[Calcitonin gene-related peptide changes in efferent vestibular system during vestibular compensation].
OBJECTIVE
To investigate the calcitonin gene-related peptide (CGRP) effect on efferent vestibular system during pathological state of vestibular afferent system.


METHODS
An animal model of vestibular compensation was made by administration of streptomycin to rat vestibular organ to destroy unilateral vestibular function. Change of CGRP in efferent vestibular neurons in all processes from vestibular disorder to vestibular compensation was observed utilizing ABC method of immunohistochemical technique.


RESULTS
Efferent vestibular neurons of normal animals showed low immunoreactivity to CGRP. The number of CGRP immunoreactivity neurons and level of CGRP immunoreactivity increased in efferent vestibular system during vestibular disorder, and these changes decreased with vestibular compensation.


CONCLUSIONS
Activity of CGRP in efferent vestibular system plays a regular role on accelerating vestibular compensation.
Chi
F
F
Hearing Laboratory of Ministry of Hygiene, Eye Ear Nose & Throat Hospital of Shanghai Medical University, Shanghai 200031.
Wang
Z
Z
Li
K
K
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism* / Q000502:physiology; D004195:Disease Models, Animal; D008297:Male; D009476:Neurons, Efferent / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014725:Vestibular Nerve / Q000166:cytology / Q000378:metabolism*; D014722:Vestibule, Labyrinth / Q000293:injuries* / Q000473:pathology
D015740:Calcitonin Gene-Related Peptide