title: After-cataract in adults with primary posterior capsulorhexis: comparison of hydrogel and silicone intraocular lenses with round edges after 2 years.
abstract: OBJECTIVE
  To evaluate the potential of primary posterior continuous curvilinear capsulorhexis (PCCC) to prevent after-cataract 2 years after surgery and perform a bilateral comparison of 2 intraocular lens (IOL) materials, silicone and hydrogel.
  
  
  METHODS
  Department of Ophthalmology, University of Vienna, Medical School, Vienna, Austria.
  
  
  METHODS
  In this randomized patient- and examiner-masked study, 37 patients (74 eyes) with age-related cataract had bilateral small-incision cataract surgery with PCCC. Randomly, 1 eye received a hydrogel IOL and the contralateral eye, a silicone IOL. Both IOLs had open-loop haptics and a round-edged optic. Standardized digital retroillumination photographs were taken 1 day and 1, 6, 12, and 24 months after surgery to evaluate development of after-cataract on the anterior and posterior capsules by subjective grading. Opacification of the PCCC area was also objectively evaluated using new software.
  
  
  RESULTS
  Twenty-nine patients (58 eyes) completed the 2-year follow-up. Partial closure with ongrowth at the edge of the PCCC was found in 55% in the hydrogel group and 28% in the silicone group. Total closure of the PCCC was observed in 3 eyes, 2 in the hydrogel group and 1 in the silicone group.
  
  
  CONCLUSIONS
  Ongrowth onto the PCCC area was dependent on IOL material. Because of less ongrowth and more fibrotic after-cataract with silicone IOLs, the efficacy of the PCCC was higher in this group.
authors.affiliation: Department of Ophthalmology, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. michael.georgopoulos@akh-wien.ac.at
authors.forename: Michael
authors.initials: M
authors.lastname: Georgopoulos
authors.forename: Rupert
authors.initials: R
authors.lastname: Menapace
authors.forename: Oliver
authors.initials: O
authors.lastname: Findl
authors.forename: Vanessa
authors.initials: V
authors.lastname: Petternel
authors.forename: Barbara
authors.initials: B
authors.lastname: Kiss
authors.forename: Georg
authors.initials: G
authors.lastname: Rainer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019923:Capsulorhexis / Q000379:methods; D002386:Cataract / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D004311:Double-Blind Method; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D053685:Laser Therapy; D007903:Lens Capsule, Crystalline / Q000473:pathology* / Q000601:surgery; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D011474:Prosthesis Design; D012826:Silicone Elastomers
chemical_list: D012826:Silicone Elastomers; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate