Herpes simplex virus latency-associated transcript gene function.
A major area of interest in the study of herpes simplex virus type 1 (HSV-1) involves the persistence of the virus within a latent state in neuronal cells of infected humans. The latency-associated transcripts (LATs) are believed to play a key role during HSV-1 latency. This review will discuss the most recent findings on the involvement of the LAT region with apoptotic pathways and how this relates to other potential functions of the LATs.
Kent
Jennifer R
JR
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076, USA.
Kang
Wen
W
Miller
Cathie G
CG
Fraser
Nigel W
NW
D000818:Animals; D017209:Apoptosis; D015967:Gene Expression Regulation, Viral; D005807:Genes, Overlapping; D005814:Genes, Viral; D018259:Herpesvirus 1, Human / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics; D051379:Mice; D009474:Neurons / Q000473:pathology / Q000821:virology; D012367:RNA, Viral / Q000235:genetics*; D011817:Rabbits; D014158:Transcription, Genetic; D017735:Virus Latency / Q000235:genetics*
D012367:RNA, Viral