title: Coronary smooth muscle adaptation to exercise: does it play a role in cardioprotection?
abstract: Substantial evidence exists supporting the role of chronic exercise in reducing the incidence and severity of coronary vascular disease. Physical inactivity is an independent risk factor for coronary heart disease suggesting that the cardioprotective effect of exercise is due, in part, to an intrinsic adaptation within the coronary vasculature. Surprisingly, a paucity of information exists regarding the intrinsic cellular changes within the coronary vasculature associated with exercise training and even less is known regarding the effect of physical activity on long-term phenotypic modulation of coronary smooth muscle (CSM). The purpose of this symposium is to provide a concise update on the current knowledge regarding CSM adaptation to exercise training and the potential for these adaptations to contribute to exercise-induced cardioprotection. The potential role of CSM in exercise-induced cardioprotection will be approached from two perspectives. First, endurance exercise training effects on the regulation of coronary vasomotor tone via changes in CSM calcium regulation will be reviewed, i.e. short-term functional adaptation. Secondly, we will discuss potential long-term consequences of this altered calcium regulation, i.e. exercise-induced phenotypic modulation of CSM. We propose that exercise training alters CSM intracellular calcium regulation to reduce Ca2+-dependent activation of the contractile apparatus and Ca2+-dependent gene transcription and increase activation of sarcolemmal potassium channels. The overall effect is to increase the gain of the vasomotor system and maintain a stable, contractile CSM phenotype.
authors.affiliation: Department of Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA.
authors.forename: D K
authors.initials: DK
authors.lastname: Bowles
authors.forename: B R
authors.initials: BR
authors.lastname: Wamhoff
mesh_terms: D000222:Adaptation, Physiological; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology / Q000517:prevention & control*; D003331:Coronary Vessels / Q000503:physiopathology; D016232:Endothelins / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D008833:Microcirculation / Q000503:physiopathology; D008934:Mitogens / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000502:physiology; D009206:Myocardium / Q000378:metabolism; D010641:Phenotype; D015221:Potassium Channels / Q000378:metabolism; D014662:Vasoconstrictor Agents / Q000378:metabolism; D014666:Vasomotor System / Q000503:physiopathology
chemical_list: D015220:Calcium Channels; D016232:Endothelins; D008934:Mitogens; D015221:Potassium Channels; D014662:Vasoconstrictor Agents; D002118:Calcium