In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum.
The in vitro antimalarial activity against Plasmodium falciparum and heme polymerization were evaluated for ten metalloporphyrins: gallium protoporphyrin IX (GaPPIX), sodium salt of gallium protoporphyrin IX, silver protoporphyrin IX, palladium protoporphyrin IX, cobalt protoporphyrin IX, manganese protoporphyrin IX, tin protoporphyrin IX (SnPPIX), chromium protoporphyrin IX, gallium deuteroporphyrin IX (GaDPIX) and gallium hematoporphyrin IX. Metalloporphyrins inhibited parasite growth with 50% inhibitory concentrations (IC(50)) ranging from 15.5 microM to 190 microM. In trophozoite lysate-mediated heme polymerization assays, SnPPIX, GaPPIX and GaDPIX exerted potent inhibitory activity similar to that of artemisinin and chloroquine.
Begum
Khurshida
K
Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700-8530, Japan.
Kim
Hye-Sook
HS
Kumar
Veena
V
Stojiljkovic
Igor
I
Wataya
Yusuke
Y
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D006418:Heme / Q000378:metabolism*; D016778:Malaria, Falciparum / Q000469:parasitology; D008665:Metalloporphyrins / Q000737:chemistry / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D011108:Polymers / Q000378:metabolism
D000962:Antimalarials; D008665:Metalloporphyrins; D011108:Polymers; D006418:Heme