title: Arterial wall thermography.
abstract: An atherosclerotic plaque is considered vulnerable when it is at higher risk of inducing acute cardiac events. The early detection and follow-up of the vulnerable plaque are crucial to prevent these events from happening. To date there are no proven techniques to detect such a plaque. Arterial wall thermography, tracing the heat signature of the activated macrophages, is a new and promising method in this direction. However, the difficulties of applying such a method in vivo should not be neglected. Current science proposes several potential thermographic methods. They can be generally categorized as noninvasive and invasive. Magnetic resonance thermometry (MRT) is the most important noninvasive method. It is novel, accurate, and reproducible, but is unfortunately hampered by resolution limitations due to the size and motion of the target vessels. The "infrared" and the "contact-sensor" are the most important invasive thermographic methods. Mainly due to the difficulties of infrared radiation in penetrating the flowing blood, the contact thermographic methods seem to be the most feasible at present. The superiority of thermal mapping of the arterial wall versus the localized temperature measurements is clear. The use of multiple thermal sensors arranged around the vessel's circumference and the application of motorized catheter pullback, not only ensure a large area of coverage, but also enable us to build thermal maps and vascular thermoanatomical reconstructions by using modern computer technology. It is expected that arterial thermography will undoubtedly initiate debate, mainly concerning the most appropriate therapy for the vulnerable plaque. Data collection and correct interpretation are expected to lead us into making wise decisions.
authors.affiliation: Cardiology Department, University Hospital Gasthuisberg, Leuven, Belgium. leo@otenet.gr
authors.forename: Leonidas
authors.initials: L
authors.lastname: Diamantopoulos
mesh_terms: D001158:Arteries / Q000473:pathology*; D001831:Body Temperature; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000503:physiopathology; D003328:Coronary Thrombosis / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D008264:Macrophages / Q000000981:diagnostic imaging; D011859:Radiography; D012422:Rupture, Spontaneous / Q000175:diagnosis / Q000503:physiopathology; D013817:Thermography