Antioxidant activity of Baccharis articulata extracts: isolation of a new compound with antioxidant activity.
Baccharis articulata is traditionally used as diuretic and digestive in local folk medicine of south of Brazil, Uruguay and Argentina. The antioxidant activity of crude ethanol and aqueous extracts, together with ethyl acetate and n-butanol fractions obtained from aqueous extract of B. articulata was determined using TRAP and TBARS assays. The n-butanol fraction was found to be the most active and its major compound (BaII) was isolated, identified and assayed. The structure of the phenolic compound BaII was established by means of spectroscopic and chemical methods as 4'-O-beta-D-glucopyranosyl-3',5'-dimethoxybenzyl-caffeate. This previously unreported metabolite presented similar antioxidant capacity when compared to Trolox.
De Oliveira
Simone Q
SQ
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Ipiranga, 2752, Porto Alegre, RS, 90610-000, Brazil.
Dal-Pizzol
Felipe
F
Gosmann
Grace
G
Guillaume
Dominique
D
Moreira
José Cláudio F
JC
Schenkel
Eloir P
EP
D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D031175:Baccharis / Q000737:chemistry*; D002839:Chromans / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D012708:Sertoli Cells / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D012717:Sesquiterpenes / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013997:Time Factors
D000975:Antioxidants; D002839:Chromans; D005609:Free Radicals; D010936:Plant Extracts; D012717:Sesquiterpenes; D017392:Thiobarbituric Acid Reactive Substances; C013828:baileyolin; D006861:Hydrogen Peroxide; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid