Organoplatinum(II) complexes as a color biomarker in solid-phase peptide chemistry and screening.
[reaction: see text] A novel organoplatinum(II) biomarker is introduced to facilitate the solid-phase screening of combinatorial libraries for substrates and inhibitors of enzymes and receptors. The robust organoplatinum(II) biomarker can be incorporated, on amine functions, in peptides using standard peptide coupling techniques. The chemistry, stability, and (reversible) coloration process with KI(3) of the organoplatinum(II) biomarker was investigated.
Guillena
Gabriela
G
Debye Institute, Department of Metal-Mediated Synthesis, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
Halkes
Koen M
KM
Rodríguez
Gema
G
Batema
Guido D
GD
van Koten
Gerard
G
Kamerling
Johannis P
JP
D000595:Amino Acid Sequence; D015415:Biomarkers / Q000032:analysis / Q000737:chemistry*; D003116:Color; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010455:Peptides / Q000032:analysis* / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D015415:Biomarkers; D009944:Organoplatinum Compounds; D010455:Peptides