title: Successful treatment of Candida krusei infection with caspofungin acetate: a new antifungal agent.
abstract: OBJECTIVE
  Systemic fungal infections have high mortality, and therapy is often toxic. Caspofungin acetate, a new antifungal agent with minimal toxicity, may provide a better alternative to typical therapy for Candida krusei.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Multidisciplinary intensive care unit (ICU) of a community teaching hospital.
  
  
  METHODS
  A 22-yr-old male with acute lymphoblastic leukemia and Candida krusei fungemia failed therapy with fluconazole and amphotericin B.
  
  
  METHODS
  Caspofungin acetate given intravenously as a 70-mg loading dose, followed up by 50 mg daily along with standard ICU care.
  
  
  RESULTS
  Survival without toxicity from therapy.
  
  
  CONCLUSIONS
  Efficacy of caspofungin acetate in a patient with life-threatening Candida Krusei infection.
authors.affiliation: Department of ICU Quality Improvement, Baystate Medical Center, Springfield, MA 01199, USA. william.mcgee@bhs.org
authors.forename: William T
authors.initials: WT
authors.lastname: McGee
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Tereso
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002175:Candida / Q000145:classification; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D000077336:Caspofungin; D054714:Echinocandins; D015725:Fluconazole / Q000627:therapeutic use; D016469:Fungemia / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007262:Infusions, Intravenous; D055666:Lipopeptides; D008297:Male; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications; D009894:Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D010455:Peptides; D010456:Peptides, Cyclic; D010996:Pleural Effusion / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010455:Peptides; D010456:Peptides, Cyclic; D000666:Amphotericin B; D015725:Fluconazole; D000077336:Caspofungin