Shigella interaction with intestinal epithelial cells determines the innate immune response in shigellosis.
Shigellae are Gram-negative bacilli that cause bacillary dysentery in humans. This review summarizes current knowledge of Shigella pathogenesis and pathogenicity factors, invasion of epithelial cells, intracellular motility and cell-to-cell spreading, as well as components of the host cell involved in innate immune responses.
Fernandez
M Isabel
MI
Unité de Pathogénie Microbienne Moléculaire, INSERM U389, Institut Pasteur, Rue du Dr. Roux 28, F-75724 Paris 15, France.
Sansonetti
Philippe J
PJ
D000818:Animals; D004405:Dysentery, Bacillary / Q000276:immunology* / Q000382:microbiology; D004847:Epithelial Cells / Q000382:microbiology*; D006367:HeLa Cells; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation; D007413:Intestinal Mucosa / Q000382:microbiology*; D012760:Shigella / Q000276:immunology / Q000472:pathogenicity*; D014774:Virulence