title: Bone marrow transplantation in subjects with mental disorders.
abstract: Bone marrow transplantation (BMT) is a critical treatment of malignant illnesses including leukemia and others. Successful achievement of BMT requires the patients to tolerate isolation for several weeks to avoid infections. They are also required to follow several regulations and instructions to survive the treatment because the patients' physical condition is complicated due to the malignant illness, preparatory treatment and transplant of bone marrow from other subjects. These could be a significant challenge for patients with mental disorders. Here the cases are reported of seven leukemia patients who were referred to the Metropolitan Komagome Hospital for BMT from April 1996 through May 2000, who had been suffering from mental disorders, including schizophrenia, bipolar I mood disorder, panic disorder, dysthymic disorder, autistic disorder, and borderline personality disorder, prior to the treatment. The BMT was achieved in six out of the seven subjects; the exception was a subject with borderline personality disorder. Psychiatric treatments, including medication, to improve and maintain mental status appeared to be critical for the achievement of BMT in several patients. Understanding of the status of the malignant disease and the role of BMT was another significant issue. Test admission seemed to be helpful to reduce concerns and anxiety both in the patients and hospital staff.
authors.affiliation: Departments of Psychiatry and Hematology, Tokyo Metropolitan Komagome Hospital and Health Service Center, University of Tokyo, Tokyo, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Akaho
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
authors.forename: Miyo
authors.initials: M
authors.lastname: Yoshino
authors.forename: Katsuko
authors.initials: K
authors.lastname: Hagiya
authors.forename: Hideki
authors.initials: H
authors.lastname: Akiyama
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sakamaki
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000523:psychology*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000523:psychology* / Q000628:therapy*; D008297:Male; D001523:Mental Disorders; D008875:Middle Aged; D010349:Patient Compliance; D018579:Patient Selection; D013315:Stress, Psychological; D016896:Treatment Outcome