Genetics and genomics of behavioral and psychiatric disorders.
Psychiatric conditions are to some degree under genetic influences. Despite the application of advanced genetic and molecular biological technologies, the genetic bases of the human behavioral traits and psychiatric diseases remains largely unresolved. Conventional genetic linkage approaches have not yielded definitive results, possibly because of the absence of objective diagnostic tests, the complex nature of human behavior or the incomplete penetrance of psychiatric traits. However, recent studies have revealed some genes of interest using multifaceted approaches to overcome these challenges. The approaches include using families in which specific behaviors segregate as a mendelian trait, utilization of endophenotypes as biological intermediate traits, identification of psychiatric disease phenotypes in genomic disorders, and the establishment of mouse models.
Inoue
Ken
K
Departments of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Rm 604B, Houston, Texas 77030, USA. kinoue@bcm.tmc.edu
Lupski
James R
JR
D000818:Animals; D001526:Behavioral Symptoms / Q000235:genetics*; D015415:Biomarkers; D004195:Disease Models, Animal; D005824:Genetics, Behavioral; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D051379:Mice; D010641:Phenotype
D015415:Biomarkers