Airborne allergic contact dermatitis from 3-iodo-2-propynyl-butylcarbamate at a paint factory.
3-Iodo-2-propynyl-butylcarbamate (IPBC) is a fungicide used in both industrial products and cosmetics. We report the first case of allergic contact dermatitis from airborne exposure to this preservative. A 34-year-old female production worker at a paint factory developed dermatitis on air-exposed skin areas. Patch testing showed a ++ reaction to the preservative IPBC 0.01% in petrolatum. The compound was used as a preservative in wood treatment products manufactured at her work place. Based on animal studies, IPBC is considered safe as a cosmetic preservative. However, widespread use of the chemical might lead to increasing levels of contact allergy, and therefore, close monitoring of IPBC is recommended.
Jensen
Charlotte Devantier
CD
Department of Dermatology, Odense University Hospital, University of Southern Denmark and National Allergy Research Centre, Gentofte, Denmark. charlotte.devantier.jensen@ouh.fyns-amt.dk
Thormann
Jens
J
Andersen
Klaus Ejner
KE
D000328:Adult; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D000485:Allergens / Q000009:adverse effects*; D002219:Carbamates / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D009783:Dermatitis, Occupational / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D010150:Paint / Q000009:adverse effects; D010328:Patch Tests; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*
D000485:Allergens; D002219:Carbamates; D011310:Preservatives, Pharmaceutical; C106572:3-iodo-2-propynylbutylcarbamate