title: Direct access of drugs to the human brain after intranasal drug administration?
abstract: It has been suggested that intranasal (IN) drug delivery could be used to administer drugs directly to the brain, bypassing the blood-brain barrier. Conclusive evidence of this proposed route of drug transport has not been observed by IN-IV comparison. In eight neurosurgery patients with a CSF drain, the uptake in CSF and plasma after IN and IV drug administration was compared. No evidence of direct access of the drugs from the nose to the CSF was found.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Academic Medical Center, University of Amsterdam, The Netherlands. P.Merkus@VUmc.nl
authors.forename: Paul
authors.initials: P
authors.lastname: Merkus
authors.forename: Henk-Jan
authors.initials: HJ
authors.lastname: Guchelaar
authors.forename: D Andries
authors.initials: DA
authors.lastname: Bosch
authors.forename: Frans W H M
authors.initials: FW
authors.lastname: Merkus
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D006879:Hydroxocobalamin / Q000008:administration & dosage* / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics; D007275:Injections, Intravenous; D008297:Male; D008550:Melatonin / Q000008:administration & dosage* / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics; D008875:Middle Aged
chemical_list: D008550:Melatonin; D006879:Hydroxocobalamin