Sesquiterpene constituents from the liverwort Bazzania japonica.
The hydrodistillation products of the liverwort Bazzania japonica were separated by preparative gas chromatography (GC) and investigated by spectroscopic methods. Seven unknown compounds were isolated and identified by GC-MS and NMR. Four of them, the norsesquiterpene hydrocarbons 4-epi-11-nor-aristola-1(10),11-diene (1), 4-epi-11-nor-aristola-1,9,11-triene (2), 4-epi-11-nor-aristola-9,11-diene (3), and one oxygenated sesquiterpene, (-)-aristol-1(10)-en-12-ol (5) are new natural compounds, and one, (+)-himachala-2,4-diene (7), has for the first time been isolated from liverworts. The absolute configurations of 5 and 7 were derived by chemical correlation reactions and/or enantioselective GC using cyclodextrin phases. 1, 2 and 3 have identical absolute configuration.
Lu
Runhua
R
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Key Laboratory for Natural Medicine of Gansu Province, 342 Tianshui Road, Lanzhou 730000, China.
Paul
Claudia
C
Basar
Simla
S
König
Wilfried A
WA
Hashimoto
Toshihiro
T
Asakawa
Yoshinori
Y
D008401:Gas Chromatography-Mass Spectrometry; D035926:Hepatophyta / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000032:analysis* / Q000737:chemistry
D012717:Sesquiterpenes