title: 1,3-dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis.
abstract: An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Sei-Joon
authors.initials: SJ
authors.lastname: Jeong
authors.forename: Masanori
authors.initials: M
authors.lastname: Inagaki
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Higuchi
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ono
authors.forename: Michihiko
authors.initials: M
authors.lastname: Kuwano
authors.forename: Rob W M
authors.initials: RW
authors.lastname: Van Soest
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D018360:Crystallography, X-Ray; D042783:Endothelial Cells / Q000187:drug effects*; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*
chemical_list: C107720:1,3-dimethylisoguanine; D020533:Angiogenesis Inhibitors; D006147:Guanine; D005346:Fibroblast Growth Factors