title: Modeling protein complexes with BiGGER.
abstract: This article describes the method and results of our participation in the Critical Assessment of PRediction of Interactions (CAPRI) experiment, using the protein docking program BiGGER (Bimolecular complex Generation with Global Evaluation and Ranking) (Palma et al., Proteins 2000;39:372-384). Of five target complexes (CAPRI targets 2, 4, 5, 6, and 7), only one was successfully predicted (target 6), but BiGGER generated reasonable models for targets 4, 5, and 7, which could have been identified if additional biochemical information had been available.
authors.affiliation: REQUIMTE, Departamento de Química, Centro de Química Fina e Biotecnologia, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Monte de Caparica, Portugal. ludi@dq.fct.unl.pt ludik@netcabo.pt
authors.forename: Ludwig
authors.initials: L
authors.lastname: Krippahl
authors.forename: José J
authors.initials: JJ
authors.lastname: Moura
authors.forename: P Nuno
authors.initials: PN
authors.lastname: Palma
mesh_terms: D000465:Algorithms; D000818:Animals; D001665:Binding Sites; D046911:Macromolecular Substances; D008958:Models, Molecular; D025941:Protein Interaction Mapping; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D046911:Macromolecular Substances; D011506:Proteins