title: The roles of activin in cytoprotection and tissue repair.
abstract: Activin is a member of the transforming growth factor beta family of growth and differentiation factors. Initially discovered as a protein that stimulates release of follicle-stimulating hormone, it is now well accepted as an important regulator of cell growth and differentiation. Most interestingly, a series of previous studies have revealed novel roles of activin in inflammation and repair. Our own results have provided evidence for an important function of activin in cutaneous wound repair as well as in neuroprotection, and these data will be summarized and discussed in this chapter.
authors.affiliation: Institute of Cell Biology, ETH Zürich, Hönggerberg, CH-8093 Zürich, Switzerland.
authors.forename: Miriam
authors.initials: M
authors.lastname: Wankell
authors.forename: Silke
authors.initials: S
authors.lastname: Werner
authors.forename: Christian
authors.initials: C
authors.lastname: Alzheimer
authors.forename: Sabine
authors.initials: S
authors.lastname: Werner
mesh_terms: D028341:Activins / Q000502:physiology*; D000818:Animals; D019610:Cytoprotection; D038681:Follistatin / Q000502:physiology; D007249:Inflammation / Q000209:etiology; D015603:Keratinocytes / Q000378:metabolism; D051379:Mice; D009024:Morphogenesis; D009414:Nerve Growth Factors / Q000502:physiology; D012867:Skin / Q000033:anatomy & histology / Q000196:embryology; D012879:Skin Physiological Phenomena; D014945:Wound Healing
chemical_list: D038681:Follistatin; D009414:Nerve Growth Factors; D028341:Activins