title: Naturally-farrowed, artificially-reared pigs as an alternative model for experimental infection by Haemophilus parasuis.
abstract: The use of naturally-farrowed, artificially-reared piglets as an alternative model to study Haemophilus parasuis infections was evaluated. Two trials were performed in order to evaluate the proposed model. In trial 1, animals were vaccinated and challenged with H. parasuis. Results showed that the proposed model was effectively used to evaluate protective immunity against this organism. In trial 2, animals were challenged with different doses of H. parasuis. Results showed that the severity of clinical signs and lesions tended to increase with higher doses. The reproduction of clinical signs and lesions characteristic of H. parasuis systemic infection was successful in both trials, proving that this model is a viable alternative to specific-pathogen free and cesarean-derived, colostrum-deprived pigs.
authors.affiliation: Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, 1988 Fitch Ave, Animal Science Veterinary Medicine Building, Saint Paul, Minnesota 55108, USA.
authors.forename: Simone
authors.initials: S
authors.lastname: Oliveira
authors.forename: Lucina
authors.initials: L
authors.lastname: Galina
authors.forename: Isabel
authors.initials: I
authors.lastname: Blanco
authors.forename: Ana
authors.initials: A
authors.lastname: Canals
authors.forename: Carlos
authors.initials: C
authors.lastname: Pijoan
mesh_terms: D000822:Animal Husbandry / Q000379:methods; D000818:Animals; D000831:Animals, Newborn; D001428:Bacterial Vaccines; D004195:Disease Models, Animal; D004306:Dose-Response Relationship, Immunologic; D005856:Germ-Free Life; D006190:Haemophilus / Q000276:immunology* / Q000472:pathogenicity; D006192:Haemophilus Infections / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D011897:Random Allocation; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000473:pathology* / Q000517:prevention & control; D014611:Vaccination / Q000662:veterinary
chemical_list: D001428:Bacterial Vaccines