title: Molecular and biochemical analysis of the system regulating the lytic/lysogenic cycle in the pneumococcal temperate phage MM1.
abstract: The temperate phage MM1 forms stable lysogens in Streptococcus pneumoniae. We report here the first characterization of the lysogenic control region in Pneumococcus which contains two functional divergent promoters (P(R) and P(L)). MM1 encodes a 14-kDa cI protein (CI) that appears to be responsible for maintaining the lysogenic state in Pneumococcus since it prevents elongation of the transcripts controlled by P(R) and P(L).
authors.affiliation: Departamento de Microbiología Molecular, Centro de Investigaciones Biológicas, CSIC, Velázquez 144, 28006, Madrid, Spain.
authors.forename: Virginia
authors.initials: V
authors.lastname: Obregón
authors.forename: Pedro
authors.initials: P
authors.lastname: García
authors.forename: Rubens
authors.initials: R
authors.lastname: López
authors.forename: José L
authors.initials: JL
authors.lastname: García
mesh_terms: D001435:Bacteriophages / Q000235:genetics* / Q000254:growth & development; D004268:DNA-Binding Proteins; D015967:Gene Expression Regulation, Viral; D008242:Lysogeny / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics; D013296:Streptococcus pneumoniae / Q000737:chemistry* / Q000821:virology*; D014158:Transcription, Genetic / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics; D054334:Viral Regulatory and Accessory Proteins
chemical_list: D004268:DNA-Binding Proteins; D012097:Repressor Proteins; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; C016649:phage repressor proteins