[The role of region pX in the life cycle of HTLV-I and in carcinogenesis].
The review considers the molecular biological organization of genome region pX of the human T-cell leukemia virus type I (HTLV-I) along with the structure and functions of regulatory proteins Tax, Rex, and poorly studied Rof and Tof. Tax functions are described, including transcriptional trans-activation, trans-repression, and effects on apoptosis and the cell cycle. The roles of Tax and Rex in controlling gene expression and replication of HTLV-I are discussed.
Susova
O Iu
OIu
Institute of Carcinogenesis, Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478. susovaolga@mail333.com
Gurtsevich
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VE
D004742:Enhancer Elements, Genetic; D015967:Gene Expression Regulation, Viral; D016370:Gene Products, rex / Q000502:physiology; D016356:Gene Products, tax / Q000502:physiology; D015490:HTLV-I Infections / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000821:virology*; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D012191:Retroviridae Proteins; D015682:Retroviridae Proteins, Oncogenic / Q000502:physiology*; D020079:Terminal Repeat Sequences; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D054334:Viral Regulatory and Accessory Proteins; D014779:Virus Replication / Q000502:physiology
D016370:Gene Products, rex; D016356:Gene Products, tax; D016328:NF-kappa B; D012191:Retroviridae Proteins; D015682:Retroviridae Proteins, Oncogenic; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; D054334:Viral Regulatory and Accessory Proteins; C072343:pX protein, Human T-lymphotropic virus 1; C072813:rof protein, Human T-lymphotropic virus 1; C072814:tof protein, Human T-lymphotropic virus 1