[Relationship between apolipoprotein E and apolipoprotein B polymorphisms in youths with coronary heart disease].
OBJECTIVE
To investigate hereditary susceptibility to coronary heart disease (CHD) in apolipoprotein E(apo E) and apo B polymorphisms of youths.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze apoE, apoB Xba I, apoB 3' variable number of tandem repeat (VNTR) genotypes for 244 healthy Han students (among them were 109 students with positive CHD family history).


RESULTS
The allele frequencies of apo e4, XbaI x(+), 3'VNTR-B(hypervariable element, HVE>38) in the positive group were obviously higher than those in the negative group(P<0.05), and were significantly correlated with the increase in TC, LDL-C, apoB100 levels (P<0.05).


CONCLUSIONS
The alleles for apo e4, XbaI x(+), 3'VNTR-B may be the important genetic markers of Han CHD.
Li
Sha
S
Dongshan People's Hospital of Guangzhou, Guangzhou,Guangdong, 510080PR China. lisha1921@sina.com
Lei
Zhao-wen
ZW
Chen
Zili
Z
Lin
Da
D
Ke
Xi-song
XS
Zhong
Yao-ming
YM
Wu
Su-fen
SF
D000293:Adolescent; D000483:Alleles; D001055:Apolipoproteins B / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D055815:Young Adult
D001055:Apolipoproteins B; D001057:Apolipoproteins E