Recognition of HLA-A*0248 in a Chinese donor.
HLA-A*0248, a rare allele originally found in an individual of Filipino background, was detected in a Chinese donor. We confirmed the novel sequence and analysed its serological reaction pattern. The exon 2 sequence of A*0248 was apparently generated in a gene conversion event with an A2 gene, receiving a sequence segment comprising codons 56 to 74 from an A*24 donor gene. Serological typing showed a clear-cut A2 reaction pattern, indicating that the three amino acid positions 62, 65 and 74, are probably not a critical part of the A2 epitope. Our typing experience also demonstrated that different typing technologies often complement each other in fine HLA typing.
Yang
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KL
Tzu Chi Immunogenetics Centre and Cord Blood Bank, Buddhist Compassion Relief Tzu Chi Foundation, 707, Section 3, Chung Yang Road, Hualien, Taiwan 970. edward@tzuchi.com.tw
Gao
X
X
Lin
P Y
PY
D019943:Amino Acid Substitution; D002681:China; D003429:Cross Reactions; D015234:HLA-A Antigens / Q000235:genetics* / Q000276:immunology*; D006239:Haplotypes / Q000235:genetics / Q000276:immunology; D006801:Humans; D012698:Serologic Tests
D015234:HLA-A Antigens