title: [St. John's Wort (Hypericum perforatum): a plurivalent raw material for traditional and modern therapies].
abstract: St. John's Wort is one of the oldest and one of the best experimentally and clinically examined herbal remedies. In various medical cultures and medical systems--that is to say the regions of origin of Hypericum perforatum, like Europe, West Asia and North Africa--St. John's Wort has been used as a remedy for centuries. Preparations from St. John's Wort not only represent medical traditions but also ways of thinking, ideas and experiences from naturopathic healers (non-physicians) as well as patients. The complex multicompound with its evolutionary and coevolutionary developed composition and structure acts as a varied raw material for the production of quantitative and qualitative dissimilar remedies, which are multicompounds themselves. They differ not only analytically but also quite often in their effects. The certain and potential spectrum of internal and external uses includes gastrointestinal complaint and illness, skin disease, mucosal lesion, superficial injury, depressive upset and depression, somatoform disorders, restlessness, nervosity, convalescence, exhaustion, sleep disturbance and nursing treatment. The plurivalent character of the multicompound even enables a broad spectrum of activity. This might justify to prefer St. John's Wort to other drugs in a wide range of treatments: In tumor patients with depression the antioxidative effect and the experimentally documented induction of apoptosis could mean an additional advantage, and in depressive patients with coronary heart disease the same applies to the anti-inflammatory and antioxidative effects.
authors.affiliation: Abteilung Naturheilkunde, Departement für Innere Medizin, Universitätsspital Zürich, Switzerland. reinhard.saller@dim.usz.ch
authors.forename: R
authors.initials: R
authors.lastname: Saller
authors.forename: J
authors.initials: J
authors.lastname: Melzer
authors.forename: J
authors.initials: J
authors.lastname: Reichling
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy; D006801:Humans; D020902:Hypericum; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D010936:Plant Extracts