An indolent B-cell lymphoma with t(2;8)(p12;q24) abnormality and absence of C-MYC amplification and TP53 deletion. A new variant?
The translocation between chromosomes 2 and 8, t(2;8), is well known for its strong association with high-grade Burkitt lymphoma. However, the significance of this translocation in indolent lymphoproliferative disorders is not clear. We present the case of a 75-year-old white male with left upper quadrant abdominal pain, splenomegaly, and an elevated white cell count of 30.3x10(9) cells/L (84% large lymphoid cells with scanty cytoplasm and prominent central nucleoli). Immunophenotyping revealed a clonal B-cell population coexpressing CD5, CD19, and CD20 with weak CD23 and CD25 and very weak, restricted, surface lambda. The cytogenetic analysis showed all 20 cells with t(2;8)(p12;q24.3). In addition, four of the 20 cells also showed a second translocation: t(12;17)(p13;q21). Molecular analysis using c-myc and p53 probes showed normal results with no indication of amplification of C-MYC or deletion of TP53. The patient was managed as an indo-lent/low-grade lymphoproliferative disorder with excellent response to eight cycles of fludarabine.
Potti
Anil
A
Division of Hematology/Oncology, Veterans Affairs Medical Center, University of North Dakota School of Medicine, Fargo, ND 58102, USA. apotti@medicine.nodak.edu
Panwalkar
Amit
A
Ingebretson
Mark C
MC
Tharapel
Sugandhi A
SA
Goodell
Michael
M
Dayton
M V
MV
Mehdi
Syed A
SA
D000368:Aged; D002889:Chromosomes, Human, Pair 2; D002898:Chromosomes, Human, Pair 8; D005784:Gene Amplification; D016259:Genes, myc; D016158:Genes, p53; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging / Q000235:genetics*; D008297:Male; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic