Vascular thrombosis and acute cytomegalovirus infection in immunocompetent patients: report of 2 cases and literature review.
Acute cytomegalovirus (CMV) infection in immunocompetent patients is common worldwide, with seroprevalence rates of 40%-100%, depending on the country, socioeconomic conditions, and the patient's age. Infection is most often asymptomatic, but acute cytomegalovirus infection is occasionally revealed by prolonged fever, cervical lymphadenitis, and arthralgia, and it is more rarely revealed by pneumonia, myocarditis, pericarditis, colitis, and hemolytic anemia. Here, we report 2 cases of acute CMV infection in nonimmunocompromised adults that were complicated by venous thrombosis with pulmonary embolism. We also review previously reported cases of vascular thrombosis and discuss the propensity of CMV to induce vascular damage with associated thrombosis.
Abgueguen
Pierre
P
Department of Infectious Diseases, Centre Hospitalo-Universitaire, Angers, France. piabgueguen@chu-angers.fr
Delbos
Valérie
V
Chennebault
Jean Marie
JM
Payan
Christopher
C
Pichard
Eric
E
D000328:Adult; D000998:Antiviral Agents; D003092:Colitis / Q000209:etiology; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D007121:Immunocompetence; D011655:Pulmonary Embolism / Q000209:etiology*; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000188:drug therapy / Q000209:etiology / Q000821:virology*
D000998:Antiviral Agents; D015774:Ganciclovir