Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells.
Chronic active Epstein-Barr virus (CAEBV) infection is an uncommon and severe manifestation of EBV infection that frequently leads to the development of natural killer (NK) or T cell lymphomas. We report here that NK cells derived from a boy with CAEBV showed decreased cytotoxic function and impaired interferon-gamma secretion against a variety of transformed target cell lines. In addition, NK cells from the patient lacked expression of the broadly expressed NK receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1). These data suggest that CAEBV is associated with low expression of LAIR-1 on NK cells.
Aoukaty
Ala
A
Department of Pathology & Laboratory Medicine, British Columbia's Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V4.
Lee
I-Fang
IF
Wu
John
J
Tan
Rusung
R
D002478:Cells, Cultured; D002648:Child; D002908:Chronic Disease; D018920:Coculture Techniques; D003602:Cytotoxicity, Immunologic; D020031:Epstein-Barr Virus Infections / Q000276:immunology* / Q000378:metabolism; D005192:Family Health; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism*; D008297:Male; D011971:Receptors, Immunologic / Q000172:deficiency*
D011971:Receptors, Immunologic; C108073:leukocyte-associated immunoglobulin-like receptor 1; D007371:Interferon-gamma