title: [Endoscopic biliary drainage in patients with pancreatic cancer].
abstract: Obstructive jaundice is a common clinical sign in patients with pancreatic cancer. 52% of all patients with a potentially resectable pancreatic cancer suffer from painless obstructive jaundice. There are no prospective studies showing a beneficial effect of preoperative drainage in patients with resectable pancreatic cancer. Morbidity (53%) and mortality (15%) in patients without preoperative biliary drainage are not significantly different from those who had endoscopic drainage preoperatively (morbidity 41%; mortality 15%). However, there are some logistic reasons for preoperative drainage, especially if surgery is delayed. In cases of nonresectable pancreatic cancer endoscopic drainage for palliation of obstructive jaundice is the method of choice. The decision between metallic and plastic stents for palliation is based on expected survival time and quality of life. Implantation of metal stents is the method of choice in patients with life expectancy exceeding six months. Scheduled three months exchange of plastic stents is recommended to avoid complications. After a six months interval about 70% of patients with scheduled exchange are without symptoms, compared to about 40% of patients who had exchange of plastic stents on demand. Scheduled three months exchange of plastic stents leeds to a patency rate of plastic stents comparable to those of metallic stents.
authors.affiliation: Klinik für Gastroenterologie, Hepatologie und Infektiologie, Otto-von-Guericke Universität Magdeburg. stefan.kahl@medizin.uni-magdeburg.de
authors.forename: S
authors.initials: S
authors.lastname: Kahl
authors.forename: S
authors.initials: S
authors.lastname: Zimmermann
authors.forename: M
authors.initials: M
authors.lastname: Pross
authors.forename: H-U
authors.initials: HU
authors.lastname: Schulz
authors.forename: P
authors.initials: P
authors.lastname: Malfertheiner
mesh_terms: D000368:Aged; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002779:Cholestasis / Q000209:etiology / Q000601:surgery*; D004322:Drainage / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D008017:Life Expectancy; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008670:Metals; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000401:mortality / Q000601:surgery; D010969:Plastics; D011300:Preoperative Care; D011446:Prospective Studies; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D015607:Stents; D013997:Time Factors
chemical_list: D008670:Metals; D010969:Plastics