title: ST-segment monitoring in patients with acute coronary syndromes.
abstract: ST-segment analyses from electrocardiograms during acute coronary syndromes (ACS) have repeatedly shown strong mechanistic links to coronary artery patency and myocardial reperfusion. In these patients, such analyses have also consistently been reported to have close correlations with outcome--correlations superior even to those reported for invasive coronary flow measurements and outcome. Continuous multilead ST-monitoring of patients with ACS provides accurate and noninvasive information on the dynamics of the myocardial reperfusion process over time. This information can be used for improved early diagnostic accuracy, evaluation of treatment efficacy, early risk-stratification, and can be supportive in clinical decision making regarding these patients. Continuous multilead ST-monitoring during ACS is no longer a cumbersome source of more nuisance than benefit, but can be an accurate and useful tool in multicenter clinical trials, as well as in clinical medicine.
authors.affiliation: Duke University Medical Center, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27705, USA. johan003@mc.duke.edu
authors.forename: Per
authors.initials: P
authors.lastname: Johanson
authors.forename: Galen S
authors.initials: GS
authors.lastname: Wagner
authors.forename: Mikael
authors.initials: M
authors.lastname: Dellborg
authors.forename: Mitchell W
authors.initials: MW
authors.lastname: Krucoff
mesh_terms: D000208:Acute Disease; D000789:Angina, Unstable / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D004562:Electrocardiography; D006801:Humans; D008991:Monitoring, Physiologic; D009203:Myocardial Infarction / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D013577:Syndrome