title: [The influence of continuous renal replacement therapy on the plasma levels of endotoxin and cytokines in severely burned patients with sepsis].
abstract: OBJECTIVE
  To investigate the influence of continuous renal replacement therapy (CRRT) on the plasma levels of endotoxin and cytokines in severely burned patients with sepsis.
  
  
  METHODS
  Ten burn patients who received CRRT and another 10 without CRRT were investigated in terms of the changes in their plasma concentrations of endotoxin and some cytokines (TNFalpha, IL-1beta, IL-6, IL-8).
  
  
  RESULTS
  The plasma concentrations of endotoxin and all the cytokines (TNFalpha, IL-1beta, IL-6, IL-8) after CRRT treatment were significantly lower than those before the treatment (P < 0.01), and the plasma levels of the above factors at all the time points after CRRT treatment than those in patients were evidently lower by routine treatment (P < 0.05 - 0.01).
  
  
  CONCLUSIONS
  CRRT treatment could effectively lower the plasma levels of endotoxin and some cytokines (TNFalpha, IL-1beta, IL-6, IL-8).
authors.affiliation: Institute of Burn Research, Southwestern Hospital, The Third Military Medical University, Institute of Organ Transplantation Research of Chongqing City. Chongqing, 400038. P.R. China.
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Li
authors.forename: Yi-Zhi
authors.initials: YZ
authors.lastname: Peng
mesh_terms: D002056:Burns / Q000097:blood* / Q000150:complications; D004731:Endotoxins / Q000097:blood*; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D017582:Renal Replacement Therapy; D018805:Sepsis / Q000097:blood* / Q000209:etiology / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D004731:Endotoxins; D053583:Interleukin-1beta; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha