title: The effects of dentate granule cell destruction on behavioral activity and Fos protein expression induced by systemic MDMA in rats.
abstract: In this study, we examined the effect of the s.c. administration of (+/-) 3,4-methylenedioxymethamphetamine (MDMA) or saline on locomotor activity and Fos expression following the bilateral destruction of hippocampal dentate granule cells by colchicine in rats. The lesioned animals, when administered s.c. saline, showed a significantly greater increase in locomotor activity compared to the intact animals, and revealed a marginally significant level of increased locomotor activity compared to the sham-lesioned animals. In addition, when the lesioned animals were given s.c. saline or MDMA, there was a significant increase in Fos expression in the nucleus accumbens core, but not in the medial prefrontal cortex, dorsolateral prefrontal cortex, anterior cingulate cortex, piriform cortex, dorsal striatum, or nucleus accumbens shell, compared to the intact and sham-lesioned animals. Overall, these results suggest that the nucleus accumbens core may be involved in the enhancement of locomotor activity induced by the injection of saline alone (stress loading) or MDMA following bilateral destruction of hippocampal dentate granule cells by colchicine.
authors.affiliation: Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.
authors.forename: Mujun
authors.initials: M
authors.lastname: Won
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Minabe
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Tani
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kawai
authors.forename: Yoshimoto
authors.initials: Y
authors.lastname: Sekine
authors.forename: Charles R
authors.initials: CR
authors.lastname: Ashby
authors.forename: Nori
authors.initials: N
authors.lastname: Takei
authors.forename: Norio
authors.initials: N
authors.lastname: Mori
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003078:Colchicine / Q000008:administration & dosage / Q000633:toxicity; D018891:Dentate Gyrus / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006213:Hallucinogens / Q000494:pharmacology*; D007150:Immunohistochemistry; D007276:Injections, Intraventricular; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D006213:Hallucinogens; D016760:Proto-Oncogene Proteins c-fos; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D003078:Colchicine