Lymphatic filariasis in Papua New Guinea: interdisciplinary research on a national health problem.
Bancroftian filariasis is a major public health problem in Papua New Guinea, where the level of transmission by the mosquito vector, human infection rates and clinical morbidity are among the highest in the world. Coordinated research efforts within the country, involving the disciplines of epidemiology, vector biology, immunology and genetics, have led to new insights into the ecology and pathogenesis of human lymphatic filariasis. Recent work using this knowledge base should be helpful in assessing local and global strategies aimed at eliminating Wuchereria bancrofti and in guiding research that will facilitate achievement of this goal.
Kazura
James W
JW
Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106, USA. jxk14@po.cwru.edu
Bockarie
Moses J
MJ
D000818:Animals; D000852:Anopheles / Q000145:classification; D004605:Elephantiasis, Filarial / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D007303:Insect Vectors / Q000145:classification; D010219:Papua New Guinea / Q000453:epidemiology; D011634:Public Health; D012106:Research / Q000458:organization & administration* / Q000639:trends; D012307:Risk Factors; D014958:Wuchereria bancrofti