[The formation of neurons in the bone marrow, the dream of alchemy in the new millenium].
In rodents, bone marrow contains stem cells that have the potentiality to differentiate into mesodermal and non-mesodermal cells, both in vitro and in vivo. These cells can populate a wide panel of organs such as the liver, the brain, the lungs, the heart.... They appropriately differentiate according to the environment in which they migrate and are known to assume specific functions. Even in adult animals, these cells can migrate and differentiate. Such a potentiality suggests exciting therapeutic outcomes. Brain lesions could benefit of such techniques. These experimental protocols should be precisely controlled before their use in medicine in order to solve problems that still remain such as the permeability of the hemato-encephalic barrier, the integration of differentiated grafted cells into local functional neural networks.
Khonsari
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Laboratoire d'Histologie et Embryologie, UMR CNRS 7000, Faculté de Médecine Pitié-Salpêtrière, Université Paris 6, 105, Boulevard de l'Hôpital, 75634 Paris, France.
Catala
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D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D001927:Brain Diseases / Q000628:therapy; D002454:Cell Differentiation; D009474:Neurons / Q000166:cytology*; D012377:Rodentia; D033581:Stem Cell Transplantation / Q000639:trends*; D013234:Stem Cells / Q000166:cytology*