title: Anaphylactic reaction to a dietary supplement containing willow bark.
abstract: OBJECTIVE
  To report a case of anaphylaxis resulting from the use of a willow bark-containing dietary supplement in a patient with a history of an aspirin allergy.
  
  
  METHODS
  A 25-year-old white woman presented to the emergency department of a community teaching hospital with anaphylaxis requiring epinephrine, diphenhydramine, methylprednisolone, and volume resuscitation to which she responded favorably. Medication history revealed that she had ingested 2 capsules of Stacker 2 (NVE Pharmaceuticals, Newton, NJ), a dietary supplement promoted for weight loss, prior to experiencing her initial symptoms. Among other active ingredients, this product contains willow bark. Of significance is that this patient also reported a history of allergy to acetylsalicylic acid. No other causes for anaphylaxis were identified. She continued to receive routine supportive care and the remaining hospital course was uncomplicated.
  
  
  CONCLUSIONS
  Dietary supplements, including herbal products, are used by many individuals who consider them to be inherently safe despite limited regulatory oversight by the Food and Drug Administration. While there may be value to specific botanical ingredients, a potential for adverse effects also exists. The popular product consumed by our patient is used for weight loss and contains willow bark, a source of salicylates. Based on the Naranjo probability scale, it is probable that this case of anaphylaxis was due to this dietary supplement.
  
  
  CONCLUSIONS
  The use of any willow bark-containing dietary supplement may present a risk of anaphylactic reaction to patients with a history of allergy to salicylates. Clinicians need to recognize the potential for adverse effects from dietary supplements.
authors.affiliation: School of Pharmacy, Temple University Health Sciences Center, Philadelphia, PA 19140-5101, USA. joseph.boullata@temple.edu
authors.forename: Joseph I
authors.initials: JI
authors.lastname: Boullata
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: McDonnell
authors.forename: Cynthia D
authors.initials: CD
authors.lastname: Oliva
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced* / Q000628:therapy; D019587:Dietary Supplements / Q000009:adverse effects*; D005260:Female; D006801:Humans; D024301:Plant Bark; D010936:Plant Extracts / Q000009:adverse effects; D032108:Salix / Q000009:adverse effects*
chemical_list: D010936:Plant Extracts