Metabolic interactions between restraint stress and L-lysine: the effect on urea cycle components.
We studied the effects of L-lysine on wrap-restraint stress-induced changes in ureagenesis. An exposure to wrap-restraint stress did not affect the plasma concentration of L-lysine, but did decrease plasma urea and arginine. Oral L-lysine (1 g/kg) blocked the effect of stress on ureagenesis, and enhanced the effect of stress on L-arginine. No influence of L-lysine were found in controls. The results imply a stress-specific, ureagenesis-stimulating effect of L-lysine, and suggest an increased requirement for L-arginine during the above conditions.
Smriga
M
M
Ajinomoto Co. Inc., Institute of Life Sciences, Suzuki-cho, Kawasaki, Japan. miroslav_smriga@ajinomoto.com
Torii
K
K
D000818:Animals; D001120:Arginine / Q000097:blood; D043183:Irritable Bowel Syndrome / Q000097:blood; D008239:Lysine / Q000097:blood / Q000378:metabolism*; D008297:Male; D009952:Ornithine / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000097:blood / Q000378:metabolism*; D014508:Urea / Q000097:blood*
D014508:Urea; D001120:Arginine; D009952:Ornithine; D008239:Lysine