Pre-eclampsia and thrombophilia.
Pre-eclampsia is a major cause of perinatal and maternal morbidity and mortality worldwide. Although knowledge of the precise aetiology remains uncertain a number of risk factors have been described. Thrombophilias have been associated with pre-eclampsia in a number of studies and it is biologically plausible that they may contribute to the uteroplacental thrombosis that is frequently seen in pre-eclampsia. If this association is confirmed, there is the potential to investigate preventive treatments, including low-molecular-weight heparins, aspirin and folate.
Said
Joanne
J
Department of Perinatal Medicine, The Royal Women's Hospital, Melbourne, Australia. josaid@bigpond.net.au
Dekker
Gustaaf
G
D001777:Blood Coagulation; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000209:etiology* / Q000517:prevention & control; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications*