Identification of novel H3 receptor (H3R) antagonists with cognition enhancing properties in rats.
Fox
G B
GB
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A, R4N5, 100 Abbott Park Rd., Abbott Park, Illinois 60064-6115, USA. gerard.b.fox@abbott.com
Pan
J B
JB
Faghih
R
R
Esbenshade
T A
TA
Lewis
A
A
Bitner
R S
RS
Black
L A
LA
Bennani
Y L
YL
Decker
M W
MW
Hancock
A A
AA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003071:Cognition / Q000187:drug effects*; D006633:Histamine Antagonists / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D018100:Receptors, Histamine H3 / Q000187:drug effects*; D012919:Social Behavior
C475225:4-((3-(4-(2-aminopropanoyl)-1-piperazinyl)propoxy)phenyl)cyclopropylmethanone; D006633:Histamine Antagonists; D007093:Imidazoles; C475226:N-(2-(4-(3-(4-(cyclopropylcarbonyl)phenoxy)propyl)-1-piperazinyl)-1-methyl-2-oxoethyl)-2-furamide; D010879:Piperazines; D018100:Receptors, Histamine H3; C115705:ciproxifan