Lethal invasive cestodiasis in immunosuppressed patients.
Using both traditional methods and broad-range 18S ribosomal DNA (rDNA) polymerase chain reaction, we examined 2 cases of lethal cestodiasis, in which the disease agent had been poorly identified or misidentified. In one case, involving a patient with AIDS, we identified the human dwarf tapeworm, Hymenolepis nana, as a cause of aberrant metastatic larval disease. In the second case with similar pathologic abnormalities, involving a patient with Hodgkin disease, we identified a larval cestode with a previously uncharacterized 18S rDNA sequence. A prior report of this case nearly 30 years ago, based on tissue examination, had suggested that the parasite was a sparganum.
Olson
Peter D
PD
Parasitic Worms Division, Department of Zoology, Natural History Museum, London, United Kingdom. P.Olson@nhm.ac.uk
Yoder
Kristine
K
Fajardo L-G
Luis F
LF
Marty
Aileen M
AM
van de Pas
Simone
S
Olivier
Claudia
C
Relman
David A
DA
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology* / Q000469:parasitology; D000818:Animals; D002589:Cestoda / Q000235:genetics / Q000302:isolation & purification; D002590:Cestode Infections / Q000150:complications* / Q000276:immunology*; D004275:DNA, Ribosomal / Q000032:analysis; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000150:complications* / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D008297:Male; D009894:Opportunistic Infections / Q000150:complications / Q000276:immunology / Q000469:parasitology; D010802:Phylogeny; D012337:RNA, Ribosomal, 18S / Q000032:analysis
D004275:DNA, Ribosomal; D012337:RNA, Ribosomal, 18S