title: Novel inhibitors of procollagen C-terminal proteinase. Part 1: diamino Acid hydroxamates.
abstract: The parallel synthesis of novel inhibitors of procollagen C-terminal proteinase is described. The synthetic strategy allowed for the facile synthesis of a large number of side-chain diversified diamino acid hydroxamates, of which the D-diaminopropionic acid derivatives were shown to be single digit nanomolar PCP inhibitors.
authors.affiliation: CombiChem Inc., 4570 Executive Drive, 92121, San Diego, CA, USA. ndelaet@kemia.com
authors.forename: N G J
authors.initials: NG
authors.lastname: Delaet
authors.forename: L A
authors.initials: LA
authors.lastname: Robinson
authors.forename: D M
authors.initials: DM
authors.lastname: Wilson
authors.forename: R W
authors.initials: RW
authors.lastname: Sullivan
authors.forename: E K
authors.initials: EK
authors.lastname: Bradley
authors.forename: S M
authors.initials: SM
authors.lastname: Dankwardt
authors.forename: R L
authors.initials: RL
authors.lastname: Martin
authors.forename: H E
authors.initials: HE
authors.lastname: Van Wart
authors.forename: K A M
authors.initials: KA
authors.lastname: Walker
mesh_terms: D055395:Bone Morphogenetic Protein 1; D019485:Bone Morphogenetic Proteins / Q000037:antagonists & inhibitors*; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007700:Kinetics; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D019485:Bone Morphogenetic Proteins; D006877:Hydroxamic Acids; D007202:Indicators and Reagents; D011480:Protease Inhibitors; D008666:Metalloendopeptidases; D055395:Bone Morphogenetic Protein 1