Antimicrobial diterpenes from the seeds of Cephalotaxus harringtonia var. drupacea.
Six diterpenes, including two new natural products, were isolated from the seeds of Cephalotaxus harringtonia. The new metabolites were characterised as 8 beta-hydroxy-9(11),13-abietadien-12-one and 5,6-didehydroferruginol, while the known compounds were identified as ferruginol, sugiol, 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one, and abieta-8,11,13-trien-7 beta-ol. These compounds were studied in vitro for their antimicrobial activity against clinically isolated bacteria and Candida strains. Ferruginol and 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one showed antimicrobial activity against Gram-positive bacteria. None of the six diterpenes was active against the Gram-negative organisms and yeasts tested.
Politi
Matteo
M
Braca
Alessandra
A
De Tommasi
Nunziatina
N
Morelli
Ivano
I
Manunta
Antonio
A
Battinelli
Lucia
L
Mazzanti
Gabriela
G
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects; D032483:Cephalotaxus; D004224:Diterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D012639:Seeds
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D004224:Diterpenes; D010936:Plant Extracts