[Biochemical and sonographic values in early pregnancy in women with a history of early spontaneous abortion].
BACKGROUND
The aim of this study was to examine interconnections between changes in serum levels of biochemical parameters during pregnancy and sonographic parameters relevant for evaluation of early pregnancy.


METHODS
We analyzed serum levels of human chorionic gonadotropin (hCG), estradiol (E2), progesterone (PRG) and prolactin (PRL) using ELISA method, in cases of complicated pregnancies with symptoms of imminent miscarriage, and in patients with uncomplicated pregnancies. We evaluated their impact on mean gestational sac diameter (MSD), crown-rump length (CRL), inner diameter of the vitelline sac (SV), trophoblast (Trf) thickness and embryonic heart rate (STP). All results were correlated using Pearson's test and regression.


RESULTS
Changes in biochemical parameters of pregnancy correlate significantly with dimensions of analyzed sonographic parameters.


CONCLUSIONS
Levels of chorionic gonadrotropin affect production of ovarian and placental steroidogenesis. Interrelations were also discussed.


CONCLUSIONS
Changes in biochemical values of pregnancy hormones affect dimensions of analyzed sonographic parameters. During uncomplicated pregnancy, levels of chorionic gonadotropin, progesterone and estradiol affect mean gestation-sac diameter, embryo length, depth of trophoblast invasion and formation and function of vitelline sac, and thus they alter the embryonic heart rate.
Mitreski
Anita
A
Klinika za ginekologiju i akuserstvo, Klinicki centar, Novi Sad. anitamitreski@hotmail.com
Radeka
Gordana
G
D000026:Abortion, Habitual / Q000097:blood / Q000175:diagnosis*; D000033:Abortion, Threatened / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D011247:Pregnancy; D016216:Ultrasonography, Prenatal
D015415:Biomarkers; D006728:Hormones