Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease.
Parkinson's disease is characterized by dopamine cell loss of the substantia nigra. Parkinson's disease and the neurotoxin 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine may destroy dopamine neurons through oxidative stress. Coenzyme Q is a cofactor of mitochondrial uncoupling proteins that enhances state-4 respiration and eliminate superoxides. Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys.
Horvath
Tamas L
TL
Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA. tamas.horvath@yale.edu
Diano
Sabrina
S
Leranth
Csaba
C
Garcia-Segura
Luis Miguel
LM
Cowley
Michael A
MA
Shanabrough
Marya
M
Elsworth
John D
JD
Sotonyi
Peter
P
Roth
Robert H
RH
Dietrich
Edwin H
EH
Matthews
Russel T
RT
Barnstable
Colin J
CJ
Redmond
D Eugene
DE
D000818:Animals; D002452:Cell Count; D019069:Cell Respiration / Q000187:drug effects; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D004298:Dopamine / Q000502:physiology*; D015870:Gene Expression / Q000187:drug effects; D007473:Ion Channels; D008297:Male; D026901:Membrane Transport Proteins; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins; D020734:Parkinsonian Disorders / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D011506:Proteins / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D014451:Ubiquinone / Q000494:pharmacology*; D014475:Uncoupling Agents / Q000494:pharmacology; D000071246:Uncoupling Protein 2
D007473:Ion Channels; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D011506:Proteins; D012333:RNA, Messenger; D014475:Uncoupling Agents; D000071246:Uncoupling Protein 2; D014451:Ubiquinone; D004298:Dopamine