title: T-cell effector mechanisms: gammadelta and CD1d-restricted subsets.
abstract: Gammadelta T lymphocytes and CD1d-restricted natural killer T cells are classified as innate T lymphocytes, which perform effector functions that protect from malignancy and maintain tissue integrity. Innate T cells also play important regulatory roles in autoimmunity, inflammation and infection. Recent advances have established innate T cells as both effectors and regulators of disease in biological models.
authors.affiliation: The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Jameson
authors.forename: Deborah
authors.initials: D
authors.lastname: Witherden
authors.forename: Wendy L
authors.initials: WL
authors.lastname: Havran
mesh_terms: D000818:Animals; D018949:Antigens, CD1 / Q000032:analysis*; D055610:Antigens, CD1d; D017209:Apoptosis; D001327:Autoimmune Diseases / Q000276:immunology; D006706:Homeostasis; D007239:Infections / Q000276:immunology; D018836:Inflammation Mediators / Q000502:physiology; D007694:Killer Cells, Natural / Q000276:immunology; D009369:Neoplasms / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000145:classification / Q000276:immunology*
chemical_list: D018949:Antigens, CD1; D055610:Antigens, CD1d; D018836:Inflammation Mediators; D016692:Receptors, Antigen, T-Cell, gamma-delta