The antiplatelet aggregation effects of aspirin suppositories.
To confirm that aspirin suppositories are an effective treatment for acute ischemic stroke, we examined the suppressive effects of 200-mg aspirin suppositories on platelet aggregation. Aspirin suppositories suppressed platelet aggregation induced by ADP or collagen, and the suppression continued for 24 h. There was no significant difference in suppression of platelet aggregation between aspirin administered by suppository and orally given aspirin. These results suggest that aspirin suppositories are a useful treatment for acute ischemic stroke.
Nakayasu
Hiroyuki
H
Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan.
Maeda
Masanobu
M
Soda
Takao
T
Iijima
Kenji
K
Ishimoto
Manabu
M
Ieiri
Ichiro
I
Tabuchi
Fumie
F
Otsubo
Kenji
K
Nakashima
Kenji
K
D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000328:Adult; D001241:Aspirin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003094:Collagen / Q000037:antagonists & inhibitors / Q000494:pharmacology; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012727:Sex Characteristics; D013488:Suppositories
D010975:Platelet Aggregation Inhibitors; D013488:Suppositories; D000244:Adenosine Diphosphate; D003094:Collagen; D001241:Aspirin