title: Improvement of microcirculation and healing of venous hypertension and ulcers with Crystacide. Evaluation of free radicals, laser Doppler flux and PO2. A prospective-randomized-controlled study.
abstract: In 20 patients with chronic venous insufficiency and venous hypertension associated with ulcerations, the effects of a new compound, applied onto the skin (Crystacide) were assessed in a randomized, controlled study. Duplex scanning was used to assess the presence of venous obstruction and incompetence, and microcirculatory methods were used to assess and quantify venous microangiopathy and to follow up subjects after local treatment with Crystacide. Laser Doppler flowmetry (LDF) was used to assess skin perfusion in association with transcutaneous (tc) partial pressure of oxygen (PO2) measurements. Local plasma free radicals (PFR) were evaluated in the area surrounding the venous ulcer, with the D-Rom test. Crystacide was applied around and on the ulcer for 10 days. Crystacide was more effective than the control treatment: PO2 was increased, PFR and LDF were decreased (flux increase is associated with venous hypertension), and the ulcer area was significantly smaller at 10 days in the Crystacide group in comparison with the placebo group (p<0.05). In conclusion, in venous ulcerations, local treatment with Crystacide (10 days) improves the microcirculation and decreases skin free radicals improving healing.
authors.affiliation: Irvine2 Vascular Laboratory and Physiology, Department of Biomedical Sciences, Chieti University, San Valentino Vascular Screening Project, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Belcaro
authors.forename: M R
authors.initials: MR
authors.lastname: Cesarone
authors.forename: A N
authors.initials: AN
authors.lastname: Nicolaides
authors.forename: G
authors.initials: G
authors.lastname: Geroulakos
authors.forename: A
authors.initials: A
authors.lastname: Di Renzo
authors.forename: M
authors.initials: M
authors.lastname: Milani
authors.forename: A
authors.initials: A
authors.lastname: Ricci
authors.forename: R
authors.initials: R
authors.lastname: Brandolini
authors.forename: M
authors.initials: M
authors.lastname: Dugall
authors.forename: I
authors.initials: I
authors.lastname: Ruffini
authors.forename: U
authors.initials: U
authors.lastname: Cornelli
authors.forename: M
authors.initials: M
authors.lastname: Griffin
mesh_terms: D000368:Aged; D005260:Female; D005609:Free Radicals / Q000097:blood*; D006801:Humans; D006861:Hydrogen Peroxide; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy*; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009824:Ointments; D010100:Oxygen / Q000378:metabolism*; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D018616:Ultrasonography, Doppler, Duplex; D014647:Varicose Ulcer / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014689:Venous Insufficiency / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects
chemical_list: C475179:Crystacide; D005609:Free Radicals; D009824:Ointments; D006861:Hydrogen Peroxide; D010100:Oxygen