title: Repair of segmental long bone defect in rabbit femur using bioactive titanium cylindrical mesh cage.
abstract: A segmental rabbit femur defect was repaired using an empty bioactive titanium (BAT) mesh cage. A 10mm long titanium mesh cage was positioned in the bony defect and reinforced by intramedullary fixation. The BAT surface was prepared by chemical and thermal treatment. Pure titanium cages were used as a control. Torsional stiffness of the BAT group at 4 weeks was approximately equal to, and at 8 weeks twice, that of the intact femur. Differences between the torsional stiffness of the control and BAT groups were significant at both time intervals. Histological examinations showed that woven bone appeared around the cage by 4 weeks and transformed to lamella bone by 8 weeks. New bone bonded to the BAT surface without an intervening layer. The BAT cage enhanced the bone repairing process and achieved faster repair of long bone segmental defects.
authors.affiliation: Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kawahara-Cho 54, Sakyo-Ku, Kyoto 606-8507, Japan. shfuji@kuhp.kyoto-u.ac.jp
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Fujibayashi
authors.forename: Hyun-Min
authors.initials: HM
authors.lastname: Kim
authors.forename: Masashi
authors.initials: M
authors.lastname: Neo
authors.forename: Masaki
authors.initials: M
authors.lastname: Uchida
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kokubo
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D001031:Apatites; D001672:Biocompatible Materials; D005269:Femur / Q000166:cytology / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D005594:Fracture Fixation, Intramedullary / Q000379:methods*; D020007:Implants, Experimental; D008422:Materials Testing; D016348:Osseointegration; D011817:Rabbits; D011859:Radiography; D013499:Surface Properties; D013696:Temperature; D013718:Tensile Strength; D014025:Titanium
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D014025:Titanium