Effect of vitamin C, E-acetate and beta-carotene on the cytostatic activity of nicotinamide (vitamin B3).
From experiments in vitro (E. coli bacteria AB 1157) it was established that the cytostatic activity of nicotinamide (vitamin B3) in aqueous, aerated media (pH = 7.4) under irradiation with gamma-rays can be strongly enhanced in the presence of antioxidant vitamins. Whereas the addition of beta-carotene (beta-car) increases nicotinamide activity by a factor of 1.7, vitamin E (vit.E) of 2.16 and vitamin C (vit.C) of 2.3, in the presence of all three vitamins (beta-car, vit.E and C) a four times enhancement is observed. This ability of the vitamins to affect so strongly the cytostatic properties of nicotinamide is of interest for the radiation therapy of patients.
Getoff
Nikola
N
Ludwig Boltzmann Institute for Radiation Chemistry and Radiation Biology, University of Vienna, Althanstr. 14, A-1090 Wien, Austria.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000528:radiation effects; D005720:Gamma Rays; D009536:Niacinamide / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology; D024505:Tocopherols; D024502:alpha-Tocopherol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D019207:beta Carotene / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D011838:Radiation-Sensitizing Agents; D019207:beta Carotene; D009536:Niacinamide; D024502:alpha-Tocopherol; D001205:Ascorbic Acid; D024505:Tocopherols