Estimation of concentration of chosen adhesive factors in suprarenal tumours of 'incidentaloma' type.
The role of adhesive molecules in the pathogenesis of adrenal gland tumours formation remains unclear. Here we present the concentrations of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intracellular adhesion molecule-1 (sICAM-1) in the blood of patients with adrenal "incidentaloma". We found that the mean concentrations of sVCAM and sICAM in the serum of the patients with adrenocortical cancers were significantly higher than those of the patients with benign adenomas or control cases. These results suggest that the levels of adhesion molecules may be a marker of malignancy of adrenal incidentalomas.
Kołomecki
Krzysztof
K
Department of Endocrinological and General Surgery, Institute of Endocrinology, Medical University of Lódź, 91-425 Lódź, Poland.
Stepień
Henryk
H
Stepień
Tomasz
T
Pasieka
Zbigniew
Z
Kuzdak
Krzysztof
K
D000236:Adenoma / Q000097:blood*; D000310:Adrenal Gland Neoplasms / Q000097:blood*; D000328:Adult; D002277:Carcinoma / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1