title: Superoxide dismutase mimetics. Part 2: synthesis and structure-activity relationship of glyoxylate- and glyoxamide-derived metalloporphyrins.
abstract: Novel glyoxylate- and glyoxamide-derived metalloporphyrins 26-58 were synthesized and evaluated as potential superoxide dismutase (SOD) mimetics. Relative to previously studied MnTBAP analogues, the glyoxylate-derived metalloporphyrins 32, 39, and 54 and glyoxamide-derived metalloporphyrin 49, exhibited enhanced activity in the SOD assay and the majority of the analogues in the current series showed enhanced inhibition of lipid peroxidation and catalase activity.
authors.affiliation: Albany Molecular Research, Inc., 21 Corporate Circle, PO Box 15098, Albany, NY 12212-5098, USA.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Trova
authors.forename: Polivina Jolicia F
authors.initials: PJ
authors.lastname: Gauuan
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Pechulis
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Bubb
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Bocckino
authors.forename: James D
authors.initials: JD
authors.lastname: Crapo
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Day
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D002374:Catalase / Q000037:antagonists & inhibitors; D006038:Glyoxylates / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects; D008665:Metalloporphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018716:Molecular Mimicry; D013329:Structure-Activity Relationship; D013453:Sulfonylurea Compounds / Q000737:chemistry; D013482:Superoxide Dismutase / Q000737:chemistry* / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D006038:Glyoxylates; D008665:Metalloporphyrins; D013453:Sulfonylurea Compounds; D017392:Thiobarbituric Acid Reactive Substances; C032160:glyoxamide; D002374:Catalase; D013482:Superoxide Dismutase