Can a proteomics strategy be used to identify the anti-malarial activity of chloroquine?
Interest in the mechanism of action of chloroquine is intense partly because of the emergence of drug-resistant parasites. Chloroquine resistance has been genetically linked to mutations in a parasite protein (PfCRT) that might confer resistance by inhibiting chloroquine accumulation in infected erythrocytes. Now chloroquine-binding proteins in malaria-infected erythrocytes, surprisingly, have been identified as human aldehyde dehydrogenase 1 and quinone reductase 2, raising the interesting possibility that the target of the anti-malarial activity of chloroquine might be a host enzyme.
Petri
William A
WA
Division of Infectious Diseases, University of Virginia School of Medicine, PO Box 801340, MR4 Building Room 2115, Charlottesville 22908-1340, USA. wap3g@virginia.edu
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D002738:Chloroquine / Q000627:therapeutic use*; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000235:genetics; D040901:Proteomics / Q000379:methods*
D000962:Antimalarials; D002738:Chloroquine