title: Giant lysosomes in the renal proximal tubules--a morphological characteristic of DBA/2 and DBA/1 mouse kidneys.
abstract: The DBA/2Cr mouse is characterized by the presence of giant lysosomes located in the proximal convoluted tubules of males and proximal straight tubules of females. However, it remains unclear whether these giant lysosomes in the proximal tubules are characteristic of DBA/2Cr specifically, or are common to other DBA/2 substrains and DBA/1. The present study investigated the morphology of kidneys from DBA/2CrSlc, DBA/2JJcl, DBA/2NCrj and DBA/1JNCrj mice of both sexes. Giant lysosomes in the renal proximal tubules were found to represent common morphological characteristic of both DBA/2 and DBA/1JN.
authors.affiliation: Department of Veterinary Anatomy, Faculty of Agriculture, Kagoshima University, 21-24 Korimoto 1, Kagoshima-shi, Kagoshima 890-0065, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Yabuki
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Hayao
authors.initials: H
authors.lastname: Nishinakagawa
authors.forename: Syusaku
authors.initials: S
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D005260:Female; D007687:Kidney Tubules, Proximal / Q000033:anatomy & histology / Q000648:ultrastructure*; D008247:Lysosomes / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA