Priming and expression of immune responses in the gastric mucosa.
This review deals with the induction and expression of immune responses in the human stomach following mucosal immunisation. As prerequisites for developing a Helicobacter pylori vaccine, the role of gastric inflammation, in particular inflammation induced by H. pylori infection, as well as lymphocyte homing within the common mucosal immune system, and the importance of immunisation route are discussed.
Svennerholm
Ann-Mari
AM
Department of Medical Microbiology and Immunology, Göteborg University Vaccine Research Institute (GUVAX), Göteborg University, P.O. Box 435, 405 30 Göteborg, Sweden. ann-mari.svennerholm@microbio.gu.se
Quiding-Järbrink
Marianne
M
D000818:Animals; D005753:Gastric Mucosa / Q000276:immunology*; D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007110:Immunity, Active; D007111:Immunity, Cellular; D018928:Immunity, Mucosal; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D014611:Vaccination