Carbamazepine-related hyponatremia following cardiopulmonary bypass.
A 67-year-old man on long-term carbamazepine therapy underwent elective coronary artery bypass grafting. Following an initially uncomplicated recovery, he developed symptomatic hyponatremia. The symptoms and biochemical abnormality improved after gradual discontinuation of carbamazepine. We discuss the association between carbamazepine and hyponatremia and the causes of hyponatremia after cardiopulmonary bypass. Surgeons should consider stopping carbamazepine before operations with cardiopulmonary bypass.
Velissaris
Theodore
T
Wessex Cardiothoracic Centre, Southampton General Hospital, Southampton, United Kingdom. theovelissaris@hotmail.com
Lloyd
Clinton T
CT
Haw
Marcus P
MP
D000368:Aged; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D003327:Coronary Disease / Q000175:diagnosis / Q000601:surgery*; D017558:Elective Surgical Procedures; D005500:Follow-Up Studies; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D008297:Male; D011183:Postoperative Complications / Q000209:etiology; D011184:Postoperative Period; D018570:Risk Assessment; D014277:Trigeminal Neuralgia / Q000188:drug therapy
D002220:Carbamazepine