title: [Values of soluble thrombomodulin and von Willebrand factor judging reject reaction in liver transplantation].
abstract: OBJECTIVE
  To find sensitive and specific laboratory examination items for early diagnosing and monitoring liver transplantation reject reaction.
  
  
  METHODS
  Randomly investigate 41 liver transplantation patients, among them there were 16 patients with reject reaction (including 12 with acute rejection, 4 with chronic rejection). Plasma soluble thrombomodulin (STM) and von Willebrand factor (vWF) levels were measured before operation and every other day after operation.
  
  
  RESULTS
  Plasma STM level increased significantly after operation, two days before rejection and after acute rejection (5.58 ng/ml +/- 0.42 ng/ml, 5.93 ng/ml +/- 0.45 ng/ml, and 7.88 ng/ml +/- 0.29 ng/ml, respectively), so did vWF level (101.2% +/- 4.68%, 104.3% +/- 5.78%, and 127.7% +/- 5.74%, respectively). STM level was much higher in acute rejection than that in chronic rejection (7.88 ng/ml +/- 0.29 ng/ml vs. 6.35 ng/ml +/- 0.54 ng/ml, t = 2.46, P < 0.05), in no reaction group after impacting therapy than in effective group (8.30 ng/ml +/- 0.19 ng/ml vs. 3.82 ng/ml +/- 0.22 ng/ml, t = 12.98, P < 0.01), and in dead group after treatment than in living group (7.98 ng/ml +/- 0.18 ng/ml vs. 6.51 ng/ml +/- 0.41 ng/ml, t = 3.39, P < 0.01).
  
  
  CONCLUSIONS
  Plasma STM and vWF can be taken as laboratory items for monitoring liver transplantation rejection. Plasma STM can act as not only an early prognosticating marker, but also suitable to distinguish acute from chronic reject reaction, and as a marker for monitoring impacting therapy effect and judging prognosis.
authors.affiliation: Department of Hematology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Chun-guang
authors.initials: CG
authors.lastname: Wen
authors.forename: Shao-kai
authors.initials: SK
authors.lastname: Luo
authors.forename: Xiao-shun
authors.initials: XS
authors.lastname: He
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.forename: Wai-yi
authors.initials: WY
authors.lastname: Zou
authors.forename: Ai-hua
authors.initials: AH
authors.lastname: Peng
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006084:Graft Rejection; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D018180:Thrombomodulin / Q000097:blood*; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D015415:Biomarkers; D018180:Thrombomodulin; D014841:von Willebrand Factor