[A study of susceptibility genes mapping for aberrant B1 cell proliferation in New Zealand mice].
OBJECTIVE
To map the susceptibility genes for aberrant B1 cell proliferation in New Zealand mice.


METHODS
New Zealand Black (NZB) x New Zealand White (NZW) F1 x NZW backcross mice model was set up and polymorphic microsatellite markers and quantitative trait locus (QTL) analysis was used.


RESULTS
Susceptibility genes of aberrant B1 cell proliferation was linked to the microsatellite markers on chromosome 1, 4, 19 in NZB and on chromosome 17 in NZW such as D1Mit115, D4Mit58, D19Mit73 and D17Mit61 nearby which there existed Fcgr2b, c-jun, Fas and tumor necrosis factor (TNF)alpha, H-2 genes according to the QTL analysis.


CONCLUSIONS
B1 cell proliferation in New Zealand mice was controlled by multiple genes and the candidate susceptibility genes were Fcgr2b, c-jun, Fas derived from NZB strain and TNF alpha, H-2 genes derived from NZW strain.
Xiao
Wei-guo
WG
Department of Hematology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China. xonet5670@hotmail.com
He
Juan
J
Zhang
Li-jun
LJ
Li
Li
L
Chen
Yang
Y
Jiang
Yi
Y
D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D005260:Female; D020022:Genetic Predisposition to Disease; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D040641:Quantitative Trait Loci