IB-00208, a new cytotoxic polycyclic xanthone produced by a marine-derived Actinomadura. I. Isolation of the strain, taxonomy and biological activites.
A new compound, IB-00208, has been isolated from the fermentation broth of an actinomycete isolated from a marine environment. The strain was identified as Actinomadura sp. by its chemical and phylogenetic characteristics. The compound shows cytotoxic activity on tumor cell lines and bactericidal activity against gram-positive bacteria.
Malet-Cascón
Leyre
L
Instituto Biomar S.A. Pol. Ind. de Leon. Edif. CEEI, Onzonilla, 2423 1-Leon, Spain.
Romero
Francisco
F
Espliego-Vázquez
Fernando
F
Grávalos
Dolores
D
Fernández-Puentes
José Luis
JL
D000192:Actinomycetales / Q000737:chemistry* / Q000145:classification; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D001483:Base Sequence; D004269:DNA, Bacterial / Q000737:chemistry; D004275:DNA, Ribosomal / Q000737:chemistry; D005285:Fermentation; D005960:Glucosides / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010802:Phylogeny; D014966:Xanthenes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D005960:Glucosides; C474717:IB 00208; D014966:Xanthenes