Anti-ganglioside antibodies in idiopathic and hereditary cerebellar degeneration.
Cerebellar degeneration has been associated with gluten sensitivity and celiac disease. Patients with celiac disease may have neuropathy and antibodies to gangliosides. The authors investigated the presence of antiganglioside antibodies in 22 patients with hereditary and nonhereditary ataxia and found 64% reactive in a novel agglutination test.
Shill
Holly A
HA
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA.
Alaedini
Armin
A
Bushara
K O
KO
Latov
Norman
N
Hallett
Mark
M
D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D020274:Autoimmune Diseases of the Nervous System / Q000276:immunology; D002524:Cerebellar Ataxia / Q000235:genetics / Q000276:immunology*; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000235:genetics / Q000276:immunology; D013132:Spinocerebellar Degenerations / Q000235:genetics / Q000276:immunology*
D001323:Autoantibodies; D005732:Gangliosides