title: An MEG study of P300 activity during a color discrimination task 2: source localization study.
abstract: In this study, we described developmental changes in an event-related magnetic source of P300 activity during a visual oddball paradigm using magnetoencephalography. The maximum and minimum points of each peak of target P300 activity were scattered in a more anterior temporal area in children than in adults. The single dipole source analysis successfully estimated a dipole in the vicinity of the thalamus and the cingulate gyrus in adults. The location differed in children, although the dipole had overall greater moment in children than in adults. Our findings suggest that the thalamus plays an important role in generating P300 activity specific to color discrimination processing, and that in children the source is not consistent during development.
authors.affiliation: Department of Psychiatry and Behavioral Science, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-City, Tokyo, 113-8519, Japan. horigti.psyc@tmd.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Horiguchi
authors.forename: Katsuya
authors.initials: K
authors.lastname: Ohta
authors.forename: Toru
authors.initials: T
authors.lastname: Nishikawa
mesh_terms: D000328:Adult; D000367:Age Factors; D002648:Child; D003118:Color Perception / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology*; D018913:Event-Related Potentials, P300; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D013702:Temporal Lobe / Q000502:physiology; D013788:Thalamus / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology