An evolutionary approach reveals a high protein-coding capacity of the human genome.
We developed a new evolutionary method for identifying exons from genomic sequences and found 19000 potential coding exons that are absent from all existing annotations of the human genome. Of these, 13700 satisfied very stringent criteria and can with confidence be considered as novel exons. Evidently, a large number of new human genes can be identified using evolutionary approaches.
Nekrutenko
Anton
A
Department of Ecology and Evolution, The University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA.
Chung
Wen Yu
WY
Li
Wen Hsiung
WH
D000818:Animals; D017124:Conserved Sequence; D019143:Evolution, Molecular; D005091:Exons; D015894:Genome, Human; D006801:Humans; D051379:Mice; D017422:Sequence Analysis, DNA / Q000379:methods*