title: Functional magnetic resonance imaging: a review of methodological aspects and clinical applications.
abstract: This paper gives an overview of the recent literature on methodological developments of functional magnetic resonance imaging (fMRI) and recent trends in clinical applications. With the recent introduction of high-field systems and methodological developments leading to more robust signal behavior, fMRI is in a transition state from a research modality for use by experts to a standard procedure with useful applications in patient management. Compared to the use in neuroscientific research, which is often based on BOLD techniques alone, the application in patients is distinguished by a multiparametric characterization of the brain using a combination of several techniques. Neuronal fiber tracking based on diffusion anisotropy measurements, in particular, has already turned out to provide relevant supplementary information to the BOLD-based cortical activation maps.
authors.affiliation: Abt. Röntgendiagnostik, Section of Medical Physics, Freiburg, Germany. hennig@nz11.ukl.uni-freiburg.de
authors.forename: Jürgen
authors.initials: J
authors.lastname: Hennig
authors.forename: Oliver
authors.initials: O
authors.lastname: Speck
authors.forename: Martin A
authors.initials: MA
authors.lastname: Koch
authors.forename: Cornelius
authors.initials: C
authors.lastname: Weiller
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000473:pathology / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*