Magnetic resonance spectroscopy in pediatric neurology.
In the last three decades a range of non-invasive biophysical techniques have been developed, of which Magnetic Resonance (MR) has proved to be the most versatile. Its non-invasive and safe nature has made it the most important diagnostic and research tool in clinical medicine. MR Spectroscopy (MRS) is the only technique in clinical medicine that provides non-invasive access to living chemistry in situ. This article focuses mainly on proton MRS in brain and also phosphorus MRS in calf muscle, with particular reference to the pediatric population, the normal spectrum and its use in various disease conditions in the practice of pediatric neurology. Few representative case studies among different disease groups have also been detailed.
Gulati
Sheffali
S
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Shah
Tariq
T
Menon
Shaji
S
Jayasundar
Rama
R
Kalra
Veena
V
D000293:Adolescent; D000326:Adrenoleukodystrophy / Q000175:diagnosis; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis; D015415:Biomarkers; D002648:Child; D015140:Dementia, Vascular / Q000175:diagnosis; D003937:Diagnosis, Differential; D003943:Diagnostic Techniques, Neurological; D005260:Female; D005621:Friedreich Ataxia / Q000175:diagnosis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D009422:Nervous System Diseases / Q000175:diagnosis*; D020019:Neurocysticercosis / Q000175:diagnosis; D010372:Pediatrics / Q000379:methods*; D012016:Reference Values
D015415:Biomarkers