Serum p53 antibodies in correlation to other biological parameters of breast cancer.
Breast cancer is the second most frequent cancer of Thai women. Mutation of p53 is a common event in breast cancer. This alteration can result in cellular accumulation of p53 and may also found in serum p53 antibodies (p53-Abs). To clarify prognostic significance of these antibodies, we evaluated p53-Abs in 158 sera of patients with breast cancer. Thirty (19%) patients were found to have p53-Abs. The incidence of p53-Abs tended to be higher in patients with advanced disease group (stages III and IV) than patients with early disease group (stages I and II) (P=0.055). Strong correlations were found between the presence of p53-Abs and p53 protein expression (P<0.001) and lymph node status (P=0.021). The presence of p53-Abs was associated with lack of estrogen (ER) receptor expression (P=0.035) but was not related to progesterone receptor (PR) (P=0.567). In addition, there was a statistically significant correlation between p53-Abs and proliferation associated antigen Ki-67 (P=0.006), but no relation between c-erbB2 oncoprotein and p53-Abs was observed (P=0.112). Additionally, no correlation was noted between the presence of p53-Abs and serum carcinoembryonic antigen (CEA) or carbohydrate antigen (CA15-3). Our findings indicate that p53-Abs appears to be a promising new parameter to evaluate the cellular biology and prognosis of breast cancer.
Sangrajrang
S
S
Research Division, National Cancer Institute, Rama VI Road Ratchatewi, Bangkok 10400, Thailand. sulee@health.moph.go.th
Arpornwirat
W
W
Cheirsilpa
A
A
Thisuphakorn
P
P
Kalalak
A
A
Sornprom
A
A
Soussi
T
T
D000328:Adult; D000368:Aged; D000912:Antibodies, Neoplasm / Q000097:blood* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000097:blood / Q000276:immunology* / Q000473:pathology; D002467:Cell Nucleus / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D004967:Estrogens / Q000097:blood; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000302:isolation & purification; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000302:isolation & purification; D011960:Receptors, Estrogen / Q000302:isolation & purification; D011980:Receptors, Progesterone / Q000302:isolation & purification; D016159:Tumor Suppressor Protein p53 / Q000276:immunology* / Q000378:metabolism
D000912:Antibodies, Neoplasm; D001323:Autoantibodies; D014408:Biomarkers, Tumor; D004967:Estrogens; D019394:Ki-67 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D016159:Tumor Suppressor Protein p53