[Roles of CD43, CD20 and local IgE in the pathogenesis of nasal polyps].
OBJECTIVE
To estimate the roles of CD43, CD20 and total IgE in the pathogenesis of nasal polyps.


METHODS
Twenty-six cases of nasal polyps and 20 cases of mucosa of middle turbinates were used in present study.


RESULTS
The number of CD43+ cells, CD20+ cells and plasma cells in nasal polyps were significantly more than that in middle turbinates (P < 0.01). The positive rate of local IgE+ cells in nasal polyps was significantly higher than in middle turbinate (P < 0.01).


CONCLUSIONS
There were active cellular immunity and humoral immunity in nasal polyps. Local allergy may play a role in the pathogenesis of nasal polyps.
Wang
X
X
Beijing Institute of Otorhinolaryngology, Beijing 100005, China. wangxiangdong88@sina.com
Guo
J
J
Zhang
H
H
Tao
G
G
Han
D
D
Zhu
X
X
Fan
E
E
Li
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD; D018951:Antigens, CD20 / Q000096:biosynthesis / Q000502:physiology*; D002648:Child; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000276:immunology; D051917:Leukosialin; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000209:etiology* / Q000276:immunology; D012795:Sialoglycoproteins / Q000096:biosynthesis / Q000502:physiology*
D015703:Antigens, CD; D018951:Antigens, CD20; D051917:Leukosialin; C465014:SPN protein, human; D012795:Sialoglycoproteins; D007073:Immunoglobulin E