Caveolae/raft-dependent endocytosis.
Although caveolae are well-characterized subdomains of glycolipid rafts, their distinctive morphology and association with caveolins has led to their internalization being considered different from that of rafts. In this review, we propose that caveolae and rafts are internalized via a common pathway, caveolae/raft-dependent endocytosis, defined by its clathrin independence, dynamin dependence, and sensitivity to cholesterol depletion. The regulatory role of caveolin-1 and ligand sorting in this complex endocytic pathway are specifically addressed.
Nabi
Ivan R
IR
Département de Pathologie et Biologie Cellulaire, Université de Montréal, C.P. 6128, Succursale A, Montréal, Québec, Canada H3C 3J7. ivan.robert.nabi@umontreal.ca
Le
Phuong U
PU
D000818:Animals; D021941:Caveolae / Q000378:metabolism*; D051242:Caveolin 1; D022461:Caveolins / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D022162:Cytoplasmic Vesicles / Q000378:metabolism; D004705:Endocytosis; D021962:Membrane Microdomains / Q000378:metabolism*
D051242:Caveolin 1; D022461:Caveolins; D002784:Cholesterol