Effect of sustained release isosorbide dinitrate (EV151) in dogs with experimentally-induced mitral insufficiency.
To investigate the hemodynamic effects on seven anesthetized dogs with experimentally-induced mitral insufficiency, isosorbide dinitrate (ISDN) in sustained release form (EV151) was administered at different dosages (0, 2, 8 and 16 mg/kg). The drug administration resulted in altered pulmonary arterial wedge pressure (preload), and cardiac output and total systemic resistance (afterload). Arterial pressure increased in the control group and in animals receiving 2 mg/kg, but decreased in animals 1-2 hr after receiving 8 and 16 mg/kg dosages. Cardiac output increased in animals receiving 2, 8 and 16 mg/kg dosages, with concomitant decreases in total systemic resistance. ISDN caused mild vasodilation at 2 mg/kg and severe vasodilation at 8 and 16 mg/kg. Future experiments on non-anesthetized dogs may be of benefit.
Nagasawa
Yutaka
Y
Animal Clinical Research Foundation, Kurayoshi-shi, Tottori, Japan.
Takashima
Kazuaki
K
Masuda
Yuko
Y
Kataoka
Tomonori
T
Kuno
Yoshihiro
Y
Kaba
Naoki
N
Yamane
Yoshihisa
Y
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000009:adverse effects / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects*; D007548:Isosorbide Dinitrate / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D008944:Mitral Valve Insufficiency / Q000188:drug therapy* / Q000503:physiopathology / Q000662:veterinary*; D014664:Vasodilation / Q000187:drug effects
D003692:Delayed-Action Preparations; D007548:Isosorbide Dinitrate