Intracellular sorting and transport of proteins.
The secretory and endocytic pathways of eukaryotic organelles consist of multiple compartments, each with a unique set of proteins and lipids. Specific transport mechanisms are required to direct molecules to defined locations and to ensure that the identity, and hence function, of individual compartments are maintained. The localisation of proteins to specific membranes is complex and involves multiple interactions. The recent dramatic advances in understanding the molecular mechanisms of membrane transport has been due to the application of a multi-disciplinary approach, integrating membrane biology, genetics, imaging, protein and lipid biochemistry and structural biology. The aim of this review is to summarise the general principles of protein sorting in the secretory and endocytic pathways and to highlight the dynamic nature of these processes. The molecular mechanisms involved in this transport along the secretory and endocytic pathways are discussed along with the signals responsible for targeting proteins to different intracellular locations.
van Vliet
Catherine
C
The Russell Grimwade School of Biochemistry and Molecular Biology, University of Melbourne, Victoria 3010, Melbourne, Australia.
Thomas
Elaine C
EC
Merino-Trigo
Ana
A
Teasdale
Rohan D
RD
Gleeson
Paul A
PA
D000818:Animals; D001693:Biological Transport, Active; D004705:Endocytosis / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000502:physiology*; D011992:Endosomes / Q000502:physiology*; D006056:Golgi Apparatus / Q000502:physiology*; D006801:Humans; D042541:Intracellular Space / Q000502:physiology; D021382:Protein Sorting Signals / Q000502:physiology; D021381:Protein Transport / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D021601:trans-Golgi Network / Q000502:physiology
D021382:Protein Sorting Signals; D011506:Proteins