Effects of pregnancy on the renal and pulmonary manifestations in women with tuberous sclerosis complex.
OBJECTIVE
To determine whether pregnancy increases the risk of renal or pulmonary complications in women with tuberous sclerosis complex (TSC).


METHODS
We surveyed female members of the Tuberous Sclerosis Alliance and reviewed the files of adult women seen in our genetics clinics for complications of TSC.


RESULTS
Among 145 individuals, there was no significant difference in incidence of renal and pulmonary involvement between the pregnant and never-pregnant groups, although there were differences in age at diagnosis (25 vs. 16) and current age (41 vs. 35). There was no significant difference in the rate of renal complications (57% vs. 67%, P = 0.62) or pneumothorax (40% vs. 38%, P = 1.00) for the pregnant and never-pregnant groups, respectively. Pregnancy loss in women with TSC did not differ from population risks.


CONCLUSIONS
Pregnancy does not increase the risk of developing renal or pulmonary complications in women with TSC.
Mitchell
Anna L
AL
Department of Internal Medicine, University of Washington, Seattle, Washington 98105, USA.
Parisi
Melissa A
MA
Sybert
Virginia P
VP
D000328:Adult; D018207:Angiomyolipoma / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D018192:Lymphangioleiomyomatosis / Q000000981:diagnostic imaging / Q000209:etiology; D011030:Pneumothorax / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D011256:Pregnancy Outcome; D011859:Radiography; D012306:Risk; D014402:Tuberous Sclerosis / Q000150:complications*; D014481:United States / Q000453:epidemiology