Tissue engineering therapy for cardiovascular disease.
The present treatments for the loss or failure of cardiovascular function include organ transplantation, surgical reconstruction, mechanical or synthetic devices, or the administration of metabolic products. Although routinely used, these treatments are not without constraints and complications. The emerging and interdisciplinary field of tissue engineering has evolved to provide solutions to tissue creation and repair. Tissue engineering applies the principles of engineering, material science, and biology toward the development of biological substitutes that restore, maintain, or improve tissue function. Progress has been made in engineering the various components of the cardiovascular system, including blood vessels, heart valves, and cardiac muscle. Many pivotal studies have been performed in recent years that may support the move toward the widespread application of tissue-engineered therapy for cardiovascular diseases. The studies discussed include endothelial cell seeding of vascular grafts, tissue-engineered vascular conduits, generation of heart valve leaflets, cardiomyoplasty, genetic manipulation, and in vitro conditions for optimizing tissue-engineered cardiovascular constructs.
Nugent
Helen M
HM
Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Building 16, Room 325, Cambridge, Mass 02139, USA. ellenugent@attbi.com
Edelman
Elazer R
ER
D000818:Animals; D018421:Cardiomyoplasty / Q000379:methods; D002318:Cardiovascular Diseases / Q000628:therapy*; D017690:Cell Transplantation / Q000379:methods; D015316:Genetic Therapy / Q000379:methods; D006349:Heart Valve Diseases / Q000628:therapy; D006801:Humans; D009204:Myocardial Revascularization / Q000379:methods; D023822:Tissue Engineering / Q000379:methods*