In vitro trypanocidal activity of triterpenes from miconia species.
The bioassay-guided fractionation of methylene chloride extracts of Miconia fallax DC. and Miconia stenostachya DC. led to the isolation of five triterpene acids. The triterpenes ursolic acid, oleanolic acid and gypsogenic acid were active against blood trypomastigote forms of Trypanosoma cruzi. In contrast, the acetyl and methyl ester derivatives were not found to potentiate the trypanocidal activity. These results suggest the importance of the polar groups for activity.
Cunha
Wilson Roberto
WR
Martins
Camila
C
da Silva Ferreira
Daniele
D
Crotti
Antonio Eduardo Miller
AE
Lopes
Norberto Peporine
NP
Albuquerque
Sérgio
S
D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy; D006801:Humans; D035322:Melastomataceae; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects*
D010936:Plant Extracts; D014315:Triterpenes; D014344:Trypanocidal Agents