title: Add-on or step-up trials for new drug development in rheumatoid arthritis: a new standard?
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands. keb.info@vumc.nl
authors.forename: Maarten
authors.initials: M
authors.lastname: Boers
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic / Q000379:methods* / Q000592:standards; D003657:Decision Making; D004359:Drug Therapy, Combination; D015507:Drugs, Investigational / Q000627:therapeutic use*; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D012107:Research Design / Q000592:standards
chemical_list: D018501:Antirheumatic Agents; D015507:Drugs, Investigational; D008727:Methotrexate