title: Regulation of cell function by Rho GTPases.
abstract: Small GTPases of the Rho family regulate a wide variety of cell functions. In this review, we briefly describe the biological activities of Rho GTPases. Using the Rac-regulated NADPH oxidase as an example, we discuss possible regulatory points that might be exploited for drug development. Finally, we explore strategies for specific targeting of Rho GTPase-regulated signaling pathways.
authors.affiliation: The Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA.
authors.forename: C
authors.initials: C
authors.lastname: DerMardirossian
authors.forename: G M
authors.initials: GM
authors.lastname: Bokoch