EEG does not predict response to valproate treatment of aggression in patients with borderline and antisocial personality disorders.
Previous investigations of the role of EEG in predicting response of aggressive patients to valproate therapy have yielded mixed results. In this study of borderline and antisocial personality disorder patients hospitalized with aggressive behavior, EEGs were obtained prior to treatment with valproate. Eight of 22 (36.4%) patients subsequently responsive to valproate had nonepileptiform EEG abnormalities, while 5 of 20 (25%) patients not responsive to valproate had nonepileptiform EEG abnormalities. Although more of the valproate responders than nonresponders had EEG abnormalities, the presence of nonepileptiform EEG abnormalities was not a statistically significant (X2 = 0.213, df = 1, p = 0.64) predictor of valproate response in personality disorder patients with aggression.
Reeves
Roy R
RR
Jackson VA Medical Center, Dept of Psychiatry (116A), 1500 E. Woodrow Wilson Drive, Jackson, MS 39216, USA. roy.reeves@med.va.gov
Struve
Frederick A
FA
Patrick
Gloria
G
D000328:Adult; D000374:Aggression / Q000187:drug effects*; D000927:Anticonvulsants / Q000627:therapeutic use*; D000987:Antisocial Personality Disorder / Q000188:drug therapy* / Q000503:physiopathology; D001883:Borderline Personality Disorder / Q000188:drug therapy* / Q000503:physiopathology; D016022:Case-Control Studies; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D014635:Valproic Acid / Q000627:therapeutic use*
D000927:Anticonvulsants; D014635:Valproic Acid