title: Parallel approach to selective catalysts for palladium-catalyzed desymmetrization of 2,4-cyclopentenediol.
abstract: [reaction: see text] Work toward the development of a bis-phosphine ligand system for the palladium-catalyzed desymmetrization of meso-diols is reported. A parallel approach using phosphine-containing amino acids and a "representational search" was taken to find a polymer-supported catalyst system. The selectivities reported are comparable to many other polymer-bound asymmetric catalysts.
authors.affiliation: Department of Chemistry, Washington University, One Brookings Drive, Campus Box 1134, Saint Louis, Missouri 63130-4899, USA.
authors.forename: Anton
authors.initials: A
authors.lastname: Agarkov
authors.forename: Eric W
authors.initials: EW
authors.lastname: Uffman
authors.forename: Scott R
authors.initials: SR
authors.lastname: Gilbertson
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D002384:Catalysis; D003517:Cyclopentanes / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry; D017433:Protein Structure, Secondary; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000596:Amino Acids; D003517:Cyclopentanes; D009842:Oligopeptides; D009944:Organoplatinum Compounds; D010720:Phosphines