title: [Specific toxic effects of 2,4,6-trinitrotoluene on Bacillus subtilis SK1].
abstract: Using Bacillus subtilis SK1 as an example, it was demonstrated for the first time that 2,4,6-trinitrotoluene (TNT) transformation pathways change with TNT concentration. The growth of cultured B. subtilis SK1, delayed at 20 mg/l TNT (minimum toxic concentration), was resumed following TNT transformation. Aromatic amines were predominant metabolites detected in the culture medium at early stages of TNT transformation. The culture growth was completely inhibited by 200 mg/l TNT. As this took place, nitrites accumulated in the culture medium.
authors.affiliation: Laboratory of Engineering Enzymology, Research Institute of Biology, Biological Faculty, Kazan State University, Kazan, 420008 Russia.
authors.forename: B M
authors.initials: BM
authors.lastname: Kurinenko
authors.forename: G Iu
authors.initials: GIu
authors.lastname: Iakovleva
authors.forename: N A
authors.initials: NA
authors.lastname: Denivarova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Abreimova
mesh_terms: D000588:Amines / Q000378:metabolism; D001412:Bacillus subtilis / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D009573:Nitrites / Q000378:metabolism; D012988:Soil Microbiology; D014303:Trinitrotoluene / Q000378:metabolism* / Q000633:toxicity*
chemical_list: D000588:Amines; D009573:Nitrites; D014303:Trinitrotoluene