title: [Study on the preparation of venenum bufonis beta-cyclodextrin inclusion complexes].
abstract: OBJECTIVE
  To study the preparation of Venenum Bufonis beta-cyclodextrin inclusion complexes.
  
  
  METHODS
  An optimal condition was established by the uniform design. Under the optimal conditions the Venenum Bufonis beta-cyclodextrin inclusion complexes were prepared with 5 different methods.
  
  
  RESULTS
  The ball grinding method was superior to other four methods. The bufadienolide inclusion rate of Venenum Bufonis beta-cyclodextrin prepared with ball grinding method was 85.42%.
  
  
  CONCLUSIONS
  Ball grinding method is the best method for the preparation of Venenum Bufonis beta-cyclodextrin inclusion complexes.
authors.affiliation: Shenyang Military General Hospital, Shenyang 110016, Liaoning, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
authors.forename: Hong-tao
authors.initials: HT
authors.lastname: Song
authors.forename: Ming-hong
authors.initials: MH
authors.lastname: Zhao
authors.forename: Ru-hua
authors.initials: RH
authors.lastname: Zhang
authors.forename: Xian
authors.initials: X
authors.lastname: Li
mesh_terms: D000664:Amphibian Venoms / Q000008:administration & dosage* / Q000737:chemistry; D000818:Animals; D002018:Bufanolides; D002023:Bufo bufo; D002770:Cholenes / Q000032:analysis; D003505:Cyclodextrins; D004337:Drug Carriers; D004355:Drug Stability; D008419:Materia Medica / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D047392:beta-Cyclodextrins
chemical_list: D000664:Amphibian Venoms; D002018:Bufanolides; D002770:Cholenes; D003505:Cyclodextrins; D004337:Drug Carriers; D008419:Materia Medica; D047392:beta-Cyclodextrins; C087925:bufadienolide; C031215:betadex