title: Polymer-supported triazenes as smart reagents for the alkylation of carboxylic acids.
abstract: Starting from polystyrene, a simple four-step synthesis of polymer-supported alkyltriazenes (alkyl=Me, Et, benzyl) is described. With this synthesis, a loading capacity of 2.2 mmol g(-1) can be reached. The most prominent application of these polymer-supported reagents is the rapid, highly selective and high-yielding esterification of carboxylic acids, which involves a simple "mix and filter off" procedure at room temperature. If stored in a refrigerator, these reagents are stable for many months and they can be recycled several times.
authors.affiliation: Novartis Pharma, Chemical & Analytical Development, 4002 Basel, Switzerland.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Erb
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Kucma
authors.forename: Sandrine
authors.initials: S
authors.lastname: Mourey
authors.forename: Fritz
authors.initials: F
authors.lastname: Struber