title: In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum.
abstract: The in vitro antimalarial activity against Plasmodium falciparum and heme polymerization were evaluated for ten metalloporphyrins: gallium protoporphyrin IX (GaPPIX), sodium salt of gallium protoporphyrin IX, silver protoporphyrin IX, palladium protoporphyrin IX, cobalt protoporphyrin IX, manganese protoporphyrin IX, tin protoporphyrin IX (SnPPIX), chromium protoporphyrin IX, gallium deuteroporphyrin IX (GaDPIX) and gallium hematoporphyrin IX. Metalloporphyrins inhibited parasite growth with 50% inhibitory concentrations (IC(50)) ranging from 15.5 microM to 190 microM. In trophozoite lysate-mediated heme polymerization assays, SnPPIX, GaPPIX and GaDPIX exerted potent inhibitory activity similar to that of artemisinin and chloroquine.
authors.affiliation: Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700-8530, Japan.
authors.forename: Khurshida
authors.initials: K
authors.lastname: Begum
authors.forename: Hye-Sook
authors.initials: HS
authors.lastname: Kim
authors.forename: Veena
authors.initials: V
authors.lastname: Kumar
authors.forename: Igor
authors.initials: I
authors.lastname: Stojiljkovic
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Wataya
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D006418:Heme / Q000378:metabolism*; D016778:Malaria, Falciparum / Q000469:parasitology; D008665:Metalloporphyrins / Q000737:chemistry / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D011108:Polymers / Q000378:metabolism
chemical_list: D000962:Antimalarials; D008665:Metalloporphyrins; D011108:Polymers; D006418:Heme