Overeating, alcohol and sucrose consumption decrease in CB1 receptor deleted mice.
Administration of the cannabinoid CB1 receptor antagonist SR141716 (3-10 mg/kg i.p.) abolished neuropeptide Y-induced overeating and significantly reduced ethanol and sucrose intake in CB1 wild-type (+/+) mice. In CB1 receptor knockout (-/-) mice, neuropeptide Y totally lost its capacity to increase food consumption. Similarly, sucrose and ethanol intakes were significantly lower in CB1-/- vs. CB1+/+ mice. In CB1 deficient mice, SR141716 had no effect in these models.
Poncelet
Martine
M
Central Nervous System Department, Sanofi-Synthélabo Recherche, 371 rue du Professeur Joseph Blayac, 34184 Montpellier Cedex 04, France. martine.poncelet@sanofi-synthelabo.com
Maruani
Jeanne
J
Calassi
Roselyne
R
Soubrié
Philippe
P
D000428:Alcohol Drinking / Q000235:genetics*; D000818:Animals; D004435:Eating / Q000235:genetics*; D005518:Food Preferences / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009478:Neuropeptide Y / Q000037:antagonists & inhibitors; D010880:Piperidines / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000037:antagonists & inhibitors / Q000235:genetics*; D000077285:Rimonabant; D013395:Sucrose
D009478:Neuropeptide Y; D010880:Piperidines; D011720:Pyrazoles; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D013395:Sucrose; D000077285:Rimonabant