Extracardiac anomalies, aneuploidy and growth retardation in 100 consecutive fetal congenital heart defects.
The importance of extracardiac anomalies in 100 consecutive fetuses with congenital heart disease was evaluated. The most common cardiac diagnoses were hypoplastic left heart syndrome in 35% and atrioventricular canal defect in 15%. Extracardiac anomalies were present in 42%, abnormal karyotype in 19% and intrauterine growth retardation in 20%. There were 45 survivors (35 required neonatal surgery, ten did not require early surgery) and 80% (36/45) of the survivors had isolated congenital heart disease. Extracardiac anomalies and abnormal karyotype were more frequently present in non-survivors (p < 0.001). Also, intrauterine growth retardation was more frequent in non-survivors (p < 0.05).
Respondek
M L
ML
Pennsylvania Hospital, Philadelphia 19107, USA.
Binotto
C N
CN
Smith
S
S
Donnenfeld
A
A
Weil
S R
SR
Huhta
J C
JC