Temporal lobectomy in congenital porencephaly associated with hippocampal sclerosis.
BACKGROUND
Clinical and neuroimaging features of patients with epilepsy and coexisting extratemporal porencephaly and hippocampal sclerosis have been previously described.


OBJECTIVE
To present the clinical characteristics and surgical outcome of 6 patients with intractable epilepsy and coexisting extratemporal porencephaly and hippocampal sclerosis.


METHODS
Twenty-four patients with porencephaly and epilepsy were studied. Of these, 6 had an epileptogenic focus in the temporal region. All patients underwent video electroencephalogram monitoring, magnetic resonance imaging studies, and neuropsychological evaluation. Of the subset of patients with temporal lobe epilepsy, 1 patient underwent intracranial electroencephalogram monitoring. Temporal lobe resection was performed in 5 patients. Outcomes were evaluated using the Engel classification.


RESULTS
Freedom from seizures was achieved in all patients. Pathologic analysis of the resected tissue confirmed the presurgical diagnosis of mesial temporal sclerosis.


CONCLUSIONS
Patients with extratemporal porencephaly and intractable seizures should be evaluated early and be considered for temporal lobectomy if clinical, magnetic resonance imaging, and electroencephalogram findings support the diagnosis of temporal lobe onset seizures.
Burneo
Jorge G
JG
Department of Neurology, Epilepsy Center, University of Alabama at Birmingham, 35294, USA. rkuzniecky@uabmc.edu
Faught
Edward
E
Knowlton
Robert C
RC
Martin
Roy C
RC
Bebin
Martina
M
Morawetz
Richard
R
Kuzniecky
Ruben
R
D000293:Adolescent; D000328:Adult; D001927:Brain Diseases / Q000151:congenital / Q000601:surgery*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000601:surgery*; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures; D012598:Sclerosis; D013702:Temporal Lobe / Q000601:surgery*; D016896:Treatment Outcome