Region-specific effects of glia on neuronal induction and differentiation with a focus on dopaminergic neurons.
Radial glia (RG) are the first glial cell type to appear in the nervous system. Their broad distribution and apparent similarity hide important brain region-specific differences that are likely to be essential for development. However, recent evidence supports the stimulating concept that in addition to their classical function as neuroblast guides, RG are neuronal precursors (Malatesta et al. Development 127:5253-5263, 2000; Miyata et al. Neuron 31:727-741, 2001; Noctor et al. Nature 409:714-720, 2001; Skogh et al. Mol Cell Neurosci 17:811-820, 2001). We propose that RG not only generate and guide newborn neurons, but could also instruct their own neuronal progeny to adopt appropriate region-specific phenotypes.
Hall
Anita C
AC
Laboratory of Molecular Neurobiology, MBB, Retzius Laboratory, Karolinska Institute, Stockholm, Sweden.
Mira
Helena
H
Laboratory of Molecular Neurobiology, MBB, Retzius Laboratory, Karolinska Institute, Stockholm, Sweden.
Wagner
Joseph
J
Laboratory of Molecular Neurobiology, MBB, Retzius Laboratory, Karolinska Institute, Stockholm, Sweden.
Arenas
Ernest
E
Laboratory of Molecular Neurobiology, MBB, Retzius Laboratory, Karolinska Institute, Stockholm, Sweden.
D000818:Animals; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology* / Q000254:growth & development*; D004298:Dopamine / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D009457:Neuroglia / Q000166:cytology* / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology
D006133:Growth Substances; D004298:Dopamine