title: Evolution of the protein repertoire.
abstract: Most proteins have been formed by gene duplication, recombination, and divergence. Proteins of known structure can be matched to about 50% of genome sequences, and these data provide a quantitative description and can suggest hypotheses about the origins of these processes.
authors.affiliation: Structural Studies Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
authors.forename: Cyrus
authors.initials: C
authors.lastname: Chothia
authors.forename: Julian
authors.initials: J
authors.lastname: Gough
authors.forename: Christine
authors.initials: C
authors.lastname: Vogel
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Teichmann
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D002384:Catalysis; D019295:Computational Biology; D004798:Enzymes / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D019143:Evolution, Molecular; D020440:Gene Duplication; D016678:Genome; D006801:Humans; D008660:Metabolism; D009154:Mutation; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D011995:Recombination, Genetic; D013379:Substrate Specificity
chemical_list: D004798:Enzymes; D011506:Proteins