[Changes of relative variables about prethrombosis state and its clinical significance in patients with pregnancy induced hypertension].
OBJECTIVE
To explore the changes of the hemorrheology coagulation and fibrinolytic system in patients with pregnancy induced hypertension (PIH).


METHODS
To examine the platelet alphagranule membrane protein (GMP-140), Von-Willebrand factor (vWF), antithrombin III activity (AT-III), plasminogen activity (PLG), the activity of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) in 30 non-pregnancy women, 30 normal late pregnancy women and 50 pregnancy induced hypertension women.


RESULTS
In PIH group vWF [(156 +/- 23)%], GMP-140 [(23.9 +/- 3.6) microg/L], Fbg [(15.5 +/- 0.8) g/L], PLG [(141 +/- 9)%], D-Dimer [(1.42 +/- 0.32) mg/L], PAI [(9.2 +/- 0.8) kU/L] were obviously higher than those of control group. AT-III, ProC in PIH group were lower than that of the control group (P < 0.01). t-PA has no significant differences (P > 0.05).


CONCLUSIONS
Prethrombotic state was shown in normal late pregnancy women. Obvious prethrombotic state was shown in patients with pregnancy induced hypertension women.
Liu
Bao-ying
BY
Department of Obstetrics and Gynecology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Zhong
Mei
M
Yu
Yan-hong
YH
Zheng
Lei
L
Wang
Qian
Q
Guo
Wen-li
WL
D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D019007:P-Selectin / Q000097:blood*; D010314:Partial Thromboplastin Time; D015539:Platelet Activation; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D018180:Thrombomodulin / Q000097:blood*; D019851:Thrombophilia / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000097:blood; D014841:von Willebrand Factor / Q000032:analysis*
D019007:P-Selectin; D018180:Thrombomodulin; D014841:von Willebrand Factor; D000990:Antithrombin III; D010959:Tissue Plasminogen Activator