title: New sesquiterpene quinols from a Micronesian sponge, Aka sp.
abstract: Three new sesquiterpene quinols (1, 2, and 5) and two known ones (3 and 4) were isolated along with halistanol sulfate (6) from a marine sponge of the genus Aka collected from Yap Island, Federated States of Micronesia. Their structures were determined from spectral data, and the structure of siphonodictyal C (3) was revised. Sulfates 3 and 6 inhibit CDK4/cyclin D1 complexation, whereas 1 and 4 do not.
authors.affiliation: Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019, USA.
authors.forename: Venugopal J R V
authors.initials: VJ
authors.lastname: Mukku
authors.forename: Ru A
authors.initials: RA
authors.lastname: Edrada
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Schmitz
authors.forename: Michelle Kelly
authors.initials: MK
authors.lastname: Shanks
authors.forename: Babathosh
authors.initials: B
authors.lastname: Chaudhuri
authors.forename: Doriano
authors.initials: D
authors.lastname: Fabbro
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D019938:Cyclin D1 / Q000187:drug effects; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008849:Micronesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D011518:Proto-Oncogene Proteins; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D011518:Proto-Oncogene Proteins; D012717:Sesquiterpenes; D019938:Cyclin D1; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases