Effect of ergotamine on plasma metabolite and insulin-like growth factor-1 concentrations in cows.
Bovine plasma was assayed to determine if ergotamine affected plasma metabolite and insulin-like growth factor-1 (IGF-1) concentrations. In Experiment 1, four cows received a single bolus intravenous injection of ergotamine tartrate (19 microg/kg body wt.) or saline vehicle in a crossover design 2 days after prostaglandin-induced luteolysis. Treatmentxtime affected plasma glucose, triglyceride, total cholesterol and IGF-1 concentrations. Glucose and cholesterol were increased after ergotamine. Triglycerides were elevated within 1 h after ergotamine, but were decreased 3 h after ergotamine treatment. Plasma IGF-1 decreased in response to ergotamine. Blood constituents were unchanged after treatment with saline. In Experiment 2, six cows received a single bolus intravenous injection of ergotamine (20 microg/kg body wt.) or saline vehicle in a crossover design 10 days after receiving norgestomet (6 mg) via subcutaneous ear implant. Treatmentxtime affected glucose, triglycerides, total cholesterol and IGF-1 concentrations. Glucose and cholesterol were increased after ergotamine. Triglycerides were elevated 1 h after ergotamine and decreased 3-7 h after ergotamine. Plasma IGF-1 decreased after ergotamine treatment. Blood constituents were unresponsive to the saline vehicle. Results indicated ergotamine altered plasma metabolite and IGF-1 concentrations in cows.
Browning
Richard
R
Cooperative Agricultural Research Program, Tennessee State University, 3500 John A. Merritt Blvd., Nashville, TN 37209-1561, USA. rbrowning@tnstate.edu
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002417:Cattle; D002784:Cholesterol / Q000097:blood; D004334:Drug Administration Schedule / Q000662:veterinary; D004878:Ergotamine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005260:Female; D007275:Injections, Intravenous / Q000662:veterinary; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
D000316:Adrenergic alpha-Agonists; D001786:Blood Glucose; D014280:Triglycerides; D007334:Insulin-Like Growth Factor I; D002784:Cholesterol; D004878:Ergotamine