Neonatal alloimmune thrombocytopenia may be less severe in a subsequent pregnancy.
Neonatal alloimmune thrombocytopenia (NAIT) is more common than previously appreciated. Clinical presentation is varied, but it is generally a severe disorder and it is said to be more severe in subsequent pregnancies. The authors present a case of fatal disseminated intravascular coagulation that was diagnosed as NAIT only after presentation of a subsequent surviving sibling with intracranial hemorrhage and thrombocytopenia. Despite the perinatal complications, this second sibling had good neurodevelopmental outcome. This is the first reported case of less severe disease occurring in a subsequent pregnancy.
Groves
A M
AM
Department of Paediatrics, Sunderland Royal Hospital, Sunderland, UK. grovesalan@hotmail.com
Clough
V
V
Stevens
R
R
D000328:Adult; D001792:Blood Platelets; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000209:etiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011696:Purpura, Thrombocytopenic / Q000209:etiology; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology*