[Relationship between expression of multiple tumor suppressor(MTS1) and E-cadherin and metastasis of breast carcinoma].
OBJECTIVE
Most of breast cancer patients died of distant metastasis. There is still not a method of predicting and early diagnosing the metastasis. This study was conducted to investigate the relationship between the expression of multiple tumor suppressor 1(MTS1) as well as E-cadherin and metastasis in breast cancer.


METHODS
The expression of MTS1 and E-cadherin were detected by SP immunohistochemical technique in 54 paraffin-embedded tissue specimens of breast cancer.


RESULTS
The positive rates of MTS1 in the distant metastasis group and more than 4 local lymph node metastasis group were 40.7% and 38.1%, respectively, which were lower than individual corresponding control groups (74.1% and 69.7%) (P< 0.05). The MTS1 expression rates in the three groups of pathology grade I, II, and III were 72.6%, 58.8%, and 31.3%, respectively, with significant differences (P< 0.05). The positive rates of E-cadherin in the distant metastasis group and more than 4 local lymph node metastasis group were 37% and 23.8%, respectively, which are lower than individual corresponding control groups (70.4% and 66.7%) (P< 0.05). The E-cadherin expression rates in the three groups of pathology grade I, II, III were 80.9%, 47.1%,and 25%, respectively, with significant differences (P< 0.01).


CONCLUSIONS
There was a close relation between MTS1, E-cadherin and invasion, metastasis of breast cancer. They can be used as the biological markers for evaluating the latent metastasis, disease development, and prognosis in breast cancer.
Song
Zhen-Chuan
ZC
Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, PR China. zhenchuansong@hotmail.com
Wang
Gui-Lan
GL
Qi
Yi-Xin
YX
Cui
Dong-Chen
DC
Li
Yong
Y
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D015820:Cadherins / Q000096:biosynthesis*; D005260:Female; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D019942:Genes, p16; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis
D015820:Cadherins