[Osteopontin and arthritis].
Osteopontin is an RGDS-containing protein which acts as an intercellular signaling molecule as well as a cellular attachment protein. Expression of osteopontin has been observed in the joints of patients with rheumatoid arthritis as well as osteoarthritis. However, the functions of osteopontin in such diseased articular components have not yet been elucidated. Recent investigations using knockout mice lacking osteopontin indicated that the presence of osteopontin could play a role in the development of arthritis induced by injection with monoclonal antibodies raised against type II collagen.
Noda
Masaki
M
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University.
Yumoto
Kenji
K
Morinobu
Mikihiko
M
Tsuji
Kunikazu
K
Nifuji
Akira
A
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000209:etiology*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D053495:Osteopontin; D012795:Sialoglycoproteins / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
C506895:SPP1 protein, human; D012795:Sialoglycoproteins; C506896:Spp1 protein, mouse; D053495:Osteopontin