title: Gender differences in the membrane transport of endogenous and exogenous compounds.
abstract: Gender differences have been well described in pharmacokinetics and contribute to the interindividual variation in drug disposition, therapeutic response, and drug toxicity. Sex-related differences in the membrane transport of endogenous substrates and xenobiotics have been reported in various organs of the body including kidney, liver, intestine, and brain. These gender-related differences in transport systems could also contribute to interindividual variability in pharmacokinetics and pharmacodynamics. This review will focus on current knowledge of gender-associated differences in the transport of endogenous and exogenous compounds in a variety of body organs and will discuss the implications and the clinical significance of these observations.
authors.affiliation: Department of Pharmaceutical Sciences, 527 Hochstetter Hall, University at Buffalo, Amherst, NY 14260-1200, USA. memorris@acsu.buffalo.edu
authors.forename: Marilyn E
authors.initials: ME
authors.lastname: Morris
authors.forename: Hwa-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Predko
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001693:Biological Transport, Active; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D026901:Membrane Transport Proteins / Q000502:physiology*; D010599:Pharmacokinetics; D012727:Sex Characteristics; D013045:Species Specificity
chemical_list: D026901:Membrane Transport Proteins