Potential applications of matrix metalloproteinase inhibitors in geriatric practice.
Matrix metalloproteinases are a family of enzymes that degrade different components of extracellular matrix. They play an important role in normal physiologic processes of maintaining tissue integrity and remodeling, as in wound healing, processes of development, and regeneration. However, excessive expression of MMP has been observed in many disease states, including rheumatoid arthritis and osteoarthritis, vascular remodeling in atherosclerosis and aortic aneurysm formation, neoplastic processes, macular degeneration and many others.
Marder
Galina
G
Department of Rheumatology, Long Island Jewish Medical Center, New York, NY, USA. marder@lij.edu, rgreen@lij.edu
Greenwald
Robert A
RA
D000368:Aged; D001014:Aortic Aneurysm / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control*; D005853:Geriatrics; D006801:Humans; D008268:Macular Degeneration / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control*; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000502:physiology*; D010003:Osteoarthritis / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control*; D010818:Practice Patterns, Physicians'; D012307:Risk Factors
D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases