Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs.
Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin formation. Such combined inhibition avoids some of the disadvantages of selective COX-2 inhibitors and spares the gatrointestinal mucosa.
Martel-Pelletier
J
J
Osteoarthritis Research Unit, Centre hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montréal, Québec H2L 4M1 Canada. jm@martelpelletier.ca
Lajeunesse
D
D
Reboul
P
P
Pelletier
J-P
JP
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D004357:Drug Synergism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D015289:Leukotrienes / Q000502:physiology; D016859:Lipoxygenase Inhibitors / Q000627:therapeutic use*; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D011451:Prostaglandin-Endoperoxide Synthases