title: Therapeutic strategies for Parkinson's disease based on data derived from genetic research.
abstract: Following the identification of mutations in alpha-synuclein as the cause of some rare forms of familial Parkinson's disease (PD), genetic research has uncovered numerous gene loci of PD. Meanwhile, several neurodegenerative diseases have been shown to accumulate a-synuclein in neuronal and glial cells summarizing this group of diseases as synucleinopathies. All currently known gene defects causing PD alter the ubiquitin-proteasomal pathway of protein degradation. Identification of these disease mutations allows studying the functional consequences which lead to cellular dysfunction and cell death in cell culture and transgenic animal models, to identify therapeutic targets and to test potential protective strategies in these models.
authors.affiliation: Department of Medical Genetics, University of Tübingen, Calwer Strasse 7, 72076 Tübingen, Germany. olaf.riess@med.uni-tuebingen.de
authors.forename: Olaf
authors.initials: O
authors.lastname: Riess
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg
authors.forename: Rejko
authors.initials: R
authors.lastname: Krüger
authors.forename: Jörg B
authors.initials: JB
authors.lastname: Schulz
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D004195:Disease Models, Animal; D005826:Genetics, Medical / Q000379:methods*; D006801:Humans; D016233:Immunotherapy, Active; D007501:Iron / Q000502:physiology; D017628:Microglia / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D013378:Substantia Nigra / Q000378:metabolism; D051843:Synucleins; D051844:alpha-Synuclein
chemical_list: D000276:Adjuvants, Immunologic; D000975:Antioxidants; D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein; D007501:Iron