title: New lysophosphatidylcholines and monoglycerides from the marine sponge Stelletta sp.
abstract: Two new lysophosphatidylcholines (1, 2) and four new monoglycerides (5-8) were isolated from the marine sponge Stelletta sp. by bioactivity-guided fractionation. The planar structures of the new compounds were established on the basis of NMR and MS analyses. The stereochemistry was defined by comparison of the optical rotation. The compounds were evaluated for cytotoxicity against a small panel of five human tumor cell lines.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Korea.
authors.forename: Qingchun
authors.initials: Q
authors.lastname: Zhao
authors.forename: Tayyab A
authors.initials: TA
authors.lastname: Mansoor
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Chong-O
authors.initials: CO
authors.lastname: Lee
authors.forename: Kwang Sik
authors.initials: KS
authors.lastname: Im
authors.forename: Dong Seok
authors.initials: DS
authors.lastname: Lee
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005989:Glycerides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms; D008244:Lysophosphatidylcholines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010051:Ovarian Neoplasms; D010713:Phosphatidylcholines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D005989:Glycerides; D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; C478193:stellettacholine A; C478194:stellettacholine B