title: The results of 15 years of consistent strategy in treating antenatally suspected pelvi-ureteric junction obstruction.
abstract: OBJECTIVE
  To determine how to select patients for surgery among those with antenatally detected pelvi-ureteric junction (PUJ) obstruction.
  
  
  METHODS
  The study comprised 100 consecutive children with antenatally detected suspected unilateral PUJ obstruction and a normal contralateral kidney. The correct diagnosis was made using postnatal ultrasonography, intravenous urography and renal scintigraphy, the last also being used for the follow-up.
  
  
  RESULTS
  Four patients had poor function in the hydronephrotic kidney, treated in three by nephrectomy; 61 had normal function in the hydronephrotic kidney, with 49 followed for 1-10 years with no change in kidney function and no symptoms. Twelve patients in this group had later surgery (at 0.7-8 years old) because of pyelonephritis (four), pain and/or renal functional impairment (eight, three of whom had normal function afterward). Thirty-five patients had moderately impaired function of the hydronephrotic kidney; 29 had primary surgery at a median age of 4 months. The median hydronephrotic renal function increased from 32% before to 42% after surgery, with 15 kidneys having normal function. In one other patient the kidney was lost before surgery. Five other patients were initially treated conservatively and the hydronephrotic renal function increased from 32% to 35% at the 1-year follow-up, significantly less than in the surgical group. The overall operative complication rate was 4%.
  
  
  CONCLUSIONS
  With our management programme more than half the patients can avoid surgery in childhood. Although the follow-up was intense there was moderate and irreversible functional kidney deterioration in 5%. In contrast, after successful reconstructive surgery, only a few follow-up procedures causing possible discomfort to the child are needed in most. The risk of surgical complications cannot be neglected. The present results are useful for advising parents deciding whether their antenatally detected hydronephrotic child should undergo surgery or not.
authors.affiliation: Department of Paediatric Surgery, Rigshospitalet, University of Copenhagen, Denmark. joergenrh01450thorup@rh.dk
authors.forename: J
authors.initials: J
authors.lastname: Thorup
authors.forename: R
authors.initials: R
authors.lastname: Jokela
authors.forename: D
authors.initials: D
authors.lastname: Cortes
authors.forename: O H
authors.initials: OH
authors.lastname: Nielsen
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006869:Hydronephrosis / Q000503:physiopathology / Q000601:surgery*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009392:Nephrectomy / Q000379:methods*; D011247:Pregnancy; D016216:Ultrasonography, Prenatal; D014517:Ureteral Obstruction / Q000151:congenital / Q000000981:diagnostic imaging / Q000601:surgery*