[Difference in expression of VEGF, bFGF and their receptors between the young and postmenopausal women with breast cancer].
OBJECTIVE
To study the difference in the expression of VEGF, bFGF and their receptors between young and postmenopausal women with breast cancer.


METHODS
The expression of VEGF, FLK-1, bFGF and FLG in 40 young and 30 postmenopausal women with breast cancer was studied by immunohistochemical method (SABC), with its relation with axillary lymph node metastasis and the clinical and pathologic characteristics. The expression index between these two groups was compared.


RESULTS
The positive axillary lymph node rate and the mean expression of VEGF, bFGF in the young group were higher than postmenopausal group (P < 0.01 and P < 0.05), respectively. The mean expression of VEGF, bFGF, FLK-1 and FLG of axillary lymph node positive patients was higher than the negative ones both in young and postmenopausal women groups (P < 0.05 and P < 0.01). There was also a significant difference in VEGF, bFGF, FLK-1, FLG and MVC between the stage 0 - II and stage III - IV (P < 0.05 and P < 0.01) in both groups.


CONCLUSIONS
Breast cancer angiogenesis, characterized by the high expression of VEGF and bFGF, is directly correlated with the high tumor aggressiveness in the young women.
Yi
Wen-jun
WJ
Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Tang
Zhong-hua
ZH
Yang
Zhu-lin
ZL
Yu
Mei-ying
MY
Li
Yun-shan
YS
Chen
Gan-nong
GN
D000328:Adult; D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000032:analysis*; D000091344:Filaggrin Proteins; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008875:Middle Aged; D017698:Postmenopause; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000032:analysis*
C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D011960:Receptors, Estrogen; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; C496348:FGFR1 protein, human; D051496:Receptor, Fibroblast Growth Factor, Type 1; D040301:Vascular Endothelial Growth Factor Receptor-2