Functionally mature virus-specific CD8(+) T memory cells in congenitally infected newborns: proof of principle for neonatal vaccination?
The presence in newborns of a mature and functional CD8(+) T cell response to congenital cytomegalovirus infection suggests that the machinery necessary to prime such responses is present in utero and raises questions related to neonatal vaccination.
Holt
P G
PG
Telethon Institute for Child Health Research and Centre for Child Health Research, Faculty of Medicine and Dentistry, University of Western Australia, Perth, Western Australia, Australia. patrick@ichr.uwa.edu.au
D016827:CD8 Antigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007114:Immunization / Q000379:methods*; D007156:Immunologic Memory; D007231:Infant, Newborn; D008954:Models, Biological; D014612:Vaccines
D016827:CD8 Antigens; D014612:Vaccines