title: Efficacy of radiation therapy in the local control of desmoplastic malignant melanoma.
abstract: BACKGROUND
  Desmoplastic malignant melanoma (DMM) is a rare variant of malignant melanoma with high local recurrence rate after surgical excision. We performed a retrospective review to address the role of radiation therapy in local control of this tumor.
  
  
  METHODS
  Between 1976 and 1997, 44 patients with the pathologic diagnosis of DMM were registered at our tumor registry. Fourteen patients received postoperative RT, and one patient received preoperative RT. Three of the irradiated lesions had gross residual or positive surgical margins. Doses ranged from 44 to 66 Gy.
  
  
  RESULTS
  Sixty-eight percent of DMM lesions occurred in the head and neck region. Forty-eight percent (21 of 44) of patients experienced a local recurrence after initial excision (mean time to recurrence, 12 months). Local failure in head and neck was 46% (14 of 30). Clark level, primary site, and neurotropism did not predict local recurrence; the Clark level predicted distant metastasis. No viable tumor was found in the surgical specimen of the patient who received preoperative RT. None of 15 patients who received adjuvant irradiation had any additional recurrences (mean follow-up, 64.7 months). By contrast, four of seven patients with history of recurrence who did not receive RT had local relapse (p =.005). The incidence of distant metastasis did not reach statistical significance between the irradiated and nonirradiated groups.
  
  
  CONCLUSIONS
  The high rate of local recurrence of DMM after surgical resection is dramatically reduced by adjuvant radiation therapy. We recommend adjuvant postoperative radiation therapy as a part of treatment of DMM.
authors.affiliation: Department of Radiation Oncology, University of California, 200 UCLA Medical Plaza, Suite B265, Los Angeles, California 90024, USA. vongtama@radonc.ucla.edu
authors.forename: Roy
authors.initials: R
authors.lastname: Vongtama
authors.forename: Afshin
authors.initials: A
authors.lastname: Safa
authors.forename: David
authors.initials: D
authors.lastname: Gallardo
authors.forename: Thomas
authors.initials: T
authors.lastname: Calcaterra
authors.forename: Guy
authors.initials: G
authors.lastname: Juillard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000517:prevention & control*; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000532:radiotherapy / Q000601:surgery; D009420:Nervous System / Q000473:pathology; D011182:Postoperative Care; D011300:Preoperative Care; D011829:Radiation Dosage; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis