Molecular mechanisms of filovirus cellular trafficking.
The filoviruses, Ebola and Marburg, are two of the most pathogenic viruses, causing lethal hemorrhagic fever in humans. Recent discoveries suggest that filoviruses, along with other phylogenetically or functionally related viruses, utilize a complex mechanism of replication exploiting multiple cellular components including lipid rafts, endocytic compartments, and vacuolar protein sorting machinery. In this review, we summarize these recent findings and discuss the implications for vaccine and therapeutics development.
Aman
M Javad
MJ
Clinical Research Management Inc., 1425 Porter Street, Frederick, MD 21702, USA. amanm@ncifcrf.gov
Bosio
Catharine M
CM
Panchal
Rekha G
RG
Burnett
James C
JC
Schmaljohn
Alan
A
Bavari
Sina
S
D001692:Biological Transport; D016563:Filoviridae / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D021962:Membrane Microdomains / Q000378:metabolism; D008957:Models, Genetic; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism; D014763:Viral Matrix Proteins / Q000378:metabolism; D054334:Viral Regulatory and Accessory Proteins / Q000378:metabolism; D014771:Virion / Q000502:physiology; D019065:Virus Assembly; D014779:Virus Replication / Q000235:genetics
C081324:GP-protein, Marburg virus; C080981:VP40 protein, virus; D014759:Viral Envelope Proteins; D014763:Viral Matrix Proteins; D054334:Viral Regulatory and Accessory Proteins; C113189:envelope glycoprotein, Ebola virus