Efficacy of a novel, nontray, paint-on 18% carbamide peroxide whitening gel.
A double-blind, 3-week, randomized, placebo-controlled, parallel-group clinical trial was conducted to evaluate the tooth-whitening efficacy of a novel nontray, "paint-on" liquid whitening gel containing 18% carbamide peroxide (Colgate Simply White Clear Whitening Gel). Efficacy was based on measured Vita tooth-shade scores collected at baseline and after 2 and 3 weeks of product use. Eighty healthy volunteers were balanced into 2 groups based on gender, age, and shade scores (A3 or higher). The duration of product usage was 30 minutes, twice daily, for 3 weeks. Results from this clinical study showed that subjects' teeth in the liquid whitening gel-treated group exhibited an overall mean 3.84-shade improvement and a 3.5-shade difference compared with teeth in the placebo gel group (statistically significant, P < .05) after 3 weeks. Furthermore, this improvement exceeds the minimum requirement to claim "clinical efficacy" as established by the "Guidelines for the Acceptance of Peroxide-Containing Oral Hygiene Products," published by the American Dental Association in 1994. Therefore, it can be concluded that Colgate Simply White Clear Whitening Gel significantly whitens teeth.
Nathoo
Salim
S
Oral Health Clinical Services, Colgate-Palmolive Technology Center, Piscataway, New Jersey, USA.
Stewart
Bernal
B
Zhang
Yun Po
YP
Chaknis
Pat
P
Rustogi
Kedar N
KN
DeVizio
William
W
Petrone
Margaret
M
Volpe
Anthony R
AR
D000293:Adolescent; D000328:Adult; D000571:American Dental Association; D000704:Analysis of Variance; D000077463:Carbamide Peroxide; D045424:Complex Mixtures; D003742:Dental Devices, Home Care; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005782:Gels; D017408:Guidelines as Topic; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000627:therapeutic use; D010545:Peroxides / Q000627:therapeutic use; D014073:Tooth Bleaching; D014075:Tooth Discoloration / Q000188:drug therapy*; D014481:United States; D014508:Urea / Q000031:analogs & derivatives / Q000627:therapeutic use
C475021:Colgate Simply White Clear Whitening Gel; D045424:Complex Mixtures; D003802:Dentifrices; D004338:Drug Combinations; D005782:Gels; D016877:Oxidants; D010545:Peroxides; D000077463:Carbamide Peroxide; D014508:Urea