[Development of a porcine experimental model of alcoholic intoxication].
Despite important epidemiologic suggestions that alcohol causes a variety of cardiovascular abnormalitíes, and particularly cardiac arrhythmias, the demonstration of this causal effect in animal models is still lacking. Previous open-chest models, heavily instrumented and using epicardial stimulation have failed to demonstrate such causal effect. We developed a porcine, closed-chest model with sedation, a rigorous control of venous alcohol concentration and endocardial electrical stimulation, in a multidisciplinary framework. In this model, we observed that the infusion of alcohol facilitated atrial tachyarrhythmias. This model is available to study a variety of alcohol effects "in vivo", in a controlled fashion.
Anadón Baselga
María José
MJ
D000293:Adolescent; D000368:Aged; D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000435:Alcoholic Intoxication / Q000097:blood / Q000503:physiopathology*; D000438:Alcohols / Q000097:blood / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001281:Atrial Fibrillation / Q000139:chemically induced; D001282:Atrial Flutter / Q000139:chemically induced; D002374:Catalase / Q000378:metabolism; D002648:Child; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D013552:Swine; D013610:Tachycardia / Q000139:chemically induced / Q000209:etiology
D000438:Alcohols; D003577:Cytochrome P-450 Enzyme System; D000429:Alcohol Oxidoreductases; C092153:microsomal ethanol-oxidizing system; D000426:Alcohol Dehydrogenase; D002374:Catalase