title: Factor V inhibitor after injection of human thrombin (tissucol) into a bleeding peptic ulcer.
abstract: Endoscopic injection of fibrin glue into a bleeding peptic ulcer is an effective and safe treatment modality. The present report describes a patient who developed rectal bleeding from an arteriovenous malformation after endoscopic injection of fibrin glue containing human thrombin into a gastric ulcer. Additional laboratory investigations revealed the presence of an inhibitor against coagulation factor V, which resulted in severe coagulopathy, triggering the bleeding. Acquired factor V inhibitors have frequently been reported with the use of bovine thrombin, but to our knowledge, they have never been documented in patients exposed to human thrombin. Endoscopists should be aware of this rare, but potentially serious, complication.
authors.affiliation: Department of Internal Medicine, University Hospital, Free University of Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Caers
authors.forename: A
authors.initials: A
authors.lastname: Reekmans
authors.forename: K
authors.initials: K
authors.lastname: Jochmans
authors.forename: S
authors.initials: S
authors.lastname: Naegels
authors.forename: F
authors.initials: F
authors.lastname: Mana
authors.forename: D
authors.initials: D
authors.lastname: Urbain
authors.forename: H
authors.initials: H
authors.lastname: Reynaert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001778:Blood Coagulation Disorders / Q000209:etiology* / Q000628:therapy; D001780:Blood Coagulation Tests; D016099:Endoscopy, Gastrointestinal; D005165:Factor V / Q000037:antagonists & inhibitors*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000009:adverse effects; D006490:Hemostatics / Q000009:adverse effects*; D006801:Humans; D010438:Peptic Ulcer Hemorrhage / Q000628:therapy*; D013917:Thrombin / Q000009:adverse effects* / Q000276:immunology
chemical_list: D015718:Fibrin Tissue Adhesive; D006490:Hemostatics; D005165:Factor V; D013917:Thrombin