Possible increased risk for Alzheimer's disease associated with neprilysin gene.
Neprilysin has recently been reported to be the major physiological Abeta-degradating enzyme. In this study we describe a new biallelic polymorphism in the 3'UTR of the neprilysin gene in a representative population sample. The (*)159C/C genotype was found to be associated with an increased risk for Alzheimer's disease in an age-dependent manner. Adjusting for sex and APOE status, an odds ratio of 2.74 (p < 0.05) was observed among patients under 75 years old.
Clarimón
J
J
Unitat de Biologia Evolutiva, Universitat Pompeu Fabra, Barcelona, Spain.
Muñoz
F J
FJ
Boada
M
M
Tàrraga
L
L
Sunyer
J
J
Bertranpetit
J
J
Comas
D
D
D020413:3' Untranslated Regions / Q000235:genetics; D000367:Age Factors; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000201:enzymology / Q000235:genetics* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001921:Brain / Q000201:enzymology* / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D015260:Neprilysin / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics
D020413:3' Untranslated Regions; D016229:Amyloid beta-Peptides; D015260:Neprilysin