[Changes of dehydroandrographolide's contents of andrographis tablet in the process of production].
OBJECTIVE
To recognize changes in the contents of ingredients of Andrographis Tablet in the process of production.


METHODS
Adopting TLCS, TLC, HPLC to detect effective contents of ingredients which are produced in every stage of process of Andrographis Table's production.


RESULTS
Handling with the fresh Herba Andrographis according to current pharmacopeoia's technology, it showed that only dehyandrographolide can be detected. It indicated that the main factor that leads to chemical change is the heating process in the process of production.


CONCLUSIONS
Avoiding heating treatment or reducing heating treatment time is the main factor to protect the effective ingredients.
Huang
Xiao-dan
XD
Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, Guangdong, China. helloxiaodan@yahoo.com
Su
Zi-ren
ZR
Lai
Xiao-ping
XP
Lin
Shu-hai
SH
Dong
Xiao-bing
XB
Liu
Zhong-qiu
ZQ
Xie
Pei-shan
PS
D035685:Andrographis / Q000737:chemistry*; D004224:Diterpenes / Q000032:analysis*; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D006358:Hot Temperature; D035261:Plant Components, Aerial / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods
D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D013607:Tablets; C030419:andrographolide; C478098:dehydroandrographolide