title: Erythromycin induces pyloric relaxation accompanied by a contraction of the gastric body after pylorus-preserving gastrectomy.
abstract: BACKGROUND
  Pylorus-preserving gastrectomy (PPG) is a function-preserving surgery; however, long-term retention of food in the residual stomach is a frequent complication during the early postoperative period. We reported that gastric stasis after PPG was attributable to the delayed recovery of gastric phase III, in which pyloric relaxation accompanied a contraction of the gastric body. The objective of the present study is to determine whether erythromycin can induce phase III with pyloric relaxation after PPG.
  
  
  METHODS
  We studied gastrointestinal motility in dogs after PPG by using strain gauge force transducer. After randomized administration of either erythromycin or saline, interdigestive gastropyloroduodenal motility was recorded.
  
  
  RESULTS
  Erythromycin induced phase III with pyloric relaxation in the early postoperative period. Pyloric relaxation accompanied a contraction of the gastric body. Compared with the saline group (body: 87.2 +/- 16.7 mmHg x min, antrum: 69.7 +/- 13.7 mmHg x min, pylorus: 91.7 +/- 22.1 mmHg x min), the erythromycin group showed significantly increased gastropyloric motility indexes (body: 506.2 +/- 33.5 mmHg x min, antrum: 430.9 +/- 53.7 mmHg x min, pylorus: 589.5 +/- 59.5 mmHg x min).
  
  
  CONCLUSIONS
  Erythromycin can induce phase III, in which pyloric relaxation accompanied a contraction of the gastric body in the early postoperative period after PPG. Erythromycin might be used as a prokinetic agent for the treatment of early gastric stasis after PPG.
authors.affiliation: First Department of Surgery, Faculty of Medicine, Gunma University, Maebashi, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nakabayashi
authors.forename: Erito
authors.initials: E
authors.lastname: Mochiki
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kamiyama
authors.forename: Norihiro
authors.initials: N
authors.lastname: Haga
authors.forename: Takayuki
authors.initials: T
authors.lastname: Asao
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuwano
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D004917:Erythromycin / Q000494:pharmacology*; D005743:Gastrectomy / Q000379:methods*; D005746:Gastric Emptying / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D011708:Pylorus / Q000187:drug effects* / Q000502:physiology / Q000601:surgery; D013270:Stomach / Q000294:innervation
chemical_list: D004917:Erythromycin; D001285:Atropine