title: Effect of Gymnema montanum on blood glucose, plasma insulin, and carbohydrate metabolic enzymes in alloxan-induced diabetic rats.
abstract: The effects of Gymnema montanum, an endangered plant used in the ancient period of India, on blood glucose, plasma insulin, and carbohydrate metabolic enzymes were studied in alloxan diabetic rats. Administration of alcoholic extract of G. montanum leaves (50, 100, 200 mg/kg body weight) to alloxan diabetic rats for 3 weeks reduced the blood glucose level. Administration of G. montanum leaf extract (GLEt) at 200 mg/kg body weight significantly decreased the blood glucose levels and significantly increased the plasma insulin levels. This clearly shows the antidiabetic efficacy of GLEt, which was better than that of glibenclamide.
authors.affiliation: Department of Botany, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India.
authors.forename: Rajendran
authors.initials: R
authors.lastname: Ananthan
authors.forename: Muniappan
authors.initials: M
authors.lastname: Latha
authors.forename: Leelavinothan
authors.initials: L
authors.lastname: Pari
authors.forename: Kunga Mohan
authors.initials: KM
authors.lastname: Ramkumar
authors.forename: Chokkanna Gounder
authors.initials: CG
authors.lastname: Baskar
authors.forename: Vengatesh Narmatha
authors.initials: VN
authors.lastname: Bai
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D050260:Carbohydrate Metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology; D006597:Fructose-Bisphosphatase / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005905:Glyburide / Q000627:therapeutic use; D006003:Glycogen / Q000378:metabolism; D031103:Gymnema / Q000737:chemistry*; D006593:Hexokinase / Q000378:metabolism; D007328:Insulin / Q000097:blood*; D008099:Liver / Q000201:enzymology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010936:Plant Extracts; D006003:Glycogen; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase; D005905:Glyburide