title: Frequency of cytochrome P450 2C9 allelic variants in the Chinese and French populations.
abstract: Cytochrome P450 2C9 (CYP2C9) is a polymorphic enzyme responsible for the metabolism of different drugs with low therapeutic index such as oral anticoagulants. CYP2C9*2 and CYP2C9*3 are two single nucleotide polymorphic allelic variants. The frequency of these alleles in different ethnic populations is extremely variable. In this study, we compared the frequencies of CYP2C9 allelic variants among 394 Chinese living in Shanghai to 151 French Caucasians living in Paris. The allelic frequencies of CYP2C9 variants of the Chinese and the French subjects were 0.963, 0.001, 0.036 and 0.77, 0.15, 0.08 for CYP2C9*1, CYP2C9*2, CYP2C9*3, respectively. Chinese CYP2C9*3 allelic frequency was twice as lower as the French subjects, but three times higher than Korean (0.036 vs. 0.011). The CYP2C9*2 allele could be detected in only one Chinese subject, whereas it represented the major allelic variant in French Caucasians. The low frequency of the CYP2C9*2 and CYP2C9*3 allelic variants in Chinese subjects does not justify their detection in clinical practice, unlike French Caucasians.
authors.affiliation: Pharmacology Department, Saint Antoine University Hospital - University Pierre et Marie Curie - Assistance Publique-Hôpitaux de Paris, Paris, France.
authors.forename: Jue Quin
authors.initials: JQ
authors.lastname: Yang
authors.forename: Sandrine
authors.initials: S
authors.lastname: Morin
authors.forename: Céline
authors.initials: C
authors.lastname: Verstuyft
authors.forename: Li An
authors.initials: LA
authors.lastname: Fan
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chun Di
authors.initials: CD
authors.lastname: Xu
authors.forename: Véronique
authors.initials: V
authors.lastname: Barbu
authors.forename: C
authors.initials: C
authors.lastname: Funck-Brentano
authors.forename: Patrice
authors.initials: P
authors.lastname: Jaillon
authors.forename: Laurent
authors.initials: L
authors.lastname: Becquemont
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002648:Child; D002681:China; D065729:Cytochrome P-450 CYP2C9; D005260:Female; D005602:France; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics*
chemical_list: C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases