Combined near-infrared spectroscopy and multifrequency bio-impedance investigation of skin alterations in diabetes patients based on multivariate analyses.
A group of 34 diabetic men, with different degrees of diabetes complications, including skin changes, were studied by near-infrared (NIR) spectroscopy and total body multi-frequency bio-impedance analyses (MFBIA-body). Skin reflectance spectra were measured with a fibre-optic probe in four locations (sites): hand, arm, leg and foot. As control subjects, a group of 23 healthy males were also measured. A combined multivariate analysis of the two types of spectrum was performed. It was concluded that the NIR method has the potential to detect diabetes-related skin conditions and also that the combination of the two techniques provides a higher potential for classification and discrimination of the skin conditions, with correct classification increasing from 63% to 85%.
Nyström
J
J
Department of Chemistry, Umeå University, Umeå, Sweden.
Lindholm-Sethson
B
B
Stenberg
L
L
Ollmar
S
S
Eriksson
J W
JW
Geladi
P
P
D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000503:physiopathology*; D017097:Electric Impedance; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012867:Skin / Q000503:physiopathology*; D019265:Spectroscopy, Near-Infrared / Q000379:methods