Intravenous pharmacokinetics of penicillin G and antipyrine in ostriches (Struthio camelus) and emus (Dromaius novaehollandiae).
Penicillin G and antipyrine, which served as model drugs to assess the relative capacities of renal and hepatic elimination pathways, respectively, were each administered intravenously to six ostriches (Struthio camelus) and to six emus (Dromaius novaehollandiae). Drug concentrations in blood samples collected over a period of 12 hr after administration were assayed, and elimination half-life, mean residence time, clearance, and steady-state volume of distribution were calculated. Mean values for elimination half-life and mean residence time of penicillin G were significantly higher in emus than in ostriches; no significant differences in antipyrine pharmacokinetics between species were demonstrated.
Clarke
C R
CR
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma 74078, USA.
Kocan
A A
AA
Webb
A I
AI
Wang
Z
Z
Cudd
L A
LA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D000983:Antipyrine / Q000493:pharmacokinetics*; D020312:Dromaiidae / Q000378:metabolism*; D006207:Half-Life; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008657:Metabolic Clearance Rate; D010400:Penicillin G / Q000493:pharmacokinetics*; D010406:Penicillins / Q000493:pharmacokinetics; D013045:Species Specificity; D020310:Struthioniformes / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010406:Penicillins; D010400:Penicillin G; D000983:Antipyrine