[The influence of continuous renal replacement therapy on the plasma levels of endotoxin and cytokines in severely burned patients with sepsis].
OBJECTIVE
To investigate the influence of continuous renal replacement therapy (CRRT) on the plasma levels of endotoxin and cytokines in severely burned patients with sepsis.


METHODS
Ten burn patients who received CRRT and another 10 without CRRT were investigated in terms of the changes in their plasma concentrations of endotoxin and some cytokines (TNFalpha, IL-1beta, IL-6, IL-8).


RESULTS
The plasma concentrations of endotoxin and all the cytokines (TNFalpha, IL-1beta, IL-6, IL-8) after CRRT treatment were significantly lower than those before the treatment (P < 0.01), and the plasma levels of the above factors at all the time points after CRRT treatment than those in patients were evidently lower by routine treatment (P < 0.05 - 0.01).


CONCLUSIONS
CRRT treatment could effectively lower the plasma levels of endotoxin and some cytokines (TNFalpha, IL-1beta, IL-6, IL-8).
Li
Hong-Bin
HB
Institute of Burn Research, Southwestern Hospital, The Third Military Medical University, Institute of Organ Transplantation Research of Chongqing City. Chongqing, 400038. P.R. China.
Peng
Yi-Zhi
YZ
D002056:Burns / Q000097:blood* / Q000150:complications; D004731:Endotoxins / Q000097:blood*; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D017582:Renal Replacement Therapy; D018805:Sepsis / Q000097:blood* / Q000209:etiology / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D004731:Endotoxins; D053583:Interleukin-1beta; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha