The future of psychiatric genetics.
Geneticists have been predicting that advances in their discipline will revolutionize the understanding of human disease and behavior. While there has been considerable progress in disorders showing simple, Mendelian patterns of inheritance, expectations have yet to be fulfilled for disorders and traits showing complex inheritance. In this article, we consider the difficulties that complex diseases pose to genetic research, discuss progress and make suggestions regarding future directions.
van den Bree
Marianne B M
MB
Department of Psychological Medicine, University of Wales, College of Medicine, Heath Park, Cardiff CF14 4XN, UK. vandenbreemb@cf.ac.uk
Owen
Michael J
MJ
D000818:Animals; D003863:Depression / Q000235:genetics; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D023421:Models, Animal; D008967:Molecular Biology; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000502:physiology