title: [A study on the percutaneous penetration of artesunate from various reservoir vehicles].
abstract: OBJECTIVE
  To determine the main factors which affect the percutaneous penetration of artesunate and provide efficient data for the artesunate transdermal delivery system.
  
  
  METHODS
  Transdermal speed constant and accumulative amount of 12 hours were used for the estimations of various reservior vehicles, and the supplement orthodox design was used to study the effect of pH, various proportion of IPA/Water/IPM, and drug concentration.
  
  
  RESULTS
  Drug concentration and pH were the main factors which affected the percutaneous penetration of artesunate.
  
  
  CONCLUSIONS
  The suitable reservior vehicle can prompt the percutaneous penetration of artesunate, and artesunate TTS will be made with further studies.
authors.affiliation: Guangzhou University of TCM, Guangzhou 510405, Guangdong, China.
authors.forename: Li-ling
authors.initials: LL
authors.lastname: Zhou
authors.forename: Hai-xia
authors.initials: HX
authors.lastname: Hou
authors.forename: Rui
authors.initials: R
authors.lastname: Li
mesh_terms: D019840:2-Propanol / Q000494:pharmacology*; D000279:Administration, Cutaneous; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000493:pharmacokinetics*; D037621:Artemisinins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000077332:Artesunate; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D004337:Drug Carriers; D012717:Sesquiterpenes; D000077332:Artesunate; D019840:2-Propanol