title: [Effects of the active components of some Chinese herbs on drug metabolizing-enzymes].
abstract: OBJECTIVE
  To review the effects of the active components of Chinese herbs on drug metabolizing-enzymes.
  
  
  METHODS
  Relevant research papers reported in recent years were consulted and studied.
  
  
  RESULTS
  The drug metabolizing-enzymes cytochrome P450 and UDP-glucuronosyl transferase and glutathione S-transferase were inhibited or induced by the flavonoids, furocoumarins, and the active components extracted from salvia miltiorrhiza and hypericum perforatum, and so on, which therefore slowed or sped metabolism of other drugs in vivo and in vitro.
  
  
  CONCLUSIONS
  Much attention should be paid to the metabolic interaction of the Chinese herbs when coadministered with other drugs.
authors.affiliation: Department of Clinical Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. xiufenyang@163.net
authors.forename: Xiu-fen
authors.initials: XF
authors.lastname: Yang
authors.forename: Nai-ping
authors.initials: NP
authors.lastname: Wang
authors.forename: Fan-dian
authors.initials: FD
authors.lastname: Zeng
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D011564:Furocoumarins / Q000302:isolation & purification / Q000494:pharmacology*; D014453:Glucuronosyltransferase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D010946:Plants, Medicinal / Q000737:chemistry*; D027561:Salvia miltiorrhiza / Q000737:chemistry
chemical_list: D005419:Flavonoids; D011564:Furocoumarins; D003577:Cytochrome P-450 Enzyme System; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase