title: Molecular evolution and recombination in gender-associated mitochondrial DNAs of the Manila clam Tapes philippinarum.
abstract: Doubly uniparental inheritance (DUI) provides an intriguing system for addressing aspects of molecular evolution and intermolecular recombination of mitochondrial DNA. For this reason, a large sequence analysis has been performed on Tapes philippinarum (Bivalvia, Veneridae), which has mitochondrial DNA heteroplasmy that is consistent with a DUI. The sequences of a 9.2-kb region (containing 29 genes) from 9 individuals and the sequences of a single gene from another 44 individuals are analyzed. Comparisons suggest that the two sex-related mitochondrial genomes do not experience a neutral pattern of divergence and that selection may act with varying strength on different genes. This pattern of evolution may be related to the long, separate history of M and F genomes within their tissue-specific "arenas." Moreover, our data suggest that recombinants, although occurring in soma, may seldom be transmitted to progeny in T. philippinarum.
authors.affiliation: Dipartimento di Biologia Evoluzionistica Sperimentale, Università degli Studi di Bologna, Italy. mpassa@alma.unibo.it
authors.forename: Marco
authors.initials: M
authors.lastname: Passamonti
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Boore
authors.forename: Valerio
authors.initials: V
authors.lastname: Scali
mesh_terms: D000818:Animals; D001483:Base Sequence; D049872:Bivalvia; D004272:DNA, Mitochondrial; D019143:Evolution, Molecular; D005111:Extrachromosomal Inheritance; D005260:Female; D014644:Genetic Variation; D016678:Genome; D008297:Male; D008957:Models, Genetic; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012335:RNA, Ribosomal / Q000235:genetics / Q000378:metabolism; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D012737:Sex Factors
chemical_list: D004272:DNA, Mitochondrial; D012335:RNA, Ribosomal