title: [Value of the uCyt+ test for the detection and followup of bladder tumors].
abstract: BACKGROUND
  Superficial bladder tumours are common tumours that frequently relapse, generally with deterioration of the grade. Cystoscopic surveillance is unpleasant for the patient and is associated with considerable morbidity, while urine cytology, although very easy to poor, has a low sensitivity. According to the literature, the uCyt+ test is very effective for the detection of urothelial tumours. This immunofluorescent technique detects desquamated tumour cells previously labelled by specific antibodies.
  
  
  METHODS
  This prospective study was conducted in 92 patients undergoing screening or follow-up cystoscopy. Voided urine was collected prior to cystoscopy to perform standard cytology and a uCyt+ test. These examinations were interpreted independently under blinded conditions.
  
  
  RESULTS
  The sensitivity and specificity of uCyt+ were 68.7% and 81.7%, versus 40.6% and 96.7% for cytology. The sensitivity of uCyt+ was higher for low-grade tumours (87.5%), in contrast with cytology (37.5%). The results of uCyt+ were comparable to those of cytology for high-grade tumours (80%).
  
  
  CONCLUSIONS
  The uCyt+ test presented better performances than standard cytology. It would allow less frequent surveillance cystoscopy examinations, especially in patients with low-grade lesions.
authors.affiliation: Service d'Urologie, Hôtel Dieu, 1, place Alexis Ricordeau, 44093 Nantes, France. eric.drapier@free.fr
authors.forename: Eric
authors.initials: E
authors.lastname: Drapier
authors.forename: Karine
authors.initials: K
authors.lastname: Renaudin
authors.forename: Frédéric
authors.initials: F
authors.lastname: Maillet
authors.forename: Guillaume
authors.initials: G
authors.lastname: Braud
authors.forename: Christian
authors.initials: C
authors.lastname: Laboisse
authors.forename: Olivier
authors.initials: O
authors.lastname: Bouchot
mesh_terms: D003558:Cystoscopy / Q000379:methods; D005455:Fluorescent Antibody Technique; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000652:urine; D014556:Urine / Q000166:cytology*