title: Bone health in patients with fibromyalgia.
abstract: OBJECTIVE
  To determine whether women with fibromyalgia are at increased risk of developing osteoporosis or osteomalacia.
  
  
  METHODS
  Forty premenopausal women with fibromyalgia and 37 age-matched female controls were studied. Broadband ultrasound attenuation (BUA) and velocity of sound (VOS) were measured at the calcaneum and bone mineral density was measured at the forearm and lumbar spine using dual-energy X-ray absorptiometry. Serum calcium, alkaline phosphatase, gamma-glutamyl transferase, 25-hydroxyvitamin D and plasma viscosity were measured in all subjects and parathyroid hormone was measured in subjects recruited in the latter part of the study.
  
  
  RESULTS
  Seventeen patients with fibromyalgia syndrome and seven controls had 25-hydroxyvitamin D concentrations <20 nmol/l (P < 0.015) and in three FMS patients serum parathyroid hormone was raised. Bone density in fibromyalgia patients was slightly lower at the mid-distal forearm but comparable to that in controls at other sites.
  
  
  CONCLUSIONS
  There is no reason to recommend routine bone densitometry in fibromyalgia patients. However, vitamin D subnutrition is common in these patients and this should be sought.
authors.affiliation: University Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK.
authors.forename: A W
authors.initials: AW
authors.lastname: Al-Allaf
authors.forename: P A
authors.initials: PA
authors.lastname: Mole
authors.forename: C R
authors.initials: CR
authors.lastname: Paterson
authors.forename: T
authors.initials: T
authors.lastname: Pullar
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015519:Bone Density; D016022:Case-Control Studies; D005260:Female; D005356:Fibromyalgia / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D010018:Osteomalacia / Q000209:etiology; D010024:Osteoporosis / Q000209:etiology*; D017697:Premenopause / Q000097:blood / Q000502:physiology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D