title: Plasma oxidative parameters and mortality in patients with severe burn injury.
abstract: OBJECTIVE
  To determine xanthine oxidase and superoxide dismutase activities, lipid peroxidation, protein carbonylation, and total radical-trapping antioxidant parameter in survivors and nonsurvivors patients with severe burn injury.
  
  
  METHODS
  Prospective, comparative observational study in an intensive care unit, burn division, in a trauma hospital.
  
  
  METHODS
  Twenty-five consecutive patients who met the established criteria for severe burn injury (total burn surface area of more than 30%).
  
  
  RESULTS
  Plasma thiobarbituric acid reactive species and protein carbonyls levels were significantly higher in nonsurvivors than in survivors at 0 and 6 h. Elevated xanthine oxidase activity at 0 h was associated with adverse outcome after burn injury. In contrast, plasma superoxide dismutase activity and total radical-trapping antioxidant parameter did not differ significantly between nonsurvivors and survivors at any time point.
  
  
  CONCLUSIONS
  For the first time we demonstrate the value of oxidative parameters, namely thiobarbituric acid reactive species, protein carbonyls, and xanthine oxidase activity, in identifying burn patients with a poor prognosis. Whether these parameters are merely markers of clinical course, or whether they signal specific deleterious effects of oxidative stress during the burn injury remains to be elucidated.
authors.affiliation: Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 anexo, 90035-003, Porto Alegre, RS, Brazil.
authors.forename: Cristiane
authors.initials: C
authors.lastname: Ritter
authors.forename: Michael
authors.initials: M
authors.lastname: Andrades
authors.forename: Márcio
authors.initials: M
authors.lastname: Guerreiro
authors.forename: Leonardo
authors.initials: L
authors.lastname: Zavaschi
authors.forename: Daniel Pens
authors.initials: DP
authors.lastname: Gelain
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Souza
authors.forename: Cyntia A
authors.initials: CA
authors.lastname: Ribeiro
authors.forename: Nadine
authors.initials: N
authors.lastname: Clausell
authors.forename: Sérgio
authors.initials: S
authors.lastname: Menna-Barreto
authors.forename: José Cláudio F
authors.initials: JC
authors.lastname: Moreira
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
mesh_terms: D000328:Adult; D015415:Biomarkers; D001798:Blood Proteins / Q000378:metabolism; D002056:Burns / Q000097:blood* / Q000401:mortality*; D003422:Critical Care; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D010084:Oxidation-Reduction; D011379:Prognosis; D011446:Prospective Studies; D013482:Superoxide Dismutase / Q000097:blood*; D013858:Thiobarbiturates / Q000097:blood*; D014969:Xanthine Oxidase / Q000097:blood*
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D013858:Thiobarbiturates; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; C029684:thiobarbituric acid