HLA antigens and primary osteoarthritis of the hand.
OBJECTIVE
Many studies have examined genetic factors associated with either development or severity of primary osteoarthritis (OA). Analyses of the frequencies of HLA antigens in various OA populations have yielded conflicting results; an increased frequency of HLA-A1, B8, and DR4 alleles has been suggested. We investigated the interrelationship between HLA antigens and primary OA.


METHODS
We analyzed the frequency of HLA-A, B, C, DR, and DQ antigens in 95 patients (82 women, 13 men) with primary OA of the hands compared to 200 controls matched for age, sex, and ethnicity. Class I and Class II HLA antigens were evaluated using conventional serologic typing.


RESULTS
No statistically significant difference in the distribution of HLA-A1 and B8 antigens was observed in patients with OA compared to controls. By contrast, HLA-B35, B40, DQ1, and CW4 antigens were overrepresented in the OA patients. Haplotype analysis showed an association of B35-DQ1, B40-DQ1, and DR2-DQ1 with increased OA risk.


CONCLUSIONS
Our results suggest a role of the HLA system in the etiopathogenesis of primary OA of the hand.
Merlotti
Daniela
D
Department of Internal Medicine, University of Siena, Italy.
Santacroce
Clorinda
C
Gennari
Luigi
L
Geraci
Simone
S
Acquafredda
Vincenzo
V
Conti
Tullio
T
Bargagli
Gianluca
G
Canto
Norberto Dal
ND
Biagi
Federica
F
Gennari
Carlo
C
Giordano
Nicola
N
D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006225:Hand; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000453:epidemiology / Q000235:genetics*; D015995:Prevalence
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens