Tumor deprivation of oxygen and tumor suppressor gene function.
Yun
Zhong
Z
Department of Radiation Oncology, Stanford University School of Medicine, CA, USA.
Giaccia
Amato J
AJ
D000818:Animals; D002453:Cell Cycle; D016147:Genes, Tumor Suppressor; D006801:Humans; D000860:Hypoxia; D006899:Mixed Function Oxygenases / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D009389:Neovascularization, Pathologic; D010100:Oxygen / Q000378:metabolism*; D051059:PTEN Phosphohydrolase; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000502:physiology; D019700:Thrombospondin 1 / Q000378:metabolism; D015533:Transcriptional Activation; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D051794:Von Hippel-Lindau Tumor Suppressor Protein
D016160:Retinoblastoma Protein; D019700:Thrombospondin 1; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D006899:Mixed Function Oxygenases; D044767:Ubiquitin-Protein Ligases; D051794:Von Hippel-Lindau Tumor Suppressor Protein; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human; C497446:VHL protein, human; D010100:Oxygen