title: gamma-Secretase inhibitors--from molecular probes to new therapeutics?
authors.affiliation: Merck Sharp and Dohme Research Laboratories, Department of Medicinal Chemistry, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK.
authors.forename: Timothy
authors.initials: T
authors.lastname: Harrison
authors.forename: Dirk
authors.initials: D
authors.lastname: Beher
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000201:enzymology*; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; D015195:Drug Design; D010450:Endopeptidases / Q000502:physiology*; D006801:Humans; D015335:Molecular Probes; D019920:Photoaffinity Labels; D011480:Protease Inhibitors / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D015335:Molecular Probes; D019920:Photoaffinity Labels; D011480:Protease Inhibitors; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human