title: Arterial thrombosis induced by IVIg and its treatment with tPA.
abstract: IV immunoglobulin therapy can lead to vascular events through increased serum viscosity and possibly other mechanisms. The authors describe the successful use of tissue plasminogen activator in three of four patients who developed cerebral and peripheral arterial thrombosis after treatment with IV immunoglobulin.
authors.affiliation: Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA. ksivakumar@chw.edu
authors.forename: Darin
authors.initials: D
authors.lastname: Okuda
authors.forename: Murray
authors.initials: M
authors.lastname: Flaster
authors.forename: James
authors.initials: J
authors.lastname: Frey
authors.forename: Kumaraswamy
authors.initials: K
authors.lastname: Sivakumar
mesh_terms: D001158:Arteries; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects*; D020767:Intracranial Thrombosis / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000188:drug therapy / Q000209:etiology; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D016756:Immunoglobulins, Intravenous; D010959:Tissue Plasminogen Activator