title: [Immunocytochemical study of gamma-aminobutyric acid-ergic innervation in the end-organs of human vestibule].
abstract: OBJECTIVE
  To investigate gamma-aminobutyric acid-ergic (GABAergic) innervation in the end-organs of human vestibule.
  
  
  METHODS
  A modified pre-embedding immunostaining technique of immunoelectron microscopy were applied to accomplish this study with a polyclonal antibody to gamma-aminobutyric acid.
  
  
  RESULTS
  GABA-immunoreactive products were confined to the nerve terminals, which were rich in synaptic vesicles and the non-myelinated fibers. The GABA-immunoreactive nerve fibers synapse with afferent calices surrounding the type I hair cells.
  
  
  CONCLUSIONS
  This study shows that GABAergic fibers of human vestibular end-organs belong to the vestibular efferent system.
authors.affiliation: University of Innsbruck, Austria and Department of Otorhinolaryngology Union Hospital, Tongji Medical University, Wuhan 430022.
authors.forename: W
authors.initials: W
authors.lastname: Kong
authors.forename: B
authors.initials: B
authors.lastname: Hussl
authors.forename: A
authors.initials: A
authors.lastname: Schrott-Fischer
mesh_terms: D006801:Humans; D016253:Microscopy, Immunoelectron; D014725:Vestibular Nerve / Q000737:chemistry* / Q000648:ultrastructure; D014722:Vestibule, Labyrinth / Q000294:innervation / Q000648:ultrastructure*; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid