title: [Prophylaxis of hepatic veno-occlusive disease by low-molecular-weight heparin and lipo- prostaglandin E1 after allogeneic peripheral blood stem cell transplantation].
abstract: To study the effects of low-molecular-weight heparin and lipid microspheres containing prostaglandin E(1) (lipo PGE) in preventing hepatic veno-occlusive disease after allogeneic peripheral blood stem cell transplantation, we observed 21 cases of allogeneic stem cell transplantation, in which the combined treatments were administered from day -7 to day +30. As a result, only 2 of these cases developed hepatic veno-occlusive disease, without obvious treatment-related adverse effects, suggesting the safety and effectiveness of the combined treatment using low-molecular-weight heparin and lipo PGE1 in the prevention of hepatic veno-occlusive disease after allogenetic stem cell transplantation.
authors.affiliation: Department of Hematology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. xyk00@163.net
authors.forename: Chao-yang
authors.initials: CY
authors.lastname: Song
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Li
authors.forename: Kun-yuan
authors.initials: KY
authors.lastname: Guo
authors.forename: Bing-yi
authors.initials: BY
authors.lastname: Wu
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D006504:Hepatic Veno-Occlusive Disease / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous
chemical_list: D006495:Heparin, Low-Molecular-Weight; D000527:Alprostadil