[Insufficiency of nigrostriatal dopaminergic system as a disregulation mechanism of dopamine-dependent depression syndrome].
Considered here, is a role of insufficiency of central dopaminergic systems in the pathogenesis of depression. Experimental data have been obtained in a rat model of depression-like syndrome caused by administration of specific-for-dopamine-neurons neurotoxin 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine. Along with literature data, these results suggest a reduction of dopaminergic system activity in striatum, accompanied by the latter's hyperactivation, as a pathophysiological mechanism for development of certain depressive disorders.
Krupina
N A
NA
Kryzhanovskiĭ
G N
GN
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D003866:Depressive Disorder / Q000139:chemically induced / Q000378:metabolism*; D004195:Disease Models, Animal; D004298:Dopamine / Q000172:deficiency / Q000378:metabolism*; D015259:Dopamine Agents; D051381:Rats; D017208:Rats, Wistar
D015259:Dopamine Agents; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine