Family-based association study of markers on chromosome 22 in schizophrenia using African-American, European-American, and Chinese families.
Several studies suggest that loci at chromosome 22q11.2-q13 might be linked to susceptibility to schizophrenia. Here we performed family-based association studies on chromosome 22q using 12 DNA microsatellite markers in African-American, European-American, and Chinese pedigrees. The marker D22S683 showed significant linkage and association with schizophrenia in not only the European-American sample but also in a combined sample (European-American and Chinese samples). Notably, D22S683 is located nearby and between D22S278 and D22S283, which have shown linkage and association to schizophrenia in prior reports. However, we found no significant association for the African-American sample. In conclusion, our data provide further support for the idea that the region around D22S683 contains a susceptibility gene for schizophrenia.
Takahashi
Sakae
S
Department of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts 02115, USA.
Cui
Yu-Hu
YH
Kojima
Takuya
T
Han
Yong-Hua
YH
Zhou
Ru-Lum
RL
Kamioka
Masashi
M
Yu
Shun-Ying
SY
Matsuura
Masato
M
Matsushima
Eisuyke
E
Wilcox
Marsha
M
Arinami
Tadao
T
Shen
Yu-Cun
YC
Faraone
Stephen V
SV
Tsuang
Ming T
MT
D000328:Adult; D044466:Asian People / Q000235:genetics*; D044383:Black People / Q000208:ethnology / Q000235:genetics*; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009679:Nuclear Family; D010375:Pedigree; D012559:Schizophrenia / Q000235:genetics*; D044465:White People / Q000208:ethnology / Q000235:genetics*; D001741:Black or African American
D005819:Genetic Markers