title: [Renal capsuloma: description of a case with predominantly muscular differentiation].
abstract: The Authors report a case of Renal Capsuloma with a histologic biphasic pattern constituted of epithelioid and spindle cells. The lesion is observed in a nephrectomy specimen as incidental finding concurrent with a Papillary Transitional Cell Carcinoma of calices and renal pelvis. The lesion presents a distinct muscular immunophenotype (actin+, desmin+), with coexpression of the melanogenesis marker (HMB45+) in a lower cellular population. This combined immunophenotype is a characteristic feature of the Perivascular Epithelioid Cell's (PEC) lesions. Actually Renal Capsuloma is a PEC's lesion (Pecoma) closely related to Angiomyolipoma (AML). Particularly Capsuloma is thought as a variant of AML predominantly composed by muscular spindle cells (monotypic spindle cell-leiomyoma like variant of AML). In the presented case the spindle cell component is associated with an epithelioid cellular population which also shows a distinct muscular differentiation. The Authors have not found in the literature the association between Renal Capsuloma and Papillary Transitional Cell Carcinoma of the renal pelvis.
authors.affiliation: Dipartimento di Oncologia, U.O. di Anatomia Patologica, Azienda Ospedaliera G. Rummo, Benevento. arturodiblasi@virgilio.it
authors.forename: A
authors.initials: A
authors.lastname: Di Blasi
authors.forename: G
authors.initials: G
authors.lastname: Ferrara
authors.forename: P
authors.initials: P
authors.lastname: Gogglia
mesh_terms: D000199:Actins / Q000032:analysis; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor / Q000032:analysis; D002295:Carcinoma, Transitional Cell / Q000473:pathology; D002454:Cell Differentiation; D003893:Desmin / Q000032:analysis; D015622:Epithelioid Cells / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D007680:Kidney Neoplasms / Q000737:chemistry / Q000473:pathology*; D008297:Male; D058950:Melanoma-Specific Antigens; D008875:Middle Aged; D009214:Myoma / Q000737:chemistry / Q000473:pathology*; D009363:Neoplasm Proteins / Q000032:analysis; D009378:Neoplasms, Multiple Primary / Q000473:pathology*
chemical_list: D000199:Actins; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D003893:Desmin; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins