title: A revised pharmacokinetic model for alcohol.
abstract: OBJECTIVE
  To correct a defect in widely utilised pharmacokinetic models of alcohol absorption into the blood.
  
  
  METHODS
  The implications of the defect are briefly described. A highly simplified model that corrects this defect is then proposed, and the resulting differential equation describing blood-alcohol concentration from ingestion to elimination is derived. The equation is solved in closed form.
  
  
  RESULTS
  The improved model assumes that diffusion of alcohol across the interface between the stomach/intestine complex and the remaining body fluids (including blood plasma) is linearly proportional to the difference in alcohol concentration across the interface. The resulting equation is tested against experimental data with excellent agreement.
  
  
  CONCLUSIONS
  This model enables inferences to be drawn that are not possible with the more conventional model.
authors.affiliation: Consultant, Buffalo, New York, USA. lotsof@calspan.com
authors.forename: Jack
authors.initials: J
authors.lastname: Lotsof
mesh_terms: D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics*; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D008433:Mathematics; D008954:Models, Biological; D013270:Stomach / Q000187:drug effects
chemical_list: D000431:Ethanol