The human sugar-phosphate/phosphate exchanger family SLC37.
The SLC37 family of four predicted proteins is an almost unexplored group of transmembrane sugar transporters. Of the four proteins/genes assigned to date to this family, only one is well known, the SLC37A4 gene (also known as the glucose-6-phosphate transporter 1, G6PT1) mutated in the glycogen storage disease non-1A type. Data on SLC3A1 gene expression are available for humans, while data on SLC37A2 are available for mice. The last SLC37 family member, SLC37A3, is only a putative gene/protein identified by in silico analyses. The four genes are not clustered in a single chromosome as regions and the identity of their predicted polypeptides is between 60 and 20%. Here we propose a new nomenclature for the SLC37 proteins (SPX: sugar- phosphate e xchangers) numbered according to the gene numbering.
Bartoloni
Lucia
L
University of Padova, Dept. of Medical and Surgical Sciences, via Giustiniani 2, 35100, Padova, Italy. lucia.bartoloni@unipd.it
Antonarakis
Stylianos E
SE
D001692:Biological Transport / Q000502:physiology; D050260:Carbohydrate Metabolism; D006801:Humans; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000502:physiology*; D005810:Multigene Family / Q000502:physiology; D010710:Phosphates / Q000378:metabolism*
D026901:Membrane Transport Proteins; D010710:Phosphates; C036527:SLC37A1 protein, human