Synthesis, characterization and mutagenicity of new cis-[Pt(2-substituted-benzimidazole)2Cl2] complexes.
In this study, four new platinum(II) complexes with the structures cis-[Pt(Ligand)2Cl2] (ligand = 2-(p-methoxy-/or-p-chlorobenzyl or p-methoxyphenyl)benzimidazol (1, 2, 4 respectively) and 5(6)-methyl-2-phenoxymethylbenzimidazole (3) were synthesized and characterized by their elemental analysis, and IR and 1H NMR spectra. The potentials of the Pt(II) complexes for short-term bacterial mutagenicity were tested in reverse-mutation assays using Salmonella typhimurium frame-shift strain T 98 and S. typhimurium TA 100 and TA 102 strains, which carry mutations particularly sensitive to reversion by DNA base-pair substitution. The tests were performed in the absence of S9 rat liver fraction. Among the complexes tested 1 had no mutagenic activity. Complex 4 was found to be weakly mutagenic in TA 98 only. The Pt(II) complexes 2 and 3 were found to be mutagenic in TA 98, TA 100 and TA 102.
Gümüş
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Etiler, Ankara, Turkey. gumusf@pharmacy.gazi.edu.tr
Demirci
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Ozden
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Eroğlu
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Diril
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D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004354:Drug Screening Assays, Antitumor; D066298:In Vitro Techniques; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D009152:Mutagenicity Tests; D009153:Mutagens / Q000138:chemical synthesis* / Q000494:pharmacology*; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics; D013055:Spectrophotometry, Infrared
D000970:Antineoplastic Agents; D001562:Benzimidazoles; D008024:Ligands; D009153:Mutagens; D009944:Organoplatinum Compounds