title: [A gastric signet ring cell carcinoma as the first expression of a breast carcinoma].
abstract: A 73-year-old woman presented with dull pain in the epigastric region, a rapid feeling of fullness upon eating and a weight loss of 10 kg in 6 months. Further examination showed linitis plastica due to a signet ring cell carcinoma in the stomach, multiple bone metastases, and an occult, small breast tumour. Immunohistochemical comparison of the tumours strongly suggested that all cases involved a metastasised breast carcinoma. At check-up after one year of tamoxifen treatment, the complaints had disappeared and the activity of the tumour marker had dropped. Gastric metastases from breast carcinoma are rare. Nevertheless, this possibility should be kept in mind in women presenting with malignancies of the stomach and mastopathy. Hormonal treatment and chemotherapy may result in reasonable palliation.
authors.affiliation: Afd. Inwendige Geneeskunde, Onze Lieve Vrouwe Gasthuis Amsterdam. f_warmerdam@hotmail.com
authors.forename: F A R M
authors.initials: FA
authors.lastname: Warmerdam
authors.forename: J L G
authors.initials: JL
authors.lastname: Blaauwgeers
authors.forename: B
authors.initials: B
authors.lastname: de Valk
authors.forename: K J
authors.initials: KJ
authors.lastname: Roozendaal
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary*; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen