Fluoroquinolone use and Clostridium difficile-associated diarrhea.
We performed a case-control study to evaluate the association between antibiotic use and Clostridium difficile-associated diarrhea (CDAD), matching for admission unit and time at risk for CDAD. A multivariable regression model showed that treatment with fluoroquinolones (odds ratio 12.7; 95% confidence interval 2.6 to 61.6) was the strongest risk factor for CDAD.
McCusker
Margaret E
ME
University of Maryland, Baltimore, Maryland, USA.
Harris
Anthony D
AD
Perencevich
Eli
E
Roghmann
Mary-Claire
MC
D000368:Aged; D016022:Case-Control Studies; D016360:Clostridioides difficile / Q000302:isolation & purification; D003015:Clostridium Infections / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D003428:Cross Infection / Q000453:epidemiology; D003967:Diarrhea / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology*; D005260:Female; D024841:Fluoroquinolones / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors
D024841:Fluoroquinolones