title: Increased frequency of interleukin-1beta-511T allele in patients with temporal lobe epilepsy, hippocampal sclerosis, and prolonged febrile convulsion.
abstract: OBJECTIVE
  To confirm the high frequency of interleukin (IL)-1beta-511T allele occurrence in patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS), with special attention given to the impact of prolonged febrile convulsions (PFCs) on IL-1beta genotype distribution.
  
  
  METHODS
  Patients with evidence of unilateral HS on magnetic resonance (MR) images were chosen as study subjects (TLE+HS; n = 66). Other patients with essentially normal MRI findings or only foreign tissue (TLE without HS; TLE-HS; n = 64), and those with symptomatic localization-related epilepsy but without TLE (SLE; n = 89) were selected as disease controls. A single base pair polymorphism at position 2511 in the promoter region of the IL-1beta gene was analyzed.
  
  
  RESULTS
  The distribution of IL-1beta-511 genotypes as well as allele frequency was significantly different between TLE+HS patients and controls. In contrast, no difference was found between TLE-HS patients and controls or between SLE patients and controls. Further, in the group of patients with TLE+HS, the frequency of the IL-1beta-511T allele tended to increase as a function of febrile convulsions [0.531 without either PFC or simple febrile convulsion (SFC); 0.633 with SFC; 0.686 with PFC]. Although no statistically significant difference was noted between patients without PFC and the controls, a chi2 analysis of allele distribution revealed a significant difference between those with PFC and the controls.
  
  
  CONCLUSIONS
  PFC proved to be a potent determinant of IL-1beta-511T allele frequency; thus a discrepancy of PFC incidence should be considered an explanation of recent conflicting results regarding the association between the gene polymorphisms of IL-1beta-511 and TLE+HS.
authors.affiliation: Department of Neuropsychiatry Aichi Medical University, Nagakute Utano National Hospital, Kansai Regional Epilepsy Center, Kyoto, Japan. fwkh2919@mb.infoweb.ne.jp
authors.forename: Kousuke
authors.initials: K
authors.lastname: Kanemoto
authors.forename: Jun
authors.initials: J
authors.lastname: Kawasaki
authors.forename: Shoji
authors.initials: S
authors.lastname: Yuasa
authors.forename: Testuo
authors.initials: T
authors.lastname: Kumaki
authors.forename: Oshima
authors.initials: O
authors.lastname: Tomohiro
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kaji
authors.forename: Masataka
authors.initials: M
authors.lastname: Nishimura
mesh_terms: D000328:Adult; D017668:Age of Onset; D000483:Alleles; D004833:Epilepsy, Temporal Lobe / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012598:Sclerosis; D003294:Seizures, Febrile / Q000235:genetics*
chemical_list: D007375:Interleukin-1