BEN/DM-GRASP/SC1 expression during mouse facial development: differential expression and regulation in molars and incisors.
The cell adhesion molecule BEN/DM-GRASP/SC1 is expressed in a variety of tissues during embryogenesis. Here, we studied the expression pattern of BEN/DM-GRASP/SC1 in different organs involved in facial mouse development, especially in the developing teeth. BEN/DM-GRASP/SC1 was expressed in nose, whisker, gland, and tongue epithelia, as well as in myogenic mesenchyme. In molars, BEN/DM-GRASP/SC1 was firstly expressed in the condensed mesenchyme and thereafter expression was confined to mesenchymal cells of the dental follicle. In contrast, in incisors, transient BEN/DM-GRASP/SC1 expression was restricted to epithelium. In tissue recombination experiments, BEN/DM-GRASP/SC1 expression in mesenchyme was activated by molar, but not incisor epithelium.
Fraboulet
Sandrine
S
UMR CNRS 5538, Institut Albert Bonniot, Université Joseph Fourier, 38706 Cedex, La Tronche, France.
Kavvadia
Katerina
K
Pourquié
Olivier
O
Sharpe
Paul T
PT
Mitsiadis
Thimios A
TA
D020410:Activated-Leukocyte Cell Adhesion Molecule / Q000096:biosynthesis / Q000235:genetics*; D000818:Animals; D015870:Gene Expression; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D007180:Incisor / Q000196:embryology*; D051379:Mice; D008963:Molar / Q000196:embryology*; D009928:Organ Specificity
D020410:Activated-Leukocyte Cell Adhesion Molecule