Deep brain stimulation for the treatment of Parkinson's disease: the experience of the Neurosurgical Department in Monza.
deep brain stimulation is a widely accepted surgical therapy for the symptomatic treatment of advanced parkinson's disease; high frequency chronic stimulation of the subthalamic nucleus proved its efficacy to control the major motor symptoms. In the neurosurgical department of Monza we treated 72 parkinsonian patients (November 1998-January 2003). One year follow-up results are: decrease of tremor 90%, hypertonous 56%, bradykinesia 70%, voice impairment amelioration 30%, mean total daily L-dopa intake reduced 58%. Freezing and balance did not ameliorate, some voice impairment and psychic derangement have been observed. Major surgical complications were: haemorrage (1 case - transient hemiparesis), infections (2 cases), pulmonary embolisation (1 case). To optimise the surgical results, careful clinical and instrumental selection of the patients are mandatory before surgery.
Landi
A
A
Clinica Neurochirurgica, Università degli Studi di Milano, Bicocca, Ospedale San Gerardo, Monza, Italy.
Parolin
M
M
Piolti
R
R
Antonini
A
A
Grimaldi
M
M
Crespi
M
M
Iurlaro
S
S
Aliprandi
A
A
Pezzoli
G
G
Ferrarese
C
C
Gaini
S M
SM
D002986:Clinical Trials as Topic / Q000379:methods; D004599:Electric Stimulation Therapy / Q000379:methods*; D004567:Electrodes, Implanted; D006801:Humans; D007558:Italy; D010300:Parkinson Disease / Q000628:therapy*; D018579:Patient Selection; D011182:Postoperative Care; D020531:Subthalamic Nucleus / Q000503:physiopathology* / Q000601:surgery; D016896:Treatment Outcome