title: A bacterial toxin that causes DNA damage to modulate cellular responses.
abstract: Campylobacter jejuni constitutes the leading cause of bacterial diarrhea in the U.S. and all around the world. This common bacterium produces a toxin known as cytolethal distending toxin (CDT) which causes intoxicated cells to enlarge and to stop dividing with a double DNA content characteristic of G2/M arrest. The effect of the toxin on the cell is so striking that it captivated scientists for a long time. However, its mechanism of action had remained elusive.
authors.affiliation: Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale School of Medicine, New Haven, CT 06536, USA. maria.lara-tejero@yale.edu
authors.forename: M
authors.initials: M
authors.lastname: Lara-Tejero
mesh_terms: D001427:Bacterial Toxins / Q000633:toxicity*; D002169:Campylobacter Infections / Q000473:pathology; D016123:Campylobacter jejuni / Q000472:pathogenicity; D004249:DNA Damage / Q000187:drug effects; D016195:G2 Phase / Q000187:drug effects*; D005786:Gene Expression Regulation / Q000187:drug effects
chemical_list: D001427:Bacterial Toxins; C067044:cytolethal distending toxin