title: A system-approach method for the adjustment of time-varying continuous drug infusion in individual patients: a simulation study.
abstract: The aim of this simulation study was to present a system-approach method for adjustment of continuous drug infusions at time-varying rates, aimed at achieving and then maintaining required drug concentration-time profiles in patients. The method presented can be used for safe and cost-effective individualization of drug dosing by computer-controlled infusion pumps. Utilization of this method is exemplified by simulation experiments, aimed at adjusting continuous infusions of Factor VIII (FVIII) at time-varying rates, which would theoretically yield required concentration-time profiles of FVIII in hemophilia A patients over several days.
authors.affiliation: Institute of Experimental Pharmacology, Slovak Academy of Sciences, 841 04 Bratislava, Slovak Republic.
authors.forename: Mária
authors.initials: M
authors.lastname: Durisová
authors.forename: Ladislav
authors.initials: L
authors.lastname: Dedík
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D005169:Factor VIII / Q000008:administration & dosage / Q000493:pharmacokinetics; D006467:Hemophilia A / Q000097:blood; D006801:Humans; D007262:Infusions, Intravenous; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010599:Pharmacokinetics
chemical_list: D004364:Pharmaceutical Preparations; D005169:Factor VIII