Diffusion-weighted MR imaging in neonatal nonketotic hyperglycinemia.
To our knowledge, we are the first to report the diffusion-weighted MR imaging findings in a 15-day-old neonate with nonketotic hyperglycinemia. We found bilaterally symmetrical lesions of restricted diffusion in the dorsal brain stem, cerebral peduncles, and posterior limbs of the internal capsule, which were more conspicuous and extensive on diffusion-weighted MR images than on T2-weighted images. These lesions are in the myelinated tracts of the neonate and are compatible with the expected sites of abnormality in vacuolating myelinopathy.
Khong
Pek-Lan
PL
Department of Diagnostic Radiology, Queen Mary Hospital, University of Hong Kong, 102 Pokfulam Road, Hong Kong, ROC.
Lam
Barbara C C
BC
Chung
Brian H Y
BH
Wong
Ka-Yin
KY
Ooi
Gaik-Cheng
GC
D001921:Brain / Q000473:pathology*; D001928:Brain Diseases, Metabolic / Q000175:diagnosis* / Q000235:genetics; D001933:Brain Stem / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D020158:Hyperglycinemia, Nonketotic / Q000175:diagnosis* / Q000235:genetics; D007231:Infant, Newborn; D020772:Internal Capsule / Q000473:pathology; D008636:Mesencephalon / Q000473:pathology; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D012680:Sensitivity and Specificity