CARD15/NOD2 analysis in rheumatoid arthritis susceptibility.
OBJECTIVE
To determine if the mutations in the CARD15/NOD2 gene predisposing to Crohn's disease (CD) contribute also to the genetic susceptibility to rheumatoid arthritis (RA).


METHODS
The frequencies of the three commonest mutations of CARD15/NOD2 predisposing to CD (2104C > T, 2722G>C and 3020insC) were determined in 210 RA patients and 227 controls.


RESULTS
Allelic frequencies of the CARD15/NOD2 mutations in RA patients (2104C>T, 2.8%; 2722G>C, 0.9%; and 3020insC, 2.4%) did not differ significantly from the controls (2104C>T, 5.3%; 2722G>C, 0.7%; and 3020insC, 1.1%).


CONCLUSIONS
There was no evidence of association between the commonest CD CARD15/NOD2 mutations and RA susceptibility.
Ferreirós-Vidal
I
I
Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.
Barros
F
F
Pablos
J L
JL
Carracedo
A
A
Gómez-Reino
J J
JJ
Gonzalez
A
A
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D009154:Mutation / Q000235:genetics*; D053473:Nod2 Signaling Adaptor Protein; D011110:Polymorphism, Genetic
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein