title: [Relationship between clinical and therapeutic variables and health-related quality of life in patients with hypertension. MINICHAL Study].
abstract: OBJECTIVE
  Our objective was to evaluate, through the health related quality of life (HRQoL) questionnaire MINICHAL, the influence of socio-demographic, clinical and therapeutic variables on health related quality of life of hypertensive patients.
  
  
  METHODS
  An observational, prospective and multi-center study was carried out in hypertensive patients who were either starting or undergoing a modification of antihypertensive treatment. A total of three visits was done: a baseline visit and two follow-up visits at one and six months. At all three visits, several socio-demographic, clinical and therapeutic variables were recorded and HRQoL was measured using the MINICHAL questionnaire, the Spanish version of the Psychological General Well-Being Index, and a single question about the change in general health status. The objective was to evaluate the impact of these variables on HRQoL.
  
  
  RESULTS
  736 patients with hypertension were evaluated. In the multivariate analysis, gender, number of concomitant diseases, degree of hypertension, organ damage and educational level were all variables displaying a relation with HRQoL. After 6 months of treatment intensification, an improvement of HRQoL was observed. Moreover, a positive correlation was observed between the degree of reduction of blood pressure (BP) and heart rate and HRQoL improvement, especially in the State of mind dimension.
  
  
  CONCLUSIONS
  In hypertension, a better BP control has a positive influence on HRQoL. As several clinical variables are negatively correlated with HRQoL, specific interventions are needed to correct modifiable factors.
authors.affiliation: Unidad de Hipertensión. Servicio de Medicina Interna. Hospital de la Santa Creu i Sant Pau. Barcelona. Spain. aroca@hsp.santpau.es
authors.forename: Alex
authors.initials: A
authors.lastname: Roca-Cusachs
authors.forename: Xavier
authors.initials: X
authors.lastname: Badia
authors.forename: Antoni
authors.initials: A
authors.lastname: Dalfó
authors.forename: Ginés
authors.initials: G
authors.lastname: Gascón
authors.forename: José
authors.initials: J
authors.lastname: Abellán
authors.forename: Raquel
authors.initials: R
authors.lastname: Lahoz
authors.forename: Cristina
authors.initials: C
authors.lastname: Varela
authors.forename: Olga
authors.initials: O
authors.lastname: Velasco
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D006973:Hypertension / Q000523:psychology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires