title: Cytoprotective effects of chalcones from Zuccagnia punctata and melatonin on the gastroduodenal tract in rats.
abstract: The effects of 2',4'-dihydroxychalcone and 2',4'-dihydroxy-3'-methoxychalcone from Zuccagnia punctata Cav. (Fabaceae) and melatonin administration on ethanol-induced gastroduodenal injury were investigated in rats. Both chalcones showed significant preventive effects in treatment with melatonin previous to the necrotising agent. These effects could be due, in part, to the radical scavenging activity of the melatonin.
authors.affiliation: Cátedra de Farmacología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700 San Luis, Argentina.
authors.forename: N
authors.initials: N
authors.lastname: de la Rocha
authors.forename: A O M
authors.initials: AO
authors.lastname: María
authors.forename: J C
authors.initials: JC
authors.lastname: Gianello
authors.forename: L
authors.initials: L
authors.lastname: Pelzer
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D047188:Chalcones; D000431:Ethanol; D007887:Fabaceae; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: C487593:2',4'-dihydroxy-3'-methoxychalcone; D000975:Antioxidants; D047188:Chalcones; D010936:Plant Extracts; C059354:2',4'-dihydroxychalcone; D000431:Ethanol; D002599:Chalcone; D008550:Melatonin