[Effects of aqueous extract in herba of Lysimachia christinae on hyperuricemia in mice].
OBJECTIVE
To study hypouricemic effect of aqueous extract of Lysimachia christinae on hyperuricemia in mice.


METHODS
The uricase inhibitor potassium oxonate was used to induce hyperuricemia in mice, and serum uric acid level was determined with the phosphotungstic acid method.


RESULTS
The aqueous extract of Lysimachia christinae, when administered orally to the oxonate-induced hyperuricemic mice at the doses of 5.2, 10.4 and 20.8 g.kg-1, was able to elicit dose-dependent hypouricemic effects. At these doses of the extract, the serum urate levels of the oxonate-pretreated mice showed no difference from the normal mice. In normal mice, however, oral administration of the extract at the same doses did not produce any observable hypouricemic effects.


CONCLUSIONS
The aqueous extract of Lysimachia christinae possesses potent hypuricemic effects on models of hyperuricemia in mice pretreated with oxonate.
Wang
Hai-dong
HD
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, Jiangsu, China.
Ge
Fei
F
Guo
Yu-song
YS
Kong
Ling-dong
LD
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D033461:Hyperuricemia / Q000097:blood*; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D029623:Primulaceae / Q000737:chemistry*; D014527:Uric Acid / Q000097:blood*
D004365:Drugs, Chinese Herbal; D014527:Uric Acid