title: Unwinding of DNA polymerases by the antitumor drug, cis-diamminedichloroplatinum(II).
abstract: The helix-turn-helix motifs of the DNA binding domains of human polymerase-alpha and polymerase-kappa are dramatically perturbed upon binding to cisplatin with concomitant release of zinc.
authors.affiliation: Department of Chemistry, School of Biomedical Sciences, Kent State University, Kent, OH 44242, USA.
authors.forename: Erika
authors.initials: E
authors.lastname: Volckova
authors.forename: Ferenc
authors.initials: F
authors.lastname: Evanics
authors.forename: Wei W
authors.initials: WW
authors.lastname: Yang
authors.forename: Rathindra N
authors.initials: RN
authors.lastname: Bose
mesh_terms: D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites; D002942:Circular Dichroism; D002945:Cisplatin / Q000378:metabolism / Q000494:pharmacology*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D017434:Protein Structure, Tertiary / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D004268:DNA-Binding Proteins; D004259:DNA-Directed DNA Polymerase; D002945:Cisplatin