title: Inheritance of cleft palate in South America: evidence for a major locus recessive.
abstract: OBJECTIVE
  Determine the model of inheritance of non-syndromic cleft palate in humans.
  
  
  METHODS
  Complex segregation analysis performed in families of consecutive newborns affected with non-syndromic cleft palate.
  
  
  METHODS
  The Latin American Collaborative Study of Congenital Malformations (ECLAMC). Four hundred and seven consecutive newborns affected with non-syndromic cleft palate registered during the period 1967-97.
  
  
  METHODS
  Likelihood ratio test and Akaike information criterion (AIC) values.
  
  
  RESULTS
  The single major locus recessive model provided a significantly better explanation of the data. It was the most parsimonious and had the smallest AIC value of the six models tested with approximately the same likelihood as the general model (chi2 = 2.44, p = 0.5).
  
  
  CONCLUSIONS
  To have defined a genetic model for non-syndromic cleft palate and provided evidence for a single major locus inheritance suggests that genetic linkage studies could be implemented.
authors.affiliation: Latin American Collaborative Study of Congenital Malformations (ECLAMC), Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. alexandre-vieira@uiowa.edu
authors.forename: A R
authors.initials: AR
authors.lastname: Vieira
authors.forename: P A
authors.initials: PA
authors.lastname: Romitti
authors.forename: I M
authors.initials: IM
authors.lastname: Orioli
authors.forename: E E
authors.initials: EE
authors.lastname: Castilla
mesh_terms: D002972:Cleft Palate / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D007231:Infant, Newborn; D040582:Inheritance Patterns; D016013:Likelihood Functions; D016015:Logistic Models; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D013020:South America / Q000453:epidemiology