title: [Role of oxidative stress in heart failure].
abstract: Recent experimental and clinical studies have suggested that oxidative stress is enhanced in heart failure. The production of oxygen radicals is increased in the failing heart whereas antioxidant enzyme activities are preserved normal. Mitochondrial electron transport is an enzymatic source of oxygen radical generation and also a target against oxidant-induced damage. Chronic increases in oxygen radical production in the mitochondria can lead to a catastrophic cycle of mitochondrial DNA damage as well as functional decline, further radical generation, and cellular injury. These cellular events might play an important role in the development and progression of myocardial remodeling and failure.
authors.affiliation: Department of Cardiovascular Medicine, Kyushu University.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsutsui
mesh_terms: D004249:DNA Damage; D004272:DNA, Mitochondrial; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D013890:Thiourea / Q000031:analogs & derivatives* / Q000627:therapeutic use; D020257:Ventricular Remodeling
chemical_list: D004272:DNA, Mitochondrial; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; C038983:1,3-dimethylthiourea; D013890:Thiourea