[Assessment of adherence to antiretroviral: role of determination of plasma levels of non nucleosides anologues].
OBJECTIVE
Our purpose was to assess the contribution of efavirenz and nevirapine plasma concentrations in the assessment of self-reported adherence and punctuality of appointments to take the drugs.


METHODS
Adherence was assessed using questionnaires and plasma concentrations of efavirenz and nevirapine were determined. Patients received efavirenz or nevirapine in combination with two nucleotides reverse transcriptase inhibitors.


RESULTS
Among the 45 enrolled patients, 7 were considered non-adherent according to the questionnaires, 17 regarding pharmacy appointments and 5 according to the plasma levels of efavirenz and nevirapine. 3.3% participants had detectable viral loads.


CONCLUSIONS
Cross-validation between patients'self-reports and pharmacy appointments can improve the measurement of adherence to antiretroviral therapy.
Pérez-Simón
María Rosario
MR
Servicio de Medicina Interna II. Hospital de León. Spain.
Cuevas
María José
MJ
Ortega
Luis
L
Carro
José Antonio
JA
Mostaza
José Luis
JL
Martín
Vicente
V
D000328:Adult; D000480:Alkynes; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D048588:Benzoxazines; D003430:Cross-Sectional Studies; D003521:Cyclopropanes; D005260:Female; D006679:HIV Seropositivity / Q000188:drug therapy*; D006801:Humans; D008297:Male; D019829:Nevirapine / Q000097:blood / Q000627:therapeutic use*; D010078:Oxazines / Q000097:blood / Q000627:therapeutic use*; D010349:Patient Compliance / Q000706:statistics & numerical data*; D015203:Reproducibility of Results; D012647:Self-Assessment; D011795:Surveys and Questionnaires
D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D010078:Oxazines; D019829:Nevirapine; C098320:efavirenz