Effects of oxytocin and prostaglandin F(2alpha) (enzaprost) on platelet aggregation.
The effects of uterotonic agents (oxytocin and enzaprost) on platelet aggregation in pregnant and nonpregnant women were studied by low-angle light scattering. In nonpregnant women oxytocin produced different effects on ADP-induced platelet aggregation: potentiation at low (<200 nM) and inhibition at high (>400 nM) ADP concentrations. In pregnant women oxytocin did not modulate ADP-induced platelet aggregation or this effect was negligible. Enzaprost competitively inhibited ADP-induced platelet aggregation in all examined women (inhibition constant 84.8+/-25.7 nM).
Ailamazyan
E K
EK
I. P. Pavlov St. Petersburg State Medical University.
Petrishchev
N N
NN
Vivulanets
E V
EV
Maryutina
L V
LV
Mindukshev
I V
IV
Khachaturyan
A R
AR
D000244:Adenosine Diphosphate / Q000494:pharmacology; D015237:Dinoprost / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007743:Labor, Obstetric / Q000097:blood; D010120:Oxytocics / Q000009:adverse effects / Q000494:pharmacology*; D010121:Oxytocin / Q000009:adverse effects / Q000494:pharmacology*; D015539:Platelet Activation / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects*; D011247:Pregnancy; D014592:Uterine Hemorrhage / Q000209:etiology / Q000517:prevention & control
D010120:Oxytocics; D010121:Oxytocin; D000244:Adenosine Diphosphate; D015237:Dinoprost