Genetic characterization of the unique short segment of phocid herpesvirus type 1 reveals close relationships among alphaherpesviruses of hosts of the order Carnivora.
To further characterize phocid herpesvirus type 1 (PhHV-1) at the molecular level, a cluster of genes comprising the complete unique short (Us) region of PhHV-1 has been cloned and sequenced. Within this region, ORFs were detected that code for the equivalent of the Us 2- protein of herpes simplex virus (HSV), a putative protein kinase, and for the glycoprotein equivalents gG, gD, gI and gE. In addition, two small ORFs downstream of gE, homologous to the Us 8.5 and Us 9 proteins of HSV were identified. Comparative analysis of the ORF encoding the gD equivalent of PhHV-1 identified the corresponding proteins of the alphaherpesviruses canine herpesvirus and, to lesser degree, feline herpesvirus as the closest relatives.
Martina
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BEE
Seal Rehabilitation and Research Centre, Hoofdstraat 94a, 9968 AG Pieterburen, The Netherlands.
Harder
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TC
Central Laboratory, Federal State of Schleswig-Holstein, Max-Eyth-Str. 5, D-24537 Neumuenster, Germany.
Osterhaus
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ADME
Erasmus MC, Institute of Virology, PO Box 1738, 3000 DR Rotterdam, The Netherlands.|Seal Rehabilitation and Research Centre, Hoofdstraat 94a, 9968 AG Pieterburen, The Netherlands.
D018138:Alphaherpesvirinae / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D000818:Animals; D002335:Carnivora / Q000821:virology; D003001:Cloning, Molecular; D005814:Genes, Viral; D005810:Multigene Family; D016366:Open Reading Frames; D010802:Phylogeny; D046048:Seals, Earless / Q000821:virology*; D013045:Species Specificity; D014764:Viral Proteins / Q000235:genetics
D014764:Viral Proteins