Chiral discrimination of basic and hydrophobic molecules by chemical force spectroscopy.
Chemical force spectroscopy (CFS) is becoming a powerful technique with which to measure intermolecular forces. The prime advantage over other techniques is the ability to map spatial distribution of ligands on the surface. We have used CFS to explore the binding force of a variety of different chiral molecules in order to understand more about the nature of what is a fundamental aspect of chemical biology and of central importance in pharmacology.
Mahapatro
Mrinal
M
Department of Chemistry, Cambridge University, Lensfield Road, Cambridge, CB2 1EW, UK.
Gibson
Christopher
C
Abell
Chris
C
Rayment
Trevor
T