title: Complexity and genetic diversity of Plasmodium falciparum infections in young children living in urban areas of Central and West Africa.
abstract: A site-based characterization of Plasmodium falciparum infections in children living in two malaria hyperendemic urban areas from West and Central Africa was undertaken. A total of 58 and 46 children with either asymptomatic infections or uncomplicated (symptomatic) malaria were recruited in Gabon and Benin, respectively. Parasite density, hematological factors, the genetic diversity of P. falciparum merozoite surface protein 2 (msp2) and the complexity of infections (mean number of P. falciparum genotypes per infected child) were used for this characterization. Gabonese children with uncomplicated malaria presented a higher mean axillary temperature (39.2 vs 38.6, P=0.004) and a higher geometric mean parasite density (30,538 vs 18,921, P<0.001) associated with a significantly lower hemoglobin level ( P<0.01). A higher degree of msp2 polymorphism and the complexity of P. falciparum infections were also observed in children from Gabon ( P<0.05). With a similar level of malaria transmission in both urban sites, these results suggest an impact of malaria control interventions on the dynamics of concurrent P. falciparum infections.
authors.affiliation: Centre Régional pour le Développement et la Santé (CREDESA/SSP), Cotonou, Benin.
authors.forename: Saadou
authors.initials: S
authors.lastname: Issifou
authors.forename: Christophe
authors.initials: C
authors.lastname: Rogier
authors.forename: Marius
authors.initials: M
authors.lastname: Adjagba-Olakpo
authors.forename: Nicodème
authors.initials: N
authors.lastname: Chabi-Worou
authors.forename: Francine
authors.initials: F
authors.lastname: Ntoumi
mesh_terms: D000483:Alleles; D000818:Animals; D000953:Antigens, Protozoan / Q000235:genetics*; D001541:Benin / Q000453:epidemiology; D002675:Child, Preschool; D019353:Endemic Diseases; D005260:Female; D005681:Gabon / Q000453:epidemiology; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000469:parasitology*; D008297:Male; D010963:Plasmodium falciparum / Q000235:genetics*; D011110:Polymorphism, Genetic; D015800:Protozoan Proteins / Q000235:genetics*
chemical_list: D000953:Antigens, Protozoan; D015800:Protozoan Proteins; C065974:merozoite surface protein 2, Plasmodium