title: [Association between glutathione S-transferase M1 gene deletion and genetic susceptibility to endometriosis].
abstract: OBJECTIVE
  To evaluate the possible association of the glutathione S-transferase M1 (GSTM1) gene polymorphism with the susceptibility to endometriosis in women of Han nationality in Guangdong Province.
  
  
  METHODS
  Polymerase chain reaction was used to identify the GSTM1 genotypes in 76 patients with endometriosis and 80 controls (surgical patients for gynecological problems other than endometriosis).
  
  
  RESULTS
  The frequencies of the GSTM1 null genotypes in patients with endometriosis and controls were 65.8% and 46.3%, respectively, showing a significant difference between the endometriotic cohort and the control group (X(2)=6.03, P < 0.05). Individuals with GSTM1 null genotype were exposed to risks for endometriosis 2.24 times that of subjects without these genotypes OR=2.24, 95% CI=1.17-4.27 .
  
  
  CONCLUSIONS
  GSTM1 gene deletion might bea risk factor for endometriosis in women of Han nationality who are native residents in Guangdong Province.
authors.affiliation: Department of Obstetrics and Gynecology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. pdx@fimmu.com
authors.forename: Dong-xian
authors.initials: DX
authors.lastname: Peng
authors.forename: Yuan-li
authors.initials: YL
authors.lastname: He
authors.forename: Li-wen
authors.initials: LW
authors.lastname: Qiu
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.forename: Jing-ming
authors.initials: JM
authors.lastname: Lin
mesh_terms: D000328:Adult; D004715:Endometriosis / Q000201:enzymology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008875:Middle Aged
chemical_list: D005982:Glutathione Transferase