title: Adult type granulosa cell tumor causing precocious pseudopuberty in a 6 year-old girl.
abstract: Malignant ovarian tumors are responsible for 2-3% of all cases of precocious pseudopuberty (PP) in girls. The most common forms of ovarian tumors presenting as PP are the granulosa cell tumors (GCT). The clinical and pathological features of granulosa cell tumors that occur frequently in young girls, so-called juvenile granulosa cell tumors (JGCT), differ histologically from those occurring in adults. As a cause of PP in young girls, adult type granulosa cell tumors (AGCT) are extremely rare. We report a 6 year-old girl presenting with early breast development and vaginal bleeding due to a well encapsulated ovarian tumor. Microscopic features of the resected tumor were characteristic of AGCT.
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, SSK Goztepe Educational Hospital, Istanbul, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Isguven
authors.forename: Asim
authors.initials: A
authors.lastname: Yoruk
authors.forename: Erdal
authors.initials: E
authors.lastname: Adal
authors.forename: Ilknur
authors.initials: I
authors.lastname: Arslanoglu
authors.forename: Sennur
authors.initials: S
authors.lastname: Ilvan
authors.forename: Metin
authors.initials: M
authors.lastname: Yildiz
mesh_terms: D001202:Ascitic Fluid / Q000473:pathology; D002648:Child; D005260:Female; D006106:Granulosa Cell Tumor / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D011629:Puberty, Precocious / Q000209:etiology*