[The role of neuronal nicotinic acetylcholine receptors in the mechanisms of general anesthesia].
Neuronal nicotinic acetylcholine receptors (nnAChRs) are members of the ligand-gated ion channel superfamily, and widely expressed in the central and peripheral nervous systems with many subunits. NnAChRs have been represented novel targets for a wide variety of therapeutic agents based on their complex functions. It is known that both central and peripheral nnAChRs are sensitive to various types of general anesthetics, among those, barbiturates, ketamine, volatile and gaseous anesthetics depress nnAChRs at or below clinical concentrations. It is possible that inhibition of nnAChRs is one of factors involved in the mechanisms of general anesthesia.
Xue
Qing-Sheng
QS
Department of Anesthesiology, Ruijin Hospital, Shanghai 200025.
Yu
Bu-Wei
BW
D000768:Anesthesia, General; D018681:Anesthetics, General / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D051381:Rats; D011978:Receptors, Nicotinic / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*
D018681:Anesthetics, General; D011978:Receptors, Nicotinic