title: Monosomy 7p in meningiomas: a rare constituent of tumor progression.
abstract: We present karyotypes of 15 meningiomas with structural aberrations of chromosome 7, which were taken from a consecutive series of 400 cytogenetically characterized meningiomas. Twelve of these tumors (80%) displayed partial or complete monosomy 7p with a consensus deleted region of 7p12 approximately pter, in 6 of 15 cases arising from an unbalanced whole-arm t(1;7)(q11;p11), and in 4 of 15 cases from a whole-arm translocation involving other chromosomes. Other types of partial aneusomy 7 (3/15 cases) or balanced aberrations of chromosome 7 (2/15 cases) were relatively rare. In most cases (11/15), the centromeric region of chromosome 7 was involved in the rearrangements. We conclude that in meningiomas, the near-centromeric region of chromosome 7 is particularly prone to structural rearrangements most frequently resulting in monosomy 7p. The investigation of the histopathologic features of this rare cytogenetic subgroup of meningiomas showed no clear genotype/phenotype correlation. As 7 of 11 of the meningiomas with monosomy 7p belonged to World Health Organization grades II or III, which usually comprise less than 20% of all meningiomas, partial loss of 7p appears to be involved in tumor progression in meningiomas. Because monosomy 7p is typically associated with the strongly progression-associated monosomy 1p, however, monosomy 7p represents a cofactor more than a stand-alone feature of meningioma progression.
authors.affiliation: Institute of Human Genetics, Saarland University, Homburg/Saar, Germany. wolfram.henn@uniklinik-saarland.de
authors.forename: Wolfram
authors.initials: W
authors.lastname: Henn
authors.forename: Isolde
authors.initials: I
authors.lastname: Niedermayer
authors.forename: Ralf
authors.initials: R
authors.lastname: Ketter
authors.forename: Sylvia
authors.initials: S
authors.lastname: Reichardt
authors.forename: Arno
authors.initials: A
authors.lastname: Freiler
authors.forename: Klaus D
authors.initials: KD
authors.lastname: Zang
mesh_terms: D000328:Adult; D000368:Aged; D002897:Chromosomes, Human, Pair 7; D018450:Disease Progression; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology*; D008579:Meningioma / Q000235:genetics* / Q000473:pathology*; D008875:Middle Aged; D009006:Monosomy