(+/-)-2-(3-Piperidyl)-1,2,3,4-tetrahydroisoquinolines as a new class of specific bradycardic agents.
A series of (+/-)-2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinolines were prepared and their bradycardic activities were examined in isolated guinea-pigs' right atria and in anesthetized rats. Modifications on the benzyl moiety of the parent compound, 1, led to the identification of compound 11e as a potent and specific bradycardic agent.
Kubota
Hideki
H
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd., 21Miyukigaoka, Tsukuba, 305-8585, Ibaraki, Japan.
Kakefuda
Akio
A
Watanabe
Toshihiro
T
Taguchi
Yasuko
Y
Ishii
Noe
N
Masuda
Noriyuki
N
Sakamoto
Shuichi
S
Tsukamoto
Shin ichi
Si
D000758:Anesthesia; D000818:Animals; D001919:Bradycardia / Q000188:drug therapy*; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D051381:Rats; D013329:Structure-Activity Relationship; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology*
D002317:Cardiovascular Agents; D007202:Indicators and Reagents; D044005:Tetrahydroisoquinolines