title: Cognitive development of lead exposed children from ages 6 to 15 years: an application of growth curve analysis.
abstract: The effect of lead exposure on cognitive growth patterns was assessed in a longitudinal study of 196 children. Performances on tests of verbal comprehension and perceptual organization (Vocabulary & Block Design, Wechsler Intelligence Scales for Children) were measured at ages 6.5, 11 and 15 years. Growth curve analyses revealed that the quadratic model best described the relationship between test scores and age. Children with higher lead levels, as measured at age 15 years, demonstrated lower verbal comprehension scores over time and greater decline in their rate of Vocabulary development at age 15 years, as compared to children with lower lead levels. Lead exposure was not significantly associated with growth in perceptual organization test scores. Socioeconomic status and maternal intelligence were statistically significantly associated with growth patterns for both test scores, independent of the effects of lead. The findings suggest that lead negatively impacts the developmental progression of specific cognitive skills from childhood through adolescence.
authors.affiliation: Children's Hospital Medical Center, Cincinnati, OH, USA. jcoscia@mfbrc.com
authors.forename: Juliet M
authors.initials: JM
authors.lastname: Coscia
authors.forename: M Douglas
authors.initials: MD
authors.lastname: Ris
authors.forename: Paul A
authors.initials: PA
authors.lastname: Succop
authors.forename: Kim N
authors.initials: KN
authors.lastname: Dietrich
mesh_terms: D000293:Adolescent; D002648:Child; D002657:Child Development / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000139:chemically induced / Q000523:psychology; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006128:Growth / Q000187:drug effects*; D006801:Humans; D007360:Intelligence / Q000187:drug effects; D007854:Lead / Q000009:adverse effects* / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects; D012044:Regression Analysis; D014705:Verbal Behavior / Q000187:drug effects
chemical_list: D007854:Lead