title: A novel anthracenyl tagged protecting group for "phase-switching" applications in parallel synthesis.
abstract: A new "phase-switching" protecting group 1 that facilitates the parallel synthesis of carboxylic acids, esters, and carboxamides is described. Its use permits chemistries to be performed in solution, which may be conveniently monitored with conventional analytical techniques, followed by subsequent immobilization onto a solid-phase support to aid compound purification. Carboxylic acids, esters, and carboxamides are then cleaved from the solid support following activation of the "safety-catch" and treatment with the desired nucleophile.
authors.affiliation: University Chemical Laboratory, University of Cambridge, Lensfield Road, UK.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Chris
authors.initials: C
authors.lastname: Abell
authors.forename: Mark
authors.initials: M
authors.lastname: Ladlow