Central pontine myelinolysis complicating treatment of multicentric Castleman's disease and Kaposi's sarcoma in a patient with AIDS.
An HIV positive black African woman presented with widespread lymphadenopathy and pancytopenia that had been ascribed to tuberculosis. Lymph node biopsy showed both Kaposi's sarcoma and multicentric Castleman's disease. Despite antiretroviral therapy and chemotherapy the patient deteriorated, developing confusion and dysphasia. A cranial magnetic resonance scan showed central pontine myelinolysis. Despite supportive therapy the patient died.
Apoola
A
A
Department of Genitourinary Medicine, Whittall Street Clinic, Birmingham B4 6DH, UK.
Ross
J
J
Duddy
M J
MJ
Mudaliar
V
V
Jones
E L
EL
Huengsberg
M
M
Miller
R F
RF
D000386:AIDS-Related Complex / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D000328:Adult; D005871:Castleman Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D017590:Myelinolysis, Central Pontine / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D012514:Sarcoma, Kaposi / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed