Bromocriptine augmentation therapy in a patient with Cotard's syndrome.
A 72-year-old female with bipolar I disorder developed Cotard's syndrome, i.e., various delusions of negation accompanied by severe depressive symptoms. She responded neither to the combination of antipsychotic drug and antidepressant nor to the lithium augmentation therapy. However, the delusions and depressive symptoms improved dramatically after the addition of bromocriptine 2.5-5 mg/day to the combination of clomipramine and lithium. This report suggests that bromocriptine augmentation therapy might be effective at least for some patients with Cotard's syndrome in mood disorders.
Kondo
Shuko
S
Department of Neuropsychiatry, Yamagata University School of Medicine, 990-9585, Yamagata, Japan. otani@med.id.yamagata-u.ac.jp
Hayashi
Hiroshi
H
Eguchi
Takuya
T
Oyama
Takanobu
T
Wada
Tadashi
T
Otani
Koichi
K
D000368:Aged; D001714:Bipolar Disorder / Q000150:complications* / Q000188:drug therapy*; D001971:Bromocriptine / Q000008:administration & dosage / Q000494:pharmacology*; D003702:Delusions / Q000188:drug therapy* / Q000209:etiology; D003863:Depression / Q000188:drug therapy* / Q000209:etiology; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D013577:Syndrome; D016896:Treatment Outcome
D018491:Dopamine Agonists; D001971:Bromocriptine