CD4+ cell memory: the enigma of Th1 cells.
Despite a wealth of information pertaining to functional and phenotypic attributes of memory CD4(+) cells, the mechanisms that underlie the generation and persistence of memory in this subset are largely unknown. Recent work suggests that the development of memory might be differently regulated in T-helper-1 and T-helper-2 cells, owing to differences in their susceptibility to cell death. These studies support a new paradigm, in which memory T cells are heterogeneous in terms of their stage of maturation and function as well as mechanisms of homeostatic control.
Bradley
Linda M
LM
Division of Immunology, The Sidney Kimmel Cancer Center, 10 835 Altman Row, San Diego, CA 92121, USA. lbradley@skcc.org
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology* / Q000502:physiology