title: Polar expeditions--provisioning the centrosome for mitosis.
abstract: It is now clear that both centrioles and their surrounding pericentriolar material (PCM) are capable of self-assembly. Whereas centrioles are normally duplicated during G1-S phase, PCM components may be loaded onto centrosomes in both a microtubule-dependent and -independent manner at all stages of the cell cycle. Centrosomes enlarge dramatically after mitotic entry, when both Aurora A and Polo-like kinases cooperate to recruit additional gamma-tubulin ring complexes and microtubule-associated proteins to assist spindle formation.
authors.affiliation: Cancer Research UK Cell Cycle Genetics Research Group, University of Cambridge, Department of Genetics, Downing Street, Cambridge, CB2 3EH, UK.
authors.forename: Sarah P
authors.initials: SP
authors.lastname: Blagden
authors.forename: David M
authors.initials: DM
authors.lastname: Glover
mesh_terms: D000818:Animals; D064127:Aurora Kinases; D002502:Centrioles / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure; D018385:Centrosome / Q000201:enzymology / Q000502:physiology*; D029721:Drosophila Proteins; D004398:Dyneins / Q000378:metabolism; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D008938:Mitosis; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D014404:Tubulin / Q000502:physiology
chemical_list: D029721:Drosophila Proteins; D008869:Microtubule-Associated Proteins; D014404:Tubulin; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases; D004398:Dyneins