[Phenotype analysis of alpha1-antichymotrypsin in the Guangzhou Han population].
OBJECTIVE
To understand the phenotype distribution profile of alpha1-antichymotrypsin (alpha1-ACT) in the Han population in Guangzhou municipality so as to decide whether geographical factors affect the distribution of alpha1-ACT phenotypes.


METHODS
Polyacrylamide gel isoelectric focusing followed by immunofixation techniques was employed for examining the alpha1-ACT phenotypes in 200 unrelated individuals randomly selected from the Guangzhou Han residents.


RESULTS
Three phenotypes of alpha1-ACT were identified in this subject cohort, which were identical to those identified in Chongqing but with different distributions of the phenotype frequencies.


CONCLUSIONS
Geographical factors may affect the distribution of the phenotype frequencies of alpha1-ACT, which is a promising genetic marker for the pursuit of human genetics.
Yin
Xiao-juan
XJ
Department of Pediatrics, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
Feng
Zhi-chun
ZC
Li
Qiu-ping
QP
D002681:China / Q000208:ethnology; D005260:Female; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D010641:Phenotype; D000514:alpha 1-Antichymotrypsin / Q000032:analysis / Q000145:classification*
D000514:alpha 1-Antichymotrypsin