title: Stroke following Bothrops spp. snakebite.
abstract: OBJECTIVE
  To determine the prevalence and subtypes of cerebrovascular complications of Bothrops spp. snakebites.
  
  
  METHODS
  The authors studied 309 consecutive patients bitten by Bothrops spp. who attended a large general hospital. Special emphasis was placed on the time elapsed between the bite and admission to the hospital, clinical manifestations, laboratory findings, severity of envenomation, CT findings, and outcome.
  
  
  RESULTS
  Eight of 309 patients (2.6%) developed a cerebrovascular event. Six presented >8 hours after being bitten, and all had clinical and laboratory evidence of severe envenoming. CT revealed intracranial bleeding in seven patients and multiple brain infarcts in one. Hemorrhages were located in the subcortical white matter of the cerebral hemispheres in five patients, in the cerebellum in one, and in the subarachnoid space in one. All patients with intracranial hemorrhage had a bleeding disorder, and the patient with cerebral infarcts may have had angiitis. Five of the eight patients died despite therapy, and the remaining three had irreversible sequelae.
  
  
  CONCLUSIONS
  The prevalence of cerebrovascular complications related to Bothrops spp. bites is 2.6%. Intracranial hemorrhages are more frequent than cerebral infarcts. The prognosis of these patients is poor.
authors.affiliation: Department of Neurology, Luis Vernaza Hospital, Guayaquil, Ecuador.
authors.forename: Aurelio
authors.initials: A
authors.lastname: Mosquera
authors.forename: Luis A
authors.initials: LA
authors.lastname: Idrovo
authors.forename: Alfonso
authors.initials: A
authors.lastname: Tafur
authors.forename: Oscar H
authors.initials: OH
authors.lastname: Del Brutto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D017837:Bothrops; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000209:etiology; D002544:Cerebral Infarction / Q000453:epidemiology / Q000209:etiology; D002648:Child; D003435:Crotalid Venoms / Q000009:adverse effects / Q000494:pharmacology; D004484:Ecuador / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012909:Snake Bites / Q000150:complications*; D020521:Stroke / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D014057:Tomography, X-Ray Computed
chemical_list: D003435:Crotalid Venoms