title: Of mice and men: phylogenetic footprinting aids the discovery of regulatory elements.
abstract: Phylogenetic footprinting is an approach to finding functionally important sequences in the genome that relies on detecting their high degrees of conservation across different species. A new study shows how much it improves the prediction of gene-regulatory elements in the human genome.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520-8114, USA.
authors.forename: Zhaolei
authors.initials: Z
authors.lastname: Zhang
authors.forename: Mark
authors.initials: M
authors.lastname: Gerstein
mesh_terms: D000818:Animals; D018983:DNA Footprinting / Q000639:trends*; D005809:Genes, Regulator / Q000235:genetics*; D006801:Humans; D051379:Mice; D010802:Phylogeny