Restoration of reproductive potential following expiration or removal of melengestrol acetate contraceptive implants in golden lion tamarins (Leontopithecus rosalia).
Although reversible contraception is important to successful management of small populations, there are concerns about the reversibility of melengestrol acetate (MGA), the most commonly used implant in captive animals. Female golden lion tamarins (Leontopithecus rosalia) placed in potential breeding situations after surgical MGA implant removal showed a 75% return to reproduction within 2 yr, unlike golden-headed tamarins (Leontopithecus chrysomelas), which have had a 29% return to reproduction following implant removal. This rate was indistinguishable from the breeding probability for newly formed pairs involving nonimplanted females. Litter size, stillbirth rate, and infant survival rate were not significantly different between nonimplanted and implant-removed female golden lion tamarins. However, females with implants left in (and assumed to have expired) showed higher stillbirth and infant mortality rates than did females with implants removed. For seven female golden lion tamarins for which reproductive histories before and after MGA implantation were available, litter size was unaffected by MGA implantation and subsequent removal. Infant survival rate for these females appeared to be lower after removal but was indistinguishable from rates in the nonimplanted females. Prior reproductive experience, length of time with an implant, and age of the females did not affect the probability of breeding for females after removal of the implants. Overall, breeding probability of nonimplanted females declined with age. Although the results of this study confirm the reversibility of MGA implants in golden lion tamarins, there appear to be some effects on viability of offspring, particularly offspring born to females with implants left in and presumed expired.
Wood
C
C
Department of Animal Sciences, Cornell University, Ithaca, New York 14583, USA.
Ballou
J D
JD
Houle
C S
CS
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D000836:Animals, Zoo; D001947:Breeding; D002143:Callitrichinae / Q000502:physiology*; D003267:Contraception / Q000009:adverse effects / Q000662:veterinary; D004343:Drug Implants; D005260:Female; D005313:Fetal Death / Q000139:chemically induced / Q000453:epidemiology / Q000662:veterinary; D008098:Litter Size / Q000187:drug effects; D008552:Melengestrol Acetate / Q000009:adverse effects*; D011247:Pregnancy; D045167:Progesterone Congeners / Q000009:adverse effects*; D016016:Proportional Hazards Models; D012098:Reproduction / Q000187:drug effects*; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors
D004343:Drug Implants; D045167:Progesterone Congeners; D008552:Melengestrol Acetate