title: Light-induced modulation of self-assembly on spiropyran-capped gold nanoparticles: a potential system for the controlled release of amino acid derivatives.
abstract: A photoswitchable double-shell structure on Au nanoparticles, consisting of photochromic spiropyran as the first shell, which regulates the assembly and release of an outer shell of amino acid derivatives upon irradiation, is being reported for the first time. The light-regulated changes in the topographic properties of spiropyran-capped Au nanoparticles (i.e., interconversion between the zwitterionic and neutral forms) are exploited for the assembly and release of amino acid-based therapeutic agents such as l-DOPA.
authors.affiliation: Photosciences and Photonics Division, Regional Research Laboratory (CSIR), Trivandrum 695 019, India.
authors.forename: Binil Itty
authors.initials: BI
authors.lastname: Ipe
authors.forename: S
authors.initials: S
authors.lastname: Mahima
authors.forename: K George
authors.initials: KG
authors.lastname: Thomas
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001578:Benzopyrans / Q000737:chemistry*; D003692:Delayed-Action Preparations; D006046:Gold / Q000737:chemistry*; D007211:Indoles; D007980:Levodopa / Q000737:chemistry; D008027:Light; D009574:Nitro Compounds; D010316:Particle Size; D010777:Photochemistry; D013050:Spectrometry, Fluorescence; D014364:Tryptophan / Q000737:chemistry; D014443:Tyrosine / Q000737:chemistry
chemical_list: D000596:Amino Acids; D001578:Benzopyrans; D003692:Delayed-Action Preparations; D007211:Indoles; D009574:Nitro Compounds; C088184:spiropyran; D014443:Tyrosine; D007980:Levodopa; D006046:Gold; D014364:Tryptophan