title: Functional development of small intestine of Japanese quail hatched on MIR orbital station.
abstract: The effect of microgravity on functional development of the small intestine of Japanese quails incubated for 2-3 d and hatched on the orbital station MIR was examined. After 5 d of space flight duodenal and jejunal alkaline phosphatase (AP) activity of the experimental group was compared with the AP activity in quails of the same age hatched on the Earth (laboratory controls). Short-term microgravity leading to decreased food intake resulted in significant increase of AP activity in both duodenal and jejunal enterocytes (P<0.001) of the experimental quails. The results suggest that increased AP activity probably reflects the delayed functional development of the small intestine as a consequence of inappropriate food intake during non-physiological conditions of space flight.
authors.affiliation: University of Veterinary Medicine, Kosice, Slovak Republic.
authors.forename: L
authors.initials: L
authors.lastname: Lenhardt
authors.forename: V
authors.initials: V
authors.lastname: Cigankova
authors.forename: M
authors.initials: M
authors.lastname: Zibrin
authors.forename: J
authors.initials: J
authors.lastname: Kocisova
authors.forename: I
authors.initials: I
authors.lastname: Tomkova
authors.forename: V
authors.initials: V
authors.lastname: Sabo
authors.forename: K
authors.initials: K
authors.lastname: Boda
authors.forename: O A
authors.initials: OA
authors.lastname: Dadasheva
authors.forename: T S
authors.initials: TS
authors.lastname: Gurieva
authors.forename: S
authors.initials: S
authors.lastname: Mozes
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D003370:Coturnix / Q000254:growth & development* / Q000378:metabolism; D004386:Duodenum / Q000201:enzymology / Q000254:growth & development* / Q000378:metabolism; D004435:Eating; D020895:Enterocytes / Q000201:enzymology / Q000378:metabolism / Q000502:physiology; D007583:Jejunum / Q000201:enzymology / Q000254:growth & development* / Q000378:metabolism; D013026:Space Flight; D014893:Weightlessness
chemical_list: D000469:Alkaline Phosphatase