title: Use of HLDF-6 peptide for correction of disturbances in the endogenous opioid system in offspring of morphine-tolerant animals.
abstract: We studied the effect of bioactive peptide HLDF-6 on functional activity of the endogenous antinociceptive system in the offspring of morphine-tolerant animals. Disturbances in this system included changes in the thermonociceptive threshold and enkephalinase A activity in various brain structures. The peptide acted as a potent regulator of the homeostasis in systems responsible for the synthesis and catabolism of endogenous opioids. HLDF-6 effectively corrected disorders of the endogenous antinociceptive system.
authors.affiliation: Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov Moscow State University.
authors.forename: S V
authors.initials: SV
authors.lastname: Litvinova
authors.forename: I A
authors.initials: IA
authors.lastname: Kostanyan
authors.forename: V V
authors.initials: VV
authors.lastname: Aristova
authors.forename: A L
authors.initials: AL
authors.lastname: Kalyuzhnyi
authors.forename: V V
authors.initials: VV
authors.lastname: Shul'govskii
authors.forename: N N
authors.initials: NN
authors.lastname: Terebilina
authors.forename: L F
authors.initials: LF
authors.lastname: Panchenko
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism; D004361:Drug Tolerance / Q000502:physiology*; D005260:Female; D006706:Homeostasis; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009294:Narcotics / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D015260:Neprilysin / Q000037:antagonists & inhibitors / Q000378:metabolism; D010146:Pain / Q000378:metabolism*; D010147:Pain Measurement; D010446:Peptide Fragments / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009294:Narcotics; D009363:Neoplasm Proteins; D010446:Peptide Fragments; C091149:cell differentiation factor 8.2-kDa; D009020:Morphine; D015260:Neprilysin