title: Essential tremor is not associated with alpha-synuclein gene haplotypes.
abstract: A specific allele of the NACP-Rep1 polymorphism within the alpha-synuclein promoter was found to be associated both with Parkinson's disease and essential tremor. We repeated the association study on a large series of Italian patients with essential tremor using a panel of polymorphisms within the alpha-synuclein gene. Our results did not confirm the association reported previously and failed to identify a alpha-synuclein specific haplotype as susceptibility factor for essential tremor.
authors.affiliation: Department of Neurosciences, Ophthalmology and Genetics-Section of Medical Genetics, University of Genova, Genova, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Pigullo
authors.forename: Emilio
authors.initials: E
authors.lastname: Di Maria
authors.forename: Roberta
authors.initials: R
authors.lastname: Marchese
authors.forename: Emilia
authors.initials: E
authors.lastname: Bellone
authors.forename: Rossella
authors.initials: R
authors.lastname: Gulli
authors.forename: Cesa
authors.initials: C
authors.lastname: Scaglione
authors.forename: Stella
authors.initials: S
authors.lastname: Battaglia
authors.forename: Paolo
authors.initials: P
authors.lastname: Barone
authors.forename: Paolo
authors.initials: P
authors.lastname: Martinelli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Abbruzzese
authors.forename: Franco
authors.initials: F
authors.lastname: Ajmar
authors.forename: Paola
authors.initials: P
authors.lastname: Mandich
mesh_terms: D000368:Aged; D000483:Alleles; D020329:Essential Tremor / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics; D051843:Synucleins; D051844:alpha-Synuclein
chemical_list: D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein