title: Concordant rhabdoid tumor of the kidney in a set of identical twins with discordant outcomes.
abstract: We report identical twin boys who each had stage IV rhabdoid tumor of the left kidney at the age of 5 months and 2 years, respectively. The 5-month-old boy, despite receiving chemotherapy, died of progressive disease at the age of 12 months. Following resection of the tumor, his twin brother was treated with 6 cycles of combination chemotherapy consisting of cisplatinum, doxorubicin, vincristine, cyclophosphamide, and actinomycin-D alternating with ifosfamide and etoposide. After complete regression of lung and brain metastases, he received high-dose thiotepa, etoposide, and cyclophosphamide, followed by autologous peripheral stem cell rescue. The patient is presently alive and free of disease 6 years posttransplant. High-dose chemotherapy followed by autologous stem cell transplant may be an effective front-line therapeutic approach for patients with metastatic rhabdoid tumor of the kidney.
authors.affiliation: Division of Pediatric Hematology/Oncology and Stem Cell Transplantation, Schneider Children's Hospital, Manhasset, New York 11040, USA. isahdev@lij.edu
authors.forename: Indira
authors.initials: I
authors.lastname: Sahdev
authors.forename: Angelica
authors.initials: A
authors.lastname: James-Herry
authors.forename: Philip
authors.initials: P
authors.lastname: Scimeca
authors.forename: Robert
authors.initials: R
authors.lastname: Parker
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004200:Diseases in Twins; D017809:Fatal Outcome; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000473:pathology* / Q000628:therapy; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D018335:Rhabdoid Tumor / Q000473:pathology* / Q000628:therapy; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014430:Twins, Monozygotic