ICM0201, a new inhibitor of osteoclastogenesis from Cunninghamella sp. F-1490. I. Taxonomy, fermentation, isolation and biological activities.
In the course of screening for inhibitors of osteoclastogenesis, a new substance designated as ICM0201 was isolated from a fermentation broth of Cunninghamella sp. F-1490. ICM0201 inhibited the formation of osteoclasts in mouse bone marrow cells with an IC50 value of 0.78 microg/ml and showed weak cytotoxicity against bone marrow cells.
Inoue
Hiroyuki
H
Institute for Chemotherapy, M. C. R. F., 18-24 Miyamoto, Numazu-shi, Shizuoka, 410-0301, Japan.
Kumagai
Hiroyuki
H
Osono
Michiyo
M
Matsufuji
Motoko
M
Sameshima
Tomohiro
T
Kawamura
Naoto
N
Someno
Tetsuya
T
Ishizuka
Masaaki
M
Takeuchi
Tomio
T
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000145:classification* / Q000302:isolation & purification / Q000494:pharmacology; D020093:Cunninghamella / Q000737:chemistry*; D005285:Fermentation; D006575:Heterocyclic Compounds, 3-Ring / Q000145:classification* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010078:Oxazines / Q000145:classification* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D006575:Heterocyclic Compounds, 3-Ring; C474716:ICM 0201; D010078:Oxazines