title: Hippocampal synaptophysin immunoreactivity is reduced during natural hypothermia in ground squirrels.
abstract: Natural hypothermia during hibernation results in physiological and behavioral deficits. These changes may be traced at the level of hippocampal signal transduction. We investigated synaptophysin immunoreactivity (SYN-ir) in the hippocampus after short and long periods of hypothermia and short and long periods of euthermy in hibernating ground squirrels. SYN-ir in the stratum lucidum of the hippocampus was transiently reduced during natural hypothermia. Natural hypothermia thus reduces synaptic efficacy. This may play a role in the reduced neuronal connectivity of CA3 pyramidal cell dendrites observed in hibernating ground squirrels.
authors.affiliation: Department of Animal Behavior, University of Groningen, Haren, The Netherlands. a.m.strikjstra@biol.rug.nl
authors.forename: Arjen M
authors.initials: AM
authors.lastname: Strijkstra
authors.forename: Roelof A
authors.initials: RA
authors.lastname: Hut
authors.forename: Martijn C
authors.initials: MC
authors.lastname: de Wilde
authors.forename: Jens
authors.initials: J
authors.lastname: Stieler
authors.forename: Eddy A
authors.initials: EA
authors.lastname: Van der Zee
mesh_terms: D000818:Animals; D015153:Blotting, Western; D006605:Hibernation / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism*; D007035:Hypothermia; D007150:Immunohistochemistry; D012589:Sciuridae; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000378:metabolism; D016708:Synaptophysin / Q000096:biosynthesis*
chemical_list: D016708:Synaptophysin