title: The antiplatelet aggregation effects of aspirin suppositories.
abstract: To confirm that aspirin suppositories are an effective treatment for acute ischemic stroke, we examined the suppressive effects of 200-mg aspirin suppositories on platelet aggregation. Aspirin suppositories suppressed platelet aggregation induced by ADP or collagen, and the suppression continued for 24 h. There was no significant difference in suppression of platelet aggregation between aspirin administered by suppository and orally given aspirin. These results suggest that aspirin suppositories are a useful treatment for acute ischemic stroke.
authors.affiliation: Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayasu
authors.forename: Masanobu
authors.initials: M
authors.lastname: Maeda
authors.forename: Takao
authors.initials: T
authors.lastname: Soda
authors.forename: Kenji
authors.initials: K
authors.lastname: Iijima
authors.forename: Manabu
authors.initials: M
authors.lastname: Ishimoto
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ieiri
authors.forename: Fumie
authors.initials: F
authors.lastname: Tabuchi
authors.forename: Kenji
authors.initials: K
authors.lastname: Otsubo
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakashima
mesh_terms: D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000328:Adult; D001241:Aspirin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003094:Collagen / Q000037:antagonists & inhibitors / Q000494:pharmacology; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012727:Sex Characteristics; D013488:Suppositories
chemical_list: D010975:Platelet Aggregation Inhibitors; D013488:Suppositories; D000244:Adenosine Diphosphate; D003094:Collagen; D001241:Aspirin