title: Five new cases of juvenile renal cell carcinoma with translocations involving Xp11.2: a cytogenetic and morphologic study.
abstract: Two cases of renal cell carcinoma (RCC) carrying a t(X;1)(p11.2;q21) in a 12-year-old boy and a 14 year-old girl, two cases with a t(X;1)(p11.2;p34) in a 9-year-old boy and a 31-year-old woman, and one case with a t(X;17)(p11.2;q25) in a 15-year-old boy are reported. Two are likely papillary RCC, with clear or slightly eosinophilic cells, and two to a clear cell RCC; one shows a mixture of papillary and clear cell RCC architecture. Renal cell carcinomas with translocations involving Xp11.2 form a specific entity characterized by subtle pathologic features and younger age of occurrence, especially for those with the t(X;17).
authors.affiliation: Laboratoire de Cytogénétique, Hôpital Saint-Antoine, Paris, France. christine.perot@sat.ap-hop-paris.fr
authors.forename: Christine
authors.initials: C
authors.lastname: Pérot
authors.forename: Liliane
authors.initials: L
authors.lastname: Boccon-Gibod
authors.forename: Raymonde
authors.initials: R
authors.lastname: Bouvier
authors.forename: François
authors.initials: F
authors.lastname: Doz
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Fournet
authors.forename: Paul
authors.initials: P
authors.lastname: Fréneaux
authors.forename: Annick
authors.initials: A
authors.lastname: Vieillefond
authors.forename: Jérôme
authors.initials: J
authors.lastname: Couturier
mesh_terms: D000293:Adolescent; D000328:Adult; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology; D002648:Child; D041321:Chromosomes, Human, X / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D014178:Translocation, Genetic / Q000235:genetics*