title: [Therapy resistant major depression: improvement of symptomatology after combining antidepressants with Tianeptine (Stablon)].
abstract: OBJECTIVE
  In common, depressive disorders are treated with various antidepressants, the number of which is enormously increasing. Nevertheless, in some cases therapy resistance is observed. In these cases, neuroleptics are used as an alternative. Recently, Tianeptin (Stablon) has also been used for the treatment of depressive disorders.
  
  
  METHODS
  We report a 32-year old "therapy resistant" depressive female. Monotherapy with antidepressants and Tianeptin (Stablon) was ineffective.
  
  
  RESULTS
  Finally, a combination of antidepressants and Tianeptin (Stablon) was effective and lowered the HAMD-Score significantly.
  
  
  CONCLUSIONS
  A combination of antidepressants and Tianeptin (Stablon) seems to be an effective new Option for the treatment of "therapy resistant" major depressions.
authors.affiliation: Univ.-Klinik für Psychiatrie, Abt. für Kinder- und Jugendpsychiatrie, Innsbruck, Austria.
authors.forename: Helmut
authors.initials: H
authors.lastname: Niederhofer
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000008:administration & dosage; D000928:Antidepressive Agents / Q000008:administration & dosage*; D015283:Citalopram / Q000008:administration & dosage; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D013841:Thiazepines / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D013841:Thiazepines; D015283:Citalopram; C050504:tianeptine; D000639:Amitriptyline