title: Lack of association between pro-inflammatory genotypes of the interleukin-1 (IL-1B -31 C/+ and IL-1RN *2/*2) and gastric cancer/duodenal ulcer in Korean population.
abstract: IL-1beta is a pro-inflammatory cytokine with multiple biological effects and is a potent inhibitor of gastric acid secretion, and IL-1RN has been shown to be associated with enhanced IL-1beta production in vitro. Recently, it was reported that the pro-inflammatory genotypes, IL-1B -31 C/+ and IL-1RN *2/*2, were associated with an increased risk of gastric cancer in a Caucasian population. We tested the association between the polymorphisms and 190 gastric cancer, 117 duodenal ulcer, and 172 healthy subjects as controls in the Korean population. The allele frequency of IL-1B -31 C was more prevalent in Korean (51%) than in Caucasian (30%), while the frequency of IL-1RN *2 allele was less in Korean (6%) than in Caucasian (27%). Using the IL-1B TT genotype as a reference group, the CC genotype was not associated with an increased risk of gastric cancer or duodenal ulcer in the Korean population (odds ratios (OR)=0.90, 95% confidence interval (CI)=0.50-1.64; OR=0.72, 95% CI=0.36-1.46, respectively). Similarly, IL-1RN*2 was not a risk genotype for either gastric cancer or duodenal ulcer. No association was recognized on the haplotype analysis of the two genes, either. Our results did not support the previous report that IL-1B -31 C/IL-1RN*2 polymorphisms were associated with an increased risk of gastric cancer. The lack of association with duodenal ulcer also suggested that the polymorphisms were not directly related to the acid-secreting capability.
authors.affiliation: Asan Institute for Life Sciences, University of Ulsan College of Medicine, 388-1 Poongnap-Dong, Songpa-Gu, Seoul 138-736, South Korea.
authors.forename: Seong-Gene
authors.initials: SG
authors.lastname: Lee
authors.forename: Byungsik
authors.initials: B
authors.lastname: Kim
authors.forename: Wonyong
authors.initials: W
authors.lastname: Choi
authors.forename: Inchul
authors.initials: I
authors.lastname: Lee
authors.forename: Jaewon
authors.initials: J
authors.lastname: Choi
authors.forename: Kyuyoung
authors.initials: K
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D003627:Data Interpretation, Statistical; D004381:Duodenal Ulcer / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D007375:Interleukin-1 / Q000235:genetics*; D007723:Korea; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D007375:Interleukin-1