title: Dietary mono- and polyunsaturated fatty acids similarly increase plasma apolipoprotein A-IV concentrations in healthy men and women.
abstract: We investigated the effect of dietary fatty acid composition on plasma apolipoprotein (apo) A-IV concentrations. Plasma apo A-IV concentrations were measured by ELISA in plasma of 48 healthy men and women in a controlled dietary study. First, all participants consumed a 2-wk baseline diet rich in saturated fatty acids (SFA). Then, they were randomly assigned to one of three dietary treatments, which contained refined olive oil [rich in monounsaturated fatty acids (MUFA), n = 17], rapeseed oil [rich in MUFA and alpha-linolenic acid [18:3(n-3)], n = 13], or sunflower oil [rich in (n-6) PUFA, n = 18] as the principal source of fat for 4 wk. The plasma concentrations of apo A-IV increased when subjects consumed the diets rich in unsaturated fatty acids, by 16% or 13.0 mg/L [F((2,76)) = 12.874, P < 0.001 by repeated-measures ANOVA]. The increase was not affected by diet group affiliation, gender or apo A-IV genotype. In conclusion, diets rich in unsaturated fatty acids, independent of the degree of unsaturation, gender and apo A-IV genotype, increase plasma apo A-IV concentrations compared with a baseline diet rich in SFA in healthy men and women.
authors.affiliation: Institute of Arteriosclerosis Research at the University of Münster, 48149 Münster, Germany. mkratz@uni-muenster.de
authors.forename: Mario
authors.initials: M
authors.lastname: Kratz
authors.forename: Ursel
authors.initials: U
authors.lastname: Wahrburg
authors.forename: Arnold
authors.initials: A
authors.lastname: von Eckardstein
authors.forename: Benjie
authors.initials: B
authors.lastname: Ezeh
authors.forename: Gerd
authors.initials: G
authors.lastname: Assmann
authors.forename: Florian
authors.initials: F
authors.lastname: Kronenberg
mesh_terms: D000328:Adult; D001054:Apolipoproteins A / Q000097:blood*; D004032:Diet; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D012016:Reference Values
chemical_list: D001054:Apolipoproteins A; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; C022205:apolipoprotein A-IV