Cadherin expression in the inner ear of developing zebrafish.
Cadherins are cell adhesion molecules that have been implicated in development of a variety of organs including the ear. In this study we analyzed expression patterns of three zebrafish cadherins (Cadherin-2, -4, and -11) in the embryonic and larval zebrafish inner ear using both in situ hybridization and immunocytochemical methods. All three Cadherins exhibit distinct spatiotemporal patterns of expression during otic vesicle morphogenesis. Cadherin-2 and Cadherin-4 proteins and their respective mRNAs were detected mainly in the sensory patches and the statoacoustic ganglion (SAg), respectively. In contrast, cadherin-11mRNA was widely expressed earlier in the otic placode, and later became restricted to a subset of cells in the inner ear, including hair cells.
Novince
Z M
ZM
Department of Biology, University of Akron, Akron, OH 44325-3908, USA.
Azodi
E
E
Marrs
J A
JA
Raymond
P A
PA
Liu
Q
Q
D000818:Animals; D015820:Cadherins / Q000096:biosynthesis / Q000235:genetics*; D007758:Ear, Inner / Q000196:embryology / Q000378:metabolism*; D020869:Gene Expression Profiling; D017403:In Situ Hybridization; D012333:RNA, Messenger / Q000378:metabolism; D015027:Zebrafish / Q000196:embryology / Q000378:metabolism*
D015820:Cadherins; D012333:RNA, Messenger