Interactions of gamma-hydroxy butyrate with ethanol and NCS 382.
We examined the effects of gamma-hydroxy butyrate (GHB) alone and in combination with either ethanol or NCS 382 [(2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene], a purported antagonist at the GHB receptor. These effects were examined on the responding of rats under a fixed-ratio (FR) 10 schedule of sugar solution (14%, w/v; 0.1 ml) presentation. GHB dose-relatedly decreased responding. When GHB was combined with ethanol, the effects of the two drugs were less than additive. NCS 382 did not antagonize the rate-decreasing effects of GHB. These observations are consistent with the notion that many of the behavioral actions of exogenously administered GHB result from GHB's actions at sites other than the GHB receptor, and are inconsistent with the popular notion that the effects of GHB and ethanol are synergistic.
Lamb
Richard J
RJ
Department of Psychiatry, University of Texas Health Science Center at San Antonio, Mail Code 7792, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA. lamb@UTHSCSA.edu
Munn
Jaclyn
J
Duiker
Nicklaus J
NJ
Coop
Andrew
A
Wu
Huifang
H
Koek
Wouter
W
France
Charles P
CP
D000818:Animals; D001567:Benzocycloheptenes / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions / Q000502:physiology; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011930:Reaction Time / Q000187:drug effects* / Q000502:physiology; D012055:Reinforcement Schedule; D012978:Sodium Oxybate / Q000494:pharmacology*
D001567:Benzocycloheptenes; D004338:Drug Combinations; C066471:NCS 382; D000431:Ethanol; D012978:Sodium Oxybate