[Hemodynamics and cell membrane effects of angiotensin II receptor antagonists in treatment of hypertension].
Strain on calcium-dependent mechanisms in essential hypertension (EH) is in activation of the calcium pump, structural-and-functional changes in Ca2+ ATPase and activation of proteinase C. In EH patients presenting with a high sensitivity to angiotensin II, there comes to be frequently seen an insufficient effectiveness of antagonists of receptors to angiotensin II.
Babadzhan
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VD
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000328:Adult; D000804:Angiotensin II / Q000097:blood; D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001792:Blood Platelets / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D019808:Losartan / Q000627:therapeutic use; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood
D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D008565:Membrane Proteins; D006852:Hydrochlorothiazide; D000804:Angiotensin II; D007703:Peptidyl-Dipeptidase A; D000251:Adenosine Triphosphatases; D019808:Losartan; D002118:Calcium