Diterpenoid and phenolic glycosides from the roots of Rhododendron molle.
Two new grayanane diterpenoid glucosides, rhodomosides A (1), B (2) and two new phenolic glycosides 3, 4 together with a known glucosyringic acid (5) were isolated from the roots of Rhododendron molle G. Don (Ericaceae). Their structures were elucidated on the basis of spectral analysis. Compounds 3, 4 and 5 were found to inhibit the proliferation of murine B lymphocytes in vitro, while compound 3 also showed stimulatory activity on the proliferation of murine T lymphocytes in vitro.
Bao
Guan-Hu
GH
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China.
Wang
Li-Quan
LQ
Cheng
Kin-Fai
KF
Feng
Yong-Hong
YH
Li
Xiao-Yu
XY
Qin
Guo-Wei
GW
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D016572:Cyclosporine / Q000494:pharmacology; D004224:Diterpenes / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D029793:Rhododendron; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000187:drug effects*
D004224:Diterpenes; D006027:Glycosides; D007166:Immunosuppressive Agents; D010936:Plant Extracts; D016572:Cyclosporine