title: Influence of pH drop on both nisin and pediocin production by Lactococcus lactis and Pediococcus acidilactici.
abstract: OBJECTIVE
  To develop a kinetic model for describing the specific effect of pH drop on nisin and pediocin production in whey.
  
  
  RESULTS
  The effect of pH drop on both bacteriocin productions was tested in non-buffered whey and whey buffered at initial pH 6.3 with 0.03, 0.10 and 0.25 mol l-1 of potassium hydrogen phthalate-NaOH. An accurate description of the experimental data of nisin and pediocin obtained at different pH drops is obtained with the proposed model.
  
  
  CONCLUSIONS
  The proposed model was able to typify both bacteriocins as pH-dependent primary metabolites.
  
  
  CONCLUSIONS
  The decisive role of pH drop for bacteriocin production on whey was demonstrated and modelled. This study contributes to a better understanding of underlying metabolic regulatory mechanisms, which could facilitate the optimization of bacteriocin production for upscaling.
authors.affiliation: Department of Biochemistry, Genetics and Immunology, Vigo University, Ourense, Spain.
authors.forename: N P
authors.initials: NP
authors.lastname: Guerra
authors.forename: L
authors.initials: L
authors.lastname: Pastrana
mesh_terms: D001430:Bacteriocins / Q000032:analysis / Q000096:biosynthesis*; D003470:Culture Media; D006863:Hydrogen-Ion Concentration; D013294:Lactococcus lactis / Q000378:metabolism*; D008433:Mathematics; D009561:Nisin / Q000032:analysis / Q000096:biosynthesis*; D010376:Pediococcus / Q000378:metabolism*
chemical_list: D001430:Bacteriocins; D003470:Culture Media; D009561:Nisin