Orbitofrontal cortex and dynamic filtering of emotional stimuli.
Event-related potentials (ER) were recorded in response to mildly aversive somatosensory and auditory stimuli. Patients with orbitofrontal lesions exhited enhanced ERPs (i.e., P3 amplitudes), as compared with control subjects. Moreover, these patients did not habituate to somatoensory stimuli across blocks of trials. The results were specific to orbitofrontal damage, since patients with damage to the dorsolateral prefontal cortex did not exhibit enhanced P3 amplitudes. These findings suggest damage to the orbitofrontal cortex impairs the ability to modulate or inhibit neural responses to aversive stimuli. The findings are couched in terms of dynamic filtering theory, which suggests that the orbitofrontal cortex is involved in the selection and active inhibition of neural circuits associated with emotional responses.
Rule
Randall R
RR
University of California Berkely, California 94720-1650, USA.
Shimamura
Arthur P
AP
Knight
Robert T
RT
D000328:Adult; D000368:Aged; D001143:Arousal / Q000502:physiology; D001930:Brain Injuries / Q000503:physiopathology; D004644:Emotions / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006185:Habituation, Psychophysiologic / Q000502:physiology; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008606:Mental Processes / Q000502:physiology*; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000503:physiopathology*