title: Comparison of pulp responses to resin composites.
abstract: Diverse reports have described how various types of adhesive systems cause disastrous pulp necrosis, chronic severe inflammation or failure to stimulate any pulp reactions. This article reports on the effects of five common adhesive systems and how they compare in terms of pulp injury as measured by odontoblast survival or dentin regeneration and reactionary dentin formation. One hundred and thirty Class V pulp, non-exposed cavities were prepared in non-human primate teeth and were restored with five different adhesive systems. After a period of time between 3 and 172 days, the teeth were extracted, fixed, processed and examined histomorphometrically. Bacterial microleakage was detected with McKays stain and inflammation was categorized according to the International Organization for Standardization (ISO) criteria. The number of odontoblasts and the area of reactionary dentin were measured. Pulp reactions of all adhesive systems were generally minimal, although some systems permitted bacterial microleakage in 33% of restorations, and some other systems were associated with pulp inflammation in 22% of restorations. These observations suggest that adhesive systems provide acceptable biocompatibility, however, there is strong potential for improvement.
authors.affiliation: College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA. pemurray@nova.edu
authors.forename: P E
authors.initials: PE
authors.lastname: Murray
authors.forename: L J
authors.initials: LJ
authors.lastname: Windsor
authors.forename: A A
authors.initials: AA
authors.lastname: Hafez
authors.forename: R G
authors.initials: RG
authors.lastname: Stevenson
authors.forename: C F
authors.initials: CF
authors.lastname: Cox
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D002470:Cell Survival; D016009:Chi-Square Distribution; D003188:Composite Resins / Q000494:pharmacology*; D003737:Dental Cavity Preparation; D003763:Dental Leakage / Q000382:microbiology; D003782:Dental Pulp / Q000187:drug effects* / Q000473:pathology; D003793:Dental Restoration, Permanent; D003804:Dentin / Q000187:drug effects / Q000473:pathology; D003809:Dentin, Secondary / Q000187:drug effects / Q000473:pathology; D017220:Dentin-Bonding Agents / Q000494:pharmacology*; D008253:Macaca mulatta; D008689:Methacrylates / Q000494:pharmacology; D009804:Odontoblasts / Q000187:drug effects / Q000473:pathology; D011671:Pulpitis / Q000139:chemically induced / Q000473:pathology; D019279:Resin Cements / Q000494:pharmacology
chemical_list: C070606:Amalgambond; D001672:Biocompatible Materials; D003188:Composite Resins; D017220:Dentin-Bonding Agents; C469712:Liner Bond III; D008689:Methacrylates; C092987:Optibond; D019279:Resin Cements; C067788:scotchbond 2; C100742:All-Bond 2