title: [Association of HMG-CoA reductase gene polymorphism with levels of lipids].
abstract: OBJECTIVE
  To study the distribution of ScrF1 restriction polymorphism in intron 2 of the 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase gene in Chinese Han population and the association of the polymorphism with coronary heart disease(CHD).
  
  
  METHODS
  HMG-CoA reductase genotyping was performed using polymerase chain reaction-restriction fragment polymorphism.
  
  
  RESULTS
  HMG-CoA reductase allelic frequencies of A, a were 0.519, 0.481; 0.440, 0.560 in CHD group and control group respectively. There was no significant difference in frequencies of allele and genotype in ScrF1 polymorphism between CHD group and control group(P>0.05). However, the levels of plasma very low density lipoprotein (VLDL) and TG in CHD patients with AA genotype were higher than those in CHD patients with other genotypes(P<0.05). The frequencies of A, a alleles at ScrF1 polymorphic site were significantly different from those reported in European Caucasians (0.44 vs 0.55, 0.56 vs 0.45, P<0.05).
  
  
  CONCLUSIONS
  No direct association was found between the ScrF1 polymorphism and CHD, but there is a significant correlation between the AA genotype of the HMG-CoA reductase gene and the levels of plasma VLDL and TG in CHD group.
authors.affiliation: Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tong
authors.forename: Si-zhong
authors.initials: SZ
authors.lastname: Zhang
authors.forename: Zhi-guang
authors.initials: ZG
authors.lastname: Su
authors.forename: Xiang-dong
authors.initials: XD
authors.lastname: Kong
authors.forename: Jia-jun
authors.initials: JJ
authors.lastname: Shi
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Heng-yu
authors.initials: HY
authors.lastname: Zhang
authors.forename: Ke-lan
authors.initials: KL
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D001774:Blood Chemical Analysis; D015243:Cholesterol, VLDL / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics*; D025782:Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent / Q000235:genetics; D050356:Lipid Metabolism / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood
chemical_list: D015243:Cholesterol, VLDL; D014280:Triglycerides; D006903:Hydroxymethylglutaryl CoA Reductases; D025782:Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent