title: Chromosomal abnormalities in inflammatory pseudotumor of the urinary bladder.
abstract: Inflammatory pseudotumors of the urinary bladder are rare, benign, nonepithelial tumors. Fewer than 30 have been reported, and no data are available on their karyotypic characteristics and/or the molecular mechanisms of pathogenesis. We performed short-term culturing and cytogenetic analysis of an inflammatory pseudotumor of the bladder, finding a der(20)t(12;20)(q13 approximately q15;q13) as the only cytogenetic aberration. The detection of a 12q13 approximately q15 rearrangement in the inflammatory pseudotumor indicates that this lesion is pathogenetically related to other benign mesenchymal tumors displaying, for example, lipogenic or leiomyomatous differentiation, something that is in sharp contrast to the karyotypic profile of epithelial tumors of the urinary bladder mucosa.
authors.affiliation: Department of Surgical Urology, Faculty of Medicine, Upper Nile University, Upper Nile State, Sudan.
authors.forename: Imad
authors.initials: I
authors.lastname: Fadl-Elmula
authors.forename: Ludmila
authors.initials: L
authors.lastname: Gorunova
authors.forename: Nils
authors.initials: N
authors.lastname: Mandahl
authors.forename: Sverre
authors.initials: S
authors.lastname: Heim
mesh_terms: D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics; D006104:Granuloma, Plasma Cell / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000235:genetics*