[Significance and detection of interleukin-8 in human nasal polyps].
OBJECTIVE
To investigate the distribution and content of immunoreaction interleukin-8(IL-8) antigen in the human nasal polyps.


METHODS
Twenty-two cases of nasal polyp and 10 cases of normal inferior turbinate were studied with immunohistochemical SABC method and ELISA method.


RESULTS
Immunohistochemical results demonstrated that IL-8 antigen staining occurred predominantly within inflammatory and epithelium cell plasm. The level of IL-8 in nasal polyp tissue was higher than in normal control specimens. The value in nasal polyp tissue was in 322.06-2091.41 pg/ml, but in normal with a range of 29.31-332.19 pg/ml. The results demonstrated a remarkable difference between the two groups (P < 0.001).


CONCLUSIONS
These data demonstrated the presence of IL-8 antigen in nasal polyps. Thus IL-8 likely plays a significant role in the pathogenesis of this disease process. There is an important significance of finding a potential treatment method.
Li
X
X
Department of Otorhinolaryngology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. LP@fimmu.edu.cn
Huang
A
A
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000276:immunology*; D014420:Turbinates / Q000737:chemistry
D016209:Interleukin-8