title: Modified noble plication for the prevention of intestinal intussusception after renal transplantation in dogs.
abstract: Intestinal intussusception is a frequent problem after experimental transplantation in dogs. This report describes the safety and efficacy of performing a modified Noble plication for the prevention of intussusception. Heterotopic renal transplantation and plication was performed in 20 dogs. Dogs were killed when the serum creatinine concentration exceeded 7 mg/dL because of acute rejection (19 dogs) or venous occlusion (1 dog). Gastrointestinal signs were commonly observed, but no dog experienced an intestinal intussusception, compared to 3 of 14 dogs (21%) previously treated using a similar immunosuppressive regimen. This study supports the routine use of enteroplication in dogs undergoing renal transplantation.
authors.affiliation: Comparative Transplantation Laboratory, Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA. aekyles@ucdavis.edu
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Kyles
authors.forename: Clare R
authors.initials: CR
authors.lastname: Gregory
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Griffey
authors.forename: Lynda
authors.initials: L
authors.lastname: Bernsteen
authors.forename: Randall E
authors.initials: RE
authors.lastname: Morris
mesh_terms: D000480:Alkynes; D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology; D004285:Dogs; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy; D007077:Ileal Diseases / Q000473:pathology / Q000517:prevention & control*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007443:Intussusception / Q000517:prevention & control*; D007555:Isoxazoles / Q000494:pharmacology; D016030:Kidney Transplantation / Q000379:methods*; D009570:Nitriles; D011183:Postoperative Complications / Q000517:prevention & control; D013514:Surgical Procedures, Operative
chemical_list: D000480:Alkynes; D007166:Immunosuppressive Agents; D007555:Isoxazoles; D009570:Nitriles; C115284:2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-hepten-6-ynamide; D016572:Cyclosporine