title: Biomechanical bone strength and bone mass in young male and female rats fed a fish oil diet.
abstract: The study objective was to determine if male and female rats fed a diet rich in fish oil had femurs and vertebrae that were stronger and more resistant to fracture than rats not fed omega-3 long chain polyunsaturated fatty acids. Weanling rats were randomized to a control or a fish oil diet for 5 weeks. Feeding fish oil to males had no effect on biomechanical strength properties of femurs and vertebrae as measured by three point bending and compression, respectively. In contrast, females fed fish oil had reduced length growth and a lower vertebral peak load. These effects may have been partly mediated by a lower food intake but were not associated with differences in serum IGF-I, estradiol or urinary calcium. The effect of consuming a fish oil diet into later adulthood should be investigated to determine if femur strength is also affected among females.
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ont., Toronto, Canada M5S 3E2.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Sirois
authors.forename: Angela M
authors.initials: AM
authors.lastname: Cheung
authors.forename: Wendy E
authors.initials: WE
authors.lastname: Ward
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D001846:Bone Development / Q000187:drug effects*; D002118:Calcium / Q000652:urine; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005269:Femur / Q000187:drug effects / Q000502:physiology; D005395:Fish Oils / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000502:physiology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013024:Soybean Oil / Q000494:pharmacology; D013718:Tensile Strength / Q000187:drug effects; D013739:Testosterone / Q000097:blood
chemical_list: D004041:Dietary Fats; D005395:Fish Oils; C033266:Menhaden oil; D013739:Testosterone; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D013024:Soybean Oil; D002118:Calcium