title: Independent calculations to validate monitor units from ADAC treatment planning system.
abstract: Current standards of practice are based on the use of an independent calculation to validate the monitor units (MUs) derived from a treatment planning system. The ADAC PINNACLE treatment planning system has shown discrepancies of 10% or more compared to simple independent calculations for highly contoured areas such as tangential breast and chest wall irradiation. The ADAC treatment planning system generally requires more MUs to deliver the same prescribed dose. Independent MU calculation methods are based on full phantom conditions. On the other hand, the MUs from the ADAC treatment planning system are derived using realistic phantom scatter. As such, differences exist in TMR factors, off-axis wedge factors, and the phantom scatter factor. To systematically study the discrepancies due to phantom conditions, experimental measurements were performed with various percentages of tissue missing. The agreement between the experimental measurements and ADAC calculations was found to be within 2%. Using breast field geometry, a relationship between missing tissue and the dosimetric parameters used by ADAC was developed. This relationship, when applied, yielded independent MU calculations whose values closely matched those from the ADAC treatment planning system.
authors.affiliation: Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE, USA. akomanduri@nhsnet.org
authors.forename: Komanduri M
authors.initials: KM
authors.lastname: Ayyangar
authors.forename: Cheng B
authors.initials: CB
authors.lastname: Saw
authors.forename: Darren
authors.initials: D
authors.lastname: Gearheart
authors.forename: Bin
authors.initials: B
authors.lastname: Shen
authors.forename: Robert
authors.initials: R
authors.lastname: Thompson
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008432:Mathematical Computing; D019047:Phantoms, Imaging; D011834:Radiation Monitoring / Q000295:instrumentation* / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation* / Q000379:methods*; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012984:Software