title: Autism and auditory brain stem responses.
abstract: OBJECTIVE
  To study a controversy that has been discussed for more than two decades: whether or not children with autism have abnormalities affecting the cochlear nerve or the auditory pathway in the brain stem and, if so, to describe these abnormalities.
  
  
  METHODS
  A group of 153 children and adolescents with autistic disorder were included in an investigation of auditory brain stem responses (ABR). Two thirds of this group, 101 individuals (75 boys, 26 girls), had normal hearing and they were selected for an in-depth ABR study. The results from the study group were compared with those of an age-matched comparison group.
  
  
  RESULTS
  The III-V interpeak latency (IPL) was significantly prolonged in both boys and girls with autism, compared with the controls. The latencies of ABR waves I and V were also significantly lengthened in the study groups. The individual test results showed that more than half of this normal-hearing autistic disorder group (58%) had abnormalities of one or more of eight ABR parameters studied. The most common abnormalities were prolongation of wave V (38%), and of I-V IPL (28%). A lengthening of the I-V IPL was also recorded in 27% of 49 children who were difficult to test or who had hearing loss. Abnormal left-right differences of ABR latencies were found in 18% of autism cases with normal hearing.
  
  
  CONCLUSIONS
  Possible causes of the reported ABR abnormalities, observed here as well as in other studies, are discussed. Brain stem lesion, occult cochlear dysfunction, and involvement of the cochlear efferent system are probable factors that can explain the ABR findings
authors.affiliation: Department of Audiology/Institution of Clinical Neurosciences, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden. ulf.rosenhall@ks.se
authors.forename: Ulf
authors.initials: U
authors.lastname: Rosenhall
authors.forename: Viviann
authors.initials: V
authors.lastname: Nordin
authors.forename: Krister
authors.initials: K
authors.lastname: Brantberg
authors.forename: Christopher
authors.initials: C
authors.lastname: Gillberg
mesh_terms: D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000150:complications / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003056:Cochlear Nerve / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D034381:Hearing Loss / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D011930:Reaction Time