HEPN: a common domain in bacterial drug resistance and human neurodegenerative proteins.
A novel domain - HEPN (higher eukarytoes and prokaryotes nucleotide-binding domain) - found in several bacterial species is also present in the human protein, sacsin, a chaperonin implicated in an early-onset neurodegenerative disease. The distant structural similarity suggests that this domain might be involved in nucleotide binding.
Grynberg
Marcin
M
Program in Bioinformatics and Systems Biology, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Erlandsen
Heidi
H
Godzik
Adam
A
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D024881:Drug Resistance, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*
D001426:Bacterial Proteins; D011506:Proteins