title: Sequence and embryonic expression of collagen XVIII NC1 domain (endostatin) in the zebrafish.
abstract: Endostatin, located in the NC1 domain of the collagen XVIII, is believed to inhibit the migration and proliferation of endothelial cells (Fed. Am. Soc. Exp. Biol. J. 15 (2001) 1044) and to play a role in axon guidance in Caenorhabditis elegans (J. Cell Biol. 152 (2001) 1219). Zebrafish is an attractive vertebrate model to determine the role of endostatin and the entire molecule of collagen XVIII during vertebrate development. Therefore, we have investigated the expression pattern of COL18A1 in zebrafish embryos from the segmentation to the hatching period stages.
authors.affiliation: Institut de Biologie et Chimie des Protéines, CNRS, UMR 5086, 7 passage du Vercors, 69367 Lyon Cedex 07, France.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Haftek
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Morvan-Dubois
authors.forename: Bernard
authors.initials: B
authors.lastname: Thisse
authors.forename: Christine
authors.initials: C
authors.lastname: Thisse
authors.forename: Robert
authors.initials: R
authors.lastname: Garrone
authors.forename: Dominique
authors.initials: D
authors.lastname: Le Guellec
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D043169:Endostatins / Q000096:biosynthesis / Q000235:genetics*; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D015027:Zebrafish / Q000196:embryology* / Q000378:metabolism
chemical_list: D043169:Endostatins