title: Protein transduction technology offers novel therapeutic approach for brain ischemia.
abstract: Transient or permanent reduction in cerebral blood flow following ischemia can lead to severe and irreversible tissue damage to the brain. Emerging biochemical evidence suggests a role for apoptosis in neuronal death following cerebral ischemia. Despite the abundance of studies on the subject, therapeutic interventions for ischemia-related cell injury have so far proved disappointing in clinical trials. Recently, four new, exciting studies reported the use of protein transduction technology to deliver anti-apoptotic molecules to protect neuronal cells following ischemic stroke in vivo. These studies offer new avenues for the treatment and prevention of cell death following brain injuries.
authors.affiliation: Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, University of California San Diego School of Medicine, La Jolla 92093-0686, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Denicourt
authors.forename: Steven F
authors.initials: SF
authors.lastname: Dowdy
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D014161:Transduction, Genetic
chemical_list: D011506:Proteins