Immunologic factors in transplant arteriopathy: insight from animal models.
Transplant arteriopathy is the leading cause of long-term morbidity and mortality following heart transplantation. The pathologic hallmark of this disease is intimal proliferation. Animal models have demonstrated that immunologic factors, including cytokines, cellular adhesion molecules and inflammatory cells, play a significant role in the development of this arteriopathy. One goal of future studies will be to translate findings in animal models into effective treatments in humans.
Alexis
Jeffrey D
JD
Department of Medicine, Box 1030, Mount Sinai School of Medicine, New York, NY 10029, USA. jeffrey.alexis@mssm.edu
Pyo
Robert T
RT
Chereshnev
Igor
I
D000818:Animals; D015815:Cell Adhesion Molecules / Q000276:immunology; D003331:Coronary Vessels / Q000276:immunology / Q000473:pathology*; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D016027:Heart Transplantation / Q000276:immunology*; D007249:Inflammation; D014181:Transplantation Immunology
D015815:Cell Adhesion Molecules; D016207:Cytokines