Lysosomal cysteine proteases regulate antigen presentation.
Antigen presentation by both classical MHC class II molecules and the non-classical MHC class I-like molecule CD1D requires their entry into the endosomal/lysosomal compartment. Lysosomal cysteine proteases constitute an important subset of the enzymes that are present in this compartment and, here, we discuss the role of these proteases in regulating antigen presentation by both MHC class II and CD1D molecules.
Honey
Karen
K
Howard Hughes Medical Institute and Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195, USA. khoney@u.washington.edu
Rudensky
Alexander Y
AY
D000818:Animals; D017951:Antigen Presentation; D018949:Antigens, CD1 / Q000276:immunology; D055610:Antigens, CD1d; D056668:Cathepsin L; D002403:Cathepsins / Q000276:immunology; D003546:Cysteine Endopeptidases / Q000276:immunology*; D004789:Enzyme Activation; D005802:Genes, MHC Class II / Q000276:immunology; D006801:Humans; D008221:Lymphoid Tissue / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology*; D051379:Mice
D018949:Antigens, CD1; D055610:Antigens, CD1d; C526877:CD1D protein, human; D002403:Cathepsins; D003546:Cysteine Endopeptidases; C534281:CTSL protein, human; D056668:Cathepsin L; C534278:Ctsl protein, mouse; C028217:cathepsin S