title: [A five-year-old girl with epilepsy showing forced normalization due to zonisamide].
abstract: A case of forced normalization in childhood is presented. When zonisamide was administered to a five-year-old girl with intractable epilepsy, disappearance of seizures was accompanied by severe psychotic episodes such as communication disturbance, personal relationship failure, and stereotyped behavior, which continued after the withdrawal of zonisamide. These symptoms gradually improved by administration of fluvoxamine, however epileptic attacks reappeared. Although most patients with forced normalization are adult and teenager, attention should be paid to this phenomenon as adverse psychotic effects of zonisamide even in young children. Fluvoxamine may be effective for the symptoms.
authors.affiliation: Department of Pediatrics, Tohoku University School of Medicine, Sendai. mhirose@ped.med.tohoku.ac.jp
authors.forename: Mieko
authors.initials: M
authors.lastname: Hirose
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yokoyama
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Haginoya
authors.forename: Kazuie
authors.initials: K
authors.lastname: Iinuma
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D002653:Child Behavior Disorders / Q000139:chemically induced* / Q000188:drug therapy; D002675:Child, Preschool; D003147:Communication Disorders / Q000139:chemically induced; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D016666:Fluvoxamine / Q000627:therapeutic use; D006801:Humans; D007555:Isoxazoles / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000188:drug therapy; D000078305:Zonisamide
chemical_list: D000927:Anticonvulsants; D007555:Isoxazoles; D000078305:Zonisamide; D016666:Fluvoxamine