title: Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.
authors.affiliation: Clemens Schöpf Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Petersenstrasse 22, Germany. schmibo@oc.chemie.tudarmstadt.de
authors.forename: Boris
authors.initials: B
authors.lastname: Schmidt
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schieffer
mesh_terms: D000179:Acrylates / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D000804:Angiotensin II / Q000378:metabolism*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D000959:Antihypertensive Agents / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D001562:Benzimidazoles / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D001713:Biphenyl Compounds / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D013006:Growth Hormone / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism; D007093:Imidazoles / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D000077405:Irbesartan; D019808:Losartan / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D008958:Models, Molecular; D044140:Receptor, Angiotensin, Type 1; D013777:Tetrazoles / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D013876:Thiophenes; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000179:Acrylates; D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D007093:Imidazoles; D044140:Receptor, Angiotensin, Type 1; D013777:Tetrazoles; D013876:Thiophenes; D000804:Angiotensin II; C068373:eprosartan; D013928:Thromboxane A2; D013006:Growth Hormone; D000077405:Irbesartan; D019808:Losartan; C081643:candesartan