title: Sipaucins A-C, sesquiterpenoids from Siparuna pauciflora.
abstract: The phytochemical investigation of the leaves of Siparuna pauciflora yielded three novel sesquiterpenoids: the germacrane sipaucin A, the elemane sipaucin B and sipaucin C, comprising a new type of carbon skeleton. In addition, four known aporphine alkaloids-nor-boldine, boldine, laurotetanine, and N-methyl-laurotetanine-were obtained. The evaluation of the antiplasmodial activity of the isolated compounds against two strains of Plasmodium falciparum (PoW, Dd2) showed a moderate activity of nor-boldine.
authors.affiliation: Institut für Pharmazie (Pharmazeutische Biologie), Freie Universität Berlin, Königin-Luise-Str. 2-4, D-14195 Berlin, Germany. kjsiems@zedat.fu-berlin.de
authors.forename: Kristina
authors.initials: K
authors.lastname: Jenett-Siems
authors.forename: Carola
authors.initials: C
authors.lastname: Kraft
authors.forename: Karsten
authors.initials: K
authors.lastname: Siems
authors.forename: Jasmin
authors.initials: J
authors.lastname: Jakupovic
authors.forename: Pablo N
authors.initials: PN
authors.lastname: Solis
authors.forename: Mahabir P
authors.initials: MP
authors.lastname: Gupta
authors.forename: Ulrich
authors.initials: U
authors.lastname: Bienzle
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D029585:Monimiaceae / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000981:Antiprotozoal Agents; D012717:Sesquiterpenes