title: [Increase of probability of cell loss in the endothelium of blood vessel capillaries in progeny of rats after a low-dose irradiation of one of the parents (electron microscopy study)].
abstract: The total gamma-irradiation of Wistar rats at a dose of 0.25 Gy as well as at higher doses (0.5, 2 and 4.5 Gy) produces in the capillary endothelial cells of myocardium and lung a pronounced, dose-independent increase of the yield of necrotized cells. Similar changes were revealed in the animals, of which one of the parents (a male one day, a female seven days prior to copulation) was irradiated at doses of 0.25 and 0.5 Gy. This effect was observed in all studied descendants. The massive induction of the changes already by low radiation actions and their dose-independence allow considering the revealed effects as a manifestation of peculiar cellular reactions that presumably have epigenetic nature.
authors.affiliation: All-Russian Centre of Emergency and Radiation Medicine, Emercom of Russian, St. Petersburg, 194044 Russia.
authors.forename: P V
authors.initials: PV
authors.lastname: Antonov
authors.forename: I B
authors.initials: IB
authors.lastname: Bychkovskaia
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Nefedov
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Nefedova
authors.forename: G F
authors.initials: GF
authors.lastname: Palyga
authors.forename: R P
authors.initials: RP
authors.lastname: Stepanov
authors.forename: R F
authors.initials: RF
authors.lastname: Fedortseva
authors.forename: D N
authors.initials: DN
authors.lastname: Cherniakova
mesh_terms: D000818:Animals; D002196:Capillaries / Q000166:cytology / Q000528:radiation effects*; D016923:Cell Death; D003331:Coronary Vessels / Q000166:cytology / Q000528:radiation effects; D004730:Endothelium, Vascular / Q000166:cytology / Q000528:radiation effects*; D005260:Female; D005720:Gamma Rays; D008168:Lung / Q000098:blood supply / Q000166:cytology / Q000528:radiation effects; D008297:Male; D018811:Maternal Exposure; D008854:Microscopy, Electron; D009206:Myocardium / Q000166:cytology; D018812:Paternal Exposure; D011829:Radiation Dosage; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors