title: [Expression and significance of clusterin in normal prostate, benign prostate hyperplasia and prostate cancer].
abstract: OBJECTIVE
  To investigate the expression and significance of Clusterin in normal prostate, benign prostate hyperplasia (BPH) and prostate cancer.
  
  
  METHODS
  Clusterin expression in samples of 12 normal prostate, 15 BPH, and 56 prostate cancer were studied by immunohistochemical stain.
  
  
  RESULTS
  Of 83 cases, 67 are positive or weak positive (81%). The rate of positive or weak positive for normal prostate, BPH and prostate cancer was 17% (2/12), 73% (11/15), and 96% (54/56) respectively. The expression level of Clusterin in prostate cancer was much higher than in normal prostate (t = 8.82, P < 0.01). BPH (t = 7.63, P < 0.01) was related positively with pathological grade (r = 0.649, P < 0.01) and stage (r = 0.609, P < 0.01) of prostate cancer.
  
  
  CONCLUSIONS
  Clusterin may play an important role in the biological characteristics of prostate cancer by the anti-apoptosis pathway.
authors.affiliation: Institute of Urology, First Hospital, Peking University, Beijing 100034, China.
authors.forename: Li-qun
authors.initials: LQ
authors.lastname: Zhou
authors.forename: Xue-zhen
authors.initials: XZ
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Zeng
authors.forename: Li-li
authors.initials: LL
authors.lastname: Liang
authors.forename: Xin-yu
authors.initials: XY
authors.lastname: Yang
authors.forename: Liang
authors.initials: L
authors.lastname: Ren
authors.forename: Lee
authors.initials: L
authors.lastname: Chung
authors.forename: Zhi-wen
authors.initials: ZW
authors.lastname: Zhang
authors.forename: Yan-qun
authors.initials: YQ
authors.lastname: Na
authors.forename: Fang-liu
authors.initials: FL
authors.lastname: Gu
authors.forename: Ying-lu
authors.initials: YL
authors.lastname: Guo
mesh_terms: D017209:Apoptosis; D051152:Clusterin / Q000378:metabolism* / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology
chemical_list: D051152:Clusterin