Genetic vulnerability following traumatic brain injury: the role of apolipoprotein E.
Apolipoprotein E (APOE) is thought to be responsible for the transportation of lipids within the brain, maintaining structural integrity of the microtubule within the neurone, and assisting with neural transmission. Possession of the APOE epsilon4 allele has also been shown to influence neuropathological findings in patients who die from traumatic brain injury, including the accumulation of amyloid beta protein. Previous clinical studies reporting varying outcome severities of traumatic brain injury, including cognitive and functional recovery, all support the notion that APOE epsilon4 allele possession is associated with an unfavourable outcome. Evidence from experimental and clinical brain injury studies confirms that APOE plays an important role in the response of the brain to injury.
Nathoo
N
N
Department of Neurosurgery, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, 44195 Ohio, USA. nathoon@ccf.org
Chetty
R
R
van Dellen
J R
JR
Barnett
G H
GH
D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics* / Q000502:physiology; D001930:Brain Injuries / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D011379:Prognosis
D001057:Apolipoproteins E