title: Cord blood thyroid-stimulating hormone level in high-risk pregnancies.
abstract: OBJECTIVE
  To evaluate the effect of various antepartum conditions on cord blood thyroid-stimulating hormone (TSH) level.
  
  
  METHODS
  The study group consisted of 24,892 consecutive singleton deliveries over a period of 4 years. The effect of preeclampsia, glucose intolerance, maternal medical diseases, and antepartum hemorrhage of unknown origin (APHUO) on cord blood TSH level were assessed by univariate analysis and linear regression.
  
  
  RESULTS
  After controlling for potential confounders, there was a significant independent association between cord blood TSH level and preeclampsia (P=0.043), glucose intolerance (P=0.015), and maternal medical diseases (P=0.022). Antepartum hemorrhage of unknown origin was not associated with a higher cord blood TSH level.
  
  
  CONCLUSIONS
  Cord blood TSH level was significantly elevated in various adverse antepartum conditions. This may be related to the placental insufficiency and fetal hypoxia commonly found in these high-risk pregnancies.
authors.affiliation: Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Sing Street, Shatin, Hong Kong, China. lyschan@cuhk.edu.hk
authors.forename: Louis Yik-Si
authors.initials: LY
authors.lastname: Chan
authors.forename: Pui Yu
authors.initials: PY
authors.lastname: Chiu
authors.forename: Tze Kin
authors.initials: TK
authors.lastname: Lau
mesh_terms: D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D016014:Linear Models; D008297:Male; D011247:Pregnancy; D018566:Pregnancy, High-Risk / Q000097:blood*; D012016:Reference Values; D012189:Retrospective Studies; D012307:Risk Factors; D013972:Thyrotropin / Q000097:blood*
chemical_list: D013972:Thyrotropin