Synthesis and antiviral activity of a series of new cyclohexenyl nucleosides.
A series of new cyclohexenyl nucleosides is synthesized by coupling the heterocyclic bases with a protected cyclohexenyl precursor under Mitsunobu conditions. The compounds were evaluated for their antiviral and cytostatic activity. Pronounced activity against herpes simplex virus type 1 and type 2 was observed for the 2,6-diaminopurine analogue.
Gu
Ping
P
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
Morral
Jordi
J
Wang
Jing
J
Rozenski
Jef
J
Busson
Roger
R
Van Aerschot
Arthur
A
De Clercq
Erik
E
Herdewijn
Piet
P
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003510:Cyclohexanes / Q000737:chemistry; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D003510:Cyclohexanes; D009705:Nucleosides