title: Insulin-mediated capillary recruitment in skeletal muscle: is this a mediator of insulin action on glucose metabolism?
abstract: The possibility that insulin stimulates microvascular access for itself and glucose in muscle in vivo is discussed. The application of new techniques suggests that capillary recruitment is a normal part of insulin's action and that this process becomes impaired in insulin resistance. Exercise, which also leads to capillary recruitment, may involve a different mechanism than that used by insulin.
authors.affiliation: Biochemistry, Medical School, University of Tasmania, Private Bag 58, Hobart 7001, Australia. S.Rattigan@utas.edu.au
authors.forename: Stephen
authors.initials: S
authors.lastname: Rattigan
authors.forename: Eugene J
authors.initials: EJ
authors.lastname: Barrett
authors.forename: Michael G
authors.initials: MG
authors.lastname: Clark
mesh_terms: D000818:Animals; D002196:Capillaries / Q000187:drug effects / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000494:pharmacology / Q000502:physiology*; D007333:Insulin Resistance / Q000502:physiology; D018482:Muscle, Skeletal / Q000098:blood supply*
chemical_list: D007328:Insulin; D005947:Glucose