title: MR imaging and spectroscopy of a tuber cinereum hamartoma in a patient with growth hormone deficiency and hypogonadotropic hypogonadism.
abstract: To our knowledge, this is the first report of hypogonadotropic hypogonadism, or growth hormone deficiency, in a patient without non-Pallister-Hall syndrome who had hypothalamic hamartoma diagnosed on the basis of MR imaging and MR spectroscopy findings. On short-TE proton MR spectra, the N-acetylaspartate concentration in the hamartoma was lower than that in the thalamus but similar to that in the amygdala. However, myo-inositol concentration was elevated in the hamartoma compared with that in the amygdala and thalamus. This report stresses the advantages of short-TE spectroscopy and demonstrates that regional variations in spectra should be considered when reference structures are used.
authors.affiliation: Section for Pediatric Endocrinology, University of Tübingen, 72076 Tübingen, Germany.
authors.forename: David D
authors.initials: DD
authors.lastname: Martin
authors.forename: Uwe
authors.initials: U
authors.lastname: Seeger
authors.forename: Michael B
authors.initials: MB
authors.lastname: Ranke
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Grodd
mesh_terms: D000293:Adolescent; D000679:Amygdala / Q000473:pathology; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D003937:Diagnosis, Differential; D006065:Gonadotropins, Pituitary / Q000172:deficiency*; D006222:Hamartoma / Q000151:congenital* / Q000175:diagnosis; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis*; D007027:Hypothalamic Diseases / Q000151:congenital* / Q000175:diagnosis; D007294:Inositol / Q000032:analysis; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013788:Thalamus / Q000473:pathology; D014371:Tuber Cinereum / Q000473:pathology*
chemical_list: D006065:Gonadotropins, Pituitary; D019382:Human Growth Hormone; D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline