Total synthesis of (+)-strictifolione.
[reaction: see text] The synthesis of (+)-strictifolione was achieved from 3-phenylproprionaldehyde by using enantioselective allyltitanations to control the stereogenic centers at C6, C4', and C6' and a cross-methathesis to control the configuration of the double bond at C1'-C2'.
BouzBouz
Samir
S
Laboratoire de Chimie Organique Associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris, Cedex 05, France.
Cossy
Janine
J
D000447:Aldehydes; D000935:Antifungal Agents / Q000138:chemical synthesis*; D003432:Cross-Linking Reagents; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011753:Pyrones / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000447:Aldehydes; D000935:Antifungal Agents; D003432:Cross-Linking Reagents; D007202:Indicators and Reagents; D011753:Pyrones; C476921:strictifolione; C421487:3-phenylpropanal