Direct access of drugs to the human brain after intranasal drug administration?
It has been suggested that intranasal (IN) drug delivery could be used to administer drugs directly to the brain, bypassing the blood-brain barrier. Conclusive evidence of this proposed route of drug transport has not been observed by IN-IV comparison. In eight neurosurgery patients with a CSF drain, the uptake in CSF and plasma after IN and IV drug administration was compared. No evidence of direct access of the drugs from the nose to the CSF was found.
Merkus
Paul
P
Department of Otorhinolaryngology and Head and Neck Surgery, Academic Medical Center, University of Amsterdam, The Netherlands. P.Merkus@VUmc.nl
Guchelaar
Henk-Jan
HJ
Bosch
D Andries
DA
Merkus
Frans W H M
FW
D000281:Administration, Intranasal; D000328:Adult; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D006879:Hydroxocobalamin / Q000008:administration & dosage* / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics; D007275:Injections, Intravenous; D008297:Male; D008550:Melatonin / Q000008:administration & dosage* / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics; D008875:Middle Aged
D008550:Melatonin; D006879:Hydroxocobalamin