Cortical activation during rhythmic hand movements performed under three types of control: an fMRI study.
Echoplanar fMRI was used to measure changes in cortical activation during the performance of a simple hand movement task under three types of voluntary control. Each of three imaging series alternated a task with rest: passive (in which the experimenter moved the hand), voluntary against low resistance, and voluntary against higher resistance. Contralateral activation was observed in the supplementary motor area (SMA), the primary motor cortex (M1), and the somatosensory cortex (S1) in all three tasks in each subject, whereas ipsilateral activation differed in each cortical region for each task. SMA had the widest prevalence of ipsilateral activation in all three tasks. In the M1, ipsilateral activation was observed in all but 1 subject in the two voluntary tasks but in only a few subjects in the S1 in any of the tasks. Quantitative changes in signal intensity and spatial extent of activation differentiated the voluntary tasks from the passive task and were most pronounced in the S1.
Bernard
R A
RA
Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA. bernard@msu.edu
Goran
D A
DA
Sakai
S T
ST
Carr
T H
TH
McFarlane
D
D
Nordell
B
B
Cooper
T G
TG
Potchen
E J
EJ
D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D005260:Female; D006225:Hand; D006801:Humans; D007699:Kinesthesis / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D011597:Psychomotor Performance; D013003:Somatosensory Cortex / Q000502:physiology*