Hepatocellular carcinoma associated with long-term cyclophosphamide therapy for Wegener granulomatosis.
The development of hepatocellular carcinoma (HCC) requires persistent hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. The other origins are extremely rare. A 63-year-old woman was admitted to our hospital for work-up of hepatic mass. She took cyclophosphamide for Wegener granulomatosis for 21 years. Serum HBV and HCV markers were negative. A diagnosis of HCC was made by the imaging findings, and an extended left lobectomy of the liver was performed. Histologically, the tumor was diagnosed as moderately differentiated HCC. We thus considered the HCC in this case as a complication of the long-term cyclophosphamide by the absence of known causes of HCC.
Okano
Akihiro
A
Department of Gastroenterology, Tenri Hospital, Tenri, Nara.
Matsusue
Ryo
R
Takakuwa
Hiroshi
H
Nishio
Akiyoshi
A
D006528:Carcinoma, Hepatocellular / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D003520:Cyclophosphamide / Q000009:adverse effects*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy*; D006498:Hepatectomy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D008875:Middle Aged
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide