title: Prognosis of patients with unstable angina and low-risk exercise test: significance of ST-segment depression on the admission ECG.
abstract: The presence of ST-segment depression on the admission electrocardiogram (ECG) is an important predictor of poor outcome in patients with unstable angina. On the other hand, patients with unstable angina who undergo a low-risk exercise test are supposed to have a favorable prognosis. The objective of the study was to determine the prognostic significance of ST-segment depression on the admission ECG in patients with unstable angina who undergo an exercise test that indicates a low risk of events. An interpretable exercise test was performed in 257 patients with primary unstable angina. A low-risk exercise test was completed by 156 (60%) patients and medical therapy was planned for all these patients. A multivariate analysis was performed in order to determine the independent predictors of events (cardiac death, nonfatal acute myocardial infarction, or admission for unstable angina) during a 12-month follow-up. Among patients with a low-risk exercise test, there were no significant differences between patients with and without ST-segment depression on the presenting ECG with regard to event rate (34 vs. 29%, P=NS). In multivariate analysis, ST-segment depression was not related to a higher incidence of events. Our findings appear to indicate that the presence of ST-segment depression on the admission ECG loses its prognostic significance in patients with primary unstable angina if they complete a low-risk exercise test.
authors.affiliation: Cardiology Unit, Hospital Santa Mari;a del Rosell, Avenida Reina Victoria, 28-A, 6 degrees I, 30204, Cartagena, Spain. jacastillomo@hotmail.com <jacastillomo@hotmail.com>
authors.forename: Juan A
authors.initials: JA
authors.lastname: Castillo-Moreno
authors.forename: Eduardo
authors.initials: E
authors.lastname: Molina-Laborda
authors.forename: Rafael
authors.initials: R
authors.lastname: Florenciano-Sánchez
authors.forename: José G
authors.initials: JG
authors.lastname: Villanueva-Sánchez
authors.forename: Santiago
authors.initials: S
authors.lastname: Egea-Beneyto
authors.forename: Juan
authors.initials: J
authors.lastname: Ortega-Bernal
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000175:diagnosis*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011237:Predictive Value of Tests; D011379:Prognosis