Does the melanin-concentrating hormone antagonist SNAP-7941 deserve 3As?
Melanin-concentrating hormone (MCH) is orexigenic (stimulates food intake). Two receptors for MCH have been identified in humans, MCH1-R and MCH2-R. SNAP-7941 is a small molecule MCH1-R antagonist. SNAP-7941 inhibits MCH-induced food intake in rats. SNAP-7941 alone reduced weight gain in young growing rats and in mature rats fed a high-fat diet. Preliminary testing with SNAP7941 in animal models of depression and anxiety shows it has antidepressant and anxiolytic effects. SNAP7941 should undergo further development as an anorectic, antidepressant and anxiolytic.
Doggrell
Sheila A
SA
School of Biomedical Sciences, The University of Queensland, QLD 4072, Australia. s_doggrell@yahoo.com
D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D001067:Appetite Depressants / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D007028:Hypothalamic Hormones / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D010907:Pituitary Hormones / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D001067:Appetite Depressants; D007028:Hypothalamic Hormones; D008543:Melanins; D010880:Piperidines; D010907:Pituitary Hormones; D011743:Pyrimidines; C464854:SNAP7941; C019463:melanin-concentrating hormone