Relation between phenotype of tumor cells and clinicopathology in bovine leukosis.
Thirty-three cases of enzootic bovine leukosis (EBL) and 14 cases of sporadic bovine leukosis (SBL) were examined by immunohistochemistry using 6 monoclonal antibodies against leukocyte differentiation molecules of bovine leukocytes. There were 17 cases of B-1a cell type, 10 cases of B-1b cell type and 6 cases of B-2 cell type in EBL, and 5 cases originating from B cells (B-2 cell type) and 9 cases originating from immature T cells in SBL. The average age for the EBL cases of B-1a cell type was 8.6 years, B-1b cell type was 6.5 years, and of B-2 cell type was 4.5 years. In cases of SBL, immature T cell type patients were younger than B-2 cell type ones. The lymphoma originating from B cells differed from that originating from T cells in morphology. In T cell tumors, the nucleus of tumor cells was round, the edge of the cytoplasm obvious, and tumor cells were sporadically present and proliferated. When compared with T cells, the region among B cells was obscure. But, there was no relation between phenotype and the histologic classification of tumor cells. In EBL, beyond the lymph node, tumors of B-1a and B-1b types had developed in the heart and abomasum, and those of the B-2 type tended to occur in liver. In SBL, B-2 type and T type cells formed tumors in the liver, kidney, thymus, and one case of T-cell type tumor formed on the skin. We would like to propose a new classification of bovine leukosis as EBL, calf type B-cell lymphoma, juvenile T-cell lymphoma and skin type T-cell lymphoma.
Yin
Shan-Ai
SA
United Graduate School of Veterinary Sciences, Gifu University, Japan.
Makara
Manami
M
Pan
Yaoqian
Y
Ishiguro
Hiroyuki
H
Ikeda
Manabu
M
Numakunai
Shigeru
S
Goryo
Masanobu
M
Okada
Kosuke
K
D000018:Abomasum / Q000473:pathology; D000375:Aging; D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000473:pathology; D002417:Cattle; D004067:Digestive System Neoplasms / Q000473:pathology / Q000662:veterinary; D016583:Enzootic Bovine Leukosis / Q000473:pathology*; D005260:Female; D006338:Heart Neoplasms / Q000473:pathology / Q000662:veterinary; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology / Q000662:veterinary; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000473:pathology / Q000662:veterinary; D008297:Male; D009206:Myocardium / Q000473:pathology; D010641:Phenotype; D013601:T-Lymphocytes / Q000473:pathology; D014407:Tumor Cells, Cultured
D000954:Antigens, Surface