title: Pulmonary veno-occlusive disease after autologous bone marrow transplant in a child with stage IV neuroblastoma: case report and literature review.
abstract: Pulmonary veno-occlusive disease (PVOD) is a rare, almost universally fatal complication of chemotherapy and bone marrow transplantation with few treatment options. A 19-month-old boy with stage 4 neuroblastoma with fatal PVOD following high-dose chemotherapy with autologous peripheral blood stem cell rescue is described here. A comprehensive literature review revealed 40 case reports of PVOD in oncology patients. Various therapeutic modalities were attempted, with four survivors. PVOD should be considered in patients with dyspnea and cardiomegaly. Less invasive diagnostic methods and more effective therapies are needed.
authors.affiliation: Section of Pediatric Hematology/Oncology/Bone Marrow Transplantation, Children's Hospital of Denver, Colorado, USA.
authors.forename: Angela D
authors.initials: AD
authors.lastname: Trobaugh-Lotrario
authors.forename: Brian
authors.initials: B
authors.lastname: Greffe
authors.forename: Robin
authors.initials: R
authors.lastname: Deterding
authors.forename: Gail
authors.initials: G
authors.lastname: Deutsch
authors.forename: Ralph
authors.initials: R
authors.lastname: Quinones
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000150:complications* / Q000209:etiology* / Q000473:pathology; D011668:Pulmonary Veno-Occlusive Disease / Q000150:complications* / Q000209:etiology* / Q000473:pathology; D014182:Transplantation, Autologous / Q000009:adverse effects