[Expression and significance of interleukin-6,8 in human nasal polyps].
OBJECTIVE
To explore the role of interleukin-6,8 in nasal polyp formation and to search into the effect of allergy in the pathogenesis of nasal polyps (NP).


METHODS
The expression and significance of interleukin-6,8 were studied in 36 nasal polyps and 36 serum samples of NP patients by radioimmunoassay.


RESULTS
The mean value of IL-6 and IL-8 was (2.7658 +/- 0.3797) ng/L and (4.1877 +/- 0.1758) ng/L in all nasal polyp tissue homogenates. As compared with serum of NP patients, IL-6 and IL-8 were over expressed in nasal polyp tissue homogenates. No relation was found between the expression of IL-6/IL-8 and patients' gender, age and clinical stage. The expression of IL-6 and IL-8 in patients' serum, cord blood and normal serum showed no significant difference.


CONCLUSIONS
IL-6 and IL-8 are strongly correlated with the formation of nasal polyp. Neither allergy nor infection play a role in the pathogenesis of nasal polyps.
Liang
Y
Y
Department of Otorhinolaryngology, First Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China.
Lin
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000502:physiology; D016209:Interleukin-8 / Q000096:biosynthesis* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000209:etiology / Q000276:immunology / Q000378:metabolism*
D015850:Interleukin-6; D016209:Interleukin-8