title: Combined serum and ultrasound screening for detection of fetal aneuploidy.
abstract: Experience gathered over the last decade from high-risk centers provide strong evidence that mid-trimester sonographic markers are sensitive for Down syndrome prediction. More recent data indicate that combining mid trimester sonography with traditional serum markers significantly improves diagnostic accuracy over either group of markers by themselves.
authors.affiliation: Department of Obstetrics and Gynecology, University of Cincinnati, OH 45267-0526, USA.
authors.forename: Ray
authors.initials: R
authors.lastname: Bahado-Singh
authors.forename: Chih-Chien
authors.initials: CC
authors.lastname: Cheng
authors.forename: Paul
authors.initials: P
authors.lastname: Matta
authors.forename: Maria
authors.initials: M
authors.lastname: Small
authors.forename: Maurice J
authors.initials: MJ
authors.lastname: Mahoney
mesh_terms: D000782:Aneuploidy; D006063:Chorionic Gonadotropin / Q000097:blood; D002882:Chromosomes, Human, Pair 13; D002887:Chromosomes, Human, Pair 18; D004314:Down Syndrome / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000235:genetics*; D005260:Female; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011262:Pregnancy Trimester, Second; D016216:Ultrasonography, Prenatal / Q000379:methods*; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins