Phosphate absorption in Aplysia californica gut: glucocorticoid inhibition.
Apical membranes of Aplysia californica foregut epithelia contain a sodium-phosphate symporter. Dexamethasone inhibited the absorptive activity of the sodium-phosphate symporter, whereas amiloride had no effect on the sodium-phosphate symporter. It appears that glucocorticoids or their molluscan equivalent play a role in the overall regulation of phosphate homeostasis by the Aplysia californica gut.
Gerencser
George A
GA
Department of Physiology & Functional Genomics, College of Medicine, Box 100274 JHMHC, University of Florida, Gainesville, FL 32610, USA. gag@phys.med.ufl.edu
Loo
Stanley Y
SY
Robbins
Frank W
FW
Zhang
Jianliang
J
D000818:Animals; D001048:Aplysia / Q000378:metabolism*; D003907:Dexamethasone / Q000493:pharmacokinetics; D005938:Glucocorticoids / Q000493:pharmacokinetics*; D007408:Intestinal Absorption / Q000187:drug effects*; D010710:Phosphates / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012623:Seawater; D012964:Sodium / Q000378:metabolism; D027981:Symporters / Q000187:drug effects / Q000378:metabolism; D041742:Upper Gastrointestinal Tract / Q000187:drug effects* / Q000378:metabolism*
D005938:Glucocorticoids; D010710:Phosphates; D027981:Symporters; D003907:Dexamethasone; D012964:Sodium