LOH of PTPRJ occurs early in colorectal cancer and is associated with chromosomal loss of 18q12-21.
Recently, the gene PTPRJ (protein tyrosine phosphatase receptor type J) was identified as the candidate gene for the mouse colon cancer susceptibility locus Scc1. Its human homologue PTPRJ is frequently deleted in several cancer types, including colorectal cancer. To elucidate the role of PTPRJ loss in different stages of colorectal cancer and in its pathways of progression, we expanded the previously published comparative genomic hybridization results with novel data on loss of heterozygosity (LOH) at the PTPRJ locus. We identified a strong association between the LOH of PTPRJ and the loss of chromosomal region 18q12-21 (P=0.009). This observation is specific for progressed colorectal adenomas, suggesting that an interaction between LOH of PTPRJ and loss of 18q12-21 may be involved in the development of a more progressed form of adenomas.
Ruivenkamp
Claudia
C
Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Hermsen
Mario
M
Postma
Cindy
C
Klous
Anita
A
Baak
Jan
J
Meijer
Gerrit
G
Demant
Peter
P
D000236:Adenoma / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D002887:Chromosomes, Human, Pair 18; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D019656:Loss of Heterozygosity; D051379:Mice; D018895:Microsatellite Repeats; D009693:Nucleic Acid Hybridization; D017027:Protein Tyrosine Phosphatases / Q000235:genetics* / Q000378:metabolism; D054631:Receptor-Like Protein Tyrosine Phosphatases, Class 3
C486288:PTPRJ protein, human; D017027:Protein Tyrosine Phosphatases; C098066:Ptprj protein, mouse; D054631:Receptor-Like Protein Tyrosine Phosphatases, Class 3