title: [Biochemical and sonographic values in early pregnancy in women with a history of early spontaneous abortion].
abstract: BACKGROUND
  The aim of this study was to examine interconnections between changes in serum levels of biochemical parameters during pregnancy and sonographic parameters relevant for evaluation of early pregnancy.
  
  
  METHODS
  We analyzed serum levels of human chorionic gonadotropin (hCG), estradiol (E2), progesterone (PRG) and prolactin (PRL) using ELISA method, in cases of complicated pregnancies with symptoms of imminent miscarriage, and in patients with uncomplicated pregnancies. We evaluated their impact on mean gestational sac diameter (MSD), crown-rump length (CRL), inner diameter of the vitelline sac (SV), trophoblast (Trf) thickness and embryonic heart rate (STP). All results were correlated using Pearson's test and regression.
  
  
  RESULTS
  Changes in biochemical parameters of pregnancy correlate significantly with dimensions of analyzed sonographic parameters.
  
  
  CONCLUSIONS
  Levels of chorionic gonadrotropin affect production of ovarian and placental steroidogenesis. Interrelations were also discussed.
  
  
  CONCLUSIONS
  Changes in biochemical values of pregnancy hormones affect dimensions of analyzed sonographic parameters. During uncomplicated pregnancy, levels of chorionic gonadotropin, progesterone and estradiol affect mean gestation-sac diameter, embryo length, depth of trophoblast invasion and formation and function of vitelline sac, and thus they alter the embryonic heart rate.
authors.affiliation: Klinika za ginekologiju i akuserstvo, Klinicki centar, Novi Sad. anitamitreski@hotmail.com
authors.forename: Anita
authors.initials: A
authors.lastname: Mitreski
authors.forename: Gordana
authors.initials: G
authors.lastname: Radeka
mesh_terms: D000026:Abortion, Habitual / Q000097:blood / Q000175:diagnosis*; D000033:Abortion, Threatened / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D011247:Pregnancy; D016216:Ultrasonography, Prenatal
chemical_list: D015415:Biomarkers; D006728:Hormones