AMPA receptor trafficking and synaptic plasticity: major unanswered questions.
Dynamic movements of AMPA receptors in and out of the postsynaptic membrane account for, at least in part, the expression of NMDA receptor-dependent changes in synaptic efficacy such as long-term potentiation and long-term depression. Recently some of key molecules and subunit rules involved in AMPA receptor trafficking have been identified. In this update article, we try to highlight what we believe to be the major conceptual problems and unanswered questions in this rapidly moving field of neuroscience.
Sheng
Morgan
M
Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA. msheng@mit.edu
Hyoung Lee
Sang
S
D000818:Animals; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology*; D018091:Receptors, AMPA / Q000737:chemistry / Q000378:metabolism*; D013569:Synapses / Q000502:physiology*
D018091:Receptors, AMPA; D018698:Glutamic Acid