Urinary tract infections, VUR, and autosomal dominant polycystic kidney disease.
This case series of 16 patients with autosomal dominant polycystic kidney disease (ADPKD) describes 4 girls who presented with a urinary tract infection (UTI). Radiological evaluation revealed that each of these patients had vesicoureteral reflux (VUR). The frequency of VUR was significantly higher in the patients with ADPKD compared with otherwise healthy age-matched children who underwent testing after a UTI (100% versus 15%, P<0.002). These findings suggest VUR is an associated somatic anomaly in children with ADPKD that may contribute to the occurrence of UTI in this patient population.
Koslowe
Oren
O
Department of Pediatrics, Division of Nephrology, Schneider Children's Hospital of the North Shore- Long Island Jewish Health System, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York, USA.
Frank
Rachel
R
Gauthier
Bernard
B
Vergara
Marcela
M
Trachtman
Howard
H
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications* / Q000000981:diagnostic imaging; D011859:Radiography; D014552:Urinary Tract Infections / Q000150:complications* / Q000000981:diagnostic imaging; D014718:Vesico-Ureteral Reflux / Q000150:complications* / Q000000981:diagnostic imaging