title: Histological and macroscopic changes in the pelvic pouch: long-term follow up after restorative proctocolectomy for ulcerative colitis (UC).
abstract: OBJECTIVE
  Our aim was to evaluate macroscopic and histological (inflammatory) changes in ileal pouch mucosa after restorative proctocolectomy with J-pouch-ileoanal anastomosis for UC during long-term follow up.
  
  
  METHODS
  Thirty-six (56%) out of 64 consecutive patients operated at our Institute during 1985-90 underwent endoscopy of the reservoir in the years 1994 and 1998. Functional outcome and macroscopic changes were recorded and histological samples taken from the three levels of the pelvic pouch. Acute and chronic inflammation were graded in accordance with a well-established histopathologic scoring system.
  
  
  RESULTS
  The functional outcome was unchanged in 26 (72%), became worse in eight (22%) and better in two (6%) cases during follow up. The number of macroscopic changes increased during follow up and there was a tendency for them to become more common in the distal pouch. Microscopic acute and chronic inflammation decreased during follow up. There were more severe inflammatory changes in the distal pouch. Both acute and chronic inflammatory scores were higher through the reservoir in the cases of chronic pouchitis. Chronic pouchitis occurred more often in males.
  
  
  CONCLUSIONS
  Macroscopic and inflammatory changes in the pelvic pouch seem to have separate progress during long-term follow up. In chronic pouchitis both acute and chronic inflammation are pronounced and spread over the entire pelvic pouch mucosa.
authors.affiliation: Department of Surgery, Tampere University Hospital, Tampere, Finland. HTTP://www.juha.tiainen@pp1.inet.fi
authors.forename: J
authors.initials: J
authors.lastname: Tiainen
authors.forename: M
authors.initials: M
authors.lastname: Matikainen
authors.forename: P
authors.initials: P
authors.lastname: Aitola
authors.forename: K M
authors.initials: KM
authors.lastname: Hiltunen
authors.forename: J
authors.initials: J
authors.lastname: Mattila