[Streptomycetes--producers of polyketide antibiotics].
The review is dedicated to biosynthesis of polyketides compounds by streptomycetes. It contains new data about structure of streptomycete chromosome, structure and action mechanism of polyketidesynthases of I and II types and gene clusters determining the biosynthesis of polyketides. A new promising approach is considered--the combinatorial biosynthesis of hybrid "unnatural" antibiotics by means of gene engineering construction of recombinant strains bearing the biosynthetic genes of bacterial aromatic polyketidesynthases.
Matseliukh
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Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154 Zabolotny St., Kyiv, 03143, Ukraine.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000138:chemical synthesis* / Q000737:chemistry; D002876:Chromosomes, Bacterial / Q000235:genetics; D020650:Combinatorial Chemistry Techniques; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism*; D011995:Recombination, Genetic; D013302:Streptomyces / Q000201:enzymology* / Q000235:genetics* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D007659:Ketones; D009097:Multienzyme Complexes