Stacking conformation of 9-[omega-(thymin-1-yl)alkyl]adenine in aqueous solution.
An intramolecular stacking between adenine and thymine rings of 9-[omega-(thymin-1-yl)alkyl]adenine was investigated by means of NMR and UV spectroscopy. The stacking conformation was presumed on the basis of the temperature dependence on the chemical shifts of the adenine and thymine ring protons in the buffer solution at pD 7.0.
Itahara
Toshio
T
Department of Bioengineering, Faculty of Engineering, Kagoshima University, Korimoto, Kagoshima, Japan. Itahara@be.kagoshima-u.ac.jp
D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D011119:Polynucleotides / Q000737:chemistry; D011522:Protons; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D013941:Thymine / Q000737:chemistry; D014867:Water / Q000737:chemistry*
D011119:Polynucleotides; D011522:Protons; D014867:Water; D004247:DNA; D000225:Adenine; D013941:Thymine