What should be the cut-off level of serum CA125 to evaluate the disease status before second-look laparotomy in epithelial ovarian carcinoma?
To assess the predictive value of serum CA125 level prior to second-look laparotomy in epithelial ovarian carcinoma, 45 patients who were clinically or radiologically tumor-free prior to a second-look laparotomy were studied. Serum CA125 levels were measured 10 days prior to the operation, and were compared with the surgico-pathological results. Twenty-eight (62%) patients were found to have tumor at surgery. The serum CA125 levels were > or = 35 U ml-1 (42%) patients. Tumors were found in 14 (74%) of these 19 patients. Although a serum CA125 level > or = 35 U ml-1 was a strong predictor of the presence of an intraperitoneal tumor, a level <35 U ml-1 was not predictive of a tumor-free state. When the cut-off level was accepted as 20 U ml-1, 28 patients (62%) were found to have elevated CA125 level. The sensitivity, the specificity, the positive and negative predictive value and the false negative ratio were calculated as 79%, 65%, 79%, 65% and 21% respectively. The threshold value for a raised CA125 level was considered and a lower level of 20 U ml-1 was suggested as a cut-off level prior to second-look laparotomy in evaluating patients with known epithelial ovarian cancer.
Beşe
T
T
Department of Obstetrics and Gynecology, Cerrahpaşa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Demirkiran
F
F
Arvas
M
M
Oz
A U
AU
Kösebay
D
D
Erkün
E
E