Diffuse alopecia in a hemodialysis patient caused by a low-molecular-weight heparin, tinzaparin.
The authors report on a 66-year-old hemodialysis patient who had diffuse alopecia while on anticoagulation treatment to prevent extracorporeal blood clotting with a low- molecular-weight heparin (LMWH), tinzaparin. The alopecia reversed completely when tinzaparin was substituted by another LMWH, enoxaparin. The biopsy findings, the possible mechanisms of heparin's action in the hair roots, and the restoration of the patient's hairs after the discontinuation of tinzaparin are discussed.
Sarris
Evangelos
E
Department of Nephrology, Western Attica General Hospital of Athens, Athens, Greece. ESARRIS1_@HOTMAIL.COM
Tsele
Efrosini
E
Bagiatoudi
Giorgia
G
Salpigidis
Konstantinos
K
Stavrianaki
Danai
D
Kaklamanis
Loukas
L
Siakotos
Marios
M
D000368:Aged; D000505:Alopecia / Q000139:chemically induced*; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D006435:Renal Dialysis; D000078222:Tinzaparin
D005343:Fibrinolytic Agents; D006495:Heparin, Low-Molecular-Weight; D000078222:Tinzaparin