Multilocus sequence typing (MLST) of Escherichia coli O78 strains.
Strains of Escherichia coli serotype O78 are associated with many diseases, including invasive infections, in humans and farm animals. The clonal relationship between strains from different hosts is therefore important for assessing the risk of zoonotic infections. Here we propose a multilocus sequence typing scheme for E. coli, based on six housekeeping genes. Preliminary, but significant, results indicate that clonal division in E. coli O78 strains is host independent, and closely related clones reside in different hosts. There was a positive correlation between virulence and clonal origin.
Adiri
Roni S
RS
Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.
Gophna
Uri
U
Ron
Eliora Z
EZ
D000217:Acyltransferases / Q000235:genetics; D000263:Adenylate Kinase / Q000235:genetics; D000483:Alleles; D000818:Animals; D000829:Animals, Domestic; D002262:Carboxy-Lyases / Q000235:genetics; D004926:Escherichia coli / Q000145:classification* / Q000235:genetics* / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000382:microbiology*; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D051082:Homoserine O-Succinyltransferase; D006801:Humans; D008291:Malate Dehydrogenase / Q000235:genetics; D017856:Phosphotransferases (Phosphate Group Acceptor) / Q000235:genetics; D010802:Phylogeny; D011110:Polymorphism, Genetic; D018805:Sepsis / Q000382:microbiology*; D012703:Serotyping; D014774:Virulence; D015047:Zoonoses
D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D000217:Acyltransferases; D051082:Homoserine O-Succinyltransferase; D017856:Phosphotransferases (Phosphate Group Acceptor); C022424:polyphosphate kinase; D000263:Adenylate Kinase; D002262:Carboxy-Lyases; C022713:tartronate-semialdehyde synthase