[Central nervous system lymphomatoid granulomatosis].
Lymphomatoid granulomatosis (LYG) is a rare multiple organs disease with characteristic angiocentric lymphoproliferative features, most frequently involving the lung, skin, and rarely central nervous system. Most of the systemic LYG were shown as Epstein-Barr virus-associated, T-cell-rich, B-cell proliferative disorder. Based on radiological and pathological characteristics, we analyzed LYG-suspected four cases. The MRI features of LYG showed multiple punctate or linear enhancements that reside along the perivascular space. Pathologically, some cases showed borderline malignancy different from malignant lymphoma. LYG will be determined more clearly by the gene rearrangement studies in addition to radiological and immunohistochemical verifications, which will serve as indications for detection of monoclonality, further prognosis and therapy.
Ogata
Akihiko
A
Department of Neurology, Hokkaido University Graduate School of Medicine.
D002493:Central Nervous System Diseases / Q000473:pathology*; D006801:Humans; D008230:Lymphomatoid Granulomatosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged