title: Urea small molecule agonists on mouse melanocortin receptors.
abstract: A series of urea compounds based on the tripeptide Phe-Trp-Lys were synthesized and pharmacologically characterized at the mouse melanocortin receptors. The results include identification of novel melanocortin receptor agonists with potencies ranging from nanomolar to micromolar.
authors.affiliation: Department of Medicinal Chemistry, University of Florida, PO Box 100485, Gainesville, FL 32610, USA.
authors.forename: Christine G
authors.initials: CG
authors.lastname: Joseph
authors.forename: Rayna M
authors.initials: RM
authors.lastname: Bauzo
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Xiang
authors.forename: Carrie
authors.initials: C
authors.lastname: Haskell-Luevano
mesh_terms: D000818:Animals; D051379:Mice; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology; D044101:Receptors, Melanocortin / Q000819:agonists*; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D009842:Oligopeptides; D044101:Receptors, Melanocortin; D014508:Urea