title: Increased sympathetic response to standing in panic disorder.
abstract: Although autonomic function has been investigated in panic disorder (PD), previous studies have not used non-invasive beat by beat blood pressure (BP) monitoring to assess the rapid dynamics of BP during autonomic reflex tests. The hypothesis of the current study was that patients with PD would show increased cardiovascular sympathetic reactivity compared with healthy or anxious controls, as assessed by the initial overshoot of diastolic BP during the immediate response to standing. Patients with PD (n=56), social phobia (n=28) and healthy volunteers (n=56) were tested using finger photoplethysmography during an orthostatic challenge. Panic disorder patients showed an increased BP overshoot compared with both control groups. Moreover, in a preliminary assessment of selective serotonin reuptake inhibitor treatment effects, the BP overshoot was significantly reduced towards normal values. These findings are consistent with recent evidence for increased sympathetic baroreflex function in PD and may be relevant to the pathophysiology of the disorder.
authors.affiliation: Psychopharmacology Unit, School of Medical Sciences, University Walk, Bristol, UK. nc2@ualberta.ca
authors.forename: Nick J
authors.initials: NJ
authors.lastname: Coupland
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Wilson
authors.forename: John P
authors.initials: JP
authors.lastname: Potokar
authors.forename: Caroline
authors.initials: C
authors.lastname: Bell
authors.forename: David J
authors.initials: DJ
authors.lastname: Nutt
mesh_terms: D000328:Adult; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000188:drug therapy / Q000503:physiopathology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D014666:Vasomotor System / Q000503:physiopathology*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors