title: ICM0201, a new inhibitor of osteoclastogenesis from Cunninghamella sp. F-1490. I. Taxonomy, fermentation, isolation and biological activities.
abstract: In the course of screening for inhibitors of osteoclastogenesis, a new substance designated as ICM0201 was isolated from a fermentation broth of Cunninghamella sp. F-1490. ICM0201 inhibited the formation of osteoclasts in mouse bone marrow cells with an IC50 value of 0.78 microg/ml and showed weak cytotoxicity against bone marrow cells.
authors.affiliation: Institute for Chemotherapy, M. C. R. F., 18-24 Miyamoto, Numazu-shi, Shizuoka, 410-0301, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inoue
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kumagai
authors.forename: Michiyo
authors.initials: M
authors.lastname: Osono
authors.forename: Motoko
authors.initials: M
authors.lastname: Matsufuji
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sameshima
authors.forename: Naoto
authors.initials: N
authors.lastname: Kawamura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Someno
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ishizuka
authors.forename: Tomio
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000145:classification* / Q000302:isolation & purification / Q000494:pharmacology; D020093:Cunninghamella / Q000737:chemistry*; D005285:Fermentation; D006575:Heterocyclic Compounds, 3-Ring / Q000145:classification* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010078:Oxazines / Q000145:classification* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D006575:Heterocyclic Compounds, 3-Ring; C474716:ICM 0201; D010078:Oxazines