Biology of FasL.
FasL (CD95L) is a well-known and well-characterized death-inducing ligand. Spontaneous mutations in FasL and its cognate receptor Fas (CD95) have helped understand the role of these molecules in the disease. Once thought to be mainly involved in the homeostasis of immune system, the territory of FasL regulation has been expanded to angiogenesis and tumor progression. Here, we review what is currently known about the role of FasL in many areas of biology.
Lee
Hae-ock
HO
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA.
Ferguson
Thomas A
TA
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis; D003602:Cytotoxicity, Immunologic; D053222:Fas Ligand Protein; D006706:Homeostasis; D006801:Humans; D007108:Immune Tolerance; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains; D018448:Models, Immunological; D009154:Mutation; D009369:Neoplasms / Q000276:immunology; D009389:Neovascularization, Pathologic; D013601:T-Lymphocytes / Q000276:immunology
D001323:Autoantibodies; C505661:FASLG protein, human; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D008562:Membrane Glycoproteins