Herbal supplements and skin testing: the lack of effect of commonly used herbal supplements on histamine skin prick testing.
BACKGROUND
The use of herbal supplements is common, yet little is known about their pharmacologic properties. The purpose of this study was to assess the effects of 23 commonly used herbal supplements on histamine skin prick testing (SPT).


METHODS
Fifteen healthy volunteers participated in a double-blind, placebo-controlled, single-dose, crossover study. Wheal and flare responses to SPT with histamine phosphate (1 mg/ml) were measured before and 4 h after administration of each of the 23 popular herbal supplements, fexofenadine (60 mg) and placebo. Wheal and flare areas were recorded with tracings performed 10 min after the prick test and measured with a PC-digitizer using stereometric software.


RESULTS
Fexofenadine significantly suppressed the wheal (P < 0.001) and flare (P = 0.02) areas compared with placebo. None of the herbal supplements caused significant suppression of the wheal and flare areas compared with placebo (P > 0.10).


CONCLUSIONS
When taken in single-doses, the popular herbal supplements tested did not significantly affect the histamine skin response. Therefore, it seems unnecessary for clinicians to ask patients to discontinue these herbal supplements prior to allergy skin testing.
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Wilford Hall Medical Center, Department of Allergy and Immunology, Lackland AFB, TX 78236, USA.
Napoli
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DC
Hagan
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LL
D018592:Cross-Over Studies; D004311:Double-Blind Method; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006632:Histamine; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006801:Humans; D028321:Plant Preparations / Q000009:adverse effects / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests; D016593:Terfenadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D006634:Histamine H1 Antagonists; D028321:Plant Preparations; D016593:Terfenadine; D006632:Histamine; C093230:fexofenadine