title: Glutamate-dependent stabilization of presynaptic terminals.
abstract: Dissecting the mechanisms underlying synapse formation and elimination is fundamental to understand how the nervous system is constructed and subsequently modified. Two studies by Tashiro et al. and by Hashimoto and Kano in this issue of Neuron provide new insights into the roles of neurotransmitter glutamate release in regulating the motility of hippocampal mossy fiber filopodia and synaptic competition among climbing fibers.
authors.affiliation: Molecular Neurobiology Program, Department of Physiology and Neuroscience, Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
authors.forename: Wen-Biao
authors.initials: WB
authors.lastname: Gan
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism*; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D019599:Mossy Fibers, Hippocampal / Q000254:growth & development* / Q000378:metabolism / Q000648:ultrastructure; D009473:Neuronal Plasticity / Q000502:physiology; D011554:Pseudopodia / Q000378:metabolism* / Q000648:ultrastructure; D018092:Kainic Acid Receptors / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D018698:Glutamic Acid; D018092:Kainic Acid Receptors