title: In vitro analysis of the wear, wear debris and biological activity of surface-engineered coatings for use in metal-on-metal total hip replacements.
abstract: Extremely low wear rates have been reported for metal-on-metal total hip replacements, but concerns remain about the effects of metal ion release, dissolution rates and toxicity. Surface-engineered coatings have the potential to improve wear resistance and reduce the biological activity of the wear debris produced. The aim of this study was to examine the wear and wear debris generation from surface-engineered coatings: titanium nitride (TiN), chromium nitride (CrN) and chromium carbon nitride (CrCN) applied to a cobalt-chrome alloy (CoCr) substrate. The coatings were articulated against themselves in a simple geometry model. The wear particles generated were characterized and the cytotoxic effect on U937 macrophages and L929 fibroblasts assessed. The CrN and CrCN coatings showed a decrease in wear compared to the CoCr bearings and produced small (less than 40 nm in length) wear particles. The wear particles released from the surface engineered bearings also showed a decreased cytotoxic effect on cells compared to the CoCr alloy debris. The reduced wear volumes coupled with the reduced cytotoxicity per unit volume of wear indicate the potential for the clinical application of this technology.
authors.affiliation: School of Mechanical Engineering, University of Leeds, UK.
authors.forename: S
authors.initials: S
authors.lastname: Williams
authors.forename: J L
authors.initials: JL
authors.lastname: Tipper
authors.forename: E
authors.initials: E
authors.lastname: Ingham
authors.forename: M H
authors.initials: MH
authors.lastname: Stone
authors.forename: J
authors.initials: J
authors.lastname: Fisher
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002858:Chromium Alloys / Q000737:chemistry / Q000633:toxicity*; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000633:toxicity*; D018920:Coculture Techniques; D019544:Equipment Failure Analysis / Q000379:methods; D005347:Fibroblasts / Q000187:drug effects; D017276:Friction; D006622:Hip Prosthesis; D006801:Humans; D008422:Materials Testing / Q000379:methods; D008670:Metals / Q000737:chemistry / Q000633:toxicity; D008854:Microscopy, Electron; D009532:Nickel / Q000737:chemistry / Q000633:toxicity*; D011095:Polyethylenes; D011475:Prosthesis Failure; D012016:Reference Values; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry / Q000633:toxicity*; D020298:U937 Cells / Q000187:drug effects
chemical_list: D002858:Chromium Alloys; D020099:Coated Materials, Biocompatible; D008670:Metals; D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene; C040654:titanium nickelide; D009532:Nickel; D014025:Titanium