title: A new antifouling hexapeptide from a Palauan sponge, Haliclona sp.
abstract: Bioassay-guided fractionation of an extract of the sponge Haliclona sp. provided a known hexapeptide, waiakeamide (1), and a new sulfone derivative (2). The structures of hexapeptides 1 and 2 were elucidated by extensive NMR analyses and the advanced Marfey's method with LC/MS. These compounds showed repellent activity against the blue mussel, Mytilus edulis galloprovincialis.
authors.affiliation: Marine Biotechnology Institute, 75-1 Heita, Kamaishi 026-0001, Japan. sera_y@hitachizosen.co.jp
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sera
authors.forename: Kyoko
authors.initials: K
authors.lastname: Adachi
authors.forename: Kiyonaga
authors.initials: K
authors.lastname: Fujii
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Shizuri
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D049872:Bivalvia / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D019029:Palau; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C478191:waiakeamide