title: Hierarchical active shape models, using the wavelet transform.
abstract: Active shape models (ASMs) are often limited by the inability of relatively few eigenvectors to capture the full range of biological shape variability. This paper presents a method that overcomes this limitation, by using a hierarchical formulation of active shape models, using the wavelet transform. The statistical properties of the wavelet transform of a deformable contour are analyzed via principal component analysis, and used as priors in the contour's deformation. Some of these priors reflect relatively global shape characteristics of the object boundaries, whereas, some of them capture local and high-frequency shape characteristics and, thus, serve as local smoothness constraints. This formulation achieves two objectives. First, it is robust when only a limited number of training samples is available. Second, by using local statistics as smoothness constraints, it eliminates the need for adopting ad hoc physical models, such as elasticity or other smoothness models, which do not necessarily reflect true biological variability. Examples on magnetic resonance images of the corpus callosum and hand contours demonstrate that good and fully automated segmentations can be achieved, even with as few as five training samples.
authors.affiliation: Section for Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA. hristos@rad.jhu.edu
authors.forename: Christos
authors.initials: C
authors.lastname: Davatzikos
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Tao
authors.forename: Dinggang
authors.initials: D
authors.lastname: Shen
mesh_terms: D000465:Algorithms; D019412:Anatomy, Cross-Sectional / Q000379:methods; D003337:Corpus Callosum / Q000033:anatomy & histology*; D004548:Elasticity; D006225:Hand / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D009038:Motion; D010363:Pattern Recognition, Automated