New antimalarial bis-dehydroaporphine alkaloids from Polyalthia debilis.
Four new dimeric aporphinoids named bidebilines A-D (1-4), bis-7,7'-dehydroanonaine (1), 7-dehydroanonaine-7'-dehydro-8'-methoxyanonaine (2), bis-7,7'-dehydro-8,8'-dimethoxyanonaine (3), and bis-7,7'-dehydro-10,10'-dimethoxyanonaine (4), were isolated from the roots of Polyalthia debilis. Their structures were established on the basis of spectral evidence. Compounds 3 and 4 exhibited moderate antimalarial activity with IC(50) values of 5.4 and 4.1 microg/mL, respectively.
Kanokmedhakul
Somdej
S
Department of Chemistry, Faculty of Science, Khon Kaen University, Thailand. somdej@kku.ac.th
Kanokmedhakul
Kwanjai
K
Yodbuddee
Daungrudee
D
Phonkerd
Nutchanat
N
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D031044:Polyalthia / Q000737:chemistry*; D013785:Thailand
D000470:Alkaloids; D000962:Antimalarials