title: Transgenics at breaking-point.
abstract: In this issue of Cancer Cell, Forster et al. (2003) have generated mice that recapitulate both the mechanism (sporadic somatic translocation) and the consequences (expression of two translocation fusion genes) leading to an accurate leukemia model.
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.
authors.forename: Haydn
authors.initials: H
authors.lastname: Prosser
authors.forename: Allan
authors.initials: A
authors.lastname: Bradley
mesh_terms: D000818:Animals; D018076:DNA, Complementary / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D019426:Integrases; D007938:Leukemia / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D008957:Models, Genetic; D014178:Translocation, Genetic; D014764:Viral Proteins
chemical_list: D018076:DNA, Complementary; D014764:Viral Proteins; C045073:Cre recombinase; D019426:Integrases