Inactivated suckling mouse brain rabies vaccine provides short-term immunity in capuchin monkeys (Cebus apella).
Eight capuchin monkeys (Cebus apella) were vaccinated against rabies with an inactivated suckling mouse brain vaccine (SMBV). Three 1-ml doses of 2% brain tissue suspension were given by i.m. injection at 0, 30, and 60 days. Blood samples were collected at 0, 30, 60, 90, 150, 210, 240, 300, and 365 days and were tested by simplified fluorescence inhibition to titer-neutralizing antibodies. All of the animals developed neutralizing antibodies with titers >0.5 IU/ml after vaccination, but the immune response persisted for only 122.3 +/- 32.6 days. The SMBV was able to induce immune response in the capuchin monkeys, but protection was short-lived.
Passos
E C
EC
Instituto Pasteur, Av. Paulista, 393, São Paulo, SP, Brazil 01311-000.
Germano
P M
PM
Guimarães
M A
MA
Fedullo
J D
JD
Corrêa
S H
SH
Consales
C A
CA
Carrieri
M L
ML
Gonçalves
M A
MA
D000818:Animals; D000833:Animals, Suckling; D000836:Animals, Zoo; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D001921:Brain; D002428:Cebus / Q000276:immunology*; D005260:Female; D007115:Immunization Schedule; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D051379:Mice; D008992:Monkey Diseases / Q000517:prevention & control*; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
D000914:Antibodies, Viral; D011819:Rabies Vaccines; D015164:Vaccines, Inactivated