title: Modular modeling of cellular systems with ProMoT/Diva.
abstract: BACKGROUND
  Need for software to setup and analyze complex mathematical models for cellular systems in a modular way, that also integrates the experimental environment of the cells.
  
  
  RESULTS
  A computer framework is described which allows the building of modularly structured models using an abstract, modular and general modeling methodology. With this methodology, reusable modeling entities are introduced which lead to the development of a modeling library within the modeling tool ProMot. The simulation environment Diva is used for numerical analysis and parameter identification of the models. The simulation environment provides a number of tools and algorithms to simulate and analyze complex biochemical networks. The described tools are the first steps towards an integrated computer-based modeling, simulation and visualization environment Availability: Available on request to the authors. The software itself is free for scientific purposes but requires commercial libraries.
  
  
  BACKGROUND
  http://www.mpi-magdeburg.mpg.de/projects/promot
authors.affiliation: Max-Planck-Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, D-39106 Magdeburg, Germany. ginkel@mpi-magdeburg.mpg.de
authors.forename: M
authors.initials: M
authors.lastname: Ginkel
authors.forename: A
authors.initials: A
authors.lastname: Kremling
authors.forename: T
authors.initials: T
authors.lastname: Nutsch
authors.forename: R
authors.initials: R
authors.lastname: Rehner
authors.forename: E D
authors.initials: ED
authors.lastname: Gilles
mesh_terms: D000465:Algorithms; D002468:Cell Physiological Phenomena; D003198:Computer Simulation; D016208:Databases, Factual; D008660:Metabolism / Q000502:physiology*; D008954:Models, Biological; D012984:Software; D012985:Software Design; D014584:User-Computer Interface