Mitotic entry: tipping the balance.
In the eukaryotic cell cycle, the G2-M transition is regulated by a counteracting kinase/phosphatase mechanism. A novel player, Tome-1, has now been found to trigger entry into mitosis by interfering with this kinase/phosphatase 'switch'.
Kraft
Claudine
C
Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. kraftcl@imp.univie.ac.at
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism* / Q000502:physiology; D016195:G2 Phase / Q000502:physiology*; D008938:Mitosis / Q000502:physiology*; D044843:SKP Cullin F-Box Protein Ligases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism; D014981:Xenopus; D029867:Xenopus Proteins / Q000378:metabolism* / Q000502:physiology
C473797:CDCA3 protein, Xenopus; D018797:Cell Cycle Proteins; D029867:Xenopus Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D044843:SKP Cullin F-Box Protein Ligases