Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals.
Sera from infected injection drug users (IDU) have shown to have antibodies against synthetic human immunodeficiency virus-1 (HIV-1) envelope peptides more frequently. In this study, reactivity of 48 IDU plasma were compared to 60 plasmas obtained from sexually infected individuals (S). The overall reactivity of plasma from IDU compared to S was higher, and the reactivity titers were much higher for IDU plasma than S. IDU plasma also showed a broader antibody response. The higher reactivity titers were observed mainly for the gp41 immunodominant epitope and V3 peptides corresponding to the consensus sequences of HIV-1 subtypes/variants prevalent in Brazil (B, F, C) indicating the specificity in the higher immune response of IDU.
Bongertz
Vera
V
Laborat rio de Aids e Imunologia Molecular, Departamento de Imunologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brasil. bongertz@ioc.fiocruz.br
Ouverney
Elaine Priscilla
EP
Teixeira
Sylvia L M
SL
Silva-de-Jesus
Carlos
C
Hacker
Mariana A
MA
Morgado
Mariza G
MG
Bastos
Francisco I
FI
D003429:Cross Reactions; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015483:HIV Antibodies / Q000276:immunology*; D015699:HIV Envelope Protein gp120 / Q000276:immunology*; D015700:HIV Envelope Protein gp41 / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000276:immunology*; D011379:Prognosis; D012725:Sexual Behavior; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000276:immunology
D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120; D015700:HIV Envelope Protein gp41; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments