title: Coronary artery blood flow velocities in various fetal conditions.
abstract: OBJECTIVE
  To determine fetal coronary artery peak blood flow velocities in normal and high-risk pregnancies.
  
  
  METHODS
  Coronary artery peak systolic and diastolic blood flow velocities were measured by pulsed-wave Doppler velocimetry after identification of the coronary arteries by color Doppler imaging. Peak blood velocities obtained from normal pregnancies were related to gestational age using linear regression analysis. Blood flow velocities in normal fetuses were compared to measurements obtained in various fetal conditions.
  
  
  RESULTS
  In normal fetuses coronary artery blood flow was visualized at a median gestational age of 33 + 6 weeks; median systolic and diastolic peak blood flow velocities were 0.21 and 0.43 m/s, respectively, and showed no significant change with gestational age. In growth-restricted fetuses coronary artery blood flow was visualized significantly earlier in gestation (median 28 + 2 weeks); systolic and diastolic peak blood flow velocities were higher at 0.25 and 0.48 m/s, respectively (P < 0.05). The highest coronary blood flow velocities were observed with fetal anemia. Coronary artery blood flow was also measured in fetuses with ductus arteriosus constriction due to indomethacin. Velocities did not differ from normal fetuses. Both in fetal anemia and ductus arteriosus constriction coronary artery blood flow could no longer be visualized with resolution of the underlying condition.
  
  
  CONCLUSIONS
  Examination of coronary artery blood flow dynamics in the human fetus demonstrates acute increases in diastolic velocities in severe anemia and ductus arteriosus constriction based on the severity of the condition. In fetuses with growth restriction increased coronary blood flow velocities can be appreciated throughout the cardiac cycle. Clinical correlation in the interpretation of coronary blood flow dynamics in the human fetus is essential.
authors.affiliation: Center for Advanced Fetal Care, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland, Baltimore, MD 21201, USA. abaschat@umm.edu
authors.forename: A A
authors.initials: AA
authors.lastname: Baschat
authors.forename: M V
authors.initials: MV
authors.lastname: Muench
authors.forename: U
authors.initials: U
authors.lastname: Gembruch
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000502:physiology*; D005260:Female; D005315:Fetal Diseases / Q000503:physiopathology*; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods; D011247:Pregnancy; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal / Q000379:methods