title: The accuracy of transcranial Doppler to detect vasospasm in patients with aneurysmal subarachnoid hemorrhage.
abstract: OBJECTIVE
  To examine the accuracy of transcranial Doppler to detect cerebral vasospasm in a patient population with aneurysmal subarachnoid hemorrhage.
  
  
  METHODS
  Prospective blind comparison of transcranial Doppler with cerebral angiography. Diagnostic accuracy of transcranial Doppler was assessed using receiver operating characteristic (ROC) analysis and likelihood ratios. Sensitivity and specificity were calculated using directly measured middle cerebral artery diameter as reference standard.
  
  
  METHODS
  Intensive Care Unit of a large university teaching hospital.
  
  
  METHODS
  Twenty-two patients with subarachnoid hemorrhage were included. Patients underwent angiography on admission and after 8 days to diagnose vasospasm and were defined as having clinical vasospasm, angiographic vasospasm, or no vasospasm.
  
  
  RESULTS
  Sensitivity and specificity were 1.00 and 0.75 for angiographic vasospasm and both equal to 1.00 for clinical vasospasm diagnosis. A transcranial Doppler mean velocity threshold value of 100 cm/s for angiographic vasospasm and 160 cm/s for clinical vasospasm detection were chosen by ROC analysis.
  
  
  CONCLUSIONS
  A Transcranial Doppler mean velocity threshold of 160 cm/s, calculated by the ROC analysis, accurately detects clinical vasospasm. A daily transcranial Doppler examination performed by a trained operator should be routinely used to provide early identification of patients at high risk and to orient therapeutic decisions.
authors.affiliation: Dipartimento di Discipline Medico-Chirurgiche, Sezione di Anestesiologia e Rianimazione, Ospedale S. Giovanni Battista, Università di Torino, Corso Dogliotti 14, 10126, Torino, Italy. luciana.mascia@unito.it
authors.forename: L
authors.initials: L
authors.lastname: Mascia
authors.forename: L
authors.initials: L
authors.lastname: Fedorko
authors.forename: K
authors.initials: K
authors.lastname: terBrugge
authors.forename: C
authors.initials: C
authors.lastname: Filippini
authors.forename: M
authors.initials: M
authors.lastname: Pizzio
authors.forename: V M
authors.initials: VM
authors.lastname: Ranieri
authors.forename: M C
authors.initials: MC
authors.lastname: Wallace
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario; D012680:Sensitivity and Specificity; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D017585:Ultrasonography, Doppler, Transcranial / Q000592:standards*; D020301:Vasospasm, Intracranial / Q000150:complications / Q000000981:diagnostic imaging*