title: Digoxin-carvedilol interactions in children.
abstract: Digoxin is often coadministered with carvedilol in children with severe ventricular failure. In eight children (age 2 weeks to 8 years), the oral clearance of digoxin decreased by half with carvedilol, and two of them had digoxin toxicity. Carvedilol increases serum concentrations of digoxin in children, and its dose may need to be reduced to avoid toxicity.
authors.affiliation: Division of Clinical Pharmacology/Toxicology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Savithiri
authors.initials: S
authors.lastname: Ratnapalan
authors.forename: Kathryn
authors.initials: K
authors.lastname: Griffiths
authors.forename: Adriana Moldovan
authors.initials: AM
authors.lastname: Costei
authors.forename: Lee
authors.initials: L
authors.lastname: Benson
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
mesh_terms: D002227:Carbazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy*; D002316:Cardiotonic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000077261:Carvedilol; D002648:Child; D002675:Child, Preschool; D004077:Digoxin / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000188:drug therapy*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011412:Propanolamines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D002227:Carbazoles; D002316:Cardiotonic Agents; D011412:Propanolamines; D014665:Vasodilator Agents; D000077261:Carvedilol; D004077:Digoxin