title: New insights into a persistent problem -- chlamydial infections.
abstract: Tissue tropism of clinical ocular and genital Chlamydia trachomatis strains is shown to be linked to the tryptophan synthase genotype. It is suggested that, in the presence of IFN-gamma, which depletes available tryptophan, there exist unique host-parasite interactions that may contribute to persistent chlamydial infection.
authors.affiliation: Department of Microbiology, Montana State University, Bozeman, Montana 59717, USA. morrison@montana.edu
authors.forename: Richard P
authors.initials: RP
authors.lastname: Morrison
mesh_terms: D002690:Chlamydia Infections / Q000235:genetics* / Q000628:therapy*; D005260:Female; D005836:Genitalia, Female / Q000382:microbiology; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D008954:Models, Biological; D014367:Tryptophan Synthase / Q000235:genetics*
chemical_list: D007371:Interferon-gamma; D014367:Tryptophan Synthase