title: Effects of anti-allergic drugs on intestinal mastocytosis and worm expulsion of rats infected with Neodiplostomum seoulense.
abstract: The effects of anti-allergic drugs on intestinal mastocytosis and the expulsion of Neodiplostomum seoulense were observed in Sprague-Dawley rats, after oral infection with 500 metacercariae. The drugs used were hydroxyzine (a histamine receptor H1 blocker), cimetidine (a H2 blocker), cyclosporin-A (a helper T-cell suppressant), and prednisolone (a T- and B-cell suppressant). Infected, but untreated controls, and uninfected controls, were prepared. Worm recovery rate and intestinal mastocytosis were measured on weeks 1, 2, 3, 5, and 7 post-infection. Compared with the infected controls, worm expulsion was significantly (P < 0.05) delayed in hydroxyzine- and cimetidine-treated rats, despite mastocytosis being equally marked in the duodenum of all three groups. In the cyclosporin-A- and prednisolone-treated groups, mastocytosis was suppressed, but worm expulsion was only slightly delayed, without statistical significance. Our results suggest that binding of histamine to its receptors on intestinal smooth muscles is more important in terms of the expulsion of N. seoulense from rats than the levels of histamine alone, or mastocytosis.
authors.affiliation: Department of Parasitology and Tropical Medicine, College of Medicine and Institute of Endemic Diseases, Medical Research Center, Seoul National University, Seoul 110-799, Korea.
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Shin
authors.forename: Tae-Heung
authors.initials: TH
authors.lastname: Kim
authors.forename: Sung-Jong
authors.initials: SJ
authors.lastname: Hong
authors.forename: Jae-Hwan
authors.initials: JH
authors.lastname: Park
authors.forename: Sang-Mee
authors.initials: SM
authors.lastname: Guk
authors.forename: Jong-Yil
authors.initials: JY
authors.lastname: Chai
mesh_terms: D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D016572:Cyclosporine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006919:Hydroxyzine / Q000494:pharmacology / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy*; D008415:Mastocytosis / Q000188:drug therapy* / Q000469:parasitology; D011239:Prednisolone / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014200:Trematoda / Q000254:growth & development* / Q000378:metabolism; D014201:Trematode Infections / Q000188:drug therapy*
chemical_list: D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D007166:Immunosuppressive Agents; D006919:Hydroxyzine; D002927:Cimetidine; D016572:Cyclosporine; D011239:Prednisolone