Finally, worm polycomb-like genes meet Hox regulation.
Polycomb and Trithorax group proteins have been shown to regulate Hox gene expression in flies and mammals, but not in worms. Two reports in this issue of Developmental Cell establish a first link between Polycomb-like genes and Hox gene regulation in C. elegans. However, sequence comparison indicates that these genes may not be homologous to the fly Polycomb genes, suggesting that independent gene recruitment occurred during nematode evolution.
Pires-daSilva
André
A
Max-Planck Institut für Entwicklungsbiologie, Abteilung Evolutionsbiologie, Spemannstrasse 37-39, D-72076, Tübingen, Germany.
Sommer
Ralf J
RJ
D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000254:growth & development*; D019143:Evolution, Molecular; D018507:Gene Expression Regulation, Developmental; D017238:Genes, Helminth; D005801:Genes, Homeobox; D015801:Helminth Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D009154:Mutation; D010802:Phylogeny; D012097:Repressor Proteins / Q000378:metabolism
D015801:Helminth Proteins; D012097:Repressor Proteins