Telomerase reactivation in malignant gliomas and loss of heterozygosity on 10p15.1.
An inhibitor of telomerase activity maps to chromosome 10p15.1. A series of 51 high-grade gliomas was analyzed for loss of heterozygosity (LOH) on chromosome 10 and for telomerase activity. In univariate analysis, LOH10p (59%) and LOH10q (61%) were associated with telomerase activity (55%; p < 0.0001 and p = 0.0006). In multivariate analysis, only LOH10p remained statistically related to telomerase activity, suggesting that the telomerase repressor gene located on 10p15.1 is inactivated in high-grade gliomas.
Leuraud
P
P
INSERM U495, Groupe hospitalier Pitié-Salpêtrière and Université Pierre et Marie Curie, Paris, France.
Aguirre-Cruz
L
L
Hoang-Xuan
K
K
Crinière
E
E
Tanguy
M-L
ML
Golmard
J-L
JL
Kujas
M
M
Delattre
J-Y
JY
Sanson
M
M
D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D005910:Glioma / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D019656:Loss of Heterozygosity; D019098:Telomerase / Q000378:metabolism*
D019098:Telomerase