title: International prospective evaluation of scintimammography with (99m)technetium sestamibi.
abstract: BACKGROUND
  The purpose of this study is to evaluate the efficacy of scintimammography with (99m)Technetium-Sestamibi for the diagnosis of breast cancer.
  
  
  METHODS
  This was a multicenter prospective cohort clinical trial. A total of 1,734 women were enrolled of whom 1,243 had complete data upon study completion.
  
  
  RESULTS
  The mean +/- standard error age of the patients is 56 +/-12 years (with a range of 19 to 94). Mammographic results were classified by the Breast Imaging Reporting and Data System (BIRADS) as 199 (16%) BIRADS 5, 149 (12%) BIRADS 4, 199 (16%) BIRADS 3, and 696 (56%) BIRADS 2 or 1. Scintimammography was positive for 322 (26%) of the patients and negative for 921 (76%). Histopathology showed malignancy for 201 (16%) of the patients. Sensitivity and specificity of scintimammography was estimated 93% and 87% respectively. A positive predictive value (PPV) of 58% with a negative predictive value of 98% were calculated.
  
  
  CONCLUSIONS
  The present study suggests that scintimammography with (99m)Technetium-Sestamibi is highly accurate for the detection of breast cancer.
authors.affiliation: Department of Surgery, University of Montreal, Hôpital Sacré-Coeur, Montreal, Quebec, Canada. tssamp@jssresearch.com
authors.forename: Fotini S
authors.initials: FS
authors.lastname: Sampalis
authors.forename: Ronald
authors.initials: R
authors.lastname: Denis
authors.forename: Daniel
authors.initials: D
authors.lastname: Picard
authors.forename: David
authors.initials: D
authors.lastname: Fleiszer
authors.forename: Ginette
authors.initials: G
authors.lastname: Martin
authors.forename: Edgard
authors.initials: E
authors.lastname: Nassif
authors.forename: John S
authors.initials: JS
authors.lastname: Sampalis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi