Serum concentration of type IV collagen 7S domain as a marker for increased risk of recurrence after liver resection for hepatocellular carcinoma.
OBJECTIVE
Serum concentration of type IV collagen 7S domain (7S collagen) is a marker of hepatic fibrosis. We investigated the usefulness of measuring the serum 7S collagen concentration as a risk factor for recurrence after liver resection for hepatocellular carcinoma (HCC).


METHODS
The serum 7S collagen concentration was measured before liver resection for HCC in 219 patients. Group 1 included 102 patients with a high serum concentration of 7S collagen (>or=8.0 ng/ml), and group 2 consisted of 117 patients with a low serum concentration of 7S collagen (<8.0 ng/ml). Clinicopathologic findings and outcome after surgery were compared between groups.


RESULTS
The results of liver function tests were better in group 2 than in group 1. The percentage of patients with cirrhosis or who underwent minor resection was higher in group 1 than in group 2. The percentage of patients with moderately or poorly differentiated HCC or portal invasion was higher in group 2 than in group 1. Univariate and multivariate analyses identified that a high serum concentration of 7S collagen (>or=8.0 ng/ml) was an independent risk factor for recurrence.


CONCLUSIONS
Measuring the serum 7S collagen concentration is useful to estimate the risk of recurrence after resection of HCC.
Kawai
Shuichi
S
Second Department of Surgery, Osaka City University Medical School, Osaka, Japan. m3181871@msic.med.osaka-cu.ac.jp
Kubo
Shoji
S
Tsukamoto
Tadashi
T
Tanaka
Hiromu
H
Shuto
Taichi
T
Yamamoto
Takatsugu
T
Hirohashi
Kazuhiro
K
Kinoshita
Hiroaki
H
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000601:surgery*; D024141:Collagen Type IV / Q000097:blood*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012307:Risk Factors
D014408:Biomarkers, Tumor; D024141:Collagen Type IV