title: H1oo: a pre-embryonic H1 linker histone in search of a function.
abstract: The mouse oocyte-specific linker histone H1oo (1) constitutes a novel mammalian homologue of the oocyte-specific linker histone B4 of the frog and of the cs-H1 linker histone of the sea urchin; (2) is expressed as early as the germinal vesicle (PI) stage oocyte, persisting into the MII stage oocyte, the oocytic polar bodies, and the 2-cell embryo, extinction becoming apparent at the 4-8 cell embryonic stage; and (3) may play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure.
authors.affiliation: Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Utah Health Science Center, Salt Lake City, UT 84132, USA.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tanaka
authors.forename: Maki
authors.initials: M
authors.lastname: Kihara
authors.forename: Blazej
authors.initials: B
authors.lastname: Meczekalski
authors.forename: Gretchen J
authors.initials: GJ
authors.lastname: King
authors.forename: Eli Y
authors.initials: EY
authors.lastname: Adashi
mesh_terms: D000818:Animals; D018076:DNA, Complementary / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000235:genetics* / Q000502:physiology*; D005260:Female; D006657:Histones / Q000378:metabolism; D051379:Mice; D009865:Oocytes / Q000378:metabolism; D009866:Oogenesis / Q000235:genetics* / Q000502:physiology*; D011247:Pregnancy; D011506:Proteins / Q000235:genetics* / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D018076:DNA, Complementary; C423383:H1f8 protein, mouse; D006657:Histones; D011506:Proteins; D012333:RNA, Messenger