The association of the expression of vascular endothelial growth factor with the cystic component and haemorrhage in pituitary adenoma.
Vascular endothelial growth factor (VEGF) is known to be a mediator of angiogenesis and vascular permeability. A cystic component and haemorrhage are often found in pituitary adenomas. We assessed the VEGF expression based on immunohistochemical examinations in 48 pituitary adenomas. All the adenomas showed some VEGF immunoreactivity mainly in the cytoplasm of tumour cells. Of the 48 adenoma-cases, 16 cases had a strong VEGF immunoreactivity, 26 cases had a moderate one, and 6 cases had a weak one. On the MR images, a cystic component was found in 16 cases (33.3%), and a haemorrhage was found in 18 cases (37.5%). The VEGF immunoreactivity had a significant relationship with the cystic component but not the haemorrhage, size, recurrence, or HE classification. These findings suggest that VEGF plays any potential role in the pathogenesis of cystic formation in pituitary adenomas.
Fukui
Shinji
S
Department of Neurosurgery, National Defense Medical College, 3-2 Namiki, Saitama 359-8513, Tokorozawa, Japan. grd1309@gr.ndmc.ac.jp
Otani
Naoki
N
Nawashiro
Hiroshi
H
Yano
Akiko
A
Nomura
Namiko
N
Tokumaru
Aya M
AM
Miyazawa
Takahito
T
Ohnuki
Akira
A
Tsuzuki
Nobusuke
N
Katoh
Hiroshi
H
Ishihara
Shoichiro
S
Shima
Katsuji
K
Ooigawa
Hidetoshi
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D003560:Cysts / Q000000981:diagnostic imaging / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D011859:Radiography; D012008:Recurrence; D012189:Retrospective Studies; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D014965:X-Rays; D055815:Young Adult
D042461:Vascular Endothelial Growth Factor A