Antimicrobial and antiproliferative activity of Peucedanum nebrodense (Guss.) Strohl.
Acetone extract of Peucedanum nebrodense (Guss.) Strohl., a rare endemic species from the Madonie mountains (Sicily), was tested in vitro for its antimicrobial activity against bacterial reference strains and antiproliferative activity against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) and L1210 (murine leukemia) cell lines. The acetone extract showed antiproliferative IC50 values in the range of 14-0.27 microg/ml.
Schillaci
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Dipartimento di Chimica e Tecnologie Farmaceutiche, University of Palermo, Via Archirafi 32, 90123, Palermo, Italy. dschill@unipa.it
Venturella
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Venuti
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Plescia
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D000096:Acetone; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D007939:Leukemia L1210; D051379:Mice; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D010936:Plant Extracts; D000096:Acetone