Culture and immunohistochemical evidence of Chlamydia pneumoniae infection in ulcerative pyoderma gangrenosum.
A potentially contributing factor to the development and chronicity of pyoderma gangrenosum is infection with the relatively recently characterized human pathogen, Chlamydia pneumoniae. C pneumoniae is an obligate intracellular bacterium that can infect endothelial, monocyte, and smooth muscle cells and is associated with cardiopulmonary diseases. A case of serologically, polymerase chain reaction-positive, immunohistochemically, and culture-documented viable C pneumoniae organisms in a chronic pyoderma gangrenosum ulcer is reported, a finding that has not been described previously.
Sams
Hunter H
HH
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennesses, USA.
Mitchell
William M
WM
Stratton
Charles W
CW
King
Lloyd E
LE
D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D023521:Chlamydophila Infections / Q000150:complications* / Q000378:metabolism; D016993:Chlamydophila pneumoniae / Q000276:immunology; D002908:Chronic Disease; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D017511:Pyoderma Gangrenosum / Q000378:metabolism / Q000382:microbiology*
D000907:Antibodies, Bacterial