title: [Contralateral suppression of latency during distortion product otoacoustic emissions detection in guinea pigs].
abstract: OBJECTIVE
  To investigate the cochlear micromechanics and the function of cochlear efferent system by detecting the distortion product otoacoustic emissions (DPOAE) with or without contralateral acoustic stimulation.
  
  
  METHODS
  The DPOAE amplitude and latency of the cubic DPOAE (2f1-f2) were measured at f2 = 2, 4 and 6 kHz with or without 70 dB SPL broad-band noise contralateral stimulation in ears of 12 healthy pigmented guinea pigs, which were divided into two groups(A and B) and tested with different primary intensity level combinations. On the next day, an operation was made to open the acoustic bulla of right ear in Group A. Kainic Acid (KA, 1 microL of 60 mmol/L) was applied onto the round window membrane and wiped up carefully after three hours. The amplitude and latency of the cubic DPOAE from the left ear were measured after 6 hours of KA administration, with or without contralateral noise stimulation.
  
  
  RESULTS
  Before the KA treatment, the amplitude of DPOAE induced by primaries of equal levels (L1 = L2) presented no significant change and the latency prolonged significantly during contralateral acoustic stimulation (Group A). But the amplitude at 2, 4 kHz of DPOAE induced by primaries of different levels (L1 > L2) decreased significantly and the latency also prolonged significantly (Group B). After KA administration in the contralateral ear of Group A, the contralateral acoustic stimulation had no significant effect on either amplitude or latency of DPOAE measured ipsilaterally.
  
  
  CONCLUSIONS
  The result demonstrates that the latency is a sensitive index for the cochlear contralateral suppression. The efferent system may act as a negative feedback during the cochlear transduction.
authors.affiliation: Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. weijiak@public.wh.hb.cn
authors.forename: W
authors.initials: W
authors.lastname: Kong
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: W
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001301:Audiometry, Pure-Tone; D003051:Cochlea / Q000293:injuries / Q000502:physiology*; D004525:Efferent Pathways / Q000502:physiology; D005260:Female; D006168:Guinea Pigs; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D010469:Perceptual Distortion; D011930:Reaction Time / Q000502:physiology