title: Prevalence and prognostic significance of sMUC-1 levels in plasma cell dyscrasias.
abstract: High serum Mucin-1 (sMUC-1) levels have been shown in patients with adenocarcinoma and multiple myeloma (MM). We evaluated sMUC-1 levels in 76 patients with MM, 6 with plasma cells leukaemia (PCL) and 89 with monoclonal gammopathy of undetermined significance, to establish prevalence data and verify its possible prognostic role. Of the 171 patients, 27 [16%; 95% confidence interval (CI): 10-21%] had high sMUC-1 levels compared with healthy subjects (1.5%; 95% CI: 0-4%). Elevated sMUC-1 levels in MM and PCL patients correlated with anaemia and elevated serum lactate dehydrogenase levels; these patients showed a shorter survival than those with normal sMUC-1 levels (median overall survival: 25 vs. 49 months, P = 0.003).
authors.affiliation: Dipartimento di Oncologia ed Ematologia, Università di Modena e Reggio Emilia, Milan, Italy. luminari@unimore.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Luminari
authors.forename: Maria
authors.initials: M
authors.lastname: Goldaniga
authors.forename: Fulvia
authors.initials: F
authors.lastname: Ceccherelli
authors.forename: Andrea
authors.initials: A
authors.lastname: Guffanti
authors.forename: Emilio
authors.initials: E
authors.lastname: Bombardieri
authors.forename: Raffaella
authors.initials: R
authors.lastname: Marcheselli
authors.forename: Lilla
authors.initials: L
authors.lastname: Cro
authors.forename: Mariangela
authors.initials: M
authors.lastname: Colombi
authors.forename: Massimo
authors.initials: M
authors.lastname: Federico
authors.forename: Luca
authors.initials: L
authors.lastname: Baldini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism*; D010265:Paraproteinemias / Q000097:blood* / Q000401:mortality; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D018396:Mucin-1