Targeting genes and transcription factors to segregated nuclear compartments.
With increasingly detailed images of nuclear structures revealed by advanced microscopy, a remarkably compartmentalized cell nucleus has come into focus. Although this complex nuclear organization remains largely unexplored, some progress has been made in deciphering the functional aspects of various subnuclear structures, revealing how this elaborate framework can influence gene activation. Several recent studies have helped illustrate how cells might utilize the nuclear architecture as an additional level of transcriptional control, perhaps by targeting genes and regulatory factors to specific sites within the nucleus that are designated for active RNA synthesis.
Isogai
Yoh
Y
Department of Molecular and Cellular Biology, University of California, Berkeley and Howard Hughes Medical Institute, 401 Barker Hall, Berkeley, CA 94720-3204, USA.
Tjian
Robert
R
D000818:Animals; D022003:Cell Nucleus Structures / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology*; D006801:Humans; D021381:Protein Transport / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
D014157:Transcription Factors