[Rheologic properties of Vivastar P 5000 hydrogel].
Within the framework of pre-formulation studies, the paper evaluates the rheological properties of hydrogels whose gel-forming substance is a polymer supplied by the firm J. Rettenmaier & SöhneGMBH + CO. It is VIVASTAR P 5000, a modified derivate of carboxymethyl starch. The evaluation of rheological properties included hydrogels with 1.5, 2.0 and 2.5 w % of VIVASTAR P 5000. The highest viscosity was shown by the hydrogel with 2.0% concentration of the polymer. The system without and with the model drug with a local anaesthetic effect was thixotropic. From the viewpoint of topical administration, VIVASTAR P 5000 in 2.0% is optimal for hydrogel formulation.
Vitková
Z
Z
Katedra galenickej farmácie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Skarbalová
M
M
Cirbusová
E
E
Rak
J
J
D020100:Hydrogels; D010592:Pharmaceutic Aids / Q000737:chemistry*; D012212:Rheology; D013213:Starch / Q000031:analogs & derivatives* / Q000737:chemistry*; D013678:Technology, Pharmaceutical; D014783:Viscosity
D020100:Hydrogels; D010592:Pharmaceutic Aids; D013213:Starch; C034848:carboxymethyl starch