title: Ruthenium-catalyzed carbon-carbon bond formation between propargylic alcohols and alkenes via the allenylidene-ene reaction.
abstract: A novel ruthenium-catalyzed carbon-carbon bond formation between propargylic alcohols and alkenes via the allenylidene-ene reaction has been found to afford the corresponding 2,4-disubstituted-1-hexen-5-ynes in moderate yields. The finding described here discloses a new reactivity of allenylidene complexes. As a synthetic application, intramolecular cyclization of propargylic alcohols bearing an alkene moiety has been developed to give the corresponding syn-substituted chromanes in high yields with an excellent diastereoselectivity.
authors.affiliation: Department of Energy and Hydrocarbon Chemistry, Kyoto University, Sakyo-ku, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nishibayashi
authors.forename: Youichi
authors.initials: Y
authors.lastname: Inada
authors.forename: Masanobu
authors.initials: M
authors.lastname: Hidai
authors.forename: Sakae
authors.initials: S
authors.lastname: Uemura