title: Evolution of serum phosphate in long intermittent hemodialysis.
abstract: BACKGROUND
  Phosphate (P) control is crucial to prevent secondary hyperparathyroidism and extraosseous calcification. Hemodialysis techniques normally used do not remove the amount of P absorbed from an adequate protein intake. Our long hemodialysis (LHD) procedure produces greater P removal in a seven-hour session than in a conventional four-hour session. Our aim was to assess the evolution of predialysis serum P and Ca x P product in patients on intermittent LHD during the first two years on this dialysis schedule.
  
  
  METHODS
  Eight irregular compliant patients underwent LHD for 12 months; five of them completing 24 months. In the conventional hemodialysis (CHD) period, session time was 12 hours per week, while it was 21 hours per week in LHD. We compared P and Ca x P product throughout both periods; each patient was his or her own control.
  
  
  RESULTS
  Mean serum P improved from 7.1 +/- 1.1 mg/dL in CHD to 5.6 +/- 1.1 mg/dL during the second year on LHD (P < 0.05). Mean Ca x P product decreased from 64 +/- 12.7 mg2/dL2 during CHD to 50.9 +/- 10.3 mg2/dL2 at the end of the second year of LHD.
  
  
  CONCLUSIONS
  By prolonging dialysis time to 21 hours per week, better P serum control and lower Ca x P product were achieved in our patients.
authors.affiliation: Centro de Dialisis Uruguayana, Montevideo, Uruguay.
authors.forename: Laura
authors.initials: L
authors.lastname: Fajardo
authors.forename: Nieves
authors.initials: N
authors.lastname: Campistrús
authors.forename: Pablo
authors.initials: P
authors.lastname: Ríos
authors.forename: Teresa
authors.initials: T
authors.lastname: Gómez
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood*; D006435:Renal Dialysis / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D010281:Parathyroid Hormone; D010710:Phosphates; D000469:Alkaline Phosphatase; D002118:Calcium