Complementing thymidylate synthase.
The structure of thymidylate synthase complementing protein with substrates dUMP and FAD, presented in this issue of Structure, sheds light on a fascinating new catalytic mechanism, suggests a strategy for the design of new antimicrobial compounds, and highlights the promise of proteomics in medicine.
Montfort
William R
WR
D003856:Deoxyuracil Nucleotides / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D005182:Flavin-Adenine Dinucleotide / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D013940:Thymidylate Synthase / Q000737:chemistry* / Q000378:metabolism
D003856:Deoxyuracil Nucleotides; D005182:Flavin-Adenine Dinucleotide; C007267:2'-deoxyuridylic acid; D013940:Thymidylate Synthase