Highly active antiretroviral therapy and cardiovascular complications in HIV-infected patients.
Highly active antiretroviral therapy (HAART) has prolonged many patients' lives, but many cardiac sequelae of HIV are not affected by HAART and continue to develop even with treatment. In addition, HAART itself causes in a high proportion of patients a metabolic syndrome, characterized by lipodystrophy/ lipoatrophy, dyslipidemia and insulin resistance that may be associated with an increase in peripheral artery and coronary artery diseases. Careful cardiovascular evaluation in the course of HIV disease can identify cardiac complications early enough to treat. All HIV-infected patients who are either candidates to antiretroviral therapy or who are already under treatment should undergo an assessment that includes the evaluation of the cardiovascular risk with the available guidelines and the interactions between antiretrovirals and drugs commonly used to treat cardiovascular disease.
Barbaro
Giuseppe
G
Department of Medical Pathophysiology, University La Sapienza, Rome, Italy. g.barbaro@tin.it
Klatt
Edward C
EC
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control; D004347:Drug Interactions; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy / Q000209:etiology; D007333:Insulin Resistance; D008060:Lipodystrophy / Q000209:etiology; D008659:Metabolic Diseases / Q000209:etiology; D012307:Risk Factors