title: Oncogenic human papillomavirus DNA loads in human immunodeficiency virus-positive women with high-grade cervical lesions are strongly elevated.
abstract: Human papillomavirus (HPV) DNA loads of six oncogenic HPV types were measured by real-time PCR in cervical scrapes of human immunodeficiency virus (HIV)-infected and uninfected women. In both groups, HPV loads increased with the grade of cervical disease. HIV infection did not affect HPV loads in low-grade lesions but was associated with significantly higher HPV loads in severe dysplasia; highest loads were found in advanced HIV disease. Our data reflect the aggressive course of HPV infection in HIV-positive women.
authors.affiliation: Institute of Virology, University of Cologne, 50935 Cologne, Germany. soenke.weissenborn@medizin.uni-koeln.de
authors.forename: S J
authors.initials: SJ
authors.lastname: Weissenborn
authors.forename: A M
authors.initials: AM
authors.lastname: Funke
authors.forename: M
authors.initials: M
authors.lastname: Hellmich
authors.forename: P
authors.initials: P
authors.lastname: Mallmann
authors.forename: P G
authors.initials: PG
authors.lastname: Fuchs
authors.forename: H J
authors.initials: HJ
authors.lastname: Pfister
authors.forename: U
authors.initials: U
authors.lastname: Wieland
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000032:analysis*; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000821:virology*; D016133:Polymerase Chain Reaction; D002577:Uterine Cervical Diseases / Q000503:physiopathology / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000503:physiopathology / Q000821:virology*
chemical_list: D004279:DNA, Viral