title: Patterns of premorbid functioning in first-episode psychosis: initial presentation.
abstract: Premorbid functioning in first-episode psychosis has been reported to be associated with poorer outcome. We assessed premorbid functioning in a sample of 306 subjects newly admitted to an early-psychosis program. Using cluster analyses, we identified four patterns: stable-good, stable-moderate, deteriorating and poor-deteriorating. Results were that relative to the stable-good group, the deteriorating and the poor-deteriorating groups had more negative symptoms, poorer social functioning and some evidence of poorer cognitive functioning. The deteriorating group had increased positive symptoms compared to the stable-good group. These results suggest that prior to the onset of the acute psychosis those who have poor social and interpersonal functioning premorbidly present initially with increased social impairment and negative symptoms compared to those who have better premorbid functioning.
authors.affiliation: Department of Psychiatry, University of Calgary, Calgary, AB, Canada. jean_addington@camh.net
authors.forename: Jean
authors.initials: J
authors.lastname: Addington
authors.forename: Sarah
authors.initials: S
authors.lastname: van Mastrigt
authors.forename: Donald
authors.initials: D
authors.lastname: Addington
mesh_terms: D000293:Adolescent; D000328:Adult; D003702:Delusions / Q000175:diagnosis / Q000523:psychology; D003863:Depression / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006212:Hallucinations / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D009483:Neuropsychological Tests; D010555:Personality Inventory; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000523:psychology; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis* / Q000523:psychology; D012917:Social Adjustment; D012951:Socialization