title: Terminoside A, a new triterpene glycoside from the bark of Terminalia arjuna inhibits nitric oxide production in murine macrophages.
abstract: Terminoside A (1), a new oleanane-type triterpene was isolated from the acetone fraction of the ethanolic extract of stem bark of Terminalia arjuna. The structure was established as olean-1alpha,3beta,22beta-triol-12-en-28-oic acid-3beta-D-glucopyranoside. On the basis of spectral data and chemical reactions, terminoside A, potently inhibited nitric oxide (NO) production and decreased inducible nitric oxide synthase (iNOS) levels in lipopolysaccharide-stimulated macrophages.
authors.affiliation: Department of Chemistry, Faculty of Science, Hamdard University, New Delhi 110 062, India.
authors.forename: Asif
authors.initials: A
authors.lastname: Ali
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Kaur
authors.forename: Hinna
authors.initials: H
authors.lastname: Hamid
authors.forename: Tarique
authors.initials: T
authors.lastname: Abdullah
authors.forename: Mohammed
authors.initials: M
authors.lastname: Ali
authors.forename: M
authors.initials: M
authors.lastname: Niwa
authors.forename: M S
authors.initials: MS
authors.lastname: Alam
mesh_terms: D000818:Animals; D002301:Cardiac Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D017550:Spectroscopy, Fourier Transform Infrared; D029766:Terminalia / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019323:omega-N-Methylarginine / Q000494:pharmacology
chemical_list: D002301:Cardiac Glycosides; D006027:Glycosides; D014315:Triterpenes; C476549:terminoside A; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse