Effect of a single neonatal endorphin treatment on the hormone content of adult rat white blood cells and mast cells.
Using flow cytometry and confocal microscopy, the presence of endorphin, serotonin and chorionic gonadotropin (hCG) was demonstrated in rat white blood cells and peritoneal mast cells. After a single neonatal treatment with beta-endorphin (hormonal imprinting), the mast cells of female rats reaching adulthood contained significantly less endorphin and serotonin, as well as slightly less hCG, than control cells. There was no change in the hormone content of the mast cells of males. The lymphocytes, monocytes and granulocytes of both sexes also contained the three hormones, but endorphin imprinting had no effect on these cells.
Csaba
György
G
Department of Genetics, Cell and Immunobiology, Semmelweis University, H-1445 Budapest, POB 370, Hungary. csagyor@dgci.sote.hu
Kovács
Péter
P
Pállinger
Eva
E
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D004723:Endorphins / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D012727:Sex Characteristics
D006063:Chorionic Gonadotropin; D004723:Endorphins; D012701:Serotonin