Anti-inflammatory and analgesic activity of Bouchea fluminensis.
Dried leaves extract from Bouchea fluminensis was assessed in anti-inflammatory (mouse paw edema) and analgesic models (acetic acid-induced writhings and hot plate). Oral pretreatment of animals with a crude mixture (IG) and a purified mixture of ursolic, oleanolic and micromeric acids (IG-59) at doses ranging from 1 to 30 mg/kg, significantly inhibited carrageenin-induced edema formation. At the same doses, IG and IG-59 also exhibited peripheral and central analgesic activity. It seems that B. fluminensis triterpenes develop their analgesic effect through central opioid receptors, due to the observation that naloxone reverted analgesic activity on the hot plate model.
Costa
V B
VB
Departamento de Farmacologia, ICB, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Coube
C S
CS
Marinho
B G
BG
Matheus
M E
ME
Leitão
S G
SG
Fernandes
P D
PD
D019342:Acetic Acid; D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D006632:Histamine; D006358:Hot Temperature; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D012701:Serotonin; D029648:Verbenaceae
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012701:Serotonin; D006632:Histamine; D002351:Carrageenan; D019342:Acetic Acid