title: Lupus anticoagulant associated with transient severe factor X deficiency: a report of two patients presenting with major bleeding complications.
abstract: Acquired factor X (FX) deficiency is rare, but has been reported in diverse disease states, including systemic amyloidosis and respiratory infections. FX deficiency associated with lupus anticoagulant (LA) and a bleeding diathesis has not been previously reported. We report two patients both of whom presented with a severe bleeding diathesis after a preceding respiratory infection due to isolated FX deficiency associated with a LA. The FX deficiency and LA were transient. We conclude that patients with LA may rarely present with severe acquired FX deficiency. This may be another mechanism whereby patients with antiphospholipid antibodies present with bleeding complications.
authors.affiliation: Department of Medicine, Division of Hematology, Oncology and Transplantation, and Department of Laboratory Medicine and Pathology of the University of Minnesota Medical School, Minneapolis, MN 55455, USA. ashra002@tc.umn.edu
authors.forename: Aneel A
authors.initials: AA
authors.lastname: Ashrani
authors.forename: Agnes
authors.initials: A
authors.lastname: Aysola
authors.forename: Hani
authors.initials: H
authors.lastname: Al-Khatib
authors.forename: William L
authors.initials: WL
authors.lastname: Nichols
authors.forename: Nigel S
authors.initials: NS
authors.lastname: Key
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000097:blood; D005171:Factor X Deficiency / Q000209:etiology*; D006474:Hemorrhagic Disorders / Q000209:etiology*; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000150:complications
chemical_list: D017152:Antibodies, Antiphospholipid; D016682:Lupus Coagulation Inhibitor