title: Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice.
abstract: Wnts have key roles in many developmental processes, including hair follicle growth and differentiation. Stabilization of beta-catenin is essential in the canonical Wnt signaling pathway. We developed transgenic mice expressing a regulated form of beta-catenin in the skin. Chronic activation of beta-catenin in resting (telogen) hair follicles resulted in changes consistent with induction of an exaggerated, aberrant growth phase (anagen). Transient activation of beta-catenin produced a normal anagen. Our data lend strong support to the notion that a Wnt/beta-catenin signal operating on hair follicle precursor cells serves as a crucial proximal signal for the telogen-anagen transition.
authors.affiliation: Departments of Human Genetics, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA.
authors.forename: David
authors.initials: D
authors.lastname: Van Mater
authors.forename: Frank T
authors.initials: FT
authors.lastname: Kolligs
authors.forename: Andrzej A
authors.initials: AA
authors.lastname: Dlugosz
authors.forename: Eric R
authors.initials: ER
authors.lastname: Fearon
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism*; D004848:Epithelium / Q000254:growth & development / Q000502:physiology; D006197:Hair / Q000254:growth & development*; D018859:Hair Follicle / Q000254:growth & development / Q000502:physiology; D015603:Keratinocytes / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D051176:beta Catenin
chemical_list: C495267:CTNNB1 protein, mouse; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051176:beta Catenin