Arginase: marker, effector, or candidate gene for asthma?
Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase I and arginase II activity, in association with IL-4 and IL-13 overexpression, suggesting that arginine pathways are critical in the pathogenesis of asthma.
Vercelli
Donata
D
Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, Arizona 85724-5030, USA. donata@resp-sci.arizona.edu
D000818:Animals; D001119:Arginase / Q000235:genetics*; D001120:Arginine / Q000502:physiology; D001249:Asthma / Q000201:enzymology* / Q000209:etiology / Q000235:genetics*; D020869:Gene Expression Profiling; D005819:Genetic Markers; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008168:Lung / Q000201:enzymology; D051379:Mice; D009569:Nitric Oxide / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis
D005819:Genetic Markers; D007527:Isoenzymes; D009569:Nitric Oxide; D001120:Arginine; D001119:Arginase