title: Chiral sulfoxides as neutral coordinate-organocatalysts in asymmetric allylation of N-acylhydrazones using allyltrichlorosilanes.
abstract: Sulfoxides were first introduced to the allylation of N-acylhydrazones with allyltrichlorosilanes as effective neutral coordinate-organocatalysts (NCOs). Both high diastereo- and enantioselectivity were attained when optically active chiral sulfoxides were used. Asymmetric crotylations using (Z)- and (E)-crotyltrichlorosilanes showed a high level of stereospecificity (Z --> anti and E --> syn) with high enantioselectivity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Shū
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Chikako
authors.initials: C
authors.lastname: Ogawa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Konishi
authors.forename: Masaharu
authors.initials: M
authors.lastname: Sugiura