title: Colorectal adenocarcinoma in cirrhotic patients.
abstract: BACKGROUND
  Colorectal carcinoma in cirrhotic patients is different from that in patients without the liver disease. The aims of this study were to evaluate the incidence of liver metastasis, postoperative mortality, and the predictors of longterm survival.
  
  
  METHODS
  A retrospective analysis of patients operated on for colorectal adenocarcinoma at the Mayo Clinic, Rochester, MN between 1976 and 2001, with confirmed liver cirrhosis at the time of abdominal exploration.
  
  
  RESULTS
  Seventy-two patients were available for analysis. They were 43% Child A, 42% Child B, and 15% Child C. The median age was 70 (range 42 to 89) years, and the mean duration of followup was 46 months. Postoperative death was 13%. The risk factors were an elevated bilirubin (p = 0.01) and prolonged prothrombin time (p = 0.009). Seven patients (10%) developed liver metastases. For the whole group 1-, 3-, and 5-year survival rates were 69%, 49%, and 35%, respectively. Child A patients had a significantly better survival rate than the combined group of Child B and C patients (p = 0.008). The risks for longterm survival were decreased albumin (p = 0.002) and prolonged prothrombin time (p < 0.001). TNM stage of the carcinoma provided no prognostic information (p = 0.51).
  
  
  CONCLUSIONS
  Liver metastases from colorectal adenocarcinoma is infrequent (10%) in cirrhotic patients. The Child's classification, and not the TNM stage of the carcinoma, predicts the risk of postoperative death and longterm survival.
authors.affiliation: Division of Colon & Rectal Surgery, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Pascal
authors.initials: P
authors.lastname: Gervaz
authors.forename: Rattaplee
authors.initials: R
authors.lastname: Pak-art
authors.forename: Santhat
authors.initials: S
authors.lastname: Nivatvongs
authors.forename: Bruce G
authors.initials: BG
authors.lastname: Wolff
authors.forename: Dirk
authors.initials: D
authors.lastname: Larson
authors.forename: Stacie
authors.initials: S
authors.lastname: Ringel
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology / Q000556:secondary*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D009017:Morbidity; D009367:Neoplasm Staging; D011183:Postoperative Complications / Q000209:etiology; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D016019:Survival Analysis