title: Surrogate decision-making and related issues.
abstract: This article discusses the role of surrogate decision-makers for persons who are cognitively impaired and cannot give informed consent. Questions raised follow. Is surrogate consent in research analogous to proxy consent in health care? What are some issues in surrogate consent? How does the risk-benefit ratio affect the consent process? What are the investigator's responsibilities regarding surrogate consent? Issues discussed include advance directives, durable power of attorney, legally authorized representatives, substituted judgment, double informed consent, responsibilities of surrogates, and barriers to informed consent. The article ends with recommendations to clarify state and national laws, change research designs, and establish a national mechanism for reviewing promising research that is usually prohibited.
authors.affiliation: Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Beck
authors.forename: Valorie
authors.initials: V
authors.lastname: Shue
mesh_terms: D016223:Advance Directives; D000544:Alzheimer Disease / Q000523:psychology*; D002986:Clinical Trials as Topic; D003657:Decision Making; D006801:Humans; D007258:Informed Consent; D019727:Proxy; D012107:Research Design; D012307:Risk Factors