Pesticides and Parkinson's disease.
Parkinson's disease (PD), a common neurodegenerative disorder affects approximately 1% of the population over 65. PD is a late-onset progressive motor disease characterized by tremor, rigidity (stiffness), and bradykinesia (slowness of movement). The hallmark of PD is the selective death of dopamine-containing neurons in the substantia nigra pars compacta which send their projections to the striatum and the presence of cytoplasmic aggregates called Lewy bodies. Most cases of PD are sporadic but rare cases are familial, with earlier onset. The underlying mechanisms and causes of PD still remain unclear.
Sherer
T B
TB
Department of Neurology, Emory University, Atlanta, GA 30322, USA. tsherer@emory.edu
Betarbet
R
R
Greenamyre
J T
JT
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D010300:Parkinson Disease / Q000209:etiology*; D010575:Pesticides / Q000506:poisoning*
D010575:Pesticides