[Vasculogenesis and angiogenesis: molecular and cellular controls. part I: growth factors].
Angiogenesis characterizes embryonic development, but occurs also in adulthood, under physiological circumstances like adaptation to muscular exercise or in pathology like cancers. Knowledge of these mechanisms has step forward partly due to knock-out mice that have allowed to devoid an exact role to the different growth factors that are involved. Interestingly, the same growth factors and their receptors are equally involved during development and adulthood. We have detailed here their respective role and how interactions between them leads to a newly formed vessel.
Kubis
N
N
Service d'Explorations Fonctionnelles Multidisciplinaires, Pr. Lévy et Unité INSERM 541, Dr. Tedgui, Hôpital Lariboisière, 2, rue Ambroise Paré, 75010 Paris, France.
Levy
B I
BI
D000818:Animals; D001808:Blood Vessels / Q000502:physiology*; D006133:Growth Substances / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000098:blood supply; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000502:physiology*
D006133:Growth Substances