title: Effect of vitamin C, E-acetate and beta-carotene on the cytostatic activity of nicotinamide (vitamin B3).
abstract: From experiments in vitro (E. coli bacteria AB 1157) it was established that the cytostatic activity of nicotinamide (vitamin B3) in aqueous, aerated media (pH = 7.4) under irradiation with gamma-rays can be strongly enhanced in the presence of antioxidant vitamins. Whereas the addition of beta-carotene (beta-car) increases nicotinamide activity by a factor of 1.7, vitamin E (vit.E) of 2.16 and vitamin C (vit.C) of 2.3, in the presence of all three vitamins (beta-car, vit.E and C) a four times enhancement is observed. This ability of the vitamins to affect so strongly the cytostatic properties of nicotinamide is of interest for the radiation therapy of patients.
authors.affiliation: Ludwig Boltzmann Institute for Radiation Chemistry and Radiation Biology, University of Vienna, Althanstr. 14, A-1090 Wien, Austria.
authors.forename: Nikola
authors.initials: N
authors.lastname: Getoff
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000528:radiation effects; D005720:Gamma Rays; D009536:Niacinamide / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology; D024505:Tocopherols; D024502:alpha-Tocopherol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D019207:beta Carotene / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D011838:Radiation-Sensitizing Agents; D019207:beta Carotene; D009536:Niacinamide; D024502:alpha-Tocopherol; D001205:Ascorbic Acid; D024505:Tocopherols