title: Early recognition of neuroleptic malignant syndrome during traumatic brain injury rehabilitation.
abstract: Neuroleptic malignant syndrome is a rare disorder that manifests with hyperthermia, muscle rigidity and autonomic instability. Presented is a case series of individuals with traumatic brain injury and agitation who, when treated with neuroleptics, developed neuroleptic malignant syndrome. Although the incidence of this syndrome is rare, it is associated with significant morbidity and mortality. The onset of symptoms inconsistent with the patient's current level of recovery should alert the clinician to consider other possible diagnosis and failure to distinguish the features of neuroleptic malignant syndrome from post-traumatic agitation will delay appropriate intervention for this potentially life-threatening disorder.
authors.affiliation: Department of Physical Medicine and Rehabilitation, The Ohio State University Medical Center, Columbus, OH, USA. kadyan@osv.cdv
authors.forename: Vivek
authors.initials: V
authors.lastname: Kadyan
authors.forename: Sam C
authors.initials: SC
authors.lastname: Colachis
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Depalma
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Sanderson
authors.forename: W Jerry
authors.initials: WJ
authors.lastname: Mysiw
mesh_terms: D000328:Adult; D018726:Anti-Dyskinesia Agents / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000009:adverse effects; D001930:Brain Injuries / Q000150:complications / Q000534:rehabilitation*; D006220:Haloperidol / Q000009:adverse effects; D006801:Humans; D008297:Male; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis* / Q000209:etiology; D011595:Psychomotor Agitation / Q000188:drug therapy / Q000209:etiology
chemical_list: D018726:Anti-Dyskinesia Agents; D014150:Antipsychotic Agents; D006220:Haloperidol