Experience-dependent slow-wave sleep development.
Sleep enhances plasticity in neocortex, and thereby improves sensory learning. Here we show that sleep itself undergoes changes as a consequence of waking experience during a late critical period in cats and mice. Dark-rearing produced a robust and reversible decrement of slow-wave electrical activity during sleep that was restricted to visual cortex and impaired by gene-targeted reduction of NMDA receptor function.
Miyamoto
Hiroyuki
H
Lab for Neuronal Circuit Development, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.
Katagiri
Hiroyuki
H
Hensch
Takao
T
D000375:Aging / Q000235:genetics; D000818:Animals; D002415:Cats; D003623:Dark Adaptation / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D009473:Neuronal Plasticity / Q000235:genetics*; D016194:Receptors, N-Methyl-D-Aspartate / Q000172:deficiency / Q000235:genetics; D012677:Sensation / Q000235:genetics*; D012683:Sensory Deprivation / Q000502:physiology; D012890:Sleep / Q000235:genetics*; D009435:Synaptic Transmission / Q000235:genetics; D013788:Thalamus / Q000254:growth & development* / Q000502:physiology; D014793:Visual Cortex / Q000254:growth & development* / Q000502:physiology; D014795:Visual Pathways / Q000254:growth & development* / Q000502:physiology; D014851:Wakefulness / Q000235:genetics*
C120997:NR2A NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate