title: [Effectiveness of flunarizine in the prophylaxis of migraine: a meta-analytical review of the literature].
abstract: BACKGROUND
  Migraine is a common and disabling health problem among young and middle aged adults. Flunarizine have been used as a prophylactic medication in its management for more than two decades.
  
  
  OBJECTIVE
  The aim of the study is to systematically review the evidence obtained from randomized controlled trials about the efficacy and security of flunarizine versus placebo for the prevention of migraine in adults.
  
  
  METHODS
  Electronic search were performed using the databases MEDLINE, EMBASE, Biosis, the Cochrane Library, Lilacs and others. Reference lists of retrieved studies, reviews and conference abstracts were used to found another articles. Additionally, the authors performed a handsearched in recognized journals related to migraine and neurological topics. Randomized, placebo controlled, double blind trials assessing the efficacy of flunarizine for preventing migraine were included. We evaluated the frequency of the attacks by comparing the mean frequency before and after the intervention for each group of treatment and then the two groups were compared. To evaluate the security of flunarizine we used included and excluded studies and open trials.
  
  
  RESULTS
  Nine studies were obtained but only four met the inclusion criteria. The fixed effects model reported a reduction in the frequency of attacks by using flunarizine. The monthly difference was 0.55 attacks (CI 95%= 0.215 0.895; p= 0.002). Somnolence was the most frequent adverse effect in 20.5% of the subjects (n= 1,987).
  
  
  CONCLUSIONS
  Based on a small number of trials, flunarizine, at a daily dose of 10 mg lightly reduces the frequency of migraine attacks.
authors.affiliation: Servicio de Medicina Familiar, Instituto Nacional de Cancerología, Pontificia Universidad Javeriana, Bogotá, Colombia. mmreveiz@hotmail.com
authors.forename: L
authors.initials: L
authors.lastname: Reveiz-Herault
authors.forename: A F
authors.initials: AF
authors.lastname: Cardona
authors.forename: E G
authors.initials: EG
authors.lastname: Ospina
authors.forename: P
authors.initials: P
authors.lastname: Carrillo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D005444:Flunarizine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000517:prevention & control*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D005444:Flunarizine