Cortical interneuron fate determination: diverse sources for distinct subtypes?
GABAergic interneurons perform crucial roles in cortical development and function. These roles are executed by a diversity of interneuron subtypes, and abnormal function of particular subtypes has been implicated in a variety of neuropsychiatric diseases. However, little is known about the mechanisms that generate interneuron diversity. This paper discusses the potential origins of interneuron subtypes. Evidence is reviewed that suggests bipolar calretinin expressing interneurons may have distinct origins from those that express parvalbumin or somatostatin. In addition, evidence is presented that migratory cells from the subcortical subventricular zone (SVZ) do not proliferate after migration into the cortical SVZ.
Xu
Qing
Q
Department of Psychiatry and Department of Neurology and Neuroscience, Weill Medical College of Cornell University, Box 244, Room 929A Lasdon, 1300 York Ave., New York, NY 10021, USA.
de la Cruz
Estanislao
E
Anderson
Stewart A
SA
D000818:Animals; D064032:Calbindin 2; D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D007395:Interneurons / Q000145:classification* / Q000166:cytology / Q000502:physiology*; D051379:Mice; D010320:Parvalbumins / Q000378:metabolism; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism
C576511:Calb2 protein, mouse; D064032:Calbindin 2; D010320:Parvalbumins; D064030:S100 Calcium Binding Protein G; D013004:Somatostatin