Inhibitors of diverse metabolic steps cause increased apoptosis in deoxyadenosine-resistant mouse leukemia L1210 cells that lack p53 expression: convergence at caspase-3 activation.
Cory
Ann H
AH
Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA.
Edwards
Caroline C
CC
Hall
Jennifer G
JG
Cory
Joseph G
JG
D000730:Androstadienes / Q000494:pharmacology; D000818:Animals; D017304:Annexin A5 / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017209:Apoptosis; D002087:Butyrates / Q000494:pharmacology; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism*; D002453:Cell Cycle; D045744:Cell Line, Tumor; D004396:Coloring Agents / Q000494:pharmacology; D004249:DNA Damage; D003839:Deoxyadenosines / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D019008:Drug Resistance, Neoplasm; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D019833:Genistein / Q000494:pharmacology; D007555:Isoxazoles / Q000494:pharmacology; D000077339:Leflunomide; D051379:Mice; D008954:Models, Biological; D011687:Purines / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D000077546:Roscovitine; D012717:Sesquiterpenes / Q000494:pharmacology; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism*; D000077191:Wortmannin
D000730:Androstadienes; D017304:Annexin A5; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002087:Butyrates; D004396:Coloring Agents; D003839:Deoxyadenosines; D004791:Enzyme Inhibitors; D007555:Isoxazoles; D011687:Purines; D012333:RNA, Messenger; D012717:Sesquiterpenes; D016159:Tumor Suppressor Protein p53; D000077546:Roscovitine; C002669:parthenolide; D019833:Genistein; C505409:Casp3 protein, mouse; D053148:Caspase 3; D020169:Caspases; D000077339:Leflunomide; D000077191:Wortmannin