title: Antimalarial dihydroisocoumarins produced by Geotrichum sp., an endophytic fungus of Crassocephalum crepidioides.
abstract: Three novel dihydroisocoumarin derivatives (1-3) with antimalarial, antituberculous, and antifungal activities have been isolated by bioassay-guided fractionation from an endophytic fungus, Geotrichum sp., collected from Crassocephalum crepidioides. Structures were established as 7-butyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (1), 7-but-15-enyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one (2), and 7-butyl-6,8-dihydroxy-3(R)-pentylisochroman-1-one (3) using spectroscopic data.
authors.affiliation: Department of Chemistry and Center for Protein Structure and Function, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. scpks@mahidol.ac.th
authors.forename: Palangpon
authors.initials: P
authors.lastname: Kongsaeree
authors.forename: Samran
authors.initials: S
authors.lastname: Prabpai
authors.forename: Nongluksna
authors.initials: N
authors.lastname: Sriubolmas
authors.forename: Chanika
authors.initials: C
authors.lastname: Vongvein
authors.forename: Suthep
authors.initials: S
authors.lastname: Wiyakrutta
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005848:Geotrichum / Q000737:chemistry*; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum / Q000187:drug effects; D013237:Stereoisomerism; D013785:Thailand
chemical_list: C478279:7-but-15-enyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one; C478278:7-butyl-6,8-dihydroxy-3(R)-pent-11-enylisochroman-1-one; C478280:7-butyl-6,8-dihydroxy-3(R)-pentylisochroman-1-one; D000935:Antifungal Agents; D000962:Antimalarials; D000995:Antitubercular Agents; D003374:Coumarins