Regulation of PPAR-gamma gene in human promyelocytic HL-60 cell line.
The present study employed human promyelocytic cell line, HL-60, as an archetype model to understand the role of cholesterol receptors (Receptor-C(k) and oxysterol-specific receptor-transcription factor LxR-alpha) in the regulation of PPAR-gamma gene recognized to control cellular differentiation and apoptosis. Such a study revealed that Receptor "C(k)"-dependent signalling pathway not only regulates PPAR-gamma gene transcription but also provides ligands for the activation of this nuclear receptor superfamily of transcription factors that control hematopoiesis. Based upon these and our earlier results, we propose a molecular cross-talk pathway between cholesterol-specific cell surface Receptor-C(k) and nuclear receptors (LxR-alpha and PPAR-gamma), which may add a new dimension in the understanding and control of leukemogenesis.
Kaul
D
D
Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, 160 012 Chandigarh, India. dkaul_24@hotmail.com
Anand
P K
PK
D004268:DNA-Binding Proteins; D005786:Gene Expression Regulation; D006098:Granulocytes / Q000378:metabolism*; D018922:HL-60 Cells; D006801:Humans; D006888:Hydroxycholesterols / Q000494:pharmacology; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D020239:Receptor Cross-Talk; D018160:Receptors, Cytoplasmic and Nuclear / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D018110:Receptors, Lipoprotein / Q000502:physiology; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D006888:Hydroxycholesterols; D000071518:Liver X Receptors; C000605213:NR1H3 protein, human; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D018110:Receptors, Lipoprotein; D014157:Transcription Factors; C113493:receptor-Ck; C007997:25-hydroxycholesterol