Successful treatment of natural killer (NK) cell leukemia following a long-standing chronic active Epstein-Barr virus (CAEBV) infection with allogeneic bone marrow transplantation.
The optimal treatment for natural killer (NK) cell leukemia after chronic active Epstein-Barr virus (CAEBV) infection has not been determined. A 15-year-old boy presented with NK cell leukemia following CAEBV infection for 5 years. The peripheral blood and BM had an increased number of CD3(-)CD56(+) large granular lymphocytes and a monoclonal integration of the EBV genome was detected. Chemotherapy was not sufficiently effective to control the disease. Allogeneic BMT from an HLA-identical sister was performed using a conditioning regimen consisting of total body irradiation, cyclophosphamide and thiotepa. The patient is disease-free with a perfect performance status 24 months after BMT. This is the first report to show that allogeneic BMT is potentially able to cure NK cell leukemia after CAEBV infection.
Ebihara
Y
Y
Department of Pediatric Hematology/Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Manabe
A
A
Tanaka
R
R
Yoshimasu
T
T
Ishikawa
K
K
Iseki
T
T
Hayakawa
J
J
Maeda
M
M
Asano
S
S
Tsuji
K
K
D000293:Adolescent; D016026:Bone Marrow Transplantation; D004279:DNA, Viral / Q000097:blood / Q000235:genetics; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007694:Killer Cells, Natural / Q000821:virology; D007945:Leukemia, Lymphoid / Q000209:etiology* / Q000628:therapy* / Q000821:virology; D008297:Male; D014184:Transplantation, Homologous; D016662:Virus Integration
D004279:DNA, Viral