title: [Roles of leptin in the development during girls'puberty].
abstract: OBJECTIVE
  To study the roles of leptin in the development during puberty in girls and the its relationship with insulin (INS), growth hormone (GH), estradiol (E(2)) and testosterone (T).
  
  
  METHODS
  One hundred and fifty girls with simple obese aged 7 to 17 years, and 150 normal healthy girls and 150 girls with malnutrition matched for age (+/- 3 months) and height (+/- 2 cm) were selected. Serum levels of leptin, INS, GH, E(2) and T were measured for them.
  
  
  RESULTS
  Their serum level of leptin positively correlated with body mass index (BMI) and age. Serum level of leptin in girls increased steadily from Tanner stage B(1) to stage B(5). At Tanner stage B(2), serum level of leptin in the normal groups (7.72 microg/L) was not significantly different from that in those with malnutrition (7.36 microg/L), but significantly lower than that in the obese groups (12.85 microg/L). At other Tanner stages, there was significant difference in serum level of leptin among obese, normal and malnutrition groups. Serum level of leptin correlated negatively with serum GH and positively with serum INS, but not correlated with E(2) and T.
  
  
  CONCLUSIONS
  Leptin may play a role in triggering development during puberty in girls. Serum level of leptin at Tanner stage B(2) may be the threshold dose to trigger the onset of puberty in girls. Quickly increasing level of leptin at Tanner stage B(5) may inhibit the increase of GH, which ushered the end of puberty in girls.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150001, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Chang-hao
authors.initials: CH
authors.lastname: Sun
authors.forename: Pu
authors.initials: P
authors.lastname: Chen
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.forename: Rui-qin
authors.initials: RQ
authors.lastname: Fan
mesh_terms: D000293:Adolescent; D001827:Body Height / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000097:blood / Q000502:physiology*; D011627:Puberty / Q000502:physiology*; D013739:Testosterone / Q000378:metabolism
chemical_list: D020738:Leptin; D013739:Testosterone; D013006:Growth Hormone