title: New aspects of integrin-mediated leukocyte adhesion in inflammation: regulation by haemostatic factors and bacterial products.
abstract: Leukocyte recruitment to sites of inflammation, infection or vascular injury is a complex event, depending on a tightly coordinated sequence of leukocyte-endothelial- and leukocyte-platelet interactions, which are controlled by the expression and activation of various adhesion receptors and protease systems. The present review will focus on novel aspects of the regulation of integrin-dependent leukocyte adhesion by haemostatic factors and bacterial products. In particular, after a short overview of leukocyte recruitment, the review (i) will focus on the crosstalk between haemostatic factors and adhesion molecules with respect to leukocyte extravasation based on the paradigms of the urokinase receptor and high molecular weight kininogen, (ii) will provide information on novel mechanisms for the regulation of leukocyte recruitment by bacterial proteins, on the basis of the anti-inflammatory role of Staphylococcus aureus extracellular adhesive protein and (iii) will draw attention to the junctional adhesion molecules, a novel family of adhesive receptors that are counter-receptors for leukocyte integrins and mediate vascular cell interactions. The better understanding of the interactions between vascular cells and particularly of integrin-dependent leukocyte adhesion may lead to the development of novel therapeutical concepts in inflammatory vascular disorders.
authors.affiliation: Institute for Biochemistry, Medical Faculty, Justus-Liebig-University, Giessen, Germany.
authors.forename: Joong-Sup
authors.initials: JS
authors.lastname: Rhee
authors.forename: Sentot
authors.initials: S
authors.lastname: Santoso
authors.forename: Mathias
authors.initials: M
authors.lastname: Herrmann
authors.forename: Angelika
authors.initials: A
authors.lastname: Bierhaus
authors.forename: Sandip M
authors.initials: SM
authors.lastname: Kanse
authors.forename: Andreas E
authors.initials: AE
authors.lastname: May
authors.forename: Peter P
authors.initials: PP
authors.lastname: Nawroth
authors.forename: Robert W
authors.initials: RW
authors.lastname: Colman
authors.forename: Klaus T
authors.initials: KT
authors.lastname: Preissner
authors.forename: Triantafyllos
authors.initials: T
authors.lastname: Chavakis
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D002448:Cell Adhesion; D004730:Endothelium, Vascular / Q000378:metabolism; D006487:Hemostasis; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D016023:Integrins / Q000378:metabolism*; D007704:Kininogens / Q000378:metabolism; D007962:Leukocytes / Q000166:cytology*; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism; D055293:Receptors, Urokinase Plasminogen Activator; D013211:Staphylococcus aureus / Q000378:metabolism
chemical_list: D016023:Integrins; D007704:Kininogens; C524898:PLAUR protein, human; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator