Molecular targets of hyperphosphataemia in chronic renal failure.
Dietary phosphate restriction can prevent or retard the progress of chronic renal failure (CRF) and secondary hyperparathyroidism. The klotho gene is involved in the development of a syndrome resembling human ageing, and klotho mutant mice show abnormal calcium/vitamin D metabolism, developing hyperphosphataemia and vascular calcification. Phosphate retention rescues the phenotype of klotho mice. The level of expression of klotho RNA was greatly reduced in the kidneys of all CRF patients. Dietary P(i) restriction induced klotho expression, which enhances the beneficial effect of P(i) restriction in patients with CRF and/or on haemodialysis.
Miyamoto
Ken-ichi
K
Department of Nutrition, School of Medicine, Tokushima University, Japan.
Ito
Mikiko
M
Segawa
Hiriko
H
Kuwahata
Masashi
M
D000818:Animals; D015870:Gene Expression; D005966:Glucuronidase; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D000090265:Klotho Proteins; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics; D010641:Phenotype; D010760:Phosphorus Metabolism Disorders / Q000209:etiology* / Q000235:genetics*; D012313:RNA / Q000378:metabolism
D008565:Membrane Proteins; D012313:RNA; D005966:Glucuronidase; D000090265:Klotho Proteins