title: DNA damage in brain cells of mice treated with an oxidized form of apomorphine.
abstract: We investigated whether systemic injection of apomorphine and its oxidation derivative 8-oxo-apomorphine-semiquinone (8-OASQ) could induce DNA damage in mice brain, using the single-cell gel assay. 8-OASQ induced DNA damage in the brains at 1 and 3 h, but not at 24 h after treatment whereas apomorphine induced a slight increase in brain DNA damage frequency at 3 h after treatment, suggesting that both drugs display genotoxic activity in brain tissue.
authors.affiliation: GENOTOX-Genotoxicity Laboratory, Center for Biotechnology, and Department of Biophysics, Institute of Biosciences, Federal University of Rio Grande do Sul (UFRGS), Av. Bento Gonçalves, 9500, 91501-970, RS, Porto Alegre, Brazil.
authors.forename: Jaqueline Nascimento
authors.initials: JN
authors.lastname: Picada
authors.forename: Debora G
authors.initials: DG
authors.lastname: Flores
authors.forename: Cláudio G
authors.initials: CG
authors.lastname: Zettler
authors.forename: Norma Possa
authors.initials: NP
authors.lastname: Marroni
authors.forename: Rafael
authors.initials: R
authors.lastname: Roesler
authors.forename: João Antonio Pêgas
authors.initials: JA
authors.lastname: Henriques
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000031:analogs & derivatives / Q000633:toxicity*; D001921:Brain / Q000187:drug effects; D020552:Comet Assay; D004249:DNA Damage; D018491:Dopamine Agonists / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D011809:Quinones / Q000633:toxicity*
chemical_list: C470323:8-oxo-apomorphine-semiquinone; D018491:Dopamine Agonists; D011809:Quinones; D001058:Apomorphine