title: Effectiveness of influenza vaccination of children with recurrent respiratory tract infections in reducing respiratory-related morbidity within the households.
abstract: To evaluate the effectiveness of influenza vaccination in reducing respiratory-related morbidity among children with recurrent respiratory tract infections (RRTIs) and their household contacts, 127 children aged 6 months-9 years (78 males; median age, 3.7 years) with a history of RRTIs (>/=6 episodes per year if aged >/=3 years; >/=8 episodes per year if aged <3 years) were randomized to receive the intranasal virosomal influenza vaccine (n=64 with 176 household contacts) or a control placebo (n=63 with 173 household contacts). During influenza season, the vaccinated children had fewer respiratory infections, febrile respiratory illnesses, prescribed antibiotics and antipyretics, and missed school days than the controls, and similar benefits and a reduction in the loss of parental work were observed among their household contacts. This study shows that the benefits of influenza vaccination extend to children with RRTIs and their family members and encourages to recommend its use in such children.
authors.affiliation: Department of Pediatric I, University of Milan, Via Commenda 9, 20122, Milan, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Esposito
authors.forename: Paola
authors.initials: P
authors.lastname: Marchisio
authors.forename: Roberta
authors.initials: R
authors.lastname: Cavagna
authors.forename: Stefania
authors.initials: S
authors.lastname: Gironi
authors.forename: Samantha
authors.initials: S
authors.lastname: Bosis
authors.forename: Lara
authors.initials: L
authors.lastname: Lambertini
authors.forename: Roberta
authors.initials: R
authors.lastname: Droghetti
authors.forename: Nicola
authors.initials: N
authors.lastname: Principi
mesh_terms: D000281:Administration, Intranasal; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D007558:Italy; D008297:Male; D011446:Prospective Studies; D012008:Recurrence; D012140:Respiratory Tract Diseases / Q000453:epidemiology* / Q000517:prevention & control*; D012141:Respiratory Tract Infections / Q000150:complications*; D014611:Vaccination / Q000009:adverse effects
chemical_list: D007252:Influenza Vaccines