title: Regulation of apoptosis in African swine fever virus-infected macrophages.
abstract: A number of viruses have evolved antiapoptotic mechanisms to promote infected-cell survival, either to ensure efficient productive viral replication or to promote long-term survival of virus-infected cells. Recent studies identified critical African swine fever virus genes involved in the complex regulation of ASFV-host interactions. Here we review the present knowledge of the recently identified ASFV genes with special attention to those which affect viral virulence, host range, and pathogenesis by regulating viral-induced apoptotic mechanisms.
authors.affiliation: Plum Island Animal Disease Center, USDA, ARS, P.O.Box 848, Greenport, NY 11944, USA. lzsak@piadc.ars.usda.gov
authors.forename: Laszlo
authors.initials: L
authors.lastname: Zsak
authors.forename: John G
authors.initials: JG
authors.lastname: Neilan
mesh_terms: D000357:African Swine Fever; D000358:African Swine Fever Virus / Q000235:genetics* / Q000472:pathogenicity; D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D005814:Genes, Viral / Q000235:genetics / Q000502:physiology; D008264:Macrophages / Q000821:virology*; D015678:Viral Structural Proteins / Q000235:genetics; D014774:Virulence / Q000235:genetics
chemical_list: D015678:Viral Structural Proteins