title: Serum prolidase I activity and some bone metabolic markers in patients with breast cancer: in relation to menopausal status.
abstract: OBJECTIVE
  The purpose of this study was to investigate the diagnostic value of some osteoblastic/osteoclastic biochemical markers and serum prolidase I activity in breast cancer (BC).
  
  
  METHODS
  Serum bone gla protein (BGP), prolidase I activity, urinary deoxypyridinoline (Dpy) and calcium excretions were measured, in metastatic and nonmetastatic BC patients, and in 52 healthy women.
  
  
  RESULTS
  In patients with metastases, bone turnover markers were found to be significantly higher than those in the control group and in patients without metastases. Serum prolidase activity in patients with and without metastases was also significantly higher than those in the control group, but there was no difference between the two patient groups.
  
  
  CONCLUSIONS
  Bone turnover has been suggested to be accelerated in BC patients with the more pronounced osteolytic activation, especially in metastatic state. Serum prolidase in premenopausal period appears to be valuable in discriminating cancer patients from controls. BGP and to a lesser degree of Dpy, may be useful markers for predicting the metastatic bone involvement, as well as for the more cost effective management of BC patients and monitoring the effects of antiresorptive therapy of malignant osteolysis before any metastasis could be detected by other invasive techniques.
authors.affiliation: Department of Biochemistry, Istanbul Faculty of Medicine, Istanbull University, Capa, 34093 Istanbul, Turkey.
authors.forename: Zeynep Ozbek
authors.initials: ZO
authors.lastname: Kir
authors.forename: Pernur
authors.initials: P
authors.lastname: Oner
authors.forename: Yildiz Oner
authors.initials: YO
authors.lastname: Iyidoğan
authors.forename: Sembol
authors.initials: S
authors.lastname: Türkmen
authors.forename: Hikmet
authors.initials: H
authors.lastname: Koçak
authors.forename: Murat
authors.initials: M
authors.lastname: Koşer
authors.forename: Seden Ozbilen
authors.initials: SO
authors.lastname: Küçücük
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001859:Bone Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000097:blood / Q000473:pathology* / Q000652:urine; D002118:Calcium / Q000652:urine; D004150:Dipeptidases / Q000097:blood*; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D011237:Predictive Value of Tests
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D015675:Osteocalcin; C036020:deoxypyridinoline; D004150:Dipeptidases; C022449:proline dipeptidase; D002118:Calcium