title: The function of the spleen in adults after ligation of the splenic artery of the traumatized spleen in childhood.
abstract: BACKGROUND
  Ligation of the splenic artery (LSA) has been successfully used as a spleen-saving procedure in rare cases of splenic trauma in children in which management with splenorrhaphy or partial splenectomy alone was not possible. There are no data regarding the long-term effects of the procedure on the functional status of the spleen. The purpose of this study is to present and discuss our clinical and laboratory findings in adults who underwent LSA in childhood.
  
  
  METHODS
  Our first 2 patients in whom LSA was done at ages 4 and 2 years in 1977 underwent the following examinations in the year 2000: 1, imaging of the spleen; 2, immunologic studies; and 3, peripheral blood tests. Their ages at reexamination were 27 and 25 years, respectively.
  
  
  RESULTS
  Results were as follows: triplex ultrasound revealed normal size and echomorphology; Doppler techniques revealed normal vasculature; 99mTc-Tin colloid scanning revealed normal uptake. Immunoglobulins (IgG1 to IgG4, IgA, IgM, IgE), complement fraction (C3, C4), antibodies response to vaccinations, and peripheral blood tests all had normal results. No Howell-Jolly bodies were found.
  
  
  CONCLUSIONS
  Laboratory investigations in adults with LSA during childhood disclosed undisturbed function of the spleen. LSA can be used as an adjunct to splenorrhaphy in children with rare splenic injuries involving major hilar vessels.
authors.affiliation: Department of Pediatric Surgery, Aghia Sophia Children's Hospital, Athens, Greece.
authors.forename: Dimitrios C
authors.initials: DC
authors.lastname: Keramidas
authors.forename: Michael
authors.initials: M
authors.lastname: Soutis
mesh_terms: D000328:Adult; D000906:Antibodies / Q000032:analysis; D002675:Child, Preschool; D003165:Complement System Proteins / Q000378:metabolism; D005260:Female; D006403:Hematologic Tests; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D008026:Ligation; D008297:Male; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging / Q000293:injuries* / Q000503:physiopathology*; D013157:Splenic Artery / Q000000981:diagnostic imaging / Q000601:surgery*; D017556:Technetium Compounds; D014001:Tin; D018608:Ultrasonography, Doppler; D014611:Vaccination; D014947:Wounds and Injuries / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery*
chemical_list: D000906:Antibodies; D007136:Immunoglobulins; D017556:Technetium Compounds; D014001:Tin; D003165:Complement System Proteins