[Lipid peroxidation and enzymes of the antioxidant defense system in patients with bronchial asthma].
In 71 patient with bronchial asthma (BA), lipid peroxidation (LPO) was studied together with the condition of the antioxidant system (AOS) as related to the degree of severity of the illness, with results evaluated of conventional therapy versus complex treatment involving the use of cytochrome C. Established in the above series was intensification of LPO in the presence of inhibition of activity of SOD enzymes and catalase, their degree dependent on severity of the condition. Unlike basic therapy, employment of cytochrome C has been found to be associated with a more complete restoration of balance in the LPO/AOS system, especially so in steroid-independent form of BA.
Abdullaev
S F
SF
Inoiatov
F Sh
FSh
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000097:blood / Q000201:enzymology* / Q000378:metabolism*; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D003574:Cytochrome c Group / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D003574:Cytochrome c Group; D008054:Lipid Peroxides; D002374:Catalase; D013482:Superoxide Dismutase