A randomized controlled study of three targets of propofol plasma concentration in patients undergoing uterine dilation and curettage.
OBJECTIVE
To compare the efficacy and the complications of three target levels of propofol plasma concentration in patients undergoing uterine dilation and curettage.


METHODS
Sixty-nine patients were randomly allocated to receive propofol target controlled infusion at different target concentrations of 4 (group I), 5 (group II) and 6 (group III) mcg/mL combined with 1 microg/kg of fentanyl and 66% of nitrous oxide. Patients' movement during the procedure, hemodynamic variables, oxygen saturation, end tidal carbon dioxide, time to sleep and awake, and bispectral index score were recorded.


RESULTS
Seven patients in group I, one in group II, and none in group III (P < 0.05) moved grossly during the procedure. More patients in group III developed hypotension (5 vs 0 and 2 in group I and II, P < 0.05), but no difference was found regarding respiratory complication. No difference was found in time to sleep, but time to wake was longer in group III.


CONCLUSIONS
Propofol infusion at the target concentration of 5 microg/mL was recommended for uterine dilation and curettage when it was administered with fentanyl 1 microg/kg and nitrous oxide 66% under close monitoring and appropriate respiratory management.
Uerpairojkit
Ketchada
K
Department of Anesthesia, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Pratumwan, Bangkok, Thailand. ketchada@hotmail.com
Urusopone
Pakorn
P
Somboonviboon
Wanna
W
D000293:Adolescent; D000328:Adult; D000762:Anesthesia Recovery Period; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D004107:Dilatation and Curettage; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D010100:Oxygen / Q000097:blood; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D015656:Respiratory Mechanics / Q000187:drug effects; D016896:Treatment Outcome; D014599:Uterus / Q000601:surgery*
D018686:Anesthetics, Intravenous; D010100:Oxygen; D015742:Propofol