title: Low leucocyte myeloperoxidase activity in patients with multiple sclerosis.
abstract: The gene for myeloperoxidase (MPO) has been implicated in multiple sclerosis (MS). By measuring H(2)O(2) dependent oxidation of 3,3'5,5'-tetramethylbenzidine with spectrophotometry the authors investigated MPO activity in peripheral blood leucocytes from 42 patients with MS (12 with secondary progressive MS, 17 with primary progressive MS, and 13 with relapsing remitting benign MS) and 32 healthy controls. Leucocyte MPO activity was significantly lower in patients with benign MS (mean (SEM) 0.086 (0.029) U/mg protein; p<0.01), secondary progressive MS (0.038 (0.009) U/mg protein; p<0.001), and primary progressive MS (0.057 (0.016) U/mg protein; p<0.001) compared with healthy controls (0.322 (0.053) U/mg protein). These data suggest that low MPO, which may be genetically determined, plays a part in MS pathogenesis.
authors.affiliation: Department of Neurology, Academisch Ziekenhuis Groningen, Groningen, Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Ramsaransing
authors.forename: A
authors.initials: A
authors.lastname: Teelken
authors.forename: V M
authors.initials: VM
authors.lastname: Prokopenko
authors.forename: A V
authors.initials: AV
authors.lastname: Arutjunyan
authors.forename: J
authors.initials: J
authors.lastname: De Keyser
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics / Q000503:physiopathology*; D009195:Peroxidase / Q000235:genetics / Q000494:pharmacology*; D012720:Severity of Illness Index
chemical_list: D009195:Peroxidase