Hyperferritinemia revealing Gaucher's disease.
Hyperferritinemia is frequently observed during Gaucher's disease but has never been described as an initial manifestation. We report the case of a 57-year-old woman without a previous medical history who presented with hyperferritinemia and IgG monoclonal gammopathy. The diagnostic procedure was negative except for the bone marrow biopsy, which revealed Gaucher's cells. Low beta-glucocerebrosidase activity in leukocytes confirmed the diagnosis of adult Gaucher's disease. We discuss the differential diagnosis and the mechanisms of hyperferritinemia in this disease.
Decaux
O
O
Département de Médecine de l'Adulte, Hôpital Sud, 16 boulevard de Bulgarie, 35056 Cedex., Rennes, France
Cazalets
C
C
Grandgirard
N
N
Fergelot
P
P
Jego
P
P
Grosbois
B
B