title: Radiofrequency ablation of hepatocellular carcinoma with a saline solution perfusion device: a pilot study.
abstract: OBJECTIVE
  The majority of patients with hepatocellular carcinoma (HCC) cannot be treated with surgery. This study evaluated the treatment of patients with radiofrequency ablation (RFA) with use of needle applicators perfused with isotonic saline solution.
  
  
  METHODS
  Twenty patients with a maximum of three HCCs as large as 60 mm and a contraindication to partial liver resection or orthotopic liver transplantation were enrolled in the study. They were treated with ultrasound-guided RFA with use of perfused needle applicators and followed with sonography and computed tomography.
  
  
  RESULTS
  Twenty patients (14 men, six women) with a total of 29 HCCs were treated with RFA. In total, 56 RFA treatments were performed. Mean HCC size was 31 mm (range, 10-60 mm). Two cases of self-limiting bleeding requiring transfusion of blood products took place. Complete response (CR) was achieved in 85% of patients (17 of 20). Partial response occurred in three tumors 45 mm in diameter or larger. There was a total of six local recurrences in five patients (25% of patients, 21% of tumors). Six patients (30%) exhibited distant recurrence, two of whom also showed local recurrence. In three patients, repeat treatment led to renewed CR. After a median follow-up of 445 days (range, 114-1,071 days), 12 patients (71% of the 17 patients with initial CR) still showed CR. Twelve patients (60% of all patients, 71% of those with initial CR) survived. Three of the eight patients who died were free of viable tumor at the time of death.
  
  
  CONCLUSIONS
  RFA with use of perfused needle applicators shows promise as an effective method for treating inoperable HCC. The most frequent complication was bleeding.
authors.affiliation: Department of Medicine I, Friedrich-Alexander University, Erlangen-Nuremberg, Germany. haensler@med1.imed.uni-erlangen.de
authors.forename: J
authors.initials: J
authors.lastname: Hänsler
authors.forename: M
authors.initials: M
authors.lastname: Frieser
authors.forename: S
authors.initials: S
authors.lastname: Schaber
authors.forename: C
authors.initials: C
authors.lastname: Kutschall
authors.forename: T
authors.initials: T
authors.lastname: Bernatik
authors.forename: W
authors.initials: W
authors.lastname: Müller
authors.forename: D
authors.initials: D
authors.lastname: Becker
authors.forename: E G
authors.initials: EG
authors.lastname: Hahn
authors.forename: D
authors.initials: D
authors.lastname: Strobel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000556:secondary / Q000601:surgery*; D017115:Catheter Ablation / Q000009:adverse effects / Q000295:instrumentation*; D005260:Female; D006801:Humans; D007552:Isotonic Solutions; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D019233:Retreatment; D012965:Sodium Chloride / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed; D018084:Ultrasonography, Interventional
chemical_list: D007552:Isotonic Solutions; D012965:Sodium Chloride