[Protective effect of daizein on apoptosis cells of nasal mucosas in ovariectomized rats].
OBJECTIVE
To study the protective effect of daizein on apoptosis cells of atrophic nasal mucosas in ovariectomized rats.


METHODS
Sixty rats were divided into four groups as contrary, ovariectomized, ovariectomized + nylestriol (O + N) and ovariectomized + daizein (O + D), each with 15 rats. Earlier apotosis cells of nasal mucosas taken from nasal septum were measured with flow cytometry.


RESULTS
Compared with contrary group, the number of apoptosis cells of mucosas increased after being ovariectomized, the number of apoptosis cells of mucosas in O + N and O + D groups didn't change.


CONCLUSIONS
Estrogen replacement and daizein might have effects on protecting cells of mucosas from lacking of estrogen by decreasing apoptosis cells in ovariectomized rats.
Qi
Ben-ming
BM
Department of Otorhinolaryngology, First People's Hospital of Yunnan Province, Kunming 650001, China. qibenming@21cn.com
Tian
Xing-hua
XH
Wang
Ji-bao
JB
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001284:Atrophy; D004847:Epithelial Cells / Q000473:pathology*; D005260:Female; D007529:Isoflavones / Q000494:pharmacology*; D009297:Nasal Mucosa / Q000473:pathology*; D010052:Ovariectomy; D011800:Quinestrol / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D007529:Isoflavones; C004742:daidzein; C010722:nylestriol; D011800:Quinestrol