title: Optimized spiral imaging for measurement of myocardial T2 relaxation.
abstract: Microcirculation oxygen levels and blood volumes should be reflected in measurements of myocardial T(2) relaxation. This work describes the optimization of a spiral imaging strategy for robust myocardial T(2) measurement to minimize the standard deviation of T(2) measurement (sigmaT(2)). Theoretical and experimental studies of blurring at muscle/blood interfaces enabled the derivation of parameter sets which reduce sigma T(2) to the level of 5%. T(2) relaxation mapping within healthy volunteers provided estimation of residual sigmaT(2) within the optimized technique. The standard deviation in T(2) measurement across regions of interest (ROIs) in different locations is about 9%. The standard deviation in T(2) measurement in an ROI across different time points is about 5%.
authors.affiliation: Department of Medical Biophysics, University of Toronto, Canada. wfoltz@sten.sunnybrook.utoronto.ca
authors.forename: Warren D
authors.initials: WD
authors.lastname: Foltz
authors.forename: Osama
authors.initials: O
authors.lastname: Al-Kwifi
authors.forename: Marshall S
authors.initials: MS
authors.lastname: Sussman
authors.forename: Jeff A
authors.initials: JA
authors.lastname: Stainsby
authors.forename: Graham A
authors.initials: GA
authors.lastname: Wright
mesh_terms: D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008833:Microcirculation / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000097:blood*; D019047:Phantoms, Imaging
chemical_list: D010100:Oxygen