[Tibolone therapy in postmenopausal women with a history of many risk factors].
BACKGROUND
The changes of the indications and the use of hormone replacement therapy have entered into the focus of interest.


OBJECTIVE
The author studied whether hormone replacement therapy can be used in postmenopausal patients with high risk factors in their history (thromboembolic disorders, diabetes mellitus, hypertension, stroke, cardiovascular disease, pulmonary embolism).


METHODS
Tibolone 2.5 mg daily was prescribed. Data of 124 patients with the above conditions were analized at the beginning and at 12, 24, 36 months follow-up visits. The frequency of exacerbation of the anamnestic risk factors, menopausal complaints, laboratory tests and instrumental tests (transvaginal sonography, mammography, bone densitometry), as well as efficacy and side effects of the therapy were studied.


RESULTS
During the 36-months follow up tibolone therapy effectively reduced menopausal complaints, caused no increase in the anamnestic risk factors, or serious side effects and did not worsened the results of the laboratory tests.


CONCLUSIONS
In the author's opinion hormone replacement therapy with tibolone can be safely performed in patients with high risk factors in the history.
Szántó
Ferenc
F
Szeged Városi Rendelóintézet, Klimax Ambulancia.
D002318:Cardiovascular Diseases / Q000150:complications*; D048909:Diabetes Complications; D020847:Estrogen Receptor Modulators / Q000008:administration & dosage* / Q000009:adverse effects; D015914:Estrogen Replacement Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008875:Middle Aged; D009652:Norpregnenes / Q000008:administration & dosage* / Q000009:adverse effects; D017698:Postmenopause; D012307:Risk Factors; D020521:Stroke / Q000150:complications; D013923:Thromboembolism / Q000150:complications
D020847:Estrogen Receptor Modulators; D009652:Norpregnenes; C027385:tibolone