title: Synthesis and characterization of novel dipeptide ester prodrugs of acyclovir.
abstract: Four dipeptide (Gly-Gly, Gly-Val, Val-Val, Val-Gly) ester prodrugs of 9-[(2-hydroxyethoxy)methyl]guanine (acyclovir, ACV) were synthesized. LC/MS was used to characterize the new prodrugs. Both 1H NMR and 13C NMR spectra of the four prodrugs of ACV were measured and assigned based on spectral comparison with compounds of similar structures.
authors.affiliation: Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 5005 Rockhill Road, Kansas City, MO 64110-2499, USA.
authors.forename: Yasser E
authors.initials: YE
authors.lastname: Nashed
authors.forename: Ashim K
authors.initials: AK
authors.lastname: Mitra
mesh_terms: D000212:Acyclovir / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D004952:Esters; D009682:Magnetic Resonance Spectroscopy; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004151:Dipeptides; D004952:Esters; D011355:Prodrugs; D000212:Acyclovir