title: [Fatal case during treatment of american tegumentary leishmaniasis with sodium stibogluconate bp 88  (shandong xinhua)].
abstract: The authors report the occurrence of a fatal case in patient with cutaneous leishmaniasis in the municipality of Caxias, MA. Male patient, 22 years old, road sweeper, presented with an ulcer in left leg, diagnosed as cutaneous leishmaniasis and treated with sodium stibogluconate BP88 (Sb+5) (Shandong Xinhua) at a dose of 10mg/Sb+5/kg/day/20 days. After dose three he presented arthralgia, myalgia, nausea and weakness. During the therapy there was an aggravation of the symptoms with abdominal pain and irradiation into the thorax. After dose seven he presented a picture of associated dyspnea and thoracic pain of mild intensity. At dose nine there was further worsening of the picture, nevertheless the therapy was continued up to dose 11, when the patient's state deteriorated to such an extent that he was hospitalized in the intensive care unit. Exams: erythrocytes, 4.4 million; hemoglobin, 10.6%; hematocrits, 35%; white blood cells 26,400, basophiles and myelocytes (0); segmented leukocytes, 59%; lymphocytes 30%; monocytes 2%; platelets (normal); glucose, 42mg%; urea, 73mg%; creatinine, 2.4mg%; and ECG (blockade of right branch). The patient died from cardiorespiratory insufficiency. The current report underscores the need to clarify health workers regarding the use of Sb+5 and also to remind the Health Ministry to verify the quality and origin when acquiring new products.
authors.affiliation: Núcleo de Patologia Tropical e Medicina Social, Departamento de Patologia, Universidade Federal do Maranhão, São Luis, MA, Brasil.
authors.forename: Jackson M L
authors.initials: JM
authors.lastname: Costa
authors.forename: Arnaldo M
authors.initials: AM
authors.lastname: Garcia
authors.forename: José Manuel M
authors.initials: JM
authors.lastname: Rêbelo
authors.forename: Karla M
authors.initials: KM
authors.lastname: Guimarães
authors.forename: Rossana M
authors.initials: RM
authors.lastname: Guimarães
authors.forename: Paulo M S
authors.initials: PM
authors.lastname: Nunes
mesh_terms: D000328:Adult; D000967:Antimony Sodium Gluconate / Q000009:adverse effects*; D000981:Antiprotozoal Agents / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy*; D008297:Male
chemical_list: D000981:Antiprotozoal Agents; D000967:Antimony Sodium Gluconate