title: Pylorus preservation after complete gastrectomy and jejunal interposition: experimental study investigating motility and alkaline reflux.
abstract: BACKGROUND
  Pylorus preservation has been proposed to reduce the disturbance in gastric emptying following gastrectomy but little is known about the role of the pylorus regarding motility patterns and alkaline reflux.
  
  
  OBJECTIVE
  To assess the motility patterns and alkaline reflux following pylorus preservation after complete gastrectomy and jejunal interposition in the pig.
  
  
  METHODS
  Motility patterns and alkaline reflux were studied in 12 conscious pigs before and after gastrectomy and jejunal interposition with preservation of the pylorus and a 1 cm antral ring (PYL+) or excised pylorus (PYL-) 6 and 14 weeks postoperatively. Gastroduodenal motility was investigated by manometry after fasting and fed, respectively and alkaline reflux by a fiberoptic system for detecting bilirubin.
  
  
  RESULTS
  The number of propagated phase-III activities of the jejunal interponat to the duodenum and propagating velocity were lower in the PYL+ group after 6 weeks (p < 0.05) but higher after 14 weeks (p < 0.05) compared to the PYL- group. In the PYL+ the number of intrapyloric pressure waves (IPPWs) was lower after 6 weeks (p < 0.05) but higher after 14 weeks (p < 0.05) in comparison to preoperative controls. Alkaline reflux was significantly higher in the PYL- group than in the PYL+ group throughout the time observed.
  
  
  CONCLUSIONS
  Pyloric function shows a delay after 6 weeks but restores within 14 weeks postoperatively. Pylorus preservation was associated with a significant decrease of alkaline reflux compared to PYL- in this setting.
authors.affiliation: Department of Surgery, Charité Humboldt University of Berlin, Schumannstreet 20/21, D-10117 Berlin, Germany. zierencharite@hotbot.com
authors.forename: J
authors.initials: J
authors.lastname: Zieren
authors.forename: M
authors.initials: M
authors.lastname: Karaus
authors.forename: F A
authors.initials: FA
authors.lastname: Wenger
authors.forename: J M
authors.initials: JM
authors.lastname: Müller
mesh_terms: D000818:Animals; D004383:Duodenogastric Reflux / Q000209:etiology / Q000503:physiopathology*; D004386:Duodenum / Q000503:physiopathology / Q000601:surgery; D005743:Gastrectomy / Q000009:adverse effects*; D005746:Gastric Emptying; D005769:Gastrointestinal Motility; D007583:Jejunum / Q000503:physiopathology / Q000637:transplantation*; D008365:Manometry; D011708:Pylorus / Q000601:surgery; D013552:Swine