Interleukin-10 promoter polymorphisms in patients with Guillain-Barré syndrome.
Interleukin-10 (IL-10) may have both pro- and anti-inflammatory effects in Guillain-Barré syndrome (GBS). The distribution of polymorphisms in the IL-10 gene (-1082 (G/A), -819 (T/C) and -592 (A/C)) was analysed to determine whether they could influence disease susceptibility or clinical course in GBS. The -592 CC and -819 CC genotypes associated with increased IL-10 response were more frequent in the GBS patients than in the controls (P=0.027), but the polymorphisms did not influence the clinical course of the disease.
Myhr
K-M
KM
Department of Neurology, Multiple Sclerosis National Competence Centre, Haukeland Hospital, University of Bergen, N-5021, Bergen, Norway. kjmy@haukeland.no
Vågnes
K S
KS
Marøy
T H
TH
Aarseth
J H
JH
Nyland
H I
HI
Vedeler
C A
CA
D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D020275:Guillain-Barre Syndrome / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics* / Q000276:immunology; D008297:Male; D017933:Peripheral Nervous System / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012189:Retrospective Studies
D016753:Interleukin-10