Concise enantioselective syntheses of quinolactacins A and B through alternative Winterfeldt oxidation.
Enantioselective total syntheses of (+)-quinolactacin B and (+)-quinolactacin A2 through asymmetric Pictet-Spengler cyclization and KO(2) oxidation-an alternative Winterfeldt condition-are described.
Zhang
Xuqing
X
Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, L. L. C., 1000 Route 202, Box 300, Raritan, New Jersey 08869, USA. xzhang5@prdus.jnj.com
Jiang
Weiqin
W
Sui
Zhihua
Z
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010407:Penicillium / Q000737:chemistry; D015363:Quinolones / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D015363:Quinolones; C444201:quinolactacin A2; C420724:quinolactacin B