[Small doses of X-ray irradiation activate the NO-synthase component of the nitric oxide cycle].
It has been shown that chronic X-ray irradiation, (CRI), activates the formation of NO in rats. This is apparent in the increase in the level of NO2- in the blood plasma from 12.59 +/- 1.7 to 39.79 +/- 2.9 nmol/ml after 10 days of irradiation. On the 20 and 30 day of CRI, the level of NO2(-)- was 21.05 +/- 1.2 and 30.73 +/- 1.9 nmol/ml respectively. The changes in the NO-synthase component of the NO cycle were accompanied by a decrease in the osmotic resistance of the erythrocytes and the nitritreductase activity of hemoglobin.
Korobov
V N
VN
Institute of Physical Optics, Lviv, 79005 Ukraine. vn_korobov@mail.ru
Sorokina
L V
LV
Korobova
O V
OV
Datsiuk
L A
LA
D000222:Adaptation, Physiological; D000818:Animals; D002478:Cells, Cultured; D004912:Erythrocytes / Q000378:metabolism / Q000528:radiation effects*; D006454:Hemoglobins / Q000378:metabolism / Q000528:radiation effects; D006461:Hemolysis / Q000528:radiation effects; D008297:Male; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000097:blood / Q000378:metabolism*; D009572:Nitrite Reductases / Q000097:blood; D009995:Osmosis; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors
D006454:Hemoglobins; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D009572:Nitrite Reductases