title: Temporal lobectomy in congenital porencephaly associated with hippocampal sclerosis.
abstract: BACKGROUND
  Clinical and neuroimaging features of patients with epilepsy and coexisting extratemporal porencephaly and hippocampal sclerosis have been previously described.
  
  
  OBJECTIVE
  To present the clinical characteristics and surgical outcome of 6 patients with intractable epilepsy and coexisting extratemporal porencephaly and hippocampal sclerosis.
  
  
  METHODS
  Twenty-four patients with porencephaly and epilepsy were studied. Of these, 6 had an epileptogenic focus in the temporal region. All patients underwent video electroencephalogram monitoring, magnetic resonance imaging studies, and neuropsychological evaluation. Of the subset of patients with temporal lobe epilepsy, 1 patient underwent intracranial electroencephalogram monitoring. Temporal lobe resection was performed in 5 patients. Outcomes were evaluated using the Engel classification.
  
  
  RESULTS
  Freedom from seizures was achieved in all patients. Pathologic analysis of the resected tissue confirmed the presurgical diagnosis of mesial temporal sclerosis.
  
  
  CONCLUSIONS
  Patients with extratemporal porencephaly and intractable seizures should be evaluated early and be considered for temporal lobectomy if clinical, magnetic resonance imaging, and electroencephalogram findings support the diagnosis of temporal lobe onset seizures.
authors.affiliation: Department of Neurology, Epilepsy Center, University of Alabama at Birmingham, 35294, USA. rkuzniecky@uabmc.edu
authors.forename: Jorge G
authors.initials: JG
authors.lastname: Burneo
authors.forename: Edward
authors.initials: E
authors.lastname: Faught
authors.forename: Robert C
authors.initials: RC
authors.lastname: Knowlton
authors.forename: Roy C
authors.initials: RC
authors.lastname: Martin
authors.forename: Martina
authors.initials: M
authors.lastname: Bebin
authors.forename: Richard
authors.initials: R
authors.lastname: Morawetz
authors.forename: Ruben
authors.initials: R
authors.lastname: Kuzniecky
mesh_terms: D000293:Adolescent; D000328:Adult; D001927:Brain Diseases / Q000151:congenital / Q000601:surgery*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000601:surgery*; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures; D012598:Sclerosis; D013702:Temporal Lobe / Q000601:surgery*; D016896:Treatment Outcome