Periodontal pathogens in subgingival plaque of HIV-positive subjects with chronic periodontitis.
Many putative periodontal pathogens associated with periodontal disease in human immunodeficiency virus (HIV)-infected patients also occur in non-HIV-infected individuals. This study examined the prevalence of eight periodontal pathogens in HIV-positive and HIV-negative patients with chronic periodontitis using the 16s RNA polymerase chain reaction technique. The results showed a significant prevalence of Porphyromonas gingivalis and Treponema denticola among HIV-negative patients compared to HIV-positive patients. Sixty percent of the patients in both groups were colonized by five to six species. Odds ratio analysis revealed a statistically significant positive association between three of the 28 possible combinations in the HIV-positive group. They included Prevotella nigrescens/Campylobacter rectus, P. nigrescens/P. gingivalis and P. nigrescens/T. denticola. Although the prevalence of periodontal pathogens is similar in both the groups, the combination of certain periodontal pathogens may be responsible for chronic periodontitis seen in HIV-infected adults.
Patel
M
M
Division of Oral Microbiology, Department of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg, South Africa. patelms@dentistry.wits.ac.za
Coogan
M
M
Galpin
J S
JS
D000328:Adult; D001421:Bacteria, Anaerobic / Q000302:isolation & purification; D002908:Chronic Disease; D003773:Dental Plaque / Q000150:complications / Q000382:microbiology*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D010518:Periodontitis / Q000150:complications* / Q000382:microbiology