title: A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions.
authors.affiliation: Laboratorium für Organische Chemie, ETH-Hönggerberg, HCI, 8093 Zürich, Switzerland.
authors.forename: Jacob A
authors.initials: JA
authors.lastname: Olsen
authors.forename: David W
authors.initials: DW
authors.lastname: Banner
authors.forename: Paul
authors.initials: P
authors.lastname: Seiler
authors.forename: Ulrike
authors.initials: U
authors.lastname: Obst Sander
authors.forename: Allan
authors.initials: A
authors.lastname: D'Arcy
authors.forename: Martine
authors.initials: M
authors.lastname: Stihle
authors.forename: Klaus
authors.initials: K
authors.lastname: Müller
authors.forename: François
authors.initials: F
authors.lastname: Diederich
mesh_terms: D001665:Binding Sites; D018360:Crystallography, X-Ray; D005461:Fluorine / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D014357:Trypsin / Q000737:chemistry / Q000378:metabolism
chemical_list: D008024:Ligands; D015842:Serine Proteinase Inhibitors; D005461:Fluorine; D014357:Trypsin; D013917:Thrombin