Synthesis of fused oxabicyclic systems by metal-catalyzed intramolecular addition of 1,3-cycloalkyldiones to alkynes.
[reaction: see text] Readily available 4-propargyl-1,3-cyclohexanediones and cyclopentanediones can be chemo- and regioselectively cycloisomerized to synthetically appealing fused oxabicyclic systems by simply stirring at room temperature with catalytic amounts of an appropriate metal complex.
Gulías
Moisés
M
Departamento de Química Orgánica y Unidad Asociada al CSIC, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Rodríguez
J Ramón
JR
Castedo
Luis
L
Mascareñas
José L
JL