title: Deep brain stimulation for Parkinson's disease: the experience of the Policlinico-San Paolo Group in Milan.
abstract: Thirty patients with idiopathic Parkinson's disease were treated with deep brain stimulation electrode in the subthalamic nucleus. After surgery, the patients' best mean Unified Parkinson's Disease Rating Scale (UPDRS III) scores (medictionOFF-stimulatorON versus preoperative medicationOFF) were 77+/-14% at 3 months ( n=20 patients) and 72+/-14% at 12 months follow-up ( n=16). The mean reduction in therapy (expressed in levodopa dose equivalents in mg) was 68+/-25% at 12 months. Postoperative complications were rare, mostly mild, and reversible. Therapeutic success depends on a multidisciplinary team approach, meticulous patient selection, including patients' cognitive, psychic, and behavioral status, and patient and family lifestyles.
authors.affiliation: Ospedale San Paolo, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Tamma
authors.forename: P
authors.initials: P
authors.lastname: Rampini
authors.forename: M
authors.initials: M
authors.lastname: Egidi
authors.forename: E
authors.initials: E
authors.lastname: Caputo
authors.forename: M
authors.initials: M
authors.lastname: Locatelli
authors.forename: A
authors.initials: A
authors.lastname: Pesenti
authors.forename: V
authors.initials: V
authors.lastname: Chiesa
authors.forename: G
authors.initials: G
authors.lastname: Ardolino
authors.forename: G
authors.initials: G
authors.lastname: Foffani
authors.forename: B
authors.initials: B
authors.lastname: Meda
authors.forename: M
authors.initials: M
authors.lastname: Pellegrini
authors.forename: A
authors.initials: A
authors.lastname: Priori
mesh_terms: D004599:Electric Stimulation Therapy / Q000379:methods*; D004567:Electrodes, Implanted; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D018579:Patient Selection; D011182:Postoperative Care; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D016896:Treatment Outcome