title: Sorption of thiotepa to polyurethane catheter causes falsely elevated plasma levels.
abstract: Central venous access catheters are commonly used in clinical oncology. The double lumen variant is applied in pharmacokinetic studies for simultaneous administration and blood sampling when frequent blood collections are necessary. Occlusion of one lumen, a common complication, necessitates the investigator perform blood sampling through the administration lumen after interrupting the infusion. Plasma concentrations measured in this sample can be influenced by sorption of the previously infused compound to the catheter lumen. In this study, the quality of cyclophosphamide, thiotepa, and carboplatin plasma concentrations is investigated when sampling is performed through the administration lumen.
authors.affiliation: Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute/Slotervaart Hospital, The Netherlands. apmil@slz.nl
authors.forename: Milly E
authors.initials: ME
authors.lastname: de Jonge
authors.forename: Ron A A
authors.initials: RA
authors.lastname: Mathôt
authors.forename: Selma M
authors.initials: SM
authors.lastname: van Dam
authors.forename: Sjoerd
authors.initials: S
authors.lastname: Rodenhuis
authors.forename: Jos H
authors.initials: JH
authors.lastname: Beijnen
mesh_terms: D000042:Absorption; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000379:methods*; D002408:Catheters, Indwelling; D006801:Humans; D011140:Polyurethanes / Q000493:pharmacokinetics*; D013350:Subclavian Vein / Q000378:metabolism; D013852:Thiotepa / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D011140:Polyurethanes; D013852:Thiotepa