[A five-year-old girl with epilepsy showing forced normalization due to zonisamide].
A case of forced normalization in childhood is presented. When zonisamide was administered to a five-year-old girl with intractable epilepsy, disappearance of seizures was accompanied by severe psychotic episodes such as communication disturbance, personal relationship failure, and stereotyped behavior, which continued after the withdrawal of zonisamide. These symptoms gradually improved by administration of fluvoxamine, however epileptic attacks reappeared. Although most patients with forced normalization are adult and teenager, attention should be paid to this phenomenon as adverse psychotic effects of zonisamide even in young children. Fluvoxamine may be effective for the symptoms.
Hirose
Mieko
M
Department of Pediatrics, Tohoku University School of Medicine, Sendai. mhirose@ped.med.tohoku.ac.jp
Yokoyama
Hiroyuki
H
Haginoya
Kazuhiro
K
Iinuma
Kazuie
K
D000927:Anticonvulsants / Q000009:adverse effects*; D002653:Child Behavior Disorders / Q000139:chemically induced* / Q000188:drug therapy; D002675:Child, Preschool; D003147:Communication Disorders / Q000139:chemically induced; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D016666:Fluvoxamine / Q000627:therapeutic use; D006801:Humans; D007555:Isoxazoles / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000188:drug therapy; D000078305:Zonisamide
D000927:Anticonvulsants; D007555:Isoxazoles; D000078305:Zonisamide; D016666:Fluvoxamine