Impact of stem cell donation modality on normal donor quality of life: a prospective randomized study.
As part of a previously reported trial comparing granulocyte-colony stimulating factor (G-CSF) stimulated bone marrow and peripheral blood stem cells (PBSCs) in allogeneic stem cell transplantation, we included a questionnaire to compare donor morbidity and long-term complications between the two donation procedures. Bone marrow donation was associated with significantly more donors experiencing localized pain at the donation site compared to PBSC collection. However, this was not associated with any increased delay in returning to normal activity. Although a minority of bone marrow donors suffered chronic pain at the donation site, no serious long-term side effects relating to G-CSF stimulated stem cell donation were identified.
Kennedy
G A
GA
Department of Haematology, Royal Brisbane Hospital, Brisbane, Australia.
Morton
J
J
Western
R
R
Butler
J
J
Daly
J
J
Durrant
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D019650:Hematopoietic Stem Cell Mobilization / Q000523:psychology / Q000706:statistics & numerical data*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D019520:Living Donors / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011994:Recombinant Proteins; D033581:Stem Cell Transplantation / Q000379:methods* / Q000523:psychology; D011795:Surveys and Questionnaires; D013997:Time Factors
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor