title: Intramuscular versus intradermal administration of anti-hepatitis B vaccine in non-cirrhotic hepatitis C patients.
abstract: Intradermal vaccination has been proposed as an alternative for the administration of anti-hepatitis B vaccine. Patients (n=66) with chronic viral hepatitis C without cirrhosis were randomised into two groups (intramuscular, n=38; and intradermal, n=28) for prospective immunisation with 20 microg recombinant vaccine, using an ultra-rapid schedule (doses at 0, 15 and 30 days). Sero-conversion (antibody level >/=10 mU/ml) in the intramuscular group was reached by 20, 40 and 72% of patients at days 15, 30 and 60 compared to 4, 8 and 36% for the intradermal group (P=0.010 at day 60). Additionally, levels rose more rapidly in the intramuscular group (P=0.004). Our results do not support the use of intradermal route of immunisation against HBV in HCV patients.
authors.affiliation: Department of Gastroenterology, Hospital Ramón y Cajal, Ctra de Colmenar km 9.1, 28034 Madrid, Spain.
authors.forename: Eduardo Albéniz
authors.initials: EA
authors.lastname: Arbizu
authors.forename: Rafael Bárcena
authors.initials: RB
authors.lastname: Marugán
authors.forename: Javier Yuste
authors.initials: JY
authors.lastname: Grijalba
authors.forename: Pilar López
authors.initials: PL
authors.lastname: Serrano
authors.forename: Luis Gil
authors.initials: LG
authors.lastname: Grande
authors.forename: Santos
authors.initials: S
authors.lastname: Del Campo Terrón
mesh_terms: D005260:Female; D006509:Hepatitis B / Q000150:complications / Q000276:immunology / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000009:adverse effects; D019698:Hepatitis C, Chronic / Q000150:complications / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D007271:Injections, Intradermal; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D014611:Vaccination
chemical_list: D017325:Hepatitis B Vaccines