title: [Study on the compatibility of composite herbal medicines of the lingguizhugan decoction].
abstract: OBJECTIVE
  To study the compatibility of composite herbal medicines of the Ling Gui Zhu Gan Decoction.
  
  
  METHODS
  Ethanol extract test solutions of the different combinations were prepared according to the orthogonal layout L16(4(5)). Pharmacologic experiments, such as the time of surviving of mice in shortage of oxygen in regular air pressure, the antagonizing effect on arrhythmia induced by chloroform and diuresis were carried out with the solutions. Variance analysis, canonical correlation and stepwise regression analysis were applied to interrelate the amount of each drug and the pharmacologic data.
  
  
  RESULTS
  The results confirmed that Fuling and Guizhi are the basis, while Baizhuand Gancao are the adjuvans, which is conformed to the theory of TCM.
  
  
  CONCLUSIONS
  This study provides a significant try for studying the compatibility of composite herbal medicines.
authors.affiliation: Shenyang Pharmaceutical University, Shenyang 110015, Liaoning, China.
authors.forename: Zong-hua
authors.initials: ZH
authors.lastname: Song
authors.forename: Shu-jia
authors.initials: SJ
authors.lastname: Dai
authors.forename: Hui-qin
authors.initials: HQ
authors.lastname: Li
authors.forename: Kai-shun
authors.initials: KS
authors.lastname: Bi
authors.forename: Dong
authors.initials: D
authors.lastname: Feng
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D004232:Diuretics / Q000494:pharmacology; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use; D005260:Female; D000860:Hypoxia / Q000188:drug therapy; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry; D014693:Ventricular Fibrillation / Q000188:drug therapy
chemical_list: D000889:Anti-Arrhythmia Agents; D004232:Diuretics; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C457640:ling-gui-zhu-gan decoction