title: Beneficial effect of coronary artery bypass grafting as assessed by quantitative gated single-photon emission computed tomography.
abstract: The development of quantitative gated single-photon emission computed tomography (SPECT) has enabled the assessment of left ventricular perfusion, function and wall thickness in a single examination. Accordingly, the present study used gated SPECT to assess the benefit of coronary artery bypass grafting (CABG) in patients with coronary artery disease; 47 of those patients were evaluated before and 5 months after CABG. As a result of coronary revascularization, a significant improvement was observed in global ejection fraction (50+/-12 --> 53+/-11%; p<0.05). In 107 revascularized territories, the average regional reversible defect score (0.8+/-0.5 --> 0.2 +/-0.3; p<0.0001), average regional perfusion score at rest (0.6+/-0.6 --> 0.3+/-0.4; p<0.0001), average regional wall motion score (0.9+/-0.7 --> 0.7+/-0.5; p<0.05), and end-diastolic wall thickness (8.1+/-1.3 --> 8.6+/-1.5 mm; p<0.0005) all improved significantly. Even in 34 non-revascularized territories, the average regional reversible defect score (0.5+/-0.7 --> 0.2+/-0.5; p<0.03), average regional wall motion score (0.8+/-1.1 --> 0.5 +/-1.0; p<0.03) and end-diastolic wall thickness (8.0+/-1.4 --> 9.1+/-2.0 mm; p<0.03) all improved significantly. These results indicate that improvement in myocardial ischemia, hibernation and left ventricular function with CABG can be assessed in detail with gated SPECT.
authors.affiliation: Department of Internal Medicine II, Tokyo Medical University, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hida
authors.forename: Taishiro
authors.initials: T
authors.lastname: Chikamori
authors.forename: Tetsuzo
authors.initials: T
authors.lastname: Hirayama
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Usui
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Yanagisawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Morishima
authors.forename: Shin
authors.initials: S
authors.lastname: Ishimaru
authors.forename: Akira
authors.initials: A
authors.lastname: Yamashina
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass; D003971:Diastole; D017558:Elective Surgical Procedures; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000503:physiopathology; D017682:Myocardial Stunning / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D013318:Stroke Volume; D013599:Systole; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D016896:Treatment Outcome; D016277:Ventricular Function, Left