Haematuria and urolithiasis in patients with haemophilia.
Recurrent haematuria was present in 18 of 474 moderate and severe haemophiliacs, the cause of which was found to be urolithiasis in six patients (33%). The prevalence of urolithiasis in haemophiliacs was found to be significantly higher than that reported from the general population, i.e. 4.5 of 10 000 population under 40 yr of age (odds ratio (OR) 23.4; 95% CI 18.2-28.7; lambda2 test P < 0.01). Even when this prevalence was corrected for gender bias, i.e. male : female (5 : 1), the significance of the present findings remain (OR 17.6; 95% CI 13.8-21.5; lambda2 test P < 0.01). In developing countries, severe and moderately severe haemophiliacs may be at a higher risk of urolithiasis because of prolonged recumbency necessitated by recurrent joint bleeds and inadequate replacement therapy.
Ghosh
Kanjaksha
K
Institute of Immunohaematology, Indian Council of Medical Research, KEM Hospital Campus, Parel, Mumbai, India. kanjakshaghosh@hotmail.com
Jijina
Farah
F
Mohanty
Dipika
D
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006417:Hematuria / Q000453:epidemiology / Q000209:etiology*; D006467:Hemophilia A / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012189:Retrospective Studies; D014545:Urinary Calculi / Q000150:complications / Q000453:epidemiology / Q000209:etiology*