title: Isolation of peridinin-related norcarotenoids with cell growth-inhibitory activity from the cultured dinoflagellate of Symbiodinium sp., a symbiont of the Okinawan soft coral Clavularia viridis, and analysis of fatty acids of the dinoflagellate.
abstract: Two norcarotenoids, 1 and 2, related to peridinin (3) were isolated from the cultured dinoflagellate of the genus Symbiodinium, a symbiont of the Okinawan soft coral Clavularia viridis, which contains in abundance antitumor marine prostanoids such as clavulones. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. These compounds showed significant growth-inhibitory activity in vitro toward cancer cells. Analysis of fatty acids of the dinoflagellate was also carried out, suggesting that the marine prostanoids are produced by the host soft coral itself.
authors.affiliation: School of Life Science, Tokyo University of Pharmacy and Life Science, Tokyo, Japan.
authors.forename: Motoya
authors.initials: M
authors.lastname: Suzuki
authors.forename: Kinzo
authors.initials: K
authors.lastname: Watanabe
authors.forename: Shoko
authors.initials: S
authors.lastname: Fujiwara
authors.forename: Toshie
authors.initials: T
authors.lastname: Kurasawa
authors.forename: Takako
authors.initials: T
authors.lastname: Wakabayashi
authors.forename: Mikio
authors.initials: M
authors.lastname: Tsuzuki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Iguchi
authors.forename: Takao
authors.initials: T
authors.lastname: Yamori
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry* / Q000469:parasitology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002338:Carotenoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D004141:Dinoflagellida / Q000737:chemistry*; D056890:Eukaryota / Q000737:chemistry; D005227:Fatty Acids / Q000032:analysis*; D006790:Host-Parasite Interactions; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D013559:Symbiosis
chemical_list: D000970:Antineoplastic Agents; D005227:Fatty Acids; C016040:peridinin; D002338:Carotenoids