title: Synthesis, stereochemical assignment and biological activity of a novel series of C-4" modified aza-macrolides.
abstract: Modification of the cladinose C-4" position via manipulation of the corresponding keto derivatives afforded two stereochemically pure series of compounds. The synthesis and structure determination of these compounds is described within. The in vitro and in vivo biological activity of this novel series of C-4" modified macrolides is also described.
authors.affiliation: Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA. brian_s_bronk@groton.pfizer.com
authors.forename: Brian S
authors.initials: BS
authors.lastname: Bronk
authors.forename: Michael A
authors.initials: MA
authors.lastname: Letavic
authors.forename: Camilla D
authors.initials: CD
authors.lastname: Bertsche
authors.forename: David M
authors.initials: DM
authors.lastname: George
authors.forename: Shigeru F
authors.initials: SF
authors.lastname: Hayashi
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Kamicker
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Kolosko
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Norcia
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Rushing
authors.forename: Sheryl L
authors.initials: SL
authors.lastname: Santoro
authors.forename: Bingwei V
authors.initials: BV
authors.lastname: Yang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000187:drug effects; D006601:Hexoses / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010326:Pasteurella Infections / Q000382:microbiology; D016979:Pasteurella multocida / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D006601:Hexoses; D018942:Macrolides; C013889:cladinose