title: Synthesis of ibuprofen heterocyclic amides and investigation of their analgesic and toxicological properties.
abstract: A series of amides of ibuprofen with heteroaromatic amines was synthesized and assayed in vivo for their analgesic properties by means of writhing test in rats. When compared to parent ibuprofen some of the new amides exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect.
authors.affiliation: Dipartimento di Tossicologia, Università degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy. tcocco@unica.it
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Cocco
authors.forename: Cenzo
authors.initials: C
authors.lastname: Congiu
authors.forename: Valentina
authors.initials: V
authors.lastname: Onnis
authors.forename: Micaela
authors.initials: M
authors.lastname: Morelli
authors.forename: Omar
authors.initials: O
authors.lastname: Cauli
mesh_terms: D019342:Acetic Acid / Q000037:antagonists & inhibitors / Q000633:toxicity; D000284:Administration, Oral; D000577:Amides / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000737:chemistry* / Q000633:toxicity*; D000818:Animals; D007052:Ibuprofen / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D007274:Injections, Intraperitoneal; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010146:Pain / Q000139:chemically induced; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D011726:Pyridinium Compounds / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013055:Spectrophotometry, Infrared; D013276:Stomach Ulcer / Q000517:prevention & control; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D018712:Analgesics, Non-Narcotic; D011726:Pyridinium Compounds; D019342:Acetic Acid; D007052:Ibuprofen