Immunity to Trichuris muris in the laboratory mouse.
Of all the laboratory models of intestinal nematode infection, Trichuris muris in the mouse is arguably the most powerful. This is largely due to the fact that the ability to expel this parasite is strain dependent. Thus, most mouse strains readily expel T. muris. However certain mouse strains, and indeed some individuals within particular mouse strains, are unable to mount a protective immune response and harbour long term chronic infections. This unique model thus presents an opportunity to examine the immune events underlying both resistance to infection and persistent infection within the same host species, and in some cases, the same host strain.
Else
K J
KJ
School of Biological Sciences, University of Manchester, 3.239 Stopford Building, Oxford Road, Manchester M13 9PT, UK. kathryn.j.else@man.ac.uk
deSchoolmeester
M L
ML
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D006790:Host-Parasite Interactions; D007378:Interleukins / Q000276:immunology; D007411:Intestinal Diseases, Parasitic / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology / Q000469:parasitology; D051379:Mice; D008815:Mice, Inbred Strains / Q000469:parasitology*; D023421:Models, Animal; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014257:Trichuriasis / Q000276:immunology*; D014258:Trichuris / Q000276:immunology / Q000502:physiology*
D000947:Antigens, Helminth; D007378:Interleukins