Microbial hydroxylation of progesterone with Acremonium strictum.
Microbial hydroxylation of progesterone occurred in the culture of Acremonium strictum PTCC 5282 to produce two hydroxylated pregnene-like steroids. The metabolites were purified and characterized using spectroscopic methods and identified as 15alpha-hydroxyprogesterone and 15alpha-hydroxydeoxycorticosterone.
Faramarzi
Mohammad Ali
MA
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, 14174, Tehran, Iran.
Tabatabaei Yazdi
Mojtaba
M
Amini
Mohsen
M
Zarrini
Gholamreza
G
Shafiee
Abbas
A
D000164:Acremonium / Q000378:metabolism*; D001711:Biotransformation; D006889:Hydroxycorticosteroids / Q000737:chemistry / Q000378:metabolism; D006900:Hydroxylation; D006908:Hydroxyprogesterones / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D011374:Progesterone / Q000737:chemistry / Q000378:metabolism*
D006889:Hydroxycorticosteroids; D006908:Hydroxyprogesterones; D011374:Progesterone