title: The fate of the prion protein in the prion/plasminogen complex.
abstract: The cellular prion protein (PrP(c)) forms complexes with plasminogen. Here, we show that the PrP(c) in this complex is cleaved to yield fragments of PrP(c). The cleavage is accelerated by plasmin but does not appear to be dependent on it.
authors.affiliation: Concordia University, 1455 de Maisonneuve Blvd., Montreal, Qc, Canada H3G 1M8. krnbltt@vax2.concordia.ca
authors.forename: Jack A
authors.initials: JA
authors.lastname: Kornblatt
authors.forename: Stephane
authors.initials: S
authors.lastname: Marchal
authors.forename: Human
authors.initials: H
authors.lastname: Rezaei
authors.forename: M Judith
authors.initials: MJ
authors.lastname: Kornblatt
authors.forename: Claude
authors.initials: C
authors.lastname: Balny
authors.forename: Reinhard
authors.initials: R
authors.lastname: Lange
authors.forename: Marie-Pascale
authors.initials: MP
authors.lastname: Debey
authors.forename: Gaston
authors.initials: G
authors.lastname: Hui Bon Hoa
authors.forename: Michael C
authors.initials: MC
authors.lastname: Marden
authors.forename: Jeanne
authors.initials: J
authors.lastname: Grosclaude
mesh_terms: D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D005341:Fibrinolysin / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances; D010446:Peptide Fragments / Q000378:metabolism; D010958:Plasminogen / Q000378:metabolism*; D018621:PrPC Proteins / Q000378:metabolism*; D012756:Sheep; D010959:Tissue Plasminogen Activator / Q000378:metabolism
chemical_list: D046911:Macromolecular Substances; D010446:Peptide Fragments; D018621:PrPC Proteins; D010958:Plasminogen; D010959:Tissue Plasminogen Activator; D005341:Fibrinolysin