title: Ouabain as a mammalian hormone.
abstract: Endogenous ouabain changes rapidly in humans and dogs upon physical exercise and is under the control of epinephrine and angiotensin II. Hence, the steroid acts as a rapidly acting hormone. A search for a specific binding globulin for cardiac glycosides in bovine plasma resulted in the identification of the d allotype of the micro chain of IgM whose hydrophobic surfaces interact with cardiotonic steroids and cholesterol. Such IgM complexes might be involved in the hepatic elimination of cardiotonic steroids. Thus, differences in the signaling cascade starting at Na(+),K(+)-ATPase must explain any differences in the action of ouabain and digoxin in the genesis of arterial hypertension.
authors.affiliation: Institute of Biochemistry and Endocrinology, Justus-Liebig-University Giessen, Germany. wilhelm.schoner@vetmed.uni-giessen.de
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Schoner
authors.forename: Natali
authors.initials: N
authors.lastname: Bauer
authors.forename: Jochen
authors.initials: J
authors.lastname: Müller-Ehmsen
authors.forename: Ulrike
authors.initials: U
authors.lastname: Krämer
authors.forename: Njde
authors.initials: N
authors.lastname: Hambarchian
authors.forename: Robert
authors.initials: R
authors.lastname: Schwinger
authors.forename: Hans
authors.initials: H
authors.lastname: Moeller
authors.forename: Holger
authors.initials: H
authors.lastname: Kost
authors.forename: Christine
authors.initials: C
authors.lastname: Weitkamp
authors.forename: Thomas
authors.initials: T
authors.lastname: Schweitzer
authors.forename: Ulrike
authors.initials: U
authors.lastname: Kirch
authors.forename: Horst
authors.initials: H
authors.lastname: Neu
authors.forename: Ernst-Güngther
authors.initials: EG
authors.lastname: Grünbaum
mesh_terms: D000328:Adult; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002301:Cardiac Glycosides / Q000378:metabolism*; D002316:Cardiotonic Agents; D002417:Cattle; D002784:Cholesterol / Q000502:physiology; D004285:Dogs; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006728:Hormones / Q000097:blood / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007148:Immunoglobulin mu-Chains / Q000097:blood; D008875:Middle Aged; D010042:Ouabain / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D012016:Reference Values; D013256:Steroids / Q000502:physiology
chemical_list: D002301:Cardiac Glycosides; D002316:Cardiotonic Agents; D006728:Hormones; D007148:Immunoglobulin mu-Chains; D013256:Steroids; D010042:Ouabain; D002784:Cholesterol