Randomized controlled trials in psychiatry. Part 1: methodology and critical evaluation.
OBJECTIVE
To introduce clinicians to the methodology and critical appraisal of randomized controlled trials (RCTs) in psychiatry.


METHODS
The methodology of RCTs in psychiatry is discussed. Using a systematic approach to critical appraisal, a published RCT of treatments for severe depression is examined and evaluated.


CONCLUSIONS
The RCT appraised illustrates certain problematic areas in the methodology of trials in psychiatry. A detailed knowledge of methodology and critique of RCTs is essential in determining whether reported results will influence clinicians' practice.
Porter
Richard
R
Department of Psychological Medicine, Christchurch School of Medicine, PO Box 4345, Christchurch 8001, New Zealand. richard.porter@chmeds.ac.nz
Frampton
Chris
C
Joyce
Peter R
PR
Mulder
Roger T
RT
D003511:Cyclohexanols / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy / Q000523:psychology*; D004311:Double-Blind Method; D006801:Humans; D018579:Patient Selection; D011570:Psychiatry / Q000379:methods*; D016032:Randomized Controlled Trials as Topic / Q000592:standards*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D000069470:Venlafaxine Hydrochloride
D003511:Cyclohexanols; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride