title: Multiple spinal meningiomas after tamoxifen therapy: a case report.
abstract: We describe a rare case of multiple spinal meningiomas and evaluate the possible relationship with tamoxifen treatment. We observed a 74-year-old woman who showed a spastic paraparesis gradually developed in the last year. The patient underwent left mastectomy for a breast cancer ten years earlier and was treated with tamoxifen for four years after surgical intervention. Magnetic resonance imaging revealed three spinal meningiomas at C6-C7, D6-D7 and D9 levels. Taking in account the tumor-inducing properties of tamoxifen and the extreme rarity of multiple spinal meningiomas, we suggest that tamoxifen may be the cause play a role in the genesis of the spinal meningiomatosis in the observed patient. Therefore, we propose the long-term clinical and neurological surveillance of patients who assumed tamoxifen, even for a short time, in order to survey the possible appearance of secondary tumours.
authors.affiliation: IRCCS Neuromed, Via Atinense 18, I-86077 Pozzilli (IS), Italy.
authors.forename: G B
authors.initials: GB
authors.lastname: Colazza
authors.forename: G
authors.initials: G
authors.lastname: Di Gennaro
authors.forename: P P
authors.initials: PP
authors.lastname: Quarato
authors.forename: C
authors.initials: C
authors.lastname: Colonnese
authors.forename: A
authors.initials: A
authors.lastname: Mascia
authors.forename: M
authors.initials: M
authors.lastname: Manfredi
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000139:chemically induced* / Q000175:diagnosis; D008579:Meningioma / Q000139:chemically induced* / Q000175:diagnosis; D013629:Tamoxifen / Q000009:adverse effects*
chemical_list: D013629:Tamoxifen