Innate immunity and pathogen-host interaction.
The skin and contiguous mucosal surfaces define the primary locus of interaction between host and micro-organisms. In this review, we focus on the innate immune system in the mucosa, which manages to deal with invading pathogens, the mechanisms that organisms have evolved in order to circumvent this primary defensive barrier and, finally, potential therapeutic manipulation of the innate immune system that was the focus of meeting at a Euroconference/Workshop on "Novel Strategies of Mucosal Immunisation through Exploitation of Mechanisms of Innate Immunity in Pathogen-Host Interaction", which was held in Siena, Italy, November 2002.
Basset
Christelle
C
Department of Medical Microbiology, Windeyer Institute of Medical Sciences, Royal Free and University College London Medical School, London, UK. c.basset@ucl.ac.uk
Holton
John
J
O'Mahony
Rachel
R
Roitt
Ivan
I
D000818:Animals; D018925:Chemokines / Q000502:physiology; D037222:Collectins / Q000502:physiology; D003165:Complement System Proteins / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D003713:Dendritic Cells / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D007694:Killer Cells, Natural / Q000276:immunology; D008407:Mast Cells / Q000502:physiology; D008562:Membrane Glycoproteins / Q000502:physiology; D009504:Neutrophils / Q000276:immunology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D051193:Toll-Like Receptors
D018925:Chemokines; D037222:Collectins; D016207:Cytokines; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors; D003165:Complement System Proteins