Plasma amyloid beta protein 1-42 levels are increased in old Down Syndrome but not in young Down Syndrome.
Plasma amyloid beta protein 1-40 (Abeta40) and Abeta42 levels were quantitated from 28 young Down syndrome (DS) (20-40 years old), 28 age-matched controls, 32 old DS (41-65 years old) and 32 age-matched controls in a sandwich enzyme-linked immunosorbent assay. Abeta40 levels were higher in young DS and old DS than controls. Abeta42 levels in young DS and controls were similar, however Abeta42 levels were higher in old DS than controls or young DS. The higher Abeta42 levels in old DS suggests that Abeta42 is selectively increased in plasma concurrently with the development of Alzheimer disease neuropathology.
Mehta
Pankaj D
PD
Division of Immunology, Department of Developmental Neurobiology, Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314-6399, USA. pdmehta@worldnet.att.net
Mehta
Sangita P
SP
Fedor
Betty
B
Patrick
Bruce A
BA
Emmerling
Mark
M
Dalton
Arthur J
AJ
D000328:Adult; D000375:Aging / Q000097:blood*; D016229:Amyloid beta-Peptides / Q000097:blood*; D016022:Case-Control Studies; D004314:Down Syndrome / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D018709:Statistics, Nonparametric
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42)