Deficiency of protein S-mediated familial venous thrombophilia--a case report.
Deficiency of protein S causes potential problems of thrombosis. Cases of familial venous thrombosis due to deficiency of protein S were presented. First, an 85-year-old woman had pulmonary thromboembolism due to left deep femoral venous thrombosis, which might be triggered by leg fracture and the long-term treatment with a plaster cast. Next, her 29-year-old granddaughter had episodes of recurrent venous thrombosis in her legs and arms, which might be triggered by the treatment with a plaster cast and abortion. In the latter part, the aspects of risks for thromboembolism, potential problems in gestational period, and an advisability of thromboprophylaxis in patients with deficiency of protein S are described.
Harada
Tomohiro
T
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. tomoharada-circ@umin.ac.jp
Morita
Hiroyuki
H
Imai
Yasushi
Y
Hayashi
Doubun
D
Takeda
Norihiko
N
Maemura
Koji
K
Yazaki
Yoshio
Y
Nagai
Ryozo
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D006801:Humans; D018455:Protein S Deficiency / Q000150:complications* / Q000235:genetics; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D012307:Risk Factors; D019851:Thrombophilia / Q000209:etiology* / Q000235:genetics / Q000628:therapy
D000925:Anticoagulants