title: [Study on the association between squamous cell carcinoma of larynx and HPV subgene by PCR].
abstract: OBJECTIVE
  To measure the human papilloma virus(HPV) HPV-E1 in squamous cell carcinoma of larynx.
  
  
  METHODS
  Polymerase chain reaction(PCR) was used to detect the HPV subgene in 25 specimens of laryngeal carcinoma and 6 normal larynges.
  
  
  RESULTS
  Positive expression of HPV-E1 was detected in 17 of 25 cases(68%) with squamous cell carcinoma and all the recurrent cases. However, there was no positive expression of HPV-E1 in the normal larynges (P < 0.01). The expression rate was not significantly different among the histological grad groups.
  
  
  CONCLUSIONS
  HPV-E1 infection was found in laryngeal carcinoma but not related to its histologic grading.
authors.affiliation: Department of Otorhinolaryngology, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510630.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: T
authors.initials: T
authors.lastname: Zhang
authors.forename: F
authors.initials: F
authors.lastname: Zhang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000821:virology*; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D014412:Tumor Virus Infections / Q000821:virology*
chemical_list: D004279:DNA, Viral