title: Plasmablastic lymphoma presenting in a human immunodeficiency virus-negative patient: a case report.
abstract: Plasmablastic lymphoma (PBL), an aggressive non-Hodgkin's lymphoma that carries a poor prognosis, previously has been identified almost exclusively in patients infected with the human immunodeficiency virus (HIV). We present a case of a 42-year-old HIV-negative patient presenting with an isolated nasal cavity mass, the typical presentation for PBL. The patient was given systemic chemotherapy, central nervous system prophylaxis, and consolidative locoregional radiotherapy and achieved a complete clinical response. This case suggests PBL should be considered in HIV-negative patients with characteristic findings.
authors.affiliation: Division of Oncology, Department of Medicine, Stanford University School of Medicine, 703 Welch Road, Rm H4, Palo Alto, CA 94304, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Nguyen
authors.affiliation: Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: B W
authors.initials: BW
authors.lastname: Loo
authors.affiliation: Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: G
authors.initials: G
authors.lastname: Tillman
authors.affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Natkunam
authors.affiliation: Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Cao
authors.affiliation: Department of Surgery, Stanford University Medical Center, Stanford, CA, USA.
authors.forename: W
authors.initials: W
authors.lastname: Vaughan
authors.affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: R F
authors.initials: RF
authors.lastname: Dorfman
authors.affiliation: Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Goffinet
authors.affiliation: Division of Oncology, Department of Medicine, Stanford University School of Medicine, 703 Welch Road, Rm H4, Palo Alto, CA 94304, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Jacobs
authors.affiliation: Division of Oncology, Department of Medicine, Stanford University School of Medicine, 703 Welch Road, Rm H4, Palo Alto, CA 94304, USA. radvani@stanford.edu.
authors.forename: R H
authors.initials: RH
authors.lastname: Advani
mesh_terms: D000328:Adult; D018023:HIV Seronegativity; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000473:pathology