title: Synthesis and antiherpetic activity of acyclovir phosphonates.
abstract: Phosphonate derivatives of acyclovir containing phosphorous acid and ethoxycarbonylphosphonic acid residues as well as their isopropyl esters were prepared. They selectively inhibited the herpes simplex virus 1 reproduction in Vero cell culture, the efficacy of esters being 3-4 times higher than that of ACV. The hydrolysis of the synthesized compounds was studied in the PBS buffer and human blood serum.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Medical Sciences, Moscow, Russian Federation.
authors.forename: Inna L
authors.initials: IL
authors.lastname: Karpenko
authors.forename: Maxim V
authors.initials: MV
authors.lastname: Jasko
authors.forename: Valeriya L
authors.initials: VL
authors.lastname: Andronova
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Ivanov
authors.forename: Marina K
authors.initials: MK
authors.lastname: Kukhanova
authors.forename: Georgy A
authors.initials: GA
authors.lastname: Galegov
authors.forename: Yury S
authors.initials: YS
authors.lastname: Skoblov
mesh_terms: D000212:Acyclovir / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010755:Organophosphates / Q000097:blood / Q000737:chemistry; D063065:Organophosphonates / Q000737:chemistry*; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D010755:Organophosphates; D063065:Organophosphonates; D000212:Acyclovir