The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents.
Carlomagno
Teresa
T
Max-Planck-Institut für Biophysikalische Chemie, Am Fassberg 11, 37 077 Göttingen, Germany. taco@nmr.mpibpc.mpg.de
Blommers
Marcel J J
MJ
Meiler
Jens
J
Jahnke
Wolfgang
W
Schupp
Thomas
T
Petersen
Frank
F
Schinzer
Dieter
D
Altmann
Karl-Heinz
KH
Griesinger
Christian
C
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D002417:Cattle; D034261:Epothilones / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012996:Solutions / Q000737:chemistry; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000737:chemistry*
D000970:Antineoplastic Agents; D034261:Epothilones; D012996:Solutions; D014404:Tubulin; C093787:epothilone A