title: Sir2: an NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: S
authors.initials: S
authors.lastname: Imai
authors.forename: F B
authors.initials: FB
authors.lastname: Johnson
authors.forename: R A
authors.initials: RA
authors.lastname: Marciniak
authors.forename: M
authors.initials: M
authors.lastname: McVey
authors.forename: P U
authors.initials: PU
authors.lastname: Park
authors.forename: L
authors.initials: L
authors.lastname: Guarente
mesh_terms: D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002843:Chromatin / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D020868:Gene Silencing; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D037761:Sirtuins / Q000235:genetics* / Q000378:metabolism*
chemical_list: D002843:Chromatin; D037761:Sirtuins; D006655:Histone Deacetylases