Activating MAP KAP kinase 2.
The crystal structures of MAP KAP kinase 2 in complex with ADP and staurosporine suggest a major reorganization of the glycine-rich loop upon ligand binding. The main determinant for the catalytic activity of MAP KAP kinase 2 is phosphorylation by p38 MAP kinase.
ter Haar
Ernst
E
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D004789:Enzyme Activation; D047908:Intracellular Signaling Peptides and Proteins; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry* / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D019311:Staurosporine / Q000378:metabolism; D048051:p38 Mitogen-Activated Protein Kinases; D000099190:MAP-Kinase-Activated Kinase 2
D000244:Adenosine Diphosphate; D047908:Intracellular Signaling Peptides and Proteins; D020928:Mitogen-Activated Protein Kinases; D017346:Protein Serine-Threonine Kinases; D019311:Staurosporine; D048051:p38 Mitogen-Activated Protein Kinases; D000099190:MAP-Kinase-Activated Kinase 2