title: Comparative efficacies of oral ketoconazole and terbinafine for reducing Malassezia population sizes on the skin of Basset Hounds.
abstract: The objective of this study was to compare the efficacy of oral ketoconazole and terbinafine for reducing population sizes of Malassezia yeasts on canine skin. Twenty-one Basset Hounds were randomised in three groups of seven according to Malassezia populations. Dogs in the first group were treated by oral administration of ketoconazole (Ketofungol) 200 mg, Janssen-Cilag) at 10 mg x kg-1, every 24 h with food, for 3 weeks. Dogs in the second group were treated by oral administration of terbinafine (Lamisil) 250 mg, Novartis) at 30 mg x kg-1, every 24 h with food, for 3 weeks. The seven remaining dogs were used as controls. Malassezia population sizes were assessed by use of contact plates on four cutaneous sites at days 7, 14 and 21. Both ketoconazole and terbinafine were effective in reducing the baseline levels of Malassezia organisms with no significant difference between the two drugs. In further studies, oral terbinafine should be evaluated for the management of canine cases of Malassezia dermatitis.
authors.affiliation: Equipe de Mycologie, UMR Biologie Moléculaire et Immunologie Parasitaires et Fongiques, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France. jguillot@vet-alfort.fr
authors.forename: Jacques
authors.initials: J
authors.lastname: Guillot
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bensignor
authors.forename: François
authors.initials: F
authors.lastname: Jankowski
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Seewald
authors.forename: René
authors.initials: R
authors.lastname: Chermette
authors.forename: Jean
authors.initials: J
authors.lastname: Steffan
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D003881:Dermatomycoses / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D005260:Female; D007654:Ketoconazole / Q000008:administration & dosage*; D008290:Malassezia / Q000302:isolation & purification*; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage*; D016037:Single-Blind Method; D000077291:Terbinafine; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine; D007654:Ketoconazole