title: A functionalized cobalt(III) mixed-polypyridyl complex as a newly designed DNA molecular light switch.
abstract: The ligand ODHIP (3,4-dihydroxyl-imidazo[4,5-f][1,10]phenanthroline) and its cobalt(III) complex [Co(bpy)(2)(ODHIP)](3+) were synthesized and characterized. Binding of this complex with calf thymus DNA has been investigated by spectroscopic methods and viscosity. The experimental results indicated that the complex bound to DNA by intercalation. In Tris buffer, the complex could emit relatively weak luminescence. After binding to DNA, the notable enhancement was observed. However, when the Cu(2+) was further added, the luminescence decreased gradually and disappeared after the equimolar concentrations of Cu(2+) was added, which exhibited the "off-on-off" properties of molecular light switch.
authors.affiliation: Department of Chemistry and Biology, Normal College, Shenzhen University, Shenzhen 518060, China. qlzh98@yahoo.com.cn
authors.forename: Qian-Ling
authors.initials: QL
authors.lastname: Zhang
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Liu
authors.forename: Xiang-Zhong
authors.initials: XZ
authors.lastname: Ren
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Liu
authors.forename: Liang-Nian
authors.initials: LN
authors.lastname: Ji
mesh_terms: D000818:Animals; D002417:Cattle; D003035:Cobalt / Q000737:chemistry*; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D008163:Luminescent Measurements; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010618:Phenanthrolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D014783:Viscosity
chemical_list: D007364:Intercalating Agents; D008024:Ligands; D009942:Organometallic Compounds; D010618:Phenanthrolines; D003035:Cobalt; D003300:Copper; D004247:DNA; C427203:calf thymus DNA