title: Measles virus and dendritic cell functions: how specific response cohabits with immunosuppression.
abstract: Measles virus (MV) infection induces both an efficient MV-specific immune response and a transient but profound immunosuppression characterised by a panlymphopenia that occasionally results in opportunistic infections responsible for a high rate of mortality in children. On the basis of in vitro studies, the putative roles of dendritic cells (DCs) in MV infection are discussed. (1) DCs could participate in anti-MV innate immunity because MV turns on TNF-related apoptosis-inducing ligand (TRAIL)-mediated DC cytotoxicity. (2) Cross-priming by non-infected DCs might be the route of MV adaptive immune response. (3) After CD40-ligand activation in secondary lymphoid organs, MV-infected DCs could initiate the formation of Warthin-Finkeldey multinucleated giant cells, replicating MV and responsible for in vivo spreading of MV. (4) We review how integrated viral attack of the host immune system also targets DCs: Progress in understanding the immunobiology of MV-infected DCs that could account for MV-induced immunosuppression observed in vivo is presented and their potential role in lymphopenia is underlined. In conclusion, future research directions are proposed.
authors.affiliation: Immunobiologie Fondamentale et Clinique, CERVI-INSERM U503, 21 avenue Tony Garnier, 69007 Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Servet-Delprat
authors.forename: P O
authors.initials: PO
authors.lastname: Vidalain
authors.forename: H
authors.initials: H
authors.lastname: Valentin
authors.forename: C
authors.initials: C
authors.lastname: Rabourdin-Combe
mesh_terms: D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D019013:CD40 Antigens / Q000276:immunology; D023201:CD40 Ligand / Q000276:immunology; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology* / Q000821:virology; D006801:Humans; D007165:Immunosuppression Therapy; D008457:Measles / Q000276:immunology*; D008459:Measles virus / Q000276:immunology* / Q000502:physiology; D008562:Membrane Glycoproteins / Q000276:immunology; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D014779:Virus Replication
chemical_list: D051017:Apoptosis Regulatory Proteins; D019013:CD40 Antigens; D008562:Membrane Glycoproteins; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D014409:Tumor Necrosis Factor-alpha; D023201:CD40 Ligand