Expedient acylations of primary and secondary alkyl cyanides to alpha-substituted beta-ketonitriles.
Primary and secondary cyanides are efficiently acylated with N-acylbenzotriazoles 3a-f (derived from a variety of acids) to afford the corresponding alpha-substituted beta-ketonitriles 5a-r in 67-96% yields.
Katritzky
Alan R
AR
Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
Abdel-Fattah
Ashraf A A
AA
Wang
Mingyi
M