The present view of the mechanism of protein folding.
We can track the positions and movements of all the atoms in small proteins as they fold and unfold by combining experimental studies with atomic-resolution molecular dynamics simulations. General principles as to how such complex architectures form so rapidly are now emerging from in-depth studies of a few proteins.
Daggett
Valerie
V
Department of Medicinal Chemistry, Box 357610, University of Washington, Seattle, Washington 98195-7610, USA. daggett@u.washington.edu
Fersht
Alan
A
D001426:Bacterial Proteins; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry; D010940:Plant Proteins; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry; D012260:Ribonucleases / Q000737:chemistry; D013696:Temperature; D013816:Thermodynamics
D001426:Bacterial Proteins; D010455:Peptides; D010940:Plant Proteins; D011506:Proteins; C093336:chymotrypsin inhibitor 2; D012260:Ribonucleases; C019760:Bacillus amyloliquefaciens ribonuclease