Pyometra and uterine adenocarcinoma in a melengestrol acetate-implanted captive coati (Nasua nasua).
A 9-yr and 3-mo-old captive female coati (Nasua nasua) was implanted with melengestrol acetate for contraception for 4.5 yr prior to presentation. During her annual examination, purulent vaginal discharge and a palpably prominent uterus were identified. Ancillary diagnostic tests including hematology, cystocentesis, radiographs, and abdominal ultrasound were consistent with pyometra. An ovariohysterectomy was performed and histologic examination revealed pyometra and uterine adenocarcinoma, similar to pathology that has been associated with melengestrol acetate contraception in felids, canids, and primates. Given the potential association between melengestrol acetate and uterine pathology in this case, we recommend caution with melengestrol acetate use in procyonids.
Chittick
E
E
Environmental Medicine Consortium, Department of Clinical Sciences, North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.
Rotstein
D
D
Brown
T
T
Wolfe
B
B
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D000818:Animals; D000836:Animals, Zoo; D002335:Carnivora; D004343:Drug Implants; D017809:Fatal Outcome; D005260:Female; D007044:Hysterectomy / Q000662:veterinary; D008552:Melengestrol Acetate / Q000008:administration & dosage / Q000009:adverse effects*; D010052:Ovariectomy / Q000662:veterinary; D045167:Progesterone Congeners / Q000008:administration & dosage / Q000009:adverse effects*; D012086:Reoperation / Q000662:veterinary; D013492:Suppuration / Q000139:chemically induced / Q000473:pathology / Q000601:surgery / Q000662:veterinary; D014591:Uterine Diseases / Q000139:chemically induced / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D014594:Uterine Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000601:surgery / Q000662:veterinary*
D004343:Drug Implants; D045167:Progesterone Congeners; D008552:Melengestrol Acetate