Scopolamine impairs human recognition memory: data and modeling.
Eight subjects studied a set of complex visual images after administration of 0.4 mg scopolamine. Another 8 subjects performed the same task without drug administration. On a subsequent item recognition test, subjects rated, on a 5-point scale, their confidence that the studied pictures and an equal number of unstudied lures were actually presented. Results showed that scopolamine affected responses to studied items, but not unstudied lures, demonstrating an unambiguous effect of scopolamine on recognition memory. To describe the scopolamine-injected subjects' data, the authors constructed a new model of 2-process recognition that includes the A. P. Yonelinas (1994) model as a limiting case. The model analysis suggests that scopolamine affected both familiarity and recollection. In particular, scopolamine did not affect the frequency with which recollection took place, but rather, affected the amount of recollected information.
Sherman
Seth J
SJ
Department of Psychology, Boston University, 2 Cummington Street, Boston, Massachusetts 02215, USA.
Atri
Alireza
A
Hasselmo
Michael E
ME
Stern
Chantal E
CE
Howard
Marc W
MW
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000523:psychology; D008960:Models, Psychological; D010775:Photic Stimulation / Q000379:methods; D021641:Recognition, Psychology / Q000187:drug effects* / Q000502:physiology; D012601:Scopolamine / Q000009:adverse effects / Q000494:pharmacology*; D013223:Statistics as Topic
D012601:Scopolamine