Design and evaluation of sustained release microspheres of potassium chloride prepared by Eudragit.
The aim of the present work was to prepare and evaluate the sustained release of potassium chloride formulations. Eudragit RS and/or RL loaded with potassium chloride microspheres were prepared by a solvent evaporation method. The effect of sustained release of Eudragit microspheres was evaluated by an in vitro dissolution test and in vivo oral absorption study, and the results were compared to a commercial product (Slow-K). The results showed that Eudragit microspheres loaded with potassium chloride can be easily prepared and satisfactory results obtained considering the size distribution and shapes of microspheres by incorporating aluminum stearate. The encapsulation efficiency and loading capacity were about 84-90% and 27%, respectively. Moreover, the Eudragit RS (30-45 mesh) and Eudragit RS/RL (20-30 mesh) microspheres showed a similar sustained release effect of commercial product via in vitro dissolution and in vivo oral absorption study.
Wu
Pao-Chu
PC
School of Pharmacy, Kaohsiung Medical University, 100 Shih-Chen 1st Road, Kaohsiung 807, Taiwan, ROC. pachwu@kmu.edu.tw
Huang
Yaw-Bin
YB
Chang
Jui-Sheng
JS
Tsai
Ming-Jun
MJ
Tsai
Yi-Hung
YH
D000818:Animals; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000493:pharmacokinetics; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008297:Male; D008863:Microspheres; D011109:Polymethacrylic Acids / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D011189:Potassium Chloride / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D011817:Rabbits; D012995:Solubility
D003692:Delayed-Action Preparations; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D011189:Potassium Chloride