title: Cerebrovascular diseases and depression.
abstract: Cerebrovascular diseases constitute a leading health hazard. The association between stroke and depression has been recognized for many years. Depression is the most common psychiatric disorder associated with cerebrovascular diseases, most episodes of post-stroke depression occur in the first 2 years after a cerebrovascular accident. Studies have found an association between lesion location, physical impairment, cognitive impairment, aphasia, and post-stroke depression. The location of the lesion in terms of proximity to the left frontal pole of the brain has a profound impact on the frequency and severity of post-stroke depression. Treatment modalities include pharmacotherapy, psychotherapy, electroconvulsive therapy, and rehabilitation. Understanding the psychologic and physical morbidity of post-stroke depression, as well as its timely, comprehensive treatment, are important for effective management.
authors.affiliation: Neuropsychiatry Clinic, Jaslok Hospital and Research Centre, 15 Dr B G Deshmukh Marg, Bombay 400 026, India. rajeshparikh@vsnl.com
authors.forename: Himani
authors.initials: H
authors.lastname: Ghoge
authors.forename: Santvana
authors.initials: S
authors.lastname: Sharma
authors.forename: Shamash
authors.initials: S
authors.lastname: Sonawalla
authors.forename: Rajesh
authors.initials: R
authors.lastname: Parikh
mesh_terms: D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D001921:Brain / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D003704:Dementia / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D015140:Dementia, Vascular / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000502:physiology; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D018377:Neurotransmitter Agents