Co-ordination of Ca(2+) signalling in mammalian cells by the new Ca(2+)-releasing messenger NAADP.
Ca(2+) signalling is one of the most important means in mammalian cells of relaying the action of hormones and neurotransmitters. The great diversity of agonist-induced Ca(2+) signatures, visualized by optical imaging techniques, can be explained by the production of intracellular messengers triggering Ca(2+) release from internal stores and/or by different coupling of Ca(2+) release to Ca(2+) entry. Several messengers, such as inositol trisphosphate and cyclic ADP-ribose, have been identified to date. More recent studies have reported the important role of a newly discovered Ca(2+) releasing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). These studies have shown important interactions of these messengers in the generation of specific Ca(2+) signals. NAADP acts at a very low concentration and seems to have a key role in sensitising cyclic ADP-ribose and inositol trisphosphate receptors. These points will be discussed in the present review.
Cancela
Jose M
JM
Laboratoire de Neurobiologie cellulaire et moléculaire, CNRS UPR 9040, 1 avenue de la terrasse, 91198 Gif-sur-Yvette Cedex, France. cancela@nbcm.cnrs-gif.fr
Charpentier
Gilles
G
Petersen
Ole H
OH
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D002468:Cell Physiological Phenomena; D009249:NADP / Q000031:analogs & derivatives* / Q000502:physiology*; D015290:Second Messenger Systems / Q000502:physiology*
D009249:NADP; C024376:NAADP; D002118:Calcium