title: Effect of suplatast tosilate, an antiallergic selective Th2 cytokine inhibitor, on acute eosinophilic myocarditis: a case report.
abstract: We encountered a 44-year-old woman with acute eosinophilic myocarditis that showed positive immunostaining for interleukin-4 in the area of marked infiltration of eosinophils into the myocardium. When prednisolone alone proved ineffective, supplementary treatment with suplatast tosilate, an antiallergic selective Th2 cytokine inhibitor, improved the patient's inflammation, reduced the level of cardiac enzymes, and allowed for a reduction in corticosteroid dosage without any adverse effects.
authors.affiliation: Pharmaceutical Clinical Research Center, Yamaguchi University Hospital, 1-1-1 Minami Kogushi, Ube, Japan. umemoto@yamaguchi-u.ac.jp
authors.forename: Seiji
authors.initials: S
authors.lastname: Umemoto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Itagaki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kimura
authors.forename: Shinichi
authors.initials: S
authors.lastname: Itoh
authors.forename: Masakazu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Haraguchi
authors.forename: Masunori
authors.initials: M
authors.lastname: Matsuzaki
mesh_terms: D000208:Acute Disease; D000328:Adult; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001190:Arylsulfonates / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004804:Eosinophils / Q000187:drug effects*; D005260:Female; D006801:Humans; D015847:Interleukin-4 / Q000037:antagonists & inhibitors*; D009205:Myocarditis / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage; D013452:Sulfonium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology*; D013997:Time Factors
chemical_list: D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D001190:Arylsulfonates; D013452:Sulfonium Compounds; D015847:Interleukin-4; D011239:Prednisolone; C073028:suplatast tosilate