title: [Contribution of linezolid to the treatment of complicated infections of the skin and soft tissues].
abstract: THREE GROUPS OF INCREASING SEVERITY: According to the 2000 consensus conference, bacterial infections of the skin and soft tissues can be classified in three categories of increasing severity: bacterial dermo-hypodermal infections, bacterial dermo-hypodermal necrotizing infections, necrotizing fasciitis. The last two categories are medicosurgical emergency conditions requiring repeated surgical debridement and probabilistic antibiotic therapy. LINEZOLID: The clinical efficacy of linezolid in bacterial infections of the skin and soft tissues is comparable to that of oxacillin/dicloxacillin. Several arguments (frequent implication of Streptococcus pyogenes and Staphylococcus aureus, well-adapted spectrum, changing resistance pattern of Gram-positive cocci, efficacy against associated bacteriemia, favorable kinetics and diffusion data in cutaneous tissues) argue in favor of the use of linezolid in infections of the skin and soft tissues
authors.affiliation: Service de réanimation CHU Jean Verdier, Bondy (93).
authors.forename: Rémy
authors.initials: R
authors.lastname: Gauzit
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D018849:Controlled Clinical Trials as Topic; D005602:France / Q000453:epidemiology; D006801:Humans; D000069349:Linezolid; D010068:Oxacillin / Q000627:therapeutic use; D023303:Oxazolidinones / Q000627:therapeutic use*; D010406:Penicillins / Q000627:therapeutic use; D017192:Skin Diseases, Bacterial / Q000188:drug therapy* / Q000453:epidemiology; D018461:Soft Tissue Infections / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D010406:Penicillins; D000069349:Linezolid; D010068:Oxacillin