title: Is replication of hepatitis C virus a marker of activity of infectious process? (Findings of polymerase chain reaction and morphological analysis of liver biopsy specimens).
abstract: Comparative study of replication markers of hepatitis C virus in various biological substrates and evaluation of activity of chronic HCV infection in liver biopsy specimens showed that replication of hepatitis C virus and the number of HCV-infected hepatocytes did not promote liver damage in chronic hepatitis C. These findings indicate that the expression of antiviral reactions by liver parenchyma cells plays the key role in the morphogenesis of HCV infection.
authors.affiliation: Laboratory of Ultrastructural Bases of Pathology, Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
authors.forename: G I
authors.initials: GI
authors.lastname: Nepomnyashchikh
authors.forename: N P
authors.initials: NP
authors.lastname: Tolokonskaya
authors.forename: S V
authors.initials: SV
authors.lastname: Aidagulova
authors.forename: D L
authors.initials: DL
authors.lastname: Nepomnyashchikh
authors.forename: Yu Yu
authors.initials: YY
authors.lastname: Karavaeva
authors.forename: E G
authors.initials: EG
authors.lastname: Sakharova
authors.forename: G A
authors.initials: GA
authors.lastname: Mezentseva
authors.forename: E V
authors.initials: EV
authors.lastname: Batemirova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000502:physiology*; D006526:Hepatitis C / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000648:ultrastructure / Q000821:virology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D014779:Virus Replication