title: Evaluation of antipyretic potential of Cleome viscosa Linn. (Capparidaceae) extract in rats.
abstract: The antipyretic activity of a methanol extract of Cleome viscosa Linn. (CVME) was investigated for its potential on normal body temperature and yeast-induced pyrexia in albino rats. The CVME, at doses of 200, 300, and 400mg/kg BW p.o., showed significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose-dependent manner. The effect also extended upto 5h after the drug administration. The anti-pyretic effect of CVME was comparable to that of paracetamol (150mg/kg p.o.), a standard anti-pyretic agent.
authors.affiliation: Division of Pharmacognosy, Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadavpur University, Calcutta 700032, India.
authors.forename: B Parimala
authors.initials: BP
authors.lastname: Devi
authors.forename: R
authors.initials: R
authors.lastname: Boominathan
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Mandal
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D031485:Cleome / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D009181:Mycoses / Q000150:complications; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D000082:Acetaminophen