title: [Studies on the anti-inflammation effect of the TCM prescription of a combination of monkshood root with peony root].
abstract: OBJECTIVE
  To make a comparison between the single and combined use of Monkshood Root and Peony Root to observe the anti-inflammation effect in the experimental animals.
  
  
  METHODS
  The experimental inflammatory models were adopted, i.e. adjuvant-induced polyarthritis carrageenan-induced or formaldehyde-induced rat paw edema, and cotton pellet-induced granuloma formation in rats xylene-induced mouse ear edema, exudation of abdominal blood capillaries of mice, etc.
  
  
  RESULTS
  The anti-inflammafion effect of Monkshood Root was weaker than that of Peony Root or Peony Root combined with Monkshood Root. It was found that anti-inflammation effect with the drug-cooperation was enhanced more significantly in the formaldehyde-induced or adjuvant-induceed arthritis models than in the carrageenan-induced rat paw edema and other inflammatory models either in the large dosage of 1:1 proportion or in the small dosage of 1:2 proportion.
  
  
  CONCLUSIONS
  The drug-cooperation has a good selective and synergic effect on anti-inflammation.
authors.affiliation: Shandong University of TCM, Jinan 250014, Shandong, China.
authors.forename: Hui-yun
authors.initials: HY
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Qin
authors.forename: Ling
authors.initials: L
authors.lastname: Xue
authors.forename: Shao-hua
authors.initials: SH
authors.lastname: Zhang
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy*; D005260:Female; D015745:Granuloma, Foreign-Body / Q000188:drug therapy; D008297:Male; D051379:Mice; D029596:Paeonia / Q000737:chemistry*; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal