title: Sesquiterpene constituents from the liverwort Bazzania japonica.
abstract: The hydrodistillation products of the liverwort Bazzania japonica were separated by preparative gas chromatography (GC) and investigated by spectroscopic methods. Seven unknown compounds were isolated and identified by GC-MS and NMR. Four of them, the norsesquiterpene hydrocarbons 4-epi-11-nor-aristola-1(10),11-diene (1), 4-epi-11-nor-aristola-1,9,11-triene (2), 4-epi-11-nor-aristola-9,11-diene (3), and one oxygenated sesquiterpene, (-)-aristol-1(10)-en-12-ol (5) are new natural compounds, and one, (+)-himachala-2,4-diene (7), has for the first time been isolated from liverworts. The absolute configurations of 5 and 7 were derived by chemical correlation reactions and/or enantioselective GC using cyclodextrin phases. 1, 2 and 3 have identical absolute configuration.
authors.affiliation: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Key Laboratory for Natural Medicine of Gansu Province, 342 Tianshui Road, Lanzhou 730000, China.
authors.forename: Runhua
authors.initials: R
authors.lastname: Lu
authors.forename: Claudia
authors.initials: C
authors.lastname: Paul
authors.forename: Simla
authors.initials: S
authors.lastname: Basar
authors.forename: Wilfried A
authors.initials: WA
authors.lastname: König
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry; D035926:Hepatophyta / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000032:analysis* / Q000737:chemistry
chemical_list: D012717:Sesquiterpenes