The role of the IKAP gene polymorphisms in atopic diseases in the middle European population.
Over ten genome-wide screens and many candidate genes studies were performed worldwide to elucidate genetic factors involved in the pathogenesis of bronchial asthma and other atopic diseases. Results from these studies were often discordant, which might have reflected complexity and heterogeneity of these multifactorial diseases. Among a variety of other loci, specific variants of the gene for IKAP (IKK complex-associated protein) were shown to be associated with bronchial asthma in children in a Japanese study. To test the possible role of SNPs in the coding region of the IKAP gene in atopic asthma or other atopic phenotypes in a highly homogenous Czech population, a case-control study including 373 patients and 309 healthy control subjects was performed. There were no significant differences in the genotype and allele distributions for any of five SNPs in the IKAP gene (T819C, G2295A, A2490G, T3214A and C3473T) between patients with atopic asthma or other atopic diseases and healthy controls. These results suggest that the polymorphisms in the coding region of the IKAP gene are unlikely to contribute to atopic disease risk in the Czech population.
Schüller
Marcel
M
Department of Pathological Physiology, Medical Faculty, Masaryk University Brno, Komenského nám. 2, 662 43, Brno, Czech Republic. schuller@med.muni.cz.
Izakovičová Hollá
Lydie
L
Department of Pathological Physiology, Medical Faculty, Masaryk University Brno, Komenského nám. 2, 662 43, Brno, Czech Republic.
Bučková
Dana
D
Department of Pathological Physiology, Medical Faculty, Masaryk University Brno, Komenského nám. 2, 662 43, Brno, Czech Republic.
Znojil
Vladimír
V
Department of Pathological Physiology, Medical Faculty, Masaryk University Brno, Komenského nám. 2, 662 43, Brno, Czech Republic.
Štelcl
Marcel
M
Department of Obstetrics and Gynecology, Hospital Vyskov, Czech Republic.
Rybníček
Ondřej
O
Second Department of Paediatrics, Faculty Children Hospital Brno, Czech Republic.
Vácha
Jiří
J
Department of Pathological Physiology, Medical Faculty, Masaryk University Brno, Komenského nám. 2, 662 43, Brno, Czech Republic.
D000328:Adult; D000483:Alleles; D001249:Asthma / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D018153:Czech Republic; D003876:Dermatitis, Atopic / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics; D035602:Transcriptional Elongation Factors; D044465:White People / Q000235:genetics*
D002352:Carrier Proteins; C114720:Elp1 protein, human; D035602:Transcriptional Elongation Factors