title: Acne and hirsuties in teenagers.
abstract: Acne and body hair are both cutaneous responses to androgenic stimulation. They are normal events in adolescent girls. There is considerable variation in the evolution of the two conditions. The sebaceous gland is exquisitely sensitive to androgens, and acne appears with the onset of puberty, peaks in prevalence in the teenage years and gradually improves thereafter. Hair growth on the face, trunk and limbs develops more slowly and generally peaks in the 20s. Indications for endocrine investigation include very severe acne, onset of acne and hirsuties in the very early stage of puberty (Tanner stage 3) and systemic virilism. Treatment for acne and hirsuties can be either topical or systemic. The choice of therapy is based on the severity of the disease rather than the results of endocrine investigation. Further, since PCO is related to impaired glucose tolerance, advice relating to lifestyle changes should be offered to prevent the development of diabetes.
authors.affiliation: Department of Clinical Biochemistry and Immunology & Leeds Foundation for Dermatological Research, Leeds Teaching Hospital, NHS Trust, Leeds General Infirmary, Leeds, LS1 3EX, UK. j.h.barth@leeds.ac.uk
authors.forename: Julian H
authors.initials: JH
authors.lastname: Barth
authors.forename: Sheila
authors.initials: S
authors.lastname: Clark
mesh_terms: D000152:Acne Vulgaris / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D000293:Adolescent; D004700:Endocrine System Diseases / Q000150:complications / Q000175:diagnosis; D005260:Female; D006197:Hair / Q000254:growth & development; D006628:Hirsutism / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008297:Male