title: Detection of the anoxic depolarization of focal ischemia using manganese-enhanced MRI.
abstract: Mismatch between diffusion- and perfusion-weighted MRI was used to indicate a treatable area following focal ischemia, called the penumbra. Activity-induced manganese contrast MRI has been reported as a new visualization method for neural activation using manganese ions as a depolarization-dependent contrast agent. It is well known that energy failure induced by cerebral ischemia produces anoxic depolarization. The purpose of this study was to detect manganese accumulation caused by permanent middle cerebral artery occlusion (MCAO) of rat brain and to compare regional differences between manganese accumulation and decreased apparent diffusion coefficient (ADC). The ratios of signal intensity of manganese-enhanced MRI in the ipsilateral cortex to that in the contralateral cortex were 171.0 +/- 17.5% in MCAO group and 108.4 +/- 13.2% in the sham group. In addition, the enhanced region was much smaller than the area which was detected as having a reduced ADC.
authors.affiliation: Department of Neurosurgery, Meiji University of Oriental Medicine, Kyoto, Japan. aoki@muom.meiji-u.ac.jp
authors.forename: Ichio
authors.initials: I
authors.lastname: Aoki
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ebisu
authors.forename: Chuzo
authors.initials: C
authors.lastname: Tanaka
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Katsuta
authors.forename: Akihiko
authors.initials: A
authors.lastname: Fujikawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Umeda
authors.forename: Masaki
authors.initials: M
authors.lastname: Fukunaga
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Takegami
authors.forename: Erik M
authors.initials: EM
authors.lastname: Shapiro
authors.forename: Shoji
authors.initials: S
authors.lastname: Naruse
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D001931:Brain Mapping / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis* / Q000378:metabolism*; D008297:Male; D008345:Manganese / Q000493:pharmacokinetics*; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values
chemical_list: D008345:Manganese