Molecular regulation of urokinase-receptor gene expression as one potential concept for molecular staging and therapy.
The urokinase-receptor (u-PAR) is a central molecule of invasion and metastasis promoting plasminogen-dependent extracellular matrix degradation in diverse carcinoma types such as gastric or colon cancer. Overexpression of u-PAR has been reported to occur mainly at the transcriptional level in malignant cells, and has been shown to indicate a poor clinical prognosis of cancer patients. This review will give an overview on experimental findings on u-PAR and its function, molecular mechanisms of its regulation, and its impact for future clinical decision planning and potential therapeutic concepts.
Allgayer
Heike
H
Department of Surgery, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Marchioninistr. 15, 81377 Munich, Germany.
D014408:Biomarkers, Tumor; D005109:Extracellular Matrix / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D010641:Phenotype; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology*; D055293:Receptors, Urokinase Plasminogen Activator; D015398:Signal Transduction; D014158:Transcription, Genetic; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
D014408:Biomarkers, Tumor; C524898:PLAUR protein, human; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator