title: Differential gene expression in distinct virologic types of hepatocellular carcinoma: association with liver cirrhosis.
abstract: Using oligonucleotide microarray data of 45 hepatocellular carcinoma (HCC) samples, we evaluated gene expression in hepatitis B virus-positive and hepatitis C virus-positive HCCs (HBV- and HCV-HCCs) for an association with liver cirrhosis (LC). In all, 89 genes were expressed differentially between HBV-HCCs associated with LC and those not associated with LC. Among them, tumors from LC patients showed significantly lower expression levels of 72 genes and significantly higher levels of 17 genes than the levels found in tumors from non-LC patients. The former included genes responsible for signal transduction, transcription, metabolism, and cell growth. The latter included a tumor suppressor gene and a cell-growth-related gene. Only eight genes were expressed differentially between HCV-HCCs associated with and without LC. Our findings provide as a framework for clarifying the role of LC in HBV- and HCV-related hepatocarcinogenesis.
authors.affiliation: Department of Surgery II, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Iizuka
authors.forename: Masaaki
authors.initials: M
authors.lastname: Oka
authors.forename: Hisafumi
authors.initials: H
authors.lastname: Yamada-Okabe
authors.forename: Naohide
authors.initials: N
authors.lastname: Mori
authors.forename: Takao
authors.initials: T
authors.lastname: Tamesa
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Okada
authors.forename: Norikazu
authors.initials: N
authors.lastname: Takemoto
authors.forename: Kiichiro
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Akira
authors.initials: A
authors.lastname: Tangoku
authors.forename: Kenji
authors.initials: K
authors.lastname: Hamada
authors.forename: Hironobu
authors.initials: H
authors.lastname: Nakayama
authors.forename: Takanobu
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Shunji
authors.initials: S
authors.lastname: Uchimura
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hamamoto
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000235:genetics* / Q000821:virology*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D015967:Gene Expression Regulation, Viral; D016174:Hepacivirus / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014412:Tumor Virus Infections / Q000150:complications / Q000235:genetics*