Chronic myeloid leukemia in a patient with colon adenocarcinoma.
A 62-year-old male patient who developed Philadelphia chromosome-positive chronic myeloid leukemia (CML) after cisplatin and 5-fluorouracil treatment for colon adenocarcinoma is reported. CML has been described after therapy for other malignancies, but no case of CML has been reported following treatment for colon carcinoma. It is not clear whether the development of CML after colon adenocarcinoma represents a therapy-related secondary malignancy, a coincidence, or an increased susceptibility to secondary malignancies due to the malignant process itself. Here we reported a case with colon adenocarcinoma and later developing CML which is not reported so far in according to our knowledge.
Gokel
Yüksel
Y
Department of Emergency, Faculty of Medicine, Cukurova University, Adana, Turkey. ygokel@mail.cu.edu.tr
Paydas
Semra
S
D000230:Adenocarcinoma / Q000150:complications* / Q000188:drug therapy; D002945:Cisplatin / Q000009:adverse effects; D003110:Colonic Neoplasms / Q000150:complications* / Q000188:drug therapy; D005472:Fluorouracil / Q000009:adverse effects; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000150:complications* / Q000209:etiology
D002945:Cisplatin; D005472:Fluorouracil