title: Perturbations in adiponectin, leptin and resistin levels in acromegaly: lack of correlation with insulin resistance.
abstract: BACKGROUND
  Insulin resistance, impaired glucose tolerance and type 2 diabetes are common in acromegalic subjects. The mechanism underlying this insulin resistance is unclear.
  
  
  METHODS
  We investigated the levels of the adipocytokines, resistin, adiponectin and leptin in a group of 18 acromegalic subjects and 18 control subjects matched for age, gender and body mass index.
  
  
  RESULTS
  Here we demonstrate for the first time significant elevation in adiponectin levels in acromegalic subjects compared to control subjects 12.5 +/- 1.2 vs. 8.97 +/- 1.1 mg/l, P = 0.029. The resistin levels were similar in acromegalic subjects and controls; 20.65 +/- 2.99 vs. 19.03 +/- 4.72 micro g/l. No evidence of a correlation between adiponectin and insulin resistance as calculated from HOMA-R was found. No correlation was observed either between adiponectin or resistin levels and GH levels, total IGF-I or free IGF-I levels. Leptin levels were significantly reduced in acromegalic subjects, 8.22 +/- 2.26 vs. 18.3 +/- 4.1 micro g/l, P = 0.004. In control subjects, significant correlations between leptin levels and HOMA-R and between resistin levels and HOMA-R were observed. These relationships were not apparent in acromegalic subjects.
  
  
  CONCLUSIONS
  From these data we conclude that changes in resistin and adiponectin levels are unlikely to account for the insulin resistance of acromegaly.
authors.affiliation: Department of Physiology, University of Manitoba, Winnipeg, Canada.
authors.forename: Josef V
authors.initials: JV
authors.lastname: Silha
authors.forename: Michal
authors.initials: M
authors.lastname: Krsek
authors.forename: Vaclav
authors.initials: V
authors.lastname: Hana
authors.forename: Josef
authors.initials: J
authors.lastname: Marek
authors.forename: Jana
authors.initials: J
authors.lastname: Jezkova
authors.forename: Vladimir
authors.initials: V
authors.lastname: Weiss
authors.forename: Liam J
authors.initials: LJ
authors.lastname: Murphy
mesh_terms: D000172:Acromegaly / Q000097:blood*; D052242:Adiponectin; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006729:Hormones, Ectopic / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin / Q000097:blood*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000032:analysis*; D052243:Resistin
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D006729:Hormones, Ectopic; D007328:Insulin; D018970:Insulin-Like Growth Factor Binding Protein 1; D018972:Insulin-Like Growth Factor Binding Protein 3; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D011506:Proteins; C499624:RETN protein, human; C486574:RETNLB protein, human; D052243:Resistin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone