title: Expression of p53 in inverted papilloma and malignancy associated with inverted papilloma.
abstract: OBJECTIVE
  To determine the association of p53 protein in malignant cases of inverted papilloma compared with cases of benign inverted papilloma of the sinonasal tract.
  
  
  METHODS
  Case-control study of archived pathologic material.
  
  
  METHODS
  Tertiary care hospital.
  
  
  METHODS
  Archived pathologic material of cases of malignancy associated with inverted papilloma and controls of benign inverted papilloma were obtained from Mount Sinai Hospital. These were subjected to immunohistochemistry for p53. Clinical correlation was obtained by retrospective chart review.
  
  
  METHODS
  Staining of pathologic specimens for p53 and survival or recurrence.
  
  
  RESULTS
  Four of the five cases of malignancy associated with inverted papilloma demonstrated overexpression of p53. None of the benign cases of inverted papilloma demonstrated overexpression. Only two of the five patients with malignancy associated with inverted papilloma were alive at 2 years.
  
  
  CONCLUSIONS
  Overexpression of p53 may serve as a marker for malignant transformation of inverted papilloma.
authors.affiliation: Department of Otolaryngology, Mount Sinai Hospital, Toronto, ON.
authors.forename: Chetan
authors.initials: C
authors.lastname: Gujrathi
authors.forename: Irvin
authors.initials: I
authors.lastname: Pathak
authors.forename: Jeremy
authors.initials: J
authors.lastname: Freeman
authors.forename: Sylvia
authors.initials: S
authors.lastname: Asa
mesh_terms: D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D018308:Papilloma, Inverted / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53