hOGG1 Ser326Cys polymorphism and breast cancer risk among Asian women.
To evaluate the potential association between breast cancer risk and Ser326Cys polymorphism of hOGG1 gene, encoding for an enzyme involved in the base excision repair of 8-hydroxyguanine, hospital based case-control studies were conducted in two Asian populations consisting of 475 breast cancer cases (271 Korean and 204 Japanese) and 500 controls (314 Korean and 186 Japanese). PCR-based methods were employed for the genotyping analyses and the statistical evaluations were performed by unconditional logistic regression model. The frequency of hOGG1 Ser/Ser, Ser/Cys, and Cys/Cys genotypes were 22.5, 48.7, and 28.8% in all cases, and 23.7, 52.1, and 24.1% in the controls. No statistically significant associations between the genotypes and breast cancer risk were observed, neither when the ethnic groups were examined separately nor when the total study population was included. Neither did stratification by menopausal status reveal any association between hOGG1 genotypes and breast cancer. Our novel findings therefore suggest that hOGG1 Ser326Cys polymorphism is unlikely to play a modifying role in individual susceptibility to breast cancer among Asian women.
Choi
Ji-Yeob
JY
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Hamajima
Nobuyuki
N
Tajima
Kazuo
K
Yoo
Keun-Young
KY
Yoon
Kyung-Sik
KS
Park
Sue Kyung
SK
Kim
Sook-Un
SU
Lee
Kyung-Mu
KM
Noh
Dong-Young
DY
Ahn
Se-Hyun
SH
Choe
Kuk-Jin
KJ
Han
Wonshik
W
Hirvonen
Ari
A
Kang
Daehee
D
D000328:Adult; D000368:Aged; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics*; D001943:Breast Neoplasms / Q000208:ethnology* / Q000235:genetics*; D016022:Case-Control Studies; D003545:Cysteine / Q000235:genetics; D045647:DNA Glycosylases / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007723:Korea / Q000453:epidemiology; D016015:Logistic Models; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012694:Serine / Q000235:genetics
D004273:DNA, Neoplasm; D012694:Serine; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human; D003545:Cysteine