title: Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity.
abstract: Physical interaction of T cells and dendritic cells (DCs) is essential for T cell proliferation and differentiation, but it has been unclear how this interaction is regulated physiologically. Here we show that DCs produce thromboxane A2 (TXA2), whereas naive T cells express the thromboxane receptor (TP). In vitro, a TP agonist enhances random cell movement (chemokinesis) of naive but not memory T cells, impairs DC-T cell adhesion, and inhibits DC-dependent proliferation of T cells. In vivo, immune responses to foreign antigens are enhanced in TP-deficient mice, which also develop marked lymphadenopathy with age. Similar immune responses were seen in wild-type mice treated with a TP antagonist during the sensitization period. Thus, TXA2-TP signaling modulates acquired immunity by negatively regulating DC-T cell interactions.
authors.affiliation: Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606-8501, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kabashima
authors.forename: Takahiko
authors.initials: T
authors.lastname: Murata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Matsuoka
authors.forename: Daiji
authors.initials: D
authors.lastname: Sakata
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Yoshida
authors.forename: Koko
authors.initials: K
authors.lastname: Katagiri
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Kinashi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Miyasaka
authors.forename: Hiroichi
authors.initials: H
authors.lastname: Nagai
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Ushikubi
authors.forename: Shuh
authors.initials: S
authors.lastname: Narumiya
mesh_terms: D000818:Animals; D002450:Cell Communication; D002465:Cell Movement; D003713:Dendritic Cells / Q000502:physiology*; D003877:Dermatitis, Contact / Q000209:etiology; D005260:Female; D018960:Hyaluronan Receptors / Q000032:analysis; D007109:Immunity / Q000502:physiology*; D008206:Lymphatic Diseases / Q000209:etiology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D017482:Receptors, Thromboxane / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*; D013928:Thromboxane A2 / Q000502:physiology*
chemical_list: D018960:Hyaluronan Receptors; D017482:Receptors, Thromboxane; D013928:Thromboxane A2