Myofibroblasts proliferation of idiopathic and collagen vascular disorders associated nonspecific interstitial pneumonia.
Nonspecific interstitial pneumonia (NSIP) has been recognized as a separate histological classification of interstitial lung disease. Similar features are found not only in idiopathic NSIP, but also in NSIP associated with collagen vascular disorder (CVD-NSIP). We examined the clinical symptoms, laboratory findings, and prognosis of 13 cases of idiopathic NSIP and 11 cases of CVD-NSIP. Immunohistochemical staining was performed using the streptavidin/biotin/peroxidase method with anti-alpha-smooth muscle actin antibody. No differences in the distribution of clinical features, laboratory findings, and prognosis were observed between idiopathic NSIP and CVD-NSIP. In immunohistochemical staining of the fibrosing areas, myofibroblasts were observed in 7 of 13 idiopathic NSIP cases, but in 10 of 11 CVD-NSIP cases. With regards to intra-alveolar organization, myofibroblasts were observed in all 10 CVD-NSIP cases, but they were observed in only 2 of 9 idiopathic NSIP cases. We found a significantly higher myofibroblast proliferation in the intra-alveolar organization of CVD-NSIP compared to idiopathic NSIP. Clinically, idiopathic NSIP and CVD-NSIP are similar, but are pathologically different.
Niimi
Takashi
T
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Science, Nagoya 467 8601, Japan. tniimi@med.nagoya-cu.ac.jp
Yoshinouchi
Takeo
T
Ohtsuki
Yuji
Y
Fujita
Jiro
J
Sato
Shigeki
S
Sugiura
Yoshiki
Y
Ohta
Kazutaka
K
Kajiura
Motoharu
M
Ueda
Ryuzo
R
D000368:Aged; D002455:Cell Division; D003095:Collagen Diseases / Q000473:pathology*; D005260:Female; D005347:Fibroblasts / Q000166:cytology*; D006801:Humans; D007150:Immunohistochemistry; D017563:Lung Diseases, Interstitial / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014652:Vascular Diseases / Q000473:pathology*