Relations of serum interleukin 18 levels to serum lipid and glucose concentrations in an apparently healthy adult population.
OBJECTIVE
To investigate the associations between serum interleukin (IL) 18 concentrations and indices of lipid and carbohydrate metabolism in healthy adults.


METHODS
Fasting serum concentrations of IL-18, glucose, total cholesterol, triglyceride, and high- and low-density lipoprotein cholesterols were measured in 570 apparently healthy adults.


RESULTS
Univariate linear and partial regression analyses showed that the serum IL-18 concentration was positively correlated with serum triglyceride and glucose concentrations in both obese and diabetic subjects after controlling for the confounding effects of age, sex, and body mass index.


CONCLUSIONS
IL-18 may be associated with obesity and glucose intolerance.
Olusi
S O
SO
Department of Pathology, Faculty of Medicine, Kuwait University, Kuwait. olusoji@hsc.kuniv.edu.kw
Al-Awadhi
A
A
Abraham
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D003625:Data Collection; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D007730:Kuwait; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D001786:Blood Glucose; D020382:Interleukin-18; D008055:Lipids