[A reappraisal of hyperbaric oxygenation effect and study on serum malondialdehyde and superoxide dismutase in patients with sudden deafness].
OBJECTIVE
To reappraise the effect of HBO and to observe the changes of malondialdehyde (MDA) and superoxide dismutase (SOD) in serum of the patients with sudden deafness.


METHODS
60 patients were randomly divided into two groups. One was treated with HBO combined with medical treatment (treatment group). The other was only treated with HBO (control group). There were 30 healthy volunteers as health group.


RESULTS
After treatment, there was a significant difference (chi 2 = 6.48, P < 0.05) in patient's groups in hearing examination. After treatment, SOD volume in treatment group had significant difference with health group and control group (t = 23.27, P < 0.01; t = 27.17, P < 0.01) respectively. There was a significant difference of SOD volume in treatment group itself before and after treatment course (t = 29.27, P < 0.01). There was no significant difference of SOD volume in control group itself before and after treatment(t = 1.33, P > 0.05). MDA: There was a significant difference between treatment group and control one after the treatment. There was a significant difference (t = 7.28, P < 0.01) in treatment group before and after treatment course. There was not a significant difference (t = 1.24, P > 0.05) between treatment and health group after the treatment course. There was a significant difference (t = 7.09, P < 0.01) between control group and health one after the treatment course.


CONCLUSIONS
There was no satisfied curative effect on sudden deafness with HBO only.
Wang
W
W
Department of Otorhinolaryngology, Overseas Chinese Federation Hospital of Shandong, Zibo 255031, China. yongyi@zb-public.sd.cninfo.net
Xu
R
R
Lu
R
R
Yan
Y
Y
D000328:Adult; D000368:Aged; D005260:Female; D006309:Hearing; D003639:Hearing Loss, Sudden / Q000097:blood / Q000201:enzymology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood*
D008315:Malondialdehyde; D013482:Superoxide Dismutase