title: Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
abstract: tob is a member of antiproliferative family genes. Mice lacking tob are prone to spontaneous formation of tumors. The occurrence rate of diethylnitrosamine-induced liver tumors is higher in tob(-/-) mice than in wild-type mice. tob(-/-)p53(-/-) mice show accelerated tumor formation in comparison with single null mice. Expression of cyclin D1 mRNA is increased in the absence of Tob and is reduced by Tob. Tob acts as a transcriptional corepressor and suppresses the cyclin D1 promoter activity through an interaction with histone deacetylase. Levels of tob mRNA are often decreased in human cancers, implicating tob in cancer development.
authors.affiliation: Divisions of Oncology, Pathology, and Molecular Therapy, The Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Takahisa
authors.initials: T
authors.lastname: Nakamura
authors.forename: Masato
authors.initials: M
authors.lastname: Komoda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Satoh
authors.forename: Toru
authors.initials: T
authors.lastname: Suzuki
authors.forename: Junko K
authors.initials: JK
authors.lastname: Tsuzuku
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyasaka
authors.forename: Eri H
authors.initials: EH
authors.lastname: Yoshida
authors.forename: Hisashi
authors.initials: H
authors.lastname: Umemori
authors.forename: Reiko K
authors.initials: RK
authors.lastname: Kunisaki
authors.forename: Kenzaburo
authors.initials: K
authors.lastname: Tani
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Ishii
authors.forename: Shigeo
authors.initials: S
authors.lastname: Mori
authors.forename: Masami
authors.initials: M
authors.lastname: Suganuma
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Noda
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D009374:Neoplasms, Experimental / Q000209:etiology / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D025521:Tumor Suppressor Proteins
chemical_list: D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D012333:RNA, Messenger; C098669:TOB1 protein, human; C490903:Tob1 protein, mouse; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D019938:Cyclin D1; D006655:Histone Deacetylases