Intraspinal endodermal cyst: ultrastructural study of abnormal cilia.
Abnormal cilia were demonstrated in the lining epithelial cells of three cases of intraspinal endodermal (bronchogenic) cyst. The changes comprised a wide spectrum of ultrastructural abnormalities, including (a). cilia with abnormal axonemal microtubules, (b). swollen cilia, (c). compound cilia with or without excessive ciliary matrix, (d). naked cilia without limiting membrane, and (e). intracytoplasmic cilia and aggregates of microtubules. Of these, compound cilia and swollen cilia were most common. Cilia with dynein arm deficiency were not observed. Ciliary abnormalities found in the present study were very similar to those described in the bronchial epithelium of various diseases. The present findings suggest that the lining epithelium of intraspinal endodermal cyst shares similar ciliogenesis and susceptibility to abnormal ciliary formation as that of the bronchial epithelium.
Ho
Khang L
KL
Department of Pathology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, Michigan 48202, USA. khol@hfhs.org
Chitale
Dhananjay A
DA
Salama
Mohamed E
ME
D000328:Adult; D001980:Bronchi / Q000473:pathology; D001994:Bronchogenic Cyst / Q000473:pathology / Q000648:ultrastructure*; D002923:Cilia / Q000648:ultrastructure*; D003593:Cytoplasm / Q000473:pathology; D004707:Endoderm / Q000648:ultrastructure; D004848:Epithelium / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008297:Male; D013118:Spinal Cord Diseases / Q000473:pathology*