title: [Anesthetic management for a patient with multiple sclerosis at exacerbation stage under general anesthesia].
abstract: A 39-year-old woman with multiple sclerosis (MS) at exacerbation stage underwent dilatation and curettage. MS is characterized by chronic inflammation, demyelination, and gliosis in the central nervous system. Surgical stress often induces exacerbation of MS symptoms. Therefore, deep anesthesia is required for anesthetic management in cases of MS. We monitored electroencephalograph (EEG), spectral edge frequency 90 (SEF 90), spectral median frequency (SMF) and delta-amplitude for depth of anesthesia using pEEG (Dräger, Germany). In this case, anesthesia was induced with sevoflurane and gradually increased to 5% in oxygen 4 l.min-1 and maintained with sevoflurane 2-3% in 2 nitrous oxide l.min-1 and 2 l.min-1 oxygen. Surgery was completed and no spike wave was observed by pEEG monitoring during surgery. In conclusion, sevoflurane anesthesia was useful for a patient with MS during exacerbation stage.
authors.affiliation: Department of Anesthesiology and Resuscitology, Kochi Medical School, Nankoku 783-8505.
authors.forename: Koichi
authors.initials: K
authors.lastname: Yamashita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tokai
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Imazu
authors.forename: Masakazu
authors.initials: M
authors.lastname: Lee
authors.forename: Masanobu
authors.initials: M
authors.lastname: Manabe
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D004107:Dilatation and Curettage; D005260:Female; D006801:Humans; D008738:Methyl Ethers; D008991:Monitoring, Physiologic; D009103:Multiple Sclerosis / Q000150:complications*; D011247:Pregnancy; D000077149:Sevoflurane
chemical_list: D008738:Methyl Ethers; D000077149:Sevoflurane