title: Prevention of persistent infection in calves by vaccination of dams with noncytopathic type-1 modified-live bovine viral diarrhea virus prior to breeding.
abstract: OBJECTIVE
  To determine the ability of a modified-live virus (MLV) bovine viral diarrhea virus (BVDV) type 1 (BVDV1) vaccine administered to heifers prior to breeding to stimulate protective immunity that would block transmission of virulent heterologous BVDV during gestation, thus preventing persistent infection of a fetus.
  
  
  METHODS
  40 crossbred Angus heifers that were 15 to 18 months old and seronegative for BVDV and 36 calves born to those heifers.
  
  
  METHODS
  Heifers were randomly assigned to control (n = 13) or vaccinated (27) groups. The control group was administered a multivalent vaccine where-in the BVDV component had been omitted. The vaccinated heifers were administered a single dose of vaccine (IM or SC) containing MLV BVDV1 (WRL strain). All vaccinated and control heifers were maintained in pastures and exposed to BVDV-negative bulls 21 days later. Thirty-five heifers were confirmed pregnant and were challenge exposed at 55 to 100 days of gestation by IV administration of virulent BVDV1 (7443 strain).
  
  
  RESULTS
  All control heifers were viremic following challenge exposure, and calves born to control heifers were persistently infected with BVDV. Viremia was not detected in the vaccinated heifers, and 92% of calves born to vaccinated heifers were not persistently infected with BVDV.
  
  
  CONCLUSIONS
  These results document that vaccination with BVDV1 strain WRL protects fetuses from infection with heterologous virulent BVDV1.
authors.affiliation: Research and Development Division, Mallinckrodt Veterinary Inc, 909 Orchard St, Mundelein, IL 60060, USA.
authors.forename: Hansi J
authors.initials: HJ
authors.lastname: Dean
authors.forename: Breck D
authors.initials: BD
authors.lastname: Hunsaker
authors.forename: O Dale
authors.initials: OD
authors.lastname: Bailey
authors.forename: Terri
authors.initials: T
authors.lastname: Wasmoen
mesh_terms: D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*; D002417:Cattle; D030241:Diarrhea Virus 1, Bovine Viral / Q000276:immunology* / Q000302:isolation & purification; D005260:Female; D005333:Fetus / Q000821:virology; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control* / Q000662:veterinary*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control / Q000662:veterinary / Q000821:virology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014766:Viremia
chemical_list: D014765:Viral Vaccines