title: Antibiotic therapy in post-operative endophthalmitis.
abstract: Endophthalmitis following routine cataract surgery is a rare but potentially devastating complication resulting in severe vision loss. Various prophylaxis treatments have been tried. However, none have been demonstrated to completely eliminate the risk. The Endophthalmitis Vitrectomy Study (EVS) helped establish clinical guidelines in the treatment of post-operative endophthalmitis in a prospective, randomized, multicenter trial. The strength and limitation of the study will be discussed as well as the current knowledge of the pharmacokinetics of intravitreous injection of antibiotics. Additionally, the common pathologic organisms, the use of antibiotic therapy, steroids, and vitrectomy will be discussed.
authors.affiliation: Massachusetts Eye and Ear Infirmary and the Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Wang
authors.forename: Peter L
authors.initials: PL
authors.lastname: Lou
authors.forename: Edward A
authors.initials: EA
authors.lastname: Ryan
authors.forename: Arnold J
authors.initials: AJ
authors.lastname: Kroll
mesh_terms: D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D002387:Cataract Extraction / Q000009:adverse effects; D009877:Endophthalmitis / Q000188:drug therapy* / Q000382:microbiology; D015818:Eye Infections, Bacterial / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D011183:Postoperative Complications / Q000188:drug therapy* / Q000382:microbiology; D017410:Practice Guidelines as Topic
chemical_list: D000900:Anti-Bacterial Agents