title: Low-resolution molecular replacement using a six-dimensional search.
abstract: A parallel-aware program MPI_FSEARCH has been implemented to perform molecular replacement using an exhaustive six-dimensional search. In particular, the program can be used to deal with diffraction data at very low resolution (d > 10 A) that would normally not be appropriate for other molecular-replacement programs such as AMoRe and CNS. Although an envelope constructed from a PDB (Protein Data Bank) file was tested in the present study, the program can be used to perform low-resolution molecular replacement with an envelope derived from various sources such as electron microscopy or small-angle solution X-ray scattering.
authors.affiliation: MacCHESS at Cornell High Energy Synchrotron Source, Cornell University, Ithaca, NY 14853-8001, USA.
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Weaver
authors.forename: Tao
authors.initials: T
authors.lastname: Xiang
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Thiel
authors.forename: Quan
authors.initials: Q
authors.lastname: Hao
mesh_terms: D010832:6-Phytase / Q000737:chemistry; D001232:Aspergillus fumigatus / Q000201:enzymology; D003198:Computer Simulation; D018360:Crystallography, X-Ray / Q000379:methods*; D008958:Models, Molecular; D008968:Molecular Conformation; D011506:Proteins / Q000737:chemistry*; D012984:Software
chemical_list: D011506:Proteins; D010832:6-Phytase