[The effect of time on the perception of dyspnea following inhaled long-acting bronchodilator].
OBJECTIVE
To assess the effect of time on the change in the perception of dyspnea (POD) following inhalation of long-acting bronchodilator.


METHODS
Spirometry and the POD were measured in 32 asthmatic patients, with moderate asthma, before and following inhalation of placebo, and salmeterol. The POD was measured while breathing against progressive loads, using a visual analogue scale (VAS).


RESULTS
The highest FEV1 levels and the lowest POD were measured one hour after salmeterol inhalation. Although the mean FEV1 remained close to its peak value for at least six hours following the inhalation of salmeterol, there was a gradual statistically significant increase in the POD.


CONCLUSIONS
Following inhalation of long-acting bronchodilator (LABD) there is relationship between the increase in the FEV1 and the decrease in POD. With time there is a gradual increase in the perception of dyspnea regardless of the FEV1.
Weiner
Paltiel
P
Department of Medicine A, Hillel-Yaffe Medical Center, Hadera, Israel.
Magadle
Rasmi
R
Beckerman
Marinella
M
Berar-Yanay
Noa
N
D000280:Administration, Inhalation; D000420:Albuterol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004417:Dyspnea / Q000209:etiology*; D005541:Forced Expiratory Volume; D006801:Humans; D010465:Perception; D010919:Placebos; D000068299:Salmeterol Xinafoate; D013997:Time Factors
D001993:Bronchodilator Agents; D010919:Placebos; D000068299:Salmeterol Xinafoate; D000420:Albuterol