title: Regulation of peripheral T-cell homeostasis by receptor signalling.
abstract: The peripheral T-cell pool is maintained at a constant size throughout life. This is achieved through tight homeostatic regulation of the different T-cell subsets. T cells appear to be able to sense whether the T-cell compartment is full and, if it is not, they are able to respond by undergoing cell division. Recent advances have identified that both signalling through the T-cell receptor and a variety of cytokines are essential for the regulation of these responses.
authors.affiliation: Department of Molecular Immunology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. bseddon@nimr.mrc.ac.uk
authors.forename: Benedict
authors.initials: B
authors.lastname: Seddon
authors.forename: Rose
authors.initials: R
authors.lastname: Zamoyska
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D006706:Homeostasis; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D016207:Cytokines; D011948:Receptors, Antigen, T-Cell