title: Comparative analysis of lipid profiles among patients with type 2 diabetes mellitus, hypertension and concurrent type 2 diabetes, and hypertension: a view of metabolic syndrome.
abstract: Type 2 diabetes mellitus and hypertension are independent risk factors for atherosclerotic lesions that are partly linked with dyslipidaemia. This risk is additive when diabetes and hypertension occur concurrently. In order to determine if concurrent type 2 diabetes and hypertension results in putative increases in dyslipidaemia in a Nigerian population, we compared the plasma lipid levels, atherogenic index and prevalence of dyslipidaemia among age and sex-matched indigenous Nigerians with type 2 diabetes, hypertension and concurrent diabetes and hypertension. Age and sex-matched healthy Nigerians that are free of diabetes and hypertension served as controls. The patients as a whole were more likely to have dyslipidaemia than controls (p < 0.05). High-density lipoprotein cholesterol was similar among patients and controls. Mean total cholesterol, high-density lipoprotein cholesterol; low-density lipoprotein cholesterol and triglyceride levels, atherogenic index and prevalence of dyslipidaemia did not differ significantly among patients with hypertension, diabetes, and concurrent hypertension and diabetes (p = 0.99 for each parameter). It is concluded that concurrent hypertension and type 2 diabetes does not result in a more severe dyslipidaemia than when either of the two conditions occurs in isolation. We attribute this to the common pathogenic link between hypertension, diabetes and dyslipidaemia in metabolic syndrome. Evidence, albeit indirect, of this syndrome among native Africans is, therefore, provided.
authors.affiliation: Department of Medicine, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. sisezuo@skannet.com
authors.forename: S A
authors.initials: SA
authors.lastname: Isezuo
authors.forename: S L H
authors.initials: SL
authors.lastname: Badung
authors.forename: A B O
authors.initials: AB
authors.lastname: Omotoso
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D050171:Dyslipidemias; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008055:Lipids; D024821:Metabolic Syndrome / Q000097:blood; D012307:Risk Factors
chemical_list: D008055:Lipids