Dietary fish oil does not protect rats exposed to restraint or sleep deprivation stress.
It has been suggested that fish oil (FO) prevents weight loss caused by physiological stress such as cancer, injury, or cardiovascular disorders. Previously, we observed that a high-fat diet containing corn and coconut oil exaggerated weight loss caused by the mixed physiological and psychological stress of repeated restraint (RR). This experiment tested the effects of a high-fat diet containing FO as the predominant lipid source in rats exposed to the mixed physiological and psychological stress of either RR or sleep deprivation (SD). FO did not prevent stress-induced hypophagia or weight loss in RR or SD rats but exaggerated the negative effects of stress on body weight in SD rats by promoting loss of lean body mass. RR caused a reduction in body fat content irrespective of dietary treatment. In SD rats, both stress and FO independently reduced body fat mass. FO did not have any effect on adrenal and thymus weights during RR or SD and did not influence corticosterone levels after 1 h of RR or after 48 or 96 h of SD. In conclusion, our results suggest that high levels of dietary FO do not improve the response to stress in rats exposed to mixed stressors.
Papakonstantinou
Emilia
E
Department of Foods and Nutrition, University of Georgia, Dawson Hall, Athens, GA 30602, USA. apapas@arches.uga.edu
Ryan
Donna H
DH
Harris
Ruth B S
RB
D000273:Adipose Tissue / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001823:Body Composition / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000187:drug effects; D003072:Cognition Disorders / Q000503:physiopathology / Q000523:psychology; D003345:Corticosterone / Q000097:blood; D004032:Diet; D004435:Eating / Q000187:drug effects; D005395:Fish Oils / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical / Q000523:psychology*; D012892:Sleep Deprivation / Q000503:physiopathology*; D013315:Stress, Psychological / Q000503:physiopathology* / Q000517:prevention & control / Q000523:psychology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D015431:Weight Loss / Q000187:drug effects / Q000502:physiology
D005395:Fish Oils; D014409:Tumor Necrosis Factor-alpha; D003345:Corticosterone