title: Relation between cerebral blood flow and metabolism explained by a model of oxygen exchange.
abstract: The cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRo(2)) are major determinants of the contrast in functional magnetic resonance imaging and optical imaging. However, the coupling between CBF and CMRo(2) during cerebral activation remains controversial. Whereas most of the previous models tend to show a nonlinear coupling, experimental studies have led to conflicting conclusions. A physiologic model was developed of oxygen transport through the blood-brain barrier (BBB) for dynamic and stationary states. Common model simplifications are proposed and their implications for the CBF/CMRo(2) relation are studied. The tissue oxygen pool, the BBB permeability, and the hemoglobin dissociation curve are physiologic parameters directly involved in the CBF/CMRo(2) relation. We have been shown that the hypothesis of a negligible tissue oxygen pool, which was admitted by most of the previous models, implies a tight coupling between CBF and CMRo(2). By relaxing this hypothesis, a real uncoupling was allowed that gives a more coherent view of the CBF/CMRo(2) relation, in better agreement with the hypercapnia data and with the variability reported in experimental works for the relative changes of those two variables. This also allows a temporal mismatch between CBF and CMRo(2), which influences the temporal shape of oxygenation at the capillary end.
authors.affiliation: INSERM U 483, Université Paris 6, France. Romain.Valabregue@snv.jussieu.fr
authors.forename: Romain
authors.initials: R
authors.lastname: Valabrègue
authors.forename: Agnès
authors.initials: A
authors.lastname: Aubert
authors.forename: Jacques
authors.initials: J
authors.lastname: Burger
authors.forename: Jacques
authors.initials: J
authors.lastname: Bittoun
authors.forename: Robert
authors.initials: R
authors.lastname: Costalat
mesh_terms: D001921:Brain / Q000098:blood supply* / Q000378:metabolism*; D002196:Capillaries / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D008955:Models, Cardiovascular; D010100:Oxygen / Q000378:metabolism*
chemical_list: D010100:Oxygen