A functionalized cobalt(III) mixed-polypyridyl complex as a newly designed DNA molecular light switch.
The ligand ODHIP (3,4-dihydroxyl-imidazo[4,5-f][1,10]phenanthroline) and its cobalt(III) complex [Co(bpy)(2)(ODHIP)](3+) were synthesized and characterized. Binding of this complex with calf thymus DNA has been investigated by spectroscopic methods and viscosity. The experimental results indicated that the complex bound to DNA by intercalation. In Tris buffer, the complex could emit relatively weak luminescence. After binding to DNA, the notable enhancement was observed. However, when the Cu(2+) was further added, the luminescence decreased gradually and disappeared after the equimolar concentrations of Cu(2+) was added, which exhibited the "off-on-off" properties of molecular light switch.
Zhang
Qian-Ling
QL
Department of Chemistry and Biology, Normal College, Shenzhen University, Shenzhen 518060, China. qlzh98@yahoo.com.cn
Liu
Jian-Hong
JH
Ren
Xiang-Zhong
XZ
Xu
Hong
H
Huang
Yi
Y
Liu
Jian-Zhong
JZ
Ji
Liang-Nian
LN
D000818:Animals; D002417:Cattle; D003035:Cobalt / Q000737:chemistry*; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D008163:Luminescent Measurements; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010618:Phenanthrolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D014783:Viscosity
D007364:Intercalating Agents; D008024:Ligands; D009942:Organometallic Compounds; D010618:Phenanthrolines; D003035:Cobalt; D003300:Copper; D004247:DNA; C427203:calf thymus DNA