Cholecystokinin antagonists: pharmacological and therapeutic potential.
Cholecystokinin (CCK) is a regulatory peptide hormone, predominantly found in the gastrointestinal tract, and a neurotransmitter present throughout the nervous system. In the gastrointestinal system CCK regulates motility, pancreatic enzyme secretion, gastric emptying, and gastric acid secretion. In the nervous system CCK is involved in anxiogenesis, satiety, nociception, and memory and learning processes. Moreover, CCK interacts with other neurotransmitters in some areas of the CNS. The biological effects of CCK are mediated by two specific G protein coupled receptor subtypes, termed CCK(1) and CCK(2). Over the past fifteen years the search of CCK receptor ligands has evolved from the initial CCK structure derived peptides towards peptidomimetic or non-peptide agonists and antagonists with improved pharmacokinetic profile. This research has provided a broad assortment of potent and selective CCK(1) and CCK(2) antagonists of diverse chemical structure. These antagonists have been discovered through optimization programs of lead compounds which were designed based on the structures of the C-terminal tetrapeptide, CCK-4, or the non-peptide natural compound, asperlicin, or derived from random screening programs. This review covers the main pharmacological and therapeutic aspects of these CCK(1) and CCK(2) antagonist. CCK(1) antagonists might have therapeutic potential for the treatment of pancreatic disorders and as prokinetics for the treatment of gastroesophageal reflux disease, bowel disorders, and gastroparesis. On the other hand, CCK(2) antagonists might have application for the treatment of gastric acid secretion and anxiety disorders.
Herranz
Rosario
R
Instituto de Química Medica (CSIC), Juan de la Cierva 3, E-28006 Madrid, Spain. rosario@iqm.csic.es
D000595:Amino Acid Sequence; D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D005744:Gastric Acid / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000494:pharmacology* / Q000627:therapeutic use; D010455:Peptides / Q000737:chemistry; D017434:Protein Structure, Tertiary; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors / Q000737:chemistry; D013758:Tetragastrin / Q000378:metabolism
D008024:Ligands; D009479:Neuropeptides; D010455:Peptides; D011949:Receptors, Cholecystokinin; D013758:Tetragastrin; D002766:Cholecystokinin