title: Acute myelogenous leukemia complicated by acute necrotizing ulcerative gingivitis due to Aspergillus terreus.
abstract: Infections caused by Aspergillus terreus are rare but have been associated with a poor outcome in immunocompromised patients due to frequent resistance to conventional antifungal therapy. This report describes a case of a woman who developed acute necrotizing ulcerative gingivitis (ANUG) due to A. terreus during induction chemotherapy for acute myelogenous leukemia. She initially failed to respond to treatment with amphotericin B but the infection resolved following the introduction of oral itraconazole. Opportunistic infections caused by A. terreus are an emerging problem and can be associated with a high mortality rate. Early microbiological diagnosis is critical since resistance to amphotericin B is likely and itraconazole appears to be an effective treatment for this infection.
authors.affiliation: The Leukemtia/Bone Marrow Transplantation Program of British Columbia: Division of Hematology, Vancouver General Hospital, British Columbia Cancer Agency and the University of British Columbia, Vancouver, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Khoury
authors.forename: C F
authors.initials: CF
authors.lastname: Poh
authors.forename: M
authors.initials: M
authors.lastname: Williams
authors.forename: J C
authors.initials: JC
authors.lastname: Lavoie
authors.forename: T J
authors.initials: TJ
authors.lastname: Nevill
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001230:Aspergillus / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005892:Gingivitis, Necrotizing Ulcerative / Q000150:complications* / Q000382:microbiology*; D006801:Humans; D007223:Infant; D017964:Itraconazole / Q000494:pharmacology; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D017964:Itraconazole