Hide and seek: the immunology of HSV persistence.
Herpes simplex virus (HSV) has been thought to persist as a latent infection by completely extinguishing antigen expression. In this issue of Immunity, Khanna et al. challenge this view by showing that CTL specific for antigens normally associated with active viral replication are crucial participants in regulating virus latency.
Carbone
Francis R
FR
Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia.
Speck
Peter G
PG
D000818:Animals; D006561:Herpes Simplex / Q000276:immunology*; D051379:Mice; D018139:Simplexvirus / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D017735:Virus Latency / Q000276:immunology*