title: Memory in pediatric patients undergoing conscious sedation for aversive medical procedures.
abstract: This study investigated preserved memory in 26 pediatric cancer patients (65% boys, 77% Caucasian, mean age = 12.5 years) undergoing midazolam-induced conscious sedation during painful medical procedures to treat hematological or oncological diseases. The sedative midazolam had a significant anterograde amnesic effect on participants' performance on a visual recognition (explicit) memory task but not on a visual perceptual facilitation (implicit) memory task. That implicit memory scores were relatively unaffected while explicit memory scores deteriorated significantly indicates that leaning occurred while participants were sedated, even when participants did not recollect the learning event. These findings, which replicate those of M. R. Polster, R. A. McCarthy, G. O'Sullivan, P. A. Gray, and G. R. Park (1993) in a study of adults, have implications for the development and treatment of conditioned anxiety reactions associated with aversive medical procedures.
authors.affiliation: Department of Psychology, University of Maryland, Baltimore County, USA. bpringle@nida.nih.gov
authors.forename: Beverly
authors.initials: B
authors.lastname: Pringle
authors.forename: Lynnda M
authors.initials: LM
authors.lastname: Dahlquist
authors.forename: Allen
authors.initials: A
authors.lastname: Eskenazi
mesh_terms: D000293:Adolescent; D000648:Amnesia, Retrograde / Q000139:chemically induced*; D018686:Anesthetics, Intravenous / Q000009:adverse effects* / Q000494:pharmacology; D002648:Child; D016292:Procedural Sedation / Q000523:psychology*; D003955:Diagnostic Tests, Routine / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D008874:Midazolam / Q000009:adverse effects* / Q000494:pharmacology; D010146:Pain / Q000517:prevention & control* / Q000523:psychology; D013315:Stress, Psychological
chemical_list: D018686:Anesthetics, Intravenous; D008874:Midazolam