title: Oocyte and embryo quality in patients with excessive ovarian response during in vitro fertilization treatment.
abstract: OBJECTIVE
  This study examined oocyte and embryo quality in patients having excessive ovarian responses during assisted reproduction treatment.
  
  
  METHODS
  Two hundred and seventy-eight women of age <40 years using a long protocol of pituitary downregulation in their first intracytoplasmic sperm injection cycle indicated for severe male factors were retrospectively evaluated. Those with serum estradiol concentration on the day of HCG <10,000, 10,000-20,000, and >20,000 pmol/L were classified into Group A, Group B, and Group C, respectively.
  
  
  RESULTS
  The percentage of metaphase II oocytes (85%), fertilization rate (60-66%), and distribution of blastomere number per embryo were similar among the three groups. The proportion of transferable embryos was not reduced in Group C when compared to those of Groups A and B.
  
  
  CONCLUSIONS
  Excessive ovarian response does not compromise oocyte and embryo quality in humans. Freezing of all embryos is recommended in these patients in view of associated impaired endometrial receptivity.
authors.affiliation: Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China. nghye@hkucc.hku.hk
authors.forename: Ernest Hung Yu
authors.initials: EH
authors.lastname: Ng
authors.forename: Estella Yee Lan
authors.initials: EY
authors.lastname: Lau
authors.forename: William Shu Biu
authors.initials: WS
authors.lastname: Yeung
authors.forename: Pak Chung
authors.initials: PC
authors.lastname: Ho
mesh_terms: D000328:Adult; D001757:Blastomeres / Q000502:physiology; D004624:Embryo Transfer; D004622:Embryo, Mammalian / Q000502:physiology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D008677:Metaphase; D009865:Oocytes / Q000166:cytology*; D010053:Ovary / Q000502:physiology*; D011247:Pregnancy; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods
chemical_list: D004958:Estradiol