title: Biocompatibility study of polymeric biomaterials.
abstract: Polymeric hydrogels are used as wound dressing material since these materials show advantages such as pain relief, exudates absorption, barrier to microorganisms, permeability, and others. This article shows the results obtained in a study aiming to know the biological performance of different polymeric materials to be used in contact with skin: PVP hydrogels and acrylate adhesive. The biocompatibility was determined by in vitro assay of cytotoxicity and in vivo assay by using the contact test of irritability in rabbits. All the tested samples presented no toxicity and no dermal irritation.
authors.affiliation: Instituto de Pesquisas Energéticas e Nucleares, Cidade Universitária, São Paulo, Brazil. sorogero@net.ipen.br
authors.forename: Sizue O
authors.initials: SO
authors.lastname: Rogero
authors.forename: Sônia M
authors.initials: SM
authors.lastname: Malmonge
authors.forename: Ademar B
authors.initials: AB
authors.lastname: Lugão
authors.forename: Tamiko I
authors.initials: TI
authors.lastname: Ikeda
authors.forename: Lígia
authors.initials: L
authors.lastname: Miyamaru
authors.forename: Aurea S
authors.initials: AS
authors.lastname: Cruz
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000633:toxicity*; D020100:Hydrogels / Q000138:chemical synthesis / Q000633:toxicity*; D011108:Polymers / Q000138:chemical synthesis / Q000633:toxicity*; D011817:Rabbits; D012867:Skin / Q000187:drug effects*
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D011108:Polymers