title: Mean arterial pressure and pulse pressure are associated with different clinical parameters in chronic haemodialysis patients.
abstract: The mean arterial pressure (MAP) usually serves as an expression of blood pressure in patients on chronic haemodialysis (PCHD), instead of using solely systolic or diastolic pressure. Pulse pressure (PP) has been recognized as an important correlate of mortality in PCHD. We conducted this study in order to demonstrate clinical and biochemical determinants and variability of predialysis and postdialysis MAP and PP values. A total of 136 single haemodialysis (HD) treatments in 23 subjects (PCHD, 11 male and 12 female patients) were processed during 15 months. MAP before HD was in negative correlation with haemoglobin (P<0.001) and body mass index (BMI) (P<0.001), and in positive correlation with weekly erythropoietin dosage (P=0.017). MAP after HD was in negative correlation with haemoglobin (P<0.001), ultrafiltration per HD (P=0.015), and BMI (P=0.001), and in positive correlation with weekly erythropoietin dosage (P=0.003). PP before HD was in negative correlation with parathyroid hormone (PTH) level (P=0.020), haemoglobin (P<0.001), ultrafiltration per HD (P=0.001), and years on the chronic HD treatment (P=0.001), and in positive correlation with weekly erythropoietin dosage (P<0.001) and age (P<0.001). PP after HD was in significant negative correlation with PTH (P=0.015), haemoglobin (P=0.005), ultrafiltration per HD (P<0.001), BMI (P=0.003), and in positive correlation with weekly erythropoietin dosage (P<0.001) and age (P=0.004). Multiple regression analyses unveiled the strongest and negative correlations between MAP before HD and BMI (beta=-0.37, P=0.01); MAP after HD and haemoglobin (beta=-0.36, P=0.01); PP after HD and ultrafiltration/body weight ratio (beta=-0.41, P<0.001). The strongest and positive correlation was found between PP before HD and erythropoietin dosage per week (beta=0.51, P&<0.001). In conclusion, our findings support the assumption that PP and MAP are associated with different clinical parameters. PP values have advantages as the method of blood pressure expression.
authors.affiliation: Haemodialysis Department, Medical Center Trogir, Trogir, Croatia. vedkovac@inet.hr
authors.forename: V
authors.initials: V
authors.lastname: Kovacic
authors.forename: L
authors.initials: L
authors.lastname: Roguljic
authors.forename: V
authors.initials: V
authors.lastname: Kovacic
authors.forename: B
authors.initials: B
authors.lastname: Bacic
authors.forename: T
authors.initials: T
authors.lastname: Bosnjak
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D001798:Blood Proteins / Q000187:drug effects / Q000378:metabolism; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D002908:Chronic Disease; D003928:Diabetic Nephropathies / Q000503:physiopathology / Q000628:therapy; D004921:Erythropoietin / Q000008:administration & dosage; D005260:Female; D005921:Glomerulonephritis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008297:Male; D010758:Phosphorus / Q000378:metabolism; D011704:Pyelonephritis / Q000503:physiopathology / Q000628:therapy; D012044:Regression Analysis; D006435:Renal Dialysis; D012737:Sex Factors; D013223:Statistics as Topic; D013997:Time Factors; D016896:Treatment Outcome; D014462:Ultrafiltration
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D008076:Cholesterol, HDL; D004921:Erythropoietin; D010758:Phosphorus; D000469:Alkaline Phosphatase