title: Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions.
abstract: The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.
authors.affiliation: Department of Radiology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. tkawata@med.m.chiba-u.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kawata
authors.forename: Hisao
authors.initials: H
authors.lastname: Ito
authors.forename: Ken
authors.initials: K
authors.lastname: Motoori
authors.forename: Takuya
authors.initials: T
authors.lastname: Ueda
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Shigematsu
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Furusawa
authors.forename: Marco
authors.initials: M
authors.lastname: Durante
authors.forename: Kerry
authors.initials: K
authors.lastname: George
authors.forename: Honglu
authors.initials: H
authors.lastname: Wu
authors.forename: Francis A
authors.initials: FA
authors.lastname: Cucinotta
mesh_terms: D002842:Chromatids / Q000528:radiation effects; D002843:Chromatin / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000528:radiation effects*; D020450:Heavy Ions; D006801:Humans; D007501:Iron; D018499:Linear Energy Transfer
chemical_list: D002843:Chromatin; D007501:Iron