Chemokines: roles in leukocyte development, trafficking, and effector function.
Chemokines, representing a large superfamily of 8- to 15-kd proteins, were originally discovered through their ability to recruit various cell types into sites of inflammation. It is now clear that these molecules play a much wider role in immune homeostasis, playing key roles in driving the maturation, homing, and activation of leukocytes. In this review we analyze the roles chemokines play in the development, recruitment, and activation of leukocytes. Because signaling from the receptors drives these processes, signal transduction from chemokine receptors will also be reviewed. Taken together, we highlight the various points at which chemokines contribute to allergic inflammation and at which their targeting might contribute to new therapies for type I hypersensitivity reactions.
Ono
Santa Jeremy
SJ
Department of Immunology, Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.
Nakamura
Takao
T
Miyazaki
Dai
D
Ohbayashi
Masaharu
M
Dawson
Maria
M
Toda
Masako
M
D002454:Cell Differentiation; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology*; D002634:Chemotaxis, Leukocyte; D016503:Drug Delivery Systems; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000628:therapy; D007962:Leukocytes / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology; D018448:Models, Immunological; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction
D018925:Chemokines; D019707:Receptors, Chemokine