title: Shifts in cellular localization of moesin in normal oral epithelium, oral epithelial dysplasia, verrucous carcinoma and oral squamous cell carcinoma.
abstract: BACKGROUND
  Moesin, a member of ERM (ezrin/radixin/moesin) family, links actin filaments of cell surface structure to the cell membrane. The purpose of the study is to assess the shifts in cellular distribution of moesin in normal oral epithelium, oral epithelial dysplasia (OED), verrucous carcinoma (VC), and oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  The expression of moesin was evaluated immunohistochemically in paraffin-embedded tissues of 59 specimens of OSCC, 35 specimens of OED, 17 specimens of VC, and five specimens of normal oral epithelium.
  
  
  RESULTS
  In the normal oral epithelia, all specimens showed a pattern of membranous expression against the anti-moesin antibody in the basal layer cells. In the OED specimens, moesin was dominantly expressed in the cell membrane except for the cornified layer. In VC and OSCC specimens, almost the whole of the carcinoma cells were stained with anti-moesin antibody. However, in OSCC samples, moesin was markedly expressed increasingly in the cytoplasm and decreasingly in the cell membrane, as compared with OED and VC. In addition, there was a significant correlation between the pattern of moesin expression and tumor differentiation in OSCC.
  
  
  CONCLUSIONS
  Our results suggest that it is useful to detect the moesin expression as adjunct to screening mucosal lesions in the oral cavity.
authors.affiliation: Department of Dentistry and Oral Surgery, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Asahi 3-11, Matsumoto 390-8621, Japan. h-koba@hsp.md.shinshu-u.ac.jp
authors.forename: Hiroichi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Junji
authors.initials: J
authors.lastname: Sagara
authors.forename: Junya
authors.initials: J
authors.lastname: Masumoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kurita
authors.forename: Kenji
authors.initials: K
authors.lastname: Kurashina
authors.forename: Shuníichiro
authors.initials: S
authors.lastname: Taniguchi
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000378:metabolism*; D018289:Carcinoma, Verrucous / Q000737:chemistry / Q000378:metabolism*; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D003593:Cytoplasm / Q000737:chemistry / Q000378:metabolism; D004847:Epithelial Cells / Q000737:chemistry; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008840:Microfilament Proteins / Q000032:analysis* / Q000096:biosynthesis*; D008875:Middle Aged; D009061:Mouth Mucosa / Q000737:chemistry / Q000378:metabolism*; D009062:Mouth Neoplasms / Q000737:chemistry / Q000378:metabolism*; D011230:Precancerous Conditions / Q000737:chemistry / Q000378:metabolism*; D018709:Statistics, Nonparametric
chemical_list: D000911:Antibodies, Monoclonal; D008840:Microfilament Proteins; C071058:moesin