title: 'On-line' alterations of contralateral jugular blood gas profile during carotid clamping.
abstract: The aim of this work was to record the metabolic status of the brain (pH, PCO(2) and PO(2)) during carotid endarterectomy (CEA), with the use of an intravascular multiparameter sensor (Paratrend 7) via retrograde catheterization of the contralateral jugular vein. Twenty-four patients with ASA grades II and III scheduled for CEA were included in the study. After induction of anesthesia, the contralateral internal jugular vein was punctured retrogradely and the sensor was introduced. During clamping, pH became persistently more acidotic (7.34-7.31; p < 0.05), PCO(2) was elevated (43.2-46.8 mm Hg; p < 0.05) while most of the patients showed a non-significant decrease in PjvO(2)/SjvO(2) (jv = jugular venous). Correlation with clamping time or stump pressure was not significant. Unclamping was followed by a short period (5- 9 min) of decrease in pH and elevation of PCO(2) (7.30-7.22; p < 0.05, and 48.0-52.5 mm Hg; p < 0.05, respectively). PjvO(2) was significantly elevated (51.8-58.0 mm Hg; p < 0.001) after the restoration of flow. The study suggests that local CO(2) creates conditions for compensation of flow after the application of a carotid clamp. We consider that this monitoring technique, after further validation, may provide useful information.
authors.affiliation: Department of Anesthesiology, Hospital 'G Gennimatas', 2nd Surgical Clinic of Aristotelian University of Thessaloniki, Hospital 'G Gennimatas', Thessaloniki, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Vretzakis
authors.forename: D
authors.initials: D
authors.lastname: Papadimitriou
authors.forename: B
authors.initials: B
authors.lastname: Papaziogas
authors.forename: S
authors.initials: S
authors.lastname: Koutsias
authors.forename: D
authors.initials: D
authors.lastname: Christopoulos
authors.forename: E
authors.initials: E
authors.lastname: Ferdi
authors.forename: G
authors.initials: G
authors.lastname: Papadopoulos
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis / Q000379:methods*; D002245:Carbon Dioxide / Q000097:blood; D002339:Carotid Arteries / Q000601:surgery*; D003324:Coronary Artery Disease / Q000097:blood / Q000601:surgery*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007601:Jugular Veins; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D010100:Oxygen / Q000097:blood; D013525:Surgical Instruments
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen