title: Generation of food-grade lactococcal starters which produce the lantibiotics lacticin 3147 and lacticin 481.
abstract: Transconjugant lactococcal starters which produce both lantibiotics lacticin 3147 and lacticin 481 were generated via conjugation of large bacteriocin-encoding plasmids. A representative of one of the resultant strains proved more effective at killing Lactobacillus fermentum and inhibiting the growth of Listeria monocytogenes LO28H than either of the single bacteriocin-producing parental strains, demonstrating the potential of these transconjugants as protection cultures for food safety applications.
authors.affiliation: Dairy Products Research Centre, Teagasc, Moorepark, Fermoy, County Cork, Republic of Ireland.
authors.forename: Lisa
authors.initials: L
authors.lastname: O'Sullivan
authors.forename: Maire P
authors.initials: MP
authors.lastname: Ryan
authors.forename: R Paul
authors.initials: RP
authors.lastname: Ross
authors.forename: Colin
authors.initials: C
authors.lastname: Hill
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000494:pharmacology; D001430:Bacteriocins; D002611:Cheese / Q000382:microbiology*; D003227:Conjugation, Genetic; D007778:Lactobacillus / Q000187:drug effects; D013294:Lactococcus lactis / Q000235:genetics* / Q000378:metabolism; D008089:Listeria monocytogenes / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010957:Plasmids
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001430:Bacteriocins; C082508:lacticin 481