title: Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men.
abstract: We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-I and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.
authors.affiliation: Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, UK. D.J.Gunnel@bristol.ac.uk
authors.forename: D
authors.initials: D
authors.lastname: Gunnell
authors.forename: S E
authors.initials: SE
authors.lastname: Oliver
authors.forename: T J
authors.initials: TJ
authors.lastname: Peters
authors.forename: J L
authors.initials: JL
authors.lastname: Donovan
authors.forename: R
authors.initials: R
authors.lastname: Persad
authors.forename: M
authors.initials: M
authors.lastname: Maynard
authors.forename: D
authors.initials: D
authors.lastname: Gillatt
authors.forename: A
authors.initials: A
authors.lastname: Pearce
authors.forename: F C
authors.initials: FC
authors.lastname: Hamdy
authors.forename: D E
authors.initials: DE
authors.lastname: Neal
authors.forename: J M P
authors.initials: JM
authors.lastname: Holly
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004032:Diet; D005247:Feeding Behavior; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000097:blood / Q000453:epidemiology*; D012307:Risk Factors
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I