title: Combined near-infrared spectroscopy and multifrequency bio-impedance investigation of skin alterations in diabetes patients based on multivariate analyses.
abstract: A group of 34 diabetic men, with different degrees of diabetes complications, including skin changes, were studied by near-infrared (NIR) spectroscopy and total body multi-frequency bio-impedance analyses (MFBIA-body). Skin reflectance spectra were measured with a fibre-optic probe in four locations (sites): hand, arm, leg and foot. As control subjects, a group of 23 healthy males were also measured. A combined multivariate analysis of the two types of spectrum was performed. It was concluded that the NIR method has the potential to detect diabetes-related skin conditions and also that the combination of the two techniques provides a higher potential for classification and discrimination of the skin conditions, with correct classification increasing from 63% to 85%.
authors.affiliation: Department of Chemistry, Umeå University, Umeå, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Nyström
authors.forename: B
authors.initials: B
authors.lastname: Lindholm-Sethson
authors.forename: L
authors.initials: L
authors.lastname: Stenberg
authors.forename: S
authors.initials: S
authors.lastname: Ollmar
authors.forename: J W
authors.initials: JW
authors.lastname: Eriksson
authors.forename: P
authors.initials: P
authors.lastname: Geladi
mesh_terms: D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000503:physiopathology*; D017097:Electric Impedance; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012867:Skin / Q000503:physiopathology*; D019265:Spectroscopy, Near-Infrared / Q000379:methods