Post-transfusion purpura (PTP) and disseminated intravascular coagulation (DIC).
A 47-yr-old female with acute pancreatitis received four units of fresh frozen plasma because of subtle signs of disseminated intravascular coagulation (DIC). Seven days later, she developed severe thrombocytopenia. Serological studies demonstrated antibodies against HPA-1a together with pan-reactive antibodies against platelet glycoproteins (GPIIb-IIIa, GPIb-IX and GPIa-IIa), which was consistent with the diagnosis of PTP. The patient was treated with platelet transfusions, corticosteroids and intravenous immunoglobulin (IVIG) without permanent beneficial effect. After treatment with plasma exchange the platelet count increased to normal values.
Welling
Karen-Lise
KL
Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. klw@rh.dk
Taaning
Ellen
E
Lund
Birgit V
BV
Rosenkvist
Jørgen
J
Heslet
Lars
L
D016824:Antigens, Human Platelet / Q000276:immunology; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000276:immunology*; D005260:Female; D006801:Humans; D039661:Integrin beta3; D007518:Isoantibodies / Q000009:adverse effects / Q000097:blood; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications / Q000628:therapy; D010951:Plasma Exchange; D010980:Platelet Membrane Glycoproteins / Q000276:immunology; D011696:Purpura, Thrombocytopenic / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D065227:Transfusion Reaction; D016896:Treatment Outcome
D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007518:Isoantibodies; D010980:Platelet Membrane Glycoproteins