High levels of urinary midkine in various cancer patients.
Midkine (MK) is a heparin-binding growth factor, which promotes growth, migration, and survival of various cells, and MK expression is increased in many human carcinomas. We determined the urinary MK level by enzyme-linked immunoassay. Taking 311pg/mg creatinine as a cut-off level, 70% of patients with various carcinomas (n=142) gave positive values, while only 5.5% of healthy volunteers (n=330) did. In case of gastric carcinoma, 17 out of 21 patients with stage 1 tumor were positive. Urinary MK levels are expected to become a convenient marker as an aid in detection of tumors.
Ikematsu
Shinya
S
Meiji Dairies Corporation, 540 Naruda, Odawara, Kanagawa 250-0862, Japan.
Okamoto
Kohji
K
Yoshida
Yoshihiro
Y
Oda
Munehiro
M
Sugano-Nagano
Hitomi
H
Ashida
Kinya
K
Kumai
Hideshi
H
Kadomatsu
Kenji
K
Muramatsu
Hisako
H
Takashi Muramatsu
Sakuma
Sadatoshi
S
D000328:Adult; D000367:Age Factors; D000368:Aged; D014408:Biomarkers, Tumor; D015153:Blotting, Western; D002277:Carcinoma / Q000652:urine; D002352:Carrier Proteins / Q000652:urine*; D016022:Case-Control Studies; D003404:Creatinine / Q000652:urine; D016207:Cytokines; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000078792:Midkine; D009369:Neoplasms / Q000175:diagnosis / Q000652:urine*; D013997:Time Factors
D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D016207:Cytokines; D000078792:Midkine; D003404:Creatinine