[Primary gastric endocrine tumors].
OBJECTIVE
To study the clinicopathological features of gastric neuroendocrine tumors.


METHODS
Twenty cases were reviewed. The specimens were formalin-fixed, paraffin-embedded and immunostained by S-P method.


RESULTS
Among the twenty cases, one case was carcinoid, three were malignant carcinoids, six had small cell carcinomas and ten had mixed extocrine--endocrine carcinomas. Immunohistological examination of tumor cells found 80% positive for S-100, NSE (85%), CgA (50%), SY (50%), gastrin (30%), serotonin (65%), AE1/AE3 (50%), and CEA (80%).


CONCLUSIONS
In the WHO classification, there are five histological types in endocrine tumors of gastrointestinal tract. They are carcinoid, malignant carcinoid, small cell carcinoma, mixed exocrine--endocrine carcinoma and tumor-like lesions. But some cases in our paper were so different that they could not be classified. The gastric endocrine tumors are different from intestinal endocrine tumors and in classification, treatment and prognosis.
Liu
Shang-mei
SM
Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
Liu
Xiu-yun
XY
Zou
Shuang-mei
SM
Wei
Guo-lian
GL
Sun
Yun-tian
YT
D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D002276:Carcinoid Tumor / Q000378:metabolism / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005755:Gastrins / Q000378:metabolism; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D018358:Neuroendocrine Tumors / Q000378:metabolism / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*
D002272:Carcinoembryonic Antigen; D005755:Gastrins; D010751:Phosphopyruvate Hydratase