title: Successful treatment of partial nephrogenic diabetes insipidus with thiazide and desmopressin.
abstract: OBJECTIVE
  To clarify whether combination treatment with desmopressin (DDAVP) and thiazide was clinically effective in a patient with congenital nephrogenic diabetes insipidus (CNDI), we evaluated the treatment in a 7-year-old boy with CNDI who had demonstrated a partial response to DDAVP.
  
  
  METHODS
  Both volume of urine and the presence of nocturia were determined during treatment.
  
  
  RESULTS
  Neither the usual therapy of a low-salt diet and a thiazide nor intranasal therapy with a large dose of DDAVP was effective. However, combination treatment resulted in a decrease in urinary volume and the disappearance of nocturia.
  
  
  CONCLUSIONS
  DDAVP coupled with thiazide may be useful for CNDI in patients who have shown a partial response to DDAVP.
authors.affiliation: Department of Pediatrics, Neonatology and Congenital Disorders, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan. hamizuno@med.nagoya-cu.ac.jp
authors.forename: Haruo
authors.initials: H
authors.lastname: Mizuno
authors.forename: Shinji
authors.initials: S
authors.lastname: Fujimoto
authors.forename: Yukari
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: Masanori
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Ohro
authors.forename: Shinichi
authors.initials: S
authors.lastname: Uchida
authors.forename: Sei
authors.initials: S
authors.lastname: Sasaki
authors.forename: Hajime
authors.initials: H
authors.lastname: Togari
mesh_terms: D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D018500:Diabetes Insipidus, Nephrogenic / Q000150:complications / Q000188:drug therapy*; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D008297:Male; D012076:Renal Agents / Q000627:therapeutic use*; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome; D014237:Trichlormethiazide / Q000627:therapeutic use*; D014555:Urination Disorders / Q000188:drug therapy / Q000209:etiology
chemical_list: D004232:Diuretics; D012076:Renal Agents; D049993:Sodium Chloride Symporter Inhibitors; D003894:Deamino Arginine Vasopressin; D014237:Trichlormethiazide