The role of p53 in the immunobiology of cutaneous squamous cell carcinoma.
Cutaneous squamous cell carcinoma is typically characterized by the over-expression of the tumour suppressor protein p53. Considerable evidence suggests that immune competence is important in the control of cutaneous SCC. We discuss the immunobiology of p53 and its relevance to cutaneous SCC, including the potential interaction with human papillomavirus.
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University of Oxford, MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, The John Radcliffe Hospital, UK.
Ogg
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D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000821:virology; D006801:Humans; D007121:Immunocompetence; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications; D012878:Skin Neoplasms / Q000276:immunology* / Q000821:virology; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*; D014412:Tumor Virus Infections / Q000150:complications
D016159:Tumor Suppressor Protein p53