Incorporation of adult organ-derived endothelial cells into tumor blood vessel.
In this study, we attempted to assess the incorporable potential of vascular endothelial cells derived from adult organ blood vessels into tumor blood vessels. Two kinds of adult organ-derived vascular endothelial cells, human aorta endothelial cells (HAEC) and umbilical vein endothelial cells (HUVEC), were administered into murine tumors inoculated to SCID mice. Many human blood vessel networks were visualized in the murine tumors. These cells in solid tumor not only survived and proliferated, but also incorporated into tumor endothelium. These results suggest that adult organ-derived vascular endothelial cells possess the potential to form the neovascular network in various tissues such as vascular endothelial progenitor-like cells in vivo. We propose that these cells can be regarded as a congenic (autologous) vector for vascular regeneration cell therapy and tumor vascular targeting gene therapy.
Koizumi
Keiichi
K
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, 565-0871, Osaka, Japan.
Tsutsumi
Yasuo
Y
Kamada
Haruhiko
H
Yoshioka
Yasuo
Y
Watanabe
Masaki
M
Yamamoto
Yoko
Y
Okamoto
Takayuki
T
Mukai
Yohei
Y
Nakagawa
Shinsaku
S
Tani
Yoichi
Y
Mayumi
Tadanori
T
D000328:Adult; D000818:Animals; D001011:Aorta / Q000166:cytology; D002455:Cell Division; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000473:pathology* / Q000637:transplantation; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D009389:Neovascularization, Pathologic; D012513:Sarcoma, Experimental / Q000098:blood supply*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology; D013997:Time Factors; D014471:Umbilical Veins / Q000166:cytology