Diversity within the DRB1*08 allele family in four populations from a United States hematopoietic stem cell donor database and characterization of five novel DRB1*08 alleles.
The frequencies of DRB1*08 alleles within four major United States populations found within a hematopoietic stem cell volunteer donor database were determined by DNA sequencing of over 60 DRB1*08 positive individuals from each group. Seven of 30 known DRB1*08 alleles were identified within this study population (080101, 080201, 080302, 080401, 0806, 0807, and 0811). Each ethnic group was characterized by a different highly prevalent allele: DRB1*080101 in Caucasians; DRB1*080401 in African-Americans; DRB1*080302 in Asians; and DRB1*080201 in Hispanics. The alleles DRB1*080101, DRB1*080201, and DRB1*080401 were present in all four populations. This report also describes five novel DRB1*08 alleles uncovered during routine human leukocyte antigen typing.
Rizzuto
Gabrielle
G
Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
Li
Li
L
Steiner
Noriko
N
Slack
Rebecca
R
Tang
Ting
T
Heine
Uwe
U
Lin
Yu Su
YS
Ng
Jennifer
J
Hartzman
RobertJ
R
Hurley
Carolyn Katovich
CK
D000483:Alleles; D005787:Gene Frequency; D014644:Genetic Variation; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006412:Hematopoietic Stem Cells; D006801:Humans; D017422:Sequence Analysis, DNA; D014019:Tissue Donors
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains