title: Leiomyosarcoma of the distal femur in a patient with a history of bilateral retinoblastoma: a case report and review of the literature.
abstract: We report a case of primary leiomyosarcoma of the distal femoral shaft arising in a patient who had undergone bilateral orbital enucleation for bilateral retinoblastoma several years previously. Radiography demonstrated an osteolytic, expansive lesion with cortical destruction anteriorly in the distal femoral shaft, and these findings were confirmed on CT. MR imaging revealed an expansive intramedullary lesion with cortical breakthrough and soft tissue extension. The occurrence of a second malignancy in patients with a history of bilateral retinoblastoma is well documented. Many different histological types have been described, with osteosarcoma and leiomyosarcoma occurring with the greatest frequency.
authors.affiliation: Department of Radiology, Vancouver General Hospital, 899 W. 12th Avenue, Vancouver, BC, V5Z 1M9, Canada.
authors.forename: R S
authors.initials: RS
authors.lastname: Ryan
authors.forename: R
authors.initials: R
authors.lastname: Gee
authors.forename: J X
authors.initials: JX
authors.lastname: O'Connell
authors.forename: A C
authors.initials: AC
authors.lastname: Harris
authors.forename: P L
authors.initials: PL
authors.lastname: Munk
mesh_terms: D015353:Eye Enucleation; D005266:Femoral Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000453:epidemiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000453:epidemiology*; D019572:Retinal Neoplasms / Q000601:surgery*; D012175:Retinoblastoma / Q000601:surgery*; D014057:Tomography, X-Ray Computed