title: Inhibition of proliferation of a colon cancer cell line by indole-3-carbinol.
abstract: OBJECTIVE: To observe the effect of Indole-3-carbinol (I3C), a naturally occurring component of cruciferous vegetables, on cell proliferation of a colon cancer cell line. METHODS: Cell proliferation was measured using three different methods; 3H-thymidine incorporation, cell count and colourimetric assay. RESULTS: Each method of measurement revealed that I3C significantly reduced cell proliferation at concentrations of > 0.1 mM. CONCLUSION: The present study demonstrates for the first time the capacity of indole-3-carbinol to inhibit cell proliferation of a colon cancer cell line.
authors.affiliation: Discipline of Surgical Science Faculty of Medicine and Health Sciences The University of Newcastle.
authors.forename: H. R
authors.initials: HR
authors.lastname: Frydoonfar
authors.forename: D. R
authors.initials: DR
authors.lastname: McGrath
authors.forename: A. D
authors.initials: AD
authors.lastname: Spigelman