Sister chromatid exchanges and micronuclei analysis in lymphocytes of men exposed to simazine through drinking water.
In some cities of the autonomous community of Extremadura (south-west of Spain), levels of simazine from 10 to 30 ppm were detected in tap water. To analyse the possible effect of this herbicide, two biomarkers, sister chromatid exchanges (SCE) and micronuclei (MN), were used in peripheral blood lymphocytes from males exposed to simazine through drinking water. SCE and MN analysis failed to detect any statistically significant increase in the people exposed to simazine when compared with the controls. With respect to high frequency cells (HFC), a statistically significant difference was detected between exposed and control groups.
Suárez
Susanna
S
Laboratorio de Microbioloxía, Instituto de Investigación e Análises Alimentarias, Universidade de Santiago de Compostela, Campus Sur s/n, 15782 Santiago de Compostela, Spain. ssuarez@usc.es
Rubio
Arantxa
A
Sueiro
Rosa Ana
RA
Garrido
Joaquín
J
D000284:Administration, Oral; D000328:Adult; D004326:Drinking; D004781:Environmental Exposure / Q000009:adverse effects*; D006540:Herbicides / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects* / Q000235:genetics; D015162:Micronucleus Tests; D008875:Middle Aged; D012839:Simazine / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D012854:Sister Chromatid Exchange / Q000187:drug effects* / Q000235:genetics; D014874:Water Pollutants, Chemical / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D014881:Water Supply / Q000032:analysis
D006540:Herbicides; D014874:Water Pollutants, Chemical; D012839:Simazine