title: Poor potential coverage for 7-valent pneumococcal conjugate vaccine, Malawi.
abstract: Streptococcus pneumoniae infections can be prevented by using new conjugate vaccines, but these vaccines have limited serogroup coverage. We report the first serogrouping data from carried and invasive isolates obtained from children and adults in Malawi. The 7-valent vaccine would cover 41% of invasive isolates from children and 25% from adults. A 9-valent vaccine, including types 1 and 5, would cover 66% of invasive isolates from children and 55% from adults.
authors.affiliation: Wellcome Trust Research Laboratories, University of Malawi, Liverpool, UK. sgordon@mlw.medcol.mw
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Gordon
authors.forename: Stonard
authors.initials: S
authors.lastname: Kanyanda
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Walsh
authors.forename: Kirsty
authors.initials: K
authors.lastname: Goddard
authors.forename: Mas
authors.initials: M
authors.lastname: Chaponda
authors.forename: Victoria
authors.initials: V
authors.lastname: Atkinson
authors.forename: Wakisa
authors.initials: W
authors.lastname: Mulwafu
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Molyneux
authors.forename: Ed E
authors.initials: EE
authors.lastname: Zijlstra
authors.forename: Malcolm E
authors.initials: ME
authors.lastname: Molyneux
authors.forename: Steve M
authors.initials: SM
authors.lastname: Graham
mesh_terms: D000328:Adult; D002353:Carrier State; D002648:Child; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D008295:Malawi / Q000453:epidemiology; D022401:Meningococcal Vaccines / Q000276:immunology / Q000627:therapeutic use; D009305:Nasopharynx / Q000382:microbiology; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000276:immunology / Q000627:therapeutic use; D011159:Population Surveillance; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines