title: Central, but not peripheral, glucagon-like peptide-1 inhibits crop emptying in chicks.
abstract: We investigated the effect of central and peripheral glucagon-like peptide-1 (GLP-1) on crop emptying in growing chicks. Intracerebroventricular injection of two concentrations of GLP-1 (15 and 60 pmol) similarly suppressed crop emptying, compared with control chicks. The delay in crop emptying induced by GLP-1 (15 pmol) was partly attenuated by co-administration with exendin (5-39) (600 pmol), a GLP-1 receptor antagonist, although exendin (5-39) alone did not affect crop emptying. On the other hand, intraperitoneal administration of several doses of GLP-1 (120, 300 and 3000 pmol) did not alter crop emptying. The present study revealed that central, but not peripheral, GLP-1 inhibits crop emptying in chicks.
authors.affiliation: United Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan. tetsu@brs.kyushu-u.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tachibana
authors.forename: Mako
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Furuse
authors.forename: Shin
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Yoshizawa
authors.forename: Kunio
authors.initials: K
authors.lastname: Sugahara
mesh_terms: D000818:Animals; D002645:Chickens / Q000502:physiology*; D003426:Crop, Avian / Q000187:drug effects* / Q000502:physiology; D005934:Glucagon / Q000494:pharmacology*; D052216:Glucagon-Like Peptide 1; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D010446:Peptide Fragments / Q000494:pharmacology*; D011498:Protein Precursors / Q000494:pharmacology*
chemical_list: D010446:Peptide Fragments; D011498:Protein Precursors; D052216:Glucagon-Like Peptide 1; D005934:Glucagon