Extracellularly applied Br-TITU inhibits the Na+/K+ pump by interacting with tryptophan at the entrance to the cation sites.
Yudowski
G A
GA
Laboratorio de Biofisica, Instituto M. y M. Ferreyra, 5000 Córdoba, Argentina. gyudowski@immf.uncor.edu
Shimon
M Bar
MB
González-Lebrero
R M
RM
Rossi
R C
RC
Garrahan
P J
PJ
Karlish
S J D
SJ
Beaugé
L
L
D001665:Binding Sites; D002412:Cations / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D007550:Isothiuronium / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007700:Kinetics; D010042:Ouabain / Q000494:pharmacology; D012964:Sodium / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors* / Q000097:blood / Q000737:chemistry; D014364:Tryptophan
C108416:1,3-dibromo-2,4,6-tris-(methylisothiouronium)benzene; D002412:Cations; D004791:Enzyme Inhibitors; D007550:Isothiuronium; D010042:Ouabain; D014364:Tryptophan; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase