title: [The association of HLA-DRB1 allele polymorphism with the genetic susceptibility to liver cirrhosis due to hepatitis B virus].
abstract: OBJECTIVE
  To assess the association of human leucocyte antigen (HLA)-DRB1 allele with the genetic susceptibility to cirrhosis due to hepatitis B virus(HBV).
  
  
  METHODS
  One hundred and six patients with cirrhosis due to HBV in Hubei area were investigated for HLA-DRB1 gene by polymerase chain reaction-sequence specific primers technique. The results were compared with those from 108 normal healthy people.
  
  
  RESULTS
  The frequency of HLA-DRB1*1201/1202 allele was 20.28% in patient group, which was significantly higher than the frequency (6.01%) in control group, the relative risk (RR) being 4.9878 (P<0.01). The frequency of HLA-DRB1*1501/1502 allele was decreased in patient group (patient 6.6%, control 16.67%, RR=0.3043, P<0.05), while the frequencies of other HLA-DRB1 alleles were not significantly different(P>0.05).
  
  
  CONCLUSIONS
  HLA-DRB1*1201/1202 allele may be the susceptibility gene in patients with cirrhosis due to HBV in Hubei Han nationality; HLA-DRB1*1501/1502 allele is a resistant gene in patients with cirrhosis.
authors.affiliation: Institute of the Liver Diseases, Tongji Medical College, University of Huazhong Science and Technology, Wuhan, Hubei, 430030 PR China.
authors.forename: Yuan-qiao
authors.initials: YQ
authors.lastname: Cheng
authors.forename: Ju-sheng
authors.initials: JS
authors.lastname: Lin
authors.forename: Li-hong
authors.initials: LH
authors.lastname: Huang
authors.forename: De-ying
authors.initials: DY
authors.lastname: Tian
authors.forename: Ping
authors.initials: P
authors.lastname: Xiong
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006509:Hepatitis B / Q000150:complications / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics / Q000472:pathogenicity*; D019694:Hepatitis B, Chronic / Q000150:complications / Q000235:genetics; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains