title: [Osteopontin and arthritis].
abstract: Osteopontin is an RGDS-containing protein which acts as an intercellular signaling molecule as well as a cellular attachment protein. Expression of osteopontin has been observed in the joints of patients with rheumatoid arthritis as well as osteoarthritis. However, the functions of osteopontin in such diseased articular components have not yet been elucidated. Recent investigations using knockout mice lacking osteopontin indicated that the presence of osteopontin could play a role in the development of arthritis induced by injection with monoclonal antibodies raised against type II collagen.
authors.affiliation: Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University.
authors.forename: Masaki
authors.initials: M
authors.lastname: Noda
authors.forename: Kenji
authors.initials: K
authors.lastname: Yumoto
authors.forename: Mikihiko
authors.initials: M
authors.lastname: Morinobu
authors.forename: Kunikazu
authors.initials: K
authors.lastname: Tsuji
authors.forename: Akira
authors.initials: A
authors.lastname: Nifuji
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000209:etiology*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D053495:Osteopontin; D012795:Sialoglycoproteins / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
chemical_list: C506895:SPP1 protein, human; D012795:Sialoglycoproteins; C506896:Spp1 protein, mouse; D053495:Osteopontin