Diffusion-weighted imaging abnormalities in the splenium after seizures.
OBJECTIVE
Transient increased T2 signal in the splenium of the corpus callosum after seizures has been reported and sometimes attributed to a postulated toxicity of anticonvulsant medications (AEDs).


METHODS
We describe two patients with bitemporal epilepsy.


RESULTS
Transiently increased T2 signal (in one) and decreased apparent diffusion coefficient (ADC) (in both) in the splenium appeared to be related directly to acute seizures.


CONCLUSIONS
These cases illustrate an unusual acute postictal imaging finding, highlight involvement of an important commissural pathway, and suggest that seizures per se, and not their treatment, are the cause of transient white-matter abnormalities in these cases.
Oster
Joel
J
Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Doherty
Colin
C
Grant
P Ellen
PE
Simon
Mirela
M
Cole
Andrew J
AJ
D000208:Acute Disease; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D003337:Corpus Callosum / Q000503:physiopathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D004569:Electroencephalography / Q000379:methods / Q000706:statistics & numerical data; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D005500:Follow-Up Studies; D007839:Functional Laterality; D006801:Humans; D008297:Male; D014743:Videotape Recording
D000927:Anticonvulsants