A convenient one-pot synthesis of 1,8-naphthyridones.
In this paper, we disclose an efficient one-pot procedure for the preparation of substituted 1,8-naphthyridin-4-one analogues. Previous efforts to effect this type of transformation were complicated by the formation of benzene tricarboxylate. Via the use of excess base, the impurity formation was completely inhibited. This allowed for the clean preparation of the desired intermediate and subsequent formation of naphthyridone analogues in a single flask, which could then be crystallized directly from the reaction mixture in good yield and high purity.
Springfield
Shawn A
SA
Department of Process Research, Merck & Co. Inc., P.O. Box 2000, Rahway, New Jersey 07065-0900, USA. shawn_springfield@merck.com
Marcantonio
Karen
K
Ceglia
Scott
S
Albaneze-Walker
Jennifer
J
Dormer
Peter G
PG
Nelson
Todd D
TD
Murry
Jerry A
JA