title: Working heart function in diabetes is not improved by spironolactone treatment.
abstract: Aldosterone antagonism has emerged as an important strategy for end-stage congestive heart failure. To evaluate the potential contribution of aldosterone towards the cardiac complications of diabetes, this study examined the effects of chronic aldosterone receptor blockade (with spironolactone) on isolated working heart function in streptozotocin (STZ) - induced diabetic rats. Wistar rats were divided into four groups: control, control spironolactone-treated, diabetic, and diabetic spironolactone-treated. Following chronic spironolactone treatment (8 weeks), cardiac function was assessed in terms of the rate of contraction (+dP/dT), rate of relaxation (-dP/dT), and left ventricular developed pressure (LVDP). Untreated diabetic rats exhibited marked cardiac dysfunction when compared with age matched controls (p < 0.001). Long-term spironolactone treatment did not improve these parameters. These data demonstrate the lack of beneficial effects of aldosterone receptor blockade on isolated working heart function in diabetes.
authors.affiliation: Division of Cardiac Surgery, University of Toronto, Toronto, ON M5G 2C4, Canada.
authors.forename: Subodh
authors.initials: S
authors.lastname: Verma
authors.forename: Violet G
authors.initials: VG
authors.lastname: Yuen
authors.forename: Mitesh
authors.initials: M
authors.lastname: Badiwala
authors.forename: Todd J
authors.initials: TJ
authors.lastname: Anderson
authors.forename: John H
authors.initials: JH
authors.lastname: McNeill
mesh_terms: D000818:Animals; D016279:Atrial Function, Left / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000503:physiopathology; D003971:Diastole / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013148:Spironolactone / Q000494:pharmacology* / Q000627:therapeutic use; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone