Protective effect of carnosine on Cu,Zn-superoxide dismutase during impaired oxidative metabolism in the brain in vivo.
Natural hydrophilic antioxidant carnosine protects cerebral cytosolic Cu,Zn-superoxide dismutase (SOD) under conditions of oxidative stress in various in vivo models: short-term hypobaric hypoxia in rats and accumulation of age-related changes in senescence-accelerated mice (SAMP). Administration of carnosine preventing Cu,Zn-SOD inactivation reduced mortality in rats and prolonged average life span in SAMP-mice.
Stvolinskii
S L
SL
Institute of Neurology, Russian Academy of Medical Sciences, Moscow. sls@bio.inevro.msk.ru
Fedorova
T N
TN
Yuneva
M O
MO
Boldyrev
A A
AA
D019588:Aging, Premature / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002336:Carnosine / Q000008:administration & dosage / Q000494:pharmacology*; D000860:Hypoxia / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism*
D000975:Antioxidants; D002336:Carnosine; D013482:Superoxide Dismutase