title: Cardiac adaptation in small for gestational age neonates after prenatal hemodynamic disturbances.
abstract: BACKGROUND
  Small for gestational age neonates with prenatal hemodynamic disturbances are at increased risk for neonatal morbidity. Investigations of fetal cardiac function have proved some functional impairments. The aim of the study was to investigate postnatal cardiac adaptation in these neonates in comparison with neonates without prenatal hemodynamic impairments.
  
  
  RESULTS
  Forty-one neonates with prenatal hemodynamic disturbances and 40 neonates with undisturbed prenatal hemodynamics were observed during the first 5 days of life. Doppler sonographic measurements of left ventricular time intervals, stroke volume, cardiac output and the incidence of patent ductus arteriosus were obtained in all neonates of both groups. Heart rate and blood pressure were recorded simultaneously.
  
  
  RESULTS
  A higher incidence of patent ductus arteriosus and a diminished stroke volume, but increased cardiac output, based on a significantly increased heart rate, were determined in SGA neonates with prenatal hemodynamic disturbances. In contrast, systolic left ventricular time intervals were not changed in these neonates, as expected.
  
  
  CONCLUSIONS
  The described findings could be signs of persistent hemodynamic impairments in growth-retarded neonates with prenatal disturbed hemodynamics. The neonates revealed a reduced ability to compensate the prenatal hemodynamic disturbances. This aspect should be included in the discussion of perinatal management in cases of severe growth retardation.
authors.affiliation: Department of Neonatology, University of Leipzig, Germany. eva_robel_tillig@web.de
authors.forename: Eva
authors.initials: E
authors.lastname: Robel-Tillig
authors.forename: Matthias
authors.initials: M
authors.lastname: Knüpfer
authors.forename: Christoph
authors.initials: C
authors.lastname: Vogtmann
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D002302:Cardiac Output; D015150:Echocardiography, Doppler; D006321:Heart / Q000196:embryology / Q000503:physiopathology*; D006330:Heart Defects, Congenital / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D011379:Prognosis; D011446:Prospective Studies; D016216:Ultrasonography, Prenatal; D016277:Ventricular Function, Left