title: Adaptor proteins in lymphocyte activation.
abstract: Adaptor proteins are unique, as they contain modular domains and lack intrinsic enzymatic activity. These proteins are scaffolds for the organization of macromolecular complexes and they recruit other proteins for correct localization during molecular signal transduction. Numerous recent advances have been made through the elucidation of new adaptor proteins and the recognition of novel functions for previously identified molecules. In addition, the roles of adaptors in both the positive and negative regulation of lymphocyte activation have been further clarified.
authors.affiliation: Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: Erin
authors.initials: E
authors.lastname: Janssen
authors.forename: Weiguo
authors.initials: W
authors.lastname: Zhang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism; D000818:Animals; D050882:CREB-Binding Protein; D002352:Carrier Proteins / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008565:Membrane Proteins / Q000378:metabolism; D018448:Models, Immunological; D009687:Nuclear Proteins / Q000378:metabolism; D050722:Oncogene Protein v-cbl; D010750:Phosphoproteins / Q000378:metabolism; D011506:Proteins; D015682:Retroviridae Proteins, Oncogenic / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport; C113939:B cell linker protein; D002352:Carrier Proteins; C419196:LAT2 protein, human; C488163:LAT2 protein, mouse; C469997:LAX1 protein, human; D008565:Membrane Proteins; D009687:Nuclear Proteins; D050722:Oncogene Protein v-cbl; C498710:PAG1 protein, human; D010750:Phosphoproteins; D011506:Proteins; D015682:Retroviridae Proteins, Oncogenic; C109742:SLMAP protein, human; C092947:SLP-76 signal Transducing adaptor proteins; D015534:Trans-Activators; D050882:CREB-Binding Protein; C494363:CREBBP protein, human