title: [Evolution of tissue structures in the mandible after implantation of plate from polymethylmethacrylate and its compositions with hydroxyapatite].
abstract: Tissue reactions to active modified composite material were studied in experiments on Chinchilla rabbits. In the first series of experiments plates from composite material were implanted: polymethylmethacrylate (PMMA) plates were used in group 1, PMMA composition with hydroxyapatite (HAP) in group 2, and PMMA composition with HAP modified by polyacrylic acid in group 3. The content of HAP in each group was 30% by weight. Implantation of plates from pure PMMA induced atrophic processes with formation of connective tissue capsule at the site of implantation. In the second series of experiments the manifestations of inflammatory reactions in the bone and adjacent tissues, caused by HAP release into tissue, were observed, which were paralleled by activation of bone formation, which sometimes acquired the pattern of a hyperproductive reaction. PMMA/HAP composite modified by chemical bond proved to be the most effective: its implantation caused no manifest pathological reactions and inflammatory infiltration; no intraosseous deposition of crystals were detected. Intensive osteogenesis round the implanted plate was observed.
authors.forename: A S
authors.initials: AS
authors.lastname: Grigorian
authors.forename: A I
authors.initials: AI
authors.lastname: Volozhin
authors.forename: A P
authors.initials: AP
authors.lastname: Krasnov
authors.forename: T T
authors.initials: TT
authors.lastname: Biriukbaev
authors.forename: C V
authors.initials: CV
authors.lastname: Kholodov
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Chergeshtov
mesh_terms: D000818:Animals; D001697:Biomedical and Dental Materials / Q000627:therapeutic use*; D017886:Durapatite / Q000627:therapeutic use*; D008334:Mandible / Q000187:drug effects / Q000473:pathology* / Q000601:surgery; D019930:Mandibular Prosthesis Implantation; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology; D019904:Polymethyl Methacrylate / Q000627:therapeutic use*; D011817:Rabbits
chemical_list: D001697:Biomedical and Dental Materials; D019904:Polymethyl Methacrylate; D017886:Durapatite