Clinical evaluation of dynamic arc conformal radiotherapy for paraaortic lymph node metastasis.
OBJECTIVE
This study was performed to evaluate the efficacy and safety of dynamic arc conformal radiotherapy, a simple intensity modulated radiation therapy (IMRT), for the treatment of paraaortic lymph node metastases.


METHODS
Twenty-nine patients with paraaortic lymph node metastases were enrolled in this study. The total planned dose was 55-60 Gy. A computed tomography (CT) simulator was used in the treatment planning.


RESULTS
The total radiation dose delivered was 50-63.4 Gy (median 60 Gy). Sixteen of 29 patients showed local tumor shrinkage on CT, and the 2 year in-field recurrence free survival rate was 58%. Acute Grade 1 and Grade 2 gastrointestinal disorders occurred in 31% and 17%, respectively, and acute Grade 2 liver dysfunction occurred in 7%. As a late complication, Grade 1 and Grade 2 liver dysfunction occurred in six patients (21%) and five patients (17%), respectively. There was no renal dysfunction or myelopathy detected.


CONCLUSIONS
Dynamic arc conformal radiotherapy, a simple IMRT, is a safe and effective treatment method for paraaortic lymph node metastasis.
Aoki
Tetsuya
T
Department of Therapeutic Radiology and Oncology, Graduate School of Medicine, Kyoto University, Sakyo, 606-8507, Kyoto, Japan
Nagata
Yasushi
Y
Mizowaki
Takashi
T
Kokubo
Masaki
M
Negoro
Yoshiharu
Y
Takayama
Kenji
K
Mitsumori
Michihide
M
Sasai
Keisuke
K
Hiraoka
Masahiro
M
D001011:Aorta; D003196:Computer Graphics; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000532:radiotherapy; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D011859:Radiography; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000379:methods*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy