Cytotoxic pentacyclic triterpenes from Combretum nigricans.
A new pentacyclic triterpene, 11alpha-acetoxy-20,24-epoxy-25-hydroxy-dammar-3-one (1), has been isolated from the African tree Combretum nigricans, together with the known corresponding diol, 20,24-epoxy-11alpha, 25-dihydroxy-dammar-3-one (2). They are responsible, at least in part, for the cytotoxic activity of the methanolic extract of the plant.
Simon
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G
Unibioscreen SA, EEBIC, 40 Av. J. Wybran, Brussels 1070, Belgium.
Dewelle
J
J
Nacoulma
O
O
Guissou
P
P
Kiss
R
R
Daloze
D
D
Braekman
J C
JC
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D029765:Combretum; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D014315:Triterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects; D000097669:Dammaranes
D000970:Antineoplastic Agents; D010936:Plant Extracts; D014315:Triterpenes; D000097669:Dammaranes