HIV lipodystrophy etiology and pathogenesis. Body composition and metabolic alterations: etiology and pathogenesis.
The results of epidemiologic investigations have clearly indicated that the development of lipodystrophy is multifactorial. Factors related to HIV infection, hormonal influences, mitochondrial dysfunction, cytokine activation related to immune reconstitution, and individual genetic predisposition all have been hypothesized as etiologic. Recent studies suggest that immune dysregulation rather than HIV infection per se may be the predominant factor in the development of lipodystrophy.
Kotler
Donald P
DP
Department of Medicine, Division of Gastroenterology, Columbia University College of Physicians & Surgeons, New York, USA.
D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001823:Body Composition; D039682:HIV-Associated Lipodystrophy Syndrome / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D006801:Humans