title: Very severe aplastic anemia appearing after thymectomy.
abstract: Aplastic anemia is a rare complication of thymoma and is extremely infrequent after thymectomy. We present a case of a 60-year-old woman with very severe aplastic anemia appearing sixteen months after thymectomy for a thymoma. She underwent thymectomy for a thymoma in April 2000. Preoperative examination revealed no hematologic abnormality. About sixteen months after the operation, she was readmitted because of pancytopenia with cough and fever. Bone marrow aspiration revealed a very severe hypoplasia in all the three cell lines with over 80% fatty tissue, and chest CT revealed no recurrence of thymoma. Her aplastic anemia had responded to cyclosporine A and granulocyte-colony stimulating factor (G-CSF).
authors.affiliation: Catholic Hemopoietic Stem Cell Transplantation Center, Catholic University College of Medicine, Seoul, Korea.
authors.forename: Chi Young
authors.initials: CY
authors.lastname: Park
authors.forename: Hee Je
authors.initials: HJ
authors.lastname: Kim
authors.forename: Yoo Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Yoon Hee
authors.initials: YH
authors.lastname: Park
authors.forename: Jong Wook
authors.initials: JW
authors.lastname: Lee
authors.forename: Woo Sung
authors.initials: WS
authors.lastname: Min
authors.forename: Chun Choo
authors.initials: CC
authors.lastname: Kim
mesh_terms: D000741:Anemia, Aplastic / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D016572:Cyclosporine / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D035583:Rare Diseases; D018570:Risk Assessment; D012720:Severity of Illness Index; D013934:Thymectomy / Q000009:adverse effects* / Q000379:methods; D013945:Thymoma / Q000175:diagnosis / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D016572:Cyclosporine