title: Connectivity optimization and the positioning of cortical areas.
abstract: By examining many alternative arrangements of cortical areas, we have found that the arrangement actually present in the brain minimizes the volume of the axons required for interconnecting the areas. Our observations support the notion that the organization of cortical areas has evolved to optimize interareal connections.
authors.affiliation: Howard Hughes Medical Institute and Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Vitaly A
authors.initials: VA
authors.lastname: Klyachko
authors.forename: Charles F
authors.initials: CF
authors.lastname: Stevens
mesh_terms: D001369:Axons; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D006801:Humans; D015233:Models, Statistical; D016011:Normal Distribution; D017397:Prefrontal Cortex / Q000033:anatomy & histology* / Q000502:physiology