Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome.
The systemic inflammatory response syndrome (SIRS) is a major cause of morbidity and mortality, and is thought to be due to an over-amplification of an inflammatory response. The Toll-like receptor 4 ( TLR4 ) Asp-299-->Gly polymorphism has been shown to reduce lipopolysaccharide responsiveness. We examined whether this TLR4 polymorphism is associated with severity of SIRS. A trend was found between the minor allele and mortality in SIRS (odds ratio of 4.3; P =0.076), suggesting a role for TLR4 signalling in the severity of SIRS.
Child
N J A
NJ
Human Genetics Division and Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, Southampton, UK.
Yang
I A
IA
Pulletz
M C K
MC
de Courcy-Golder
K
K
Andrews
A-L
AL
Pappachan
V J
VJ
Holloway
J W
JW
D018806:APACHE; D000328:Adult; D005838:Genotype; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000235:genetics*; D018746:Systemic Inflammatory Response Syndrome / Q000235:genetics*; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors
D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors