title: [An experimental study on the prevention and treatment of postburn intestinal injury and bacterial translocation by Sijunzi decoction in scalded rats].
abstract: OBJECTIVE
  To explore the effects of traditional Chinese herbal medicine Sijunzi decoction on amelioration of postburn intestinal injury in scalded rats.
  
  
  METHODS
  One hundred and eighty Wistar rats were randomly divided into 3 groups, i.e. scald and treatment (T), scald control (S) and normal control (C) groups. The rats in T group were gavaged with the decoction consisting of tangshen, tuckahoe, large head atractylodes rhizome, glycyrrhizic and rhubarb in a dose of 2 ml twice daily, while the rats in C group were just gavaged with the same amount of distilled water. The rats were sacrificed according to the scheduled postburn observation timepoints. The contents of TNF, NO, MDA and ATPase activity in rat plasma and the intestinal mucosa and the S-IgA content in the intestinal mucus were determined respectively. The changes in histopathology of intestinal mucosa were observed. The samples from internal organ tissue and blood were obtained for bacterial culture.
  
  
  RESULTS
  The contents of TNF, NO and MDA in the intestinal mucosa tissue and the rat plasma in scalded rats were lowered significantly by Sijunzi decoction. Furthermore, S-IgA secretion from intestinal mucous cells was maintained by Sijunzi decoction. T cell count was recovered and intestinal mucous barrier injury were lessened, and the bacterial positive rate in the internal organs was decreased.
  
  
  CONCLUSIONS
  Traditional Chinese herbal medicine Sijunzi decoction might be helpful in alleviation of postburn intestinal injury and in the prevention of intestinal bacterial translocation.
authors.affiliation: Department of Burns and plastic Surgery. Hospital, Luzhou Medical College, Luzhou, 646000 Sichuan Provine P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Guo
authors.forename: Nan-Ding
authors.initials: ND
authors.lastname: Dong
authors.forename: Ai-Bing
authors.initials: AB
authors.lastname: Xiong
authors.forename: Zheng-Yu
authors.initials: ZY
authors.lastname: Liu
authors.forename: Cheng-Rong
authors.initials: CR
authors.lastname: Liu
authors.forename: Xiao-Chuan
authors.initials: XC
authors.lastname: He
mesh_terms: D000818:Animals; D018988:Bacterial Translocation / Q000187:drug effects*; D002056:Burns / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology*; D007422:Intestines / Q000382:microbiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004365:Drugs, Chinese Herbal