title: [Effect of staphylococcal enterotoxin B on ion electrophysiology and permeability in rabbit maxillary sinus epithelium].
abstract: OBJECTIVE
  To study the barrier role of staphylococcal enterotoxin B (SEB) in rabbit maxillary sinus mucosa.
  
  
  METHODS
  Rabbit maxillary sinus mucosal membrane was dissected under a surgical microscope. The short-circuit current (Isc), conductance (G) and its permeability to horseradish peroxidase (HRP) were evaluated by employing Ussing chamber technique.
  
  
  RESULTS
  The stimulation of SEB enhanced Isc, G and its permeability to HRP of sinus epithelial barrier. The same results were obtained by applying tumor necrosis factor alpha (TNF-alpha) to rabbit maxillary sinus. Increase in TNF-alpha level in sinus mucosa was observed by the stimulation of SEB. Those pathophysiological abnormalities of sinus mucosa were abolished by pretreatment with anti-TNF-alpha antibody.
  
  
  CONCLUSIONS
  The SEB has potential effects on rabbit maxillary sinus mucosal barrier, activates the immune cells in the mucosa, and plays certain roles in maxillary sinusitis.
authors.affiliation: Department of Otorhinolaryngology, First Hospital, Shanxi Medical University, Taiyuan 030001, China. lqy90326@public.ty.sx.cn
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.forename: Pingchang
authors.initials: P
authors.lastname: Yang
authors.forename: Binquan
authors.initials: B
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Huangfu
authors.forename: Nianzu
authors.initials: N
authors.lastname: Zhang
authors.forename: Lijun
authors.initials: L
authors.lastname: Xia
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004594:Electrophysiology; D004768:Enterotoxins / Q000494:pharmacology*; D008443:Maxillary Sinus / Q000187:drug effects* / Q000502:physiology; D009092:Mucous Membrane / Q000187:drug effects*; D011817:Rabbits; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D004768:Enterotoxins; D014409:Tumor Necrosis Factor-alpha; C031818:enterotoxin B, staphylococcal