title: The Genetic Sonogram Scoring Index.
abstract: This article describes the individual sonographic markers used in the Genetic Sonogram Scoring Index. The importance of the clustering of markers forms the basis of the scoring index, such that individual markers are assigned point values based on their sensitivity and specificity in the detection of Down syndrome. The points acquired by each fetus are tabulated into a final "score." The performance of the scoring index in the detection of aneuploidy is presented. The clinical application of the scoring index for the detection of chromosomally abnormal fetuses in patients both at high- and low-risk for aneuploidy is discussed.
authors.affiliation: Department of Obstetrics and Gynecology, Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. bbsono@aol.com
authors.forename: Bryann
authors.initials: B
authors.lastname: Bromley
authors.forename: Beryl R
authors.initials: BR
authors.lastname: Benacerraf
mesh_terms: D000328:Adult; D000782:Aneuploidy; D015415:Biomarkers; D004314:Down Syndrome / Q000000981:diagnostic imaging; D005260:Female; D005333:Fetus / Q000002:abnormalities / Q000502:physiology; D006801:Humans; D008423:Maternal Age; D011237:Predictive Value of Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000502:physiology; D018566:Pregnancy, High-Risk; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal / Q000379:methods*
chemical_list: D015415:Biomarkers