[Effects of acute infrasound exposure on vestibular and auditory functions and the ultrastructural changes of inner ear in the guinea pig].
OBJECTIVE
To define the effects of acute infrasound exposure on vestibular and auditory functions and the ultrastructural changes of inner ear in guinea pigs.


METHODS
The animals involved in the study were exposed to 8 Hz infrasound at 135dB SPL for 90 minutes in a reverberant chamber. The sinusoidal pendular test (SPT), auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) were respectively detected pre-exposure and at 0(within 2 hrs), 2 and 5 day after exposure. The ultrastructures of the inner ear were observed by scanning electron microscopy.


RESULTS
The slow-phase velocity and the frequency of the vestibular nystagmus elicited by sinusoidal pendular test (SPT) declined slightly following infrasound exposure, but the changes were not significant (P > 0.05). No differences in the ABR thresholds, the latencies and the interval peak latencies of I, III, V waves were found between the normal and the experimental groups, and among experimental groups. The amplitudes of DPOAE at any frequency declined remarkably in all experimental groups. The ultrastructures of the inner ear were damaged to different extent.


CONCLUSIONS
Infrasound could transiently depress the excitability of the vestibular end-organs, decrease the function of OHC in the organ of Corti and cause damage to the inner ear of guinea pigs.
Feng
B
B
Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of PLA, Beijing 100853, China. fbo@sina.com
Jiang
S
S
Yang
W
W
Han
D
D
Zhang
S
S
D000818:Animals; D007758:Ear, Inner / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000648:ultrastructure; D008297:Male; D008855:Microscopy, Electron, Scanning; D017084:Otoacoustic Emissions, Spontaneous; D013016:Sound; D014722:Vestibule, Labyrinth / Q000502:physiology*; D014732:Vibration