title: Cholesterol and interleukin-6 concentrations relate to outcomes in burn-injured patients.
abstract: The goal of this study was to determine the relationship among lipid concentrations, cytokine concentrations, and clinical outcomes of burn patients. Twenty-eight patients admitted within 24 hours of burn injury, segregated based on burn size, had blood samples drawn 24 and 48 hours after burn injury and then weekly for 3 weeks. Measurements included total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, interleukin (IL)-6, soluble IL-2 receptor, and soluble necrosis factor p55 and p75 receptors. Infection, length of stay (LOS), and survival were monitored. Cholesterol and lipoprotein concentrations decreased by at least 40% in patients with burns >20% total body surface area and inversely correlated with IL-6. Lower cholesterol and higher IL-6 values correlated with higher infection rates and longer LOS. IL-6 was the strongest predictor for LOS. In conclusion, outcomes after burn injury are related to low cholesterol and elevated IL-6 levels.
authors.affiliation: The Rogosin Institute, 505 East 70th Street, New York, NY 10021, USA.
authors.forename: Holly E Colwell
authors.initials: HE
authors.lastname: Vanni
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Gordon
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Levine
authors.forename: Betty-Jane
authors.initials: BJ
authors.lastname: Sloan
authors.forename: David R
authors.initials: DR
authors.lastname: Stein
authors.forename: Roger W
authors.initials: RW
authors.lastname: Yurt
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Saal
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Parker
mesh_terms: D000328:Adult; D000368:Aged; D002056:Burns / Q000097:blood*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009519:New York City; D011379:Prognosis; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D012720:Severity of Illness Index; D016019:Survival Analysis; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007376:Interleukin-2; D015850:Interleukin-6; D018124:Receptors, Tumor Necrosis Factor; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D002784:Cholesterol