[Livedo-like dermatitis (Nicolau's syndrome) after injection of Copolymer-1 (Glatiramer acetate)].
We report the first case of a 33-year-old woman with multiple sclerosis, who developed a livedo-like dermatitis after injection of Copolymere-1. This disease is characterized by the development of acute violent pain during or immediately after injection, and a livedo-like plaque followed by necrosis corresponding to an arterial ischemia by vasospasm or thrombosis. Early treatment with vasoactive and anticoagulation agents is required. Surgery may be necessary.
Gaudez
C
C
Service de Dermatologie, Hôpital Tenon, Paris. francois.caroline.gaudez@wanadoo.fr
Regnier
S
S
Aractingi
S
S
Heinzlef
O
O
D000208:Acute Disease; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001132:Arm / Q000098:blood supply; D001916:Brachial Artery / Q000473:pathology; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D000068717:Glatiramer Acetate; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007269:Injections, Intra-Arterial; D007511:Ischemia / Q000139:chemically induced; D009103:Multiple Sclerosis / Q000188:drug therapy; D009336:Necrosis; D010146:Pain / Q000139:chemically induced; D010455:Peptides / Q000008:administration & dosage / Q000009:adverse effects*; D013577:Syndrome
D000925:Anticoagulants; D007166:Immunosuppressive Agents; D010455:Peptides; D000068717:Glatiramer Acetate