title: Butyrylcholinesterase and progression of cognitive deficits in dementia with Lewy bodies.
abstract: Butyrylcholinesterase is implicated in the pathology of AD. Selective inhibitors increase acetylcholine and improve cognitive function in animal models. In dementia with Lewy bodies, cholinergic activities are more affected than in AD. The authors report a highly significant association between temporal cortex butyrylcholinesterase activity and the rate of cognitive decline in a prospectively studied, autopsy-confirmed dementia with Lewy bodies series.
authors.affiliation: Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK. e.k.perry@ncl.ac.uk
authors.forename: Elaine
authors.initials: E
authors.lastname: Perry
authors.forename: Ian
authors.initials: I
authors.lastname: McKeith
authors.forename: Clive
authors.initials: C
authors.lastname: Ballard
mesh_terms: D000368:Aged; D002091:Butyrylcholinesterase / Q000378:metabolism*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000201:enzymology; D018450:Disease Progression; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000201:enzymology; D008297:Male; D011446:Prospective Studies; D013702:Temporal Lobe / Q000201:enzymology
chemical_list: D002091:Butyrylcholinesterase