Mechanisms and methods to resolve edge effect.
Vascular brachytherapy (VBT) has established itself as a viable modality to treat in-stent restenosis (ISR). The problems associated with VBT have been understood well and remedied. Late thrombosis has been overcome to a great extent by prolonged antiplatelet therapy. Edge effect is another important limitation of VBT and is due to inadequate radiation coverage of the edges following VBT. It may be overcome by confining injury to the lesion segment and extending the radiation sources by a few millimeters from the injured segment.
Kuchulakanti
Pramod
P
Division of Cardiology, Washington Hospital Center, Washington, DC 20010, USA. ron.waksman@medstar.ne
Lew
Robert
R
Waksman
Ron
R
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation* / Q000379:methods; D000818:Animals; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D002986:Clinical Trials as Topic; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000628:therapy; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011829:Radiation Dosage; D011859:Radiography; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D015607:Stents / Q000009:adverse effects*; D013552:Swine; D016896:Treatment Outcome