title: Expression of Heparin-Binding Epidermal Growth Factor-like Growth Factor in Pancreatic Adenocarcinoma.
abstract: Heparin-binding epidermal growth factor-likegrowth factor (HB-EGF) belongs to the EGF familyand was originally identified in the conditionedmedium of a human histiotic lymphoma cell line, U937 (1). This protein is synthesized as a preproformof 208 amino acids (2), is expressed as amembrane-anchored HB-EGF, and is released as asoluble form of 87 amino acids after being processedby protease (1,2). HB-EGF binds to the EGF receptor(EGF-R) in competition with EGF (3), and exogenoussoluble HB-EGF is known to stimulateDNA synthesis in primary rat hepatocytes in a dosedependentmanner (4).
authors.affiliation: Department of Surgery, Osaka Seamen's Insurance Hospital, 1-8-30, Chikko, Minato-ku, Osaka 552-0021, Japan; Department of Pathology, Osaka University Faculty of Medicine, 1-7, Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Shigeki
authors.initials: S
authors.lastname: Higashiyama
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takeda
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Ken-Ichi
authors.initials: KI
authors.lastname: Wakasa
authors.forename: Nariaki
authors.initials: N
authors.lastname: Matsuura