title: Tolerance: of mice and men.
abstract: Little is known about the effect of an individual's immune history on his or her response to an allogeneic tissue transplant. An important study now reveals that individuals harboring virally-induced memory T cells that are cross reactive with donor alloantigen are resistant to conventional strategies designed to induce transplant tolerance.
authors.affiliation: Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts 02129, USA. sachs@helix.mgh.harvard.edu
authors.forename: David H
authors.initials: DH
authors.lastname: Sachs
mesh_terms: D000818:Animals; D000941:Antigens; D003429:Cross Reactions; D006801:Humans; D007108:Immune Tolerance; D007156:Immunologic Memory; D051379:Mice; D011323:Primates; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
chemical_list: D000941:Antigens