title: Thromboembolism prophylaxis and incidence of thromboembolic complications after laparoscopic surgery.
abstract: The aim of this prospective study was to assess the clinical thrombo-embolic risk in laparoscopic digestive surgery.
  
  
  METHODS
  The study prospectively included 2384 patients, who underwent laparoscopic surgery between June 1992 and June 1997. All patients received peri-operative low molecular weight heparin (LMWH) thromboprophylaxis. This regimen was administered until the patient resumed normal ambulatory activity.
  
  
  RESULTS
  Eight cases (0.33%) of deep vein thrombosis (DVT) were observed, but no pulmonary embolism was noted. In 6 cases (5 cholecystectomies with reverse Trendelenburg position and 1 inguinal hernia repair), the pneumoperitoneum was more than 2 h, and in 2 cases (1 rectopexy and 1 sigmoid colectomy for diverticulitis), more than 3 h. In 6 out of the 8 cases, the diagnosis of DVT was established after cessation of LMWH delivery, after the patients were discharged home, and before post-operative day 10.
  
  
  CONCLUSIONS
  During laparoscopic surgery, long operations and reverse Trendelenburg position are potentiating factors to DVT. Heparin prophylaxis for laparoscopic procedures should continue at least until discharge, and continued prophylaxis after discharge should only be considered in individual patients at continued high risk. We also recommend using graduated compression stockings, maintaining a relatively low insufflation pressure, keeping use of the reverse Trendelenburg position to a minimum, and intermittently releasing the pneumoperitoneum in longer procedures.
authors.affiliation: Department of Digestive Surgery, Paris University Hospital, Hôpital Jean Verdier AP-HP, 93143 Bondy, France. jean-marc.catheline@jvr.ap-hop-paris.fr
authors.forename: J M
authors.initials: JM
authors.lastname: Catheline
authors.forename: E
authors.initials: E
authors.lastname: Capelluto
authors.forename: J L
authors.initials: JL
authors.lastname: Gaillard
authors.forename: R
authors.initials: R
authors.lastname: Turner
authors.forename: G
authors.initials: G
authors.lastname: Champault
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use*; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000209:etiology; D012307:Risk Factors; D013923:Thromboembolism / Q000209:etiology / Q000517:prevention & control*; D020246:Venous Thrombosis / Q000209:etiology
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight