8-Chloro-cAMP-related changes on mice uteri.
Histopathological effects of cAMP analog (8-Chloro-cAMP), tamoxifen, and medroxyprogesterone, alone or combined, upon BALB/c mice uteri are reported. 8-Chloro-cAMP diminished uterine weight, but did not modify its histopathology or estral cycle significantly. Tamoxifen diminished uterine weight showing cystic hyperplasia and an estral cycle arrested at diestrus. Medroxyprogesterone increased uterine weight, caused a swelling of the endometrium and a pseudopregnancy estrus. When combined with 8-Chloro-cAMP, tamoxifen or medroxyprogesterone always had a predominant effect. We concluded that the effects of 8-Chloro-cAMP on mice uteri did not cause significant changes on its histopathology, but diminished its weight.
Actis
Andrea
A
Department of Human Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina. andrea_actis@hotmail.com
Croci
Máximo
M
Levin
Emanuel
E
Bergoc
Rosa
R
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000009:adverse effects* / Q000031:analogs & derivatives*; D000818:Animals; D004714:Endometrial Hyperplasia / Q000139:chemically induced; D004717:Endometrium / Q000187:drug effects / Q000473:pathology; D004971:Estrus / Q000187:drug effects; D005260:Female; D008525:Medroxyprogesterone / Q000009:adverse effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011555:Pseudopregnancy / Q000139:chemically induced; D013629:Tamoxifen / Q000009:adverse effects*; D014599:Uterus / Q000187:drug effects* / Q000473:pathology
D013629:Tamoxifen; D015124:8-Bromo Cyclic Adenosine Monophosphate; C044258:8-chloro-cyclic adenosine monophosphate; D008525:Medroxyprogesterone