title: Molecular targets of hyperphosphataemia in chronic renal failure.
abstract: Dietary phosphate restriction can prevent or retard the progress of chronic renal failure (CRF) and secondary hyperparathyroidism. The klotho gene is involved in the development of a syndrome resembling human ageing, and klotho mutant mice show abnormal calcium/vitamin D metabolism, developing hyperphosphataemia and vascular calcification. Phosphate retention rescues the phenotype of klotho mice. The level of expression of klotho RNA was greatly reduced in the kidneys of all CRF patients. Dietary P(i) restriction induced klotho expression, which enhances the beneficial effect of P(i) restriction in patients with CRF and/or on haemodialysis.
authors.affiliation: Department of Nutrition, School of Medicine, Tokushima University, Japan.
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Mikiko
authors.initials: M
authors.lastname: Ito
authors.forename: Hiriko
authors.initials: H
authors.lastname: Segawa
authors.forename: Masashi
authors.initials: M
authors.lastname: Kuwahata
mesh_terms: D000818:Animals; D015870:Gene Expression; D005966:Glucuronidase; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D000090265:Klotho Proteins; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics; D010641:Phenotype; D010760:Phosphorus Metabolism Disorders / Q000209:etiology* / Q000235:genetics*; D012313:RNA / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; D012313:RNA; D005966:Glucuronidase; D000090265:Klotho Proteins