[Antibiotic sensitivity of Streptococcus pneumoniae in Tunisia: results of a multicenter study (1998-1999)].
We report the results of a multicenter tunisian study, performed over a two-year period (1998-1999), to determine the susceptibility pattern of Streptococcus pneumoniae in our country. A total of 146 S. pneumoniae were collected during the study period. 76 were recovered from adults and 70 from children. 53% of isolates have decreased susceptibility to penicillin, 24% with low level resistance, and 11% with high level resistance. Amoxicillin and cefotaxime decreased susceptibility rates were: 12% (low level resistance exclusively). and 14% (10% with low level resistance and 4% with high level resistance) respectively. Strains isolated from children, showed higher resistance to b lactams than those isolated from adults. Resistance rates to other antibiotics were as follow: erythromycin 28%, choramphenicol 14%, cyclins 23%, thrimethoprim-sulfamethoxazole 28% and rifampin 1%. No vancomycin resistant strain was found. The acquire resistance rates of Streptococcus pneumoniae in Tunisia are worrying, essentially for penicillin and erythomycin. Amoxicillin and cefotaxime have conserved a good activity.
Mahjoubi-Rhimi
Faouzia
F
Laboratoire de Microbiologie, Hôpital d'enfants de Tunis.
Kechrid
Amel
A
Boutiba
Ilhem
I
Mezghani
Senda
S
Kamoun
Aouatef
A
Smaoui
Hanene
H
Thabet
Lamia
L
Ben Redjeb
Saïda
S
Hammami
Adnène
A
D000328:Adult; D000367:Age Factors; D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology; D002648:Child; D002701:Chloramphenicol / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D012189:Retrospective Studies; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology; D014416:Tunisia
D000900:Anti-Bacterial Agents; D010406:Penicillins; D004917:Erythromycin; D002701:Chloramphenicol; D000658:Amoxicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002439:Cefotaxime; D010400:Penicillin G