[The protective effects of tea catechins on the injury of cerebral ischemia and reperfusion in rats].
OBJECTIVE
The protective effects of tea catechins on the injury of cerebral ischemia and reperfusion in rats were observed with rat cerebral ischemia and reperfusion model produced by bilaterally clamping the common carotid arteries and vagus nerves for 60 min and then removing the occlusion for 30 min.


METHODS
Wistar rats were divided into normal control group, model group and catechin group (30 mg.kg-1 and 50 mg.kg-1 i.p., qd x 7 d). The changes of biochemical indications and pathology were observed.


RESULTS
The results presented that the concentration of MDA in brain tissue and serum of model rats were higher than that of control rats(P < 0.01). Compared with model group, tea catechin groups could decrease the concentration of MDA in brain tissue and serum, and tea catechin group (50 mg.kg-1 i.p., qd x 7 d) could improve the injury of blood brain barrier.


CONCLUSIONS
Tea catechins have protective effects on the injury of cerebral ischemia and reperfusion in rats.
Fang
F
F
School of Chemical Engineering Tianjin University, Tianjin 300072, China.
Han
Y J
YJ
Cui
Z Q
ZQ
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology; D002392:Catechin / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism* / Q000473:pathology; D013662:Tea / Q000737:chemistry*
D018696:Neuroprotective Agents; D013662:Tea; D008315:Malondialdehyde; D002392:Catechin