title: Cell cycle and apoptosis.
abstract: Apoptosis and proliferation are intimately coupled. Some cell cycle regulators can influence both cell division and programmed cell death. The linkage of cell cycle and apoptosis has been recognized for c-Myc, p53, pRb, Ras, PKA, PKC, Bcl-2, NF-kappa B, CDK, cyclins and CKI. This review summarizes the different functions of the proteins presently known to control both apoptosis and cell cycle progression. These proteins can influence apoptosis or proliferation but different variables, including cell type, cellular environment and genetic background, make it difficult to predict the outcome of cell proliferation, cell cycle arrest or cell death. These important decisions of cell proliferation or cell death are likely to be controlled by more than one signal and are necessary to ensure a proper cellular response.
authors.affiliation: Faculty of Medicine, Laboratory of Experimental Hematology, University of Antwerp, Antwerp University Hospital, Edegem, Belgium.
authors.forename: Katrien
authors.initials: K
authors.lastname: Vermeulen
authors.forename: Zwi N
authors.initials: ZN
authors.lastname: Berneman
authors.forename: Dirk R
authors.initials: DR
authors.lastname: Van Bockstaele
mesh_terms: D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology; D002455:Cell Division; D016213:Cyclins / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009857:Oncogenes; D010770:Phosphotransferases / Q000378:metabolism
chemical_list: D018797:Cell Cycle Proteins; D016213:Cyclins; D010770:Phosphotransferases