title: Protective effect of carnosine on Cu,Zn-superoxide dismutase during impaired oxidative metabolism in the brain in vivo.
abstract: Natural hydrophilic antioxidant carnosine protects cerebral cytosolic Cu,Zn-superoxide dismutase (SOD) under conditions of oxidative stress in various in vivo models: short-term hypobaric hypoxia in rats and accumulation of age-related changes in senescence-accelerated mice (SAMP). Administration of carnosine preventing Cu,Zn-SOD inactivation reduced mortality in rats and prolonged average life span in SAMP-mice.
authors.affiliation: Institute of Neurology, Russian Academy of Medical Sciences, Moscow. sls@bio.inevro.msk.ru
authors.forename: S L
authors.initials: SL
authors.lastname: Stvolinskii
authors.forename: T N
authors.initials: TN
authors.lastname: Fedorova
authors.forename: M O
authors.initials: MO
authors.lastname: Yuneva
authors.forename: A A
authors.initials: AA
authors.lastname: Boldyrev
mesh_terms: D019588:Aging, Premature / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002336:Carnosine / Q000008:administration & dosage / Q000494:pharmacology*; D000860:Hypoxia / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D002336:Carnosine; D013482:Superoxide Dismutase