Synthesis and characterization of novel dipeptide ester prodrugs of acyclovir.
Four dipeptide (Gly-Gly, Gly-Val, Val-Val, Val-Gly) ester prodrugs of 9-[(2-hydroxyethoxy)methyl]guanine (acyclovir, ACV) were synthesized. LC/MS was used to characterize the new prodrugs. Both 1H NMR and 13C NMR spectra of the four prodrugs of ACV were measured and assigned based on spectral comparison with compounds of similar structures.
Nashed
Yasser E
YE
Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 5005 Rockhill Road, Kansas City, MO 64110-2499, USA.
Mitra
Ashim K
AK
D000212:Acyclovir / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D004952:Esters; D009682:Magnetic Resonance Spectroscopy; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry
D004151:Dipeptides; D004952:Esters; D011355:Prodrugs; D000212:Acyclovir