[Cyclines and acne: pay attention to adverse drug reactions! A recent literature review].
OBJECTIVE
Cyclines are broad-spectrum antibiotics often used in acne. Side effects might occur precociously or more insidiously during long term treatment such in acne. The aim of this study is to review all adverse effects recently reported in this indication.


BACKGROUND
A literature review from 1997 to 2001 has been conducted. Seventy-six articles reporting 250 cases have been found. Data analysis indicated that minocycline is the most widely incriminated molecule. Seventy-two cases revealed autoimmune disorders : lupus like syndrome associated or not with autoimmune hepatitis, 5 cases developed vasculitis. These reactions occurred in long term treatment (several weeks to several months). Fifteen cases of hypersensitivity syndromes and 3 cases of serum sickness like illness have been reported. These reactions occurred within the first weeks of exposure. Twenty-four cases of pseudotumor cerebri and 123 cases of abnormal pigmentations (skin, nails, mouth, bones or organs) have also been found. Eight cases presented other diseases.


CONCLUSIONS
Adverse effects of cyclines might be serious and sometimes unknown. Long term treatment by tetracyclines must be researched in patients presenting such symptoms. Moreover, several adverse drug reactions might be avoided by an optimal use of the drug (oesophageal ulcerations, photosensitivity) or by shorter periods of treatment (autoimmune disorders, pigmentations); only DRESS are drug adverse reactions unpredictable and sometimes severe.
Grasset
L
L
Centre régional de pharmacovigilance, hôpital de Bellevue, 42055 Saint-Etienne cedex 2, France.
Guy
C
C
Ollagnier
M
M
D000152:Acne Vulgaris / Q000188:drug therapy*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001327:Autoimmune Diseases / Q000139:chemically induced; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000209:etiology; D004802:Eosinophilia / Q000139:chemically induced; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced; D010787:Photosensitivity Disorders / Q000139:chemically induced; D011559:Pseudotumor Cerebri / Q000139:chemically induced; D012713:Serum Sickness / Q000139:chemically induced; D012880:Skin Pigmentation / Q000187:drug effects; D013754:Tetracyclines; D013997:Time Factors; D014657:Vasculitis / Q000139:chemically induced
D000900:Anti-Bacterial Agents; D013754:Tetracyclines