title: Allergic diseases, drug adverse reactions and total immunoglobulin E levels in lupus erythematosus patients.
abstract: BACKGROUND
  The association of allergic diseases, drug adverse reactions and elevated total immunoglobulin E (IgE) concentration in systemic lupus erythematosus patients remains controversial. The aim of the study was to investigate the prevalence of those features in active and inactive systemic lupus erythematosus patients, and in the control group as well.
  
  
  METHODS
  Total IgE concentration was evaluated by enzyme-linked immunosorbent assay.
  
  
  CONCLUSIONS
  The results of our study revealed that concomitant allergic diseases were not more frequent in systemic lupus erythematosus patients than in the general population. Total IgE concentration was significantly higher during the active stage of the disease. Drug reactions were very frequent but not connected with IgE elevation. Our results indicate that IgE may play a role in lupus pathogenesis, especially in the active phase of the disease.
authors.affiliation: Department of Dermatology, Medical University of Lodz, Krzemieniecka 5, 94-017 Lodz, Poland. wozniacka@bmp.net.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Wozniacka
authors.forename: Anna
authors.initials: A
authors.lastname: Sysa-Jedrzejowska
authors.forename: Ewa
authors.initials: E
authors.lastname: Robak
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Samochocki
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Zak-Prelich
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D004342:Drug Hypersensitivity / Q000453:epidemiology* / Q000276:immunology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence
chemical_list: D007073:Immunoglobulin E