Effect of Erysod (erythrocyte superoxide dismutase) on blood concentration of reactive oxygen species in patients with severe burns and burn shock.
The dynamics of blood concentrations of reactive oxygen species and LPO products in patients with thermal injuries of different severity was studied. Monitoring of these parameters by chemiluminescent and spectrophotometric techniques helps to predict the course of burn shock and prevent complications. Erysod (0.004% solution, 33-66 microg/min, daily dose 24-32 mg) added to antishock infusion therapy during the early periods after injury suppressed generation of free radicals (by 20% after 15 min and by 30-40% after 24 h), promoted normalization of their contents, and reduced damage to visceral organs during acute period of thermal injury.
Churilova
I V
IV
State Institute of Extrapure Biological Preparations, St. Petersburg. churilova@hpb.spb.ru
Zinov'ev
E V
EV
Paramonov
B A
BA
Drozdova
Yu I
YI
Sidel'nikov
V O
VO
Chebotarev
V Yu
VY
D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002056:Burns / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008163:Luminescent Measurements; D017382:Reactive Oxygen Species / Q000097:blood*; D012769:Shock / Q000097:blood* / Q000188:drug therapy* / Q000209:etiology; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*
D000975:Antioxidants; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase