Spontaneous death of bone marrow and peripheral blood cells during remission of acute lymphoblastic leukemia in children.
Programmed antileukemic chemotherapy is associated with prolonged cytotoxic effects on not only tumor cells, but on intact bone marrow and peripheral blood cells as well. The maximum spontaneous cell death is observed immediately after the end of therapy. It decreases with time after therapy, but does not reach the level observed in healthy subjects and does not depend on the type of therapy. The percentage of dead cells in peripheral blood directly correlates with the percentage of dead cells in the bone marrow. The processes of cell death in the peripheral blood and bone marrow are synchronous and parallel.
Kaznacheev
K S
KS
Laboratory of Molecular Cellular and Immunomorphological Bases of Oncohematology, State Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. pathol@cyber.ma.nsc.ru
Vladimirskaya
E B
EB
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D017209:Apoptosis / Q000187:drug effects; D001773:Blood Cells / Q000187:drug effects / Q000473:pathology*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000473:pathology*; D002648:Child; D006098:Granulocytes / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000188:drug therapy / Q000473:pathology*