title: High-resolution CT findings suggest a developmental abnormality underlying superior canal dehiscence syndrome.
abstract: OBJECTIVE
  Patients with superior canal dehiscence (SCD) syndrome experience vertigo and oscillopsia with loud sounds and/or stimuli that result in changes in middle ear or intracranial pressure. Findings on temporal bone CT were analyzed to determine if a developmental abnormality is associated with the syndrome.
  
  
  METHODS
  Temporal bone CT scans [0.5 mm collimation and projections into the superior semicircular canal (SC) plane] were used to compare the bone overlying the SC in patients with SCD syndrome (20 unilateral, 7 bilateral) and in 88 patients without SCD syndrome who had undergone temporal bone CT for evaluation of other otologic disorders (controls).
  
  
  RESULTS
  The thickness of bone overlying the SC in the controls measured 0.67 +/- 0.38 mm (mean +/- SD). For individual control subjects. the thickness of bone on one side was correlated with that on the other side (r = 0.43; p < 0.0001). The thickness of bone overlying the SC on the intact side in patients with unilateral dehiscence measured 0.31 +/- 0.23 mm, and was thinner than that noted in the controls (p < 0.0001).
  
  
  CONCLUSIONS
  These findings support the notion that there is a developmental abnormality underlying SCD syndrome. When dehiscence is found on one side, the contralateral side is likely to be thin.
authors.affiliation: Laboratory of Vestibular Neurophysiology, Department of Otolaryngology-Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-0910, USA.
authors.forename: Timo P
authors.initials: TP
authors.lastname: Hirvonen
authors.forename: Noah
authors.initials: N
authors.lastname: Weg
authors.forename: S James
authors.initials: SJ
authors.lastname: Zinreich
authors.forename: Lloyd B
authors.initials: LB
authors.lastname: Minor
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007759:Labyrinth Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012665:Semicircular Canals / Q000000981:diagnostic imaging / Q000503:physiopathology; D013577:Syndrome; D013701:Temporal Bone / Q000002:abnormalities* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed