title: Specification of dorsal telencephalic character by sequential Wnt and FGF signaling.
abstract: Dorsoventral patterning of the telencephalon is established early in forebrain development and underlies many of the regional subdivisions that are critical to the later organization of neural circuits in the cerebral cortex and basal ganglia. Sonic hedgehog (Shh) is involved in the generation of the ventral-most telencephalic cells, but the identity of the extrinsic signal(s) that induce dorsal character in telencephalic cells is not known. Here we show in chick embryos that sequential Wnt and fibroblast growth factor (FGF) signaling specifies cells of dorsal telencephalic character.
authors.affiliation: Umeå Center for Molecular Medicine, Building 6M, 4th floor, Umeå University, S-901 87 Umeå, Sweden.
authors.forename: Lena
authors.initials: L
authors.lastname: Gunhaga
authors.forename: Matthew
authors.initials: M
authors.lastname: Marklund
authors.forename: My
authors.initials: M
authors.lastname: Sjödal
authors.forename: Jen-Chih
authors.initials: JC
authors.lastname: Hsieh
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Jessell
authors.forename: Thomas
authors.initials: T
authors.lastname: Edlund
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D002454:Cell Differentiation; D002642:Chick Embryo; D004475:Ectoderm / Q000166:cytology / Q000502:physiology; D004627:Embryonic Induction / Q000502:physiology*; D004848:Epithelium; D005136:Eye Proteins; D005346:Fibroblast Growth Factors / Q000145:classification / Q000235:genetics / Q000502:physiology*; D051157:Frizzled Receptors; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D007150:Immunohistochemistry; D017403:In Situ Hybridization / Q000379:methods; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009924:Organ Culture Techniques; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D011506:Proteins / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D011758:Pyrroles / Q000494:pharmacology; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology; D012097:Repressor Proteins; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D013234:Stem Cells / Q000378:metabolism; D013687:Telencephalon / Q000166:cytology / Q000196:embryology / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D000099260:Empty Spiracles Homeobox Proteins
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D019485:Bone Morphogenetic Proteins; D005136:Eye Proteins; D005346:Fibroblast Growth Factors; D051157:Frizzled Receptors; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D011506:Proteins; D011518:Proto-Oncogene Proteins; D011758:Pyrroles; D017468:Receptors, Fibroblast Growth Factor; D012097:Repressor Proteins; D014157:Transcription Factors; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D000099260:Empty Spiracles Homeobox Proteins; C102641:Mrg1 protein, mouse; C102938:Neurog2 protein, mouse; C000605732:Pax6 protein, mouse; C105686:SU 5402; C491173:meis2b protein, zebrafish