Very severe aplastic anemia appearing after thymectomy.
Aplastic anemia is a rare complication of thymoma and is extremely infrequent after thymectomy. We present a case of a 60-year-old woman with very severe aplastic anemia appearing sixteen months after thymectomy for a thymoma. She underwent thymectomy for a thymoma in April 2000. Preoperative examination revealed no hematologic abnormality. About sixteen months after the operation, she was readmitted because of pancytopenia with cough and fever. Bone marrow aspiration revealed a very severe hypoplasia in all the three cell lines with over 80% fatty tissue, and chest CT revealed no recurrence of thymoma. Her aplastic anemia had responded to cyclosporine A and granulocyte-colony stimulating factor (G-CSF).
Park
Chi Young
CY
Catholic Hemopoietic Stem Cell Transplantation Center, Catholic University College of Medicine, Seoul, Korea.
Kim
Hee Je
HJ
Kim
Yoo Jin
YJ
Park
Yoon Hee
YH
Lee
Jong Wook
JW
Min
Woo Sung
WS
Kim
Chun Choo
CC
D000741:Anemia, Aplastic / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D016572:Cyclosporine / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D035583:Rare Diseases; D018570:Risk Assessment; D012720:Severity of Illness Index; D013934:Thymectomy / Q000009:adverse effects* / Q000379:methods; D013945:Thymoma / Q000175:diagnosis / Q000601:surgery*; D016896:Treatment Outcome
D016179:Granulocyte Colony-Stimulating Factor; D016572:Cyclosporine