The administration of the GnRH antagonist, cetrorelix, to ooctye donors simplifies oocyte donation.
BACKGROUND
We report our experience on the efficacy of a new regimen of the GnRH antagonist, cetrorelix, and recombinant FSH, Gonal-F, for controlled ovarian stimulation in a donor oocyte programme.


RESULTS
Six oocyte donors were commenced on Gonal-F (150 IU) and two on Gonal-F 225 IU daily on day 4 together with cetrorelix 0.25 mg daily on day 8 until the day of administration of hCG. Six premenopausal recipients were down-regulated with intranasal Nafarelin 400 micro g twice daily; two women with premature menopause did not require down-regulation for synchronization between donor and recipient cycles. The median (range) of oocytes retrieved and the median (range) fertilization rates were 7 (3-13) and 50% (0-71%) respectively. With the exception of a recipient who had failed fertilization, seven recipients had two embryos transferred. The median (range) number of days of ovarian stimulation, cetrorelix administration and number of Gonal-F ampoules administered for ovarian stimulation were 9 (7-12) days, 5 (3-8) and 18 (14-24) respectively. The clinical pregnancy rate per cycle was 50% (4/8) and one of the latter women miscarried at eight weeks gestation. Three women (37.3%) had full term deliveries.


CONCLUSIONS
This preliminary study has shown that using a combination of cetrorelix and Gonal-F resulted in a high pregnancy rate, reduced the duration of treatment for the donor and simplified oocyte donation.
Thong
K J
KJ
Assisted Conception Programme, Edinburgh Fertility and Reproductive Endocrine Centre, Edinburgh Royal Infirmary, Little France, 51 Little France Crescent, Scotland. joothong@hotmail.com
Yong
P Y
PY
Menezes
Q
Q
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D043373:Follicle Stimulating Hormone, Human / Q000008:administration & dosage; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors*; D006801:Humans; D008875:Middle Aged; D017274:Nafarelin / Q000008:administration & dosage; D018587:Oocyte Donation / Q000379:methods*; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D020858:Tissue and Organ Harvesting / Q000379:methods
D006063:Chorionic Gonadotropin; D043373:Follicle Stimulating Hormone, Human; D017274:Nafarelin; D007987:Gonadotropin-Releasing Hormone; C062876:cetrorelix