title: Microbial metabolites of harman alkaloids.
abstract: Several microorganisms showed the ability to transform the harman alkaloids, harmaline (1), harmalol (2) and harman (5). Harmaline (1) and harmalol (2) were converted by Rhodotorula rubra ATCC 20129 into the tryptamines, 2-acetyl-3-(2-acetamidoethyl)-7-methoxyindole (3) and 2-acetyl-3-(2-acetamidoethyl)-7-hydroxyindole (4), respectively. Harman (5) was biotransformed by Cunninghamella echinulata NRRL 3655 into 6-hydroxyharman (6) and harman-2-oxide (7).
authors.affiliation: National Center of Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, MS 38677, USA.
authors.forename: Wimal
authors.initials: W
authors.lastname: Herath
authors.forename: Julie Rakel
authors.initials: JR
authors.lastname: Mikell
authors.forename: Daneel
authors.initials: D
authors.lastname: Ferreira
authors.forename: Ikhlas Ahmad
authors.initials: IA
authors.lastname: Khan
mesh_terms: D001711:Biotransformation; D020093:Cunninghamella / Q000378:metabolism*; D006246:Harmaline / Q000031:analogs & derivatives* / Q000378:metabolism; D006247:Harmine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012248:Rhodotorula / Q000378:metabolism*
chemical_list: C007904:harmalol; D006247:Harmine; C005010:harman; D006246:Harmaline