Determination and commitment of mechanosensory hair cells.
Sound and movement are perceived through the vibration of modified ciliary bundles located on the apical surfaces of specialized mechanosensory hair cells. These hair cells derive from specific regions of the otocyst that become determined to develop initially as sensory epithelia and ultimately as either hair cells or supporting cells. The number of hair cells in an individual vertebrate is surprisingly small and the ability to replace these cells varies among different classes. The molecular and cellular factors that specify hair cell identity are not known, but the results of recent experiments have begun to identify some of the signaling pathways that play important roles in hair cell development. This review will describe recent findings related to the factors that influence the final choice of a progenitor cell to develop as a hair cell and discuss their implications for the overall development of the auditory and vestibular systems.
Kelley
Matthew W
MW
Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Room 2B-44, Rockville, MD 20850, USA. kellymt@nidcd.nih.gov
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology; D003051:Cochlea / Q000166:cytology* / Q000196:embryology*; D004848:Epithelium / Q000196:embryology / Q000294:innervation; D018507:Gene Expression Regulation, Developmental; D006198:Hair Cells, Auditory / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D008465:Mechanoreceptors / Q000166:cytology* / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology; D051880:Receptors, Notch; D014157:Transcription Factors / Q000502:physiology
D051792:Basic Helix-Loop-Helix Proteins; D008565:Membrane Proteins; D051880:Receptors, Notch; D014157:Transcription Factors; C500943:Atoh1 protein, mouse