Four week feeding toxicity study with phenylphosphinic acid in rats.
Phenylphosphinic acid was fed in graded concentrations of either 0 (control), 100, 1,000, or 10,000 ppm to rats for 28 days. These concentrations provided average daily doses of 8, 76, and 779 mg/kg (males) and 9, 83, and 859 mg/kg (females). No signs of adverse response were detected at any concentration up to the highest levels tested, 10,000 ppm or 779 (male) or 859 (female) mg/kg. Parameters measured were clinical signs, growth, neurobehavior, ophthalmology, and clinical and anatomical pathology. Phenylphosphinic acid is very low in toxicity following 31 days of feeding to the rat.
Donner
E Maria
EM
DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714-0050, USA. maria.donner@usa.dupont.com
Kennedy
Gerald L
GL
Stadler
Judith S
JS
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004822:Epididymis / Q000033:anatomy & histology / Q000187:drug effects; D005123:Eye / Q000187:drug effects; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007668:Kidney / Q000033:anatomy & histology / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D010721:Phosphinic Acids / Q000633:toxicity*; D011517:Prothrombin Time; D051381:Rats; D036401:Toxicity Tests, Chronic; D014556:Urine / Q000737:chemistry
D006454:Hemoglobins; D010721:Phosphinic Acids; C480970:phenylphosphinic acid