New sesquiterpene quinols from a Micronesian sponge, Aka sp.
Three new sesquiterpene quinols (1, 2, and 5) and two known ones (3 and 4) were isolated along with halistanol sulfate (6) from a marine sponge of the genus Aka collected from Yap Island, Federated States of Micronesia. Their structures were determined from spectral data, and the structure of siphonodictyal C (3) was revised. Sulfates 3 and 6 inhibit CDK4/cyclin D1 complexation, whereas 1 and 4 do not.
Mukku
Venugopal J R V
VJ
Department of Chemistry and Biochemistry, University of Oklahoma, Norman 73019, USA.
Edrada
Ru A
RA
Schmitz
Francis J
FJ
Shanks
Michelle Kelly
MK
Chaudhuri
Babathosh
B
Fabbro
Doriano
D
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D019938:Cyclin D1 / Q000187:drug effects; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008849:Micronesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D011518:Proto-Oncogene Proteins; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D011518:Proto-Oncogene Proteins; D012717:Sesquiterpenes; D019938:Cyclin D1; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases