Combined serum and ultrasound screening for detection of fetal aneuploidy.
Experience gathered over the last decade from high-risk centers provide strong evidence that mid-trimester sonographic markers are sensitive for Down syndrome prediction. More recent data indicate that combining mid trimester sonography with traditional serum markers significantly improves diagnostic accuracy over either group of markers by themselves.
Bahado-Singh
Ray
R
Department of Obstetrics and Gynecology, University of Cincinnati, OH 45267-0526, USA.
Cheng
Chih-Chien
CC
Matta
Paul
P
Small
Maria
M
Mahoney
Maurice J
MJ
D000782:Aneuploidy; D006063:Chorionic Gonadotropin / Q000097:blood; D002882:Chromosomes, Human, Pair 13; D002887:Chromosomes, Human, Pair 18; D004314:Down Syndrome / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000235:genetics*; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011262:Pregnancy Trimester, Second; D016216:Ultrasonography, Prenatal / Q000379:methods*; D000509:alpha-Fetoproteins / Q000378:metabolism
D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins