title: The effect of cyclodextrins on the in vitro and in vivo properties of insulin-loaded poly (D,L-lactic-co-glycolic acid) microspheres.
abstract: In this work we describe the development and characterization of a new formulation of insulin (INS). Insulin was complexed with cyclodextrins (CD) in order to improve its solubility and stability being available as a dry powder, after encapsulation into poly (D,L-lactic-co-glycolic acid) (PLGA) microspheres. The complex INS : CD was encapsulated into microspheres in order to obtain particles with an average diameter between 2 and 6 microm. This system was able to induce significant reduction of the plasma glucose level in two rodent models, normal mice and diabetic rats, after intratracheal administration.
authors.affiliation: Laboratory of Pharmaceutical Technology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. jmrj@rdbiotec.com.br
authors.forename: José Maciel
authors.initials: JM
authors.lastname: Rodrigues Júnior
authors.forename: Karla
authors.initials: K
authors.lastname: de Melo Lima
authors.forename: Carlos Eduardo
authors.initials: CE
authors.lastname: de Matos Jensen
authors.forename: Marta Maria Gontijo
authors.initials: MM
authors.lastname: de Aguiar
authors.forename: Armando
authors.initials: A
authors.lastname: da Silva Cunha Júnior
mesh_terms: D000818:Animals; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers; D066298:In Vitro Techniques; D007328:Insulin / Q000008:administration & dosage / Q000138:chemical synthesis*; D019344:Lactic Acid / Q000737:chemistry*; D008297:Male; D051379:Mice; D008863:Microspheres; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D011208:Powders; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003505:Cyclodextrins; D004337:Drug Carriers; D007328:Insulin; D011108:Polymers; D011208:Powders; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid