Localization of thioredoxin-interacting protein (TXNIP) mRNA in epithelium of human gastrointestinal tract.
Thioredoxin-interacting protein (TXNIP) is a negative regulator of thioredoxin. However, its role in the gastrointestinal (GI) epithelium is as yet unknown. Using in situ hybridization, we demonstrated that mRNA of TXNIP was differentially expressed in the epithelium of the human GI tract. TXNIP transcript was especially prominent in terminal differentiated cells. TXNIP was also highly expressed in lymphocytes in the lymphoid follicles. Our results suggest a new potential role of TXNIP in the differentiation of epithelial cells and in mucosal immunity of the GI tract.
Takahashi
Yasuo
Y
Division of Genetic and Genomic Medicine, Medical Research Center, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo 173-8610, Japan. yasuot@med.nihon-u.ac.jp
Ishii
Yukimoto
Y
Murata
Akiko
A
Nagata
Toshihito
T
Asai
Satoshi
S
D000368:Aged; D002352:Carrier Proteins / Q000378:metabolism*; D005753:Gastric Mucosa / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D017403:In Situ Hybridization; D007413:Intestinal Mucosa / Q000166:cytology / Q000378:metabolism*; D007420:Intestine, Large / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism*; D013879:Thioredoxins / Q000378:metabolism*
D002352:Carrier Proteins; D012333:RNA, Messenger; C486715:TXNIP protein, human; C082634:cytosolic-nuclear tumor promoter binding protein; D013879:Thioredoxins