Regulation of cell function by Rho GTPases.
Small GTPases of the Rho family regulate a wide variety of cell functions. In this review, we briefly describe the biological activities of Rho GTPases. Using the Rac-regulated NADPH oxidase as an example, we discuss possible regulatory points that might be exploited for drug development. Finally, we explore strategies for specific targeting of Rho GTPase-regulated signaling pathways.
DerMardirossian
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The Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA.
Bokoch
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