title: Chemokine receptor CCR2 is not essential for the development of experimental cerebral malaria.
abstract: Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8(+) T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptor expressed on CD8(+) T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-type mice were, and CD8(+) T-cell migration to the brain was not abolished.
authors.affiliation: Département d'Immunologie, Institut Cochin, INSERM U567, CNRS UMR 8104, Université René Descartes, Hôpital Cochin, Paris, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Belnoue
authors.forename: Fabio T M
authors.initials: FT
authors.lastname: Costa
authors.forename: Ana M
authors.initials: AM
authors.lastname: Vigário
authors.forename: Tatiana
authors.initials: T
authors.lastname: Voza
authors.forename: Françoise
authors.initials: F
authors.lastname: Gonnet
authors.forename: Irène
authors.initials: I
authors.lastname: Landau
authors.forename: Nico
authors.initials: N
authors.lastname: Van Rooijen
authors.forename: Matthias
authors.initials: M
authors.lastname: Mack
authors.forename: William A
authors.initials: WA
authors.lastname: Kuziel
authors.forename: Laurent
authors.initials: L
authors.lastname: Rénia
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology; D016779:Malaria, Cerebral / Q000209:etiology* / Q000473:pathology; D008636:Mesencephalon / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D054390:Receptors, CCR2; D019713:Receptors, CCR5 / Q000502:physiology; D019707:Receptors, Chemokine / Q000502:physiology*
chemical_list: C515335:Ccr2 protein, mouse; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019707:Receptors, Chemokine