title: New 1-C-(5-thio-D-xylopyranosyl) derivatives as potential orally active venous antithrombotics.
abstract: In the search for new orally active antithrombotic drugs that are metabolically stable, we explored the synthesis of 1-C-(5-thio-D-xylosyl) derivatives, examining radical and nucleophilic methods. Thus synthesized were aryl, benzyl, alkylcarboxymethylenyl, arylsulfonylmethylenyl and alkylaminocarboxymethylenyl C-linked analogues of 5-thio-D-xylopyranosides.
authors.affiliation: Laboratoires Fournier, 50 rue de Dijon, 21121, Daix, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Mignon
authors.forename: Christophe
authors.initials: C
authors.lastname: Goichot
authors.forename: Philippe
authors.initials: P
authors.lastname: Ratel
authors.forename: Gérald
authors.initials: G
authors.lastname: Cagnin
authors.forename: Michel
authors.initials: M
authors.lastname: Baudry
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Praly
authors.forename: Benaïssa
authors.initials: B
authors.lastname: Boubia
authors.forename: Véronique
authors.initials: V
authors.lastname: Barberousse
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D008956:Models, Chemical; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship; D013865:Thioglycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D013927:Thrombosis / Q000188:drug therapy; D014994:Xylose / Q000737:chemistry*
chemical_list: D005343:Fibrinolytic Agents; D013865:Thioglycosides; D014994:Xylose