[Triterpenoid saponins from bark Mitragyna inermis].
OBJECTIVE
To study the constituents of Mitragyna inermis that have an anti-tumor activity on Bel-7402 of hepatic carcinoma.


METHODS
The compounds were isolated by column chromatography on silica gel, ODS, Sephadex LH-20 separately and their structures were elucidated by chemical and spectral technology.


RESULTS
Three quinovic acid glycosides, quinovic acid 3 beta-beta-D-glucopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-28-O-beta- D-glucopyranoside(I), quinovic acid 3 beta-O-beta-D-quinovopyranoside(II), quinovic acid 3 beta-O-beta-D-glucopyranoside(III), were obtained.


CONCLUSIONS
I, II were isolated from Mitragyna for the first time.
Cheng
Zhi-hong
ZH
National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China.
Yu
Bo-yang
BY
Yang
Xiu-wei
XW
Zhang
Jian
J
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology; D032065:Mitragyna / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; C477178:quinovic acid 3-O-quinovopyranoside; C477177:quinovic acid 3-glucopyranosyl-1-4-rhamnopyranosyl-28-O-glucopyranoside