Clinical effects of inhibiting leukocyte adhesion with monoclonal antibody to intercellular adhesion molecule-1 (enlimomab) in the treatment of partial-thickness burn injury.
BACKGROUND
A randomized, prospective, multicenter, double-blind, placebo-controlled, phase II clinical trial was performed to determine whether inhibition of leukocyte adherence by administration of monoclonal antibody directed against intercellular adhesion molecule-1 would improve burn wound healing.


METHODS
One hundred ten patients with burn injury ranging from 10% to 30% total body surface area were enrolled. Fifty-six patients received placebo (saline) and 54 patients received murine monoclonal antibody to the human intercellular adhesion molecule-1 (enlimomab). Treatment was initiated within 6 hours of injury. Patients had three distinct partial-thickness wound sites assessed. Laser Doppler flowmetry was used to stratify wounds on the day of injury. Wounds were assessed for healing status on day 21 postburn and categorized as healed, nonhealed, or grafted.


RESULTS
Patients treated with enlimomab had a significantly increased percentage of wounds that healed spontaneously in less than 21 days overall and when stratified by burn wound laser Doppler blood flow readings for those wounds at greatest risk for nonhealing.


CONCLUSIONS
These results support the concept that leukocyte adherence is involved in the pathogenesis of burn wound necrosis and suggest a therapeutic mechanism for modulating the inflammatory response after the burn injury that may improve wound healing.
Mileski
William J
WJ
Department of Surgery, University of Texas Medical Branch, Galveston, 77555-1172, USA. wmileski@utmb.edu
Burkhart
Deborah
D
Hunt
John L
JL
Kagan
Richard J
RJ
Saffle
Jeffrey R
JR
Herndon
David N
DN
Heimbach
David M
DM
Luterman
Arnold
A
Yurt
Roger W
RW
Goodwin
Cleon W
CW
Hansborough
John
J
D000328:Adult; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D002056:Burns / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology*; D008297:Male; D016028:Receptors, Leukocyte-Adhesion / Q000037:antagonists & inhibitors*; D012044:Regression Analysis
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D016028:Receptors, Leukocyte-Adhesion; C474712:enlimomab; D018799:Intercellular Adhesion Molecule-1