title: An endogenous Su(Hw) insulator separates the yellow gene from the Achaete-scute gene complex in Drosophila.
abstract: The best characterized chromatin insulator in Drosophila is the Suppressor of Hairy wing binding region contained within the gypsy retrotransposon. Although cellular functions have been suggested, no role has been found yet for the multitude of endogenous Suppressor of Hairy wing binding sites. Here we show that two Suppressor of Hairy wing binding sites in the intergenic region between the yellow gene and the Achaete-scute gene complex form a functional insulator. Genetic analysis shows that at least two proteins, Suppressor of Hairy wing and Modifier of MDG4, required for the activity of this insulator, are involved in the transcriptional regulation of Achaete-scute.
authors.affiliation: Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, Moscow 117334, Russia.
authors.forename: Anton
authors.initials: A
authors.lastname: Golovnin
authors.forename: Inna
authors.initials: I
authors.lastname: Biryukova
authors.forename: Inna
authors.initials: I
authors.lastname: Birukova
authors.forename: Olga
authors.initials: O
authors.lastname: Romanova
authors.forename: Margarita
authors.initials: M
authors.lastname: Silicheva
authors.forename: Akeksander
authors.initials: A
authors.lastname: Parshikov
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Savitskaya
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Pirrotta
authors.forename: Pavel
authors.initials: P
authors.lastname: Georgiev
mesh_terms: D000483:Alleles; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D004251:DNA Transposable Elements; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000502:physiology*; D004330:Drosophila; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster; D004742:Enhancer Elements, Genetic; D005821:Genetic Techniques; D005838:Genotype; D008957:Models, Genetic; D016296:Mutagenesis; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics* / Q000502:physiology*; D012097:Repressor Proteins; D014157:Transcription Factors / Q000235:genetics*; D019076:Transgenes
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D004251:DNA Transposable Elements; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C089199:ac protein, Drosophila; C089197:sc protein, Drosophila; C083738:su(Hw) protein, Drosophila; C050680:y protein, Drosophila