title: Squamous cell carcinoma developing in a 12-year-old boy with nonHallopeau-Siemens recessive dystrophic epidermolysis bullosa.
abstract: We report a 12-year-old boy with nonHallopeau-Siemens recessive dystrophic epidermolysis bullosa (nHS-RDEB) who developed two skin lesions of squamous cell carcinoma (SCC) on the left foot. The incidence of SCC in nHS-RDEB is much lower than in the HS-RDEB subtype. Furthermore, this boy is the youngest among 92 previously described patients with DEB to develop SCC. This study emphasizes the importance of vigilance in monitoring the possible development of SCC in DEB patients regardless of age or clinical severity.
authors.affiliation: Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7 Kita-ku, Sapporo 060-8638, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kawasaki
authors.forename: D
authors.initials: D
authors.lastname: Sawamura
authors.forename: F
authors.initials: F
authors.lastname: Iwao
authors.forename: T
authors.initials: T
authors.lastname: Kikuchi
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Okubo
authors.forename: T
authors.initials: T
authors.lastname: Matsumura
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
mesh_terms: D017668:Age of Onset; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000235:genetics / Q000473:pathology; D002648:Child; D018389:Codon, Nonsense; D024143:Collagen Type VII / Q000235:genetics; D016110:Epidermolysis Bullosa Simplex / Q000150:complications* / Q000235:genetics / Q000473:pathology; D005534:Foot Diseases / Q000150:complications* / Q000235:genetics / Q000473:pathology; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D012878:Skin Neoplasms / Q000150:complications* / Q000235:genetics / Q000473:pathology
chemical_list: D018389:Codon, Nonsense; D024143:Collagen Type VII