First total synthesis of the neuronal cell protecting carbazole alkaloid carbazomadurin A by sequential transition metal-catalyzed reactions.
The highly oxygenated neuronal cell protecting carbazole alkaloid carbazomadurin A was synthesized in nine steps and 11% overall yield from isovanillic acid.
Knölker
Hans-Joachim
HJ
Institut für Organische Chemie, Technische Universität Dresden, Bergstrasse 66, 01069 Dresden, Germany. hans-joachim.knoelker@chemie.tu-dresden.de
Knöll
Jan
J
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D019610:Cytoprotection; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D009474:Neurons / Q000166:cytology*
D000470:Alkaloids; D002227:Carbazoles; D008670:Metals; C109013:carbazomadurin A