Regulatory T cells in the control of transplantation tolerance and autoimmunity.
A role for immunoregulatory T cells in the maintenance of self-tolerance and in transplantation tolerance has long been suggested, but the identification of such cells has not been achieved until recently. With the characterisation of spontaneously occurring CD4+CD25+ and NK1.1+ T subpopulations of T cells as regulatory cells in rodents and in humans, together with several in vitro generated regulatory T-cell populations, it seems possible that 'customised' regulatory cells possessing antidonor specificity may become therapeutic tools in clinical transplantation tolerance.
Jiang
Shuiping
S
Department of Immunology, Faculty of Medicine, Imperial College, Hammersmith Hospital, Du Cane Road, London, UK.
Lechler
Robert I
RI
D000818:Animals; D000918:Antibody Specificity; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000502:physiology; D015551:Autoimmunity; D018106:CD28 Antigens / Q000096:biosynthesis; D017252:CD3 Complex / Q000096:biosynthesis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D060908:CTLA-4 Antigen; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism; D007694:Killer Cells, Natural; D051381:Rats; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism; D023001:Transplantation Tolerance
D015703:Antigens, CD; D000943:Antigens, Differentiation; D018106:CD28 Antigens; D017252:CD3 Complex; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D015375:Receptors, Interleukin-2; D016212:Transforming Growth Factor beta; D016753:Interleukin-10