Analysis of albendazole metabolites by electrospray LC-MS/MS as a probe to elucidate electro-oxidation mechanism of albendazole.
The electrochemical oxidation of albendazole was accomplished by controlled potential electrolysis technique. The oxidation was carried out in different pH solutions and yields the same products obtained by in vivo and in vitro metabolism, i.e. albendazole sulfoxide and albendazole sulfone. The identification of albendazole oxidation products was carried out by LC-MS/MS.
de Lima
Renata Galvão
RG
Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, USP, Av. dos Bandeirantes, 3900, 14040-901, Ribeirão Preto, São Paulo, Brazil.
Bonato
Pierina Sueli
PS
da Silva
Roberto Santana
RS
D015766:Albendazole / Q000032:analysis* / Q000378:metabolism*; D004563:Electrochemistry; D010084:Oxidation-Reduction; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
D015766:Albendazole