title: Effects of alkali metal ions on some virulence traits of Candida albicans.
abstract: The effects of the alkali metal ions (Li+, Na+ and K+) on the growth and on certain virulence factors (adhesion, cell-surface hydrophobicity and germinating ability) of Candida albicans were determined. High concentrations of these ions displayed an inhibitory effect on the growth of the Candida cells; preincubation in their presence showed a negative effect on all virulence factors studied. The changes induced during the preincubation remained there even when high concentration of the ions was removed from the cell suspension. In contrast, a considerable growth was found at high Na+ and K+ concentrations. Although alkali metal ions significantly decreased certain virulence traits of the fungus they did not totally inhibit adhesion and germ-tube formation. This suggests that C. albicans may represent a health hazard even at a high salt concentration.
authors.affiliation: Department of Prosthodontics, Faculty of Dentistry, Semmelweis University, Budapest, Hungary.
authors.forename: P
authors.initials: P
authors.lastname: Hermann
authors.forename: K
authors.initials: K
authors.lastname: Forgács
authors.forename: E
authors.initials: E
authors.lastname: Gál
authors.forename: B
authors.initials: B
authors.lastname: Lenkey
authors.forename: G
authors.initials: G
authors.lastname: Nagy
authors.forename: F
authors.initials: F
authors.lastname: Rozgonyi
mesh_terms: D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development* / Q000472:pathogenicity*; D002448:Cell Adhesion; D057927:Hydrophobic and Hydrophilic Interactions; D008094:Lithium / Q000494:pharmacology; D008672:Metals, Alkali / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology; D013499:Surface Properties; D037521:Virulence Factors
chemical_list: D008672:Metals, Alkali; D037521:Virulence Factors; D008094:Lithium; D012964:Sodium; D011188:Potassium