[Proteins regulating neurotransmitter release of synaptic vesicles at nerve terminals].
Neurotransmitter release of synaptic vesicle at nerve terminals is a complicated and elaborately regulated process, involving a cascade of protein-protein interactions. The SNARE core complex consisting of synaptobrevin/VAMP (a synaptic-terminal protein), syntaxin and SNAP-25 (synaptic membrane-associated proteins), acts as the membrane fusion machinery and plays essential roles in synaptic vesicle exocytosis. This review will discuss proteins with potential roles in synaptic vesicle exocytosis by regulating assembly, disassembly and the function of SNARE complex, and sum up the molecular model of vesicle exocytosis.
Cai
Qian
Q
Department of Neurobiology, Shanghai Second Medical University, Shanghai 200025.
Lu
Pei-Hua
PH
Sheng
Zu-Hang
ZH
D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology*; D008958:Models, Molecular; D052066:N-Ethylmaleimide-Sensitive Proteins; D009411:Nerve Endings / Q000166:cytology / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D050600:SNARE Proteins; D013572:Synaptic Vesicles / Q000502:physiology*; D050825:Synaptosomal-Associated Protein 25; D033921:Vesicular Transport Proteins
D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; C118519:SNAPIN protein, human; D050600:SNARE Proteins; D050825:Synaptosomal-Associated Protein 25; D033921:Vesicular Transport Proteins; D052066:N-Ethylmaleimide-Sensitive Proteins