Inhibitors of the NOS enzymes: a patent review.
This review covers the recent literature on inhibitors of nitric oxide synthase (NOS) between 2001 and June 2002. Some of the potential therapeutic uses of selective NOS inhibitors are highlighted in the introduction, while the main part of the review covers the patent literature of small molecule NOS inhibitors being investigated primarily by the pharmaceutical industry.
Mete
Antonio
A
AstraZeneca R&D Charnwood, Department of Medicinal Chemistry, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK. antonio.mete@astrazeneca.com
Connolly
Stephen
S
D000818:Animals; D004345:Drug Industry; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D010330:Patents as Topic
D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase