title: [Hepatotoxicity of chemotherapy].
abstract: Patients who will receive chemotherapy require careful assessment of liver function prior to treatment to determine which drugs are not appropriate, and which drug need dose modification. Many medications, alcohol has their more or less hepatotoxic effect, so because of their immunocompromise state, some body are prone to liver infection, including viral hepatitis. Lamivudine is effective in treating hepatitis B reactivation during chemotherapy. Now, the increased use of high-dose regimens with bone marrow or stem-cell support has been shown the drugs toxicities complication more, which does not observed in with conventional doses. Clinical judgment and a high index of suspicion remain critical tool in preventing and treating hepatic manifestations of cancer chemotherapy.
authors.affiliation: Department of Chemotherapy, Tokyo Metropolitan Komagome Hospital.
authors.forename: Rumiko
authors.initials: R
authors.lastname: Okamoto
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Maeda
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy / Q000517:prevention & control; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents