Airway wall remodeling: friend or foe?
Airway wall remodeling is well documented for asthmatic airways and is believed to result from chronic and/or short-term exposure to inflammatory stimuli. Airway wall remodeling can contribute to airway narrowing as well as to the airway hyperresponsiveness, which is a characteristic abnormality in asthma. However, the potential for airway narrowing could be much worse if it were not for some of the protective effects of remodeling that may help to limit airway narrowing in asthmatic patients. This minireview discusses the evidence for airway wall remodeling and its effects, friend and/or foe, on airway narrowing in asthmatic patients.
McParland
Brent E
BE
McDonald Research Laboratory/The iCAPTURE Center, St Paul's Hospital, University of British Columbia, Vancouver, Canada V6Z 1Y6.
Macklem
Peter T
PT
Pare
Peter D
PD
D000403:Airway Resistance / Q000502:physiology; D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D001980:Bronchi / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D004548:Elasticity; D004848:Epithelium / Q000503:physiopathology; D006801:Humans; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000033:anatomy & histology / Q000502:physiology