[Gene therapy for myocardial regeneration].
Most of cardiac myocytes have lost their ability to proliferate and differentiate into new myocytes. Therefore, myocyte regeneration and replacement in adult myocardium was thought to be impossible by medical community. However, recent findings in cardiovascular researches provide the possibility that gene therapy and stem cell therapy could have supportive effects on myocyte regeneration and myocardial revascularization in damaged heart. Here, we presented recent progress, especially, in gene therapy for myocardial regeneration under ischemic heart disease and heart failure.
Hayashi
Shin-ichiro
S
Department of Geriatric Medicine, Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine.
Azuma
Junya
J
Ogihara
Toshio
T
Morishita
Ryuichi
R
D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000166:cytology; D032383:Myocytes, Cardiac / Q000166:cytology / Q000502:physiology*; D018919:Neovascularization, Physiologic; D012038:Regeneration; D033581:Stem Cell Transplantation