[Effects of bu yang huan wu decoction on astrocytes after cerebral ischemia and reperfusion].
OBJECTIVE
To study the effects of Bu Yang Huan Wu Decoction on astrocytes after cerebral ischemia and reperfusion.


METHODS
Cerebral ischemia model in gerbils was produced by ligating bilateral common carotid artery. The dynamic expressin of GFAP were determined by immunochemistry after cerebyal ischemia for 15 min followed by reperfusion for 24 hours and 48 hours.


RESULTS
GFAP positive reactions reached a peak after cerebral ischemia for 15 min followed by reperfusion for 24 hours. Bu Yang Huan Wu Decoction decreased the expression. GFAP positive reactions decreased after cerebral ischemia for 15 min followed by reperfusion for 48 hours, Bu Yang Huan Wu Decoction increased the expression.


CONCLUSIONS
The regulation of Bu Yang Huan Wu Decoction on astrocytes after cerebral ischemia and reperfusion may be related to repairing process after cerebral ischemia.
Lai
Zhen
Z
Shenzhen People's Hospital, Shenzhen 518020, Guangdong, China.
Wang
Sha-yan
SY
Geng
Xiao-yin
XY
Deng
Chang-qing
CQ
Zhang
Ruan-zhang
RZ
D000818:Animals; D001253:Astrocytes / Q000187:drug effects*; D002545:Brain Ischemia / Q000150:complications; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism / Q000473:pathology*
D004365:Drugs, Chinese Herbal; D005904:Glial Fibrillary Acidic Protein; C460102:buyang huanwu