Photochemical and photophysical properties of indoprofen.
The photophysical properties and photochemistry of indoprofen (INP) have been investigated. Absorption and emission spectroscopies in phosphate buffer, ethanol and ether show that INP photophysics is dominated by a singlet-singlet transition of pipi* character. INP fluoresces at room temperature, with a quantum yield approximately 0.04. Flash photolysis experiments together with the lack of phosphorescence at room temperature point to a very weak intersystem crossing. The photoreactivity of INP is centered on the propionic acid chain and gives rise to photoproducts similar to those obtained with other arylpropionic acids (ethyl, hydroxyethyl and acetyl derivatives). Thus, irradiation of INP in aqueous buffer results in photodecarboxylation and leads mainly to oxidative compounds whose proportions increase with increasing oxygen concentration. These data suggest a photoreactivity occurring from the excited singlet state.
Lhiaubet-Vallet
V
V
Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique, UMR 5623 au CNRS, Université Paul Sabatier, Toulouse, France.
Trzcionka
J
J
Encinas
S
S
Miranda
M A
MA
Chouini-Lalanne
N
N
D016861:Cyclooxygenase Inhibitors / Q000737:chemistry* / Q000528:radiation effects; D004583:Electrons; D007216:Indoprofen / Q000737:chemistry* / Q000528:radiation effects; D008027:Light; D010777:Photochemistry; D010782:Photolysis; D013053:Spectrophotometry; D014466:Ultraviolet Rays
D016861:Cyclooxygenase Inhibitors; D007216:Indoprofen