Excessive daytime sleepiness and levodopa in Parkinson's disease: polygraphic, placebo-controlled monitoring.
The authors performed 72-hour polysomnography, including a levodopa-placebo-controlled choice reaction time test with continuous monitoring of cardiovascular variables in two patients with Parkinson's disease complaining of excessive daytime sleepiness on levodopa monotherapy. The subacute levodopa challenge was accompanied by physiologic sleep episodes, worsened reaction times, and a reduction in mean blood pressure and heart rate over baseline values, linked temporally to the sleep episodes.
Contin
Manuela
M
Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy. contin@neuro.unibo.it
Provini
Federica
F
Martinelli
Paolo
P
Riva
Roberto
R
Albani
Fiorenzo
F
Vetrugno
Roberto
R
Lombardi
Caterina
C
Montagna
Pasquale
P
Baruzzi
Agostino
A
D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D006970:Disorders of Excessive Somnolence / Q000139:chemically induced*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy*; D017286:Polysomnography; D011930:Reaction Time / Q000187:drug effects; D012890:Sleep / Q000187:drug effects
D000978:Antiparkinson Agents; D007980:Levodopa