Proliferative activity of microvascular cells in glioblastomas does not correlate with time to recurrence.
The time to recurrence operation (TR) is a good growth parameter, in particular for glioblastomas. Recently, we have shown that Ki-67 labeling index (LI) of tumor cells has a high inverse correlation with this time interval. In the current study, the LI of microvascular cells (MVC) was examined in the same glioblastoma cases. The LI of MVC of primary and recurrent tumors had no relationship and did not show any correlation to TR. The growth fraction of MVC was significantly lower than that of tumor cells. The MVC in glioblastomas seems to have chaotical proliferation properties without any link to the tumor growth potential. This observation may have implications for anti-angiogenic therapy.
Kern
Michael A
MA
Department of Neuropathology, University of Cologne, Germany.
Feisel
Klaus D
KD
Friese
Michael
M
Ernestus
Ralf-Ingo
RI
Schröder
Roland
R
D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000098:blood supply* / Q000473:pathology; D002455:Cell Division; D005260:Female; D005909:Glioblastoma / Q000098:blood supply* / Q000473:pathology; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology*; D011237:Predictive Value of Tests; D013997:Time Factors
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen