E-cadherin gene polymorphism and risk of urothelial cancer.
The E-cadherin is important in cell-cell adhesion and in the development and maintenance of the epithelial phenotype. A -160C-->A polymorphism in the promoter region of E-cadherin has been shown to decrease gene transcription. This allelic variation may be a potential genetic marker that can help identify those individuals at higher risk for invasive/metastatic disease. We studied the effect of E-cadherin gene polymorphism on urothelial cancer susceptibility in a case control study of 314 urothelial cancer patients and 314 age-sex matched controls, to determine whether this polymorphism is a biomarker for the risk and how aggressive the disease is. The frequency with which the subjects carried E-cadherin A/A genotype was significantly higher in the urothelial cancer patients than in the healthy control subjects (OR=2.32, 95% CI 1.03-5.22). Subdividing urothelial cancer according to tumor differentiation and stage, we found no association between E-cadherin polymorphism and poorly-differentiation and invasiveness of urothelial cancer. Furthermore, no significant association between E-cadherin polymorphism and recurrence rate of urothelial cancer patients was found. The present study demonstrates for the first time that E-cadherin A/A genotype may be associated with susceptibility to urothelial cancer, but not with the progression of disease.
Tsukino
Hiromasa
H
Department of Public Health, School of Medicine, Miyazaki Medical College, 5200 Kihara, 889-1692 Miyazaki, Japan.
Kuroda
Yoshiki
Y
Nakao
Hiroyuki
H
Imai
Hirohisa
H
Inatomi
Hisato
H
Kohshi
Kiyotaka
K
Osada
Yukio
Y
Katoh
Takahiko
T
D000328:Adult; D000368:Aged; D015820:Cadherins / Q000235:genetics*; D016022:Case-Control Studies; D002454:Cell Differentiation; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011401:Promoter Regions, Genetic / Q000235:genetics*; D014516:Ureteral Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D014571:Urologic Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology
D015820:Cadherins