Topical cidofovir for the treatment of dermatologic conditions: verruca, condyloma, intraepithelial neoplasia, herpes simplex and its potential use in smallpox.
Cidofovir is a new antiviral drug that has a broad spectrum of activity against several DNA viruses. Many of the disorders caused by these viruses do not have satisfactory therapy, and given the efficacy of this agent in treating many of these conditions, it holds great promise. It is hoped that ongoing studies will confirm the initial anecdotal reports regarding its therapeutic efficacy and lack of systemic side effects. It is also hoped that the cost to formulate and use cidofovir topically will eventually decrease to a level that will allow more widespread use of this drug.
Toro
Jorge R
JR
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Executive Plaza South, Room 7012, Rockville, MD 20892-7231, USA. torojo@exchange.nih.gov
Sanchez
Samuel
S
Turiansky
George
G
Blauvelt
Andrew
A
D000279:Administration, Cutaneous; D000287:Administration, Topical; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000188:drug therapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D000077404:Cidofovir; D003218:Condylomata Acuminata / Q000188:drug therapy; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006561:Herpes Simplex / Q000188:drug therapy; D006801:Humans; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy; D012899:Smallpox / Q000188:drug therapy; D014860:Warts / Q000188:drug therapy
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir