title: Complete remission induced by G-CSF in a patient with acute myeloid leukemia with t(8;21)(q22;q22).
abstract: We describe a case of acute myeloid leukemia (AML) with t(8;21) in which complete remission (CR) was obtained with G-CSF given at 10 microg/kg in the absence of concomitant cytotoxic chemotherapy. CR was achieved following 2 weeks of therapy and confirmed by investigating minimal residual disease by four-color flow cytometry analysis. During treatment with G-CSF, maturing cells with cytoplasmic Auer Rods were observed in the peripheral blood, suggesting a differentiation effect. This case adds further evidence for a specific role of G-CSF in the treatment of AML with t(8;21), namely in patients who are not eligible for aggressive chemotherapy.
authors.affiliation: Division of Hematology, Cardarelli General Hospital, Via Niccoló Piccinni 6, Naples 80128, Italy. felicettoferrara@katamail.com
authors.forename: Felicetto
authors.initials: F
authors.lastname: Ferrara
authors.forename: Ettore Mariano
authors.initials: EM
authors.lastname: Schiavone
authors.forename: Salvatore
authors.initials: S
authors.lastname: Palmieri
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Mele
authors.forename: Barbara
authors.initials: B
authors.lastname: Pocali
authors.forename: Giulia
authors.initials: G
authors.lastname: Scalia
authors.forename: Paolo
authors.initials: P
authors.lastname: Morabito
authors.forename: Lucia
authors.initials: L
authors.lastname: Sebastio
authors.forename: Luigi
authors.initials: L
authors.lastname: Del Vecchio
mesh_terms: D000208:Acute Disease; D001853:Bone Marrow / Q000473:pathology; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D005434:Flow Cytometry; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D016130:Immunophenotyping; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques; D012074:Remission Induction; D016879:Salvage Therapy; D014178:Translocation, Genetic; D016896:Treatment Outcome
chemical_list: D016179:Granulocyte Colony-Stimulating Factor