Oncogenic human papillomavirus DNA loads in human immunodeficiency virus-positive women with high-grade cervical lesions are strongly elevated.
Human papillomavirus (HPV) DNA loads of six oncogenic HPV types were measured by real-time PCR in cervical scrapes of human immunodeficiency virus (HIV)-infected and uninfected women. In both groups, HPV loads increased with the grade of cervical disease. HIV infection did not affect HPV loads in low-grade lesions but was associated with significantly higher HPV loads in severe dysplasia; highest loads were found in advanced HIV disease. Our data reflect the aggressive course of HPV infection in HIV-positive women.
Weissenborn
S J
SJ
Institute of Virology, University of Cologne, 50935 Cologne, Germany. soenke.weissenborn@medizin.uni-koeln.de
Funke
A M
AM
Hellmich
M
M
Mallmann
P
P
Fuchs
P G
PG
Pfister
H J
HJ
Wieland
U
U
D000293:Adolescent; D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000032:analysis*; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000821:virology*; D016133:Polymerase Chain Reaction; D002577:Uterine Cervical Diseases / Q000503:physiopathology / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000503:physiopathology / Q000821:virology*
D004279:DNA, Viral