Intermittent microinjection method in freely-moving rats and its application to neuropharmacology.
Intermittent delivery of drugs into a discrete brain region has proven to be a useful technique. Described here is a micro-pump injection unit with miniature step-motors. This injection system is reliable, easy to operate and inexpensive to construct. The application of intermittent injection systems to study reward neurochemical circuits is discussed.
Ikemoto
Satoshi
S
Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA. sikemoto@intra.nida.nih.gov
D000818:Animals; D008845:Microinjections / Q000295:instrumentation / Q000379:methods*; D051381:Rats; D012054:Reinforcement, Psychology; D012201:Reward