title: Reproductive function after treatment of malignant germ cell ovarian tumors.
abstract: The outcome and reproductive function were examined among patients with malignant ovarian germ cell tumors treated since 1980. Between 1980 and 2001, fertility-sparing surgery was performed in 26 women, 23 of whom received adjuvant chemotherapy. With a median follow-up of 66.6 months, all patients have been alive, with histological types of 6 immature teratomas, 8 dysgerminomas, 6 yolk sac tumors, and 6 mixed types. Clinical stages were involved of 17 early stage and 9 advanced stage patients. After treatment, 20 women out of 26 recovered menstruation within 6 months. During follow-up, two chemotherapy-untreated and one treated patients experienced 4 conceptions in total. A treated patient conceived but selected artificial termination by affection of chemotherapy. Conservative surgery with adjuvant chemotherapy is the standard approach to treat patients with malignant ovarian germ cell tumors. In these 20 years, we experienced no delivery, so that fertility seems to be seriously affected by treatments.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Sapporo Medical University, South 1 West 16, Chuou-ku, Sapporo 060-0061, Japan. sagaes@sapmed.ac.jp
authors.forename: Satoru
authors.initials: S
authors.lastname: Sagae
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sasaki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nishioka
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Terasawa
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kudo
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005298:Fertility / Q000187:drug effects; D018237:Germinoma / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D008598:Menstruation / Q000187:drug effects; D010051:Ovarian Neoplasms / Q000503:physiopathology* / Q000628:therapy*; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents