title: Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study.
abstract: The antidiabetic activity of an extract from the leaves of Lagerstroemia speciosa standardized to 1% corosolic acid (Glucosol) has been demonstrated in a randomized clinical trial involving Type II diabetics (non-insulin-dependent diabetes mellitus, NIDDM). Subjects received a daily oral dose of Glucosol and blood glucose levels were measured. Glucosol at daily dosages of 32 and 48mg for 2 weeks showed a significant reduction in the blood glucose levels. Glucosol in a soft gel capsule formulation showed a 30% decrease in blood glucose levels compared to a 20% drop seen with dry-powder filled hard gelatin capsule formulation (P<0.001), suggesting that the soft gel formulation has a better bioavailability than a dry-powder formulation.
authors.affiliation: SIBR, Inc., 4112 20th Street West, Bradenton, FL 34205, USA.
authors.forename: William V
authors.initials: WV
authors.lastname: Judy
authors.forename: Siva P
authors.initials: SP
authors.lastname: Hari
authors.forename: W W
authors.initials: WW
authors.lastname: Stogsdill
authors.forename: Janet S
authors.initials: JS
authors.lastname: Judy
authors.forename: Yousry M A
authors.initials: YM
authors.lastname: Naguib
authors.forename: Richard
authors.initials: R
authors.lastname: Passwater
mesh_terms: D000284:Administration, Oral; D000368:Aged; D001682:Biological Availability; D001786:Blood Glucose / Q000187:drug effects; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D031563:Lagerstroemia / Q000737:chemistry*; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D002214:Capsules; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D014315:Triterpenes; C113861:corosolic acid