Antibiotic therapy in post-operative endophthalmitis.
Endophthalmitis following routine cataract surgery is a rare but potentially devastating complication resulting in severe vision loss. Various prophylaxis treatments have been tried. However, none have been demonstrated to completely eliminate the risk. The Endophthalmitis Vitrectomy Study (EVS) helped establish clinical guidelines in the treatment of post-operative endophthalmitis in a prospective, randomized, multicenter trial. The strength and limitation of the study will be discussed as well as the current knowledge of the pharmacokinetics of intravitreous injection of antibiotics. Additionally, the common pathologic organisms, the use of antibiotic therapy, steroids, and vitrectomy will be discussed.
Wang
Robert C
RC
Massachusetts Eye and Ear Infirmary and the Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Lou
Peter L
PL
Ryan
Edward A
EA
Kroll
Arnold J
AJ
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D002387:Cataract Extraction / Q000009:adverse effects; D009877:Endophthalmitis / Q000188:drug therapy* / Q000382:microbiology; D015818:Eye Infections, Bacterial / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D011183:Postoperative Complications / Q000188:drug therapy* / Q000382:microbiology; D017410:Practice Guidelines as Topic
D000900:Anti-Bacterial Agents