title: Moderate ischemic mitral regurgitation and coronary artery bypass surgery: effect of mitral repair on clinical outcome.
abstract: OBJECTIVE
  The optimal management of moderate (grade 2-3+) ischemic mitral regurgitation (MR) at the time of coronary artery bypass grafting (CABG) remains the subject of controversy. The study aim was to determine whether mitral repair associated with CABG is preferable to CABG alone in patients with moderate ischemic MR, in terms of intermediate outcome.
  
  
  METHODS
  Among 60 patients with moderate ischemic MR, 30 who underwent CABG plus mitral repair were compared with 30 others who underwent CABG alone. All patients underwent follow up echocardiographic and clinical examinations between 12 and 36 months after surgery. The decision to repair the valve during surgery was totally at the surgeons' discretion.
  
  
  RESULTS
  Preoperatively, both groups were substantially homogeneous. Patients who had CABG plus mitral repair had a lower NYHA functional class at intermediate follow up, and fewer signs and symptoms of heart failure. On multivariate analysis, mitral repair proved to be a protective factor for the development of heart failure. The preoperative size of the mitral annulus was seen to be a risk factor for subsequent heart failure events. At intermediate follow up, echocardiographic parameters were significantly better in the mitral repair group (left ventricular volume smaller, ejection fraction and pulmonary artery pressure improved).
  
  
  CONCLUSIONS
  The results of this case-control study showed that, in a homogeneous series of patients with moderate ischemic MR, repair of the mitral valve at the time of CABG leads to a better clinical status due to an improved hemodynamic profile.
authors.affiliation: San Donato Hospital, San Donato Milanese, Milan, Italy.
authors.forename: Marisa
authors.initials: M
authors.lastname: Di Donato
authors.forename: Alessandro
authors.initials: A
authors.lastname: Frigiola
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Menicanti
authors.forename: Ahmed
authors.initials: A
authors.lastname: Boghdabi
authors.forename: Toni
authors.initials: T
authors.lastname: Badia
authors.forename: Anna
authors.initials: A
authors.lastname: Neagu
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Montericcio
authors.forename: Marco
authors.initials: M
authors.lastname: Ranucci
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods*; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006334:Heart Function Tests; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000379:methods*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D011336:Probability; D012044:Regression Analysis; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome