title: Alternative brain organization after prenatal cerebral injury: convergent fMRI and cognitive data.
abstract: The current study presents both longitudinal behavioral data and functional activation data documenting the effects of early focal brain injury on the development of spatial analytic processing in two children, one with prenatal left hemisphere (LH) injury and one with right hemisphere (RH) injury. A substantial body of evidence has shown that adults and children with early, lateralized brain injury show evidence of spatial analytic deficits. LH injury compromises the ability to encode the parts of a spatial pattern, while RH injury impairs pattern integration. The two children described in this report show patterns of deficit consistent with the site of their injury. In the current study, their longitudinal behavioral data spanning the age range from preschool to adolescence are presented in conjunction with data from a functional magnetic resonance imaging (fMRI) study of spatial processing. The activation results provide evidence that alternative profiles of neural organization can arise following early focal brain injury, and document where in the brain spatial functions are carried out when regions that normally mediate them are damaged. In addition, the coupling of the activation with the behavioral data allows us to go beyond the simple mapping of functional sites, to ask questions about how those sites may have come to mediate the spatial functions.
authors.affiliation: Department of Cognitive Science, University of California, San Diego 92093-0515, USA. stiles@ucsd.edu
authors.forename: Joan
authors.initials: J
authors.lastname: Stiles
authors.forename: Pamela
authors.initials: P
authors.lastname: Moses
authors.forename: Katherine
authors.initials: K
authors.lastname: Roe
authors.forename: Natacha A
authors.initials: NA
authors.lastname: Akshoomoff
authors.forename: Doris
authors.initials: D
authors.lastname: Trauner
authors.forename: John
authors.initials: J
authors.lastname: Hesselink
authors.forename: Eric C
authors.initials: EC
authors.lastname: Wong
authors.forename: Lawrence R
authors.initials: LR
authors.lastname: Frank
authors.forename: Richard B
authors.initials: RB
authors.lastname: Buxton
mesh_terms: D000293:Adolescent; D002544:Cerebral Infarction / Q000150:complications* / Q000473:pathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005315:Fetal Diseases; D005500:Follow-Up Studies; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010291:Paresis / Q000209:etiology; D010296:Parietal Lobe / Q000098:blood supply / Q000473:pathology*; D010468:Perceptual Disorders / Q000175:diagnosis / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications; D012720:Severity of Illness Index; D013028:Space Perception / Q000502:physiology