title: Near adult heights after growth hormone treatment in patients with idiopathic short stature or idiopathic growth hormone deficiency.
abstract: OBJECTIVE
  Determination of near adult height (NAH) after recombinant human growth hormone (rhGH) therapy in patients with idiopathic short stature (ISS, maximum stimulated growth hormone [MSGH] > 10 ng/ml) or idiopathic growth hormone deficiency (IGHD, MSGH < or = 10 ng/ml) enrolled in the National Cooperative Growth Study Substudy 2.
  
  
  METHODS
  Female NAH was defined as height at age 18 or age 14 plus Tanner stage 4; male NAH was defined as height at age 20 or age 16 plus Tanner stage 4 or 5.
  
  
  RESULTS
  Both groups had similar enrollment heights: IGHD -2.7 +/- 0.7 versus ISS -2.8 +/- 0.6 (mean height standard deviation score [SDS] +/- SD). After rhGH treatment, there were no significant differences in NAH between the IGHD and ISS groups (-1.4 +/- 1.0 versus -1.6 +/- 1.0). Enrollment height SDS and MSGH value were significant predictors of delta height for the children with IGHD but not for the children with ISS (R2 = 0.45 IGHD versus R2 = 0.22 ISS).
  
  
  CONCLUSIONS
  We conclude that MSGH values should not be used as the primary criterion for rhGH therapy.
authors.affiliation: University of Arkansas for Medical Sciences, Little Rock, AR, USA. frindikpaul@uams.edu
authors.forename: J Paul
authors.initials: JP
authors.lastname: Frindik
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Kemp
authors.forename: J J
authors.initials: JJ
authors.lastname: Hunold
mesh_terms: D000293:Adolescent; D001827:Body Height / Q000187:drug effects*; D002648:Child; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology; D019382:Human Growth Hormone / Q000096:biosynthesis / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D019382:Human Growth Hormone