Dynamics of chromatin, proteins, and bodies within the cell nucleus.
A new and still evolving paradigm of a highly dynamic nucleus has emerged in recent years. This paradigm includes an inherently high turnover rate of histone and non-histone protein modifications, targeted turnover and/or displacement of 'stable' core histone proteins, constant flux of macromolecules through chromosomes and nuclear bodies, including transcription factors and co-activators, and an energy-dependent facilitation of nuclear-protein complex formation and disassembly. Also included are fast, local movements of chromosomes, together with slower but long-range movements of chromosomes and nuclear bodies.
Belmont
Andrew
A
Department of Cell and Structural Biology, University of Illinois, Urbana-Champaign B107, Chemical and Life Science Laboratory, 601 South Goodwin Avenue, Urbana, IL 61801, USA. asbel@uiuc.edu
D002467:Cell Nucleus / Q000502:physiology*; D002843:Chromatin / Q000502:physiology*; D009687:Nuclear Proteins / Q000502:physiology*
D002843:Chromatin; D009687:Nuclear Proteins