Relative binding activity of new antigestagens with progesterone receptors in human hyperplastic endometrium.
We determined the content and binding capacity of progesterone receptors in the endometrium of patients with adenomatous and fibroid polyps, adenocystic hyperplasia, and atypical hyperplasia before and after gestagen therapy. Hyperplasia of the endometrium was accompanied by changes in affinity of cytosolic progesterone receptors for antigestagens, which provides the possibility of individual correction of hormone therapy.
Kamernitskii
A V
AV
Laboratory of Steroids and Terpenoids, Institute of Organic Chemistry, Russian Academy of Sciences, Moscow.
Levina
I S
IS
Kareva
E N
EN
Kirpichnikova
N V
NV
Mgdesyan
K K
KK
Ovchinnikova
E V
EV
D000077713:17 alpha-Hydroxyprogesterone Caproate; D000328:Adult; D004714:Endometrial Hyperplasia / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D020847:Estrogen Receptor Modulators / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use; D066298:In Vitro Techniques; D007700:Kinetics; D008875:Middle Aged; D011980:Receptors, Progesterone / Q000187:drug effects / Q000378:metabolism*
D020847:Estrogen Receptor Modulators; D006908:Hydroxyprogesterones; D011980:Receptors, Progesterone; D000077713:17 alpha-Hydroxyprogesterone Caproate