Salvinorins D-F, new neoclerodane diterpenoids from Salvia divinorum, and an improved method for the isolation of salvinorin A.
Three new neoclerodane diterpenoids, salvinorins D-F (4-6), have been isolated from the leaves of Salvia divinorum. The structures were elucidated by chemical and spectroscopic methods, particularly 1D and 2D NMR. A simplified isolation method using chromatography on activated carbon also gave improved yields of the controlled substance salvinorin A (1) and of salvinorin C (3).
Munro
Thomas A
TA
School of Chemistry, The University of Melbourne, Victoria, 3010, Australia.
Rizzacasa
Mark A
MA
D000107:Acetylation; D000818:Animals; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045785:Diterpenes, Clerodane; D005247:Feeding Behavior / Q000187:drug effects; D008800:Mexico; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027544:Salvia / Q000737:chemistry*; D018411:Spodoptera / Q000187:drug effects; D013712:Tenebrio / Q000187:drug effects
D004224:Diterpenes; D045785:Diterpenes, Clerodane; C478283:salvinorin D; C478285:salvinorin E; C478284:salvinorin F