title: There is no evidence for the existence of complex formation between doxorubicin and glutathione.
abstract: Doxorubicin is co-transported with glutathione by several multidrug resistance proteins (MRPs). In order to check whether weak non-covalent aggregates between doxorubicin and glutathione can be formed, which might be substrates for the transporter, the effect of glutathione on the partition coefficient of doxorubicin was studied. No evidence of an effect of glutathione (at levels up to 20 microM) on the partition coefficient of doxorubicin was found in the pH range of 4.0-7.4. These results indicate that non-covalent doxorubicin-glutathione complexes do not form.
authors.affiliation: Department of Molecular Biophysics, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Marszałek
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Bartosz
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Bartosz
mesh_terms: D000255:Adenosine Triphosphate; D004317:Doxorubicin / Q000378:metabolism*; D005453:Fluorescence; D005978:Glutathione / Q000378:metabolism*
chemical_list: D004317:Doxorubicin; D000255:Adenosine Triphosphate; D005978:Glutathione