title: [Extranodal non-Hodgkin's lymphoma of MALT-type stage I. A case report].
abstract: BACKGROUND
  Extranodal non-Hodgkin's lymphoma are mostly localized in the gastrointestinal tract. A small number of these lymphoma arise from specialized lymphoid cells, the so-called mucosa-associated lymphoid tissue (MALT). We describe one case with a metachronous occurrence of a MALT-type lymphoma of the conjunctiva of both eyelids and supraglottic larynx.
  
  
  METHODS
  A 56-year old woman was first treated in August 1990 for a low-grade B-cell lymphoma in the conjunctiva of the left eyelid. 42 months later an extranodal B-cell lymphoma, located in the conjunctiva of the right eyelid, was found. After a father period of 48 months a MALT-type lymphoma arose in the supraglottic larynx. The findings of staging examinations were normal. The final diagnosis was low-grade B-cell lymphoma of the MALT-type, limited to the conjunctival eyelids and supraglottic larynx, with the clinical staging of IE A. Treatment consisted of a LASER-resection followed by a locoregional radiotherapy, with the dose of 40 Gy.
  
  
  RESULTS
  Currently no evidence of disease (NED) at all sites can be proven.
  
  
  CONCLUSIONS
  Extranodal, primary low grade B-cell MALT-type lymphoma are rare. In the literature only few cases of each larynx- and conjunctival eyelid involvement described. The radiotherapy has been reported to achieve a long time of relapse-free interval. The present case demonstrates, that even the recurrence of an extranodal, primary low-grade B-cell MALT-type lymphoma responds well to local radiotherapy and can also have a long period of no evidence of disease.
authors.affiliation: Klinik für Strahlentherapie, Martin-Luther-Universität Halle-Wittenberg, Halle/Salle, Germany. thomas.kuhnt@medizin.uni-halle.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Kuhnt
authors.forename: Bettina
authors.initials: B
authors.lastname: Wollschläger
authors.forename: Marc
authors.initials: M
authors.lastname: Bloching
authors.forename: Ulf
authors.initials: U
authors.lastname: Krause
authors.forename: Jürgen
authors.initials: J
authors.lastname: Dunst
mesh_terms: D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D053685:Laser Therapy; D018442:Lymphoma, B-Cell, Marginal Zone / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D008875:Middle Aged; D009367:Neoplasm Staging; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome