title: Mucormycosis (zygomycosis) in a heart-kidney transplant recipient: recovery after posaconazole therapy.
abstract: We describe the case of a diabetic patient who developed a severe invasive fungal infection due to Rhizopus species postoperatively after a dual heart/kidney transplantation with subsequent intensive immunosuppressive therapy. No improvement was noted with amphotericin B (deoxycholate) therapy, but salvage treatment with the new azole antifungal posaconazole (200 mg orally 4 times daily) resulted in dramatic clinical improvement as early as 1 week after the initiation of therapy that continued through 23 weeks of treatment, with marked clinical, mycological, and radiological improvements and no adverse events.
authors.affiliation: Corporación para Investigaciones Biológicas, Medellín, Colombia.
authors.forename: Angela Ma
authors.initials: AM
authors.lastname: Tobón
authors.forename: Myrtha
authors.initials: M
authors.lastname: Arango
authors.forename: Darío
authors.initials: D
authors.lastname: Fernández
authors.forename: Angela
authors.initials: A
authors.lastname: Restrepo
mesh_terms: D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D048909:Diabetes Complications; D016027:Heart Transplantation; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy*; D011183:Postoperative Complications / Q000517:prevention & control*; D014230:Triazoles / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole