Role of leukotrienes in stress-induced damage to the heart.
Experiments on rabbits with epinephrine-induced damage to the heart showed that progression of necrotic degenerative processes in the myocardium is augmented by increased content of prostaglandin F(2alpha)and predominance of constrictive over vasodilatory effects in the E and F(2alpha)prostaglandin system. Twenty-four hours after injection of epinephrine we observed an increase in blood concentrations of myofibrillar fraction of creatine phosphokinase, serotonin and histamine, and the F(2alpha)/E prostaglandin ratio. The concentration of leukotriene B(4)increased during the urgent adaptation period, which correlated with a decrease in elastic properties of erythrocytes. In vitro passage of erythrocytes through a 2.5-micro capillary sieve sharply decreased, which played an important role in the progression of myocardial and cerebral hypoxia and ischemia. Myocardial necrosis and endothelial dysfunction developed 24 h later aggravate these pathological shifts.
Gongadze
N V
NV
Department of Pharmacology, Tbilisi State Medical University.
Kezeli
T D
TD
D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D004837:Epinephrine / Q000378:metabolism / Q000633:toxicity; D006335:Heart Injuries / Q000209:etiology / Q000503:physiopathology*; D007527:Isoenzymes / Q000097:blood; D015289:Leukotrienes / Q000097:blood / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism; D011453:Prostaglandins / Q000097:blood / Q000378:metabolism; D011817:Rabbits; D013312:Stress, Physiological / Q000503:physiopathology*
D007527:Isoenzymes; D015289:Leukotrienes; D011453:Prostaglandins; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form; D009638:Norepinephrine; D004837:Epinephrine