Evaluation of soluble intracellular adhesion molecule-1 (sICAM-1) in benign and malignant ovarian masses.
OBJECTIVE
To evaluate serum ICAM-1 levels preoperatively in patients with ovarian masses.


METHODS
Estimation by ELISA assay in 101 women with pelvic tumours and 16 healthy controls was performed. Correlations of sICAM-1 levels with CA-125, Tumour Volume Index, morphological score and pathological findings were studied.


RESULTS
Fifty-one ovarian tumours were malignant, five were borderline and 45 benign. Mean levels of sICAM-1 were respectively, 311.1 +/- 182.9 ng/ml, 172.6 +/- 40.1 ng/ml, 241.8 +/- 74.1 ng/ml and 195.6 +/- 68.7 ng/ml for controls. The area under ROC curve for sICAM-1 was 0.72 (95% CI 0.58-0.82), the cut-off 250 ng/ml, corresponding to 81.3% sensitivity and 52.9% specificity. Serum ICAM-1 correlated with morphological score (r = 0.51, p < 0.001), but not with FIGO stage, tumour grade, Tumour Volume Index and CA-125.


CONCLUSIONS
sICAM-1 concentrations are higher in patients with malignant tumours, but poorly correlate with clinical status. The clinical use alone in ovarian malignancy detection and tumour differentiation seems to have limited application. Combinations of CA-125 and sICAM-1 could improve the test characteristics.
Opala
T
T
Department of Mother's and Child's Health, Karol-Marcinkowski University of Medical Sciences, Poznan, Poland.
Drews
K
K
Rzymski
P
P
Woźniak
J
J
Sajdak
S
S
D014408:Biomarkers, Tumor / Q000097:blood; D001707:Biopsy, Needle; D016022:Case-Control Studies; D016001:Confidence Intervals; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis / Q000097:blood*; D009367:Neoplasm Staging; D010049:Ovarian Diseases / Q000473:pathology / Q000601:surgery; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery*; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D012372:ROC Curve; D012016:Reference Values; D012680:Sensitivity and Specificity; D012995:Solubility
D014408:Biomarkers, Tumor; D018799:Intercellular Adhesion Molecule-1