[The expression and significance of structural proteins, VEGF and Ang-1 in cavernous venous malformations of the body surface].
OBJECTIVE
To study the expression and significance of structural proteins, VEGF and Ang-1 in cavernous venous malformations of the body surface.


METHODS
Tissue samples came from 25 cases of cavernous venous malformations, 12 cases of normal moderate veins and 12 cases of normal small veins. Envision immunohistochemical stain was used to investigate the expression of IV collagen, fibronectin, laminin, VEGF and Ang-1. The results were analyzed semi-quantitatively.


RESULTS
The distribution of structural proteins in cavernous venous malformations is similar to moderate and small veins, but the expression in venous malformations is less obviously. VEGF expression in cavernous venous malformations and small veins is stronger obviously than moderate veins. Ang-1 expression in small veins is stronger remarkably than cavernous venous malformations and moderate veins.


CONCLUSIONS
The abnormal expression of structural proteins may be an important factor in etiopathology and progress of cavernous venous malformations. There is disturbance of blood vessel remodelling in the sinusoid of cavernous venous malformations, with which the less expression of Ang-1 may be related.
Ouyang
Tian-xiang
TX
Department of Plastic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Yuan
Si-ming
SM
Xing
Xin
X
Ni
Can-rong
CR
Zheng
Wei-qiang
WQ
Wen
Ping
P
D042683:Angiopoietin-1 / Q000378:metabolism*; D024141:Collagen Type IV / Q000378:metabolism; D005353:Fibronectins / Q000032:analysis; D006392:Hemangioma, Cavernous / Q000378:metabolism*; D006801:Humans; D007797:Laminin / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D014680:Veins / Q000002:abnormalities* / Q000378:metabolism
C467630:ANGPT1 protein, human; D042683:Angiopoietin-1; D024141:Collagen Type IV; D005353:Fibronectins; D007797:Laminin; D042461:Vascular Endothelial Growth Factor A