Rocks: multifunctional kinases in cell behaviour.
ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states.
Riento
Kirsi
K
Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK. kirsi@ludwig.ucl.ac.uk
Ridley
Anne J
AJ
D000818:Animals; D017209:Apoptosis; D005786:Gene Expression Regulation; D006801:Humans; D007328:Insulin / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D008954:Models, Biological; D009130:Muscle, Smooth / Q000378:metabolism; D010587:Phagocytosis; D010766:Phosphorylation; D010802:Phylogeny; D020033:Protein Isoforms; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D054460:rho-Associated Kinases
D007328:Insulin; D047908:Intracellular Signaling Peptides and Proteins; D020033:Protein Isoforms; D017346:Protein Serine-Threonine Kinases; D054460:rho-Associated Kinases