title: Comparison of gastric histology among Swedish and Japanese patients with peptic ulcer and Helicobacter pylori infection.
abstract: BACKGROUND
  The natural course of Helicobacter pylori gastritis may vary between different ethnic groups. Gastric histopathology and the occurrence of H. pylori organisms in the stomach were investigated in healed duodenal (DU) and gastric (GU) ulcer patients recruited in Sweden (S) and Japan (J) in an identical trial.
  
  
  METHODS
  In 203 patients (JGU = 39, JDU = 55, SDU = 109), various morphological gastritis variables and H. pylori were assessed from biopsy specimens obtained using a specific sampling protocol and interpreted according to guidelines of the updated Sydney grading system.
  
  
  RESULTS
  The ratio of GU:DU was observed to be very different between the recruited Japanese (39:55) and Swedish (0:109) patients. A comparison of data from SDU and JDU showed that the prevalence of H. pylori infection and the antral predominant gastritis demonstrated by both SDU and JDU were essentially identical. A comparison of data from JDU and JGU demonstrated a greater prevalence of H. pylori infection in the antrum, but not corpus, of JDU compared to JGU patients. The prevalence of atrophy and intestinal metaplasia was higher in both the antrum and corpus of JGU compared to JDU in all patients.
  
  
  CONCLUSIONS
  The site specified biopsy methodology and standardized interpretation criteria utilized in this study clearly show that the histotopographic profile of Swedish and Japanese DU patients is essentially the same.
authors.affiliation: Dept. of Gastroenterology, Jichi Medical School, Yakushiji, Tochigi-ken, Japan. kimuken-go@sannet.ne.jp
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: P
authors.initials: P
authors.lastname: Sipponen
authors.forename: P
authors.initials: P
authors.lastname: Unge
authors.forename: P
authors.initials: P
authors.lastname: Ekström
authors.forename: K
authors.initials: K
authors.lastname: Satoh
authors.forename: M
authors.initials: M
authors.lastname: Hellblom
authors.forename: B
authors.initials: B
authors.lastname: Ohlin
authors.forename: A
authors.initials: A
authors.lastname: Stubberöd
authors.forename: K
authors.initials: K
authors.lastname: Kihira
authors.forename: T
authors.initials: T
authors.lastname: Yube
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshida
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis / Q000382:microbiology* / Q000473:pathology* / Q000503:physiopathology; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000382:microbiology* / Q000473:pathology; D013270:Stomach / Q000473:pathology*; D013548:Sweden