title: Inhibition mechanisms of hematophagous invertebrate compounds acting on the host blood coagulation and platelet aggregation pathways.
abstract: To facilitate blood feeding, hematophagous invertebrates have evolved a sophisticated array of physiological compounds that counteract homeostatic systems and inflammatory reactions of the vertebrate host. For this reason, hematophagous invertebrates possess a variety of anticoagulation components that are inhibitors of coagulant factors or antagonists of the platelet receptor. The examination of kinetic data and the crystal structure analysis have exposed the inhibition mechanisms for many of these anticoagulant reagents. Here, we attempt to classify the antihemostatic molecules and to focus on the kinetic approaches that have been instrumental in defining these mechanisms.
authors.affiliation: Department of Epidemiology and Biostatics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA.
authors.forename: Junko
authors.initials: J
authors.lastname: Urata
authors.forename: Hideki
authors.initials: H
authors.lastname: Shojo
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kaneko
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000737:chemistry* / Q000145:classification / Q000633:toxicity*; D001777:Blood Coagulation / Q000187:drug effects*; D007448:Invertebrates / Q000502:physiology*; D010974:Platelet Aggregation / Q000187:drug effects*
chemical_list: D000925:Anticoagulants