Lewis acid-induced intramolecular Friedel-Crafts cyclization of 1,3-bis-exocyclic dienes. a new route to 4a-methyltetrahydrofluorenes.
[reaction: see text] An efficient new method for constructing the 4a-methyltetrahydrofluorene skeleton was achieved via Friedel-Crafts intramolecular cyclization of 1,3-bis-exocyclic dienes. This strategy offers a simple and promising method for accessing complex structures.
Lomberget
Thierry
T
Laboratoire de Chimie Organique 1, associé au CNRS, Université Claude Bernard Lyon 1, CPE, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne, France.
Bentz
Emilie
E
Bouyssi
Didier
D
Balme
Geneviève
G
D000466:Alkadienes / Q000737:chemistry*; D001896:Boron Compounds / Q000737:chemistry; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D003500:Cyclization; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation
D000466:Alkadienes; D001896:Boron Compounds; D005449:Fluorenes