[Interleukin 1 signal transduction].
In the human body, several factors play immunological roles. The molecular mechanisms of functions of these factors have been investigated extensively in the past. Interleukin 1 (IL-1) is a secreted protein and performs a central part in inflammatory responses. IL-1 binds to cell surface specific receptors and activates transcription factors through cytoplasmic mediators such as Myeloid differentiation factor 88 (MyD88), IL-1 receptor-associated kinase (IRAK) and TNF receptor-associated factor 6 (TRAF6). These are responsible for the induction of target genes, which are able to orchestrate or suppress the immune response. This review summarizes the available information to date on the signal transduction of IL-1.
Yoshida
Yasuhiro
Y
Department of Immunology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Yamashita
Uki
U
D048868:Adaptor Proteins, Signal Transducing; D000943:Antigens, Differentiation / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007375:Interleukin-1 / Q000276:immunology / Q000502:physiology*; D053594:Myeloid Differentiation Factor 88; D016328:NF-kappa B / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism; D017472:Receptors, Interleukin-1 / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D048029:TNF Receptor-Associated Factor 6
D048868:Adaptor Proteins, Signal Transducing; D000943:Antigens, Differentiation; D007375:Interleukin-1; C507779:MYD88 protein, human; D053594:Myeloid Differentiation Factor 88; D016328:NF-kappa B; D011506:Proteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D017472:Receptors, Interleukin-1; D048029:TNF Receptor-Associated Factor 6