Association of the genetic polymorphism in cytochrome P450 (CYP) 1A1 with risk of familial prostate cancer in a Japanese population: a case-control study.
Association between genetic polymorphisms of CYP1A1 and familial prostate cancer risk was examined by a case-control study of 185 individuals. Although the individual analysis of m1 or m2 genotype of CYP1A1 showed no significant association with prostate cancer risk, the presence of any mutated alleles significantly increased prostate cancer risk in comparison with wild-type genotypes by combination analysis (odds ratio [OR]=2.38; 95% confidence interval [CI]=1.72-3.29; P=0.0069). Furthermore, metastatic cancer had a significant association with mutated alleles of m1 and m2. These finding suggested that CYP1A1 polymorphisms has an association with prostate cancer risk, especially with progression of prostate cancer.
Suzuki
Kazuhiro
K
Department of Urology, Gunma University School of Medicine, 3-39-22 Showa-machi, Maebashi-City, Japan. kazu@showa.gunma-u.ac.jp
Matsui
Hiroshi
H
Nakazato
Haruki
H
Koike
Hidekazu
H
Okugi
Hironobu
H
Hasumi
Masaru
M
Ohtake
Nobuaki
N
Nakata
Seiji
S
Takei
Tomoyuki
T
Hatori
Motoaki
M
Ito
Kazuto
K
Yamanaka
Hidetoshi
H
D000230:Adenocarcinoma / Q000201:enzymology / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D018450:Disease Progression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000453:epidemiology*; D012306:Risk
D009363:Neoplasm Proteins; D019363:Cytochrome P-450 CYP1A1