title: Quantification of mitral valve regurgitation by left ventricular volume and flow measurements using electron beam computed tomography: comparison with magnetic resonance imaging.
abstract: OBJECTIVE
  This study was designed to evaluate electron beam computed tomography (CT) for quantifying mitral regurgitation in comparison with magnetic resonance (MR) imaging as a reference method.
  
  
  METHODS
  Forty-three patients, among them 33 with known mitral regurgitation, underwent electron beam CT and MR imaging. Total left ventricular stroke volume (TSV), antegrade stroke volume (ASV), and mitral regurgitation volume (MRV) and fraction (MRF) were determined and compared between the two modalities. Additionally electron beam CT measurements were compared with the corresponding echocardiographic findings.
  
  
  RESULTS
  Significant differences between electron beam CT and MR imaging were found for measurements of TSV and MSV but not for ASV and MRF. There was a close linear correlation between both modalities for all parameters. Furthermore, there was good agreement between electron beam CT and echocardiography, although electron beam CT shows a tendency to overestimate mitral regurgitation slightly.
  
  
  CONCLUSIONS
  The results indicate that electron beam CT offers an additional procedure for quantifying mitral regurgitation and that it may be used as an alternative to MR imaging.
authors.affiliation: Department of Radiology, Charité Medical School, Hamboldt Universität su Berlin Schumannstrasse, Berlin, Germany. Lembcke@gmx.de
authors.forename: Alexander
authors.initials: A
authors.lastname: Lembcke
authors.forename: Till H
authors.initials: TH
authors.lastname: Wiese
authors.forename: Christian N H
authors.initials: CN
authors.lastname: Enzweiler
authors.forename: Dietmar E
authors.initials: DE
authors.lastname: Kivelitz
authors.forename: Simon
authors.initials: S
authors.lastname: Dushe
authors.forename: Pascal M
authors.initials: PM
authors.lastname: Dohmen
authors.forename: Adrian C
authors.initials: AC
authors.lastname: Borges
authors.forename: Patrik
authors.initials: P
authors.lastname: Rogalla
authors.forename: Bernd
authors.initials: B
authors.lastname: Hamm
mesh_terms: D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000000981:diagnostic imaging*; D013318:Stroke Volume / Q000502:physiology; D014057:Tomography, X-Ray Computed; D016277:Ventricular Function, Left / Q000502:physiology*