[CD14 (C-159-->T) polymorphism and levels of C-reactive protein].
BACKGROUND
High plasma levels of C-reactive protein (involved in unspecific host defence) have been described as independent risk factor of atherosclerosis. The possible association has been analysed between the CD14C-159-->T polymorphism and plasma level of CRP.


RESULTS
With the PCR and subsequent restriction analysis we have evaluated C-159-->T polymorphism in the CD14 gene of 166 representatively selected male Caucasians with known plasma level of CRP. The CRP was measured immunologically. A significantly higher (p < 0.01) frequency of the CD14-159TT homozygotes between the individuals with the plasma level of CRP > 2.19 mg/l (31.9%, 15 out of 47) has been detected when compared to the group with plasma level of CRP lower than 2.18 mg/l (11.9%, 5 out of 42).


CONCLUSIONS
CD14 C-159-->T polymorphism could be the first described genetic marker associated with plasma level of C-reactive protein.
Hubácek
J A
JA
Laborator pro výzkum aterosklerózy IKEM, Praha. jaroslav.hubacek@medicon.cz
Stávek
P
P
Pit'ha
J
J
Skodová
Z
Z
Poledne
R
R
D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D005787:Gene Frequency; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D018950:Lipopolysaccharide Receptors; D002097:C-Reactive Protein