title: Age-dependent changes in electroencephalographic responses to alcohol consumption in subjects with aldehyde dehydrogenase-2 genetic variations.
abstract: BACKGROUND
  We have recently reported that alcohol consumption resulted in a significant increase in alpha power of the EEGs in aldehyde dehydrogenase-2 (ALDH2)-normal (NN) subjects but not in ALDH2-deficient heterozygote (ND) subjects. The purpose of the present study was to investigate interactive effects of individual factors such as age and ALDH2 genotype on alcohol-induced EEG changes.
  
  
  METHODS
  We examined EEG power spectral changes induced by 0.4 ml/kg of alcohol ingestion in 53 NN and 21 ND subjects of two different age groups: younger and older groups. Blood ethanol and acetaldehyde levels were also determined in 17 NN and 13 ND subjects in separate studies.
  
  
  RESULTS
  Alcohol consumption markedly increased EEG power in the NN subjects of the older group, especially in theta and slow alpha power, whereas only slight increases were noted in fast alpha and beta power in the NN subjects of the younger group. However, no such differences between the two age groups were observed in the ND subjects. It should be noted that there were no differences in blood ethanol and acetaldehyde level at 30 min after alcohol ingestion between the different age groups in both genotypes. However, there was a significant increase in frequency of alcohol intake in the older group of both genotype groups. The multiple regression analysis indicated that both alcohol use habits and genotype, as well as aging, significantly modulated EEG changes after alcohol ingestion.
  
  
  CONCLUSIONS
  The results suggest that both ALDH2 genotype and age as well as alcohol use habits modify alcohol sensitivity in the central nervous system, resulting in greater increases in EEG energy in response to alcohol intake in the older group of the NN subjects.
authors.affiliation: Central Laboratories for Key Technology, Kirin Brewery Co. Ltd., 1-3-5 Fukuura, Kanazawa, Yokohama, Kanagawa 236-0004, Japan. nfusae@kirin.co.jp
authors.forename: Fusae T
authors.initials: FT
authors.lastname: Nishimura
authors.forename: Tatsushige
authors.initials: T
authors.lastname: Fukunaga
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Yokomukai
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kajiura
authors.forename: Taketoshi
authors.initials: T
authors.lastname: Ono
authors.forename: Hisao
authors.initials: H
authors.lastname: Nishijo
mesh_terms: D000079:Acetaldehyde / Q000097:blood; D000328:Adult; D000375:Aging / Q000502:physiology*; D000428:Alcohol Drinking / Q000009:adverse effects*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D004569:Electroencephalography; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D012044:Regression Analysis; D012677:Sensation / Q000187:drug effects
chemical_list: D000431:Ethanol; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000079:Acetaldehyde