Allergic diseases, drug adverse reactions and total immunoglobulin E levels in lupus erythematosus patients.
BACKGROUND
The association of allergic diseases, drug adverse reactions and elevated total immunoglobulin E (IgE) concentration in systemic lupus erythematosus patients remains controversial. The aim of the study was to investigate the prevalence of those features in active and inactive systemic lupus erythematosus patients, and in the control group as well.


METHODS
Total IgE concentration was evaluated by enzyme-linked immunosorbent assay.


CONCLUSIONS
The results of our study revealed that concomitant allergic diseases were not more frequent in systemic lupus erythematosus patients than in the general population. Total IgE concentration was significantly higher during the active stage of the disease. Drug reactions were very frequent but not connected with IgE elevation. Our results indicate that IgE may play a role in lupus pathogenesis, especially in the active phase of the disease.
Wozniacka
Anna
A
Department of Dermatology, Medical University of Lodz, Krzemieniecka 5, 94-017 Lodz, Poland. wozniacka@bmp.net.pl
Sysa-Jedrzejowska
Anna
A
Robak
Ewa
E
Samochocki
Zbigniew
Z
Zak-Prelich
Malgorzata
M
D000208:Acute Disease; D000328:Adult; D000368:Aged; D004342:Drug Hypersensitivity / Q000453:epidemiology* / Q000276:immunology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence
D007073:Immunoglobulin E