title: Highly stereoselective anti SN2' substitutions of (Z)-allylic pentafluorobenzoates with polyfunctionalized zinc-copper reagents.
abstract: [reaction: see text] Allylic substitution reactions of zinc-copper organometallics on (Z)-allylic pentafluorobenzoates proceed with very high regioselectivity and excellent anti selectivity. The high fidelity in transfer of stereochemical information allowed a short synthesis of (+)-ibuprofen (97% ee).
authors.affiliation: Department Chemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377, München, Germany.
authors.forename: Nicole
authors.initials: N
authors.lastname: Harrington-Frost
authors.forename: Helena
authors.initials: H
authors.lastname: Leuser
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Calaza
authors.forename: Florian F
authors.initials: FF
authors.lastname: Kneisel
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel