The role of lymphotoxin in development and maintenance of secondary lymphoid tissues.
Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen-specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs.
Tumanov
Alexei V
AV
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow 119991, Russia. tumanov@imb.ac.ru
Kuprash
Dmitry V
DV
Nedospasov
Sergei A
SA
D000818:Animals; D008221:Lymphoid Tissue / Q000166:cytology / Q000254:growth & development* / Q000276:immunology; D008233:Lymphotoxin-alpha / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000172:deficiency / Q000235:genetics / Q000502:physiology
D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha