[Metalloproteinases and angiogenesis].
Metalloproteinases (MMPs) are essential regulators during various phases of the angiogenic process. These include the degradation of the basement membrane and the extracellular matrix, the mobilisation and activation of growth factors and the production of fragments with pro- or anti-angiogenic activity. In addition to their role in migration and invasion, MMPs can influence endothelial cell proliferation and survival by modifying the balance between angiogenic and anti-angiogenic molecules.
Gabison
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Unité 532 Inserm, Institut de recherche sur la peau, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
Hoang-Xuan
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Mauviel
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Menashi
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D000818:Animals; D001485:Basement Membrane; D002455:Cell Division; D002470:Cell Survival; D004730:Endothelium, Vascular / Q000166:cytology; D005109:Extracellular Matrix; D006801:Humans; D008666:Metalloendopeptidases / Q000378:metabolism*; D018919:Neovascularization, Physiologic
D008666:Metalloendopeptidases