A new hypothesis for how sex steroid hormones regulate bone mass.
It has been proposed - but remains controversial - that estrogen's effects on various tissues may be mediated by different cell signaling pathways. Researchers have identified a synthetic ligand that activates only a subset of these pathways, suggesting that bypass of the traditional estrogen pathway can prevent bone loss without associated side effects on reproductive organs.
Lorenzo
Joseph
J
The University of Connecticut Health Center, Farmington, Connecticut 06030-1317, USA. jlorenzo@nso2.uchc.edu
D000818:Animals; D017209:Apoptosis; D001842:Bone and Bones / Q000502:physiology*; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D006801:Humans; D008024:Ligands; D008297:Male; D008954:Models, Biological; D015398:Signal Transduction; D013256:Steroids / Q000378:metabolism* / Q000502:physiology*
D004967:Estrogens; D008024:Ligands; D013256:Steroids