Cancer and the FRA3B/FHIT fragile locus: it's a HIT.
The FHIT gene encompassing the most active common human chromosomal fragile region, FRA3B, was discovered in 1996 and proposed as a tumour suppressor gene for important human cancers. Seven years and more than 350 reports later, early questions concerning its tumour suppressor role have been answered. Recent studies on the role of Fhit loss in major types of human cancers report association with high proliferative and low apoptotic indices, node positivity, loss of mismatch repair protein, likelihood of progression and reduced survival.
Huebner
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Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, PA 19107, USA. Kay.Huebner@mail.tju.edu
Croce
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D017766:Acid Anhydride Hydrolases; D017209:Apoptosis; D020137:Base Pair Mismatch; D002455:Cell Division; D018450:Disease Progression; D016147:Genes, Tumor Suppressor; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics* / Q000494:pharmacology; D009369:Neoplasms / Q000235:genetics* / Q000503:physiopathology; D013534:Survival; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase