[Value of regional intra-arterial induction chemotherapy for locally advanced nasopharyngeal carcinoma].
OBJECTIVE
To define the value of regional intra-arterial induction chemotherapy for locally advanced nasopharyngeal carcinoma (NPC).


METHODS
121 locally advanced NPC(stage III-IV) patients confirmed by pathology were randomly divided into two groups before radiation, and the two groups were given two different methods of chemotherapy: regional intra-arterial chemotherapy (IACT) and systemic chemotherapy (SCT). After radiation the effect of two methods was compared.


RESULTS
The complete response rates were 27.9% in the IACT and 11.7% in the SCT, and 5 years survival rates were 63.9% in the IACT and 45.0% in the SCT respectively. The differences of two groups were significant.


CONCLUSIONS
IACT is more reasonable than SCT as induction chemotherapy for these locally advanced NPC.
Jiang
G
G
Department of Otorhinolaryngology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
Min
H
H
Zhang
J
J
Huang
Y
Y
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D015996:Survival Rate
D000970:Antineoplastic Agents