Pancreatic Polypeptide Secretion in Patients with Chronic Pancreatitis and After Pancreatic Surgery.
Pancreatic polypeptide (PP) is a 36-amino acidpolypeptide with a molecular weight of 4200 (1). PP is mainly produced in the head of the pancreas in adistinct cell type both within the islets and scatteredamong the exocrine parenchyma (2,3). PP release isunder neural and hormonal control. Ingestion of nutrients,cholinergic neural activation and infusion ofgastro-intestinal peptides (especially CCK) stimulatePP release (1,4,5). It has been clearly shown that PPsecretion is under vagal cholinergic control since thePP response to a meal or CCK infusion is bluntedduring vagal cholinergic blockade with atropine orfollowing truncal vagotomy (1,6).
Eddes
Eric
E
Department of General Surgery, Leiden University Medical Center, The Netherlands.
Verkijk
Marco
M
Gielkens
Hugo
H
Biemond
Izak
I
Bemelman
Willem
W
Lamers
Cornelis
C
Masclee
Ad
A