title: Diffusion dynamics, moments, and distribution of first-passage time on the protein-folding energy landscape, with applications to single molecules.
abstract: We study the dynamics of protein folding via statistical energy-landscape theory. In particular, we concentrate on the local-connectivity case with the folding progress described by the fraction of native conformations. We found that the first passage-time (FPT) distribution undergoes a dynamic transition at a temperature below which the FPT distribution develops a power-law tail, a signature of the intermittent nonexponential kinetic phenomena for the folding dynamics. Possible applications to single-molecule dynamics experiments are discussed.
authors.affiliation: Department of Physics, State University of New York at Stony Brook, 11794, USA.
authors.forename: Chi-Lun
authors.initials: CL
authors.lastname: Lee
authors.forename: Chien-Ting
authors.initials: CT
authors.lastname: Lin
authors.forename: George
authors.initials: G
authors.lastname: Stell
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
mesh_terms: D007700:Kinetics; D015233:Models, Statistical; D016011:Normal Distribution; D011487:Protein Conformation; D017510:Protein Folding; D013696:Temperature; D013997:Time Factors