Hypervalent iodine mediated synthesis of 1-aryl/hetryl-1,2,4-triazolo[4,3-a] pyridines and 1-aryl/hetryl 5-methyl-1,2,4-triazolo[4,3-a]quinolines as antibacterial agents.
Oxidation of 2-pyridyl and 2-quinylhydrazones with iodobenzene diacetate (IBD) in dichloromethane yield 1-aryl/hetryl-1,2,4-trizolo-[4,3-a] pyridines (3a-f) and 1-aryl/hetryl-5-methyl-1,2,4-triazolo[4,3-a] quinolines (6a-f). Seven compounds were tested in vitro for their antibacterial activity. 1-(5'-Nitro-2-furyl)-5-methyl-1,2,4-triazolo[4,3-a]quinoline (6e) was associated with substantially higher antibacterial activity than some commercial antibiotics against Salmonella typhi at MIC i.e. 10 microg mL(-1).
Sadana
Anil K
AK
Department of Chemistry, Kurukshetra University, Kurukshetra 136119, India. sadana@rice.edu
Mirza
Yasmin
Y
Aneja
Kamal R
KR
Prakash
Om
O
D000085:Acetates / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects; D007462:Iodobenzenes / Q000737:chemistry*; D007778:Lactobacillus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012485:Salmonella typhi / Q000187:drug effects
D000085:Acetates; D000900:Anti-Bacterial Agents; D007462:Iodobenzenes; D011725:Pyridines; D011804:Quinolines