title: Is attenuation of extracellular dopamine increase in the nucleus accumbens the major mechanism by which dexmedetomidine increases the cocaine seizure threshold in rats?
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nakao
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants; D003042:Cocaine / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D020927:Dexmedetomidine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D018765:Dopamine Uptake Inhibitors / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D005110:Extracellular Space / Q000187:drug effects / Q000378:metabolism; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012640:Seizures / Q000139:chemically induced* / Q000517:prevention & control*
chemical_list: D000316:Adrenergic alpha-Agonists; D000927:Anticonvulsants; D018765:Dopamine Uptake Inhibitors; D020927:Dexmedetomidine; D003042:Cocaine; D004298:Dopamine