Fully automated synthesis of O-(3-[18F]fluoropropyl)-L-tyrosine by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin.
A fully automated synthesis of O-(3-[18F]fluoropropyl)-L-tyrosine (FPT), an amino acid tracer for tumor imaging with positron emission tomography, is described. FPT was prepared by a two-step reaction sequence. Direct nucleophilic fluorination substitution of [18F]fluoride with 1,3-di(4-methylphenylsulfonyloxy)propane on a quaternary 4-(4-methylpiperidinyl)pyridinium functionalized polystyrene anion exchange resin, followed by [18F]fluoro-1-(4-methylphenylsulfonyloxy)propane yielded FPT. The overall radiochemical yield with no decay correction was about 12%; the whole synthesis time was about 52 min, and the radiochemical purity was above 95%.
Tang
Ganghua
G
Nanfang PET Centre, Nan Fang Hospital, First Military Medical University, Guangzhou 510515, China. tghtgh@china.com
Tang
Xiaolan
X
Wang
Mingfang
M
Luo
Lei
L
Gan
Manquan
M
D000837:Anion Exchange Resins / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging; D011726:Pyridinium Compounds / Q000737:chemistry*; D011786:Quality Control; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification; D012371:Robotics / Q000379:methods; D014055:Tomography, Emission-Computed / Q000379:methods; D014443:Tyrosine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification*
D000837:Anion Exchange Resins; C476802:O-(3-fluoropropyl)tyrosine; D011726:Pyridinium Compounds; D019275:Radiopharmaceuticals; D014443:Tyrosine