title: Comparison of silicone oil versus gas tamponade in the treatment of idiopathic full-thickness macular hole.
abstract: OBJECTIVE
  To compare anatomic and functional outcomes of macular hole surgery with either silicone oil or C(3)F(8) gas tamponade.
  
  
  METHODS
  Retrospective comparative interventional study.
  
  
  METHODS
  Fifty-four eyes of 51 patients underwent pars plana vitrectomy for macular holes. Thirty-one eyes were treated with silicone oil tamponade, and 23 eyes were treated with C(3)F(8) tamponade.
  
  
  METHODS
  Demographics, preoperative and postoperative characteristics, and complications were analyzed.
  
  
  METHODS
  Preoperative and postoperative visual acuity, initial hole closure, number of persistent or recurrent holes, number of reoperations, and final hole closure.
  
  
  RESULTS
  The silicone oil and gas tamponade groups were demographically similar. The rate of hole closure after one operation with oil tamponade was significantly lower than that with gas tamponade (65% vs. 91%; P = 0.022). The percentage of patients undergoing a second operation was significantly higher in the oil group (35% vs. 4%; P = 0.006). However, with reoperations, the final rate of hole closure was similar between the oil and gas groups (90% vs. 96%; P = 0.628). The final median visual acuity for the gas group was significantly better than for the oil group (20/50 vs. 20/70; P = 0.047).
  
  
  CONCLUSIONS
  C(3)F(8) gas proved to be a more effective tamponade than silicone oil with respect to achieving initial closure of macular holes. Eyes receiving an oil tamponade required significantly more reoperations to achieve a similar rate of hole closure compared with eyes undergoing a gas tamponade. Final visual acuity was better for gas-operated eyes than for silicone-operated eyes.
authors.affiliation: Department of Ophthalmology, Duke Eye Center, Duke University Medical Center, Durham, North Carolina, USA.
authors.forename: James C
authors.initials: JC
authors.lastname: Lai
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Stinnett
authors.forename: Brooks W
authors.initials: BW
authors.lastname: McCuen
mesh_terms: D000368:Aged; D005260:Female; D005466:Fluorocarbons / Q000627:therapeutic use*; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D011183:Postoperative Complications; D011379:Prognosis; D012086:Reoperation; D012167:Retinal Perforations / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D012827:Silicone Oils / Q000627:therapeutic use*; D014792:Visual Acuity; D014821:Vitrectomy / Q000379:methods*
chemical_list: D005466:Fluorocarbons; D012827:Silicone Oils; C042852:perflutren