title: Why is otosclerosis of low prevalence in Japanese?
abstract: OBJECTIVE
  This study aimed to clarify the reasons why clinical otosclerosis, a very common disease among Caucasians, is not prevalent among Japanese.
  
  
  METHODS
  The incidence, site, activity, and volume of otosclerotic foci were examined in 1011 temporal bone sections from 507 Japanese individuals.
  
  
  METHODS
  This study was prepared at the temporal bone laboratory, Fukushima Medical University, Fukushima.
  
  
  RESULTS
  Otosclerotic foci were observed in 2.56% of individuals and in 1.48% of the ears. The most common site of involvement was anterior to the oval window region, but this was only in 38.9% of the ears with otosclerotic foci. The otosclerotic foci were not involved in the stapediovestibular articulation or the endosteal layer of the otic capsule in any ears. An active change of the otosclerotic focus was seen in 33.3% of ears with otosclerosis. The volume of otosclerotic foci at the site anterior to the oval window region was less than 0.8 mm3 in 5 out of 7 ears.
  
  
  CONCLUSIONS
  The incidence of histologic otosclerosis among Japanese seemed to be almost the same as that among Caucasians. Three reasons why clinical otosclerosis was not as prevalent among Japanese as among Caucasians are suggested: low incidence of involvement of foci anterior to the oval window, low activity, and small lesion without involvement of the footplate and/or membranous labyrinth of the inner ear.
authors.affiliation: Department of Otolaryngology, Fukushima Medical University, Fukushima, Japan. iohtani@fmu.ac.jp
authors.forename: Iwao
authors.initials: I
authors.lastname: Ohtani
authors.forename: Yohko
authors.initials: Y
authors.lastname: Baba
authors.forename: Tomoko
authors.initials: T
authors.lastname: Suzuki
authors.forename: Chiaki
authors.initials: C
authors.lastname: Suzuki
authors.forename: Makoto
authors.initials: M
authors.lastname: Kano
authors.forename: Ramesh C
authors.initials: RC
authors.lastname: Deka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003638:Deafness / Q000453:epidemiology / Q000209:etiology; D004432:Ear, Middle / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010040:Otosclerosis / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D015995:Prevalence; D013701:Temporal Bone / Q000473:pathology