title: Post-operative progress of dystonia patients following globus pallidus internus deep brain stimulation.
abstract: In the current era of functional surgery for movement disorders, deep brain stimulation (DBS) of the globus pallidus internus (GPi) is emerging as the favoured intervention for patients with dystonia. Here we report our results in 20 patients with medically intractable dystonia treated with GPi stimulation. The series comprised 14 patients with generalized dystonia and six with spasmodic torticollis. Although comparisons were limited by differences in their respective neurological rating scales, chronic DBS clearly benefited both patient groups. Data conveying the rate of change in neurological function following intervention are also presented, demonstrating the gradual but progressive and sustained nature of improvement following stimulation of the GPi in dystonic patients.
authors.affiliation: The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, UK.
authors.forename: J
authors.initials: J
authors.lastname: Yianni
authors.forename: P G
authors.initials: PG
authors.lastname: Bain
authors.forename: R P
authors.initials: RP
authors.lastname: Gregory
authors.forename: D
authors.initials: D
authors.lastname: Nandi
authors.forename: C
authors.initials: C
authors.lastname: Joint
authors.forename: R B
authors.initials: RB
authors.lastname: Scott
authors.forename: J F
authors.initials: JF
authors.lastname: Stein
authors.forename: T Z
authors.initials: TZ
authors.lastname: Aziz
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D002908:Chronic Disease; D004185:Disability Evaluation; D004421:Dystonia / Q000601:surgery*; D004599:Electric Stimulation Therapy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D019635:Neurosurgical Procedures / Q000379:methods; D011182:Postoperative Care; D012043:Regression, Psychology; D012720:Severity of Illness Index; D013997:Time Factors; D014103:Torticollis / Q000601:surgery*; D016896:Treatment Outcome