title: Prolonged aspirin inhibition of anodal vasodilation is not due to the trafficking delay of neural mediators.
abstract: We previously reported that forearm vasodilation to a delivered all-at-once over 5 min or a 1-min repeated monopolar anodal 0.10-mA current application is aspirin sensitive and that a single high-dose aspirin exerts a long-lived effect in the former case. We hypothesized that 1) in the latter case, the effect of aspirin would also be long lived and 2) the time required to resupply nerve endings with unblocked cyclooxygenase through axonal transport could explain this phenomenon. We studied the time course for the recovery of vasodilation to repeated current application after placebo or 1-g aspirin treatment. We then searched for a difference at a proximal vs. distal site in the recovery of the response. Aspirin abolished current-induced vasodilation at 2 h, 10 h, and 3 days, with a progressive recovery thereafter, but no difference between distal and proximal site was observed for the recovery of the response. This suggests that, although neural cyclooxygenase could participate in the response, the time course of aspirin inhibition of current-induced cutaneous vasodilation is not due to the time required through neural transport to resupply nerve endings with unblocked proteins.
authors.affiliation: Laboratoire de Physiologie et Explorations Vasculaires, Centre Hospitalier Universitaire, 49033 Angers cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Durand
authors.forename: B
authors.initials: B
authors.lastname: Fromy
authors.forename: M
authors.initials: M
authors.lastname: Tartas
authors.forename: A
authors.initials: A
authors.lastname: Jardel
authors.forename: J L
authors.initials: JL
authors.lastname: Saumet
authors.forename: P
authors.initials: P
authors.lastname: Abraham
mesh_terms: D000328:Adult; D001241:Aspirin / Q000008:administration & dosage*; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage*; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D012867:Skin / Q000098:blood supply / Q000294:innervation; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D016861:Cyclooxygenase Inhibitors; D018377:Neurotransmitter Agents; D001241:Aspirin