[Hormonal-metabolic status of cancer patients with late-onset menopause].
Late-onset of menopause is a marker of risk factor for neoplasia in the reproductive system and, conversely, anti-risk for certain non-infectious diseases, such as cardio-vascular disease or osteoporosis. We studied 118 postmenopausal patients with early endometrial and breast cancers. The investigation was particularly concerned with hormonal-metabolic status versus age at menopause age at. While a Quetelet index/age was irrelevant, blood cholesterol and insulin (120 min) concentrations and tumor estrogen/progesterone receptor ratios were relatively higher in the late-onset group ((52 yrs). This group showed a correlation with age at menopause while the other one--with its duration. Insulin/body weight ratios were higher in the late-onset group while LH/FSH--lower. Hence, patients of the same age but differing in age at menopause age at may show differences in hormonal-metabolic status as well. This feature may be significant in identifying both biological distinctions of associated tumors and their clinical course.
Bershteĭn
D M
DM
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Chernobrovkina
A E
AE
Gamaiunova
V B
VB
Tsyrlina
E V
EV
Kvachevskaia
Iu O
IuO
Kovalenko
I G
IG
D017668:Age of Onset; D002784:Cholesterol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008593:Menopause / Q000097:blood*; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000209:etiology* / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000097:blood; D011980:Receptors, Progesterone / Q000097:blood; D012307:Risk Factors
D006728:Hormones; D007328:Insulin; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002784:Cholesterol