Successful treatment of anabolic steroid-induced azoospermia with human chorionic gonadotropin and human menopausal gonadotropin.
OBJECTIVE
To document for the first time the successful treatment using human chorionic gonadotropin (hCG) and human menopausal gonadotropins (hMG) of anabolic steroid-induced azoospermia that was persistent despite 1 year of cessation from steroid use.


METHODS
Clinical case report.


METHODS
Tertiary referral center for infertility.


METHODS
A married couple with primary subfertility secondary to azoospermia and male hypogonadotropic hypogonadism. The husband was a bodybuilder who admitted to have used the anabolic steroids testosterone cypionate, methandrostenolone, oxandrolone, testosterone propionate, oxymetholone, nandrolone decanoate, and methenolone enanthate.


METHODS
Twice-weekly injections of 10,000 IU of hCG (Profasi; Serono) and daily injections of 75 IU of hMG (Humegon; Organon) for 3 months.


METHODS
Semen analyses, pregnancy.


RESULTS
Semen analyses returned to normal after 3 months of treatment. The couple conceived spontaneously 7 months later.


CONCLUSIONS
Steroid-induced azoospermia that is persistent after cessation of steroid use can be treated successfully with hCG and hMG.
Menon
Dev Kumar
DK
Department of Obstetrics and Gynecology, University Malaya Medical Centre, Kuala Lumpur, Malaysia. drmenon2000@yahoo.co.uk
D000328:Adult; D045930:Anabolic Agents / Q000009:adverse effects*; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D009845:Oligospermia / Q000139:chemically induced / Q000188:drug therapy*
D045930:Anabolic Agents; D006063:Chorionic Gonadotropin; D008596:Menotropins