title: [Expression of chemokine in the labial glands of patients with Sjogren's syndrome].
abstract: OBJECTIVE
  To investigate the expression of chemokine RANTES (regulated upon activation, normal T cell expressed and secreted) and macrophage inflammatory protein 1alpha (MIP-1alpha) in the labial glands of patients with Sjogren's syndrome (SS) and discuss their involvement in SS etiopathology.
  
  
  METHODS
  Immunohistochemistry was used to examine the expression of RANTES and MIP-1alpha in the specimens of labial gland of 14 cases of primary SS, 7 cases of secondary SS (sSS), and 8 cases of controls, including maxillofacial injury and lip cyst.
  
  
  RESULTS
  The expression rate of RANTES was 86% (12/14) in the pSS group and 71% (10/14) in the sSS group, and was 0 in the control group (P < 0.01). The expression rate of MIP-1alpha was 86% (5/7) in the pSS group, 71% (5/7) in the sSS group, and 25% (2/8) in the control group (P > 0.05). The RANTES and MIP-1alpha were expressed in the cytoplasm of ductal epithelium and part of infiltrated lymphocytes. The positive expression of RANTES was more evident than that of MIP-1alpha.
  
  
  CONCLUSIONS
  RANTES and MIP-1alpha may attract the circulating lymphocytes towards inflammation site of labial gland so as play a crucial role in the pathogenesis of SS etiopathology.
authors.affiliation: Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medicine, Beijing 100730, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Zhen-gang
authors.initials: ZG
authors.lastname: Wang
authors.forename: Fu-lin
authors.initials: FL
authors.lastname: Tang
mesh_terms: D000328:Adult; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5 / Q000032:analysis / Q000096:biosynthesis*; D004727:Endothelium / Q000737:chemistry; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008046:Lip; D019402:Macrophage Inflammatory Proteins / Q000032:analysis / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D012470:Salivary Glands, Minor / Q000378:metabolism*; D012859:Sjogren's Syndrome / Q000378:metabolism*
chemical_list: D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D019402:Macrophage Inflammatory Proteins