The dinB operon and spontaneous mutation in Escherichia coli.
Apparently conflicting data regarding the role of SOS-inducible, error-prone DNA polymerase IV (DinB) in spontaneous mutation are resolved by the finding that mutation is reduced by a polar allele with which dinB and neighboring yafN are deleted but not by two nonpolar dinB alleles. We demonstrate the existence of a dinB operon that contains four genes, dinB-yafN-yafO-yafP. The results imply a role for yafN, yafO, and/or yafP in spontaneous mutation.
McKenzie
Gregory J
GJ
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030-3411, USA.
Magner
Daniel B
DB
Lee
Peter L
PL
Rosenberg
Susan M
SM
D000483:Alleles; D001426:Bacterial Proteins / Q000235:genetics*; D019951:DNA Polymerase beta; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D009154:Mutation; D009876:Operon; D013014:SOS Response, Genetics
D001426:Bacterial Proteins; C094399:DinB protein, E coli; D029968:Escherichia coli Proteins; D019951:DNA Polymerase beta