title: Treatment and outcomes of oesophageal perforation in a tertiary referral centre.
abstract: OBJECTIVE
  The diagnosis and management of oesophageal perforation continues to challenge clinicians. We present our experience of perforated oesophagus in a Tertiary Referral Centre for Thoracic and Oesophageal Surgery.
  
  
  METHODS
  Between 1985 and 2000, 75 patients (40 male) with oesophageal perforation were treated in out unit; age range 24-89, median 63. Retrospective review of these cases has been performed.
  
  
  RESULTS
  There were 12 deaths (16%). With increases in time from perforation to diagnosis, there was a stepwise increase in the mortality rate. Immediate diagnosis 5%; early diagnosis (1-24h) 14%; late diagnosis (>24h) 44% (P>or=0.002). Site of perforation, aetiology, and treatment strategy had no influence on mortality. The only independent predictor of mortality identified was time to diagnosis from perforation (beta 0.429, P=0.001). Time to definitive management in those undergoing an operative procedure had no influence on outcome with multivariate analysis.
  
  
  CONCLUSIONS
  Prompt recognition of the diagnosis of oesophageal perforation and rapid institution of supportive measures, followed by an appropriate, patient specific treatment option optimises the chance of a successful outcome. The wide range of presentation of oesophageal perforation necessitates individualisation of treatment.
authors.affiliation: Department of Thoracic Surgery, Royal Victoria Hospital, Belfast, Northern Ireland, UK.
authors.forename: A D
authors.initials: AD
authors.lastname: Muir
authors.forename: J
authors.initials: J
authors.lastname: White
authors.forename: J A
authors.initials: JA
authors.lastname: McGuigan
authors.forename: K G
authors.initials: KG
authors.lastname: McManus
authors.forename: A N
authors.initials: AN
authors.lastname: Graham
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004322:Drainage; D004939:Esophageal Perforation / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D013997:Time Factors; D016896:Treatment Outcome