title: Molecular epidemiology of macrolide resistance in neonatal bloodstream isolates of group B streptococci.
abstract: Pulsed-field gel electrophoresis (PFGE) was performed on 122 neonatal bloodstream isolates of group B streptococci (GBS) to further examine the relationship between macrolide resistance and serotype V GBS (GBS-V). Over one-third (35%) of macrolide-resistant GBS belonged to a single PFGE subtype of GBS-V, which was also the most common GBS-V subtype noted in previous Centers for Disease Control and Prevention surveillance studies. Erm methylase (ermA and ermB) was the most common resistance mechanism detected, present in 12 of 20 macrolide-resistant GBS.
authors.affiliation: Department of Internal Medicine, University of Iowa Colleges of Medicine and Public Health, Iowa City, Iowa 52242, USA. daniel-diekema@uiowa.edu
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Diekema
authors.forename: Janet I
authors.initials: JI
authors.lastname: Andrews
authors.forename: Holly
authors.initials: H
authors.lastname: Huynh
authors.forename: Paul R
authors.initials: PR
authors.lastname: Rhomberg
authors.forename: Stella R
authors.initials: SR
authors.lastname: Doktor
authors.forename: Jill
authors.initials: J
authors.lastname: Beyer
authors.forename: Virginia D
authors.initials: VD
authors.lastname: Shortridge
authors.forename: Robert K
authors.initials: RK
authors.lastname: Flamm
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
authors.forename: Michael A
authors.initials: MA
authors.lastname: Pfaller
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics; D001769:Blood / Q000382:microbiology*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D007231:Infant, Newborn; D018942:Macrolides; D008780:Methyltransferases / Q000235:genetics; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D012703:Serotyping; D013290:Streptococcal Infections / Q000382:microbiology; D013292:Streptococcus agalactiae / Q000145:classification / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D018942:Macrolides; D008780:Methyltransferases