Inhibition of DNA synthesis by carvacrol in mouse myoblast cells bearing a human N-RAS oncogene.
Monoterpenes are dietary components found in the essential oils of a wide variety of plants. A number of these monoterpenes have antitumor activity. We have investigated the effects of carvacrol obtained by fractional distillation of Origanum onites L. essential oil, on DNA synthesis of N-ras transformed myoblast cells, CO25. Incubation of the cells with different doses of carvacrol prevented DNA synthesis in the growth medium and ras-activating medium, which contains dexamethasone. This result demonstrates that carvacrol inhibits growth of myoblast cells even after activation of mutated N-ras oncogene, suggesting the possibility that carvacrol may find application in cancer therapy.
Zeytinoglu
H
H
Department of Biology, Faculty of Sciences, Anadolu University, Eskisehir, Turkey. hzeytino@anadolu.edu.tr
Incesu
Z
Z
Baser
K H C
KH
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002461:Cell Line, Transformed; D000081007:Cymenes; D004305:Dose-Response Relationship, Drug; D011905:Genes, ras; D006801:Humans; D051379:Mice; D039821:Monoterpenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D032446:Myoblasts / Q000187:drug effects; D019384:Nucleic Acid Synthesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D031341:Origanum; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D000081007:Cymenes; D039821:Monoterpenes; D019384:Nucleic Acid Synthesis Inhibitors; D010938:Plant Oils; C073316:carvacrol