The effect of metformin treatment to ovarian response in cases with PCOS.
OBJECTIVE
To examine the effect of metformin therapy on ovarian response in clomiphene-resistant PCOS patients.


METHODS
Randomized prospective study.


METHODS
Zeynep Kamil Hospital IVF Center.


METHODS
Thirty-two female PCOS patients with clomiphene citrate resistance.


METHODS
Test group A received 2x850 mg/day metformin therapy for 8 weeks, followed by gonadotropin induction. Only gonadotropin induction was applied to Control group B.


METHODS
Total gonadotropin dosage, duration of gonadotropin therapy, estradiol level on HCG-day, number of follicles with >or=16 mm diameter, number of cases with hyperstimulation development, number of cancelled cycles, endometrial thickness on HCG-day, pregnancy outcome, multiple pregnancy rate.


RESULTS
The total gonadotropin doses given to metformin-study group was significantly lower than the control group. In addition, duration of therapy, HCG level, plasma estradiol level on HCG-day in the study group was significantly lower than in the control group.


CONCLUSIONS
Metformin therapy has led to a higher pregnancy outcome, as well as to a decrease in hyperstimulation risk, cycle cancellations, and multiple pregnancy rates with a lower gonadotropin dosage.
Tasdemir
Seval
S
Zeynep Kamil Women and Children's Hospital, IVF-Centre, Istanbul, Turkey.
Ficicioglu
Cem
C
Yalti
Serap
S
Gurbuz
Birgül
B
Basaran
Toygun
T
Yildirim
Gazi
G
D000328:Adult; D005260:Female; D005299:Fertility Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006062:Gonadotropins / Q000008:administration & dosage; D006801:Humans; D008687:Metformin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010060:Ovulation / Q000187:drug effects*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D016896:Treatment Outcome
D005299:Fertility Agents; D006062:Gonadotropins; D008687:Metformin