title: Can presence or absence of periodontal pathogens distinguish between subjects with chronic and aggressive periodontitis? A systematic review.
abstract: OBJECTIVE
  The purpose of this study was to determine to what extent the presence or absence of periodontal pathogens can distinguish between subjects with chronic and aggressive periodontitis.
  
  
  METHODS
  A systematic review of cross sectional and longitudinal studies providing microbiological data both from patients with chronic periodontitis (ChP) and aggressive periodontitis (AgP) at a subject level. Strict inclusion criteria were applied. The presence or absence of five microorganisms was selected as primary study parameters: Actinobacillus actinomycetemcomitans (AA), Porphyromonas gingivalis (PG), Prevotella intermedia (PI), Bacteroides forsythus (BF), and Campylobacter rectus (CR).
  
  
  RESULTS
  The presence or absence of AA could be evaluated in 11 papers. In seven papers the presence or absence of PG could be analysed. Subject specific data on PI were available from six studies. Two studies could be used regarding the presence or absence of BF, and two regarding CR. Sensitivity and specificity of every microbiological test were individually calculated for each selected study, assuming that the clinical diagnosis of AgP or ChP was the true status the tests attempted to detect. AgP was considered to be the condition of interest and ChP was considered equivalent to 'non-AgP'. Receiver Operator Characteristic (ROC) diagrams were constructed using these data. ROC diagrams indicated the limited discriminatory ability of all of the test parameters to identify subjects with AgP. An additional assessment showed that the highly leukotoxic variant of AA was uniquely associated with patients suffering from aggressive periodontitis. However, in a high proportion of patients diagnosed with AgP the presence of this variant could not be detected.
  
  
  CONCLUSIONS
  The presence or absence of AA, PG, PI, BF or CR could not discriminate between subjects with AgP from those with ChP.
authors.affiliation: School of Dental Medicine, University of Geneva, Switzerland. andrea.monbelli@medecine.unige.ch
authors.forename: Andrea
authors.initials: A
authors.lastname: Mombelli
authors.forename: Federico
authors.initials: F
authors.lastname: Casagni
authors.forename: Phoebus N
authors.initials: PN
authors.lastname: Madianos
mesh_terms: D000208:Acute Disease; D016976:Aggregatibacter actinomycetemcomitans / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D001439:Bacteroides / Q000302:isolation & purification; D002167:Campylobacter / Q000302:isolation & purification; D002908:Chronic Disease; D005098:Exotoxins / Q000235:genetics; D006801:Humans; D010518:Periodontitis / Q000145:classification* / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000302:isolation & purification; D018713:Prevotella intermedia / Q000302:isolation & purification; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D005098:Exotoxins; C018579:leukotoxin