title: Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections.
abstract: Pantothenate kinase (CoaA) catalyzes the first step of the coenzyme A biosynthetic pathway. Here we report the identification of the Staphylococcus aureus coaA gene and characterization of the enzyme. We have also identified a series of low-molecular-weight compounds which are effective inhibitors of S. aureus CoaA.
authors.affiliation: Microbial, Musculoskeletal and Proliferative Diseases and Bioinformatics, GlaxoSmithKline Pharmaceuticals, Collegeville Pennsylvania 19426, USA.
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Choudhry
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Mandichak
authors.forename: John P
authors.initials: JP
authors.lastname: Broskey
authors.forename: Richard W
authors.initials: RW
authors.lastname: Egolf
authors.forename: Cynthia
authors.initials: C
authors.lastname: Kinsland
authors.forename: Tadhg P
authors.initials: TP
authors.lastname: Begley
authors.forename: Mark A
authors.initials: MA
authors.lastname: Seefeld
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Ku
authors.forename: James R
authors.initials: JR
authors.lastname: Brown
authors.forename: Magdalena
authors.initials: M
authors.lastname: Zalacain
authors.forename: Kapila
authors.initials: K
authors.lastname: Ratnam
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D003065:Coenzyme A / Q000096:biosynthesis; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010205:Pantothenic Acid / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors* / Q000235:genetics; D010802:Phylogeny; D016415:Sequence Alignment; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000201:enzymology* / Q000235:genetics; D014407:Tumor Cells, Cultured
chemical_list: D004269:DNA, Bacterial; D004791:Enzyme Inhibitors; D010205:Pantothenic Acid; D000255:Adenosine Triphosphate; D017853:Phosphotransferases (Alcohol Group Acceptor); C023088:pantothenate kinase; D003065:Coenzyme A