Lipid metabolism in Plasmodium falciparum-infected erythrocytes: possible new targets for malaria chemotherapy.
The emergence and spread of drug-resistant parasites coupled with the absence of an effective vaccine makes malaria treatment more complicated, and thus the development of new antimalarial drugs is one of the urgent tasks in malaria research. This review highlights lipid metabolism in Plasmodium parasite cells, the study of which would lead to providing new targets for therapeutic intervention.
Mitamura
Toshihide
T
Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan. mitamura@biken.osaka-u.ac.jp
Palacpac
Nirianne Marie Q
NM
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology* / Q000627:therapeutic use; D004351:Drug Resistance; D004912:Erythrocytes / Q000469:parasitology*; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000096:biosynthesis; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D010963:Plasmodium falciparum / Q000378:metabolism*
D000962:Antimalarials; D008055:Lipids