Hypertension due to blockade of adenosine receptors.
Chronic treatment of rats with 90 microg/kg/day DPSPX (1,3-dipropyl-8-sulphophenylxanthine) during seven days leads to a hypertensive state which is characterized by marked morphological changes of the blood vessel walls as well as by important functional alterations. While the angiotensin-converting enzyme (ACE) inhibitor captopril and the antagonist of angiotensin II AT 1 receptors losartan prevent the development of both hypertension and morphological changes, the selective beta1-adrenoceptor antagonist atenolol could prevent only the increase in blood pressure. It is concluded that at least two factors are involved in the development of the hypertensive state.
Guimarães
Serafim
S
Institute of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Alameda Hernani Monteiro 4200-319, Porto, Portugal. sguimara@med.up.pt
Morato
Manuela
M
Sousa
Teresa
T
Albino-Teixeira
António
A
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006973:Hypertension / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D009638:Norepinephrine / Q000378:metabolism; D058915:Purinergic P1 Receptor Antagonists; D051381:Rats; D017208:Rats, Wistar; D014970:Xanthines
D000959:Antihypertensive Agents; D058915:Purinergic P1 Receptor Antagonists; D014970:Xanthines; C053896:1,3-dipropyl-8-(4-sulfophenyl)xanthine; D009638:Norepinephrine