title: Spontaneous remission of a massive CNS inflammation with eosinophilic infiltrate.
abstract: We report a case of spontaneous remission of a massive CNS lesion with eosinophilic infiltrate. This 69-year-old man had eosinophilia without any systemic disorder or laboratory evidence of the most common causes of hypereosinophilia. MRI of the brain suggested an infiltrating neoplasm, but histological examination of a needle biopsy specimen failed to show evidence of a neoplasm. Instead, the tissue demonstrated rarefaction and gliosis with striking perivascular and parenchymal infiltrates of eosinophils. The MRI abnormality and eosinophilia disappeared spontaneously. We speculate that eosinophil-derived neurotoxins might have been the cause of the transient CNS disorder observed in this patient.
authors.affiliation: Department of Neurology, Kitano Hospital, Osaka.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Tamaru
authors.forename: Mayumi
authors.initials: M
authors.lastname: Nakashita
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Ito
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Okumura
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Terukuni
authors.initials: T
authors.lastname: Imai
mesh_terms: D000368:Aged; D004660:Encephalitis / Q000175:diagnosis* / Q000209:etiology*; D004802:Eosinophilia / Q000150:complications* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012075:Remission, Spontaneous