Urea small molecule agonists on mouse melanocortin receptors.
A series of urea compounds based on the tripeptide Phe-Trp-Lys were synthesized and pharmacologically characterized at the mouse melanocortin receptors. The results include identification of novel melanocortin receptor agonists with potencies ranging from nanomolar to micromolar.
Joseph
Christine G
CG
Department of Medicinal Chemistry, University of Florida, PO Box 100485, Gainesville, FL 32610, USA.
Bauzo
Rayna M
RM
Xiang
Zhimin
Z
Haskell-Luevano
Carrie
C
D000818:Animals; D051379:Mice; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology; D044101:Receptors, Melanocortin / Q000819:agonists*; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
D009842:Oligopeptides; D044101:Receptors, Melanocortin; D014508:Urea