Toll and Toll-like receptors in Drosophila.
The Drosophila Toll receptor controls the immune response to Gram-positive bacteria and fungi by activating a signalling pathway partially conserved throughout evolution. The Drosophila genome encodes eight additional Toll-related receptors, most of which appear to carry out developmental rather than immune functions. One exception may be Toll-9, which shares structural and functional similarities with mammalian TLRs.
Bilak
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UPR9022 CNRS, 15 rue René Descartes, 67084 Strasbourg Cedex, France.
Tauszig-Delamasure
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Imler
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D000818:Animals; D005075:Biological Evolution; D004330:Drosophila / Q000235:genetics / Q000276:immunology* / Q000382:microbiology*; D029721:Drosophila Proteins; D005658:Fungi / Q000472:pathogenicity; D016678:Genome; D006090:Gram-Negative Bacteria / Q000472:pathogenicity; D006094:Gram-Positive Bacteria / Q000472:pathogenicity; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology*; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors
D029721:Drosophila Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors; C495341:tehao protein, Drosophila