title: Influence of SDZ RAD vs. MMF on gastric emptying in renal transplant recipients.
abstract: SDZ RAD and mycophenolate mofetil (MMF) are increasingly used in the prevention of renal allograft rejection. SDZ RAD, having a macrolide structure, and MMF, known with gastrointestinal side-effects, may have gastric motility modifying properties. Gastric emptying was examined 1 yr after renal transplantation in eight patients taking corticosteroids (CS), cyclosporin A (CsA) and SDZ RAD and six patients treated with CS, CsA and MMF. Comparing the two groups, no significant differences in gastric emptying of solids and liquids were noted. Compared with normal volunteers, solid gastric emptying was faster in the SDZ RAD group and similar in the MMF group. It is concluded that in stable renal transplant recipients treated with MMF, gastric emptying was normal. Because of the impact on drug absorption and gastrointestinal symptoms, further studies are indicated to corroborate the potential prokinetic properties of SDZ RAD.
authors.affiliation: Department of Medicine, Division of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium. bart.maes@wz.kuleuven.ac.be
authors.forename: Bart D
authors.initials: BD
authors.lastname: Maes
authors.forename: Pieter
authors.initials: P
authors.lastname: Evenepoel
authors.forename: Dirk
authors.initials: D
authors.lastname: Kuypers
authors.forename: Benny
authors.initials: B
authors.lastname: Geypens
authors.forename: Yvo
authors.initials: Y
authors.lastname: Ghoos
authors.forename: Yves
authors.initials: Y
authors.lastname: Vanrenterghem
mesh_terms: D001944:Breath Tests; D016022:Case-Control Studies; D016572:Cyclosporine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D000068338:Everolimus; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005938:Glucocorticoids / Q000627:therapeutic use; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use*; D020123:Sirolimus / Q000031:analogs & derivatives / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D000068338:Everolimus; D009173:Mycophenolic Acid; D020123:Sirolimus; D008775:Methylprednisolone