title: [Effects of microcirculatory disorders of inner ear on blood-labyrinth barrier permeability in guinea pigs].
abstract: OBJECTIVE
  To study the changes of blood-labyrinth barrier permeability during cochlea microcirculatory disorders in guinea pigs.
  
  
  METHODS
  Using modified method of Evan's blue fluorescence, the changes of permeability of blood-labyrinth barrier were observed in the animal model of cochlea microcirculatory disorders which was induced by photochemical reaction.
  
  
  RESULTS
  Amount of Evan's blue passing through the blood-labyrinth barrier was (1.709 +/- 0.769) microgram per guinea pig after 2 hours and (2.849 +/- 0.653) microgram per guinea pig after 4 hours when the cochlea was in microcirculatory disorder.
  
  
  CONCLUSIONS
  The results indicated that the permeability of blood-labyrinth barrier increased when cochlea microcirculatory disorders occurred and the increase of blood-labyrinth barrier permeability may be one of the important mechanisms which causes the cochlear ischemic lesions.
authors.affiliation: Department of Otorhinolaryngology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. yingsc@public.cta.cq.cn
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D007758:Ear, Inner / Q000098:blood supply*; D005260:Female; D006168:Guinea Pigs; D007511:Ischemia / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation