title: Thrombophilic markers in patients with congenital bleeding disorders.
abstract: We have studied the presence or absence of thrombophilic markers in 59 patients with congenital bleeding disorders. Theoretically, the coexistence of coagulation factor deficiency and thrombophilia in patients with haemophilia may cause the bleeding tendency to decline. In 8 cases we have found thrombophilic marker positivity, in 7 patients APC resistance and in 1 patient protein S deficiency has been revealed. The presence of thrombophilic markers did not affect the frequency of bleeding episodes or the development of haemophilic arthropathy. The factor concentrate utilization, however, was lower in the group carrying thrombophilic markers, which indicates that the bleeding episodes were less severe. Relying on the strength of these findings, the medicinal influencing of inhibitor mechanisms may present itself as a potential therapy.
authors.affiliation: Transfusion Department, University of Szeged, Pécsi, u. 4B, H-6720 Szeged, Hungary. kvezendi@hotmail.com
authors.forename: K
authors.initials: K
authors.lastname: Vezendi
authors.forename: K
authors.initials: K
authors.lastname: Tápai
authors.forename: E
authors.initials: E
authors.lastname: Erdödi
authors.forename: I
authors.initials: I
authors.lastname: Szabó
authors.forename: A
authors.initials: A
authors.lastname: Tomek
authors.forename: J
authors.initials: J
authors.lastname: Oszlács
authors.forename: E
authors.initials: E
authors.lastname: Scheibl
mesh_terms: D020016:Activated Protein C Resistance; D000293:Adolescent; D000328:Adult; D000368:Aged; D000991:Antithrombins / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D020147:Coagulation Protein Disorders / Q000097:blood*; D005168:Factor VII Deficiency / Q000097:blood; D005260:Female; D006467:Hemophilia A / Q000097:blood; D002836:Hemophilia B / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000032:analysis; D019851:Thrombophilia / Q000097:blood*
chemical_list: D000991:Antithrombins; D015415:Biomarkers; D011486:Protein C; D017293:Protein S