title: Extracorporeal gas exchange with the DeltaStream rotary blood pump in experimental lung injury.
abstract: In most severe cases of the acute respiratory distress syndrome, veno-venous extracorporeal membrane oxygenation (ECMO) can be used to facilitate gas exchange. However, the clinical use is limited due to the size and the concomitant risk of severe adverse events of conventionally-used centrifugal blood pumps with high extracorporeal blood volumes. The DeltaStream blood pump is a small-sized rotary blood pump that may reduce extracorporeal blood volume, foreign surfaces, contact activation of the coagulation system, and blood trauma. The aim of the present study was to test the safety and efficacy of the DeltaStream pump for ECMO in animals with normal lung function and experimental acute lung injury (ALI). Therefore, veno-venous ECMO was performed for 6 hours in mechanically ventilated pigs with normal lung function (n=6) and with ALI induced by repeated lung lavage (n=6) with a blood flow of 30% of the cardiac output. Gas flow with a FiO2 of 1.0 was set to equal blood flow. With a mean activated clotting time of 121 +/- 22 s, no circulatory impairment or thrombus formation was revealed during ECMO. Furthermore, free plasma Hb did not increase. In controls, hemodynamics and gas exchange remained unchanged. In animals with ALI, hemodynamics remained stable and gas transfer across the extracorporeal oxygenators was optimal, but only in 2 animals was a marked increase in PaO2 observed. CO2 removal was efficacious in all animals. We concluded that the DeltaStream blood pump may be used for veno-venous ECMO without major blood damage or hemodynamic impairment.
authors.affiliation: Department of Anesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany.
authors.forename: Rolf
authors.initials: R
authors.lastname: Dembinski
authors.forename: Rüdger
authors.initials: R
authors.lastname: Kopp
authors.forename: Dietrich
authors.initials: D
authors.lastname: Henzler
authors.forename: Nadine
authors.initials: N
authors.lastname: Hochhausen
authors.forename: Nicole
authors.initials: N
authors.lastname: Oslender
authors.forename: Martin
authors.initials: M
authors.lastname: Max
authors.forename: Rolf
authors.initials: R
authors.lastname: Rossaint
authors.forename: Ralf
authors.initials: R
authors.lastname: Kuhlen
mesh_terms: D000818:Animals; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D008168:Lung / Q000502:physiology* / Q000503:physiopathology*; D008171:Lung Diseases / Q000628:therapy*; D017063:Outcome Assessment, Health Care; D011659:Pulmonary Gas Exchange / Q000502:physiology; D013552:Swine