title: [Pathological changes in rabbit brain after traumatic head injuries with seawater immersion].
abstract: OBJECTIVE
  To observe the pathological impact of seawater on rabbit brain tissue with severe traumatic injury.
  
  
  METHODS
  Modified rabbit models of severe brain injury was utilized, in which the damaged brain tissues were subjected to immersion with fresh seawater for 30 min. A control group was set up in which the trauma was induced without subsequent seawater immersion. Tissue sampling was performed at the brain injury sites at 0, 3, 8 h after seawater immersion and the pathological changes in the brain tissues were observed by means of HE staining.
  
  
  RESULTS
  Severe traumatic brain edema occurred in both of the two groups, but the onset time of edema differed. In the control group, brain edema was obvious at 3 h after treatment and hardly aggravated at hour 8; while in seawater treatment group, severe brain edema occurred at 8 h after the treatment and aggravated progressively.
  
  
  CONCLUSIONS
  Seawater immersion delays the onset and peak of traumatic brain edema following severe brain injuries, but can eventually aggravate the traumatic edema.
authors.affiliation: Postgraduate Medical School of PLA, Beijing 100853, China. heatya@163.com
authors.forename: Li-bin
authors.initials: LB
authors.lastname: Yang
authors.forename: Xin-guang
authors.initials: XG
authors.lastname: Yu
authors.forename: Jun-jie
authors.initials: JJ
authors.lastname: Jing
authors.forename: Xin
authors.initials: X
authors.lastname: Lin
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D006259:Craniocerebral Trauma / Q000473:pathology*; D005260:Female; D007101:Immersion; D008297:Male; D011817:Rabbits; D012623:Seawater; D013997:Time Factors