The first total synthesis of nakadomarin A.
(-)-Nakadomarin A is a member of manzamine alkaloid isolated from a marine sponge and have a unique hexacyclic structure. The first total synthesis of (+)-nakadomarin A, an enantiomer of natural product, has been accomplished from stereochemically defined 4-oxopiperidin-3-carboxylic acid derivative. The synthesis established the structure of nakadomarin A including absolute configuration.
Nagata
Toshiaki
T
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
Nakagawa
Masako
M
Nishida
Atsushi
A
D000470:Alkaloids / Q000138:chemical synthesis*; D000818:Animals; D002243:Carbolines / Q000138:chemical synthesis*; D005663:Furans / Q000138:chemical synthesis; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry
D000470:Alkaloids; D002243:Carbolines; D005663:Furans; C476640:nakadomarin A