Ventilatory load compensation response to long-term chest compression in rat model.
Short-term chest compression has been shown to decrease tidal volume and increase respiratory frequency. The present study was designed to assess and characterize the effect of long-term chest compression on breathing pattern and blood gases in awake rats. Chest compression was carried out by inflating a pneumatic cuff placed around the chest to a pressure of 25 mmHg and the pressure was maintained for 28 days. Respiratory frequency increased progressively until 14 days after chest compression whereas a decrease in tidal volume was stabilized within 3 days after chest compression. Although the changes in minute ventilation were small and no substantial change in Pa(CO2) was observed, an impairment of weight gain and a decrease in body temperature with a concomitant hypoxemia were evident during sustained chest compression. These observations suggest that the ventilatory response to chest compression may involve not only neural reflex mechanisms but also other non-reflex mechanisms. Sustained chest compression possibly impairs growth and metabolism.
Iiyori
Nao
N
Department of Anesthesiology (B1), Graduate School of Medicine, Chiba University, Chiba, Japan. niiyori@aol.com
Ide
Tohru
T
Isono
Shiroh
S
Tagaito
Yugo
Y
Nishino
Takashi
T
D000818:Animals; D001784:Blood Gas Analysis / Q000379:methods; D001831:Body Temperature / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D003243:Consciousness / Q000502:physiology*; D004435:Eating / Q000502:physiology; D008297:Male; D023421:Models, Animal; D012123:Pulmonary Ventilation / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012121:Respiration, Artificial; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics / Q000502:physiology*; D012143:Respiratory Physiological Phenomena; D013997:Time Factors