Inflammation in Parkinson's disease.
Several studies of Parkinson's disease (PD) patients and experimental models of PD indicate the presence of an inflammatory process in PD. Although the primary cellular mechanisms remain to be clarified, activation of resident microglia appears to aggravate or even maintain the disease process in PD. Modulation of inflammatory mechanisms could provide a new neuroprotective therapy in PD.
Wüllner
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Department of Neurology, University Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. wuellner@uni-bonn.de
Klockgether
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D000818:Animals; D002490:Central Nervous System / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D010300:Parkinson Disease / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D010525:Peripheral Nerves / Q000276:immunology