[Giant cell reparative granuloma of the skull].
OBJECTIVE
To investigate the clinical course, histologic feature, diagnosis, differential diagnosis and treatment of giant cell reparative granuloma (GCRG).


METHODS
Three cases of GCRG, which arose in the skull, were collected from 1987 to 1999 and analyzed clinicopathologically.


RESULTS
Two patients had the lesion in the temporal bone and one in the orbit. One patient with GCRG had a recurrence after incomplete surgical resection. Histologically, all of three cases were characterized by fibroblastic proliferation with osteoclast-like giant cell rich areas, hemorrage, and newly formed bone or osteoid trabeculae. GCRG appeared as a typical bony lytic lesion on computed tomography (CT) and as low signal intensity on both T1 and T2 weighted images on magnetic resonance imaging (MRI).


CONCLUSIONS
GCRG is an uncommon nonneoplastic lesion that typically arises in mandible and maxilla and its involvement in skull is rare. Although behaves benignly, GCRG may be locally aggresive. It is usually misdiagnosed for a giant cell tumor (GCT). Diagnosis of GCRG is based on typical histologic features as well as clinical information. Complete surgical resection is believed to be the most suitable treatment for GCRG and long-term follow-up by CT scanning is essential.
Liu
J
J
Department of Otorhinolaryngology, PLA General Hospital, Beijing 100853, China. liujunent@263.net
Zhong
D
D
Liu
L
L
Sun
C
C
Han
D
D
Yang
W
W
D000328:Adult; D000368:Aged; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006101:Granuloma, Giant Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009915:Orbit / Q000601:surgery*; D013701:Temporal Bone / Q000601:surgery*