Comparison of lipid and non-lipid markers of atherosclerosis in arterial versus venous blood.
BACKGROUND
Early studies have suggested that there may be differences in the concentration of lipoprotein particles and their associated apolipoproteins in arterial and venous blood and that this gradient might explain a proclivity to develop atherosclerotic lesions. The aim of this study was to use current methods of analysis to determine levels of these components, including particle densities and several common inflammatory markers in arterial and venous blood.


METHODS
Samples of arterial and venous blood were obtained nearly simultaneously in 26 patients undergoing right and left heart catheterization. Analyses were performed using enzymatic, immunoturbidimetric and ultracentrifugation assays.


RESULTS
Data obtained for total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, HDL and LDL particle density, high sensitivity C-reactive protein, serum amyloid-A and apoprotein B-100 concentrations in arterial and venous blood did not demonstrate any significant difference in the means.


CONCLUSIONS
Arterial and venous blood can be used interchangeably to study the effect of blood concentrations of common soluble surrogate markers of atherosclerosis.
Palmer
Bruce
B
Cardiac and Vascular Institute, Scott and White Memorial Hospital and Clinic, Scott, Sherwood and Brindley Foundation, The Texas A&M University System Health Science Center, College of Medicine, Temple, TX 76508, USA.
Watson
Linley E
LE
Riggs
Mark W
MW
Lawrence
Mark
M
Baisden
Clinton E
CE
McNeal
Catherine J
CJ
Macfarlane
Ronald D
RD
D000682:Amyloid / Q000097:blood; D016632:Apolipoprotein A-I / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D001158:Arteries; D001161:Arteriosclerosis / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014680:Veins
D000682:Amyloid; D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D015415:Biomarkers; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol