title: Environmental risk factors and work-related lower respiratory symptoms in 80 office buildings: an exploratory analysis of NIOSH data.
abstract: BACKGROUND
  We evaluated relationships between lower respiratory symptoms and risk factors for microbiological contamination in office buildings.
  
  
  METHODS
  The National Institute for Occupational Safety and Health collected data from 80 office buildings during standardized indoor environmental health hazard evaluations. Present analyses included lower respiratory symptom-based outcome definitions and risk factors for potential microbiologic contamination. Multivariate logistic regression models for selected outcomes identified key risk factors.
  
  
  RESULTS
  Adjusted odds ratios (95% confidence intervals) for "at least three of four work-related lower respiratory symptoms" were, for debris in ventilation air intake, 2.0 (1.0-3.9), and for poor drainage in air-conditioning drip pans, 2.6 (1.3-5.2). Adjusted associations with risk factors were consistently stronger for outcomes requiring both multiple symptoms and improvement away from work, and somewhat stronger among diagnosed asthmatics.
  
  
  CONCLUSIONS
  Moisture and debris in ventilation systems, possibly by supporting microbiologic growth, may increase adverse respiratory effects, particularly among asthmatics. Data from more representative buildings are needed to confirm these findings.
authors.affiliation: Indoor Environment Department, Environmental Energy Technologies Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. mjmendell@lbl.gov
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Mendell
authors.forename: Gina M
authors.initials: GM
authors.lastname: Naco
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Wilcox
authors.forename: W Karl
authors.initials: WK
authors.lastname: Sieber
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects*; D001249:Asthma / Q000150:complications* / Q000175:diagnosis; D004784:Environmental Monitoring; D006801:Humans; D016015:Logistic Models; D015999:Multivariate Analysis; D009314:National Institute for Occupational Safety and Health, U.S.; D012140:Respiratory Tract Diseases / Q000209:etiology*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014481:United States; D017132:Workplace