Cytogenetic findings in a case of dedifferentiated chondrosarcoma.
Cytogenetic analysis of a case of dedifferentiated chondrosarcoma with a malignant fibrous histiocytoma (MFH) component revealed a near-triploid karyotype with multiple copies of chromosome 7, deletion of chromosome arm 9p, and a derivative chromosome 19 [add(19p)] in each metaphase. Whereas numerical anomalies of chromosome 7 have been frequently reported in chondrosarcoma, deletion 9p and add (19p) have been observed in MFH. A putative MFH tumor suppressor gene could be present in a critical region on chromosome bands 9p21~p22.
Casorzo
Laura
L
Pathology Unit, Institute for Cancer Research and Treatment (IRCC), Candiolo, Torino, Italy. lcasorzo@mauriziano.it
Chiecchio
Laura
L
Pisacane
Alberto
A
Fumero
Sergio
S
Canavese
Federico
F
Torchio
Bruno
B
Risio
Mauro
M
D000368:Aged; D002454:Cell Differentiation; D002813:Chondrosarcoma / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D007621:Karyotyping; D019656:Loss of Heterozygosity