title: A miniaturized neuroprosthesis suitable for implantation into the brain.
abstract: This paper presents current research on a miniaturized neuroprosthesis suitable for implantation into the brain. The prosthesis is a heterogeneous integration of a 100-element microelectromechanical system (MEMS) electrode array, front-end complementary metal-oxide-semiconductor (CMOS) integrated circuit for neural signal preamplification, filtering, multiplexing and analog-to-digital conversion, and a second CMOS integrated circuit for wireless transmission of neural data and conditioning of wireless power. The prosthesis is intended for applications where neural signals are processed and decoded to permit the control of artificial or paralyzed limbs. This research, if successful, will allow implantation of the electronics into the brain, or subcutaneously on the skull, and eliminate all external signal and power wiring. The neuroprosthetic system design has strict size and power constraints with each of the front-end preamplifier channels fitting within the 400 x 400-microm pitch of the 100-element MEMS electrode array and power dissipation resulting in less than a 1 degree C temperature rise for the surrounding brain tissue. We describe the measured performance of initial micropower low-noise CMOS preamplifiers for the neuroprosthetic.
authors.affiliation: NASA Jet Propulsion Laboratory, Pasadena, CA 91109, USA. Mojarradi@jpl.nasa.gov
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mojarradi
authors.forename: David
authors.initials: D
authors.lastname: Binkley
authors.forename: Benjamin
authors.initials: B
authors.lastname: Blalock
authors.forename: Richard
authors.initials: R
authors.lastname: Andersen
authors.forename: Norbert
authors.initials: N
authors.lastname: Ulshoefer
authors.forename: Travis
authors.initials: T
authors.lastname: Johnson
authors.forename: Linda
authors.initials: L
authors.lastname: Del Castillo
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000669:Amplifiers, Electronic; D000703:Analog-Digital Conversion; D002540:Cerebral Cortex / Q000502:physiology / Q000601:surgery; D004567:Electrodes, Implanted; D019544:Equipment Failure Analysis; D008839:Microelectrodes; D008904:Miniaturization; D036103:Nanotechnology / Q000295:instrumentation; D009474:Neurons / Q000502:physiology; D019736:Prostheses and Implants; D011474:Prosthesis Design; D013686:Telemetry / Q000295:instrumentation