Diffusion dynamics, moments, and distribution of first-passage time on the protein-folding energy landscape, with applications to single molecules.
We study the dynamics of protein folding via statistical energy-landscape theory. In particular, we concentrate on the local-connectivity case with the folding progress described by the fraction of native conformations. We found that the first passage-time (FPT) distribution undergoes a dynamic transition at a temperature below which the FPT distribution develops a power-law tail, a signature of the intermittent nonexponential kinetic phenomena for the folding dynamics. Possible applications to single-molecule dynamics experiments are discussed.
Lee
Chi-Lun
CL
Department of Physics, State University of New York at Stony Brook, 11794, USA.
Lin
Chien-Ting
CT
Stell
George
G
Wang
Jin
J
D007700:Kinetics; D015233:Models, Statistical; D016011:Normal Distribution; D011487:Protein Conformation; D017510:Protein Folding; D013696:Temperature; D013997:Time Factors