title: Multicentre Italian family-based association study on tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders.
abstract: OBJECTIVE
  The aim of the present study was to investigate tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 genes in mood disorders using a family-based association approach.
  
  
  METHODS
  The sample included 134 nuclear mood disorder families, with subjects affected by bipolar disorder (n=103) or major depressive disorder (n=58). All subjects were genotyped using polymerase chain reaction techniques.
  
  
  RESULTS
  No significant transmission disequilibrium was found in the overall sample for any polymorphism. Analysis considering bipolar subjects only, or psychopathology traits as affection status did not influence the observed results.
  
  
  CONCLUSIONS
  The study could not support the involvement of tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders.
authors.affiliation: Department of Psychiatry, Vita-Salute University, San Raffaele Institute, Milan, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.forename: Cristina
authors.initials: C
authors.lastname: Cusin
authors.forename: Silvano
authors.initials: S
authors.lastname: Cristina
authors.forename: Cristina
authors.initials: C
authors.lastname: Lorenzi
authors.forename: Roberta
authors.initials: R
authors.lastname: Lilli
authors.forename: Enrico
authors.initials: E
authors.lastname: Lattuada
authors.forename: Gaetano
authors.initials: G
authors.lastname: Grieco
authors.forename: Alfredo
authors.initials: A
authors.lastname: Costa
authors.forename: Filippo
authors.initials: F
authors.lastname: Santorelli
authors.forename: Francesco
authors.initials: F
authors.lastname: Barale
authors.forename: Enrico
authors.initials: E
authors.lastname: Smeraldi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nappi
mesh_terms: D002394:Catechol O-Methyltransferase / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22; D005190:Family; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007558:Italy; D015810:Linkage Disequilibrium; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D019964:Mood Disorders / Q000201:enzymology / Q000235:genetics*; D011110:Polymorphism, Genetic; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*; D044465:White People / Q000235:genetics; D014929:Wolfram Syndrome / Q000235:genetics
chemical_list: D008565:Membrane Proteins; C114987:wolframin protein; D014446:Tyrosine 3-Monooxygenase; D002394:Catechol O-Methyltransferase