Sporadic Creutzfeldt-Jakob disease mimicking variant Creutzfeldt-Jakob disease.
BACKGROUND
The determination of the form of prion disease and early diagnosis are important for prognostic, public health, and epidemiologic reasons.


OBJECTIVE
To describe a patient with sporadic Creutzfeldt-Jakob disease (sCJD) who had a clinical history and initial electroencephalogram and magnetic resonance imaging findings consistent with variant CJD (vCJD).


RESULTS
Results of a repeated electroencephalogram were suggestive of sCJD, and a subsequent brain biopsy confirmed this diagnosis.


CONCLUSIONS
This case cautions against relying solely on T2- and diffusion-weighted pulvinar hyperintensity and clinical features to differentiate between vCJD and sCJD, and further supports established diagnostic criteria for vCJD.
Martindale
Jennifer
J
Department of Neurology, University of California-San Francisco, 94143, USA. mgeschwind@memory.ucsf.edu
Geschwind
Michael D
MD
De Armond
Stephen
S
Young
Geoffrey
G
Dillon
W P
WP
Henry
Roland
R
Uyehara-Lock
Jane H
JH
Gaskin
David A
DA
Miller
Bruce L
BL
D000328:Adult; D001706:Biopsy; D001921:Brain / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000145:classification / Q000473:pathology*; D003937:Diagnosis, Differential; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D020649:Pulvinar / Q000473:pathology