title: Effect of sustained release isosorbide dinitrate (EV151) in dogs with experimentally-induced mitral insufficiency.
abstract: To investigate the hemodynamic effects on seven anesthetized dogs with experimentally-induced mitral insufficiency, isosorbide dinitrate (ISDN) in sustained release form (EV151) was administered at different dosages (0, 2, 8 and 16 mg/kg). The drug administration resulted in altered pulmonary arterial wedge pressure (preload), and cardiac output and total systemic resistance (afterload). Arterial pressure increased in the control group and in animals receiving 2 mg/kg, but decreased in animals 1-2 hr after receiving 8 and 16 mg/kg dosages. Cardiac output increased in animals receiving 2, 8 and 16 mg/kg dosages, with concomitant decreases in total systemic resistance. ISDN caused mild vasodilation at 2 mg/kg and severe vasodilation at 8 and 16 mg/kg. Future experiments on non-anesthetized dogs may be of benefit.
authors.affiliation: Animal Clinical Research Foundation, Kurayoshi-shi, Tottori, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nagasawa
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Takashima
authors.forename: Yuko
authors.initials: Y
authors.lastname: Masuda
authors.forename: Tomonori
authors.initials: T
authors.lastname: Kataoka
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kuno
authors.forename: Naoki
authors.initials: N
authors.lastname: Kaba
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Yamane
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000009:adverse effects / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects*; D007548:Isosorbide Dinitrate / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D008944:Mitral Valve Insufficiency / Q000188:drug therapy* / Q000503:physiopathology / Q000662:veterinary*; D014664:Vasodilation / Q000187:drug effects
chemical_list: D003692:Delayed-Action Preparations; D007548:Isosorbide Dinitrate