title: Chronic active VZV infection manifesting as zoster sine herpete, zoster paresis and myelopathy.
abstract: After lumbar-distribution zoster, an HTLV-1-seropositive woman developed chronic radicular sacral-distribution pain (zoster sine herpete), cervical-distribution zoster paresis and thoracic-distribution myelopathy. Detection of anti-varicella zoster virus (VZV) IgM and VZV IgG antibody in cerebrospinal fluid (CSF), with reduced serum/CSF ratios of anti-VZV IgG compared to normal serum/CSF ratios for albumin and total IgG, proved that VZV caused the protracted neurological complications. Diagnosis by antibody testing led to aggressive antiviral treatment and a favorable outcome.
authors.affiliation: Department of Medicine and Geriatrics, Kochi Medical School, Kochi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Morita
authors.forename: Y
authors.initials: Y
authors.lastname: Osaki
authors.forename: Y
authors.initials: Y
authors.lastname: Doi
authors.forename: B
authors.initials: B
authors.lastname: Forghani
authors.forename: D H
authors.initials: DH
authors.lastname: Gilden
mesh_terms: D002908:Chronic Disease; D005260:Female; D015481:HTLV-I Antibodies / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D006562:Herpes Zoster / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications* / Q000821:virology; D014645:Herpesvirus 3, Human; D006801:Humans; D008875:Middle Aged; D010291:Paresis / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000821:virology; D013118:Spinal Cord Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000821:virology; D013997:Time Factors; D031368:Zoster Sine Herpete / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology* / Q000821:virology
chemical_list: D015481:HTLV-I Antibodies