The molecular basis of the antigenic cross-reactivity between measles and cowpea mosaic viruses.
Two nonrelated viruses, cowpea mosaic virus (wtCPMV) and measles virus (MV), were found to induce cross-reactive antibodies. The nature of this cross-reactivity was studied and results are presented here demonstrating that antiserum raised against wtCPMV reacted with peptide from the fusion (F) protein of MV. Furthermore, the F protein of MV was shown to share an identical conformational B cell epitope with the small subunit of CPMV coat protein. Passive transfer of anti-wtCPMV antibodies into BALB/c mice conferred partial protection against measles virus induced encephalitis. The results are discussed in the context of cross-protection.
Olszewska
Wieslawa
W
Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. w.olszewska@imperial.ac.uk
Steward
Michael W
MW
D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D036022:Capsid Proteins / Q000737:chemistry / Q000276:immunology; D017798:Comovirus / Q000276:immunology*; D003429:Cross Reactions; D018792:Encephalitis, Viral / Q000517:prevention & control; D005260:Female; D007106:Immune Sera / Q000276:immunology; D007116:Immunization, Passive; D008459:Measles virus / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D011817:Rabbits; D017385:Sequence Homology; D014760:Viral Fusion Proteins / Q000737:chemistry / Q000276:immunology
D000914:Antibodies, Viral; D036022:Capsid Proteins; D007106:Immune Sera; D014760:Viral Fusion Proteins