title: [Experimental studies of hypoglycemic action on total flavone of Ampelopsis grossedentata from Guangxi].
abstract: OBJECTIVE
  To study hypoglycemic action of total flavone (GXTF) of Ampelopsis grossedentata from Guangxi by observing the effects of GXTF on blood glucose levels in many strain animal models.
  
  
  METHODS
  The blood glucose levels in many strain animal models were determined after oral administration, with the models of diabetes induced by alloxan, of hyperglycemic mice induced by epinephrine and glucose, and normal mice.
  
  
  RESULTS
  GXTF had better therapeutical action on diabetes mice induced by alloxan, and could significantly lowered the blood glucose levels of hyperglycemic mice induced by epinephrine and glucose, but had no significant effects on blood glucose levels of normal mice. Acute toxicity test showed that the maximum oral dosage is 26.0 g.kg-1.
  
  
  CONCLUSIONS
  GXTF has better hypoglycemic effect on many strain animal models and toxicity is vary small.
authors.affiliation: Guangxi Institute of Traditional Medical and Pharma-ceutical Sciences, Nanning 530022, Guangxi, China. zhongzhengxian@163.net
authors.forename: Zheng-xian
authors.initials: ZX
authors.lastname: Zhong
authors.forename: Jie-pin
authors.initials: JP
authors.lastname: Qin
authors.forename: Gui-fen
authors.initials: GF
authors.lastname: Zhou
authors.forename: Xue-fen
authors.initials: XF
authors.lastname: Chen
mesh_terms: D032421:Ampelopsis / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002681:China; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004837:Epinephrine / Q000037:antagonists & inhibitors; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D005947:Glucose / Q000037:antagonists & inhibitors; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D007004:Hypoglycemic Agents; D005947:Glucose; D004837:Epinephrine