Platelet-activating factor and normal or leukaemic haematopoiesis.
Platelet-activating factor (PAF), a phospholipid mediator with a wide range of actions on mature leukocytes, acts directly during early human haematopoiesis by affecting the growth of haematopoietic progenitors and indirectly, by modulating cytokine synthesis by bone marrow stromal cells. At this time, its role during leukaemic diseases remains speculative. The lack of membrane PAF receptor (PAF-R) on leukaemic blasts suggest that this receptor represents a marker of mature cells and its membrane induction a consequence of cell maturation. While the couple PAF/PAF-R has been largely studied using B cell lines, few results are available using B cells of patients with haematopoietic malignancies casting some doubts concerning the potential role (if any) of this molecule during leukaemic diseases.
Denizot
Yves
Y
UMR CNRS 6101, Faculté de Médecine, 2 rue Dr Marcland, 87025, Limoges, France. yves.denizot@unilim.fr
Guglielmi
Laurence
L
Donnard
Magali
M
Trimoreau
Franck
F
D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D006410:Hematopoiesis; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D010972:Platelet Activating Factor / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled; D015398:Signal Transduction
D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C039351:platelet activating factor receptor