title: Trehalose metabolism: a regulatory role for trehalose-6-phosphate?
abstract: Trehalose is a disaccharide that was initially thought to be rare in plants but now appears to be ubiquitous. A recent study has established that the initial step in trehalose synthesis is essential in Arabidopsis. Evidence is emerging that the precursor of trehalose (trehalose-6-phosphate) is an important regulatory molecule. In yeast, trehalose-6-phosphate regulates sugar influx into glycolysis. In plants, trehalose-6-phosphate also appears to regulate sugar metabolism, but the underlying mechanism is unresolved and may be substantially different from that in yeast.
authors.affiliation: Centre for Novel Agricultural Products, Department of Biology, Area 7, University of York, PO Box 373, York YO10 5YW, UK.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Eastmond
authors.forename: Ian A
authors.initials: IA
authors.lastname: Graham
mesh_terms: D050260:Carbohydrate Metabolism; D015971:Gene Expression Regulation, Enzymologic; D005964:Glucosyltransferases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006019:Glycolysis / Q000235:genetics / Q000502:physiology; D008968:Molecular Conformation; D010944:Plants / Q000201:enzymology* / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D012639:Seeds / Q000201:enzymology / Q000235:genetics; D013403:Sugar Phosphates / Q000378:metabolism*; D014199:Trehalose / Q000031:analogs & derivatives* / Q000378:metabolism*
chemical_list: D013403:Sugar Phosphates; C082722:trehalose-6-phosphate; D014199:Trehalose; D005964:Glucosyltransferases; C023180:trehalose-6-phosphate synthase