title: Cytotoxic pentacyclic triterpenes from Combretum nigricans.
abstract: A new pentacyclic triterpene, 11alpha-acetoxy-20,24-epoxy-25-hydroxy-dammar-3-one (1), has been isolated from the African tree Combretum nigricans, together with the known corresponding diol, 20,24-epoxy-11alpha, 25-dihydroxy-dammar-3-one (2). They are responsible, at least in part, for the cytotoxic activity of the methanolic extract of the plant.
authors.affiliation: Unibioscreen SA, EEBIC, 40 Av. J. Wybran, Brussels 1070, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Simon
authors.forename: J
authors.initials: J
authors.lastname: Dewelle
authors.forename: O
authors.initials: O
authors.lastname: Nacoulma
authors.forename: P
authors.initials: P
authors.lastname: Guissou
authors.forename: R
authors.initials: R
authors.lastname: Kiss
authors.forename: D
authors.initials: D
authors.lastname: Daloze
authors.forename: J C
authors.initials: JC
authors.lastname: Braekman
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D029765:Combretum; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D014315:Triterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects; D000097669:Dammaranes
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D014315:Triterpenes; D000097669:Dammaranes