Evaluation of anhydride oligomers within polymer microsphere blends and their impact on bioadhesion and drug delivery in vitro.
The effect of the addition of small molecular weight anhydride oligomers to polymer microspheres was evaluated and increased bioadhesion of the composite was demonstrated. Blends of low molecular weight anhydride oligomers with thermoplastic poly(fumaric-co-sebacic anhydride) [p(FASA)] and polycaprolactone were examined. The effects of anhydride oligomers on polymer microsphere degradation, crystallinity, and surface morphology were also explored. The results demonstrated that fumaric anhydride oligomer remained within polymer microspheres for several hours after exposure to phosphate buffer, formed a homogenous crystalline blend, increased bioadhesion as measured on rat intestine, and enhanced drug delivery in vitro as measured by the everted sac technique.
Santos
C A
CA
Spherics, Inc., Lincoln, RI 02865, USA.
Freedman
B D
BD
Ghosn
S
S
Jacob
J S
JS
Scarpulla
M
M
Mathiowitz
E
E
D000812:Anhydrides / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism*; D016503:Drug Delivery Systems; D005650:Fumarates / Q000737:chemistry / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007583:Jejunum / Q000166:cytology / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D008970:Molecular Weight; D009093:Mucus / Q000737:chemistry; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D012980:Sodium Salicylate / Q000378:metabolism; D013499:Surface Properties; D013696:Temperature; D000267:Tissue Adhesions; D014867:Water / Q000737:chemistry
D000812:Anhydrides; D001672:Biocompatible Materials; D005650:Fumarates; D011108:Polymers; D014867:Water; C032005:fumaric acid; D012980:Sodium Salicylate