Absence of linkage between the interleukin-6 gene (-174 G/C) polymorphism and migraine.
To assess the role of interleukin-6 (IL-6) in migraine, we analyzed the -174 G/C IL-6 gene polymorphism in 268 patients with migraine and 305 controls. No significant difference in the distribution of IL-6 genotypes (chi(2)=0.601, P=0.74) and allelic frequencies (chi(2)=0.024, P=0.876) was found. When patients were subdivided into subgroups (migraine with aura, migraine without aura and mixed headaches), IL-6 alleles were similarly distributed. Comparison of the clinical features of the disease with the -174 G/C IL-6 genotypes showed no significant difference. In conclusion, we found no significant association between the -174 G/C IL-6 polymorphism and the occurrence or the clinical features of migraine.
Rainero
Innocenzo
I
Neurology III--Headache Center, Department of Neuroscience, University of Torino, Via Cherasco 15-10126, Turin, Italy. irainero@molinette.piemonte.it
Salani
Giuliana
G
Valfrè
Walter
W
Savi
Lidia
L
Rivoiro
Chiara
C
Ferrero
Margherita
M
Pinessi
Lorenzo
L
Grimaldi
Luigi M E
LM
D000328:Adult; D000483:Alleles; D015331:Cohort Studies; D004247:DNA / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000235:genetics*; D020325:Migraine with Aura / Q000235:genetics; D020326:Migraine without Aura / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D015850:Interleukin-6; D004247:DNA