Mitochondrial toxicity and lactic acidosis.
Mitochondrial toxicity and one of its symptoms called lactic acidosis have been highlighted recently as a previously undiagnosed side effect of anti-HIV drugs. Some researchers believe that mitochondrial toxicity contributes to the fat redistribution (lipodystrophy) associated with anti-HIV therapy. Although much more research is needed to fully understand this issue, this article explores the current thoughts about the connections among mitochondrial toxicity, lactic acidosis and lipodystrophy.
D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000503:physiopathology; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005234:Fatty Liver / Q000139:chemically induced; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008060:Lipodystrophy / Q000139:chemically induced; D008928:Mitochondria / Q000187:drug effects*
D019380:Anti-HIV Agents