A new prognostic model for testicular germ cell tumours.
In univariate analyses of patients with metastatic testicular germ cell tumours (TGCT), both the International Germ Cell Consensus Classification (IGCCC) and serum lactate dehydrogenase (S-LD) isoenzyme 1 catalytic concentration (S-LD-1) significantly predicted survival. In complementary analyses of 81 patients with metastatic TGCT, S-LD and S-LD-1 classified the prognosis differently for 23 patients. In multivariate Cox hazard analyses of risk factors, only IGCCC and S-LD-1 predicted the prognosis (p=0.036, and p=0.0007, respectively). A new prognostic model based on prognostic information from main histology, IGCCC, and S-LD-1 changed the prognostic prediction by IGCCC for 19 patients (24%). Judged by to the area under the curve for receiver operation characteristics curves, the new model predicted five-years survival for the patients better than IGCCC and a modified version of the third edition of the TNM classification (p=0.025, and p=0.01, respectively). However, new studies should validate the new model before it is recommended as a general classification system of patients with metastatic TGCT.
von Eyben
Finn Edler
FE
Center of Tobacco Research, Odense, Department of Oncology, Soenderborg Hospital, Denmark. feve@post5.tele.dk
Madsen
Ebbe Lindegaard
EL
Fritsche
Herbert
H
Suciu
Gabriel
G
Liu
Frank
F
Amato
Robert
R
D014408:Biomarkers, Tumor / Q000097:blood; D018237:Germinoma / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D016609:Neoplasms, Second Primary / Q000097:blood / Q000175:diagnosis*; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis; D013736:Testicular Neoplasms / Q000097:blood / Q000175:diagnosis*; D013737:Testis / Q000473:pathology
D014408:Biomarkers, Tumor; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase