DNA damage in brain cells of mice treated with an oxidized form of apomorphine.
We investigated whether systemic injection of apomorphine and its oxidation derivative 8-oxo-apomorphine-semiquinone (8-OASQ) could induce DNA damage in mice brain, using the single-cell gel assay. 8-OASQ induced DNA damage in the brains at 1 and 3 h, but not at 24 h after treatment whereas apomorphine induced a slight increase in brain DNA damage frequency at 3 h after treatment, suggesting that both drugs display genotoxic activity in brain tissue.
Picada
Jaqueline Nascimento
JN
GENOTOX-Genotoxicity Laboratory, Center for Biotechnology, and Department of Biophysics, Institute of Biosciences, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves, 9500, 91501-970, RS, Porto Alegre, Brazil.
Flores
Debora G
DG
Zettler
Cláudio G
CG
Marroni
Norma Possa
NP
Roesler
Rafael
R
Henriques
João Antonio Pêgas
JA
D000818:Animals; D001058:Apomorphine / Q000031:analogs & derivatives / Q000633:toxicity*; D001921:Brain / Q000187:drug effects; D020552:Comet Assay; D004249:DNA Damage; D018491:Dopamine Agonists / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D011809:Quinones / Q000633:toxicity*
C470323:8-oxo-apomorphine-semiquinone; D018491:Dopamine Agonists; D011809:Quinones; D001058:Apomorphine