title: How to use nitrates.
abstract: Nitrates are old drugs, available in many formulations, that are effective in relieving symptoms in various CAD syndromes as well as congestive heart failure. Nitrate tolerance is the major problem limiting nitrate efficacy and use by physicians. Currently, an intermittent dosing strategy is the only practical way to limit the development of tolerance or attenuation of nitrate actions.
authors.affiliation: Department of Internal Medicine, The University of New Mexico Health Sciences Center, Division of Cardiology, Albuquerque, NM, USA. JAbrams@salud.unm.edu
authors.forename: Jonathan
authors.initials: J
authors.lastname: Abrams
mesh_terms: D004305:Dose-Response Relationship, Drug; D006801:Humans; D009566:Nitrates / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005996:Nitroglycerin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D014481:United States / Q000453:epidemiology; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D009566:Nitrates; D014665:Vasodilator Agents; D005996:Nitroglycerin