title: [Antioxidant effect of Ganoderma polysaccharide peptide].
abstract: OBJECTIVE
  To study the antioxidant effect of Ganoderma polysaccharide peptide (GLPP) and its mechanism.
  
  
  METHODS
  Copper was used as oxidant to induce low lipoprotein (LDL) oxidative modification, and alloxan was given i.v. to induce reactive oxygen species (ROS) injury in mice.
  
  
  RESULTS
  GLPP decreased oxidation of LDL and the relative electrophoretic mobility (REM) of oxidative product of LDL. After GLPP was given i.p. for 20 days, the concentration of malondialdehyde(MDA) in serum and heart of mice was decreased. The GSHpx enzyme activity was increased, while the SOD level was decreased. The catalase(CAT) levels were not significantly changed by GLPP.
  
  
  CONCLUSIONS
  GLPP showed antioxidant effect by scavenging ROS or enhancing the enzyme activity of GSHpx in vivo and in vitro.
authors.affiliation: Department of Pharmacology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100083, China.
authors.forename: Yu-hong
authors.initials: YH
authors.lastname: You
authors.forename: Zhi-bin
authors.initials: ZB
authors.lastname: Lin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry; D011509:Proteoglycans / Q000302:isolation & purification / Q000494:pharmacology*; D011897:Random Allocation; D020940:Reishi / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL; D011509:Proteoglycans; C093216:polysaccharide peptide; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase