Host genetic factors in the clinical course of HIV-1 infection: chemokines and chemokine receptors.
The outcome of HIV-1 infection is highly variable: not all individuals exposed to HIV-1 will become infected, and among individuals who do become infected, the time from seroconversion to AIDS diagnosis is highly variable. Some patients may develop AIDS within 3 years, whereas others may remain asymptomatic for over 15 years. The reasons for these differences are not fully understood, but are thought to reflect the complex interactions between virus and host. In recent years, an important role for host genetic factors in the pathogenesis of HIV-1 infection has increasingly been appreciated. Many novel genetic polymorphisms have been identified and analyzed for their role in HIV-1 transmission and disease progression. In this review, we will give an update of the current knowledge on the role of such polymorphisms in HIV-1 disease. As recent research in this field has focussed on polymorphisms in chemokine and chemokine receptor genes, this will be the main theme of our review.
van Rij
Ronald P
RP
Department of Clinical Viro-Immunology, CLB Sanquin and the Laboratory of Experimental and Clinical Immunology of the University of Amsterdam, Amsterdam, The Netherlands.
Schuitemaker
Hanneke
H