title: Use of a human polymerized hemoglobin solution as an adjunct to acute normovolemic hemodilution during complex abdominal aortic reconstruction.
abstract: Oxygen-carrying hemoglobin (Hb) solutions are under intense investigation as an alternative to allogeneic red cell transfusion during surgery, with or without acute normovolemic hemodilution. We present a case in which an investigational Hb solution was used as an adjunct to acute normovolemic hemodilution, and as a replacement for surgical blood loss in a patient undergoing complex aortic reconstruction with a large blood loss.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 212877, USA. enorris@jhmi.edu
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Norris
authors.forename: Paul M
authors.initials: PM
authors.lastname: Ness
authors.forename: G Melville
authors.initials: GM
authors.lastname: Williams
mesh_terms: D000368:Aged; D001012:Aorta, Abdominal / Q000601:surgery*; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery; D016063:Blood Loss, Surgical; D001802:Blood Substitutes / Q000627:therapeutic use*; D004562:Electrocardiography; D006438:Hemodilution; D006454:Hemoglobins / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D016343:Monitoring, Intraoperative; D014656:Vascular Surgical Procedures
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins