title: Long-term prevention of estrus in the bitch and queen using chlormadinone acetate.
abstract: Estrus was prevented with weekly oral administration of 2 mg chlormadinone acetate for 2.0 to 9.8 y in bitches and queens. Abnormalities, including mammary or uterine disorders, or both, were noted in 7 out of 14 bitches and 9 out of 24 queens during this long-term treatment.
authors.affiliation: Laboratory of Theriogenology, Course of Veterinary Science, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan. tamada@vet.osakafu-u.ac.jp
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Tamada
authors.forename: Noritoshi
authors.initials: N
authors.lastname: Kawate
authors.forename: Toshio
authors.initials: T
authors.lastname: Inaba
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sawada
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002371:Cat Diseases / Q000139:chemically induced*; D002415:Cats; D002715:Chlormadinone Acetate / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D004971:Estrus / Q000187:drug effects* / Q000502:physiology; D005260:Female; D008321:Mammary Glands, Animal / Q000187:drug effects; D015674:Mammary Neoplasms, Animal / Q000139:chemically induced; D045167:Progesterone Congeners / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D012189:Retrospective Studies; D013997:Time Factors; D014591:Uterine Diseases / Q000139:chemically induced / Q000662:veterinary*
chemical_list: D045167:Progesterone Congeners; D002715:Chlormadinone Acetate