title: Synthesis and metal-binding properties of chelating fluorescein derivatives.
abstract: [reaction: see text] Two routes to highly functionalized metal-chelating fluorescein derivatives have been pursued. Compound 3 is partially quenched by a variety of first-row transition metal ions in aqueous solution, with EC(50) values ranging from 0.4 to 60 microM. Compounds of this type may find application in biological sensing.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Clark
authors.forename: Kathryn
authors.initials: K
authors.lastname: Duffy
authors.forename: Jyoti
authors.initials: J
authors.lastname: Tibrewala
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Lippard
mesh_terms: D002614:Chelating Agents / Q000737:chemistry*; D005452:Fluoresceins / Q000737:chemistry*; D008024:Ligands; D019216:Metals, Heavy / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D002614:Chelating Agents; D005452:Fluoresceins; D008024:Ligands; D019216:Metals, Heavy