Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization.
OBJECTIVE
Exploration of the possibility that local injury of the endometrium increases the incidence of implantation.


METHODS
Prospective study.


METHODS
Clinical IVF unit.


METHODS
A group of 134 patients, defined as good responders to hormonal stimulation, who failed to conceive during one or more cycles of IVF and embryo transfer (ET).


METHODS
The IVF treatment and ET were preceded by repeated endometrial biopsies, in a randomly selected 45 of a total of 134 patients.


METHODS
Outcome of IVF-ET treatments.


RESULTS
Transfer of a similar number of embryos (3.4 +/- 1.0 and 3.1 +/- 0.9 in the experimental and control patients, respectively) resulted in rates of implantation (27.7% vs. 14.2%, P =.00011), clinical pregnancy (66.7% vs. 30.3%, P =.00009), and live births per ET (48.9% vs. 22.5%, P =.016) that were more than twofold higher in the experimental group as compared to controls.


CONCLUSIONS
These results suggest that IVF treatment that is preceded by endometrial biopsy doubles the chance for a take-home baby.
Barash
Amihai
A
IVF Unit, Department of Obstetrics and Gynecology, Kaplan Medical Center (Affiliated to the Medical School of the Hebrew University and Hadassah, Jerusalem), Israel.
Dekel
Nava
N
Fieldust
Sheila
S
Segal
Ilana
I
Schechtman
Edna
E
Granot
Irit
I
D000328:Adult; D001706:Biopsy; D003656:Decidua / Q000502:physiology; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium / Q000293:injuries* / Q000473:pathology; D005260:Female; D005307:Fertilization in Vitro; D006632:Histamine / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011446:Prospective Studies
D006632:Histamine