Wrightiamines A and B, two new cytotoxic pregnane alkaloids from Wrightia javanica.
Two new pregnane alkaloids, wrightiamines A (1) and B (2), were isolated from the extract of the tropical Apocynaceous plant Wrightia javanica collected in Thailand, and their structures were elucidated by spectral data. Wrightiamine B (2) was preparaed from 3beta-hydroxy-5alpha-pregnan-20-one to establish the configuration of the C-20 position as S. Wrightiamine A (1) exhibited cytotoxic activity against vincristine-resistant murine leukemia P388 cells.
Kawamoto
Souichi
S
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Koyano
Takashi
T
Kowithayakorn
Thaworn
T
Fujimoto
Haruhiro
H
Okuyama
Emi
E
Hayashi
Masahiko
M
Komiyama
Kanki
K
Ishibashi
Masami
M
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D011278:Pregnanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010936:Plant Extracts; D011278:Pregnanes; C480247:wrightiamine A; C480248:wrightiamine B