Effect of ulinastatin on microcirculation during excessive hemorrhage using fluid therapy.
Microcirculation kinetics during excessive hemorrhage and fluid therapy under anesthesia, with or without treatment with ulinastatin (urinary trypsin inhibitor), was studied by using the rabbit ear chamber. Sixteen rabbits were divided into 2 groups: 8 rabbits without ulinastatin treatment (group C) and 8 rabbits treated with ulinastatin (group U). The vascular diameter, blood-flow velocity, blood-flow rate and urinary output were maintained well in the ulinastatin group as compared to those in the control group. It is concluded that ulinastatin is effective in maintaining microcirculation during excessive hemorrhage and fluid therapy at the same volume.
Takada
Katsumi
K
Department of Anesthesiology, School of Medicine, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
Komori
Makiko
M
Notoya
Atsuko
A
Tomizawa
Yasuko
Y
Ozaki
Makoto
M
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D004431:Ear, External / Q000098:blood supply*; D005440:Fluid Therapy; D006023:Glycoproteins / Q000494:pharmacology*; D006470:Hemorrhage / Q000503:physiopathology / Q000628:therapy*; D008833:Microcirculation / Q000187:drug effects; D010940:Plant Proteins / Q000494:pharmacology*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D014361:Trypsin Inhibitors; D014554:Urination / Q000187:drug effects; D000516:alpha-Amylases / Q000037:antagonists & inhibitors
D006023:Glycoproteins; D010940:Plant Proteins; D014361:Trypsin Inhibitors; D000516:alpha-Amylases; C028665:urinastatin