Location and intensity of IL-8 and TGF-beta2 mRNA production in the fimbrial compartment of fallopian tubes and IL-10 in the endometrium in patients with pyoinflammatory adnexal diseases.
The location and level of IL-8 and TGF-beta2 expression in the fimbrial compartment of fallopian tubes and IL-10 expression in the endometrium of women with pyoinflammatory adnexal diseases were studied by in situ hybridization. These diseases are associated with considerable changes in the levels of local production of these cytokines. Inflammatory infiltration and epithelial cells were most active producers of IL-9 and TGF-beta2 in the fimbrial compartment of fallopian tubes, while in the endometrium IL-10 gene was expressed at a high level primarily in the glandular epithelial cells.
Zhdanov
A V
AV
Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow.
Kurbanova
D F
DF
Sosulina
L Yu
LY
Davydova
M P
MP
Ezhova
L S
LS
Sukhikh
G T
GT
D000291:Adnexal Diseases / Q000276:immunology*; D000328:Adult; D004717:Endometrium / Q000737:chemistry* / Q000166:cytology; D005187:Fallopian Tubes / Q000033:anatomy & histology / Q000737:chemistry*; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D007249:Inflammation / Q000276:immunology; D016753:Interleukin-10 / Q000032:analysis* / Q000235:genetics; D016209:Interleukin-8 / Q000032:analysis* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis* / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000032:analysis* / Q000235:genetics; D053781:Transforming Growth Factor beta2
D016209:Interleukin-8; D012333:RNA, Messenger; C509041:TGFB2 protein, human; D016212:Transforming Growth Factor beta; D053781:Transforming Growth Factor beta2; D016753:Interleukin-10