[Renin-angiotensin system and heart failure].
The local renin-angiotensin system in cardiac tissue has been demonstrated to be involved in the pathophysiology of cardiac hypertrophy and heart failure. Angiotensin II type 1(AT1) receptor stimulation leads to vasoconstriction, cell growth, oxidation, aldosterone release, and fibrosis. Recent evidence suggests that angiotensin II type 2(AT2) receptor exerts cardioprotective effects by counteracting against AT1 receptor. However, the role of AT2 receptor signaling in cardiac hypertrophy and fibrosis still remain controversial. This review focused on the accumulating evidence for the cardiac renin-angiotensin system in heart failure.
Suzuki
Jun
J
Second Department of Internal Medicine, First Department of Medical Biochemistry, Ehime University School of Medicine.
Horiuchi
Masatsugu
M
D000818:Animals; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D020257:Ventricular Remodeling
D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin