title: An efficient route to chiral alpha- and beta-hydroxyalkanephosphonates.
abstract: Enzymatic kinetic resolution of alpha- and beta-hydroxyphosphonates in combination with ruthenium-catalyzed alcohol isomerization led to a successful dynamic kinetic resolution. A variety of racemic hydroxyphosphonates were efficiently transformed to the corresponding enantiomerically pure acetates (ee up to 99% and yield up to 87%).
authors.affiliation: Arrhenius Laboratory, Department of Organic Chemistry, Stockholm University, SE-10691 Stockholm, Sweden. pamies@organ.su.se
authors.forename: Oscar
authors.initials: O
authors.lastname: Pàmies
authors.forename: Jan-E
authors.initials: JE
authors.lastname: Bäckvall