Automated carbohydrate synthesis to drive chemical glycomics.
This feature article describes the development of the first automated solid-phase oligosaccharide synthesizer. A series of chemical challenges had to be addressed to accomplish this breakthrough and provide rapid access to oligosaccharides of biological significance. Accelerated synthesis of glycoconjugates promises to greatly impact the emerging field of glycobiology. Chemical glycomics uses synthetic carbohydrates and analogs to study their role in recognition, signal transduction pathways and other events of fundamental biomedical significance and shapes up to become the next major wave in biomedical research. The automated synthesis of a novel malaria vaccine candidate is discussed to illustrate the medical potential of chemical glycomics.
Seeberger
Peter H
PH
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. seeberg@mit.edu
D001331:Automation / Q000379:methods*; D002240:Carbohydrate Sequence; D006031:Glycosylation; D006801:Humans; D017780:Malaria Vaccines / Q000138:chemical synthesis; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry*
D017780:Malaria Vaccines; D009844:Oligosaccharides