title: A new prognostic model for testicular germ cell tumours.
abstract: In univariate analyses of patients with metastatic testicular germ cell tumours (TGCT), both the International Germ Cell Consensus Classification (IGCCC) and serum lactate dehydrogenase (S-LD) isoenzyme 1 catalytic concentration (S-LD-1) significantly predicted survival. In complementary analyses of 81 patients with metastatic TGCT, S-LD and S-LD-1 classified the prognosis differently for 23 patients. In multivariate Cox hazard analyses of risk factors, only IGCCC and S-LD-1 predicted the prognosis (p=0.036, and p=0.0007, respectively). A new prognostic model based on prognostic information from main histology, IGCCC, and S-LD-1 changed the prognostic prediction by IGCCC for 19 patients (24%). Judged by to the area under the curve for receiver operation characteristics curves, the new model predicted five-years survival for the patients better than IGCCC and a modified version of the third edition of the TNM classification (p=0.025, and p=0.01, respectively). However, new studies should validate the new model before it is recommended as a general classification system of patients with metastatic TGCT.
authors.affiliation: Center of Tobacco Research, Odense, Department of Oncology, Soenderborg Hospital, Denmark. feve@post5.tele.dk
authors.forename: Finn Edler
authors.initials: FE
authors.lastname: von Eyben
authors.forename: Ebbe Lindegaard
authors.initials: EL
authors.lastname: Madsen
authors.forename: Herbert
authors.initials: H
authors.lastname: Fritsche
authors.forename: Gabriel
authors.initials: G
authors.lastname: Suciu
authors.forename: Frank
authors.initials: F
authors.lastname: Liu
authors.forename: Robert
authors.initials: R
authors.lastname: Amato
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D018237:Germinoma / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D016609:Neoplasms, Second Primary / Q000097:blood / Q000175:diagnosis*; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis; D013736:Testicular Neoplasms / Q000097:blood / Q000175:diagnosis*; D013737:Testis / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase