title: [Heterogenicity of Gorham-Stout syndrome: association with lymphatic and venous malformations].
abstract: BACKGROUND
  Gorham-Stout syndrome is a rare disorder of unknown etiology characterized by osteolysis and microscopic proliferation of abnormal vessels. We report two cases of this syndrome associated with lymphatic and venous malformations.
  
  
  METHODS
  The first case is a 5-year-old boy with disseminated lymphangiomatosis of poor prognosis, with significant pleural involvement and osteolytic lesions. The second case is a 5-year-old girl with a diagnosis of Klippel-Trenaunay syndrome with significant skeletal involvement of the lower extremities and secondary pathological fracture.
  
  
  CONCLUSIONS
  Gorham-Stout syndrome may occasionally be associated with various lymphatic and venous malformations. Osteolysis and bone resorption may be induced by lymphatic bone involvement.
authors.affiliation: Unidad de Cirugía Plástica Infantil. Servicio de Cirugía Pediátrica. Hospital Materno Infantil La Paz. Madrid. España. isomoza@canalejo.org
authors.forename: I
authors.initials: I
authors.lastname: Somoza Argibay
authors.forename: M
authors.initials: M
authors.lastname: Díaz González
authors.forename: L
authors.initials: L
authors.lastname: Martínez Martínez
authors.forename: Z
authors.initials: Z
authors.lastname: Ros Mar
authors.forename: J C
authors.initials: JC
authors.lastname: López-Gutiérrez
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001862:Bone Resorption / Q000175:diagnosis; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D018740:Genetic Heterogeneity; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D007715:Klippel-Trenaunay-Weber Syndrome / Q000175:diagnosis* / Q000235:genetics*; D008208:Lymphatic System / Q000002:abnormalities*; D008297:Male; D010014:Osteolysis / Q000175:diagnosis; D010015:Osteolysis, Essential / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D011994:Recombinant Proteins; D014680:Veins / Q000002:abnormalities*
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins