title: The FimH A27V mutation is pathoadaptive for urovirulence in Escherichia coli B2 phylogenetic group isolates.
abstract: Correlations between FimH mutations and virulence were established by studying a collection of human commensal and extraintestinal pathogenic Escherichia coli natural isolates. Pathoadaptive (A27V and, to a lesser extent, A119V) and "commensal-adaptive" (A202V) mutations were evidenced in B2 phylogenetic group strains. fimH phylogenetic analysis indicates that these pathoadaptive mutations occurred several times.
authors.affiliation: INSERM U458, Hôpital Robert Debré Centre d'Etude du Polymorphisme Humain, Hôpital Saint Louis, Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Hommais
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Gouriou
authors.forename: Christine
authors.initials: C
authors.lastname: Amorin
authors.forename: Hung
authors.initials: H
authors.lastname: Bui
authors.forename: Mohamed Chérif
authors.initials: MC
authors.lastname: Rahimy
authors.forename: Bertrand
authors.initials: B
authors.lastname: Picard
authors.forename: Erick
authors.initials: E
authors.lastname: Denamur
mesh_terms: D018830:Adhesins, Escherichia coli / Q000235:genetics* / Q000502:physiology; D004926:Escherichia coli / Q000145:classification / Q000472:pathogenicity*; D036781:Fimbriae Proteins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D009154:Mutation; D010802:Phylogeny; D014552:Urinary Tract Infections / Q000382:microbiology*; D014774:Virulence
chemical_list: D018830:Adhesins, Escherichia coli; C058769:fimH protein, E coli; D036781:Fimbriae Proteins