Expression of cytokine genes in blood mononuclear cells in women with pyoinflammatory diseases of adnexa uteri.
Production of interleukin, interferon-gamma, and transforming growth beta(2)-factor mRNA in peripheral blood mononuclear cells was studied in women with pyoinflammatory diseases of adnexa uteri. Predominant expression of Th1 proinflammatory cytokine genes in patients was demonstrated. Production of interleukins 4 and 8 mRNA decreased 200- and 60-fold, respectively, in comparison with that in healthy women. One month and a half after extirpation of fallopian tubes the cytokine production in blood mononuclear cells shifted towards antiinflammatory cytokines, expression of interleukin-8 gene returned to normal, and expression of interleukin-4 gene increased.
Zhdanov
A V
AV
Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow.
Sosulina
L Yu
LY
Kurbanova
D F
DF
Van'ko
L V
LV
Sukhikh
G T
GT
D000328:Adult; D001483:Base Sequence; D016022:Case-Control Studies; D016207:Cytokines / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D015870:Gene Expression; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics; D016209:Interleukin-8 / Q000235:genetics; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D000292:Pelvic Inflammatory Disease / Q000235:genetics* / Q000276:immunology* / Q000628:therapy; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D016207:Cytokines; D016209:Interleukin-8; D015847:Interleukin-4; D004247:DNA