[Mathematical simulation of induction of long-term depression in cerebellar Purkinje cells].
Mechanisms of associative and homosynaptic long-term depression (LTD) in cerebellar Purkinje cells are discussed. The possibility of LTD induction related to a decrease in efficacy of AMPA receptors through either their dephosphorylation or phosphorylation is investigated by mathematical simulation.
Murzina
G B
GB
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow. gbmurzina@mail.ru
D015220:Calcium Channels / Q000378:metabolism; D002531:Cerebellum / Q000473:pathology*; D006801:Humans; D008962:Models, Theoretical; D009569:Nitric Oxide / Q000378:metabolism; D010766:Phosphorylation; D011689:Purkinje Cells / Q000473:pathology*; D018091:Receptors, AMPA / Q000378:metabolism; D018079:Receptors, GABA / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
D015220:Calcium Channels; D018091:Receptors, AMPA; D018079:Receptors, GABA; D016194:Receptors, N-Methyl-D-Aspartate; D009569:Nitric Oxide