title: Infection and the risk of spontaneous cervical artery dissection: a case-control study.
abstract: OBJECTIVE
  Several constitutional and environmental risk factors may be involved in the occurrence of spontaneous cervical artery dissection (SCAD). This work explored the association between recent infection and SCAD in an hospital-based case-control study.
  
  
  METHODS
  Forty-seven patients with SCAD and 52 with ischemic stroke from another cause were prospectively and consecutively recruited by 2 neurology departments. A specially designed questionnaire was used to assess the history of an acute infection that could have occurred within a month before the vascular event.
  
  
  RESULTS
  Acute infection was more frequent in patients with SCAD (31.9%) than in control subjects (13.5%) (crude odds ratio, 3.0; 95% confidence interval, 1.1 to 8.2; P=0.032). This association was stronger in patients with multiple (odds ratio, 6.4) than single artery (odds ratio, 2.1) dissection.
  
  
  CONCLUSIONS
  Recent infection is a risk factor and could be a trigger for SCAD.
authors.affiliation: Department of Neurology, Nantes Hospital, Nantes, France. benoit.guillon@chu-nantes.fr
authors.forename: Benoît
authors.initials: B
authors.lastname: Guillon
authors.forename: Karine
authors.initials: K
authors.lastname: Berthet
authors.forename: Lamia
authors.initials: L
authors.lastname: Benslamia
authors.forename: Marion
authors.initials: M
authors.lastname: Bertrand
authors.forename: Marie-Germaine
authors.initials: MG
authors.lastname: Bousser
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
mesh_terms: D000208:Acute Disease; D000328:Adult; D002545:Brain Ischemia / Q000453:epidemiology*; D020215:Carotid Artery, Internal, Dissection / Q000453:epidemiology*; D016022:Case-Control Studies; D015984:Causality; D015897:Comorbidity; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007239:Infections / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000098:blood supply; D016017:Odds Ratio; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology*; D020217:Vertebral Artery Dissection / Q000453:epidemiology*