title: [Onchocerciasis].
abstract: Onchocerciasis is an infestation caused by the nematode, Onchocerca volvulus, and characterized by eye manifestations, skin lesions and troublesome itching. Although partially controlled by international mass treatment programs, onchocerciasis remains a major health hazard in endemic areas in Africa, Arabia, and the Americas. Onchocerciasis is spread by bites from infested blackflies which transmit larvae that subsequently develop into adult filariae. Skin findings are commonly non-specific, and include severe pruritus, acute and chronic dermatitis, vitiligo-like hypopigmentation and atrophy. Onchocercal ocular disease has a large spectrum of manifestations and may even lead to blindness. Diagnosis is usually made by direct visualization of the larvae emerging from superficial skin biopsies, "skin snips". In some cases, the microfilariae can also be directly observed with a slit lamp when they migrate into the anterior chamber of the eye. Ivermectin is highly microfilaricidal, and is the current drug of choice for both skin and ocular manifestations.
authors.affiliation: The Hadassah-Germany Skin Center, Department of Dermatology, The Hebrew University Medical School, Jerusalem, Israel. enk@hadassah.org.il
authors.forename: C D
authors.initials: CD
authors.lastname: Enk
authors.forename: K
authors.initials: K
authors.lastname: Gardlo
authors.forename: T
authors.initials: T
authors.lastname: Ruzicka
authors.forename: D
authors.initials: D
authors.lastname: BenEzra
mesh_terms: D000969:Antinematodal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000977:Antiparasitic Agents; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use; D009855:Onchocerciasis / Q000175:diagnosis / Q000188:drug therapy; D015827:Onchocerciasis, Ocular / Q000175:diagnosis / Q000188:drug therapy; D012867:Skin / Q000473:pathology; D012876:Skin Diseases, Parasitic / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D013997:Time Factors
chemical_list: D000969:Antinematodal Agents; D000977:Antiparasitic Agents; D007559:Ivermectin