title: [Regulation of NF-kappa B activity].
abstract: Nuclear factor kappa B (NF-kappa B) is common proinflammatory transcription factor involved in expression of c.a. 300 different genes. It is usually present in the cytosol as an inactive complex and upon activation translocates into the nucleus. The mechanisms of activation of NF-kappa B are complex and they involve several different signaling pathways and plethora of proteins. In this minireview we describe the main deciphered as well as suggested mechanisms regulating of NF-kappa B activity.
authors.affiliation: Laboratorium Białek Sygnałowych Instytutu Immunologii i Terapii Doświadczalnej PAN im. L. Hirszfelda we Wrocławiu. siednienko@immuno.iitd.pan.wroc.pl
authors.forename: Jakub
authors.initials: J
authors.lastname: Siednienko
authors.forename: Wojciech A
authors.initials: WA
authors.lastname: Gorczyca
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D007375:Interleukin-1; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha