Redox signaling of NF-kappaB by membrane NAD(P)H oxidases in normal and malignant cells.
Evidence is rapidly accumulating that low-activity NAD(P)H oxidases homologous to that in phagocytic cells generate reactive oxygen species as signaling intermediates. In this review we discuss evidence that signaling NAD(P)H oxidases in part influence normal and malignant cell division by activating the redox-regulated transcription factor nuclear factor kappaB. The roles of growth-regulatory NAD(P)H oxidases in human airway smooth muscle and malignant melanoma are used as examples.
Brar
S S
SS
Department of Internal Medicine, Carolinas Medical Center, Charlotte, North Carolina 28232, USA.
Kennedy
T P
TP
Quinn
M
M
Hoidal
J R
JR
D000818:Animals; D006801:Humans; D008545:Melanoma / Q000378:metabolism*; D009130:Muscle, Smooth / Q000166:cytology / Q000378:metabolism*; D019255:NADPH Oxidases / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D010084:Oxidation-Reduction; D012878:Skin Neoplasms / Q000378:metabolism*
D016328:NF-kappa B; D019255:NADPH Oxidases