title: Immunological and endocrinological studies on lymphocyte subpopulation and medical treatment for infertility in patients with endometriosis.
abstract: We investigated the relationship between interleukin-6 (IL-6) levels and subset profiles of T lymphocyte (T-cell) and macrophage in peritoneal fluid (PF) with or without endometriosis (EM). IL-6 levels in PF with EM were significantly higher than those without EM. IL-6 producing cells with EM were analyzed in each activated mature T-cell (CD3+CD69+) and macrophage (CD14+) were 0.5 and 3.5%, respectively, whereas it was mostly negative in those without EM. Cytotoxic T-cell (CD8+CD11b-) profiles in PF with EM were also quiet different from those without EM. Cellular immunity in the peripheral blood did not change during the course of IVF-ET cycles, although plasma levels of ovarian steroid hormones significantly increased comparing with that in normal ovarian cycles. Cytotoxic T-cell type 1 (Tc1) profiles might be useful predictive values in the pregnancy outcome for infertile patients with EM.
authors.affiliation: Department of Obstetrics and Gynecology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Furuya
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Murakami
authors.forename: Noriko
authors.initials: N
authors.lastname: Makimura
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsuda
authors.forename: Kanoko
authors.initials: K
authors.lastname: Ikou
authors.forename: Keiko
authors.initials: K
authors.lastname: Saito
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shibazaki
authors.forename: Utako
authors.initials: U
authors.lastname: Fukui
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Mizumoto
authors.forename: Susumu
authors.initials: S
authors.lastname: Tokuoka
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nagata
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kikuchi
mesh_terms: D001202:Ascitic Fluid / Q000166:cytology / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D004715:Endometriosis / Q000150:complications / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D015850:Interleukin-6 / Q000378:metabolism; D008264:Macrophages / Q000276:immunology; D011247:Pregnancy; D011256:Pregnancy Outcome; D027724:Reproductive Techniques, Assisted; D013256:Steroids / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D013256:Steroids