[Effects of microcirculatory disorders of inner ear on blood-labyrinth barrier permeability in guinea pigs].
OBJECTIVE
To study the changes of blood-labyrinth barrier permeability during cochlea microcirculatory disorders in guinea pigs.


METHODS
Using modified method of Evan's blue fluorescence, the changes of permeability of blood-labyrinth barrier were observed in the animal model of cochlea microcirculatory disorders which was induced by photochemical reaction.


RESULTS
Amount of Evan's blue passing through the blood-labyrinth barrier was (1.709 +/- 0.769) microgram per guinea pig after 2 hours and (2.849 +/- 0.653) microgram per guinea pig after 4 hours when the cochlea was in microcirculatory disorder.


CONCLUSIONS
The results indicated that the permeability of blood-labyrinth barrier increased when cochlea microcirculatory disorders occurred and the increase of blood-labyrinth barrier permeability may be one of the important mechanisms which causes the cochlear ischemic lesions.
Zhang
X
X
Department of Otorhinolaryngology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. yingsc@public.cta.cq.cn
Wang
J
J
D000818:Animals; D002199:Capillary Permeability; D007758:Ear, Inner / Q000098:blood supply*; D005260:Female; D006168:Guinea Pigs; D007511:Ischemia / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation