title: Nasal Rosai-Dorfman disease with intracranial involvement: a case report.
abstract: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a rare but distinctive entity. It was initially described as a nodal-based disease but later found to affect a variety of extranodal sites. The diagnosis of Rosai-Dorfman disease is based on the unique histologic changes that are characterized by proliferation of S-100 protein-positive histiocytes, the presence of emperipolesis, and a mixture of prominent lymphoplasmacytic infiltrates. The etiology of Rosai-Dorfman disease is unknown. It usually runs a benign clinic course and may resolve spontaneously, but cases running protracted courses have also been reported. We report an unusual case of recurrent extranodal Rosai-Dorfman disease in nasal and paranasal cavities with intracranial involvement surviving for more than 9 years.
authors.affiliation: Department of Otolaryngology, China Medical College Hospital, Taichung, Taiwan.
authors.forename: Yu-Chien
authors.initials: YC
authors.lastname: Chang
authors.forename: Ming-Hsui
authors.initials: MH
authors.lastname: Tsai
authors.forename: Chi-Long
authors.initials: CL
authors.lastname: Chen
authors.forename: Chon-Haw
authors.initials: CH
authors.lastname: Tsai
authors.forename: Alex Ying-Shyuan
authors.initials: AY
authors.lastname: Lee
mesh_terms: D001927:Brain Diseases / Q000473:pathology*; D015618:Histiocytosis, Sinus / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence