Visual loss in uveitis of childhood.
OBJECTIVE
To investigate the manifestations and severity of uveitis in children and to identify the risk and specific causes of blindness in this population.


METHODS
Retrospective study of data of 123 consecutive patients examined with active uveitis and the onset of ocular disease before the age of 16 years. Numerous variables were assessed including age and sex distribution, laboratory data, the presence of systemic diseases, onset and course of ocular inflammation, clinical features and complications, therapeutic strategies and their outcomes, final visual acuity, and characteristics associated with poor visual outcome.


RESULTS
Systemic disease was observed in 36/123 patients (29%), with juvenile idiopathic arthritis being the most frequent (25/123, 20%). Toxoplasma retinochoroiditis was diagnosed in 12/23 patients with posterior uveitis (52%; 10% of all with uveitis). Severe intraocular inflammation required systemic drugs in 57 (46%) patients. Ocular complications were observed in 93 patients (76%), of which the most common was cataract (43/123, 35%). Intraocular surgery was required in 35 patients (28%; in total 75 procedures). Three patients (2%) became legally blind and an additional 20/121 (17%) had one legally blind eye caused by uveitis. The most frequent causes of blindness were chorioretinal scars in the macular area and glaucoma in contrast with cystoid macular oedema (CMO) in adults.


CONCLUSIONS
Uveitis in childhood is a potentially blinding disease, in the majority of patients characterised by a chronic course and a high complication rate.
de Boer
J
J
FC Donders Institute of Ophthalmology, University Medical Center, Utrecht, Netherlands. j.deboer-3@oogh.azu.nl
Wulffraat
N
N
Rothova
A
A
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000150:complications; D001766:Blindness / Q000209:etiology* / Q000503:physiopathology; D002386:Cataract / Q000150:complications; D002648:Child; D002675:Child, Preschool; D002833:Choroiditis / Q000150:complications; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D012173:Retinitis / Q000150:complications; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014123:Toxoplasmosis / Q000150:complications; D014605:Uveitis / Q000150:complications* / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology