[The association of HLA-DRB1 allele polymorphism with the genetic susceptibility to liver cirrhosis due to hepatitis B virus].
OBJECTIVE
To assess the association of human leucocyte antigen (HLA)-DRB1 allele with the genetic susceptibility to cirrhosis due to hepatitis B virus(HBV).


METHODS
One hundred and six patients with cirrhosis due to HBV in Hubei area were investigated for HLA-DRB1 gene by polymerase chain reaction-sequence specific primers technique. The results were compared with those from 108 normal healthy people.


RESULTS
The frequency of HLA-DRB1*1201/1202 allele was 20.28% in patient group, which was significantly higher than the frequency (6.01%) in control group, the relative risk (RR) being 4.9878 (P<0.01). The frequency of HLA-DRB1*1501/1502 allele was decreased in patient group (patient 6.6%, control 16.67%, RR=0.3043, P<0.05), while the frequencies of other HLA-DRB1 alleles were not significantly different(P>0.05).


CONCLUSIONS
HLA-DRB1*1201/1202 allele may be the susceptibility gene in patients with cirrhosis due to HBV in Hubei Han nationality; HLA-DRB1*1501/1502 allele is a resistant gene in patients with cirrhosis.
Cheng
Yuan-qiao
YQ
Institute of the Liver Diseases, Tongji Medical College, University of Huazhong Science and Technology, Wuhan, Hubei, 430030 PR China.
Lin
Ju-sheng
JS
Huang
Li-hong
LH
Tian
De-ying
DY
Xiong
Ping
P
D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006509:Hepatitis B / Q000150:complications / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics / Q000472:pathogenicity*; D019694:Hepatitis B, Chronic / Q000150:complications / Q000235:genetics; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains