title: Microbial hydroxylation of progesterone with Acremonium strictum.
abstract: Microbial hydroxylation of progesterone occurred in the culture of Acremonium strictum PTCC 5282 to produce two hydroxylated pregnene-like steroids. The metabolites were purified and characterized using spectroscopic methods and identified as 15alpha-hydroxyprogesterone and 15alpha-hydroxydeoxycorticosterone.
authors.affiliation: Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, 14174, Tehran, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Faramarzi
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Tabatabaei Yazdi
authors.forename: Mohsen
authors.initials: M
authors.lastname: Amini
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Zarrini
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000164:Acremonium / Q000378:metabolism*; D001711:Biotransformation; D006889:Hydroxycorticosteroids / Q000737:chemistry / Q000378:metabolism; D006900:Hydroxylation; D006908:Hydroxyprogesterones / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D011374:Progesterone / Q000737:chemistry / Q000378:metabolism*
chemical_list: D006889:Hydroxycorticosteroids; D006908:Hydroxyprogesterones; D011374:Progesterone