title: Experience with predeposition of autologous blood in elective orthopaedic and plastic surgery: the role of oral iron medication.
abstract: The risk of transmission of transfusion-associated infections, mainly AIDS, led to the increased use of autologous transfusion by four methods: predeposition of autologous blood, haemodilution, intraoperative and postoperative blood salvage. We started a program of autologous predeposition at blood transfusion centre of Saint Andrews General Hospital of Patras in co-operation with orthopaedic and plastic surgery in 1992. To date, 617 autologous units have been collected from 257 patients undergoing various operations. Our protocol was as follows: the minimum Hb value before each donation was 12 g/dl, body weight over 50 kg, age 18-70 years and 8-10 day intervals between donations. The exclusion criteria were anaemia, evidence of blood loss, renal disease, chronic and acute inflammatory or malignant disorders, pregnancy and lactation. We chose 40 patients with haemoglobin values of 13-15 g/dl and ferritin levels > 50 ng/ml, who gave three autologous units. They were separated in two groups of twenty patients. Those in group 1 received 300 mg of elemental iron in three daily oral doses, while the others in group 2 received no iron medication. We studied haematologic variables, reticulocytes and ferritin levels in both groups before each autologous donation. We also studied the possible complications and their incidence in patients over 60 years old. According to our results, haematologic variables such as Hb, mean corpuscular Hb (MCH), mean corpuscular volume (MCV) and reticulocytes were not influenced by oral iron therapy. We observed a slight increase in MCV in both study groups which means the production of larger red blood cells. We also noticed a higher decrease of ferritin in patients with no iron therapy, but without a fall of ferritin levels under the normal values. We conclude that oral iron therapy in non-iron deficient patients undergoing a moderate program of three autologous units is not necessary. In addition, autologous blood donation is also feasible in patients over 60 years old without severe complications.
authors.affiliation: Blood Transfusion Centre, Saint Andrews General Hospital of Patras, 43 Kefallinas Street, Patras 264 41, Greece. dimap@med.upatras.gr
authors.forename: P
authors.initials: P
authors.lastname: Tseliou
authors.forename: D J
authors.initials: DJ
authors.lastname: Apostolopoulos
authors.forename: G
authors.initials: G
authors.lastname: Chronopoulos
authors.forename: A
authors.initials: A
authors.lastname: Antonopoulos
authors.forename: P
authors.initials: P
authors.lastname: Korovesis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001782:Blood Donors; D001804:Blood Transfusion, Autologous; D017558:Elective Surgical Procedures; D005260:Female; D006115:Greece; D006801:Humans; D007501:Iron / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures; D011300:Preoperative Care; D019651:Plastic Surgery Procedures
chemical_list: D007501:Iron