Placental and fetal toxicity of albendazole sulphoxide in Wistar rats.
This work characterized the effects of albendazole sulphoxide (ABZSO) on placental and fetal parameters in Wistar rats on day 20 of gestation. ABZSO was fed in laboratory chow at 0, 2.5, 5, 10, 20 or 30 mg/kg/d from day 6 to 15 of gestation to pregnant rats. Data of resorptions, placental and fetal characteristics and fetal skeletal malformations were recorded. Resorption percentages in the 20 and 30 mg/kg/d groups were significantly higher compared to the control group. Placentas of ABZSO-treated rats had lower weight and smaller size than untreated rats. The fetal weight and size were lower in the 5 mg/kg/d dose compared to no treatment. In the 5, 10 and 20 mg/kg/d groups, reductions in ossification process were observed. ABZSO induced malformations and/or fetal death when orally administered to pregnant rats. This data contributes to characterization of the reproductive toxicity of ABZSO, the main active metabolite of albendazole.
Teruel
Miriam T
MT
Lab. de Embriología, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina.
Felipe
Antonio E
AE
Solana
Hugo D
HD
Sallovitz
Juan M
JM
Lanusse
Carlos E
CE
D000015:Abnormalities, Multiple / Q000139:chemically induced / Q000662:veterinary; D000284:Administration, Oral; D015766:Albendazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity*; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005333:Fetus / Q000187:drug effects*; D017880:Limb Deformities, Congenital / Q000139:chemically induced / Q000662:veterinary; D010920:Placenta / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D000871:Anthelmintics; D015766:Albendazole; C027186:albendazole sulfoxide