Synthesis of a novel cis-proline-derived cyclic type VI beta-turn mimic via ring-closing metathesis.
A cis-proline derived cyclic mimic of a type VI beta-turn is synthesized via a ring-closing metathesis reaction. The solution NMR conformational study indicates that the major conformer of the cyclic peptide adopts a type VIa beta-turn in CDCl(3) and a type VIb beta-turn in DMSO-d(6).
Boruah
Anima
A
Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India.
Rao
I Nageshwar
IN
Nandy
Jyoti Prokash
JP
Kumar
S Kiran
SK
Kunwar
A C
AC
Iqbal
Javed
J
D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D011392:Proline / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013237:Stereoisomerism
D010456:Peptides, Cyclic; D011392:Proline