[An experimental study(I) on the inhibition of prostatic hyperplasia with extract of seeds of Brassica alba].
OBJECTIVE
To study the effective fraction of the extract of seeds of Brassica alba, which inhibits experimental mice prostatic hyperplasia.


METHODS
An experimental model of prostatic hyperplasia of castrated male mice induced by testosterone propionate was made. Fractions I, II and III were prepared by extracting the seeds of Brassica alba successively with ether, ethanol and water under reflux. Total extract was prepared by extracting the seeds of Brassica alba with 60% ethanol under reflux. The total extract and the three fractions were used to test the activities.


RESULTS
Total extract, fractions I and II could not only significantly inhibit mice prostatic hyperplasia induced by testosterone propionate and activity of serum acid phosphatase, but also decrease wet weight of preputial glands, while fraction III is inactive.


CONCLUSIONS
Extract from seeds of Brassica alba can significantly inhibit mice prostatic hyperplasia induced by exterior hormone, possessing an activity of anti-androgen. Fractions I and II show an equivalent activity of total extract, which indicate that these fractions contain active components of seeds of Brassica alba which can inhibit prostatic hyperplasia.
Wu
Guo-Xin
GX
Bioengineering College of Fujian Normal University, Fuzhou 350007, Fujian, China. wugx20021@sina.com
Lin
Yue-Xin
YX
Ou
Min-Rui
MR
Tan
Dong-Fei
DF
D000135:Acid Phosphatase / Q000097:blood*; D000818:Animals; D001937:Brassica / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D011467:Prostate / Q000187:drug effects*; D011470:Prostatic Hyperplasia / Q000097:blood / Q000139:chemically induced / Q000473:pathology*; D012639:Seeds / Q000737:chemistry; D013739:Testosterone
D004365:Drugs, Chinese Herbal; D013739:Testosterone; D000135:Acid Phosphatase