Diabetic ketoacidosis and its treatment increase plasma 3-deoxyglucosone.
OBJECTIVE
Highly reactive dicarbonyl compounds are known to be increased by hyperglycemia, ketone bodies and lipid peroxidation. This study was carried out to investigate the effect of diabetic ketoacidosis (DKA) and its treatment on the plasma concentration of 3 deoxyglucosone (3-DG) one of the dicarbonyl compounds.


METHODS
3-DG was measured in 7 children before, during and following correction of severe DKA. 3-DG was elevated before treatment (610 nmol/L +or/- 70) in comparison to baseline (120 h) (200 nmol/L+/or- 17) (p < 0.05). At 6 to 24 h into treatment 3-DG was further elevated (1080 nmol/L +or/- 80) in comparison to both pretreatment (p < 0.05) and baseline (p < 0.05).


CONCLUSIONS
3-DG is significantly elevated before the treatment of DKA and increases further during the treatment of DKA. The time course of the increase of 3-DG coincides with the time of progression of subclinical brain edema, which occurs in DKA.
Hoffman
William H
WH
Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA. whoffman@mail.mcg.edu
Kappler
Frank
F
Passmore
Gregory G
GG
Mehta
Renuka
R
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D016883:Diabetic Ketoacidosis / Q000097:blood* / Q000150:complications / Q000628:therapy; D004573:Electrolytes / Q000097:blood; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013997:Time Factors
D001786:Blood Glucose; D004573:Electrolytes; D003847:Deoxyglucose; C016350:3-deoxyglucosone