Preliminary in vitro studies on the Marsypianthes chamaedrys (boia-caá) extracts at fibrinoclotting induced by snake venoms.
The extract of Marsypianthes chamaedrys, a plant used against snakebites, in the present study was shown to inhibit fibrinoclotting induced by several Brazilian snake venoms or thrombin. These data indicate that this extract affected thrombin-like enzymes. In this first report we determine some features of the components present in the extract regarding the antifibrinoclotting action. Our results show that active components responsible for those effects are thermo-resistant and are concentrated in the methanolic fraction.
Castro
K N C
KN
Departamento de Bioquímica Médica, ICB/CCS, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.
Carvalho
A L O
AL
Almeida
A P
AP
Oliveira
D B
DB
Borba
H R
HR
Costa
S S
SS
Zingali
R B
RB
D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D001938:Brazil; D004305:Dose-Response Relationship, Drug; D005337:Fibrin / Q000187:drug effects; D020128:Inhibitory Concentration 50; D019686:Lamiaceae; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D012910:Snake Venoms / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012911:Snakes; D013917:Thrombin / Q000494:pharmacology
D000925:Anticoagulants; D010936:Plant Extracts; D012910:Snake Venoms; D005337:Fibrin; D013917:Thrombin