The SLAM family of immune-cell receptors.
The 'signalling lymphocyte activation molecule' (SLAM) family is a newly appreciated group of immune-cell specific receptors that has the ability to regulate the function of several immune cell types. Recent studies show that the SLAM-related receptors mediate intracellular protein tyrosine phosphorylation signals. This property is dependent on the aptitude of SLAM-family receptors to bind with high affinity to SAP and/or EAT-2, two small adaptor molecules composed almost exclusively of a Src homology 2 domain. SAP is mutated in X-linked lymphoproliferative disease, a human immune dysfunction characterised by an inappropriate response to Epstein-Barr virus infection, thereby suggesting that the SLAM-related receptors may be critical for a normal immune response. The existence of the SLAM family broadens the spectrum of receptors known to be involved in immunomodulation.
Veillette
André
A
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montréal, Québec, Canada. veillea@ircm.qc.ca
Latour
Sylvain
S
D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism; D000818:Animals; D015703:Antigens, CD; D002352:Carrier Proteins / Q000378:metabolism; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D007136:Immunoglobulins / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic / Q000502:physiology*; D000071179:Signaling Lymphocytic Activation Molecule Associated Protein; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D014157:Transcription Factors / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport; D015703:Antigens, CD; D002352:Carrier Proteins; D006023:Glycoproteins; D007136:Immunoglobulins; D047908:Intracellular Signaling Peptides and Proteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; C114953:SH2D1A protein, human; C103572:SH2D1B protein, human; C499569:Sh2d1a protein, mouse; C491225:Sh2d1b1 protein, mouse; D000071179:Signaling Lymphocytic Activation Molecule Associated Protein; D014157:Transcription Factors; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1