A gene for familial isolated chronic nail candidiasis maps to chromosome 11p12-q12.1.
Chronic mucocutaneous candidiases (CMC) are a group of rare disorders where an altered immune response against Candida leads to persistent and/or recurrent infections of the skin, nails, and mucous membranes. We analysed a five-generation Italian family with an isolated form of CMC, affecting nails only, in the presence of low serum concentration of intercellular adhesion molecule I (ICAM-1). We excluded linkage to candidate regions on chromosomes 2p (CMC with thyroid disease), 21q22.3 (APECED), and 19q13 (ICAM-1). We then carried out a genome-wide scan and assigned the CMC locus to a 19 cM pericentromeric region on chromosome 11.
Mangino
M
M
1IRCCS-CSS San Giovanni Rotondo, CSS-Mendel, Rome, Italy. m.mangino@css-mendel.it
Salpietro
D C
DC
Zuccarello
D
D
Gangemi
S
S
Rigoli
L
L
Merlino
M V
MV
Briuglia
S
S
Bisignano
G
G
Mingarelli
R
R
Dallapiccola
B
B
D002178:Candidiasis, Chronic Mucocutaneous / Q000235:genetics*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics; D007558:Italy; D010375:Pedigree
D018799:Intercellular Adhesion Molecule-1