Improvement on the auxiliary total artificial heart (ATAH) left chamber design.
The auxiliary total artificial heart (ATAH) is an electromechanically driven artificial heart with reduced dimensions, which is able to be implanted in the right thoracic or abdominal cavities of an average human patient without removing the natural heart or the heart neurohumoral inherent control mechanism for the arterial pressure. This device uses a brushless direct current motor and a mechanical actuator (roller screw) to move two diaphragms. The ATAH's beating frequency is regulated through the change of the left preload, based on Frank-Starling's law, assisting the native heart in obtaining adequate blood flow. The ATAH left and right stroke volumes are 38 ml and 34 ml, respectively, giving approximately 5 L/min of cardiac output at 160 bpm. Flow visualization studies were performed in critical areas on the ATAH left chamber. A closed circuit loop was used with water and glycerin (37%) at 25 degrees C. Amberlite particles (80 mesh) were illuminated by a 1 mm planar helium-neon laser light. With left mean preload fixed at 10 mm Hg and the afterload at 100 mm Hg, the heart rate varied from 60 to 200 bpm. Two porcine valves were used on the inlet and outlet ports. The flow pattern images were obtained using a color micro-camera and a video recorder. Subsequently, these images were digitized using a PC computer. A persistent stagnant flow was detected in the left chamber inlet port. After improvement on the left chamber design, this stagnant flow disappeared.
Andrade
Aron
A
Department of Bioengineering, Institute Dante Pazzanese of Cardiology, São Paulo, Brazil. aandrade@cte.dante.br
Fonseca
Jeison
J
Legendre
Daniel
D
Nicolosi
Denys
D
Biscegli
Jose
J
Pinotti
Marcos
M
Ohashi
Yukio
Y
Nosé
Yukihiko
Y
D000818:Animals; D001783:Blood Flow Velocity; D002302:Cardiac Output; D006354:Heart, Artificial; D006353:Heart-Assist Devices; D006801:Humans; D008904:Miniaturization; D011474:Prosthesis Design; D013552:Swine; D014741:Video Recording