[The Autonomic Nervous Activity in Patients with Essential Hypertension who Showed Early Morning Rise of Blood Pressure].
Autonomic nervous function was evaluated by means of power spectral analysis of   heart rate variability in patients with essential hypertension who showed early morning rise of blood pressure (BP). We monitored ambulatory (BP) and physical activity in 80 untreated patients using TM 2425 (A&D Co.Ltd.). Early morning rise of  BP was defined a patient's blood pressure obtained between 6:00 to 9:00am is 170mmHg or higher. Patients who showed early morning rise of BP were categorized into groups. Twenty patients, whose mean BP obtained between 6:00 to 9:00am were  higher than those obtained between 3:00 to 600am by 30mmHg or more, were defined as a surge type. Sixty patients, in whom the difference in BP was less than 30mmHg, were defined as a sustained type. Power spectral analysis of   hourly R-R intervals for 24 hours was performed to obtain the low frequency power (LF, 0.04 to 0.15 Hz) and high frequency power (HF, 0.15 to0.04 Hz).  LFn and LF/HF ratio were considered to  be indexes of sympathetic nervous activity, and HF parasympathetic nervous activity, respectively. Between 3:00 to 6:00am, LFn and LF/HF were  significantly higher and HF was significantly lower in the sustained  type patients than in the surge type patients. LF/HF and LFn in the surge type elevated  significantly beween 6:00 to 9:00am. These results indicate that both the loss of nocturnal decline in BP in the sustained type and the morning rise in BP in the surge type to occurred in association with changes in autonomic nervous system.
Ohisa
Noriko
N
Department of Clinical Laboratory, Tohoku University Hospital, Sendai 980-8574.
Yoshida
Katsumi
K
Kaku
Mitsuo
M
D000328:Adult; D000368:Aged; D001341:Autonomic Nervous System / Q000503:physiopathology*; D001794:Blood Pressure; D002940:Circadian Rhythm; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged