title: [A case of idiopathic pulmonary upper lobe fibrosis complicated by invasive pulmonary aspergillosis].
abstract: A 72-year-old man with idiopathic pulmonary upper lobe fibrosis who had been followed for a year developed a high fever and yellow sputum in July 2001. Chest radiography and chest computed tomography (CT) showed a rapidly enlarging cavity with an internal mass and infiltration in the left upper lung field. Pulmonary aspergillosis was diagnosed by examination of bronchoalveolar lavage fluid (BALF). Administration of itraconazole improved his condition. The concentrations of surfactant proteins A (SP-A) and D (SP-D) in serum and in BALF were decreased during the clinical course. It is known that SP-A and SP-D are critical factors for host defense against aspergillus. The lowering of SP-A and SP-D in the serum and BALF seemed to reflect destructive changes of lung structure and impaired innate lung immunity that could to lead invasive pulmonary aspergillosis.
authors.affiliation: First Department of Medicine, Hokkaido University, School of Medicine, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fuke
authors.forename: Tomoko
authors.initials: T
authors.lastname: Betsuyaku
authors.forename: Satoshi
authors.initials: S
authors.lastname: Oizumi
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nasuhara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Saito
authors.forename: Etsuro
authors.initials: E
authors.lastname: Yamaguchi
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nishimura
mesh_terms: D000368:Aged; D001228:Aspergillosis / Q000209:etiology*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D006801:Humans; D007113:Immunity, Innate; D008172:Lung Diseases, Fungal / Q000209:etiology*; D008297:Male; D011658:Pulmonary Fibrosis / Q000150:complications* / Q000276:immunology*; D037662:Pulmonary Surfactant-Associated Protein A / Q000032:analysis* / Q000502:physiology; D037663:Pulmonary Surfactant-Associated Protein D / Q000032:analysis* / Q000502:physiology
chemical_list: D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D