Prospective randomized comparison of 65%/65% versus 42%/42% tilt biphasic waveform on defibrillation thresholds in humans.
BACKGROUND
The waveform tilt of biphasic shocks yielding the lowest defibrillation threshold (DFT) is not well defined. Some evidence indicates that tilts less than 65% may improve DFTs.


METHODS
In 57 patients undergoing ICD implantation, DFTs were determined with truncated exponential biphasic waveform tilts at 65%/65% and at 42%/42%. An external defibrillator with custom software was used for testing. The effective capacitance of the defibrillator was 132-microF for both waveforms. DFTs were determined using a binary search method starting with 12 Joules (J). Patients were randomly assigned to initial testing with either one of the two tilts. Thirty patients (Group 1) were tested with a two electrode (active can to RV coil, or SVC coil to RV coil) and 27 patients (Group 2) were tested with a three electrode system (subcutaneous patch or active can + SVC coil to RV coil).


RESULTS
Groups 1 and 2 did not differ in age, ejection fraction or antiarrhythmic medications. Group 1 delivered energy DFTs were 10.1 +/- 5.5 J with the 65%/65% tilt and 10.1 +/- 5.9 J for the 42%/42% tilt (p = 0.92). In group 2 the average DFT for the 65%/65% tilt was 8.4 +/- 5.7 J and for the 42%/42% tilt was 8.1 +/- 5.3 J (p = 0.70). There were no significant differences in DFTs for either group. The system impedance for Group 1 was 64 +/- 12 ohms and for Group 2 was 39 +/- 6 ohms (p < 0.0001).


CONCLUSIONS
We found no differences in DFTs between 65%/65% tilt and 42%/42% tilt using either 2- or 3-electrode defibrillation systems. Further research is needed to optimize waveforms in order to minimize DFTs, which will result in smaller ICDs and/or greater safety margins for defibrillation.
Shepard
Richard K
RK
Department of Medicine, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA 23298-0053, USA.
DeGroot
Paul J
PJ
Pacifico
Antonio
A
Wood
Mark A
MA
Ellenbogen
Kenneth A
KA
D000368:Aged; D017147:Defibrillators, Implantable; D004554:Electric Countershock; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017180:Tachycardia, Ventricular / Q000628:therapy; D014693:Ventricular Fibrillation / Q000628:therapy*