Ovariectomy leads to increased insulin resistance in human apolipoprotein B transgenic mice lacking brown adipose tissue.
We studied the role of estrogen in the gender differences in insulin resistance observed in the apoB/BATless mouse, a model of obesity, insulin resistance, and hyperlipidemia. Ovariectomized apoB/BATless mice were more obese and more insulin-resistant than sham ovariectomized apoB/BATless mice. Estrogen replacement by subcutaneous pellet reversed the obesity, lowered plasma insulin levels, and normalized both glucose tolerance and insulin sensitivity associated with ovariectomy. The apoB/BATless mouse should be a good model to delineate the molecular mechanisms whereby estrogen protects against insulin resistance.
Siri
Patty W
PW
Institute of Human Nutrition and Division of Preventive Medicine and Nutrition, Columbia University, New York, NY 10032, USA.
Ginsberg
Henry N
HN
D002001:Adipose Tissue, Brown / Q000473:pathology*; D000818:Animals; D001055:Apolipoproteins B / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D004343:Drug Implants; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000008:administration & dosage; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D051379:Mice; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D009765:Obesity / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D010052:Ovariectomy
D001055:Apolipoproteins B; D001786:Blood Glucose; D004343:Drug Implants; D004967:Estrogens; D007328:Insulin; D004958:Estradiol