Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections.
Pantothenate kinase (CoaA) catalyzes the first step of the coenzyme A biosynthetic pathway. Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the enzyme. We have also identified a series of low-molecular-weight compounds which are effective inhibitors of S. aureus CoaA.
Choudhry
Anthony E
AE
Microbial, Musculoskeletal and Proliferative Diseases and Bioinformatics, GlaxoSmithKline Pharmaceuticals, Collegeville Pennsylvania 19426, USA.
Mandichak
Tracy L
TL
Broskey
John P
JP
Egolf
Richard W
RW
Kinsland
Cynthia
C
Begley
Tadhg P
TP
Seefeld
Mark A
MA
Ku
Thomas W
TW
Brown
James R
JR
Zalacain
Magdalena
M
Ratnam
Kapila
K
D000255:Adenosine Triphosphate / Q000378:metabolism; D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D003065:Coenzyme A / Q000096:biosynthesis; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010205:Pantothenic Acid / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors* / Q000235:genetics; D010802:Phylogeny; D016415:Sequence Alignment; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000201:enzymology* / Q000235:genetics; D014407:Tumor Cells, Cultured
D004269:DNA, Bacterial; D004791:Enzyme Inhibitors; D010205:Pantothenic Acid; D000255:Adenosine Triphosphate; D017853:Phosphotransferases (Alcohol Group Acceptor); C023088:pantothenate kinase; D003065:Coenzyme A