title: Tryptase inhibitors - review of the recent patent literature.
abstract: The past several years has seen research increasingly focused around the inhibition of tryptase, a mast cell protease implicated in a myriad of pro-inflammatory responses. Although few compounds have reached the clinic, several monobasic and multibasic small molecules have emerged as promising candidates as a treatment for asthma and other allergic and inflammatory disorders. This summary reviews recent patent activity of tryptase inhibitors and briefly outlines recent tryptase inhibitor literature and clinical updates.
authors.affiliation: Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA. bnewhouse@arraybiopharma.com
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Newhouse