title: [Molecular mechanisms regulating transport of low molecular weight substances in the hepatocyte].
abstract: Transporters of sinusoidal and lateral membranes mediate uptake of inorganic and organic substances to hepatocyte. In hepatocyte lipophilic compounds are biotransformed (hydroxylated and conjugated) and excreted into bile and urine. Vectorial movement of solutes and water from blood to bile is maintained by pumps of ABC superfamily secreting bile salts (bile acid dependent flow) and other solutes: bilirubin, phospholipids, glutathione and inorganic salts (bile acid independent flow).
authors.affiliation: Zakład Biochemii Farmaceutycznej Akademii Medycznej w Białymstoku. kzwie@amb.edu.pl
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zwierz
authors.forename: Przemysław
authors.initials: P
authors.lastname: Wielgat
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Borzym-Kluczyk
mesh_terms: D000818:Animals; D000838:Anions / Q000378:metabolism* / Q000493:pharmacokinetics*; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D001692:Biological Transport / Q000502:physiology; D001834:Body Water / Q000378:metabolism; D022781:Hepatocytes / Q000378:metabolism*; D006801:Humans; D006900:Hydroxylation; D008970:Molecular Weight; D012964:Sodium / Q000378:metabolism; D014556:Urine
chemical_list: D000838:Anions; D001647:Bile Acids and Salts; D012964:Sodium