title: Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. II. Isolation, characterization, and structure determination.
abstract: A new group of thiazolyl peptide antibiotics, the nocathiacins, was isolated from cultured broth of Nocardia sp. The major analogs nocathiacins I-III (1-3) were purified using silica gel and Sephadex LH-20 chromatography techniques. The structures of nocathiacins I-III were determined by spectroscopic (2D-NMR, MSn) methods, and share structural similarities to glycothiohexide-alpha (4).
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA. leetj@bms.com
authors.forename: John E
authors.initials: JE
authors.lastname: Leet
authors.forename: Wenying
authors.initials: W
authors.lastname: Li
authors.forename: Helen A
authors.initials: HA
authors.lastname: Ax
authors.forename: James A
authors.initials: JA
authors.lastname: Matson
authors.forename: Stella
authors.initials: S
authors.lastname: Huang
authors.forename: Ron
authors.initials: R
authors.lastname: Huang
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Cantone
authors.forename: Dieter
authors.initials: D
authors.lastname: Drexler
authors.forename: Richard A
authors.initials: RA
authors.lastname: Dalterio
authors.forename: Kin S
authors.initials: KS
authors.lastname: Lam
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification*; D002850:Chromatography, Gel; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009615:Nocardia / Q000737:chemistry*; D010455:Peptides; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides