Influence of anti-thymocyte globulin as part of the conditioning regimen on immune reconstitution following matched related bone marrow transplantation.
The aim of this work was to analyze the influence of anti-thymocyte globulin (ATG) as part of the conditioning regimen on immune reconstitution following matched related bone marrow transplantation. The rate and pattern of the recovery of total lymphocytes, natural killer (NK) cells, and several T and B cell subsets were determined in 38 patients for more than 2 years following BMT. We compared two patient groups: the first comprised 19 patients after matched related BMT without ATG prevention for graft-versus-host disease (GVHD) and the second contained 19 patients after matched related BMT with ATG treatment for GVHD prophylaxis. We observed impaired immune reconstitution in the ATG group in comparison with the non-ATG group, indicating a significant influence of ATG on immune recovery for several months after BMT.
Fehse
Natalja
N
Bone Marrow Transplantation, University Hospital Eppendorf, Hamburg, Germany. nfehse@uke.uni-hamburg.de
Fehse
Boris
B
Kröger
Nicolaus
N
Zabelina
Tatjana
T
Freiberger
Petra
P
Krüger
William
W
Kabisch
Hartmut
H
Erttmann
Rudolf
R
Zander
Axel R
AR
D000293:Adolescent; D000328:Adult; D000961:Antilymphocyte Serum / Q000008:administration & dosage* / Q000494:pharmacology; D016026:Bone Marrow Transplantation / Q000379:methods*; D005260:Female; D005434:Flow Cytometry; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D007700:Kinetics; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets; D008297:Male; D008875:Middle Aged; D012038:Regeneration; D035781:Siblings; D019172:Transplantation Conditioning / Q000379:methods*; D014185:Transplantation, Isogeneic
D000961:Antilymphocyte Serum