Diffuse large B-cell lymphoma: insights gained from gene expression profiling.
Analysis of global gene expression with DNA microarrays has great potential to improve the understanding of tumorigenesis advance tumor diagnosis and classification, and affect cancer treatment. Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. However, we now realize that the disease is extremely heterogeneous. This review summarizes the progress in understanding DLBCL that has been made as a result of the application of gene expression profiling.
Lossos
Izidore S
IS
Department of Hematology and Oncology, University of Miami, Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA.
Levy
Ronald
R
D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D015398:Signal Transduction / Q000235:genetics