title: N-ferrocenylmethyl, N'-methyl-2-substituted benzimidazolium iodide salts with in vitro activity against the Leishmania infantum parasite strain L1.
abstract: Herein, we disclose results of our research into a class of benzimidazolium compounds active against the Leishmania infantum parasite strain L1. We have discovered that N-ferrocenylmethyl, N'-methyl-2-aryl (or styryl) benzimidazolium iodide salts show in vitro activity against this strain.
authors.affiliation: School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland. joshua.howarth@dcu.ie
authors.forename: Joshua
authors.initials: J
authors.lastname: Howarth
authors.forename: Keith
authors.initials: K
authors.lastname: Hanlon
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology*; D005296:Ferrous Compounds / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007454:Iodides / Q000737:chemistry / Q000494:pharmacology; D018314:Leishmania infantum / Q000187:drug effects* / Q000235:genetics; D000075163:Metallocenes; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D001562:Benzimidazoles; D005296:Ferrous Compounds; D007454:Iodides; D000075163:Metallocenes; D014344:Trypanocidal Agents; C004998:ferrocene