title: Methylprednisolone in acute spinal cord injuries.
abstract: BACKGROUND
  Methylprednisolone is the only neuroprotective therapy advocated in acute non-penetrating spinal cord injury. Trials indicate improved neurological outcome following early administration of a high dose regime. The National Spinal Injuries Unit (NSIU) has promoted this regime by a simple laminated poster sent to all Irish A&E departments.
  
  
  OBJECTIVE
  To assess the use of methylprednisolone in patients with spinal cord injuries.
  
  
  METHODS
  A retrospective audit of patient data for all patients admitted with traumatic neurological impairment over a 12-month period.
  
  
  RESULTS
  One hundred ninety-six patients were admitted during the study period, 28 (14%) received intravenous methylprednisolone of which six had clear records documenting compliance. One patient received both dexamethasone and methylprednisolone in high doses and three had incorrect bolus dosages administered. Six patients received methylprednisolone infusion longer than the protocol, while five patients were given infusions shorter than recommended. Three patients were admitted to the unit that could have received the steroid regime at the point of transfer.
  
  
  CONCLUSIONS
  There was poor documentation of prescription orders and timing of administration. Only six patients had clear documentation allowing confirmation of adherence to the protocol of the National Acute Spinal Cord Injury Study (NASCIS) III trial.
authors.affiliation: National Spinal Injuries Unit, Department of Orthopaedic Surgery, Mater Misericordiae Hospital, Dublin, Ireland. paoconn@indigo.ie
authors.forename: P A
authors.initials: PA
authors.lastname: O'Connor
authors.forename: O
authors.initials: O
authors.lastname: McCormack
authors.forename: C
authors.initials: C
authors.lastname: Gavin
authors.forename: R
authors.initials: R
authors.lastname: Dungan
authors.forename: C
authors.initials: C
authors.lastname: Kirke
authors.forename: D
authors.initials: D
authors.lastname: McCormack
authors.forename: J
authors.initials: J
authors.lastname: O'Byrne
authors.forename: M
authors.initials: M
authors.lastname: Stephens
authors.forename: F
authors.initials: F
authors.lastname: McManus
authors.forename: M
authors.initials: M
authors.lastname: Walsh
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D013119:Spinal Cord Injuries / Q000188:drug therapy*
chemical_list: D018696:Neuroprotective Agents; D008775:Methylprednisolone