Paucity of Sjogren-like syndrome in a cohort of HIV-1-positive patients in the HAART era. Part II.
OBJECTIVE
This study was performed in order to investigate the prevalence of Sjögren-like syndrome (SLS) in the highly active anti-retroviral therapy (HAART) era in a cohort of HIV-1-positive Greek patients.


METHODS
One hundred and thirty-one unselected patients were screened by the validated European Union (EU) criteria for Sjögren's syndrome. Of the 31 who gave a positive EU-validated questionnaire, 17 consented to undergo minor salivary gland biopsy and other tests.


RESULTS
Only two patients had a positive salivary gland biopsy and both belonged to the non-compliant HAART group, whereas none of the compliant HAART patients had histological findings.


CONCLUSIONS
It is concluded that SLS, the prevalence of which in the pre-HAART era was 7.8%, has disappeared, possibly as a result of the protective action of HAART.
Panayiotakopoulos
G D
GD
Academic Department of Pathophysiology, AIDS Unit, School of Medicine, National and Kapodistrian University of Athens, Greece.
Aroni
K
K
Kyriaki
D
D
Paikos
S
S
Vouyioukas
N
N
Vlachos
A
A
Kontos
A N
AN
Kordossis
T
T
D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D012470:Salivary Glands, Minor / Q000473:pathology; D012859:Sjogren's Syndrome / Q000473:pathology / Q000821:virology*
D019380:Anti-HIV Agents