title: Phenotypic analysis of peripheral T/NK cell lymphoma: study of 408 Japanese cases with special reference to their anatomical sites.
abstract: The World Health Organization (WHO) classification of malignant lymphoma presented a list of disease entities well defined by clinical, immunological and genetic features. Therefore, the current diagnosis of peripheral T/NK-cell lymphomas (PTNKLs) essentially requires the inclusion of anatomical sites of disease and phenotypical features. We analyzed 408 Japanese cases of PTNKLs in order to clarify the relationship between anatomical sites of disease and phenotypical features and to translate the functional subsets of T and NK cells into their diagnoses for further understanding lymphomatic biology. The T/NK-cell lymphoma entities were allocated into three categories: (i) cytotoxic memory T-cell and/or NK-cell lymphoma (n = 151) consisting of extranodal NK/T-cell tumors other than mycosis fungoides (MF); (ii) non-cytotoxic memory T-cell lymphoma (n = 142) consisting of nodal and cutaneous tumors such as angioimmunoblastic T-cell lymphoma, adult T-cell lymphoma/leukemia and MF; and (iii) anaplastic lymphoma kinase positive anaplastic large cell lymphoma (n = 110) that has unique features and might be regarded as cytotoxic 'naive' T-cell lymphoma. Overall, these three categories were significantly correlated with age of onset, anatomical sites, the level of expression of cytotoxic molecules and CD45RO, and association with Epstein-Barr virus. This concept might provide a new insight enabling further understanding of the interrelationships among WHO T/NK-cell disease entities.
authors.affiliation: Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Ichimura
authors.forename: Yoshitoyo
authors.initials: Y
authors.lastname: Kagami
authors.forename: Ritsuro
authors.initials: R
authors.lastname: Suzuki
authors.forename: Masaru
authors.initials: M
authors.lastname: Kojima
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yoshino
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Koichi
authors.initials: K
authors.lastname: Koike
authors.forename: Eisei
authors.initials: E
authors.lastname: Kondo
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Taji
authors.forename: Michinori
authors.initials: M
authors.lastname: Ogura
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Morishima
authors.forename: Tadaatsu
authors.initials: T
authors.lastname: Akagi
authors.forename: Toshitada
authors.initials: T
authors.lastname: Takahashi
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D053804:Granzymes; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007124:Immunoenzyme Techniques; D016130:Immunophenotyping; D017403:In Situ Hybridization; D007694:Killer Cells, Natural / Q000473:pathology* / Q000821:virology; D016411:Lymphoma, T-Cell, Peripheral / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D008297:Male; D008565:Membrane Proteins / Q000032:analysis; D008875:Middle Aged; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D012367:RNA, Viral / Q000032:analysis; D016601:RNA-Binding Proteins / Q000032:analysis; D012697:Serine Endopeptidases / Q000032:analysis; D000074019:T-Cell Intracellular Antigen-1; D014944:World Health Organization
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D008565:Membrane Proteins; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human; C509213:GZMB protein, human; D053804:Granzymes; D012697:Serine Endopeptidases