title: Effects of moderate to severe osteoarthritis on canine thyroid function.
abstract: Several nonthyroidal illnesses in euthyroid dogs can affect the results of thyroid function testing, making interpretation of the results more difficult with an increased risk of overdiagnosing hypothyroidism. The purpose of this study was to evaluate the effect of chronic, moderate to severe, osteoarthritis on canine thyroid function. Ninety-six, healthy, client-owned dogs, 65 of which were suffering from moderate to severe osteoarthritis and 31 euthyroid dogs without any physical evidence of osteoarthritis, were used in this study. Blood samples were collected to evaluate serum basal total thyroxine (TT4), free thyroxine (FT4), and thyrotropin (TSHc) concentrations. Basal serum TT4 concentration was not affected by osteoarthritis in dogs. Mild, but statistically significant, differences were noticed in FT4 and TSHc concentrations among the 2 groups. However, this had limited clinical relevance, since virtually all values were within their reference range, and no dogs would have been misdiagnosed as hypothyroid. Therefore, based on the results of our study, osteoarthritis does not need to be considered a factor influencing thyroid function evaluation in dogs.
authors.affiliation: Département de sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, C.P. 5000, Saint-Hyacinthe, Québec J2S 7C6.
authors.forename: Manon
authors.initials: M
authors.lastname: Paradis
authors.forename: Frédéric
authors.initials: F
authors.lastname: Sauvé
authors.forename: Julie
authors.initials: J
authors.lastname: Charest
authors.forename: Kent R
authors.initials: KR
authors.lastname: Refsal
authors.forename: Maxim
authors.initials: M
authors.lastname: Moreau
authors.forename: Jacques
authors.initials: J
authors.lastname: Dupuis
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood; D016022:Case-Control Studies; D002908:Chronic Disease; D004283:Dog Diseases / Q000097:blood / Q000503:physiopathology*; D004285:Dogs; D005067:Euthyroid Sick Syndromes / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D005260:Female; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D008297:Male; D010003:Osteoarthritis / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D013954:Thyroglobulin / Q000276:immunology; D013960:Thyroid Function Tests / Q000662:veterinary; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; D013972:Thyrotropin; D013954:Thyroglobulin; D013974:Thyroxine