title: Acetylenic acids from the aerial parts of Nanodea muscosa.
abstract: The aerial parts of Nanodea muscosa, collected in Chile, yielded two new acetylenic acids. Their structures were elucidated by spectroscopic analyses, including 2D NMR techniques, as (13E)-octadec-13-en-11-ynoic acid (1) and (2E)-octadec-2-en-4-ynedioic acid (2). Compound 2 constitutes the first example of a conjugated ene-yne fatty diacid isolated from a natural source. Compounds 1 and 2 did not exhibit toxicity toward a panel of DNA damage checkpoint defective yeast mutants or show affinity for the 5-HT(1A), 5-HT(2A), D(2), and H(1) receptors.
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González-González, Avenida Astrofísico Fco. Sánchez No. 2, La Laguna, 38206 Tenerife, Spain.
authors.forename: N
authors.initials: N
authors.lastname: El-Jaber
authors.forename: A
authors.initials: A
authors.lastname: Estévez-Braun
authors.forename: A G
authors.initials: AG
authors.lastname: Ravelo
authors.forename: O
authors.initials: O
authors.lastname: Muñoz-Muñoz
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez-Afonso
authors.forename: J R
authors.initials: JR
authors.lastname: Murguia
mesh_terms: D000480:Alkynes; D002677:Chile; D004249:DNA Damage / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2 / Q000187:drug effects; D011969:Receptors, Histamine H1 / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D044263:Receptors, Serotonin, 5-HT1; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D029630:Santalaceae / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D005231:Fatty Acids, Unsaturated; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2; D011969:Receptors, Histamine H1; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; C031203:2-hexadecynoic acid