title: Molecular recognition of alpha,beta-unsaturated carbonyl compounds using aluminum tris(2,6-diphenylphenoxide) (ATPH): structural and conformational analysis of ATPH complexes and application to the selective vinylogous aldol reaction.
abstract: Various alpha,beta-unsaturated carbonyl compounds were coordinated with aluminum tris(2,6-diphenylphenoxide) (ATPH) to give the corresponding Lewis acid-base complexes in a distinctive coordination fashion (selective coordination). ATPH recognizes carbonyl substrates and subsequently orients itself as it forms a stable complex through selective coordination with the carbonyl oxygen. Selective coordination also confers a conformational preference to each carbonyl compound under the steric and electronic influence of ATPH, which enables the vinylogous aldol reaction of alpha,beta-unsaturated carbonyl compounds to give the corresponding gamma-aldol products with different regio- and stereoselectivities.
authors.affiliation: Graduate School of Science and Institute for Advanced Research, Nagoya University, SORST, Japan Science and Technology Corporation (JST), Chikusa, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Saito
authors.forename: Takashi
authors.initials: T
authors.lastname: Nagahara
authors.forename: Masahito
authors.initials: M
authors.lastname: Shiozawa
authors.forename: Masakazu
authors.initials: M
authors.lastname: Nakadai
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamamoto