[A 47-year-old man with "pure autonomic failure" and pernicious anemia].
METHODS
A 47-year-old man with a known and substituted vitamin B12 deficiency presented with increasing symptoms associated with orthostatic hypotension, neck pain and micturitional and visual disturbances.


METHODS
Catecholamines were strongly reduced in plasma and urine.


METHODS
A pure autonomic failure was diagnosed and therapy with fludrocortisone, yohimbine and erythropoetine was started. Symptoms with the exception of micturitional disturbances improved strongly.


CONCLUSIONS
Multiple-drug treatment of pure autonomic failure is successful. The prognosis is good.
Fehmann
H C
HC
Praxis für Innere Medizin, Diabetologische Schwerpunktpraxis, Marburg.
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000752:Anemia, Pernicious / Q000150:complications* / Q000188:drug therapy; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D001794:Blood Pressure; D002395:Catecholamines / Q000097:blood / Q000652:urine; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000627:therapeutic use; D005438:Fludrocortisone / Q000627:therapeutic use; D006801:Humans; D007024:Hypotension, Orthostatic; D008297:Male; D008875:Middle Aged; D008901:Mineralocorticoids / Q000627:therapeutic use; D019547:Neck Pain; D011379:Prognosis; D011674:Pulse; D014555:Urination Disorders; D014786:Vision Disorders; D014805:Vitamin B 12 / Q000627:therapeutic use; D015016:Yohimbine / Q000627:therapeutic use
D000317:Adrenergic alpha-Antagonists; D002395:Catecholamines; D008901:Mineralocorticoids; D004921:Erythropoietin; D015016:Yohimbine; D014805:Vitamin B 12; D005438:Fludrocortisone