title: Quantitative flow measurements for classification of ovarian tumors by transvaginal color Doppler sonography in postmenopausal patients.
abstract: Color Doppler and Duplex measurements were obtained in 83 (42 benign, 41 malignant) ovarian tumors in postmenopausal patients. An ATL UM9/HDI was used. The following flow criteria were analyzed: lowest resistance index (RI) and pulsatility index (PI), total number of arteries and number of central arteries and the maximum, mean and sum of systolic, end-diastolic and time-averaged maximum velocities of all intratumoral vessels. In 98% of malignant and in 85% of benign lesions, vessels were detected. All flow criteria showed highly significant differences between benign and malignant tumors (p < 0.0001). However, there was a considerable overlap between benign and malignant tumors (e.g. the median of the lowest RI was 0.62 (range 0.26-1.0) for benign and 0.40 (0.22-0.66) for malignant tumors; the median of the maximum systolic velocity was 17.5 cm/s (range 5.2-61.5 cm/s) for benign and 47.05 cm/s (14.6-105.0 cm/s) for malignant tumors). Differentiation of malignant tumors by the lowest RI and PI, number of arteries and maximum of systolic flow velocities gave a sensitivity of 77-85%, specificity of 77-83% and accuracy of 80-84%. Differentiation was superior by calculation of the maximum end-diastolic velocities and by the summation of the systolic, end-diastolic and time-averaged maximum flow velocities: sensitivity 90-9.5% specificity 83-86% and accuracy 87-91%. This study confirms that a single measurement is not sufficient for an accurate differentiation of ovarian lesions and, besides the measurement of minimum RI and PI, the measurements of flow velocities as Doppler criteria play an important role.
authors.affiliation: Department of Obstetrics and Gynecology, University of Freiburg, Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Prömpeler
authors.affiliation: Department of Obstetrics and Gynecology, University of Freiburg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Madjar
authors.affiliation: Institute for Medical Biometry and Informatics, University of Freiburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Sauerbrei
authors.affiliation: Department of Obstetrics and Gynecology, University of Freiburg, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Lattermann
authors.affiliation: Department of Obstetrics and Gynecology, University of Freiburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Pfleiderer