Fatal acute granulomatous pulmonary aspergillosis in a healthy subject after inhalation of vegetal dust.
A previously healthy 28-year-old man presented a few hours after inhalation of vegetal dust with acute bilateral community-acquired pneumonia, which caused death in 10 days despite treatment with broad-spectrum antibiotics, intravenous amphotericin B, inotropic support, and mechanical ventilation. A postmortem lung biopsy indicated miliary granulomatous pulmonary aspergillosis. Six similar previously published cases of acute granulomatous pulmonary aspergillosis are reviewed. This entity in adulthood may reveal a defect in neutrophil or macrophage function, such as late-onset chronic granulomatous disease.
Batard
E
E
Service des Urgences, Centre Hospitalier Universitaire, Nantes, France.
Renaudin
K
K
Morin
O
O
Desjars
P
P
Germaud
P
P
D000208:Acute Disease; D000328:Adult; D000900:Anti-Bacterial Agents; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000188:drug therapy / Q000473:pathology*; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D001707:Biopsy, Needle; D018450:Disease Progression; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D004391:Dust; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D018570:Risk Assessment; D012720:Severity of Illness Index
D000900:Anti-Bacterial Agents; D004391:Dust