title: [Virus infection in children after allogenic stem cell transplantation ].
abstract: Allogenic hematopoietic cell transplantation (alloHCT) is the treatment of choice for various pediatric malignancies and nonmalignant diseases. The most prominent complication of allotransplantation is graft vs host disease (GvHD). The treatment of GvHD influence negatively function of immune system and increase risk of bacterial, fungal and viral infections. Clinical symptoms of viral infection may mimic GvHD and lead to inappropriate treatment. Human cytomegalovirus (CMV, Herpesviridae) has been recognized as most important viral pathogen after alloHCT. Increasing number of procedures, especially from alternative donors, requiring more intensive immunosuppression, led to identification more viral pathogens causing transplant related mortality and morbidity. Among them are adenoviruses (ADV, Adenoviridae), BK and JC viruses (Papovaviridae) and human herpes virus 6 (HHV-6, Herpesviridae). Frequency of complications caused by those pathogens is higher in children then in adults.
authors.affiliation: Laboratorium Wirusologii Instytutu Immunologii i Terapii Doświadczalnej PAN im. L. Hirszfelda we Wrocławiu.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Rybka
authors.forename: Dominik
authors.initials: D
authors.lastname: Turkiewicz
mesh_terms: D000328:Adult; D002648:Child; D003937:Diagnosis, Differential; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D009894:Opportunistic Infections / Q000175:diagnosis / Q000276:immunology; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014777:Virus Diseases / Q000175:diagnosis / Q000276:immunology* / Q000821:virology