title: A study on the synthesis of antiangiogenic (+)-coronarin A and congeners from (+)-sclareolide.
abstract: Coronarin A 1, epi-coronarin A 2 and some synthetic intermediates 14a and 14b synthesized from sclareolide exhibit good growth inhibition activities on HUVEC proliferation. In particular, coronarin A 1 and epi-coronarin A 2 effectively suppressed the growth factor induced tube formation of HUVEC at the concentration of 10 micro g/mL.
authors.affiliation: Department of Chemistry, Yonsei University, Wonju 220-710, South Korea.
authors.forename: Sangtae
authors.initials: S
authors.lastname: Oh
authors.forename: In Howa
authors.initials: IH
authors.lastname: Jeong
authors.forename: Woon Seob
authors.initials: WS
authors.lastname: Shin
authors.forename: Seokjoon
authors.initials: S
authors.lastname: Lee
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018919:Neovascularization, Physiologic / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014471:Umbilical Veins / Q000166:cytology; D042442:Vascular Endothelial Growth Factors / Q000037:antagonists & inhibitors
chemical_list: D020533:Angiogenesis Inhibitors; D004224:Diterpenes; D005663:Furans; D009281:Naphthalenes; D042442:Vascular Endothelial Growth Factors; C481378:coronarin A; C109395:sclareolide