Peering through the pore: nuclear pore complex structure, assembly, and function.
Nuclear pore complexes (NPCs) are large proteinaceous assemblies that provide the only known portals for exchanging macromolecules between the nucleus and cytoplasm. This includes the movement of small molecules and the selective, facilitated transport of large proteins and RNAs. Faithful, continuous NPC assembly is key for maintaining normal physiological function and is closely tied to proper cell division. This review focuses on the most outstanding issues involving NPC structure, assembly, and function.
Suntharalingam
Mythili
M
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 3120A MRBIII, 465 21st Avenue South, Nashville, TN 37232, USA.
Wente
Susan R
SR
D000818:Animals; D001693:Biological Transport, Active; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances; D008954:Models, Biological; D022022:Nuclear Pore / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism
D046911:Macromolecular Substances; D028861:Nuclear Pore Complex Proteins; D012313:RNA