title: Successful treatment of natural killer (NK) cell leukemia following a long-standing chronic active Epstein-Barr virus (CAEBV) infection with allogeneic bone marrow transplantation.
abstract: The optimal treatment for natural killer (NK) cell leukemia after chronic active Epstein-Barr virus (CAEBV) infection has not been determined. A 15-year-old boy presented with NK cell leukemia following CAEBV infection for 5 years. The peripheral blood and BM had an increased number of CD3(-)CD56(+) large granular lymphocytes and a monoclonal integration of the EBV genome was detected. Chemotherapy was not sufficiently effective to control the disease. Allogeneic BMT from an HLA-identical sister was performed using a conditioning regimen consisting of total body irradiation, cyclophosphamide and thiotepa. The patient is disease-free with a perfect performance status 24 months after BMT. This is the first report to show that allogeneic BMT is potentially able to cure NK cell leukemia after CAEBV infection.
authors.affiliation: Department of Pediatric Hematology/Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ebihara
authors.forename: A
authors.initials: A
authors.lastname: Manabe
authors.forename: R
authors.initials: R
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Yoshimasu
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa
authors.forename: T
authors.initials: T
authors.lastname: Iseki
authors.forename: J
authors.initials: J
authors.lastname: Hayakawa
authors.forename: M
authors.initials: M
authors.lastname: Maeda
authors.forename: S
authors.initials: S
authors.lastname: Asano
authors.forename: K
authors.initials: K
authors.lastname: Tsuji
mesh_terms: D000293:Adolescent; D016026:Bone Marrow Transplantation; D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007694:Killer Cells, Natural / Q000821:virology; D007945:Leukemia, Lymphoid / Q000209:etiology* / Q000628:therapy* / Q000821:virology; D008297:Male; D014184:Transplantation, Homologous; D016662:Virus Integration
chemical_list: D004279:DNA, Viral