Antimutagenic activity of 8-hydroxyisoflavones and 6-hydroxydaidzein from soybean miso.
The antimutagenic activity of four isoflavones isolated from soybean miso toward three kinds of mutagens, AF-2, MNNG, and Trp-P-1, was evaluated by the Ames test. 8-Hydroxyisoflavones had greater suppressive potency than that of daidzein, and 6-hydroxydaidzein had almost the same activity as daidzein. These results indicated the number of hydroxy and methoxy groups and the position of these functional groups were important for antimutagenic activity.
Chen
Yu-chi
YC
Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan.
Inaba
Miyuki
M
Abe
Naoki
N
Hirota
Akira
A
D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology; D004336:Drug Antagonism; D016166:Free Radical Scavengers; D005668:Furylfuramide / Q000494:pharmacology; D007529:Isoflavones / Q000737:chemistry / Q000494:pharmacology*; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009153:Mutagens / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000187:drug effects; D013025:Glycine max / Q000737:chemistry*; D013329:Structure-Activity Relationship
D016587:Antimutagenic Agents; D002243:Carbolines; D016166:Free Radical Scavengers; D007529:Isoflavones; D009153:Mutagens; D005668:Furylfuramide; D008769:Methylnitronitrosoguanidine; C004742:daidzein; C019132:3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole; C476812:6-hydroxydaidzein