Morphological and stereological characteristics of myocardial remodeling in aged spontaneously hypertensive SHR rats.
Myocardial remodeling in SHR rats with age-related hypertrophy was characterized by elimination of cardiomyocytes, their hypertrophy, and marked increase in the volume of the connective tissue. The count of cardiomyocytes with contracture injuries and subsegmental contractures increased, and pronounced perivascular and interstitial sclerosis developed in the hypertrophic myocardium of SHR rats. Damage to the microcirculatory bed manifested in degenerative changes and destruction of some endotheliocytes. Signs of atypical intracellular regeneration in myofibrils and impairment of their longitudinal orientation were revealed in cardiomyocytes in the late stage of compensatory hypertrophy.
Lushnikova
E L
EL
Laboratory of Cytology and Cell Biology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. pathol@ceber.ma.nsk.ru
Nepomnyashchikh
L M
LM
D000375:Aging / Q000502:physiology*; D000818:Animals; D008297:Male; D009206:Myocardium / Q000648:ultrastructure*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D020257:Ventricular Remodeling