Cyclic amine sulfonamides as linkers in the design and synthesis of novel human beta(3) adrenergic receptor agonists.
Piperidine, pyrrolidine, and azetidine sulfonamides were examined as linkers in designing novel human beta(3) adrenergic receptor (beta(3)-AR) agonists. The azetidine derivative 37, and piperidine derivatives 7, 8, and 13 were found to be potent beta(3)-AR agonists and have good selectivity against beta(1)- and beta(2)-AR.
Sum
Fuk Wah
FW
Chemical Sciences, Wyeth Research, 10965, Pearl River, NY, USA. sums@wyeth.com
Wong
Victoria
V
Han
Stella
S
Largis
Elwood
E
Mulvey
Ruth
R
Tillett
Jeff
J
D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D001384:Azetidines / Q000138:chemical synthesis / Q000494:pharmacology; D016466:CHO Cells; D006224:Cricetinae; D003500:Cyclization; D015195:Drug Design; D006801:Humans; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000494:pharmacology; D013449:Sulfonamides / Q000737:chemistry*
D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists; D001384:Azetidines; D010880:Piperidines; D011759:Pyrrolidines; D013449:Sulfonamides