[Measurement of nerve growth factor in the nasal mucosa of experimental allergic rhinitis].
OBJECTIVE
To investigate the role of nerve growth factor in the development of allergic rhinitis.


METHODS
Animal model of allergic rhinitis was established in rat, the content of nerve growth factor in the nasal mucosa was measured using enzyme-linked immunosorbent assay (ELISA) technique.


RESULTS
The content of nerve growth factor significantly (P < 0.001) increased in the nasal mucosa of experimental allergic rhinitis (6.65 +/- 0.42) ng/g wet weight, compared with that in control animals (3.51 +/- 0.29) ng/g wet weight.


CONCLUSIONS
Nerve growth factor may play an important role in the development of allergic rhinitis by regulating expression and release of neuropeptides and/or by activating immune cells such as mast cells.
Zhao
S
S
Department of Otorhinolaryngology, Xiangya Hospital, Central South University, Changsha 410008, China. zgebld95@public.cs.hn.cn
Zhou
X
X
D000818:Animals; D005260:Female; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D009297:Nasal Mucosa / Q000378:metabolism* / Q000473:pathology; D009414:Nerve Growth Factors / Q000032:analysis*; D009479:Neuropeptides / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism* / Q000473:pathology
D009414:Nerve Growth Factors; D009479:Neuropeptides