Simple diastereoselectivity on addition of alpha-haloalkyl Grignard reagents to benzaldehyde.
The addition of alpha-haloalkyl Grignard reagents to benzaldehyde occurs with simple diastereoselectivity substantially higher than that of the corresponding lithium reagents. Reaction in the presence of dimethyl-aluminum chloride suppresses subsequent Oppenauer oxidation of the resulting Mg-alkoxides by excess benzaldehyde.
Schulze
Volker
V
Fachbereich Chemie der Philipps-Universität Marburg, Hans Meerwein Str., Germany.
Nell
Peter G
PG
Burton
Andrew
A
Hoffmann
Reinhard W
RW