[The application of basic fibroblast growth factor to auricles of rabbits with compound injury].
OBJECTIVE
To study the role of basic fibroblast growth factor (bFGF) in the repair of irradiation- and surgery-induced auricle trauma.


METHODS
The bilateral auricles of New Zealand white rabbits were received surgical trauma and beta-active irradiation(90Sr-90Y), bFGF was then applied to the wound. The efficacy of bFGF on wound healing was compared with the control group.


RESULTS
On the 10th day after the trauma, the mean epithelalized area was (34.17 +/- 0.37) mm2 and the mean number of microvessels/high power field was (10.25 +/- 2.34) in the treated group, whereas both were (26.25 +/- 0.20) mm2 and (4.38 +/- 0.92) respectivety in the control group. There was a significant difference between the two groups (P < 0.05). On the 7th and 14th days after the trauma, the mean epithelialized area in the treated group was significantly different from that of the control group. The measurement by the image cytometry showed that the treated group had a mean nuclear peak area value of (38.28 +/- 7.23) micron 2 and the mean S-stage cell value of (31.28 +/- 10.35)%, and those of the control group were (28.02 +/- 8.13) micron 2 and (20.14 +/- 9.46)% respectively. There were significant differences (P < 0.05) between them.


CONCLUSIONS
Application of bFGF can, to a certain extent, accelerate the repair of irradiated and surgically injured soft tissue.
Shen
P
P
Department of Otorhinolaryngology, First Affiliated Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310003.
Zhou
M
M
Wang
H
H
D000287:Administration, Topical; D000818:Animals; D004195:Disease Models, Animal; D004431:Ear, External / Q000293:injuries* / Q000528:radiation effects; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D017695:Soft Tissue Injuries / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects
D016222:Fibroblast Growth Factor 2