title: Phenobarbital modifies antitumor effect of cyclophosphamide depending on the type of tumor cell death caused by it.
abstract: Antitumor effect of cyclophosphamide on LS and P388 tumors is realized via apoptosis and on HA-1 and Krebs-2 tumors resistant to apoptosis via necrosis of tumor cells. Phenobarbital induction of cyclophosphamide-metabolizing enzymes decreases and cimetidine inhibition potentiates the effect of cyclophosphamide on LS and P388 cells and does not modulate the effect on HA-1 and Krebs-2 cells. Presumably, apoptosis and necrosis of tumor cell are induced by different cyclophosphamide metabolites.
authors.affiliation: Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk.
authors.forename: V I
authors.initials: VI
authors.lastname: Kaledin
authors.forename: V P
authors.initials: VP
authors.lastname: Nikolin
authors.forename: T Yu
authors.initials: TY
authors.lastname: Baimak
authors.forename: M R
authors.initials: MR
authors.lastname: Galyamova
authors.forename: N A
authors.initials: NA
authors.lastname: Popova
authors.forename: E M
authors.initials: EM
authors.lastname: Andreeva
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism; D018906:Antineoplastic Agents, Alkylating / Q000378:metabolism* / Q000627:therapeutic use; D017209:Apoptosis / Q000502:physiology*; D045744:Cell Line, Tumor; D002927:Cimetidine / Q000378:metabolism; D003520:Cyclophosphamide / Q000378:metabolism* / Q000627:therapeutic use; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000378:metabolism; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy; D010634:Phenobarbital / Q000378:metabolism*
chemical_list: D000927:Anticonvulsants; D018906:Antineoplastic Agents, Alkylating; D004791:Enzyme Inhibitors; D002927:Cimetidine; D003520:Cyclophosphamide; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital