title: Feasibility of ultra-low-dose multislice CT colonography for the detection of colorectal lesions: preliminary experience.
abstract: Our objective was to evaluate the feasibility of ultra-low-dose scanning for multislice CT colonography in the detection of colorectal lesions. Twenty-seven patients (14 men, 13 women) with clinical indication for conventional colonoscopy were recruited. Multislice spiral CT (Somatom Plus 4 Volume Zoom, Siemens, Germany) examinations were performed after standard oral colonoscopic preparation and colonic distension with room air. Images were acquired using 2.5-mm collimation, 3.0-mm slice thickness, standard reconstruction kernel, 140 kVp, and 10 mAs. Supine and prone acquisitions were obtained in all patients. Images were analyzed on a workstation by two gastrointestinal radiologists. Conventional colonoscopy was performed on the same day in all patients and represented the standard of reference. Total radiation exposure was also calculated. All colorectal cancers were correctly identified at CT colonography (9 of 9, sensitivity 100%). The CT colonography also detected 10 of 12 polyps (overall sensitivity 83.3%). Based on polyp diameter, the sensitivity for the detection of polyps 10 mm or larger was 100% (3 of 3); between 6 and 9 mm, 100% (3 of 3); and 5 mm or smaller, 66.6% (4 of 6). Total radiation exposure for prone and supine acquisitions combined was 1.7 mSv (for men) and 2.3 mSv (for women). Although preliminary, our experience suggests that ultra-low-dose scanning for multislice CT colonography is feasible. This technique provides a sensitivity comparable to that of previous experiences with CT colonography but with a 40-70% reduction of the radiation dose delivered to patients.
authors.affiliation: Department of Radiology, University of Rome La Sapienza, Policlinico Umberto I, Viale Regina Elena, 324, 00161 Rome, Italy. riannaccone@tiscalinet.it
authors.forename: Riccardo
authors.initials: R
authors.lastname: Iannaccone
authors.forename: Andrea
authors.initials: A
authors.lastname: Laghi
authors.forename: Carlo
authors.initials: C
authors.lastname: Catalano
authors.forename: Filippo
authors.initials: F
authors.lastname: Mangiapane
authors.forename: Francesca
authors.initials: F
authors.lastname: Piacentini
authors.forename: Roberto
authors.initials: R
authors.lastname: Passariello
mesh_terms: D002086:Butylscopolammonium Bromide; D003111:Colonic Polyps / Q000175:diagnosis / Q000000981:diagnostic imaging; D023881:Colonography, Computed Tomographic / Q000379:methods; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D003287:Contrast Media; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007472:Iohexol; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics; D011829:Radiation Dosage; D011835:Radiation Protection; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D010276:Parasympatholytics; D002086:Butylscopolammonium Bromide; D007472:Iohexol