title: Migraine aura dynamics after reverse retinotopic mapping of weak excitation waves in the primary visual cortex.
abstract: Akinematical model for excitable wave propagation is analyzed to describe the dynamics of a typical neurological symptom of migraine. The kinematical model equation is solved analytically for a linear dependency between front curvature and velocity. The resulting wave starts from an initial excitation and moves in the medium that represents the primary visual cortex. Due to very weak excitability the wave propagates only across a confined area and eventually disappears. This cortical excitation pattern is projected onto a visual hemifield by reverse retinotopic mapping. Weak excitability explains the confined appearance of aura symptoms in time and sensory space. The affected area in the visual field matches in growth and form the one reported by migraine sufferers. The results can be extended from visual to tactile and to other sensory symptoms. If the spatiotemporal pattern from our model can be matched in future investigations with those from introspectives, it would allow one to draw conclusions on topographic mapping of sensory input in human cortex.
authors.forename: M A
authors.initials: MA
authors.lastname: Dahlem
authors.forename: S C
authors.initials: SC
authors.lastname: Müller
mesh_terms: D001931:Brain Mapping; D020325:Migraine with Aura / Q000503:physiopathology; D008954:Models, Biological; D010775:Photic Stimulation / Q000379:methods; D012160:Retina / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology