title: Regional body composition in adolescents with anorexia nervosa and changes with weight recovery.
abstract: BACKGROUND
  Studies of regional fat distribution in adults with anorexia nervosa (AN) have shown decreased extremity fat at baseline and increased trunk fat with weight recovery, resulting in truncal adiposity. Little is known about fat distribution in adolescents with AN, especially with weight recovery.
  
  
  OBJECTIVE
  We sought to determine whether regional fat distribution in adolescents with AN is comparable with that in healthy adolescents and whether weight recovery results in increased trunk fat and truncal adiposity.
  
  
  METHODS
  In 21 adolescent girls with AN and 21 control subjects matched for age and pubertal stage, we measured body-composition variables with dual-energy X-ray absorptiometry at baseline, 6 mo, and 12 mo. Weight recovery was defined as a > or = 10% increase in body mass index.
  
  
  RESULTS
  At baseline, the girls with AN had a lower percentage of trunk fat than did the control subjects, whereas the percentage of extremity fat was not significantly different between the groups. Weight recovery in 13 subjects with AN resulted in an increased percentage of trunk fat and an increased ratio of trunk fat to extremity fat; however, this ratio did not exceed that of control subjects.
  
  
  CONCLUSIONS
  In adolescents with AN, trunk fat rather than extremity fat is reduced. Weight recovery is associated with increased trunk fat and an increased ratio of trunk fat to extremity fat. In contrast with previous findings in adults, this most likely represents normalization of fat distribution rather than development of truncal adiposity.
authors.affiliation: Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA.
authors.forename: Madhusmita
authors.initials: M
authors.lastname: Misra
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Soyka
authors.forename: Karen K
authors.initials: KK
authors.lastname: Miller
authors.forename: Steven
authors.initials: S
authors.lastname: Grinspoon
authors.forename: Lynne L
authors.initials: LL
authors.lastname: Levitsky
authors.forename: Anne
authors.initials: A
authors.lastname: Klibanski
mesh_terms: D000005:Abdomen; D000273:Adipose Tissue / Q000473:pathology; D000293:Adolescent; D000856:Anorexia Nervosa / Q000503:physiopathology*; D001823:Body Composition; D016022:Case-Control Studies; D005121:Extremities; D005260:Female; D006801:Humans; D013909:Thorax; D015430:Weight Gain