title: A randomized controlled study of three targets of propofol plasma concentration in patients undergoing uterine dilation and curettage.
abstract: OBJECTIVE
  To compare the efficacy and the complications of three target levels of propofol plasma concentration in patients undergoing uterine dilation and curettage.
  
  
  METHODS
  Sixty-nine patients were randomly allocated to receive propofol target controlled infusion at different target concentrations of 4 (group I), 5 (group II) and 6 (group III) mcg/mL combined with 1 microg/kg of fentanyl and 66% of nitrous oxide. Patients' movement during the procedure, hemodynamic variables, oxygen saturation, end tidal carbon dioxide, time to sleep and awake, and bispectral index score were recorded.
  
  
  RESULTS
  Seven patients in group I, one in group II, and none in group III (P < 0.05) moved grossly during the procedure. More patients in group III developed hypotension (5 vs 0 and 2 in group I and II, P < 0.05), but no difference was found regarding respiratory complication. No difference was found in time to sleep, but time to wake was longer in group III.
  
  
  CONCLUSIONS
  Propofol infusion at the target concentration of 5 microg/mL was recommended for uterine dilation and curettage when it was administered with fentanyl 1 microg/kg and nitrous oxide 66% under close monitoring and appropriate respiratory management.
authors.affiliation: Department of Anesthesia, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Pratumwan, Bangkok, Thailand. ketchada@hotmail.com
authors.forename: Ketchada
authors.initials: K
authors.lastname: Uerpairojkit
authors.forename: Pakorn
authors.initials: P
authors.lastname: Urusopone
authors.forename: Wanna
authors.initials: W
authors.lastname: Somboonviboon
mesh_terms: D000293:Adolescent; D000328:Adult; D000762:Anesthesia Recovery Period; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D004107:Dilatation and Curettage; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D010100:Oxygen / Q000097:blood; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D015656:Respiratory Mechanics / Q000187:drug effects; D016896:Treatment Outcome; D014599:Uterus / Q000601:surgery*
chemical_list: D018686:Anesthetics, Intravenous; D010100:Oxygen; D015742:Propofol