title: WHO Expert Committee on Drug Dependence.
abstract: This report presents the recommendations of a WHO Expert Committee responsible for reviewing information on dependence-producing drugs to assess the need for their international control. The first part of the report contains a description of the procedure for the review of dependence-producing substances. This is followed by a critical review of five psychoactive substances (amfepramone, amineptine, buprenorphine, delta-9-tetrahydrocannabinol and tramadol). The report also discusses the substances that were pre-reviewed by the Committee, four of which (ketamine, zopiclone, butorphanol and khat) were recommended for critical review at a future meeting. The final section discusses the problems of the terminology used in reporting abuse-related adverse drug reactions and describes how confusion affects the reporting of adverse effects using the example of the selective serotonin reuptake inhibitors.
mesh_terms: D026683:Advisory Committees; D004341:Drug Evaluation; D004335:Drug and Narcotic Control; D006801:Humans; D017410:Practice Guidelines as Topic; D011358:Product Surveillance, Postmarketing; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use*; D019966:Substance-Related Disorders / Q000517:prevention & control*; D014944:World Health Organization
chemical_list: D011619:Psychotropic Drugs