Prenylated isoflavonoids from Millettia pervilleana.
From the root bark of Millettia pervilleana, which had shown significant cytotoxic activity, a 3-phenylcoumarin, named pervilleanine, two new pterocarpans, pervilline and pervillinine, and one known, emoroidocarpan, were isolated in addition to rotenone and 3alpha-hydroxyrotenone. The anticancer activity of two previously isolated isoflavanones, pervilleanone and 3'-O-demethylpervilleanone is reported.
Palazzino
Giovanna
G
Laboratorio di Chimica del Farmaco, Istituto Superiore di Sanità, V. le Regina Elena 299, I-00161 Rome, Italy. palazzin@iss.it
Rasoanaivo
Philippe
P
Federici
Elena
E
Nicoletti
Marcello
M
Galeffi
Corrado
C
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D033641:Millettia / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D036343:Pterocarpans / Q000737:chemistry / Q000302:isolation & purification; D012402:Rotenone / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D007529:Isoflavones; D036343:Pterocarpans; D012402:Rotenone