Formation of neural precursor cell populations by differentiation of embryonic stem cells in vitro.
Recent interest in the generation of neural lineages by differentiation of embryonic stem cells arises from the opportunities represented by a developmentally normal, unlimited source of material that can be manipulated genetically with precision. Several experimental approaches, which differ conceptually, in the route of differentiation and the characteristics of the resulting cell population have been reported. In this review we undertake a comparative analysis of these approaches and their suitability for experimental investigation or implantation.
Rathjen
Joy
J
Department of Molecular Biosciences, and 2ARC SRC for Molecular Genetics of Development, Adelaide University, Australia. joy.rathjen@adelaide.edu.au
Rathjen
Peter D
PD
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology*; D019070:Cell Lineage / Q000187:drug effects / Q000502:physiology; D002469:Cell Separation / Q000379:methods; D006801:Humans; D007381:Intermediate Filament Proteins / Q000096:biosynthesis; D009419:Nerve Tissue Proteins; D064231:Nestin; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects; D014212:Tretinoin / Q000494:pharmacology
D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; D064231:Nestin; D014212:Tretinoin