title: Telomeres in cancer and aging: lessons from the mouse.
abstract: The analysis of mice deficient in telomerase activity has allowed to directly test the relevance of telomeres and telomerase in tumor development and aging in the context of a mammalian organism. More recently, mice with impaired telomere capping due to abrogation of telomere-binding proteins have been also characterized. Here, I will discuss these studies, as well as their implications for putative therapies based of telomerase inhibition of telomerase re-introduction for cancer or age-related diseases, respectively.
authors.affiliation: Department of Immunology and Oncology, National Centre of Biotechnology, E-28049, Madrid, Spain. mblasco@cnb.uam.es <mblasco@cnb.uam.es>
authors.forename: María A
authors.initials: MA
authors.lastname: Blasco
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D051379:Mice; D008822:Mice, Transgenic; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics*; D019098:Telomerase / Q000235:genetics*; D016615:Telomere / Q000235:genetics*; D034501:Telomere-Binding Proteins / Q000235:genetics; D015854:Up-Regulation
chemical_list: D034501:Telomere-Binding Proteins; D019098:Telomerase