[Effects of angiotensin receptor inhibitors on cardiovascular endpoints--current and future evidence].
There is close relationship between hypertension, organ damage and cardiovascular mortality. The control of hypertension or the regression of organ abnormalities can cause reduction in mortality but this is to be proven by each drug. Similar degree of antihypertensive effect with different type og drugs can result in different amount of regression of left ventricular hypertrophy. Telmisartan can cause reduction of LVH even in small, non-hypotensive doses. Combination of ACE inhibitors and ARB has a lot of theoretical advantage, the available clinical data are positive however some conflicting data are to be clarified yet. The ongoing ONTARGET study will give answers to a lot of this questions in 4 years.
Karlócai
Kristóf
K
Országos Korányi Tbc és Pulmonológiai Intézet, Kardiológiai Osztály.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects*; D002986:Clinical Trials as Topic; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents