[Analysis of HLA-DRB1 allele polymorphism for patients with allergic rhinitis].
OBJECTIVE
To analyze the association between allergic rhinitis and HLA-DRB1 in northeast area of China.


METHODS
Using polymerase chain reaction/sequence specific primers (PCR/SSP) technique, we studied distributive speciality of HLA-DRB1 alleles in 35 patients with (AR) and 94 healthy controls.


RESULTS
The statistical results showed that the frequencies of DRB1 * 0101.2 and DRB1 * 0302 alleles were significantly higher in AR patients than in those of controls. The frequencies of DRB1 * 0101,2 and DRB1 * 0302 were 12.86% (relative risk = 15.92 Pc < 0.0004) and 5.71% (relative risk = 12.00, Pc < 0.05) respectively, the other gene frequencies bore no significant difference.


CONCLUSIONS
AR was associated with HLA-DRB1 * 0101.2 and DRB1 * 0302 alleles.
Yang
L
L
Department of Otorhinolaryngology, 202th Hospital of PLA, Shenyang 110003.
Zhang
Q
Q
Zhang
P
P
D000328:Adult; D002681:China / Q000208:ethnology; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics*; D017421:Sequence Analysis
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains