Molecular mechanisms of dendritic cell sublineage development from human hematopoietic progenitor/stem cells.
In vitro differentiation models of human CD34+ hematopoietic progenitor/stem cells have contributed significantly to our current understanding of dendritic cell (DC) development. DC sublineages seem to arise from common progenitors with monocytic cells. These progenitors seem to respond to instructive signals from cytokine receptors and steroids to follow defined sublineage differentiation pathways. Transcriptional processes involved in the regulation of lineage fate decisions of putative common DC progenitors remain poorly defined, as is our knowledge of the identities of DC precursors in vivo. Most likely, tissue-specific microenvironmental signals, including tumor-derived signals, critically modulate DC phenotype and function in vivo.
Strobl
Herbert
H
Institute of Immunology, University of Vienna, Vienna, Austria. herbert.strobl@univie.ac.at
D000818:Animals; D018952:Antigens, CD34 / Q000276:immunology; D002117:Calcitriol / Q000276:immunology / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology / Q000502:physiology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000276:immunology; D006410:Hematopoiesis / Q000276:immunology / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology / Q000502:physiology; D008565:Membrane Proteins; D023421:Models, Animal; D038042:Myelopoiesis / Q000276:immunology / Q000502:physiology*; D051880:Receptors, Notch; D015398:Signal Transduction / Q000276:immunology / Q000502:physiology; D015291:Transforming Growth Factors / Q000276:immunology; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D018952:Antigens, CD34; D008565:Membrane Proteins; D051880:Receptors, Notch; D014409:Tumor Necrosis Factor-alpha; D015291:Transforming Growth Factors; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D002117:Calcitriol