title: Intraocular extramedullary plasmacytoma in a cat.
abstract: An 8-year-old, castrated male Domestic Short-haired cat was referred for evaluation of a possible intraocular neoplasm following previous ocular trauma. The eye was blind, and uveitis and an iridal mass were noted on examination. An enucleation was performed and the mandibular lymph node excised. Histopathologic examination revealed neoplastic proliferation of plasma cells in the iris and lymph node. No other evidence of disseminated disease was detected. This is the first case reported of an intraocular extramedullary plasmacytoma in the cat. The variation in clinical manifestations and potential association with multiple myeloma are not known at this time. Disseminated metastasis from a primary plasmacytoma of the uveal tract could also involve the bone marrow and be indistinguishable from multiple myeloma. Early enucleation, as in trauma-associated sarcomas, may be indicated to prevent metastasis. Periodic systemic evaluation for evidence of multiple myeloma should be performed.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh 27606, USA. tmiller@unity.ncsu.edu
authors.forename: Tammy Miller
authors.initials: TM
authors.lastname: Michau
authors.forename: David R
authors.initials: DR
authors.lastname: Proulx
authors.forename: Steven D
authors.initials: SD
authors.lastname: Rushton
authors.forename: Thierry
authors.initials: T
authors.lastname: Olivry
authors.forename: Stanley M
authors.initials: SM
authors.lastname: Dunston
authors.forename: Brian C
authors.initials: BC
authors.lastname: Gilger
authors.forename: Michael G
authors.initials: MG
authors.lastname: Davidson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001766:Blindness / Q000209:etiology / Q000662:veterinary; D002371:Cat Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D002415:Cats; D004359:Drug Therapy, Combination; D005131:Eye Injuries / Q000150:complications / Q000662:veterinary; D005134:Eye Neoplasms / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D008207:Lymphatic Metastasis; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D017233:Orbit Evisceration / Q000662:veterinary; D010954:Plasmacytoma / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D008558:Melphalan; D011241:Prednisone