title: [Expression and significance of serum soluble tumor necrosis factor receptor-I in patients with head and neck neoplasm].
abstract: OBJECTIVE
  To investigate the expression and significance of serum soluble tumor necrosis factor receptor-I (sTNFR-I) in patients with head and neck neoplasms.
  
  
  METHODS
  The study was undertaken to detect serum sTNFR-I levels in 160 head neck cancer patients (including 12 cases of malignant lymphoma, 62 nasopharyngeal cancer, 56 laryngeal cancer, 22 hypopharyngeal cancer, 3 maxillary cancer and 5 thyrophyma), using Sandwich enzyme-linked immuno-sorbent assay.
  
  
  RESULTS
  The sTNFR-I levels were significantly higher in patients with carcinoma than those of healthy controls (P < 0.01). The sTNFR-I levels of malignant lymphoma and nasopharyngeal carcinoma were the highest among patients with head and neck neoplasm. The correlations between the serum sTNFR-I levels and the stages of head and neck neoplasms and other laboratory parameters were also analyzed and discussed.
  
  
  CONCLUSIONS
  The serum sTNFR-I levels may reflect the human immunity function, therefore it can be used as a helpful indicator to evaluate the therapeutic effect and monitor the relapses and metastasis of cancer.
authors.affiliation: Department of Otorhinolaryngology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China. dong weida@163.com
authors.forename: W
authors.initials: W
authors.lastname: Dong
authors.forename: J
authors.initials: J
authors.lastname: Xu
authors.forename: Z
authors.initials: Z
authors.lastname: Qiao
authors.forename: N
authors.initials: N
authors.lastname: Wang
authors.forename: R
authors.initials: R
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018124:Receptors, Tumor Necrosis Factor / Q000096:biosynthesis / Q000097:blood*
chemical_list: D018124:Receptors, Tumor Necrosis Factor