Differential-pulse polarography (DPP) determination of betamethasone valerate in dosage form.
The electrochemical reduction of betamethasone valerate (BV) in a pharmaceutical formulation containing neomycin has been carried out in Britton-Robinson buffer (BRB) (0.04 mol L(-1)) by differential-pulse polarography (DPP). BV exhibits a well-defined irreversible reduction peak at -1.03 V/ref. The influence of pH on the reduction of BV was studied in Britton-Robinson buffer (pH range 1.7-10). A method for the analysis of BV in BRB (0.04 mol L(-1)), which allows quantification over the range 3.9x10(-6)-1.1x10(-4) mol L(-1), was proposed and successfully applied to the determination of BV in tablets with mean recovery and relative standard deviation of 100.81% and 0.45%, respectively.
Belgaied
J-E
JE
Institut National des Sciences Appliquées et de Technologies, B.P. 676, 1080, Tunis Cedex, Tunisia. Jamel.Belgaied@insat.rnu.tn
D001624:Betamethasone Valerate / Q000032:analysis* / Q000737:chemistry*; D011048:Polarography / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012996:Solutions / Q000032:analysis / Q000737:chemistry; D013607:Tablets
D012996:Solutions; D013607:Tablets; D001624:Betamethasone Valerate