title: Risk factors for piperacillin/tazobactam-resistant Escherichia coli in ICU patients: a clinical study.
abstract: OBJECTIVE
  To determine risk factors of infections with piperacillin/tazobactam-resistant Escherichia coli in critical care patients.
  
  
  METHODS
  Prospective, consecutive sample survey study.
  
  
  METHODS
  Surgical intensive care unit (ICU) in a university hospital.
  
  
  METHODS
  A consecutive series of 133 patients from whom culture results were positive for E. coli during their ICU stay.
  
  
  METHODS
  None.
  
  
  RESULTS
  Multivariate logistic regression analysis identified the following significant independent factors associated with the emergence of a piperacillin/tazobactam-resistant Escherichia coli: prior use of amoxicillin (odds ratio, 4.15) and amoxicillin/clavulanate (odds ratio, 3.25).
  
  
  CONCLUSIONS
  Treatment with amoxicillin or amoxicillin/clavulanate is a major risk factor for the detection of piperacillin/tazobactam-resistant E. coli in ICU patients.
authors.affiliation: Intensive Care Unit, Edouard Herriot Hospital, Claude Bernard University, 69003, Lyon, France. ismael.mohammedi@chu-lyon.fr
authors.forename: Ismaël
authors.initials: I
authors.lastname: Mohammedi
authors.forename: Dominique
authors.initials: D
authors.lastname: Ploin
authors.forename: Serge
authors.initials: S
authors.lastname: Duperret
authors.forename: François
authors.initials: F
authors.lastname: Chapuis
authors.forename: Paul
authors.initials: P
authors.lastname: Petit
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D005602:France; D006801:Humans; D007362:Intensive Care Units; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010878:Piperacillin / Q000494:pharmacology*; D011446:Prospective Studies; D012307:Risk Factors; D000078142:Tazobactam
chemical_list: D000900:Anti-Bacterial Agents; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin