Synthesis and metal-binding properties of chelating fluorescein derivatives.
[reaction: see text] Two routes to highly functionalized metal-chelating fluorescein derivatives have been pursued. Compound 3 is partially quenched by a variety of first-row transition metal ions in aqueous solution, with EC(50) values ranging from 0.4 to 60 microM. Compounds of this type may find application in biological sensing.
Clark
Matthew A
MA
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Duffy
Kathryn
K
Tibrewala
Jyoti
J
Lippard
Stephen J
SJ
D002614:Chelating Agents / Q000737:chemistry*; D005452:Fluoresceins / Q000737:chemistry*; D008024:Ligands; D019216:Metals, Heavy / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
D002614:Chelating Agents; D005452:Fluoresceins; D008024:Ligands; D019216:Metals, Heavy