title: [Roles of CD43, CD20 and local IgE in the pathogenesis of nasal polyps].
abstract: OBJECTIVE
  To estimate the roles of CD43, CD20 and total IgE in the pathogenesis of nasal polyps.
  
  
  METHODS
  Twenty-six cases of nasal polyps and 20 cases of mucosa of middle turbinates were used in present study.
  
  
  RESULTS
  The number of CD43+ cells, CD20+ cells and plasma cells in nasal polyps were significantly more than that in middle turbinates (P < 0.01). The positive rate of local IgE+ cells in nasal polyps was significantly higher than in middle turbinate (P < 0.01).
  
  
  CONCLUSIONS
  There were active cellular immunity and humoral immunity in nasal polyps. Local allergy may play a role in the pathogenesis of nasal polyps.
authors.affiliation: Beijing Institute of Otorhinolaryngology, Beijing 100005, China. wangxiangdong88@sina.com
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Guo
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Tao
authors.forename: D
authors.initials: D
authors.lastname: Han
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.forename: E
authors.initials: E
authors.lastname: Fan
authors.forename: Y
authors.initials: Y
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD; D018951:Antigens, CD20 / Q000096:biosynthesis / Q000502:physiology*; D002648:Child; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000276:immunology; D051917:Leukosialin; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000209:etiology* / Q000276:immunology; D012795:Sialoglycoproteins / Q000096:biosynthesis / Q000502:physiology*
chemical_list: D015703:Antigens, CD; D018951:Antigens, CD20; D051917:Leukosialin; C465014:SPN protein, human; D012795:Sialoglycoproteins; D007073:Immunoglobulin E