title: Endovascular treatment of experimentally induced aneurysms in rabbits using stents: a feasibility study.
abstract: Although Guglielmi detachable coil (GDC) systems have been generally accepted for treatment of intracranial aneurysms, primary stenting of aneurysms using porous stents or implantation of coils after stent placement remains experimental. Testing of these new methods requires an animal model which imitates human aneurysms in size, configuration and neck morphology. We assessed in detail the technical requirements of and steps for transfemoral stent treatment of experimentally induced aneurysms at the top of the brachiocephalic trunk in rabbits. We created aneurysms in ten rabbits by distal ligation and intraluminal digestion of the right common carotid artery with elastase. We treated five animals with porous stents alone, and five with stents plus coiling via the meshes of the stent, which permitted dense packing of coils. No complications related to the procedures occurred. In all animals, even in those treated solely with porous stents, total occlusion of the aneurysm was achieved. Our animal model can be suitable for testing the biocompatibility and occlusion rate of new methods and devices for the treatment of experimental aneurysms.
authors.affiliation: Department of Neurosurgery, University Hospital of the University of Technology, Pauwelsstrasse 30, 52057, Aachen, Germany.
authors.forename: F J
authors.initials: FJ
authors.lastname: Hans
authors.forename: T
authors.initials: T
authors.lastname: Krings
authors.forename: W
authors.initials: W
authors.lastname: Möller-Hartmann
authors.forename: R
authors.initials: R
authors.lastname: Thiex
authors.forename: J
authors.initials: J
authors.lastname: Pfeffer
authors.forename: K
authors.initials: K
authors.lastname: Scherer
authors.forename: A
authors.initials: A
authors.lastname: Brunn
authors.forename: H
authors.initials: H
authors.lastname: Dreeskamp
authors.forename: K P
authors.initials: KP
authors.lastname: Stein
authors.forename: A
authors.initials: A
authors.lastname: Meetz
authors.forename: J M
authors.initials: JM
authors.lastname: Gilsbach
authors.forename: A
authors.initials: A
authors.lastname: Thron
mesh_terms: D000783:Aneurysm / Q000628:therapy*; D015901:Angiography, Digital Subtraction / Q000379:methods; D000818:Animals; D017536:Carotid Artery, Common; D002343:Carotid Artery, Internal; D004195:Disease Models, Animal; D004621:Embolization, Therapeutic; D005240:Feasibility Studies; D019736:Prostheses and Implants; D011817:Rabbits; D015607:Stents