Convenient synthesis of 2-benzazepines via radical cyclization.
Synthesis of 2-benzazepines was readily achieved via 7-endo radical cyclization of N-o-bromobenzylitaconamides or N-o-bromobenzylmethacrylamides which were prepared in two steps from commercially available benzaldehydes, amines, and alpha,beta-unsaturated acids.
Kamimura
Akio
A
Department of Applied Chemistry, Faculty of Engineering, Yamaguchi University, Ube 755-8611, Japan. ak10@yamaguchi-u.ac.jp
Taguchi
Yohei
Y
Omata
Yoji
Y
Hagihara
Masahiko
M