Arterial thrombosis induced by IVIg and its treatment with tPA.
IV immunoglobulin therapy can lead to vascular events through increased serum viscosity and possibly other mechanisms. The authors describe the successful use of tissue plasminogen activator in three of four patients who developed cerebral and peripheral arterial thrombosis after treatment with IV immunoglobulin.
Okuda
Darin
D
Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA. ksivakumar@chw.edu
Flaster
Murray
M
Frey
James
J
Sivakumar
Kumaraswamy
K
D001158:Arteries; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects*; D020767:Intracranial Thrombosis / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000188:drug therapy / Q000209:etiology; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
D016756:Immunoglobulins, Intravenous; D010959:Tissue Plasminogen Activator