The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty rats.
Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers of linoleic acid found in beef, lamb, and dairy products. CLA has attracted considerable attention over the past several decades because of its potentially beneficial biological effects, including protective effects against several cancers, atherosclerosis, and obesity. Here we provide the first evidence that the 10trans,12cis-CLA isomer is able to suppress increases in blood pressure during the onset of obesity in OLETF rats. After 3 weeks of feeding with 10t,12c-CLA, systolic blood pressure was significantly lowered compared with rats fed linoleic acid or 9c,11t-CLA. Abdominal adipose tissue weight was also significantly lowered in rats fed 10t,12c-CLA, but not in those which were fed 9c,11t-CLA. In addition, we found that the relative mRNA expressions of angiotensinogen and leptin were suppressed by 10t,12c-CLA in adipose tissue. We speculate that the antihypertensive effect of 10t,12c-CLA can be attributed to the lowered secretion of hypertensive adipocytokines from abdominal adipose tissues.
Nagao
Koji
K
Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, 840-8502, Saga, Japan.
Inoue
Nao
N
Wang
Yu Ming
YM
Hirata
Junichi
J
Shimada
Yuji
Y
Nagao
Toshihiro
T
Matsui
Toshiro
T
Yanagita
Teruyoshi
T
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D000808:Angiotensinogen / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*; D020738:Leptin / Q000235:genetics; D019787:Linoleic Acid / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D009765:Obesity / Q000150:complications; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D020334:Rats, Inbred OLETF; D013237:Stereoisomerism
D004042:Dietary Fats, Unsaturated; D020738:Leptin; D012333:RNA, Messenger; D000808:Angiotensinogen; D019787:Linoleic Acid