title: Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences.
abstract: This review attempts to illuminate the glycolipid antigen presentation properties of CD1d, how CD1d controls the function of natural T (iNKT) cells and how CD1d and iNKT cells interact to jump-start the immune system. It is postulated that the CD1d-iNKT cell system functions as a sensor, sensing alterations in cellular lipid content by virtue of its affinity for such ligands. The presentation of a neo-self glycolipid, presumably by infectious assault of antigen-presenting cells, activates iNKT cells, which promptly release pro-inflammatory and anti-inflammatory cytokines and jump-start the immune system.
authors.affiliation: Department of Microbiology and Immunology, Vanderbilt University School of Medical School, Nashville, TN 37232, USA.
authors.forename: Aleksandar K
authors.initials: AK
authors.lastname: Stanic
authors.forename: Jang-June
authors.initials: JJ
authors.lastname: Park
authors.forename: Sebastian
authors.initials: S
authors.lastname: Joyce
mesh_terms: D017951:Antigen Presentation / Q000276:immunology; D018949:Antigens, CD1 / Q000276:immunology*; D055610:Antigens, CD1d; D002454:Cell Differentiation / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology*; D018448:Models, Immunological; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D018949:Antigens, CD1; D055610:Antigens, CD1d; C526877:CD1D protein, human; D016207:Cytokines