title: Correlates of sensitization to Blomia tropicalis and Dermatophagoides pteronyssinus in asthma in Barbados.
abstract: BACKGROUND
  Sensitivity to the mite Blomia tropicalis is related to asthma in tropical climates, but correlates of sensitivity to B. tropicalis and its relationship to Dermatophagoides pteronyssinus sensitivity have not been widely examined in families with asthma. The main objective of this study was to determine prevalence and correlates of sensitivity to these mites in families with asthma and characteristics of persons sensitized to both.
  
  
  METHODS
  Antibodies to major antigens (Blo t 5 and Der p 1) of these mites were measured by immunochemiluminescent assay in 481 members of 29 families from Barbados ascertained through two asthmatic siblings.
  
  
  RESULTS
  Blo t 5 sensitivity was present in 261 subjects (46%) and was associated with younger age, higher total serum IgE level, and more than a three-fold increased prevalence of asthma (42 vs. 13%). Der p 1 sensitivity was less common (27%) and showed similar associations with age, IgE, and asthma. Of the 261 subjects sensitized to Blo t 5, 116 were also sensitized to Der p 1; they were younger, had higher total and Blo t 5 specific IgE levels, and had more than twice the asthma prevalence as those sensitized to Blo t 5 alone (59 vs. 29%). Der p 1 sensitivity without Blo t 5 sensitivity was uncommon; 90% of those sensitized to Der p 1 were also sensitized to Blo t 5. Geometric mean total IgE levels were lowest in the 207 participants without any mite sensitization (102 U/ml), intermediate in 158 sensitized to either Blo t 5 OR Der p 1 (609 U/ml), and highest in 116 sensitized to both (1,869 U/ml).
  
  
  CONCLUSIONS
  Blo t 5 is the predominant sensitizing mite allergen in these Barbadian families with correlates similar to Der p 1. Concomitant sensitization to Der p 1 appears to identify a more reactive subgroup of individuals at a higher risk of asthma.
authors.affiliation: Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD 20892-7934, USA. manolio@nih.gov
authors.forename: Teri A
authors.initials: TA
authors.lastname: Manolio
authors.forename: Kathleen C
authors.initials: KC
authors.lastname: Barnes
authors.forename: Raana P
authors.initials: RP
authors.lastname: Naidu
authors.forename: Paul N
authors.initials: PN
authors.lastname: Levett
authors.forename: Terri H
authors.initials: TH
authors.lastname: Beaty
authors.forename: Alexander F
authors.initials: AF
authors.lastname: Wilson
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology; D039741:Antigens, Dermatophagoides / Q000276:immunology; D052179:Antigens, Plant; D001249:Asthma / Q000453:epidemiology / Q000276:immunology*; D001460:Barbados / Q000453:epidemiology; D002648:Child; D003710:Demography; D040002:Dermatophagoides pteronyssinus / Q000276:immunology; D005190:Family; D005260:Female; D006801:Humans; D007109:Immunity / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D015995:Prevalence; D039981:Pyroglyphidae / Q000276:immunology*
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides; D052179:Antigens, Plant; C094701:allergen Blo t 5; D007073:Immunoglobulin E