Readily prepared chiral P,N ligands and their applications in cu-catalyzed enantioselective conjugate additions.
A new type of phosphite-pyridine (P,N) ligand derived from (S)-NOBIN and (S)-BINOL was employed in Cu(I)-catalyzed conjugate addition of diethylzinc to chalcones. The new P,N ligands were highly efficient in the copper-catalyzed enantioselective 1,4-conjugate additions of diethylzinc to acyclic enones, and up to 97% ee was achieved.
Hu
Yuanchun
Y
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, People's Republic of China.
Liang
Xinmiao
X
Wang
Junwei
J
Zheng
Zhuo
Z
Hu
Xinquan
X