Postdecentralization plasticity of voltage-gated Na+ currents in rat glandular sympathetic neurons.
The kinetic properties of voltage-gated Na(+) currents in two groups of glandular postganglionic sympathetic neurons were assessed. The first group of neurons remained innervated by preganglionic axons until the day of current recordings, while the second--decentralized 4 weeks prior to recordings. An increase of maximum current amplitude and density was noted in decentralized neurons. Na(+) currents activated and time-dependently inactivated more slowly in decentralized than in control neurons. Furthermore, after decentralization the currents steady-state inactivated at less hyperpolarized potentials as well as reactivated faster from inactivation. We conclude that the Na(+) currents in decentralized postganglionic glandular sympathetic neurons undergo up-regulation.
Szulczyk
Bartłomiej
B
Department of Experimental and Clinical Physiology, Medical University of Warsaw, Faculty of Medicine, Krakowskie Przedmiescie 26/28, Warsaw 00-927, Poland.
Szulczyk
Paweł
P
D000578:Amidines / Q000378:metabolism; D000818:Animals; D004553:Electric Conductivity; D066298:In Vitro Techniques; D007700:Kinetics; D008564:Membrane Potentials; D009474:Neurons / Q000502:physiology*; D018408:Patch-Clamp Techniques / Q000379:methods; D051381:Rats; D026941:Sodium Channel Blockers / Q000494:pharmacology; D015222:Sodium Channels / Q000502:physiology*; D013363:Submandibular Gland / Q000294:innervation*; D017779:Sympathetic Fibers, Postganglionic / Q000166:cytology / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology; D013997:Time Factors; D015854:Up-Regulation
D000578:Amidines; D026941:Sodium Channel Blockers; D015222:Sodium Channels; C031455:diamidino compound 253-50; D013779:Tetrodotoxin