title: Cyclooxygenase-2 in the hippocampus is up-regulated in Alzheimer's disease but not in variant Alzheimer's disease with cotton wool plaques in humans.
abstract: We examined neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, and neuron densities in the CA1-4 of the hippocampus in three cases of Alzheimer's disease with cotton wool plaques (CWP-AD), 17 cases of typical Alzheimer's disease without CWPs (tAD), and 26 normal controls. Cyclooxygenase-2 expression was significantly increased in all of the CA1-4 in tAD, but not in any subdivision in CWP-AD, compared with controls. Cyclooxygenase-2 expression in tAD was also significantly up-regulated compared with that in CWP-AD in all subdivisions. Furthermore, neuron density in the hippocampus was not significantly reduced in CWP-AD cases compared with controls despite remarkable intra- and extraneuronal Abeta deposition. These findings suggest that unknown factors besides Abeta deposition are necessary for the cyclooxygenase-2 up-regulation and neurodegeneration in Alzheimer's disease.
authors.affiliation: Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan. oyokota1@yahoo.co.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokota
authors.forename: Seishi
authors.initials: S
authors.lastname: Terada
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishizu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishihara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ujike
authors.forename: Hanae
authors.initials: H
authors.lastname: Nakashima
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Aki
authors.initials: A
authors.lastname: Kugo
authors.forename: Frédéric
authors.initials: F
authors.lastname: Checler
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Kuroda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology; D001921:Brain / Q000473:pathology*; D002452:Cell Count; D051546:Cyclooxygenase 2; D005260:Female; D006624:Hippocampus / Q000201:enzymology*; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis* / Q000235:genetics; D017966:Pyramidal Cells / Q000201:enzymology; D013702:Temporal Lobe / Q000473:pathology; D015854:Up-Regulation / Q000235:genetics*
chemical_list: D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases