title: Comparison of clinical and echocardiographic outcomes after valve repair: degenerative versus rheumatic mitral regurgitation.
abstract: We compared clinical (30+/-24 months) and echocardiographic follow-up (22 +/- 20 months) data of 184 consecutive patients with myxomatous degenerative mitral regurgitation (Group A) and 85 consecutive patients with rheumatic mitral regurgitation (Group B) after repair. Selection criteria for rheumatic etiology was predominant mitral regurgitation with valve area >or= 2.0 cm(2) and with no significant calcification in valvular apparatus. Repair was successful in 93% of group A and in 92% of group B (p>0.05). There was no difference of operative mortality (1% vs 0%) and of the incidence of the second-pump valve replacement (4% vs 5%). The 4-yr survival, 4-yr event-free survival, and 4-yr mitral regurgitation-free survival rates in group A were 96 +/- 2%, 89 +/- 4%, and 76 +/- 5%, respectively, which were not different from those in group B (97 +/-2 %, 93 +/- 4%, and 68 +/-7 %, p >0.05). Independent determinants of development of at least moderate regurgitation in group A were no use of ring annuloplasty (hazards ratio 6.6, 95% CI 2.0 to 21.5) and new chordae formation (hazards ratio 3.5, 95% CI 1.4 to 8.7). In group B, no use of ring annuloplasty (hazards ratio 15.3, 95% CI 3.5 to 66.7) also was independent predictor. Valve repair is highly feasible in selected patients with rheumatic mitral regurgitation, and clinical course is not significantly different from that of patients with degenerative mitral regurgitation.
authors.affiliation: Divisions of Cardiology, Asan Medical Center University of Ulsan, College of Medicine, Seoul, Korea. jksong@www.amc.seoul.kr
authors.forename: Jae-Kwan
authors.initials: JK
authors.lastname: Song
authors.forename: Hyun-Sook
authors.initials: HS
authors.lastname: Kim
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Song
authors.forename: Duk Hyun
authors.initials: DH
authors.lastname: Kang
authors.forename: Hyun
authors.initials: H
authors.lastname: Song
authors.forename: Suk Jung
authors.initials: SJ
authors.lastname: Choo
authors.forename: Meong Gun
authors.initials: MG
authors.lastname: Song
authors.forename: Jae Won
authors.initials: JW
authors.lastname: Lee
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging* / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D012214:Rheumatic Heart Disease / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome