title: The early tissue response to titanium and LactoSorb screws.
abstract: Fractures of the maxillofacial region are common in the elderly people. Titanium and LactoSorb screws are the widely accepted materials for use in the maxillofacial fractures. This study was undertaken to evaluate the early tissue response following the insertion of both titanium and LactoSorb screws composed of 82% PLLA and 18% PGA in an elderly animal model. In this study, 22 titanium and 22 LactoSorb screws were applied to calvaria of 44 guinea pigs that were 10-11 months old. Animals were sacrificed on postoperative days 3, 7, 14, 30 and 60. Screws were retrieved with surrounding bone tissue and the specimens were prepared for routine histologic examination. All the specimens were evaluated by light microscopy. Histometric analysis revealed that there was no significant difference between LactoSorb and titanium screws for the new bone formation. The biodegradation of LactoSorb screws was not complete by the end of day 60. In conclusion, both materials were well tolerated and induced bone formation without causing adverse tissue response in an elderly animal model. Our results suggest that both LactoSorb and titanium miniplates and screws can be used safely, regardless of the increasing age. However, LactoSorb may be the first choice as it does not require a second operation for removal and has late biodegradation in elderly that keeps its support for a relatively longer time during fracture healing.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey. nmollaoglu@hotmail.com
authors.forename: Nur
authors.initials: N
authors.lastname: Mollaoglu
authors.forename: Sedat
authors.initials: S
authors.lastname: Cetiner
authors.forename: Cansu
authors.initials: C
authors.lastname: Alpaslan
authors.forename: Sibel Elif
authors.initials: SE
authors.lastname: Gültekin
authors.forename: Reha
authors.initials: R
authors.lastname: Alpar
mesh_terms: D020341:Absorbable Implants; D000367:Age Factors; D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D001863:Bone Screws; D003238:Connective Tissue / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D019344:Lactic Acid / Q000633:toxicity*; D010012:Osteogenesis / Q000187:drug effects; D011100:Polyglycolic Acid / Q000633:toxicity*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000633:toxicity*; D012886:Skull / Q000187:drug effects; D014025:Titanium / Q000633:toxicity
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D014025:Titanium