[Myocardial infarction in the course of antiretroviral therapy with protease inhibitor].
The use of protease inhibitors (PIs) in the antiretroviral therapy (ART) of HIV-1 infection has reduced the rate of morbidity and mortality; but, unfortunately, this therapy has several side effects and a long term toxicity. Unexpected lipid abnormalities and cardiovascular complications are observed. We report a case of myocardial infarction in a young man HIV-1 positive patient without a history of metabolic disorders and cardiovascular pathologies undergoing PI treatment. The new ART without PI was not suppressive, while hypertriglyceridemia value improved by omega 3 fatty acids use. Our opinion is to continue ART with PI and to correct lipid abnormalities with the use of antidislipidemic drugs instead to change a demonstrated suppressive ART.
Buccoliero
Giovanni
G
Struttura Complessa di Malattie Infettive, Ospedale SS Annunziata, Taranto.
Lonero
Gaetano
G
Rollo
Marco Arturo
MA
Cristiano
Letizia
L
Romanelli
Chiara
C
Loperfido
Pietro
P
Chimienti
Angelo
A
Angelini
Pasquale
P
Resta
Francesco
F
D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced / Q000150:complications; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000139:chemically induced*; D014280:Triglycerides / Q000097:blood
D017320:HIV Protease Inhibitors; D014280:Triglycerides