title: mRNA cap-1 methyltransferase in the SARS genome.
abstract: The 3D jury system has predicted the methyltransferase fold for the nsp13 protein of the SARS coronavirus. Based on the conservation of a characteristic tetrad of residues, the mRNA cap-1 methyltransferase function has been assigned to this protein, which has potential implications for antiviral therapy.
authors.forename: Marcin
authors.initials: M
authors.lastname: von Grotthuss
authors.forename: Lucjan S
authors.initials: LS
authors.lastname: Wyrwicz
authors.forename: Leszek
authors.initials: L
authors.lastname: Rychlewski
mesh_terms: D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D016679:Genome, Viral; D008780:Methyltransferases / Q000235:genetics* / Q000378:metabolism; D008958:Models, Molecular; D017434:Protein Structure, Tertiary / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism*; D045473:Severe acute respiratory syndrome-related coronavirus / Q000201:enzymology* / Q000235:genetics*; D045169:Severe Acute Respiratory Syndrome / Q000821:virology*; D048008:TNF Receptor-Associated Factor 3; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; D014764:Viral Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D012333:RNA, Messenger; D048008:TNF Receptor-Associated Factor 3; C090656:TRAF3 protein, human; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; D014764:Viral Proteins; D008780:Methyltransferases