Coagulation and fibrinolytic activity in patients with acute cerebral infarction.
OBJECTIVE
To measure the concentration of D-dimer (DD), tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1) and plasminogen (PLG) activity in plasma and cerebrospinal fluid in patients with acute cerebral infarction and to investigate their clinical significance.


METHODS
The concentrations of D-dimer, t-PA, and PAI-1 in plasma and cerebrospinal fluid in patients were measured by enzyme-linked immunosorbent assay (ELISA). The PLG biological activity was detected using the chromophore method. The results were compared with those of the controls.


RESULTS
The concentrations of D-dimer, t-PA and PAI-1 in cerebrospinal fluid and plasma in patients with acute cerebral infarction were much higher than those of normal subjects (P < 0.01). Conversely, the level of PLG activity was significantly lower in the patients than in the controls (P < 0.01).


CONCLUSIONS
Hypercoagulability and secondary hyperfibrinolysis exist in patients with acute cerebral infarction.
Li
Feng
F
Department of Neurology, People's Hospital, Wuhan University, Wuhan 430060, China. gylfsd@yahoo.com.cn
Zhang
Guibin
G
Zhao
Wenzhou
W
D000208:Acute Disease; D000368:Aged; D001777:Blood Coagulation; D002544:Cerebral Infarction / Q000097:blood*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis / Q000134:cerebrospinal fluid; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000032:analysis / Q000134:cerebrospinal fluid; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood / Q000134:cerebrospinal fluid; D010959:Tissue Plasminogen Activator / Q000097:blood / Q000134:cerebrospinal fluid
D005338:Fibrin Fibrinogen Degradation Products; D017395:Plasminogen Activator Inhibitor 1; C036309:fibrin fragment D; D010958:Plasminogen; D010959:Tissue Plasminogen Activator