title: Omental transposition decreases ischemic brain damage examined in a new ischemia model.
abstract: OBJECTIVE
  The aim of this study was to determine whether omental transposition at the time of focal cerebral ischemia can decrease ischemic brain damage produced in dogs, in a new ischemia model, which had been described by us.
  
  
  METHODS
  In group 1 (n = 5), the left internal carotid artery and arterial circle of the brain (posterior communicating artery in humans) were occluded permanently. In group 2 (n = 5), additionally to this ischemia model, omental transposition was performed simultaneously. In the postoperative early period (first 24 h), single photon emission computed tomography (SPECT) and in the late period (72-96 h) SPECT and magnetic resonance imaging (MRI) of the brain were performed. Mann-Whitney U, paired t and Wilcoxon signed rank tests were used for statistical analyses, and p < 0.05 was considered significant.
  
  
  RESULTS
  The dogs had a neurological score (NS) of 3.6 +/- 0.5 and 3.4 +/-0.5 in groups 1 and 2, respectively, in the early period (p > 0.05). In the late period, the dogs had an NS of 4.4 +/- 0.5 and 5.6 +/- 0.5 in groups 1 and 2, respectively (p < 0.05). The NS of each group differed significantly between the early and late period (p < 0.05). Early SPECT imaging showed 50 +/- 7.0% and 52 +/- 8.4% hypoperfusion corresponding to the left middle cerebral artery territory in groups 1 and 2, respectively (p > 0.05). In the late period, the degree of hypoperfusion decreased to 34 +/- 5.5% and 12 +/- 4.8% in groups 1 and 2, respectively (p < 0.05). The degree of hypoperfusion in both groups changed significantly between the early and late period (p < 0.05). In T(1)- and T(2)-weighted MRI images, the volume of the lesion in group 1 was significantly greater than in group 2 (p < 0.001).
  
  
  CONCLUSIONS
  In our new ischemia model, simultaneous omental transposition is helpful in reversing the neurologic deficit and cerebral ischemic damage.
authors.affiliation: Department of General Surgery, Meram Faculty of Medicine, Selçuk University, Konya, Turkey. cvatansev@hotmail.com
authors.forename: C
authors.initials: C
authors.lastname: Vatansev
authors.forename: M E
authors.initials: ME
authors.lastname: Ustün
authors.forename: C O
authors.initials: CO
authors.lastname: Oğün
authors.forename: G
authors.initials: G
authors.lastname: Taştekin
authors.forename: A
authors.initials: A
authors.lastname: Karabacakoğlu
authors.forename: H
authors.initials: H
authors.lastname: Yilmaz
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000601:surgery*; D002548:Cerebral Revascularization / Q000379:methods*; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D004285:Dogs; D008297:Male; D009852:Omentum / Q000601:surgery*; D020521:Stroke / Q000000981:diagnostic imaging / Q000601:surgery; D015899:Tomography, Emission-Computed, Single-Photon