Brugia malayi: establishment in inbred and outbred strains of mice.
Immunocompetent mouse model for human filarial parasite Brugia malayi is urgently required in view of the paucity of commercial reagents for other susceptible rodent viz. mastomys and gerbil. Genes within the major histocompatibility complex have been reported to influence the susceptibility of mouse to helminth parasites. Attempts have therefore been made in the present investigation to experimentally infect various inbred strains of mice viz. NZB/BINJ, BALB/c, AKR, C(3)H, and SJL/J with H-2 haplotype (H-2: d, d, k, k, s, respectively) and outbred strains of mice viz. Parks and Swiss. Findings indicate that susceptibility of mice to B. malayi is strain associated. This is the first report on the successful completion of full developmental cycle of subperiodic B. malayi in NZB/BINJ, an immunocompetent mouse strain. In some of the other strains, partial development or low degree of establishment of worms was observed.
Gupta
Ruma
R
Division of Parasitology, Central Drug Research Institute, P.O. Box 173, 226001, Lucknow, India.
Tyagi
Kumkum
K
Jain
S K
SK
Misra-Bhattacharya
Shailja
S
D000818:Animals; D017178:Brugia malayi / Q000254:growth & development / Q000276:immunology* / Q000302:isolation & purification; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D005260:Female; D005368:Filariasis / Q000276:immunology*; D006183:H-2 Antigens / Q000235:genetics; D006239:Haplotypes; D006321:Heart / Q000469:parasitology; D007121:Immunocompetence; D007814:Larva / Q000254:growth & development; D008168:Lung / Q000469:parasitology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains
D006183:H-2 Antigens