[Effects of rhidosin on expression of fibroblast growth factor on olfactory bulb in senile rats and its significance].
OBJECTIVE
To discuss the effects of rhidosin on expression of fibroblast growth factor (FGF) on olfactory bulb in senile rats and its significance.


METHODS
Ten rats each were used in the rhidosin group and physiological saline control group. After decapitation, the olfactory mucosa and olfactory bulbs were immediately fixed with neutral formalin, followed with paraffin-embedding, serial sectioning, immunohistochemical staining and light microscopic observation.


RESULTS
The positive expression rate of FGF on olfactory bulb in the rhidosin group was significantly higher than that in the physiological saline control group (P < 0.01). No positive expression of FGF on olfactory mucosa was observed in these two groups.


CONCLUSIONS
Rhidosin can increase the expression of FGF on olfactory bulbs in senile rats and these may be one of the mechanisms by which rhidosin exerts its anti-aging effects on the olfactory system.
Guan
G
G
Department of Otorhinolaryngology & Head and Neck Surgery, Third Teaching Hospital, Bethune University of Medical Sciences, Changchun 130031.
Wang
Y
Y
Dong
Z
Z
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005346:Fibroblast Growth Factors / Q000096:biosynthesis*; D007273:Injections, Intramuscular; D008297:Male; D009830:Olfactory Bulb / Q000187:drug effects* / Q000378:metabolism; D009831:Olfactory Mucosa / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D005346:Fibroblast Growth Factors