title: [Prognosis of chronic renal failure in patients with membranous nephropathy].
abstract: Two hundred eighty patients underwent renal biopsy during the period of 1995-1999 in five nephrological centers of Lithuania. All renal biopsies materials were examined in the State Center of Pathology. In 20 patients (7.1%) membranous nephropathy was found. The main clinical presentation at the moment of renal biopsy were nephrotic syndrome (55%) and arterial hypertension (55%). Glomerulosclerosis was found in 30% of patients, interstitial fibrosis--in 40% of patients. The results of analysis showed multiple risk factors for renal failure progression: initial renal failure (p=0.000), systolic and diastolic hypertension (p=0.009 and p=0.009), proteinuria (=1 g/l, =3 g/l) (p=0.026). Membranous nephropathy was found to have a relatively good long-term prognosis - the renal survival rate in 5 years was 84.2%. Kaplan-Meier survival analysis showed that initial renal failure was risk factor (logrank p=0.018, Breslov p=0.032) associated with development of end-stage renal disease in 5 years.
authors.affiliation: Clinic of Nephrology, Kaunas University of Medicine Hospital, Kaunas, Lithuania.
authors.forename: Loreta
authors.initials: L
authors.lastname: Razukeviciene
authors.forename: Vytautas
authors.initials: V
authors.lastname: Kuzminskis
authors.forename: Inga Arūne
authors.initials: IA
authors.lastname: Bumblyte
authors.forename: Arvydas
authors.initials: A
authors.lastname: Laurinavicius
mesh_terms: D058186:Acute Kidney Injury / Q000473:pathology; D000328:Adult; D000368:Aged; D001706:Biopsy; D016009:Chi-Square Distribution; D003627:Data Interpretation, Statistical; D003971:Diastole; D018450:Disease Progression; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000473:pathology; D053208:Kaplan-Meier Estimate; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013599:Systole