title: Offspring sex ratio is not associated with parental GSTT1 and GSTM1 null genotypes.
abstract: The present study evaluated the association between offspring sex ratio and parental inherited variations of xenobiotic metabolism by glutathione S-transferase (GST) T1 and GSTM1. Polymorphisms of GSTT1 and GSTM1 were investigated in 235 Iranian Muslims (153 males, 82 females) using polymerase chain reaction-based method. Statistical analysis of 890 offspring in the study families revealed that there was no association between GSTM1 null genotype of either the fathers (OR=1.28; 95% CI=0.88-1.85; P=0.17) or mothers (OR=0.77; 95% CI=0.49-1.19; P=0.22) and offspring sex ratio. There was no association between paternal GSTT1 null genotype and sex ratio in offspring (OR=1.04; 95% CI=0.71-1.54; P=0.84), whereas there was a weak association between maternal GSTT1 null genotype and offspring sex ratio (OR=1.54; 95% CI=1.0-2.38; P=0.05). Combination of parental GSTT1 and GSTM1 genotypes showed no association with offspring sex ratio.
authors.affiliation: Department of Biology, Shiraz University, Shiraz 71454, Iran. saadat@susc.ac.ir
authors.forename: Mostafa
authors.initials: M
authors.lastname: Saadat
authors.forename: Iraj
authors.initials: I
authors.lastname: Saadat
mesh_terms: D005260:Female; D005828:Genetics, Population; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007492:Iran; D008297:Male; D010290:Parents; D011110:Polymorphism, Genetic; D019655:Quantitative Trait, Heritable; D012744:Sex Ratio
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1