Spontaneous remission of a massive CNS inflammation with eosinophilic infiltrate.
We report a case of spontaneous remission of a massive CNS lesion with eosinophilic infiltrate. This 69-year-old man had eosinophilia without any systemic disorder or laboratory evidence of the most common causes of hypereosinophilia. MRI of the brain suggested an infiltrating neoplasm, but histological examination of a needle biopsy specimen failed to show evidence of a neoplasm. Instead, the tissue demonstrated rarefaction and gliosis with striking perivascular and parenchymal infiltrates of eosinophils. The MRI abnormality and eosinophilia disappeared spontaneously. We speculate that eosinophil-derived neurotoxins might have been the cause of the transient CNS disorder observed in this patient.
Tamaru
Yoshiko
Y
Department of Neurology, Kitano Hospital, Osaka.
Nakashita
Mayumi
M
Ito
Hidefumi
H
Okumura
Ryosuke
R
Matsumoto
Sadayuki
S
Imai
Terukuni
T
D000368:Aged; D004660:Encephalitis / Q000175:diagnosis* / Q000209:etiology*; D004802:Eosinophilia / Q000150:complications* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012075:Remission, Spontaneous