Recent applications of bifunctional trityl groups.
Triphenylmethyl derivatives represent an important class of dyestuffs as well as a useful family of protecting groups widely used in organic synthesis to transiently block various functional moieties. These applications are well documented and have been a subject of a number of reviews. Here we focus instead on some novel applications of a trityl which make good use of its ability to easily form a stabilised cation in combination with additional peripheral functionalities. Topics covered include applications in bioconjugation, cross-linking, mass-spectrometry, fluorescence and optics.
Shchepinov
M S
MS
Tridend Technologies, Hirsch Building, Begbroke Business & Science Park, Sandy Lane, Yarnton, Oxford, UK OX5 1PF. misha@tridend.com
Korshun
V A
VA
D020650:Combinatorial Chemistry Techniques / Q000379:methods; D005456:Fluorescent Dyes / Q000737:chemistry; D013058:Mass Spectrometry / Q000379:methods; D009841:Oligonucleotides / Q000138:chemical synthesis; D011355:Prodrugs / Q000138:chemical synthesis; D014320:Triphenylmethyl Compounds / Q000737:chemistry*
D005456:Fluorescent Dyes; D009841:Oligonucleotides; D011355:Prodrugs; D014320:Triphenylmethyl Compounds