[Rat behavior in the "open field" next day after haloperidol injection: dependence on experimental conditions].
Wistar rats were injected with haloperidol (3.5 mg/kg) that resulted in a high level of cataplexy. Next day after haloperidol injection rat behavior was studied in the open field. The animals were divided in two groups. The first group of animals was tested in the daylight without additional illumination of the open-field chamber. The second group was tested in a darkened room with additional intense illumination of the open-field center with a 60W bulb. The testing time was 240 s. The high level of the open-field locomotor activity in the first group was attributed to anxiety. The low level of locomotor activity in the second group was qualified as depressive state.
Orlova
N V
NV
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Folomkina
A A
AA
Bazian
A S
AS
D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D001522:Behavior, Animal / Q000187:drug effects*; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects*; D007267:Injections; D008027:Light; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D018492:Dopamine Antagonists; D006220:Haloperidol