title: Bromocriptine augmentation therapy in a patient with Cotard's syndrome.
abstract: A 72-year-old female with bipolar I disorder developed Cotard's syndrome, i.e., various delusions of negation accompanied by severe depressive symptoms. She responded neither to the combination of antipsychotic drug and antidepressant nor to the lithium augmentation therapy. However, the delusions and depressive symptoms improved dramatically after the addition of bromocriptine 2.5-5 mg/day to the combination of clomipramine and lithium. This report suggests that bromocriptine augmentation therapy might be effective at least for some patients with Cotard's syndrome in mood disorders.
authors.affiliation: Department of Neuropsychiatry, Yamagata University School of Medicine, 990-9585, Yamagata, Japan. otani@med.id.yamagata-u.ac.jp
authors.forename: Shuko
authors.initials: S
authors.lastname: Kondo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hayashi
authors.forename: Takuya
authors.initials: T
authors.lastname: Eguchi
authors.forename: Takanobu
authors.initials: T
authors.lastname: Oyama
authors.forename: Tadashi
authors.initials: T
authors.lastname: Wada
authors.forename: Koichi
authors.initials: K
authors.lastname: Otani
mesh_terms: D000368:Aged; D001714:Bipolar Disorder / Q000150:complications* / Q000188:drug therapy*; D001971:Bromocriptine / Q000008:administration & dosage / Q000494:pharmacology*; D003702:Delusions / Q000188:drug therapy* / Q000209:etiology; D003863:Depression / Q000188:drug therapy* / Q000209:etiology; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D018491:Dopamine Agonists; D001971:Bromocriptine