title: Severe systemic reaction to (99m)Tc-methylene diphosphonate: a case report.
abstract: We report an unusual severe systemic reaction that occurred in a woman after a (99m)Tc-methylene diphosphonate bone scan and for which no alternative explanation could be found. The bone scintigram showed diffusely increased uptake in the liver and kidneys accompanied by reversible dysfunction of these organs and dermatologic manifestations. We speculate that an immune-mediated mechanism may have caused this unusual reaction.
authors.affiliation: Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom. kottekkattu.balan@addenbrookes.nhs.uk
authors.forename: Kottekkattu K
authors.initials: KK
authors.lastname: Balan
authors.forename: Arabinda K
authors.initials: AK
authors.lastname: Choudhary
authors.forename: Anupama
authors.initials: A
authors.lastname: Balan
authors.forename: Gordon
authors.initials: G
authors.lastname: Wishart
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D001943:Breast Neoplasms / Q000000981:diagnostic imaging; D005260:Female; D006530:Hepatorenal Syndrome / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000009:adverse effects / Q000493:pharmacokinetics; D013669:Technetium Tc 99m Medronate / Q000009:adverse effects* / Q000493:pharmacokinetics; D014915:Whole-Body Counting
chemical_list: D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate