[Intra-arterial thrombolysis for the treatment of restricted cochlear microcirculation disorder in guinea pigs].
OBJECTIVE
To ascertain a new treatment method for restricted cochlear microcirculation disorder.


METHODS
Photochemical reaction was utilized to induce localized microcirculation damage to the second cochlear turn of every guinea pig. The animals were divided into 5 groups. Group 1 was blank control. Group 2 and Group 3 were injected urokinase (UK) through left subclavian artery or left external jugular vein 30 minutes after photochemical reaction. Group 4 and Group 5 were two control groups. Instead of urokinase, saline injection was applied accordingly.


RESULTS
Both intra-arterial thrombolysis and intravenous thrombolysis were effective to improve the hearing levels and the blood supply to the inner ear. 50 minutes after urokinase injection, animals with intra-arterial thrombolysis showed a lower action potential threshold than that with intravenous thrombolysis (P = 0.025). And this phenomenon lasted 30 minutes. Cochlear blood flow of the animals with intra-arterial thrombolysis began to decrease and action potential began to increase 80-90 minutes after UK injection.


CONCLUSIONS
Both intra-arterial thrombolysis and intravenous thrombolysis were effective to the restricted thrombosis in the stria vascularis, and intra-arterial thrombolysis showed a better improvement in the early stage of thrombolysis.
Zhong
Zhen
Z
Department of Otorhinolaryngology Head and Neck Surgery, Peking University First Hospital, Beijing 100034, China. zhong_zhen1973@yahoo.com
Li
Xue-pei
XP
Wu
Hong-tao
HT
D000818:Animals; D003051:Cochlea / Q000098:blood supply; D015834:Cochlear Diseases / Q000188:drug therapy*; D006168:Guinea Pigs; D007269:Injections, Intra-Arterial; D007511:Ischemia / Q000188:drug therapy*; D008297:Male; D008833:Microcirculation; D010960:Plasminogen Activators / Q000008:administration & dosage*; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator