Characteristics of prolonged afterdischarges in children with malformations of cortical development.
We investigated aberrant cortical excitability in malformations of cortical development From subdural electrodes, we recorded afterdischarges lasting > or = 6 seconds in 12 of 13 patients with malformations of cortical development and 6 of 10 pediatric patients with nonmalformations of cortical development and reviewed amperage thresholds, distribution of afterdischarges, and motor responses. In patients with malformation of cortical development, motor response thresholds were high; afterdischarge and motor response thresholds, which essentially overlapped, inversely correlated with age (P < .01); afterdischarge thresholds declined with age; and 8 patients showed afterdischarges in remote sites. In nonmalformation of cortical development, afterdischarge thresholds did not significantly correlate with age; motor response thresholds tended to decline with age; and 2 patients had remote afterdischarges. Adolescent patients with malformations of cortical development had lower afterdischarge thresholds than adolescents with nonmalformation of cortical development (P < .05). From their high afterdischarge (and motor response) thresholds, we concluded that preadolescent patients with malformation of cortical development have less excitable, immature cortices, whereas adolescent patients with malformation of cortical development with low afterdischarge thresholds have hyperexcitable cortices. Remote afterdischarges over focal dysplastic cortex suggest aberrant cortical excitability and neural circuits.
Chitoku
Shiro
S
Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON.
Otsubo
Hiroshi
H
Harada
Yu
Y
Jay
Venita
V
Rutka
James T
JT
Weiss
Shelly K
SK
Elliott
Irene
I
Ochi
Ayako
A
Kitayama
Masaomi
M
Snead
O Carter
OC
D000293:Adolescent; D000367:Age Factors; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000254:growth & development* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004056:Differential Threshold / Q000502:physiology; D004558:Electric Stimulation; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009421:Nervous System Malformations / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D012189:Retrospective Studies; D013997:Time Factors; D014055:Tomography, Emission-Computed