title: A pure nongestational choriocarcinoma of the ovary diagnosed with DNA polymorphism analysis.
abstract: BACKGROUND
  Choriocarcinoma arises in the ovary from gestational or nongestational origin. Nongestational choriocarcinoma of the ovary is extremely rare and the pure type is less frequent than the mixed type with other germ cell tumors. Diagnosis of pure nongestational choriocarcinoma is very difficult without genetic analysis.
  
  
  METHODS
  We report a pure nongestational choriocarcinoma primarily arising in a 19-year-old woman's ovary. Following abdominal operative procedure, careful examination of the tumor revealed pure choriocarcinoma without combination of other germ cell tumors. We confirmed its nongestational origin by DNA polymorphism analysis. Multiple courses of chemotherapy with an EMA/CO regimen were effective for this case.
  
  
  CONCLUSIONS
  Genetic analysis is useful tool in determining the origin of choriocarcinoma. We could distinguish the genetic origin of this tumor analyzing only two or three appropriate VNTR loci.
authors.affiliation: Department of Obstetrics and Gynecology, Fukuoka University School of Medicine, Fukuoka, Japan. tsujioka@fukuoka-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsujioka
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hamada
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyakawa
authors.forename: Toru
authors.initials: T
authors.lastname: Hachisuga
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Kawarabayashi
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002822:Choriocarcinoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic
chemical_list: D004273:DNA, Neoplasm