title: Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep.
abstract: In rodents, the electroencephalogram (EEG) during paradoxical sleep and exploratory behavior is characterized by theta oscillations. Here we show that a deficiency in short-chain acyl-coenzyme A dehydrogenase (encoded by Acads) in mice causes a marked slowing in theta frequency during paradoxical sleep only. We found Acads expression in brain regions involved in theta generation, notably the hippocampus. Microarray analysis of gene expression in mice with mutations in Acads indicates overexpression of Glo1 (encoding glyoxylase 1), a gene involved in the detoxification of metabolic by-products. Administration of acetyl-L-carnitine (ALCAR) to mutant mice significantly recovers slow theta and Glo1 overexpression. Thus, an underappreciated metabolic pathway involving fatty acid beta-oxidation also regulates theta oscillations during sleep.
authors.affiliation: Biochemistry and Genetics Unit, Department of Psychiatry, University of Geneva and Geneva University Hospitals, Chemin du Petit-Bel-Air 2, 1225 Chêne-Bourg, Switzerland. mehdi.tafti@medecine.unige.ch
authors.forename: Mehdi
authors.initials: M
authors.lastname: Tafti
authors.forename: Brice
authors.initials: B
authors.lastname: Petit
authors.forename: Didier
authors.initials: D
authors.lastname: Chollet
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Neidhart
authors.forename: Fabienne
authors.initials: F
authors.lastname: de Bilbao
authors.forename: Jozsef Z
authors.initials: JZ
authors.lastname: Kiss
authors.forename: Philip A
authors.initials: PA
authors.lastname: Wood
authors.forename: Paul
authors.initials: P
authors.lastname: Franken
mesh_terms: D000108:Acetylcarnitine / Q000008:administration & dosage; D042964:Acyl-CoA Dehydrogenase; D000818:Animals; D001921:Brain / Q000201:enzymology*; D004195:Disease Models, Animal; D004569:Electroencephalography; D044943:Fatty Acid Desaturases / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D015151:Immunoblotting; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D007791:Lactoylglutathione Lyase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D018697:Nootropic Agents / Q000008:administration & dosage; D020411:Oligonucleotide Array Sequence Analysis; D010084:Oxidation-Reduction; D012895:Sleep, REM / Q000187:drug effects; D013826:Theta Rhythm
chemical_list: D005227:Fatty Acids; D018697:Nootropic Agents; D000108:Acetylcarnitine; D044943:Fatty Acid Desaturases; D042964:Acyl-CoA Dehydrogenase; D007791:Lactoylglutathione Lyase