Extra amino group-containing gramicidin S analogs possessing outer membrane-permeabilizing activity.
Novel (2S,4R)- and (2S,4S)-4-aminoproline residue-containing analogs of the cyclic decapeptide antibiotic gramicidin S were synthesized, which exhibited marked permeabilizing activity on the outer membrane of gram-negative bacteria.
Kawai
Masao
M
Department of Applied Chemistry, Nagoya Institute of Technology, Nagoya 466-8555, Japan. kawai@ach.nitech.ac.jp
Tanaka
Ryoji
R
Yamamura
Hatsuo
H
Yasuda
Keiko
K
Narita
Shizuto
S
Umemoto
Hiroshi
H
Ando
Setsuko
S
Katsu
Takashi
T
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006096:Gramicidin / Q000031:analogs & derivatives* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular
D000900:Anti-Bacterial Agents; D006096:Gramicidin