title: The ileo neorectal anastomosis: an experimental study on development of the surgical technique and theoretical background.
abstract: OBJECTIVE
  The keystones of surgical treatment of ulcerative colitis and familial adenomatous polyposis are resection of the diseased colon with either an ileostomy or restoration of oro-anal continuity with an ileo-anal pouch. The ileo pouch anal anastomosis however, has a 15-35% pouch-related complication rate, 10% failure rate and is accompanied by an unpredictable functional outcome. In order to reduce these unfavourable rates and to improve functional results an alternative surgical technique, the ileo neorectal anastomosis (INRA), was developed experimentally.
  
  
  METHODS
  In an experimental study 12 Yorkshire-Dutch landpigs had a subtotal colectomy and rectal mucosectomy. Subsequently a vascularized ileal mucosa sling was created and transposed on to the denuded rectal muscular cuff in eight. In another four animals a non-vascularized mucosa sling was transposed. The covering ileostomy was closed after 3 weeks. Repeated endoscopies, histological examinations of mucosal biopsies and rectal compliance measurements were carried out to evaluate the functional result of the neorectum.
  
  
  RESULTS
  The surgical procedure of the INRA was technically successful in this animal study. Repeated endoscopy and histology showed complete ileal mucosa ingrowth in the neorectum without severe fibrosis in the group of animals with a vascularized sling. At follow up after 1 year no colonic metaplasia had occurred. Measurements of the neorectal reservoirs in the group of animals with a vascularized INRA procedure showed a median 'maximum tolerated volume' of 338 ml (range 300-410 ml).
  
  
  CONCLUSIONS
  The INRA is technically feasible and reproducible. The histologically proven survival of the vascularized ileal mucosa and development of a compliant neorectal reservoir make the INRA an interesting alternative restorative procedure. Avoidance of the pouch-related complications of the ileo pouch anal anastomosis by this procedure might herald a new era of restorative surgery.
authors.affiliation: Department of Surgery, University Medical Centre Utrecht, The Netherlands. CJHLaarh@elisabeth.nl
authors.forename: C J
authors.initials: CJ
authors.lastname: van Laarhoven
authors.forename: G I
authors.initials: GI
authors.lastname: Andriesse
authors.forename: W A
authors.initials: WA
authors.lastname: Back
authors.forename: M E
authors.initials: ME
authors.lastname: Schipper
authors.forename: L M
authors.initials: LM
authors.lastname: Akkermans
authors.forename: T J
authors.initials: TJ
authors.lastname: van Vroonhoven
authors.forename: H G
authors.initials: HG
authors.lastname: Gooszen