title: Kidney-pancreas transplantation in a long-term non-progressor HIV-infected recipient.
abstract: With the introduction of highly active antiretroviral therapy (HAART), HIV infection has become a chronic disease with more frequent end-stage organ failures. As a result, the question of transplantation in HIV patients is raised more often. Although still subject to controversies, HIV infection is no longer an absolute contraindication to solid organ transplantation. We report a case of combined kidney-pancreas transplantation in a HIV recipient. HIV has remained stable without any antiviral therapy for up to 2 years after transplantation and has reached criteria for inclusion in the long-term nonprogressor (LTNP) group. Grafted organs demonstrated good function without rejection. This case emphasizes the need to consider LTNP HIV patients as a specific subgroup, when discussing solid organ transplantation. HAART is not required, thus sparing drug interactions and their unique immunological features, such as CCR5 mutation, might prevent rejection. This subgroup of HIV patients should be offered less restricted access to transplantation.
authors.affiliation: Transplantation Unit, Visceral and Transplant Surgery, University Hospitals, Geneva, Switzerland. christian.toso@hcuge.ch
authors.forename: Christian
authors.initials: C
authors.lastname: Toso
authors.forename: Thierry
authors.initials: T
authors.lastname: Berney
authors.forename: José
authors.initials: J
authors.lastname: Oberholzer
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Chave
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Martin
authors.forename: Eve
authors.initials: E
authors.lastname: Zeender
authors.forename: Domenico
authors.initials: D
authors.lastname: Bosco
authors.forename: Philippe
authors.initials: P
authors.lastname: Morel
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000150:complications; D006679:HIV Seropositivity; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D016035:Pancreas Transplantation / Q000379:methods*; D010182:Pancreatic Diseases / Q000209:etiology; D019713:Receptors, CCR5 / Q000235:genetics; D051437:Renal Insufficiency / Q000209:etiology; D013997:Time Factors
chemical_list: D019713:Receptors, CCR5