Regulation by phosphorylation. Yet another twist in the WASP story.
Cell migration and other complex cellular processes involve a variety of signaling molecules and require the integration of multiple signals into a coherent cytoskeletal response. Two papers in the May issue of Molecular Cell now demonstrate that phosphorylation plays a critical role in WASP function as a regulator of Arp2/3-mediated actin polymerization.
Caron
Emmanuelle
E
Centre for Molecular Microbiology and Infection and Department of Biological Sciences, The Flowers Building, Armstrong Road, Imperial College London, SW7 2AZ, London, United Kingdom.
D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins / Q000378:metabolism; D001704:Biopolymers / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010766:Phosphorylation; D011487:Protein Conformation; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction; D014923:Wiskott-Aldrich Syndrome / Q000235:genetics; D051316:Wiskott-Aldrich Syndrome Protein
C495926:ACTR2 protein, human; C495928:ACTR3 protein, human; D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins; D001704:Biopolymers; D003598:Cytoskeletal Proteins; D011506:Proteins; C495767:WAS protein, human; D051316:Wiskott-Aldrich Syndrome Protein