Improving needle-point sharpness in prefillable syringes.
Improvement of needle-point sharpness and improved injection comfort for patients remain active areas of research. This article reports on a five-bevel needle for subcutaneous administration with a prefillable syringe, and the results of a clinical trial to verify and validate the bench measure of sharpness.
Vedrine
L
L
BD Pharmaceutical Systems, Le Pont de Claix, France.
Prais
W
W
Laurent
P E
PE
Raynal-Olive
C
C
Fantino
M
M
D000293:Adolescent; D000328:Adult; D018592:Cross-Over Studies; D004867:Equipment Design / Q000379:methods*; D019544:Equipment Failure Analysis / Q000379:methods*; D005260:Female; D006801:Humans; D007267:Injections / Q000295:instrumentation*; D008297:Male; D008422:Materials Testing / Q000379:methods; D008875:Middle Aged; D009339:Needles; D010465:Perception; D011786:Quality Control; D016037:Single-Blind Method; D012879:Skin Physiological Phenomena; D012986:Software Validation; D013314:Stress, Mechanical; D013499:Surface Properties; D013594:Syringes