Synthesis, isolation, and characterization of 2'-paclitaxel glycinate: an application of the Bsmoc protecting group.
The relevance of the Bsmoc protecting group in the synthesis of moisture- and base-sensitive compounds has been demonstrated by the preparation of 2'-paclitaxel glycinate with use of the solid anhydrous base, 4-piperidinopiperidine in DCM solvent.
Greenwald
Richard B
RB
Enzon Pharmaceuticals, Inc., 20 Kingsbridge Road, Piscataway, NJ 00854, USA. richard.greenwald@enzon.com
Zhao
Hong
H
Reddy
Prasanna
P
D002851:Chromatography, High Pressure Liquid; D007202:Indicators and Reagents; D015394:Molecular Structure; D017239:Paclitaxel / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D043823:Taxoids / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification
D007202:Indicators and Reagents; D043823:Taxoids; C113924:poly(ethylene glycol)-conjugated paclitaxel-2'-glycinate; D011092:Polyethylene Glycols; D017239:Paclitaxel