title: [Assessment of adherence to antiretroviral: role of determination of plasma levels of non nucleosides anologues].
abstract: OBJECTIVE
  Our purpose was to assess the contribution of efavirenz and nevirapine plasma concentrations in the assessment of self-reported adherence and punctuality of appointments to take the drugs.
  
  
  METHODS
  Adherence was assessed using questionnaires and plasma concentrations of efavirenz and nevirapine were determined. Patients received efavirenz or nevirapine in combination with two nucleotides reverse transcriptase inhibitors.
  
  
  RESULTS
  Among the 45 enrolled patients, 7 were considered non-adherent according to the questionnaires, 17 regarding pharmacy appointments and 5 according to the plasma levels of efavirenz and nevirapine. 3.3% participants had detectable viral loads.
  
  
  CONCLUSIONS
  Cross-validation between patients'self-reports and pharmacy appointments can improve the measurement of adherence to antiretroviral therapy.
authors.affiliation: Servicio de Medicina Interna II. Hospital de León. Spain.
authors.forename: María Rosario
authors.initials: MR
authors.lastname: Pérez-Simón
authors.forename: María José
authors.initials: MJ
authors.lastname: Cuevas
authors.forename: Luis
authors.initials: L
authors.lastname: Ortega
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Carro
authors.forename: José Luis
authors.initials: JL
authors.lastname: Mostaza
authors.forename: Vicente
authors.initials: V
authors.lastname: Martín
mesh_terms: D000328:Adult; D000480:Alkynes; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D048588:Benzoxazines; D003430:Cross-Sectional Studies; D003521:Cyclopropanes; D005260:Female; D006679:HIV Seropositivity / Q000188:drug therapy*; D006801:Humans; D008297:Male; D019829:Nevirapine / Q000097:blood / Q000627:therapeutic use*; D010078:Oxazines / Q000097:blood / Q000627:therapeutic use*; D010349:Patient Compliance / Q000706:statistics & numerical data*; D015203:Reproducibility of Results; D012647:Self-Assessment; D011795:Surveys and Questionnaires
chemical_list: D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D010078:Oxazines; D019829:Nevirapine; C098320:efavirenz