[Progress in the study of physiological function of sphingosine 1-phosphate].
Sphingosine 1-phosphate, a bioactive sphingolipid produced from the metabolism of sphingomyelin, play important roles in diverse biological process, including cell proliferation, survival, cytoskeleton changes, migration, angiogenesis, wound healing and embryonic development. Here we review the role of sphingosine 1-phosphate in cell biological function regulation and signal transduction.
Duan
Hai-Feng
HF
Beijing Institute of Radiation Medicine, Beijing 100850.
Wang
Li-Sheng
LS
Wu
Chutse
C
D000818:Animals; D002478:Cells, Cultured; D006413:Hematopoietic System / Q000502:physiology; D006801:Humans; D008246:Lysophospholipids; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology; D043562:Receptors, G-Protein-Coupled; D049312:Receptors, Lysophospholipid; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000502:physiology*
D008246:Lysophospholipids; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D049312:Receptors, Lysophospholipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine