Vancomycin-intermediate Staphylococcus aureus with phenotypic susceptibility to methicillin in a patient with recurrent bacteremia.
Vancomycin-intermediate Staphylococcus aureus (VISA) are an emerging problem. We observed a statistically significant inverse relationship in the MICs of vancomycin and oxacillin in S. aureus isolates from a patient undergoing hemodialysis who received 26 weeks of treatment with vancomycin during November 1999 through April 2000. All isolates were mecA positive and were indistinguishable by pulsed-field gel electrophoresis. The evolving susceptibility patterns of this strain highlight the challenges of detecting and treating VISA infections.
Naimi
Timothy S
TS
Acute Disease Epidemiology Section and Division of Public Health Laboratories, Minnesota Department of Health, Minneapolis, MN, USA. tbn7@cdc.gov
Anderson
Daniel
D
O'Boyle
Carol
C
Boxrud
David J
DJ
Johnson
Susan K
SK
Tenover
Fred C
FC
Lynfield
Ruth
R
D016470:Bacteremia / Q000188:drug therapy*; D001426:Bacterial Proteins; D005075:Biological Evolution; D002352:Carrier Proteins / Q000235:genetics; D006602:Hexosyltransferases; D006801:Humans; D008297:Male; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance / Q000235:genetics; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D002267:Muramoylpentapeptide Carboxypeptidase / Q000235:genetics; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000502:physiology; D014640:Vancomycin / Q000627:therapeutic use*; D020713:Vancomycin Resistance / Q000235:genetics
D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D014640:Vancomycin; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D008712:Methicillin