title: A simulation model of the oxygen alveolo-capillary exchange in normal and pathological conditions.
abstract: This paper presents a mathematical model of the oxygen alveolo-capillary exchange to provide the capillary oxygen partial pressure profile in normal and pathological conditions. In fact, a thickening of the blood-gas barrier, heavy exercise or a low oxygen partial pressure (PO2) in the alveolar space can reduce the O2 alveolo-capillary exchange. Since the reversible binding between haemoglobin and oxygen makes it impossible to determine the closed form for the mathematical description of the PO2 profile along the pulmonary capillaries, an approximate analytical solution of the capillary PO2 profile is proposed. Simulation results are compared with the capillary PO2 profile obtained by numerical integration and by a piecewise linear interpolation of the oxyhaemoglobin dissociation curve. Finally, the proposed model is evaluated in a large range of physiopathological diffusive conditions. The good fit to numerical solutions in all experimental conditions seems to represent a substantial improvement with respect to the approach based on a linear approximation of the oxyhaemoglobin dissociation curve, and makes this model a candidate to be incorporated into the integrated descriptions of the entire respiratory system, where the datum of primary interest is the value of end capillary PO2.
authors.affiliation: Biomedical Engineering Unit, Department of Electronics, Computer Science and Systems (DEIS), University of Bologna, Viale Risorgimento 2, 1-40136 Bologna, Italy. cbrighenti@deis.unibo.it
authors.forename: Chiara
authors.initials: C
authors.lastname: Brighenti
authors.forename: Gianni
authors.initials: G
authors.lastname: Gnudi
authors.forename: Guido
authors.initials: G
authors.lastname: Avanzolini
mesh_terms: D002196:Capillaries / Q000378:metabolism; D003198:Computer Simulation; D006801:Humans; D008171:Lung Diseases / Q000378:metabolism* / Q000503:physiopathology*; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism; D010108:Oxyhemoglobins / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000378:metabolism; D011652:Pulmonary Circulation / Q000502:physiology; D011659:Pulmonary Gas Exchange / Q000502:physiology*
chemical_list: D010108:Oxyhemoglobins; D010100:Oxygen