title: Population pharmacokinetics of carbamazepine in Chinese epilepsy patients.
abstract: OBJECTIVE
  To investigate the pharmacokinetic profile of carbamazepine (CBZ) in Chinese epilepsy patients.
  
  
  METHODS
  Serum samples through concentrations at steady state (n = 687) were collected prospectively from 585 patients during routine clinical care. Data were analyzed by the non-linear mixed-effect modeling (NONMEM) technique with a one-compartment model of first-order absorption and elimination.
  
  
  RESULTS
  The important determinants of clearance (CL) were total body weight (TBW); dose; patient age over 65 years (E); and comedication with phenytoin (PHT), phenobarbital (PB), or valproic acid (VPA) when VPA daily dose was greater than 18 mg/kg. The final pharmacokinetic model for relative CL and apparent distribution volume (V) were: Equation
  
  
  CONCLUSIONS
  A population pharmacokinetic model was proposed to estimate the individual CL for Chinese patients receiving CBZ in terms of patient's dose, TBW, and comedications to establish a priori dosage regimens.
authors.affiliation: Hua Shan Hospital, Fu Dan University, Shanghai, People's Republic of China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Jiao
authors.forename: Ming-Kang
authors.initials: MK
authors.lastname: Zhong
authors.forename: Xiao-Jin
authors.initials: XJ
authors.lastname: Shi
authors.forename: Min
authors.initials: M
authors.lastname: Hu
authors.forename: Jing-Hua
authors.initials: JH
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002220:Carbamazepine / Q000097:blood* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D002681:China; D016001:Confidence Intervals; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D011446:Prospective Studies; D015203:Reproducibility of Results
chemical_list: D002220:Carbamazepine