Low-resolution molecular replacement using a six-dimensional search.
A parallel-aware program MPI_FSEARCH has been implemented to perform molecular replacement using an exhaustive six-dimensional search. In particular, the program can be used to deal with diffraction data at very low resolution (d > 10 A) that would normally not be appropriate for other molecular-replacement programs such as AMoRe and CNS. Although an envelope constructed from a PDB (Protein Data Bank) file was tested in the present study, the program can be used to perform low-resolution molecular replacement with an envelope derived from various sources such as electron microscopy or small-angle solution X-ray scattering.
Liu
Qun
Q
MacCHESS at Cornell High Energy Synchrotron Source, Cornell University, Ithaca, NY 14853-8001, USA.
Weaver
Arthur J
AJ
Xiang
Tao
T
Thiel
Daniel J
DJ
Hao
Quan
Q
D010832:6-Phytase / Q000737:chemistry; D001232:Aspergillus fumigatus / Q000201:enzymology; D003198:Computer Simulation; D018360:Crystallography, X-Ray / Q000379:methods*; D008958:Models, Molecular; D008968:Molecular Conformation; D011506:Proteins / Q000737:chemistry*; D012984:Software
D011506:Proteins; D010832:6-Phytase