ACTH and adrenocortical gap junctions.
Since the initial identification of gap junctions in the adrenal gland, it has been proposed that a system involving direct cell-cell communication might be involved in adrenal cortical functions. Gap junction channels do, in fact, provide pathways for direct intercellular exchange of small molecules (<1,000 Da), many of which have the potential to influence a wide range of cellular activities. Gap junctions are composed of proteins called connexin which, in the adrenal cortex, have proven to be remarkably consistent in both type and zonal distribution with connexin 43 (Cx43) as the predominant component in mammalian adrenal glands thus far evaluated. Only the inner two zones of the cortex (zonae fasciculata and reticularis) exhibit significant amounts of Cx43 and functional coupling. Adrenocorticotropin (ACTH) has been shown to increase Cx43 protein in vivo and in vitro, and a strong correlation has been noted between the presence of gap junctions and certain adrenal cortical functions, especially steroidogenic capacity and cell proliferation. This review summarizes evidence of the Cx43 expression in adrenal cortical cells and the likely role of Cx43 in steroidogenesis and cell proliferation. It is concluded that control of gap junction expression in the adrenal gland is hormonally dependent and is functionally linked to adrenal gland zonation.
Murray
Sandra A
SA
Department of Cell Biology and Physiology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA. smurray@pitt.edu
Davis
Kevin
K
Gay
Vernon
V
D000302:Adrenal Cortex / Q000502:physiology / Q000648:ultrastructure*; D000324:Adrenocorticotropic Hormone / Q000502:physiology*; D000818:Animals; D017629:Gap Junctions / Q000502:physiology / Q000648:ultrastructure*; D006801:Humans
D000324:Adrenocorticotropic Hormone