title: [Studies on the chemical constituents from marine brown alga Ishige okamurai (3)].
abstract: OBJECTIVE
  To study the chemical constituents of Ishige okamurai.
  
  
  METHODS
  Compounds were isolated by Pyricularia oryzae bioassay-guided fractionation method in combination with extraction and partitionation as well as multi-chromatography. Their structures were determined by spectral analysis and chemical evidence.
  
  
  RESULTS
  Seven compounds were obtained and identified as (2S)-1-O-palmitoyl-2-O-(11Z-octadecenoyl)-3-O-beta-D-galacto-pyranosyl glycerol (I), (2S)-1-O-palmitoyl-2-O-myristoyl-3-O-(6-sulfo-alpha-D- quinovopyranosyl) glycerol (II), (2S)-1-O-palmitoyl-2-O-palmitoyl-3-O-(6'-sulfo-alpha-D- quinovopyranosyl) glycerol (III) and (2S)-1-O-palmitoyl-2-O-(11Z-octadecenoyl)-3-O-(6'-sulfo-alpha-D- quinovopyranosyl) glycerol (IV), stearic acid (V), methyl myristate(VI) and palmitic acid (VII).
  
  
  CONCLUSIONS
  Compounds I-VI were isolated from the alga for the first time while I, II and IV are new natural products. I-IV showed activity causing morphological abnormality of P. oryzae mycelia.
authors.affiliation: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. haifengtang@hotmail.com
authors.forename: Hai-feng
authors.initials: HF
authors.lastname: Tang
authors.forename: Yang-hua
authors.initials: YH
authors.lastname: Yi
authors.forename: Xin-sheng
authors.initials: XS
authors.lastname: Yao
authors.forename: Jiu-hong
authors.initials: JH
authors.lastname: Wu
authors.forename: Shu-yu
authors.initials: SY
authors.lastname: Zhang
authors.forename: Qiang-zhi
authors.initials: QZ
authors.lastname: Xu
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D006017:Glycolipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D003904:Mitosporic Fungi / Q000187:drug effects; D015394:Molecular Structure; D000459:Phaeophyceae / Q000737:chemistry*; D013229:Stearic Acids / Q000737:chemistry / Q000302:isolation & purification; D014407:Tumor Cells, Cultured
chemical_list: C477175:1-O-palmitoyl-2-O-(11-octadecenoyl)-3-O-galactopyranosylglycerol; C477176:1-O-palmitoyl-2-O-myristoyl-3-O-(6-sulfoquinovopyranosyl)glycerol; D000970:Antineoplastic Agents; D006017:Glycolipids; D013229:Stearic Acids; C031183:stearic acid