title: Paired-like repression/activation in pituitary development.
abstract: Pituitary gland development is controlled by signals that guide expression of specific combinations of transcription factors that dictate serial determination and differentiation events. One class of factors is paired-like homeodomain factors. Two that have been investigated are the repressor Hex1/Rpx and activator prophet of Pit-1 (Prop-1), which exert selective roles during pituitary development. The opposing actions of these factors provide one aspect of pituitary organogenesis.
authors.affiliation: Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla, California 92093-0648, USA.
authors.forename: Lorin E
authors.initials: LE
authors.lastname: Olson
authors.forename: Jeremy S
authors.initials: JS
authors.lastname: Dasen
authors.forename: Bong Gun
authors.initials: BG
authors.lastname: Ju
authors.forename: Jessica
authors.initials: J
authors.lastname: Tollkuhn
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rosenfeld
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009154:Mutation; D038081:Organogenesis; D010902:Pituitary Gland / Q000196:embryology / Q000254:growth & development*; D000072056:Transcription Factor HES-1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D018398:Homeodomain Proteins; D000072056:Transcription Factor HES-1; C102134:Prophet of Pit-1 protein; C078493:HES1 protein, human