Effect of antibodies to morphine on synaptic plasticity of the hippocampus.
Incubation of hippocampal slices with antibodies to morphine did not change the total excitatory postsynaptic potential of mossy fibers, but markedly facilitated long-term posttetanic potentiation. Culturing of the organotypic hippocampal culture in the presence of 10 microM morphine increased the total excitatory postsynaptic potential of mossy fibers and reduced the probability of long-term posttetanic potentiation.
Beregovoi
N A
NA
Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. beka@cyber.ma.nsc.ru
Pankova
T M
TM
Sorokina
N S
NS
Starostina
M V
MV
D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000378:metabolism*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000502:physiology; D009020:Morphine / Q000276:immunology*; D009473:Neuronal Plasticity / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D000906:Antibodies; D009020:Morphine