title: A patient with Takayasu's arteritis treated with corticosteroids who developed primary biliary cirrhosis.
abstract: A 40-year-old woman with a history of fever and arthralgia since age 17 had received long-term prednisolone (PSL) therapy. She was diagnosed with Takayasu's arteritis in 1980 and given PSL. The symptoms were well controlled until she developed itching in 1998. Laboratory tests showed elevated levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyltranspeptidase, total cholesterol, and immunoglobulin M (IgM). She tested positive for anti-mitochondria antibody and for both IgG and IgM anti-pyruvate dehydrogenases. Liver biopsy findings were typical of primary biliary cirrhosis (PBC). Our patient's clinical course suggested that an adequate amount of PSL to control Takayasu's arteritis does not necessarily prevent the development of PBC.
authors.affiliation: Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ito
authors.forename: Shogo
authors.initials: S
authors.lastname: Ohkoshi
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Aoyagi
authors.forename: Kenta
authors.initials: K
authors.lastname: Suzuki
authors.forename: Tohru
authors.initials: T
authors.lastname: Takahashi
authors.forename: Minoru
authors.initials: M
authors.lastname: Nomoto
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakano
authors.forename: Masaaki
authors.initials: M
authors.lastname: Arakawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Asakura
authors.forename: Fumitake
authors.initials: F
authors.lastname: Gejyo
mesh_terms: D000328:Adult; D000792:Angiography; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000517:prevention & control; D011239:Prednisolone / Q000627:therapeutic use*; D013625:Takayasu Arteritis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone