title: MAX4 and RMS1 are orthologous dioxygenase-like genes that regulate shoot branching in Arabidopsis and pea.
abstract: Shoot branching is inhibited by auxin transported down the stem from the shoot apex. Auxin does not accumulate in inhibited buds and so must act indirectly. We show that mutations in the MAX4 gene of Arabidopsis result in increased and auxin-resistant bud growth. Increased branching in max4 shoots is restored to wild type by grafting to wild-type rootstocks, suggesting that MAX4 is required to produce a mobile branch-inhibiting signal, acting downstream of auxin. A similar role has been proposed for the pea gene, RMS1. Accordingly, MAX4 and RMS1 were found to encode orthologous, auxin-inducible members of the polyene dioxygenase family.
authors.affiliation: Department of Biology, University of York, York, YO10 5YW, United Kingdom.
authors.forename: Karim
authors.initials: K
authors.lastname: Sorefan
authors.forename: Jon
authors.initials: J
authors.lastname: Booker
authors.forename: Karine
authors.initials: K
authors.lastname: Haurogné
authors.forename: Magali
authors.initials: M
authors.lastname: Goussot
authors.forename: Katherine
authors.initials: K
authors.lastname: Bainbridge
authors.forename: Eloise
authors.initials: E
authors.lastname: Foo
authors.forename: Steven
authors.initials: S
authors.lastname: Chatfield
authors.forename: Sally
authors.initials: S
authors.lastname: Ward
authors.forename: Christine
authors.initials: C
authors.lastname: Beveridge
authors.forename: Catherine
authors.initials: C
authors.lastname: Rameau
authors.forename: Ottoline
authors.initials: O
authors.lastname: Leyser
mesh_terms: D017360:Arabidopsis / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D029681:Arabidopsis Proteins / Q000235:genetics / Q000502:physiology*; D003001:Cloning, Molecular; D004251:DNA Transposable Elements; D018506:Gene Expression Regulation, Plant; D007210:Indoleacetic Acids / Q000494:pharmacology; D009154:Mutation; D010105:Oxygenases / Q000235:genetics / Q000502:physiology*; D018532:Pisum sativum / Q000235:genetics; D010802:Phylogeny; D018517:Plant Roots / Q000235:genetics / Q000254:growth & development; D018520:Plant Shoots / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D029681:Arabidopsis Proteins; D004251:DNA Transposable Elements; D007210:Indoleacetic Acids; C475746:MAX4 protein, Arabidopsis; D010105:Oxygenases; C475747:RMS1 protein, pea