Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene.
MicroRNAs (miRNAs) are an abundant class of RNAs that are approximately 21-25 nucleotides (nt) long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA interference, RNAi) depending on the degree of complementarity with their targets. Here we show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele.
Seitz
Hervé
H
LBME, Centre National de la Recherche Scientifique, UMR 5099, IFR 109, Université P. Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France.
Youngson
Neil
N
Lin
Shau-Ping
SP
Dalbert
Simone
S
Paulsen
Martina
M
Bachellerie
Jean-Pierre
JP
Ferguson-Smith
Anne C
AC
Cavaillé
Jérôme
J
D000818:Animals; D001483:Base Sequence; D002875:Chromosomes / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D008969:Molecular Sequence Data; D016372:RNA, Antisense / Q000235:genetics*; D022661:RNA, Untranslated; D018626:Retroelements / Q000235:genetics*
D008565:Membrane Proteins; D035683:MicroRNAs; D016372:RNA, Antisense; D022661:RNA, Untranslated; D018626:Retroelements