title: Acute lymphoblastic leukemia presenting with lactic acidosis and renal tubular dysfunction.
abstract: Acute lymphoblastic leukemia (ALL) in children can rarely present with severe lactic acidosis in the absence of a high white blood cell count or other complications. Renal tubular dysfunction with hypercalciuria and hypocalcemia in the absence of pre-existing renal disease or concurrent medications has not been described at presentation in childhood ALL. The authors describe a 7-year-old boy with ALL presenting with severe lactic acidosis and renal tubular dysfunction, both of which were refractory to conventional management and resolved rapidly with appropriate chemotherapy.
authors.affiliation: Division of Pediatric Oncology, Department of Pediatrics, Tawam Hospital, UAE University, Al Ain, United Arab Emirates.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Hayek
authors.forename: Ashok
authors.initials: A
authors.lastname: Srinivasan
mesh_terms: D000140:Acidosis, Lactic / Q000175:diagnosis* / Q000188:drug therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002118:Calcium / Q000097:blood / Q000652:urine; D002648:Child; D004232:Diuretics; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006996:Hypocalcemia / Q000175:diagnosis; D007674:Kidney Diseases / Q000175:diagnosis* / Q000188:drug therapy; D007684:Kidney Tubules / Q000473:pathology*; D008297:Male; D010530:Peritoneal Dialysis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000188:drug therapy; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use
chemical_list: D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; D002118:Calcium