title: A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2.
abstract: The extracellular glutathione S-transferase from the filarial parasite Onchocerca volvulus (Ov-GST1) is a glutathione-dependent prostaglandin D synthase. Ov-GST1, located in the outer hypodermal lamellae and in parts of the cuticle, produces prostaglandin D(2) directly at the parasite-host interface. Ov-GST1 therefore has the potential to participate in the modulation of the host immune response by contributing to the production of prostanoids; this supports the predominant hypothesis that parasite-derived eicosanoids influence host inflammatory and immune cells.
authors.affiliation: Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Sommer
authors.forename: Rainer
authors.initials: R
authors.lastname: Rickert
authors.forename: Peter
authors.initials: P
authors.lastname: Fischer
authors.forename: Hans
authors.initials: H
authors.lastname: Steinhart
authors.forename: Rolf D
authors.initials: RD
authors.lastname: Walter
authors.forename: Eva
authors.initials: E
authors.lastname: Liebau
mesh_terms: D000818:Animals; D005982:Glutathione Transferase / Q000502:physiology*; D015801:Helminth Proteins / Q000502:physiology*; D019746:Intramolecular Oxidoreductases / Q000502:physiology; D054834:Lipocalins; D017181:Onchocerca volvulus / Q000201:enzymology*; D015230:Prostaglandin D2 / Q000096:biosynthesis*
chemical_list: D015801:Helminth Proteins; D054834:Lipocalins; D005982:Glutathione Transferase; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase; D015230:Prostaglandin D2