[Dopamine beta hydroxylase gene polymorphism and Parkinson's disease].
OBJECTIVE
To investigate the correlation between the polymorphism of dopamine beta hydroxylase(DBH) gene and the susceptibility of Shanghai Chinese Han population to Parkinson's disease(PD).


METHODS
Association study was performed in 144 PD patients and 188 healthy control subjects matched for age, sex and origin. Polymorphism of DBH gene was analyzed with polymerase chain reaction-restriction fragment length polymorphism.


RESULTS
The allelic frequency of A2 allele of DBH gene was significantly higher in PD patients than in controls(P<0.01).The risk of suffering from PD increased (OR=1.82) in the individual with A2 allele. And the genotypic frequency of A2/A2 was significantly higher in PD patients(OR=2.11, P<0.01),too. On the other hand, the allelic frequency of A1 allele and the genotypic frequency of A1/A2 genotype of DBH gene in PD patients were significantly lower(A1 alleles: OR=0.54, P<0.01; A1/A2 genotypes: OR=0.45, P<0.01).


CONCLUSIONS
The polymorphism in DBH gene might play an important role in the susceptibility of Shanghai Chinese Han population to PD.
Zhao
Xiao-ping
XP
Department of Neurology, Changhai Hospital, the Second Military Medical University, Shanghai, 200433 PR China. xiaopingzhao1@263.ne
Xie
Hui-jun
HJ
Tang
Guo-mei
GM
Zhao
Wu-wei
WW
Xu
Ling
L
Su
Jing-jing
JJ
Hao
Yi-xin
YX
Ren
Da-ming
DM
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002681:China; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D004299:Dopamine beta-Hydroxylase