title: A computer model for the study of breast cancer.
abstract: A computer model was designed as a relational database to assess breast cancer screening in a cohort of women where the growth and development of breast cancer originates with the first malignant cell. The concepts of thresholds for growth, axillary spread, and distant sites are integrated. With tumor diagnosis, staging was performed that includes clinical and sub-clinical states. The model was parameterized to have staging characteristics similar to data published by the Surveillance, Epidemiology, and End-Results (SEER) Program. Validation was accomplished by comparing simulated staging results with non-SEER sources, and simulated survival with independent clinical survival data.
authors.affiliation: St. Elizabeth Health Center, The Northeastern Ohio Universities College of Medicine, Youngstown, Rootstown, OH, USA. gcrv44a@zoominternet.net
authors.forename: Kimbroe J
authors.initials: KJ
authors.lastname: Carter
authors.forename: Frank
authors.initials: F
authors.lastname: Castro
authors.forename: Edward
authors.initials: E
authors.lastname: Kessler
authors.forename: Barbara
authors.initials: B
authors.lastname: Erickson
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D015994:Incidence; D008017:Life Expectancy; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis; D018426:SEER Program; D012984:Software; D014481:United States / Q000453:epidemiology