title: Inhibitory effects of furanocoumarins isolated from the roots of Angelica dahurica on prostaglandin E2 production.
abstract: We have isolated five furanocoumarins, byakangelicin, phellopterin, imperatorin, isoimperatorin, and oxypeucedanin methanolate, from the roots of Angelica dahurica (Umbelliferae) and prepared five semi-synthesized compounds by the partial reduction of each isolated furanocoumarin, and the effects of these compounds on lipopolysaccharide (LPS)-induced prostaglandin E2 (PGE2 ) production in rat peritoneal macrophages were examined. Among these compounds, imperatorin showed the most potent inhibitory activity on the LPS-induced PGE2 production. It also inhibited the LPS-induced expressions of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES). These findings suggest that the inhibitory effect of furanocoumarins on the LPS-induced PGE2 production is due to the inhibition of the expression of COX-2 and mPGES.
authors.affiliation: Laboratory of Pathophysiological Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan.
authors.forename: Hyun Seung
authors.initials: HS
authors.lastname: Ban
authors.forename: Soon Sung
authors.initials: SS
authors.lastname: Lim
authors.forename: Katsuya
authors.initials: K
authors.lastname: Suzuki
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Jung
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Lee
authors.forename: Yeon Sil
authors.initials: YS
authors.lastname: Lee
authors.forename: Kuk Hyun
authors.initials: KH
authors.lastname: Shin
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ohuchi
mesh_terms: D029969:Angelica; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051546:Cyclooxygenase 2; D015232:Dinoprostone / Q000378:metabolism*; D011564:Furocoumarins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D019746:Intramolecular Oxidoreductases / Q000187:drug effects / Q000378:metabolism; D007527:Isoenzymes / Q000187:drug effects / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D010537:Peritoneum / Q000166:cytology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D000071876:Prostaglandin-E Synthases; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000893:Anti-Inflammatory Agents; D011564:Furocoumarins; D007527:Isoenzymes; D008070:Lipopolysaccharides; D010936:Plant Extracts; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D019746:Intramolecular Oxidoreductases; D000071876:Prostaglandin-E Synthases; D015232:Dinoprostone