title: Pseudoachalasia caused by pancreatic carcinoma.
abstract: Secondary achalasia or pseudoachalasia is mostly caused by gastric or oesophageal carcinoma. Here we report a case of pseudoachalasia caused by a pancreatic tumour invading the cardiac region. A 66-year-old man with a 2-month history of dysphagia and weight loss showed no abnormalities on upper gastrointestinal endoscopy and computed tomography scan, but had no swallow-induced relaxation on oesophageal manometry. Based on the patient's history and oesophageal manometry findings, further investigation was performed to exclude pseudoachalasia. Endoscopic ultrasonography showed abnormalities in the cardiac region, but large endoscopic biopsies showed no malignancy. A laparotomy was performed, which revealed a large, irresectable tumour originating from the pancreatic corpus region and expanding into the gastric cardia region. This case illustrates that a pancreatic tumour invading the cardiac region may present as pseudoachalasia.
authors.affiliation: Department of Gastroenterology & Hepatology, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: Joanneke M
authors.initials: JM
authors.lastname: de Borst
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Wagtmans
authors.forename: Paul
authors.initials: P
authors.lastname: Fockens
authors.forename: J Jan
authors.initials: JJ
authors.lastname: van Lanschot
authors.forename: Rachel
authors.initials: R
authors.lastname: West
authors.forename: Guy E
authors.initials: GE
authors.lastname: Boeckxstaens
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D000368:Aged; D002299:Cardia / Q000473:pathology; D019160:Endosonography; D004931:Esophageal Achalasia / Q000209:etiology*; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology