title: Lack of vancomycin tolerance in Streptococcus pneumoniae strains isolated in Barcelona, Spain, from 1999 to 2001.
abstract: To evaluate the incidence of vancomycin tolerance among Streptococcus pneumoniae isolates, we performed killing curve studies with 633 isolates. The penicillin MIC was > or = 0.12 mg/liter for 481 (76%) of the isolates. All strains were susceptible to vancomycin. Killing curve studies were performed with a vancomycin concentration of 2.5 mg/liter. The Tupelo strain was used for quality control. No vancomycin-tolerant strain was detected.
authors.affiliation: Infectious Diseases Unit, Institute of Infectious Diseases and Immunology, Hospital Clínic, Barcelona, Spain. marortegaromero@yahoo.es
authors.forename: Mar
authors.initials: M
authors.lastname: Ortega
authors.forename: Francesc
authors.initials: F
authors.lastname: Marco
authors.forename: Alex
authors.initials: A
authors.lastname: Soriano
authors.forename: Elisa
authors.initials: E
authors.lastname: García
authors.forename: José A
authors.initials: JA
authors.lastname: Martínez
authors.forename: Josep
authors.initials: J
authors.lastname: Mensa
mesh_terms: D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D011008:Pneumococcal Infections / Q000382:microbiology; D013030:Spain; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D014640:Vancomycin / Q000494:pharmacology*; D020713:Vancomycin Resistance
chemical_list: D010406:Penicillins; D014640:Vancomycin