title: Tick-borne encephalitis with hemorrhagic syndrome, Novosibirsk region, Russia, 1999.
abstract: Eight fatal cases of tick-borne encephalitis with an unusual hemorrhagic syndrome were identified in 1999 in the Novosibirsk Region, Russia. To study these strains, we sequenced cDNA fragments of protein E gene from six archival formalin-fixed brain samples. Phylogenetic analysis showed tick-borne encephalitis variants clustered with a Far Eastern subtype (homology 94.7%) but not with the Siberian subtype (82%).
authors.affiliation: State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Novosibirsk Region, Russia. loktev@vector.nsc.ru
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Ternovoi
authors.forename: Gennady P
authors.initials: GP
authors.lastname: Kurzhukov
authors.forename: Yuri V
authors.initials: YV
authors.lastname: Sokolov
authors.forename: Gennady Y
authors.initials: GY
authors.lastname: Ivanov
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Ivanisenko
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Loktev
authors.forename: Robert W
authors.initials: RW
authors.lastname: Ryder
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Netesov
authors.forename: Valery B
authors.initials: VB
authors.lastname: Loktev
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004285:Dogs; D004669:Encephalitis Viruses, Tick-Borne / Q000302:isolation & purification; D004675:Encephalitis, Tick-Borne / Q000453:epidemiology* / Q000821:virology*; D006470:Hemorrhage / Q000453:epidemiology* / Q000821:virology*; D006482:Hemorrhagic Fevers, Viral / Q000175:diagnosis; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D010802:Phylogeny; D012426:Russia / Q000453:epidemiology; D013577:Syndrome; D013997:Time Factors