title: Autism and Möbius sequence: an exploratory study of children in northeastern Brazil.
abstract: The psychiatric examination was performed with diagnostic instruments for autism (DSM-IV and Childhood Autism Rating Scale-CARS) in 23 children with Möbius sequence. From the 23 patients studied with Möbius sequence, five (26.1%) met the diagnostic criteria for infantile autism according DSM-IV and two (8.6%), under two years old, showed autistic-like behavior. The scores for six children were compatible to severe autism symptoms according CARS and one child met the criteria for moderate autism symptoms. Among five children with autism, three (60%) had positive history of misoprostol exposure during the first trimester of pregnancy and from two cases autistic-like, one (50%) had positive history of misoprostol exposure during pregnancy. According to our data, this is the first report of Möbius sequence with autism and positive history of misoprostol use during pregnancy.
authors.affiliation: Departamento de Neuropsiquiatria, Universidade Federal de Pernambuco, Recife, PE, Brasil. mbandim@uol.com.br
authors.forename: José Marcelino
authors.initials: JM
authors.lastname: Bandim
authors.forename: Liana O
authors.initials: LO
authors.lastname: Ventura
authors.forename: Marilyn T
authors.initials: MT
authors.lastname: Miller
authors.forename: Henderson C
authors.initials: HC
authors.lastname: Almeida
authors.forename: Ana Elizabeth Santos
authors.initials: AE
authors.lastname: Costa
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000009:adverse effects; D001321:Autistic Disorder / Q000139:chemically induced / Q000150:complications* / Q000175:diagnosis; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016595:Misoprostol / Q000009:adverse effects; D020331:Mobius Syndrome / Q000139:chemically induced / Q000150:complications* / Q000175:diagnosis; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011569:Psychiatric Status Rating Scales
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol