Successful treatment of partial nephrogenic diabetes insipidus with thiazide and desmopressin.
OBJECTIVE
To clarify whether combination treatment with desmopressin (DDAVP) and thiazide was clinically effective in a patient with congenital nephrogenic diabetes insipidus (CNDI), we evaluated the treatment in a 7-year-old boy with CNDI who had demonstrated a partial response to DDAVP.


METHODS
Both volume of urine and the presence of nocturia were determined during treatment.


RESULTS
Neither the usual therapy of a low-salt diet and a thiazide nor intranasal therapy with a large dose of DDAVP was effective. However, combination treatment resulted in a decrease in urinary volume and the disappearance of nocturia.


CONCLUSIONS
DDAVP coupled with thiazide may be useful for CNDI in patients who have shown a partial response to DDAVP.
Mizuno
Haruo
H
Department of Pediatrics, Neonatology and Congenital Disorders, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan. hamizuno@med.nagoya-cu.ac.jp
Fujimoto
Shinji
S
Sugiyama
Yukari
Y
Kobayashi
Masanori
M
Ohro
Yoichiro
Y
Uchida
Shinichi
S
Sasaki
Sei
S
Togari
Hajime
H
D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D018500:Diabetes Insipidus, Nephrogenic / Q000150:complications / Q000188:drug therapy*; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D008297:Male; D012076:Renal Agents / Q000627:therapeutic use*; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome; D014237:Trichlormethiazide / Q000627:therapeutic use*; D014555:Urination Disorders / Q000188:drug therapy / Q000209:etiology
D004232:Diuretics; D012076:Renal Agents; D049993:Sodium Chloride Symporter Inhibitors; D003894:Deamino Arginine Vasopressin; D014237:Trichlormethiazide