title: Colonic manometry in children with defecatory disorders. role in diagnosis and management.
abstract: OBJECTIVE
  The aim of this study was to evaluate the role of colonic manometry in clarifying pathophysiology of childhood defecatory disorders and to evaluate its impact on management.
  
  
  METHODS
  We conducted a retrospective review of medical records of children referred to undergo colonic manometry to a tertiary care Motility Center from 1996 to 2001. Families were followed up a median of 20 months after evaluation (range 3-60 months).
  
  
  RESULTS
  A total of 150 colonic manometries were performed in 146 children (74 male, median age 79 months, range 4-225 months). Colonic manometry had been requested to clarify the pathophysiology of lower GI symptoms in 68%; as part of diagnostic workup for chronic intestinal pseudo-obstruction in 11%; to decide about reanastomosis of a diverted colon in 7%; and to clarify the pathophysiology of persisting symptoms after surgery for Hirschsprung's disease in 14%. Normal motility was found in the entire colon in 38% of children. In 17%, there was normal motility in the proximal colon with abnormality limited to the dilated distal colon. Abnormal motility was found in 45% of children. After colonic manometry, treatment changes were recommended in 93% of patients. We were able to follow up 65% of the families. When recommendations were followed (96% of the contacted patients), the symptoms improved in 78%, were unchanged in 18%, and were worse in 4% of patients. Among the parents, 88% believed that the suggestions given after colonic manometry had been helpful in improving their children's health.
  
  
  CONCLUSIONS
  Colonic manometry may provide information useful in guiding therapy in a subgroup of patients with defecatory disorders.
authors.affiliation: Department of Pediatrics, Division of Pediatric Gastroenterology, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
authors.forename: Licia
authors.initials: L
authors.lastname: Pensabene
authors.forename: Nader N
authors.initials: NN
authors.lastname: Youssef
authors.forename: Janet M
authors.initials: JM
authors.lastname: Griffiths
authors.forename: Carlo
authors.initials: C
authors.lastname: Di Lorenzo
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003106:Colon / Q000503:physiopathology*; D003112:Colonic Pseudo-Obstruction / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D003248:Constipation / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D003672:Defecation; D003937:Diagnosis, Differential; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology; D006627:Hirschsprung Disease / Q000150:complications / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D008365:Manometry / Q000379:methods; D012189:Retrospective Studies