Relationship between human leukocyte antigen status and proliferative diabetic retinopathy in patients with younger-onset type 1 diabetes mellitus.
OBJECTIVE
To investigate the relationship between human leukocyte antigen (HLA) status and proliferative diabetic retinopathy (PDR) to assess the genetic basis of PDR in younger type 1 diabetic patients.


METHODS
Retrospective, nonrandomized, comparative trial.


METHODS
Patients who were diagnosed with type 1 diabetes under 30 years of age (range, 13-28) and had a disease duration of more than 10 years were studied. The patients were divided into two groups: 30 patients who had undergone vitreous surgery younger than 40 years old (the PDR group) and 50 patients without retinopathy (the non-DR group). The duration of diabetes and the level of glycemic control were matched between the two groups. The control group consisted of 50 healthy patients. HLA-A, -B, -C, -DR, and -DQ typing of blood samples was done using the standard microcytotoxicity method.


RESULTS
The frequency of HLA-B62, Cw4, and DQ4 was significantly higher in the PDR group than in the non-DR group (P =.0020, P =.048, and P =.0026, respectively). The Cw4-DR4-DQ4 haplotype frequency was significantly higher in the PDR group than in the control group and the non-DR group (P =.0059).


CONCLUSIONS
Our results suggests that HLA-B62, Cw4, and DQ4 may be useful for predicting the prognosis of retinopathy in patients with younger-onset type 1 diabetes.
Mimura
Tatsuya
T
Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan. mimura@mbg.shere.ne.jp
Funatsu
Hideharu
H
Uchigata
Yasuko
Y
Kitano
Shigehiko
S
Noma
Hidetaka
H
Shimizu
Erika
E
Konno
Yasuhiro
Y
Amano
Shiro
S
Araie
Makoto
M
Yoshino
Osamu
O
Iwamoto
Yasuhiko
Y
Hori
Sadao
S
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003601:Cytotoxicity Tests, Immunologic; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D012189:Retrospective Studies
D001786:Blood Glucose; D006680:HLA Antigens