title: Stability and antibacterial activity of cefepime during continuous infusion.
abstract: The stability of cefepime during simulated continuous infusion was determined with a motorized portable infusion pump worn over a period of 24 to 36 h. Susceptibility testing on cefepime solutions over time indicates that the degradation products do not exhibit antibacterial activity. Cefepime stability at 24 h following continuous infusion was 94.3% +/- 1.0%, which supports the use of continuous infusion.
authors.affiliation: University of Oslo, Oslo, Norway.
authors.forename: Pål F
authors.initials: PF
authors.lastname: Sprauten
authors.forename: Paul M
authors.initials: PM
authors.lastname: Beringer
authors.forename: Stan G
authors.initials: SG
authors.lastname: Louie
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Synold
authors.forename: Mark A
authors.initials: MA
authors.lastname: Gill
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D000077723:Cefepime; D002511:Cephalosporins / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D004355:Drug Stability; D004356:Drug Storage; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000077723:Cefepime