Nanocoatings onto arteries via layer-by-layer deposition: toward the in vivo repair of damaged blood vessels.
The deposition of polysaccharide-based self-assembled nanocoatings onto damaged arteries is described as a means not only to protect a damaged artery against thrombogenesis, but also to control the healing processes by incorporating biologically active components within the multilayer. As shown by confocal microscopy, the polysaccharide multilayer was retained on the artery in physiological condition and prevented platelet adhesion. Diffusion of the polysaccharides within the artery was also observed and may be used to efficiently target the vascular wall. The NO-precursor l-arginine was used a drug model and incorporated within the self-assembled layers.
Thierry
Benjamin
B
Department of Biomedical Engineering, McGill University, H3A 2B Montreal, Canada.
Winnik
Françoise M
FM
Merhi
Yahye
Y
Tabrizian
Maryam
M
D000818:Animals; D001120:Arginine / Q000008:administration & dosage / Q000627:therapeutic use; D002686:Chitin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use*; D048271:Chitosan; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D006820:Hyaluronic Acid / Q000378:metabolism / Q000627:therapeutic use*; D018613:Microscopy, Confocal; D036103:Nanotechnology / Q000379:methods; D010973:Platelet Adhesiveness / Q000187:drug effects; D013552:Swine; D014652:Vascular Diseases / Q000188:drug therapy*
D002686:Chitin; D006820:Hyaluronic Acid; D048271:Chitosan; D001120:Arginine