[Association of the SOD2 Ala(-9)Val and SOD3 Arg213Gly polymorphisms with diabetic polyneuropathy in patients with diabetes mellitus type 1].
Single-nucleotide polymorphisms of the genes for mitochondrial (SOD2) and extracellular (SOD3) superoxide dismutases were tested for association with diabetic polyneuropathy (DPN) in diabetes mellitus (DM) type 1. Patients (n = 180) were divided into two groups with nonoverlapping (polar) phenotypes. Group DPN+ included 86 individuals with DPN and DM type 1 record of no more than 5 years. Group DPN-included 94 patients with DM type 1 record of more than 10 years but without clinical signs of DPN. Fisher's exact test revealed significant differences in allele and genotype frequencies for the two groups. Higher frequencies of SOD2 allele Val and genotype Val/Val and of SOD3 allele Arg and genotype Arg/Arg were established for group DPN+. On this evidence, SOD2 and SOD3 were associated with DPN in DM type 1.
Zotova
E V
EV
State Research Center GosNIIgenetika, Moscow, 117545 Russia.
Chistiakov
D A
DA
Savost'ianov
K V
KV
Bursa
T R
TR
Galeev
I V
IV
Strokov
I A
IA
Nosikov
V V
VV
D000293:Adolescent; D000328:Adult; D000409:Alanine / Q000235:genetics; D001120:Arginine / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000235:genetics*; D003929:Diabetic Neuropathies / Q000209:etiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005998:Glycine / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D013482:Superoxide Dismutase / Q000235:genetics*; D014633:Valine / Q000235:genetics; D000099156:Superoxide Dismutase 2
D000409:Alanine; D001120:Arginine; D005998:Glycine; D013482:Superoxide Dismutase; D014633:Valine; D000099156:Superoxide Dismutase 2; C441642:SOD3 protein, human