title: Deep resting glabellar rhytides respond to BTX-A and Hylan B.
abstract: BACKGROUND
  BTX-A is the standard treatment for glabellar furrows. However, some individuals have resting glabellar rhytides that are sufficiently deep that they respond poorly to BTX-A alone.
  
  
  OBJECTIVE
  To compare the efficacy of BTX-A combined with intradermal Hylan B with the efficacy of BTX-A alone in individuals with moderate to severe glabellar rhytides.
  
  
  METHODS
  This was a retrospective study of 16 subjects with moderate to severe glabellar rhytides. Their response to Hylan B plus BTX-A was compared clinically and photographically to their response to BTX-A alone.
  
  
  RESULTS
  All subjects had moderate or severe glabellar rhytides at rest before treatment. After BTX-A alone, none (0%) had achieved no or mild rhytides. After BTX-A and Hylan B injection, only 1 of 16 (6%) had moderate glabellar rhytides, with the remainder (94%) being mild.
  
  
  CONCLUSIONS
  Moderate to severe glabellar rhytides were treated better by BTX-A combined with Hylan B injection than by BTX-A alone.
authors.affiliation: Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada. drjean@carruthers.net
authors.forename: Jean
authors.initials: J
authors.lastname: Carruthers
authors.forename: Alastair
authors.initials: A
authors.lastname: Carruthers
authors.forename: David
authors.initials: D
authors.lastname: Maberley
mesh_terms: D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005546:Forehead; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage*; D012189:Retrospective Studies; D015595:Skin Aging / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D009465:Neuromuscular Agents; C445362:hylan-B gel; D006820:Hyaluronic Acid; D019274:Botulinum Toxins, Type A