Parallel approach to selective catalysts for palladium-catalyzed desymmetrization of 2,4-cyclopentenediol.
[reaction: see text] Work toward the development of a bis-phosphine ligand system for the palladium-catalyzed desymmetrization of meso-diols is reported. A parallel approach using phosphine-containing amino acids and a "representational search" was taken to find a polymer-supported catalyst system. The selectivities reported are comparable to many other polymer-bound asymmetric catalysts.
Agarkov
Anton
A
Department of Chemistry, Washington University, One Brookings Drive, Campus Box 1134, Saint Louis, Missouri 63130-4899, USA.
Uffman
Eric W
EW
Gilbertson
Scott R
SR
D000438:Alcohols / Q000737:chemistry*; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D002384:Catalysis; D003517:Cyclopentanes / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry; D017433:Protein Structure, Secondary; D013237:Stereoisomerism
D000438:Alcohols; D000596:Amino Acids; D003517:Cyclopentanes; D009842:Oligopeptides; D009944:Organoplatinum Compounds; D010720:Phosphines