title: Choroid plexus carcinoma presented with spinal dysfunction caused by a drop metastasis: a case report.
abstract: A 2-year-old girl demonstrating gait disturbance and dysuria was evaluated and showed two large remote tumors at the left lateral ventricle and lower spinal canal. Pathological analysis demonstrated both of the tumors to be choroid plexus carcinoma (CPC) with high MIB-1 labeling index. The enhanced mitotic propensity would have contributed to an early stage of drop metastasis from the primary site to the sacral sac and following accelerated formation of a longitudinal tumor, which had grown in the subarachnoid space conforming to the spinal canal and finally caused the presenting symptoms of spinal dysfunction. This report shows that CPC can develop exophytically in the subarachnoid space as well as in the ventricle simultaneously before appearance of clinical symptoms and confirms the importance of extensive neuroimaging in its evaluation.
authors.affiliation: Department of Pediatrics, Akita University School of Medicine, Akita, Japan. sawaishi@ped.med.akita-u.ac.jp
authors.forename: Yukio
authors.initials: Y
authors.lastname: Sawaishi
authors.forename: Tamami
authors.initials: T
authors.lastname: Yano
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Ito
authors.forename: Kazuo
authors.initials: K
authors.lastname: Mizoi
authors.forename: Aya
authors.initials: A
authors.lastname: Hirayama
authors.forename: Iwao
authors.initials: I
authors.lastname: Takaku
authors.forename: Goro
authors.initials: G
authors.lastname: Takada
mesh_terms: D001932:Brain Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002675:Child, Preschool; D016545:Choroid Plexus Neoplasms / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008279:Magnetic Resonance Imaging; D013120:Spinal Cord Neoplasms / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D013122:Spinal Diseases / Q000209:etiology
chemical_list: D019394:Ki-67 Antigen