title: Arm edema after lumpectomy and breast irradiation.
abstract: Ipsilateral arm edema can be a troublesome adverse sequel of breast conservation therapy. We carried out a prospective study of arm edema in every patient (265) seen during a 6-month period for follow-up after radiotherapy postlumpectomy for unilateral primary breast cancer. One hundred eighty-one (181) women (68.3%) had an axillary dissection. All had radiotherapy to the breast via parallel opposed tangential beams. Only eight (3%) had additional separate portals for irradiation of nodal areas. Adjuvant systemic therapy consisted of tamoxifen alone in 127 patients (47.9%) and chemotherapy with or without tamoxifen in 60 (22.6%). Ipsilateral arm edema developed in 19 patients (7.2%). Edema was mild (1+) in 16 patients, and moderate in 3 (2+). Multivariate analysis revealed that the risk of arm edema was significantly increased in heavier women (p = 0.0016), women who had an axillary dissection (p = 0.0446), and women who received tamoxifen (p = 0.0385).
authors.affiliation: University of Pittsburgh Medical Center, UPMC Presbyterian, Department of Radiation Oncology, Pittsburgh, Pennsylvania 15213, USA. deutschm@msx.upmc.edu
authors.forename: Melvin
authors.initials: M
authors.lastname: Deutsch
authors.forename: John C
authors.initials: JC
authors.lastname: Flickinger
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001132:Arm; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D004487:Edema / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008197:Lymph Node Excision / Q000009:adverse effects; D015412:Mastectomy, Segmental / Q000009:adverse effects*; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012306:Risk; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen