title: Mixed chiral stationary phase containing modified resorcinarene and beta-cyclodextrin selectors bonded to a polysiloxane for enantioselective gas chromatography.
abstract: Both a resorcinarene with pendant L-valine diamide groups (used as hydrogen-bonding selector) and a permethylated beta-cyclodextrin (used as inclusion-type selector) were chemically bonded to poly(hydromethyl)dimethylsiloxane in a one-pot reaction via Pt-catalyzed alkene hydrosilylation. This novel mixed chiral stationary phase (mixCSP) named Chirasil-Calixval-Dex resembles a combination of the known chiral stationary phases (CSPs) Chirasil-Calixval and Chirasil-Dex and it was used successfully in enantioselective gas chromatography toward a unified enantioselective GC separation system. It is demonstrated that Chirasil-Calixval-Dex retains the individual enantioselectivites of the single components. Thus the enantiomers of apolar hydrocarbons as well as polar amino acid derivatives can be separated with the mixed CSP.
authors.affiliation: Institute of Organic Chemistry, Auf der Morgenstelle 18, D-72076 Tübingen, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Ruderisch
authors.forename: Jens
authors.initials: J
authors.lastname: Pfeiffer
authors.forename: Volker
authors.initials: V
authors.lastname: Schurig
mesh_terms: D047250:Calixarenes; D002849:Chromatography, Gas / Q000295:instrumentation*; D003505:Cyclodextrins / Q000737:chemistry*; D006860:Hydrogen Bonding; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry*; D012833:Siloxanes / Q000737:chemistry*; D013237:Stereoisomerism; D047392:beta-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D012833:Siloxanes; D047392:beta-Cyclodextrins; C466160:resorcinarene; D047250:Calixarenes; D010649:Phenylalanine; C031215:betadex