Graft-versus-tumor effect in a patient with advanced neuroblastoma who received HLA haplo-identical bone marrow transplantation.
A 5-year-old boy received CD34-positive HLA haplo-identical bone marrow transplantation from his father as treatment for refractory advanced neuroblastoma. He had residual disease in the para-aortic lymph nodes and multiple bones after the transplant. However, all of his residual disease had disappeared completely 3 years later. He developed grade I acute graft-versus-host disease (GVHD) but had no symptoms of chronic GVHD or any other complications. This case demonstrates the possibility of a graft-versus-tumor effect against neuroblastoma by HLA-mismatched allogeneic hematopoietic stem cell transplantation.
Inoue
M
M
Department of Pediatrics, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan.
Nakano
T
T
Yoneda
A
A
Nishikawa
M
M
Nakayama
M
M
Yumura-Yagi
K
K
Sakata
N
N
Yasui
M
M
Okamura
T
T
Kawa
K
K
D016026:Bone Marrow Transplantation / Q000276:immunology*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D002675:Child, Preschool; D018572:Disease-Free Survival; D006086:Graft vs Host Disease; D020350:Graft vs Tumor Effect / Q000276:immunology*; D006239:Haplotypes; D006648:Histocompatibility; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D018365:Neoplasm, Residual / Q000175:diagnosis; D009447:Neuroblastoma / Q000473:pathology / Q000628:therapy*; D011877:Radionuclide Imaging; D014185:Transplantation, Isogeneic