[Presence of hepatitis C virus in renal tissue in membranoproliferative glomerulonephritis and cryoglobulinemia].
Although hepatitis C virus infection has been documented in several extrahepatic diseases, the deposition of HCV RNA in glomerular structures has proved to be difficult to demonstrate. We report a patient with membranoproliferative glomerulonephritis, type III circulating cryoglobulins and hepatitis C virus infection with detection of HCV RNA in serum, cryoprecipitate and renal tissue using specific RT-PCR technique. These data confirm that HCV could have a direct role in renal damage.
Tormo
A
A
Servicios de Nefrología, Anatomía Patológica e Inmunología, Hospital General Universitario de Alicante.
Rivera
F
F
Muñoz
C
C
Trigueros
M
M
D000368:Aged; D003449:Cryoglobulinemia / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000821:virology*; D003450:Cryoglobulins / Q000032:analysis; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology / Q000473:pathology / Q000821:virology*; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification*; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications / Q000821:virology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology / Q000821:virology*; D008297:Male; D012367:RNA, Viral / Q000097:blood / Q000302:isolation & purification*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019562:Viral Load; D014766:Viremia / Q000150:complications / Q000821:virology*
D003450:Cryoglobulins; D012367:RNA, Viral