Local expression of cytokine genes in uterine adnexa and endometrium of women with pyoinflammatory adnexal diseases.
Changes in the local expression of IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-15, IL-18, TNF-alpha, IFN-gamma- and TGF-beta(2) genes in the uterine adnexa and endometrium were studied in women with pyoinflammatory adnexal diseases. Examination of tissue specimens from the uterine adnexa involved in inflammation revealed a direct correlation in the levels of mRNA production between IL-6 and IL-10 (r=0.93, p<0.1), IL-6 and IL-4 (r=0.96, p<0.01), IL-10 and IL-4 (r=0.91, p<0.01), IL-12 and IFN-gamma (r=0.98, p<0.01). Expression of IL-4 gene increased 5.1-fold (p=0.001), IL-6 2-fold (p=0.007), IL-8 90.2-fold (p=0.009), IL-10 2.9-fold (p=0.008), IL-12 2.3-fold (p=0.3), and TGF-beta(2) gene 10.3-fold (p=0.1). In the endometrium of women with pyoinflammatory adnexal diseases only IL-10 gene expression increased (15.6-fold, p=0.007).
Zhdanov
A V
AV
Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow.
Davydova
M P
MP
Kurbanova
D F
DF
Sosulina
L Yu
LY
Gabuniya
T G
TG
Van'ko
L V
LV
Sukhikh
G T
GT
D000290:Adnexa Uteri / Q000276:immunology / Q000502:physiology*; D000291:Adnexal Diseases / Q000235:genetics / Q000276:immunology*; D000328:Adult; D016207:Cytokines / Q000235:genetics* / Q000276:immunology; D004717:Endometrium / Q000276:immunology / Q000502:physiology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D016207:Cytokines