title: Cyclooxygenase-2 expression in colorectal adenomas.
abstract: OBJECTIVE
  Cyclooxygenase-2 is an important target for nonsteroidal anti-inflammatory drugs in suppressing colorectal tumorigenesis. To evaluate the role of cyclooxygenase-2 in sporadic colorectal adenoma, we correlated cyclooxygenase-2 expression in adenomas with other adenoma characteristics.
  
  
  METHODS
  Cyclooxygenase-2 expression was evaluated immunohistochemically in 95 endoscopically resected colorectal adenomas.
  
  
  RESULTS
  Cyclooxygenase-2 was expressed mainly in the cytoplasm of adenoma cells, where it was seen in 74 percent (70/95) of adenomas. Expression was related significantly to grade of dysplasia (P < 0.001) and tumor size (P = 0.028). Multivariate logistic regression analysis showed cyclooxygenase-2 expression in adenoma cells to be independently associated with grade of dysplasia (P = 0.001).
  
  
  CONCLUSIONS
  Observed associations suggest that cyclooxygenase-2 plays an important role in progression of the adenoma-to-carcinoma sequence.
authors.affiliation: Department of Digestive Surgery, Tokyo Medical and Dental University Graduate School, Japan.
authors.forename: Takanobu
authors.initials: T
authors.lastname: Sato
authors.forename: Keigo
authors.initials: K
authors.lastname: Yoshinaga
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okabe
authors.forename: Takuya
authors.initials: T
authors.lastname: Okawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Enomoto
authors.forename: Touichirou
authors.initials: T
authors.lastname: Takizawa
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sugihara
mesh_terms: D000236:Adenoma / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2; D003593:Cytoplasm / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000378:metabolism*; D016015:Logistic Models; D008565:Membrane Proteins; D015999:Multivariate Analysis; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases