title: Planning for remodelling: nuclear architecture, chromatin and chromosomes.
abstract: DNA sequences occupy three-dimensional positions and their architecture is related to gene expression, gene-protein interactions and epigenetic processes. The recent analysis of chromosome 4 in Arabidopsis interphase nuclei reveals that gene-rich, undermethylated DNA is composed of active loops of 200 to 2000 kb associated with acetylated histones, providing a well-defined model system to study chromatin in its nuclear context.
authors.affiliation: Department of Biology, University of Leicester, Leicester LE1 7RH, UK. phh4@le.ac.uk
authors.forename: J S
authors.initials: JS
authors.lastname: Heslop-Harrison
mesh_terms: D017360:Arabidopsis / Q000166:cytology / Q000235:genetics; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D002843:Chromatin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D032461:Chromosomes, Plant / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018744:DNA, Plant / Q000032:analysis / Q000235:genetics; D018506:Gene Expression Regulation, Plant
chemical_list: D002843:Chromatin; D018744:DNA, Plant