title: The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani.
abstract: The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active compounds were in the reversed amidine series and six exhibited IC(50) values of less than 1 micro mol versus T. cruzi and five gave similar values versus L. donovani.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, GA 30303-3083, USA. dboykin@gsu.edu
authors.forename: Chad E
authors.initials: CE
authors.lastname: Stephens
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
authors.forename: Manar M
authors.initials: MM
authors.lastname: Salem
authors.forename: Karl A
authors.initials: KA
authors.lastname: Werbovetz
authors.forename: Farial
authors.initials: F
authors.lastname: Tanious
authors.forename: W David
authors.initials: WD
authors.lastname: Wilson
authors.forename: David W
authors.initials: DW
authors.lastname: Boykin
mesh_terms: D000578:Amidines / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D004247:DNA / Q000378:metabolism; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D019791:Guanidine / Q000031:analogs & derivatives / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007893:Leishmania donovani / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry / Q000378:metabolism; D011067:Poly dA-dT / Q000737:chemistry / Q000378:metabolism; D015800:Protozoan Proteins / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship; D013696:Temperature; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000578:Amidines; D005663:Furans; D009838:Oligodeoxyribonucleotides; D015800:Protozoan Proteins; D014344:Trypanocidal Agents; D011067:Poly dA-dT; D004247:DNA; D019791:Guanidine