Impact of iron loading on the activity of isoniazid or ethambutol in the treatment of murine tuberculosis.
OBJECTIVE
To assess the impact of iron loading on the activity of isoniazid and ethambutol in the treatment of murine tuberculosis.


METHODS
Iron-loaded and iron-normal female Balb/C mice infected with 1.5 x 10(7) colony forming units of Mycobacterium tuberculosis were treated with either isoniazid or ethambutol for 28 days.


RESULTS
For both treatments, the outcome was impaired by the iron loading: bactericidal activity of isoniazid was partially but significantly reduced and ethambutol bactericidal activity was totally inhibited.


CONCLUSIONS
The treatment of tuberculosis in patients with iron loading should be longer than for normal patients or should contain an additional drug.
Lounis
N
N
Laboratoire de Bactériologie, Faculté de Médecine Pitié-Salpêtrière, Paris, France. nacerlounis@yahoo.fr
Maslo
C
C
Truffot-Pernot
C
C
Grosset
J
J
Boelaert
R J
RJ
D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004347:Drug Interactions; D004977:Ethambutol / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D007501:Iron / Q000494:pharmacology*; D007538:Isoniazid / Q000494:pharmacology* / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D014376:Tuberculosis / Q000188:drug therapy* / Q000401:mortality
D000995:Antitubercular Agents; D004977:Ethambutol; D007501:Iron; D007538:Isoniazid