title: Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents.
abstract: We have prepared and evaluated the antibacterial activities of a series of substituted methylenepiperidinyl and methylenepyrrolidinyl oxazolidinones against several gram-positive strains including the resistant strains of Staphyloccus and Enterococcus, such as MRSA, CRSA, MSSA and VRE. Some of them showed comparable or superior in vitro activities (MIC) to vancomycin.
authors.affiliation: Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, 130-650, Seoul, South Korea. hykoh@kist.re.kr
authors.forename: Hye Yeon
authors.initials: HY
authors.lastname: Kim
authors.forename: Jae Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Joo Hwan
authors.initials: JH
authors.lastname: Cha
authors.forename: Ae Nim
authors.initials: AN
authors.lastname: Pae
authors.forename: Yong Seo
authors.initials: YS
authors.lastname: Cho
authors.forename: Moon Ho
authors.initials: MH
authors.lastname: Chang
authors.forename: Hun Yeong
authors.initials: HY
authors.lastname: Koh
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D019540:Area Under Curve; D001419:Bacteria / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D016983:Enterococcus / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007202:Indicators and Reagents; D008297:Male; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D013210:Staphylococcus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D007202:Indicators and Reagents; D010080:Oxazoles; D010880:Piperidines; D011759:Pyrrolidines; C482000:methylenepiperidinyl oxazolidinone; C481999:methylenepyrrolidinyl oxazolidinone; D014640:Vancomycin