title: Transition from diffuse cellular infiltration to extensive nodular granuloma as a manifestation of isolated sarcoidosis in the hand: a case report.
abstract: A patient with soft-tissue sarcoidosis of the hand is described. She initially presented with diffuse soft-tissue infiltration in the digits. After a 12-year time period without steroid treatment the patient developed extensive, tumor-like nodular masses involving multiple digits with lesions extending to the fingertips. Variable clinical features of the soft-tissue sarcoidosis of the hand have been reported as distinctive, independent manifestations of the disease. A transition from the diffuse cellular infiltration to the nodular, tumor-like lesions in the present case shows that the isolated soft-tissue sarcoidosis of the hand may exhibit variable clinical features in a single case.
authors.affiliation: Department of Orthopaedic Surgery, Shiga University of Medical Science, Shiga-ken, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Imai
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Kubo
authors.forename: Kousei
authors.initials: K
authors.lastname: Andou
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Matsusue
mesh_terms: D005260:Female; D005385:Fingers / Q000473:pathology; D006099:Granuloma / Q000473:pathology*; D006225:Hand; D006801:Humans; D008875:Middle Aged; D012507:Sarcoidosis / Q000473:pathology*; D013583:Synovial Membrane / Q000473:pathology; D013717:Tenosynovitis / Q000473:pathology*