title: Fully automated synthesis of O-(3-[18F]fluoropropyl)-L-tyrosine by direct nucleophilic exchange on a quaternary 4-aminopyridinium resin.
abstract: A fully automated synthesis of O-(3-[18F]fluoropropyl)-L-tyrosine (FPT), an amino acid tracer for tumor imaging with positron emission tomography, is described. FPT was prepared by a two-step reaction sequence. Direct nucleophilic fluorination substitution of [18F]fluoride with 1,3-di(4-methylphenylsulfonyloxy)propane on a quaternary 4-(4-methylpiperidinyl)pyridinium functionalized polystyrene anion exchange resin, followed by [18F]fluoro-1-(4-methylphenylsulfonyloxy)propane yielded FPT. The overall radiochemical yield with no decay correction was about 12%; the whole synthesis time was about 52 min, and the radiochemical purity was above 95%.
authors.affiliation: Nanfang PET Centre, Nan Fang Hospital, First Military Medical University, Guangzhou 510515, China. tghtgh@china.com
authors.forename: Ganghua
authors.initials: G
authors.lastname: Tang
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Tang
authors.forename: Mingfang
authors.initials: M
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Luo
authors.forename: Manquan
authors.initials: M
authors.lastname: Gan
mesh_terms: D000837:Anion Exchange Resins / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging; D011726:Pyridinium Compounds / Q000737:chemistry*; D011786:Quality Control; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification; D012371:Robotics / Q000379:methods; D014055:Tomography, Emission-Computed / Q000379:methods; D014443:Tyrosine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000837:Anion Exchange Resins; C476802:O-(3-fluoropropyl)tyrosine; D011726:Pyridinium Compounds; D019275:Radiopharmaceuticals; D014443:Tyrosine