title: Excessive daytime sleepiness and levodopa in Parkinson's disease: polygraphic, placebo-controlled monitoring.
abstract: The authors performed 72-hour polysomnography, including a levodopa-placebo-controlled choice reaction time test with continuous monitoring of cardiovascular variables in two patients with Parkinson's disease complaining of excessive daytime sleepiness on levodopa monotherapy. The subacute levodopa challenge was accompanied by physiologic sleep episodes, worsened reaction times, and a reduction in mean blood pressure and heart rate over baseline values, linked temporally to the sleep episodes.
authors.affiliation: Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy. contin@neuro.unibo.it
authors.forename: Manuela
authors.initials: M
authors.lastname: Contin
authors.forename: Federica
authors.initials: F
authors.lastname: Provini
authors.forename: Paolo
authors.initials: P
authors.lastname: Martinelli
authors.forename: Roberto
authors.initials: R
authors.lastname: Riva
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Albani
authors.forename: Roberto
authors.initials: R
authors.lastname: Vetrugno
authors.forename: Caterina
authors.initials: C
authors.lastname: Lombardi
authors.forename: Pasquale
authors.initials: P
authors.lastname: Montagna
authors.forename: Agostino
authors.initials: A
authors.lastname: Baruzzi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D006970:Disorders of Excessive Somnolence / Q000139:chemically induced*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007980:Levodopa / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy*; D017286:Polysomnography; D011930:Reaction Time / Q000187:drug effects; D012890:Sleep / Q000187:drug effects
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa