Platelet-derived growth factor and bone morphogenetic protein in the healing of mandibular fractures in rats.
We studied the effects of platelet-derived growth factor-B (PDGF-B) and bone morphogenetic protein-2 (BMP-2) during the healing of mandibular closed fractures in rats by immunohistochemical methods. Unilateral closed fractures were created in the mandibles of thirty 12-week-old rats. BMP-2 was expressed during all stages of healing, but PDGF-B was expressed mainly in the early and middle stages, and not in the later stage of the healing process. We conclude that PDGF-B was associated with the proliferation and migration of primitive mesenchymal cells. BMP-2 was related to the differentiation of mesenchymal cells into osteoblasts and chondroblasts. PDGF-B and BMP-2 both have distinct regulatory effects on the healing of fractures.
Rasubala
L
L
Department of Oral and Maxillofacial Oncology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan. rasubala@isc.kyushu-u.ac.jp
Yoshikawa
H
H
Nagata
K
K
Iijima
T
T
Ohishi
M
M
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D019902:Chondrocytes / Q000502:physiology; D017102:Fracture Healing / Q000502:physiology*; D005596:Fractures, Closed / Q000473:pathology / Q000503:physiopathology*; D007150:Immunohistochemistry; D008297:Male; D008337:Mandibular Fractures / Q000473:pathology / Q000503:physiopathology*; D008648:Mesoderm / Q000473:pathology; D010006:Osteoblasts / Q000502:physiology; D020574:Proto-Oncogene Proteins c-sis / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000502:physiology*
C525720:Bmp2 protein, rat; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D020574:Proto-Oncogene Proteins c-sis; D016212:Transforming Growth Factor beta