title: Comparison of lipid and non-lipid markers of atherosclerosis in arterial versus venous blood.
abstract: BACKGROUND
  Early studies have suggested that there may be differences in the concentration of lipoprotein particles and their associated apolipoproteins in arterial and venous blood and that this gradient might explain a proclivity to develop atherosclerotic lesions. The aim of this study was to use current methods of analysis to determine levels of these components, including particle densities and several common inflammatory markers in arterial and venous blood.
  
  
  METHODS
  Samples of arterial and venous blood were obtained nearly simultaneously in 26 patients undergoing right and left heart catheterization. Analyses were performed using enzymatic, immunoturbidimetric and ultracentrifugation assays.
  
  
  RESULTS
  Data obtained for total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, HDL and LDL particle density, high sensitivity C-reactive protein, serum amyloid-A and apoprotein B-100 concentrations in arterial and venous blood did not demonstrate any significant difference in the means.
  
  
  CONCLUSIONS
  Arterial and venous blood can be used interchangeably to study the effect of blood concentrations of common soluble surrogate markers of atherosclerosis.
authors.affiliation: Cardiac and Vascular Institute, Scott and White Memorial Hospital and Clinic, Scott, Sherwood and Brindley Foundation, The Texas A&M University System Health Science Center, College of Medicine, Temple, TX 76508, USA.
authors.forename: Bruce
authors.initials: B
authors.lastname: Palmer
authors.forename: Linley E
authors.initials: LE
authors.lastname: Watson
authors.forename: Mark W
authors.initials: MW
authors.lastname: Riggs
authors.forename: Mark
authors.initials: M
authors.lastname: Lawrence
authors.forename: Clinton E
authors.initials: CE
authors.lastname: Baisden
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: McNeal
authors.forename: Ronald D
authors.initials: RD
authors.lastname: Macfarlane
mesh_terms: D000682:Amyloid / Q000097:blood; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D001158:Arteries; D001161:Arteriosclerosis / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014680:Veins
chemical_list: D000682:Amyloid; D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D015415:Biomarkers; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol