ProPred1: prediction of promiscuous MHC Class-I binding sites.
CONCLUSIONS
ProPred1 is an on-line web tool for the prediction of peptide binding to MHC class-I alleles. This is a matrix-based method that allows the prediction of MHC binding sites in an antigenic sequence for 47 MHC class-I alleles. The server represents MHC binding regions within an antigenic sequence in user-friendly formats. These formats assist user in the identification of promiscuous MHC binders in an antigen sequence that can bind to large number of alleles. ProPred1 also allows the prediction of the standard proteasome and immunoproteasome cleavage sites in an antigenic sequence. This server allows identification of MHC binders, who have the cleavage site at the C terminus. The simultaneous prediction of MHC binders and proteasome cleavage sites in an antigenic sequence leads to the identification of potential T-cell epitopes.


BACKGROUND
Server is available at http://www.imtech.res.in/raghava/propred1/. Mirror site of this server is available at http://bioinformatics.uams.edu/mirror/propred1/ SUPPLEMENTARY INFORMATION: Matrices and document on server are available at http://www.imtech.res.in/raghava/propred1/page2.html
Singh
Harpreet
H
Institute of Microbial technology, Chandigarh 160036, India.
Raghava
G P S
GP
D017951:Antigen Presentation; D001665:Binding Sites; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000235:genetics; D030562:Databases, Protein; D015395:Histocompatibility Antigens Class I / Q000737:chemistry* / Q000235:genetics; D020407:Internet; D046911:Macromolecular Substances; D008285:Major Histocompatibility Complex / Q000235:genetics; D009097:Multienzyme Complexes / Q000737:chemistry / Q000235:genetics; D009842:Oligopeptides / Q000737:chemistry; D010455:Peptides / Q000737:chemistry* / Q000235:genetics; D046988:Proteasome Endopeptidase Complex; D011485:Protein Binding; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software; D014584:User-Computer Interface
D015395:Histocompatibility Antigens Class I; C408902:MHC binding peptide; D046911:Macromolecular Substances; D009097:Multienzyme Complexes; D009842:Oligopeptides; D010455:Peptides; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex