title: Lack of hemispheric dominance for consciousness in acute ischaemic stroke.
abstract: BACKGROUND
  Previous reports have suggested left hemispheric dominance for maintaining consciousness, although there is controversy over this claim.
  
  
  OBJECTIVE
  To compare early impairment of level of consciousness between patients with right and left hemispheric stroke.
  
  
  METHODS
  Data from 564 patients with ischaemic stroke enrolled in the placebo arm of a trial of a putative neuroprotectant were analysed. All patients had major hemispheric stroke with cortical dysfunction, visual field deficit, and limb weakness, with symptom onset within 12 hours of enrolment. Patients were prospectively evaluated on a predefined scale (1-6; 1 = fully awake, higher scores representing greater impairment) to measure level of consciousness at multiple time points over the initial 24 hours after presentation. The National Institutes of Health (NIH) stroke scale score at presentation and infarct volume at 30 days were determined.
  
  
  RESULTS
  Some degree of impairment in level of consciousness was observed in 409 of the 564 patients (73%). Median maximum sedation score was 2 for both right and left hemispheric stroke (p = 0.91). Mean sedation score over 24 hours was 1.5 for both right and left stroke (p = 0.75). There was no difference between level of consciousness scores in right and left stroke at any individual time point during the 24 hour monitoring period. No association between side and impairment in level of consciousness was seen after adjustment for stroke severity and infarct volume.
  
  
  CONCLUSIONS
  In contrast to previous reports, there was no evidence for hemispheric dominance for consciousness in the setting of a major hemispheric stroke.
authors.affiliation: Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA. cucchiar@mail.med.upenn.edu
authors.forename: B
authors.initials: B
authors.lastname: Cucchiara
authors.forename: S E
authors.initials: SE
authors.lastname: Kasner
authors.forename: D A
authors.initials: DA
authors.lastname: Wolk
authors.forename: P D
authors.initials: PD
authors.lastname: Lyden
authors.forename: V A
authors.initials: VA
authors.lastname: Knappertz
authors.forename: T
authors.initials: T
authors.lastname: Ashwood
authors.forename: T
authors.initials: T
authors.lastname: Odergren
authors.forename: A
authors.initials: A
authors.lastname: Nordlund
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications* / Q000523:psychology*; D015331:Cohort Studies; D003243:Consciousness; D004292:Dominance, Cerebral; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology; D011446:Prospective Studies; D020521:Stroke / Q000150:complications* / Q000523:psychology*