Prenatal diagnosis of congenital leukemia in a fetus at 25 weeks' gestation with Down syndrome: case report and review of the literature.
Leukemia in a hydropic fetus with hepatosplenomegaly and Down syndrome was diagnosed at 25 weeks' gestation. Spontaneous demise occurred 10 days after the cordocentesis. A review of the literature of the seven cases described antenatally and 10 cases described in the immediate neonatal period or on examination of the stillborn baby is presented.
Robertson
M
M
Department of Obstetrics and Gynecology, University of Stellenbosch, South Africa. mroberts@gerga.sun.ac.za
De Jong
G
G
Mansvelt
E
E
D000328:Adult; D017218:Cordocentesis; D003937:Diagnosis, Differential; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D005313:Fetal Death; D005865:Gestational Age; D006529:Hepatomegaly / Q000150:complications; D006801:Humans; D015160:Hydrops Fetalis / Q000150:complications; D007938:Leukemia / Q000151:congenital / Q000000981:diagnostic imaging*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D016216:Ultrasonography, Prenatal / Q000379:methods*