title: Incorporation of adult organ-derived endothelial cells into tumor blood vessel.
abstract: In this study, we attempted to assess the incorporable potential of vascular endothelial cells derived from adult organ blood vessels into tumor blood vessels. Two kinds of adult organ-derived vascular endothelial cells, human aorta endothelial cells (HAEC) and umbilical vein endothelial cells (HUVEC), were administered into murine tumors inoculated to SCID mice. Many human blood vessel networks were visualized in the murine tumors. These cells in solid tumor not only survived and proliferated, but also incorporated into tumor endothelium. These results suggest that adult organ-derived vascular endothelial cells possess the potential to form the neovascular network in various tissues such as vascular endothelial progenitor-like cells in vivo. We propose that these cells can be regarded as a congenic (autologous) vector for vascular regeneration cell therapy and tumor vascular targeting gene therapy.
authors.affiliation: Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, 565-0871, Osaka, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Koizumi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Tsutsumi
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Kamada
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: Masaki
authors.initials: M
authors.lastname: Watanabe
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Okamoto
authors.forename: Yohei
authors.initials: Y
authors.lastname: Mukai
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Tani
authors.forename: Tadanori
authors.initials: T
authors.lastname: Mayumi
mesh_terms: D000328:Adult; D000818:Animals; D001011:Aorta / Q000166:cytology; D002455:Cell Division; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000473:pathology* / Q000637:transplantation; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D009389:Neovascularization, Pathologic; D012513:Sarcoma, Experimental / Q000098:blood supply*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology; D013997:Time Factors; D014471:Umbilical Veins / Q000166:cytology