title: Pathological subgroups may predict complications but not late failure after ileal pouch-anal anastomosis for indeterminate colitis.
abstract: BACKGROUND
  Ileal pouch-anal anastomosis (IPAA) for indeterminate colitis (IndC) may lead to an increased risk of perineal complications and pouch loss. This study evaluated pathological subgroups of IndC to identify a predictor of increased complication rates after IPAA for IndC.
  
  
  METHODS
  Of 171 IPAAs with a postoperative diagnosis of IndC, IndC was confirmed in 115 of the 140 specimens available for re-examination. These were divided into IndC favouring ulcerative colitis (Group I; n = 99), 'true' IndC (Group II; n = 8), and IndC favouring Crohn's (Group III; n = 8). 61 presented with fulminant colitis. Patients in Group I were subdivided into having (A) deep ulcers (B) transmural lymphoid aggregates (C) skip lesions (D) terminal ileal inflammation and/or (E) a caecal patch. Outcome was determined by chart analysis, and compared to 231 randomly selected patients with IPAA for ulcerative colitis (UC) matched for age, gender, and follow-up.
  
  
  RESULTS
  Only patients with evidence of deep ulceration (Group IA) had a significant increase in the incidence of Crohn's disease (4.3%vs. 0.43%, P = 0.04), complex perianal fistulae (4.3%vs. 0.43%, P = 0.04), and pelvic abscess (12.9%vs. 2.2%, P < 0.001). No pathological subgroup of IndC patients had a significantly different rate of pouch failure or pouch loss.
  
  
  CONCLUSIONS
  Pathological stratification may predict those more likely to develop Crohn's disease or other complications, but not pouch failure. On this basis, we feel that patients with IndC should not be precluded from having IPAA surgery.
authors.affiliation: Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
authors.forename: T
authors.initials: T
authors.lastname: Gramlich
authors.forename: C P
authors.initials: CP
authors.lastname: Delaney
authors.forename: A C
authors.initials: AC
authors.lastname: Lynch
authors.forename: F H
authors.initials: FH
authors.lastname: Remzi
authors.forename: V W
authors.initials: VW
authors.lastname: Fazio
mesh_terms: D000714:Anastomosis, Surgical; D003092:Colitis / Q000473:pathology* / Q000601:surgery*; D039021:Colonic Pouches / Q000009:adverse effects; D003424:Crohn Disease / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D017211:Treatment Failure