Volumetric evidence of a left laterality effect in epileptic psychosis.
We investigated anatomic alterations and lateralization effect in the mesial temporal lobe structures (amygdala and hippocampus) in epileptic psychosis MRI volumetric measurements. Patients with epileptic psychosis and normal controls were studied. Left hippocampus values were significantly smaller for patients (P<0.001). Hippocampal ratio was significantly greater for patients (P<0.01). Group (patients x normal) was the only factor explaining the statistically significant variation of left hippocampus and hippocampal ratio (P<0.001 and P<0.05). Twenty patients had hippocampal atrophy (4 on the right side, 15 on the left side, and 1 bilateral) associated with mesial temporal sclerosis. These results confirm the existence of anatomic alterations and a left laterality effect in the mesial temporal lobe structures of patients with epileptic psychosis.
Marchetti
Renato Luiz
RL
Institute and Department of Psychiatry, University of São Paulo, Rua Campevas 447, Perdizes, CEP 05016-010, São Paulo, Brazil. rlmarche@dialdata.com.br
Azevedo
Dionísio
D
de Campos Bottino
Cássio Machado
CM
Kurcgant
Daniela
D
de Fátima Horvath Marques
Andrea
A
Marie
Suely Kasue Nagahashi
SK
de Arruda
Paulo Correa Vaz
PC
D000328:Adult; D000679:Amygdala / Q000002:abnormalities / Q000473:pathology; D001284:Atrophy / Q000453:epidemiology / Q000473:pathology; D001921:Brain / Q000002:abnormalities* / Q000473:pathology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004827:Epilepsy / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000002:abnormalities / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015588:Observer Variation; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*; D015203:Reproducibility of Results; D012598:Sclerosis / Q000453:epidemiology / Q000473:pathology; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000002:abnormalities / Q000473:pathology