Improved biotransformations on charged PEGA supports.
PEGA supports functionalised with permanent charges show superior swelling properties in aqueous media when compared to neutral PEGA; a novel positively charged PEGA resin significantly improves penicillin G amidase (PGA) catalysed biotransformation on solid support, by favouring accessibility of the negatively charged enzyme.
Basso
Alessandra
A
Dipartimento di Scienze Farmaceutiche, Università degli Studi, Piazzale Europa 1, 34127, Trieste, Italy.
De Martin
Luigi
L
Gardossi
Lucia
L
Margetts
Graham
G
Brazendale
Ian
I
Bosma
Annie Y
AY
Ulijn
Rein V
RV
Flitsch
Sabine L
SL
D001711:Biotransformation; D011092:Polyethylene Glycols / Q000737:chemistry*
C109511:bis(polyoxyethylene bis(amine)); D011092:Polyethylene Glycols