title: Extra amino group-containing gramicidin S analogs possessing outer membrane-permeabilizing activity.
abstract: Novel (2S,4R)- and (2S,4S)-4-aminoproline residue-containing analogs of the cyclic decapeptide antibiotic gramicidin S were synthesized, which exhibited marked permeabilizing activity on the outer membrane of gram-negative bacteria.
authors.affiliation: Department of Applied Chemistry, Nagoya Institute of Technology, Nagoya 466-8555, Japan. kawai@ach.nitech.ac.jp
authors.forename: Masao
authors.initials: M
authors.lastname: Kawai
authors.forename: Ryoji
authors.initials: R
authors.lastname: Tanaka
authors.forename: Hatsuo
authors.initials: H
authors.lastname: Yamamura
authors.forename: Keiko
authors.initials: K
authors.lastname: Yasuda
authors.forename: Shizuto
authors.initials: S
authors.lastname: Narita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Umemoto
authors.forename: Setsuko
authors.initials: S
authors.lastname: Ando
authors.forename: Takashi
authors.initials: T
authors.lastname: Katsu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006096:Gramicidin / Q000031:analogs & derivatives* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000900:Anti-Bacterial Agents; D006096:Gramicidin