Ceramic drug delivery: a perspective.
Different ceramic substances are offered in the market as bone substitute materials. These include monophasic calcium phosphate ceramics of tricalciumphosphate (TCP) or hydroxyapatite (HA), biphasic calcium phosphate ceramics and multiphasic bio-glasses synthetic calcium phosphate cements. Ceramics with appropriate three-dimensional geometry are able to bind and concentrate bone morphogenetic proteins in circulation and may become osteoinductive (capable of osteogenesis) and can be effective carriers of bioactive peptide or bone cell seeds and are therefore potentially useful in tissue engineering and drug delivery. An attempt has been made to review various drug delivery applications of ceramics.
Paul
Willi
W
Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695012, India.
Sharma
Chandra P
CP
D001672:Biocompatible Materials / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage; D018786:Bone Substitutes / Q000737:chemistry; D002516:Ceramics / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D023822:Tissue Engineering
D001672:Biocompatible Materials; D001843:Bone Cements; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes