title: Mesenchymal stem cells and hematopoietic stem cell transplantation.
abstract: Techniques have recently beome available to isolate and grow mesenchymal progenitors and to manipulate their growth under defined in vitro culture conditions. As a result mesenchymal stem cells can be rapidly expanded to numbers that are required for clinical application. This has allowed the clinical testing of culture-expanded MSCs in the context of hematopoietic stem cell transplantation. In this paper we discuss the role of MSCs in hematopoietic engraftment after transplantation.
authors.affiliation: Laboratory of Experimental Hematology, Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands. W.E.Fibbe@LUMC.nl
authors.forename: Willem E
authors.initials: WE
authors.lastname: Fibbe
authors.forename: Willy A
authors.initials: WA
authors.lastname: Noort
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D064987:Cell- and Tissue-Based Therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods* / Q000639:trends; D006801:Humans; D008648:Mesoderm / Q000166:cytology* / Q000276:immunology; D013234:Stem Cells / Q000166:cytology*