title: Type I sensitization in adolescents: prevalence and association with atopic dermatitis. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS).
abstract: The prevalence of Type I sensitization and its relationship to atopic dermatitis were assessed in a cohort of 1501 8th grade schoolchildren (aged 12-16) in Odense, Denmark. The protocol included a questionnaire, a clinical examination, IgE measurements and skin prick tests. A history of atopic dermatitis was found in 21.3%, allergic asthma in 6.9% and allergic rhinitis in 15.7% of the adolescents. One or more positive specific IgE measurements (CAP FEIA) were found in 29.6% of the schoolchildren (inhalant allergens 28.4%, food allergens 8.5%, pityrosporum ovale 1.5%) and a considerable proportion were sensitized without clinical relevance. The association between atopic dermatitis and Type I sensitization was related to concomitant inhalant allergy. A clear association with atopic dermatitis was indicated only for the allergen pityrosporum ovale.
authors.affiliation: Department of Dermatology, Odense University Hospital, Odense, Denmark. mortz@imbmed.ou.dk
authors.forename: Charlotte Gotthard
authors.initials: CG
authors.lastname: Mortz
authors.forename: Jens Martin
authors.initials: JM
authors.lastname: Lauritsen
authors.forename: Klaus Ejner
authors.initials: KE
authors.lastname: Andersen
authors.forename: Carsten
authors.initials: C
authors.lastname: Bindslev-Jensen
mesh_terms: D000293:Adolescent; D002648:Child; D003877:Dermatitis, Contact / Q000150:complications*; D006801:Humans; D006967:Hypersensitivity / Q000150:complications*; D007073:Immunoglobulin E / Q000276:immunology
chemical_list: D007073:Immunoglobulin E