Distribution of Nitric Oxide Synthase and Secretory Role of Exogenous Nitric Oxide in the Isolated Rat Pancreas.
Exocrine pancreatic secretion is controlled for themost part by the autonomic neurons and by I and Stype enteroendocrine cells (1). In addition to the classic neurotransmitters and various neuropeptides that are apparently produced and stored in the pancreaticnerve cells (2), there is morphological evidencethat nitric oxide (NO) containing (nitrergic) nervesare also present in the pancreas (3). Nitric oxide synthase(NOS) containing perikarya and fibers havebeen shown in the pancreas of several species usingenzymehistochemical and immunohistochemicalmethods (4). In the present study the nitrergic nervesof the rat pancreas were demonstrated by NOSimmunohistochemistry.
Ember
Zsolt
Z
Department of Anatomy, Faculty of Medicine, Semmelweis University, PO Box 95, 1450 Budapest, Hungary.
Yago
Maria
M
Singh
Jaipaul
J