title: [Study on pharmacology of ultra-fine particles compound Rehmannia].
abstract: OBJECTIVE
  To observe pharmacological difference between ultra-fine particles of six ingredient Rehmannia pill and traditional six ingredient Rehmannia pill.
  
  
  METHODS
  Pharmacokinetic index was measured by death rate, and pharmacology actions were compared by anti-fatigue, hypoglycemic, clearance rate of charcoal particle, hypoxia resistance and serum hemolysin concentration experiment.
  
  
  RESULTS
  Dose-effection was significant and pharmacology actions were more than traditional six ingredient Rehmannia pill in six ingredient Rehmannia pill.
  
  
  CONCLUSIONS
  Ultra-fine particles of six ingredient Rehmannia pill are better than traditional six ingredient Rehmannia pill in bioavailability and pharmacology actions, and the weight of pill is reduced while efficacy is enhenced by ultra-fine particles.
authors.affiliation: Pharmaceutical College of Henan University, Kaifeng 475001, Henan, China. song0378@fm365.com
authors.forename: Li-li
authors.initials: LL
authors.lastname: Song
authors.forename: Gang-jun
authors.initials: GJ
authors.lastname: Du
authors.forename: Bing-yi
authors.initials: BY
authors.lastname: Fan
authors.forename: Da-lu
authors.initials: DL
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001682:Biological Availability; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics / Q000494:pharmacology*; D005221:Fatigue / Q000188:drug therapy; D006460:Hemolysin Proteins / Q000097:blood; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D011208:Powders; D032267:Rehmannia / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D006460:Hemolysin Proteins; D007004:Hypoglycemic Agents; C042579:Liuwei Dihuang Decoction; D011208:Powders