[Alterations of G proteins in heart diseases].
Guanine nucleotide binding proteins (G proteins), known as an important signal transduction molecular, can physiologically couple extracellular signals identified by G protein-coupled receptors (GPCRs) to a series of intracellular effector to cause changes of gene transcription and protein's structure and function. Members of G protein family including Gs, Gi/o, Gq/11, and G12/13 express in the myocardium. In the heart G protein-mediated signal transduction generates diverse effects on myocardiac contractility, heart rate, heart rhythm, and myocyte growth. This review focuses on alterations of G protein in cardiac hypertrophy, heart failure, acute myocardial ischemia, and arrhythmia to help us to understand the pathogenesis and pathophysiology in heart diseases.
Zhang
Liang
L
Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100083.
Li
Li
L
Wu
Li-Ling
LL
D000818:Animals; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000145:classification / Q000502:physiology*; D006331:Heart Diseases / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D051381:Rats; D015398:Signal Transduction
D019204:GTP-Binding Proteins