title: Confidence intervals for the 50 per cent response dose.
abstract: Confidence intervals for the 50 per cent response dose are usually computed using either the Delta method or Fieller's procedure. Recently, confidence intervals computed by inverting the asymptotic likelihood ratio test have also been recommended. There is some controversy as to which of these methods should be used. By means of an extensive simulation study we examine these methods as well as confidence intervals obtained by the approximate bootstrap confidence (ABC) procedure and an adjusted form of the likelihood ratio based confidence intervals.
authors.affiliation: Department of Statistics, University of Haifa, Haifa, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Faraggi
authors.forename: P
authors.initials: P
authors.lastname: Izikson
authors.forename: B
authors.initials: B
authors.lastname: Reiser
mesh_terms: D000818:Animals; D003198:Computer Simulation; D016001:Confidence Intervals; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007306:Insecticides; D016013:Likelihood Functions; D013712:Tenebrio / Q000254:growth & development
chemical_list: D007306:Insecticides