title: Lupus-erythematosus-like eruption induced by Trichophyton mentagrophytes infection.
abstract: BACKGROUND
  Several factors are known to trigger acute manifestations of lupus erythematosus (drugs, ultraviolet radiation, bacterial or viral infections, pregnancy), but fungal infections have never been reported to induce lupus-like lesions. We describe 2 children with tinea capitis caused by Trichophyton mentagrophytes(TM), who developed transient skin and serological manifestations of systemic lupus erythematosus.
  
  
  METHODS
  Case 1, a 3-year-old girl, had a kerion due to TM transmitted by an octodon, and a facial skin eruption suggestive of systemic lupus erythematosus. Antinuclear antibodies (ANA) were positive at 1:250. After griseofulvin treatment, the lupus-like rash completely regressed, and the ANA titre decreased. Case 2, a 4-year-old girl, had occipital kerion and an annular scaly erythema on the shoulder caused by TM. She also had a non-scaly rash on the face and a recent history of photosensitivity. The ANA titre was positive at 1:8,000. Cutaneous lesions disappeared after an 8-week griseofulvin therapy, and ANA titres decreased progressively.
  
  
  CONCLUSIONS
  'New pets' are usually the vectors of TM, especially familiar rodents like the degu of Chile (also named octodon). In our 2 cases, lupus-like rashes began before the onset of griseofulvin treatment, suggesting a pathogenic role of the dermatophyte. A wide variety of lesions named 'mycides' was described several decades ago associated with TM infections. We hypothesize that these mycides and the TM-induced lupus-like lesions reported in our 2 cases could represent the same entity.
authors.affiliation: Unité de dermatologie pédiatrique, Hôpital Pellegrin-Enfants, Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Boralevi
authors.forename: C
authors.initials: C
authors.lastname: Léauté-Labrèze
authors.forename: S
authors.initials: S
authors.lastname: Roul
authors.forename: B
authors.initials: B
authors.lastname: Couprie
authors.forename: A
authors.initials: A
authors.lastname: Taïeb
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000382:microbiology; D000935:Antifungal Agents / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006118:Griseofulvin / Q000627:therapeutic use; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000382:microbiology*; D012377:Rodentia / Q000382:microbiology*; D014006:Tinea Capitis / Q000150:complications* / Q000188:drug therapy; D016896:Treatment Outcome; D014249:Trichophyton / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D006118:Griseofulvin