Genetics of hypertension: the adducin paradigm.
The following were investigated: (1) how we became interested in studying adducin genes and what we know about adducin; (2) studies in animals and humans supporting the role of adducin polymorphisms in hypertension, including some methodological problems related to the dissection of the role of a given genetic molecular mechanism in a complex multifactorial polygenic disease like hypertension; (3) biochemical mechanisms underlying the effect of adducin and its interaction with the Na-K pump; and (4) future directions.
Bianchi
Giuseppe
G
Chair and School of Nephrology, Division of Nephrology, Dialysis, and Hypertension, Università Vita e Salute, San Raffaele Hospital, Milan, Italy. bianchi.giuseppe@hsr.it
Tripodi
Grazia
G
D000818:Animals; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D003598:Cytoskeletal Proteins / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D006977:Hypertension, Renal / Q000235:genetics; D051381:Rats; D000099291:Adducins
D002148:Calmodulin-Binding Proteins; D003598:Cytoskeletal Proteins; D000099291:Adducins