title: Scanning electron microscopy and atomic force microscopy imaging of solid lipid nanoparticles derived from amphiphilic cyclodextrins.
abstract: Scanning electron microscopy (SEM) and atomic force microscopy (AFM) have been applied to the imagery of solid lipid nanoparticles (SLNs) formulated from an amphiphilic cyclodextrin, 2,3-di-o-alkanoyl-beta-cyclodextrin, beta-CD21C6. Comparison of the results shows that the vacuum drying technique used in sample preparation for SEM causes shrinkage in the size of the SLNs, whereas the deposition method used for AFM causes the SLNs to form small clusters. The hydrodynamic diameter determined from photon correlation spectroscopy (PCS) is 359+/-15 nm and the zeta potential is -25 mV.
authors.affiliation: Synthèse, Reconnaissance, Organisation Moléculaire et Biomoléculaire (SROMB), CNRS UMR 5078 Université Claude Bernard Lyon1, Cedex, Villeurbanne, France.
authors.forename: Alix
authors.initials: A
authors.lastname: Dubes
authors.forename: Hélène
authors.initials: H
authors.lastname: Parrot-Lopez
authors.forename: Wassim
authors.initials: W
authors.lastname: Abdelwahed
authors.forename: Ghania
authors.initials: G
authors.lastname: Degobert
authors.forename: Hatem
authors.initials: H
authors.lastname: Fessi
authors.forename: Patrick
authors.initials: P
authors.lastname: Shahgaldian
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Coleman
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D018625:Microscopy, Atomic Force / Q000379:methods; D008855:Microscopy, Electron, Scanning / Q000379:methods; D036103:Nanotechnology / Q000379:methods*; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D003505:Cyclodextrins; D008055:Lipids; D013501:Surface-Active Agents