Comparison of intestinal absorption of selected calcium organic salts through the rat jejunum in vitro.
The calcium penetration rates through the rat's ileum were determined for calcium fumarate, calcium gluconate and calcium chloride in solution by means of a set for determination of drug penetration through membranes. The highest penetration rate of calcium was observed for the calcium fumarate solutions, a lower one for calcium gluconate solutions and the lowest--for calcium chloride solutions. The calcium penetration rate was independent from the calcium doses in the studied concentration range. The obtained results suggest that calcium fumarate, till now not used in therapy might find an application in the corrective therapy of calcium deficiency.
Gadomska-Nowak
M
M
Department of Applied Pharmacy and Drug Technology, Silesian Medical Academy, Poland.
Szulc
B
B
Ryszka
F
F
D000818:Animals; D002118:Calcium / Q000378:metabolism; D017610:Calcium Compounds / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000502:physiology*; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D017610:Calcium Compounds; D002118:Calcium