Transcription factors: new targets for antiallergic therapy.
Due to their pivotal role in the fast transmission of signals from cell surface receptors to the nucleus, resulting in gene expression, transcriptional factors play an important part in the physiology of cells. Recently, a number of transcription factors have been identified that are involved in the pathogenesis of allergic diseases. In order to attenuate the development of allergen-mediated diseases, new strategies have been developed to influence these transcription factors in vivo. Among these, the use of oligodeoxynucleotide decoy has emerged as a new tool with promising results for therapeutical and experimental purposes.
Quarcoo
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Department of Pediatric Pneumology and Immunology, Charité-Humboldt University, Berlin, Germany.
Hamelmann
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D000818:Animals; D004195:Disease Models, Animal; D015195:Drug Design; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000235:genetics*; D051379:Mice; D016376:Oligonucleotides, Antisense / Q000494:pharmacology* / Q000627:therapeutic use; D014157:Transcription Factors / Q000187:drug effects*; D014158:Transcription, Genetic / Q000187:drug effects*
D016376:Oligonucleotides, Antisense; D014157:Transcription Factors