[Spontaneous leukosis as a model for an investigation of low and very low physical and physico-chemical effects on oncological process].
Kinetic investigation of spontaneous leukosis in AKR mice have been carried in connection with a number of indices: changes in the mass of principal organs of the immune systems (thymus, spleen, lymphatic nodes), liver, alterations of haematological data (the sum of leukocytes, the percentage composition of blood cells, the quantity of undifferentiated cells), changes of physico-chemical conditions in cells (NMR-investigation). The dynamics of some of these indices and also life-spans of animals with leukosis after irradiation with doses 1.2-2.4 cGy (dose-rate 0.6 cGy/day) have been investigated. The enhancement of the frequency of leukosis and shortening the average and maximum life-spans of irradiated mice has been found.
Erokhin
V N
VN
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119991 Russia.
Burlakova
E B
EB
D000818:Animals; D005260:Female; D005720:Gamma Rays; D007942:Leukemia, Experimental / Q000097:blood / Q000276:immunology / Q000401:mortality; D007953:Leukemia, Radiation-Induced / Q000097:blood / Q000276:immunology / Q000401:mortality; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008806:Mice, Inbred AKR; D008962:Models, Theoretical; D011829:Radiation Dosage; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D013997:Time Factors