title: Porous ZrO2 bone scaffold coated with hydroxyapatite with fluorapatite intermediate layer.
abstract: Highly porous zirconia (ZrO(2)) bone scaffolds, fabricated by a replication technique using polymeric sponge, were coated with hydroxyapatite (HA). To prevent the chemical reactions between ZrO(2) and HA, an intermediate fluorapatite (FA) layer was introduced. The strength of the porous ZrO(2) was higher than that of pure HA by a factor of 7, suggesting the feasibility of ZrO(2) porous scaffolds as load-bearing part applications. The coated HA/FA layer, with a thickness of about 30 microm, was firmly adhered to the ZrO(2) body with a bonding strength of 22MPa. The osteoblast-like cells were attached and spread well on the coating layer throughout the porous scaffolds. The alkaline phosphatase activity of the proliferated cells on the HA/FA coated ZrO(2) was comparable to that on pure HA and higher than that on pure ZrO(2).
authors.affiliation: School of Materials Science and Engineering, Seoul National University, South Korea.
authors.forename: Hae-Won
authors.initials: HW
authors.lastname: Kim
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Lee
authors.forename: Chang-Jun
authors.initials: CJ
authors.lastname: Bae
authors.forename: Yoon-Jung
authors.initials: YJ
authors.lastname: Noh
authors.forename: Hyoun-Ee
authors.initials: HE
authors.lastname: Kim
authors.forename: Hyun-Man
authors.initials: HM
authors.lastname: Kim
authors.forename: Jea Seung
authors.initials: JS
authors.lastname: Ko
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D001031:Apatites / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D016723:Bone Remodeling; D018786:Bone Substitutes / Q000737:chemistry*; D002448:Cell Adhesion; D002455:Cell Division; D020099:Coated Materials, Biocompatible; D017886:Durapatite / Q000737:chemistry*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D013499:Surface Properties; D013718:Tensile Strength; D013997:Time Factors; D015040:Zirconium / Q000737:chemistry*
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D017886:Durapatite; D015040:Zirconium; D000469:Alkaline Phosphatase; C025105:fluorapatite; C028541:zirconium oxide