[Effects of the zhikuofang on the inflammation and cytostatics of the airway model of bronchiectasis].
OBJECTIVE
To explore the effects of Zhikuofang, a TCM prescription, and Ofloxacin on the inflammation and cytostatics of the airway model of bronchiectasis.


METHODS
The airway model of bronchiectasis (AMB) was set up and infused with Ps. Aeruginosa. A comparison between the effects of Zhikuofang and Of loxacin on the AMB was made.


RESULTS
Zhikuofang is better than Ofloxacin in following aspects: lowering the density of inflammation cells in blood, decreasing the volume of tracheal secretion and inhibiting the cytostatics (IL-8 and TNF-alpha) of the trachea tissue, but Ofloxacin is more effective in diminishing the amount of bacteria in trachea flushing liquor. There was no marked difference between them in their histopathy effects on the trachea.


CONCLUSIONS
Zhikuofang probably plays antiphlogistic and bacteriostatic effects by inhibiting the IL-8 and TNF-alpha, resisting secretion, decreasing the inflammation cells and resisting inflammation of trachea.
Wan
Yi-gang
YG
Affiliated Drum Tower Hospital of Medical College of Nanjing University, Jiangsu, Nanjing 210008, China. wyg68918@sina.net
Cao
Shi-hong
SH
Bi
Jian-jun
JJ
Zhu
Yun-hua
YH
Zhou
Yue
Y
Zhou
Ming
M
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D001987:Bronchiectasis / Q000378:metabolism* / Q000382:microbiology; D001991:Bronchitis / Q000378:metabolism* / Q000382:microbiology; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D016209:Interleukin-8 / Q000378:metabolism; D008297:Male; D015242:Ofloxacin / Q000494:pharmacology; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry*; D011552:Pseudomonas Infections; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000890:Anti-Infective Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D015242:Ofloxacin