title: Inhibition of pheromone biosynthesis in Helicoverpa armigera by pheromonostatic peptides.
abstract: Male insect accessory glands contain factors that are transferred during mating to the female, some inducing post-mating behavior, including the cessation of pheromone production, non-receptivity and the initiation of oviposition. One such factor is the Drosophila melanogaster sex-peptide (DrmSP). A pheromone suppression peptide, termed HezPSP, was identified in the moth Helicoverpa zea, isolated by HPLC and the active peak sequenced, but the activity of the synthesized peptide has not been reported to date. HezPSP bears no sequence homology to DrmSP. However, both peptides contain a disulfide bridge separated by an equal number, but dissimilar, amino acids. We herein report on the pheromonostatic activity of HezPSP partial peptides in the moth Helicoverpa armigera.
authors.affiliation: Department of Entomology, The Hebrew University, P.O. Box 12, Rehovot, 76100, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Eliyahu
authors.forename: V
authors.initials: V
authors.lastname: Nagalakshmi
authors.forename: S W
authors.initials: SW
authors.lastname: Applebaum
authors.forename: E
authors.initials: E
authors.lastname: Kubli
authors.forename: Y
authors.initials: Y
authors.lastname: Choffat
authors.forename: A
authors.initials: A
authors.lastname: Rafaeli
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003307:Copulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D019476:Insect Proteins / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008969:Molecular Sequence Data; D009036:Moths / Q000187:drug effects* / Q000502:physiology*; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*; D016415:Sequence Alignment; D012724:Sex Attractants / Q000037:antagonists & inhibitors* / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D012726:Sexual Behavior, Animal / Q000187:drug effects*
chemical_list: D019476:Insect Proteins; D010446:Peptide Fragments; D012724:Sex Attractants