title: [Combined MTX.5-FU.CDGP for the treatment of head and neck cancer].
abstract: Combination chemotherapy including 5-fluorouracil (5-FU) and nedaplatin (CDGP) with methotrexate (MTX) and leucovorin (LV) was administered for modulation in patients with head and neck cancer. We treated 19 patients with MTX.5-FU.CDGP consisting of 150 mg/body of MTX on day 1 followed by a 3-day continuous infusion of 5-FU at 3,500 mg/m2 and 17 injections of LV at 15 mg and infusion of CDGP at 100 mg/m2. Six patients had recurrent head and neck cancer, and 13 had newly diagnosed disease. Eleven of the new patients were concurrently treated with radiation therapy. Treatment-associated toxicity was significant, including mucositis and myelosuppression, but acceptable. Sixteen patients were eligible for evaluation of response. The overall complete response rate was 75.0% (12/16). Patients treated with radiotherapy had a 90.0% (9/10) overall complete response rate.
authors.affiliation: Dept. of Sensory and Motor Organs, Division of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Tottori University.
authors.forename: Takema
authors.initials: T
authors.lastname: Sakoda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Saitoh
authors.forename: Satoshi
authors.initials: S
authors.lastname: Seno
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ikeda
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Dake
authors.forename: Tadao
authors.initials: T
authors.lastname: Enomoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawano
authors.forename: Hiroya
authors.initials: H
authors.lastname: Kitano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D011859:Radiography; D018714:Radiotherapy, Adjuvant; D012074:Remission Induction; D016019:Survival Analysis
chemical_list: D009944:Organoplatinum Compounds; C053989:nedaplatin; D002955:Leucovorin; D005472:Fluorouracil; D008727:Methotrexate