Hallmarks of Caenorhabditis elegans N-glycosylation: complexity and controversy.
Caenorhabditis elegans has become one of the most widely used model organisms for a range of molecular cell biological applications and is being increasingly used by glycobiologists. However, a major problem has been the lack of knowledge of the structure of the protein-linked glycans from this organism. In recent years several groups have published structural data, particularly N-glycan structural data. However, some of these data are contradictory. In this review we critically assess all the N-glycan structural data and consider how close we are in our goal of defining the glycome of C. elegans.
Haslam
S M
SM
Department of Biological Sciences, Imperial College London, London SW7 2AZ, UK.
Dell
A
A
D000818:Animals; D017173:Caenorhabditis elegans / Q000737:chemistry / Q000378:metabolism*; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D011134:Polysaccharides / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification*
D011134:Polysaccharides