title: Genome-wide linkage reveals a locus for human essential (primary) hypertension on chromosome 12p.
abstract: Essential (primary) hypertension is an important risk factor for cardiovascular morbidity and mortality. Blood pressure is largely heritable; however, the genetic factors contributing to essential hypertension are mostly unknown. We examined a large Chinese kindred (n=387) and selected a subset of 94 individuals for genotyping. An additional 32 Chinese nuclear families with essential hypertension were also recruited. Genome-wide parametric linkage analysis identified a new locus for primary hypertension on chromosome 12p (parametric LOD score 3.44). This locus overlaps with the assigned locus that causes severe autosomal-dominant hypertension and brachydactyly, the only form of monogenic hypertension known to date that resembles primary hypertension. We suggest that this genomic region, spanning 18 annotated genes, will be of great relevance in elucidating new mechanisms for primary hypertension.
authors.affiliation: Cardiovascular Institute, Sino-German Laboratory, FuWai Hospital, Beijing, People's Republic of China.
authors.forename: Maolian
authors.initials: M
authors.lastname: Gong
authors.forename: Hongye
authors.initials: H
authors.lastname: Zhang
authors.forename: Herbert
authors.initials: H
authors.lastname: Schulz
authors.forename: Young-Ae
authors.initials: YA
authors.lastname: Lee
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.forename: Sylvia
authors.initials: S
authors.lastname: Bähring
authors.forename: Friedrich C
authors.initials: FC
authors.lastname: Luft
authors.forename: Peter
authors.initials: P
authors.lastname: Nürnberg
authors.forename: André
authors.initials: A
authors.lastname: Reis
authors.forename: Klaus
authors.initials: K
authors.lastname: Rohde
authors.forename: Detlev
authors.initials: D
authors.lastname: Ganten
authors.forename: Rutai
authors.initials: R
authors.lastname: Hui
authors.forename: Norbert
authors.initials: N
authors.lastname: Hübner
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D002881:Chromosomes, Human, Pair 12; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010375:Pedigree