Of mice and men: phylogenetic footprinting aids the discovery of regulatory elements.
Phylogenetic footprinting is an approach to finding functionally important sequences in the genome that relies on detecting their high degrees of conservation across different species. A new study shows how much it improves the prediction of gene-regulatory elements in the human genome.
Zhang
Zhaolei
Z
Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520-8114, USA.
Gerstein
Mark
M
D000818:Animals; D018983:DNA Footprinting / Q000639:trends*; D005809:Genes, Regulator / Q000235:genetics*; D006801:Humans; D051379:Mice; D010802:Phylogeny