title: Human enamel dissolution in citric acid as a function of pH in the range 2.30< or =pH< or =6.30--a nanoindentation study.
abstract: The objective of this study was to investigate the dissolution of human enamel in citric acid solutions over a wide range of pH. The in vitro conditions are considered to be relevant to soft drink-induced enamel erosion. Nanoindentation was used to investigate changes in the nanomechanical properties of polished enamel surfaces after exposure to citric acid solutions. Solutions used had 38.1 mmol l-1 citric acid and pH greater than 2.3 but less than 6.3 (2.30 < or = pH < or = 6.30). Samples were exposed to rapidly stirred, constant composition solutions for 120 s. Statistically significant changes in enamel hardness and reduced elastic modulus were observed after exposure to all solutions. There was an approximately linear dependence of enamel hardness on solution pH for 2.90 < or = pH < or = 6.30. Below pH 2.90, enamel is thought to have reached the lowest possible hardness value. The reduction in enamel dissolution caused by an increase in pH of a soft drink is likely to be small. Product modification to reduce the erosive potential of drinks may require additional methods such as addition of calcium salts.
authors.affiliation: Department of Oral and Dental Science, Biomedical Engineering and Biomaterials Science Section, University of Bristol, Bristol, UK.
authors.forename: Michele E
authors.initials: ME
authors.lastname: Barbour
authors.forename: David M
authors.initials: DM
authors.lastname: Parker
authors.forename: Geoff C
authors.initials: GC
authors.lastname: Allen
authors.forename: Klaus D
authors.initials: KD
authors.lastname: Jandt
mesh_terms: D019343:Citric Acid / Q000494:pharmacology*; D003743:Dental Enamel / Q000187:drug effects*; D003747:Dental Enamel Solubility / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004548:Elasticity; D006244:Hardness; D006245:Hardness Tests; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008963:Molar; D014077:Tooth Erosion / Q000139:chemically induced
chemical_list: D019343:Citric Acid