title: Hyperferritinemia revealing Gaucher's disease.
abstract: Hyperferritinemia is frequently observed during Gaucher's disease but has never been described as an initial manifestation. We report the case of a 57-year-old woman without a previous medical history who presented with hyperferritinemia and IgG monoclonal gammopathy. The diagnostic procedure was negative except for the bone marrow biopsy, which revealed Gaucher's cells. Low beta-glucocerebrosidase activity in leukocytes confirmed the diagnosis of adult Gaucher's disease. We discuss the differential diagnosis and the mechanisms of hyperferritinemia in this disease.
authors.affiliation: Département de Médecine de l'Adulte, Hôpital Sud, 16 boulevard de Bulgarie, 35056 Cedex., Rennes, France
authors.forename: O
authors.initials: O
authors.lastname: Decaux
authors.forename: C
authors.initials: C
authors.lastname: Cazalets
authors.forename: N
authors.initials: N
authors.lastname: Grandgirard
authors.forename: P
authors.initials: P
authors.lastname: Fergelot
authors.forename: P
authors.initials: P
authors.lastname: Jego
authors.forename: B
authors.initials: B
authors.lastname: Grosbois