title: No difference in symptoms during challenges with homogenized and unhomogenized cow's milk in subjects with subjective hypersensitivity to homogenized milk.
abstract: It has been hypothesized that certain consumers tolerate untreated cow's milk, but react to processed (i.e. homogenized and pasteurized) cow's milk although they do not suffer from IgE-mediated cow's milk allergy or lactose intolerance. The aim of the study was to compare the tolerance of unhomogenized and homogenized cow's milk in lactose tolerant adults who had repeatedly experienced better tolerance of unhomogenized than homogenized milk. Forty-four subjects were challenged with homogenized and unhomogenized cow's milk for five days in a randomized, double-blind, cross-over study. No differences in the symptoms during the challenges were found. Roughly half the subjects tolerated the homogenized milk better and the other half tolerated the unhomogenized milk better. The results of this study show no difference in the tolerance of homogenized and unhomogenized milk in adults with self-reported symptoms suggestive of hypersensitivity to homogenized milk.
authors.affiliation: Division of Nutrition, Dept. of Applied Chemistry and Microbiology, FIN-00014 University of Helsinki, Finland.
authors.forename: Laura
authors.initials: L
authors.lastname: Paajanen
authors.forename: Tuula
authors.initials: T
authors.lastname: Tuure
authors.forename: Tuija
authors.initials: T
authors.lastname: Poussa
authors.forename: Riitta
authors.initials: R
authors.lastname: Korpela
mesh_terms: D015746:Abdominal Pain; D000293:Adolescent; D000328:Adult; D000818:Animals; D018592:Cross-Over Studies; D003967:Diarrhea; D004311:Double-Blind Method; D005260:Female; D005414:Flatulence; D005511:Food Handling; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008875:Middle Aged; D008892:Milk; D016269:Milk Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D009325:Nausea