title: Chlorambucil-induced myoclonus in a cat with lymphoma.
abstract: Chlorambucil is an alkylating agent commonly used in veterinary oncology for conditions including lymphoma. Chlorambucil neurotoxicity has been well recognized in human patients. Onsets of central nervous system signs, such as myoclonus, tremors, muscular twitching, agitation, and tonic-clonic seizures, have been reported in humans and laboratory animals treated with chlorambucil. This case of a cat with intestinal lymphoma represents the first veterinary patient reported to have chlorambucil-induced neurotoxicity. Neurotoxicity should be considered a potential side effect of chlorambucil therapy in veterinary patients.
authors.affiliation: Department of Veterinary Clinical Medicine, Veterinary Teaching Hospital, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, Urbana, Illinois 61802, USA.
authors.forename: Noémi
authors.initials: N
authors.lastname: Benitah
authors.forename: Louis-Philippe
authors.initials: LP
authors.lastname: de Lorimier
authors.forename: Michele
authors.initials: M
authors.lastname: Gaspar
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Kitchell
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D002371:Cat Diseases / Q000175:diagnosis* / Q000473:pathology; D002415:Cats; D002699:Chlorambucil / Q000009:adverse effects*; D003937:Diagnosis, Differential; D007414:Intestinal Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D007421:Intestine, Small; D008223:Lymphoma / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009207:Myoclonus / Q000139:chemically induced / Q000175:diagnosis*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D002699:Chlorambucil