title: Genetic strategies for antibacterial drug discovery.
abstract: The availability of genome sequences is revolutionizing the field of microbiology. Genetic methods are being modified to facilitate rapid analysis at a genome-wide level and are blossoming for human pathogens that were previously considered intractable. This revolution coincided with a growing concern about the emergence of microbial drug resistance, compelling the pharmaceutical industry to search for new antimicrobial agents. The availability of the new technologies, combined with many genetic strategies, has changed the way that researchers approach antibacterial drug discovery.
authors.affiliation: Department of Antimicrobial Therapy, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033-0530, USA. lynn.miesel@spcorp.com
authors.forename: Lynn
authors.initials: L
authors.lastname: Miesel
authors.forename: Jonathan
authors.initials: J
authors.lastname: Greene
authors.forename: Todd A
authors.initials: TA
authors.lastname: Black
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001681:Biological Assay; D004274:DNA, Recombinant; D015195:Drug Design; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005820:Genetic Testing; D016680:Genome, Bacterial; D023281:Genomics; D016296:Mutagenesis
chemical_list: D000900:Anti-Bacterial Agents; D004274:DNA, Recombinant