title: Synthesis of some 1-(2,4-dihydroxythiobenzoyl)imidazoles, -imidazolines and -tetrazoles and their potent activity against Candida species.
abstract: Various 1-(2,4-dihydroxythiobenzoyl)imidazoles, -imidazolines and -tetrazoles were synthesized and evaluated for their in vitro antifungal activity. Compounds were prepared by the reaction of sulfinyl-bis-(2,4-dihydroxythiobenzoyl) with properly substituted azoles. The MIC values against the Candida albicans ATCC 10231 strain, the azole-resistant clinical isolates of C. albicans and non-Candida species were determined. Tetrazole derivatives were the most active against C. albicans, imidazoline derivatives against non-Candida species. All compounds showed higher activity than that of comparable drugs.
authors.affiliation: Department of Chemistry, University of Agriculture, Akademicka 15, 20-950 Lublin, Poland. jmaty@agros.ar.lublin.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Matysiak
authors.forename: Andrzej
authors.initials: A
authors.lastname: Niewiadomy
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Krajewska-Kułak
authors.forename: Grazyna
authors.initials: G
authors.lastname: Macik-Niewiadomy
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D013777:Tetrazoles