Apoptosis in the prostate.
The prostate requires androgens for development and glandular maintenance, dying by the process of apoptosis following their removal. Anti-androgen therapy is targeted to induce this process but eventually fails with the emergence of an androgen independent cancer. These cells have development mechanisms to survive with out androgen impart due to the expression of anti-apoptotic factors.
Fitzpatrick
J M
JM
Department of Surgery, University College Dublin, Dublin, Ireland.
Watson
R W G
RW
D000728:Androgens / Q000502:physiology*; D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D008297:Male; D011467:Prostate / Q000502:physiology*
D000728:Androgens