Interactions of oxovanadium(IV) and the quinolone family member--ciprofloxacin.
The interactions of quinolone ciprofloxacin (cfH) and oxovanadium(IV) were studied by various methods. Green crystals of a complex [V(IV)O(cf)(2)(H(2)O)] were isolated and the molecular connectivities established, although the crystal structure was not perfectly refined due to the instability of the crystals. Based on a plausible interpretation of the data sets, two cf anions bidentately coordinate to a vanadyl cation through carboxylate and carbonyl oxygen atoms; in addition, there is a water molecule in the coordination sphere. Solution techniques (cyclic voltammetry, electronic and electron paramagnetic resonance spectroscopy, potentiometric measurements) confirmed the presence of various species in the solution, the composition of which strongly depends on the conditions in the system. The antibacterial activity of the complex against various microorganisms was tested and it was established that its activity is similar to that of free ciprofloxacin.
Turel
Iztok
I
Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, 1000 Ljubljana, Slovenia. iztok.turel@uni-lj.si
Golobic
Amalija
A
Klavzar
Ales
A
Pihlar
Boris
B
Buglyó
Péter
P
Tolis
Evangelos
E
Rehder
Dieter
D
Sepcić
Kristina
K
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004563:Electrochemistry / Q000379:methods; D004578:Electron Spin Resonance Spectroscopy; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D010084:Oxidation-Reduction; D013056:Spectrophotometry, Ultraviolet; D014638:Vanadates / Q000737:chemistry*
D000890:Anti-Infective Agents; D009942:Organometallic Compounds; D014638:Vanadates; D002939:Ciprofloxacin