Extracellular glutamate decrease in accumbens following cued food delivery.
This study examined the effects of cued vs non-cued food delivery/consumption on extracellular glutamate and dopamine in the nucleus accumbens of food-deprived rats. Animals that always received a food pellet following a series of auditory tones showed a significant decrease in extracellular glutamate following food consumption, whereas animals that had not been previously exposed to tone-food pairing did not (p<0.05). In contrast, extracellular dopamine was significantly increased in the nucleus accumbens during the first time period after food consumption (p<0.05) regardless of whether animals had been exposed to prior tone-food pairing. Results suggest that food delivery/consumption is associated with a decrease in accumbal glutamate if food delivery has been previously paired with predictive environmental cues.
Chapman
Mary Ann
MA
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Cellular and Clinical Neurobiology and Substance Abuse Division, USA.
Roll
John M
JM
Park
Samuel
S
Galloway
Matthew P
MP
D000161:Acoustic Stimulation; D000818:Animals; D003463:Cues; D004435:Eating / Q000502:physiology*; D005110:Extracellular Space / Q000378:metabolism*; D005508:Food Deprivation / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D018698:Glutamic Acid