title: Cyclic amine sulfonamides as linkers in the design and synthesis of novel human beta(3) adrenergic receptor agonists.
abstract: Piperidine, pyrrolidine, and azetidine sulfonamides were examined as linkers in designing novel human beta(3) adrenergic receptor (beta(3)-AR) agonists. The azetidine derivative 37, and piperidine derivatives 7, 8, and 13 were found to be potent beta(3)-AR agonists and have good selectivity against beta(1)- and beta(2)-AR.
authors.affiliation: Chemical Sciences, Wyeth Research, 10965, Pearl River, NY, USA. sums@wyeth.com
authors.forename: Fuk Wah
authors.initials: FW
authors.lastname: Sum
authors.forename: Victoria
authors.initials: V
authors.lastname: Wong
authors.forename: Stella
authors.initials: S
authors.lastname: Han
authors.forename: Elwood
authors.initials: E
authors.lastname: Largis
authors.forename: Ruth
authors.initials: R
authors.lastname: Mulvey
authors.forename: Jeff
authors.initials: J
authors.lastname: Tillett
mesh_terms: D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D001384:Azetidines / Q000138:chemical synthesis / Q000494:pharmacology; D016466:CHO Cells; D006224:Cricetinae; D003500:Cyclization; D015195:Drug Design; D006801:Humans; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000494:pharmacology; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists; D001384:Azetidines; D010880:Piperidines; D011759:Pyrrolidines; D013449:Sulfonamides