title: Enhancement of norepinephrine-induced transient contraction in aortic smooth muscle of diabetic mice.
abstract: Changes in norepinephrine-induced transient contractions in Ca2+-deficient solution were investigated in the aortic smooth muscles of diabetic ALS (alloxan-induced diabetes susceptible) mice. The transient contractions in diabetic mice were significantly larger than those in normal mice. The longer incubation of the muscle preparations in Ca2+-deficient solution made the transient contractions smaller, probably due to the leakage and decrease in norepinephrine-releasable stored Ca2+. The rate of this reduction in contraction was slower in diabetic mice. These results suggest that the leakage of intracellular stored Ca2+ caused by extracellular Ca2+ deficiency is attenuated in diabetic mice, contributing to enhanced norepinephrine-induced transient contractions.
authors.affiliation: Department of Animal Science, Faculty of Agriculture, Okayama University, Okayama 700 8530, Japan. abeasaki@cc.okayama-u.ac.jp
authors.forename: Asaki
authors.initials: A
authors.lastname: Abe
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kawasoe
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kondo
authors.forename: Katsunori
authors.initials: K
authors.lastname: Sato
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology*
chemical_list: D009638:Norepinephrine