title: Antimicrobial diterpenes from the seeds of Cephalotaxus harringtonia var. drupacea.
abstract: Six diterpenes, including two new natural products, were isolated from the seeds of Cephalotaxus harringtonia. The new metabolites were characterised as 8 beta-hydroxy-9(11),13-abietadien-12-one and 5,6-didehydroferruginol, while the known compounds were identified as ferruginol, sugiol, 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one, and abieta-8,11,13-trien-7 beta-ol. These compounds were studied in vitro for their antimicrobial activity against clinically isolated bacteria and Candida strains. Ferruginol and 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one showed antimicrobial activity against Gram-positive bacteria. None of the six diterpenes was active against the Gram-negative organisms and yeasts tested.
authors.forename: Matteo
authors.initials: M
authors.lastname: Politi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Braca
authors.forename: Nunziatina
authors.initials: N
authors.lastname: De Tommasi
authors.forename: Ivano
authors.initials: I
authors.lastname: Morelli
authors.forename: Antonio
authors.initials: A
authors.lastname: Manunta
authors.forename: Lucia
authors.initials: L
authors.lastname: Battinelli
authors.forename: Gabriela
authors.initials: G
authors.lastname: Mazzanti
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects; D032483:Cephalotaxus; D004224:Diterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D012639:Seeds
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D004224:Diterpenes; D010936:Plant Extracts