title: A mitochondrial rhomboid protease.
abstract: Rhomboid proteases are integral membrane proteins, typically associated with cleavage of peptide hormones along the secretory pathway. Recent publications demonstrate that yeast mitochondria contain a rhomboid protease required for the cleavage of two mitochondrial intermembrane space proteins, suggesting that rhomboid proteases play a regulatory role in mitochondria.
authors.affiliation: Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.
authors.forename: Alexander M
authors.initials: AM
authors.lastname: van der Bliek
authors.forename: Carla M
authors.initials: CM
authors.lastname: Koehler
mesh_terms: D003578:Cytochrome-c Peroxidase / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism*; D020558:GTP Phosphohydrolases / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism*; D017353:Gene Deletion; D008565:Membrane Proteins / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D008954:Models, Biological; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
chemical_list: C082883:MGM1 protein, S cerevisiae; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D020033:Protein Isoforms; D029701:Saccharomyces cerevisiae Proteins; D003578:Cytochrome-c Peroxidase; D010450:Endopeptidases; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins