title: An overview of the success and failure of surgical therapy: standards against which the outcome of endoscopic therapy is measured.
abstract: Medical therapy for reflux disease has evolved from frequent antacid use to once daily proton pump inhibitor therapy. Despite the efficacy of these agents in healing erosive esophagitis, there are several short-comings with medical therapy including incomplete symptom relief, the need for continuous maintenance therapy, and cost. Endoscopic and laparoscopic treatments for reflux disease are appealing because they could reduce or eliminate the need for chronic maintenance therapy with medications. While there is evidence of high quality on the efficacy of medical therapy from randomized controlled trials, data on endoscopic procedures and surgery is more limited. This article summarizes the needed studies and the standards against which these procedures should be measured.
authors.affiliation: University of Wisconsin Medical School, Aurora Sinai Medical Center, 945 North 12th Street, Room 4040, Milwaukee, WI 53233, USA. nvakil@facstaff.wisc.edu
authors.forename: Nimish
authors.initials: N
authors.lastname: Vakil
authors.forename: Christino
authors.initials: C
authors.lastname: Canga
mesh_terms: D002986:Clinical Trials as Topic; D016145:Endoscopy, Digestive System / Q000379:methods / Q000592:standards*; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000601:surgery*; D006801:Humans; D017211:Treatment Failure