title: Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine.
abstract: Combining the first generation H(1) antihistamine chlorpheniramine (1) with H(3) ligands of the alkylamine type has led to the identification of compound 9d, a dual ligand of both the H(1) and H(3) receptors.
authors.affiliation: The Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. robert.aslanian@spcorp.com
authors.forename: Robert
authors.initials: R
authors.lastname: Aslanian
authors.forename: Mwangi wa
authors.initials: Mw
authors.lastname: Mutahi
authors.forename: Neng-Yang
authors.initials: NY
authors.lastname: Shih
authors.forename: John J
authors.initials: JJ
authors.lastname: Piwinski
authors.forename: Robert
authors.initials: R
authors.lastname: West
authors.forename: Shirley M
authors.initials: SM
authors.lastname: Williams
authors.forename: Susan
authors.initials: S
authors.lastname: She
authors.forename: Ren-Long
authors.initials: RL
authors.lastname: Wu
authors.forename: John A
authors.initials: JA
authors.lastname: Hey
mesh_terms: D000818:Animals; D002744:Chlorpheniramine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008024:Ligands; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D018100:Receptors, Histamine H3 / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D006633:Histamine Antagonists; D006634:Histamine H1 Antagonists; D008024:Ligands; D011969:Receptors, Histamine H1; D018100:Receptors, Histamine H3; D002744:Chlorpheniramine