[Effect of protein and anthraquinone glucosides from cassia seed on serum lipid of hyperlipidemia rats].
OBJECTIVE
To study the effect of protein and anthraquinone glucosides from cassia seed on serum lipid of hyperlipidemia rats.


METHODS
The rat hyperlipidemia model was set up by ig lipid emulsion. The effects of the protein 0.25 and 1 mg.kg-1. d-1, the anthraquinone glucosides 5 and 20 mg.kg-1.d-1, and the protein 0.25 mg.kg-1.d-1 plus the anthracene glucosides 5 mg.kg-1.d-1 on total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) in serum of the rats were determined.


RESULTS
The protein 1 mg.kg-1.d-1, the anthraquinone glucosides 20 mg.kg-1.d-1 reduced the raised TC, TG, LDL-C of hyperlipidemia rats (P < 0.05). The above indexes could also be reduced by the protein 0.25 mg.kg-1.d-1 plus the anthraquinone glucosides 5 mg.kg-1.d-1(P < 0.05, P < 0.01).


CONCLUSIONS
Protein and anthraquinone glucosides from cassia seed can lower TC, TG, LDL-C of hyperlipidemia rats.
Li
Xu-e
XE
Institute of Biological Technology, South China Normal University, Guangzhou 510631, Guangdong, China. lixue@scnu.edu.cn
Guo
Bao-jiang
BJ
D000818:Animals; D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology*; D002366:Cassia / Q000737:chemistry*; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006943:Hyperglycemia / Q000097:blood*; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D010940:Plant Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D012639:Seeds / Q000737:chemistry; D014280:Triglycerides / Q000097:blood*
D000880:Anthraquinones; D008078:Cholesterol, LDL; D007004:Hypoglycemic Agents; D010940:Plant Proteins; D014280:Triglycerides; D002784:Cholesterol