[Study on pharmacology of ultra-fine particles compound Rehmannia].
OBJECTIVE
To observe pharmacological difference between ultra-fine particles of six ingredient Rehmannia pill and traditional six ingredient Rehmannia pill.


METHODS
Pharmacokinetic index was measured by death rate, and pharmacology actions were compared by anti-fatigue, hypoglycemic, clearance rate of charcoal particle, hypoxia resistance and serum hemolysin concentration experiment.


RESULTS
Dose-effection was significant and pharmacology actions were more than traditional six ingredient Rehmannia pill in six ingredient Rehmannia pill.


CONCLUSIONS
Ultra-fine particles of six ingredient Rehmannia pill are better than traditional six ingredient Rehmannia pill in bioavailability and pharmacology actions, and the weight of pill is reduced while efficacy is enhenced by ultra-fine particles.
Song
Li-li
LL
Pharmaceutical College of Henan University, Kaifeng 475001, Henan, China. song0378@fm365.com
Du
Gang-jun
GJ
Fan
Bing-yi
BY
Zhang
Da-lu
DL
D000818:Animals; D001682:Biological Availability; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics / Q000494:pharmacology*; D005221:Fatigue / Q000188:drug therapy; D006460:Hemolysin Proteins / Q000097:blood; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D011208:Powders; D032267:Rehmannia / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D006460:Hemolysin Proteins; D007004:Hypoglycemic Agents; C042579:Liuwei Dihuang Decoction; D011208:Powders