title: Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene.
abstract: MicroRNAs (miRNAs) are an abundant class of RNAs that are approximately 21-25 nucleotides (nt) long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA interference, RNAi) depending on the degree of complementarity with their targets. Here we show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele.
authors.affiliation: LBME, Centre National de la Recherche Scientifique, UMR 5099, IFR 109, Université P. Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Seitz
authors.forename: Neil
authors.initials: N
authors.lastname: Youngson
authors.forename: Shau-Ping
authors.initials: SP
authors.lastname: Lin
authors.forename: Simone
authors.initials: S
authors.lastname: Dalbert
authors.forename: Martina
authors.initials: M
authors.lastname: Paulsen
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bachellerie
authors.forename: Anne C
authors.initials: AC
authors.lastname: Ferguson-Smith
authors.forename: Jérôme
authors.initials: J
authors.lastname: Cavaillé
mesh_terms: D000818:Animals; D001483:Base Sequence; D002875:Chromosomes / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D008969:Molecular Sequence Data; D016372:RNA, Antisense / Q000235:genetics*; D022661:RNA, Untranslated; D018626:Retroelements / Q000235:genetics*
chemical_list: D008565:Membrane Proteins; D035683:MicroRNAs; D016372:RNA, Antisense; D022661:RNA, Untranslated; D018626:Retroelements