Helicobacter pylori infection induces interleukin-8 receptor expression in the human gastric epithelium.
The gastric pathogen Helicobacter pylori is known to activate multiple proinflammatory signaling pathways in epithelial cells. In this study, we addressed the question of whether expression of the interleukin-8 receptors IL-8RA (CXCR1) and IL-8RB (CXCR2) is upregulated in H. pylori-infected human gastric biopsy samples. Biopsy samples from patients infected with H. pylori strains harboring the cag pathogenicity island (PAI) expressed larger amounts of both receptors. In addition, IL-8RB expression was induced in the gastric epithelial cell line AGS upon infection with a clinical isolate containing the cag PAI, while a strain lacking the cag PAI did not. Our finding suggests that gastric epithelial cells express IL-8R in response to H. pylori infection.
Bäckhed
Fredrik
F
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden. fbackhed@pcg.wustl.edu
Torstensson
Elisabeth
E
Seguin
Delphine
D
Richter-Dahlfors
Agneta
A
Rokbi
Bachra
B
D000293:Adolescent; D000328:Adult; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D008297:Male; D008875:Middle Aged; D023062:Receptors, Interleukin-8A / Q000096:biosynthesis*; D023063:Receptors, Interleukin-8B / Q000096:biosynthesis*; D015854:Up-Regulation; D014774:Virulence / Q000235:genetics
D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B