New 1-C-(5-thio-D-xylopyranosyl) derivatives as potential orally active venous antithrombotics.
In the search for new orally active antithrombotic drugs that are metabolically stable, we explored the synthesis of 1-C-(5-thio-D-xylosyl) derivatives, examining radical and nucleophilic methods. Thus synthesized were aryl, benzyl, alkylcarboxymethylenyl, arylsulfonylmethylenyl and alkylaminocarboxymethylenyl C-linked analogues of 5-thio-D-xylopyranosides.
Mignon
Laurent
L
Laboratoires Fournier, 50 rue de Dijon, 21121, Daix, France.
Goichot
Christophe
C
Ratel
Philippe
P
Cagnin
Gérald
G
Baudry
Michel
M
Praly
Jean-Pierre
JP
Boubia
Benaïssa
B
Barberousse
Véronique
V
D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D008956:Models, Chemical; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship; D013865:Thioglycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D013927:Thrombosis / Q000188:drug therapy; D014994:Xylose / Q000737:chemistry*
D005343:Fibrinolytic Agents; D013865:Thioglycosides; D014994:Xylose