title: Simulation of pore formation in lipid bilayers by mechanical stress and electric fields.
abstract: We describe computer simulations of pore formation and membrane rupture of phospholipid bilayers under mechanical and electrical stress. On the nanosecond simulation time scale, pores are induced by a lateral pressure exceeding -200 bar or by an applied electric field of 0.5 V/nm.
authors.affiliation: Department of Biological Sciences, University of Calgary, Alberta, Canada T2N 1N4. tielman@ucalgary.ca
authors.forename: D Peter
authors.initials: DP
authors.lastname: Tieleman
authors.forename: Hari
authors.initials: H
authors.lastname: Leontiadou
authors.forename: Alan E
authors.initials: AE
authors.lastname: Mark
authors.forename: Siewert-Jan
authors.initials: SJ
authors.lastname: Marrink
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry*; D004574:Electromagnetic Fields; D008051:Lipid Bilayers / Q000737:chemistry*; D008566:Membranes / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry*; D013314:Stress, Mechanical
chemical_list: D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D015060:1,2-Dipalmitoylphosphatidylcholine; C017251:1,2-oleoylphosphatidylcholine