Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes.
Older age is a strong predictor of accelerated human immunodeficiency virus (HIV) disease progression. We investigated the possible immunologic basis of this interaction by comparing older (>/=45 years) and younger (</=30 years) HIV-infected adults with simultaneously enrolled, aged-matched, healthy volunteers. Cross-sectional comparisons suggested age-associated reductions in naive CD8(+) cells and in the expression of CD28(+) on CD8(+) cells among both HIV-infected subjects and control subjects. Opposite patterns of CD4(+) and CD8(+) cell differences were apparent between these subject groups. HIV infection, but not age, was associated with impairments in delayed-type hypersensitivity responses, lymphoproliferation, and spontaneous apoptosis and with alterations in expression of chemokine receptors CCR5 and CXCR4. Reduced thymic volumes were associated with age and with HIV infection among younger, but not older, subjects. Because of their common association with age and HIV disease, naive CD8(+) cell depletion, diminished CD28 expression on CD8(+) cells, and reduced thymic volumes are possible correlates of the interaction of age with HIV disease.
Kalayjian
Robert C
RC
MetroHealth Medical Center and Case Western Reserve University, Cleveland, Ohio, USA. rkalayjian@metrohealth.org
Landay
Alan
A
Pollard
Richard B
RB
Taub
Dennis D
DD
Gross
Barry H
BH
Francis
Isaac R
IR
Sevin
Anne
A
Pu
Minya
M
Spritzler
John
J
Chernoff
Miriam
M
Namkung
Ann
A
Fox
Lawrence
L
Martinez
Ana
A
Waterman
Karen
K
Fiscus
Susan A
SA
Sha
Beverly
B
Johnson
Debra
D
Slater
Stanley
S
Rousseau
Frank
F
Lederman
Michael M
MM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000276:immunology*; D018106:CD28 Antigens / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005786:Gene Expression Regulation; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology / Q000473:pathology*
D018106:CD28 Antigens