title: Synthesis and structure-activity relationship of antifungal coniothyriomycin analogues.
abstract: The structure of the antifungal metabolite coniothyriomycin was systematically modified by changing the acids of the open chain imide, modification of the hydrophobicity, variation in the degree of saturation, replacement of carbons by nitrogen or oxygen, and incorporation of the open chain molecule into cyclic arrangements. Structure-activity studies showed that antifungal activity was retained by replacement of phenylacetic acids by benzoic acids in the imide structure but diminished by hydrogenation of the fumaric ester part.
authors.affiliation: Department of Chemistry, University of Paderborn, Warburger Strasse 100, 33098 Paderborn, Germany. kk@chemie.uni-paderborn.de
authors.forename: Karsten
authors.initials: K
authors.lastname: Krohn
authors.forename: Brigitta
authors.initials: B
authors.lastname: Elsässer
authors.forename: Sándor
authors.initials: S
authors.lastname: Antus
authors.forename: Krisztina
authors.initials: K
authors.lastname: Kónya
authors.forename: Eberhard
authors.initials: E
authors.lastname: Ammermann
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007094:Imides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D007094:Imides; C474719:coniothyriomycin