title: Efficient and practical method for synthesizing optically active indan-2-ols by the Ti(O-i-Pr)(4)/2 i-PrMgCl-mediated metalative Reppe reaction.
abstract: An efficient and practical synthesis of optically active indan-2-ols 1 has been developed starting from readily accessible optically active 4-siloxy-1,6-alkadiynes 2 and ethynyl p-tolyl sulfone, where the metalative Reppe reaction mediated by an economical divalent titanium reagent, Ti(O-i-Pr)(4)/2 i-PrMgCl, is a key step.
authors.affiliation: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hanazawa
authors.forename: Kousuke
authors.initials: K
authors.lastname: Sasaki
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Takayama
authors.forename: Fumie
authors.initials: F
authors.lastname: Sato