Differential molecular profiling between skin carcinomas reveals four newly reported genes potentially implicated in squamous cell carcinoma development.
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are skin tumors with different invasive potential. In this work, we analysed mRNA differential expression between seven BCC and five SCC and their normal skin counterparts using 1176 cDNA macroarrays and verification by RT-PCR to identify genes modulated in each tumor type. We identified 37 genes commonly modulated in both tumors and four genes specifically modulated in SCC. Among these latter RhoC and EMMPRIN genes seem to be of particular interest and could participate in SCC aggressivity.
Marionnet
Claire
C
INSERM U532, Hôpital Saint-Louis, Paris, France.
Lalou
Claude
C
Mollier
Karine
K
Chazal
Marjorie
M
Delestaing
Gisele
G
Compan
Delphine
D
Verola
Olivier
O
Vilmer
Catherine
C
Cuminet
Jerome
J
Dubertret
Louis
L
Basset-Séguin
Nicole
N
D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger / Q000378:metabolism; D012878:Skin Neoplasms / Q000235:genetics*
C063306:HINT1 protein, human; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger