[Prevalence of vertebral fractures and aortic calcifications in hemodialysis patients: comparison with a population of the same age and sex].
Dialysis patients have bone metabolic disorders and a higher prevalence of fractures, principally peripheral fractures. However, there are few studies focusing on the prevalence of vertebral fractures. Moreover, aortic calcifications are very common and are an independent predictive factor of vascular morbidity and mortality. The objective of this study was to assess the prevalence of vertebral fractures and vascular calcifications in haemodialysis (HD) patients (n = 99), in comparison with a random sample of general population of similar age and from the same geographical area (n = 624) and study their relationship with clinical, biochemical and therapeutical data. The prevalence of vertebral fractures in HD patients and general population was 19.1% and 24.1% respectively (non-significant statistical differences). In both, sexes, the presence of vertebral fractures was positively associated with age, mean maximum Ca, mean maximum CaxP. In women, time in HD was positively associated as well. On the other hand, the prevalence of aortic calcifications was much higher in HD patients (77.9% vs 37.5%, p < 0.001). HD was a risk factor for aortic calcification in women [OR = 7.7 (IC 95% = 2.6-22.9)] as in men [OR = 5 (IC 95% = 1.9-12.9)]. Severe vascular calcifications were more frequent in HD patients, it reached 57.4% compared with 17% of general population (p < 0.001). Both, in women (64.5% vs 13.3% p < 0.001) and in men (51.4% vs 20.9%), respectively (p < 0.001). In conclusion, the prevalence of vertebral fractures was similar in HD patients and in general population. Nevertheless, frequency and severity of aortic calcifications was higher in HD patients.
Rodríguez García
M
M
Servicio de Metabolismo Oseo y Mineral, Instituto Reina Sofía, de Investigación, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo.
Gómez Alonso
C
C
Naves Díaz
M
M
Díaz López
J B
JB
Megido
J
J
Gago
E
E
Forascepi
R
R
Cannata Andía
J B
JB
D000368:Aged; D000369:Aged, 80 and over; D001018:Aortic Diseases / Q000453:epidemiology* / Q000209:etiology; D002114:Calcinosis / Q000453:epidemiology* / Q000209:etiology; D002118:Calcium / Q000097:blood; D015897:Comorbidity; D005260:Female; D005598:Fractures, Spontaneous / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010758:Phosphorus / Q000097:blood; D015995:Prevalence; D011897:Random Allocation; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D012494:Sampling Studies; D013030:Spain / Q000453:epidemiology; D016103:Spinal Fractures / Q000453:epidemiology* / Q000209:etiology
D008055:Lipids; D010758:Phosphorus; D002118:Calcium