Decomposition of an aqueous solution of [11C]Ro 15-4513: implication of hydrated electrons in the radiolysis of [11C]Ro 15-4513.
An aqueous solution of [(11)C]Ro 15-4513 underwent decomposition to give a few radioactive degradation products. The major degradation product corresponded to that of authentic Ro 15-4513 with (60)Co radiolysis, which showed a molecular weight of 301 (M+H). The structure of this degradation product was estimated to have an amine group instead of an azido group on Ro 15-4513. Radiolysis of Ro 15-4513 was not suppressed by the addition of selective hydroxyl radical scavenger (MeOH, HCOO(-)), in contrast, it was suppressed effectively in the presence of a selective hydrated electron scavenger (NaNO(3)), suggesting that hydrated electrons would play an important role in the radiolysis of [(11)C]Ro 15-4513.
Fukumura
Toshimitsu
T
Radiopharmaceutical Chemistry Section, Department of Medical Imaging, National Institute of Radiological Sciences, 4-9-1, Anagawa Inage-ku Chiba, 263-8555, Japan. t_fukumu@nirs.go.jp
Akaike
Shihori
S
Yoshida
Yuichirou
Y
Suzuki
Kazutoshi
K
D001386:Azides / Q000737:chemistry*; D001569:Benzodiazepines / Q000737:chemistry*; D010782:Photolysis; D011675:Pulse Radiolysis; D012996:Solutions
D001386:Azides; D012996:Solutions; D001569:Benzodiazepines; C042957:Ro 15-4513