[Relationship of I/D polymorphism of angiotensin converting enzyme gene with hypertension in Xinjiang Kazakh isolated group].
OBJECTIVE
To investigate whether the insertion/deletion(I/D) polymorphism in the angiotensin converting enzyme(ACE) gene is associated with essential hypertension in Xinjiang Kazakh isolated population.


METHODS
The study covered 201 hypertensives and 151 normotensive controls in Xinjiang Barlikun Kazakh population. The I/D polymorphism of ACE gene was determined by polymerase chain reaction.


RESULTS
The frequencies of D and I in the hypertensive group (0.44 and 0.56, respectively) were not significantly different from the controls(0.39 and 0.61, respectively, P=0.16). The frequencies of ACE genotypes of DD, ID, and II were 0.18, 0.52, 0.30 in hypertensives respectively and 0.17, 0.43, 0.40 in control group respectively. There was no significant difference in genotypes between hypertensive group and normotensive group (P=0.14).


CONCLUSIONS
The results suggested that the I/D polymorphism of ACE gene might not be associated with hypertension in the Kazakh population of Xinjiang Barlikun area.
Wang
Xiao-feng
XF
Department of Cardiac Internal Medicine, the First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, 830054 PR China. wxfjxy22103@hotmail.com
Wang
Shi-zhen
SZ
Lin
Ren-yong
RY
Cheng
Zu-heng
ZH
Ding
Jian-bin
JB
Jia
Mi-la
ML
Wen
Hao
H
Wu
Gui-zhen
GZ
Lu
Xiao-mei
XM
D044466:Asian People / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics; D002681:China / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D054643:INDEL Mutation; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D044382:Population Groups
D007703:Peptidyl-Dipeptidase A