Topical therapy for actinic keratoses, I: 5-Fluorouracil and imiquimod.
Actinic keratoses (AKs) are evolving, malignant cutaneous neoplasms. AKs can be treated with physical or destructive methods and with topical therapies. This article is the first in a 2-part series that will review current topical therapeutic options for AKs. Several topical treatment options offer some significant benefit for the alleviation of these lesions. Therapies include 5-fluorouracil, imiquimod, diclofenac, colchicine, and retinoids. The first part of this review will focus on topical 5-fluorouracil and imiquimod.
Tutrone
William D
WD
University of Vermont, Burlington, USA. william.tutrone@uvm.edu
Saini
Ritu
R
Caglar
Selin
S
Weinberg
Jeffrey M
JM
Crespo
Jorge
J
D000279:Administration, Cutaneous; D000634:Aminoquinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D000077271:Imiquimod; D007642:Keratosis / Q000188:drug therapy* / Q000473:pathology; D011230:Precancerous Conditions / Q000188:drug therapy / Q000473:pathology; D016032:Randomized Controlled Trials as Topic; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology
D000634:Aminoquinolines; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D000077271:Imiquimod; D005472:Fluorouracil