title: Volumetric evidence of a left laterality effect in epileptic psychosis.
abstract: We investigated anatomic alterations and lateralization effect in the mesial temporal lobe structures (amygdala and hippocampus) in epileptic psychosis MRI volumetric measurements. Patients with epileptic psychosis and normal controls were studied. Left hippocampus values were significantly smaller for patients (P<0.001). Hippocampal ratio was significantly greater for patients (P<0.01). Group (patients x normal) was the only factor explaining the statistically significant variation of left hippocampus and hippocampal ratio (P<0.001 and P<0.05). Twenty patients had hippocampal atrophy (4 on the right side, 15 on the left side, and 1 bilateral) associated with mesial temporal sclerosis. These results confirm the existence of anatomic alterations and a left laterality effect in the mesial temporal lobe structures of patients with epileptic psychosis.
authors.affiliation: Institute and Department of Psychiatry, University of São Paulo, Rua Campevas 447, Perdizes, CEP 05016-010, São Paulo, Brazil. rlmarche@dialdata.com.br
authors.forename: Renato Luiz
authors.initials: RL
authors.lastname: Marchetti
authors.forename: Dionísio
authors.initials: D
authors.lastname: Azevedo
authors.forename: Cássio Machado
authors.initials: CM
authors.lastname: de Campos Bottino
authors.forename: Daniela
authors.initials: D
authors.lastname: Kurcgant
authors.forename: Andrea
authors.initials: A
authors.lastname: de Fátima Horvath Marques
authors.forename: Suely Kasue Nagahashi
authors.initials: SK
authors.lastname: Marie
authors.forename: Paulo Correa Vaz
authors.initials: PC
authors.lastname: de Arruda
mesh_terms: D000328:Adult; D000679:Amygdala / Q000002:abnormalities / Q000473:pathology; D001284:Atrophy / Q000453:epidemiology / Q000473:pathology; D001921:Brain / Q000002:abnormalities* / Q000473:pathology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004827:Epilepsy / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000002:abnormalities / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015588:Observer Variation; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*; D015203:Reproducibility of Results; D012598:Sclerosis / Q000453:epidemiology / Q000473:pathology; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000002:abnormalities / Q000473:pathology