The pleiotropic functions of the Y-box-binding protein, YB-1.
The Y-box-binding protein (YB-1) represents the most evolutionary conserved nucleic-acid-binding protein currently known. YB-1 is a member of the cold-shock domain (CSD) protein superfamily. It performs a wide variety of cellular functions, including transcriptional regulation, translational regulation, DNA repair, drug resistance and stress responses to extracellular signals. As a result, YB-1 expression is closely associated with cell proliferation. In this review, we will begin by briefly describing the characteristics of YB-1 and will then summarize the pleiotropic functions brought about via DNA-RNA transaction and protein-protein interactions. In addition, we will discuss the diverse range of potential physiological and pathological functions of YB-1.
Kohno
Kimitoshi
K
Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.
Izumi
Hiroto
H
Uchiumi
Takeshi
T
Ashizuka
Megumi
M
Kuwano
Michihiko
M
D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004260:DNA Repair; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D051839:NFI Transcription Factors; D009687:Nuclear Proteins; D014176:Protein Biosynthesis; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D014714:Vertebrates; D051840:Y-Box-Binding Protein 1
D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; D051839:NFI Transcription Factors; D009687:Nuclear Proteins; D014157:Transcription Factors; D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human