[Penetrometry in evaluation of flow and structure of powdered substances].
Usability of modified penetrometry is examined and significant relationships with routinely used characteristics of flowability and structure of powdered substances are searched for in size fractions of sodium chloride, potassium chloride, sodium citrate, and potassium citrate. A systematic study of interrelationships between properties made it possible to achieve sufficiently reproducible results without a necessity of consolidation. By means of factor analysis, a connection between penetrometry, bulk flow rate, and Kawakita-constant was demonstrated. For multidimensional linear regression for estimation of penetrometry, the significance of examined properties decreases in the order Kawakita-constant > loose bulk density > total porosity > bulk flow rate > mass flow rate. The most important item of knowledge gained in the study is the dependence of penetrometry on a combination of loose bulk density and Kawakita-constant.
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Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové. zsz@faf.cuni.cz
D002951:Citrates; D010316:Particle Size; D011189:Potassium Chloride; D019357:Potassium Citrate; D011208:Powders; D012212:Rheology; D012965:Sodium Chloride; D000077559:Sodium Citrate; D013678:Technology, Pharmaceutical / Q000379:methods
D002951:Citrates; D011208:Powders; D000077559:Sodium Citrate; D012965:Sodium Chloride; D011189:Potassium Chloride; D019357:Potassium Citrate