[Heterogenicity of Gorham-Stout syndrome: association with lymphatic and venous malformations].
BACKGROUND
Gorham-Stout syndrome is a rare disorder of unknown etiology characterized by osteolysis and microscopic proliferation of abnormal vessels. We report two cases of this syndrome associated with lymphatic and venous malformations.


METHODS
The first case is a 5-year-old boy with disseminated lymphangiomatosis of poor prognosis, with significant pleural involvement and osteolytic lesions. The second case is a 5-year-old girl with a diagnosis of Klippel-Trenaunay syndrome with significant skeletal involvement of the lower extremities and secondary pathological fracture.


CONCLUSIONS
Gorham-Stout syndrome may occasionally be associated with various lymphatic and venous malformations. Osteolysis and bone resorption may be induced by lymphatic bone involvement.
Somoza Argibay
I
I
Unidad de Cirugía Plástica Infantil. Servicio de Cirugía Pediátrica. Hospital Materno Infantil La Paz. Madrid. España. isomoza@canalejo.org
Díaz González
M
M
Martínez Martínez
L
L
Ros Mar
Z
Z
López-Gutiérrez
J C
JC
D000998:Antiviral Agents / Q000627:therapeutic use; D001862:Bone Resorption / Q000175:diagnosis; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D018740:Genetic Heterogeneity; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D007715:Klippel-Trenaunay-Weber Syndrome / Q000175:diagnosis* / Q000235:genetics*; D008208:Lymphatic System / Q000002:abnormalities*; D008297:Male; D010014:Osteolysis / Q000175:diagnosis; D010015:Osteolysis, Essential / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D011994:Recombinant Proteins; D014680:Veins / Q000002:abnormalities*
D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins