Telomere replication: an Est fest.
The search for subunits of the telomerase enzyme has uncovered orthologs of the budding years Est1 protein in several species, including humans. Thus, positive regulation of telomerase by Est1 appears to be a widely utilized mechanism for maintaining telomere length homeostasis.
Lundblad
Vicki
V
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. lundblad@bcm.tmc.edu
D000595:Amino Acid Sequence; D006706:Homeostasis / Q000502:physiology*; D008954:Models, Biological; D008969:Molecular Sequence Data; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D016415:Sequence Alignment; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere / Q000378:metabolism / Q000502:physiology*
D029701:Saccharomyces cerevisiae Proteins; C099024:EST1 protein, S cerevisiae; D019098:Telomerase