Structural framework for catalysis and regulation in ribulose-1,5-bisphosphate carboxylase/oxygenase.
Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the enzyme assimilating CO2 in biology. Despite serious efforts, using many different methods, a detailed understanding of activity and regulation in Rubisco still eludes us. New results in X-ray crystallography may provide a structural framework on which to base experimental approaches for more detailed analyses of the function of Rubisco at the molecular level. This article gives a critical review of the field and summarizes recent results from structural studies of Rubisco.
Andersson
Inger
I
Department of Molecular Biology, Swedish University of Agricultural Sciences, BMC Box 590, S-751 24, Uppsala, Sweden. inger@xray.bmc.uu.se <inger@xray.bmc.uu.se>
Taylor
Thomas C
TC
D001426:Bacterial Proteins / Q000737:chemistry; D001665:Binding Sites; D002245:Carbon Dioxide / Q000378:metabolism; D002384:Catalysis; D018360:Crystallography, X-Ray; D019992:Databases as Topic; D008024:Ligands; D008958:Models, Molecular; D011487:Protein Conformation; D012273:Ribulose-Bisphosphate Carboxylase / Q000737:chemistry* / Q000378:metabolism; D013696:Temperature
D001426:Bacterial Proteins; D008024:Ligands; D002245:Carbon Dioxide; D012273:Ribulose-Bisphosphate Carboxylase