title: [A case of paraneoplastic syndrome improved following chemoradiotherapy for lung cancer].
abstract: Paraneoplastic neurosyndrome (PNS) is a group of neurological disorders caused by or associated with neoplasms that are not direct effects of the primary tumor or of a metastasis to the involved organs. Chemotherapy, radiotherapy, immunosuppressive therapy, and plasmapheresis have been performed to treat PNS, but improvement of the neurological disorder is rather rare. A 64-year-old man was referred to our hospital with dysesthesia of the extremities and ataxic gait. Small cell lung cancer was diagnosed in another hospital and chemotherapy (CDDP 80 mg/m2 + VP-16 100 mg/m2) was performed. A partial response was obtained with this treatment, but the neurological dysfunction was exacerbated. Three months later, the patient was admitted to our hospital. On treatment with CDDP 80 mg/m2 (day 1) and CPT-11 80 mg/m2 (days 1, 8 and 15) and subsequent radiation therapy (60 Gy), his neurological disorder improved. We consider that neurological symptoms are important signs of malignancy in PNS and that a full course of treatment could improve the neurological disorders.
authors.affiliation: Department of Respiratory Medicine, Nagahama City Hospital, 313 Oinui-cho, Nagahama, Shiga 526-8580, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Tashima
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Kamakari
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Noguchi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ono
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Terada
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D020234:Gait Ataxia / Q000209:etiology / Q000628:therapy; D006801:Humans; D000077146:Irinotecan; D008175:Lung Neoplasms / Q000150:complications* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D020364:Paraneoplastic Polyneuropathy / Q000209:etiology* / Q000628:therapy*; D010292:Paresthesia / Q000209:etiology / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin