title: Ruthenium complexes carrying a disialo complex-type oligosaccharide: enzymatic synthesis and its application to a luminescent probe to detect influenza viruses.
abstract: Tris-bipyridine ruthenium-complexes carrying a disialo complex-type oligosaccharide were prepared via a one-pot transglycosylation using endo-glycosidase (Endo M); they bind to type-A influenza viruses with excellent affinity (IC50 = 8.4 microM), and their luminescence intensity is strongly depressed by virus-binding.
authors.affiliation: Department of Molecular Design, Graduate School of Engineering, Nagoya University, Nagoya 464-8603, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kojima
authors.forename: Teruaki
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yonemura
authors.forename: Ken
authors.initials: K
authors.lastname: Sasaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Makimura
authors.forename: Tadanobu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Kazukiyo
authors.initials: K
authors.lastname: Kobayashi
mesh_terms: D004798:Enzymes / Q000737:chemistry*; D049449:Luminescence; D015335:Molecular Probes; D009844:Oligosaccharides / Q000737:chemistry*; D009975:Orthomyxoviridae / Q000302:isolation & purification*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D004798:Enzymes; D015335:Molecular Probes; D009844:Oligosaccharides; D012428:Ruthenium