Heterogeneity of CD4(+) and CD8(+) T cells.
There is extensive plasticity in the T-cell response to antigen. Helper CD4(+) T cells, cytotoxic CD8(+) T cells, the progression from naïve to effector and memory T cells, and differentiation into Th1, Tc1, Th2 and Tc2 subsets have long been recognized. More recently it has become apparent that T-cell populations display additional diversity in terms of phenotype, anatomical distribution and effector function.
Woodland
David L
DL
Trudeau Institute, 100 Algonquin Avenue, Saranac Lake, New York, NY 12983, USA. dwoodland@trudeauinstitute.org
Dutton
Richard W
RW
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D016176:T-Lymphocyte Subsets / Q000145:classification / Q000276:immunology*