title: Extracellular glutamate decrease in accumbens following cued food delivery.
abstract: This study examined the effects of cued vs non-cued food delivery/consumption on extracellular glutamate and dopamine in the nucleus accumbens of food-deprived rats. Animals that always received a food pellet following a series of auditory tones showed a significant decrease in extracellular glutamate following food consumption, whereas animals that had not been previously exposed to tone-food pairing did not (p<0.05). In contrast, extracellular dopamine was significantly increased in the nucleus accumbens during the first time period after food consumption (p<0.05) regardless of whether animals had been exposed to prior tone-food pairing. Results suggest that food delivery/consumption is associated with a decrease in accumbal glutamate if food delivery has been previously paired with predictive environmental cues.
authors.affiliation: Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Cellular and Clinical Neurobiology and Substance Abuse Division, USA.
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Chapman
authors.forename: John M
authors.initials: JM
authors.lastname: Roll
authors.forename: Samuel
authors.initials: S
authors.lastname: Park
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Galloway
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D003463:Cues; D004435:Eating / Q000502:physiology*; D005110:Extracellular Space / Q000378:metabolism*; D005508:Food Deprivation / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018698:Glutamic Acid