title: Congenital leukaemia in Down Syndrome--a case report.
abstract: A 17 days old male infant, who had features of Down Syndrome, presented with fever, refusal to feed and seizures. He had papular, crusted skin lesions, moderate hepatosplenomegaly and a rapid downhill course. Peripheral blood and bone marrow aspirate showed features of acute leukaemia. Congenital Leukaemia is a rare malignancy associated with a very poor prognosis. Paradoxically, many cases of Congenital Leukaemia, especially in infants with Down Syndrome, show spontaneous remission.
authors.affiliation: Department of Pathology, Jawaharlal Institute of Post Graduate Medical Education and Research, Pondicherry.
authors.forename: Moatoshi
authors.initials: M
authors.lastname: Aier
authors.forename: Thangura
authors.initials: T
authors.lastname: Zadeng
authors.forename: Debdatta
authors.initials: D
authors.lastname: Basu
authors.forename: Niranjan
authors.initials: N
authors.lastname: Biswal
authors.forename: P
authors.initials: P
authors.lastname: Nalini
mesh_terms: D000208:Acute Disease; D004314:Down Syndrome / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D007938:Leukemia / Q000151:congenital* / Q000209:etiology; D008297:Male; D009196:Myeloproliferative Disorders / Q000151:congenital* / Q000209:etiology; D011379:Prognosis; D012075:Remission, Spontaneous