Recent advances on the role of CD40 and dendritic cells in immunity and tolerance.
CD40 is a key signaling pathway for the function of B cells, monocytes, and dendritic cells in the immune system, and plays an important role in inflammatory pathways of nonhemopoietic cells. The NFkappaB family of transcription factors is a critical mediator in inflammation. NFkappaB is involved both in the regulation of CD40 expression and in cell signaling after CD40 ligation. This positive feedback loop linking NFkappaB and CD40 plays an important role in the control of the adaptive immune response, with fundamental implications for immunity and tolerance in vivo.
O'Sullivan
Brendan
B
Center for Immunology and Cancer Research, Pricess Alexandra Hospital, University of Queensland, Queensland, Australia.
Thomas
Ranjeny
R
D019013:CD40 Antigens / Q000276:immunology* / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology*; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000166:cytology; D007108:Immune Tolerance; D015398:Signal Transduction / Q000276:immunology
D019013:CD40 Antigens