Differential activation on fMRI of monozygotic twins discordant for AD.
This is the first report of fMRI in monozygotic twins discordant for AD. FMRI brain activation patterns were examined during visuospatial and verbal working memory tasks. The affected twin had greater parietal involvement bilaterally during both working memory tasks and reduced left dorsolateral prefrontal cortex activity on the visuospatial memory task. Thus, fMRI may identify additional brain regions recruited in patients with AD to perform a given cognitive task.
Lipton
A M
AM
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Texas 75390-9070, USA. anne.lipton@utsouthwestern.edu
McColl
R
R
Cullum
C M
CM
Allen
G
G
Ringe
W K
WK
Bonte
F J
FJ
McDonald
E
E
Rubin
C D
CD
D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D004200:Diseases in Twins; D006720:Homozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000235:genetics / Q000473:pathology; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D011877:Radionuclide Imaging; D016037:Single-Blind Method; D013382:Subtraction Technique; D014430:Twins, Monozygotic; D014706:Verbal Learning
D053327:Apolipoprotein E4; D001057:Apolipoproteins E