[Modeling features of induction of long term potentiation in pyramidal neurons in the CA3 hippocampal region].
The conditions for inducing the long-term potentiation in the hippocampus were analyzed using the mathematical model of a CA3 pyramidal cell. Their dependence on the physiological characteristics of the neuron, the basic biochemical processes, and inhibitory efficacy was considered. The role of additional membrane depolarization in the origination of the hysteresis of the number of phosphorylated receptors as the basis for the formation of an "intermediate" stage of long-term potentiation was studied.
Murzina
G B
GB
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, ul. Butlerova 5a, Moscow, 117485 Russia.
D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D017774:Long-Term Potentiation; D008954:Models, Biological; D009474:Neurons / Q000502:physiology*