title: Transthyretin Tyr69-to-Ile mutation (double-nucleotide substitution in codon 69) in a Japanese familial amyloidosis patient with cardiomyopathy and carpal tunnel syndrome.
abstract: A 61-year-old Japanese woman with transthyretin amyloid (ATTR) Tyr69Ile, which was caused by the mutation of TTR gene TAC to ATC at codon 69, is described. The patient had no family history and developed carpal tunnel syndrome followed by congestive heart failure due to cardiac amyloidosis. Various phenotypes of familial transthyretin amyloidosis including FAP are caused by TTR variants with single amino-acid substitutions, the latter being caused by one-point mutations in the coding region of the TTR gene. This is the first report showing a novel double-nucleotide substitution in the causative TTR gene abnormality.
authors.affiliation: Third Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. y-takei@hsp.md.shinshu-u.ac.jp
authors.forename: Yo-ichi
authors.initials: Y
authors.lastname: Takei
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hattori
authors.forename: Masahide
authors.initials: M
authors.lastname: Yazaki
authors.forename: Takahiko
authors.initials: T
authors.lastname: Tokuda
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Urasawa
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kanai
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D028226:Amyloidosis, Familial / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D009202:Cardiomyopathies / Q000503:physiopathology*; D002349:Carpal Tunnel Syndrome / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007532:Isoleucine / Q000378:metabolism; D007564:Japan; D008875:Middle Aged; D009154:Mutation; D010641:Phenotype; D011228:Prealbumin / Q000235:genetics* / Q000378:metabolism; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014443:Tyrosine / Q000378:metabolism
chemical_list: D011228:Prealbumin; D007532:Isoleucine; D014443:Tyrosine