The androgenic sex hormone profile is an essential feature of metabolic syndrome in premenopausal women: a controlled community-based study.
OBJECTIVE
To evaluate sex hormones in premenopausal white women with metabolic syndrome (MBS).


METHODS
Cross-sectional controlled community-based study.


METHODS
Pieksämäki District Health Center, Pieksämäki, Finland.


METHODS
Five hundred forty-three women, aged 34 to 54 years, were screened according to National Cholesterol Education Program criteria: waist >88 cm, hypertension >/=130/>/=85 mm Hg, hypertriglyceridemia >/=1.7 mmol/L, high-density lipoprotein (HDL)-cholesterol <1.3 mmol/L, and fasting glucose >/=6.1 mmol/L. Sixty-three women fulfilled at least three of the above-mentioned criteria and were enrolled. Eighty-eight age-matched women without MBS served as controls.


METHODS
None.


METHODS
Sex steroid levels in relation to insulin sensitivity and body composition.


RESULTS
A markedly lower insulin sensitivity index and higher free androgen index were detected in the women with MBS than in the controls. Abdominal obesity and increased diastolic blood pressure were significantly associated with high free androgen index in multiple regression analysis.


CONCLUSIONS
A hyperandrogenic hormone profile appeared to be a typical feature of premenopausal female MBS even without polycystic ovary syndrome (PCOS).
Korhonen
Seija
S
Department of Obstetrics and Gynecology, Mikkeli Central Hospital, Mikkeli, Finland.
Hippeläinen
Maritta
M
Vanhala
Mauno
M
Heinonen
Seppo
S
Niskanen
Leo
L
D000328:Adult; D000728:Androgens / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D008659:Metabolic Diseases / Q000097:blood*; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000097:blood; D017697:Premenopause / Q000097:blood*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis
D000728:Androgens; D012739:Gonadal Steroid Hormones; D012738:Sex Hormone-Binding Globulin