title: Effects of lactate/pyruvate on synaptic plasticity in the hippocampal dentate gyrus.
abstract: The present study was undertaken to investigate whether monocarboxylates (lactate and pyruvate) can support synaptic plasticity. As an index of synaptic activity, population spikes (PS) were recorded in the hippocampal dentate gyrus. Replacement of glucose with monocarboxylates maintained PS after transient depression, and supported a similar degree of paired-pulse facilitation (PPF). Monocarboxylates-supported long-term potentiation (LTP), but the degree of enhancement was less than that of glucose-supported PS. Monocarboxylates failed to support long-term depression (LTD). These results indicate that monocarboxylates could serve as sufficient substrates for PPF, and that they could also support LTP but with less efficiency than glucose.
authors.affiliation: Department of Internal and Geriatric Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakurai
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Takata
authors.forename: Koichi
authors.initials: K
authors.lastname: Yokono
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D018891:Dentate Gyrus / Q000187:drug effects* / Q000502:physiology; D005947:Glucose / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D019344:Lactic Acid / Q000494:pharmacology*; D009473:Neuronal Plasticity / Q000187:drug effects* / Q000502:physiology; D019289:Pyruvic Acid / Q000494:pharmacology*
chemical_list: D019344:Lactic Acid; D019289:Pyruvic Acid; D005947:Glucose