Transplantation of the uterus.
Most women with uterine factor infertility have today no prospect of carrying a pregnancy to term. The development of a method for transplantation of the human uterus would be a means for many of these women to become both genetic and gestational mothers. In this article we review the literature concerning the history and recent development in the area of uterine transplantation. We describe our newly developed model for heterotopic uterine transplantation in the mouse, which we are using for studies of pregnancy outcome and rejection mechanisms. We also address some of the specific questions that need to be solved before attempts to transplant the human uterus should be performed.
Brännström
Mats
M
Department of Obstetrics and Gynecology, The Sahlgrenska Academy at Göteborg University, Sahlgrenska University Hospital, S-4313 45 Gothenburg, Sweden. mats.brannstrom@obgyn.gu.se
Wranning
Caiza Almén
CA
Racho El-Akouri
Randa
R
D000818:Animals; D005260:Female; D006084:Graft Rejection; D049673:History, 20th Century; D006801:Humans; D007165:Immunosuppression Therapy; D007247:Infertility, Female / Q000601:surgery; D051379:Mice; D023421:Models, Animal; D009926:Organ Preservation; D011247:Pregnancy; D011256:Pregnancy Outcome; D014019:Tissue Donors; D016042:Transplantation, Heterotopic; D014599:Uterus / Q000637:transplantation*