title: Impact of iron loading on the activity of isoniazid or ethambutol in the treatment of murine tuberculosis.
abstract: OBJECTIVE
  To assess the impact of iron loading on the activity of isoniazid and ethambutol in the treatment of murine tuberculosis.
  
  
  METHODS
  Iron-loaded and iron-normal female Balb/C mice infected with 1.5 x 10(7) colony forming units of Mycobacterium tuberculosis were treated with either isoniazid or ethambutol for 28 days.
  
  
  RESULTS
  For both treatments, the outcome was impaired by the iron loading: bactericidal activity of isoniazid was partially but significantly reduced and ethambutol bactericidal activity was totally inhibited.
  
  
  CONCLUSIONS
  The treatment of tuberculosis in patients with iron loading should be longer than for normal patients or should contain an additional drug.
authors.affiliation: Laboratoire de Bactériologie, Faculté de Médecine Pitié-Salpêtrière, Paris, France. nacerlounis@yahoo.fr
authors.forename: N
authors.initials: N
authors.lastname: Lounis
authors.forename: C
authors.initials: C
authors.lastname: Maslo
authors.forename: C
authors.initials: C
authors.lastname: Truffot-Pernot
authors.forename: J
authors.initials: J
authors.lastname: Grosset
authors.forename: R J
authors.initials: RJ
authors.lastname: Boelaert
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004347:Drug Interactions; D004977:Ethambutol / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D007501:Iron / Q000494:pharmacology*; D007538:Isoniazid / Q000494:pharmacology* / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D014376:Tuberculosis / Q000188:drug therapy* / Q000401:mortality
chemical_list: D000995:Antitubercular Agents; D004977:Ethambutol; D007501:Iron; D007538:Isoniazid