Release from transdermal delivery systems. Application of a new non isothermic method to Trans-Ver-Sal patches.
In this paper a new non isothermic method for the determination of the release drug rate constant (k) from a transdermal delivery system is proposed. The new method was applied to transdermal patches Trans-Ver-Sal. The results obtained prove to be able to release salicylic acid of transdermal system and the effectiveness of the new method propose.
Alibrandi
G
G
Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica, Università di Messina, Messina, Italia.
Coppolino
S
S
Micali
N
N
Villari
A
A
D000279:Administration, Cutaneous; D000465:Algorithms; D002138:Calibration; D016503:Drug Delivery Systems; D020156:Salicylic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D020156:Salicylic Acid