title: Intraventricular administration of recombinant tissue plasminogen activator for intraventricular hemorrhage in the newborn.
abstract: Intraventricular hemorrhage remains associated with high mortality and morbidity. Its most serious complication is posthemorrhagic hydrocephalus caused by multiple small blood clots obstructing the arachnoid villi. We treated three newborn infants (one term, two preterm) with posthemorrhagic hydrocephalus using recombinant tissue plasminogen activator, a thrombolytic agent, injected into the ventricles with a spinal needle. Sufficient fibrinolysis was achieved in these preterm patients. They all survived, and shunt surgery was only required in one. No adverse reactions or side effects have occurred. Intraventricular fibrinolysis with tissue plasminogen activator seems to be safe and effective for the treatment of intraventricular hemorrhage. However, controlled studies are needed for assessing treatment efficiency.
authors.affiliation: Department of Pediatrics, Ege University Medical Faculty, 35100 Bornova, Izmir, Turkey. makisu@med.ege.edu.tr
authors.forename: Mete
authors.initials: M
authors.lastname: Akisu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yalaz
authors.forename: Sertac
authors.initials: S
authors.lastname: Arslanoglu
authors.forename: Nilgun
authors.initials: N
authors.lastname: Kultursay
mesh_terms: D002543:Cerebral Hemorrhage / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D007231:Infant, Newborn; D007276:Injections, Intraventricular; D008297:Male; D010960:Plasminogen Activators / Q000008:administration & dosage*; D011994:Recombinant Proteins / Q000008:administration & dosage; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D011994:Recombinant Proteins; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator