title: Design and synthesis of phosphotyrosine mimetics.
abstract: Selective inhibitors of protein tyrosine phosphatases (PTPases) are of great interest as therapeutic agents and research tools. Several phenylalanine derivatives (1, 2) designed as phosphotyrosine mimetics or irreversible active site inhibitors were successfully synthesized, then incorporated into a combinatorial library based on a peptidomimetic beta-strand template.
authors.affiliation: Molecumetics Ltd., 2023 120th Ave. N.E., Bellevue, WA 98005-2199, USA.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yan
authors.forename: Michael
authors.initials: M
authors.lastname: Kahn
authors.forename: Maher
authors.initials: M
authors.lastname: Qabar
authors.forename: Jan
authors.initials: J
authors.lastname: Urban
authors.forename: Hwa-Ok
authors.initials: HO
authors.lastname: Kim
authors.forename: Mark A
authors.initials: MA
authors.lastname: Blaskovich
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D019151:Peptide Library; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000494:pharmacology; D019000:Phosphotyrosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D017433:Protein Structure, Secondary; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D019151:Peptide Library; D019000:Phosphotyrosine; D010649:Phenylalanine; D017027:Protein Tyrosine Phosphatases