title: The use of linear programming in optimization of HDR implant dose distributions.
abstract: The introduction of high dose rate brachytherapy enabled optimization of dose distributions to be used on a routine basis. The objective of optimization is to homogenize the dose distribution within the implant while simultaneously satisfying dose constraints on certain points. This is accomplished by varying the time the source dwells at different locations. As the dose at any point is a linear function of the dwell times, a linear programming approach seems to be a natural choice. The dose constraints are inherently linear inequalities. Homogeneity requirements are linearized by minimizing the maximum deviation of the doses at points inside the implant from a prescribed dose. The revised simplex method was applied for the solution of this linear programming problem. In the homogenization process the possible source locations were chosen as optimization points. To avoid the problem of the singular value of the dose at a source location from the source itself we define the "self-contribution" as the dose at a small distance from the source. The effect of varying this distance is discussed. Test cases were optimized for planar, biplanar and cylindrical implants. A semi-irregular, fan-like implant with diverging needles was also investigated. Mean central dose calculation based on 3D Delaunay-triangulation of the source locations was used to evaluate the dose distributions. The optimization method resulted in homogeneous distributions (for brachytherapy). Additional dose constraints--when applied--were satisfied. The method is flexible enough to include other linear constraints such as the inclusion of the centroids of the Delaunay-triangulation for homogenization, or limiting the maximum allowable dwell time.
authors.affiliation: Department of Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA. jozef@hsc.usc.edu
authors.forename: Gabor
authors.initials: G
authors.lastname: Jozsef
authors.forename: Oscar E
authors.initials: OE
authors.lastname: Streeter
authors.forename: Melvin A
authors.initials: MA
authors.lastname: Astrahan
mesh_terms: D001918:Brachytherapy / Q000295:instrumentation* / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D011382:Programming, Linear; D011879:Radiotherapy Dosage; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D012062:Relative Biological Effectiveness