title: Assessment of antimicrobial activity of hydrophilic betaines in osmotically stressed bacteria.
abstract: A series of hydrophilic aromatic and semi-aromatic betaines related to trigonelline was synthesized and tested for antimicrobial activity. 4-Methylthiazolium betaine was the only one that showed significant antibacterial activity towards Escherichia coli under hyperosmotic conditions. None of the tested betaines showed any evidence of osmoprotection or urea protection.
authors.affiliation: Department of Nephrology, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand. BarbaraP@chhlth.govt.nz
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Peddie
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Wood
authors.forename: Michael
authors.initials: M
authors.lastname: Lever
authors.forename: D Alan R
authors.initials: DA
authors.lastname: Happer
authors.forename: Frederick
authors.initials: F
authors.lastname: de Zwart
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Chambers
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001622:Betaine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004285:Dogs; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests / Q000379:methods; D009994:Osmolar Concentration; D009997:Osmotic Pressure; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology*; D014508:Urea
chemical_list: D000470:Alkaloids; C009560:trigonelline; D001622:Betaine; D014508:Urea