Use of HLDF-6 peptide for correction of disturbances in the endogenous opioid system in offspring of morphine-tolerant animals.
We studied the effect of bioactive peptide HLDF-6 on functional activity of the endogenous antinociceptive system in the offspring of morphine-tolerant animals. Disturbances in this system included changes in the thermonociceptive threshold and enkephalinase A activity in various brain structures. The peptide acted as a potent regulator of the homeostasis in systems responsible for the synthesis and catabolism of endogenous opioids. HLDF-6 effectively corrected disorders of the endogenous antinociceptive system.
Litvinova
S V
SV
Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov Moscow State University.
Kostanyan
I A
IA
Aristova
V V
VV
Kalyuzhnyi
A L
AL
Shul'govskii
V V
VV
Terebilina
N N
NN
Panchenko
L F
LF
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism; D004361:Drug Tolerance / Q000502:physiology*; D005260:Female; D006706:Homeostasis; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009294:Narcotics / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D015260:Neprilysin / Q000037:antagonists & inhibitors / Q000378:metabolism; D010146:Pain / Q000378:metabolism*; D010147:Pain Measurement; D010446:Peptide Fragments / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D009294:Narcotics; D009363:Neoplasm Proteins; D010446:Peptide Fragments; C091149:cell differentiation factor 8.2-kDa; D009020:Morphine; D015260:Neprilysin