title: [Nutritional therapy in surgical patients: an update].
abstract: Patients undergoing major gastrointestinal surgery, often require an adequate artificial nutritional (AN) support for a pre-existing state of malnutrition and/or to overcome forced periods of postoperative starvation and/or for complications that alter the host metabolic response. When an indication to AN is given, enteral feeding should be preferred to parenteral nutrition because more physiological and less expensive. Moreover, recent data showed that patients fed enterally, rather than parenterally, in the postoperative period, have a significant better outcome with a reduction of morbidity and hospitalisation. The supplementation of standard feeds with key nutrients having immunomodulatory properties, such as arginine, omega-3 fatty acids and glutamine (pharmaconutrients), allows to control effectively the surgery-induced immunosuppression and hyperinflammation. An analysis on the principles of evidence-based medicine, supports the hypothesis that the pre-perioperative use of formulas enriched with pharmaconutrients, significantly reduces the rate of infectious complications and saves health care resources.
authors.affiliation: Dipartimento di Scienze Chirurgiche e Terapia Intensiva, Università Milano-Bicocca, Monza, Italy. luca.gionotti@unimib.it
authors.forename: L
authors.initials: L
authors.lastname: Gianotti
authors.forename: L
authors.initials: L
authors.lastname: Nespoli
authors.forename: M
authors.initials: M
authors.lastname: Sargenti
authors.forename: A
authors.initials: A
authors.lastname: Nespoli
mesh_terms: D004750:Enteral Nutrition; D005526:Food, Formulated; D006801:Humans; D018529:Nutritional Support; D011182:Postoperative Care; D011184:Postoperative Period