The cholecystokinin antagonist proglumide enhances the analgesic effect of dihydrocodeine.
OBJECTIVE
To investigate the potential pro-analgesic effect of the non-specific CCK antagonist proglumide on the analgesia produced by dihydrocodeine.


METHODS
A double-blind, placebo-controlled crossover study of 30 adult subjects.


RESULTS
Mean pain scores fell from a baseline of 8.12-7.89 during the placebo phase (N.S.) and to 6.82 during the proglumide phase (P < 0.05). Side effects were minor.


CONCLUSIONS
The CCK antagonist proglumide enhances the analgesic effect of dihydrocodeine.
McCleane
Gary J
GJ
Rampark Pain Centre, Lurgan, Northern Ireland, United Kingdom. gary@mccleane.freeserve.co.uk
D000328:Adult; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage; D002766:Cholecystokinin / Q000037:antagonists & inhibitors; D002908:Chronic Disease; D003061:Codeine / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D015990:Placebo Effect; D011377:Proglumide / Q000008:administration & dosage*; D016896:Treatment Outcome
D000700:Analgesics; D002766:Cholecystokinin; D011377:Proglumide; C014481:dihydrocodeine; D003061:Codeine