title: Osseointegration in hip prostheses: experimental study in sheep.
abstract: Sixteen 2- to 3-year-old sheep were submitted to a hemiarthroplasty of the hip joint with a specially designed femoral component. The proximal two thirds of the stem had a circumferential, plasma-sprayed, porous coating with hydroxyapatite. The animals where killed a 15, 30, 60, 90, 120, 180, 200, 270, 360, and 540 days after surgery. Femurs were submitted to plain radiographs, computerised tomography (CT) scan, and dual energy X-ray absorptiometry (DEXA). Cross-sections were obtained at four different levels and studied using scanning electron microscopy. In the coated portion of the stem, apposition of woven immature bone was evident at 15-30 days and mature lamellar bone by 30 days. With time, the gap between the endosteum and the coated surface was filled by bridges of lamellar bone with a marked trabecular orientation. In the distal uncoated portion of the stem, the implant was initially surrounded by fibrous tissue that, with time, transformed into lamellar bone.
authors.affiliation: Orthopaedic Department, University of Sassari, Sassari, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Doria
authors.forename: V
authors.initials: V
authors.lastname: De Santis
authors.forename: G
authors.initials: G
authors.lastname: Falcone
authors.forename: L
authors.initials: L
authors.lastname: Proietti
authors.forename: E
authors.initials: E
authors.lastname: De Santis
mesh_terms: D000818:Animals; D019644:Arthroplasty, Replacement, Hip / Q000295:instrumentation; D001672:Biocompatible Materials / Q000494:pharmacology*; D017886:Durapatite / Q000494:pharmacology*; D006621:Hip Joint / Q000502:physiology; D006622:Hip Prosthesis; D023421:Models, Animal; D016348:Osseointegration / Q000187:drug effects* / Q000502:physiology; D012756:Sheep; D016474:Weight-Bearing
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite