title: Autograft ossiculoplasty in cholesteatoma surgery: is it feasible?
abstract: OBJECTIVE
  To investigate whether autologous ossicles can be safely used in ossicular reconstruction in cholesteatoma surgery after attempting cholesteatoma removal under the operating microscope.
  
  
  METHODS
  A prospective fine-section histological study of formalin-stored ossicles, harvested from cholesteatomatous ears, to evaluate for existence of residual cholesteatoma after surface disease clearance under the operating microscope.
  
  
  METHODS
  One hundred four ossicles were harvested from 76 patients with cholesteatoma for the study. These malleus heads and includes were categorized into three groups: group 1, ossicles with retained shape and useful bulk, treated by microscopic stripping alone; group 2, ossicles with retained shape and useful bulk, treated by microscopic stripping and drilling; and group 3, badly eroded ossicles, treated by microscopic stripping alone. These treated ossicles were then subjected to 4 microm histopathological study.
  
  
  RESULTS
  Residual disease was identified in 6 of the 104 ossicles. Residual disease was found only in badly eroded ossicles that are not suitable for reconstruction. All the usable ossicles were free of disease.
  
  
  CONCLUSIONS
  Autologous ossicles that have retained body and bulk are safe to use for reconstruction after surface stripping under the operating microscope. Additional burring probably adds a further margin of safety.
authors.affiliation: Department of Surgery, Prince of Wales Hospital, New Territories East Cluster, The Chinese University of Hong Kong.
authors.forename: Siu Kwan
authors.initials: SK
authors.lastname: Ng
authors.forename: William W L
authors.initials: WW
authors.lastname: Yip
authors.forename: Michael
authors.initials: M
authors.lastname: Suen
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Abdullah
authors.forename: C Andrew
authors.initials: CA
authors.lastname: van Hasselt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D018424:Cholesteatoma, Middle Ear / Q000473:pathology / Q000601:surgery*; D046508:Culture Techniques; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008307:Malleus / Q000601:surgery; D008416:Mastoid / Q000601:surgery; D008875:Middle Aged; D019933:Ossicular Replacement; D011446:Prospective Studies; D014182:Transplantation, Autologous