title: [Local application of bFGF and sucralfate during continuous tissue expansion].
abstract: OBJECTIVE
  To investigate the effect of local application of bFGF and sucralfate during continuous tissue expansion (CTE).
  
  
  METHODS
  CTE combined with local administration of bFGF and sucralfate was used in twelve patients with scar and nasal tip defects. Twenty three expanders were placed in the subcutaneous pockets through intralesion short incisions. Continuous expansion began at 1-3 days after expander implantation. The histomorphological changes and epidermal cell proliferation were observed. The clinical results were investigated.
  
  
  RESULTS
  The average inflation time was 8.9 days. The average interval of the two operations was 13.5 days. The average hospitalization was 28.4 days. The average immediate stretch-back rate of the expanded skin was 25.7%. The clinical results were satisfactory without any complications. Histological examinations showed that the epidermal, granular and spinous layer became thicker. The basal cells increased significantly. The dermis thinned slightly and the collagen fibers became thicker. The elastic fiber regenerated significantly. Fibroblast and capillary density increased obviously. The immunohistochemistry analysis showed that the proliferation of epidemic basal cells was significant postoperatively.
  
  
  CONCLUSIONS
  Local application of exogenous bFGF and sucralfate during CTE was feasible in patients. It could accelerate tissue expansion and improve the quality of expanded skin flap.
authors.affiliation: Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Ya-lan
authors.initials: YL
authors.lastname: Hu
authors.forename: Shu-zhong
authors.initials: SZ
authors.lastname: Guo
authors.forename: Kai-hua
authors.initials: KH
authors.lastname: Lu
authors.forename: Yan
authors.initials: Y
authors.lastname: Han
authors.forename: Yong-hong
authors.initials: YH
authors.lastname: Lei
authors.forename: Bao-qiang
authors.initials: BQ
authors.lastname: Song
authors.forename: Yong
authors.initials: Y
authors.lastname: Pan
mesh_terms: D002196:Capillaries / Q000033:anatomy & histology; D049109:Cell Proliferation; D003094:Collagen / Q000032:analysis; D020405:Dermis / Q000098:blood supply / Q000473:pathology; D000078404:Epidermal Cells; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D007902:Length of Stay; D009667:Nose Deformities, Acquired / Q000601:surgery*; D013392:Sucralfate / Q000494:pharmacology*; D013524:Surgical Flaps / Q000098:blood supply; D013997:Time Factors; D015626:Tissue Expansion / Q000295:instrumentation / Q000379:methods*; D015625:Tissue Expansion Devices; D016896:Treatment Outcome
chemical_list: D013392:Sucralfate; D005346:Fibroblast Growth Factors; D003094:Collagen