Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate.
Diphenhydramine, a common ingredient in over-the-counter medications, is often taken in overdose. Toxicity is usually limited to anticholinergic symptoms. However, because diphenhydramine also exhibits type IA sodium channel blockade, cardiac toxicity is also possible. Although it would be expected that, like other type IA toxicities, diphenhydramine-induced cardiotoxicity could be responsive to hypertonic sodium bicarbonate, this finding is largely unappreciated. We describe 3 cases of diphenhydramine-induced cardiac toxicity that were responsive to bicarbonate.
Sharma
Adhi N
AN
New York City Poison Control Center, New York, NY, USA. ansharma@pol.net
Hexdall
Aaron H
AH
Chang
Elbert K
EK
Nelson
Lewis S
LS
Hoffman
Robert S
RS
D000082:Acetaminophen / Q000506:poisoning; D000328:Adult; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000188:drug therapy*; D001241:Aspirin / Q000506:poisoning; D004155:Diphenhydramine / Q000506:poisoning*; D004338:Drug Combinations; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006982:Hypertonic Solutions; D006993:Hypnotics and Sedatives / Q000506:poisoning; D007262:Infusions, Intravenous; D008297:Male; D008701:Methapyrilene / Q000506:poisoning; D004366:Nonprescription Drugs / Q000506:poisoning; D012457:Salicylamides / Q000506:poisoning; D017693:Sodium Bicarbonate / Q000008:administration & dosage*; D013406:Suicide, Attempted; D016896:Treatment Outcome
D004338:Drug Combinations; D006982:Hypertonic Solutions; D006993:Hypnotics and Sedatives; D004366:Nonprescription Drugs; D012457:Salicylamides; D000082:Acetaminophen; D004155:Diphenhydramine; D017693:Sodium Bicarbonate; D008701:Methapyrilene; D001241:Aspirin