The fate of the prion protein in the prion/plasminogen complex.
The cellular prion protein (PrP(c)) forms complexes with plasminogen. Here, we show that the PrP(c) in this complex is cleaved to yield fragments of PrP(c). The cleavage is accelerated by plasmin but does not appear to be dependent on it.
Kornblatt
Jack A
JA
Concordia University, 1455 de Maisonneuve Blvd., Montreal, Qc, Canada H3G 1M8. krnbltt@vax2.concordia.ca
Marchal
Stephane
S
Rezaei
Human
H
Kornblatt
M Judith
MJ
Balny
Claude
C
Lange
Reinhard
R
Debey
Marie-Pascale
MP
Hui Bon Hoa
Gaston
G
Marden
Michael C
MC
Grosclaude
Jeanne
J
D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D005341:Fibrinolysin / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances; D010446:Peptide Fragments / Q000378:metabolism; D010958:Plasminogen / Q000378:metabolism*; D018621:PrPC Proteins / Q000378:metabolism*; D012756:Sheep; D010959:Tissue Plasminogen Activator / Q000378:metabolism
D046911:Macromolecular Substances; D010446:Peptide Fragments; D018621:PrPC Proteins; D010958:Plasminogen; D010959:Tissue Plasminogen Activator; D005341:Fibrinolysin