1,3-dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis.
An antiangiogenic purine analog, 1,3-dimethylisoguaninium (1), was isolated from the ethanol (EtOH) extract of the Okinawan sponge Amphimedon paraviridis. The structure was elucidated on the basis of its spectral properties and X-ray crystallographic analysis. Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner.
Jeong
Sei-Joon
SJ
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Inagaki
Masanori
M
Higuchi
Ryuichi
R
Miyamoto
Tomofumi
T
Ono
Mayumi
M
Kuwano
Michihiko
M
Van Soest
Rob W M
RW
D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D018360:Crystallography, X-Ray; D042783:Endothelial Cells / Q000187:drug effects*; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*
C107720:1,3-dimethylisoguanine; D020533:Angiogenesis Inhibitors; D006147:Guanine; D005346:Fibroblast Growth Factors