Tetrabenazine in the treatment of severe pediatric chorea.
Tetrabenazine (TBZ) is widely used to treat adults with hyperkinetic movement disorders; however, published experience with the drug in pediatric patients is limited. We report on 5 children with severe chorea who were treated with TBZ. TBZ effectively controlled chorea in 4 patients, and despite the need for relatively high doses, it was well tolerated.
Chatterjee
Anjan
A
Department of Neurology, Columbia-Presbyterian Medical Center, New York, New York, USA.
Frucht
Steven J
SJ
D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D002819:Chorea / Q000188:drug therapy* / Q000209:etiology; D004314:Down Syndrome / Q000150:complications; D004660:Encephalitis / Q000150:complications; D006801:Humans; D007223:Infant; D008297:Male; D013036:Spasms, Infantile / Q000150:complications; D013747:Tetrabenazine / Q000627:therapeutic use*; D016896:Treatment Outcome
D018726:Anti-Dyskinesia Agents; D013747:Tetrabenazine