[Severe pre-eclampsia and fetal trisomy 13 in a multiparous woman].
Preeclampsia (PE) is a common clinical syndrome often seen in nulliparae and a major cause of maternal and neonatal morbidity and mortality. Genetic predisposition and abnormal trophoblastic function may contribute to the pathophysiology of PE. The association between trisomy 13 and PE might be suggestive for a causative effect of some fetal genes encoded on chromosome 13, predisposing for the development of PE. We here report a case of severe PE in a multiparous woman carrying a trisomy 13 fetus.
Pedersen
Berit Woetmann
BW
Gynaekologisk-obstetrisk Afdeling, Amtssygehuset i Gentofte, DK-2900 Hellerup. bwp@dadlnet.dk
Grønlund
Annelise
A
D000015:Abnormalities, Multiple / Q000196:embryology / Q000235:genetics; D000328:Adult; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010298:Parity; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D014314:Trisomy / Q000235:genetics*