Mesenchymal stem cells and hematopoietic stem cell transplantation.
Techniques have recently beome available to isolate and grow mesenchymal progenitors and to manipulate their growth under defined in vitro culture conditions. As a result mesenchymal stem cells can be rapidly expanded to numbers that are required for clinical application. This has allowed the clinical testing of culture-expanded MSCs in the context of hematopoietic stem cell transplantation. In this paper we discuss the role of MSCs in hematopoietic engraftment after transplantation.
Fibbe
Willem E
WE
Laboratory of Experimental Hematology, Department of Hematology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands. W.E.Fibbe@LUMC.nl
Noort
Willy A
WA
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D064987:Cell- and Tissue-Based Therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods* / Q000639:trends; D006801:Humans; D008648:Mesoderm / Q000166:cytology* / Q000276:immunology; D013234:Stem Cells / Q000166:cytology*