The building block approach to unusual alpha-amino acid derivatives and peptides.
The building block approach was identified as a useful alternative to the commonly used Bücherer-Berg method for the preparation of cyclic unusual alpha-amino acid derivatives. The symmetrical building blocks were prepared by dialkylation of ethyl isocyanoacetate under solid-liquid phase transfer catalysis conditions while the unsymmetrical building blocks were prepared by a stepwise alkylation of the O'Donnell Schiff base. Metathesis reactions, Suzuki couplings, and cycloaddition reactions were utilized to assemble the building blocks.
Kotha
Sambasivarao
S
Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai-400 076, India. srk@chem.iitb.ac.in
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
D000596:Amino Acids; D010455:Peptides