[Effects of soy extract on lipid metabolism in ovariectomized rats].
OBJECTIVE
To study effects of soy extract on lipid metabolims in ovariectomized rats.


METHODS
90 Wistar rats were randomly divided into 9 groups: control group, sham group, model group, estrogen group, soy isoflavone group of high dose, soy isoflavone group of low dose, soy extract of high dose, soy extract of low dose, and soy polysaccharde group, 10 rats in each group. Except fer of control and sham groups, the test rats were ovariectomized. One week after operation, the rats were treated with different drugs. Six weeks after operation, the rats were killed, with serum and liver taken, and serumglycerol(sGT), cholesterol(sGC), LDL, HDL and liver homogenate hGT, hGC, measured.


RESULTS
The level of sGC, LDL in ovariectmized rats increased significantly, compared with that in control and sham groups. In liver both the level of hGT and hGC were higher than that in liver from control and sham groups. Administration of estrogen or soy extract or soy isoflavone could attenuate these in ovariectomized rats, but soy polysacchardes did not have any effects.


CONCLUSIONS
Ovariectomized rats have an imbalance of lipid metabolism, the level of hGT and hGC were increased, and administration of estrogen, soy extracts or soy isoflavone could decrease these changes induced by ovariectomizing.
Wang
Ji-feng
JF
Beijing University of Chinese Pharmacology and Medicine, Beijing 100029, China. wangjjff@263.net
Niu
Jian-zhao
JZ
Li
Hua
H
Zhang
Chi
C
Liu
Lian-qi
LQ
Gao
Bao-hua
BH
D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D004964:Estriol / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D010052:Ovariectomy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D011800:Quinestrol / Q000031:analogs & derivatives; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013025:Glycine max / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*
D007529:Isoflavones; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D014280:Triglycerides; C010722:nylestriol; D002784:Cholesterol; D004964:Estriol; D011800:Quinestrol