title: [Pilot study of coadjuvant treatment of recurrent cystitis in women by means of AM3 (Immnoferon)].
abstract: OBJECTIVE
  The aim is to evaluate the effectiveness of AM3 (Inmunoferon) in the treatment of the recurrent cystitis in women in order to know the rate of good results, previously to design a clinical trial.
  
  
  METHODS
  Twenty-four women who had been diagnosed of two cystitis episodes in the previous 6 months without cure by antibiotic treatment were admitted to the study. Standard antibiotic treatment and 3 daily grammes of AM3 was given for 9 months. Infection and irritative symptoms during micturition rate were evaluated at the inclusion date and afterwards, at the first, third, sixth and nineth month.
  
  
  RESULTS
  Nineteen patients finished the study. The infection rate decreased from 100% at the inclusion date to 26% in the first month and then it became stable about 50%. Irritative symptoms during micturition decreased from 46% at the inclusion date to a rate lower than 10% in the 4 controls running.
  
  
  CONCLUSIONS
  AM3 reduced evident urinary infection in a 50% and irritative symptoms during micturition in a 90%. Control clinical trials are needed to confirm the AM3 effects on this pathology.
authors.affiliation: Servicio de Urología, Fundación Puigvert, Barcelona.
authors.forename: F
authors.initials: F
authors.lastname: Millán Rodríguez
authors.forename: F
authors.initials: F
authors.lastname: Rousaud Barón
authors.forename: A
authors.initials: A
authors.lastname: Rousaud Barón
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000658:Amoxicillin / Q000627:therapeutic use; D002130:Calcium Phosphates / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use; D019818:Clavulanic Acid / Q000627:therapeutic use; D003556:Cystitis / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D004341:Drug Evaluation; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D005578:Fosfomycin / Q000627:therapeutic use; D006020:Glycopeptides / Q000627:therapeutic use*; D006801:Humans; D010865:Pilot Projects; D012008:Recurrence; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D016585:Vaginosis, Bacterial / Q000150:complications
chemical_list: D000276:Adjuvants, Immunologic; D002130:Calcium Phosphates; D006020:Glycopeptides; D019818:Clavulanic Acid; D005578:Fosfomycin; D002939:Ciprofloxacin; D000658:Amoxicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; C038773:Immunoferon