Long-term voluntary ethanol drinking increases expression of NMDA receptor 2B subunits in rat frontal cortex.
Forced ethanol drinking for several days and application of ethanol to cell cultures changes expression levels of various NMDA receptor subunits in rodents. Therefore, we investigated the influence of long-term voluntary ethanol consumption on the expression of NMDA receptor 2B (NR2B) subunits in several forebrain regions of rats [corrected]. This result is in accordance with and extends findings from studies using high doses of ethanol for a short period and suggests that the NR2B might be a potential target for an effective treatment of alcoholic patients.
Henniger
Markus S H
MS
Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, D-80804 Munich, Germany. henninger@mpipsykl.mpg.de
Wotjak
Carsten T
CT
Hölter
Sabine M
SM
D000428:Alcohol Drinking / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000096:biosynthesis* / Q000235:genetics; D013995:Time
C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate