[Effects of the active components of some Chinese herbs on drug metabolizing-enzymes].
OBJECTIVE
To review the effects of the active components of Chinese herbs on drug metabolizing-enzymes.


METHODS
Relevant research papers reported in recent years were consulted and studied.


RESULTS
The drug metabolizing-enzymes cytochrome P450 and UDP-glucuronosyl transferase and glutathione S-transferase were inhibited or induced by the flavonoids, furocoumarins, and the active components extracted from salvia miltiorrhiza and hypericum perforatum, and so on, which therefore slowed or sped metabolism of other drugs in vivo and in vitro.


CONCLUSIONS
Much attention should be paid to the metabolic interaction of the Chinese herbs when coadministered with other drugs.
Yang
Xiu-fen
XF
Department of Clinical Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. xiufenyang@163.net
Wang
Nai-ping
NP
Zeng
Fan-dian
FD
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D011564:Furocoumarins / Q000302:isolation & purification / Q000494:pharmacology*; D014453:Glucuronosyltransferase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D010946:Plants, Medicinal / Q000737:chemistry*; D027561:Salvia miltiorrhiza / Q000737:chemistry
D005419:Flavonoids; D011564:Furocoumarins; D003577:Cytochrome P-450 Enzyme System; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase