Preparation and antimicrobial behaviour of gemini fluorosurfactants.
The introduction of perfluorinated chains in the molecular structure of quaternary ammonium gemini surfactants have led to particularly active antimicrobial agents evaluated in this work. Connectors and spacers were studied in relation with antimicrobial activity in order to determine which molecular parameters are "critical" for biological activity.
Massi
Lionel
L
Chimie des matériaux organiques et métalliques (CMOM), Université de Nice Sophia-Antipolis, faculté des sciences, parc valrose, 28 avenue de valrose, 06108 Nice cedex 2, France.
Guittard
Frédéric
F
Levy
Richard
R
Duccini
Yves
Y
Géribaldi
Serge
S
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D006845:Hydrocarbons, Fluorinated; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents