title: Multimodality treatments with endoscopic mucosal resection of esophageal squamous cell carcinoma with submucosal invasion.
abstract: OBJECTIVE
  A standard treatment for esophageal squamous cell carcinoma (SCC) with submucosal invasion is considered to be radical resection at present. In this study, we evaluated the efficacy of multimodality treatments with endoscopic mucosal resection (EMR) of esophageal SCC with submucosal invasion.
  
  
  METHODS
  Eighteen cases of SCC with submucosal invasion were treated with EMR. Lymphatic invasion was found in 11 cases (67%), and there were no cases of blood vessel invasion. EMR was performed prior to any other treatment. Chemotherapy and/or radiotherapy were added if indicated by the histopathological features.
  
  
  RESULTS
  There were no cases of local recurrence. Lymph-node recurrence was detected in 1 case treated with EMR alone. There were no cases of cancer death. The overall survival rate was 83% in all patients.
  
  
  CONCLUSIONS
  Multimodality treatments with EMR were effective in treating esophageal SCC with submucosal invasion.
authors.affiliation: Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Kawada-cho 8-1, Shinjuku-ku, Tokyo 162-8666, Japan. masaho@juno.dti.ne.jp
authors.forename: M
authors.initials: M
authors.lastname: Ota
authors.forename: H
authors.initials: H
authors.lastname: Ide
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Murata
authors.forename: R
authors.initials: R
authors.lastname: Eguchi
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Narumiya
authors.forename: I
authors.initials: I
authors.lastname: Oi
authors.forename: K
authors.initials: K
authors.lastname: Takasaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology / Q000601:surgery*; D009361:Neoplasm Invasiveness; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate; D016896:Treatment Outcome