title: Characteristics of hypotension-prone haemodialysis patients: is there a critical relative blood volume?
abstract: BACKGROUND
  Intradialytic morbid events (IME, mostly hypotension) mainly due to ultrafiltration-induced hypovolaemia still are the most frequent complication during haemodialysis (HD). This study was performed to test the hypothesis that there is an individual critical relative blood volume (RBV(crit)) in IME-prone HD patients.
  
  
  METHODS
  In this prospective international multicentre study, 60 IME-prone patients from nine dialysis centres were observed during up to 21 standard HD sessions without trial-specific intervention. The RBV was monitored continuously by an ultrasonic method (BVM; blood volume monitor). Also, the ultrafiltration rate was registered continuously. Blood pressure was measured at regular intervals, and more frequently during IME. All IME and specific therapeutic interventions were noted.
  
  
  RESULTS
  In total, 537 IME, some with more than one symptom, were documented during 585 HD sessions. The occurrence of IME increased up to 10-fold from the start to the end of the HD session. RBV(crit) showed a wide inter-individual range, varying from 71 to 98%. However, the intra-individual RBV limit was relatively stable, with an SD of <5% in three-quarters of the patients. In patients with congestive heart failure, cardiac arrhythmia, advanced age, low ultrafiltration volume and low diastolic blood pressure, higher values of RBV(crit) were observed. While all correlations between RBV(crit) and patient characteristics alone were found to be of weak or medium strength, the combination of diastolic blood pressure, ultrafiltration volume and age resulted in a strong correlation with RBV(crit): the linear equation with these parameters allows an estimation of RBV(crit) in patients not yet monitored with a BVM.
  
  
  CONCLUSIONS
  An individual RBV limit exists for nearly all patients. In most IME-prone patients, these RBV values were stable with only narrow variability, thus making it a useful indicator to mark the individual window of haemodynamic instabilities.
authors.affiliation: KfH Dialysis Centre Koeln-Lindenthal, Bad Homburg, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Barth
authors.forename: Walter
authors.initials: W
authors.lastname: Boer
authors.forename: Daniela
authors.initials: D
authors.lastname: Garzoni
authors.forename: Thomas
authors.initials: T
authors.lastname: Kuenzi
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Ries
authors.forename: Ralf
authors.initials: R
authors.lastname: Schaefer
authors.forename: Daniel
authors.initials: D
authors.lastname: Schneditz
authors.forename: Theoharis
authors.initials: T
authors.lastname: Tsobanelis
authors.forename: Frank
authors.initials: F
authors.lastname: van der Sande
authors.forename: Ralf
authors.initials: R
authors.lastname: Wojke
authors.forename: Holger
authors.initials: H
authors.lastname: Schilling
authors.forename: Jutta
authors.initials: J
authors.lastname: Passlick-Deetjen
mesh_terms: D000368:Aged; D000465:Algorithms; D001810:Blood Volume / Q000502:physiology*; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007022:Hypotension / Q000209:etiology* / Q000503:physiopathology*; D020896:Hypovolemia / Q000209:etiology* / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects*; D012307:Risk Factors; D013997:Time Factors