title: The efficacy of chemoradiation therapy in HIV seropositive patients with squamous cell carcinoma of the anus.
abstract: OBJECTIVE
  The aim was to assess the efficacy of chemoradiation therapy for squamous cell carcinoma of the anal canal in HIV seropositive patients.
  
  
  METHODS
  A retrospective review of all patients with squamous cell carcinoma of the anus treated primarily with combined chemotherapy (5-fluorouracil and mitomycin) and radiotherapy or local excision was undertaken comparing HIV seropositive to HIV seronegative patients.
  
  
  RESULTS
  Thirteen HIV seronegative patients were compared with 6 HIV seropositive patients. The HIV positive group included a higher proportion of males and a significantly greater history of prior treatment for condyloma. There was no difference in the median radiation dose (5020 cGy vs 4500 cGy, P=0.10). There was a trend towards higher local tumour recurrence in the HIV seropositive patients although this was not statistically significant (30% vs 66%). The CD4 count of HIV positive patients did not correlate either with their ability to complete the prescribed treatment regimen or with subsequent recurrence.
  
  
  CONCLUSIONS
  Combined chemoradiation is feasible in HIV positive patients, however, local recurrence rates in HIV positive patients may be higher. Tolerance of this therapy in HIV seropositive patients or recurrence after therapy are not related to the patient's CD4 cell count.
authors.affiliation: Department of Colorectal Surgery, Cleveland Clinic Florida, Fort Lauderdale, Florida 33331, USA. mcderme@ccf.org
authors.forename: J E
authors.initials: JE
authors.lastname: Efron
authors.forename: A J
authors.initials: AJ
authors.lastname: Pikarsky
authors.forename: P
authors.initials: P
authors.lastname: Gervaz
authors.forename: G
authors.initials: G
authors.lastname: Locker
authors.forename: E G
authors.initials: EG
authors.lastname: Weiss
authors.forename: S D
authors.initials: SD
authors.lastname: Wexner
authors.forename: J J
authors.initials: JJ
authors.lastname: Nogueras