Large antigens such as GAD-65 become involved in pathogenic self-reactivity, but fortunately only rarely.
Sercarz
Eli E
EE
Torrey Pines Institute for Molecular Studies, La Jolla, CA, USA. esercarz@tpims.org
D000818:Animals; D017951:Antigen Presentation; D001324:Autoantigens; D015551:Autoimmunity; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology / Q000209:etiology / Q000276:immunology; D005968:Glutamate Decarboxylase / Q000276:immunology*; D007527:Isoenzymes / Q000276:immunology*; D051379:Mice; D016688:Mice, Inbred NOD; D013601:T-Lymphocytes / Q000276:immunology
D001324:Autoantigens; D007527:Isoenzymes; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2