Effect of suplatast tosilate, an antiallergic selective Th2 cytokine inhibitor, on acute eosinophilic myocarditis: a case report.
We encountered a 44-year-old woman with acute eosinophilic myocarditis that showed positive immunostaining for interleukin-4 in the area of marked infiltration of eosinophils into the myocardium. When prednisolone alone proved ineffective, supplementary treatment with suplatast tosilate, an antiallergic selective Th2 cytokine inhibitor, improved the patient's inflammation, reduced the level of cardiac enzymes, and allowed for a reduction in corticosteroid dosage without any adverse effects.
Umemoto
Seiji
S
Pharmaceutical Clinical Research Center, Yamaguchi University Hospital, 1-1-1 Minami Kogushi, Ube, Japan. umemoto@yamaguchi-u.ac.jp
Itagaki
Kazuo
K
Kimura
Masahiro
M
Itoh
Shinichi
S
Tanaka
Masakazu
M
Haraguchi
Masahiko
M
Matsuzaki
Masunori
M
D000208:Acute Disease; D000328:Adult; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001190:Arylsulfonates / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004804:Eosinophils / Q000187:drug effects*; D005260:Female; D006801:Humans; D015847:Interleukin-4 / Q000037:antagonists & inhibitors*; D009205:Myocarditis / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage; D013452:Sulfonium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology*; D013997:Time Factors
D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D001190:Arylsulfonates; D013452:Sulfonium Compounds; D015847:Interleukin-4; D011239:Prednisolone; C073028:suplatast tosilate