title: Chaperones and folding of MHC class I molecules in the endoplasmic reticulum.
abstract: In this review we discuss the influence of chaperones on the general phenomena of folding as well as on the specific folding of an individual protein, MHC class I. MHC class I maturation is a highly sophisticated process in which the folding machinery of the endoplasmic reticulum (ER) is heavily involved. Understanding the MHC class I maturation per se is important since peptides loaded onto MHC class I molecules are the base for antigen presentation generating immune responses against virus, intracellular bacteria as well as tumours. This review discusses the early stages of MHC class I maturation regarding BiP and calnexin association, and differences in MHC class I heavy chain (HC) interaction with calnexin and calreticulin are highlighted. Late stage MHC class I maturation with focus on the dedicated chaperone tapasin is also discussed.
authors.affiliation: The Institution of Tumour Immunology, Lund University, BMC I12, S-223 62, Lund, Sweden. kajsa.paulsson@wblab.lu.se
authors.forename: Kajsa
authors.initials: K
authors.lastname: Paulsson
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D017920:Antiporters / Q000378:metabolism; D037281:Calnexin / Q000378:metabolism; D037282:Calreticulin / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000276:immunology / Q000378:metabolism*; D015395:Histocompatibility Antigens Class I / Q000737:chemistry*; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D026901:Membrane Transport Proteins; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism*; D018995:Myosin Heavy Chains / Q000378:metabolism; D017510:Protein Folding
chemical_list: D017920:Antiporters; D037282:Calreticulin; D015395:Histocompatibility Antigens Class I; D007136:Immunoglobulins; D026901:Membrane Transport Proteins; D018832:Molecular Chaperones; C107762:tapasin; D037281:Calnexin; D018995:Myosin Heavy Chains