[A novel decarboxylation method for the preparation of 5,6,7,8,10-hexahydro-5.9-methanobicyclobenzocyclooctene].
Several methods were described earlier for the synthesis of 5,6,7,8,9,10-hexahydro-5,9-methanobicyclobenzocyclooctene (5). A novel simple method is described in this paper by the persulfate (II)/silver (I) ion catalyzed decarboxylation refluxing in water-acetonitrile mixture from corresponding 4 carboxylic acid, which was prepared earlier in four steps starting from tetrahydrophthalic anhydride (1).
Csende
Ferenc
F
Arany Kereszt Gyógyszertár, Tiszavasvári, Vasvári P. u. 61.-4440. csende@elender.hu
D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis*; D034242:Cyclooctanes / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008968:Molecular Conformation
C477505:5,6,7,8,10-hexahydro-5.9-methanobicyclobenzocyclooctene; D001643:Bridged Bicyclo Compounds; D034242:Cyclooctanes; D007202:Indicators and Reagents