[Current progress of phenotypic modulation of vascular smooth muscle cells].
Proliferation and migration of vascular smooth muscle cells were the common pathological feature of development and progression of atherosclerosis, hypertension and vascular restenosis. Phenotypic modulation of vascular smooth muscle cells was the basis of its proliferation and migration. So, understanding the mechanisms of phenotypic modulation of these cells may be helpful to prevent and treat the diseases mentioned above. This paper will review the influence factors, signal transduction and transcription factors involved in phenotypic modulation of vascular smooth muscle cells.
Li
Qi
Q
Hebei Laboratory of Medical Biotechnology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017.
Wen
Jin-Kun
JK
Zheng
Bin
B
D000818:Animals; D002478:Cells, Cultured; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D010641:Phenotype; D010766:Phosphorylation; D051381:Rats; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology
D014157:Transcription Factors