Glutathione metabolism and antioxidant enzymes in children with Down syndrome.
Oxidative stress has been proposed as a pathogenic mechanism of atherosclerosis, cell aging, and neurologic disorders in Down syndrome. This study demonstrates a systemic decrease of all glutathione forms, including glutathionyl-hemoglobin, in the blood of children with Down syndrome. Furthermore, we obtained a disequilibrium, in vivo, between the antioxidant enzyme activities.
Pastore
Anna
A
Laboratory of Biochemistry, Molecular Medicine Unit, Children's Hospital and Research Institute Bambino Gesù, Rome, Italy.
Tozzi
Giulia
G
Gaeta
Laura Maria
LM
Giannotti
Aldo
A
Bertini
Enrico
E
Federici
Giorgio
G
Digilio
Maria Cristina
MC
Piemonte
Fiorella
F
D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D004314:Down Syndrome / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D008297:Male; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism*
D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione