title: Cardiac autonomic dysinnervation and myocardial blood flow in long-term Type 1 diabetic patients.
abstract: OBJECTIVE
  The aim of the study was to assess scintigraphically the relationship between myocardial blood flow response and sympathetic dysinnervation in long-term Type 1 diabetic patients. Effects of the iron chelator deferoxamine on myocardial blood flow were studied and they were investigated according to the presence of cardiac sympathetic dysfunction.
  
  
  METHODS
  Myocardial blood flow (MBF) was assessed with N-13 ammonia positron emission tomography in 13 long-term Type 1 diabetic patients and 13 control subjects at rest and in response to sympathetic stimulation (cold pressor test (CPT)). In diabetic patients, the study was repeated after preinfusion with deferoxamine. Furthermore, 123I metaiodobenzylguanidine (MIBG) scintigraphy was applied to assess regional cardiac sympathetic dysinnervation (uptake score 1 = normal, homogeneous uptake em leader 6 = no uptake).
  
  
  RESULTS
  In diabetic patients, MBF increased in response to CPT from 78 +/- 18 ml/100 g/min to 84 +/- 26 ml/100 g (8%, P < 0.001). Control subjects demonstrated an increase from 63 +/- 17 ml/100 g to 84 +/- 26 ml/100 g (33%, P < 0.001), respectively. Resting MBF was higher in diabetic patients than in control subjects (P < 0.001). In diabetic patients, increase in MBF in response to CPT was significant in regions with a MIBG uptake score of <or= 3. Regions with a MIBG uptake score of > 3 did not exhibit a significant increase in MBF in response to CPT. After administration of deferoxamine, the increase in MBF in response to CPT was 23% and the magnitude of increase was related to the MIBG uptake score (r = 0.40, P < 0.0001).
  
  
  CONCLUSIONS
  Myocardial blood flow response to sympathetic stimulation is significantly impaired in long-term Type 1 diabetes. After preinfusion with deferoxamine the impairment is partially reversed and a relationship between myocardial blood flow and the extent of cardiac sympathetic dysfunction is observed.
authors.affiliation: Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, der Technischen Universität München, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Hattori
authors.forename: J
authors.initials: J
authors.lastname: Rihl
authors.forename: F M
authors.initials: FM
authors.lastname: Bengel
authors.forename: S G
authors.initials: SG
authors.lastname: Nekolla
authors.forename: E
authors.initials: E
authors.lastname: Standl
authors.forename: M
authors.initials: M
authors.lastname: Schwaiger
authors.forename: O
authors.initials: O
authors.lastname: Schnell
mesh_terms: D019797:3-Iodobenzylguanidine; D003676:Deferoxamine / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000294:innervation*; D006801:Humans; D007502:Iron Chelating Agents / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals
chemical_list: D007502:Iron Chelating Agents; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine; D003676:Deferoxamine