Coagulation factor VIII: structure and stability.
Factor VIII (FVIII), a coagulation factor in the blood, is one of the most complex proteins known today. To facilitate the rapid development of a more convenient and safer FVIII product and to improve the quality of life for hemophilia patients, this short article reviews the recent investigations on the structure, activity, and more importantly, stability of FVIII.
Wang
Wei
W
Analytics & Formulation, Biotechnology Division, Bayer Healthcare, 800 Dwight Way, Berkeley, CA 94701, USA. wei.wang@bayer.com
Wang
Y John
YJ
Kelner
Drew N
DN
D000818:Animals; D002626:Chemistry, Pharmaceutical; D004349:Drug Packaging; D004355:Drug Stability; D005169:Factor VIII / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D011487:Protein Conformation
D005169:Factor VIII