title: Actin comet tails, endosomes and endosymbionts.
abstract: The Arp2/3 complex consists of seven highly conserved and tightly associated subunits, two of which are the actin-related proteins Arp2 and Arp3. One of the best-studied functions of the Arp2/3 complex is to stimulate actin nucleation and force production at the leading edge of motile cells. What is now clear is that Arp2/3-complex-mediated force production drives many intracellular movements, including movement of bacterial pathogens in infected host cells, internalization of extracellular materials via phagocytosis and endocytosis, and movement of mitochondria during cell division in budding yeast. Here, we describe recent advances in the mechanisms underlying Arp2/3 complex-driven intracellular movement.
authors.affiliation: Department of Anatomy and Cell Biology, Columbia University, New York, NY, USA. lap5@columbia.edu
authors.forename: Kammy
authors.initials: K
authors.lastname: Fehrenbacher
authors.forename: Thomas
authors.initials: T
authors.lastname: Huckaba
authors.forename: Hyeong-Cheol
authors.initials: HC
authors.lastname: Yang
authors.forename: Istvan
authors.initials: I
authors.lastname: Boldogh
authors.forename: Liza
authors.initials: L
authors.lastname: Pon
mesh_terms: D000199:Actins / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology*; D015388:Organelles / Q000502:physiology*
chemical_list: D000199:Actins