[Effect of components of dang-gui-bu-xue decoction on hematopenia].
OBJECTIVE
To investigate the effects and the related mechanisms of the components of Dang-Gui-Bu-Xue decoction (DGBXD) on improving blood deficiency.


METHODS
The effects of promoting hematopoietic function were observed with the blood difficient model mice, by giving components of DGBXD. RBC, WBC, reticulocytes and bone marrow nucleated cells (BMNC) were determined. The components of DGBXD on proliferation of BMNC and on clony forming unit (CFU) were also determined.


RESULTS
The components of DGBXD remarkably increased the quantity of RBC, WBC, and BMNC. Some of the components promoted the proliferation of BMNC and increased the quantity of CFU-Mix. Among them, polysaccharide of angelica was most potent.


CONCLUSIONS
The studies show that the extracts and some components of DGBXD can promote the hemopoietic function system of the model mice, and they exert the effects in a comprehensive way.
Ning
Lian
L
Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. lioning@teacher.com
Chen
Chang-xun
CX
Jin
Ruo-min
RM
Wu
Yao-ping
YP
Zhang
Hai-gui
HG
Sun
Cheng-li
CL
Song
Chun-qing
CQ
Hu
Zhi-bi
ZB
D029971:Angelica sinensis / Q000737:chemistry*; D000818:Animals; D027885:Astragalus propinquus / Q000737:chemistry*; D001772:Blood Cell Count; D001854:Bone Marrow Cells / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D011134:Polysaccharides; C477279:danggui buxue decoction; C044613:angelicae sinensis extract