The diverse functions of histone acetyltransferase complexes.
Although histone acetylation has historically been linked to transcription activation, recent studies indicate that this modification and the enzymes that catalyze it have much broader and diverse functions. Histone acetyltransferase complexes are involved in such diverse processes as transcription activation, gene silencing, DNA repair and cell-cycle progression. The high conservation of the acetyltransferase complexes and their functions illustrates their central role in cell growth and development.
Carrozza
Michael J
MJ
Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Penn State University, University Park, PA 16803, USA. mjc28@psu.edu
Utley
Rhea T
RT
Workman
Jerry L
JL
Côté
Jacques
J
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D002467:Cell Nucleus / Q000201:enzymology; D004260:DNA Repair; D020868:Gene Silencing; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D006657:Histones; D029701:Saccharomyces cerevisiae Proteins; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases