title: Effect of Levovist on splanchnic hemodynamics in cirrhotic patients.
abstract: This study was aimed to assess the effect of Levovist on Doppler parameters of splanchnic hemodynamics. A total of 12 patients with cirrhosis and 12 healthy subjects underwent Doppler ultrasound (US) examination of the portal vein and of the hepatic, splenic and superior mesenteric arteries before, 5 to 8 and 12 to 15 min after the start of an 8-min long IV infusion of 2.5 g of Levovist. Mean velocity and mean diameter were calculated for the portal vein. Resistance index was determined for the arteries. A significant increase of resistance index was observed in the hepatic (0.80 +/- 0.07 vs. 0.71 +/- 0.06; p < 0.01) and splenic arteries (0.72 +/- 0.06 vs. 0.64 +/- 0.06; p < 0.01) 5 to 8 min after contrast agent injection in patients with cirrhosis, but not in controls. Neither portal vein diameter nor portal flow mean velocity changed during the test in both controls and cirrhotic patients. This effect might be related to a selective trapping of microbubbles in the altered hepatic and splenic microvasculature in patients with cirrhosis rather than being artefactual. It might have implications on harmonic imaging US protocols designed to image the cirrhotic liver in the early arterial phase.
authors.affiliation: Dipartimento di Medicina Interna e Gastroenterologia, Università degli Studi di Bologna, Bologna, Italy. sgaiani@med.unibo.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Gaiani
authors.forename: Carla
authors.initials: C
authors.lastname: Serra
authors.forename: Fabio
authors.initials: F
authors.lastname: Piscaglia
authors.forename: Natascia
authors.initials: N
authors.lastname: Celli
authors.forename: Leonardo
authors.initials: L
authors.lastname: Rasciti
authors.forename: Mario
authors.initials: M
authors.lastname: Miglioli
authors.forename: Luigi
authors.initials: L
authors.lastname: Bolondi
mesh_terms: D000368:Aged; D003287:Contrast Media / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006499:Hepatic Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides / Q000494:pharmacology*; D013152:Splanchnic Circulation / Q000187:drug effects*; D013157:Splenic Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D018608:Ultrasonography, Doppler; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508