[Effect of satragaloside IV on the increase of microvascular permeability induced by histamine in pial microvessels of rat].
OBJECTIVE
To study the effect of satragaloside IV on the microvascular permeability induced by histamine in pial microvessels.


METHODS
The microvascular permeability was expressed by changes in the transendothelial electrical resistance which was measured with technique using microelectrode impaled into the vascular lumen and based on cable analysis of vessels in rat.


RESULTS
The transendothelial electrical resistance of microvessels superfused with artificial cerebrospinal fluid was about 2500 omega.cm2, indicating a tight barrier with extremely low ion permeability, and application of 10(-4) mol.L-1 histamine in superfusate caused a rapid and reversible decrease in transendothelial electrical resistance. In paired experiment, the decrease of transendothelial electrical resistance induced by 10(-4) mol.L-1 histamine was inhibited by adding 0.8 x 10(-4) mol.L-1 satragaloside IV in superfusate.


CONCLUSIONS
The results indicated that increases in the microvascular permeability induced by histamine, and satragaloside IV can inhibit the increases in the microvascular permeability induced by histamine. It is necessary that the cellular mechanism of permeability response induced by satragaloside IV be further elucidated.
Wu
D Z
DZ
Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Hu
Z B
ZB
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D027885:Astragalus propinquus / Q000737:chemistry; D001921:Brain / Q000098:blood supply*; D002199:Capillary Permeability / Q000187:drug effects*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006633:Histamine Antagonists / Q000494:pharmacology; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006027:Glycosides; D006633:Histamine Antagonists; C477970:satragaloside IV