Deficit in long-term contextual fear memory induced by blockade of beta-adrenoceptors in hippocampal CA1 region.
The present study investigated the effects of intra-CA1 infusion of d,l-propranolol, the beta-adrenergic antagonist, on memory for contextual fear conditioning. d,l-Propranolol administered 5 min ('0 h') postconditioning impaired long-term but not short-term contextual fear memory, while it was ineffective when administered 6 h postconditioning, suggesting that there is a time window for beta-adrenoceptors to play a role. Thus, we conclude that beta-adrenoceptors in area CA1 are involved in regulating consolidation of contextual fear memory, with '0 h' but not 6 h post-training, a sensitive time point for the beta-adrenergic involvement.
Ji
Jin-Zhao
JZ
Laboratory of Higher Brain Functions, Institute of Neurobiology, Fudan University, Shanghai 200433, The People's Republic of China.
Wang
Xin-Ming
XM
Li
Bao-Ming
BM
D000319:Adrenergic beta-Antagonists / Q000633:toxicity*; D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology; D005239:Fear / Q000187:drug effects* / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007103:Immobilization / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D008569:Memory Disorders / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011943:Receptors, Adrenergic, beta / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta