title: Observations on the HLA-A2403 specificity.
abstract: We found HLA-A*2423 in a subject possessing the HLA-A2403 specificity. Consequently we delineated the A*24 alleles of 41 subjects previously assigned as 'A2403' by serology and/or 'low-resolution' PCR-SSP (allele group: A*2403/10/18/22/23/33) and found that 36 were A*2403, 3 were A*2410 and 2 were A*2433. The A*2410 and A*2433 subjects also typed as A2403. Several likely A*2410/23/33-bearing haplotypes were identified and the frequency of the A*2403/10/18/22/23/33 alleles was determined in 26,826 Welsh blood donors. We suggest that HLA-A9/A24 antibodies against epitope(s) involving 166D and 167G will fail to react with all A*2403/10/18/22/23/33 products. As it is this 'short' A9/A24 serological reactivity that defines HLA-A2403 all these products will be serologically designated as HLA-A2403.
authors.affiliation: Welsh Transplantation and Immunogenetics Laboratory, Welsh Blood Service, Pontyclun, UK.
authors.forename: J
authors.initials: J
authors.lastname: Street
authors.forename: L
authors.initials: L
authors.lastname: Hammond
authors.forename: J
authors.initials: J
authors.lastname: Downing
authors.forename: J
authors.initials: J
authors.lastname: Thompson
authors.forename: C
authors.initials: C
authors.lastname: Darke
mesh_terms: D015234:HLA-A Antigens / Q000276:immunology*; D006801:Humans
chemical_list: D015234:HLA-A Antigens