Congenital leukaemia in Down Syndrome--a case report.
A 17 days old male infant, who had features of Down Syndrome, presented with fever, refusal to feed and seizures. He had papular, crusted skin lesions, moderate hepatosplenomegaly and a rapid downhill course. Peripheral blood and bone marrow aspirate showed features of acute leukaemia. Congenital Leukaemia is a rare malignancy associated with a very poor prognosis. Paradoxically, many cases of Congenital Leukaemia, especially in infants with Down Syndrome, show spontaneous remission.
Aier
Moatoshi
M
Department of Pathology, Jawaharlal Institute of Post Graduate Medical Education and Research, Pondicherry.
Zadeng
Thangura
T
Basu
Debdatta
D
Biswal
Niranjan
N
Nalini
P
P
D000208:Acute Disease; D004314:Down Syndrome / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D007938:Leukemia / Q000151:congenital* / Q000209:etiology; D008297:Male; D009196:Myeloproliferative Disorders / Q000151:congenital* / Q000209:etiology; D011379:Prognosis; D012075:Remission, Spontaneous