What is the real role of antimicrobial polypeptides that can mediate several other inflammatory responses?
Antimicrobial peptides are effector molecules of innate immunity with microbicidal and pro- or anti-inflammatory activities. Their role is now widening following evidence that one such multifunctional peptide, LL-37, induces angiogenesis, a process essential for host defense, wound healing, and tissue repair.
Elsbach
Peter
P
Department of Medicine, New York University School of Medicine, New York, New York 10016, USA. elsbap01@mcrcr.med.nyu.edu
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology; D054804:Cathelicidins; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D010455:Peptides / Q000737:chemistry; D011355:Prodrugs / Q000494:pharmacology; D012259:Ribonuclease, Pancreatic / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D054804:Cathelicidins; D010455:Peptides; D011355:Prodrugs; C046366:angiogenin; D012259:Ribonuclease, Pancreatic