[Enzyme histochemistry study of non-focused ultrasound irradiating the cochlea in guinea pigs].
OBJECTIVE
To study the enzyme histochemistry changes of non-focused ultrasound (NFU) irradiating the cochlea in guinea pigs.


METHODS
After 30 minutes or 8 hours of 2.5 MHz, 8 MHz NFU irradiating the cochlea in guinea pigs (70 ears) for 6 hours, the SDH activity of the hair cells of the cochlea was observed.


RESULTS
The non-focused ultrasound (2.5 MHz or 8 MHz) irradiation for 6 hours has lad to enervation of the activity of SDH in hair cells, especially in outer hair cells, in the 0.87 +/- 0.20 mm areas of the second turn or in the 0.80 +/- 0.20 mm areas of the first turn, respectively. The activity of SDH can be part restorable in the 8 hours groups.


CONCLUSIONS
NFU (2.5 MHz, 8 MHz) irradiating the cochlea for 6 hours can cause pathological changes in the hair cells of in different areas of cochlear. Moreover, the pathological changes could be restorable or part restorable in some amounts of NFU irradiation. The results suggest that the cochlear hair cell of the different area might be related to ultrasonic perception.
Wang
Fusen
F
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430022, China. Wafus@163.com
Wang
Jibao
J
D000818:Animals; D003051:Cochlea / Q000166:cytology*; D005260:Female; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000201:enzymology* / Q000528:radiation effects; D008297:Male; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D014465:Ultrasonics
D013385:Succinate Dehydrogenase