title: Intrathecal chemotherapy for recurrent central nervous system intraocular lymphoma.
abstract: OBJECTIVE
  To report the use of intrathecal chemotherapy for two patients with recurrent central nervous system (CNS) intraocular lymphoma.
  
  
  METHODS
  Two interventional case reports.
  
  
  METHODS
  The clinical course of two patients with documented recurrent CNS intraocular lymphoma were retrospectively reviewed.
  
  
  METHODS
  Both patients had previously undergone external beam radiation therapy to the orbit and brain, as well as systemic methotrexate (MTX) and intrathecal cytarabine (Ara-C), for primary CNS intraocular lymphoma. Both patients developed recurrent CNS intraocular lymphoma and treatment involved intrathecal MTX and Ara-C delivered by means of an Ommaya reservoir.
  
  
  METHODS
  Survival and resolution of intraocular lymphoma.
  
  
  RESULTS
  Complete remission of the CNS intraocular lymphoma was seen in both patients. Both patients maintain reading visual acuity in at least one eye. Both patients remain disease free with lymphoma in remission for greater than 5 years after initial diagnosis.
  
  
  CONCLUSIONS
  Intrathecal chemotherapy for recurrent CNS intraocular lymphoma seems to be effective in preserving vision and possibly increasing survival.
authors.affiliation: University of Alabama at Birmingham, Department of Ophthalmology, 35233, USA.
authors.forename: John O
authors.initials: JO
authors.lastname: Mason
authors.forename: David H
authors.initials: DH
authors.lastname: Fischer
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D016543:Central Nervous System Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003561:Cytarabine / Q000008:administration & dosage; D018572:Disease-Free Survival; D005134:Eye Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007278:Injections, Spinal; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology
chemical_list: D003561:Cytarabine; D008727:Methotrexate