title: XANES determination of the platinum oxidation state distribution in cancer cells treated with platinum(IV) anticancer agents.
abstract: Here we describe the use of X-ray absorption near edge spectroscopy (XANES) to provide information about the relative proportions of platinum(II) and platinum(IV) complexes by analyzing the XANES edge height. The intracellular reduction of platinum(IV) complexes in cancer cells has been observed directly, and the proportion of reduction after 2 h was found to correlate with the reduction potentials of the complexes.
authors.affiliation: Centre for Heavy Metals Research, School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Hall
authors.forename: Garry J
authors.initials: GJ
authors.lastname: Foran
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Beale
authors.forename: Trevor W
authors.initials: TW
authors.lastname: Hambley
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000378:metabolism*; D010084:Oxidation-Reduction; D010984:Platinum / Q000737:chemistry / Q000493:pharmacokinetics*; D013052:Spectrometry, X-Ray Emission; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D010984:Platinum