Chemokine receptor CCR2 is not essential for the development of experimental cerebral malaria.
Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8(+) T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptor expressed on CD8(+) T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-type mice were, and CD8(+) T-cell migration to the brain was not abolished.
Belnoue
Elodie
E
Département d'Immunologie, Institut Cochin, INSERM U567, CNRS UMR 8104, Université René Descartes, Hôpital Cochin, Paris, France.
Costa
Fabio T M
FT
Vigário
Ana M
AM
Voza
Tatiana
T
Gonnet
Françoise
F
Landau
Irène
I
Van Rooijen
Nico
N
Mack
Matthias
M
Kuziel
William A
WA
Rénia
Laurent
L
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology; D016779:Malaria, Cerebral / Q000209:etiology* / Q000473:pathology; D008636:Mesencephalon / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D054390:Receptors, CCR2; D019713:Receptors, CCR5 / Q000502:physiology; D019707:Receptors, Chemokine / Q000502:physiology*
C515335:Ccr2 protein, mouse; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019707:Receptors, Chemokine