Checkpoint mediators: relaying signals from DNA strand breaks.
The recently identified checkpoint mediator MDC1 facilitates recruitment of DNA repair proteins to damaged sites and establishment of the intra-S-phase cell-cycle checkpoint. Increasing evidence suggests that proteins like MDC1 provide the framework necessary for transducing signals from DNA double-strand breaks.
Canman
Christine E
CE
Pfizer Global Research & Development, 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA. christine.canman@pfizer.com
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D018797:Cell Cycle Proteins; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D018816:Genes, cdc / Q000502:physiology*; D006801:Humans; D008958:Models, Molecular; D009687:Nuclear Proteins / Q000502:physiology*; D015398:Signal Transduction; D015534:Trans-Activators / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; C413163:MDC1 protein, human; D009687:Nuclear Proteins; D015534:Trans-Activators