title: Clubbed fingers and hypertrophic osteoarthropathy in a patient with squamous cell carcinoma of the lung.
abstract: Hypertrophic osteoarthropathy (HOA) is characterized by clubbed fingers and periosteal new bone formation. Etiologically, it can be divided into primary and secondary HOA, but its pathogenesis is uncertain. We report a 42-year-old male patient who suffered from painful clubbing fingers and toes. Serial examinations revealed periosteal new bone formation in the four limb long bones and a solid mass lesion in the right upper lung field. Pathologic examination of the resected mass lesion showed squamous cell carcinoma. After surgery and chemotherapy, the severity of clubbed fingers decreased and joint pain improved. Follow-up bone scan also suggested regression of the uptake of radioactivity in the four limb bones. We concluded that the HOA in this case was probably caused by lung cancer.
authors.affiliation: Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Wen-Chi
authors.initials: WC
authors.lastname: Yang
authors.forename: Shih-Chang
authors.initials: SC
authors.lastname: Lin
authors.forename: Ta-Chih
authors.initials: TC
authors.lastname: Liu
authors.forename: Chung-Jen
authors.initials: CJ
authors.lastname: Chen
authors.forename: Jeng-Hsien
authors.initials: JH
authors.lastname: Yen
authors.forename: Tsan-Teng
authors.initials: TT
authors.lastname: Ou
authors.forename: Hong-Wen
authors.initials: HW
authors.lastname: Liu
authors.forename: Wen-Chan
authors.initials: WC
authors.lastname: Tsai
mesh_terms: D000328:Adult; D001846:Bone Development; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000601:surgery; D008297:Male; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000209:etiology*; D011877:Radionuclide Imaging