New onset of multiple organ dysfunction after receiving long-term high-dose piperacillin for outpatient treatment of osteomyelitis.
Toxic side effects of piperacillin occur in many organ systems and may be cumulative dose related. We report a patient receiving long-term high-dose piperacillin to accommodate convenient outpatient intravenous therapy of osteomyelitis. He developed life-threatening multiorgan dysfunction on day 20 of piperacillin administration after 49 days of antibiotics, suggesting a likely adverse drug reaction. Piperacillin should be administered according to the manufacturer's recommendations of dosage, frequency and duration, and suggested monitoring. Unorthodox treatment regimens are discouraged.
DeNicola
Lucian K.
LK
University of Florida Health Sciences Center and Wolfson Children's Hospital, Jacksonville, FL; and the Henrietta Egleston Hospital for Children, Atlanta, GA.
Blackwelder
Bryan
B
Khan
Nagma
N