Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues.
Three new endocannabinoid analogues in which amide moiety was replaced either by oxomethylene group or ester moiety with simultaneous substitution of both alpha-hydrogens with methyl groups were synthesized and their abilities to interact with CB1-receptor and FAAH were investigated.
El Fangour
Siham
S
UMR CNRS 5074, Faculté de Pharmacie, 15 av. C. Flahault, BP 14491, F-34093 5, Montpellier Cedex, France. balas@pharma.univ-montpl.fr
Balas
Laurence
L
Rossi
Jean-Claude
JC
Fedenyuk
Andrey
A
Gretskaya
Natalia
N
Bobrov
Mikhail
M
Bezuglov
Vladimir
V
Hillard
Cecilia J
CJ
Durand
Thierry
T
D000581:Amidohydrolases / Q000037:antagonists & inhibitors; D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D001667:Binding, Competitive; D063385:Cannabinoid Receptor Modulators / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D063388:Endocannabinoids; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D005026:Ethylene Glycols / Q000494:pharmacology; D053284:Polyunsaturated Alkamides; D011869:Radioligand Assay; D051381:Rats; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism; D000099252:Fatty Acid Amide Hydrolases
D000581:Amidohydrolases; D001095:Arachidonic Acids; D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D004791:Enzyme Inhibitors; D005026:Ethylene Glycols; D053284:Polyunsaturated Alkamides; D043884:Receptor, Cannabinoid, CB1; D000099252:Fatty Acid Amide Hydrolases; C114008:arachidonoylethylene glycol; C078814:anandamide