title: Features of abnormal choroidal circulation in central serous chorioretinopathy.
abstract: OBJECTIVE
  To evaluate abnormalities in the choroidal circulation in cases of central serous chorioretinopathy (CSC).
  
  
  METHODS
  A complete clinical ophthalmological examination was performed using simultaneous fluorescein and indocyanine green (ICG) angiography with a confocal scanning laser ophthalmoscopy and the digital images analysed in 36 consecutive patients with acute CSC. To quantify the choroidal circulation, the foveal choroidal blood flow was measured in 11 patients using laser Doppler flowmetry.
  
  
  RESULTS
  Fluorescein angiography showed focal leakage from the retinal pigment epithelium in all patients. ICG angiography revealed delays in arterial filling in 27 eyes (75%), and fluorescein angiography showed small hypofluorescent points around the leakage in 27 eyes (75%). Abnormal choroidal hyperfluorescence was observed in 30 eyes (83%). The choroidal blood flow in eyes with CSC was 45% lower than in fellow eyes (p<0.01).
  
  
  CONCLUSIONS
  Decreased choroidal blood flow in CSC was demonstrated for the first time. The decreased choroidal blood flow might be correlated with the small, localised hypofluorescent areas, which may indicate non-perfused areas of the choriocapillaris that are frequently seen during ICG angiography.
authors.affiliation: Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan. kitaya@asahikawa-med.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Kitaya
authors.forename: T
authors.initials: T
authors.lastname: Nagaoka
authors.forename: T
authors.initials: T
authors.lastname: Hikichi
authors.forename: R
authors.initials: R
authors.lastname: Sugawara
authors.forename: K
authors.initials: K
authors.lastname: Fukui
authors.forename: S
authors.initials: S
authors.lastname: Ishiko
authors.forename: A
authors.initials: A
authors.lastname: Yoshida
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D002829:Choroid / Q000098:blood supply*; D015862:Choroid Diseases / Q000503:physiopathology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D018613:Microscopy, Confocal; D008875:Middle Aged; D012164:Retinal Diseases / Q000503:physiopathology*
chemical_list: D007208:Indocyanine Green