title: [Directed therapy in complex treatment of lower limb diabetic angiopathy].
abstract: Clinical efficiency of directed therapy was assessed for 312 patients with distal type of lower limb diabetic angiopathy. Methods of directed therapy included indirect electrochemical detoxication, hemosorption and their combination. It was shown that while successful rate of conventional conservative therapy does not exceed 50%, hemosorption and indirect electrochemical detoxication can increase this rate by 5-35%, depending on the initial severity of lower limb ischemia. Directed therapy improves peripheral circulation and attenuates regional toxemia. Optimal results were achieved for combination of hemosorption and indirect electrochemical detoxication: treatment was effective for 87% of patients with 2-grade disease and for 73% - with 3-grade. One can speculate that synergic clinical effect may be attributed to functional normalization of antioxidant system. In conclusion, advantages of directed therapy comparing with conventional conservative treatment lie in its higher efficiency and prolonged therapeutic effect.
authors.affiliation: Department of Hospital Surgery, Yaroslavl State Medical Academy, Russia.
authors.forename: N E
authors.initials: NE
authors.lastname: Rudnev
authors.forename: V V
authors.initials: VV
authors.lastname: Rybachkov
mesh_terms: D000368:Aged; D000975:Antioxidants; D003131:Combined Modality Therapy; D003925:Diabetic Angiopathies / Q000175:diagnosis / Q000628:therapy*; D004563:Electrochemistry; D005500:Follow-Up Studies; D006464:Hemoperfusion; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000628:therapy*; D007866:Leg / Q000098:blood supply*; D008875:Middle Aged; D016060:Sorption Detoxification; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants