[A new vomiting animal model--mink].
OBJECTIVE
To establish a new, reliable vomiting model in minks.


METHODS
Adult male minks (Mustela vison) were randomly divided into groups (n = 6). Cisplatin, apomorphine, copper sulfate and X-radiation were used to establish vomiting model. Retching and vomiting were observed after the vomiting models were given anti-vomiting agents. After the behavioral experiment, assay of 5-HT in the ileum was performed by immunohistologic method.


RESULTS
Cisplatin 7.5 mg.kg-1 i.p., apomorphine 1.6 mg.kg-1 s.c. and copper sulfate 40 mg.kg-1 ig were shown to evoke vomiting. Retching and vomiting were significantly inhibited in ondansetron and metoclopramide pretreated minks (P < 0.05, P < 0.01).


CONCLUSIONS
As a new vomiting model, minks may be of great value in studying vomiting mechanism and screening new antiemetic drugs.
Yue
Wang
W
Department of Pharmacology, Medical College of Qingdao University, Qingdao University, Qingdao 266021, China.
Zhang
Fang
F
Wang
Lei
L
Fang
Xuan
X
Liu
Yan-xia
YX
Minami
Masaru
M
D000818:Animals; D000932:Antiemetics / Q000627:therapeutic use; D001058:Apomorphine; D002945:Cisplatin; D019327:Copper Sulfate; D004195:Disease Models, Animal; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use; D008907:Mink; D017294:Ondansetron / Q000627:therapeutic use; D014839:Vomiting / Q000139:chemically induced* / Q000188:drug therapy
D000932:Antiemetics; D017294:Ondansetron; D008787:Metoclopramide; D019327:Copper Sulfate; D001058:Apomorphine; D002945:Cisplatin