Effects on axonal conduction of anti-ganglioside sera and sera from patients with Guillain-Barré syndrome.
The efficacy of plasma exchange as a therapy for Guillain-Barré syndrome (GBS) suggests that humoral factors might contribute to the axonal conduction block responsible for the major symptoms of the disease. To explore this possibility, we have applied sera to rat spinal roots in vitro while monitoring axonal conduction. Neither fresh sera from 12 patients with GBS or Miller-Fisher syndrome (MFS), nor serum from rabbits immunised with Campylobacter jejuni from patients with GBS, MFS or gastroenteritis were effective in causing acute conduction block, despite the presence of antibodies to gangliosides GD3, GM1, GQ1b and GT1a. Potential explanations are advanced.
Dilley
A
A
Neuroinflammation Research Group, Guy's, King's and St. Thomas' School of Medicine, King's College, SE1 1UL, London, UK.
Gregson
N A
NA
Hadden
R D M
RD
Smith
K J
KJ
D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood* / Q000494:pharmacology*; D001369:Axons / Q000187:drug effects / Q000276:immunology* / Q000473:pathology; D001798:Blood Proteins / Q000276:immunology / Q000494:pharmacology; D002169:Campylobacter Infections / Q000097:blood / Q000276:immunology; D005732:Gangliosides / Q000276:immunology*; D005759:Gastroenteritis / Q000097:blood / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000097:blood* / Q000276:immunology*; D006801:Humans; D019846:Miller Fisher Syndrome / Q000097:blood / Q000276:immunology; D009431:Neural Conduction / Q000187:drug effects / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D013126:Spinal Nerve Roots / Q000187:drug effects / Q000276:immunology / Q000473:pathology
D001323:Autoantibodies; D001798:Blood Proteins; D005732:Gangliosides