title: The history and future of implantation therapy for gastroesophageal reflux disease.
abstract: The initial development of endoscopic implantation techniques for the treatment of gastroesophageal reflux disease in the 1980s helped set the stage for current implantation techniques and studies, which now include more than 500 patients. The relative simplicity of these techniques adds to their attraction. Ultimately, multiple factors, including therapeutic efficacy durability, safety, simplicity, and cost-effectiveness, will determine clinical application of these techniques. This article focuses on transoral endoscopic implantation, although surgical, transcutaneous, and other endoscopic routes have been used as well.
authors.affiliation: Indiana University Medical Center, 550 North University Boulevard, Suite 4100, Indianapolis, IN 46202, USA. glehman@iupui.edu
authors.forename: Glen A
authors.initials: GA
authors.lastname: Lehman
mesh_terms: D016587:Antimutagenic Agents / Q000627:therapeutic use*; D001672:Biocompatible Materials / Q000266:history / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004943:Esophagogastric Junction / Q000473:pathology / Q000601:surgery*; D005764:Gastroesophageal Reflux / Q000266:history / Q000601:surgery*; D005773:Gastroscopy / Q000266:history / Q000379:methods; D049673:History, 20th Century; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000627:therapeutic use*; D007267:Injections; D019904:Polymethyl Methacrylate / Q000627:therapeutic use*; D019736:Prostheses and Implants / Q000266:history / Q000639:trends*; D019919:Prosthesis Implantation / Q000266:history / Q000379:methods
chemical_list: D016587:Antimutagenic Agents; D001672:Biocompatible Materials; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D019904:Polymethyl Methacrylate