title: Deficiency of protein S-mediated familial venous thrombophilia--a case report.
abstract: Deficiency of protein S causes potential problems of thrombosis. Cases of familial venous thrombosis due to deficiency of protein S were presented. First, an 85-year-old woman had pulmonary thromboembolism due to left deep femoral venous thrombosis, which might be triggered by leg fracture and the long-term treatment with a plaster cast. Next, her 29-year-old granddaughter had episodes of recurrent venous thrombosis in her legs and arms, which might be triggered by the treatment with a plaster cast and abortion. In the latter part, the aspects of risks for thromboembolism, potential problems in gestational period, and an advisability of thromboprophylaxis in patients with deficiency of protein S are described.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. tomoharada-circ@umin.ac.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Harada
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Morita
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Imai
authors.forename: Doubun
authors.initials: D
authors.lastname: Hayashi
authors.forename: Norihiko
authors.initials: N
authors.lastname: Takeda
authors.forename: Koji
authors.initials: K
authors.lastname: Maemura
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yazaki
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D006801:Humans; D018455:Protein S Deficiency / Q000150:complications* / Q000235:genetics; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D012307:Risk Factors; D019851:Thrombophilia / Q000209:etiology* / Q000235:genetics / Q000628:therapy
chemical_list: D000925:Anticoagulants