title: Malondialdehyde in benign prostate hypertrophy: a useful marker?
abstract: Benign prostate hypertrophy (BPH) is the most common benign tumor in men due to obstruction of the urethra and, finally, uremia. Malondialdehyde (MDA) is a product derived from peroxidation of polyunsaturated fatty acids and related esters. Evaluation of MDA in serum represents a non-invasive biomarker of oxidative stress. Prostate-specific antigen (PSA) is a sensitive marker for prostatic hypertrophy and cancer. We analyzed MDA serum levels to evaluate the oxidative stress in BPH. To this end, 22 BPH patients and 22 healthy donors were enrolled. Data show an increase of MDA level in BPH patients and a positive correlation between PSA and MDA levels. In conclusion, we describe a previously unknown relationship between PSA and MDA as an index of inflammation and oxidative stress in BPH.
authors.affiliation: Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Italy.
authors.forename: Rosaria Alba
authors.initials: RA
authors.lastname: Merendino
authors.forename: Francesco
authors.initials: F
authors.lastname: Salvo
authors.forename: Antonella
authors.initials: A
authors.lastname: Saija
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Pasquale
authors.forename: Antonio
authors.initials: A
authors.lastname: Tomaino
authors.forename: Paola Lucia
authors.initials: PL
authors.lastname: Minciullo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Fraccica
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Gangemi
mesh_terms: D000368:Aged; D015415:Biomarkers; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde; D017430:Prostate-Specific Antigen