Direct and cross-protective effects of heat adaptation in cultured cells.
The model of 6-day dosed heat adaptation was developed on cultured rat H9c2 cardiomyoblasts and mouse C2c12 myoblasts. Heat adaptation produced a direct protective effect and increased the resistance of cells to heat shock. The cross-protective effect of heat adaptation was manifested in an increase in the resistance to staurosporine-induced damage. Heat adaptation did not protect cells from oxidative damage. As differentiated from adaptation of the organism, heat adaptation produces direct and cross-protective effects that develop due to the action of environmental factors in the absence of neurohumoral agents. It should be emphasized that the cross-protective effect of heat adaptation in cultured cells is specific to a certain type of damage.
Monastyrskaya
E A
EA
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Andreeva
L V
LV
Duchen
M R
MR
Manukhina
E B
EB
Malyshev
I Yu
IY
D000064:Acclimatization; D000818:Animals; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000378:metabolism; D006358:Hot Temperature; D051379:Mice; D032446:Myoblasts / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism*; D018384:Oxidative Stress; D051381:Rats; D019311:Staurosporine / Q000378:metabolism
D004791:Enzyme Inhibitors; D019311:Staurosporine