Electrical turbulence as a result of the critical curvature for propagation in cardiac tissue.
In cardiac tissue, the propagation of electrical excitation waves is dependent on the active properties of the cell membrane (ionic channels) and the passive electrical properties of cardiac tissue (passive membrane properties, distribution of gap junctions, and cell shapes). Initiation of cardiac arrhythmias is usually associated with heterogeneities in the active and/or passive properties of cardiac tissue. However, as a result of the effect of wave front geometry (curvature) on propagation of cardiac waves, inexcitable anatomical obstacles, like veins and arteries, may cause the formation of self-sustained vortices and uncontrolled high-frequency excitation in normal homogeneous myocardium. (c) 1998 American Institute of Physics.
Cabo
Candido
C
Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, New York 10032.
Pertsov
Arkady M.
AM
Davidenko
Jorge M.
JM
Jalife
Jose
J