title: Regional thrombolytic therapy and stent implantation in an acutely occluded aortobifemoral bypass graft.
abstract: OBJECTIVE
  To present a case highlighting the efficacy of local thrombolysis followed by stent implantation in acute occlusion of an aortobifemoral bypass graft.
  
  
  METHODS
  A 47-year-old man was referred to our catheterization laboratory for acute bilateral limb ischemia occurring 18 hours after an aortobifemoral bypass procedure. Angiography documented total occlusion due to massive thrombosis of the grafts. After 24 hours of local thrombolysis, repeat angiography showed complete lysis of the thrombus and an intimal flap in the abdominal aorta. A Palmaz stent was successfully implanted to cover the flap and restore adequate flow. At 1 year, the patient remains asymptomatic, and angiography showed patency of both the stent and the grafts.
  
  
  CONCLUSIONS
  Based on this patient's response, local thrombolysis followed by stenting may be a safe and effective alternative to reoperation for the treatment of acute graft thrombosis caused by an intimal aortic flap. More experience with this approach is necessary to determine if this is an acceptable and effective mode of treatment.
authors.affiliation: Division of Cardiology, San Raffaele Hospital, Milan, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Anzuini
authors.forename: Roberto
authors.initials: R
authors.lastname: Chiesa
authors.forename: Flavio
authors.initials: F
authors.lastname: Airoldi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Gimelli
authors.forename: Efrem
authors.initials: E
authors.lastname: Civilini
authors.forename: Laura
authors.initials: L
authors.lastname: Dordoni
authors.forename: Silla
authors.initials: S
authors.lastname: Frigerio
authors.forename: Marcelo R L
authors.initials: MR
authors.lastname: Moura
authors.forename: Yochai
authors.initials: Y
authors.lastname: Birnbaun
authors.forename: Antonio
authors.initials: A
authors.lastname: Colombo
authors.forename: Alberto
authors.initials: A
authors.lastname: Margonato
authors.forename: Carlo
authors.initials: C
authors.lastname: Briguori
mesh_terms: D000208:Acute Disease; D000792:Angiography; D001012:Aorta, Abdominal; D003131:Combined Modality Therapy; D005263:Femoral Artery; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015607:Stents; D015912:Thrombolytic Therapy