T cell lymphoma associated with myelofibrosis.
Myelofibrosis is most frequently associated with certain primary myeloproliferative disorders,but is rare in lymphoid neoplasms. We report the fourth case associated with T-cell lymphoma, involving bone marrow, lymph nodes and spleen. Marked extramedullary hematopoiesis was present. Myelofibrosis subsided completely with response to standard anti-lymphoma combination chemotherapy. Since lymphomatous splenic and bone marrow involvement was minimal in our patient, fibrotic bone marrows should be carefully evaluated for lymphoma.
Rao
Sujatha A
SA
Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Gottesman
Susan R S
SR
Nguyen
Min C
MC
Braverman
Albert S
AS
D001706:Biopsy; D001853:Bone Marrow / Q000378:metabolism; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000150:complications* / Q000473:pathology; D013154:Spleen / Q000378:metabolism