title: Evaluation of a personal monitor employing an electrochemical sensor for assessing exposure to hydrogen peroxide in the workplace.
abstract: A commercially available direct-reading instrument designed for personal monitoring of vapor phase hydrogen peroxide (VHP) was evaluated in the laboratory and the workplace. Monitoring VHP has gained increasing importance in the pharmaceutical industry because sterilization using VHP has proven to be a good alternative to previously used sterilizing methods. The current Occupational Safety and Health Administration impinger method for VHP measurements, based on bubbling air through an acid solution with subsequent laboratory analysis, is not practical for monitoring personal exposures. By employing an electrochemical sensor, the instrument evaluated provides real-time exposure data with auxiliary functions such as displaying concentrations in parts per million, data logging, and alarms. A double-dilution technique using a syringe pump was used to generate dynamic test atmospheres ranging from 0.2 to 10 ppm in an exposure chamber. Time-weighted average concentration data from the direct-reading instrument was compared with concentration data from the impingers. The overall accuracy was less than the +/-25%, National Institute for Occupational Safety and Health criterion. No significant differences in accuracy were observed at three humidity levels (i.e., 15, 50, and 80%). The instrument was similarly evaluated in a workplace under typical conditions. The results agreed within +/-0.2 ppm. Selected performance characteristics of the instrument also were investigated, including reproducibility, response and recovery times, calibration frequency, and suitability of the calibration adapter. Results of the investigation suggest that the instrument provides a means for simple and accurate monitoring of personal exposures to VHP in workplace environments.
authors.affiliation: Corporate Environmental, Health, and Safety Laboratory, Abbott Laboratories, Dept. 05IH, Bldg. R1B, 1401 Sheridan Road, North Chicago, IL 60064-6259, USA.
authors.forename: Jeongim
authors.initials: J
authors.lastname: Park
authors.forename: Marcia R
authors.initials: MR
authors.lastname: Plese
authors.forename: Mark A
authors.initials: MA
authors.lastname: Puskar
mesh_terms: D000395:Air Pollutants, Occupational / Q000032:analysis*; D002138:Calibration; D004345:Drug Industry; D004563:Electrochemistry / Q000295:instrumentation; D004784:Environmental Monitoring / Q000295:instrumentation*; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis*; D015203:Reproducibility of Results; D014481:United States; D017132:Workplace
chemical_list: D000395:Air Pollutants, Occupational; D006861:Hydrogen Peroxide