title: Keratitis due to Histoplasma spp. in a horse.
abstract: A 5-year-old Holsteiner gelding from Germany was presented 2 months after a whitish discoloration of the left cornea was observed. Cytologic examination revealed intra- and extracellular globular structures, up to 4 micro m in size, consisting of a central spherical deeply basophilic body surrounded by an unstained halo. The structures were morphologically consistent with Histoplasma spp. Infection with Histoplasma organisms is not endemic in Europe. Topical use of fluconazole was successful in eliminating Histoplasma organisms within 10 days of initiation of treatment.
authors.affiliation: Department of Small Animals, Ophthalmology Service, University of Zurich, Winterthurerstrasse 260, Switzerland. mrichter@vetclinics.unizh.ch
authors.forename: Marianne
authors.initials: M
authors.lastname: Richter
authors.forename: Beat
authors.initials: B
authors.lastname: Hauser
authors.forename: Simone
authors.initials: S
authors.lastname: Kaps
authors.forename: Bernhard M
authors.initials: BM
authors.lastname: Spiess
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D015725:Fluconazole / Q000627:therapeutic use; D006658:Histoplasma / Q000145:classification / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000175:diagnosis / Q000662:veterinary*; D006734:Horse Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D006736:Horses; D007634:Keratitis / Q000175:diagnosis / Q000662:veterinary*; D008297:Male
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole