Tolerance: of mice and men.
Little is known about the effect of an individual's immune history on his or her response to an allogeneic tissue transplant. An important study now reveals that individuals harboring virally-induced memory T cells that are cross reactive with donor alloantigen are resistant to conventional strategies designed to induce transplant tolerance.
Sachs
David H
DH
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA. sachs@helix.mgh.harvard.edu
D000818:Animals; D000941:Antigens; D003429:Cross Reactions; D006801:Humans; D007108:Immune Tolerance; D007156:Immunologic Memory; D051379:Mice; D011323:Primates; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000941:Antigens