Percutaneous treatment of long bone nonunions: the use of autologous bone marrow and allograft bone matrix.
Sixty-six patients with 69 "stiff" nonunions (no gross motion) of long bones were entered into a prospective study. The only therapeutic intervention was the percutaneous administration of a mixture of autologous bone marrow and allograft demineralized bone matrix on an outpatient basis. Sixty-one of the percutaneous treatments (88%) resulted in union at an average of 8.1 months (range: 2 months to 3 years). This method of treating nonunions is as successful as standard iliac crest autologous bone grafting and offers the distinct advantages of decreased morbidity, reduced costs, and shorter hospital stay.
Wilkins
Ross M
RM
Denver Orthopedic Specialists, PC, Institute for Limb Preservation, Denver, Colo, USA.
Chimenti
Brian T
BT
Rifkin
Robert M
RM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016026:Bone Marrow Transplantation; D001857:Bone Matrix / Q000637:transplantation*; D005260:Female; D005599:Fractures, Ununited / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D011859:Radiography; D014184:Transplantation, Homologous; D016896:Treatment Outcome