Preclinical Cushing's syndrome presenting with isolated adrenocorticotropin (ACTH) deficiency-like manifestations and severe hypoalbuminemia without overt adrenal masses in a patient with Chilaiditi syndrome and mental retardation.
A 52-year-old man with Chilaiditi syndrome and mental retardation was admitted to Kanagawa Rehabilitation Hospital for severe hypoglycemic coma with malnutrition. This patient was first diagnosed as partial isolated adrenocorticotropin deficiency according to his symptoms and clinical course, but he was finally diagnosed as preclinical Cushing's syndrome. Manifestations of this case seemed unusual in spite of autonomic cortisol secretion and the detailed mechanisms of symptoms were unclear. The present case indicates that preclinical Cushing's syndrome may present with various manifestations, and careful diagnosis is necessary.
Ikeda
Keiichi
K
Department of Internal Medicine, Kanagawa Rehabilitation Hospital, Atsugi.
Mizuguchi
Masato
M
Ebisawa
Toshihiro
T
Yoshida
Masaki
M
Uchida
Hiroyuki
H
Okabe
Hideaki
H
Sekita
Toru
T
Tojo
Katsuyoshi
K
Tajima
Naoko
N
Hosoya
Tatsuo
T
D000310:Adrenal Gland Neoplasms; D000324:Adrenocorticotropic Hormone / Q000172:deficiency*; D000740:Anemia / Q000150:complications; D003480:Cushing Syndrome / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D034141:Hypoalbuminemia / Q000097:blood / Q000150:complications*; D007003:Hypoglycemia / Q000150:complications; D008607:Intellectual Disability / Q000150:complications*; D007410:Intestinal Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009748:Nutrition Disorders / Q000150:complications
D000324:Adrenocorticotropic Hormone