title: Molecular genetic events in adult acute lymphoblastic leukemia.
abstract: Treatment of acute lymphoblastic leukemia in adults focuses on the initial assessment of prognostic relevant genetic features as well as response-guided therapy based on molecular data. In at least half of adult acute lymphoblastic leukemia patients, clonal chromosomal abnormalities can be identified that deregulate candidate oncogenes or transcription factors by introducing a heterologous promoter or enhancer. Altered cell cycle progression or upregulated tyrosine kinase activity are other important mechanisms. Most of the translocations can lead to the generation of fusion genes that are translated into chimeric oncogeneic proteins, such as BCR-ABL, providing targets for novel therapeutic agents.
authors.affiliation: Department of Medicine, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany. gleisner@zedat.fu-berlin.de
authors.forename: Beate
authors.initials: B
authors.lastname: Gleissner
authors.forename: Eckhard
authors.initials: E
authors.lastname: Thiel
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor; D002869:Chromosome Aberrations; D017353:Gene Deletion; D006801:Humans; D009154:Mutation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor