title: Bioactive crude plant seed extracts from the NCAUR oilseed repository.
abstract: Over four-hundred crude extracts from 202 plant species distributed among 131 plant families were evaluated for their bioactivity against brine shrimp (Artemia salina). Activity was determined for both the organic (CH2Cl2:MeOH) and aqueous extracts against A. salina in a 96 well-plate assay. Of the greater than four-hundred extracts tested, 21 organic and 6 aqueous extracts demonstrated potent cytotoxic activity (LC50 = < 100 microg/ml). Three of these organic extracts (Crateva religiosa, Diospyros dichrophylla, and Olax subscorpioidea) were chosen for chemical investigations due to their high activity and a lack of prior investigations. Chemical analysis of these extracts resulted in the isolation of oleanolic acid (1) and 4-epi-hederagenin (2) from C. religiosa, isodiospyrin (3) from D. dichrophylla, and santalbic acid (4) from O. subscorpioidea.
authors.affiliation: U.S. Department of Agriculture, Agricultural Research Service, National Center for Agricultural Utilization Research, Peoria, Illinois, USA. c.cantrell@hauser.com
authors.forename: C L
authors.initials: CL
authors.lastname: Cantrell
authors.forename: M A
authors.initials: MA
authors.lastname: Berhow
authors.forename: B S
authors.initials: BS
authors.lastname: Phillips
authors.forename: S M
authors.initials: SM
authors.lastname: Duval
authors.forename: D
authors.initials: D
authors.lastname: Weisleder
authors.forename: S F
authors.initials: SF
authors.lastname: Vaughn
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D031483:Capparaceae; D029788:Diospyros; D007928:Lethal Dose 50; D031656:Olacaceae; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D012639:Seeds
chemical_list: D010936:Plant Extracts