Digoxin-carvedilol interactions in children.
Digoxin is often coadministered with carvedilol in children with severe ventricular failure. In eight children (age 2 weeks to 8 years), the oral clearance of digoxin decreased by half with carvedilol, and two of them had digoxin toxicity. Carvedilol increases serum concentrations of digoxin in children, and its dose may need to be reduced to avoid toxicity.
Ratnapalan
Savithiri
S
Division of Clinical Pharmacology/Toxicology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Griffiths
Kathryn
K
Costei
Adriana Moldovan
AM
Benson
Lee
L
Koren
Gideon
G
D002227:Carbazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy*; D002316:Cardiotonic Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000077261:Carvedilol; D002648:Child; D002675:Child, Preschool; D004077:Digoxin / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000188:drug therapy*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011412:Propanolamines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*
D002227:Carbazoles; D002316:Cardiotonic Agents; D011412:Propanolamines; D014665:Vasodilator Agents; D000077261:Carvedilol; D004077:Digoxin