IQGAP proteins are integral components of cytoskeletal regulation.
IQGAP1 is a scaffolding protein that binds to a diverse array of signalling and structural molecules. By interacting with its target proteins, human IQGAP1 participates in multiple cellular functions, including Ca(2+)/calmodulin signalling, cytoskeletal architecture, CDC42 and Rac signalling, E-cadherin-mediated cell-cell adhesion and beta-catenin-mediated transcription. Yeast IQGAP homologues are important regulators of cellular morphogenesis because they are required for budding and cytokinesis. Here we discuss the structure and function of IQGAP1 as a member of the family of IQGAP proteins and summarize the current knowledge about IQGAP1 and IQGAP2. Collectively, these data reveal that IQGAP1 is a fundamental regulator of cytoskeletal function.
Briggs
Michael W
MW
Brigham and Women's Hospital, Thorn 530, 75 Francis Street, Boston, MA 02115, USA.
Sacks
David B
DB
D000818:Animals; D002455:Cell Division; D003598:Cytoskeletal Proteins / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D008840:Microfilament Proteins / Q000737:chemistry* / Q000502:physiology*; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism; D014158:Transcription, Genetic; D051176:beta Catenin; D020703:ras GTPase-Activating Proteins
C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; C101203:IQ motif containing GTPase activating protein 1; D008840:Microfilament Proteins; D015534:Trans-Activators; D051176:beta Catenin; D020703:ras GTPase-Activating Proteins