title: Analysis of albendazole metabolites by electrospray LC-MS/MS as a probe to elucidate electro-oxidation mechanism of albendazole.
abstract: The electrochemical oxidation of albendazole was accomplished by controlled potential electrolysis technique. The oxidation was carried out in different pH solutions and yields the same products obtained by in vivo and in vitro metabolism, i.e. albendazole sulfoxide and albendazole sulfone. The identification of albendazole oxidation products was carried out by LC-MS/MS.
authors.affiliation: Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, USP, Av. dos Bandeirantes, 3900, 14040-901, Ribeirão Preto, São Paulo, Brazil.
authors.forename: Renata Galvão
authors.initials: RG
authors.lastname: de Lima
authors.forename: Pierina Sueli
authors.initials: PS
authors.lastname: Bonato
authors.forename: Roberto Santana
authors.initials: RS
authors.lastname: da Silva
mesh_terms: D015766:Albendazole / Q000032:analysis* / Q000378:metabolism*; D004563:Electrochemistry; D010084:Oxidation-Reduction; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
chemical_list: D015766:Albendazole