Astrocytes as support for axonal regeneration in the central nervous system of mammals.
Reactive astrocytes are one of the main impediments for axonal regeneration in the central nervous system of mammals. Using mice KO for GFAP and vimentin, we show that reinnervation occurs after an hemisection of the spinal cord, mainly through sprouting of controlateral intact serotoninergic and cortico-spinal axons, thanks to the absence of glial reactivity. This reinnervation is paralleled by the restoration of impaired locomotion of the ipselateral hindleg. Future applications to spinal cord injured patients are discussed.
Privat
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Inserm U583, Montpellier, France.
D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000502:physiology*; D005904:Glial Fibrillary Acidic Protein / Q000172:deficiency / Q000235:genetics; D005911:Gliosis / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control*; D020439:Growth Cones / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D009416:Nerve Regeneration / Q000502:physiology*; D009434:Neural Pathways / Q000166:cytology / Q000254:growth & development; D020127:Recovery of Function / Q000235:genetics; D014746:Vimentin / Q000172:deficiency / Q000235:genetics
D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin