title: Expression of cytokine genes in adhesions on uterine tubes.
abstract: We studied expression of genes of interleukins, interferon-gamma, tumor necrosis factor-alpha, and transforming growth factor-beta(2) in adhesions on uterine tubes. In tubal adhesions the intensity of production of mRNA for proinflammatory cytokines, antiinflammatory cytokine interleukin-10, and regulator of cell proliferation surpassed that in normal tissues by 2.5-7.4, 2.2, and 50.2 times, respectively. Correlations were found between production of mRNA for tumor necrosis factor-alpha and transforming growth factor-beta(2), interleukin-12, and interferon-gamma and interleukin-12 and transforming growth factor-beta(2). Our results suggest that expression of these genes during adhesion formation is regulated by the feedback mechanism.
authors.affiliation: Research Center for Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow.
authors.forename: A V
authors.initials: AV
authors.lastname: Zhdanov
authors.forename: M P
authors.initials: MP
authors.lastname: Davydova
authors.forename: T G
authors.initials: TG
authors.lastname: Gabuniya
authors.forename: L V
authors.initials: LV
authors.lastname: Van'ko
authors.forename: T A
authors.initials: TA
authors.lastname: Nazarenko
authors.forename: V I
authors.initials: VI
authors.lastname: Kulakov
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
mesh_terms: D016207:Cytokines / Q000235:genetics*; D005184:Fallopian Tube Diseases / Q000209:etiology / Q000235:genetics* / Q000276:immunology*; D005246:Feedback; D005260:Female; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007371:Interferon-gamma / Q000235:genetics; D007378:Interleukins / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D000267:Tissue Adhesions / Q000209:etiology / Q000235:genetics / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D007378:Interleukins; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma