title: Lack of upregulation of epidermal fatty acid binding protein in dithranol induced irritation.
abstract: The exact role of epidermal fatty acid binding protein (E-FABP) in skin is unknown. A restoration of the barrier function may be associated with an upregulation of E-FABP. Moreover, E-FABP is upregulated in a variety of cells in response to oxidative stress. A recent observation that dithranol induced irritation is not associated with skin barrier impairment prompted us to investigate the expression of E-FABP in this skin condition to elucidate the unknown function of this protein in skin. This study shows lack of E-FABP upregulation after a single application of dithranol on uninvolved skin of patients with psoriasis. The expression of E-FABP in dithranol irritation correlates with the unimpaired skin barrier function as assessed by measurements of TEWL. Furthermore, we did not find evidence for the recently introduced hypothesis that E-FABP functions as an antioxidant protein in the skin irritation induced by dithranol as oxidative stressor.
authors.affiliation: Department of Dermatology, University Medical Centre Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. mkucharekova@derma.umcn.nl
authors.forename: Martin
authors.initials: M
authors.lastname: Kucharekova
authors.forename: Wynand H P M
authors.initials: WH
authors.lastname: Vissers
authors.forename: Joost J
authors.initials: JJ
authors.lastname: Schalkwijk
authors.forename: Peter C M
authors.initials: PC
authors.lastname: van de Kerkhof
authors.forename: Peter G M
authors.initials: PG
authors.lastname: van der Valk
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000875:Anthralin / Q000008:administration & dosage; D002352:Carrier Proteins / Q000378:metabolism*; D004890:Erythema / Q000139:chemically induced / Q000378:metabolism*; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins; D015854:Up-Regulation; D014870:Water Loss, Insensible
chemical_list: D002352:Carrier Proteins; C493412:FABP5 protein, human; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins; D000875:Anthralin