[Polymorphism of two novel SNPs, which locate on chromosome 9p21-22, in Han Chinese of Hunan].
OBJECTIVE
To search novel SNPs in exons and regulatory regions of CDKN2A and two novel putative tumor suppressor genes NGX6 and UBAP1, which all reside on chromosome 9p21-22.


METHODS
The exons and regulatory regions of those genes were amplified and sequenced in 96 subjects.


RESULTS
Two novel SNPs were found, one resides on the sixth exon of UBAP1 gene and the other on the fourth exon of CDKN2A gene. Two novel SNPs were submitted to the dbSNP database, and their access ID are rs3135929 and rs3088440. The polymorphic information contents of them are 0.102 and 0.213 respectively. There is linkage equilibrium between them, and the polymorphic information content of their haplotype is 0.302, higher than any of them individually.


CONCLUSIONS
The polymorphic information content can be improved by using haplotype analysis of several SNPs.
Xiong
Wei
W
Cancer Research Institute, Xiangya Medical School, Hunan, PR China.
Zeng
Zhao-yang
ZY
Shen
Shou-rong
SR
Li
Xiao-ling
XL
Lu
Hong-bin
HB
Xiang
Juan-juan
JJ
Nie
Xin-min
XM
Zhu
Shi-guo
SG
Li
Wei-fang
WF
Wang
Rong
R
He
Lin
L
Li
Gui-yuan
GY
D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002681:China / Q000208:ethnology; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D019942:Genes, p16 / Q000502:physiology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D025521:Tumor Suppressor Proteins / Q000235:genetics*
D002352:Carrier Proteins; D008565:Membrane Proteins; C477325:TMEM8B protein, human; D025521:Tumor Suppressor Proteins; C469867:UBAP1 protein, human