title: Use of neural networks for dosage individualisation of erythropoietin in patients with secondary anemia to chronic renal failure.
abstract: The external administration of recombinant human erythropoietin is the chosen treatment for those patients with secondary anemia due to chronic renal failure undergoing periodic hemodialysis. The goal is to carry out an individualised prediction of the erythropoietin dosage to be administered. It is justified because of the high cost of this medication, its secondary effects and the phenomenon of potential resistance which some individuals suffer. One hundred and ten patients were included in this study and several factors were collected in order to develop the neural models. Since the results obtained were excellent, an easy-to-use decision-aid computer application was implemented.
authors.affiliation: Digital Signal Processing Group, Department of Electronics Engineering, Faculty of Physics, University of València, C del Dr. Moliner 50, Burjassot 46100, València, Spain. jose.d.martin@uv.es
authors.forename: José D
authors.initials: JD
authors.lastname: Martín Guerrero
authors.forename: Emilio Soria
authors.initials: ES
authors.lastname: Olivas
authors.forename: Gustavo Camps
authors.initials: GC
authors.lastname: Valls
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Serrano López
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Pérez Ruixo
authors.forename: N Víctor Jiménez
authors.initials: NV
authors.lastname: Torres
mesh_terms: D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D004921:Erythropoietin / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000503:physiopathology; D016571:Neural Networks, Computer; D011788:Quality of Life; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin