title: Management of large hemispheric strokes in the neurological intensive care unit.
abstract: BACKGROUND
  Patients with large hemispheric strokes frequently develop neurologic deterioration secondary to cerebral edema. Despite supportive care in the intensive care unit and traditional forms of therapy for cerebral edema, they have a high morbidity and mortality. New forms of therapy are being investigated to improve outcome in these patients.
  
  
  RESULTS
  This article begins with a discussion of the clinical and radiologic features of large hemispheric strokes. The role of increased intracranial pressure in neurologic deterioration and the predictors of outcome in these patients are reviewed. The various therapeutic options for management of cerebral edema in these patients, including the role of osmotic therapy, hypothermia, and hemicraniectomy, are explored.
  
  
  CONCLUSIONS
  Neurologic deterioration in patients with large hemispheric strokes necessitates admission to the intensive care unit for management of the airway, blood pressure, and cerebral edema. New promising therapies, such as hemicraniectomy and hypothermia, need to be further evaluated to define their role in the management of these patients.
authors.affiliation: Neurology/Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. aiyagariv@neuro.wustl.edu
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Aiyagari
authors.forename: Michael N
authors.initials: MN
authors.lastname: Diringer