title: Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.
abstract: Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t(1/2) = 44 months) that eradication is unlikely.
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205 USA.
authors.forename: Janet D
authors.initials: JD
authors.lastname: Siliciano
authors.forename: Joleen
authors.initials: J
authors.lastname: Kajdas
authors.forename: Diana
authors.initials: D
authors.lastname: Finzi
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Quinn
authors.forename: Karen
authors.initials: K
authors.lastname: Chadwick
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Margolick
authors.forename: Colin
authors.initials: C
authors.lastname: Kovacs
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Gange
authors.forename: Robert F
authors.initials: RF
authors.lastname: Siliciano
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000821:virology*; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D012367:RNA, Viral / Q000097:blood; D013997:Time Factors; D014766:Viremia; D017735:Virus Latency
chemical_list: D012367:RNA, Viral