Marine natural products as lead anti-HIV agents.
Current anti-HIV drugs have extreme side effects and resistance to these drugs develops rapidly. The marine environment holds an unprecedented number of unusual chemical structural classes with activity against HIV. We review the literature on anti-HIV activity of marine natural products and discuss the efficacy of different structural classes.
Gochfeld
D J
DJ
Department of Pharmacognosy and the National Center for Natural Products Research, School of Pharmacy, P.O. Box 1848, The University of Mississippi, University, MS 38677, USA.
El Sayed
K A
KA
Yousaf
M
M
Hu
J F
JF
Bartyzel
P
P
Dunbar
D C
DC
Wilkins
S P
SP
Zjawiony
J K
JK
Schinazi
R F
RF
Schlueter Wirtz
S
S
Tharnish
P M
PM
Hamann
M T
MT
D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008386:Marine Biology; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D001688:Biological Products