Pathologic characteristics of prostatic adenocarcinomas: a mapping analysis of Korean patients.
Pathologic characteristics of the prostatic adenocarcinoma in Koreans are not clear. We studied 132 cases of prostatectomy specimens using mapping analysis to discover the pathologic characteristics of the Korean prostatic adenocarcinoma. Mean values were as follows: serum prostate-specific antigen level (sPSA), 16.4 ng/ml; tumor volume, 27.5%; size, 2.4 cm; Gleason score, 7.7; and p53 expression, 9.8%. Rates of multifocal tumors and high-grade prostatic intraepithelial neoplasm (HPIN) were 33.3 and 65.2%. The Gleason score, tumor volume%, tumor size and sPSA were correlated with each other. Korean prostatic adenocarcinomas showed higher Gleason scores, lower rates of HPIN and multifocality, and lower p53 expression in comparison to Western prostatic adenocarcinomas. These data may be a basis for pathologic characteristics of Korean prostatic adenocarcinoma that has now been increasing.
Song
S Y
SY
Department of Pathology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea. yodasong@smc.samsung.co.kr
Kim
S R
SR
Ahn
G
G
Choi
H Y
HY
D000230:Adenocarcinoma / Q000208:ethnology / Q000235:genetics / Q000473:pathology*; D000368:Aged; D006801:Humans; D007150:Immunohistochemistry; D007723:Korea; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000032:analysis* / Q000235:genetics; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000235:genetics / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D016159:Tumor Suppressor Protein p53; D017430:Prostate-Specific Antigen