New insights into a persistent problem -- chlamydial infections.
Tissue tropism of clinical ocular and genital Chlamydia trachomatis strains is shown to be linked to the tryptophan synthase genotype. It is suggested that, in the presence of IFN-gamma, which depletes available tryptophan, there exist unique host-parasite interactions that may contribute to persistent chlamydial infection.
Morrison
Richard P
RP
Department of Microbiology, Montana State University, Bozeman, Montana 59717, USA. morrison@montana.edu
D002690:Chlamydia Infections / Q000235:genetics* / Q000628:therapy*; D005260:Female; D005836:Genitalia, Female / Q000382:microbiology; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D008954:Models, Biological; D014367:Tryptophan Synthase / Q000235:genetics*
D007371:Interferon-gamma; D014367:Tryptophan Synthase