[Effect of chemotherapy on cytosol proteins of ovarian tumors].
Cytosol proteins of malignant ovarian tumors were studied with one- and two-dimensional gel electrophoresis, prior to and after effective chemotherapy with cisplatin and taxotere. Effective chemotherapy caused the bands and spots of 29, 36 and 50-55 kDa to fade significantly or disappear completely. It is suggested that protein 36 kDa is the proliferating nuclear cell antigen while one of the proteins 50-55 kDa--betatubulin. These proteins may serve as additional markers of ovarian tumor sensitivity to chemotherapy.
Blumenberg
A G
AG
N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences.
Mavletova
D A
DA
Deberer
L Iu
LIu
Gorbachëva
L B
LB
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology; D003600:Cytosol / Q000187:drug effects* / Q000378:metabolism; D000077143:Docetaxel; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D006801:Humans; D009363:Neoplasm Proteins / Q000187:drug effects* / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000494:pharmacology; D043823:Taxoids
D009363:Neoplasm Proteins; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel; D002945:Cisplatin