title: Effect of carob bean on gastric emptying time in Thai infants.
abstract: Thickening agents, such as carob bean gum or galactomannan, have been successfully administered for the treatment of gastroesophageal reflux in infants. To study the effect of carob bean gum on gastric emptying and to symptoms of regurgitation, we recruited 20 full term Thai infants (mean age=13.4+/-7 week; mean body weight=4943+/-1272gm) without pathological gastroesophageal reflux. Initially, we determined half time gastric emptying (T 1/2 GET) by Tc99m radioscintigraphy method (mean T 1/2 GET=116.1+/-72 min) in infants consuming standard infant cow's milk formula for 2 weeks. Afterwards, carob bean infant formula was given for 2-4 weeks and weight gain, vomiting symptoms, night cough, colic, flatus, defaecation character and T 1/2 GET were assessed. There were statistically significant improvements in symptoms of vomiting (a smaller quantity P<0.001 and frequency of vomiting P<0.0001) and improvements in weight gain per week (W1=121.2+106.9gm, W2=221.3+136.1gm; P=0.005) when infants consumed the carob bean formula. However, there was no significance difference in gastric emptying half time (GET1=116.1+72, GET2=148.5+130.9; P=0.154). In conclusion, carob bean gum, as a thickening agent, improves the clinical symptoms of regurgitating infants, but does not significantly alter the gastric emptying physiology.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand. fmedbvv@md.md2.chula.ac.th
authors.forename: Boosba
authors.initials: B
authors.lastname: Vivatvakin
authors.forename: Vacharee
authors.initials: V
authors.lastname: Buachum
mesh_terms: D000930:Antidiarrheals / Q000494:pharmacology*; D005260:Female; D005685:Galactans; D005746:Gastric Emptying / Q000187:drug effects*; D005764:Gastroesophageal Reflux / Q000178:diet therapy; D006801:Humans; D007223:Infant; D007225:Infant Food; D007231:Infant, Newborn; D008297:Male; D008351:Mannans; D053149:Plant Gums; D011134:Polysaccharides / Q000494:pharmacology*; D013785:Thailand; D014783:Viscosity; D014839:Vomiting / Q000188:drug therapy*; D015430:Weight Gain
chemical_list: D000930:Antidiarrheals; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D011134:Polysaccharides; C017471:locust bean gum