[Effect of zishuijianghuoyin on expression of lymphocyte AngII receptor (AT-1) mRNA of experimental hypertension rats].
OBJECTIVE
To explore the immuno-neurologic regulation of hypertension and its inherent law as well as the mechanisms of curing and systemic regulating effect of ZiShuiJiangHuoYin(ZSJHY).


METHODS
To detect expression level of AT-1mRNA in two-kidney-one-clamp renal hypertension rat lymphocyte cell by means of RT-PCR.


RESULTS
The level of AT-1 mRNA in lymphocyte was higher in group of 2K1C-RHR than that in normal group. ZSJHY (20 g/kg, 40 g/kg) had regulating effect on this.


CONCLUSIONS
Depressing excessive expression of lymphocyte AT-1 mRNA may be one of the mechanisms where ZSJHY exert immunoregulation action.
Liao
Sheng-bao
SB
Anhui College of Traditional Chinese Medicine, Hefei 230038, Anhui, China.
Ding
Rong-guang
RG
Ding
Li-li
LL
Liu
Guang-wei
GW
D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D006978:Hypertension, Renovascular / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D011945:Receptors, Angiotensin / Q000096:biosynthesis* / Q000235:genetics
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; D011945:Receptors, Angiotensin