Contrasting urban and rural lifestyles of memory CD8+ T cells.
Memory CD8(+) T cells in lymphoid tissue exhibit an unexpectedly high apoptosis rate, while memory cells located in several nonlymphoid tissues do not. This may be because the lymphoid CD8(+) memory T cell repertoire is being continuously updated, while the tissue repertoire is more stable.
Topham
David J
DJ
The David H. Smith Center for Vaccine Biology and Immunology, The University of Rochester, Rochester, NY 14642, USA.
Crispe
I Nicholas
IN
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002470:Cell Survival / Q000276:immunology; D007156:Immunologic Memory; D008221:Lymphoid Tissue / Q000276:immunology; D008297:Male; D051379:Mice; D009928:Organ Specificity / Q000276:immunology