Piperacillin induced bone marrow suppression: a case report.
BACKGROUND
Piperacillin (and piperacillin/tazobactam) is a commonly prescribed antibiotic and is generally considered safe. We report a case of piperacillin induced bone marrow suppression.


METHODS
A 19-year-old boy was being treated with piperacillin followed by piperacillin/tazobactam for infected pancreatic pseudocyst. After 21 days of treatment, he developed neutropenia and thrombocytopenia. These reversed promptly after stopping piperacillin/tazobactam. The time course of events suggested that piperacillin was the cause of bone marrow suppression in this patient.


CONCLUSIONS
Bone marrow suppression is a serious adverse effect of piperacillin, which should be kept in mind while treating patients with this drug.
Kumar
Ashish
A
Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India. ashishk@sgpgi.ac.in
Choudhuri
Gourdas
G
Aggarwal
Rakesh
R
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010878:Piperacillin / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D010878:Piperacillin