Systemic and discoid lupus erythematosus in HIV-infected patients treated with highly active antiretroviral therapy.
Although HIV infection is often associated with several rheumatic diseases, the coexistence of this retroviral infection and systemic lupus erythematosus (SLE) is extremely uncommon. Generally, HIV-related immunosuppression improves SLE symptoms, and antiretroviral therapy may lead to an autoimmune disease flare subsequent to the increase of circulating CD4+ cell number. Two HIV-infected female patients with SLE and discoid lupus erythematosus (DLE) diagnosed a few months after the highly active antiretroviral therapy initiation, are described. To our knowledge, this is the second case of DLE and the twenty-seventh case of SLE reported to date in association with HIV infection.
Calza
Leonardo
L
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S. Orsola Hospital, Italy. malinf@med.unibo.it
Manfredi
Roberto
R
Colangeli
Vincenzo
V
D'Antuono
Antonietta
A
Passarini
Beatrice
B
Chiodo
Francesco
F
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000150:complications* / Q000175:diagnosis; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis