[Immunization of rats with bovine serum albumin conjugate with dopamine or 5-hydroxytryptamine prevents the development of experimental MPTP-induced depressive syndrome. An electrophysiological study].
In electrophysiological experiments in Wistar rats it was shown that preventive immunization of animals with bovine serum albumin conjugated with dopamine or 5-hydroxytryptamine or with bovine serum albumin alone partly protects against the development of experimental MPTP-induced depressive syndrome. Signs of depressive-like state such as decrease in REM-sleep latency and the development of epileptiform activity in caudate putamen were not observed in immunized animals, whereas REM-sleep proportion in the total sleep structure was increased. Changes in the spectral characteristics of brain electric activity and sleep structure during development of experimental MPTP-induced syndrome in immunized rats are antigen-specific and reflect the functional shifts in neurotransmitter systems, both in those which are the target of the immune action and those sensitive to alterations in the immune state of a body.
Pankova
N B
NB
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Vetrilé
L A
LA
Basharova
L A
LA
Krupina
N A
NA
Khlebnikova
N N
NN
Rodina
V I
VI
Kryzhanovskiĭ
G N
GN
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects; D003863:Depression / Q000139:chemically induced* / Q000517:prevention & control*; D004298:Dopamine / Q000008:administration & dosage*; D015259:Dopamine Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004569:Electroencephalography; D004594:Electrophysiology / Q000379:methods; D007114:Immunization / Q000379:methods*; D008297:Male; D011699:Putamen / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000008:administration & dosage*; D012710:Serum Albumin, Bovine / Q000008:administration & dosage*; D012895:Sleep, REM / Q000502:physiology; D018074:Vaccines, Conjugate / Q000008:administration & dosage
D015259:Dopamine Agents; D018074:Vaccines, Conjugate; D012710:Serum Albumin, Bovine; D012701:Serotonin; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine