Zopiclone-induced acute interstitial nephritis.
Zopiclone, a relatively new nonbenzodiazepine short-acting hypnotic medication is prescribed frequently for insomnia. The authors report a case of zopiclone-induced acute interstitial nephritis in a young, otherwise healthy man. The patient presented with anuric acute renal failure requiring hemodialysis. Kidney biopsy results showed acute interstitial nephritis with a prominent eosinophilic infiltrate in the interstitium. He recovered his renal function after stopping the medication and receiving corticosteroids.
Hussain
Naser
N
Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
MacKinnon
Martin
M
Akbari
Ayub
A
D000208:Acute Disease; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000293:Adolescent; D053961:Azabicyclo Compounds; D001706:Biopsy; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D007668:Kidney / Q000473:pathology; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology; D010879:Piperazines / Q000009:adverse effects*
D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone