title: Nature's best weapons to fight cancer. Revival of human monoclonal IgM antibodies.
abstract: The unique features of monoclonal antibodies (specificity, effectiveness, purity and unlimited reproducibility) make them ideal tools for the specific treatment of all kind of diseases. The third generation of monoclonal antibodies for the treatment of human diseases will be, after murine and "humanised" murine immunoglobulins, fully human antibodies. The best source of human monoclonal antibodies are the antibody pools of cancer patients themselves with the best technique for generating them being conventional human hybridoma technology. This technique, will generate human monoclonal antibodies which will not only define important new targets on cancerous tissue, but will also provide the necessary therapeutic human antibodies in the fight against cancer.
authors.affiliation: Institute of Pathology, University of Würzburg, Josef-Schneider-Str 2, 97080 Würzburg, Germany. path027@mail.uni-wuerzburg.de
authors.forename: H Peter
authors.initials: HP
authors.lastname: Vollmers
authors.forename: Stephanie
authors.initials: S
authors.lastname: Brändlein
mesh_terms: D000911:Antibodies, Monoclonal / Q000096:biosynthesis / Q000627:therapeutic use*; D000912:Antibodies, Neoplasm / Q000096:biosynthesis / Q000627:therapeutic use*; D006801:Humans; D007113:Immunity, Innate; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000627:therapeutic use*; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D007075:Immunoglobulin M