Effect of ketoprofen, lidocaine local anesthesia, and combined xylazine and lidocaine caudal epidural anesthesia during castration of beef cattle on stress responses, immunity, growth, and behavior.
To determine the effects of burdizzo castration alone or in combination with ketoprofen (K), local anesthesia (LA), or caudal epidural anesthesia (EPI) on plasma cortisol, acute-phase proteins, interferon-gamma production, growth, and behavior of beef cattle, 50 Holstein x Friesian bulls (13 mo old, 307 +/- 5.3 kg) were assigned to (n = 10/treatment): 1) control (handled; C); 2) burdizzo castration (B); 3) B following K (3 mg/ kg of BW i.v.; BK); 4) B following LA (8 mL into each testis and 3 mL s.c. along the line where the jaws of the burdizzo were applied with 2% lidocaine HCl; BLA); and 5) B following EPI (0.05 mg/kg of BW of xylazine HCl and 0.4 mg/kg of BW of lidocaine HCl as caudal epidural; BEPI). The area under the cortisol curve against time was lower (P < 0.05) in BK than in B, BLA, or BEPI animals. On d 1 after treatment, plasma haptoglobin concentrations were higher (P < 0.05) in B, BLA, and BEPI than in BK animals. On d 3, haptoglobin and plasma fibrinogen concentrations were higher (P < 0.05) in all castration groups than in C. On d 7, haptoglobin and fibrinogen concentrations remained higher (P < 0.05) in BLA than in B and C animals. On d 1, concanavalin A-induced interferon-gamma production was lower (P < 0.05) in B, BLA, and BEPI than in C, but there was no difference between BK and C animals. From d -1 to 35, ADG was lower (P < 0.05) in B, BLA, and BEPI animals, but not in BK compared with C animals. Overall, there was a higher (P < 0.05) incidence of combined abnormal postures in B than in C, BK and BEPI animals. Although the use of K and EPI decreased (P < 0.05) these postures compared with B alone or B with LA, there was no difference between the K and EPI treatment. In conclusion, burdizzo castration increased plasma cortisol and acute-phase proteins, and suppressed immune function and growth rates. Local anesthesia prolonged the increase in acute-phase proteins. Ketoprofen was more effective than LA or EPI in decreasing cortisol and partially reversed the reduction in ADG following castration. The use of K or EPI was more effective than LA in decreasing pain-associated behavioral responses observed during the first 6 h after treatment. Systemic analgesia with ketoprofen, a non-steroidal antiinflammatory drug, was more effective in reducing inflammatory responses associated with castration than LA or EPI.
Ting
S T L
ST
Teagasc, Grange Research Centre, Dunsany, Co. Meath, Ireland.
Earley
B
B
Hughes
J M L
JM
Crowe
M A
MA
D000209:Acute-Phase Proteins / Q000032:analysis / Q000378:metabolism; D000210:Acute-Phase Reaction / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary; D000763:Anesthesia, Caudal / Q000662:veterinary; D000772:Anesthesia, Local / Q000662:veterinary; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002417:Cattle / Q000254:growth & development / Q000276:immunology / Q000502:physiology* / Q000601:surgery; D006854:Hydrocortisone / Q000097:blood; D007371:Interferon-gamma / Q000096:biosynthesis; D007660:Ketoprofen / Q000494:pharmacology*; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D009919:Orchiectomy / Q000662:veterinary*; D011897:Random Allocation; D013312:Stress, Physiological / Q000517:prevention & control / Q000662:veterinary; D014991:Xylazine / Q000494:pharmacology*
D000209:Acute-Phase Proteins; D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014991:Xylazine; D007371:Interferon-gamma; D007660:Ketoprofen; D008012:Lidocaine; D006854:Hydrocortisone