Haemolymph proteins of larvae of Galleria mellonella detoxify endotoxins of the insect pathogenic bacteria Xenorhabdus nematophilus (Enterobacteriaceae).
Haemolymph of non-vaccinated Galleria mellonella larvae contains two proteins, LBP-1 (17.2kDa) and LBP-2 (26.0kDa) that:bond to the surfaces of the insect pathogenic bacteria, Xenorhabdus nematophilus;prevented lipid A-binding dye attaching to the lipid A of X. nematophilus endotoxin; andreduced endotoxin activity on the haemocytes.Protein LBP-1 also blocked the inhibition of prophenoloxidase activation by the endotoxins. It is proposed that proteins LBP-1 and LBP-2 are part of the containment responses of the insects to bacteria.
Halwani
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Department of Natural Resource Sciences, McGill University, Macdonald Campus, 21,111 Lakeshore Road, Ste Anne de Bellevue, PQ, H9X 3V9, Canada
Dunphy
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