title: Supra-tarsal injection of dexamethasone in the treatment of patients with refractory vernal keratoconjunctivitis.
abstract: The response to supratarsal injection of dexamethasone in severe refractory vernal keratoconjunctivitis was studied in 20 patients (14 males and 6 females) at the ophthalmology department of Menelik II Hospital, Addis Ababa in 1997. Majority of the patients were in the age range of 11-20 years with mean age of 14.6 years. Although all patients experienced relief of symptoms in the first 2 days of dexamethasone injection, symptoms recurred in the majority 16 (80%) of the patients. Cobble stone papillae and limbal signs disappeared in 2 (11%) and 5 (38%) of the patients respectively. Resolution of limbal form of the disease is more dramatic when compared to the palpebral form. This study showed that supratarsal injection of dexamethasone in severe vernal keratoconjunctivitis is effective in few, partially effective in some and ineffective in many of our patients. Further studies, particularly a randomized controlled trial is recommended prior to utilization of this new therapeutic modality as a standard form of treatment in Ethiopian patients.
authors.affiliation: Ras Desta-Damtew Memorial Hospital, P.O. Box 1032, Addis Ababa, Ethiopia.
authors.forename: Mulu
authors.initials: M
authors.lastname: Lisanework
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002648:Child; D003233:Conjunctivitis, Allergic / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology; D003907:Dexamethasone / Q000008:administration & dosage*; D005002:Ethiopia / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007267:Injections; D008297:Male; D018579:Patient Selection; D012720:Severity of Illness Index; D017678:Sex Distribution; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D003907:Dexamethasone