title: The role of neural inflammation in asthma and chronic obstructive pulmonary disease.
abstract: The tachykinins substance P and neurokinin A are found within airway nerves and immune cells. They have various effects on the airways that can contribute to the changes observed in asthma and chronic obstructive pulmonary disease. Both tachykinin NK(1) and NK(2) receptors have been involved in the bronchoconstriction and the proinflammatory changes induced by substance P and neurokinin A. Tachykinin NK(1) and NK(2) receptor antagonists have activity in various animal models of allergic asthma and chronic bronchitis. It is suggested that dual NK(1)/NK(2) and triple NK(1)/NK(2)/NK(3) tachykinin receptor antagonists have potential in the treatment of obstructive airway diseases.
authors.affiliation: Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Ghent, Belgium. guy.joos@rug.ac.be
authors.forename: Guy F
authors.initials: GF
authors.lastname: Joos
authors.forename: Katelijne O
authors.initials: KO
authors.lastname: De Swert
authors.forename: Vanessa
authors.initials: V
authors.lastname: Schelfhout
authors.forename: Romain A
authors.initials: RA
authors.lastname: Pauwels
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology*; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D020932:Nerve Growth Factor / Q000502:physiology; D009420:Nervous System / Q000276:immunology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000276:immunology*; D018040:Receptors, Neurokinin-1 / Q000276:immunology; D018041:Receptors, Neurokinin-2 / Q000276:immunology; D015320:Tachykinins / Q000037:antagonists & inhibitors / Q000276:immunology
chemical_list: D018040:Receptors, Neurokinin-1; D018041:Receptors, Neurokinin-2; D015320:Tachykinins; D020932:Nerve Growth Factor