title: Hairy cell leukemia: an update.
abstract: Hairy cell leukemia is an indolent, chronic B-cell lymphoproliferative disorder comprising approximately 2 to 3% of all adult leukemias in the United States. Hairy cells are clonal expansions of mature, activated B-cells. They co-express CD11c, CD19, CD20, CD22, CD25, and CD103. Hairy cells possess clonal immunoglobulin gene rearrangements and express monoclonal surface immunoglobulin of either IgG or multiple heavy-chain isotypes. Treatment of hairy cell leukemia should be considered for symptomatic patients. It is indicated in patients with significant neutropenia, anemia, thrombocytopenia, symptomatic splenomegaly, constitutional symptoms due to hairy cell leukemia, or recurrent serious infections. Many treatments exist, including cladribine, pentostatin, interferon-alpha, splenectomy, rituximab (mabthera), and BL-22 immunotoxin.
authors.affiliation: Division of Hematology/Oncology, Scripps Clinic, La Jolla, California 92037, USA.
authors.forename: Grant R
authors.initials: GR
authors.lastname: Goodman
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Bethel
authors.forename: Alan
authors.initials: A
authors.lastname: Saven
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D019070:Cell Lineage; D006801:Humans; D016130:Immunophenotyping; D007943:Leukemia, Hairy Cell / Q000473:pathology* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents