Microbial metabolites of harman alkaloids.
Several microorganisms showed the ability to transform the harman alkaloids, harmaline (1), harmalol (2) and harman (5). Harmaline (1) and harmalol (2) were converted by Rhodotorula rubra ATCC 20129 into the tryptamines, 2-acetyl-3-(2-acetamidoethyl)-7-methoxyindole (3) and 2-acetyl-3-(2-acetamidoethyl)-7-hydroxyindole (4), respectively. Harman (5) was biotransformed by Cunninghamella echinulata NRRL 3655 into 6-hydroxyharman (6) and harman-2-oxide (7).
Herath
Wimal
W
National Center of Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, MS 38677, USA.
Mikell
Julie Rakel
JR
Ferreira
Daneel
D
Khan
Ikhlas Ahmad
IA
D001711:Biotransformation; D020093:Cunninghamella / Q000378:metabolism*; D006246:Harmaline / Q000031:analogs & derivatives* / Q000378:metabolism; D006247:Harmine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012248:Rhodotorula / Q000378:metabolism*
C007904:harmalol; D006247:Harmine; C005010:harman; D006246:Harmaline