Thyroid hormone-induced sulfate absorption in Aplysia californica gut is mediated by protein synthesis.
Mucosal membranes of foregut epithelia of Aplysia californica contain a sodium-sulfate symporter that is stimulated by triiodothyronine. Actinomycin D, puromycin, or cycloheximide inhibited the triiodothyronine-stimulated sulfate absorption. It appears that thyroid hormone manifests its effects on sulfate absorption in the A. californica gut through protein synthesis.
Gerencser
George A
GA
Department of Physiology & Functional Genomics, College of Medicine, Box 100274 JHMHC, University of Florida, Gainesville, FL 32610, USA. gag@phys.med.ufl.edu
Loo
Stanley Y
SY
Zhang
Jianliang
J
D000818:Animals; D001048:Aplysia / Q000378:metabolism*; D025461:Feedback, Physiological / Q000187:drug effects / Q000502:physiology; D007408:Intestinal Absorption / Q000187:drug effects* / Q000502:physiology; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000502:physiology*; D014176:Protein Biosynthesis; D013431:Sulfates / Q000378:metabolism*; D027981:Symporters / Q000187:drug effects / Q000378:metabolism; D014284:Triiodothyronine / Q000494:pharmacology*
D013431:Sulfates; D027981:Symporters; D014284:Triiodothyronine