cPSA and fPSA elimination in African-American men.
In all, 22 African-American males undergoing radical prostatectomy for prostate adenocarcinoma had serum drawn for tPSA, cPSA, and total protein concentrations prior to, during, and after operation to determine the respective elimination rates. African-American cPSA was found to fit best a simple first-order exponential elimination kinetic, with a half-life of 44.6 h. fPSA followed a two-compartment elimination with an alpha-phase elimination of 0.50 h and a beta-phase half-life of 4.2 h. Our results suggest higher rates of elimination for both cPSA and fPSA in an African-American male population with respect to Caucasians and may account for differences in PSA values between races.
Martin
B J
BJ
Department of Urology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
Cheli
C
C
Davis
R
R
Ward
M
M
Kokatnur
M
M
Mercante
D
D
Lifsey
D
D
Rayford
W
W
D000230:Adenocarcinoma / Q000208:ethnology* / Q000473:pathology*; D000328:Adult; D001741:Black or African American; D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood* / Q000493:pharmacokinetics*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000208:ethnology* / Q000473:pathology*; D012016:Reference Values; D044465:White People
D017430:Prostate-Specific Antigen