Synthesis and conformational analysis of (E)-9,10-dehydroepothilone B: a suggestive link between the chemistry and biology of epothilones.
Yoshimura
Fumihiko
F
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA.
Rivkin
Alexey
A
Gabarda
Ana E
AE
Chou
Ting-Chao
TC
Dong
Huajin
H
Sukenick
George
G
Morel
Florence F
FF
Taylor
Richard E
RE
Danishefsky
Samuel J
SJ
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D034261:Epothilones / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D007262:Infusions, Intravenous; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008819:Mice, Nude; D008968:Molecular Conformation; D015394:Molecular Structure; D009368:Neoplasm Transplantation; D013997:Time Factors
D000970:Antineoplastic Agents; D034261:Epothilones; C093788:epothilone B