title: [Pregnancy of 18 women survivors of childhood cancer].
abstract: To analyze the effect of cancer treatment on pregnancy, delivery and progeny of women survivors of childhood cancer, 18 of them (15 to 49 years of age) were interviewed, with diagnosis and treatment between july 1965 and December 1982 (15 from the Oncology Unit of the Children's Hospital of Buenos Aires and 3 from a private practice) and evaluated until December 2000. The following potential determinants to suffer adverse effects on pregnancy, delivery and descendence were considered: laparotomy, alkylating agents, doxorubicine, infradiaphragmatic radiotherapy. Diagnoses were: non-Hodgkin lymphoma 6, nephroblastoma 5, retinoblastoma 3, osteosarcoma 1, fibrosarcoma 1, Langerhans cell histiocytosis 2. Ten patients were laparotomized, 11 were treated with alkylating agents, 8 with doxorubicin and 7 with infradiaphragmatic radiotherapy. Twenty-eight offsprings were born. Congenital anomalies were not detected. Inherited cancer was observed in two siblings whose mother had suffered bilateral retinoblastoma. Additional follow-up from woman survivors of childhood cancer is necessary to determine the effect of cancer and its treatment on pregnancy, delivery and offspring.
authors.affiliation: Unidad Oncología, Hospital de Niños Ricardo Gutiérrez, Gallo 1330, 1425 Buenos Aires, Argentina. laurabey@xlnet.com.ar
authors.forename: Laura
authors.initials: L
authors.lastname: Schwartz
authors.forename: Maŕia Leticia
authors.initials: ML
authors.lastname: Pons
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D004317:Doxorubicin / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology*; D007813:Laparotomy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D036801:Parturition; D011247:Pregnancy / Q000187:drug effects / Q000528:radiation effects; D011248:Pregnancy Complications / Q000209:etiology; D011256:Pregnancy Outcome; D011878:Radiotherapy / Q000009:adverse effects; D017741:Survivors
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin