title: Lack of association of CCR2-64I and CCR5-Delta 32 with type 1 diabetes and latent autoimmune diabetes in adults.
abstract: It is well known that type 1 diabetes mellitus (T1DM) is a complex genetic disease resulting from the autoimmune destruction of pancreatic beta cells. Several genes have been associated with susceptibility and/or protection for T1DM, but the disease risk is mostly influenced by genes located in the class II region of the major histocompatibility complex. The attraction of leukocytes to tissues is essential for inflammation and the beginning of autoimmune reaction. The process is controlled by chemokines, which are chemotactic cytolines. Some studies have shown that CCR2-64I and CCR5-Delta 32 might be important for protection of susceptibility to some immunologically-mediated disorders. In the present study, we demonstrate the lack of association between CCR2-64I and CCR5-Delta 32 gene polymorphism and TIDM and we describe a new method for a simple and more precise genotyping of the CCR2 gene.
authors.affiliation: Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden. giovanni.gambelunghe@libero.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gambelunghe
authors.forename: Mehran
authors.initials: M
authors.lastname: Ghaderi
authors.forename: Annalisa
authors.initials: A
authors.lastname: Brozzetti
authors.forename: Paola
authors.initials: P
authors.lastname: Del Sindaco
authors.forename: Babeck
authors.initials: B
authors.lastname: Gharizadeh
authors.forename: Paul
authors.initials: P
authors.lastname: Nyren
authors.forename: Peter
authors.initials: P
authors.lastname: Hjelmström
authors.forename: Liene
authors.initials: L
authors.lastname: Nikitina-Zake
authors.forename: Carani B
authors.initials: CB
authors.lastname: Sanjeevi
authors.forename: Alberto
authors.initials: A
authors.lastname: Falorni
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D017354:Point Mutation; D054390:Receptors, CCR2; D019713:Receptors, CCR5 / Q000235:genetics*; D019707:Receptors, Chemokine / Q000235:genetics*; D017384:Sequence Deletion
chemical_list: C515334:CCR2 protein, human; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019707:Receptors, Chemokine