title: Differential activation on fMRI of monozygotic twins discordant for AD.
abstract: This is the first report of fMRI in monozygotic twins discordant for AD. FMRI brain activation patterns were examined during visuospatial and verbal working memory tasks. The affected twin had greater parietal involvement bilaterally during both working memory tasks and reduced left dorsolateral prefrontal cortex activity on the visuospatial memory task. Thus, fMRI may identify additional brain regions recruited in patients with AD to perform a given cognitive task.
authors.affiliation: Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Texas 75390-9070, USA. anne.lipton@utsouthwestern.edu
authors.forename: A M
authors.initials: AM
authors.lastname: Lipton
authors.forename: R
authors.initials: R
authors.lastname: McColl
authors.forename: C M
authors.initials: CM
authors.lastname: Cullum
authors.forename: G
authors.initials: G
authors.lastname: Allen
authors.forename: W K
authors.initials: WK
authors.lastname: Ringe
authors.forename: F J
authors.initials: FJ
authors.lastname: Bonte
authors.forename: E
authors.initials: E
authors.lastname: McDonald
authors.forename: C D
authors.initials: CD
authors.lastname: Rubin
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D004200:Diseases in Twins; D006720:Homozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000235:genetics / Q000473:pathology; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D011877:Radionuclide Imaging; D016037:Single-Blind Method; D013382:Subtraction Technique; D014430:Twins, Monozygotic; D014706:Verbal Learning
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E