title: Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria.
abstract: The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.
authors.affiliation: Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, ul. Pawinskiego 5A, 02-106 Warsaw, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Piwowarski
authors.forename: Pawel
authors.initials: P
authors.lastname: Grzechnik
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dziembowski
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Dmochowska
authors.forename: Michal
authors.initials: M
authors.lastname: Minczuk
authors.forename: Piotr P
authors.initials: PP
authors.lastname: Stepien
mesh_terms: D003001:Cloning, Molecular; D003593:Cytoplasm / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics; D006367:HeLa Cells; D006801:Humans; D008856:Microscopy, Fluorescence; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism; D011117:Polyribonucleotide Nucleotidyltransferase / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D010446:Peptide Fragments; D011994:Recombinant Proteins; D011117:Polyribonucleotide Nucleotidyltransferase