title: Biological predictors of treatment response in affective illness.
abstract: Attempts to identify biological response predictors generally have met with limited success, particularly where the goal is to develop clinically useful indices. This article reviews the biological approaches to predicting treatment response, beginning with neuroendocrine studies and electroencephalogram analysis and concluding with structural and functional neuroimaging. The article describes the designs of typical studies to aid in interpreting their results and concludes by addressing some of the problems and limitations associated with these approaches and suggesting future directions for this research.
authors.affiliation: Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman Street, WACC 812, Boston, MA 02114, USA. rperlis@partners.org
authors.forename: Roy H
authors.initials: RH
authors.lastname: Perlis
authors.forename: Dan V
authors.initials: DV
authors.lastname: Iosifescu
authors.forename: Perry F
authors.initials: PF
authors.lastname: Renshaw
mesh_terms: D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography; D005071:Evoked Potentials; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D019964:Mood Disorders / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D009490:Neurosecretory Systems / Q000503:physiopathology; D011379:Prognosis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome