N(2)O stimulates NOS enzyme activity in C57BL/6 but not DBA/2 mice.
Exposure to 70% N(2)O produces a prominent antinociception in C57BL/6 mice but not DBA/2 mice. N(2)O exposure also increases conversion of [14C]L-arginine to [14C]L-citrulline in homogenates prepared from whole brains of C57BL/6 mice; there was no such increase in NOS activity in the DBA/2 whole brain. A differential N(2)O effect on brain NOS in these inbred strains might explain why the C57BL/6 but not DBA/2 mice are responsive to N(2)O antinociception.
Ishikawa
Masago
M
Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA, USA.
Quock
Raymond M
RM
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D009609:Nitrous Oxide / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects; D013045:Species Specificity
D018712:Analgesics, Non-Narcotic; D019001:Nitric Oxide Synthase; D009609:Nitrous Oxide