title: Nonconvulsive status epilepticus due to a de novo contralateral focus during tiagabine adjunctive therapy.
abstract: We describe a 30-year-old woman with an infantile-onset epilepsy due to a left temporal gliotic area who developed a nonconvulsive status epilepticus (NCSE) during tiagabine (TGB) adjunctive therapy. The ictal EEG recording showed a de novo right temporal focus not previously evident. After the i.v. administration of 4 mg lorazepam, the NCSE episode rapidly resolved and her usual left temporal EEG abnormalities reappeared. To our knowledge this is the first case of paradoxical seizure exacerbation associated with TGB therapy in which the clinical and EEG features are congruous with a new contralateral focus.
authors.affiliation: Neurologic Unit-Maria Vittoria Hospital, Torino, Italy. imperid@inwind.it
authors.forename: Daniele
authors.initials: D
authors.lastname: Imperiale
authors.forename: Piero
authors.initials: P
authors.lastname: Pignatta
authors.forename: Paolo
authors.initials: P
authors.lastname: Cerrato
authors.forename: Elisa
authors.initials: E
authors.lastname: Montalenti
authors.forename: Carlo
authors.initials: C
authors.lastname: Ravetti
authors.forename: Paolo
authors.initials: P
authors.lastname: Benna
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D004292:Dominance, Cerebral / Q000187:drug effects*; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D017029:Epilepsy, Complex Partial / Q000188:drug therapy*; D005260:Female; D005911:Gliosis / Q000150:complications; D006801:Humans; D009557:Nipecotic Acids / Q000008:administration & dosage / Q000009:adverse effects*; D010296:Parietal Lobe / Q000187:drug effects; D013226:Status Epilepticus / Q000139:chemically induced* / Q000175:diagnosis; D013702:Temporal Lobe / Q000187:drug effects; D000078308:Tiagabine
chemical_list: D000927:Anticonvulsants; D009557:Nipecotic Acids; D000078308:Tiagabine