title: Differential effects of surgical sympathetic block on sudomotor and vasoconstrictor function.
abstract: OBJECTIVE
  To assess the effects of a surgical block of the sympathetic chain at the T2 level on vasoconstriction and palmar sweating in patients with palmar hyperhidrosis.
  
  
  METHODS
  In a prospective study, sympathetic vasoconstriction was measured by laser-Doppler imaging and by computer-assisted infrared thermography (rewarming kinetics following immersion of both hands in ice water [4 degrees C, 30 seconds]) in 61 patients with hyperhidrosis preoperatively and 2 days and 3 months postoperatively. In addition, palmar sweating preoperatively and 3 months postoperatively was assessed by quantitative sudometry.
  
  
  RESULTS
  Before surgery, rewarming kinetics was significantly slower in the patients (n = 61) than in the healthy control subjects (n = 28). Two days after the block, baseline skin temperature increased by about 5 degrees C, and rewarming was massively accelerated in each of the patients. Three months postoperatively, rewarming kinetics was still accelerated in 36 hands, was unchanged from the preoperative condition in 42, and had worsened in 12. These changes were accompanied by parallel alterations of laser-Doppler flux. However, palmar sweating was massively reduced in all but one patient, irrespective of the different rewarming kinetics.
  
  
  CONCLUSIONS
  T2 sympathectomy leads to long-lasting inhibition of palmar sweating, which does not correlate to loss of vasoconstriction. Recurrent and enhanced vasoconstrictor function 3 months following endoscopic sympathetic block has major implications for its use to treat enhanced vasoconstriction.
authors.affiliation: Department of Surgery, University of Erlangen-Nürnberg, Germany.
authors.forename: C H
authors.initials: CH
authors.lastname: Schick
authors.forename: K
authors.initials: K
authors.lastname: Fronek
authors.forename: A
authors.initials: A
authors.lastname: Held
authors.forename: F
authors.initials: F
authors.lastname: Birklein
authors.forename: W
authors.initials: W
authors.lastname: Hohenberger
authors.forename: M
authors.initials: M
authors.lastname: Schmelz
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D006945:Hyperhidrosis / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D007700:Kinetics; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D012008:Recurrence; D012867:Skin / Q000098:blood supply; D013546:Sweating; D013562:Sympathectomy; D013817:Thermography; D014661:Vasoconstriction