title: Emotions are building up in the field of extracellular proteolysis.
abstract: Activity-dependent remodeling of neural connections might require localized extracellular proteolysis. The tissue-type plasminogen activator (tPA)-plasmin proteolytic system is expressed in different regions of the central nervous system, in the context of a variety of physiological and pathological processes. Accumulating evidence regarding the expression and role of tPA and its inhibitors suggests that extracellular proteolysis is a key player in the biology of memory, emotions and neurodegeneration.
authors.affiliation: Institute of Anatomy, University of Zurich, Winterthurerstr. 190, 8057 Zurich, Switzerland.
authors.forename: Rime
authors.initials: R
authors.lastname: Madani
authors.forename: Serge
authors.initials: S
authors.lastname: Nef
authors.forename: Jean Dominique
authors.initials: JD
authors.lastname: Vassalli
mesh_terms: D000818:Animals; D004644:Emotions / Q000502:physiology*; D051379:Mice; D009420:Nervous System / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism; D015843:Serpins / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000378:metabolism*; D000097522:Neuroserpin
chemical_list: D009479:Neuropeptides; D015843:Serpins; D010959:Tissue Plasminogen Activator; D000097522:Neuroserpin