title: What do we mean by biological complexity?
abstract: The purpose of the present paper is to offer a precise definition of the concepts of integration, emergence and complexity in biological networks through the use of the information theory. If two distinct properties of a network are expressed by two discrete variables, the classical subadditivity principle of Shannon's information theory applies when all the nodes of the network are associated with these properties. If not, the subadditivity principle may not apply. This situation is often to be encountered with enzyme and metabolic networks, for some nodes may well not be associated with these two properties. This is precisely what is occurring with an enzyme that binds randomly its two substrates. This situation implies that an enzyme, or a metabolic network, may display a joint entropy equal, smaller, or larger than the corresponding sum of individual entropies of component sub-systems. In the first case, the collective properties of the network can be reduced to the individual properties of its components. Moreover, the network is devoid of any information. In the second case, the system displays integration effects, behaves as a coherent whole, and has positive information. But if the joint entropy of the network is smaller than the sum of the individual entropies of its components, then the system has emergent collective properties and can be considered complex. Moreover, under these conditions, its information is negative. The extent of negative information is enhanced if the enzyme, or the metabolic network, is far away from equilibrium.
authors.affiliation: Institut Jacques-Monod, CNRS, université Paris-7, 2, place Jussieu, 75251 Paris cedex 05, France. meunier@ijm.jussieu.fr
authors.forename: Jacques
authors.initials: J
authors.lastname: Ricard
mesh_terms: D019277:Entropy; D004798:Enzymes / Q000378:metabolism; D007257:Information Theory; D008954:Models, Biological
chemical_list: D004798:Enzymes