title: Influence on hazelnut oil administration on peroxidation status of erythrocytes and apolipoprotein B 100-containing lipoproteins in rabbits fed on a high cholesterol diet.
abstract: Hazelnut oil (HO) is rich in monounsaturated fatty acids (MUFA). The effect of a high cholesterol (HC) diet with and without HO on lipids and lipid peroxide levels in plasma, apolipoprotein B 100-containing lipoproteins (VLDL + LDL), and erythrocytes as well as hematological data was investigated in rabbits. A HC diet caused significant increases in lipid peroxide levels in plasma and apo B-containing lipoproteins together with histopathological atherosclerotic findings in aorta. In addition, this diet resulted in hemolytic anemia associated with increased endogenous diene conjugate (DC) levels, but H(2)O(2)-induced malondialdehyde (MDA) levels remained unchanged in erythrocytes. HO supplementation reduced lipid peroxide levels in plasma and apolipoprotein B 100-containing lipoproteins as well as aortic atherosclerotic lesions in rabbits fed an HC diet without any decreasing effect on lipid levels. In addition, HO was found to reduce hemolytic anemia together with significant decreases in DC and H(2)O(2)-induced MDA levels.
authors.affiliation: Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Capa 34093, Turkey.
authors.forename: Jale
authors.initials: J
authors.lastname: Balkan
authors.forename: Aydan
authors.initials: A
authors.lastname: Hatipoğlu
authors.forename: Gülçin
authors.initials: G
authors.lastname: Aykaç-Toker
authors.forename: Müjdat
authors.initials: M
authors.lastname: Uysal
mesh_terms: D000743:Anemia, Hemolytic / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D001011:Aorta / Q000473:pathology; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000097:blood; D001161:Arteriosclerosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D031211:Corylus / Q000737:chemistry*; D004730:Endothelium, Vascular / Q000473:pathology; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000737:chemistry*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006861:Hydrogen Peroxide / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010938:Plant Oils / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits
chemical_list: D053299:Apolipoprotein B-100; D001055:Apolipoproteins B; D002791:Cholesterol, Dietary; D006454:Hemoglobins; D008054:Lipid Peroxides; D008074:Lipoproteins; D010938:Plant Oils; D008315:Malondialdehyde; D006861:Hydrogen Peroxide