The reelin signaling pathway: some recent developments.
The Reelin signaling pathway plays a key role in the architectonic development of the central nervous system. Extracellular Reelin binds to receptors of the lipoprotein receptor family and induces tyrosine phosphorylation of the adaptor Dab1. In this paper, we discuss three recent developments. First, we show that the central part of Reelin is involved in receptor binding and signal activation as reflected in Dab1 phosphorylation. Second, we examine the genomic organization, alternative splicing and promoter use of the Dab1 gene, which hint at a particularly complex regulation. Third, we present preliminary studies by in situ hybridization that demonstrate regulated expression of Reelin receptors and Dab1 by radial precursors in the ventricular zone.
Jossin
Yves
Y
Developmental Genetics Unit, UCL GEDE 7382, 73 Avenue E. Mounier, B1200 Brussels, Belgium.
Bar
Isabelle
I
Ignatova
Nina
N
Tissir
Fadel
F
De Rouvroit
Catherine Lambert
CL
Goffinet
André M
AM
D015816:Cell Adhesion Molecules, Neuronal / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D002540:Cerebral Cortex / Q000196:embryology / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D026502:LDL-Receptor Related Proteins; D046911:Macromolecular Substances; D009419:Nerve Tissue Proteins; D009474:Neurons / Q000378:metabolism*; D011973:Receptors, LDL / Q000378:metabolism; D018110:Receptors, Lipoprotein / Q000378:metabolism; D000091042:Reelin Protein; D012697:Serine Endopeptidases; D015398:Signal Transduction / Q000502:physiology*
D015816:Cell Adhesion Molecules, Neuronal; C113062:DAB1 protein, Neurospora crassa; D016326:Extracellular Matrix Proteins; D005656:Fungal Proteins; D026502:LDL-Receptor Related Proteins; D046911:Macromolecular Substances; D009419:Nerve Tissue Proteins; D011973:Receptors, LDL; D018110:Receptors, Lipoprotein; D000091042:Reelin Protein; C036053:VLDL receptor; C098773:low density lipoprotein receptor-related protein 8; D012697:Serine Endopeptidases