Cow milk angiogenin induces cytokine production in human blood leukocytes.
Angiogenin isolated from cow milk induces the production of cytokines IL-1beta, IL-6, and TNF-alpha in human leukocytes; the level of production of each cytokine depends on the concentration of the preparation, and the dynamics of production depends on the time from the beginning of induction. Simultaneous treatment with angiogenin and phytohemagglutinin had an additive effect on the production of cytokines, the time of this effect manifestation being individual for each cytokine.
Shcheglovitova
O N
ON
N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow.
Maksyanina
E V
EV
Ionova
I I
II
Rustam'yan
Yu L
YL
Komolova
G S
GS
D043925:Angiogenesis Inducing Agents / Q000378:metabolism; D000818:Animals; D002417:Cattle; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D007962:Leukocytes / Q000276:immunology*; D008892:Milk / Q000737:chemistry*; D010835:Phytohemagglutinins / Q000494:pharmacology; D012259:Ribonuclease, Pancreatic / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D043925:Angiogenesis Inducing Agents; D007375:Interleukin-1; D015850:Interleukin-6; D010835:Phytohemagglutinins; D014409:Tumor Necrosis Factor-alpha; C046366:angiogenin; D012259:Ribonuclease, Pancreatic