Chick receptor tyrosine phosphatase Psi is dynamically expressed during somitogenesis.
To study the role of receptor tyrosine phosphatases in vertebrate development, in particular somitogenesis, we have cloned chick receptor tyrosine phosphatase Psi (cRPTPPsi). cRPTPPsi is expressed in a dynamic fashion in the somites to-be-formed and uniformly throughout the presomitic mesoderm. In differentiating somites, cRPTPPsi expression gets restricted to the dermomyotome. In addition cRPTPPsi is expressed in the developing intermediate mesoderm, in neurogenic and sensory organs, the limb bud and the developing heart.
Aerne
Birgit
B
Developmental Genetics Laboratory, Cancer Research UK, Lincoln's Inn Fields, WC2A 3PX London, UK. birgit.aerne@cancer.org.uk
Stoker
Andrew
A
Ish-Horowicz
David
D
D000595:Amino Acid Sequence; D000818:Animals; D002642:Chick Embryo; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D017027:Protein Tyrosine Phosphatases / Q000096:biosynthesis / Q000235:genetics*; D016415:Sequence Alignment; D019170:Somites / Q000378:metabolism*
D017027:Protein Tyrosine Phosphatases