Liver ischemia: apoptosis as a central mechanism of injury.
Injuries due to cold and warm (normothermic) ischemia remain an important source of morbidity and mortality in liver surgery and transplantation. While the mechanisms of injury are complex, involving apoptotic and necrotic types of cell death, accumulating evidence points to a central role for various apoptotic pathways in mediating cell death following ischemia. A number of antiapoptotic strategies have been shown to confer a high degree of protection, including improved animal survival following long ischemic insult. The future may lie in the identification of practical and effective antiapoptotic strategies to enhance tolerance to ischemic injury.
Rüdiger
Hannes A
HA
Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.
Graf
Rolf
R
Clavien
Pierre-Alain
PA
D000818:Animals; D017209:Apoptosis; D006801:Humans; D008107:Liver Diseases / Q000473:pathology* / Q000601:surgery; D016031:Liver Transplantation; D015427:Reperfusion Injury / Q000473:pathology*