Experimental autoimmune encephalomyelitis relapses are reduced in heterozygous golli MBP knockout mice.
Increased golli MBP (golli) expression has been observed in the peripheral immune system of mice in the relapsing phase of EAE, raising the possibility that golli MBP expression in the periphery may contribute to relapses. Here we describe the generation of golli MBP-deficient mice and a comparison of the clinical course of EAE between heterozygous (golli(+/-)) and wild-type (golli(+/+)) mice. There was no difference between the two groups in incidence of disease, severity of the first episode of disease, or remission after the first episode. However, there was a significant reduction in relapses in golli(+/-) mice vs. controls, suggesting a role for golli proteins in the relapses in EAE.
Voskuhl
Rhonda R
RR
Reed Neurological Research Center, UCLA Department of Neurology, 710 Westwood Plaza, Los Angeles, CA 90095, USA. rvoskuhl@ucla.edu
Pribyl
Thomas M
TM
Kampf
Kathy
K
Handley
Vance
V
Liu
Hong-biao
HB
Feng
JiMing
J
Campagnoni
Celia W
CW
Soldan
Samantha S
SS
Messing
Albee
A
Campagnoni
Anthony T
AT
D000818:Animals; D002490:Central Nervous System / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D018450:Disease Progression; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology; D006579:Heterozygote; D007111:Immunity, Cellular / Q000235:genetics; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D004676:Myelin Basic Protein / Q000172:deficiency* / Q000235:genetics; D009186:Myelin Sheath / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000172:deficiency* / Q000235:genetics; D012008:Recurrence; D014157:Transcription Factors / Q000172:deficiency* / Q000235:genetics
C499047:Mbp protein, mouse; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins; D014157:Transcription Factors