Biocompatibility of fluorinated poly(organophosphazene).
We investigated neutrophil and platelet adhesion on a fluorinated poly(organophosphazene) in vitro. The results suggested that neutrophil and platelet adhesion on the poly(organophosphazene) only occurred on a few occasions, as observed by SEM. We demonstrated that the fluorinated poly(organophosphazene) showed excellent biocompatibility compared with the poly(organophosphazene) without the fluorinated side groups or PDMS. Additionally, we estimated the competitive plasma protein adsorption to the fluorinated poly(organophosphazene) using a gold-colloid-labeled immunoassay. Interestingly, the fluorinated poly(organophosphazene) film selectively adsorbed albumin when compared with gamma-globulin and fibrinogen, suggesting that a selective albumin adsorption on the film is responsible for the suppression of platelet adhesion.
Kanezaki
Shota
S
Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan.
Kawakami
Hiroyoshi
H
Nagaoka
Shoji
S
Kubota
Sunao
S
D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry*; D001792:Blood Platelets / Q000502:physiology; D002448:Cell Adhesion; D005461:Fluorine / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D009504:Neutrophils / Q000166:cytology / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010973:Platelet Adhesiveness; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000378:metabolism
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D009943:Organophosphorus Compounds; D011108:Polymers; D011506:Proteins; D005461:Fluorine