title: When ubiquitin meets ubiquitin receptors: a signalling connection.
abstract: Ubiquitylation is emerging as a versatile device for controlling cellular functions. Here, we propose that monoubiquitylation is rapidly induced by signalling events and allows the establishment of protein-protein interactions between monoubiquitylated proteins and partners that contain distinct ubiquitin-binding domains. We also put forward speculative models for the regulation of monoubiquitylation versus polyubiquitylation.
authors.affiliation: Istituto Europeo di Oncologia, Via Ripamonti 435, 20141, Milan, Italy. pdifiore@ieo.it
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Di Fiore
authors.forename: Simona
authors.initials: S
authors.lastname: Polo
authors.forename: Kay
authors.initials: K
authors.lastname: Hofmann
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D011992:Endosomes / Q000502:physiology; D005199:Fanconi Anemia / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D025801:Ubiquitin / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D025801:Ubiquitin