[Morphological changes of collagen fibrils during the formation of autogenous tendon induced by human hair keratin artificial tendon].
OBJECTIVE
To observe the morphological changes of collagen fibrils during the formation of autogenous tendon induced by human hair keratin (HHK) artificial tendon.


METHODS
Rabbit models of injured tendon were established in which implantation of HHK artificial tendon was performed to observe the formation of autogenous tendon under light microscope and electron microscope at 3, 6, 9, 12 and 16 weeks after HHK implantation.


CONCLUSIONS
During autogenous tendon formation induced by HHK artificial tendon, the tendon cells of the impaired end of the tendon and beneath the tendon membrane dedifferentiate and are capable of collagen secretion, followed by the formation of typesI,II and III collagen fibrils, and eventually, the majority of the tendon cells disappear with the collagenization of the tendon.
Wang
Qi-wei
QW
Department of Histology and Embryology, First Military Medical University, Guangzhou 510515, China. wangqiwei2001@yahoo.com.cn
Piao
Ying-jie
YJ
Wang
Wan-shan
WS
Lu
Yan-meng
YM
Fu
Wen-yu
WY
D000818:Animals; D005260:Female; D024022:Fibrillar Collagens / Q000378:metabolism*; D006197:Hair / Q000378:metabolism; D006801:Humans; D007633:Keratins / Q000008:administration & dosage*; D008297:Male; D019736:Prostheses and Implants; D011817:Rabbits; D013710:Tendons / Q000166:cytology* / Q000601:surgery* / Q000648:ultrastructure
D024022:Fibrillar Collagens; D007633:Keratins