title: Reconstitution of lymphocyte populations and cytomegalovirus viremia or disease after allogeneic peripheral blood stem cell transplantation.
abstract: Early reconstitution of lymphoid populations was monitored by immunophenotyping in 57 allogeneic peripheral blood stem cell (allo-PBSC) transplant patients either with or without cytomegalovirus (CMV) viremia or disease. Cell counts for total lymphocytes and CD4(+) T cells above the percentile 60th at day 14 postransplant were associated significantly with CMV viremia-free survival within 120 days after transplant. Recovery of total lymphocyte, CD3(+), and CD8(+) T-cell counts proceeded at a more rapid rate in CMV viremic patients than in nonviremic patients, irrespective of whether preemptive treatment with ganciclovir had been prescribed. Significant expansion of CD8(+) and CD8(+) CD57(+) T-cell subsets was associated with recovery from viremia and no progression to CMV disease. Immunophenotyping may provide useful information for the clinical management of CMV infection in allo-PBSC transplant recipients.
authors.affiliation: Department of Hematology and Medical Oncology, School of Medicine, University of Valencia, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gutiérrez
authors.forename: Isabel
authors.initials: I
authors.lastname: Muñoz
authors.forename: Carlos
authors.initials: C
authors.lastname: Solano
authors.forename: Isabel
authors.initials: I
authors.lastname: Benet
authors.forename: Concepción
authors.initials: C
authors.lastname: Gimeno
authors.forename: Isabel
authors.initials: I
authors.lastname: Marugán
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Gea
authors.forename: Javier
authors.initials: J
authors.lastname: García-Conde
authors.forename: David
authors.initials: D
authors.lastname: Navarro
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage; D017252:CD3 Complex / Q000032:analysis; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D018959:CD57 Antigens / Q000032:analysis; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000097:blood / Q000628:therapy* / Q000821:virology; D005260:Female; D015774:Ganciclovir / Q000008:administration & dosage; D006801:Humans; D016130:Immunophenotyping; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013997:Time Factors; D014766:Viremia / Q000276:immunology
chemical_list: D000998:Antiviral Agents; D017252:CD3 Complex; D018959:CD57 Antigens; D015774:Ganciclovir