Evidence to support the existence of subgroups within the UK epidemic Clostridium difficile strain (PCR ribotype 1).
We used three different DNA fingerprinting techniques and clindamycin susceptibility testing to confirm that Clostridium difficile PCR ribotype I isolates can be divided into two subclones. This observation may permit a better understanding of the epidemiology and pathogenicity of C. difficile infection.
Fawley
W N
WN
Department of Microbiology, The University of Leeds and Leeds General Infirmary, Old Medical School, Leeds LS2 9JT, UK.
Freeman
J
J
Wilcox
M H
MH
D002981:Clindamycin / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000145:classification / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D003015:Clostridium Infections / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology; D016172:DNA Fingerprinting; D004196:Disease Outbreaks; D004739:England / Q000453:epidemiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D021521:Ribotyping
D002981:Clindamycin