Evaluation of PARVG located on 22q13 as a candidate tumor suppressor gene for colorectal and breast cancer.
Colorectal cancer (CRC) and breast cancer constitute common neoplasms in Western countries and leading causes of cancer-related death. Development and progression of both malignancies occur as a multistep process, requiring the activation of oncogenes and the inactivation of several tumor suppressor genes. Our group has recently identified a minimal region of deletion on 22q13 involved in CRC and breast cancer patients, which is highly indicative of the existence of a tumor suppressor gene (or genes). We performed mutation analysis of the PARVG gene, one of the genes present on the 22q13 region of interest, which has been previously demonstrated to have a reduced expression in some cancer cell lines. We have identified several DNA variants that are not compatible with pathogenic mutations. Accordingly, PARVG appears not to be a tumor suppressor gene involved in CRC and breast cancer development and progression.
Castellví-Bel
Sergi
S
Department of Gastroenterology, Institut de Malalties Digestives, Hospital Clínic, Barcelona, Catalonia, Spain.
Castells
Antoni
A
Johnstone
Cameron N
CN
Piñol
Virgínia
V
Pellisé
Maria
M
Elizalde
Josep I
JI
Romo
Neus
N
Rustgi
Anil K
AK
Piqué
Josep M
JM
D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22; D015179:Colorectal Neoplasms / Q000235:genetics*; D017931:DNA Primers; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D009154:Mutation; D018807:Polymorphism, Single-Stranded Conformational
D017931:DNA Primers