title: Testing different storage conditions for (99m)Tc-MAG3 kit: can hot fractioning reduce the cost per unit dose?
abstract: Since its release for routine clinical use, (99m)Tc-mercaptoacetyltriglycine (MAG3) has become an important alternative to (131)I-labeled orthoiodohippuran. The cold kit for MAG3 is expensive, especially in developing countries. Therefore, unique storage conditions should be provided for cost reduction. Cold fractioning is a well-known procedure but has special requirements, such as a nitrogen tank and a laminar flow hood. The aim of this study was to prolong the shelf life of (99m)Tc-labeled MAG3 by a hot fractioning method, which separates the patient doses after (99m)Tc labeling. The radiochemical purity of the (99m)Tc-labeled MAG3 kit was tested under different storage conditions. Hot fractioning of the (99m)Tc-labeled MAG3 kit was found to be a possible alternative to cold fractioning for routine clinical studies.
authors.affiliation: Department of Nuclear Medicine, Hacettepe University Medical Center, Ankara, Turkey. pkirati@hacettepe.edu.tr
authors.forename: Pinar Ozgen
authors.initials: PO
authors.lastname: Kiratli
authors.forename: Bilge Volkan
authors.initials: BV
authors.lastname: Salanci
mesh_terms: D003365:Costs and Cost Analysis / Q000379:methods; D004355:Drug Stability; D004356:Drug Storage / Q000379:methods*; D005240:Feasibility Studies; D006358:Hot Temperature; D007553:Isotope Labeling / Q000379:methods*; D011933:Reagent Kits, Diagnostic; D017263:Technetium Tc 99m Mertiatide / Q000138:chemical synthesis / Q000737:chemistry* / Q000191:economics
chemical_list: D011933:Reagent Kits, Diagnostic; D017263:Technetium Tc 99m Mertiatide