title: [Effect of sappan wood on perforin mRNA expression in myocardium of rats after allogeneic cardiac transplantation].
abstract: OBJECTIVE
  To observe the effect of Sappan wood (SW) on the expression of perforin mRNA in myocardium of rats after allogeneic cardiac transplantation.
  
  
  METHODS
  The animal model of allogeneic (abdominal) cardiac transplantation was established by taking Wistar rat as provider and SD rat as receptor, perforin mRNA expression in the model's myocardium was detected by RT-PCR.
  
  
  RESULTS
  SW could obviously reduce the perforin mRNA expression, it also could alleviate the pathological morphology and ultrastructural damage of myocardial cells.
  
  
  CONCLUSIONS
  SW has obvious effect in antagonizing immune rejection after transplantation, the mechanism of its immunosuppression could be through lowering the perforin mRNA expression.
authors.affiliation: First Affiliated Hospital, Heilongjiang TCM University, Harbin 150040. zhouyabin@hotmail.com
authors.forename: Ya-bin
authors.initials: YB
authors.lastname: Zhou
authors.forename: Feng-zhen
authors.initials: FZ
authors.lastname: Yao
authors.forename: Jia-rui
authors.initials: JR
authors.lastname: Han
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D016027:Heart Transplantation; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000235:genetics; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D014184:Transplantation, Homologous
chemical_list: D004365:Drugs, Chinese Herbal; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D012333:RNA, Messenger; D054353:Perforin