title: Growth impairment in the very preterm and cognitive and motor performance at 7 years.
abstract: BACKGROUND
  Infants born of low birth weight often have poor subsequent growth (especially if they were born very preterm), which has been shown to relate to later motor and cognitive development.
  
  
  OBJECTIVE
  To assess a cohort of preterm infants at the age of 7 years for growth, motor, and cognitive measures, and investigate the effects of growth impairment on school performance.
  
  
  METHODS
  A cohort of 280 children born before 32 completed weeks of gestation were tested, together with 210 term controls.
  
  
  RESULTS
  Preterm children were significantly lighter and shorter than term controls and had smaller heads and lower body mass index (BMI). Median centiles for weight, height, head circumference, and BMI were 25, 25, 9, and 50 for boys and 50, 25, 9, and 50 for girls compared with 50, 50, 50, and 75 for controls. They performed significantly less well on all tests with a mean score of 91 (9.2) on the Developmental Test of Visual-Motor Integration, 89 (14.5) on the Wechsler-III IQ test, and 30.7% scoring at or below the 5th centile on the Movement Assessment Battery for Children. In boys, short stature and small heads were the best predictors of poor performance; in girls, a small head alone was a predictor for poor motor and cognitive performance.
  
  
  CONCLUSIONS
  Poor postnatal growth in preterm infants, especially of the head, is associated with increased levels of motor and cognitive impairment at 7 years of age. This growth restriction appears to occur largely in the postnatal rather than antenatal period and may be amenable to intervention and subsequent improvement in outcome.
authors.affiliation: Department of Child Health, Institute of Child Health, Royal Liverpool Children's Hospital, Liverpool L12 2AP, UK. mc19@liv.ac.uk
authors.forename: R W I
authors.initials: RW
authors.lastname: Cooke
authors.forename: L
authors.initials: L
authors.lastname: Foulder-Hughes
mesh_terms: D000124:Achievement; D000886:Anthropometry; D015992:Body Mass Index; D002508:Cephalometry; D002648:Child; D003071:Cognition; D002658:Developmental Disabilities / Q000209:etiology*; D005260:Female; D006130:Growth Disorders / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000523:psychology*; D019102:Infant, Very Low Birth Weight / Q000523:psychology*; D007360:Intelligence; D008297:Male; D011379:Prognosis; D011597:Psychomotor Performance; D012044:Regression Analysis; D012307:Risk Factors