ATP synthesis driven by proton transport in F1F0-ATP synthase.
Topical questions in ATP synthase research are: (1) how do protons cause subunit rotation and how does rotation generate ATP synthesis from ADP+Pi? (2) How does hydrolysis of ATP generate subunit rotation and how does rotation bring about uphill transport of protons? The finding that ATP synthase is not just an enzyme but rather a unique nanomotor is attracting a diverse group of researchers keen to find answers. Here we review the most recent work on rapidly developing areas within the field and present proposals for enzymatic and mechanoenzymatic mechanisms.
Weber
Joachim
J
Department of Biochemistry and Biophysics, Box 712, University of Rochester Medical Center, Rochester, NY 14642, USA.
Senior
Alan E
AE
D000255:Adenosine Triphosphate / Q000096:biosynthesis*; D000818:Animals; D002384:Catalysis; D020134:Catalytic Domain; D006868:Hydrolysis; D017136:Ion Transport; D008958:Models, Molecular; D009038:Motion; D006180:Proton-Translocating ATPases / Q000737:chemistry* / Q000378:metabolism*; D011522:Protons
D011522:Protons; D000255:Adenosine Triphosphate; D006180:Proton-Translocating ATPases