Paired-like repression/activation in pituitary development.
Pituitary gland development is controlled by signals that guide expression of specific combinations of transcription factors that dictate serial determination and differentiation events. One class of factors is paired-like homeodomain factors. Two that have been investigated are the repressor Hex1/Rpx and activator prophet of Pit-1 (Prop-1), which exert selective roles during pituitary development. The opposing actions of these factors provide one aspect of pituitary organogenesis.
Olson
Lorin E
LE
Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla, California 92093-0648, USA.
Dasen
Jeremy S
JS
Ju
Bong Gun
BG
Tollkuhn
Jessica
J
Rosenfeld
Michael G
MG
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009154:Mutation; D038081:Organogenesis; D010902:Pituitary Gland / Q000196:embryology / Q000254:growth & development*; D000072056:Transcription Factor HES-1
D051792:Basic Helix-Loop-Helix Proteins; D018398:Homeodomain Proteins; D000072056:Transcription Factor HES-1; C102134:Prophet of Pit-1 protein; C078493:HES1 protein, human