title: Conventional or physicochemical approach in intensive care unit patients with metabolic acidosis.
abstract: BACKGROUND
  Metabolic acidosis is the most frequent acid-base disorder in the intensive care unit. The optimal analysis of the underlying mechanisms is unknown.
  
  
  OBJECTIVE
  To compare the conventional approach with the physicochemical approach in quantifying complicated metabolic acidosis in patients in the intensive care unit.
  
  
  METHODS
  We included 50 consecutive patients with a metabolic acidosis (standard base excess < or = -5). We measured sodium, potassium, calcium, magnesium, chloride, lactate, creatinine, urea, phosphate, albumin, pH, and arterial carbon dioxide and oxygen tensions in every patient. We then calculated HCO3-, the base excess, the anion gap, the albumin-corrected anion gap, the apparent strong ion difference, the effective strong ion difference and the strong ion gap.
  
  
  RESULTS
  Most patients had multiple underlying mechanisms explaining the metabolic acidosis. Unmeasured strong anions were present in 98%, hyperchloremia was present in 80% and elevated lactate levels were present in 62% of patients. Calculation of the anion gap was not useful for the detection of hyperlactatemia. There was an excellent relation between the strong ion gap and the albumin-corrected and lactate-corrected anion gap (r2 = 0.934), with a bias of 1.86 and a precision of 0.96.
  
  
  CONCLUSIONS
  Multiple underlying mechanisms are present in most intensive care unit patients with a metabolic acidosis. These mechanisms are reliably determined by measuring the lactate-corrected and albumin-corrected anion gap. Calculation of the more time-consuming strong ion gap according to Stewart is therefore unnecessary.
authors.affiliation: Department of Intensive Care Medicine, University Medical Centre St Radboud, Nijmegen, The Netherlands.
authors.forename: Mirjam
authors.initials: M
authors.lastname: Moviat
authors.forename: Frank
authors.initials: F
authors.lastname: van Haren
authors.forename: Hans
authors.initials: H
authors.lastname: van der Hoeven
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000838:Anions / Q000097:blood; D001774:Blood Chemical Analysis / Q000379:methods; D002712:Chlorides / Q000097:blood; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D017064:Process Assessment, Health Care
chemical_list: D000838:Anions; D002712:Chlorides; D019344:Lactic Acid