title: Is the antidepressive effect of sleep deprivation stabilized by a three day phase advance of the sleep period? A pilot study.
abstract: Sleep deprivation (SD) induces a rapid amelioration of mood in about 60 % of depressed patients. After the next night of sleep, however, most patients experience a relapse. Previous studies demonstrated that a six day sleep-phase advance protocol prevents relapses in about 60 % of patients who responded positively to SD. We investigated whether also a three day phase advance of the sleep period might be able to maintain the antidepressant effects of SD. Twenty-eight medicated depressed inpatients, who had a significant improvement after a SD in one night were recruited for this study. The phase advance protocol began on the first day after SD with a bed time from 5:00 p. m. to 12:00 p. m. on the first, from 7:00 p. m. to 2:00 a. m. on the second and 9:00 p. m. to 4:00 a. m. on the third day after SD. Three patients dropped out because of protocol violations. Only ten of the remaining 25 SD responders had a relapse during the three days of phase advance treatment or during the two days after it. Two of the relapsers improved again until day 6, i. e. 68 % showed an improvement of at least 30 % six days after the beginning of the treatment. This study indicates that even a three day phase advance protocol may help to prevent relapses after successful SD.
authors.affiliation: Department of Psychiatry and Psychotherapy, Klinikum of the Albert-Ludwigs-University, Hauptstrasse 5, 79104 Freiburg, Germany. Ulrich_Voderholzer@psyallg.ukl.uni-freiburg.de
authors.forename: U
authors.initials: U
authors.lastname: Voderholzer
authors.forename: G
authors.initials: G
authors.lastname: Valerius
authors.forename: L
authors.initials: L
authors.lastname: Schaerer
authors.forename: D
authors.initials: D
authors.lastname: Riemann
authors.forename: H
authors.initials: H
authors.lastname: Giedke
authors.forename: F
authors.initials: F
authors.lastname: Schwärzler
authors.forename: M
authors.initials: M
authors.lastname: Berger
authors.forename: M
authors.initials: M
authors.lastname: Wiegand
mesh_terms: D002940:Circadian Rhythm; D003865:Major Depressive Disorder / Q000517:prevention & control / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D055502:Secondary Prevention; D012890:Sleep; D012892:Sleep Deprivation / Q000523:psychology*; D016896:Treatment Outcome