Profiling breast cancer by array CGH.
Breast tumors display a wide variety of genomic alterations. This review focuses on DNA copy number variations in these tumors as measured by the recently developed microarray-based form of comparative genomic hybridization. The capabilities of this new technology are reviewed. Initial applications of array CGH to the analysis of breast cancer, and the mechanisms by which the particular types of copy number changes might arise are discussed.
Albertson
Donna G
DG
Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143-0808, USA. albertson@cc.ucsf.edu
D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005784:Gene Amplification; D018628:Gene Dosage; D020869:Gene Expression Profiling; D006801:Humans; D009693:Nucleic Acid Hybridization / Q000379:methods*