Cyclopropyl and related analogs of the anti-HIV compound, isodideoxyadenosine.
Novel 3'-substituted isonucleoside analogs were designed on the basis of the similarities of their electrostatic potential with the active anti-HIV compound, (S,S)-isodideoxy-adenosine. The key synthetic step involved coupling between the dideoxygenated sugar derivatives, 10 and 14, and adenine under Mitsunobu conditions. Anti-HIV data are mentioned.
Nair
Vasu
V
Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, USA. vnair@rx.uga.edu
Mickle
Travis
T
Bera
Sanjib
S
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D016048:Dideoxyadenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008956:Models, Chemical; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D016048:Dideoxyadenosine