Expression of cytokine genes in adhesions on uterine tubes.
We studied expression of genes of interleukins, interferon-gamma, tumor necrosis factor-alpha, and transforming growth factor-beta(2) in adhesions on uterine tubes. In tubal adhesions the intensity of production of mRNA for proinflammatory cytokines, antiinflammatory cytokine interleukin-10, and regulator of cell proliferation surpassed that in normal tissues by 2.5-7.4, 2.2, and 50.2 times, respectively. Correlations were found between production of mRNA for tumor necrosis factor-alpha and transforming growth factor-beta(2), interleukin-12, and interferon-gamma and interleukin-12 and transforming growth factor-beta(2). Our results suggest that expression of these genes during adhesion formation is regulated by the feedback mechanism.
Zhdanov
A V
AV
Research Center for Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow.
Davydova
M P
MP
Gabuniya
T G
TG
Van'ko
L V
LV
Nazarenko
T A
TA
Kulakov
V I
VI
Sukhikh
G T
GT
D016207:Cytokines / Q000235:genetics*; D005184:Fallopian Tube Diseases / Q000209:etiology / Q000235:genetics* / Q000276:immunology*; D005246:Feedback; D005260:Female; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007371:Interferon-gamma / Q000235:genetics; D007378:Interleukins / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D000267:Tissue Adhesions / Q000209:etiology / Q000235:genetics / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D016207:Cytokines; D018836:Inflammation Mediators; D007378:Interleukins; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma