title: Antioxidant activity of Baccharis articulata extracts: isolation of a new compound with antioxidant activity.
abstract: Baccharis articulata is traditionally used as diuretic and digestive in local folk medicine of south of Brazil, Uruguay and Argentina. The antioxidant activity of crude ethanol and aqueous extracts, together with ethyl acetate and n-butanol fractions obtained from aqueous extract of B. articulata was determined using TRAP and TBARS assays. The n-butanol fraction was found to be the most active and its major compound (BaII) was isolated, identified and assayed. The structure of the phenolic compound BaII was established by means of spectroscopic and chemical methods as 4'-O-beta-D-glucopyranosyl-3',5'-dimethoxybenzyl-caffeate. This previously unreported metabolite presented similar antioxidant capacity when compared to Trolox.
authors.affiliation: Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Ipiranga, 2752, Porto Alegre, RS, 90610-000, Brazil.
authors.forename: Simone Q
authors.initials: SQ
authors.lastname: De Oliveira
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
authors.forename: Grace
authors.initials: G
authors.lastname: Gosmann
authors.forename: Dominique
authors.initials: D
authors.lastname: Guillaume
authors.forename: José Cláudio F
authors.initials: JC
authors.lastname: Moreira
authors.forename: Eloir P
authors.initials: EP
authors.lastname: Schenkel
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D031175:Baccharis / Q000737:chemistry*; D002839:Chromans / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D012708:Sertoli Cells / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D012717:Sesquiterpenes / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013997:Time Factors
chemical_list: D000975:Antioxidants; D002839:Chromans; D005609:Free Radicals; D010936:Plant Extracts; D012717:Sesquiterpenes; D017392:Thiobarbituric Acid Reactive Substances; C013828:baileyolin; D006861:Hydrogen Peroxide; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid