Evaluation of anti-hsp70 antibody screening in sudden deafness.
OBJECTIVE
To assess the diagnostic utility of anti-hsp70 antibody screening in sudden deafness.


METHODS
era from 27 patients with sudden deafness and 100 healthy blood donors were analyzed by Western blotting (WB) for the presence of antibodies against 68 kD heat shock protein (anti-hsp70).


RESULTS
19% of the patient sera and 14% of the control sera turned out positive, which was not significantly different.


CONCLUSIONS
The anti-hsp70 WB test lacks clinical utility for diagnostic screening in patients with sudden deafness.
Samuelsson
Anna-Karin
AK
Division of Rheumatology, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University Hospital, Linköping, Sweden.
Hydén
Dag
D
Roberg
Magnus
M
Skogh
Thomas
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D015153:Blotting, Western; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology*; D003639:Hearing Loss, Sudden / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D011446:Prospective Studies
D001323:Autoantibodies; D018840:HSP70 Heat-Shock Proteins