title: [Investigation of the nasal T/NK cell lymphomas in 14 cases].
abstract: OBJECTIVE
  To study the biologic behavior, pathologic features as well as clinic manifestations of the nasal T/NK cell lymphomas, and to provide experiences for the diagnosis and treatment of the tumor.
  
  
  METHODS
  Specimens of 23 cases lethal midline granulomas (LMG) were examined: (1) HE stain for immunohistochemical staining for TIA-1, CD43, CD20, CD3 epsilon, CD56 and in situ hybridization for EBV encoded small nuclear RNA(EBER1/2, Y017, DAK0). (2) The cases histories were reviewed.
  
  
  RESULTS
  (1) 14 cases were confirmed by histological features. In the 14 cases, tumor cells expressed TIA-1, CD56, CD3 epsilon, CD43, EBER1/2 positive. (2) Among them 8 cases (57%) showed special clinic features of LMG, Nasopharynx, pharynx and laryngeal involvement were found in other 6 cases. One case revealed lymphoid leukemia. In other 2 cases, gastrointestinal tract were involved. Hemophagocytic syndrome (HPS) complication happened in 1 case.
  
  
  CONCLUSIONS
  The tumor cells of nasal T/NK cell lymphomas expressed TIA-1, CD56, CD43, CD3 epsilon may suggest it originates from NK cell. The high association with EBV may suggest in situ hybridization. 57% patients showed that the special clinic features of the LMG, and gastrointestinal tract, bone marrow, peripheral blood were involved in some cases. One case complicated with hemophagocytic syndrome (HPS).
authors.affiliation: Department of Otorhingolaryngology, China-Japan Friendship Hospital, Beijing 100029, China. liudandan-ent@263.net
authors.forename: D
authors.initials: D
authors.lastname: Liu
authors.forename: T
authors.initials: T
authors.lastname: Li
authors.forename: D
authors.initials: D
authors.lastname: Yang
mesh_terms: D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology / Q000821:virology; D009669:Nose Neoplasms / Q000276:immunology / Q000473:pathology / Q000821:virology; D012189:Retrospective Studies