Erythromycin induces pyloric relaxation accompanied by a contraction of the gastric body after pylorus-preserving gastrectomy.
BACKGROUND
Pylorus-preserving gastrectomy (PPG) is a function-preserving surgery; however, long-term retention of food in the residual stomach is a frequent complication during the early postoperative period. We reported that gastric stasis after PPG was attributable to the delayed recovery of gastric phase III, in which pyloric relaxation accompanied a contraction of the gastric body. The objective of the present study is to determine whether erythromycin can induce phase III with pyloric relaxation after PPG.


METHODS
We studied gastrointestinal motility in dogs after PPG by using strain gauge force transducer. After randomized administration of either erythromycin or saline, interdigestive gastropyloroduodenal motility was recorded.


RESULTS
Erythromycin induced phase III with pyloric relaxation in the early postoperative period. Pyloric relaxation accompanied a contraction of the gastric body. Compared with the saline group (body: 87.2 +/- 16.7 mmHg x min, antrum: 69.7 +/- 13.7 mmHg x min, pylorus: 91.7 +/- 22.1 mmHg x min), the erythromycin group showed significantly increased gastropyloric motility indexes (body: 506.2 +/- 33.5 mmHg x min, antrum: 430.9 +/- 53.7 mmHg x min, pylorus: 589.5 +/- 59.5 mmHg x min).


CONCLUSIONS
Erythromycin can induce phase III, in which pyloric relaxation accompanied a contraction of the gastric body in the early postoperative period after PPG. Erythromycin might be used as a prokinetic agent for the treatment of early gastric stasis after PPG.
Nakabayashi
Toshihiro
T
First Department of Surgery, Faculty of Medicine, Gunma University, Maebashi, Japan.
Mochiki
Erito
E
Kamiyama
Yoichi
Y
Haga
Norihiro
N
Asao
Takayuki
T
Kuwano
Hiroyuki
H
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D004917:Erythromycin / Q000494:pharmacology*; D005743:Gastrectomy / Q000379:methods*; D005746:Gastric Emptying / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D011708:Pylorus / Q000187:drug effects* / Q000502:physiology / Q000601:surgery; D013270:Stomach / Q000294:innervation
D004917:Erythromycin; D001285:Atropine