Continuous intraarterial infusion of protease inhibitors in acute pancreatitis.
Low-molecular-weight protease inhibitors were synthesized and developed in Japan and are in clinical use there for the treatment of acute pancreatitis. However, protease inhibitors are not acknowledged as drugs for the treatment of pancreatitis in other countries. In a recent study in 30 patients with necrotizing pancreatitis, survival rate was improved (mortality rate 13.3%) by continuous intraarterial administration of low-molecular-weight protease inhibitors as compared to conventional treatment. In Italy it was reported that pancreatic disorder decreased after the administration of low-molecular-weight protease inhibitors before the start of endoscopic retrograde cholangiopancreatography. Low-molecular-weight protease inhibitors may be potential alternative drugs for the treatment and/or prevention of acute pancreatitis and, therefore, warrant further evaluation. (c) 2001 Prous Science. All rights reserved.
Komoriyama
Hiroyuki
H
Department of Surgery, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Japan.
Tanaka
Ichiro
I
Ikezawa
Hiroyushi
H
Kanasugi
Kazuo
K
Hagiwara
Masaru
M
Yamaguchi
Susumu
S