title: Effects of transcranial magnetic stimulation on the H reflex and F wave in the hand muscles.
abstract: OBJECTIVE
  In 14 healthy subjects, we studied the effects of transcranial magnetic stimulation (TMS) on the excitability of spinal motoneurons in the abductor pollicis brevis muscle (ABP), by testing the F wave and H reflex.
  
  
  METHODS
  TMS pulses were delivered with the subjects at rest and at various motor threshold (Mth) intensities. Electrical stimuli were delivered to the median nerve at the wrist at two different intensities. High-intensity pulse was used to evoke an F wave and low-intensity paired pulse to evoke an H reflex in the ABP muscle. The effects of TMS were studied using a conditioning-test paradigm. The tests F wave and H reflex were conditioned by TMS (120% Mth) at various interstimulus intervals (ISIs) (30-100ms) and intensities (90-200% Mth).
  
  
  RESULTS
  At 30ms but not at ISIs from 40 to 100ms, conditioning TMS (120% Mth) significantly increased the F-wave area. At the 30ms ISI, conditioning TMS at 120% Mth intensity significantly increased the F-wave area whereas higher intensities (140-180% Mth) did not. At 200% Mth intensity, the F-wave area decreased significantly. At 30 and 40ms ISIs, conditioning TMS at 120% Mth significantly reduced the H-reflex area. At 50-100ms ISIs, the H-reflex area almost matched the control value. At the 30ms ISI, conditioning TMS at >or=100% Mth intensity significantly decreased the H-reflex area.
  
  
  CONCLUSIONS
  In conclusion, our findings suggest that the distinct changes in the TMS-conditioned F wave and H reflex reflect changing excitability in the motoneuronal populations activated by the cortical input.
authors.affiliation: Dipartimento Scienze Neurologiche, Università di Roma La Sapienza, Viale Università, 30, 00185, Rome, Italy. maurizio.inghilleri@uniforma1.it
authors.forename: M
authors.initials: M
authors.lastname: Inghilleri
authors.forename: C
authors.initials: C
authors.lastname: Lorenzano
authors.forename: A
authors.initials: A
authors.lastname: Conte
authors.forename: V
authors.initials: V
authors.lastname: Frasca
authors.forename: M
authors.initials: M
authors.lastname: Manfredi
authors.forename: A
authors.initials: A
authors.lastname: Berardelli
mesh_terms: D000328:Adult; D004558:Electric Stimulation / Q000379:methods*; D004576:Electromyography / Q000379:methods; D019054:Evoked Potentials, Motor; D005260:Female; D006181:H-Reflex / Q000502:physiology*; D006225:Hand / Q000502:physiology*; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D009431:Neural Conduction; D013997:Time Factors; D050781:Transcranial Magnetic Stimulation