title: The evidence for GABAB receptor-mediated regulation of acid-base balance: involvement of Na+/H+ exchanger and Na+/HCO3- cotransporter.
abstract: A comparative analysis of the effects of gamma-aminobutyric acid (GABA) on the expressions of Na+/H+ exchanger 1 (NHE1) and Na+/HCO3- cotransporter (NBC) was investigated in order to extend our understanding of the mechanism of GABA receptor-mediated acid-base balance using a gerbil model. In vigabatrin (VGB, GABA degradation inhibitor) treated gerbils, both NHE1 and NBC immunoreactivities in the hippocampus were significantly elevated, as compared with the controls. Analogous to VGB treatment, baclofen (GABAB receptor agonist) treatment also evoked elevations of both NHE1 and NBC expressions in the hippocampus, whilst their expressions were unaffected by muscimol (GABAA receptor agonist) treatment. Therefore, our findings suggest that GABAB receptor-mediated regulation of NHE1 and NBC expressions may participate in acid-base balance in the gerbil hippocampus.
authors.affiliation: Department of Anatomy, College of Medicine, Hallym University, Chunchon, Kangwon-Do, 200-702, South Korea. tckang@hallym.ac.kr
authors.forename: Tae-Cheon
authors.initials: TC
authors.lastname: Kang
authors.forename: Sung-Jin
authors.initials: SJ
authors.lastname: An
authors.forename: Seung-Kook
authors.initials: SK
authors.lastname: Park
authors.forename: In-Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Jae Chun
authors.initials: JC
authors.lastname: Bae
authors.forename: Moo Ho
authors.initials: MH
authors.lastname: Won
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018755:GABA Agonists / Q000494:pharmacology; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism*; D009118:Muscimol / Q000494:pharmacology; D018080:Receptors, GABA-B / Q000378:metabolism*; D027982:Sodium-Bicarbonate Symporters / Q000378:metabolism*; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism*; D020888:Vigabatrin / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D018755:GABA Agonists; D018080:Receptors, GABA-B; D027982:Sodium-Bicarbonate Symporters; D017923:Sodium-Hydrogen Exchangers; C069139:growth factor-activatable Na-H exchanger NHE-1; D009118:Muscimol; D020888:Vigabatrin; D001418:Baclofen