title: Organoplatinum(II) complexes as a color biomarker in solid-phase peptide chemistry and screening.
abstract: [reaction: see text] A novel organoplatinum(II) biomarker is introduced to facilitate the solid-phase screening of combinatorial libraries for substrates and inhibitors of enzymes and receptors. The robust organoplatinum(II) biomarker can be incorporated, on amine functions, in peptides using standard peptide coupling techniques. The chemistry, stability, and (reversible) coloration process with KI(3) of the organoplatinum(II) biomarker was investigated.
authors.affiliation: Debye Institute, Department of Metal-Mediated Synthesis, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Guillena
authors.forename: Koen M
authors.initials: KM
authors.lastname: Halkes
authors.forename: Gema
authors.initials: G
authors.lastname: Rodríguez
authors.forename: Guido D
authors.initials: GD
authors.lastname: Batema
authors.forename: Gerard
authors.initials: G
authors.lastname: van Koten
authors.forename: Johannis P
authors.initials: JP
authors.lastname: Kamerling
mesh_terms: D000595:Amino Acid Sequence; D015415:Biomarkers / Q000032:analysis / Q000737:chemistry*; D003116:Color; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010455:Peptides / Q000032:analysis* / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D015415:Biomarkers; D009944:Organoplatinum Compounds; D010455:Peptides