Inflammatory breast cancer: vasculogenic mimicry and its hemodynamics of an inflammatory breast cancer xenograft model.
We recently established a new human inflammatory breast cancer (IBC) xenograft (WIBC-9) originating from a patient with IBC. The original tumor and WIBC-9 revealed invasive ductal carcinoma with a hypervascular structure of solid nests and marked lymphatic permeation in the overlying dermis. In the central part of the solid nests, vasculogenic mimicry, which showed an absence of endothelial cells, was observed. Comparison of WIBC-9 with an established non-IBC xenograft (MC-5), using time-course dynamic micro-magnetic resonance angiography analysis (with a newly developed intravascular macromolecular contrast agent for magnetic resonance imaging) demonstrated that the WIBC-9 tumor had blood flow and a vascular mimicry-angiogenesis junction.
Shirakawa
Kazuo
K
Department of Surgery, Kawagoe Medical Center, Saitama Medical School, Saitama, Japan. shirak@saitama-med.ac.jp
Kobayashi
Hisataka
H
Sobajima
Jun
J
Hashimoto
Daijo
D
Shimizu
Atsushi
A
Wakasugi
Hiro
H
D000818:Animals; D001808:Blood Vessels / Q000473:pathology; D001943:Breast Neoplasms / Q000098:blood supply* / Q000235:genetics / Q000473:pathology* / Q000648:ultrastructure; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000473:pathology* / Q000648:ultrastructure; D006439:Hemodynamics / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000235:genetics; D018810:Magnetic Resonance Angiography; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic; D016612:Paraffin Embedding; D013997:Time Factors; D014183:Transplantation, Heterologous / Q000379:methods*; D014407:Tumor Cells, Cultured