Significance of endothelial cell survival programs for renal transplantation.
Initial and longer term kidney transplant function is determined in part by the renal allograft microcirculation because it provides a thromboresistant surface, regulates cellular infiltration, and elaborates paracrine and autocrine growth and survival factors. Loss of endothelial-derived signaling mediators accelerates vascular injury and endothelial cell (EC) death. EC apoptosis is implicated in accelerated allograft vasculopathy and premature loss of organ function. Renal allograft EC injury and replacement by recipient-derived repair mechanisms has long been proposed to influence allograft acceptance and function. Repair of cellular injury in allografts is linked with cell-survival mechanisms, but few precise indicators exist to predict recovery and repair in organ transplants. The significance of the growth phenotype of the microvascular endothelium for acute and longer term renal allograft survival is presented.
Hall
Anne V
AV
Division of Nephrology and Multi-Organ Transplant Program, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada.
Jevnikar
Anthony M
AM
D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; D002352:Carrier Proteins / Q000502:physiology; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases / Q000502:physiology; D015687:Cell Hypoxia; D002470:Cell Survival; D042783:Endothelial Cells / Q000502:physiology*; D004730:Endothelium, Vascular / Q000473:pathology*; D006084:Graft Rejection / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007511:Ischemia / Q000473:pathology; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D016030:Kidney Transplantation; D008833:Microcirculation; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D012079:Renal Circulation; D013234:Stem Cells / Q000166:cytology; D020858:Tissue and Organ Harvesting / Q000379:methods
D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; C506386:CFLAR protein, human; D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; C505530:CASP8 protein, human; C506433:CASP9 protein, human; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases