Introduction: Mapping and control of complex cardiac arrhythmias.
This paper serves as an introduction to the Focus Issue on mapping and control of complex cardiac arrhythmias. We first introduce basic concepts of cardiac electrophysiology and describe the main clinical methods being used to treat arrhythmia. We then provide a brief summary of the main themes contained in the articles in this Focus Issue. In recent years there have been important advances in the ability to map the spread of excitation in intact hearts and in laboratory settings. This work has been combined with simulations that use increasingly realistic geometry and physiology. Waves of excitation and contraction in the heart do not always propagate with constant velocity but are often subject to instabilities that may lead to fluctuations in velocity and cycle time. Such instabilities are often treated best in the context of simple one- or two-dimensional geometries. An understanding of the mechanisms of propagation and wave stability is leading to the implementation of different stimulation protocols in an effort to modify or eliminate abnormal rhythms. (c) 2002 American Institute of Physics.
Christini
David J.
DJ
Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, and Department of Physiology and Biophysics, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021Centre for Nonlinear Dynamics, Department of Physiology, McGill University, 3655 Montreal, H3G1Y6, Quebec, Canada.
Glass
Leon
L