Nonconvulsive status epilepticus due to a de novo contralateral focus during tiagabine adjunctive therapy.
We describe a 30-year-old woman with an infantile-onset epilepsy due to a left temporal gliotic area who developed a nonconvulsive status epilepticus (NCSE) during tiagabine (TGB) adjunctive therapy. The ictal EEG recording showed a de novo right temporal focus not previously evident. After the i.v. administration of 4 mg lorazepam, the NCSE episode rapidly resolved and her usual left temporal EEG abnormalities reappeared. To our knowledge this is the first case of paradoxical seizure exacerbation associated with TGB therapy in which the clinical and EEG features are congruous with a new contralateral focus.
Imperiale
Daniele
D
Neurologic Unit-Maria Vittoria Hospital, Torino, Italy. imperid@inwind.it
Pignatta
Piero
P
Cerrato
Paolo
P
Montalenti
Elisa
E
Ravetti
Carlo
C
Benna
Paolo
P
D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D004292:Dominance, Cerebral / Q000187:drug effects*; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D017029:Epilepsy, Complex Partial / Q000188:drug therapy*; D005260:Female; D005911:Gliosis / Q000150:complications; D006801:Humans; D009557:Nipecotic Acids / Q000008:administration & dosage / Q000009:adverse effects*; D010296:Parietal Lobe / Q000187:drug effects; D013226:Status Epilepticus / Q000139:chemically induced* / Q000175:diagnosis; D013702:Temporal Lobe / Q000187:drug effects; D000078308:Tiagabine
D000927:Anticonvulsants; D009557:Nipecotic Acids; D000078308:Tiagabine