title: Molecular diversity of oligotrophic and neurotropic members of the black yeast genus Exophiala, with accent on E. dermatitidis.
abstract: Analysis of ITS rDNA of the black yeast Exophiala dermatitidis revealed a close phylogenetic relationship to the meristematic fungus Sarcinomyces phaeomuriformis. As most strains of S. phaeomuriformis have a yeast-like phenotype corresponding to the anamorph genus Exophiala, a new combination in Exophiala is proposed. On the basis of ITS sequence, M-13 fingerprint and SSU intron data, two main entities could be distinguished within E. dermatitidis. One of these (B) contained prevalently strains from environmental sources, while the other (A) mainly comprised strains from clinical sources. This may be due to a difference in virulence. All strains from severe brain and disseminated infections in East Asia clustered in group A. However, strains of group A caused a relatively mild fungemia in patients outside East Asia.
authors.affiliation: Centraalbureau voor Schimmelcultures, PO Box 85167, NL-3508 AD Utrecht, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Matos
authors.forename: G
authors.initials: G
authors.lastname: Haase
authors.forename: A H G
authors.initials: AH
authors.lastname: Gerrits van den Ende
authors.forename: G S
authors.initials: GS
authors.lastname: de Hoog
mesh_terms: D001927:Brain Diseases / Q000382:microbiology*; D016172:DNA Fingerprinting / Q000379:methods; D004271:DNA, Fungal / Q000032:analysis; D021903:DNA, Ribosomal Spacer / Q000032:analysis; D004783:Environmental Microbiology; D005093:Exophiala / Q000145:classification* / Q000235:genetics* / Q000472:pathogenicity; D005260:Female; D016469:Fungemia / Q000382:microbiology; D014644:Genetic Variation; D006801:Humans; D007438:Introns / Q000235:genetics; D016533:Mycological Typing Techniques; D009181:Mycoses / Q000382:microbiology*
chemical_list: D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer