Inherited thrombophilia and pregnancy loss.
A growing body of evidence obtained during the past 6 years suggests a significant role for inherited thrombophilia in the development of gestational vascular complications. Case-control and cross-sectional studies have demonstrated that thrombophilia is more prevalent in cohorts of women with pregnancy loss. Placental pathological findings in women with thrombophilia are hallmarked by thrombosis and fibrin deposition. Preliminary case-control studies suggest that low-molecular-weight heparins (LMWH) are effective in preventing pregnancy loss in women with thrombophilia and previous fetal wastage.
Brenner
Benjamin
B
Thrombosis and Haemostasis Unit, Department of Haematology, Rambam Medical Centre, P.O. Box 9602, Haifa 31096, Israel. s_kamenetsky@rambam.health.gov.il
D000026:Abortion, Habitual / Q000209:etiology* / Q000517:prevention & control; D000925:Anticoagulants / Q000627:therapeutic use; D005192:Family Health; D005260:Female; D005313:Fetal Death / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy / Q000209:etiology; D019851:Thrombophilia / Q000188:drug therapy / Q000235:genetics*
D000925:Anticoagulants