title: Insular carcinoma of the thyroid.
abstract: Thyroid surgeons are becoming increasingly more aware of a histologically distinct subset of thyroid carcinoma whose classification falls between well-differentiated and anaplastic carcinomas with respect to both cell differentiation and clinical behavior. This subtype of tumors has been categorized as poorly differentiated or insular carcinoma, based on its characteristic cell groupings. Although the differentiation of insular carcinoma from other thyroid carcinomas has important prognostic and therapeutic significance, relatively little about insular carcinoma has been published in the otolaryngology literature. In this article, we describe a new case of insular carcinoma and we discuss the findings of our review of the literature. We conclude that insular thyroid carcinoma warrants aggressive management with total thyroidectomy followed by radioactive iodine ablation of any remaining thyroid tissue.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Jefferson Medical College, Philadelphia, USA.
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Cornetta
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Burchard
authors.forename: Edmund A
authors.initials: EA
authors.lastname: Pribitkin
authors.forename: Robert C
authors.initials: RC
authors.lastname: O'Reilly
authors.forename: Juan P
authors.initials: JP
authors.lastname: Palazzo
authors.forename: William M
authors.initials: WM
authors.lastname: Keane
mesh_terms: D001707:Biopsy, Needle; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D018570:Risk Assessment; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods; D016896:Treatment Outcome