title: [Analysis of cerebrospinal fluid related complications (hydrocephalus, fistula, pseudomeningocele and infection) following surgery for posterior fossa tumors].
abstract: BACKGROUND
  Hydrocephalus, cerebrospinal fluid (CSF) leak, pseudomeningocele and CSF infection are potential complications related to surgical treatment of posterior fossa tumors. The objectives of this study were to review the incidence of such complications and to identify contributing factors related to them.
  
  
  METHODS
  This study is based on a retrospective review of the medical records of 71 consecutive patients who underwent posterior fossa surgery for a tumor between the period January 1997 and December 2001. Postoperative hydrocephalus was defined as enlargement of the ventricles and the subsequent clinical worsening requiring surgical treatment. Criteria for CSF leakage were:observed leak of CSF through the wound, rhinorrhea or otorrhea. Pseudomeningocele was determined when there was a large epidural CSF collection diagnosed in the postoperative period or by magnetic resonance imaging performed at least three months after posterior fossa surgery. Finally, CSF infection was defined on clinical ground and positive biochemical examination, but not necessarily positive cultures.
  
  
  RESULTS
  The series included 84 operations for resection of posterior fossa tumors on 71 patients. There were CSF related complications in 31% (26/84)with the following detailed incidence: 9.5% (8/84) postoperative hydrocephalus; 14.3% (12/84) CSF leak, 7.1% (6/84) pseudomeningocele; 8.3% (7/84) CSF infection. The mortality rate is 5.9% (5/84). The tumor size was the only statistically significant factor associated with the occurrence of CSF related complications (mean 39.43 mm, SD 18.51 mm vs.29.80 mm, SD 14.12 mm, p=0.015). In the subgroup of patients, in which hydrocephalus was managed preoperatively, the election of an external ventricular drain vs.other strategies (subcutaneous reservoir, definite shunt or endoscopic third ventriculostomy) was associated with a higher occurrence of CSF related complications (p=0.006). The mortality rate was associated with age (mean 63.60 years, SD 5.86 years vs.49.18 years, SD 16.39 years; p=0.002). The occurrence of CSF related complications also influenced mortality (p=0.030), particularly postoperative hydrocephalus (p< 0.001). Inpatient hospital stay was longer in the subgroup of patients who developed CSF related complications (p=0.002).
  
  
  CONCLUSIONS
  Tumor size was the only factor associated with the development of CSF related complications after surgery for posterior fossa tumors. In the subgroup of patients in which hydrocephalus was surgically treated preoperatively, the election of an external ventricular drain compared to other surgical modalities was associated with a higher rate of CSF related complications. The development of such complications, particularly hydrocephalus, was related with mortality.
authors.affiliation: Servicio de Neurocirugía y Servicio de Otorrinolaringología y Patología Cervicofacial. Hospital Universitario de Salamanca Virgen de la Vega Salamanca, España.
authors.forename: D
authors.initials: D
authors.lastname: Santamarta
authors.forename: J A
authors.initials: JA
authors.lastname: Blázquez
authors.forename: A
authors.initials: A
authors.lastname: Maillo
authors.forename: A
authors.initials: A
authors.lastname: Muñoz
authors.forename: M
authors.initials: M
authors.lastname: Caballero
authors.forename: F
authors.initials: F
authors.lastname: Morales
mesh_terms: D001424:Bacterial Infections / Q000382:microbiology*; D001847:Bone Diseases / Q000209:etiology*; D002558:Cerebrospinal Fluid Otorrhea / Q000209:etiology*; D002559:Cerebrospinal Fluid Rhinorrhea / Q000209:etiology*; D003388:Cranial Fossa, Posterior / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008588:Meningocele / Q000209:etiology*; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications; D011300:Preoperative Care; D012888:Skull Neoplasms / Q000473:pathology / Q000601:surgery*