title: Phylogenetic analysis of CSP and MSP-9 gene sequences demonstrates the close relationship of Plasmodium coatneyi to Plasmodium knowlesi.
abstract: Plasmodium coatneyi is a simian malaria parasite with various biological features similar to the human malaria P. falciparum and potential as a model for severe cases of malaria. We have characterized two single-copy genes from P. coatneyi, the circumsporozoite protein and merozoite surface protein-9 genes, and determined its phylogenetic relationship among Plasmodium species. This study demonstrates that while it has similarities to P. falciparum, P. coatneyi belongs to a distant clade including several simian malaria parasites and the human malaria P. vivax. P. coatneyi forms a monophyletic group with P. knowlesi, demonstrating their close relationship despite some very distinctive biological characteristics.
authors.affiliation: Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, N.E., Atlanta, GA 30329, USA.
authors.forename: Esmeralda
authors.initials: E
authors.lastname: Vargas-Serrato
authors.forename: Vladimir
authors.initials: V
authors.lastname: Corredor
authors.forename: Mary R
authors.initials: MR
authors.lastname: Galinski
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D017125:Genes, Protozoan; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D010961:Plasmodium / Q000235:genetics*; D010963:Plasmodium falciparum / Q000235:genetics; D016790:Plasmodium knowlesi / Q000235:genetics*; D010966:Plasmodium vivax / Q000235:genetics; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013045:Species Specificity
chemical_list: D008565:Membrane Proteins; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan; C455300:merozoite surface protein 9, Plasmodium