title: Diffusion-weighted imaging abnormalities in the splenium after seizures.
abstract: OBJECTIVE
  Transient increased T2 signal in the splenium of the corpus callosum after seizures has been reported and sometimes attributed to a postulated toxicity of anticonvulsant medications (AEDs).
  
  
  METHODS
  We describe two patients with bitemporal epilepsy.
  
  
  RESULTS
  Transiently increased T2 signal (in one) and decreased apparent diffusion coefficient (ADC) (in both) in the splenium appeared to be related directly to acute seizures.
  
  
  CONCLUSIONS
  These cases illustrate an unusual acute postictal imaging finding, highlight involvement of an important commissural pathway, and suggest that seizures per se, and not their treatment, are the cause of transient white-matter abnormalities in these cases.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Oster
authors.forename: Colin
authors.initials: C
authors.lastname: Doherty
authors.forename: P Ellen
authors.initials: PE
authors.lastname: Grant
authors.forename: Mirela
authors.initials: M
authors.lastname: Simon
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Cole
mesh_terms: D000208:Acute Disease; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D003337:Corpus Callosum / Q000503:physiopathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D004569:Electroencephalography / Q000379:methods / Q000706:statistics & numerical data; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D005500:Follow-Up Studies; D007839:Functional Laterality; D006801:Humans; D008297:Male; D014743:Videotape Recording
chemical_list: D000927:Anticonvulsants