A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions.
Olsen
Jacob A
JA
Laboratorium für Organische Chemie, ETH-Hönggerberg, HCI, 8093 Zürich, Switzerland.
Banner
David W
DW
Seiler
Paul
P
Obst Sander
Ulrike
U
D'Arcy
Allan
A
Stihle
Martine
M
Müller
Klaus
K
Diederich
François
F
D001665:Binding Sites; D018360:Crystallography, X-Ray; D005461:Fluorine / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D014357:Trypsin / Q000737:chemistry / Q000378:metabolism
D008024:Ligands; D015842:Serine Proteinase Inhibitors; D005461:Fluorine; D014357:Trypsin; D013917:Thrombin