The effect of the GABAB receptor agonist baclofen on liquid and solid gastric emptying in mice.
The effect of the GABA(B) receptor agonist baclofen, a potential treatment for gastroesophageal reflux, on gastric emptying has not been determined. The effect of 1-4 mg/kg baclofen on liquid and solid gastric emptying in mice was evaluated by noninvasive [13C] breath tests. Baclofen accelerated gastric emptying of solids but delayed emptying of liquid, suggesting that it may have differential effects on proximal and distal stomach emptying.
Symonds
Erin
E
Centre for Paediatric Gastroenterology and Adolescent Gastroenterology, Women's and Children's Hospital, North Adelaide, and Department of Physiology, University of Adelaide, South Australia, Australia. erinsymonds@yahoo.com
Butler
Ross
R
Omari
Taher
T
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D005260:Female; D018755:GABA Agonists / Q000494:pharmacology*; D058786:GABA-B Receptor Agonists; D005746:Gastric Emptying / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018080:Receptors, GABA-B / Q000502:physiology
D018755:GABA Agonists; D058786:GABA-B Receptor Agonists; D018080:Receptors, GABA-B; D001418:Baclofen