Cell-cell adhesion in the normal ovary and ovarian tumors of epithelial origin; an exception to the rule.
Cells are held together either by direct cell-cell contact or adhesion to extra-cellular matrix. Cell-cell adhesion in epithelial cell sheets consists of junctions, i.e. tight-, adherens- and gap-junctions. The adherens junctions, which are build up by the cadherin/catenin complex, are the main topic of this review, especially the aspect of its role in ovarian tumor biology. The ovarian surface epithelium is the origin for approximately 90% of the malignant ovarian tumors. The tumors arise from the inclusion cysts, localized in the ovarian stroma and grow solid, cystic or in mixed formations. Intra-abdominal spread of the ovarian cancer is common and this is a process that theoretically could be closely connected with impaired cell-cell adhesion. However, as we stand today, descriptive and functional studies on the cadherin-catenin complex and its cell signaling role in ovarian tumorigenesis reveals data that suggests a conversion of the mesothelial-like cells of the ovarian surface to a more epithelial phenotype with normal cell-cell adhesion prior to tumor differentiation. In later stages, invasive ovarian tumors still strongly express several cadherins, which are contrary to many other tumors, i.e. prostate and thyroid adenocarcinomas.
Sundfeldt
Karin
K
Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden. karin.sundfeldt@obgyn.gu.se
D022005:Adherens Junctions / Q000502:physiology; D015820:Cadherins / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology*; D004847:Epithelial Cells / Q000166:cytology / Q000473:pathology; D005260:Female; D006801:Humans; D008954:Models, Biological; D009375:Neoplasms, Glandular and Epithelial / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D010051:Ovarian Neoplasms / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D010053:Ovary / Q000166:cytology*
D015820:Cadherins