title: Charcot-Marie-Tooth disease and vincristine.
abstract: This article reports on a case of sensorimotor neuropathy in a 55-year-old man that developed after vincristine therapy. Subsequent biopsy of the sural nerve and electromyographic studies revealed the presence of Charcot-Marie-Tooth disease. Only 17 patients who developed severe neuropathy with very low accumulated doses of vincristine have been described in the literature. Pain and lateral ankle instability were treated with a functional orthosis. Orthopedic treatment and the biomechanical basis of foot and ankle problems in patients with vincristine therapy-induced Charcot-Marie-Tooth disease are discussed.
authors.affiliation: Department of Podiatric Pathology, E.U. Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Angel M
authors.initials: AM
authors.lastname: Orejana-García
authors.forename: Javier
authors.initials: J
authors.lastname: Pascual-Huerta
authors.forename: Andrés
authors.initials: A
authors.lastname: Pérez-Melero
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D002607:Charcot-Marie-Tooth Disease / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D014750:Vincristine / Q000009:adverse effects*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine