Glucocorticoids and dehydroepiandrosterone sulfate ameliorate ischemia-induced injury of the cochlea.
This study aimed to evaluate the effects of steroidal drugs on the functional recovery of the cochlea after transient ischemia. Albino guinea pigs were subjected to transient cochlear ischemia of 30 min duration, and the threshold shifts of the compound action potential (CAP) from the pre-ischemic values were evaluated 4 h after ischemia. Pre-ischemic administration of a glucocorticoid, prednisolone or methylprednisolone, significantly ameliorated the post-ischemic CAP threshold shifts as compared with control animals at a relatively wide range of doses. Post-ischemic administration of these glucocorticoids also exhibited protective effects. Pre-ischemic administration of dehydroepiandrosterone sulfate significantly decreased the post-ischemic CAP threshold shifts 4 h after ischemia. The present results indicate that glucocorticoids and dehydroepiandrosterone sulfate possess therapeutic effects against ischemic injury of the cochlea, such as idiopathic sudden sensorineural hearing loss.
Tabuchi
Keiji
K
Department of Otolaryngology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.
Oikawa
Keiko
K
Uemaetomari
Isao
I
Tsuji
Shigeki
S
Wada
Tetsuro
T
Hara
Akira
A
D000200:Action Potentials / Q000187:drug effects; D000704:Analysis of Variance; D000818:Animals; D003051:Cochlea / Q000098:blood supply* / Q000503:physiopathology*; D019314:Dehydroepiandrosterone Sulfate / Q000494:pharmacology*; D004056:Differential Threshold / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology*; D006168:Guinea Pigs; D007511:Ischemia / Q000503:physiopathology*; D008775:Methylprednisolone / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology
D005938:Glucocorticoids; D019314:Dehydroepiandrosterone Sulfate; D011239:Prednisolone; D008775:Methylprednisolone