title: Airborne allergic contact dermatitis from 3-iodo-2-propynyl-butylcarbamate at a paint factory.
abstract: 3-Iodo-2-propynyl-butylcarbamate (IPBC) is a fungicide used in both industrial products and cosmetics. We report the first case of allergic contact dermatitis from airborne exposure to this preservative. A 34-year-old female production worker at a paint factory developed dermatitis on air-exposed skin areas. Patch testing showed a ++ reaction to the preservative IPBC 0.01% in petrolatum. The compound was used as a preservative in wood treatment products manufactured at her work place. Based on animal studies, IPBC is considered safe as a cosmetic preservative. However, widespread use of the chemical might lead to increasing levels of contact allergy, and therefore, close monitoring of IPBC is recommended.
authors.affiliation: Department of Dermatology, Odense University Hospital, University of Southern Denmark and National Allergy Research Centre, Gentofte, Denmark. charlotte.devantier.jensen@ouh.fyns-amt.dk
authors.forename: Charlotte Devantier
authors.initials: CD
authors.lastname: Jensen
authors.forename: Jens
authors.initials: J
authors.lastname: Thormann
authors.forename: Klaus Ejner
authors.initials: KE
authors.lastname: Andersen
mesh_terms: D000328:Adult; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D000485:Allergens / Q000009:adverse effects*; D002219:Carbamates / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D009783:Dermatitis, Occupational / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D010150:Paint / Q000009:adverse effects; D010328:Patch Tests; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*
chemical_list: D000485:Allergens; D002219:Carbamates; D011310:Preservatives, Pharmaceutical; C106572:3-iodo-2-propynylbutylcarbamate