Four new cycloartane glycosides from Aquilegia vulgaris and their immunosuppressive activities in mouse allogeneic mixed lymphocyte reaction.
Four new cycloartane glycosides, named aquilegiosides C-F, were isolated from the dried aerial parts of Aquilegia vulgaris. Their structures were determined by two dimensional (2D) NMR spectroscopic analysis and chemical evidence. Aquilegiosides C-F suppressed the proliferation of lymphocytes in mouse allogeneic mixed lymphocyte reaction with IC(50), ranging from 3.7x10(-5) to 2.2x10(-4) M.
Nishida
Makiko
M
Faculty of Engineering, Kyushu Kyoritsu University, Kitakyushu, Japan.
Yoshimitsu
Hitoshi
H
Okawa
Masafumi
M
Nohara
Toshihiro
T
D000818:Animals; D031884:Aquilegia / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects / Q000276:immunology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry*
D006027:Glycosides; D007166:Immunosuppressive Agents; D010936:Plant Extracts; D014315:Triterpenes; C085352:cycloartane