Salmonella enterica serovar typhi strains isolated in Korea containing a multidrug resistance class 1 integron.
Six strains of Salmonella enterica serovar Typhi which were resistant to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, streptomycin, tetracycline, and gentamicin were isolated in Korea. This multidrug resistance was transferred by a conjugative plasmid of about 50 kb. The plasmid harbored a class 1 integron, which included six resistance genes, aacA4b, catB8, aadA1, dfrA1, aac(6')-IIa, and the novel blaP2, in that order. All of the isolates showed the same-size plasmids and the same ribotyping patterns, which suggests a clonal spread of these multidrug-resistant isolates.
Pai
Hyunjoo
H
Division of Infectious Disease, College of Medicine, Hanyang University, Seoul, Republic of Korea. paihj@unitel.co.kr
Byeon
Jeong-hum
JH
Yu
Sunmi
S
Lee
Bok Kwon
BK
Kim
Shukho
S
D003227:Conjugation, Genetic / Q000235:genetics; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D006801:Humans; D032023:Integrons / Q000235:genetics*; D007723:Korea; D016133:Polymerase Chain Reaction; D021521:Ribotyping; D012485:Salmonella typhi / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification*; D014435:Typhoid Fever / Q000382:microbiology*
D004269:DNA, Bacterial