Removal of cholesteryl esters from diet-induced atherosclerotic lesions in two long-term studies in rhesus monkeys.
In two long-term studies of dietary-cholesterol-induced atherosclerosis lesions in rhesus monkeys, we determined the fatty acid composition of cholesteryl esters in the arterial intima-media preparations. In the first study (2-year study) monkeys were fed an atherogenic diet for 2 years; in the second study, (5-year study), monkeys were fed the atherogenic diet for about 5.4 years. Dietary cholesterol was removed from regressed animals and the regression periods in the 2-year study were 30 and 52 weeks and in the 5-year study were 20, 30, 52, 101, and 191 weeks. In both studies in thoracic and abdominal aortic segments, the percent removal of 18:2 cholesteryl ester (CE) was small, whereas percent removal of 18:1 CE and other CEs was much higher. We postulate that 18:2 CE is not hydrolyzed to the extent comparable to 18:1 and other CEs in lesions. Perhaps 18:2 CE is not a preferred substrate for arterial neutral cholesterol ester hydrolase.
Bhattacharyya
Ashim K
AK
Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA. abhatt@lsuhsc.edu
Strong
Jack P
JP
D000818:Animals; D001012:Aorta, Abdominal / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D001013:Aorta, Thoracic / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D002788:Cholesterol Esters / Q000032:analysis / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000378:metabolism*; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D008253:Macaca mulatta; D008297:Male
D002788:Cholesterol Esters; D002791:Cholesterol, Dietary