title: Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. I. Taxonomy, fermentation and biological activities.
abstract: Thiazolyl peptide antibiotics, nocathiacin I, II and III, were identified in a culture of Nocardia sp. WW-12651 (ATCC 202099). They exhibit potent in vitro activity (ng/ml) against a wide spectrum of gram-positive bacteria, including multiple-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), multi-drug resistant Enterococcus faecium (MREF) and fully penicillin-resistant Streptococcus pneumoniae (PRSP), and demonstrate excellent in vivo efficacy in a systemic Staphylococcus aureus infection mice model.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA. wenying.li@bms.com
authors.forename: Wenying
authors.initials: W
authors.lastname: Li
authors.forename: John E
authors.initials: JE
authors.lastname: Leet
authors.forename: Helen A
authors.initials: HA
authors.lastname: Ax
authors.forename: Donald R
authors.initials: DR
authors.lastname: Gustavson
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Brown
authors.forename: Laura
authors.initials: L
authors.lastname: Turner
authors.forename: Kimberly
authors.initials: K
authors.lastname: Brown
authors.forename: Junius
authors.initials: J
authors.lastname: Clark
authors.forename: Hyekyung
authors.initials: H
authors.lastname: Yang
authors.forename: Joan
authors.initials: J
authors.lastname: Fung-Tomc
authors.forename: Kin S
authors.initials: KS
authors.lastname: Lam
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009615:Nocardia / Q000737:chemistry* / Q000145:classification; D010455:Peptides
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides