[Study on the preparation of venenum bufonis beta-cyclodextrin inclusion complexes].
OBJECTIVE
To study the preparation of Venenum Bufonis beta-cyclodextrin inclusion complexes.


METHODS
An optimal condition was established by the uniform design. Under the optimal conditions the Venenum Bufonis beta-cyclodextrin inclusion complexes were prepared with 5 different methods.


RESULTS
The ball grinding method was superior to other four methods. The bufadienolide inclusion rate of Venenum Bufonis beta-cyclodextrin prepared with ball grinding method was 85.42%.


CONCLUSIONS
Ball grinding method is the best method for the preparation of Venenum Bufonis beta-cyclodextrin inclusion complexes.
Guo
Tao
T
Shenyang Military General Hospital, Shenyang 110016, Liaoning, China.
Song
Hong-tao
HT
Zhao
Ming-hong
MH
Zhang
Ru-hua
RH
Li
Xian
X
D000664:Amphibian Venoms / Q000008:administration & dosage* / Q000737:chemistry; D000818:Animals; D002018:Bufanolides; D002023:Bufo bufo; D002770:Cholenes / Q000032:analysis; D003505:Cyclodextrins; D004337:Drug Carriers; D004355:Drug Stability; D008419:Materia Medica / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D047392:beta-Cyclodextrins
D000664:Amphibian Venoms; D002018:Bufanolides; D002770:Cholenes; D003505:Cyclodextrins; D004337:Drug Carriers; D008419:Materia Medica; D047392:beta-Cyclodextrins; C087925:bufadienolide; C031215:betadex