title: Surveillance in stage I testicular cancer.
abstract: Treatment results on 695 stage I testicular cancer patients followed with surveillance are described. Seminoma (SGCT) was present in 394 patients and nonseminoma (NSGCT) in 301 patients. Relapses were detected in 155 patients (22%), in 69 patients with SGCT (17%) and 86 with NSGCT (29%). In patients with vascular invasion, relapse was detected in 54% of patients with NSGCT and 38% of patients with SGCT. Time to relapse was median 13 months (range 1 to 84 months) for SGCT and 5 months (range 1 to 171 months) for NSGCT. Forty-nine percent of relapses in SGCT patients were seen within the first year, 87% of the relapses were diagnosed within the first two years, and 98% of the relapses were detected within 5 years. The figures for NSGCT were 80%, 89% and 95%, respectively. Forty-five patients had carcinoma in situ in the contralateral testis, 62% had this together with a seminoma in the other testis. Ten patients died during the follow-up period. None of these deaths were caused by the germ cell tumour or the treatment. The overall survival for patients with stage I disease is 98.6%, and the cause specific survival 100%.
authors.affiliation: Department of Oncology, Rigshospitalet, Copenhagen. gedske@rh.dk
authors.forename: Gedske
authors.initials: G
authors.lastname: Daugaard
authors.forename: Peter Meidahl
authors.initials: PM
authors.lastname: Petersen
authors.forename: Mikael
authors.initials: M
authors.lastname: Rørth
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D015331:Cohort Studies; D003131:Combined Modality Therapy; D003718:Denmark; D018237:Germinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000473:pathology; D009919:Orchiectomy; D010808:Physical Examination; D011159:Population Surveillance; D011859:Radiography; D018239:Seminoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D015996:Survival Rate; D013736:Testicular Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor