title: Graft-versus-tumor effect in a patient with advanced neuroblastoma who received HLA haplo-identical bone marrow transplantation.
abstract: A 5-year-old boy received CD34-positive HLA haplo-identical bone marrow transplantation from his father as treatment for refractory advanced neuroblastoma. He had residual disease in the para-aortic lymph nodes and multiple bones after the transplant. However, all of his residual disease had disappeared completely 3 years later. He developed grade I acute graft-versus-host disease (GVHD) but had no symptoms of chronic GVHD or any other complications. This case demonstrates the possibility of a graft-versus-tumor effect against neuroblastoma by HLA-mismatched allogeneic hematopoietic stem cell transplantation.
authors.affiliation: Department of Pediatrics, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: A
authors.initials: A
authors.lastname: Yoneda
authors.forename: M
authors.initials: M
authors.lastname: Nishikawa
authors.forename: M
authors.initials: M
authors.lastname: Nakayama
authors.forename: K
authors.initials: K
authors.lastname: Yumura-Yagi
authors.forename: N
authors.initials: N
authors.lastname: Sakata
authors.forename: M
authors.initials: M
authors.lastname: Yasui
authors.forename: T
authors.initials: T
authors.lastname: Okamura
authors.forename: K
authors.initials: K
authors.lastname: Kawa
mesh_terms: D016026:Bone Marrow Transplantation / Q000276:immunology*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D002675:Child, Preschool; D018572:Disease-Free Survival; D006086:Graft vs Host Disease; D020350:Graft vs Tumor Effect / Q000276:immunology*; D006239:Haplotypes; D006648:Histocompatibility; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D018365:Neoplasm, Residual / Q000175:diagnosis; D009447:Neuroblastoma / Q000473:pathology / Q000628:therapy*; D011877:Radionuclide Imaging; D014185:Transplantation, Isogeneic