Metabolic effects of D-psicose in rats: studies on faecal and urinary excretion and caecal fermentation.
D-psicose (D -ribo-2-hexulose), a C-3 epimer of D-fructose, is one of the "rare sugars" present in small quantities in commercial carbohydrate complex or agricultural products. We investigated the absorption and excretion of D-psicose when orally administrated (5g/kg body weight) to Wistar rats, and the fermentation of D-psicose was measured as caecal short-chain fatty acids (SCFAs) when fed to rats in controlled diets (0, 10, 20 and 30%). Urinary and faecal excretions of D-psicose over the 24 h, following a single oral administration, were 11-15% of dosage for the former and 8-13% of dosage for the latter. Serum D-psicose concentration and D-psicose in the contents of stomach and small intestines decreased progressively after administration. D-psicose in caecum contents was detected after 3h and 7h administration, but not after 1h. Rats fed on D-psicose diets showed short-chain fatty acid production with caecal hypertrophy. These results suggest that D-psicose is partly absorbable in the digestive tract and is excreted into urine and faeces. As with other poorly absorbed dietary carbohydrates, D-psicose is fermented in the caecum by intestinal microflora.
Matsuo
Tatsuhiro
T
Faculty of Agriculture, Kagawa University, Ikenobe, Miki-cho, Kita-gun, Kagawa, Japan. matsuo@ag.kagawa-u.ac.jp
Tanaka
Tomohiro
T
Hashiguchi
Mineo
M
Izumori
Ken
K
Suzuki
Hiroo
H
D000284:Administration, Oral; D000818:Animals; D002432:Cecum / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005232:Fatty Acids, Volatile / Q000378:metabolism; D005243:Feces / Q000737:chemistry*; D005285:Fermentation; D005632:Fructose / Q000378:metabolism / Q000493:pharmacokinetics* / Q000652:urine; D007408:Intestinal Absorption; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D005232:Fatty Acids, Volatile; C003243:psicose; D005632:Fructose