Effects of dynorphin A(1-13) on DNA synthesis and free radical oxidation in respiratory organs of newborn albino rats pretreated with NG-nitro-L-arginine methyl ester.
Dynorphin A(1-13) increased the number of DNA-synthesizing epitheliocytes in the bronchi and inhibited free radical oxidation in the lungs of newborn albino rats. Pretreatment with NG-nitro-L-arginine methyl ester not only abolished, but also reversed the effect of this peptide.
Lebed'ko
O A
OA
Institute of Maternity and Child Welfare, Khabarovsk Branch, Far-Eastern Research Center for Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Khabarovsk. lebedko@mail.ru
Timoshin
S S
SS
D000701:Analgesics, Opioid / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001980:Bronchi / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D004261:DNA Replication; D004399:Dynorphins / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism*; D008168:Lung / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D032389:Myocytes, Smooth Muscle / Q000187:drug effects* / Q000378:metabolism; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010446:Peptide Fragments / Q000378:metabolism*; D051381:Rats
D000701:Analgesics, Opioid; D004791:Enzyme Inhibitors; D005609:Free Radicals; D010446:Peptide Fragments; C026843:dynorphin (1-13); D004399:Dynorphins; D019331:NG-Nitroarginine Methyl Ester