title: Glutathione metabolism and antioxidant enzymes in children with Down syndrome.
abstract: Oxidative stress has been proposed as a pathogenic mechanism of atherosclerosis, cell aging, and neurologic disorders in Down syndrome. This study demonstrates a systemic decrease of all glutathione forms, including glutathionyl-hemoglobin, in the blood of children with Down syndrome. Furthermore, we obtained a disequilibrium, in vivo, between the antioxidant enzyme activities.
authors.affiliation: Laboratory of Biochemistry, Molecular Medicine Unit, Children's Hospital and Research Institute Bambino Gesù, Rome, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Pastore
authors.forename: Giulia
authors.initials: G
authors.lastname: Tozzi
authors.forename: Laura Maria
authors.initials: LM
authors.lastname: Gaeta
authors.forename: Aldo
authors.initials: A
authors.lastname: Giannotti
authors.forename: Enrico
authors.initials: E
authors.lastname: Bertini
authors.forename: Giorgio
authors.initials: G
authors.lastname: Federici
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Digilio
authors.forename: Fiorella
authors.initials: F
authors.lastname: Piemonte
mesh_terms: D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D004314:Down Syndrome / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D008297:Male; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione