Calcium signalling in lymphocytes.
The modulation of intracellular calcium ion concentration, [Ca(2+)](i), is a common signalling mechanism used in many biological systems. B and T lymphocytes rely on Ca(2+) signalling to initiate both developmental and activation programs. Recent data has shed new light on the initiation of this signalling pathway, the connection between the release of intracellular Ca(2+) stores and the influx of extracellular Ca(2+), and the molecular identity of the elusive Ca(2+) release-activated Ca(2+) (CRAC) channel. In addition, recent gene profiling of T lymphocytes has identified the genes that are controlled by [Ca(2+)](i) and the Ca(2+)-dependent phosphatase calcineurin.
Winslow
Monte M
MM
Program in Immunology and the Howard Hughes Medical Institute, Stanford University, Stanford CA 94305, USA. mwinslow@stanford.edu
Neilson
Joel R
JR
Crabtree
Gerald R
GR
D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D002450:Cell Communication; D006801:Humans; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018448:Models, Immunological; D020411:Oligonucleotide Array Sequence Analysis; D011946:Receptors, Antigen / Q000502:physiology; D010738:Type C Phospholipases / Q000378:metabolism
D011946:Receptors, Antigen; D010738:Type C Phospholipases; D002118:Calcium