title: The role of CTLA4-Ig in a mouse model against allergic asthma.
abstract: OBJECTIVE
  To investigate CTLA4-Ig's potential role in therapy for allergic asthma by blocking B7/CD28 interactions with cytotoxic T lymphocyte antigen 4-Ig (CTLA4-Ig).
  
  
  METHODS
  We divided BALB/C mice into the three groups: Sham/Sham (control), ovalbumin (OVA)/OVA and mCTLA4-Ig. Blood, bronchoalveolar lavage, histology and determination of cytokines were performed 24 hours after airway challenge.
  
  
  RESULTS
  In the OVA/OVA group, the number of cells, the percentage of inflamed cells and the level of IL-4 in BALF were increased. Airways in our murine model for allergic asthma underwent pathological changes, which were significantly reduced after treatment with mCTLA4-Ig.
  
  
  CONCLUSIONS
  Blockage of co-stimulation with mCTLA4-Ig can inhibit allergy-specific response of T cells, and asthmatic response as well.
authors.affiliation: Department of Respiratory Medicine, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China. huan_yin2000@yahoo.com
authors.forename: Huanying
authors.initials: H
authors.lastname: Wan
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
authors.forename: Shaoguang
authors.initials: S
authors.lastname: Huang
authors.forename: Weiwu
authors.initials: W
authors.lastname: Deng
mesh_terms: D000069594:Abatacept; D000818:Animals; D001249:Asthma / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D018796:Immunoconjugates / Q000627:therapeutic use*; D015847:Interleukin-4 / Q000097:blood; D007958:Leukocyte Count; D051379:Mice; D008807:Mice, Inbred BALB C; D014132:Trachea / Q000473:pathology
chemical_list: D018796:Immunoconjugates; D015847:Interleukin-4; D000069594:Abatacept