title: The Michael addition of indoles to alpha,beta-unsaturated ketones catalyzed by CeCl3.7H2O-NaI combination supported on silica gel.
abstract: Alkylation of indoles by means of the Michael addition has been the subject of a number of investigation. It is well established that regioselectivity in the additions of indoles to electron-deficient alkenes is strongly controlled by the reaction medium. In a continuation of the work on developing greener and cleaner technologies, the cerium(III) chloride heptahydrate and sodium iodide combination supported on silica gel catalyzes the alkylation of various indoles with alpha,beta-unsaturated ketones giving 3-(3-oxoalkyl)indole derivatives in good yields. The substitution on the indole nucleus occurred exclusively at the 3-position, and N-alkylation products have not been observed.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Camerino, via S. Agostino 1, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bartoli
authors.forename: Massimo
authors.initials: M
authors.lastname: Bartolacci
authors.forename: Marcella
authors.initials: M
authors.lastname: Bosco
authors.forename: Gioia
authors.initials: G
authors.lastname: Foglia
authors.forename: Arianna
authors.initials: A
authors.lastname: Giuliani
authors.forename: Enrico
authors.initials: E
authors.lastname: Marcantoni
authors.forename: Letizia
authors.initials: L
authors.lastname: Sambri
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Torregiani