[Na/K pump and intracellular monovalent cations: novel mechanism of excitation-transcription coupling involved in inhibition of apoptosis].
The Na/K pump plays a key role in the regulation of the intracellular concentrations of monovalent cations and related cell function leading to electrogenesis and excitation-contraction coupling. We focus this review on the analysis of recent data showing that (i) inhibition of the Na/K pump triggers a signaling cascade independently of modulation of the intracellular [Na+]i/[K+]i ratio; (ii) elevation of [Na+]i under sustained inhibition of the Na/K pump leads to expression of a set of genes by [Ca2+]i-dependent and independent pathways; (iii) [Na+]i-sensitive genes are involved in the inhibition of programmed cell death (apoptosis) in vascular smooth muscle cells.
Taurin
S
S
Research Centre, University of Montreal Hospital (CHUM), Canada.
Hamet
P
P
Orlov
S N
SN
D017209:Apoptosis / Q000502:physiology*; D020013:Calcium Signaling; D002414:Cations, Monovalent / Q000378:metabolism*; D005786:Gene Expression Regulation; D008564:Membrane Potentials / Q000502:physiology; D011188:Potassium / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid; D015398:Signal Transduction; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D002414:Cations, Monovalent; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium