Complex pattern formation by a self-destabilization of established patterns: chemotactic orientation and phyllotaxis as examples.
Stable patterns can be generated by molecular interactions involving local self-enhancement and long-range inhibition. In contrast, highly dynamic patterns result if the maxima, generated in this way, become destabilized by a second antagonistic reaction. The latter must act local and must be long-lasting. Maxima either disappear and reappear at displaced positions or they move over the field as travelling waves. The wave can have unusual properties in that they can penetrate each other without annihilation. The resulting pattern corresponds to those observed in diverse biological systems. In the chemotactic orientation of cells, the temporary signals allow the localized extensions of protrusions under control of minute external asymmetries imposed by the chemoattractant. In phyllotaxis, these signals lead to successive leaf initiation, whereby the longer-lasting extinguishing reaction can cause a displacement of the subsequent leaf initiation site by the typical 137.5 degrees, the golden angle. On seashells, this patterns leads either to oblique lines that can cross each other or to oblique rows of dots. For some of the models animated simulations are available at http://www.eb.tuebingen.mpg.de/abt.4/meinhardt/theory.html.
Meinhardt
Hans
H
Max-Planck-Institut für Entwicklungsbiologie, Spemannstrasse 35 IV, Dept. Evolutionsbiologie, 72076 Tübingen, Germany. hans.meinhardt@tuebingen.mpg.de
D000818:Animals; D016764:Cell Polarity; D022081:Cell Surface Extensions / Q000502:physiology / Q000648:ultrastructure; D002633:Chemotaxis; D004058:Diffusion; D025461:Feedback, Physiological / Q000502:physiology; D008954:Models, Biological; D008974:Mollusca / Q000254:growth & development; D009024:Morphogenesis / Q000502:physiology*; D010507:Periodicity; D010858:Pigmentation / Q000502:physiology; D018515:Plant Leaves / Q000254:growth & development