[Study on improvement of dissolution rate of water-honeyed pills of six herbs with rehmunnia by technique of super fine crushing].
OBJECTIVE
To evaluate the affection of crushing technology on quality. The dissolution of Pills of Six Herbs with Rehmunnia prepared by different crushing technology was determined by taking the dissolution of Paeonol as test marker.


METHODS
The Pills was prepared with the fine powder which was crushed by normal crusher or super fine crusher. The rotatory-basket method was used, and the cumulative dissolution percentage was determined by UV.


RESULTS
Statistics indicated there was a significant difference in dissolution parameter (T50) between super fine crushing powder Pills and normal fine-crushing powder Pills (P < 0.01), and there was a difference in dissolution of different batches of Pills of Six Herbs with Rehmunnia prepared by the normal crush technique (P < 0.05).


CONCLUSIONS
The determination of dissolution of Pills of Six Herbs with Rehmunnia is necessary. In order to improve the quality of drugs, we should adopt the technique of super fine crushing in the preparation procedure.
Su
Rui-qiang
RQ
Shandong Lunan Pharmaceutical Factory, Linyi 276003, Shandong, China.
He
Yu
Y
Wang
Rui-cheng
RC
Zhao
Lian-hua
LH
D000098:Acetophenones / Q000032:analysis / Q000737:chemistry*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000302:isolation & purification; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry*; D011786:Quality Control; D032267:Rehmannia / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
D000098:Acetophenones; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C042579:Liuwei Dihuang Decoction; C013638:paeonol