Alpha interferon augments cidofovir's antiviral and antiproliferative activities.
The antiviral and antiproliferative activities of alpha 2a interferon (IFN-alpha 2a) and cidofovir in human papillomavirus type 16 (HPV-16)-transformed keratinocytes were evaluated. The compounds in combination were more effective than comparable levels of either drug alone. Evaluation of effective drug ratios revealed a synergistic cooperation between IFN-alpha 2a and cidofovir in inhibiting the proliferation of HPV-infected cells.
Johnson
Jeffrey A
JA
Department of Microbiology and Molecular Medicine and the Greenville Hospital System Biomedical Cooperative, Clemson University, Clemson, South Carolina 29634, USA. jjohnson1@cdc.gov
Gangemi
J David
JD
D000998:Antiviral Agents / Q000494:pharmacology*; D015153:Blotting, Western; D002461:Cell Line, Transformed; D000077404:Cidofovir; D015169:Colony Count, Microbial; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000378:metabolism; D003596:Cytosine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004357:Drug Synergism; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D015603:Keratinocytes / Q000821:virology; D009856:Oncogene Proteins, Viral / Q000378:metabolism; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D027383:Papillomaviridae / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D050725:Papillomavirus E7 Proteins; D030361:Papillomavirus Infections / Q000821:virology*; D012097:Repressor Proteins; D016160:Retinoblastoma Protein / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014412:Tumor Virus Infections / Q000821:virology*
D000998:Antiviral Agents; C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; C068651:E6 protein, Human papillomavirus type 16; D016898:Interferon-alpha; D009856:Oncogene Proteins, Viral; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D050725:Papillomavirus E7 Proteins; D012097:Repressor Proteins; D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53; C059731:oncogene protein E7, Human papillomavirus type 16; D003596:Cytosine; D000077404:Cidofovir