title: New unusual iridoids from the leaves of noni (Morinda citrifolia L.) show inhibitory effect on ultraviolet B-induced transcriptional activator protein-1 (AP-1) activity.
abstract: A novel iridoid dimer in whose structure the two iridoid units are connected by a rare ether group, together with two new unusual iridoids showing significant inhibition of UVB-induced Activator Protein-1 (AP-1) activity in cell cultures, have been isolated from the leaves of noni (Morinda citrifolia L.). Their structures were determined on the basis of detailed high-field 1D and 2D spectral analysis. Their inhibitory effect on UVB-induced transcriptional Activator Protein-1 (AP-1) activity are also discussed.
authors.affiliation: Department of Food Science and Center for Advanced Food Technology, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901-8520, USA. ssang@rci.rutgers.edu
authors.forename: Shengmin
authors.initials: S
authors.lastname: Sang
authors.forename: Guangming
authors.initials: G
authors.lastname: Liu
authors.forename: Kan
authors.initials: K
authors.lastname: He
authors.forename: Nanqun
authors.initials: N
authors.lastname: Zhu
authors.forename: Zigang
authors.initials: Z
authors.lastname: Dong
authors.forename: Qunyi
authors.initials: Q
authors.lastname: Zheng
authors.forename: Robert T
authors.initials: RT
authors.lastname: Rosen
authors.forename: Chi-Tang
authors.initials: CT
authors.lastname: Ho
mesh_terms: D000818:Animals; D002460:Cell Line; D019281:Dimerization; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D032066:Morinda / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D018808:Transcription Factor AP-1 / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D039823:Iridoids; D018808:Transcription Factor AP-1