Comparative trial between sodium tetradecyl sulfate and glycerin in the treatment of telangiectatic leg veins.
BACKGROUND
Thirteen patients were treated with either sodium tetradecyl sulfate (STS) or glycerin to compare the efficacy and adverse sequelae of each agent.


OBJECTIVE
To determine the relative safety and efficacy of two sclerosant solutions.


METHODS
Each patient's leg veins that were from 0.2 to 0.4 mm in diameter and that did not have incompetence from the saphenofemoral junction and whose feeding reticular veins had been already treated in a prior sclerotherapy session were randomly treated with either 0.25% STS or 72% glycerin solution. Patients were evaluated from 2 to 6 months postsclerotherapy for overall clinical improvement and incidence of adverse sequelae.


RESULTS
Glycerin was comparable to STS in discomfort of injection but demonstrated a significant decrease in bruising, swelling, and postprocedural hyperpigmentation. Glycerin also demonstrated a better, more rapid clearance of treated telangiectasias.


CONCLUSIONS
Seventy-two percent glycerin is a safe and effective sclerosant with fewer side effects and more rapid clearance of telangiectatic leg veins than STS.
Leach
Brian C
BC
Dermatology/Cosmetic Laser Associates of La Jolla, Inc., La Jolla, California 92037, USA.
Goldman
Mitchel P
MP
D000328:Adult; D000368:Aged; D003451:Cryoprotective Agents / Q000008:administration & dosage*; D005260:Female; D005990:Glycerol / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D008875:Middle Aged; D012597:Sclerosing Solutions / Q000008:administration & dosage*; D012981:Sodium Tetradecyl Sulfate / Q000008:administration & dosage*; D013684:Telangiectasis / Q000188:drug therapy*; D016896:Treatment Outcome; D014648:Varicose Veins / Q000188:drug therapy*
D003451:Cryoprotective Agents; D012597:Sclerosing Solutions; D005990:Glycerol; D012981:Sodium Tetradecyl Sulfate