[Expression and significance of clusterin in normal prostate, benign prostate hyperplasia and prostate cancer].
OBJECTIVE
To investigate the expression and significance of Clusterin in normal prostate, benign prostate hyperplasia (BPH) and prostate cancer.


METHODS
Clusterin expression in samples of 12 normal prostate, 15 BPH, and 56 prostate cancer were studied by immunohistochemical stain.


RESULTS
Of 83 cases, 67 are positive or weak positive (81%). The rate of positive or weak positive for normal prostate, BPH and prostate cancer was 17% (2/12), 73% (11/15), and 96% (54/56) respectively. The expression level of Clusterin in prostate cancer was much higher than in normal prostate (t = 8.82, P < 0.01). BPH (t = 7.63, P < 0.01) was related positively with pathological grade (r = 0.649, P < 0.01) and stage (r = 0.609, P < 0.01) of prostate cancer.


CONCLUSIONS
Clusterin may play an important role in the biological characteristics of prostate cancer by the anti-apoptosis pathway.
Zhou
Li-qun
LQ
Institute of Urology, First Hospital, Peking University, Beijing 100034, China.
Yang
Xue-zhen
XZ
Zeng
Li
L
Liang
Li-li
LL
Yang
Xin-yu
XY
Ren
Liang
L
Chung
Lee
L
Zhang
Zhi-wen
ZW
Na
Yan-qun
YQ
Gu
Fang-liu
FL
Guo
Ying-lu
YL
D017209:Apoptosis; D051152:Clusterin / Q000378:metabolism* / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology
D051152:Clusterin