Ca2+-dependent signaling pathways in the heart: potential drug targets for cardiac disease.
Ca2+ is an important secondary messenger and any alteration to intracellular Ca2+ signaling pathways or components of these pathways can have a profound physiological effect on any cell, particularly cardiomyocytes. Early approaches to investigate heart disease focused on many muscle proteins, however recent findings indicate that molecules considered as "non-muscle" proteins may be equally important players in etiology of many cardiac pathologies. Many of these "non-muscle" proteins play a role in Ca2+ cycling or Ca2+ -dependent signaling pathways in the heart. In this review we focus on Ca2+ -dependent pathways in normal, growing, and diseased hearts. Understanding of these unique signaling pathways may hold answers to many cardiac pathologies in children and adults.
Lynch
Jeffrey
J
Membrane Proteins Research Group, Canadian Institutes of Health, Edmonton, Alberta, Canada T6G 2H7.
Michalak
Marek
M
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D016503:Drug Delivery Systems / Q000379:methods*; D006321:Heart / Q000502:physiology*; D006331:Heart Diseases / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans