title: The Seiji memorial lecture: the melanosome: an ideal model to study cellular differentiation.
abstract: Melanosomes provide an intriguing model for study at many levels. In part this is due to their unique structure and function, but also in part to their involvement in pigmentary diseases and as a model to study basic cellular mechanisms of organelle biogenesis. Recent studies have elucidated the full proteome of the melanosome and the metabolic and molecular lesions involved in a number of pigmentary diseases have been resolved. This paper summarizes recent advances in the field in these areas.
authors.affiliation: Pigment Cell Biology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Tsuneto
authors.initials: T
authors.lastname: Kushimoto
authors.forename: Julio C
authors.initials: JC
authors.lastname: Valencia
authors.forename: Gertrude-E
authors.initials: GE
authors.lastname: Costin
authors.forename: Kazutomo
authors.initials: K
authors.lastname: Toyofuku
authors.forename: Hidenori
authors.initials: H
authors.lastname: Watabe
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Yasumoto
authors.forename: Francois
authors.initials: F
authors.lastname: Rouzaud
authors.forename: Wilfred D
authors.initials: WD
authors.lastname: Vieira
authors.forename: Vincent J
authors.initials: VJ
authors.lastname: Hearing
mesh_terms: D000818:Animals; D015153:Blotting, Western; D002454:Cell Differentiation; D006801:Humans; D008543:Melanins / Q000737:chemistry; D008544:Melanocytes / Q000166:cytology; D020460:Melanosomes / Q000378:metabolism* / Q000502:physiology*; D018613:Microscopy, Confocal; D008954:Models, Biological; D014442:Monophenol Monooxygenase / Q000378:metabolism; D015388:Organelles / Q000502:physiology*; D010858:Pigmentation; D020543:Proteome
chemical_list: D008543:Melanins; D020543:Proteome; D014442:Monophenol Monooxygenase