Haemolysin A and listeriolysin--two vaccine delivery tools for the induction of cell-mediated immunity.
Haemolysin A of Escherichia coli and listeriolysin of Listeria monocytogenes represent important bacterial virulence factors. While such cytolysins are usually the reason for morbidity and even mortality, vaccine researchers have turned haemolysin A and listeriolysin into tools for vaccine delivery. Both cytolysins have found widespread application in vaccine research and are highly suitable for the elicitation of cell-mediated immunity. In this paper, we will review vaccine delivery mediated by the haemolysin A secretion system and listeriolysin and will highlight their use in vaccination approaches against protozoan parasites.
Dietrich
Guido
G
Vaccine Research, Berna Biotech AG, Rehhagstr. 79, CH-3018, Bern, Switzerland. guido.dietrich@bernabiotech.com
Viret
Jean-Francois
JF
Gentschev
Ivaylo
I
D000941:Antigens / Q000276:immunology; D000981:Antiprotozoal Agents / Q000276:immunology; D001427:Bacterial Toxins / Q000276:immunology; D016503:Drug Delivery Systems; D029968:Escherichia coli Proteins / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology*; D006460:Hemolysin Proteins / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D008089:Listeria monocytogenes / Q000276:immunology; D011528:Protozoan Infections / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination / Q000379:methods; D014613:Vaccines, Attenuated / Q000008:administration & dosage* / Q000276:immunology
D000941:Antigens; D000981:Antiprotozoal Agents; D001427:Bacterial Toxins; D029968:Escherichia coli Proteins; D006360:Heat-Shock Proteins; D006460:Hemolysin Proteins; C036507:Hlya protein, E coli; D014613:Vaccines, Attenuated; C038705:hlyA protein, Listeria monocytogenes