Increased zinc finger protein zFOC1 transcripts in gastric cancer compared with normal gastric tissue.
BACKGROUND
Screening of cDNA arrays of the IMAGE library identified human zFOC1 as a differentially expressed cDNA that was upregulated in KATO III gastric cancer cells following stimulation with the gastric pathogen Helicobacter pylori.


OBJECTIVE
To determine the expression of zFOC1 in gastric mucosa with and without H pylori infection and in patients with gastric cancer.


RESULTS
zFOC1 is localised on chromosome 12q24.3 and encodes a zinc finger protein. Expression studies in human H pylori infected and uninfected gastric biopsies, gastric tumours, and gastric cancer cell lines revealed that zFOCI gene transcripts are significantly higher in gastric cancer than in non-cancerous gastric tissues.


CONCLUSIONS
The zFOC1 gene appears to be a tumour marker associated with gastric cancer.
Stephen
R L
RL
Molecular Medicine Unit, St James's University Hospital, Leeds LS9 7TF, West Yorkshire, UK.
Crabtree
J E
JE
Yoshimura
T
T
Clayton
C L
CL
Dixon
M F
MF
Robinson
P A
PA
D000595:Amino Acid Sequence; D014408:Biomarkers, Tumor / Q000235:genetics*; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000235:genetics*; D019143:Evolution, Molecular; D005753:Gastric Mucosa / Q000378:metabolism* / Q000382:microbiology; D020869:Gene Expression Profiling; D016481:Helicobacter Infections / Q000235:genetics; D016480:Helicobacter pylori; D006801:Humans; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D015854:Up-Regulation; D016335:Zinc Fingers
D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D014157:Transcription Factors; C099572:ZNF664 protein, human