title: Prevalence of transfusion-transmissible viral infections in first-time US blood donors by donation site.
abstract: BACKGROUND
  Understanding the donor base, infectious disease prevalence, and donation loss at various blood donation sites will help maximize blood collection efforts and blood availability.
  
  
  METHODS
  Using donation data collected at five US blood centers, the prevalence of HIV, HTLV, HBsAg, and HCV in first-time whole-blood donations at 10 donation sites was evaluated: military, education, religious, professional, industry, services, community, health care, government, and fixed sites. Donation loss from screening test reactivity at each donation site was also evaluated.
  
  
  RESULTS
  During the study, 1.2 million first-time whole-blood donations were collected. Military and education sites had a low prevalence of all viral markers, except for HBsAg, which was highest at education sites. Variations in viral marker prevalence among donation sites were partially explained by donor demographic differences. Donation loss varied by donation site, ranging from 3.3 percent at education sites to 6.4 percent at industry sites, indicating differential efficiency of blood collection efforts.
  
  
  CONCLUSIONS
  Different rates of positive viral test results and donation loss in first-time whole-blood donors were observed at various types of donation sites. This information may be useful in estimating the yield of usable units from specific blood drives and in allocating resources to meet blood center collection goals.
authors.affiliation: Westat, Rockville, Maryland 20850, USA. baoguangwang@westat.com
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: G B
authors.initials: GB
authors.lastname: Schreiber
authors.forename: S A
authors.initials: SA
authors.lastname: Glynn
authors.forename: C C
authors.initials: CC
authors.lastname: Nass
authors.forename: J W
authors.initials: JW
authors.lastname: Smith
authors.forename: M J
authors.initials: MJ
authors.lastname: Higgins
authors.forename: S T
authors.initials: ST
authors.lastname: Hutching
authors.forename: D J
authors.initials: DJ
authors.lastname: Wright
authors.forename: R L
authors.initials: RL
authors.lastname: McEntire
authors.forename: E L
authors.initials: EL
authors.lastname: Murphy
mesh_terms: D000328:Adult; D000368:Aged; D001782:Blood Donors; D005260:Female; D015658:HIV Infections / Q000453:epidemiology; D015490:HTLV-I Infections / Q000453:epidemiology; D006526:Hepatitis C / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D065227:Transfusion Reaction; D014777:Virus Diseases / Q000453:epidemiology* / Q000635:transmission*