Nanog: a new recruit to the embryonic stem cell orchestra.
In this issue of Cell, and add a new transcriptional operating system to the known Oct4 and Stat3 systems required for early embryonal stem cell potency and self-renewal. Nanog, a homeobox transcription factor, plays a crucial role in the second embryonic cell fate specification following formation of the blastocyst.
Cavaleri
Fatima
F
University of Pennsylvania, School of Veterinary Medicine, Center for Animal Transgenesis and Germ Cell Research, New Bolton Center, 382 West Street Road, Kennett Square, PA 19348, USA.
Schöler
Hans R
HR
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D019070:Cell Lineage / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004622:Embryo, Mammalian / Q000196:embryology / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics* / Q000302:isolation & purification; D051379:Mice; D050814:Octamer Transcription Factor-3; D050796:STAT3 Transcription Factor; D039901:Totipotent Stem Cells / Q000378:metabolism*; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000302:isolation & purification
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D050814:Octamer Transcription Factor-3; C494174:Pou5f1 protein, mouse; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors