title: [Clopidogrel: background information and use in clinical practice].
abstract: Acute manifestations of atherosclerosis, e.g. myocardial infarction and ischaemic stroke, are among the most common causes of death in the western part of the world. Rupture of an atherosclerotic plaque results in activation, adhesion and aggregation of platelets. Antithrombotic treatment has shown to reduce mortality and morbidity and is used in both primary and secondary prevention. The thienopyridine Clopidogrel specifically and irreversibly inhibits the binding of ADP to platelet surface ADP-receptors, thereby inhibiting platelet activation and aggregation. In this publication the pharmacological background and clinical documentation for the use of Clopidogrel both as monotherapy and in combination with Acetylicsalisylic acid are reviewed.
authors.affiliation: Arhus Universitetshospital, Arhus Amtssygehus, Klinisk Farmakologisk Afdeling, Aalborg Sygehus, Kardiologisk Afdeling.
authors.forename: Birgitte Klindt
authors.initials: BK
authors.lastname: Ziegler
authors.forename: Lars Hvilsted
authors.initials: LH
authors.lastname: Rasmussen
authors.forename: Steen Dalby
authors.initials: SD
authors.lastname: Kristensen
authors.forename: Per Rossen
authors.initials: PR
authors.lastname: Hildebrandt
authors.forename: Hans Kraemmer
authors.initials: HK
authors.lastname: Nielsen
authors.forename: Steen E
authors.initials: SE
authors.lastname: Husted
mesh_terms: D001161:Arteriosclerosis / Q000150:complications / Q000188:drug therapy*; D001241:Aspirin / Q000008:administration & dosage; D000077144:Clopidogrel; D003324:Coronary Artery Disease / Q000150:complications / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006801:Humans; D009203:Myocardial Infarction / Q000209:etiology / Q000517:prevention & control; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D058919:Purinergic P2 Receptor Antagonists; D020521:Stroke / Q000209:etiology / Q000517:prevention & control; D013927:Thrombosis / Q000150:complications / Q000188:drug therapy*; D013988:Ticlopidine / Q000008:administration & dosage* / Q000031:analogs & derivatives
chemical_list: D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D058919:Purinergic P2 Receptor Antagonists; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin