[Effects of epimedium total flavonoids phytosomes on preventing and treating bone-loss of ovariectomized rats].
OBJECTIVE
To observe the effects of Epimedium total Flavonoids Phytosomes on preventing and treating bone-loss of the castrate osteoporosis rat model.


METHODS
The osteoporosis model was established with 4-month-odl panther's rats, their ovaries on both sides castrated. Dual energy X-ray scanning was used to determine the bone density, and immunity and ELASA were used to assay concentration of estradiol and IL-6 in serum respectively, then determine their effect.


RESULTS
The BMP and E2 of high dosage group nilestriol group and normal group are higher than those of model group (P < 0.01), while their content of IL-6 is apparently lower than that of model group(P < 0.01).


CONCLUSIONS
The osteoporosis model was established successfully and the using of EFP can improve the bone density, enhance E2 level and decrease the IL-6 concentration in serum.
Jiang
Yong-nan
YN
Guangzhou Railway Central Hospital, Guangzhou 510080, Guangdong, China. jyn21967@163.net
Mo
Hong-ying
HY
Chen
Ji-min
JM
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D004337:Drug Carriers; D034181:Epimedium / Q000737:chemistry*; D004958:Estradiol / Q000097:blood; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D015850:Interleukin-6 / Q000097:blood; D010024:Osteoporosis / Q000097:blood / Q000188:drug therapy / Q000517:prevention & control*; D010052:Ovariectomy; D010743:Phospholipids; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley
D004337:Drug Carriers; D005419:Flavonoids; D015850:Interleukin-6; D010743:Phospholipids; D004958:Estradiol