title: [Enhancement of glutamate release in the extracellular space of nucleus accumbens during presentation of aversive or neutral stimuli instead of food reinforcement].
abstract: By means of in vivo microdialysis combined with HPLC/EC analysis it was shown that presentation to a rat of an inedible object (a piece of rubber) or an aversive object (food of bitter taste) instead of expected food caused a marked increase in extracellular glutamate level in n. accumbens. In rats not expecting food reinforcement, extracellular glutamate remained unchanged during presentation of these objects. Our findings suggest that dissociation between the expected biological value of a presented object and its real significance may be an important determinant for glutamate release control in n. accumbens during food behavior.
authors.affiliation: Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. nbs@infran.ru
authors.forename: N B
authors.initials: NB
authors.lastname: Saul'skaia
authors.forename: M O
authors.initials: MO
authors.lastname: Mikhaĭlova
mesh_terms: D000818:Animals; D001362:Avoidance Learning; D005110:Extracellular Space / Q000378:metabolism*; D005247:Feeding Behavior / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D017551:Microdialysis / Q000295:instrumentation; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012054:Reinforcement, Psychology
chemical_list: D018698:Glutamic Acid