title: Novel ibuprofen potentiometric membrane sensors based on tetraphenylporphyrinato indium(III).
abstract: Two novel potentiometric membrane sensors responsive to the ibuprofen drug have been developed. These incorporate poly(vinyl chloride) and polyurethane matrix membranes containing 5,10,15,20-tetraphenylporphrinato (TPP) indium(II) ionophore plasticized with dibutylsebacate. The sensors show a near-Nernstian response with anionic slopes of -53 and -55 mV decade(-1), over the concentration range of 4.2 x 10(-6)-1.0 x 10(-2) and 3.3 x 10(-6)-1.0 x 10(-2) M ibuprofen within pH ranges of 4-9 and 5-9 for PVC and PU matrix membranes, respectively. A sensor based on a polyurethane membrane displays a lower detection limit and a wider linear working range, and a sensor based on a PVC membrane exhibits a better overall selectivity, especially in the presence of lipophilic organic anions. Both sensors are used for the quantification and quality-control assessment of ibuprofen in pharmaceutical preparations. The average recoveries are 99.1+/-0.3% and 99.3+/-0.3% for TPP In(III)-PVC and TPP In(III)-PU based membrane sensors, respectively. High selectivities towards ibuprofen in the presence of many anions, drug excipients and diluents are offered by both sensors, which exhibit a non-Hofmeister selectivity pattern.
authors.affiliation: Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt. saadsmhassan@yahoo.com
authors.forename: Saad S M
authors.initials: SS
authors.lastname: Hassan
authors.forename: Wagiha H
authors.initials: WH
authors.lastname: Mahmoud
authors.forename: Mohamed A F
authors.initials: MA
authors.lastname: Elmosallamy
authors.forename: Mahra H
authors.initials: MH
authors.lastname: Almarzooqi
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000032:analysis*; D008567:Membranes, Artificial; D008665:Metalloporphyrins / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011199:Potentiometry / Q000295:instrumentation*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008567:Membranes, Artificial; D008665:Metalloporphyrins; D004364:Pharmaceutical Preparations; C476545:tetraphenylporphyrinato indium(III); D007052:Ibuprofen