[Experimental studies of hypoglycemic action on total flavone of Ampelopsis grossedentata from Guangxi].
OBJECTIVE
To study hypoglycemic action of total flavone (GXTF) of Ampelopsis grossedentata from Guangxi by observing the effects of GXTF on blood glucose levels in many strain animal models.


METHODS
The blood glucose levels in many strain animal models were determined after oral administration, with the models of diabetes induced by alloxan, of hyperglycemic mice induced by epinephrine and glucose, and normal mice.


RESULTS
GXTF had better therapeutical action on diabetes mice induced by alloxan, and could significantly lowered the blood glucose levels of hyperglycemic mice induced by epinephrine and glucose, but had no significant effects on blood glucose levels of normal mice. Acute toxicity test showed that the maximum oral dosage is 26.0 g.kg-1.


CONCLUSIONS
GXTF has better hypoglycemic effect on many strain animal models and toxicity is vary small.
Zhong
Zheng-xian
ZX
Guangxi Institute of Traditional Medical and Pharma-ceutical Sciences, Nanning 530022, Guangxi, China. zhongzhengxian@163.net
Qin
Jie-pin
JP
Zhou
Gui-fen
GF
Chen
Xue-fen
XF
D032421:Ampelopsis / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002681:China; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004837:Epinephrine / Q000037:antagonists & inhibitors; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D005947:Glucose / Q000037:antagonists & inhibitors; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D007004:Hypoglycemic Agents; D005947:Glucose; D004837:Epinephrine