The role of natural killer T cells and other T cell subsets against infection by the pre-erythrocytic stages of malaria parasites.
T cells are critical mediators of immunity to the pre-erythrocytic stages of malaria parasites. In this review, we survey the role of the various T cell subsets in combating the pre-erythrocytic stages; in particular, the role of NK T cells. Moreover, we show how studies using malaria models have revealed a unique behavior of NK T cells, namely the bridging of innate and adaptive immunity.
Schmieg
John
J
Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA.
Gonzalez-Aseguinolaza
Gloria
G
Tsuji
Moriya
M
D000818:Animals; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008099:Liver / Q000469:parasitology; D008288:Malaria / Q000276:immunology* / Q000469:parasitology*; D017780:Malaria Vaccines / Q000276:immunology; D010961:Plasmodium / Q000254:growth & development* / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D017780:Malaria Vaccines