title: Association of high coronary heart disease risk status with circulating oxidized LDL in the well-functioning elderly: findings from the Health, Aging, and Body Composition study.
abstract: OBJECTIVE
  Although circulating oxidized LDL (oxLDL) is elevated in persons with coronary heart disease (CHD), whether oxLDL is elevated in persons with high CHD risk before any events is unknown. Therefore, we studied the association between high, predicted CHD risk and oxLDL in the Health ABC cohort.
  
  
  RESULTS
  This cohort included 385 persons with CHD and 1183 persons at high risk; the latter were all persons with CHD risk equivalents: noncoronary forms of clinical atherosclerotic disease, diabetes, and a 10-year risk for CHD >20% by Framingham scoring. The remaining 1535 participants were at low risk. Levels of oxLDL were 1.18+/-0.61 mg/dL for low-risk persons, 1.50+/-0.81 mg/dL for high-risk persons without diagnosed CHD, and 1.32+/-0.83 mg/dL for persons with CHD (P<0.001). The odds ratio for high CHD risk in the highest quintile of oxLDL, compared with the lowest quintile and after adjusting for age, sex, race, LDL cholesterol, smoking status, and C-reactive protein, was 2.79 (P<0.001).
  
  
  CONCLUSIONS
  The odds ratio for elevated oxLDL among persons with high CHD risk before any CHD events was higher than that among persons with established CHD. A likely explanation is that once CHD is diagnosed, individuals are frequently treated with a statin, which is associated with lowering of LDL cholesterol and oxLDL levels.
authors.affiliation: Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit, Leuven, Belgium. paul.holvoet@med.kuleuven.ac.be
authors.forename: Paul
authors.initials: P
authors.lastname: Holvoet
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Harris
authors.forename: Russell P
authors.initials: RP
authors.lastname: Tracy
authors.forename: Peter
authors.initials: P
authors.lastname: Verhamme
authors.forename: Anne B
authors.initials: AB
authors.lastname: Newman
authors.forename: Susan M
authors.initials: SM
authors.lastname: Rubin
authors.forename: Eleanor M
authors.initials: EM
authors.lastname: Simonsick
authors.forename: Lisa H
authors.initials: LH
authors.lastname: Colbert
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Kritchevsky
mesh_terms: D000368:Aged; D001823:Body Composition; D008078:Cholesterol, LDL / Q000378:metabolism*; D015897:Comorbidity; D003327:Coronary Disease / Q000453:epidemiology* / Q000378:metabolism*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology / Q000378:metabolism; D006949:Hyperlipidemias / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D010084:Oxidation-Reduction; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology; D013714:Tennessee / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D014280:Triglycerides