[Chemical constituents from the fruit of Rosa bella Rehd. et Wils].
OBJECTIVE
To investigate the chemical constituents from the fruit of Rosa bella and its bioactivity.


METHODS
The compounds were isolated from the methanol extract by column chromatography, then identified by 1H, 13C NMR and by comparison with authentic samples. The unorganized hoptoad heart was used for testing the contracting force of cardiac muscle and enzymology for measuring the bloody lipid of serum in rats.


RESULTS
Seven compounds were isolated and identified as pomolic acid, tiliroside, euscaphic acid, daucosterol, quercetin, oleanolic acid and beta-sitosterol, respectively. In the concentration of 0.4-1.0 mg.ml-1, the methanol extract had obvious cardiotonic effect. While at 400 mg.kg-1, there are no obvious effect to the TC, HDL-ac and TG of serum in rats.


CONCLUSIONS
The isolated compounds may be the active components of this plant.
Chen
F Z
FZ
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, Sichuan, China.
Peng
S L
SL
Ding
L S
LS
He
Y H
YH
Wang
M K
MK
D000818:Animals; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002023:Bufo bufo; D002784:Cholesterol / Q000097:blood; D005419:Flavonoids; D005638:Fruit / Q000737:chemistry; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D027826:Rosa / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D001578:Benzopyrans; D005419:Flavonoids; D008075:Lipoproteins, HDL; D014280:Triglycerides; D014315:Triterpenes; C052083:tiliroside; C007695:euscaphic acid; C115535:pomolic acid; D009828:Oleanolic Acid; D002784:Cholesterol