title: Long-term voluntary ethanol drinking increases expression of NMDA receptor 2B subunits in rat frontal cortex.
abstract: Forced ethanol drinking for several days and application of ethanol to cell cultures changes expression levels of various NMDA receptor subunits in rodents. Therefore, we investigated the influence of long-term voluntary ethanol consumption on the expression of NMDA receptor 2B (NR2B) subunits in several forebrain regions of rats [corrected]. This result is in accordance with and extends findings from studies using high doses of ethanol for a short period and suggests that the NR2B might be a potential target for an effective treatment of alcoholic patients.
authors.affiliation: Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, D-80804 Munich, Germany. henninger@mpipsykl.mpg.de
authors.forename: Markus S H
authors.initials: MS
authors.lastname: Henniger
authors.forename: Carsten T
authors.initials: CT
authors.lastname: Wotjak
authors.forename: Sabine M
authors.initials: SM
authors.lastname: Hölter
mesh_terms: D000428:Alcohol Drinking / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000096:biosynthesis* / Q000235:genetics; D013995:Time
chemical_list: C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate