Effects of the vasoactive intestinal peptide on stress-induced mucosal ulcers and modulation of methylation of histamine in gastric tissue of the rats.
Vasoactive intestinal peptide (VIP) prevents stress-induced gastric ulcers, inhibits mast cell degranulation and protects gastric tissue from lipid peroxidation. Histamine has an important role in the development of gastric ulcers and mast cell derived histamine might be essential in this process.
Tunçel
Nese
N
Department of Physiology, Faculty of Medicine, University of Osmangazi, 26040 Eskisehir, Turkey.
Tunçel
Muzaffer
M
Aboul-Enein
Hassan Y
HY
D000818:Animals; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006632:Histamine / Q000378:metabolism*; D008297:Male; D008745:Methylation / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000378:metabolism; D013312:Stress, Physiological / Q000188:drug therapy* / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology / Q000627:therapeutic use*
D014660:Vasoactive Intestinal Peptide; D006632:Histamine