title: Spontaneous cerebellar dysplasias in BrlHan: WIST@Jcl rats.
abstract: Focal disturbed laminar architecture in cerebellar vermis was observed in 25 out of 100 (25%) males, and 25 out of 100 (25%) females of BrlHan: WIST@Jcl rats. The cortical molecular and granular layers were haphazardly distributed around the primary and/or secondary fissures. The stellate and basket cells positively stained with parvalbumin immunohistochemistry were observed exclusively in the separated molecular layer. Purkinje cells were found at the boundary between the molecular and the granular layers. Glial fibrillary acid protein (GFAP) immunohistochemistry revealed disarranged fibers of the Bergman glial cells. Based on the incidence of this spontaneous cerebellar lesion, it was presumed to be related to certain genetic factors of this rat strain.
authors.affiliation: Tanabe Seiyaku Co., Ltd., Safety Research Laboratory, 16-89 Kashima 3-Chome, Yodogawa-Ku, Osaka 532-0031, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kuwamura
authors.forename: Tamiko
authors.initials: T
authors.lastname: Adachi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Takatani
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yuasa
mesh_terms: D000818:Animals; D002526:Cerebellar Diseases / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005904:Glial Fibrillary Acidic Protein