Ouabain as a mammalian hormone.
Endogenous ouabain changes rapidly in humans and dogs upon physical exercise and is under the control of epinephrine and angiotensin II. Hence, the steroid acts as a rapidly acting hormone. A search for a specific binding globulin for cardiac glycosides in bovine plasma resulted in the identification of the d allotype of the micro chain of IgM whose hydrophobic surfaces interact with cardiotonic steroids and cholesterol. Such IgM complexes might be involved in the hepatic elimination of cardiotonic steroids. Thus, differences in the signaling cascade starting at Na(+),K(+)-ATPase must explain any differences in the action of ouabain and digoxin in the genesis of arterial hypertension.
Schoner
Wilhelm
W
Institute of Biochemistry and Endocrinology, Justus-Liebig-University Giessen, Germany. wilhelm.schoner@vetmed.uni-giessen.de
Bauer
Natali
N
Müller-Ehmsen
Jochen
J
Krämer
Ulrike
U
Hambarchian
Njde
N
Schwinger
Robert
R
Moeller
Hans
H
Kost
Holger
H
Weitkamp
Christine
C
Schweitzer
Thomas
T
Kirch
Ulrike
U
Neu
Horst
H
Grünbaum
Ernst-Güngther
EG
D000328:Adult; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002301:Cardiac Glycosides / Q000378:metabolism*; D002316:Cardiotonic Agents; D002417:Cattle; D002784:Cholesterol / Q000502:physiology; D004285:Dogs; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006728:Hormones / Q000097:blood / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007148:Immunoglobulin mu-Chains / Q000097:blood; D008875:Middle Aged; D010042:Ouabain / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D012016:Reference Values; D013256:Steroids / Q000502:physiology
D002301:Cardiac Glycosides; D002316:Cardiotonic Agents; D006728:Hormones; D007148:Immunoglobulin mu-Chains; D013256:Steroids; D010042:Ouabain; D002784:Cholesterol