title: In vitro trypanocidal activity of triterpenes from miconia species.
abstract: The bioassay-guided fractionation of methylene chloride extracts of Miconia fallax DC. and Miconia stenostachya DC. led to the isolation of five triterpene acids. The triterpenes ursolic acid, oleanolic acid and gypsogenic acid were active against blood trypomastigote forms of Trypanosoma cruzi. In contrast, the acetyl and methyl ester derivatives were not found to potentiate the trypanocidal activity. These results suggest the importance of the polar groups for activity.
authors.forename: Wilson Roberto
authors.initials: WR
authors.lastname: Cunha
authors.forename: Camila
authors.initials: C
authors.lastname: Martins
authors.forename: Daniele
authors.initials: D
authors.lastname: da Silva Ferreira
authors.forename: Antonio Eduardo Miller
authors.initials: AE
authors.lastname: Crotti
authors.forename: Norberto Peporine
authors.initials: NP
authors.lastname: Lopes
authors.forename: Sérgio
authors.initials: S
authors.lastname: Albuquerque
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy; D006801:Humans; D035322:Melastomataceae; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D014315:Triterpenes; D014344:Trypanocidal Agents