Development of a Staphylococcus aureus vaccine against mastitis in dairy cows. II. Field trial.
A recently described new Staphylococcus aureus vaccine "MASTIVAC I" (Patent no. PTC/IL98/00627) against S. aureus udder infection elicited protection against experimentally induced infection in cows. In the present paper we describe a large-scale vaccination field trial. A total of 452 Israeli Holstein heifers were included in the study over two consecutive years. Approximately half of the heifers (228) were vaccinated while the others (224) served as a control group. Antibody response was detected in all vaccinated animals 4-5 weeks post-primary immunization and it was sustained throughout the experimental period (300-330 days). S. aureus infection could be detected in only 3 out of 228 animals (1.3%) in the vaccinated group and in 6 out of 224 (2.7%) in the control group. These numbers were too low to be statistically evaluated. However, when somatic cell counts (SCC) and milk yields were considered, a significant difference was found between the two groups, namely, the vaccinated cows in first and second lactation had 42 and 54%, respectively, lower SCCs and milk yields 0.5 kg per day higher than the non-vaccinated control cows. These results suggest that the new vaccine elicits a non-specific health improvement of the udder in addition to specific protection against S. aureus.
Leitner
Gabriel
G
National Mastitis Reference Center, Bet Dagon, Israel. gleit_vs@netvision.net.il
Yadlin
Nathan
N
Lubashevsy
Evgenia
E
Ezra
E
E
Glickman
Anita
A
Chaffer
Marcelo
M
Winkler
Marta
M
Saran
Arthur
A
Trainin
Zeev
Z
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D002417:Cattle; D005260:Female; D007774:Lactation; D008414:Mastitis, Bovine / Q000276:immunology*; D008892:Milk; D013203:Staphylococcal Infections / Q000276:immunology / Q000517:prevention & control* / Q000662:veterinary*; D013209:Staphylococcal Vaccines / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*
D000907:Antibodies, Bacterial; D013209:Staphylococcal Vaccines