title: Synthesis of a novel cis-proline-derived cyclic type VI beta-turn mimic via ring-closing metathesis.
abstract: A cis-proline derived cyclic mimic of a type VI beta-turn is synthesized via a ring-closing metathesis reaction. The solution NMR conformational study indicates that the major conformer of the cyclic peptide adopts a type VIa beta-turn in CDCl(3) and a type VIb beta-turn in DMSO-d(6).
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India.
authors.forename: Anima
authors.initials: A
authors.lastname: Boruah
authors.forename: I Nageshwar
authors.initials: IN
authors.lastname: Rao
authors.forename: Jyoti Prokash
authors.initials: JP
authors.lastname: Nandy
authors.forename: S Kiran
authors.initials: SK
authors.lastname: Kumar
authors.forename: A C
authors.initials: AC
authors.lastname: Kunwar
authors.forename: Javed
authors.initials: J
authors.lastname: Iqbal
mesh_terms: D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D011392:Proline / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013237:Stereoisomerism
chemical_list: D010456:Peptides, Cyclic; D011392:Proline