Pre and postnatal exposure to endosulfan in Wistar rats.
The possible reproductive adverse effects of the pesticide endosulfan on male offspring rats exposed in utero and during lactation were investigated. Dams were treated orally with 0, 0.5 or 1.5 mg of endosulfan/kg 21 days prior to mating, during the mating, pregnancy and lactation. Maternal and reproductive outcome data and male sexual development landmarks (testis descent and preputial separation) were assessed. Reproductive endpoints of the male offspring were examined at adulthood: sex organ weights, daily sperm production, spermatid number, sperm transit, sperm morphology and testosterone level. No signs of maternal toxicity were detected at the dose levels tested. Sexual development landmarks were also unaffected. Moreover, with the exception of a significant increase in the relative epididymis weight seen in the group treated with the lowest dose, we have not found any statistically significant adverse effect in the reproductive endpoints investigated at adulthood. The results of the present study indicate that pre and postnatal exposure to low doses of endosulfan (0.5 and 1.5 mg/kg) do not induce significant adverse effects in the reproductive system of male offspring Wistar rats at adulthood.
Dalsenter
Paulo R
PR
Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil. pdalsenter@ufpr.br
de Araújo
Samanta L
SL
de Assis
Helena C da Silva
HC
Andrade
Anderson J M
AJ
Dallegrave
Eliane
E
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D004726:Endosulfan / Q000633:toxicity*; D004822:Epididymis / Q000033:anatomy & histology / Q000187:drug effects; D005260:Female; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000633:toxicity*; D007774:Lactation; D008297:Male; D023421:Models, Animal; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011256:Pregnancy Outcome; D011297:Prenatal Exposure Delayed Effects; D011467:Prostate / Q000033:anatomy & histology / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects; D012669:Seminal Vesicles / Q000033:anatomy & histology / Q000187:drug effects; D013076:Sperm Count; D013094:Spermatozoa / Q000166:cytology* / Q000187:drug effects; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects; D013739:Testosterone / Q000097:blood
D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D013739:Testosterone; D004726:Endosulfan