Direction control in DNA binding of chiral D-lysine-based peptide nucleic acid (PNA) probed by electrospray mass spectrometry.
The DNA binding abilities of peptide nucleic acids (PNAs), both achiral and bearing three adjacent D-lysine-based monomers in the middle of the strand ("chiral box" PNA), were studied by means of electrospray mass spectrometry (ESI-MS). In contrast with achiral PNA, "Chiral box" PNA was confirmed to exert high direction control (antiparallel vs. parallel DNA target) in DNA binding.
Sforza
Stefano
S
Dipartimento di Chimica Organica ed Industriale, Università di Parma, Parco Area delle Scienze 17/a, I-43100 Parma, Italy. stefano.sforza@unipr.it
Tedeschi
Tullia
T
Corradini
Roberto
R
Dossena
Arnaldo
A
Marchelli
Rosangela
R
D004247:DNA / Q000737:chemistry*; D008239:Lysine / Q000737:chemistry*; D015394:Molecular Structure; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
D020135:Peptide Nucleic Acids; D004247:DNA; D008239:Lysine