Lipid profile, insulin secretion, and insulin sensitivity in psoriasis.
BACKGROUND
Psoriasis has been associated with an abnormal plasma lipid metabolism and diabetes mellitus possibly related to alterations in insulin secretion and sensitivity.


OBJECTIVE
We sought to identify lipid profile, insulin secretion, and insulin sensitivity in patients with psoriasis and healthy control patients.


METHODS
A cross-sectional study was performed in 44 nonobese adults, 22 with psoriasis and 22 without. The psoriasis activity was evaluated by the psoriasis area and severity index. Insulin secretion was estimated using the homeostasis model analysis beta-cell function index. Insulin sensitivity was assessed with the insulin tolerance test.


RESULTS
High-density lipoprotein cholesterol was significantly decreased in patients with psoriasis (P =.02). There were no significant differences in insulin secretion or sensitivity in patients with psoriasis compared with control patients.


CONCLUSIONS
Patients with psoriasis had significantly decreased high-density lipoprotein cholesterol concentrations. There were no differences in insulin secretion or sensitivity compared with control patients.
Reynoso-von Drateln
Claudia
C
Medical Research Unit in Clinical Epidemiology, West National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico.
Martínez-Abundis
Esperanza
E
Balcázar-Muñoz
Blanca Rebeca
BR
Bustos-Saldaña
Rafael
R
González-Ortiz
Manuel
M
D000293:Adolescent; D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood*; D003430:Cross-Sectional Studies; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000503:physiopathology*
D008076:Cholesterol, HDL; D007328:Insulin