Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents.
Novel matrix metalloproteinase (MMP) inhibitor radiotracers, (S)-3-methyl-2-(2',3',4'-methoxybiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1a-c), (S)-3-methyl-2-(2',3',4'-fluorobiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1d-f), and (S)-3-methyl-2-(4'-nitrobiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1g), a series of substituted biphenylsulfonamide derivatives, have been synthesized for evaluation as new potential positron emission tomography (PET) cancer imaging agents.
Fei
Xiangshu
X
Department of Radiology, Indiana University School of Medicine, IN 46202, Indianapolis, USA.
Zheng
Qi Huang
QH
Liu
Xuan
X
Wang
Ji Quan
JQ
Sun
Hui Bin
HB
Mock
Bruce H
BH
Stone
K Lee
KL
Miller
Kathy D
KD
Sledge
George W
GW
Hutchins
Gary D
GD
D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D007202:Indicators and Reagents; D007553:Isotope Labeling; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D053509:Matrix Metalloproteinase 13; D061965:Matrix Metalloproteinase Inhibitors; D008968:Molecular Conformation; D009369:Neoplasms / Q000000981:diagnostic imaging*; D011480:Protease Inhibitors / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014055:Tomography, Emission-Computed
D001713:Biphenyl Compounds; D007202:Indicators and Reagents; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D019275:Radiopharmaceuticals; D013449:Sulfonamides; D053509:Matrix Metalloproteinase 13