title: Prevention of type 2 diabetes.
abstract: Diabetes is a major public health problem that is approaching epidemic proportions in our society and worldwide. Cardiovascular disease is the major cause of morbidity and mortality in people with diabetes. Control of cardiovascular disease risk factors is achieved only in a minority of patients. Given the magnitude of the problem and the seriousness of diabetes complications, prevention appears to be a logical approach to curb the rising prevalence of the disease. Interventions such as lifestyle modifications and the use of metformin and acarbose have been shown in randomized prospective trials to prevent diabetes in high-risk patients. Other interventions are currently being examined in large prospective studies. It is likely that one or a combination of these approaches will make diabetes prevention a reality in the near future.
authors.affiliation: Division of Endocrinology, Diabetes and Hypertension, SUNY-Downstate Health Science Center at Brooklyn/Kings County Hospital Center, 450 Clarkson Avenue, Box 50, Brooklyn, NY 11203, USA. smcfarlane@downstate.edu
authors.forename: Samy I
authors.initials: SI
authors.lastname: McFarlane
authors.forename: John J
authors.initials: JJ
authors.lastname: Shin
authors.forename: Tanja
authors.initials: T
authors.lastname: Rundek
authors.forename: J Thomas
authors.initials: JT
authors.lastname: Bigger
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology / Q000517:prevention & control* / Q000523:psychology; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000517:prevention & control*; D003927:Diet, Diabetic; D015444:Exercise; D005951:Glucose Tolerance Test; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D015994:Incidence; D008019:Life Style
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D007004:Hypoglycemic Agents