title: An alternative procedure for preparation of cefdinir.
abstract: Cefdinir, a broad spectrum third-generation cephalosporin for oral administration, was prepared by the following synthetic pathway: synthesis of diphenylmethyl 7beta-amino-3-vinyl-3-cephem-4-carboxylate hydrochloride from 7-aminocephalosporanic acid (7-ACA), preparation of sodium 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(tritylhydroxyimino) acetate from ethyl acetoacetate, coupling of both intermediaries to obtain diphenylmethyl 7beta-[2-(2-tritylaminothiazol-4-yl)-(Z)-2-tritylhydroxyimino-3-vinyl-3-cephem-4-carboxylate and final cleavage of trityl and diphenylmethyl protective groups. This procedure allows to obtain better yields of cefdinir and to avoid the use of diketene during the synthesis of this antibiotic by the previously reported method.
authors.affiliation: Department of Chemical Synthesis, Center of Pharmaceutical Chemistry, Ave. 200 y 21, Atabey, Playa, Ciudad de la Habana, Cuba.
authors.forename: Maritza
authors.initials: M
authors.lastname: González
authors.forename: Zalua
authors.initials: Z
authors.lastname: Rodríguez
authors.forename: Blanca
authors.initials: B
authors.lastname: Tolón
authors.forename: Juan C
authors.initials: JC
authors.lastname: Rodríguez
authors.forename: Hermán
authors.initials: H
authors.lastname: Velez
authors.forename: Bárbara
authors.initials: B
authors.lastname: Valdés
authors.forename: Miguel A
authors.initials: MA
authors.lastname: López
authors.forename: Adamo
authors.initials: A
authors.lastname: Fini
mesh_terms: D000077525:Cefdinir; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D002511:Cephalosporins; D000077525:Cefdinir