Simulation of pore formation in lipid bilayers by mechanical stress and electric fields.
We describe computer simulations of pore formation and membrane rupture of phospholipid bilayers under mechanical and electrical stress. On the nanosecond simulation time scale, pores are induced by a lateral pressure exceeding -200 bar or by an applied electric field of 0.5 V/nm.
Tieleman
D Peter
DP
Department of Biological Sciences, University of Calgary, Alberta, Canada T2N 1N4. tielman@ucalgary.ca
Leontiadou
Hari
H
Mark
Alan E
AE
Marrink
Siewert-Jan
SJ
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry*; D004574:Electromagnetic Fields; D008051:Lipid Bilayers / Q000737:chemistry*; D008566:Membranes / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry*; D013314:Stress, Mechanical
D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D015060:1,2-Dipalmitoylphosphatidylcholine; C017251:1,2-oleoylphosphatidylcholine