Different central manifestations in response to electroacupuncture at analgesic and nonanalgesic acupoints in rats: a manganese-enhanced functional magnetic resonance imaging study.
Acupuncture analgesia is an important issue in veterinary medicine. This study was designed to elucidate central modulation effects in response to electroacupuncture (EA) at different acupoints. Manganese-enhanced functional magnetic resonance imaging was performed in Sprague-Dawley rats after sham acupuncture, sham EA, or true EA at somatic acupoints. The acupoints were divided into 3 groups: group 1, analgesic acupoints commonly used for pain relief, such as Hegu (LI 4); group 2, nonanalgesic acupoints rarely used for analgesic effect such as Neiguan (PC 6); and group 3, acupoints occasionally used for analgesia, such as Zusanli (ST 36). Image acquisition was performed on a 1.5-T superconductive clinical scanner with a circular polarized extremity coil. The results showed that there was no neural activation caused by EA at a true acupoint with shallow needling and no electric current (sham acupuncture). When EA at a true acupoint was applied with true needling but no electric current (sham EA), there was only a slight increase in brain activity at the hypothalamus; when EA was applied at a true acupoint with true needling and an electric current (true EA), the primary response at the hypothalamus was enhanced. Also, there was a tendency for the early activation of pain-modulation areas to be prominent after EA at analgesic acupoints as compared with nonanalgesic acupoints. In conclusion, understanding the linkage between peripheral acupoint stimulation and central neural pathways provides not only an evidence-based approach for veterinary acupuncture but also a useful guide for clinical applications of acupuncture.
Chiu
Jen-Hwey
JH
Institute of Traditional Medicine, National Yang-Ming University, Number 155, Section 2, Li-Nong Street, Peitou, Taipei, 112 Taiwan, Republic of China. chiujh@mailsrv.ym.edu.tw
Chung
Mao-Shu
MS
Cheng
Hui-Cheng
HC
Yeh
Tzu-Cheng
TC
Hsieh
Jen-Chuen
JC
Chang
Chung-Yen
CY
Kuo
Wan-Yo
WY
Cheng
Henrich
H
Ho
Low-Tone
LT
D015667:Acupuncture Analgesia / Q000379:methods / Q000592:standards / Q000662:veterinary*; D015669:Acupuncture Points; D000818:Animals; D001921:Brain / Q000502:physiology*; D015671:Electroacupuncture / Q000379:methods / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000662:veterinary*; D008297:Male; D008345:Manganese; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D008345:Manganese