Sex differences in interest in infants in juvenile rhesus monkeys: relationship to prenatal androgen.
Yearling rhesus monkey females interact more with infants than do males. However, the continuity of this sex difference throughout the juvenile period is unknown. Human females display similar sexually differentiated interest in infants, and studies of girls with congenital adrenal hyperplasia suggest that this sex difference may be modulated by prenatal androgen exposure. We investigated infant interest in 1- to 3-year-old juvenile rhesus monkeys. Hormonal influences on this behavior were investigated by treating pregnant females with an androgen-receptor blocker (flutamide), testosterone enanthate, or vehicle, early or late in gestation. Subjects were reared in their well-established natal groups, composed of species-typical matrilineal social structures, including members of all ages. Yearling control females interacted with infants more than did yearling control males. At 2 and 3 years of age, the magnitude of the sex difference in interactions with infants increased markedly, producing effect sizes of more than 2.5 standard deviations. These effects are larger than those reported in humans. Androgen treatment did not affect male or female interactions with infants, but late gestation flutamide masculinized aspects of females' interest in infants. Although early flutamide prevented complete masculinization of male genitalia, this treatment was not accompanied by any alterations in the masculine pattern of infant interest. We found no evidence that the robust juvenile sex difference in frequency of infant interactions results from socialization. However, it was largely unaffected by our hormone manipulations. Whether this reflects characteristics of our specific treatments or is evidence of nonhormonal influences on infant interest remains unanswered.
Herman
Rebecca A
RA
Department of Psychology and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA. rherman@emory.edu
Measday
Megan A
MA
Wallen
Kim
K
D000367:Age Factors; D000704:Analysis of Variance; D000726:Androgen Antagonists / Q000008:administration & dosage; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D005260:Female; D005485:Flutamide / Q000008:administration & dosage; D008253:Macaca mulatta / Q000502:physiology* / Q000523:psychology; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012727:Sex Characteristics; D012737:Sex Factors; D012919:Social Behavior; D013739:Testosterone / Q000008:administration & dosage / Q000502:physiology*
D000726:Androgen Antagonists; D013739:Testosterone; D005485:Flutamide