title: Short-term tests with a pilot sewage plant and biofilm reactors for the biological degradation of the pharmaceutical compounds clofibric acid, ibuprofen, and diclofenac.
abstract: The biodegradation of three active compounds of pharmaceuticals clofibric acid, ibuprofen, and diclofenac was investigated in short-term tests with a pilot sewage plant (PSP) and biofilm reactors (BFR, oxic and anoxic) as model systems for municipal sewage treatment. The PSP was characterized with respect to mixing behavior, the BFR with respect to biofilm content and sorption of the pharmaceutical compounds. The short-term experiments were carried out for 55 h in the PSP and for 48 h in the BFR. The concentration of the pharmaceuticals was in the microgram per liter range in presence of readily biodegradable substances in the milligram per liter range. Therefore, a too short time period and too low concentration to promote adaption of the microorganisms were applied. Under the operating conditions applied the biodegradation of the lipid lowering agent clofibric acid and the analgesic agents ibuprofen and diclofenac in the oxic BFR resembled that in the PSP. Clofibric acid and diclofenac were not eliminated and reached a level of approximately 95% of their initial concentration, whereas the concentration of ibuprofen was decreased to approximately 40% in the PSP and to approximately 35% in the oxic BFR. Both systems showed, therefore, an inherent ability for ibuprofen biodegradation. Elimination in the anoxic BFR resulted in a decrease of the concentration of all three substances to values between 60 and 80% of their initial concentration. In contrast to the PSP acetone revealed as inhibitor in the BFR. In both systems acetone was not degraded in the short-term tests.
authors.affiliation: Engler-Bunte-Institut, Water Chemistry, Universität Karlsruhe (TH), Engler-Bunte-Ring 1, D-76131 Karlsruhe, Germany. christian.zwiener@ciw.uni-karlsruhe.de
authors.forename: C
authors.initials: C
authors.lastname: Zwiener
authors.forename: F H
authors.initials: FH
authors.lastname: Frimmel
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000032:analysis / Q000378:metabolism*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000378:metabolism*; D018441:Biofilms; D019149:Bioreactors; D002995:Clofibric Acid / Q000032:analysis / Q000378:metabolism*; D004008:Diclofenac / Q000032:analysis / Q000378:metabolism*; D000960:Hypolipidemic Agents / Q000032:analysis / Q000378:metabolism*; D007052:Ibuprofen / Q000032:analysis / Q000378:metabolism*; D008962:Models, Theoretical; D012037:Refuse Disposal; D012722:Sewage; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000378:metabolism*; D018508:Water Purification / Q000379:methods*
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000960:Hypolipidemic Agents; D012722:Sewage; D014874:Water Pollutants, Chemical; D004008:Diclofenac; D002995:Clofibric Acid; D007052:Ibuprofen