title: [Relationship of I/D polymorphism of angiotensin converting enzyme gene with hypertension in Xinjiang Kazakh isolated group].
abstract: OBJECTIVE
  To investigate whether the insertion/deletion(I/D) polymorphism in the angiotensin converting enzyme(ACE) gene is associated with essential hypertension in Xinjiang Kazakh isolated population.
  
  
  METHODS
  The study covered 201 hypertensives and 151 normotensive controls in Xinjiang Barlikun Kazakh population. The I/D polymorphism of ACE gene was determined by polymerase chain reaction.
  
  
  RESULTS
  The frequencies of D and I in the hypertensive group (0.44 and 0.56, respectively) were not significantly different from the controls(0.39 and 0.61, respectively, P=0.16). The frequencies of ACE genotypes of DD, ID, and II were 0.18, 0.52, 0.30 in hypertensives respectively and 0.17, 0.43, 0.40 in control group respectively. There was no significant difference in genotypes between hypertensive group and normotensive group (P=0.14).
  
  
  CONCLUSIONS
  The results suggested that the I/D polymorphism of ACE gene might not be associated with hypertension in the Kazakh population of Xinjiang Barlikun area.
authors.affiliation: Department of Cardiac Internal Medicine, the First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, 830054 PR China. wxfjxy22103@hotmail.com
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Wang
authors.forename: Shi-zhen
authors.initials: SZ
authors.lastname: Wang
authors.forename: Ren-yong
authors.initials: RY
authors.lastname: Lin
authors.forename: Zu-heng
authors.initials: ZH
authors.lastname: Cheng
authors.forename: Jian-bin
authors.initials: JB
authors.lastname: Ding
authors.forename: Mi-la
authors.initials: ML
authors.lastname: Jia
authors.forename: Hao
authors.initials: H
authors.lastname: Wen
authors.forename: Gui-zhen
authors.initials: GZ
authors.lastname: Wu
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Lu
mesh_terms: D044466:Asian People / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics; D002681:China / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D054643:INDEL Mutation; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D044382:Population Groups
chemical_list: D007703:Peptidyl-Dipeptidase A