title: PDGF and TGF-beta partially prevent 2-deoxy-D-ribose-induced apoptosis in the fat body cell line IPLB-LdFB from the insect Lymantria dispar.
abstract: The IPLB-LdFB cell line from the fat body of the insect Lymantria dispar shows the presence of immunoreactive, platelet-derived growth factor (PDGF)-AB and transforming growth factor (TGF)-beta1 molecules, as well as the corresponding plasma membrane-like receptors, i.e. PDGFR-alpha, PDGFR-beta and TGFR-beta type II. Cytofluorimetric and morphological studies reveal that the reducing sugar 2-deoxy-D-ribose (dRib), an apoptotic agent for human cells, induces apoptosis in a concentration- and time-dependent manner even in IPLB-LdFB cells. PDGF-AB and TGF-beta1 partially counteract the effect of dRib, indicating a survival role of these factors in this apoptotic model of insect cells.
authors.affiliation: Department of Animal Biology, University of Modena and Reggio Emilia, Via Berengario 14, 41100, Modena, Italy
authors.forename: E
authors.initials: E
authors.lastname: Ottaviani
authors.forename: D
authors.initials: D
authors.lastname: Barbieri
authors.forename: A
authors.initials: A
authors.lastname: Franchini
authors.forename: D
authors.initials: D
authors.lastname: Kletsas