title: African swine fever and classical swine fever: a review of the pathogenesis.
abstract: This paper describes major pathogenetic mechanisms of African and Classical Swine Fever virus infections. The interactions between both viruses and the monocyte-macrophage-system result in the release of mediator molecules, which are important for the further progression of the diseases. The causes of the thrombocytopenia and the mechanisms of the haemorrhages, which are characteristic in both infections, are described. Apoptotic cell death is regarded as the predominant cause of lymphopenia in both virus infections.
authors.affiliation: Dpto. Anatomía, Patológica, Facultad de Veterinaria, Córdoba, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Gómez-Villamandos
authors.forename: L
authors.initials: L
authors.lastname: Carrasco
authors.forename: M J
authors.initials: MJ
authors.lastname: Bautista
authors.forename: M A
authors.initials: MA
authors.lastname: Sierra
authors.forename: M
authors.initials: M
authors.lastname: Quezada
authors.forename: J
authors.initials: J
authors.lastname: Hervas
authors.forename: M de Lara F
authors.initials: Mde L
authors.lastname: Chacón
authors.forename: E
authors.initials: E
authors.lastname: Ruiz-Villamor
authors.forename: F J
authors.initials: FJ
authors.lastname: Salguero
authors.forename: P J
authors.initials: PJ
authors.lastname: Sónchez-Cordón
authors.forename: S
authors.initials: S
authors.lastname: Romanini
authors.forename: A
authors.initials: A
authors.lastname: Núñez
authors.forename: T
authors.initials: T
authors.lastname: Mekonen
authors.forename: A
authors.initials: A
authors.lastname: Méndez
authors.forename: A
authors.initials: A
authors.lastname: Jover
mesh_terms: D000357:African Swine Fever / Q000209:etiology / Q000821:virology*; D000358:African Swine Fever Virus / Q000472:pathogenicity*; D000818:Animals; D017209:Apoptosis; D006691:Classical Swine Fever / Q000209:etiology / Q000821:virology*; D006692:Classical Swine Fever Virus / Q000472:pathogenicity*; D016207:Cytokines / Q000378:metabolism; D008264:Macrophages / Q000276:immunology / Q000821:virology*; D009000:Monocytes / Q000276:immunology / Q000821:virology*; D013552:Swine
chemical_list: D016207:Cytokines