title: No acute effect of red wine on the coagulation pathway in healthy men.
abstract: Binge drinking is associated with an increased risk of cardiovascular events. Those events often happen within hours after alcohol is consumed. Apart from arrhythmias and changes in blood pressure, these events may be caused by an acute (i.e., occurring within a 24-h period) shift of the hemostatic balance in a thrombogenic direction. Alcohol can influence platelet aggregation and inhibit fibrinolysis, but little is known about its direct effect on coagulation. In the current study, parameters of coagulation, reflecting either stimulation or inhibition, were measured 5 and 15 h after the consumption of four (62.5 g of alcohol) and eight (125 g of alcohol) glasses of red wine. Both doses had no direct effect on activated cephalin time, thrombin-antithrombin complexes, factors VII and VIII, and von Willebrand factor. In contrast with the observed effects on thrombocytes and fibrinolysis, the consumption of large amounts of wine does not influence the coagulation pathway.
authors.affiliation: Department of Internal Medicine, Meander Medical Center, P.O. Box 1502, 3800 BM Amersfoort, The Netherlands.
authors.forename: Pierre M
authors.initials: PM
authors.lastname: van Golde
authors.forename: Rob J
authors.initials: RJ
authors.lastname: Kraaijenhagen
authors.forename: Bonno N
authors.initials: BN
authors.lastname: Bouma
authors.forename: Albert
authors.initials: A
authors.lastname: van de Wiel
mesh_terms: D000328:Adult; D000991:Antithrombins / Q000378:metabolism; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D014920:Wine
chemical_list: D000991:Antithrombins; D001779:Blood Coagulation Factors; D008055:Lipids; D007770:L-Lactate Dehydrogenase