Osteopontin polymorphisms and disease course in multiple sclerosis.
Osteopontin (OPN), also known as early T-cell activating gene (Eta-1), has been recently shown to be a critical factor in the progression of experimental autoimmune encephalomyelitis, and perhaps multiple sclerosis (MS). Here we investigated whether the 327T/C, 795C/T, 1128A/G or 1284A/C single-nucleotide polymorphisms in the OPN gene were correlated with susceptibility or any of the several clinical end points in a cohort of 821 MS patients. Overall, we observed no evidence of genetic association between the OPN polymorphisms and MS. Although not reaching statistical significance, a modest trend for association with disease course was detected in patients carrying at least one wild-type 1284A allele, suggesting an effect on disease course. Patients with this genotype were less likely to have a mild disease course and were at increased risk for a secondary-progressive clinical type.
Caillier
S
S
Department of Neurology, University of California, San Francisco, CA 43143-0435, USA.
Barcellos
L F
LF
Baranzini
S E
SE
Swerdlin
A
A
Lincoln
R R
RR
Steinman
L
L
Martin
E
E
Haines
J L
JL
Pericak-Vance
M
M
Hauser
S L
SL
Oksenberg
J R
JR
D000328:Adult; D000483:Alleles; D016001:Confidence Intervals; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics* / Q000503:physiopathology; D020528:Multiple Sclerosis, Chronic Progressive / Q000235:genetics / Q000503:physiopathology; D016017:Odds Ratio; D053495:Osteopontin; D011110:Polymorphism, Genetic / Q000235:genetics*; D012795:Sialoglycoproteins / Q000235:genetics*
C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D053495:Osteopontin