title: [Calcitonin gene-related peptide changes in efferent vestibular system during vestibular compensation].
abstract: OBJECTIVE
  To investigate the calcitonin gene-related peptide (CGRP) effect on efferent vestibular system during pathological state of vestibular afferent system.
  
  
  METHODS
  An animal model of vestibular compensation was made by administration of streptomycin to rat vestibular organ to destroy unilateral vestibular function. Change of CGRP in efferent vestibular neurons in all processes from vestibular disorder to vestibular compensation was observed utilizing ABC method of immunohistochemical technique.
  
  
  RESULTS
  Efferent vestibular neurons of normal animals showed low immunoreactivity to CGRP. The number of CGRP immunoreactivity neurons and level of CGRP immunoreactivity increased in efferent vestibular system during vestibular disorder, and these changes decreased with vestibular compensation.
  
  
  CONCLUSIONS
  Activity of CGRP in efferent vestibular system plays a regular role on accelerating vestibular compensation.
authors.affiliation: Hearing Laboratory of Ministry of Hygiene, Eye Ear Nose & Throat Hospital of Shanghai Medical University, Shanghai 200031.
authors.forename: F
authors.initials: F
authors.lastname: Chi
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: K
authors.initials: K
authors.lastname: Li
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism* / Q000502:physiology; D004195:Disease Models, Animal; D008297:Male; D009476:Neurons, Efferent / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014725:Vestibular Nerve / Q000166:cytology / Q000378:metabolism*; D014722:Vestibule, Labyrinth / Q000293:injuries* / Q000473:pathology
chemical_list: D015740:Calcitonin Gene-Related Peptide