title: Review article: indications for anti-reflux surgery in gastro-oesophageal reflux disease.
abstract: Gastro-oesophageal reflux disease (GERD) is a complex multifactorial disorder whose treatment is based on knowledge of its pathophysiology, natural history and evolution. Recently the relationship between the severest degrees of cardial incontinence and hiatus hernia has been emphasized, which causes the impairment of the mechanical properties of the gastro-oesophageal barrier and of oesophageal acid clearing. Among different types of hiatus hernia, those characterized by the permanent axial orad migration of the oesophago-gastric (EG) junction (nonreducible hiatus hernia) are correlated with severe GERD. Barium swallow may adequately differentiate hiatal insufficiency, concentric hiatus hernia and short oesophagus which are the steps of migration across or above the diaphragm. When associated with panmural oesophagitis and fibrosis of the oesophageal wall, these conditions may be the cause of recurrence of hiatus hernia and reflux after laparoscopic standard anti-reflux surgical procedures; in the presence of nonreducibility of the EG junction below the diaphragm without tension, dedicated surgical procedures are necessary. It is currently agreed that surgical therapy is indicated for patients affected by severe GERD who are not compliant with long-term medical therapy, require high dosages of drugs and are too young for lifetime medical treatment. While the existence of severe GERD correlated with an irreversible anatomical disorder represents an elective indication for surgery, warrants further investigation. Accurate identification of the functional and anatomical abnormalities underlying GERD is mandatory in order to decide whether medical or surgical therapy should be implemented, and to tailor the surgical technique, laparoscopic or open, to each patient.
authors.affiliation: Department of Surgery, Center for the Study & Therapy of Diseases of the Oesophagus (Surgical Section), University of Bologna, Bologna, Italy. mattioli@med.unibo.it
authors.forename: S
authors.initials: S
authors.lastname: Mattioli
authors.forename: M L
authors.initials: ML
authors.lastname: Lugaresi
authors.forename: M
authors.initials: M
authors.lastname: Pierluigi
authors.forename: M P
authors.initials: MP
authors.lastname: Di Simone
authors.forename: F
authors.initials: F
authors.lastname: D'Ovidio
mesh_terms: D005764:Gastroesophageal Reflux / Q000209:etiology / Q000601:surgery*; D006551:Hernia, Hiatal / Q000150:complications* / Q000601:surgery; D006801:Humans