title: Persorption of bovine lactoferrin from the intestinal lumen into the systemic circulation via the portal vein and the mesenteric lymphatics in growing pigs.
abstract: The absorption and the transportation of intestinally administrated bovine lactoferrin (LF) were immunohistochemically and physiochemically investigated in the small intestine of growing pigs. At the apical halves of the small intestinal villi, bovine LF was absorbed by transcytosis as small vesicles through villous columnar epithelial cells. The presence of bovine LF-positive membranes of transcytotic vesicles suggests that the absorption was mediated by LF-binding factors on the epithelial cell membranes. Almost all of the absorbed bovine LF was demonstrated to be transported via the lymphatics and the portal vein into the systemic circulation. The LF-concentration in systemic circulation was significantly higher at 1 hr following intestinal administration of bovine LF. Bovine LF-positive lymphocytes also were transferred into the systemic circulation from intestine via the lymphatics and the portal vein.
authors.affiliation: Department of Life Science, Graduate School of Science and Technology, Kobe University, Kobe, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kitagawa
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Yoshizawa
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Mohammad J R
authors.initials: MJ
authors.lastname: Talukder
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Shimizu
authors.forename: Kunio
authors.initials: K
authors.lastname: Ando
authors.forename: Etsumori
authors.initials: E
authors.lastname: Harada
mesh_terms: D000818:Animals; D002417:Cattle; D007150:Immunohistochemistry; D007421:Intestine, Small / Q000378:metabolism*; D007781:Lactoferrin / Q000097:blood* / Q000378:metabolism*; D008198:Lymph Nodes / Q000502:physiology*; D008643:Mesentery / Q000502:physiology*; D011169:Portal Vein / Q000502:physiology*; D013552:Swine / Q000378:metabolism*
chemical_list: D007781:Lactoferrin