title: Low-grade malignant eccrine spiradenoma with systemic metastases.
abstract: Malignant eccrine spiradenoma (MES) is a very rare tumor. Tumors can be low grade or high grade. There are nine cases in the literature with systemic metastases. Of these, only one was low grade; the others had obvious features of high-grade malignancy such as pleomorphism, increased mitoses, and abnormal mitoses. Low grade MESs are more difficult to diagnose and are said to have a better prognosis. We report an additional case of low-grade MES with systemic metastases. It had a monotonous appearance with few mitotic figures and minimal pleomorphism. Vascular invasion was seen in both cases of low-grade MES and may be an important prognostic feature.
authors.affiliation: Department of Histopathology, Royal Victoria Infirmary, Newcastle-upon-Tyne, England, UK. niamh.leonard@rlbuh-tr.nwest.nhs.uk
authors.forename: Niamh
authors.initials: N
authors.lastname: Leonard
authors.forename: David
authors.initials: D
authors.lastname: Smith
authors.forename: Paul
authors.initials: P
authors.lastname: McNamara
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000601:surgery; D006607:Adenoma, Sweat Gland / Q000473:pathology / Q000601:surgery; D001706:Biopsy; D001859:Bone Neoplasms / Q000556:secondary*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013544:Sweat Gland Neoplasms / Q000473:pathology* / Q000601:surgery