title: Management of recurrent colorectal carcinoma.
abstract: BACKGROUND/OBJECTIVE: The records of patients treated for adenocarcinoma of the colon and rectum between 1 January 1988 and 31 December 1995 at Naval Medical Center San Diego were reviewed. Analysis was made of patients who developed recurrences after potentially definitive primary therapy. METHODS: A retrospective review of 410 patients diagnosed with colorectal cancer at our institution was conducted. The focus of this review was to identify patients with recurrent disease after curative initial procedures, and to determine how recurrences were detected and treated. Survival data for 48 patients undergoing various curative and palliative procedures, or no therapy, were generated. RESULTS: The decision to re-operate with curative intent was made after a multidisciplinary review of restaging studies. Laparoscopy was not used in this determination. Curative resection of recurrence confers increased survival over non-curative surgery and no surgery (P < 0.001). This is misleading because of patient selection; several patients undergo potentially curative surgery but are determined intraoperatively to best be palliated, or to have further surgery aborted. Analysis of results in patients undergoing potentially curative surgery vs. those undergoing planned palliation vs. those not operated reveals that these also provide significantly different outcomes (P < 0.003). CONCLUSIONS: Proper delineation of resectable lesions in patients with recurrent colorectal cancer contributes to better outcomes for them. That determination is difficult, and efforts are underway in our institution and elsewhere to better delineate which patients are optimal preoperatively. We consider multidisciplinary Tumor Board evaluation to be central to this process.
authors.affiliation: General Surgery and Clinical Investigation Departments and Radiation Oncology Division, Naval Medical Center, San Diego, CA and Radiation Oncology Division, University of California, San Diego, CA, USA.
authors.forename: S. A
authors.initials: SA
authors.lastname: Brethauer
authors.forename: T. J
authors.initials: TJ
authors.lastname: Magrino
authors.forename: R. H
authors.initials: RH
authors.lastname: Riffenburgh
authors.forename: P. A. S
authors.initials: PA
authors.lastname: Johnstone