From genes to aging in Drosophila.
Despite the intimate nature of the aging process we actually know little about it. In more recent years, work on a variety of organisms, utilizing approaches including demography, molecular genetics, and epidemiology, have challenged some of the more commonly held assumptions about the aging process. These studies have served to reinvigorate the field of aging research and are beginning to lead the way in a renaissance in aging research (Helfand and Inouye, 2002). Invertebrate model systems such as Drosophila and Caenorhabditis elegans that permit extensive genetic analysis are at the forefront of this renaissance.
Helfand
Stephen L
SL
Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA. shelfand@neuron.uchc.edu
Rogina
Blanka
B
D000375:Aging; D000818:Animals; D015415:Biomarkers; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D015870:Gene Expression; D017344:Genes, Insect; D006801:Humans; D008136:Longevity / Q000235:genetics; D008957:Models, Genetic; D009154:Mutation; D018384:Oxidative Stress
D015415:Biomarkers