Quantitative EEG effects of topiramate.
OBJECTIVE
The study is to invesigate the effect of topiramate (TPM) on EEG by means of quantitative pharmacoelectroencephalography (QPEEG).


METHODS
One dose of TPM was administrated to epileptics and healthy adults. The EEG samples were obtained prior to and at regular intervals within the 24 hours following the administration of TPM. The EEG activity was processed with power spectral analysis.


RESULTS
The power of slow wave, alpha 1 bands and total power increased after the administration of TPM, the power or slow wave in both occipital areas, and the total power of all scalp areas also increased. The percent of power increased at the theta band and alpha 1 band (healthy adults) or delta band, theta band (patients).


CONCLUSIONS
TPM can change the EEG background activity. These changes are different from other antiepileptic drugs.
Wang
W W
WW
Department of Neurology, The First Hospital, Peking University, 8 Xi Shi Ku Street, Beijing 100034, China.
Li
J C
JC
Wu
X
X
D000328:Adult; D000927:Anticonvulsants / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects*; D004827:Epilepsy / Q000503:physiopathology; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose