The dexamethasone suppression test and CSF-5-HIAA in relation to suicidality and depression in suicide attempters.
This study tested suicidality in relation to cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) and the dexamethasone suppression test. Patients with nonsuppression of cortisol had the highest scores of the Suicide Assessment Scale (SUAS) and the Montgomery Asberg Depression Rating Scale (MADRS), respectively (P < 0.05; P < 0.01). The results persisted when analysed for covariance with CSF-5-HIAA. We have previously noted an elevated suicide risk in suicide attempters with high SUAS-scores, why a large part of nonsuppressors may be at high risk for future suicide.
Westrin
Asa
A
Department of Clinical Neuroscience, Division of Psychiatry, Lund University, 221 85 Lund, Sweden. asa.westrin@psykiatr.lu.se
Niméus
Anders
A
D000328:Adult; D003866:Depressive Disorder / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D003907:Dexamethasone; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D011237:Predictive Value of Tests; D012306:Risk; D013405:Suicide / Q000523:psychology; D013406:Suicide, Attempted / Q000517:prevention & control / Q000523:psychology*; D000092864:Suicide Prevention
D006897:Hydroxyindoleacetic Acid; D003907:Dexamethasone; D006854:Hydrocortisone