Oocyte and embryo quality in patients with excessive ovarian response during in vitro fertilization treatment.
OBJECTIVE
This study examined oocyte and embryo quality in patients having excessive ovarian responses during assisted reproduction treatment.


METHODS
Two hundred and seventy-eight women of age <40 years using a long protocol of pituitary downregulation in their first intracytoplasmic sperm injection cycle indicated for severe male factors were retrospectively evaluated. Those with serum estradiol concentration on the day of HCG <10,000, 10,000-20,000, and >20,000 pmol/L were classified into Group A, Group B, and Group C, respectively.


RESULTS
The percentage of metaphase II oocytes (85%), fertilization rate (60-66%), and distribution of blastomere number per embryo were similar among the three groups. The proportion of transferable embryos was not reduced in Group C when compared to those of Groups A and B.


CONCLUSIONS
Excessive ovarian response does not compromise oocyte and embryo quality in humans. Freezing of all embryos is recommended in these patients in view of associated impaired endometrial receptivity.
Ng
Ernest Hung Yu
EH
Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China. nghye@hkucc.hku.hk
Lau
Estella Yee Lan
EY
Yeung
William Shu Biu
WS
Ho
Pak Chung
PC
D000328:Adult; D001757:Blastomeres / Q000502:physiology; D004624:Embryo Transfer; D004622:Embryo, Mammalian / Q000502:physiology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D008677:Metaphase; D009865:Oocytes / Q000166:cytology*; D010053:Ovary / Q000502:physiology*; D011247:Pregnancy; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods
D004958:Estradiol