[Effect of dan-shen, san-qi of different proportion on platelet aggregation and adhesion in normal rabbits].
OBJECTIVE
To observe the effect of the crude extracts of Dan-shen root and San-qi of different proportion on platelet aggregation and adhesion in normal rabbits.


METHODS
With rabbits, ig. (4d, exsanguinated via carotid artery, percentage of platelet aggregation and adhesion was measured.


CONCLUSIONS
Aspirin (4.4 mg/Kg) could markedly inhibit platelet aggregation and adhesion in normal rabbit. The proportions of Dan-shen root/San-qi (10:0, 10:1, 10:3, 10:6, 1:10) could markedly inhibit platelet aggregation, among which 10:3 was the best. San-qi alone had little effect on aggregation. The proportions of Dan-shen root/San-qi (10:3, 10:6, 0:10) could markedly inhibit platelet adhesion, among which 0:10 was the best, and the proportions(10:0, 10:1, 1:10) had little effect.
Liu
Ting
T
Institute of Chinese Materia Medica, China Academy of TCM, Beijing 100700, China.
Qin
Cai-ling
CL
Zhang
Yi
Y
Kang
Li-yuan
LY
Sun
You-fu
YF
Zhang
Bo-li
BL
D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D008297:Male; D005894:Panax / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D027561:Salvia miltiorrhiza / Q000737:chemistry
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors