[The effect of shourong compound formula on levels of dopamine and its metabolites in brain of Parkinson's disease mice induced by reserpine].
OBJECTIVE
To investigate the effect of Shourong compound formula on treating Parkinson's disease.


METHODS
Parkinson's disease model mice induced by reserpine was used and by HPLC-ED the levels of Dopamine (DA) and its metabolites were determined.


RESULTS
Madopar could increase the levels of DA in brain of PD mice. The effect of madopar together with Sourong compound formula was better than that of madopar(P < 0.001).


CONCLUSIONS
Shourong compound formula together with madopar has synergic effect on increase of DA level in brain and can reduce clinic dose of madopar so that side effect of madopar can be decreased.
Wang
Wei
W
Xiyuan Hospital, China Academy of TCM, Beijing 100091, China.
Zhao
De-zhong
DZ
Sun
Xiao-fang
XF
Gu
Sheng-dong
SD
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001545:Benserazide / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004338:Drug Combinations; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000378:metabolism; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051379:Mice; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012110:Reserpine
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C005177:benserazide, levodopa drug combination; C477182:shourong compound formula; D015102:3,4-Dihydroxyphenylacetic Acid; D007980:Levodopa; D001545:Benserazide; D012110:Reserpine; D004298:Dopamine; D006719:Homovanillic Acid