title: A gene for familial isolated chronic nail candidiasis maps to chromosome 11p12-q12.1.
abstract: Chronic mucocutaneous candidiases (CMC) are a group of rare disorders where an altered immune response against Candida leads to persistent and/or recurrent infections of the skin, nails, and mucous membranes. We analysed a five-generation Italian family with an isolated form of CMC, affecting nails only, in the presence of low serum concentration of intercellular adhesion molecule I (ICAM-1). We excluded linkage to candidate regions on chromosomes 2p (CMC with thyroid disease), 21q22.3 (APECED), and 19q13 (ICAM-1). We then carried out a genome-wide scan and assigned the CMC locus to a 19 cM pericentromeric region on chromosome 11.
authors.affiliation: 1IRCCS-CSS San Giovanni Rotondo, CSS-Mendel, Rome, Italy. m.mangino@css-mendel.it
authors.forename: M
authors.initials: M
authors.lastname: Mangino
authors.forename: D C
authors.initials: DC
authors.lastname: Salpietro
authors.forename: D
authors.initials: D
authors.lastname: Zuccarello
authors.forename: S
authors.initials: S
authors.lastname: Gangemi
authors.forename: L
authors.initials: L
authors.lastname: Rigoli
authors.forename: M V
authors.initials: MV
authors.lastname: Merlino
authors.forename: S
authors.initials: S
authors.lastname: Briuglia
authors.forename: G
authors.initials: G
authors.lastname: Bisignano
authors.forename: R
authors.initials: R
authors.lastname: Mingarelli
authors.forename: B
authors.initials: B
authors.lastname: Dallapiccola
mesh_terms: D002178:Candidiasis, Chronic Mucocutaneous / Q000235:genetics*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics; D007558:Italy; D010375:Pedigree
chemical_list: D018799:Intercellular Adhesion Molecule-1