title: Indoor air quality and health does fungal contamination play a significant role?
abstract: Fungal contamination in buildings can vary greatly, and their presence in a dwelling does not necessarily constitute exposure. Measurement of mold spores and fragments varies depending on the methodology and instruments used. Meaningful comparison of data is rarely possible. The presence of a specific immune response to a fungal antigen only connotes that exposure to one or more related species has occurred, but not that there is a symptomatic clinical state. The response of individuals to indoor bioaerosols is complex and depends on age, gender, state of health, genetic makeup, and degree and time of bioaerosol exposure. In general, mold contamination in buildings is associated with incursion of water or moisture, which should be remedied as efficiently as possible. When disease occurs, it more likely is related to transient annoyance or irritational reactions. Allergic symptoms may be related to mold proliferation in the home environment. Because molds are encountered both indoors and outdoors, it is difficult to determine where the sensitivity initially arose and if the response is solely provoked by either an indoor or outdoor source. As an indoor allergen, mold is considered to be an infrequent participant in the induction of allergic disease when compared with housedust mites, animal dander, and cockroach allergens. Infection in healthy individuals is rare and usually is caused by an outdoor source. Building-related disease caused by mycotoxicosis has not been proved in the medical literature.
authors.affiliation: Division of Allergy and Clinical Immunology, Department of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, OP34, Portland, OR 97239, USA. bardanae@ohsu.edu
authors.forename: Emil J
authors.initials: EJ
authors.lastname: Bardana
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects*; D005658:Fungi / Q000276:immunology* / Q000472:pathogenicity*; D006262:Health; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000382:microbiology; D008171:Lung Diseases / Q000276:immunology* / Q000382:microbiology; D013191:Stachybotrys / Q000276:immunology / Q000472:pathogenicity*