An eye on insulin.
Diabetic retinopathy, the most frequent complication of diabetes and leading cause of vision loss, involves vascular and neural damage in the retina. Insulin and IGF-1 signaling are now shown to contribute to retinal neovascularization, in part, by modulating the expression of various vascular mediators.
Bronson
Sarah K
SK
Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA.
Reiter
Chad E N
CE
Gardner
Thomas W
TW
D000818:Animals; D003930:Diabetic Retinopathy / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D017526:Receptor, IGF Type 1 / Q000502:physiology; D011972:Receptor, Insulin / Q000502:physiology; D012171:Retinal Vessels / Q000473:pathology
D007328:Insulin; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1; D011972:Receptor, Insulin