Evaluation of cancer therapy using diffusion magnetic resonance imaging.
Assessment of the effectiveness of cancer therapy traditionally relies on comparison of tumor images acquired before and after therapeutic intervention by inspection of gross anatomical images to evaluate changes in tumor size. The potential for imaging to provide additional insights related to the therapeutic impact would be enhanced if a specific parameter or combination of parameters could be identified that reflect tissue changes at the cellular or physiological level. This information could also provide a more sensitive and earlier indicator of treatment response in an individual animal or patient. Diffusion magnetic resonance imaging can detect relatively small changes in tissue structure at the cellular level and thus provides an opportunity to quantitatively and serially follow therapeutic-induced changes in solid tumors. This article provides an overview of the use of diffusion magnetic resonance imaging as a surrogate marker for quantitating treatment responsiveness in both preclinical and clinical studies.
Ross
Brian D
BD
University of Michigan Medical School, Ann Arbor, Michigan 48109-0648, USA.
Moffat
Bradford A
BA
Lawrence
Theodore S
TS
Mukherji
Suresh K
SK
Gebarski
Stephen S
SS
Quint
Douglas J
DJ
Johnson
Timothy D
TD
Junck
Larry
L
Robertson
Patricia L
PL
Muraszko
Karin M
KM
Dong
Qian
Q
Meyer
Charles R
CR
Bland
Peyton H
PH
McConville
Patrick
P
Geng
Hairong
H
Rehemtulla
Alnawaz
A
Chenevert
Thomas L
TL
D000818:Animals; D002986:Clinical Trials as Topic; D004058:Diffusion; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy*; D009374:Neoplasms, Experimental / Q000473:pathology / Q000628:therapy; D051381:Rats; D013997:Time Factors