[Effects of fermented Cordyceps powder on pulmonary function in sensitized guinea pigs and airway inflammation in sensitized rats].
OBJECTIVE
To study Cordyceps (artificial fermented Cordyceps sinensis(Berk.) Sacc) powderin the treatment of asthma in the animal models.


METHODS
Pulmonary function and airway inflammation in vivo were investigated.


RESULTS
Cordyceps, 5g.kg-1(ig), significantly inhibited bronchial challenge of ovalbumin-induced change of RL and Cdyn (P < 0.05) and inhibited antigen-induced increase of eosinophils in the BALF of rats (P < 0.05).


CONCLUSIONS
The results suggested cordyceps could be applied for the prevention and cure of asthma.
Lin
X X
XX
Zhejiang Respiratory Drugs Research Laboratory of State Drugs Administration of China, Zhejiang University College of Medicine, Hangzhou 310031, Zhejiang, China.
Xie
Q M
QM
Shen
W H
WH
Chen
Y
Y
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D032661:Cordyceps / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D007915:Lepidoptera / Q000737:chemistry; D008168:Lung / Q000503:physiopathology*; D008170:Lung Compliance / Q000187:drug effects; D008297:Male; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal