Serum prolidase I activity and some bone metabolic markers in patients with breast cancer: in relation to menopausal status.
OBJECTIVE
The purpose of this study was to investigate the diagnostic value of some osteoblastic/osteoclastic biochemical markers and serum prolidase I activity in breast cancer (BC).


METHODS
Serum bone gla protein (BGP), prolidase I activity, urinary deoxypyridinoline (Dpy) and calcium excretions were measured, in metastatic and nonmetastatic BC patients, and in 52 healthy women.


RESULTS
In patients with metastases, bone turnover markers were found to be significantly higher than those in the control group and in patients without metastases. Serum prolidase activity in patients with and without metastases was also significantly higher than those in the control group, but there was no difference between the two patient groups.


CONCLUSIONS
Bone turnover has been suggested to be accelerated in BC patients with the more pronounced osteolytic activation, especially in metastatic state. Serum prolidase in premenopausal period appears to be valuable in discriminating cancer patients from controls. BGP and to a lesser degree of Dpy, may be useful markers for predicting the metastatic bone involvement, as well as for the more cost effective management of BC patients and monitoring the effects of antiresorptive therapy of malignant osteolysis before any metastasis could be detected by other invasive techniques.
Kir
Zeynep Ozbek
ZO
Department of Biochemistry, Istanbul Faculty of Medicine, Istanbull University, Capa, 34093 Istanbul, Turkey.
Oner
Pernur
P
Iyidoğan
Yildiz Oner
YO
Türkmen
Sembol
S
Koçak
Hikmet
H
Koşer
Murat
M
Küçücük
Seden Ozbilen
SO
D000328:Adult; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001859:Bone Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000097:blood / Q000473:pathology* / Q000652:urine; D002118:Calcium / Q000652:urine; D004150:Dipeptidases / Q000097:blood*; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D011237:Predictive Value of Tests
D000596:Amino Acids; D015415:Biomarkers; D015675:Osteocalcin; C036020:deoxypyridinoline; D004150:Dipeptidases; C022449:proline dipeptidase; D002118:Calcium