Generation of CD8+ cytotoxic T lymphocytes against breast cancer cells by stimulation with mammaglobin-A-pulsed dendritic cells.
Mammaglobin-A is exclusively expressed by breast cancer cells. Thus, mammaglobin-A-specific T cell immune responses may be useful for the design of new breast cancer-specific immunotherapies. We show herein that CD8+ T cells generated against recombinant mammaglobin-A-pulsed dendritic cells display a marked cytotoxic activity against mammaglobin-A-positive breast cancer cell lines. This study indicates the immunotherapeutic potential of this novel antigen for the treatment of breast cancer.
Manna
Partha P
PP
Department of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Jaramillo
Andrés
A
Majumder
Kanchana
K
Campbell
Lacey G
LG
Fleming
Timothy P
TP
Dietz
Jill R
JR
Dipersio
John F
JF
Mohanakumar
T
T
D000918:Antibody Specificity; D001943:Breast Neoplasms / Q000276:immunology* / Q000628:therapy; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002461:Cell Line, Transformed; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D016219:Immunotherapy, Adoptive; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D060785:Mammaglobin A; D009363:Neoplasm Proteins / Q000276:immunology*; D014407:Tumor Cells, Cultured; D014598:Uteroglobin / Q000276:immunology*
D060785:Mammaglobin A; D009363:Neoplasm Proteins; C556448:SCGB2A2 protein, human; D014598:Uteroglobin