Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus.
A marine fungal isolate, identified as Wardomyces anomalus, was cultivated and found to produce two new xanthone derivatives, 2,3,6,8-tetrahydroxy-1-methylxanthone (1) and 2,3,4,6,8-pentahydroxy-1-methylxanthone (2), in addition to the known xanthone derivative 3,6,8-trihydroxy-1-methylxanthone (3) and the known fungal metabolite 5-(hydroxymethyl)-2-furanocarboxylic acid (4). The structures of all compounds were determined on the basis of extensive spectroscopic measurements (1D and 2D NMR, MS, UV, and IR). Compounds 1 and 4 showed significant antioxidant activities. The total extract and 1, 3, and 4 were shown to be inhibitors of p56(lck)tyrosine kinase.
Abdel-Lateff
Ahmed
A
Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, Germany.
Klemke
Christine
C
König
Gabriele M
GM
Wright
Anthony D
AD
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry* / Q000145:classification; D054303:HIV Reverse Transcriptase / Q000187:drug effects*; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000187:drug effects*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044004:Xanthones
C478282:2,3,4,6,8-pentahydroxy-1-methylxanthone; C478281:2,3,6,8-tetrahydroxy-1-methylxanthone; D000975:Antioxidants; D014966:Xanthenes; D044004:Xanthones; C009689:xanthone; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D054303:HIV Reverse Transcriptase