[Study on the association between squamous cell carcinoma of larynx and HPV subgene by PCR].
OBJECTIVE
To measure the human papilloma virus(HPV) HPV-E1 in squamous cell carcinoma of larynx.


METHODS
Polymerase chain reaction(PCR) was used to detect the HPV subgene in 25 specimens of laryngeal carcinoma and 6 normal larynges.


RESULTS
Positive expression of HPV-E1 was detected in 17 of 25 cases(68%) with squamous cell carcinoma and all the recurrent cases. However, there was no positive expression of HPV-E1 in the normal larynges (P < 0.01). The expression rate was not significantly different among the histological grad groups.


CONCLUSIONS
HPV-E1 infection was found in laryngeal carcinoma but not related to its histologic grading.
Wang
L
L
Department of Otorhinolaryngology, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510630.
Zhang
T
T
Zhang
F
F
D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000821:virology*; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D014412:Tumor Virus Infections / Q000821:virology*
D004279:DNA, Viral