Myofibroblastoma of the larynx: a study of two cases.
BACKGROUND
We describe, for the first time, the occurrence of two pure examples of spindle cell neoplasm with fibrous and smooth muscle differentiation in the larynx.


METHODS
Tissue sections from both tumors stained with hematoxylin and eosin were reviewed. Immunophenotypic analysis using keratin, S-100 protein, SMA, and h-Caldesmon markers was performed.


RESULTS
Tumors were seen as raised submucosal nodules in the glottic region of two elderly male patients. Histopathologically, the lesions were unencapsulated and composed of spindle cells that manifested variable cellular anaplasia and expressed SMA and were negative for keratin, S-100, and h-Caldesmon.


CONCLUSIONS
We document histologically low-grade malignant myofibroblastic tumors of the larynx. Complete excision is advised.
MacGregor
Allison R
AR
Department of Otolaryngology, The University of Texas Medical School, Houston, Texas, USA.
Batsakis
John G
JG
El-Naggar
Adel K
AK
D000368:Aged; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D008297:Male; D009379:Neoplasms, Muscle Tissue / Q000473:pathology* / Q000601:surgery