[Intravenous contrast imaging in diagnosis of acute renal allograft rejection: a comparative study with color flow Doppler imaging].
OBJECTIVE
To assess the value of intermittent contrast second harmonic imaging (SHI) incorporating acoustic densitometry in the diagnosis of acute renal allograft rejection in comparison with color Doppler flow imaging (CDFI) for determining the resistance index (RI).


METHODS
Eight canine models of acute renal allograft rejection were established, subjected subsequently to examinations with SHI and acoustic densitometry to determine the acoustic density. Color flow Doppler was also performed to determine RI, and serum creatinine (Cr) levels were measured.


RESULTS
The time-intensity curve (TIC) showed that the area under the curve, the peak intensity (PI) and RI all had linear correlation with serum Cr levels, with the correlation coefficient gamma of 0.978, 0.972 and 0.708 respectively (by SPSS10.0).


CONCLUSIONS
Intermittent contrast SHI is effective to evaluate the perfusion of renal allograft, and when combined with acoustic densitometry, the resultant TIC parameters are in closer correlation with acute renal allograft rejection than RI.
Li
Zhuo
Z
Department of Ultrasound, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. lizhuo-lee@163.com
Gong
Wei-bin
WB
Liu
Hong-mei
HM
Cui
Zhong-lin
ZL
Huang
Hong-bo
HB
Sun
Xu-yong
XY
D000208:Acute Disease; D000818:Animals; D003404:Creatinine / Q000097:blood; D003720:Densitometry; D004285:Dogs; D005260:Female; D006084:Graft Rejection / Q000000981:diagnostic imaging*; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D012079:Renal Circulation; D014184:Transplantation, Homologous; D018615:Ultrasonography, Doppler, Color
D003404:Creatinine