title: Vancomycin penetration of uninfected pleural fluid exudate after continuous or intermittent infusion.
abstract: Blood and pleural exudate samples were obtained from 16 patients receiving intermittent or continuous infusions of vancomycin after lung surgery. The areas under the concentration-time curves for blood and pleural exudates were identical for both administration schedules, while continuous infusion allowed the concentrations in pleural exudates to be more sustained (mean concentration, 12 mg/liter).
authors.affiliation: Infectious Diseases Clinic, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium. baudouin.byl@ulb.ac.be
authors.forename: Baudouin
authors.initials: B
authors.lastname: Byl
authors.forename: Frédérique
authors.initials: F
authors.lastname: Jacobs
authors.forename: Pierre
authors.initials: P
authors.lastname: Wallemacq
authors.forename: Camelia
authors.initials: C
authors.lastname: Rossi
authors.forename: Philippe
authors.initials: P
authors.lastname: de Francquen
authors.forename: Matteo
authors.initials: M
authors.lastname: Cappello
authors.forename: Teresinha
authors.initials: T
authors.lastname: Leal
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Thys
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001984:Bronchial Neoplasms / Q000188:drug therapy / Q000378:metabolism; D004334:Drug Administration Schedule; D005122:Exudates and Transudates / Q000378:metabolism; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D016066:Pleural Effusion, Malignant / Q000378:metabolism*; D014640:Vancomycin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin