title: Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia.
abstract: Benzodiazepine (diazepam), triazolobenzodiazepines (brotizolam, triazolam) and platelet activating factor (PAF) antagonist (BN 52021) are administered to mice before acquisition and retrieval trials conducted using Morris water maze. Benzodiazepine has produced only anterograde amnesia and it has not produced retrograde amnesia. Triazolobenzodiazepines have produced both anterograde and retrograde amnesia. PAF antagonist (BN 52021) has only produced retrograde amnesia and it has not produced anterograde amnesia. The anterograde amnesia produced by benzodiazepine and triazolobenzodiazepines, has been prevented by benzodiazepine receptor antagonist (flumazenil). It suggests that benzodiazepine- and triazolobenzodiazepines-induced anterograde amnesia may be mediated through benzodiazepine receptors. On the other hand, retrograde amnesia produced by PAF antagonist (BN 52021) and triazolobenzodiazepines has been attenuated by PAF and PAF acetyl hydrolase inhibitors such as cigarette smoke extract (CSE) and phenylmethanesulfonylflouride. It suggests that triazolobenzodiazepine-induced retrograde amnesia may be mediated through blockade of PAF receptors.
authors.affiliation: Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India.
authors.forename: Manish Kumar
authors.initials: MK
authors.lastname: Saraf
authors.forename: Kamal
authors.initials: K
authors.lastname: Kishore
authors.forename: Koshi M
authors.initials: KM
authors.lastname: Thomas
authors.forename: Ajay
authors.initials: A
authors.lastname: Sharma
authors.forename: Manjeet
authors.initials: M
authors.lastname: Singh
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D020324:Amnesia, Anterograde / Q000139:chemically induced / Q000503:physiopathology*; D000648:Amnesia, Retrograde / Q000139:chemically induced / Q000503:physiopathology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001381:Azepines; D003975:Diazepam; D004224:Diterpenes; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D005260:Female; D005442:Flumazenil / Q000494:pharmacology; D046934:Ginkgolides; D007783:Lactones / Q000494:pharmacology; D007858:Learning / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D010741:Phospholipases A / Q000187:drug effects; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D010980:Platelet Membrane Glycoproteins / Q000187:drug effects / Q000502:physiology*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology; D012153:Retention, Psychology / Q000187:drug effects / Q000502:physiology*; D014229:Triazolam
chemical_list: D014151:Anti-Anxiety Agents; D001381:Azepines; D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D011963:Receptors, GABA-A; C039351:platelet activating factor receptor; D014229:Triazolam; D005442:Flumazenil; C020960:brotizolam; C045856:ginkgolide B; D010741:Phospholipases A; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D003975:Diazepam