Immune responsiveness, tolerance and dsRNA: implications for traditional paradigms.
Double-stranded (ds)RNA motifs are central to immune regulation and block tolerance to tumor-associated, self- and foreign antigens. In addition, they could explain why DNA vectors encoding self-replicating mRNA (replicons) are more immunogenic than conventional DNA vaccines. Accumulating evidence on the immunomodulatory roles of dsRNAs warrants a reconsideration of various models of immune homeostasis.
von Herrath
Matthias G
MG
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.
Bot
Adrian
A
D000818:Animals; D006801:Humans; D007107:Immune System / Q000502:physiology; D007108:Immune Tolerance; D008562:Membrane Glycoproteins / Q000378:metabolism; D012330:RNA, Double-Stranded / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D012093:Replicon / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors
D008562:Membrane Glycoproteins; D012330:RNA, Double-Stranded; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors