[Effect of gufuhuotang on hemorheology and lipid metabolism of hormonal necrosis of femoral head].
OBJECTIVE
To probe the of Gufuhuotang effect on hemorheology and lipid metabolism of hormonal necrosis of femoral head.


METHODS
32 male rabbits of New Zealand were divided at random into pathological pattern group, normal control group, low-dosage of Gufuhuotang group and high-dosage group; models of osteocyte necrosis of head of femur were made with intragluteal injection of hydroprednisone acetate; the rabbits were observed weekly and killed 6 weeks later and HE pathological section was made to observe hemorheology index and blood-liquid content, and then analysis and comparison were made.


RESULTS
Gufuhuotang could obviously decrease total blood low-shear viscosity, plasma viscosity, hemacocrit, serum cholesterol and triglyceride contents; under light microscope empty bone lacunas of femoral head were less, fat cells of medullary cavity were less and relatively small, and bone trabecula was sparse with no break.


CONCLUSIONS
Gufuhuotang has a distinct preventive and curative effect on rabbits' hormonal necrosis of femoral head.
Tian
Wei-ming
WM
TCM Hospital, Hebei Medical University, Shijiazhuang 050011, Hebei, China.
Wang
Wen-zhi
WZ
Wang
Xin-guo
XG
D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D005271:Femur Head Necrosis / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D018056:Hemorheology / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D011241:Prednisone; D011817:Rabbits; D011897:Random Allocation
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008055:Lipids; D011241:Prednisone