The Seiji memorial lecture: the melanosome: an ideal model to study cellular differentiation.
Melanosomes provide an intriguing model for study at many levels. In part this is due to their unique structure and function, but also in part to their involvement in pigmentary diseases and as a model to study basic cellular mechanisms of organelle biogenesis. Recent studies have elucidated the full proteome of the melanosome and the metabolic and molecular lesions involved in a number of pigmentary diseases have been resolved. This paper summarizes recent advances in the field in these areas.
Kushimoto
Tsuneto
T
Pigment Cell Biology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Valencia
Julio C
JC
Costin
Gertrude-E
GE
Toyofuku
Kazutomo
K
Watabe
Hidenori
H
Yasumoto
Ken-Ichi
K
Rouzaud
Francois
F
Vieira
Wilfred D
WD
Hearing
Vincent J
VJ
D000818:Animals; D015153:Blotting, Western; D002454:Cell Differentiation; D006801:Humans; D008543:Melanins / Q000737:chemistry; D008544:Melanocytes / Q000166:cytology; D020460:Melanosomes / Q000378:metabolism* / Q000502:physiology*; D018613:Microscopy, Confocal; D008954:Models, Biological; D014442:Monophenol Monooxygenase / Q000378:metabolism; D015388:Organelles / Q000502:physiology*; D010858:Pigmentation; D020543:Proteome
D008543:Melanins; D020543:Proteome; D014442:Monophenol Monooxygenase