title: Antralization at the edge of proximal gastric ulcers: does Helicobacter pylori infection play a role?
abstract: OBJECTIVE
  To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect of H. pylori eradication on the mucosal appearances.
  
  
  METHODS
  Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type. H. pylori positive patients received either triple therapy, or omeprazole.
  
  
  RESULTS
  Patients with index ulcers in the incisura, body or fundus (n=116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge in H. pylori-positive patients than H. pylori-negative patients (93 % vs 60 %, OR=8.95, 95 %CI: 2.47-32.4, P=0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93 % to 61 %, P=0.004) at the ulcer edge in patients with H. pylori being eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection.
  
  
  CONCLUSIONS
  H. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection.
authors.affiliation: Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
authors.forename: Harry Hua-Xinag
authors.initials: HH
authors.lastname: Xia
authors.forename: Shiu Kum
authors.initials: SK
authors.lastname: Lam
authors.forename: Wai Man
authors.initials: WM
authors.lastname: Wong
authors.forename: Wayne Hsing-Cheng
authors.initials: WH
authors.lastname: Hu
authors.forename: Kam Chuen
authors.initials: KC
authors.lastname: Lai
authors.forename: Sau Hing
authors.initials: SH
authors.lastname: Wong
authors.forename: Suet Yi
authors.initials: SY
authors.lastname: Leung
authors.forename: Siu Tsan
authors.initials: ST
authors.lastname: Yuen
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Wright
authors.forename: Benjamin Chun-Yu
authors.initials: BC
authors.lastname: Wong
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use; D011706:Pyloric Antrum / Q000473:pathology*; D013276:Stomach Ulcer / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology*
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D009853:Omeprazole