title: Bile duct cancer developing 21 years after choledochoduodenostomy.
abstract: BACKGROUND
  Cholangiocarcinoma in patients with choledochoenterostomy has been a rare condition with few cases reported in the literature written in English, and there have been few pathological descriptions of this disease. However, it has recently been documented as a late complication of choledochoenteric anastomosis, and has become a serious issue today since choledochoenterostomy and sphincteroplasty for benign biliary lesions were frequently resorted to in the 1970s and 1980s. The authors here present a case of a 67-year-old woman who developed a cholangiocarcinoma 21 years after choledochoduodenostomy.
  
  
  METHODS
  The patient underwent a curative resection of the tumor with a hepatopancreatoduodenectomy after a detailed preoperative assessment, including cholangiography and cholangioscopy.
  
  
  RESULTS
  Although this tumor has been reported to have a poor prognosis, a precise preoperative evaluation and aggressive surgery may contribute to better survival. Pathologically, the tumor originated in the bile duct mucosa of the choledochoduodenostomy, and was accompanied by intestinal and pyloric gland-like metaplasia.
  
  
  CONCLUSIONS
  These epithelial changes presumably induced by chronic inflammation due to the reflux of intestinal contents and bile stasis may be responsible for the carcinogenesis.
authors.affiliation: Department of Surgery, Anjo-Kosei Hospital, Aichi, Japan. a.maeda@scchr.jp
authors.forename: Atsuyuki
authors.initials: A
authors.lastname: Maeda
authors.forename: Shumpei
authors.initials: S
authors.lastname: Yokoi
authors.forename: Takao
authors.initials: T
authors.lastname: Kunou
authors.forename: Satomi
authors.initials: S
authors.lastname: Saeki
authors.forename: Tohru
authors.initials: T
authors.lastname: Murata
authors.forename: Noriji
authors.initials: N
authors.lastname: Niinomi
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Uesaka
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology*; D000368:Aged; D018281:Cholangiocarcinoma / Q000209:etiology*; D042883:Choledocholithiasis / Q000601:surgery; D002768:Choledochostomy / Q000009:adverse effects*; D003135:Common Bile Duct / Q000473:pathology*; D005260:Female; D006801:Humans; D008679:Metaplasia / Q000209:etiology