Sequencing the genome from nematode to human: changing methods, changing science.
The history of science tends to be recounted as a story of progress from early goals and discoveries to a unified outcome, in some sense implicit from the beginning, and often due to technological advances. The sequencing of the human genome is no exception. As a crucial part of the Human Genome Project, the history of genomic sequencing is typically presented as a direct result of the discoveries of the structure of DNA and its coding function, together with practical factors such as the development of techniques which made large-scale sequencing possible. However, the history of sequencing is inevitably a more complicated story, not only about molecular biology, but also about the evolving culture of scientific practice at the end of the 20th century.
Ankeny
Rachel A
RA
Unit for History and Philosophy of Science, Carslaw F07, University of Sydney 2006, NSW, Australia. rankeny@science.usyd.edu.au
D000818:Animals; D002874:Chromosome Mapping / Q000266:history; D004247:DNA / Q000266:history; D005826:Genetics, Medical / Q000266:history*; D015894:Genome, Human; D049673:History, 20th Century; D016045:Human Genome Project / Q000266:history*; D006801:Humans; D017422:Sequence Analysis, DNA; D006113:United Kingdom
D004247:DNA