Evaluation of systemic and secretory IgA concentrations and immunohistochemical stains for IgA-containing B cells in mucosal tissues of an Irish setter with selective IgA deficiency.
Immunoglobulin A is the predominant secretory antibody at mucosal surfaces. In the dog, immunoglobulin A deficiency (IgAD) is characterized by low to absent serum IgA and normal to elevated serum immunoglobulin G (IgG) and immunoglobulin M (IgM) concentrations. However, studies comparing serum and secretory IgA in dogs have often documented a poor correlation, suggesting that serum concentrations should not be used to estimate mucosal secretion of this antibody. This report demonstrates the concurrent use of serum IgA, IgG, and IgM; secretory IgA (from bronchoalveolar lavage fluid); and immunohistochemical stains on bronchial and duodenal mucosa for IgA-containing B cells in a young Irish setter with recurrent respiratory and gastrointestinal signs.
Norris
Carol R
CR
Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616, USA.
Gershwin
Laurel J
LJ
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001980:Bronchi; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D004285:Dogs; D004386:Duodenum; D005260:Female; D017098:IgA Deficiency / Q000175:diagnosis / Q000662:veterinary*; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D007150:Immunohistochemistry / Q000662:veterinary; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism; D020545:Respiratory Mucosa / Q000276:immunology / Q000378:metabolism
D007071:Immunoglobulin A, Secretory