[Preliminary clinical study of application of cyntridini triphosphatis and dexamethasone in treatment of sudden deafness].
OBJECTIVE
To investigate the effect of application of cytridini triphosphatis (CTP) combined with dexamethasone on sudden deafness.


METHODS
Two-hundred and seven patients (312 ears) with sudden deafness were randomly divided into CTP group (n = 159 ears) and control group (n = 153 ears). Besides intravenous administration of CTP, another treatments in CTP group were the same as that in control group including hyperbaric oxygen, vasodilator, energy preparation such as ATP, CoA and dexamethasone (DXM).


RESULTS
The hearing threshold was (75.56 +/- 30.24) dB HL in CTP group and (72.50 +/- 40.50)dB HL in control group (P > 0.05) before treatment. The average value of the hearing threshold after treatment was decreased by (50.08 +/- 21.47) dB HL in CTP group and (19.45 +/- 19.12) dB in control group(P < 0.05), respectively.


CONCLUSIONS
The application of CTP combined with DXM can significantly improve the effect of treatment on sudden deafness and CTP may enhance the recovery rate in the patients with sudden deafness, which was much higher than that treated by the traditional methods. However, the mechanism of the effect of CTP coupled with DXM is still unknown and further study is necessary.
Luo
Wenlong
W
Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400010, China. wenlongluo@163.net
Liu
Shixi
S
Liang
Chuanyu
C
Liu
Yang
Y
Zhou
Cuiying
C
Cao
Qian
Q
Su
Junbo
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D001301:Audiometry, Pure-Tone; D003570:Cytidine Triphosphate / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D003639:Hearing Loss, Sudden / Q000188:drug therapy / Q000628:therapy*; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D008875:Middle Aged
D003570:Cytidine Triphosphate; D003907:Dexamethasone