The origin and maintenance of virulence for the human pathogenic fungus Cryptococcus neoformans.
The origin of virulence in environmental fungi that have no requirement for animal hosts in their life cycle is enigmatic. Cryptococcus neoformans is a human pathogenic fungus with virulence factors for mammalian pathogenesis that also contribute to environmental survival. C. neoformans virulence may originate from selection pressures imposed by environmental predators.
Steenbergen
Judith N
JN
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Casadevall
Arturo
A
D003453:Cryptococcosis / Q000276:immunology / Q000382:microbiology*; D003455:Cryptococcus neoformans / Q000201:enzymology / Q000235:genetics / Q000472:pathogenicity*; D019143:Evolution, Molecular; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D008264:Macrophages / Q000382:microbiology; D014774:Virulence; D037521:Virulence Factors / Q000378:metabolism
D037521:Virulence Factors