[Studies on the anti-inflammation effect of the TCM prescription of a combination of monkshood root with peony root].
OBJECTIVE
To make a comparison between the single and combined use of Monkshood Root and Peony Root to observe the anti-inflammation effect in the experimental animals.


METHODS
The experimental inflammatory models were adopted, i.e. adjuvant-induced polyarthritis carrageenan-induced or formaldehyde-induced rat paw edema, and cotton pellet-induced granuloma formation in rats xylene-induced mouse ear edema, exudation of abdominal blood capillaries of mice, etc.


RESULTS
The anti-inflammafion effect of Monkshood Root was weaker than that of Peony Root or Peony Root combined with Monkshood Root. It was found that anti-inflammation effect with the drug-cooperation was enhanced more significantly in the formaldehyde-induced or adjuvant-induceed arthritis models than in the carrageenan-induced rat paw edema and other inflammatory models either in the large dosage of 1:1 proportion or in the small dosage of 1:2 proportion.


CONCLUSIONS
The drug-cooperation has a good selective and synergic effect on anti-inflammation.
Zhang
Hui-yun
HY
Shandong University of TCM, Jinan 250014, Shandong, China.
Qin
Lin
L
Xue
Ling
L
Zhang
Shao-hua
SH
D031841:Aconitum / Q000737:chemistry*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy*; D005260:Female; D015745:Granuloma, Foreign-Body / Q000188:drug therapy; D008297:Male; D051379:Mice; D029596:Paeonia / Q000737:chemistry*; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal