Human leukocyte antigen distribution in Israeli patients with psoriatic arthritis.
OBJECTIVE
This study was designed to investigate the distribution of human leukocyte antigen (HLA) classes I and II in a group of Israeli Jewish patients with psoriatic arthritis (PsA) and identify HLA markers related to disease manifestation in PsA.


METHODS
Human leukocyte antigens class I and class II (both serologically and from oligotyping) were tested in a group of 50 consecutive patients with PsA, 32 with skin psoriasis (PSO), and 255 healthy persons. Data on age, gender, disease duration, and pattern of rheumatological manifestations-oligoarthritis, polyarthritis, spinal involvement, involvement of distal interphalangeal joints (DIPs), and enthesitis-were registered.


RESULTS
Human leukocyte antigens A3, B13, and B38 alleles were found to be significantly prevalent in PsA compared with PSO patients and healthy controls. HLA-B27 was found in only two out of 50 patients with PsA. Patients with PSO and PsA had significantly increased incidence of HLA-DRB0101 and -DRB0301, while the frequency of HLA-DRB0403 was significantly higher among patients with PsA of Ashkenazi origin. We found a statistically significant association between DIP involvement and the presence of HLA-A26 and -B38, while HLA-DRB0301 was related to spinal involvement.


CONCLUSIONS
Psoriatic arthritis in Israeli patients seems to be associated with the presence of HLA-A3, -B13, -B38, -DRB0101, and -DRB0301. HLA-B27 was not a marker of PsA in this cohort of patients, including patients with psoriatic spondyloarthropathy.
Elkayam
Ori
O
Department of Rheumatology, Sourasky Medical Center, Tel Aviv, Israel. oribe14@netvision.net.il
Segal
Refael
R
Caspi
Dan
D
D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000097:blood / Q000208:ethnology / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006680:HLA Antigens / Q000097:blood / Q000276:immunology*; D006801:Humans; D007557:Israel; D007585:Jews / Q000208:ethnology; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D006680:HLA Antigens