Comparative 3-week clinical tooth-shade evaluation of a novel liquid whitening gel containing 18% carbamide peroxide and a commercially available whitening dentifrice.
A randomized, controlled, examiner-blind, parallel-group clinical trial was performed to compare the tooth-whitening benefits of a novel, nontray, "paint-on" liquid gel containing 18% carbamide peroxide (Colgate Simply White Clear Whitening Gel) to those of a commercially available whitening dentifrice. Efficacy was measured by using Vita shade scores obtained at baseline and after 2 and 3 weeks of product use. Eighty subjects were first balanced according to gender, age, and shade scores into two groups. Half were then randomly assigned to either alpha 3-week routine of tooth-brushing (using a nonwhitening dentifrice) and twice-daily 18% carbamide peroxide gel application or a 3-week routine of twice-daily brushing with the commercially available whitening dentifrice. At the completion of the study, the results showed that subjects' teeth in the liquid whitening gel-treated group exhibited a statistically significant (P < .05) 4.12 mean tooth-shade improvement compared to baseline and exhibited a mean score that was 3.7 units higher than the corresponding mean score of the group assigned to use the whitening dentifrice (statistically significant, P < .05). It can therefore be concluded that the combined use of Colgate Simply White Clear Whitening Gel immediately after brushing with a regular toothpaste is clinically superior at whitening teeth than solely using a clinically proven, commercially available whitening dentifrice.
Nathoo
Salim
S
Oral Health Clinical Services, Colgate-Palmolive Technology Center, Piscataway, New Jersey, USA.
Giniger
Martin
M
Proskin
Howard M
HM
Stewart
Bernal
B
Robinson
Richard
R
Collins
Michael
M
DeVizio
William
W
Petrone
Margaret
M
Volpe
Anthony R
AR
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000077463:Carbamide Peroxide; D045424:Complex Mixtures; D003742:Dental Devices, Home Care; D003802:Dentifrices / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000627:therapeutic use; D010545:Peroxides / Q000627:therapeutic use; D016037:Single-Blind Method; D014073:Tooth Bleaching; D014075:Tooth Discoloration / Q000188:drug therapy; D016896:Treatment Outcome; D014508:Urea / Q000031:analogs & derivatives / Q000627:therapeutic use
C475021:Colgate Simply White Clear Whitening Gel; D045424:Complex Mixtures; D003802:Dentifrices; D004338:Drug Combinations; D016877:Oxidants; D010545:Peroxides; D000077463:Carbamide Peroxide; D014508:Urea