[Cerebral ischemic events and anti-cancer therapy].
Antineoplastic agents have been associated with cerebral hemorrhage, infarction and cerebral venous thrombosis. Infarctions have been reported in association with L-asparaginase, cisplatinium, methotrexate and 5-fluro-uracil. The mechanisms by which antineoplastic agents may lead to stroke include endothelium toxicity and abnormalities of coagulation factors.
El Amrani
M
M
Service de Neurologie, Hôpital Lariboisière, Paris.
Aidi
S
S
Amarenco
P
P
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001215:Asparaginase / Q000009:adverse effects; D002545:Brain Ischemia / Q000139:chemically induced*; D002543:Cerebral Hemorrhage / Q000139:chemically induced; D002648:Child; D002675:Child, Preschool; D002945:Cisplatin / Q000009:adverse effects; D004198:Disease Susceptibility; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects; D006131:Growth Inhibitors / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications
D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D001215:Asparaginase; D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate