Role of pericellular proteolysis by membrane-type 1 matrix metalloproteinase in cancer invasion and angiogenesis.
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is an integral membrane proteinase that is frequently expressed in malignant cancer cells and has potent invasion-promoting activity. When expressed on the cell surface, MT1-MMP degrades the extracellular matrix (ECM) barrier adjacent to the cells to maintain the migration route to traverse the tissue. But MT1-MMP is not just an enzyme that degrades ECM. MT1-MMP also introduces limited cleavage into proteins at the cell-ECM interspaces and converts their functions. The target molecules are ECM components, cell adhesion molecules, and latent forms of MMPs. Through these processing events MT1-MMP modulates the migratory and invasive behavior of the cells.
Seiki
Motoharu
M
Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan. mseiki@ims.u-tokyo.ac.jp
Koshikawa
Naohiko
N
Yana
Ikuo
I
D000818:Animals; D002465:Cell Movement; D005109:Extracellular Matrix / Q000201:enzymology*; D006801:Humans; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases / Q000502:physiology*; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000098:blood supply / Q000201:enzymology*; D009389:Neovascularization, Pathologic / Q000201:enzymology*
D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases