title: Association between CYP2E1 polymorphisms and susceptibility to prostate cancer.
abstract: Several genetic alterations have been associated with sporadic prostate cancer (PCa). In this study, the association between RsaI and DraI polymorphisms of CYP2E1 and PCa risk was analysed in a case-control study of 227 individuals using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Regarding DraI polymorphisms, the DD genotype is over-represented in PCa cases when compared with the control group (odds ratio (OR) 2.12; 95% confidence interval (CI) 1.11-4.05; P=0.022). Regarding the RsaI polymorphism, no significant differences were found. The results of this study indicate that DraI polymorphisms of the CYP2E1 gene may be associated with a twofold increased risk for the development of PCa.
authors.affiliation: Molecular Oncology Unit, Instituto Português de Oncologia do Porto, Portugal. paulamsferreira@mail.com
authors.forename: P M
authors.initials: PM
authors.lastname: Ferreira
authors.forename: R
authors.initials: R
authors.lastname: Medeiros
authors.forename: A
authors.initials: A
authors.lastname: Vasconcelos
authors.forename: S
authors.initials: S
authors.lastname: Costa
authors.forename: D
authors.initials: D
authors.lastname: Pinto
authors.forename: A
authors.initials: A
authors.lastname: Morais
authors.forename: J
authors.initials: J
authors.lastname: Oliveira
authors.forename: C
authors.initials: C
authors.lastname: Lopes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D014408:Biomarkers, Tumor / Q000097:blood; D016022:Case-Control Studies; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011174:Portugal / Q000453:epidemiology; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D044469:Racial Groups / Q000235:genetics; D012307:Risk Factors; D013223:Statistics as Topic
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers; D019392:Cytochrome P-450 CYP2E1; D017430:Prostate-Specific Antigen