[Partial laryngectomy plus radiotherapy versus partial laryngectomy alone for laryngeal carcinoma].
OBJECTIVE
To investigate the effect of radiotherapy in the combined treatment of laryngeal cancer with partial laryngectomy.


METHODS
One hundred and seventy-one cases of laryngeal cancer were randomly separated into three groups of partial laryngectomy, partial laryngectomy with preoperative radiotherapy (dose 40-50Gy) and partial laryngectomy with postoperative radiotherapy(dose 51-70 Gy). The surgical procedures included cordectomy, vertical partial laryngectomy, horizontal partial laryngectomy and near total laryngectomy.


RESULTS
The overall 5-year survival rate was 82% (123/150). The 5-year survival rates for surgery alone group (56 cases), surgery with preoperative radiotherapy group(65 cases) and surgery with postoperative radiotherapy group(50 cases) were 85.7%, 80.7% and 79.5% respectively. There was no significant difference among the groups(chi 2 = 0.703, P = 0.704). Analysis of survival rates revealed a significant difference among the different stages(chi 2 = 12.248, P = 0.007). All 171 cases except 3 that had near total laryngectomy achieved satisfactory phonation.


CONCLUSIONS
Neither preoperative radiotherapy nor postoperative radiotherapy can improve the 5-year survival rate of laryngeal cancer with partial laryngectomy. All patients with partial laryngectomy got satisfactory phonation.
Zeng
Z
Z
Department of Head and Neck Surgery, Cancer Center, Sun Yatsen University of Medical Sciences, Guangzhou 510060, China.
Chen
F
F
Zhang
Q
Q
Yang
A
A
Zeng
X
X
Cheng
W
W
Guo
Z
Z
Xu
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods / Q000534:rehabilitation; D008297:Male; D008875:Middle Aged; D015996:Survival Rate