title: The treatment of multiple myeloma with docetaxel (an ECOG study).
abstract: BACKGROUND
  Docetaxel has activity against multiple malignancies. In a previous ECOG study of untreated patients with multiple myeloma, paclitaxel was found to have mild activity, but had excessive toxicity. Docetaxel was evaluated in patients with relapsing or refractory multiple myeloma.
  
  
  METHODS
  Well-documented patients with relapsing or refractory multiple myeloma, who had received no more than two prior combination chemotherapy regimens, were treated with docetaxel 75 mgm(-2) intravenously over 1h every 3 weeks. Patients were evaluated after two and four cycles of treatment. Standard ECOG criteria were used to evaluate for response and toxicity.
  
  
  RESULTS
  The study accrued 31 patients with 28 eligible for response and 30 for toxicity analysis. No objective responses (partial or complete) were found. One patient died due to pneumonia. The majority of patients (80%) developed grade 3-4 granulocytopenia and 23% experienced grade 3-4 thrombocytopenia. The median number of cycles was three. The median survival was 9.9 months.
  
  
  CONCLUSIONS
  Docetaxel was inactive in patients with relapsing or refractory multiple myeloma. In addition, at 75 mgm(-2) every 3 weeks, there was extensive hematological toxicity. It is unlikely that a change in dose or a different schedule would significantly improve response, limit toxicity, and improve survival in patients with multiple myeloma.
authors.affiliation: Department of Hematology/Oncology, Guthrie Clinic, One Guthrie Square, Sayre, PA 18840, USA. wfriedenberg@clinic.guthrie.org
authors.forename: William R
authors.initials: WR
authors.lastname: Friedenberg
authors.forename: David
authors.initials: D
authors.lastname: Graham
authors.forename: Philip
authors.initials: P
authors.lastname: Greipp
authors.forename: Emily
authors.initials: E
authors.lastname: Blood
authors.forename: Robert D
authors.initials: RD
authors.lastname: Winston
mesh_terms: D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000633:toxicity; D000077143:Docetaxel; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D017239:Paclitaxel / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000633:toxicity; D016879:Salvage Therapy; D016019:Survival Analysis; D015996:Survival Rate; D043823:Taxoids; D013921:Thrombocytopenia / Q000139:chemically induced; D017211:Treatment Failure
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel