[The reaction of cell population to low level of irradiation].
The results of long-term investigations of the effectivity of low level irradiation (below 0.5 Gy) carried out on the cells in culture and blood human lymphocytes (adults and children) have been brought. In the experiments conducted in the laboratory conditions and in the contaminated with radionuclides regions (after Chernobyl accident) the genomic instability have been discovered. The cell manifestations of the genomic instability have been registered in the progeny of irradiated cells as the decreasing of proliferative activity, the increasing of the frequency of cells with micronuclei, the increasing of cells with sister chromatid exchanges, the late cell death, the absence of the adaptive response ability, the enhancement of the radiosensitivity. The results of the investigations of the adaptive response of blood lymphocytes have been presented. It was shown that in all populations investigated there are individuals without the adaptive response and the individuals with the enhancement of radiosensitivity after adaptive irradiation (0.05 Gy). On the basis of own results and the data of literature the possible mechanisms of low level irradiation effects are discussed. The conclusion is that: a. The population with new properties can be formed after low level irradiation; b. The effects and mechanisms of this effect realization can be different from that after irradiation with high doses.
Pelevina
I I
II
Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, 119991 Russia. pele@chph.ras.ru
Aleshchenko
A V
AV
Antoshchina
M M
MM
Gotlib
V Ia
VIa
Kudriashova
O V
OV
Semenova
L P
LP
Serebrianyĭ
A M
AM
D000222:Adaptation, Physiological; D000328:Adult; D000818:Animals; D016923:Cell Death; D002478:Cells, Cultured; D002648:Child; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D006367:HeLa Cells; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects; D011210:Power Plants; D011836:Radiation Tolerance; D018788:Radioactive Hazard Release; D012854:Sister Chromatid Exchange; D014455:Ukraine