title: Anti-tumor necrosis factor alpha monoclonal antibody (infliximab) for the treatment of Pyoderma gangrenosum associated with Crohn's disease.
abstract: Here we report a case of Pyoderma gangrenosum (PG) associated with Crohn's disease successfully treated with infliximab. The efficacy of this drug in many inflammatory diseases has already been reported, but its use in PG has only been seen in very few cases. Our study confirms that this therapy is a valid alternative solution for treating PG, which is often unresponsive to conventional therapies.
authors.affiliation: Institute for Cancer Research and Treatment (IRCC), Operative Unit of Dermatologic Surgery, Str.Prov.142, Km 3.95, 10060 Candiolo, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Zaccagna
authors.forename: Alberto
authors.initials: A
authors.lastname: Bertone
authors.forename: Paolo
authors.initials: P
authors.lastname: Puiatti
authors.forename: Franco
authors.initials: F
authors.lastname: Picciotto
authors.forename: Tatiana
authors.initials: T
authors.lastname: Sprujevnik
authors.forename: Renato
authors.initials: R
authors.lastname: Santucci
authors.forename: Francesco Paolo
authors.initials: FP
authors.lastname: Rossini
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use*; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D003937:Diagnosis, Differential; D016523:Foot Ulcer / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D000069285:Infliximab; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab