[Whole genome-wide scanning for a large pedigree with matrilineal deafness].
OBJECTIVE
To search responsible nuclear genes for matrilineal non-syndromic deafness.


METHODS
Whole genome-wide scanning was performed to analyze the 365 short tandem repeats in a deaf pedigree with maternal inheritance using DNA pooling strategy. Frequencies of allele in one patient pool were compared with that in one unaffected relative pool as well as in one normal control pool. Linkage analysis was also conducted in some positive loci.


RESULTS
Allele from 45 loci occurred more frequently in the patient pool than that in the unaffected relative pool and the control pool. No linkage was found from any candidate locus investigated.


CONCLUSIONS
45 positive loci obtained from this family may be as the candidate positions for matrilineal non-syndromic deafness.
Xing
G
G
Department of Otorhinolaryngology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China. rad1999@publicl.ptt.js.cn
Yan
M
M
Bu
X
X
D003638:Deafness / Q000235:genetics*; D005260:Female; D005788:Gene Pool; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D010375:Pedigree; D019655:Quantitative Trait, Heritable; D019105:Random Amplified Polymorphic DNA Technique; D020080:Tandem Repeat Sequences