title: Brain perfusion SPECT in patients with corticobasal degeneration: analysis using statistical parametric mapping.
abstract: We sought to determine the characteristics of brain perfusion in patients with corticobasal degeneration (CBD) using single photon emission computed tomography (SPECT) and statistical parametric mapping (SPM). Thirteen patients with CBD and 10 age-matched healthy volunteers were examined using brain perfusion SPECT and (99m)Tc-ethyl cysteinate dimer (ECD). Regional cerebral blood flow (rCBF) measurements were performed noninvasively using a graphic analysis method. Both the absolute rCBF data (raw data) and the adjusted rCBF data (global CBF normalized to 50 ml/100 g/min) were used in the SPM analysis. A significant decrease in the absolute rCBF was observed in extended areas of the brain in CBD patients compared to the control group. These areas included the frontal, parietal, and temporal cortices; basal ganglia; thalamus; and pontocerebellar regions. Our results suggest that the extent of the reduced rCBF region in CBD patients is more widespread than previously reported.
authors.affiliation: Department of Radiology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: A K M Moinul
authors.initials: AK
authors.lastname: Hossain
authors.forename: Yuji
authors.initials: Y
authors.lastname: Murata
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Taura
authors.forename: Yukinobu
authors.initials: Y
authors.lastname: Saitoh
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Mizusawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Oda
authors.forename: Eisuke
authors.initials: E
authors.lastname: Matsushima
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Okubo
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shibuya
mesh_terms: D000368:Aged; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000473:pathology*; D001480:Basal Ganglia Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods*; D016022:Case-Control Studies; D002540:Cerebral Cortex; D002560:Cerebrovascular Circulation; D003545:Cysteine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015609:Organotechnetium Compounds; D011875:Radionuclide Angiography; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine