RNA repair: damage control.
RNA in a cell is subject to many of the same insults as DNA. RNA damage can induce apoptosis and may be exploited for anti-cancer chemotherapy. It is a surprise, however, to learn that cells may repair RNA damage, suggesting a far greater significance of RNA in genotoxic stress.
Bellacosa
Alfonso
A
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA. a_bellacosa@fccc.edu
Moss
Eric G
EG
D000478:Alkylation; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D004249:DNA Damage / Q000502:physiology; D004260:DNA Repair / Q000502:physiology; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D012313:RNA / Q000502:physiology*; D020871:RNA Stability / Q000502:physiology*
D012313:RNA