title: Management of severely immunocompromised human immunodeficiency virus type 1-infected African orphans with structured treatment interruption: another kind of salvage therapy.
abstract: Without an effective therapeutic human immunodeficiency virus (HIV)-1 vaccine, providing cost-effective, minimally toxic antiretroviral therapy to the many individuals already infected with HIV-1 is a global priority. Implementation of a structured treatment interruption (STI) regimen may be a promising intervention for HIV-1 infection. We adopted this approach out of necessity for 3 severely immunocompromised African children naive to therapy, and increases in the T lymphocyte count and improved quality and sustainability of life 2 years after initiation of the STI regimen were noted.
authors.affiliation: Paediatric Infectious Diseases Unit, St. George's Hospital and Medical School, London, United Kingdom. ranachakraborty@hotmail.com
authors.forename: Rana
authors.initials: R
authors.lastname: Chakraborty
authors.forename: Rachel
authors.initials: R
authors.lastname: Musoke
authors.forename: Tresa
authors.initials: T
authors.lastname: Palakudy
authors.forename: Alexandra
authors.initials: A
authors.lastname: Cross
authors.forename: Angelo
authors.initials: A
authors.lastname: D'Agostino
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D002648:Child; D002675:Child, Preschool; D015224:Dideoxynucleosides / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004797:Enzyme-Linked Immunosorbent Assay; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D015497:HIV-1; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D018655:Lymphocyte Count; D016879:Salvage Therapy; D015215:Zidovudine / Q000627:therapeutic use; D000099227:Abacavir
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D019259:Lamivudine; D015215:Zidovudine; D000099227:Abacavir