Antimicrobial resistance of invasive pneumococci in Finland in 1999-2000.
The resistance patterns and macrolide resistance mechanisms of 910 Finnish invasive pneumococci isolated during 1999 and 2000 were studied. Macrolide resistance was detected in 6.9% of isolates. Penicillin resistance was detected in 1.5% of isolates, and penicillin intermediate resistance was detected in 4.0% of isolates. Active macrolide efflux, mediated by the mef(A) gene, was the most common macrolide resistance mechanism. Four macrolide-resistant isolates had mutations in rRNA or ribosomal protein L22.
Pihlajamäki
Marja
M
Antimicrobial Research Laboratory, National Public Health Institute, Turku, Finland. mapihla@utu.fi
Jalava
Jari
J
Huovinen
Pentti
P
Kotilainen
Pirkko
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple; D005387:Finland; D006801:Humans; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D011008:Pneumococcal Infections / Q000382:microbiology; D016133:Polymerase Chain Reaction; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D018942:Macrolides