Mycobacterium tuberculosis gene expression in macrophages.
This review provides a discussion on the current information about the response of Mycobacterium tuberculosis to the environment encountered in the macrophage. We focus on the types of genes shown to be upregulated when the pathogen grows in macrophages and discuss the possible roles of these genes in adaptation to the conditions in the eukaryotic cell, in the context of enhancing the survival of the pathogen during infection.
Dubnau
Eugenie
E
TB Center, Public Health Research Institute of the International Center of Public Health, 225 Warren Street, Newark, NJ 07103, USA.
Smith
Issar
I
D001426:Bacterial Proteins / Q000235:genetics; D002473:Cell Wall / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D007501:Iron / Q000378:metabolism; D008055:Lipids / Q000235:genetics; D008264:Macrophages / Q000382:microbiology*; D018448:Models, Immunological; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid
D001426:Bacterial Proteins; D008055:Lipids; D007501:Iron