title: Significant role of middle hepatic vein in remnant liver regeneration of right-lobe living donors.
abstract: For adult patients with end-stage liver disease, living-donor liver transplantation (LDLT) of right-lobe grafts with or without the middle hepatic vein (MHV) has been increasingly used in recent years. We investigated the role of the MHV in donor remnant liver regeneration after right-lobe LDLT, which has not been described in previous studies. A total of eight living donors were included in this study of right-lobe LDLT. Four donors underwent right lobectomy (without MHV), and the remaining four underwent extended right lobectomy (with MHV). Regeneration of the donor remnant liver was assessed by volumetric computed tomography studies before and 90 days after LDLT. Comparison between the right-lobe and extended right-lobe donors did not show a clear-cut difference in the net increase of remnant liver volume at 3 months. However, the mean volume increase of the medial segment at the 90th postoperative day was 7% in the extended right-lobe donors and 61% in the right-lobe donors, showing a lower value in the remnant livers without MHV. The MHV plays a specific role in remnant liver regeneration of right-lobe living donors. We expect that this knowledge will contribute to securing a margin of safety in right-lobe LDLT.
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kobe University, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kido
authors.forename: Yonson
authors.initials: Y
authors.lastname: Ku
authors.forename: Takumi
authors.initials: T
authors.lastname: Fukumoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tominaga
authors.forename: Takeshi
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ogata
authors.forename: Masanori
authors.initials: M
authors.lastname: Takenaga
authors.forename: Masanori
authors.initials: M
authors.lastname: Takahashi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Shinya
authors.initials: S
authors.lastname: Tahara
authors.forename: Koichi
authors.initials: K
authors.lastname: Tanaka
authors.forename: Shin
authors.initials: S
authors.lastname: Hwang
authors.forename: Sunggyu
authors.initials: S
authors.lastname: Lee
mesh_terms: D000328:Adult; D005260:Female; D006503:Hepatic Veins / Q000502:physiology*; D006801:Humans; D008115:Liver Regeneration; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged