title: The early postnatal development of salivary antibody and immunoglobulin response in children orally colonized with a nonpathogenic, probiotic strain of E. coli.
abstract: The development of levels of secretory immunoglobulins (SIgs) in newborns' saliva was examined under physiological conditions and after artificial colonization with nonpathogenic, probiotic bacterial strain E. coli O83. Higher levels of secretory immunoglobulin M (SIgM) and secretory immunoglobulin A (SIgA) were detected in the saliva of breast-fed children when compared with those of bottle-fed infants. SIgM was found earlier than SIgA, the levels of both SIgM and SIgA decreased after weaning. Breastfeeding actively stimulates local immunity on mucosal membranes of newborn infants. Early mucosal colonization with nonpathogenic E. coli bacteria stimulates the mucosal immune system to produce specific antibodies as well as nonspecific secretory immunoglobulins.
authors.affiliation: 1st Department of Pediatrics, University Hospital Motol, 150 00 Prague, Czechia. vancikova@email.cz
authors.forename: Z
authors.initials: Z
authors.lastname: Vancíková
authors.forename: R
authors.initials: R
authors.lastname: Lodinová-Zádníková
authors.forename: J
authors.initials: J
authors.lastname: Radl
authors.forename: H
authors.initials: H
authors.lastname: Tlaskalová-Hogenová
mesh_terms: D000906:Antibodies / Q000032:analysis*; D001903:Bottle Feeding; D001942:Breast Feeding; D004926:Escherichia coli / Q000254:growth & development* / Q000276:immunology; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D019936:Probiotics; D012463:Saliva / Q000276:immunology*
chemical_list: D000906:Antibodies; D007071:Immunoglobulin A, Secretory; D007136:Immunoglobulins