Migration and T-lymphocyte effector function.
The development of immunity depends upon the capacity of responding T cells to become mobilized from lymphoid tissues where they are primed to sites of antigen exposure, wherever they occur in the body. Activation-induced alterations in the ability of T cells to migrate signify a fundamental change in biological function. Considerable attention is now focused on identifying mechanisms that regulate the migration and persistence of T cells that disseminate to non-lymphoid compartments as effector cells, and those that are retained in the lymphoid compartment. There are many unanswered questions about the developmental relationships and roles in protective immunity of antigen-experienced T cells that partition in different tissues.
Bradley
Linda M
LM
Division of Immunology, The Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA. lbradley@skcc.org
D002465:Cell Movement; D007156:Immunologic Memory; D018448:Models, Immunological; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism