Sensory irritation due to methyl-2-cyanoacrylate, ethyl-2-cyanoacrylate, isopropyl-2-cyanoacrylate and 2-methoxyethyl-2-cyanoacrylate in mice.
The expiratory bradypnoea indicative of upper airway irritation in mice was evaluated during a period of 60 min of nasal exposure to methyl-2-cyanoacrylate, ethyl-2-cyanoacrylate, isopropyl-2-cyanoacrylate and 2-methoxyethyl-2-cyanoacrylate vapors using nose only exposure. Irritation of the upper respiratory tract caused a concentration-dependent decrease in the respiratory rate. The maximum effect occurred within the first 10 min of exposure and was followed by a drop-off in the response during the remainder of the exposure period. The airborne concentration resulting in a 50% decrease in the respiratory rate of mice (RD(50)) was calculated for each chemical. The results show that the four chemicals had similar irritant potencies. The RD(50) values of methyl-2-cyanoacrylate, ethyl-2-cyanoacrylate, isopropyl-2-cyanoacrylate and 2-methoxyethyl-2-cyanoacrylate were 1.4, 0.7, 0.6 and 1.0 p.p.m. Tentative estimates of threshold limit values showed that 0.1 RD(50) was closer to the values recommended by the American Conference of Governmental Industrial Hygienists for methyl- and ethyl-2-cyanoacrylate than 0.03 RD(50). On the basis of a threshold limit value for short-term exposure limit (TLV STEL) equal to 0.1 RD(50), the TLV STELs for the four cyanoacrylates should not exceed 0.1 or 0.2 p.p.m.
Gagnaire
François
F
Department of Pollutants and Health, National Institute for Research and Safety, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre, France. gagnaire@inrs.fr
Marignac
Brigitte
B
Morel
Georges
G
Nunge
Hervé
H
Grossmann
Stéphane
S
D000818:Animals; D001681:Biological Assay / Q000379:methods; D003487:Cyanoacrylates / Q000009:adverse effects*; D006967:Hypersensitivity / Q000209:etiology; D007509:Irritants / Q000009:adverse effects*; D008452:Maximum Allowable Concentration; D051379:Mice; D023421:Models, Animal; D016273:Occupational Exposure / Q000009:adverse effects*; D012129:Respiratory Function Tests / Q000379:methods; D012140:Respiratory Tract Diseases / Q000150:complications*; D012677:Sensation
D003487:Cyanoacrylates; D007509:Irritants