The role of Kit-ligand in melanocyte development and epidermal homeostasis.
Kit-ligand (Kitl) also known as steel factor, stem cell factor and mast cell growth factor plays a crucial role in the development and maintenance of the melanocyte lineage in adult skin. Kitl exerts permanent survival, proliferation and migration functions in Kit receptor-expressing melanocytes. A comprehensive overview over the differential roles of Kitl in melanocyte development and homeostasis is provided. I discuss species-specific differences of the Kitl/Kit signalling system, regulation at the transcriptional level and also covering the regulation of cell surface Kitl presentation by cytoplasmic targeting sequences. In addition, recent studies evoked the importance of Kitl misexpression in some hyperpigmented lesions that may open the avenue for Kitl-dependent treatment of pathological skin conditions.
Wehrle-Haller
Bernhard
B
Department of Pathology, Centre Medical Universitaire, Genève, Switzerland. bernhard.wehrle-haller@medecine.unige.ch
D000595:Amino Acid Sequence; D000818:Animals; D002455:Cell Division; D019070:Cell Lineage; D002465:Cell Movement; D002470:Cell Survival; D003593:Cytoplasm / Q000378:metabolism; D004817:Epidermis / Q000378:metabolism*; D006801:Humans; D008544:Melanocytes / Q000378:metabolism*; D008954:Models, Biological; D008969:Molecular Sequence Data; D009432:Neural Crest / Q000166:cytology / Q000378:metabolism; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000378:metabolism; D019089:Stem Cell Factor / Q000502:physiology*; D013329:Structure-Activity Relationship
D019089:Stem Cell Factor; D019009:Proto-Oncogene Proteins c-kit