Plasmablastic lymphoma presenting in a human immunodeficiency virus-negative patient: a case report.
Plasmablastic lymphoma (PBL), an aggressive non-Hodgkin's lymphoma that carries a poor prognosis, previously has been identified almost exclusively in patients infected with the human immunodeficiency virus (HIV). We present a case of a 42-year-old HIV-negative patient presenting with an isolated nasal cavity mass, the typical presentation for PBL. The patient was given systemic chemotherapy, central nervous system prophylaxis, and consolidative locoregional radiotherapy and achieved a complete clinical response. This case suggests PBL should be considered in HIV-negative patients with characteristic findings.
Nguyen
D D
DD
Division of Oncology, Department of Medicine, Stanford University School of Medicine, 703 Welch Road, Rm H4, Palo Alto, CA 94304, USA.
Loo
B W
BW
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Tillman
G
G
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Natkunam
Y
Y
Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Cao
T M
TM
Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Vaughan
W
W
Department of Surgery, Stanford University Medical Center, Stanford, CA, USA.
Dorfman
R F
RF
Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Goffinet
D R
DR
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Jacobs
C D
CD
Division of Oncology, Department of Medicine, Stanford University School of Medicine, 703 Welch Road, Rm H4, Palo Alto, CA 94304, USA.
Advani
R H
RH
Division of Oncology, Department of Medicine, Stanford University School of Medicine, 703 Welch Road, Rm H4, Palo Alto, CA 94304, USA. radvani@stanford.edu.
D000328:Adult; D018023:HIV Seronegativity; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000473:pathology