Wingless signaling: an axin to grind.
Negative regulation of Wingless/Wnt signaling plays an important role in embryonic patterning and is also needed for tumor suppression in adult tissues. New findings in Drosophila reveal a novel mechanism for down-regulating the activity of the Wingless/Wnt pathway.
Jones
Whitney M
WM
Department of Biology, Duke University, B336 LSRC, Research Drive, Durham, North Carolina 27708, USA.
Bejsovec
Amy
A
D000818:Animals; D015536:Down-Regulation; D004330:Drosophila / Q000196:embryology*; D029721:Drosophila Proteins / Q000502:physiology*; D009024:Morphogenesis; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D015398:Signal Transduction; D051155:Wnt1 Protein
D029721:Drosophila Proteins; D011518:Proto-Oncogene Proteins; D051155:Wnt1 Protein; C074622:wg protein, Drosophila