title: Efficacy of intramammary treatment with procaine penicillin G vs. procaine penicillin G plus neomycin in bovine clinical mastitis caused by penicillin-susceptible, gram-positive bacteria--a double blind field study.
abstract: The efficacy of intramammary treatments containing procaine penicillin G alone (treatment A) or a combination of procaine penicillin G and neomycin (treatment B) was compared in treating clinical bovine mastitis caused by gram-positive bacteria susceptible in vitro to penicillin G. Both treatments were supplemented with a single intramuscular injection of procaine penicillin G on the first day of treatment. The study was carried out using a double blind design on commercial dairy farms in Southern Finland. A total of 56 quarters were treated with treatment A and 61 with treatment B. The cure rates for both treatments were equal, which suggests that the use of the penicillin G-aminoglycoside combination does not increase the efficacy of the treatment over that achieved by using penicillin G alone in bovine clinical mastitis caused by penicillin-susceptible, gram-positive bacteria.
authors.affiliation: Faculty of Veterinary Medicine, Department of Clinical Veterinary Sciences, University of Helsinki, Saarentaus, Finland. suvi.taponen@helsinki.fi
authors.forename: S
authors.initials: S
authors.lastname: Taponen
authors.forename: K
authors.initials: K
authors.lastname: Dredge
authors.forename: B
authors.initials: B
authors.lastname: Henriksson
authors.forename: A-M
authors.initials: AM
authors.lastname: Pyyhtiä
authors.forename: L
authors.initials: L
authors.lastname: Suojala
authors.forename: R
authors.initials: R
authors.lastname: Junni
authors.forename: K
authors.initials: K
authors.lastname: Heinonen
authors.forename: S
authors.initials: S
authors.lastname: Pyörälä
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002417:Cattle; D003612:Dairying; D004311:Double-Blind Method; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006094:Gram-Positive Bacteria / Q000187:drug effects; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D007267:Injections / Q000662:veterinary; D008414:Mastitis, Bovine / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D008826:Microbial Sensitivity Tests; D009355:Neomycin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010402:Penicillin G Procaine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010406:Penicillins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D010402:Penicillin G Procaine; D009355:Neomycin