Effects of uncoupling protein 1 and beta3-adrenergic receptor gene polymorphisms on body size and serum lipid concentrations in Japanese women.
OBJECTIVE
To investigate whether the -3826 A-G point mutation of the uncoupling protein 1 (UCP1) gene and the Trp64Arg mutation of the beta3-adrenergic receptor (beta3-AR) gene are associated with increased susceptibility to weight gain and hyperlipidemia in postmenopausal women.


METHODS
We genotyped 312 Japanese women for UCP1 and beta3-AR gene polymorphisms, and investigated their effects on anthropometrical parameters, serum lipid concentrations, and their changes after 4 years.


RESULTS
Although body mass index (BMI), serum triglyceride, total cholesterol, and low-density lipoprotein levels were significantly higher and high-density lipoprotein levels significantly lower in postmenopausal (n=182) than in premenopausal (n=99) women, there was no significant difference in these parameters between carriers and non-carriers of the G allele in the postmenopausal women. In the premenopausal women, BMI and the 4-year change in body weight (BW) of carriers of the G allele were significantly higher than those of non-carriers of the G allele (P=0.022 and 0.048, respectively). In the postmenopausal women, the 4-year change in the level of serum triglyceride of carriers of the G allele was significantly higher (P=0.049), and the change of high-density lipoprotein was significantly lower (P=0.020) than those of non-carriers of the G allele. The beta3-AR polymorphism showed no apparent affect on these parameters.


CONCLUSIONS
The -3826 A-G polymorphism of the UCP1 gene is associated with an increase in BW of premenopausal women and with the 4-year changes in serum triglyceride and high-density lipoprotein levels in postmenopausal women.
Matsushita
Hiroshi
H
Department of Obstetrics and Gynecology, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata 951-8510, Japan. matsuh@kf7.so-net.ne.jp.
Kurabayashi
Takumi
T
Tomita
Masatoshi
M
Kato
Nozomi
N
Tanaka
Kenichi
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015992:Body Mass Index; D002352:Carrier Proteins / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D007473:Ion Channels; D007564:Japan; D008565:Membrane Proteins / Q000235:genetics*; D008593:Menopause; D008875:Middle Aged; D024101:Mitochondrial Proteins; D009154:Mutation; D009765:Obesity / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D014280:Triglycerides / Q000097:blood; D000071256:Uncoupling Protein 1
D002352:Carrier Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D022702:Receptors, Adrenergic, beta-3; D014280:Triglycerides; C000604371:UCP1 protein, human; D000071256:Uncoupling Protein 1; D002784:Cholesterol