Antifungal activity of sterols and triterpenes isolated from Ganoderma annulare.
Three sterols, 5alpha-ergost-7-en-3beta-ol, 5alpha-ergosta-7,22-dien-3beta-ol and 5,8-epidioxy-5alpha,8alpha-ergosta-6,22-dien-3beta-ol and five triterpenes, applanoxidic acids A, C, F, G and H, have been isolated from Ganoderma annulare. The applanoxidic acids A, C and F were found to inhibit the growth of the fungi Microsporum cannis and Trichophyton mentagrophytes at concentrations of 500 to 1000 microg/ml.
Smania
E F A
EF
Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Catarina, Florianopolis, SC 88040-900, Brazil.
Delle Monache
F
F
Smania
A
A
Yunes
R A
RA
Cuneo
R S
RS
D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D032902:Ganoderma; D006801:Humans; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013261:Sterols / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D014249:Trichophyton / Q000187:drug effects*; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D014934:Wood
D000935:Antifungal Agents; D010936:Plant Extracts; D013261:Sterols; D014315:Triterpenes