title: Late bilateral temporal lobe necrosis after conventional radiotherapy.
abstract: A 63-year-old woman presented with radionecrosis in the bilateral temporal lobes manifesting as dementia about 30 years after undergoing conventional radiotherapy for pituitary adenoma. Computed tomography and magnetic resonance (MR) imaging showed edema and cystic lesions in both temporal lobes. The mass in the left temporal lobe was excised. MR imaging 12 days after surgery showed reduced edema. Her dementia had improved. Radionecrosis usually occurs between several months and a few years after radiotherapy. The incidence of radionecrosis is estimated as 5%, but may be higher with longer follow-up periods. Clinical reports have suggested that larger total doses of radiation are associated with earlier onset of delayed necrosis and the fractional dose is the most significant factor causing cerebral radionecrosis. Radionecrosis can occur long after conventional radiotherapy or stereotactic radiosurgery using a linac-based system or a gamma knife unit.
authors.affiliation: Department of Neurosurgery, Saiseikai Utsunomiya Hospital, Utsunomiya, Tochigi, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Hoshi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kagami
authors.forename: Ikurou
authors.initials: I
authors.lastname: Murase
authors.forename: Masashi
authors.initials: M
authors.lastname: Nakatsukasa
mesh_terms: D000236:Adenoma / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009336:Necrosis; D010911:Pituitary Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000473:pathology* / Q000601:surgery; D013702:Temporal Lobe / Q000473:pathology* / Q000601:surgery; D013997:Time Factors