title: Non-invasive exclusion and diagnosis of pulmonary embolism by sequential use of the rapid ELISA D-dimer assay, clinical score and spiral CT.
abstract: Pulmonary angiography is the gold standard for segmental pulmonary embolism (PE) but no longer for its subsegmental PE, because the inter-observer agreement for angiographically documented subsegmental PE is only 60%. Two non-invasive tools exclude PE with a negative predictive value of > 99%: a normal perfusion lung scan and a normal rapid ELISA VIDAS D-dimer test. The positive predictive value of a high probability ventilation-perfusion lung scan (VP-scan) is only 85% to 87%. The combination of a low clinical score and a non-diagnostic VP-scan safely exclude PE without the need of angiography. The prevalence of PE and that of an alternative diagnosis in symptomatic patients with a non-diagnostic VP-scan are 10% to 20% and 30% to 45%, respectively. Helical spiral computed tomography (CT) detects all clinically relevant PE and a large number of alternative diagnoses in symptomatic patients with a non-diagnostic or high probability VP-scan. The positive predictive value of the spiral CT is > 95%. Single-slice helical CT as the primary diagnostic test in patients with suspected PE in retrospective outcome studies and in prospective multicenter management studies indicate that the negative predictive value of a negative spiral CT preceded or followed by a negative compression ultrasonography (CUS) is > 99%. Therefore, a helical spiral CT can replace both the VP-scan and pulmonary angiography to safely rule in and out PE. A negative rapid ELISA VIDAS D-dimer test result will reduce the need for helical spiral CT by 25% to 35%.
authors.affiliation: Hemostasis Thrombosis Research, Department of Hematology, University Hospital, Antwerp, Belgium. postbus@goodheartcenter.demon.nl
authors.forename: J J
authors.initials: JJ
authors.lastname: Michiels
authors.forename: W
authors.initials: W
authors.lastname: Schroyens
authors.forename: W
authors.initials: W
authors.lastname: De Backer
authors.forename: M
authors.initials: M
authors.lastname: van der Planken
authors.forename: H
authors.initials: H
authors.lastname: Hoogsteden
authors.forename: P M T
authors.initials: PM
authors.lastname: Pattynama
mesh_terms: D000368:Aged; D000792:Angiography; D004797:Enzyme-Linked Immunosorbent Assay; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D036542:Tomography, Spiral Computed; D020246:Venous Thrombosis / Q000453:epidemiology; D014692:Ventilation-Perfusion Ratio
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D