title: Treatment of 522 patients with Nevus of Ota with Q-switched Alexandrite laser.
abstract: OBJECTIVE
  To evaluate the clinical response of Nevus of Ota to Q-switched Alexandrite laser, and analyze factors that influence the treatment outcome.
  
  
  METHODS
  A total of 522 patients treated with Q-switched Alexandrite laser were included in the study. Single and multiple variate analyses of various factors were performed.
  
  
  RESULTS
  Satisfactory result was observed in all patients, none of whom developed scarring. Clinical response was improved with additional treatment sessions. The clinical response of the 20 - 27-week treatment interval group was significantly better than that of the 12 - 19-week interval group, but showed no significant difference as compared with both the 28 - 35 and > or = 36-week interval group. Zygomatic, buccal and frontal areas showed better response than ocular and temporal areas. Treatment session, interval, and fluence were significant factors identified by multivariate analysis.
  
  
  CONCLUSIONS
  Q-switched Alexandrite laser is an ideal method for treating Nevus of Ota without injury. The number of treatment sessions is more important than interval or fluence.
authors.affiliation: Department of Dermatology, Huashan Hospital, Medical College of Fudan University, Shanghai 200040, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Lu
authors.forename: Lihua
authors.initials: L
authors.lastname: Fang
authors.forename: Sheng
authors.initials: S
authors.lastname: Jiao
authors.forename: Wen
authors.initials: W
authors.lastname: Huang
authors.forename: Junpang
authors.initials: J
authors.lastname: Chen
authors.forename: Xiasheng
authors.initials: X
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005153:Facial Neoplasms / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D053685:Laser Therapy / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009507:Nevus of Ota / Q000473:pathology / Q000601:surgery*; D010859:Pigmentation Disorders / Q000209:etiology; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*