title: Transoral laser surgery for early glottic cancers.
abstract: OBJECTIVE
  To demonstrate the oncologic safety of transoral endoscopic laser surgery in early glottic cancers.
  
  
  METHODS
  The study included 107 patients with early glottic cancers. The disease was in situ in 21 (19.6%) and infiltrative in 86 (80.4%), of which 52 (48.6%) were stage T1a, 17 (15.9%) were T1b, 13 (12.1%) were T2, and 4 (3.7%) were TX lesions. One hundred three patients (96.3%) were treated primarily, whereas 4 patients (3.7%) were operated on after radiotherapy failure. Anatomically, 77 lesions (72.0%) involved the anterior or middle third of the vocal cord; 14 lesions (13.1%) involved a single cord and the anterior commissure; 4 "horseshoe" lesions (3.7%) involved both cords and the anterior commissure; 7 lesions (6.5%) involved the posterior third of the cord reaching the vocal process of the arytenoid; and 5 cases (4.7%) involved both cords separately.
  
  
  RESULTS
  There were 17 (15.9%) local recurrences (10 among patients with single cord lesions, 5 among patients with cord and anterior commissure lesions, and 2 among patients with lesions involving both cords), and 1 regional recurrence. One hundred one patients (94.4%) were alive and disease free at a median of 40.7 months. Three patients (2.8%) were alive with disease. One patient (0.9%) died of other causes. Two patients (1.9%) died of a second primary cancer. The overall larynx preservation rate was 92.5%. Recurrence-free survival was 86.6% at 2 years, 84.1% at 5 years, and 78.1% at 10 years.
  
  
  CONCLUSIONS
  Transoral laser surgery is an oncologically safe, function-preserving modality for treatment of early glottic cancers.
authors.affiliation: Head and Neck Services, Tata Memorial Hospital, Parel, Mumbai, India. npradhan@vsnl.com
authors.forename: Sultan A
authors.initials: SA
authors.lastname: Pradhan
authors.forename: Prathamesh S
authors.initials: PS
authors.lastname: Pai
authors.forename: Siddalingeshwar I
authors.initials: SI
authors.lastname: Neeli
authors.forename: Anil K
authors.initials: AK
authors.lastname: D'Cruz
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D053685:Laser Therapy / Q000379:methods*; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D019647:Oral Surgical Procedures / Q000379:methods*; D016896:Treatment Outcome