Localized epidural and bone amyloidosis, rare cause of paraplegia in multiple myeloma.
We report two cases of spinal cord compression by AL amyloid deposits in the setting of multiple myeloma. The first patient, a 57 year old man, had a surgical procedure late in his course, when his neurological status worsened despite medical treatment. The second patient, a 61 year old man, had surgical treatment as soon as vertebral body collapse and epiduritis were diagnosed and spinal amyloidosis revealed a non secretory myeloma. Neurological recovery was significant in both cases and neither developed manifestations of systemic amyloidosis 4 years later.
Laurat
Elisabeth
E
Department of Adult Medicine, Centre hospitalier universitaire, 16 Boulevard de Bulgarie, 35203 Rennes, France.
Cazalets
Claire
C
Sébillot
Martine
M
Bernard
Marc
M
Caulet-Maugendre
Sylvie
S
Grosbois
Bernard
B
D000686:Amyloidosis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D001842:Bone and Bones / Q000473:pathology*; D004824:Epidural Space / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D010264:Paraplegia / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D013117:Spinal Cord Compression / Q000209:etiology* / Q000473:pathology* / Q000601:surgery; D013904:Thoracic Vertebrae