title: Extracardiac anomalies, aneuploidy and growth retardation in 100 consecutive fetal congenital heart defects.
abstract: The importance of extracardiac anomalies in 100 consecutive fetuses with congenital heart disease was evaluated. The most common cardiac diagnoses were hypoplastic left heart syndrome in 35% and atrioventricular canal defect in 15%. Extracardiac anomalies were present in 42%, abnormal karyotype in 19% and intrauterine growth retardation in 20%. There were 45 survivors (35 required neonatal surgery, ten did not require early surgery) and 80% (36/45) of the survivors had isolated congenital heart disease. Extracardiac anomalies and abnormal karyotype were more frequently present in non-survivors (p < 0.001). Also, intrauterine growth retardation was more frequent in non-survivors (p < 0.05).
authors.affiliation: Pennsylvania Hospital, Philadelphia 19107, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Respondek
authors.forename: C N
authors.initials: CN
authors.lastname: Binotto
authors.forename: S
authors.initials: S
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Donnenfeld
authors.forename: S R
authors.initials: SR
authors.lastname: Weil
authors.forename: J C
authors.initials: JC
authors.lastname: Huhta