title: [A case of subependymal giant cell astrocytoma not associated with tuberous sclerosis].
abstract: The authors present a case of a subependymal giant cell astrocytoma (SGCA) not associated with tuberous sclerosis. On admission, a six-year-old boy had obstructive hydrocephalus caused by a huge intraventricular tumor. Preoperative T1-weighted MR images with gadolinium showed heterogeneous enhancement of the lesion. The tumor was totally removed through a right transcortical approach with frontal craniotomy. Immunohistochemical staining for glial fibrillary acidic protein (GFAP) showed a positive reaction in some of the large tumor cells and the labeling index of MIB-1 was < 1.0%. Histological examinations revealed SGCA. He has no other evidence of tuberous sclerosis at present, but the patient in this case is an infant, so there is a possibility of his being diagnosed as tuberous sclerosis in the future. Therefore, systemic regular follow-up is recommended, even when his condition is asymptomatic.
authors.affiliation: Department of Neurosurgery, Hiroshima City Asa Hospital, 2-1-1 Kabe-minami, Kita-ku, Asa, Hiroshima-city, Hiroshima 731-0293, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Shuichi
authors.initials: S
authors.lastname: Oki
authors.forename: Keisuke
authors.initials: K
authors.lastname: Migita
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Isobe
authors.forename: Takahito
authors.initials: T
authors.lastname: Okazaki
authors.forename: Shinya
authors.initials: S
authors.lastname: Nabika
mesh_terms: D001254:Astrocytoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D002551:Cerebral Ventricle Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D002648:Child; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D014402:Tuberous Sclerosis
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA