Surgical treatment of appendiceal mucocele.
OBJECTIVE
Clinical presentation of appendiceal mucocele is related to malignancy and can influence surgical approach.


METHODS
Retrospective study.


METHODS
Tertiary referral center.


METHODS
All cases of primary appendiceal mucoceles (simple mucocele, cystadenoma, cystadenocarcinoma) diagnosed between 1976 and 2000 were reviewed. There were 135 patients, 74 of whom were female. Mean age at diagnosis was 59 years. Mean follow-up was more than 6 years.


METHODS
A total of 129 patients underwent surgery, consisting of appendectomy (22 patients), right hemicolectomy (25 patients), or more extensive procedures (82 patients).


METHODS
Clinical, diagnostic, and surgical variables were statistically compared with postoperative morbidity and mortality and the presence of malignancy. P<.05 was considered significant.


RESULTS
The presence of symptoms was associated with malignancy (58% vs 15%, P<.001), particularly abdominal pain (56% vs 29%, P =.005) and weight loss (77% vs 31%, P =.002). Abdominal mass was also associated with malignancy (86% vs 25%, P<.001). Moreover, pseudomyxoma peritonei and mucocele extravasation were associated with malignancy (95% vs 13%, P<.001, and 83% vs 15%, P<.001, respectively). The lesion size was not associated with malignancy; however, cystadenomas were significantly larger than simple mucoceles (8.1 cm vs 4.1 cm, P<.001), and no cystadenoma was less than 2 cm in largest diameter.


CONCLUSIONS
A number of clinical, diagnostic, and intraoperative findings are associated with malignant mucoceles. All mucoceles greater than 2 cm should be excised to remove premalignant lesions.
Stocchi
Luca
L
Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minn 55905, USA.
Wolff
Bruce G
BG
Larson
Dirk R
DR
Harrington
Jeff R
JR
D001063:Appendiceal Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D003536:Cystadenocarcinoma / Q000175:diagnosis* / Q000601:surgery*; D003537:Cystadenoma / Q000175:diagnosis* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009078:Mucocele / Q000175:diagnosis* / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome