Multicentre Italian family-based association study on tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders.
OBJECTIVE
The aim of the present study was to investigate tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 genes in mood disorders using a family-based association approach.


METHODS
The sample included 134 nuclear mood disorder families, with subjects affected by bipolar disorder (n=103) or major depressive disorder (n=58). All subjects were genotyped using polymerase chain reaction techniques.


RESULTS
No significant transmission disequilibrium was found in the overall sample for any polymorphism. Analysis considering bipolar subjects only, or psychopathology traits as affection status did not influence the observed results.


CONCLUSIONS
The study could not support the involvement of tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders.
Serretti
Alessandro
A
Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy.
Cusin
Cristina
C
Cristina
Silvano
S
Lorenzi
Cristina
C
Lilli
Roberta
R
Lattuada
Enrico
E
Grieco
Gaetano
G
Costa
Alfredo
A
Santorelli
Filippo
F
Barale
Francesco
F
Smeraldi
Enrico
E
Nappi
Giuseppe
G
D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22; D005190:Family; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007558:Italy; D015810:Linkage Disequilibrium; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D019964:Mood Disorders / Q000201:enzymology / Q000235:genetics*; D011110:Polymorphism, Genetic; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*; D044465:White People / Q000235:genetics; D014929:Wolfram Syndrome / Q000235:genetics
D008565:Membrane Proteins; C114987:wolframin protein; D014446:Tyrosine 3-Monooxygenase; D002394:Catechol O-Methyltransferase