Body composition and energy expenditure: relationship and changes in obese subjects before and after biliopancreatic diversion.
Changes in total and segmental body composition were studied in 101 obese women before and 2, 6, 12, and 24 months after biliopancreatic diversion (BPD) and data 24 months after surgery were matched to 53 control subjects. The patients were studied by anthropometry, indirect calorimetry, and double-emission x-ray absorptiometry (DXA). The combination of calorimetry and body composition analysis allowed estimation of visceral and muscle lean mass. We observed a significant (analysis of variance [ANOVA]: P <.05) progressive reduction of fat and lean body mass (LBM) following BPD, with stabilization of both parameters between 12 and 24 months at levels not different from controls. Fat loss was significant in the arms, legs, and trunk segments. After 24 months, there was no significant difference in segmental fat mass between post-BPD patients and controls. Calorimetric data seem to confirm lean body mass (LBM) reduction. Visceral lean mass (kg) was significantly reduced from 8.1 +/- 2.2 in obese subjects to 6.5 +/- 1.8 in post-BPD patients at 24 months (P <.05); the control value was 7.2 +/- 1.8. Muscular lean mass (kg) was also significantly reduced, from 50.2 +/- 5.8 to 39.8 +/- 5.7 in the same subjects (P <.05), with a control value of 42.5 +/- 5.9. The decrease in muscle and visceral LBM reached control values without significant differences. Viscera/muscle ratio in pre-BPD patients was preserved in post-BPD patients at 24 months, but it was reduced during weight loss. Body composition studies showed a logarithmic relationship between fat and lean mass and a physiological contribution of lean mass to weight loss in the BPD patients. In conclusion, weight loss after BPD was achieved with an appropriate decline of LBM and with all parameters reaching, at stable weight, values similar to weight-matched controls.
Tacchino
Roberto M
RM
Institutes of Endocrinology and Clinical Surgery, Catholic University, Rome, Italy.
Mancini
Antonio
A
Perrelli
Michele
M
Bianchi
Antonio
A
Giampietro
Antonella
A
Milardi
Domenico
D
Vezzosi
Chiara
C
Sacco
Eugenia
E
De Marinis
Laura
L
D000273:Adipose Tissue / Q000502:physiology; D000293:Adolescent; D000328:Adult; D015904:Biliopancreatic Diversion; D001823:Body Composition / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D004032:Diet; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism* / Q000628:therapy*; D013997:Time Factors; D015431:Weight Loss