Effect of fluoridated dentifrice and acidulated phosphate fluoride application on early artificial carious lesions.
OBJECTIVE
To evaluate the effect of a combination of fluoride dentifrice and acidulated phosphate fluoride (APF) on enamel with incipient caries lesions.


METHODS
Bovine dental enamel blocks with artificial caries lesions were divided into four treatment groups and submitted to a pH-cycling model: (1) Placebo non-fluoridated dentifrice (PD); (2) Fluoridated dentifrice (FD), 1,100 ppm F; (3) APF (12,300 ppm F, pH 3.5) + PD; 4) APF+FD. APF was applied to enamel blocks of groups APF+PD and APF+FD before the pH-cycling regimen and all of them were exposed to dentifrice during the cycling.


RESULTS
The results showed that 61-81% of the fluoride previously deposited in enamel by APF was released to the media during the pH-cycling. The final concentration of fluoride in enamel in the group APF+PD was lower than that before the cycling (P < 0.05), but in the group APF+FD the reduction was not significant (P> 0.05). FD treatment was significantly more efficient than PD in rehardening the enamel surface and increasing the hardness of the caries lesions. APF+PD treatment was not more efficient than PD in increasing enamel hardness and an additive effect of APF+FD was not observed.
Paes Leme
Adriana Franco
AF
Department of Physiological Sciences, Faculty of Dentistry of Piracicaba, State University of Campinas, SP, Brazil.
Tabchoury
Cinthia Pereira Machado
CP
Zero
Domenick Thomas
DT
Cury
Jaime Aparecido
JA
D000149:Acidulated Phosphate Fluoride / Q000627:therapeutic use; D000704:Analysis of Variance; D000818:Animals; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002417:Cattle; D003731:Dental Caries / Q000188:drug therapy*; D003743:Dental Enamel / Q000378:metabolism; D003747:Dental Enamel Solubility; D003802:Dentifrices / Q000737:chemistry; D005459:Fluorides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006244:Hardness; D012463:Saliva / Q000737:chemistry; D018709:Statistics, Nonparametric; D014089:Tooth Remineralization
D002327:Cariostatic Agents; D003802:Dentifrices; D000149:Acidulated Phosphate Fluoride; D005459:Fluorides