title: Radiation dosimetry results from a Phase II trial of ibritumomab tiuxetan (Zevalin) radioimmunotherapy for patients with non-Hodgkin's lymphoma and mild thrombocytopenia.
abstract: This was a 30-patient Phase II trial of reduced-dose (90)Y ibritumomab tiuxetan (Zevalin) RIT for patients with low-grade, follicular, or transformed B-cell NHL and mild thrombocytopenia. Patients were given an imaging dose of (111)In-labeled ibritumomab tiuxetan for dosimetry measurements. One week later, patients were administered a therapeutic dose of 0.3 mCi/kg (11 MBq/kg) (90)Y ibritumomab tiuxetan. Both (111)In- and (90)Y-labeled ibritumomab tiuxetan doses were preceded by an infusion of 250 mg/m(2) rituximab (Rituxan, MabThera) an unlabeled chimeric anti-CD20 antibody, to clear peripheral blood B cells and improve biodistribution of the radiolabeled antibody. For all 30 patients, normal organ and red marrow radiation absorbed doses were well below protocol-defined limits of 2000 cGy and 300 cGy, respectively. Median radiation absorbed doses were 48 cGy to red marrow (range: 6.5-95 cGy), 393 cGy to liver (range: 92-1581 cGy), 522 cGy to spleen (range: 165-1711 cGy), 162 cGy to lungs (41-295 cGy), and 14 cGy to kidneys (0.03-65 cGy). Though most correlative analyses were negative, certain analyses demonstrated a statistically significant correlation between the severity or duration of thrombocytopenia and pharmacokinetic or dosimetric parameters. These correlations were not consistent across the total patient population, and therefore, could not be exploited to predict hematologic toxicity.
authors.affiliation: Mayo Clinic, Rochester, MN 55905, USA. gwiseman@mayo.edu
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Wiseman
authors.forename: Bryan R
authors.initials: BR
authors.lastname: Leigh
authors.forename: William D
authors.initials: WD
authors.lastname: Erwin
authors.forename: Richard B
authors.initials: RB
authors.lastname: Sparks
authors.forename: Donald A
authors.initials: DA
authors.lastname: Podoloff
authors.forename: Russell J
authors.initials: RJ
authors.lastname: Schilder
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Bartlett
authors.forename: Stewart M
authors.initials: SM
authors.lastname: Spies
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Grillo-López
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Witzig
authors.forename: Christine A
authors.initials: CA
authors.lastname: White
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D018951:Antigens, CD20 / Q000276:immunology; D003131:Combined Modality Therapy; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D016499:Radioimmunotherapy / Q000379:methods*; D011874:Radiometry; D016879:Salvage Therapy; D013921:Thrombocytopenia / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D000911:Antibodies, Monoclonal; D018951:Antigens, CD20; D015021:Yttrium Radioisotopes; C422802:ibritumomab tiuxetan