title: Liver transplantation for hepatopulmonary syndrome: a ten-year experience in Paris, France.
abstract: BACKGROUND
  Although the possibility of reversing hepatopulmonary syndrome (HPS) after liver transplantation is now well established, the proportion of patients in whom reversibility is observed and the time to resolution of HPS remain uncertain.
  
  
  METHODS
  We analyzed the outcome of all adult patients with HPS who underwent orthotopic liver transplantation in all the liver transplant centers in Paris, during a 10-year period.
  
  
  RESULTS
  Twenty-three adult patients (median age, 47 years; range, 14-64) underwent transplantation in four institutions. Median PaO(2) was 52 (range, 32-67) mm Hg and median alveolar-arterial oxygen gradient was 66 mm Hg. When patients were breathing 100% O(2), median PaO(2) was 310 (range, 74-663) mm Hg. Median isotopic shunt ratio was 33% (range, 0-80%). The overall mortality during the study period was 30.5% (7/23). Perioperative mortality was 8.5%, whereas late mortality was 22%. None of the preoperative characteristics of HPS (isotopic shunt ratio, PaO(2) on room air or on 100% oxygen) was associated with overall postoperative mortality. Of the 21 patients surviving the perioperative period (median follow-up, 17 months; range, 0.5-72), a decrease in alveolar-arterial oxygen gradient of at least 5 mm Hg and at least 10 mm Hg was observed in 21 of 21 and in 18 of 21 patients, respectively, with great variations in the time of improvement. The threshold of 70 mm Hg was reached in 15 patients. The lower the preoperative PaO(2), the longer the time to reach this point.
  
  
  CONCLUSIONS
  Our data strongly support the role of orthotopic liver transplantation in adult patients with HPS, regardless of its severity.
authors.affiliation: Service de Pneumologie et de Reéanimation Respiratoire et INSERM U408, Service d'Hepatologie, Service de Chirurgie Digestive, Hôpital Beaujon, Clichy, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Taillé
authors.forename: Jacques
authors.initials: J
authors.lastname: Cadranel
authors.forename: Agnès
authors.initials: A
authors.lastname: Bellocq
authors.forename: Gabriel
authors.initials: G
authors.lastname: Thabut
authors.forename: Olivier
authors.initials: O
authors.lastname: Soubrane
authors.forename: François
authors.initials: F
authors.lastname: Durand
authors.forename: Philippe
authors.initials: P
authors.lastname: Ichaï
authors.forename: Christophe
authors.initials: C
authors.lastname: Duvoux
authors.forename: Jacques
authors.initials: J
authors.lastname: Belghiti
authors.forename: Yvon
authors.initials: Y
authors.lastname: Calmus
authors.forename: Hervé
authors.initials: H
authors.lastname: Mal
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D020065:Hepatopulmonary Syndrome / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D012189:Retrospective Studies
chemical_list: D010100:Oxygen