p27KIP1 phosphorylation by PKB/Akt leads to poor breast cancer prognosis.
Clarke
Robert B
RB
Breast Biology Group, Clinical Research Department, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester, UK. RClarke@PICR.man.ac.uk
D001943:Breast Neoplasms / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology; D050760:Cyclin-Dependent Kinase Inhibitor p27; D006801:Humans; D010766:Phosphorylation; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt; D025521:Tumor Suppressor Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology
D018797:Cell Cycle Proteins; D011518:Proto-Oncogene Proteins; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; C494918:AKT1 protein, human; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt