The evidence for GABAB receptor-mediated regulation of acid-base balance: involvement of Na+/H+ exchanger and Na+/HCO3- cotransporter.
A comparative analysis of the effects of gamma-aminobutyric acid (GABA) on the expressions of Na+/H+ exchanger 1 (NHE1) and Na+/HCO3- cotransporter (NBC) was investigated in order to extend our understanding of the mechanism of GABA receptor-mediated acid-base balance using a gerbil model. In vigabatrin (VGB, GABA degradation inhibitor) treated gerbils, both NHE1 and NBC immunoreactivities in the hippocampus were significantly elevated, as compared with the controls. Analogous to VGB treatment, baclofen (GABAB receptor agonist) treatment also evoked elevations of both NHE1 and NBC expressions in the hippocampus, whilst their expressions were unaffected by muscimol (GABAA receptor agonist) treatment. Therefore, our findings suggest that GABAB receptor-mediated regulation of NHE1 and NBC expressions may participate in acid-base balance in the gerbil hippocampus.
Kang
Tae-Cheon
TC
Department of Anatomy, College of Medicine, Hallym University, Chunchon, Kangwon-Do, 200-702, South Korea. tckang@hallym.ac.kr
An
Sung-Jin
SJ
Park
Seung-Kook
SK
Hwang
In-Koo
IK
Bae
Jae Chun
JC
Won
Moo Ho
MH
D000136:Acid-Base Equilibrium / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018755:GABA Agonists / Q000494:pharmacology; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism*; D009118:Muscimol / Q000494:pharmacology; D018080:Receptors, GABA-B / Q000378:metabolism*; D027982:Sodium-Bicarbonate Symporters / Q000378:metabolism*; D017923:Sodium-Hydrogen Exchangers / Q000378:metabolism*; D020888:Vigabatrin / Q000494:pharmacology
D004791:Enzyme Inhibitors; D018755:GABA Agonists; D018080:Receptors, GABA-B; D027982:Sodium-Bicarbonate Symporters; D017923:Sodium-Hydrogen Exchangers; C069139:growth factor-activatable Na-H exchanger NHE-1; D009118:Muscimol; D020888:Vigabatrin; D001418:Baclofen