title: Gene expression of type I collagen in neoplastic chondrocytes.
abstract: In the present examination, we detected type I collagen mRNA in neoplastic chondrocytes in osteochondromas, typical benign bone neoplasms. We believe that the cells involved in >chondroid bone< appearing in osteochondromas temporally express cartilage phenotypes and then change directly into bone-forming cells that survive in the >chondroid bone< until the tissue is resorbed and remodelled into true bone tissue.
authors.affiliation: Department of Oral Pathology, Matsumoto Dental University, School of Dentistry, Shiojiri, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kimura
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kawakami
authors.forename: S
authors.initials: S
authors.lastname: Matsuura
authors.forename: H
authors.initials: H
authors.lastname: Hasegawa
authors.forename: H
authors.initials: H
authors.lastname: Kanda
authors.forename: H
authors.initials: H
authors.lastname: Tujigiwa
authors.forename: H
authors.initials: H
authors.lastname: Nagatsuka
authors.forename: N
authors.initials: N
authors.lastname: Nagai
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D019902:Chondrocytes / Q000378:metabolism / Q000473:pathology; D024042:Collagen Type I / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D015831:Osteochondroma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism
chemical_list: D024042:Collagen Type I; D012333:RNA, Messenger; D012334:RNA, Neoplasm