Stress-limiting effect of dehydroepiandrosterone sulfate and its mechanism.
Dehydroepiandrosterone sulfate prevented the increase in corticosterone level in rats induced by repeated exposure to stress. The mu-opioid receptor blocker naltrexone administered in a dose of 0.1 mg/kg 20 min before treatment with dehydroepiandrosterone sulfate abolished the effect of this agent. Dehydroepiandrosterone sulfate and naltrexone had no effect on rats after acute stress.
Obut
T A
TA
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. T.A.Obut@iph.ma.nsc.ru
Ovsyukova
M V
MV
Cherkasova
O P
OP
D000818:Animals; D003345:Corticosterone / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D009271:Naltrexone / Q000008:administration & dosage / Q000378:metabolism; D009292:Narcotic Antagonists / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological
D009292:Narcotic Antagonists; D019314:Dehydroepiandrosterone Sulfate; D009271:Naltrexone; D003345:Corticosterone