The FimH A27V mutation is pathoadaptive for urovirulence in Escherichia coli B2 phylogenetic group isolates.
Correlations between FimH mutations and virulence were established by studying a collection of human commensal and extraintestinal pathogenic Escherichia coli natural isolates. Pathoadaptive (A27V and, to a lesser extent, A119V) and "commensal-adaptive" (A202V) mutations were evidenced in B2 phylogenetic group strains. fimH phylogenetic analysis indicates that these pathoadaptive mutations occurred several times.
Hommais
Florence
F
INSERM U458, Hôpital Robert Debré Centre d'Etude du Polymorphisme Humain, Hôpital Saint Louis, Paris, France.
Gouriou
Stéphanie
S
Amorin
Christine
C
Bui
Hung
H
Rahimy
Mohamed Chérif
MC
Picard
Bertrand
B
Denamur
Erick
E
D018830:Adhesins, Escherichia coli / Q000235:genetics* / Q000502:physiology; D004926:Escherichia coli / Q000145:classification / Q000472:pathogenicity*; D036781:Fimbriae Proteins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D009154:Mutation; D010802:Phylogeny; D014552:Urinary Tract Infections / Q000382:microbiology*; D014774:Virulence
D018830:Adhesins, Escherichia coli; C058769:fimH protein, E coli; D036781:Fimbriae Proteins