title: Concurrent follicular dysplasia and interface dermatitis in Boxer dogs.
abstract: Recurrent or persistent follicular dysplasia and interface dermatitis are described in nine Boxers. Data on age, sex, seasonality of alopecia and histopathological features of the follicular dysplasia in these nine Boxers are comparable with those described in previous reports. The interface dermatitis was characterized by multifocal annular crusted lesions confined to the areas of follicular dysplasia. The inflammatory lesions were neither pruritic nor painful and affected dogs were otherwise healthy. Histopathologically the clinically inflammatory lesions were characterized as an interface dermatitis. Immunohistochemical studies failed to demonstrate immunoglobulins or complement at the basement membrane zone or within blood vessel walls. In dogs with recurrent or persistent disease, the follicular dysplasia and interface dermatitis ran identical, concurrent courses of spontaneous remission and recurrence, or persistence, respectively. One dog with persistent disease was treated successfully with tetracycline and niacinamide for the interface dermatitis, and melatonin for the follicular dysplasia. Although the aetiopathogenesis of this newly described condition and the relationship between the two histological reaction patterns are not known, photoperiod and genetic predisposition appear to play a role.
authors.affiliation: Departments of Biomedical Sciences and Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Milene A
authors.initials: MA
authors.lastname: Rachid
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Demaula
authors.forename: Danny W
authors.initials: DW
authors.lastname: Scott
authors.forename: William H
authors.initials: WH
authors.lastname: Miller
authors.forename: David A
authors.initials: DA
authors.lastname: Senter
authors.forename: Sherry
authors.initials: S
authors.lastname: Myers
mesh_terms: D000818:Animals; D003872:Dermatitis / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D004285:Dogs; D005260:Female; D005499:Folliculitis / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D009536:Niacinamide / Q000008:administration & dosage; D010808:Physical Examination / Q000662:veterinary; D013577:Syndrome; D013752:Tetracycline / Q000008:administration & dosage
chemical_list: D009536:Niacinamide; D013752:Tetracycline