title: Increased procollagen alpha1(I) mRNA expression by dermal fibroblasts in melorheostosis.
abstract: We report a patient with melorheostosis in whom increased procollagen alpha1(I) mRNA expression and alpha1(I), alpha2(I) and alpha1(III) collagen secretion were observed in dermal fibroblasts obtained from a skin biopsy overlying the involved bone. The patient was a 53-year-old man with melorheostosis lesions over the left knee joint. Multiple pigmented macules were present on the medial aspect of the lower left leg. Hyperpigmentation of the basal keratinocytes, thick-walled vessels in the reticular dermis, and proliferation of normal-appearing collagen around the hair follicles were observed histologically.
authors.affiliation: Department of Clinical Biology of Extracellular Matrix, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. chw92121@syd.odn.ne.jp
authors.forename: H
authors.initials: H
authors.lastname: Endo
authors.forename: A
authors.initials: A
authors.lastname: Katsumi
authors.forename: K
authors.initials: K
authors.lastname: Kuroda
authors.forename: A
authors.initials: A
authors.lastname: Utani
authors.forename: H
authors.initials: H
authors.lastname: Moriya
authors.forename: H
authors.initials: H
authors.lastname: Shinkai
mesh_terms: D005347:Fibroblasts / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D017495:Hyperpigmentation / Q000378:metabolism* / Q000473:pathology; D007868:Leg Dermatoses / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008557:Melorheostosis / Q000378:metabolism*; D008875:Middle Aged; D011347:Procollagen / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D012867:Skin / Q000378:metabolism* / Q000473:pathology
chemical_list: D011347:Procollagen; D012333:RNA, Messenger