Cellular physiology of the neonatal rat cerebral cortex.
The early development of the cerebral cortex is characterized by neurogenesis, neuronal migration, cellular differentiation and programmed cell death. Cajal-Retzius cells, developing cortical plate neurons and subplate cells form a transient synaptic circuit which may serve as a template for the formation of cortical layers and columns. These three neuronal cell types show distinct electrophysiological properties and synaptic inputs. Endogenous or exogenous harmful disturbances during this developmental period may lead to the preservation of early cortical circuits, which may act as trigger zones for the initiation of pathophysiological activity.
Luhmann
Heiko J
HJ
Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, D-55128, Mainz, Germany. luhmann@uni-mainz.de
Hanganu
Ileana
I
Kilb
Werner
W
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000033:anatomy & histology* / Q000502:physiology*; D002468:Cell Physiological Phenomena / Q000187:drug effects; D002540:Cerebral Cortex / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D051381:Rats