Phospholamban inhibits Ca2+ pump oligomerization and intersubunit free energy exchange leading to activation of cardiac muscle SERCA2a.
Mahaney
James E
JE
Department of Biochemistry, West Virginia University, Morgantown 26506, USA. jmahaney@hsc.wvu.edu
Albers
R Wayne
RW
Kutchai
Howard
H
Froehlich
Jeffrey P
JP
D000818:Animals; D002135:Calcium-Binding Proteins / Q000494:pharmacology*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors; D007700:Kinetics; D046911:Macromolecular Substances; D008958:Models, Molecular; D018482:Muscle, Skeletal; D011487:Protein Conformation; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D013816:Thermodynamics; D000099211:Phospholamban
D002135:Calcium-Binding Proteins; D000252:Calcium-Transporting ATPases; D004791:Enzyme Inhibitors; D046911:Macromolecular Substances; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D000099211:Phospholamban