title: Enantiomeric separation of acidic compounds of pharmaceutical interest by capillary electrochromatography employing glycopeptide antibiotic stationary phases.
abstract: Enantiomeric separation of some selected acidic compounds of pharmaceutical interest belonging to the group of non-steroidal anti-inflammatory drugs were separated by capillary electrochromatography employing silica based glycopeptide antibiotic stationary phases, namely vancomycin or a teicoplanin derivatives (Hepta-Tyr). The vancomycin stationary phase allowed to achieve the chiral resolution of some racemic studied compounds only using mobile phases containing ammonium formate at a relatively low pH 2.5-3.5 and acetonitrile. Employing the teicoplanin derivative stationary phase, good enantiomeric resolution was achieved eluting with mobile phases containing sodium phosphate pH 6-acetonitrile. Enantiomers were moved to the detector because a relatively high reversed electroosmotic flow (due to the positive charge of the stationary phase) and to the electrophoretic mobility of analytes.
authors.affiliation: Istituto di Metodologie Chimiche, CNR, Area della Ricerca di Roma, P.O. Box 10, 00016 Monterotondo Scalo, Rome, Italy. fanali@imc.cnr.it
authors.forename: Salvatore
authors.initials: S
authors.lastname: Fanali
authors.forename: Paolo
authors.initials: P
authors.lastname: Catarcini
authors.forename: Carla
authors.initials: C
authors.lastname: Presutti
mesh_terms: D000143:Acids; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D006020:Glycopeptides; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000143:Acids; D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D004364:Pharmaceutical Preparations