[Therapeutic indications of intravenous immunoglobulins].
Intravenous Immunoglobulin (IVIg) provide a wide spectrum of antibody specificities in patients with antibody deficiencies and restore immune homeostasis in patients with auto-immune diseases. Controlled trials have now been performed in a large number of diseases: in primary and secondary antibody deficiencies, auto-immune neurological diseases and various other auto-immune or systemic inflammatory conditions. Mechanisms of action of IVIg are multiple and often associated for a given disease. These mechanisms are however incompletely understood and therapeutic effect of IVIg remains to be investigated in a wide range of diseases.
Tellier
Z
Z
Laboratoire du fractionnement et des biotechnologies, direction des affaires médicales et de la recherche clinique, 3, avenue des Tropiques, BP 305, 91958 cedex, Les Ulis, France. tellier@lfb.fr <tellier@lfb.fr>
Mouthon
L
L
D000918:Antibody Specificity; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D004406:Dysgammaglobulinemia / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy* / Q000276:immunology; D033581:Stem Cell Transplantation
D016756:Immunoglobulins, Intravenous