Elevated osteopontin levels in active relapsing-remitting multiple sclerosis.
In the search for proteins that might play a role in the pathogenesis of multiple sclerosis (MS), osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene expressed within MS lesions. Here, we report significantly increased OPN protein levels in plasma of relapsing-remitting MS patients. In contrast, OPN protein levels in primary progressive and secondary progressive MS patients were similar to healthy control levels. Interestingly, active relapsing-remitting patients had higher OPN protein levels than patients without relapses.
Vogt
Mario H J
MH
Division of Immunological and Infectious Diseases, TNO Prevention and Health, Leiden, The Netherlands. mhj.vogt@pg.tno.nl
Lopatinskaya
Luba
L
Smits
Monique
M
Polman
Chris H
CH
Nagelkerken
Lex
L
D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000378:metabolism*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000378:metabolism*; D053495:Osteopontin; D012795:Sialoglycoproteins / Q000097:blood / Q000378:metabolism*
C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D053495:Osteopontin