[Mechanisms disordering wound healing on the lip after bilateral crossing of the inferior alveolar nerve and experimental validation of correction methods].
The mechanisms of lip wound healing after bilateral crossing of the inferior alveolar nerve (IAN) were studied on Chinchilla rabbits in 3 experimental series, 6 animals per series. In group 1 bilateral crossing of IAN was carried out, in group 2 bilateral crossing of IAN was paralleled by removal of a mucous flap in the middle of the lower lip, and in group 3 the same wound as in group 2 was created, after which the wounds in this group were daily treated with a special ointment and a single injection of lidocaine (1% solution) under the wound. The nerve crossing led to development of ulcer on the lip with degenerative changes in the vascular walls, destruction of nerve fibers, and fragmentation of some axial cylinders. Crossing of IAN simultaneously with removal of the lower lip flap led to more severe degenerative changes in the tissue. Daily treatment of the lip with the ointment and lidocaine blocking normalized wound healing. A possible mechanism of the changes observed is discussed.
Volozhin
A I
AI
Brusenina
N D
ND
Gemonov
V V
VV
Rybalkina
E A
EA
Druzhinina
R  A
R
D000779:Anesthetics, Local / Q000627:therapeutic use; D000818:Animals; D008012:Lidocaine / Q000627:therapeutic use; D008046:Lip / Q000294:innervation* / Q000473:pathology / Q000503:physiopathology; D008047:Lip Diseases / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D008340:Mandibular Nerve / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D061221:Trigeminal Nerve Injuries; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
D000779:Anesthetics, Local; D008012:Lidocaine