Event-related potential responses to alcohol-related stimuli in African-American young adults: relation to family history of alcoholism and drug usage.
OBJECTIVE
To use event-related potentials (ERPs) to investigate the response to alcohol-related stimuli in African-American young adults.


METHODS
ERPs to an object recognition task, that included pictures of objects, food and alcohol-related and non-alcohol-related drinks as stimuli, were obtained in 81 African-American young adult men and women (18-25 years old) without a personal history of alcohol dependence. Information on: psychiatric diagnoses, personal drinking and drug use history, and familial history of alcoholism was also obtained.


RESULTS
Family history was found to be associated with lowered P3 components and higher N1 components in response to the non-alcohol-related drinks. Additionally, an exploratory analyses revealed that lower amplitude N1 components were generated in response to alcohol-related stimuli in regular marijuana users compared with non-regular users. No associations of N1 or P3 amplitudes with conduct disorder symptoms or current drinking status were found in this population.


CONCLUSIONS
These studies demonstrated that family history is significantly and selectively associated with lower P3 amplitudes in this group of young adult men and women of African-American heritage. Additionally, current usage of marijuana and alcohol do not modify P3 amplitudes. However, regular marijuana use may diminish N1 response to alcohol-related stimuli, whereas, family history of alcoholism may augment N1 responses. Taken together these studies further suggest that ERPs can provide specific information on alcoholism risk as well as use of other misused drugs.
Ehlers
Cindy L
CL
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Phillips
Evelyn
E
Sweeny
Antonio
A
Slawecki
Craig J
CJ
D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000523:psychology*; D000437:Alcoholism / Q000208:ethnology / Q000235:genetics* / Q000523:psychology*; D000704:Analysis of Variance; D003463:Cues; D005071:Evoked Potentials / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D021641:Recognition, Psychology / Q000502:physiology; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000208:ethnology / Q000235:genetics / Q000523:psychology