title: Auxiliary partial orthotopic liver transplantation for fulminant hepatitis: regeneration of the diseased native liver in a pig model.
abstract: BACKGROUND
  This study was performed to develop a clinically relevant porcine model of auxiliary partial orthotopic liver transplantation (APOLT) for fulminant hepatic failure.
  
  
  METHODS
  FHF was induced by intraportal administration of alpha-amanitin and lipopolysaccharide. Thereafter, pigs were divided into four groups. Group 1 was an untreated, control group. In group 2, pigs underwent only a left hemihepatectomy. Pigs in groups 3 and 4 received APOLT after hemihepatectomy. Tacrolimus was administered to pigs in group 4, but not to those in group 3.
  
  
  RESULTS
  Two-week survival rates were 0%, 20%, 40%, and 100% for groups 1, 2, 3, and 4, respectively. In group 4, after abolishing the graft function at 1 week, pigs survived for more than 2 weeks, and regeneration of the native liver was confirmed histologically.
  
  
  CONCLUSIONS
  Pigs suffering from fulminant hepatic failure could achieve long survival and liver regeneration with a temporary support of the auxiliary graft.
authors.affiliation: Graduate School of Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Ishiguro
authors.forename: Yasutsugu
authors.initials: Y
authors.lastname: Takada
authors.forename: Mei
authors.initials: M
authors.lastname: Gu
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Fukunaga
authors.forename: Hdeki
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Seino
authors.forename: Toru
authors.initials: T
authors.lastname: Kawamoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Yuzawa
authors.forename: Masaaki
authors.initials: M
authors.lastname: Otsuka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Todoroki
authors.forename: Katashi
authors.initials: K
authors.lastname: Fukao
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006085:Graft Survival; D006505:Hepatitis / Q000601:surgery; D008099:Liver / Q000502:physiology* / Q000601:surgery; D017093:Liver Failure / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods* / Q000401:mortality; D008297:Male; D012038:Regeneration; D015996:Survival Rate; D013552:Swine