Biarylpyrimidines: a new class of ligand for high-order DNA recognition.
Biarylpyrimidines bearing omega-aminoalkyl substituents have been designed as ligands for high-order DNA structures: spectrophotometric, thermal and competition equilibrium dialysis assays showed that changing the functional group for substituent attachment from thioether to amide switches the structural binding preference from triplex to tetraplex DNA; the novel ligands are non-toxic and moderate inhibitors of human telomerase.
Murphy
Peter M
PM
School of Pharmacy, University of Bradford, Bradford, West Yorkshire, UK BD7 1DP.
Phillips
Victoria A
VA
Jennings
Sharon A
SA
Garbett
Nichola C
NC
Chaires
Jonathan B
JB
Jenkins
Terence C
TC
Wheelhouse
Richard T
RT
D004247:DNA / Q000737:chemistry*; D006358:Hot Temperature; D008024:Ligands; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D011743:Pyrimidines / Q000737:chemistry*
D008024:Ligands; D011743:Pyrimidines; C051802:triplex DNA; D004247:DNA