title: Effects of tibolone on cell adhesion molecules in postmenopausal women.
abstract: OBJECTIVE
  The first step in atherosclerosis is characterized by the adherence of lymphocytes and monocytes to cell adhesion molecules expressed by endothelial cells. Therefore, we wanted to investigate the effect of tibolone on the circulating levels of various cell adhesion molecules.
  
  
  METHODS
  Thirty postmenopausal women were enrolled in a double-blind, randomized, placebo-controlled outpatient trial.
  
  
  RESULTS
  Tibolone led to a significant decrease in soluble intercellular adhesion molecule-1, soluble intercellular adhesion molecule-3, and soluble vascular cell adhesion molecule-1, but had no effect on monocyte chemotactic protein-1.
  
  
  CONCLUSIONS
  The direct favorable effects of tibolone on endothelial cells may explain the clinical benefits of this substance in terms of anti-ischemic effects and osteoporosis prevention.
authors.affiliation: Department of Obstetrics and Gynecology, University of Vienna Medical School, Austria. christian.egarter@akh-wien.ac.at
authors.forename: Christian
authors.initials: C
authors.lastname: Egarter
authors.forename: Michael
authors.initials: M
authors.lastname: Sator
authors.forename: Johannes
authors.initials: J
authors.lastname: Huber
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015815:Cell Adhesion Molecules / Q000097:blood / Q000187:drug effects*; D004311:Double-Blind Method; D020847:Estrogen Receptor Modulators / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009652:Norpregnenes / Q000494:pharmacology*; D010865:Pilot Projects; D017698:Postmenopause
chemical_list: D015815:Cell Adhesion Molecules; D020847:Estrogen Receptor Modulators; D009652:Norpregnenes; C027385:tibolone