Regulation of peripheral T-cell homeostasis by receptor signalling.
The peripheral T-cell pool is maintained at a constant size throughout life. This is achieved through tight homeostatic regulation of the different T-cell subsets. T cells appear to be able to sense whether the T-cell compartment is full and, if it is not, they are able to respond by undergoing cell division. Recent advances have identified that both signalling through the T-cell receptor and a variety of cytokines are essential for the regulation of these responses.
Seddon
Benedict
B
Department of Molecular Immunology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK. bseddon@nimr.mrc.ac.uk
Zamoyska
Rose
R
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D006706:Homeostasis; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
D016207:Cytokines; D011948:Receptors, Antigen, T-Cell