title: Anogenital warts contributing to the risk of squamous intraepithelial lesions among HIV-positive women of São Paulo, Brazil.
abstract: Unsafe sexual practices may expose HIV-positive women to high-grade squamous intraepithelial lesions (SIL) and to infection with oncogenic human papillomavirus (HPV) types. A cross sectional study of 141 HIV-positive women was designed to evaluate risk factors for the development of cervico-vaginal SIL and HPV-DNA detection/typing. Uni- and multivariate forward stepwise analysis was used to determine the relationship between risk variables and HPV infection and between risk behaviour, HPV and HIV infection with development of SIL. Univariate analysis showed that HPV-DNA infection was related to previous and recurrent anogenital warts, male genital warts and cytological alteration. For final multivariate analysis, both HPV type (undetermined- and high-risk, OR=29.3 and 112.0, respectively) were statistically associated (P=0.019) with high-grade cervico-vaginal SIL. The presence of anogenital warts as well as high- and undetermined-risk HPV infection may alert to cyto/histopathological alterations. These results point out the importance of the use of barrier methods and routine early genitoscopy/treatment for HIV-infected partners.
authors.affiliation: Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirao Preto, University of São Paulo, Brazil. epigin@uol.com.br
authors.forename: Maria Alice G
authors.initials: MA
authors.lastname: Gonçalves
authors.forename: Marcelo N
authors.initials: MN
authors.lastname: Burattini
authors.forename: Eduardo A
authors.initials: EA
authors.lastname: Donadi
authors.forename: Eduardo
authors.initials: E
authors.lastname: Massad
mesh_terms: D000328:Adult; D000367:Age Factors; D001938:Brazil / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D003218:Condylomata Acuminata / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D017533:Marital Status; D008875:Middle Aged; D015233:Models, Statistical; D015999:Multivariate Analysis; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology; D012008:Recurrence; D012307:Risk Factors; D012725:Sexual Behavior; D014412:Tumor Virus Infections / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology*; D014625:Vaginal Neoplasms / Q000453:epidemiology*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology*
chemical_list: D004279:DNA, Viral