Lillian
L
D000328:Adult; D000649:Amniocentesis; D015415:Biomarkers / Q000097:blood; D015193:Chorionic Villi Sampling; D004314:Down Syndrome / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005865:Gestational Age; D006801:Humans; D008423:Maternal Age; D009295:Nasal Bone / Q000002:abnormalities* / Q000000981:diagnostic imaging; D009333:Neck / Q000002:abnormalities* / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D011296:Prenatal Diagnosis / Q000379:methods; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal
D015415:Biomarkers