title: Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome.
abstract: The systemic inflammatory response syndrome (SIRS) is a major cause of morbidity and mortality, and is thought to be due to an over-amplification of an inflammatory response. The Toll-like receptor 4 ( TLR4 ) Asp-299-->Gly polymorphism has been shown to reduce lipopolysaccharide responsiveness. We examined whether this TLR4 polymorphism is associated with severity of SIRS. A trend was found between the minor allele and mortality in SIRS (odds ratio of 4.3; P =0.076), suggesting a role for TLR4 signalling in the severity of SIRS.
authors.affiliation: Human Genetics Division and Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, Southampton, UK.
authors.forename: N J A
authors.initials: NJ
authors.lastname: Child
authors.forename: I A
authors.initials: IA
authors.lastname: Yang
authors.forename: M C K
authors.initials: MC
authors.lastname: Pulletz
authors.forename: K
authors.initials: K
authors.lastname: de Courcy-Golder
authors.forename: A-L
authors.initials: AL
authors.lastname: Andrews
authors.forename: V J
authors.initials: VJ
authors.lastname: Pappachan
authors.forename: J W
authors.initials: JW
authors.lastname: Holloway
mesh_terms: D018806:APACHE; D000328:Adult; D005838:Genotype; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000235:genetics*; D018746:Systemic Inflammatory Response Syndrome / Q000235:genetics*; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors
chemical_list: D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors