Two syntheses of FF-MAS.
[reaction: see text] Follicular fluid-meiosis activating sterol (FF-MAS) has been shown to be an efficient inducer of meiotic maturation. It can potentially be used for improvements of in vitro fertilization techniques. Two short synthesis of FF-MAS are presented in this article. Both syntheses are based on microbiological degradations of sterol side chains. FF-MAS can be synthesized in nine steps from commercially available starting materials by both routes.
Blume
Thorsten
T
Schering AG, Corporate Research, Research Center Europe, Medicinal Chemistry, D-13342 Berlin, Germany. thorsten.blume@schering.de
Guttzeit
Marc
M
Kuhnke
Joachim
J
Zorn
Ludwig
L
D002782:Cholestenes / Q000138:chemical synthesis*; D004875:Ergosterol / Q000737:chemistry; D005260:Female; D015571:Follicular Fluid / Q000737:chemistry*; D006801:Humans; D007202:Indicators and Reagents; D008540:Meiosis; D010084:Oxidation-Reduction; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D013261:Sterols / Q000737:chemistry*
D002782:Cholestenes; D007202:Indicators and Reagents; D013261:Sterols; C100324:4,4-dimethylcholesta-8,14,24-trienol; D004875:Ergosterol