Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis.
Talalay
Paul
P
Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. ptalalay@jhmi.edu
Dinkova-Kostova
Albena T
AT
Holtzclaw
W David
WD
D000818:Animals; D000975:Antioxidants / Q000737:chemistry; D002467:Cell Nucleus / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008954:Models, Biological; D008957:Models, Genetic; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D051267:NF-E2-Related Factor 2; D009369:Neoplasms / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D017382:Reactive Oxygen Species; D015534:Trans-Activators / Q000378:metabolism
D000975:Antioxidants; D004268:DNA-Binding Proteins; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; C495636:Nfe2l2 protein, mouse; D017382:Reactive Oxygen Species; D015534:Trans-Activators; D016660:NAD(P)H Dehydrogenase (Quinone); D010100:Oxygen