title: [A serial study of in cytogenetic change and morphology on the tetra-arsenic tetra-sulfide treatment in untreated or recurrent acute promyelocytic leukemia].
abstract: OBJECTIVE
  To study the morphologic and cytogenetic change in acute promyelocytic leukemia (APL) patients during the tetra-arsenic tetra-sulfide (TATS) treatment and the mechanism of TATS.
  
  
  METHODS
  The bone marrow cells of 13 newly diagnosed and 7 recurrent APL patients were studied through FISH and morphology during the TATS treatment by special and repeated marrow culture.
  
  
  RESULTS
  Cytomorphological study of 8 cases (6 untreated and 2 recurrent) showed that TATS could differentiate APL cells forward to mature granulocytes. There was obvious correlation between the reduced t (15; 17) positive cells and the reduced APL cells (r range 0.7298 - 0.9989). Except one patient with t (11; 17), 19 (13 untreated and 7 recurrent) with translocation t (15; 17) achieved clinical CR including 16 who achieved cytogenetic CR.
  
  
  CONCLUSIONS
  TATS has a differentiation-inducing effect on untreated and recurrent APL, with haematological CR and cytogenetic CR achieved. Measurement of t (15; 17) positive cells by FISH technique can reflect the change of APL cells objectively.
authors.affiliation: Cytogenetic Laboratory, Instituste of Hematology, People's Hospital, Beijing University, Beijing 100044, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Jing-ying
authors.initials: JY
authors.lastname: Qiu
authors.forename: Dao-pei
authors.initials: DP
authors.lastname: Lu
authors.forename: Bo
authors.initials: B
authors.lastname: Hong
authors.forename: Hui-lin
authors.initials: HL
authors.lastname: Shi
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Hui
authors.initials: H
authors.lastname: Dang
authors.forename: Qi
authors.initials: Q
authors.lastname: He
mesh_terms: D000328:Adult; D001152:Arsenicals / Q000627:therapeutic use*; D001853:Bone Marrow / Q000473:pathology; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013440:Sulfides / Q000627:therapeutic use*; D014178:Translocation, Genetic
chemical_list: D001152:Arsenicals; D013440:Sulfides; C534735:tetraarsenic tetrasulfide