title: Magnetic resonance imaging identifies cytoarchitectonic subtypes of the normal human cerebral cortex.
abstract: BACKGROUND
  Magnetic Resonance Imaging (MRI) allows a detailed "in vivo" macroscopic study of the human brain; previously, it has been demonstrated that Fluid Attenuated Inversion Recovery (FLAIR) sequence shows higher signal intensity of cortices belonging to limbic structures.
  
  
  OBJECTIVE
  To measure and compare signal intensities (SI) of cytoarchitectonically different cortical regions.
  
  
  METHODS
  In 22 adult subjects, without psychiatric or neurological diseases, FLAIR sequence was performed in coronal slices, perpendicular to the main hippocampal axis. Signal intensity was measured, with a region-of-interest (ROI) function, in 12 different cortical regions. We compared these values and grouped the cortices into five groups: (1) limbic cortices, (2) paralimbic agranular cortices, (3) paralimbic granular cortices, (4) parietal-type neopallium, (5) frontal-type neopallium. A t-test for comparison of paired samples was performed, considering p</=0.05 as statistically significant.
  
  
  RESULTS
  We found statistically significant differences amongst the different groups, with the exception of groups 1 and 2, which did not show differences between them. No statistically significant differences were found among cortices belonging to the same group.
  
  
  CONCLUSIONS
  Structural characteristics of the cerebral cortex cause changes in its signal intensity. Magnetic resonance imaging (FLAIR sequence) allows discrimination of different cytoarchitectonic areas of the human cerebral cortex.
authors.affiliation: Science and Technology Department, (UBACYT) Buenos Aires University, Paraguay 2155, Buenos Aires, Argentina. mbendersky@intramed.net.ar
authors.forename: Mariana
authors.initials: M
authors.lastname: Bendersky
authors.forename: Carlos
authors.initials: C
authors.lastname: Rugilo
authors.forename: Silvia
authors.initials: S
authors.lastname: Kochen
authors.forename: Gustavo
authors.initials: G
authors.lastname: Schuster
authors.forename: Roberto E P
authors.initials: RE
authors.lastname: Sica
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000502:physiology; D003337:Corpus Callosum / Q000033:anatomy & histology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008032:Limbic System / Q000033:anatomy & histology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed