Stability and antibacterial activity of cefepime during continuous infusion.
The stability of cefepime during simulated continuous infusion was determined with a motorized portable infusion pump worn over a period of 24 to 36 h. Susceptibility testing on cefepime solutions over time indicates that the degradation products do not exhibit antibacterial activity. Cefepime stability at 24 h following continuous infusion was 94.3% +/- 1.0%, which supports the use of continuous infusion.
Sprauten
Pål F
PF
University of Oslo, Oslo, Norway.
Beringer
Paul M
PM
Louie
Stan G
SG
Synold
Timothy W
TW
Gill
Mark A
MA
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D000077723:Cefepime; D002511:Cephalosporins / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D004355:Drug Stability; D004356:Drug Storage; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000077723:Cefepime