[Effect of Rg2 on hemodynamics of hemorrhagic shock and its antioxidation in dogs].
OBJECTIVE
To investigate the protective effect of Rg2 on hemodynamics of hemorrhagic shock and its antioxidant properties.


METHODS
Twenty mongrel dogs were randomly divided into Rg2 group, Shen Mai group and control group. The hemorrhagic shock model was built in all dogs by artery bleeding and mean arterial blood pressure was kept < 5.33 kPa for 4.5 hours. Rg2 0.5-1.0 mg.kg-1 and Shen Mai 100 mg.kg-1 were intravenously administered after hemorrhagic shock appeared.


RESULTS
Rg2 significantly enhanced blood pressure, LVSP and +/- dp/dtmax on hemorrhagic shock dogs who had lost compensation ability. Rg2 0.5-1.0 mg.kg-1 could reduce serum MDA, increase superoxide dismutase activity and prolong survival rate of dogs after shock. All these data have statistically significant when compared to control group (P < 0.05, P < 0.01, P < 0.001).


CONCLUSIONS
These results suggest that Rg2 is more potent and effective than Shen Mai in improving hemodynamic state and activiting SOD on hemorrhagic shock dogs.
Lu
J
J
Norman Bethune University of Medical Sciences, Changchun 130021, Jilin, China.
Lu
W W
WW
Tian
J M
JM
Li
L Y
LY
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D036145:Ginsenosides / Q000302:isolation & purification / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D005894:Panax / Q000737:chemistry*; D011897:Random Allocation; D012771:Shock, Hemorrhagic / Q000097:blood / Q000503:physiopathology*; D013482:Superoxide Dismutase / Q000097:blood; D015996:Survival Rate
D000975:Antioxidants; D036145:Ginsenosides; D008315:Malondialdehyde; C026474:ginsenoside Rg2; D013482:Superoxide Dismutase