Effect of Gymnema montanum on blood glucose, plasma insulin, and carbohydrate metabolic enzymes in alloxan-induced diabetic rats.
The effects of Gymnema montanum, an endangered plant used in the ancient period of India, on blood glucose, plasma insulin, and carbohydrate metabolic enzymes were studied in alloxan diabetic rats. Administration of alcoholic extract of G. montanum leaves (50, 100, 200 mg/kg body weight) to alloxan diabetic rats for 3 weeks reduced the blood glucose level. Administration of G. montanum leaf extract (GLEt) at 200 mg/kg body weight significantly decreased the blood glucose levels and significantly increased the plasma insulin levels. This clearly shows the antidiabetic efficacy of GLEt, which was better than that of glibenclamide.
Ananthan
Rajendran
R
Department of Botany, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India.
Latha
Muniappan
M
Pari
Leelavinothan
L
Ramkumar
Kunga Mohan
KM
Baskar
Chokkanna Gounder
CG
Bai
Vengatesh Narmatha
VN
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D050260:Carbohydrate Metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology; D006597:Fructose-Bisphosphatase / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005905:Glyburide / Q000627:therapeutic use; D006003:Glycogen / Q000378:metabolism; D031103:Gymnema / Q000737:chemistry*; D006593:Hexokinase / Q000378:metabolism; D007328:Insulin / Q000097:blood*; D008099:Liver / Q000201:enzymology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D007328:Insulin; D010936:Plant Extracts; D006003:Glycogen; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase; D005905:Glyburide