[Molecular mechanisms regulating transport of low molecular weight substances in the hepatocyte].
Transporters of sinusoidal and lateral membranes mediate uptake of inorganic and organic substances to hepatocyte. In hepatocyte lipophilic compounds are biotransformed (hydroxylated and conjugated) and excreted into bile and urine. Vectorial movement of solutes and water from blood to bile is maintained by pumps of ABC superfamily secreting bile salts (bile acid dependent flow) and other solutes: bilirubin, phospholipids, glutathione and inorganic salts (bile acid independent flow).
Zwierz
Krzysztof
K
Zakład Biochemii Farmaceutycznej Akademii Medycznej w Białymstoku. kzwie@amb.edu.pl
Wielgat
Przemysław
P
Borzym-Kluczyk
Małgorzata
M
D000818:Animals; D000838:Anions / Q000378:metabolism* / Q000493:pharmacokinetics*; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D001692:Biological Transport / Q000502:physiology; D001834:Body Water / Q000378:metabolism; D022781:Hepatocytes / Q000378:metabolism*; D006801:Humans; D006900:Hydroxylation; D008970:Molecular Weight; D012964:Sodium / Q000378:metabolism; D014556:Urine
D000838:Anions; D001647:Bile Acids and Salts; D012964:Sodium