title: Enhanced functions of osteoblasts on nanostructured surfaces of carbon and alumina.
abstract: It is of the utmost importance to increase the activity of bone cells on the surface of materials used in the design of orthopaedic implants. Increased activity of such cells can promote either integration of these materials into surrounding bone or complete replacement with naturally produced bone if biodegradable materials are used. Osteoblasts are bone-producing cells and, for that reason, are the cells of interest in initial studies of new orthopaedic implants. If these cells are functioning normally, they lay down bone matrix onto both existing bone and prosthetic materials implanted into the body. It is generally accepted that a successful material should enhance osteoblast function, leading to more bone deposition and, consequently, increased strength of the interface between the material and juxtaposed bone. The present study provided the first evidence of greater osteoblast function on carbon and alumina formulations that mimic the nano-dimensional crystal geometry of hydroxyapatite found in bone.
authors.affiliation: Department of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Price
authors.forename: K M
authors.initials: KM
authors.lastname: Haberstroh
authors.forename: T J
authors.initials: TJ
authors.lastname: Webster
mesh_terms: D000537:Aluminum Oxide; D001672:Biocompatible Materials; D002244:Carbon; D000077482:Carbon Fiber; D002448:Cell Adhesion; D006801:Humans; D036103:Nanotechnology / Q000379:methods; D010006:Osteoblasts / Q000502:physiology*; D019736:Prostheses and Implants
chemical_list: D001672:Biocompatible Materials; D000077482:Carbon Fiber; D002244:Carbon; D000537:Aluminum Oxide