title: Telomerase reactivation in malignant gliomas and loss of heterozygosity on 10p15.1.
abstract: An inhibitor of telomerase activity maps to chromosome 10p15.1. A series of 51 high-grade gliomas was analyzed for loss of heterozygosity (LOH) on chromosome 10 and for telomerase activity. In univariate analysis, LOH10p (59%) and LOH10q (61%) were associated with telomerase activity (55%; p < 0.0001 and p = 0.0006). In multivariate analysis, only LOH10p remained statistically related to telomerase activity, suggesting that the telomerase repressor gene located on 10p15.1 is inactivated in high-grade gliomas.
authors.affiliation: INSERM U495, Groupe hospitalier Pitié-Salpêtrière and Université Pierre et Marie Curie, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Leuraud
authors.forename: L
authors.initials: L
authors.lastname: Aguirre-Cruz
authors.forename: K
authors.initials: K
authors.lastname: Hoang-Xuan
authors.forename: E
authors.initials: E
authors.lastname: Crinière
authors.forename: M-L
authors.initials: ML
authors.lastname: Tanguy
authors.forename: J-L
authors.initials: JL
authors.lastname: Golmard
authors.forename: M
authors.initials: M
authors.lastname: Kujas
authors.forename: J-Y
authors.initials: JY
authors.lastname: Delattre
authors.forename: M
authors.initials: M
authors.lastname: Sanson
mesh_terms: D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D005910:Glioma / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D019656:Loss of Heterozygosity; D019098:Telomerase / Q000378:metabolism*
chemical_list: D019098:Telomerase