[Mechanical research on effects of yishenqing on membranous nephropathy].
OBJECTIVE
To investigate the therapeutic effect and mechanism of Yishenqing on rabbit membranous nephropathy.


METHODS
The rabbit membranous nephropathy model was induced by cationic bovine serum albumin, and the immunity of mice together with urine volume and haemorheological property of rats were also estimated.


RESULTS
Yishenqing could significantly reduce the urinary protein content, preserve the renal function and pathologically restore the glomeruli. Moreover, its effects also include immunity enhancement, diuretic property and blood stasis amelioration.


CONCLUSIONS
Yishenqing has good effects on the rabbit membranous nephropathy, which is probably due to the effects of diuretic property, immunity enhancement and blood stasis amelioration.
Song
Yan
Y
Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Science, Peking University 100083, Beijing, China.
Ma
Jian
J
Li
Chang-ling
CL
D000818:Animals; D004232:Diuretics / Q000494:pharmacology; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
D004232:Diuretics; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal