title: Bortezomib (millennium pharmaceuticals).
abstract: Bortezomib is a ubiquitin proteasome inhibitor under development by Millennium Pharmaceuticals (formerly LeukoSite Inc) for the potential treatment of various solid tumors [312219], [392555]. In the first quarter of 2001, Millennium initiated two phase II trials evaluating bortezomib for multiple myeloma (MM). A phase II trial in patients with chronic lymphocytic leukemia (CLL) was initiated in June 2001 [400636], [412848]. By November 2001, the agent was in a number of phase I trials and combination studies for various solid tumors, including prostate, pancreatic and colorectal carcinoma [412700], [429923], [435062], [452675]. In June 2002, bortezomib was awarded Fast Track status by the FDA [453557], and in the same month pivotal phase III trials evaluating bortezomib in MM were initiated in the US, Canada and Europe [454446].
authors.affiliation: Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, MRC 1259C, 12902 Magnolia Drive, Tampa, FL 33612-9497, USA. douqp@moffitt.usf.edu
authors.forename: Q Ping
authors.initials: QP
authors.lastname: Dou
authors.forename: Ronald H
authors.initials: RH
authors.lastname: Goldfarb