Helicobacter pylori antigen-specific T-cell responses at gastric level in chronic gastritis, peptic ulcer, gastric cancer and low-grade mucosa-associated lymphoid tissue (MALT) lymphoma.
Host T-cell response to Helicobacter pylori is important for the clinical outcome of the infection. A Th1-polarized response, preferentially against CagA, is associated with peptic ulcer, whereas mixed Th1 and Th0 responses are present in non-ulcer gastritis. A deregulated H. pylori-driven Th0 cell-dependent B-cell activation is found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue.
D'Elios
Mario M
MM
Department of Internal Medicine, University of Florence, Viale Morgagni 85, 50134 Florence, Italy. delios@unifi.it
Amedei
Amedeo
A
Del Prete
Gianfranco
G
D000942:Antigens, Bacterial / Q000276:immunology; D002908:Chronic Disease; D005753:Gastric Mucosa / Q000276:immunology; D005756:Gastritis / Q000276:immunology; D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000276:immunology; D013272:Stomach Diseases / Q000276:immunology*; D013274:Stomach Neoplasms / Q000276:immunology; D013276:Stomach Ulcer / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000942:Antigens, Bacterial