Sequence and embryonic expression of collagen XVIII NC1 domain (endostatin) in the zebrafish.
Endostatin, located in the NC1 domain of the collagen XVIII, is believed to inhibit the migration and proliferation of endothelial cells (Fed. Am. Soc. Exp. Biol. J. 15 (2001) 1044) and to play a role in axon guidance in Caenorhabditis elegans (J. Cell Biol. 152 (2001) 1219). Zebrafish is an attractive vertebrate model to determine the role of endostatin and the entire molecule of collagen XVIII during vertebrate development. Therefore, we have investigated the expression pattern of COL18A1 in zebrafish embryos from the segmentation to the hatching period stages.
Haftek
Zofia
Z
Institut de Biologie et Chimie des Protéines, CNRS, UMR 5086, 7 passage du Vercors, 69367 Lyon Cedex 07, France.
Morvan-Dubois
Ghislaine
G
Thisse
Bernard
B
Thisse
Christine
C
Garrone
Robert
R
Le Guellec
Dominique
D
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D043169:Endostatins / Q000096:biosynthesis / Q000235:genetics*; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D015027:Zebrafish / Q000196:embryology* / Q000378:metabolism
D043169:Endostatins