A memory GAP.
Pavlovian conditioning of the response to fear has provided an important model for memory formation in mammals. Several studies have begun to identify the key signal-transduction components that provide the molecular basis for this complex neural process. A recent report has revealed that the Rho GTPase and its regulator p190 Rho-GTPase-activating protein (p190 RhoGAP) also play an important regulatory role in fear memory formation.
Settleman
Jeffrey
J
Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA. settleman@helix.mgh.harvard.edu
D000818:Animals; D003214:Conditioning, Classical / Q000502:physiology*; D005239:Fear / Q000502:physiology*; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism; D017774:Long-Term Potentiation / Q000502:physiology; D008568:Memory / Q000502:physiology*; D009687:Nuclear Proteins / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
D020662:Guanine Nucleotide Exchange Factors; D009687:Nuclear Proteins; D020741:rho GTP-Binding Proteins