title: Pentoxifylline inhibits leukocyte infiltration and splenocyte cytotoxicity against murine colon adenocarcinoma.
abstract: Pentoxifylline (PTX), a methylxanthine derivative, is commonly used in patients suffering from peripheral vascular diseases. Besides its well-known hemorheological properties PTX has been found to decrease the secretion of some inflammatory cytokines such as TNF, IL-12 and IFN-gamma. PTX also suppresses lymphocyte cytotoxicity, affecting mainly the perforin-dependent pathway. We investigated the influence of PTX on the splenocyte cytotoxicity and leukocyte infiltration in a murine colon adenocarcinoma model. We observed that PTX decreased the cytotoxic activity of isolated splenocytes against C-26 cells and reduced the inflammatory cell infiltration in the peritumoral tissue. Thus, our results strongly suggest the necessity of further studies concerning the safety of PTX use, especially in elderly patients or patients with already diagnosed cancer.
authors.affiliation: Department of Histology and Embryology, Center of Biostructure Research, The Medical University of Warsaw, 5 Chalubinskiego Street, PL 02 004 Warsaw, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Lazarczyk
authors.forename: Tomasz
authors.initials: T
authors.lastname: Grzela
authors.forename: Justyna
authors.initials: J
authors.lastname: Niderla
authors.forename: Jakub
authors.initials: J
authors.lastname: Golab
authors.forename: Grazyna
authors.initials: G
authors.lastname: Korczak-Kowalska
authors.forename: Monika
authors.initials: M
authors.lastname: Oldak
authors.forename: Piotr
authors.initials: P
authors.lastname: Skopinski
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms / Q000276:immunology / Q000473:pathology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D005260:Female; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D016246:Lymphocytes, Tumor-Infiltrating / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010431:Pentoxifylline / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology; D014407:Tumor Cells, Cultured
chemical_list: D010726:Phosphodiesterase Inhibitors; D010431:Pentoxifylline