Regulation and function of serine kinase networks in lymphocytes.
Recent technological developments have facilitated explorations of the sustained signalling pathways important for lymphocyte activation. One key response necessary for lymphocyte activation is the prolonged activation of the lipid kinase phosphatidylinositol-3 kinase (PI3K). It has also been shown that there is sustained activation of diverse serine/threonine kinases in activated lymphocytes.
Cantrell
Doreen A
DA
Division of Cell Biology and Immunology, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK. doreen.cantrell@cancer.org.uk
D000818:Animals; D019852:Diacylglycerol Kinase / Q000378:metabolism; D050356:Lipid Metabolism; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000201:enzymology* / Q000276:immunology; D015513:Oncogene Proteins / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism / Q000502:physiology*; D051057:Proto-Oncogene Proteins c-akt; D015398:Signal Transduction
D015513:Oncogene Proteins; D018129:Phosphatidylinositol Phosphates; C060974:phosphatidylinositol 3,4,5-triphosphate; D019852:Diacylglycerol Kinase; C491754:AKT3 protein, human; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt