Intrathecal chemotherapy for recurrent central nervous system intraocular lymphoma.
OBJECTIVE
To report the use of intrathecal chemotherapy for two patients with recurrent central nervous system (CNS) intraocular lymphoma.


METHODS
Two interventional case reports.


METHODS
The clinical course of two patients with documented recurrent CNS intraocular lymphoma were retrospectively reviewed.


METHODS
Both patients had previously undergone external beam radiation therapy to the orbit and brain, as well as systemic methotrexate (MTX) and intrathecal cytarabine (Ara-C), for primary CNS intraocular lymphoma. Both patients developed recurrent CNS intraocular lymphoma and treatment involved intrathecal MTX and Ara-C delivered by means of an Ommaya reservoir.


METHODS
Survival and resolution of intraocular lymphoma.


RESULTS
Complete remission of the CNS intraocular lymphoma was seen in both patients. Both patients maintain reading visual acuity in at least one eye. Both patients remain disease free with lymphoma in remission for greater than 5 years after initial diagnosis.


CONCLUSIONS
Intrathecal chemotherapy for recurrent CNS intraocular lymphoma seems to be effective in preserving vision and possibly increasing survival.
Mason
John O
JO
University of Alabama at Birmingham, Department of Ophthalmology, 35233, USA.
Fischer
David H
DH
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D016543:Central Nervous System Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003561:Cytarabine / Q000008:administration & dosage; D018572:Disease-Free Survival; D005134:Eye Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007278:Injections, Spinal; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology
D003561:Cytarabine; D008727:Methotrexate