FXYD7, the first brain- and isoform-specific regulator of Na,K-ATPase: biosynthesis and function of its posttranslational modifications.
The FXYD protein family has recently been defined as a result of the search for homologues of the Na,K-ATPase gamma subunit, CHIF, and phospholemman in EST and gene data banks. FXYD7 has been seen to have a role as a brain- and isozyme-specific regulator of Na/K-ATPase. In this study, the biosynthesis, membrane topology, nature, and role of the processing of FXYD7 are investigated.
Crambert
Gilles
G
Institute of Pharmacology and Toxicology, University of Lausanne, Switzerland.
Béguin
Pascal
P
Uldry
Marc
M
Monnet-Tschudi
Florianne
F
Horisberger
Jean-Daniel
JD
Garty
Haim
H
Geering
Käthi
K
D000818:Animals; D001921:Brain / Q000378:metabolism; D007700:Kinetics; D008562:Membrane Glycoproteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D000254:Sodium-Potassium-Exchanging ATPase / Q000096:biosynthesis*
C462940:Fxyd7 protein, mouse; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D020033:Protein Isoforms; D000254:Sodium-Potassium-Exchanging ATPase