title: Isolation of homodolastatin 16, a new cyclic depsipeptide from a Kenyan collection of Lyngbya majuscula.
abstract: An examination of an organic extract of the cyanobacterium Lyngbya majuscula, collected from Wasini Island off the southern Kenyan coast, led to the isolation of the known cyclic depsipeptide antanapeptin A (1), recently isolated from a Madagascan collection of L. majuscula, and a new bioactive cyclic depsipeptide, homodolastatin 16 (2). The structures of these two compounds were determined from NMR and mass spectrometry data. Homodolastatin 16, a higher homologue of the potential anticancer agent dolastatin 16, exhibited moderate activity against oesophageal and cervical cancer cell lines.
authors.affiliation: Department of Chemistry, Rhodes University, Grahamstown, South Africa. M.Davies-Coleman@ru.ac.za
authors.forename: Michael T
authors.initials: MT
authors.lastname: Davies-Coleman
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Dzeha
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Gray
authors.forename: Sonja
authors.initials: S
authors.lastname: Hess
authors.forename: Lewis K
authors.initials: LK
authors.lastname: Pannell
authors.forename: Denver T
authors.initials: DT
authors.lastname: Hendricks
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Arendse
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides; D004354:Drug Screening Assays, Antitumor; D004938:Esophageal Neoplasms; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D007630:Kenya; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D002583:Uterine Cervical Neoplasms
chemical_list: D000970:Antineoplastic Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C108201:dolastatin 16; C478188:homodolastatin 16