title: Relationship between response to and production of the aerial mycelium-inducing substances pamamycin-607 and A-factor.
abstract: Respectively, exogenous pamamycin-607 and A-factor restored or stimulated aerial mycelium formation in 30 (67%) and 6 (13%) of 45 Streptomyces strains, and both restored or stimulated it in 5 strains (11%). Pamamycin-607 production was detected in 3 of those strains that responded to pamamycin-607. These findings indicate that pamamycin-607 acts on the common regulatory system for aerial mycelium formation in Streptomyces spp. but is not a universal autoregulator. Increased or decreased antibacterial production occurred in 5 strains in association with aerial mycelium formation by pamamycin-607 or A-factor.
authors.affiliation: Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Saiwai-cho, Fuchu, Tokyo 183-8509, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kondo
authors.forename: Ikuko
authors.initials: I
authors.lastname: Kozone
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaide
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Abe
authors.forename: Masahiro
authors.initials: M
authors.lastname: Natsume
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006133:Growth Substances / Q000096:biosynthesis / Q000494:pharmacology*; D006706:Homeostasis; D018942:Macrolides; D025282:Mycelium / Q000187:drug effects / Q000254:growth & development*; D013302:Streptomyces / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D000900:Anti-Bacterial Agents; D006133:Growth Substances; D018942:Macrolides; C470905:pamamycin-607; C025035:A-factor (Streptomyces); D015107:4-Butyrolactone; D002118:Calcium