Behavioral phenotyping of rodents.
Established methods for analyzing behavioral traits in mutant lines of mice allow researchers to understand the outcomes of genetic manipulations in the nervous system. A rigorous six-tiered behavioral phenotyping strategy is described. Recommendations are offered for the design of mouse behavioral testing suites in animal housing facilities.
Crawley
Jacqueline N
JN
Section on Behavioral Genomics, Intramural Research Program, National Institute of Mental Health, Building 10 Room 4D11, Bethesda, Maryland, USA.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001525:Behavioral Sciences / Q000295:instrumentation / Q000379:methods; D005824:Genetics, Behavioral; D006799:Housing, Animal; D007756:Laboratory Animal Science / Q000295:instrumentation / Q000379:methods; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics / Q000523:psychology*; D010641:Phenotype; D012931:Social Environment; D014730:Veterinary Medicine / Q000379:methods