title: The epidemiology of malaria in Papua New Guinea.
abstract: Papua New Guinea (PNG) is a patchwork of different ecological zones, inhabited by human populations of exceptional cultural and linguistic diversity. This results in complex variations in vector ecology and malaria epidemiology. Malaria is the main cause of morbidity in many health facilities in lowland areas, but it is absent in much of the highlands. All four human malaria species occur, but endemicity varies widely, with Plasmodium falciparum locally reaching holo-endemic levels that are rarely found outside sub-Saharan Africa. The high frequency of Plasmodium vivax is an important difference to most African situations. PNG is therefore a prime location for studies of interactions between different parasite species, and of the biology of local human genetic adaptation and its implications for malaria morbidity and mortality.
authors.affiliation: Papua New Guinea Institute of Medical Research, Maprik, EHP 441, Papua New Guinea.
authors.forename: Ivo
authors.initials: I
authors.lastname: Müller
authors.forename: Moses
authors.initials: M
authors.lastname: Bockarie
authors.forename: Michael
authors.initials: M
authors.lastname: Alpers
authors.forename: Tom
authors.initials: T
authors.lastname: Smith
mesh_terms: D000818:Animals; D000852:Anopheles / Q000145:classification / Q000502:physiology; D004351:Drug Resistance; D006801:Humans; D015994:Incidence; D007303:Insect Vectors / Q000145:classification / Q000502:physiology; D008288:Malaria / Q000453:epidemiology* / Q000469:parasitology / Q000635:transmission; D018977:Micronutrients / Q000172:deficiency; D009032:Mosquito Control / Q000639:trends; D009748:Nutrition Disorders / Q000150:complications; D010219:Papua New Guinea / Q000453:epidemiology; D015995:Prevalence
chemical_list: D018977:Micronutrients