Difference in effect of myristic and stearic acid on plasma HDL cholesterol within 24 h in young men.
BACKGROUND
There is increasing evidence that postprandial triacylglycerol (TAG)-rich lipoproteins (TRL) may be related to atherogenic risk. Little is known about the acute effect of individual dietary saturated fatty acids on plasma lipids and lipoproteins.


OBJECTIVE
To investigate the effect of two prevalent dietary saturated fatty acids, stearic and myristic acid on postprandial and 24 h fasting plasma lipoprotein TAG and cholesterol concentrations.


METHODS
Ten young healthy men were served two meals (1.2 g fat/kg body weight) containing fat enriched in either stearic acid (S) (shea butter) or myristic acid (M) (produced by inter-esterification) in a randomised, cross-over study. The meals were given in the morning after 12 h of fasting and again after 8 h (in the afternoon). The S and M containing meals were given at different days separated by a washout period. Blood samples were taken before the meal and 2,4,6,8, and 24 h after the first meal.


RESULTS
The M meal resulted in a higher postprandial HDL TAG response than S (P=0.03 I), (diet x time interaction), while no differences were observed in other lipid fractions. Twenty-four hours after the M meal fasting, HDL cholesterol was higher (P=0.05) and HDL TAG lower (P<0.001) than at baseline.


CONCLUSIONS
Intake of individual dietary SFA may affect fasting HDL cholesterol within 24 h. Thus after this short period HDL cholesterol concentration was higher after myristic acid than stearic acid. Myristic acid resulted in a higher increase in postprandial HDL TAG than stearic acid.
Tholstrup
T
T
Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Rolighedsvej 30, DK-1958 Frederiksberg, Denmark. tine.tholstrup@fhe.kvl.dk
Vessby
B
B
Sandstrom
B
B
D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood*; D018592:Cross-Over Studies; D005215:Fasting / Q000097:blood; D006801:Humans; D008297:Male; D019814:Myristic Acid / Q000494:pharmacology*; D019518:Postprandial Period; D013229:Stearic Acids / Q000494:pharmacology*
D008076:Cholesterol, HDL; D013229:Stearic Acids; D019814:Myristic Acid; C031183:stearic acid