Retinal S-antigen-reactive lymphocytes in a patient with uveitis associated with myelodysplastic syndromes.
BACKGROUND
Although autoimmune humoral abnormalities have been reported in patients with myelodysplastic syndromes (MDS), abnormal organ-specific cellular autoimmunity has not been demonstrated.


METHODS
Peripheral blood lymphocytes (PBLs) and serum were collected from a uveitis patient with MDS. Cellular immune response against retinal S-antigen (S-Ag) was assessed by proliferation assay, and humoral immune response to S-Ag was measured by enzyme-linked immunosorbant assay.


RESULTS
PBLs from the patient exhibited vigorous proliferation against S-Ag, while humoral immune response against S-Ag was not detectable. PBLs from controls did not proliferate against S-Ag.


CONCLUSIONS
These results provide new evidence that abnormal cellular immune responses against autoantigens may develop in MDS patients, thus leading to organ-specific autoimmune diseases such as uveitis, in addition to other systemic autoimmune disorders.
Nishino
Koji
K
Department of Ophthalmology, Kochi Medical School, Kochi, Japan.
Fukushima
Atsuki
A
Ueno
Hisayuki
H
D000368:Aged; D000917:Antibody Formation; D019393:Arrestin / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005451:Fluorescein Angiography; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000276:immunology*; D014605:Uveitis / Q000276:immunology*
D019393:Arrestin; D001324:Autoantigens