title: The present view of the mechanism of protein folding.
abstract: We can track the positions and movements of all the atoms in small proteins as they fold and unfold by combining experimental studies with atomic-resolution molecular dynamics simulations. General principles as to how such complex architectures form so rapidly are now emerging from in-depth studies of a few proteins.
authors.affiliation: Department of Medicinal Chemistry, Box 357610, University of Washington, Seattle, Washington 98195-7610, USA. daggett@u.washington.edu
authors.forename: Valerie
authors.initials: V
authors.lastname: Daggett
authors.forename: Alan
authors.initials: A
authors.lastname: Fersht
mesh_terms: D001426:Bacterial Proteins; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry; D010940:Plant Proteins; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry; D012260:Ribonucleases / Q000737:chemistry; D013696:Temperature; D013816:Thermodynamics
chemical_list: D001426:Bacterial Proteins; D010455:Peptides; D010940:Plant Proteins; D011506:Proteins; C093336:chymotrypsin inhibitor 2; D012260:Ribonucleases; C019760:Bacillus amyloliquefaciens ribonuclease