title: Novel Guglielmi detachable coils (GDCs) for the treatment of brain aneurysms. In vitro study of hydroxyapatite coating on Pt plate as GDCs model.
abstract: With the use of an alternate soaking process a thin layer of hydroxyapatite (HAp) was formed on a platinum plate (Pt plate) which was used as a model for Guglielmi detachable coils (GDCs). The in vitro coagulant activity of the HAp-coated Pt plate was evaluated for the purpose of brain aneurysm treatment. In order to fix and to form the apatite layer homogeneously, beta-mercaptopropionic acid was immobilized onto the Pt surface prior to use. The HAp layer was formed on the beta-mercaptopropionic acid-fixed Pt plate surface, and quantitative control of apatite formation was achieved by controlling the number of alternate soaking process cycles. The HAp formed on the Pt plate surface was confirmed by X-ray diffraction and X-ray photoelectron spectroscopy studies. Blood interaction with the Pt plate was altered from nonthrombotic to highly thrombotic by forming a HAp layer on the surface. The alternate soaking process is an appropriate method to modify the GDCs. Complete treatment of brain aneurysms is expected with the use of HAp-coated GDCs, which would allow formation of a stable blood clot.
authors.affiliation: Department of Nanostructured and Advanced Materials, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan.
authors.forename: Michiya
authors.initials: M
authors.lastname: Matsusaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Kamezawa
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Shimozuru
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Kuratsu
authors.forename: Akio
authors.initials: A
authors.lastname: Kishida
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Akashi
mesh_terms: D015097:3-Mercaptopropionic Acid; D001672:Biocompatible Materials; D003029:Coagulants; D017886:Durapatite; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D006801:Humans; D066298:In Vitro Techniques; D002532:Intracranial Aneurysm / Q000628:therapy*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010984:Platinum; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D003029:Coagulants; D010984:Platinum; D017886:Durapatite; D015097:3-Mercaptopropionic Acid