[In vivo and in vitro evaluation of inflow cannula of left ventricular assist].
OBJECTIVE
To develop an inflow cannula of left ventricular assist implanted by blood vessel.


METHODS
The maximum inflow and properties against folding of 8 sorts of cannulae were measured in mimic extracorporeal circulation appliances and canines.


RESULTS
The maximum flow of the cannula increased, as the inner diameter became greater (P < 0.01) compared with each group. The maximum flow rate was (1.82 +/- 0.03) L/min, (2.44 +/- 0.03) L/min, (3.02 +/- 0.04) L/min, (3.31 +/- 0.03) L/min respectively for polyvinyl cannulae with wall thickness of 0.5 mm (PV 0.5 cannula) and inner diameter of 3 mm, 4 mm, 5 mm, 6 mm; (1.83 +/- 0.03) L/min, (3.07 +/- 0.04) L/min respectively for the polyvinyl chloride cannula with wall thickness of 1.0 mm imbedded by spring wire (PVCSW 1.0) and inner diameter of 3 mm and 5 mm; (1.82 +/- 0.02) L/min, 1.84 +/- 0.02 L/min for strengthened polyvinyl cannula with wall thickness of 0.8 mm (SPV 0.8) and inner diameter of 3 mm and polyvinyl cannula with wall thickness of 1.0 mm (PV 1.0 cannula) of inner diameter of 3 mm. There was no remarked statistical difference in vitro maximum flow among the four cannulae of 3 mm inner diameter in vitro. PVCSW 1.0 was showed the best antifolding property, PV 1.0 cannula good and SPV 0.8 and PV 0.5 unsatisfactory in properties against fold. There was no significant statistical difference between in vivo and in vitro maximum flow for PVCSW 1.0 and PV 1.0 cannulae of 3 mm inner diameter. But for SPV 0.8 and PV 0.5 cannulae of 3 mm inner diameter, there was a significant difference between in vivo and in vitro.


CONCLUSIONS
PV 0.5 cannula and SPV 0.8 cannula are not suitable to clinical use. PV 1.0 cannula can be used in clinics. PVCSW 1.0 cannula is fully qualified for inflow conduit of left ventricular assist in surgery.
Tong
Lian-wei
LW
Department of Cardiothoracic Surgery, Guangzhou Red Cross Hopsital, Medical College of Ji'nan University, Guangzhou 510220, China.
Ren
Bing
B
Zhu
Xiao-dong
XD
D000818:Animals; D002404:Catheterization; D004285:Dogs; D006353:Heart-Assist Devices