title: Antibodies to neuronal targets in neurological and psychiatric diseases.
abstract: The role of antibodies to specific neuronal and muscle ion channels in the etiology of neuromuscular transmission disorders is now well accepted. In addition, maternal antibodies can cross the placenta and cause neonatal disease or even alter the development of the infant, raising the possibility that some neurodevelopmental conditions could be caused by maternal antibodies. Voltage-gated ion channels are expressed in the brain as well as at the neuromuscular junction, and in recent years it has become clear that antibodies to some central nervous system (CNS) channels can be associated with CNS disease. This review highlights features of these conditions, preliminary investigations into neurodevelopmental disorders, and areas for further study.
authors.affiliation: Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.
authors.forename: Angela
authors.initials: A
authors.lastname: Vincent
authors.forename: Paola
authors.initials: P
authors.lastname: Dalton
authors.forename: Linda
authors.initials: L
authors.lastname: Clover
authors.forename: Jackie
authors.initials: J
authors.lastname: Palace
authors.forename: Bethan
authors.initials: B
authors.lastname: Lang
mesh_terms: D000906:Antibodies; D001176:Arthrogryposis / Q000276:immunology; D001321:Autistic Disorder / Q000276:immunology; D002493:Central Nervous System Diseases / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D001523:Mental Disorders / Q000276:immunology*; D009422:Nervous System Diseases / Q000276:immunology*; D009469:Neuromuscular Junction / Q000276:immunology / Q000502:physiology; D009474:Neurons / Q000276:immunology*; D011247:Pregnancy; D011950:Receptors, Cholinergic / Q000502:physiology
chemical_list: D000906:Antibodies; D011950:Receptors, Cholinergic