title: [Bacteria of the Burkholderia cepacia complex: specific features of diagnostics, genome organization and metabolism].
abstract: Modern data, related with the identification and typing of the complex B. cepacia bacteria, are analyzed in the article by using the poly-phase taxonomic approach. An optimal scheme for identifying and typing the complex B. cepacia bacteria, involving the microbiological and molecular-biological methods of laboratory diagnostics, is presented. The key and assumed factors of pathogenicity of the discussed bacteria are described. The possible phylogenetic relations of the complex B. cepacia bacteria with phytopathgens as well as with pathogenic bacteria of species Burkholderia, Pseudomonas, Escherichia, B. mallei, B. pdeudomallei, P. seruginosa and E. coli are described. A possible role of genome alterations and mutations in the genome of the complex B. cepacia bacteria (with the latter genome having unusual properties, i.e. a big size, and a considerable quantity of insertion sequences) in creating the conditions for the "pulsing" evolution "jerks", i.e. for a rapid change-over from saprophytism in the soil to a pathogenic causative agent of a viral-and-bacteriological infection. Such mechanism can be regarded as a rapid and radical adaptation of a microorganism under the conditions of changing ecological niches.
authors.affiliation: Gamaleya's Research Institute for Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Shaginian
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Chernukha
mesh_terms: D000222:Adaptation, Physiological; D019121:Burkholderia Infections / Q000382:microbiology*; D016956:Burkholderia cepacia / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D003550:Cystic Fibrosis / Q000382:microbiology; D016680:Genome, Bacterial; D006801:Humans; D009154:Mutation; D010802:Phylogeny; D010935:Plant Diseases / Q000382:microbiology; D018410:Pneumonia, Bacterial / Q000382:microbiology; D013045:Species Specificity; D014552:Urinary Tract Infections / Q000382:microbiology