title: Urinary tract infection in febrile children with sickle cell anaemia in Ibadan, Nigeria.
abstract: A prospective study to determine the prevalence of bacteriuria and bacterial isolates in the urine of febrile children with sickle cell anaemia (SCA) was carried out at University College Hospital, Ibadan. Altogether, 171 febrile children (aged 1-15 years) with SCA and 171 age- and sex-matched controls were studied. After obtaining a history of the illness from the parents or guardians, each child was physically examined and a mid-stream urine specimen collected and subjected to microscopy and culture. The prevalence of bacteriuria in children with SCA was 21.6% compared with 15.8% in the controls. Escherichia coli and Klebsiella species were the predominant isolates from the urine, accounting for 64.9% and 18.9%, respectively, of the isolates from the SCA group and 63% and 22.2%, respectively, in the controls. In the SCA group, significant bacteriuria also occurred with other conditions such as pneumonia and osteomyelitis. Urinary tract infection (UTI) is common in children with SCA. Routine screening for it is therefore recommended during febrile illnesses. Children with fever from other overt causes, however, should not be exempted from the urine screening procedure in case there might be concomitant UTI.
authors.affiliation: Department of Paediatrics, University College Hospital, Ibadan, Nigeria. asinobia@skannet.com
authors.forename: A O
authors.initials: AO
authors.lastname: Asinobi
authors.forename: O J
authors.initials: OJ
authors.lastname: Fatunde
authors.forename: B J
authors.initials: BJ
authors.lastname: Brown
authors.forename: K
authors.initials: K
authors.lastname: Osinusi
authors.forename: N A
authors.initials: NA
authors.lastname: Fasina
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D001437:Bacteriuria / Q000150:complications / Q000453:epidemiology / Q000382:microbiology; D001772:Blood Cell Count; D002648:Child; D002675:Child, Preschool; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D005334:Fever / Q000150:complications / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D007223:Infant; D007709:Klebsiella / Q000302:isolation & purification; D008288:Malaria / Q000150:complications / Q000453:epidemiology; D008297:Male; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D014552:Urinary Tract Infections / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D014556:Urine / Q000382:microbiology