title: Role of adjuvant cryosurgery in intralesional treatment of sacral tumors.
abstract: BACKGROUND
  Cryosurgery is an adjuvant surgical technique for the treatment of benign aggressive, low-grade malignant and metastatic tumors of long bones. It has been used rarely to treat sacral tumors, mainly because of potential damage to nerves, blood vessels, and intrapelvic organs. The authors described their experience with this procedure and provided medium and long-term follow-up results.
  
  
  METHODS
  Fifteen procedures of cryosurgery of the sacrum were performed in 14 patients to improve the therapeutic outcome of a variety of tumors. The patient group included 7 males and 7 females with a mean age of 42 +/- 24 years. Three patients were younger than 20 years of age. The procedures were performed at the Tel Aviv Sourasky Medical Center between January 1991 and January 1999. There were seven benign aggressive lesions (four giant cell tumors and three aneurysmal bone cysts), one benign schwannoma, one low-grade chondrosarcoma, five metastatic carcinomas, and one high-grade Ewing sarcoma, all localized at level S(2) or higher. Eight of the bone tumors also involved significant anterior or posterior soft tissue. All patients had severe preoperative pain radiating to the buttocks, perineum, and lower limbs and 9 (64%) patients had bladder and/or rectal dysfunction. Invasive diagnostic procedures and radiation (if warranted) preceded surgery. Sacral posterior fenestration and burr drilling were followed by two-cycle cryosurgery using the open pour technique or the argon-helium-based heat-freeze system.
  
  
  RESULTS
  All interventions were performed under combined general and regional anesthesia and concluded uneventfully with moderate blood loss. Thirteen patients were discharged home after 8 +/- 5 days (one patient remained hospitalized for 30 days). Only two patients experienced local disease recurrence during a 3-11-year follow-up period: one was retreated successfully by cryosurgery and the other underwent sacrectomy and radiotherapy elsewhere, with a subsequent loss of visceral functions. No patient suffered chronic pain, deep wound infections, or significant neurologic deficits and all were satisfied with the esthetic outcome.
  
  
  CONCLUSIONS
  Cryosurgery is a conservative, feasible, and safe adjuvant technique in the treatment of sacral tumors. It is associated with minimal permanent neurologic and vascular injury compared with sacrectomy.
authors.affiliation: National Orthopedic Oncology Unit, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Kollender
authors.forename: Issac
authors.initials: I
authors.lastname: Meller
authors.forename: Jacob
authors.initials: J
authors.lastname: Bickels
authors.forename: Gideon
authors.initials: G
authors.lastname: Flusser
authors.forename: Josefin
authors.initials: J
authors.lastname: Issakov
authors.forename: Ofer
authors.initials: O
authors.lastname: Merimsky
authors.forename: Nissim
authors.initials: N
authors.lastname: Marouani
authors.forename: Alexander
authors.initials: A
authors.lastname: Nirkin
authors.forename: Avi A
authors.initials: AA
authors.lastname: Weinbroum
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000765:Anesthesia, Conduction; D000768:Anesthesia, General; D001859:Bone Neoplasms / Q000601:surgery*; D003452:Cryosurgery / Q000009:adverse effects / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D012086:Reoperation; D012447:Sacrum; D016896:Treatment Outcome