Fundamental structure-activity relationships associated with a new structural class of respiratory syncytial virus inhibitor.
Structure-activity relationships surrounding the dialkylamino side chain of a series of benzotriazole-derived inhibitors of respiratory syncytial virus fusion based on the screening lead 1a were examined. The results indicate that the topology of the side chain is important but the terminus element offers considerable latitude to modulate physical properties.
Yu
Kuo Long
KL
Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5, Research Parkway, 06492, Wallingford, CT, USA.
Zhang
Yi
Y
Civiello
Rita L
RL
Kadow
Kathleen F
KF
Cianci
Christopher
C
Krystal
Mark
M
Meanwell
Nicholas A
NA
D000478:Alkylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D007202:Indicators and Reagents; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry; D012136:Respiratory Syncytial Viruses / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001562:Benzimidazoles; D007202:Indicators and Reagents; D007659:Ketones; D014230:Triazoles; C012771:benzotriazole