[Morphologic and functional abnormalities of the cardiovascular system in patients with hepatic cirrhosis].
During liver cirrhosis many important changes occur in the cardiovascular system and these abnormalities appear more evident as portal hypertension and liver dysfunction progress. The cirrhotic heart develops a series of structural and functional abnormalities consisting in diastolic dysfunction and reduced myocardial reactivity during exercise, likely due to a diminished myocardial beta-adrenergic receptor function. Nevertheless, the peculiarity of the cardiovascular involvement during liver cirrhosis is represented by a progressive development of a hyperdynamic circulation that seems to be due to portal hypertension rather than to liver insufficiency. In fact, it has been hypothesized that this syndrome raise from the venous portal bed and is primarily determined by an increase in blood volume that leads to an enhanced cardiac output. Later, as liver cirrhosis progresses, new important pathogenetic elements occur and lead to a reduction in peripheral vascular resistances and to the full clinical expression of hyperdynamic circulation. The pathogenesis of hyperdynamic circulation is very interesting for scientific research because of the complex and still in part unknown origin. In addition, this syndrome has an important clinical meaning for its severely adverse prognostic value and it represents the pathogenetic background for a number of severe complications of advanced liver cirrhosis.
Piscione
Federico
F
Cattedra di Cardiologia Università degli Studi Federico II Via S. Pansini, 5 80131 Napoli. piscione@unina.it
Manganiello
Vincenzo
V
Viola
Orazio
O
Chiariello
Massimo
M
D001775:Blood Circulation / Q000502:physiology; D001810:Blood Volume; D003971:Diastole / Q000502:physiology; D018450:Disease Progression; D015444:Exercise / Q000502:physiology; D006331:Heart Diseases / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D006975:Hypertension, Portal / Q000188:drug therapy / Q000503:physiopathology; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D009200:Myocardial Contraction; D011379:Prognosis; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D012039:Regional Blood Flow; D013577:Syndrome; D014655:Vascular Resistance
D011943:Receptors, Adrenergic, beta