NRAMP1 polymorphisms, susceptibility and clinical features of tuberculosis.
OBJECTIVE
To study whether NRAMP1 gene polymorphisms in a Japanese population affect susceptibility to tuberculosis and clinical features of tuberculosis.


METHODS
Polymerase chain reaction and restriction fragment-length polymorphism analyses were used to type NRAMP1 polymorphisms in 95 patients with pulmonary tuberculosis and 90 controls. Clinical features of patients also were investigated.


RESULTS
No association was seen between susceptibility to tuberculosis and NRAMP1 polymorphisms. Patients with the D543N A allele were significantly more likely than others to develop a cavitary lesion; by logistic regression analysis with adjustment for gender, age, and presence of diabetes, the odds ratio in patients with an A allele was 5.16 (95% confidence interval, 1.30-20.45).


CONCLUSIONS
Genetic variation in the human NRAMP1 gene may be associated with cavitation in patients with tuberculosis.
Abe
T
T
Division of Respiratory Diseases, Chubu National Hospital, Obu, Aichi, Japan.
Iinuma
Y
Y
Ando
M
M
Yokoyama
T
T
Yamamoto
T
T
Nakashima
K
K
Takagi
N
N
Baba
H
H
Hasegawa
Y
Y
Shimokata
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D027682:Cation Transport Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007564:Japan; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000235:genetics*; D000099173:Natural Resistance-associated Macrophage Protein 1
D027682:Cation Transport Proteins; D000099173:Natural Resistance-associated Macrophage Protein 1