Neurotensin agonists: possible drugs for treatment of psychostimulant abuse.
Although many neuropeptides have been implicated in the pathophysiology of psychostimulant abuse, the tridecapeptide neurotensin holds a prominent position in this field due to the compelling literature on this peptide and psychostimulants. These data strongly support the hypothesis that a neurotensin agonist will be clinically useful to treat the abuse of psychostimulants, including nicotine. This paper reviews the evidence for a role for neurotensin in stimulant abuse and for a neurotensin agonist for its treatment.
Richelson
Elliott
E
Mayo Clinic Jacksonville, 4500 San Pablo Road, FL 32224, USA. richel@mayo.edu
Boules
Mona
M
Fredrickson
Paul
P
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D009496:Neurotensin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D018028:Receptors, Neurotensin / Q000819:agonists* / Q000037:antagonists & inhibitors; D019966:Substance-Related Disorders / Q000188:drug therapy* / Q000378:metabolism
D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D010446:Peptide Fragments; D018028:Receptors, Neurotensin; C407426:neurotensin 69L; D009496:Neurotensin