Effect of folic acid supplementation on plasma zinc concentrations of young women.
OBJECTIVE
Women of reproductive age are advised to consume supplements or fortified foods containing at least 400 microg/d folic acid for the prevention of neural tubes defects. Concerns exist about the adverse effects of folic acid on zinc status.


METHODS
Seventy-eight women (18 to 49 y) were assigned for 12-wk to receive either a placebo or a 400 microg/d folic acid supplement.


RESULTS
At 12-wk mean (95% CI) red cell folate increased by 431 (350-511) nmol/L in the supplemented group relative to placebo (P < 0.001) but there was no change in plasma zinc in either group (P = 0.213).


CONCLUSIONS
Folic acid supplementation does not reduce plasma zinc concentrations in women of childbearing age.
Green
Timothy J
TJ
Department of Human Nutrition, University of Otago, PO Box 56, Dunedin, New Zealand. tim.green@stonebow.otago.ac.nz
Skeaff
C Murray
CM
Whiting
Susan J
SJ
Gibson
Rosalind S
RS
D000293:Adolescent; D000328:Adult; D019587:Dietary Supplements; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D008875:Middle Aged; D010919:Placebos; D015032:Zinc / Q000097:blood*
D010919:Placebos; D005492:Folic Acid; D015032:Zinc