title: Cytogenetic findings in familial B-cell chronic lymphocytic leukemia: a report of two cases in a family.
abstract: Familial B-cell chronic lymphocytic (B-CLL) leukemia has been defined as an entity epidemiologically different from sporadic B-CLL. Cytogenetic abnormalities in familial B-CLL, studied either by conventional cytogenetics or by interphase fluorescence in situ hybridization (i-FISH), have rarely been reported. We report a two-case family affected with B-CLL showing two different abnormal karyotypes detected by conventional cytogenetics [46,XX,del(7)(q32) and 46,XY,add(1)(p36),del(6)(q21)] but sharing a del(13)(q14) at the D13S319 locus, detected by interphase fluorescence in situ hybridization.
authors.affiliation: Laboratori de Citogenètica i Biologia Molecular, Servei de Patologia, Hospital del Mar, IMAS, Barcelona, Spain. bespinet@imas.imim.es
authors.forename: Blanca
authors.initials: B
authors.lastname: Espinet
authors.forename: Marta
authors.initials: M
authors.lastname: Salido
authors.forename: José Angel
authors.initials: JA
authors.lastname: Hernández
authors.forename: Lurdes
authors.initials: L
authors.lastname: Zamora
authors.forename: M Alba
authors.initials: MA
authors.lastname: Bosch
authors.forename: Sergi
authors.initials: S
authors.lastname: Serrano
authors.forename: Francesc
authors.initials: F
authors.lastname: Solé
mesh_terms: D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000235:genetics; D005260:Female; D017353:Gene Deletion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D035781:Siblings