title: Evidence to support the existence of subgroups within the UK epidemic Clostridium difficile strain (PCR ribotype 1).
abstract: We used three different DNA fingerprinting techniques and clindamycin susceptibility testing to confirm that Clostridium difficile PCR ribotype I isolates can be divided into two subclones. This observation may permit a better understanding of the epidemiology and pathogenicity of C. difficile infection.
authors.affiliation: Department of Microbiology, The University of Leeds and Leeds General Infirmary, Old Medical School, Leeds LS2 9JT, UK.
authors.forename: W N
authors.initials: WN
authors.lastname: Fawley
authors.forename: J
authors.initials: J
authors.lastname: Freeman
authors.forename: M H
authors.initials: MH
authors.lastname: Wilcox
mesh_terms: D002981:Clindamycin / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000145:classification / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D003015:Clostridium Infections / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology; D016172:DNA Fingerprinting; D004196:Disease Outbreaks; D004739:England / Q000453:epidemiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D021521:Ribotyping
chemical_list: D002981:Clindamycin