Type 2 diabetes presenting as diabetic ketoacidosis in adolescence.
We report two black adolescent subjects who presented with diabetic ketoacidosis, but who lacked autoimmune markers and demonstrated clinical and biochemical characteristics more typical of Type 2 diabetes, including obesity, acanthosis nigricans, positive family history for Type 2 diabetes, and Type 2 diabetic dyslipidaemia. Subsequent to acute presentation, insulin was discontinued in both subjects and excellent glycaemic control was achieved with metformin therapy alone. Four months following acute presentation, both had adequate C-peptide responses to intravenous glucagon. Type 2 diabetes can present as diabetic ketoacidosis in obese adolescent subjects.
Valabhji
J
J
Department of Endocrinology and Metabolic Medicine, St Mary's Hospital, London, UK. j.valabhji@ic.ac.uk
Watson
M
M
Cox
J
J
Poulter
C
C
Elwig
C
C
Elkeles
R S
RS
D000052:Acanthosis Nigricans / Q000150:complications*; D000293:Adolescent; D001786:Blood Glucose; D001835:Body Weight; D002096:C-Peptide / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology*; D016883:Diabetic Ketoacidosis / Q000097:blood / Q000208:ethnology / Q000209:etiology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D007333:Insulin Resistance; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D009765:Obesity / Q000209:etiology
D001786:Blood Glucose; D002096:C-Peptide; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D008687:Metformin