E1AF expression levels are not associated with prognosis in human breast cancer.
E1AF is a transcription factor involved in regulation of several metastasis-associated genes, and is associated with overexpression of HER2/neu. We were unable to find a clear prognostic value of E1AF expression in human breast cancer. Furthermore, no association of E1AF levels with HER2/neu mRNA levels, hormone receptor status, histological grade, tumor size, or lymph node involvement was found.
Span
Paul N
PN
Department of Chemical Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands. p.span@ace.umcn.nl
Manders
Peggy
P
Heuvel
Joop J T M
JJ
Beex
Louk V A M
LV
Sweep
C G J
CG
D017500:Adenovirus E1A Proteins / Q000378:metabolism*; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism* / Q000556:secondary; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D050783:Proto-Oncogene Proteins c-ets; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D020893:Receptor, ErbB-3 / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism; D012189:Retrospective Studies; D014157:Transcription Factors / Q000378:metabolism*
D017500:Adenovirus E1A Proteins; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D018719:Erb-b2 Receptor Tyrosine Kinases; D020893:Receptor, ErbB-3; D011987:Receptors, Steroid; D014157:Transcription Factors; C079853:ETV4 protein, human