title: Synthesis and antiviral activity of a series of new cyclohexenyl nucleosides.
abstract: A series of new cyclohexenyl nucleosides is synthesized by coupling the heterocyclic bases with a protected cyclohexenyl precursor under Mitsunobu conditions. The compounds were evaluated for their antiviral and cytostatic activity. Pronounced activity against herpes simplex virus type 1 and type 2 was observed for the 2,6-diaminopurine analogue.
authors.affiliation: Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Ping
authors.initials: P
authors.lastname: Gu
authors.forename: Jordi
authors.initials: J
authors.lastname: Morral
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Jef
authors.initials: J
authors.lastname: Rozenski
authors.forename: Roger
authors.initials: R
authors.lastname: Busson
authors.forename: Arthur
authors.initials: A
authors.lastname: Van Aerschot
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Piet
authors.initials: P
authors.lastname: Herdewijn
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003510:Cyclohexanes / Q000737:chemistry; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D003510:Cyclohexanes; D009705:Nucleosides