[Directly observed treatment of latent tuberculosis infection: comparative study of two isoniazid regimens].
BACKGROUND
To compare compliance with two isoniazid regimens in drug users with latent tuberculosis infection. METHODS.


METHODS
clinical trial. Group 1: isoniazid 300 mg once daily (16 patients); Group 2: isoniazid 900 mg/twice weekly (21).


METHODS
compliance, toxicity and efficacy.


RESULTS
Group 1 vs. Group 2: continuation in program 81/82% (p 5 NS), compliance full doses 43.7/66.6% (p 5 0.1), median percentage of days not taking isoniazid: 1.8 (0.2-4.3) vs. 0 (0-1.7) (p 5 0.06).


CONCLUSIONS
Compliance was high in both therapeutic arms. The twice-weekly isoniazid regimen favored compliance, but differences were not significant.
Portilla
Joaquín
J
Unidad de Enfermedades Infecciosas. Hospital General Universitario de Alicante. Spain.
Jordá
Pilar
P
Esteban
Javier
J
Sánchez-Payá
José
J
Merino
Esperanza
E
Boix
Vicente
V
D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002353:Carrier State / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008691:Methadone / Q000627:therapeutic use; D008875:Middle Aged; D010349:Patient Compliance; D019966:Substance-Related Disorders / Q000150:complications / Q000534:rehabilitation; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy*
D000995:Antitubercular Agents; D008691:Methadone; D007538:Isoniazid