Cord blood thyroid-stimulating hormone level in high-risk pregnancies.
OBJECTIVE
To evaluate the effect of various antepartum conditions on cord blood thyroid-stimulating hormone (TSH) level.


METHODS
The study group consisted of 24,892 consecutive singleton deliveries over a period of 4 years. The effect of preeclampsia, glucose intolerance, maternal medical diseases, and antepartum hemorrhage of unknown origin (APHUO) on cord blood TSH level were assessed by univariate analysis and linear regression.


RESULTS
After controlling for potential confounders, there was a significant independent association between cord blood TSH level and preeclampsia (P=0.043), glucose intolerance (P=0.015), and maternal medical diseases (P=0.022). Antepartum hemorrhage of unknown origin was not associated with a higher cord blood TSH level.


CONCLUSIONS
Cord blood TSH level was significantly elevated in various adverse antepartum conditions. This may be related to the placental insufficiency and fetal hypoxia commonly found in these high-risk pregnancies.
Chan
Louis Yik-Si
LY
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Sing Street, Shatin, Hong Kong, China. lyschan@cuhk.edu.hk
Chiu
Pui Yu
PY
Lau
Tze Kin
TK
D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D016014:Linear Models; D008297:Male; D011247:Pregnancy; D018566:Pregnancy, High-Risk / Q000097:blood*; D012016:Reference Values; D012189:Retrospective Studies; D012307:Risk Factors; D013972:Thyrotropin / Q000097:blood*
D013972:Thyrotropin