Unusual coupling reactions of aldehydes and alkynes: a novel preparation of substituted phthalic acid derivatives by automated synthesis.
Based upon a highly versatile multicomponent methodology, a new one-pot synthesis of substituted phthalic acid derivatives from alpha,beta-unsaturated aldehydes was developed. The reaction involves the intermediacy of an acetamidodiene species which undergoes Diels-Alder addition to diethyl acetylenedicarboxylate. The resultant acetamidocyclohexadiene is subject to elimination of acetamide under the reaction conditions to give rise to substituted diethyl phthalates in good yields. This domino condensation-cycloaddition-elimination sequence has been applied to a variety of alpha,beta-unsaturated aldehydes. Furthermore, we demonstrated the exploitation of parallelized and automated synthesis technology for the rapid screening of reaction conditions and compositions. Detailed studies revealed the catalytic role of the employed acetamide and the occurrence of a stereoselective 1,4-syn elimination pathway under standard conditions.
Jacobi von Wangelin
Axel
A
Leibniz-Institut für Organische Katalyse an der Universität Rostock e V, Buchbinderstrasse 5-6 18055 Rostock, Germany.
Neumann
Helfried
H
Gördes
Dirk
D
Klaus
Stefan
S
Jiao
Haijun
H
Spannenberg
Anke
A
Krüger
Thomas
T
Wendler
Christian
C
Thurow
Kerstin
K
Stoll
Norbert
N
Beller
Matthias
M