title: Drosophila melanogaster antimicrobial defense.
abstract: The Drosophila melanogaster host defense is complex but remarkably efficient. It is a multifaceted response to a variety of fungal, bacterial, and parasitic invaders. Current knowledge is discussed on recognition of infectious microorganisms and on the activation of intracellular signaling cascades that concur with the expression of numerous immune-responsive genes, among which, to date, the most prominent appear to encode potent antimicrobial peptides.
authors.affiliation: Institut de Biologie Moléculaire et Cellulaire, UPR9022 du Centre National de la Recherche Scientifique, Strasbourg, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Hetru
authors.forename: Laurent
authors.initials: L
authors.lastname: Troxler
authors.forename: Jules A
authors.initials: JA
authors.lastname: Hoffmann
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology; D004331:Drosophila melanogaster / Q000235:genetics / Q000276:immunology*; D007113:Immunity, Innate; D009181:Mycoses / Q000276:immunology; D010273:Parasitic Diseases, Animal / Q000276:immunology; D010455:Peptides / Q000276:immunology; D015398:Signal Transduction
chemical_list: D010455:Peptides