title: Stereoselective synthesis of functionalized pyrrolidines by ruthenium porphyrin-catalyzed decomposition of alpha-diazo esters and cascade azomethine ylide formation/1,3-dipolar cycloaddition reactions.
abstract: [reaction: see text] Ruthenium porphyrins catalyze three-component coupling reaction of alpha-diazo esters with a series of N-benzylidene imines and alkenes to form functionalized pyrrolidines in excellent diastereoselectivities. The reaction proceeds via a reactive ruthenium-carbene intermediate and its subsequent reaction with imine to generate azomethine ylide, which reacts with alkenes via 1,3-diploar cycloaddition.
authors.affiliation: Shanghai-Hong Kong Joint Laboratory on Chemical Synthesis, Shanghai Institute of Organic Chemistry, The Chinese Academy of Sciences, 354 Feng Lin Road, Shanghai 200032, China.
authors.forename: Gong-Yong
authors.initials: GY
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Wing-Yiu
authors.initials: WY
authors.lastname: Yu
authors.forename: Wei
authors.initials: W
authors.lastname: Hong
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che