Do human and JC virus genes show evidence of host-parasite codemography?
Information about similarities and differences in the demographic history of host and parasite populations is potentially useful for making inferences about a variety of evolutionary processes. However, it is difficult to observe the historical demographic properties of natural populations directly. Here, the extent of demographic similarity in a host and its parasite was examined indirectly by inferring long-term population history from patterns of genetic variation. Nucleotide sequence diversity in human and JC virus (JCV) DNA is consistent with a long-term demographic connection between the two species: both show evidence of large-scale population expansion. However, genetic data also suggest that the two species have different patterns of population substructuring. These similarities and differences have implications for adaptive evolution in JCV that are not evident when the two species are considered separately.
Wooding
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Department of Anthropology, University of Utah, 270 South 1400 East, Salt Lake City, UT 84112-0060, USA. stephen.wooding@anthro.utah.edu
D000349:Africa / Q000453:epidemiology; D000595:Amino Acid Sequence; D001208:Asia / Q000453:epidemiology; D005060:Europe / Q000453:epidemiology; D019143:Evolution, Molecular; D014644:Genetic Variation / Q000235:genetics; D006790:Host-Parasite Interactions; D006801:Humans; D007577:JC Virus / Q000235:genetics*; D008969:Molecular Sequence Data; D027601:Polyomavirus Infections / Q000453:epidemiology / Q000235:genetics*; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000235:genetics*