Molecular skin barrier models and some central problems for the understanding of skin barrier structure and function.
A better understanding of the structure and function of the human skin barrier is a prerequisite for a more rational design of transdermal drug administration systems. The study of biological structural organisation is, however, confronted with many difficulties, and interpretations of skin barrier-related data should therefore be done with caution. The recently developed 'single gel-phase model' constitutes an attempt to interpret structural and functional skin barrier data from a biophysical standpoint.
Norlén
L
L
Group of Applied Physics - Biomedical, Department of Physics, University of Geneva, Geneva, Switzerland. lars.norlen@physics.unige.ch
D006801:Humans; D008954:Models, Biological; D010539:Permeability; D012867:Skin / Q000033:anatomy & histology* / Q000378:metabolism; D012869:Skin Absorption; D012879:Skin Physiological Phenomena