title: Routine patch testing with frullanolide mix: an European Environmental and Contact Dermatitis Research Group multicentre study.
abstract: Contact sensitivity to plants containing 1 or more sesquiterpene lactones (SLs) is difficult to diagnose. The mixture of SLs (SL mix) has been shown to detect only about 60% of sensitized individuals. In order to improve the diagnosis of sensitization to plants containing SLs, we have tested a mixture of frullanolides contained in Frullania dilatata and Frullania tamarisci at 3 different concentrations (0.01%, 0.033% and 0.1% in petrolatum). 8605 consecutive eczema patients in 1 North American and 15 European dermatology departments were tested with this mix, and 0.35% of positive cases to the different concentrations were found. Routine use of this mix permitted detection of only a small percentage of extra cases and did not improve the SL mix score. The frullanolide mix should therefore be restricted to investigations in particular geographical zones and/or in particular occupations.
authors.affiliation: Department of Dermatology, CHU de Bordeaux, Hôpital Saint André, Bordeaux, France.
authors.forename: G
authors.initials: G
authors.lastname: Ducombs
authors.forename: J P
authors.initials: JP
authors.lastname: Lepoittevin
authors.forename: V
authors.initials: V
authors.lastname: Berl
authors.forename: K E
authors.initials: KE
authors.lastname: Andersen
authors.forename: F M
authors.initials: FM
authors.lastname: Brandão
authors.forename: D P
authors.initials: DP
authors.lastname: Bruynzeel
authors.forename: M
authors.initials: M
authors.lastname: Bruze
authors.forename: J G
authors.initials: JG
authors.lastname: Camarasa
authors.forename: P J
authors.initials: PJ
authors.lastname: Frosch
authors.forename: A
authors.initials: A
authors.lastname: Goossens
authors.forename: J M
authors.initials: JM
authors.lastname: Lachapelle
authors.forename: A
authors.initials: A
authors.lastname: Lahti
authors.forename: C J
authors.initials: CJ
authors.lastname: Le Coz
authors.forename: H I
authors.initials: HI
authors.lastname: Maibach
authors.forename: T
authors.initials: T
authors.lastname: Menné
authors.forename: S
authors.initials: S
authors.lastname: Seidenari
authors.forename: S
authors.initials: S
authors.lastname: Shaw
authors.forename: A
authors.initials: A
authors.lastname: Tosti
authors.forename: J D
authors.initials: JD
authors.lastname: Wilkinson
mesh_terms: D000485:Allergens / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology; D005060:Europe / Q000453:epidemiology; D005260:Female; D037961:Frullania; D006801:Humans; D007536:Isomerism; D008297:Male; D012495:San Francisco / Q000453:epidemiology; D012717:Sesquiterpenes / Q000009:adverse effects*
chemical_list: D000485:Allergens; D012717:Sesquiterpenes; C007787:frullanolide