title: cBlimp-1 expression in chick limb bud development.
abstract: Blimp is a transcriptional repressor that has been identified in humans, mice and frogs. Here, we describe the cloning of the gene that encodes for the chick homolog of Blimp, cBlimp-1, and the tempo-spatial expression pattern of cBlimp-1, during chick development. cBlimp-1 whose gene product shares a high level of identity with its homologs from other organisms, was found to be expressed in the apical ectodermal ridge and posterior dorsal ectoderm of developing limb buds. In addition, cBlimp-1 is expressed in the developing eyes, branchial arches and otic placodes.
authors.affiliation: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1227 BRB II/III, Philadelphia, PA 19104, USA.
authors.forename: Alice S
authors.initials: AS
authors.lastname: Ha
authors.forename: Robert D
authors.initials: RD
authors.lastname: Riddle
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002642:Chick Embryo; D020869:Gene Expression Profiling; D006801:Humans; D018878:Limb Buds / Q000196:embryology* / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D000074462:Positive Regulatory Domain I-Binding Factor 1; D012097:Repressor Proteins / Q000096:biosynthesis / Q000235:genetics*; D016415:Sequence Alignment; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*
chemical_list: C513258:Prdm1 protein, mouse; D012097:Repressor Proteins; D014157:Transcription Factors; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1