title: Four new cycloartane glycosides from Aquilegia vulgaris and their immunosuppressive activities in mouse allogeneic mixed lymphocyte reaction.
abstract: Four new cycloartane glycosides, named aquilegiosides C-F, were isolated from the dried aerial parts of Aquilegia vulgaris. Their structures were determined by two dimensional (2D) NMR spectroscopic analysis and chemical evidence. Aquilegiosides C-F suppressed the proliferation of lymphocytes in mouse allogeneic mixed lymphocyte reaction with IC(50), ranging from 3.7x10(-5) to 2.2x10(-4) M.
authors.affiliation: Faculty of Engineering, Kyushu Kyoritsu University, Kitakyushu, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Nishida
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yoshimitsu
authors.forename: Masafumi
authors.initials: M
authors.lastname: Okawa
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nohara
mesh_terms: D000818:Animals; D031884:Aquilegia / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects / Q000276:immunology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D006027:Glycosides; D007166:Immunosuppressive Agents; D010936:Plant Extracts; D014315:Triterpenes; C085352:cycloartane