Negative regulation of TCR signaling and T-cell activation by selective protein degradation.
Protein degradation was previously considered to be a nonspecific cellular process that eradicated abnormal or damaged proteins. Current evidence indicates, however, that T cells use this mechanism to selectively eliminate activated T-cell receptors (TCRs) and signaling molecules, and consequently control the duration and specificity of TCR signaling.
Jang
Ihn-Kyung
IK
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
Gu
Hua
H
D000818:Animals; D018106:CD28 Antigens / Q000502:physiology; D015536:Down-Regulation; D008213:Lymphocyte Activation; D051379:Mice; D018448:Models, Immunological; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D044763:Ubiquitin-Conjugating Enzymes / Q000378:metabolism
D018106:CD28 Antigens; D011506:Proteins; D011948:Receptors, Antigen, T-Cell; D044763:Ubiquitin-Conjugating Enzymes; D011505:Protein-Tyrosine Kinases