2-octyl cyanoacrylate adhesive for conjunctival wound closure in rabbits.
OBJECTIVE
To evaluate the efficacy and histology of 2-octyl cyanoacrylate in conjunctival wound closure in rabbits.


METHODS
Ten eyes of 10 New Zealand white rabbits were used. Eight rabbits had conjunctival wounds that were repaired with 2-octyl cyanoacrylate. Two rabbits were killed at 1 week and two rabbits were killed at 2 weeks and their conjunctivae were examined histologically. From two additional rabbits, conjunctival strips were obtained that underwent tensile strength testing.


RESULTS
All conjunctival wounds closed well with 2-octyl cyanoacrylate. Histology revealed minimal inflammation of the wounds. The tensile strength of conjunctival strips glued together was 25.5 g (standard deviation, 1.9 g).


CONCLUSIONS
2-Octyl cyanoacrylate may be a possible tissue adhesive for conjunctival wound closure.
Kim
Yuri M
YM
Department of Ophthalmology & Visual Sciences, University of Illinois at Chicago, USA.
Gupta
Balaji K
BK
D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D003228:Conjunctiva / Q000293:injuries*; D003487:Cyanoacrylates / Q000627:therapeutic use; D005131:Eye Injuries / Q000188:drug therapy*; D023421:Models, Animal; D011817:Rabbits; D013529:Surgical Wound Dehiscence / Q000517:prevention & control; D013718:Tensile Strength / Q000502:physiology; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
D001672:Biocompatible Materials; D003487:Cyanoacrylates; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate