Acute management of seizures in the syndromes of idiopathic generalized epilepsies.
Three of the seizure types (myoclonic, absence, and generalized tonic-clonic) and syndromes associated with idiopathic generalized or genetic epilepsies can present an acute status epilepticus picture that requires acute therapy. These are not the usual seizures observed in status epilepticus because most of these patients have secondary generalized or symptomatic generalized convulsive seizures. In this review, I discuss the unique presentation and treatment options for the acute management of seizures in the syndromes of idiopathic generalized epilepsy (IGE), with special emphasis on the seizures of status epilepticus, which persist over time or occur in a series without recovery of consciousness.
Wheless
James W
JW
Texas Comprehensive Epilepsy Program, Department of Neurology and Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas 77030, U.S.A. james.w.wheless@uth.tmc.edu
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D002998:Clonazepam / Q000627:therapeutic use; D015897:Comorbidity; D004334:Drug Administration Schedule; D004831:Epilepsies, Myoclonic / Q000188:drug therapy / Q000453:epidemiology; D004832:Epilepsy, Absence / Q000188:drug therapy / Q000453:epidemiology; D004829:Epilepsy, Generalized / Q000188:drug therapy* / Q000453:epidemiology; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D007262:Infusions, Intravenous; D008140:Lorazepam / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D013226:Status Epilepticus / Q000188:drug therapy / Q000453:epidemiology; D013577:Syndrome; D014635:Valproic Acid / Q000008:administration & dosage / Q000627:therapeutic use
D000927:Anticonvulsants; D002998:Clonazepam; D014635:Valproic Acid; D008140:Lorazepam