Agmatine reduces hydrogen peroxide in mesangial cells under high glucose conditions.
Agmatine, an amine and organic cation, reduced H(2)O(2) that was generated by hyperglycemia, and transcription factors such as NF-kappaB and AP-1 activity in the mesangial cells that were exposed to high glucose. However, spermine which shares a strong nucleophilic structure with agmatine decreased the H(2)O(2) levels and AP-1, but not the NF-kappaB activity. Possible roles for agmatine and spermine in decreasing fibronectin are discussed, and the signaling pathway for agmatine-reduced fibronectin accumulation is presented.
Lee
Geun Taek
GT
Department of Biochemistry, College of Science, Yonsei University, Seoul 120-749, Korea.
Ha
Hunjoo
H
Lee
Hyun Chul
HC
Cho
Young Dong
YD
D000376:Agmatine / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005353:Fibronectins / Q000378:metabolism; D005920:Glomerular Mesangium / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000378:metabolism*; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D011073:Polyamines / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D013096:Spermine / Q000494:pharmacology; D018808:Transcription Factor AP-1 / Q000378:metabolism
D005353:Fibronectins; D016328:NF-kappa B; D011073:Polyamines; D017382:Reactive Oxygen Species; D018808:Transcription Factor AP-1; D013096:Spermine; D000376:Agmatine; D006861:Hydrogen Peroxide; D005947:Glucose