title: Influence of GnRH administration on timing of the LH surge and ovulation in dwarf goats.
abstract: This study was conducted to determine whether or not exogenous gonadotropin releasing hormone (GnRH) alters the timing or improves the synchrony of estrus, the LH surge, and ovulation following estrous synchronization in dwarf goats, and to assess the effects of season on these parameters. In January and June, estrus was synchronized in 12 Pygmy and Nigerian Dwarf goats with a 10-day progestagen sponge, 125 microg cloprostenol i.m. 48 h before sponge removal, and 300 IU equine chorionic gonadotrophin (eCG) i.m. at sponge removal. Six of the 12 goats were given 50 microg GnRH i.m. 24h after sponge removal. Onset of estrus was monitored using two males. Samples for plasma LH were collected at 2 h intervals beginning 22 h after sponge removal and ending at 48 h in January and at 58 h in June. Time of ovulation time was confirmed by laparoscopy at 36, 50, 60, and 74 h in January and at 50, 60, and 74 h in June. Administration of GnRH had no significant effect on the onset of estrus; however, it reduced the interval from sponge removal to the LH surge and improved the synchrony of the LH surge (P<0.05). Treatment with GnRH also reduced the interval from sponge removal to ovulation and improved the synchrony of ovulation (P<0.05). Season had a significant effect on the timing and the synchrony of estrus with and without GnRH treatment (P<0.05). A seasonal shift was also observed in the timing of the LH surge in the absence of GnRH treatment (P<0.05). Further research is required to determine the optimum time for GnRH administration and the minimum effective dose in dwarf goats.
authors.affiliation: Department of Animal Science, McGill University, Macdonald Campus, 21,111 Lakeshore, Ste. Anne de Bellevue, Que., H9X 3V9 Canada.
authors.forename: Janice T
authors.initials: JT
authors.lastname: Pierson
authors.forename: Hernan
authors.initials: H
authors.lastname: Baldassarre
authors.forename: Carol L
authors.initials: CL
authors.lastname: Keefer
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Downey
mesh_terms: D000282:Administration, Intravaginal; D000818:Animals; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D003008:Cloprostenol / Q000008:administration & dosage; D004972:Estrus Detection; D004973:Estrus Synchronization; D005260:Female; D006041:Goats / Q000502:physiology*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006736:Horses; D007700:Kinetics; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage; D010060:Ovulation / Q000187:drug effects*; D012621:Seasons; D013997:Time Factors
chemical_list: D006063:Chorionic Gonadotropin; D007987:Gonadotropin-Releasing Hormone; D003008:Cloprostenol; D007986:Luteinizing Hormone; D017258:Medroxyprogesterone Acetate