Self-renewal and differentiation of hematopoietic stem cells: a molecular approach (a review).
Two characteristics define a hematopoietic stem cell: the ability to differentiate into all hematopoietic lineages, and the ability to maintain hematopoiesis over a life span by a self-renewal process. The mechanisms that regulate the fate of blood-forming cells in vivo, however, are poorly understood. Despite the ability to culture hematopoietic progenitor cells (committed to particular lineages), in vitro culture of self-renewing multipotent stem cells has not yet been achieved. What is clear that both intrinsic and extrinsic signals regulate hematopoietic stem cell fate and some of these signals have now been identified. which will be highlighted in this review.
Uher
F
F
National Medical Center, Diószegi út 64, Budapest, Hungary.
Hajdu
Melinda
M
Vas
Virág
V
D000818:Animals; D060565:Argonaute Proteins; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005786:Gene Expression Regulation; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D008565:Membrane Proteins / Q000494:pharmacology*; D051379:Mice; D051059:PTEN Phosphohydrolase; D010744:Phosphoric Monoester Hydrolases / Q000494:pharmacology*; D011506:Proteins / Q000494:pharmacology*; D051880:Receptors, Notch; D025521:Tumor Suppressor Proteins / Q000494:pharmacology*
D060565:Argonaute Proteins; D008565:Membrane Proteins; C421088:PIWIL1 protein, human; D011506:Proteins; D051880:Receptors, Notch; D025521:Tumor Suppressor Proteins; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human