title: Single nucleotide polymorphism haplotypes in the cholesteryl-ester transfer protein (CETP) gene and lipid phenotypes.
abstract: We studied the association between high (HDL) and low-density (LDL) cholesterol concentrations and family-derived haplotypes based on six common SNPs in the cholesteryl-ester transfer protein (CETP) gene. We based our analysis on 201 founders from families recruited throughout Germany. The analysis revealed one subhaplotype block with complete, pairwise, linkage disequilibrium between 5 SNPs located in the promoter and intron 1. The sixth SNP was the well known 1405V polymorphism in exon 14, close to the 3' end of the gene. Four haplotypes accounted for 86% of the entire sample. We found that haplotype associations with HDL, LDL, and the LDL/HDL ratio were more robust than associations with individual SNPs. Moreover, the associations were robust for men, but not for women. Our data suggest an interaction between gender and genetic variation within the CETP gene.
authors.affiliation: Max Delbrück Center, Medical Faculty of the Charité, Humboldt University of Berlin, Berlin, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Bauerfeind
authors.forename: Hans
authors.initials: H
authors.lastname: Knoblauch
authors.forename: Herbert
authors.initials: H
authors.lastname: Schuster
authors.forename: Friedrich C
authors.initials: FC
authors.lastname: Luft
authors.forename: Jens G
authors.initials: JG
authors.lastname: Reich
mesh_terms: D000328:Adult; D001053:Apolipoproteins / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D053480:Cholesterol Ester Transfer Proteins; D005260:Female; D005858:Germany; D006023:Glycoproteins; D006801:Humans; D008055:Lipids / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood / Q000235:genetics; D008077:Lipoproteins, LDL / Q000097:blood / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009679:Nuclear Family; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012727:Sex Characteristics; D014280:Triglycerides / Q000097:blood
chemical_list: D001053:Apolipoproteins; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides