A complex of antioxidant vitamins effectively inhibits free-radical oxidation of LDL phospholipids in blood plasma and membrane structures of the liver and myocardium.
Antioxidant effect of a complex preparation including antioxidant vitamins C, E, provitamin A and selenium was studied on the model of Cu(2+)-initiated free-radical oxidation of LDL isolated from human blood plasma. The antioxidant effect of combined administration of alpha-tocopherol+ascorbic acid and alpha-tocopherol+beta-carotene is far more pronounced that the antioxidant effect of individual components of these cocktails. Moreover, in the model system the combined action of all antioxidant components completely inhibited free-radical oxidation of LDL. A 30-day course of peroral administration of antioxidant vitamin cocktail and selenium to rats pronouncedly enhanced the antioxidant potential of liver and completely suppressed free-radical processes in the myocardium. It is suggested that preparations containing antioxidant vitamins and selenium can be perspective for prevention and complex therapy of atherosclerosis.
Konovalova
G G
GG
Laboratory of Biochemistry of Free-Radical Processes, A. L. Myasnikov Institute of Cardiology, Russian Cardiology Research-and-Production Center, Russian Ministry of Health, Moscow.
Lisina
M O
MO
Tikhaze
A K
AK
Lankin
V Z
VZ
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D010084:Oxidation-Reduction; D010949:Plasma / Q000378:metabolism*; D051381:Rats; D012643:Selenium / Q000378:metabolism; D014815:Vitamins / Q000008:administration & dosage / Q000378:metabolism*; D019207:beta Carotene / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D008077:Lipoproteins, LDL; D014815:Vitamins; D019207:beta Carotene; D012643:Selenium