Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men.
We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.
Gunnell
D
D
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, UK. D.J.Gunnel@bristol.ac.uk
Oliver
S E
SE
Peters
T J
TJ
Donovan
J L
JL
Persad
R
R
Maynard
M
M
Gillatt
D
D
Pearce
A
A
Hamdy
F C
FC
Neal
D E
DE
Holly
J M P
JM
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004032:Diet; D005247:Feeding Behavior; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000097:blood / Q000453:epidemiology*; D012307:Risk Factors
D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I