Stereoselective synthesis of tetrasubstituted 2,3-dihydrofurans by one-step cyclization of beta-ketosulfides of benzothiazole and aldehydes in ionic liquids.
A stereoselective synthesis of tetrasubstituted 2,3-dihydrofurans was carried out in n-butylpyridinium tetrafluoroborate ([bpy(+)][BF(4)(-)]) as solvent. The reaction proceeds smoothly in one step starting from simple materials such as aldehydes and beta-ketosulfides of benzothiazole. A comparison between several ionic liquids (ILs) is presented, and the role of the benzothiazolyl moiety is discussed. Workup proved to be very easy and recycling of IL possible.
Calò
Vincenzo
V
Istituto di Chimica dei Composti Organometallici - ICCOM, Department of Chemistry, University of Bari, Via Amendola 173, Italy.
Scordari
Fernando
F
Nacci
Angelo
A
Schingaro
Emanuela
E
D'Accolti
Lucia
L
Monopoli
Antonio
A