Effect of radiation on prothrombin interactions with cell membrane fragments.
Binding of (125)I-labeled prothrombin to normal and radiation-damaged (1 and 3.5 Gy) fragments of cell membranes was studied. Irradiation significantly increased adsorption capacity of cell membranes for (125)I-prothrombin. It was concluded that phase rearrangement of phospholipids serves as the molecular basis for increased thrombogenicity of cell membranes.
Kiselev
S V
SV
Kazan State Medical University. dilja2001@mail.ru
Zubairov
D M
DM
Kirshin
S V
SV
D000818:Animals; D001013:Aorta, Thoracic / Q000293:injuries / Q000378:metabolism / Q000528:radiation effects; D002462:Cell Membrane / Q000378:metabolism* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007700:Kinetics; D008563:Membrane Lipids / Q000378:metabolism / Q000528:radiation effects; D010743:Phospholipids / Q000378:metabolism / Q000528:radiation effects; D011516:Prothrombin / Q000378:metabolism*; D011832:Radiation Injuries / Q000378:metabolism; D034421:Sus scrofa; D013927:Thrombosis / Q000209:etiology
D007457:Iodine Radioisotopes; D008563:Membrane Lipids; D010743:Phospholipids; D011516:Prothrombin