title: Altered T helper responses in CD40 and interleukin-12 deficient mice reveal a critical role for Th1 responses in eliminating the helminth parasite Taenia crassiceps.
abstract: A key feature of helminth infections is the induction of strong Th2-biased immune responses in their hosts. We have previously found that Th2-like responses mediate susceptibility to the helminth parasite Taenia crassiceps, probably by inhibiting Th1 responses required for the development of protective immunity against this parasite. Here we show that mice lacking interleukin-12p35 (IL-12p35-/-) following T. crassiceps infection, failed to mount a Th1 response, but developed a strong Th2-type response, produced higher levels of IgG1, IgE, interleukin-4, interleukin-5 as well as interleukin-13 than wild-type mice, and became highly susceptible to the larval stage of this cestode. In contrast, similarly-infected CD40 deficient BALB/c mice (CD40-/-) displayed impairment of both Th1 and Th2-type responses associated with low levels of interferon-gamma as well as IgE, interleukin-4, interleukin-5 and interleukin-13, but efficiently controlled T. crassiceps infection. Together, these findings suggest a detrimental role for Th2-biased responses during the larval stage of T. crassiceps infection. Furthermore, they also suggest a pivotal role for CD40 in developing Th2-type responses.
authors.affiliation: Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano no. 1, Tlalpan, Mexico City, DF 14080, Mexico.
authors.forename: Miriam
authors.initials: M
authors.lastname: Rodríguez-Sosa
authors.forename: Abhay R
authors.initials: AR
authors.lastname: Satoskar
authors.forename: John R
authors.initials: JR
authors.lastname: David
authors.forename: Luis I
authors.initials: LI
authors.lastname: Terrazas
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D019013:CD40 Antigens / Q000235:genetics / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D005260:Female; D006790:Host-Parasite Interactions; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D018664:Interleukin-12 / Q000235:genetics / Q000276:immunology*; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D013621:Taenia / Q000502:physiology; D013622:Taeniasis / Q000276:immunology*
chemical_list: D000947:Antigens, Helminth; D019013:CD40 Antigens; D016207:Cytokines; D007074:Immunoglobulin G; D018664:Interleukin-12; D007073:Immunoglobulin E