Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer.
In an anecdotal report, complete resolution of chemotherapy-induced nausea was seen in a patient with breast cancer, after she was placed on the anticonvulsant gabapentin. On this basis, we did an open-label study in which oral gabapentin 300 mg thrice daily was given for every other chemotherapy treatment in nine patients with breast cancer. Six of the nine reported at least a three-point improvement in peak delayed nausea (on an eight-point nausea scale), and three patients had complete resolution of nausea when taking gabapentin. This preliminary evidence shows that gabapentin might have a role in treatment of chemotherapy-induced nausea.
Guttuso
Thomas
T
Department of Neurology, Box 673, University of Rochester, Rochester, NY 14642, USA. thomas_guttuso@urmc.rochester.edu <thomas_guttuso@urmc.rochester.edu>
Roscoe
Joseph
J
Griggs
Jennifer
J
D000085:Acetates / Q000627:therapeutic use*; D000284:Administration, Oral; D000588:Amines; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D003509:Cyclohexanecarboxylic Acids; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D000077206:Gabapentin; D006801:Humans; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D004317:Doxorubicin; D003520:Cyclophosphamide