title: [Proteins regulating neurotransmitter release of synaptic vesicles at nerve terminals].
abstract: Neurotransmitter release of synaptic vesicle at nerve terminals is a complicated and elaborately regulated process, involving a cascade of protein-protein interactions. The SNARE core complex consisting of synaptobrevin/VAMP (a synaptic-terminal protein), syntaxin and SNAP-25 (synaptic membrane-associated proteins), acts as the membrane fusion machinery and plays essential roles in synaptic vesicle exocytosis. This review will discuss proteins with potential roles in synaptic vesicle exocytosis by regulating assembly, disassembly and the function of SNARE complex, and sum up the molecular model of vesicle exocytosis.
authors.affiliation: Department of Neurobiology, Shanghai Second Medical University, Shanghai 200025.
authors.forename: Qian
authors.initials: Q
authors.lastname: Cai
authors.forename: Pei-Hua
authors.initials: PH
authors.lastname: Lu
authors.forename: Zu-Hang
authors.initials: ZH
authors.lastname: Sheng
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology*; D008958:Models, Molecular; D052066:N-Ethylmaleimide-Sensitive Proteins; D009411:Nerve Endings / Q000166:cytology / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D050600:SNARE Proteins; D013572:Synaptic Vesicles / Q000502:physiology*; D050825:Synaptosomal-Associated Protein 25; D033921:Vesicular Transport Proteins
chemical_list: D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; C118519:SNAPIN protein, human; D050600:SNARE Proteins; D050825:Synaptosomal-Associated Protein 25; D033921:Vesicular Transport Proteins; D052066:N-Ethylmaleimide-Sensitive Proteins