Antimutagenic and antioxidant activities of crown compounds in comparison with the effects of garlic extract.
Antimutagenic activity of N-carboxyalkyl derivatives of aza- and benzoazacrown compounds was revealed and antimutagenic activity of garlic extract was confirmed. Specific genoprotective effect of crown compounds towards the effects of various mutagens was demonstrated. The antimutagenic effect of these compounds was not realized via antioxidant mechanisms, while the protective effect of garlic extract was associated with its antioxidant and reparative activities.
Zasukhina
G D
GD
Institute of General Genetics, Russian Academy of Sciences, Moscow.
Vasil'eva
I M
IM
Mikhal'chik
E S
ES
Durnev
A D
AD
Gromov
S P
SP
Fedorova
O A
OA
Alfimov
M V
MV
D016587:Antimutagenic Agents / Q000378:metabolism* / Q000494:pharmacology; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D002460:Cell Line; D043844:Crown Ethers / Q000378:metabolism* / Q000494:pharmacology; D004247:DNA / Q000187:drug effects; D004249:DNA Damage; D005737:Garlic / Q000737:chemistry*; D006801:Humans; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects; D010936:Plant Extracts / Q000378:metabolism* / Q000494:pharmacology
D016587:Antimutagenic Agents; D000975:Antioxidants; D043844:Crown Ethers; D010936:Plant Extracts; D004247:DNA