title: The effects of acarbose and Rumex patientia on liver ultrastructure in streptozotocin-induced diabetic (type II) rats.
abstract: The aim of this study was to investigate the effects of acarbose and Rumex patientia on liver ultrastructure in streptozotocin (STZ)-induced diabetic (type II) rats. Forty-two-day-old, neonatal Wistar albino rats were used. They were divided into six groups. STZ was injected into groups 4, 5 and 6 on postnatal day 2. Groups 1 and 5 received water, groups 2 and 6 received 2% decoction of R. patientia grain and groups 3 and 4 received 40 mg acarbose/100 g feed. During the experimental period, blood glucose levels were checked periodically and HbA1c levels were measured from cardiac blood at the end of the experiment. In addition, liver tissue was examined by electron microscopy. Our results showed that glucose and HbA1c levels, which are increased by STZ, were decreased by acarbose and R. patientia. In group 5, most of the mitochondria of hepatocytes were swollen and some hepatocytes contained lipid granules in their cytoplasm. In group 4, no pathological changes were observed in hepatocytes, but some lysosomes were found in their cytoplasms. In group 6, mitochondrial changes were minimal compared with those in group 5, and no lipid granules were observed in hepatocytes.
authors.affiliation: Faculty of Medicine, Department of Medical Biology, Osmangazi University, Eskisehir, Turkey. idegirmenci@ogu.edu.tr
authors.forename: I
authors.initials: I
authors.lastname: Degirmenci
authors.forename: S
authors.initials: S
authors.lastname: Kalender
authors.forename: M C
authors.initials: MC
authors.lastname: Ustuner
authors.forename: Y
authors.initials: Y
authors.lastname: Kalender
authors.forename: H V
authors.initials: HV
authors.lastname: Gunes
authors.forename: N
authors.initials: N
authors.lastname: Unal
authors.forename: A
authors.initials: A
authors.lastname: Basaran
mesh_terms: D020909:Acarbose / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D006442:Glycated Hemoglobin / Q000032:analysis; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000187:drug effects / Q000648:ultrastructure; D008933:Mitochondrial Swelling / Q000187:drug effects; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D031804:Rumex / Q000737:chemistry*
chemical_list: D020909:Acarbose; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D028321:Plant Preparations