title: Hemoglobinopathies among five major ethnic groups in Karachi, Pakistan.
abstract: A brief survey of abnormal hemoglobin variants among the major ethnic groups of Karachi was conducted; 202,600 subjects were studied. Patients with low hemoglobin (Hb), low mean cell volume (MCV) and mean cell hemoglobin (MCH) including anemia, microcytosis, hypochromic hemolysis and target cells, were refered for the identification of hemoglobinopathy by molecular methods. Population screening showed that 60% had iron-deficiency anemia and 40% had hemolytic anemia, of which 20.6% was due to beta-thalassemia major, 13% beta-thalassemia trait, 5.1% sickle cell disease, 0.76% hemoglobin D Punjab (HbD Punjab), 0.32% hemoglobin C (HbC), and 0.22% hereditary persistence of fetal hemoglobin (HPFH).
authors.affiliation: Department of Biochemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Rubina
authors.initials: R
authors.lastname: Ghani
authors.forename: Mehdi A
authors.initials: MA
authors.lastname: Manji
authors.forename: Nikhat
authors.initials: N
authors.lastname: Ahmed
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000208:ethnology* / Q000235:genetics; D000755:Anemia, Sickle Cell / Q000097:blood / Q000208:ethnology* / Q000235:genetics; D004641:Emigration and Immigration; D019353:Endemic Diseases / Q000706:statistics & numerical data; D004909:Erythrocyte Indices; D005319:Fetal Hemoglobin; D005838:Genotype; D006445:Hemoglobin C Disease / Q000097:blood / Q000208:ethnology* / Q000235:genetics; D006453:Hemoglobinopathies / Q000097:blood / Q000208:ethnology* / Q000235:genetics; D006455:Hemoglobins, Abnormal; D006579:Heterozygote; D006801:Humans; D008288:Malaria / Q000453:epidemiology; D008403:Mass Screening; D017720:Molecular Epidemiology; D009154:Mutation / Q000235:genetics; D010154:Pakistan / Q000453:epidemiology; D010641:Phenotype; D011159:Population Surveillance; D015995:Prevalence; D012805:Sickle Cell Trait / Q000097:blood / Q000208:ethnology* / Q000235:genetics; D011795:Surveys and Questionnaires; D014504:Urban Health / Q000706:statistics & numerical data; D017085:alpha-Thalassemia / Q000097:blood / Q000208:ethnology* / Q000235:genetics; D017086:beta-Thalassemia / Q000097:blood / Q000208:ethnology* / Q000235:genetics
chemical_list: D006455:Hemoglobins, Abnormal; C026237:hemoglobin D Punjab; D005319:Fetal Hemoglobin