title: Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents.
abstract: Novel matrix metalloproteinase (MMP) inhibitor radiotracers, (S)-3-methyl-2-(2',3',4'-methoxybiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1a-c), (S)-3-methyl-2-(2',3',4'-fluorobiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1d-f), and (S)-3-methyl-2-(4'-nitrobiphenyl-4-sulfonylamino)-butyric acid [(11)C]methyl ester (1g), a series of substituted biphenylsulfonamide derivatives, have been synthesized for evaluation as new potential positron emission tomography (PET) cancer imaging agents.
authors.affiliation: Department of Radiology, Indiana University School of Medicine, IN 46202, Indianapolis, USA.
authors.forename: Xiangshu
authors.initials: X
authors.lastname: Fei
authors.forename: Qi Huang
authors.initials: QH
authors.lastname: Zheng
authors.forename: Xuan
authors.initials: X
authors.lastname: Liu
authors.forename: Ji Quan
authors.initials: JQ
authors.lastname: Wang
authors.forename: Hui Bin
authors.initials: HB
authors.lastname: Sun
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Mock
authors.forename: K Lee
authors.initials: KL
authors.lastname: Stone
authors.forename: Kathy D
authors.initials: KD
authors.lastname: Miller
authors.forename: George W
authors.initials: GW
authors.lastname: Sledge
authors.forename: Gary D
authors.initials: GD
authors.lastname: Hutchins
mesh_terms: D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D007202:Indicators and Reagents; D007553:Isotope Labeling; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D053509:Matrix Metalloproteinase 13; D061965:Matrix Metalloproteinase Inhibitors; D008968:Molecular Conformation; D009369:Neoplasms / Q000000981:diagnostic imaging*; D011480:Protease Inhibitors / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014055:Tomography, Emission-Computed
chemical_list: D001713:Biphenyl Compounds; D007202:Indicators and Reagents; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D019275:Radiopharmaceuticals; D013449:Sulfonamides; D053509:Matrix Metalloproteinase 13