Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease: a meta-analysis.
OBJECTIVE
The aim of this study was to investigate whether the M235T polymorphism in the angiotensinogen gene was associated with angiotensinogen levels, systolic and diastolic blood pressure, hypertension, and risk of ischemic cardiovascular disease in different ethnic populations.


RESULTS
One hundred twenty-seven studies published between January 1992 and March 2002 examining the association of angiotensinogen gene polymorphisms with the above-mentioned end points were selected. Pooled effect sizes and Mantel-Haenszel odds ratios were calculated using Review Manager. In white subjects, genotype was associated with a stepwise increase in plasma angiotensinogen levels of 5% (95% CI, 2% to 8%; P=0.0004) in MT heterozygotes and 11% (7% to 15%; P<0.00001) in TT homozygotes compared with MM individuals. Correspondingly, genotype was associated with a stepwise increase in aggregated odds ratio for hypertension of 1.08 (95% CI, 1.01 to 1.15) in MT individuals and 1.19 (1.10 to 1.30) in TT individuals in white subjects and of 1.29 (95% CI, 0.96 to 1.74) and 1.60 (1.19 to 2.15) in Asian subjects. M235T genotype did not predict systolic or diastolic blood pressure or risk of ischemic heart disease or myocardial infarction in either ethnic group.


CONCLUSIONS
Angiotensinogen M235T genotype was associated with a stepwise increase in angiotensinogen levels in white subjects and a corresponding increase in risk of hypertension in both white and Asian subjects.
Sethi
Amar Akhtar
AA
Department of Clinical Biochemistry, Herlev University Hospital, Copenhagen, Denmark. at-h@rh.dk
Nordestgaard
Børge Grønne
BG
Tybjaerg-Hansen
Anne
A
D000808:Angiotensinogen / Q000097:blood* / Q000235:genetics*; D044466:Asian People; D044383:Black People; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics*; D009203:Myocardial Infarction / Q000208:ethnology / Q000235:genetics*; D017202:Myocardial Ischemia / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D020521:Stroke / Q000208:ethnology / Q000235:genetics; D044465:White People
D000808:Angiotensinogen