T-cell effector mechanisms: gammadelta and CD1d-restricted subsets.
Gammadelta T lymphocytes and CD1d-restricted natural killer T cells are classified as innate T lymphocytes, which perform effector functions that protect from malignancy and maintain tissue integrity. Innate T cells also play important regulatory roles in autoimmunity, inflammation and infection. Recent advances have established innate T cells as both effectors and regulators of disease in biological models.
Jameson
Julie
J
The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Witherden
Deborah
D
Havran
Wendy L
WL
D000818:Animals; D018949:Antigens, CD1 / Q000032:analysis*; D055610:Antigens, CD1d; D017209:Apoptosis; D001327:Autoimmune Diseases / Q000276:immunology; D006706:Homeostasis; D007239:Infections / Q000276:immunology; D018836:Inflammation Mediators / Q000502:physiology; D007694:Killer Cells, Natural / Q000276:immunology; D009369:Neoplasms / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000145:classification / Q000276:immunology*
D018949:Antigens, CD1; D055610:Antigens, CD1d; D018836:Inflammation Mediators; D016692:Receptors, Antigen, T-Cell, gamma-delta