title: Diazepam as a treatment for metronidazole toxicosis in dogs: a retrospective study of 21 cases.
abstract: The currently recommended treatment for metronidazole toxicosis is drug discontinuation and supportive therapy. Reported recovery times are 1-2 weeks. The records of 21 dogs with metronidazole toxicosis were retrospectively analyzed to determine whether diazepam improved recovery. The dosage and duration of metronidazole therapy and the response and recovery times of 13 dogs treated with diazepam were compared to those of 8 dogs receiving only supportive care. Response time was defined as the time to resolution of the debilitating clinical signs. Recovery time was the time to resolution of all residual clinical signs. The average dosage and duration of metronidazole administration for the diazepam-treated and untreated groups were 60.3 mg/kg/d for 44.9 days and 65.1 mg/kg/d for 37.25 days. The protocol for diazepam administration consisted of an initial i.v. bolus and then diazepam PO q8h for 3 days. The average dosage of both the i.v. and PO diazepam was 0.43 mg/kg. The average response time for the diazepam-treated dogs was 13.4 hours compared to 4.25 days for the untreated group. Recovery time also was markedly shorter for the diazepam-treated dogs (38.8 hours) compared to the untreated group (11 days). Results of this study showed that dogs with metronidazole toxicosis recover faster when treated with diazepam. Although the mechanism of metronidazole toxicosis or how diazepam exerts its favorable effect is not known, it is likely related to modulation of the gamma-aminobutyric acid (GABA) receptor within the cerebellar and vestibular systems.
authors.affiliation: Veterinary Neurological Center, Las Vegas, NV 89108, USA. vetneuro@aol.com
authors.forename: Jason
authors.initials: J
authors.lastname: Evans
authors.forename: Donald
authors.initials: D
authors.lastname: Levesque
authors.forename: Kim
authors.initials: K
authors.lastname: Knowles
authors.forename: Randy
authors.initials: R
authors.lastname: Longshore
authors.forename: Scott
authors.initials: S
authors.lastname: Plummer
mesh_terms: D000375:Aging; D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects*; D000927:Anticonvulsants / Q000627:therapeutic use*; D002493:Central Nervous System Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D003975:Diazepam / Q000627:therapeutic use*; D004285:Dogs; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000009:adverse effects*; D012189:Retrospective Studies
chemical_list: D000890:Anti-Infective Agents; D000927:Anticonvulsants; D008795:Metronidazole; D003975:Diazepam