Clearance of 14-3-3 protein from cerebrospinal fluid heralds the resolution of bacterial meningitis.
The 14-3-3 protein, a cerebrospinal fluid (CSF) marker of neuronal damage that was recently adopted for the diagnosis of Creutzfeldt-Jakob disease, is also found in the CSF of patients with a variety of neurological disorders. We prospectively studied 12 consecutive patients with purulent bacterial meningitis and found that 14-3-3 protein was detected in all patients at admission to the hospital. All patients who recovered cleared 14-3-3 protein from the CSF before discharge from the hospital (this was the first CSF marker to clear), whereas those who died never cleared the protein.
Bonora
Stefano
S
Department of Infectious Diseases, University of Turin, Turin, Italy.
Zanusso
Gianluigi
G
Raiteri
Riccardo
R
Monaco
Salvatore
S
Rossati
Antonella
A
Ferrari
Sergio
S
Boffito
Marta
M
Audagnotto
Sabrina
S
Sinicco
Alessandro
A
Rizzuto
Nicola
N
Concia
Ercole
E
Di Perri
Giovanni
G
D048948:14-3-3 Proteins; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002556:Cerebrospinal Fluid Proteins / Q000134:cerebrospinal fluid*; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid; D006801:Humans; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid* / Q000401:mortality; D011379:Prognosis; D011446:Prospective Studies; D014446:Tyrosine 3-Monooxygenase / Q000134:cerebrospinal fluid*
D048948:14-3-3 Proteins; D015415:Biomarkers; D002556:Cerebrospinal Fluid Proteins; D014446:Tyrosine 3-Monooxygenase