[Study on the compatibility of composite herbal medicines of the lingguizhugan decoction].
OBJECTIVE
To study the compatibility of composite herbal medicines of the Ling Gui Zhu Gan Decoction.


METHODS
Ethanol extract test solutions of the different combinations were prepared according to the orthogonal layout L16(4(5)). Pharmacologic experiments, such as the time of surviving of mice in shortage of oxygen in regular air pressure, the antagonizing effect on arrhythmia induced by chloroform and diuresis were carried out with the solutions. Variance analysis, canonical correlation and stepwise regression analysis were applied to interrelate the amount of each drug and the pharmacologic data.


RESULTS
The results confirmed that Fuling and Guizhi are the basis, while Baizhuand Gancao are the adjuvans, which is conformed to the theory of TCM.


CONCLUSIONS
This study provides a significant try for studying the compatibility of composite herbal medicines.
Song
Zong-hua
ZH
Shenyang Pharmaceutical University, Shenyang 110015, Liaoning, China.
Dai
Shu-jia
SJ
Li
Hui-qin
HQ
Bi
Kai-shun
KS
Feng
Dong
D
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D004232:Diuretics / Q000494:pharmacology; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use; D005260:Female; D000860:Hypoxia / Q000188:drug therapy; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry; D014693:Ventricular Fibrillation / Q000188:drug therapy
D000889:Anti-Arrhythmia Agents; D004232:Diuretics; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C457640:ling-gui-zhu-gan decoction