title: On radiation hormesis expressed in the immune system.
abstract: Radiation hormesis is reviewed with emphasis on its expression in the immune system. The shape of the dose-response relationship of the immune functions depends on a number of factors, chiefly the target cell under study, experimental design with emphasis on the dose range, dose spacing, dose rate and temporal changes, as well as the animal strain. For mouse and human T lymphocyte functions in the dose range of 0.01 to 10 Gy a J or inverted J-shaped curve is usually observed. For the more radioresistant macrophages, stimulation of many of their functions is often observed in the dose range up to a few grays. The cellular and molecular mechanisms of the enhancement of immunity induced by low-dose radiation were analyzed on the basis of literature published in the last decade of the past century. Intercellular reactions among the APCs and lymphocytes via distinct changes in expression of relevant surface molecules and secretion of regulatory cytokines in response to different doses of radiation were described. The major signal transduction pathways activated in response to these intercellular reactions were illustrated. The suppressive effect of low-dose radiation on cancer induction, growth, and metastasis and its immunologic mechanisms were analyzed. The present status of research in this field gives strong support to radiation hormesis in immunity with low-dose radiation as one of the mechanisms of cancer surveillance. Further research with new techniques using microarray with biochips to fully elucidate the molecular mechanisms is suggested.
authors.affiliation: Department of Radiation Biology, Jilin University Norman Bethune Medical Center, 8 Xinmin Street, Changchun 130021, China. liushzh@jlu.edu.cnm
authors.forename: Shu-Zheng
authors.initials: SZ
authors.lastname: Liu
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007107:Immune System / Q000528:radiation effects*; D011827:Radiation; D011829:Radiation Dosage