Expression of Heparin-Binding Epidermal Growth Factor-like Growth Factor in Pancreatic Adenocarcinoma.
Heparin-binding epidermal growth factor-likegrowth factor (HB-EGF) belongs to the EGF familyand was originally identified in the conditionedmedium of a human histiotic lymphoma cell line, U937 (1). This protein is synthesized as a preproformof 208 amino acids (2), is expressed as amembrane-anchored HB-EGF, and is released as asoluble form of 87 amino acids after being processedby protease (1,2). HB-EGF binds to the EGF receptor(EGF-R) in competition with EGF (3), and exogenoussoluble HB-EGF is known to stimulateDNA synthesis in primary rat hepatocytes in a dosedependentmanner (4).
Ito
Yasuhiro
Y
Department of Surgery, Osaka Seamen's Insurance Hospital, 1-8-30, Chikko, Minato-ku, Osaka 552-0021, Japan; Department of Pathology, Osaka University Faculty of Medicine, 1-7, Yamadaoka, Suita, Osaka 565-0871, Japan.
Higashiyama
Shigeki
S
Takeda
Tsutomu
T
Yamamoto
Yasuko
Y
Wakasa
Ken-Ichi
KI
Matsuura
Nariaki
N