title: [MR angiography of the coronary arteries: comparison of the blood pool contrast medium Gadomer and Gd-DTPA in pigs].
abstract: OBJECTIVE
  To investigate the signal-enhancing effects of the macromolecular contrast medium Gadomer in MR angiography of the coronary arteries compared to Gd-DTPA.
  
  
  METHODS
  A total of 15 MRI examinations of the heart were performed in pigs at 1.5 T using a pulse-triggered, segmented 3D FLASH sequence with data acquisition during breathhold before and up to 30 min after contrast medium injection. Gadomer was investigated at two doses (0.05 and 0.1 mmol Gd/kg), Gd-DTPA at one (0.3 mmol Gd/kg) (n = 5 examinations per dose). Standard sequences without magnetization preparation were supplemented by sequences with magnetization saturation applied before data acquisition before and immediately after contrast medium injection. Analysis comprised quantitative determination of blood and myocardium signal to noise (S/N) and contrast to noise (C/N) and qualitative assessment of several parameters of image quality and coronary artery visualization.
  
  
  RESULTS
  Gadomer leads to a significant C/N increase between blood and myocardium compared to the unenhanced examination and the increase is longer-lasting than that produced by Gd-DTPA (Gd-DTPA: only directly after injection; Gadomer: up to 5 min post injection at 0.05 mmol Gd/kg, up to 10 min at 0.1 mmol Gd/kg). The qualitative evaluation shows that visualization of the coronary arteries and branch vessels is significantly better with Gadomer at both doses than with Gd-DTPA. Magnetization saturation increases the C/N in combination with Gd-DTPA and at the higher dose of Gadomer with the latter producing a higher increase in C/N values.
  
  
  CONCLUSIONS
  Gadomer is a suitable contrast medium for MR angiography of the coronary arteries with the dose of 0.1 mmol Gd/kg being superior to 0.05 mmol Gd/kg due to a longer imaging window.
authors.affiliation: Institut für Radiologie, Charité, Medizinische Fakultät der Humboldt Universität zu Berlin. joerg.schnorr@charite.de
authors.forename: J
authors.initials: J
authors.lastname: Schnorr
authors.forename: S
authors.initials: S
authors.lastname: Wagner
authors.forename: W
authors.initials: W
authors.lastname: Ebert
authors.forename: C
authors.initials: C
authors.lastname: Heyer
authors.forename: G
authors.initials: G
authors.lastname: Laub
authors.forename: D
authors.initials: D
authors.lastname: Kivelitz
authors.forename: C
authors.initials: C
authors.lastname: Abramjuk
authors.forename: B
authors.initials: B
authors.lastname: Hamm
authors.forename: M
authors.initials: M
authors.lastname: Taupitz
mesh_terms: D000818:Animals; D016477:Artifacts; D003287:Contrast Media / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003327:Coronary Disease / Q000175:diagnosis*; D003331:Coronary Vessels / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005682:Gadolinium / Q000493:pharmacokinetics; D019786:Gadolinium DTPA / Q000493:pharmacokinetics; D007275:Injections, Intravenous; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008657:Metabolic Clearance Rate / Q000502:physiology; D012680:Sensitivity and Specificity; D013552:Swine; D013556:Swine, Miniature
chemical_list: D003287:Contrast Media; C402765:gadomer 17; D005682:Gadolinium; D019786:Gadolinium DTPA