Immunological and endocrinological studies on lymphocyte subpopulation and medical treatment for infertility in patients with endometriosis.
We investigated the relationship between interleukin-6 (IL-6) levels and subset profiles of T lymphocyte (T-cell) and macrophage in peritoneal fluid (PF) with or without endometriosis (EM). IL-6 levels in PF with EM were significantly higher than those without EM. IL-6 producing cells with EM were analyzed in each activated mature T-cell (CD3+CD69+) and macrophage (CD14+) were 0.5 and 3.5%, respectively, whereas it was mostly negative in those without EM. Cytotoxic T-cell (CD8+CD11b-) profiles in PF with EM were also quiet different from those without EM. Cellular immunity in the peripheral blood did not change during the course of IVF-ET cycles, although plasma levels of ovarian steroid hormones significantly increased comparing with that in normal ovarian cycles. Cytotoxic T-cell type 1 (Tc1) profiles might be useful predictive values in the pregnancy outcome for infertile patients with EM.
Furuya
Kenichi
K
Department of Obstetrics and Gynecology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.
Murakami
Mitsutaka
M
Makimura
Noriko
N
Matsuda
Hideo
H
Ikou
Kanoko
K
Saito
Keiko
K
Kawakami
Yuichi
Y
Shibazaki
Tomoko
T
Fukui
Utako
U
Mizumoto
Yoshifumi
Y
Tokuoka
Susumu
S
Nagata
Ichiro
I
Kikuchi
Yoshihiro
Y
D001202:Ascitic Fluid / Q000166:cytology / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D004715:Endometriosis / Q000150:complications / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D015850:Interleukin-6 / Q000378:metabolism; D008264:Macrophages / Q000276:immunology; D011247:Pregnancy; D011256:Pregnancy Outcome; D027724:Reproductive Techniques, Assisted; D013256:Steroids / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016207:Cytokines; D015850:Interleukin-6; D013256:Steroids