Prevalence and prognostic significance of sMUC-1 levels in plasma cell dyscrasias.
High serum Mucin-1 (sMUC-1) levels have been shown in patients with adenocarcinoma and multiple myeloma (MM). We evaluated sMUC-1 levels in 76 patients with MM, 6 with plasma cells leukaemia (PCL) and 89 with monoclonal gammopathy of undetermined significance, to establish prevalence data and verify its possible prognostic role. Of the 171 patients, 27 [16%; 95% confidence interval (CI): 10-21%] had high sMUC-1 levels compared with healthy subjects (1.5%; 95% CI: 0-4%). Elevated sMUC-1 levels in MM and PCL patients correlated with anaemia and elevated serum lactate dehydrogenase levels; these patients showed a shorter survival than those with normal sMUC-1 levels (median overall survival: 25 vs. 49 months, P = 0.003).
Luminari
Stefano
S
Dipartimento di Oncologia ed Ematologia, Università di Modena e Reggio Emilia, Milan, Italy. luminari@unimore.it
Goldaniga
Maria
M
Ceccherelli
Fulvia
F
Guffanti
Andrea
A
Bombardieri
Emilio
E
Marcheselli
Raffaella
R
Cro
Lilla
L
Colombi
Mariangela
M
Federico
Massimo
M
Baldini
Luca
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism*; D010265:Paraproteinemias / Q000097:blood* / Q000401:mortality; D011379:Prognosis; D016019:Survival Analysis
D018396:Mucin-1