The anabolic-androgenic steroid nandrolone induces alterations in the density of serotonergic 5HT1B and 5HT2 receptors in the male rat brain.
Anabolic-androgenic steroids (AAS) are partly misused by males in order to become brave and intoxicated and these agents are highly associated with psychosis, disinhibition, aggression and acts of violence. Since such behavioral states have been related to an imbalanced serotonergic system and the involvement of the serotonergic 5HT(1B) and the 5HT(2) receptors, it was important to discern the impact of AAS on these receptors. The objective of our study was to investigate the effects of 2 weeks of treatment with the AAS nandrolone decanoate at three different doses (1, 5, 15 mg/kg/day) on the total specific binding of the radioligands [(125)I]-(+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) (5HT(2) receptors) by autoradiography. All doses caused a significant down-regulation of the 5HT(1B) receptor density in the hippocampal CA(1) and in the medial globus pallidus and a significant up-regulation of the 5HT(2) receptor density in the nucleus accumbens shell. Alterations in receptor density were also observed in the lateral globus pallidus, ventromedial hypothalamus, the amygdala and in the intermediate layers of various cortex regions. In conclusion, serotonergic 5HT(1B) or 5HT(2) receptors are likely to play important roles in mediating observed emotional states and behavioral changes among AAS abusers.
Kindlundh
A M S
AM
Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Box 591, S-751-24 Uppsala, Sweden. anna.kindlundh@farmbio.uu.se
Lindblom
J
J
Bergström
L
L
Nyberg
F
F
D045930:Anabolic Agents / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D002452:Cell Count; D015536:Down-Regulation; D004334:Drug Administration Schedule / Q000662:veterinary; D007215:Indophenol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D007456:Iodine Isotopes / Q000493:pharmacokinetics; D020120:Iodocyanopindolol / Q000493:pharmacokinetics; D008297:Male; D009277:Nandrolone / Q000378:metabolism / Q000494:pharmacology*; D011859:Radiography; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000493:pharmacokinetics; D017366:Serotonin Receptor Agonists / Q000493:pharmacokinetics
D045930:Anabolic Agents; D007456:Iodine Isotopes; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C113896:dimethoxy-4-indophenyl-2-aminopropane; D007215:Indophenol; D009277:Nandrolone; D020120:Iodocyanopindolol