title: Role of cell-cycle regulatory proteins in gynecological cancer.
abstract: Human malignant tumors are characterized by abnormal proliferation resulting from alterations in cell-cycle regulatory mechanisms. This review summarizes the current knowledge about these aberrations in malignant tumors of the ovary, endometrium, cervix uteri, and vulva. The data indicate that analysis of single cell cycle stimulating or inhibiting proteins partly produces unexpected, apparently paradoxical results, and cell-cycle regulatory pathways should be regarded as a whole in order to identify the molecular mechanisms leading to abnormal tumor cell proliferation. For the papillomavirus (HPV)- associated cervical and vulvar carcinomas, the manifold effects of the viral oncogenes E6 and E7 on cell-cycle control are described.
authors.affiliation: Institute of Pathology, Department of Gynecopathology, University Clinics Hamburg-Eppendorf, Hamburg, Germany. milde@uke.uni-hamburg.de
authors.forename: Karin
authors.initials: K
authors.lastname: Milde-Langosch
authors.forename: Sabine
authors.initials: S
authors.lastname: Riethdorf
mesh_terms: D018797:Cell Cycle Proteins / Q000378:metabolism*; D016889:Endometrial Neoplasms / Q000503:physiopathology; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D010051:Ovarian Neoplasms / Q000503:physiopathology; D002583:Uterine Cervical Neoplasms / Q000503:physiopathology; D014846:Vulvar Neoplasms / Q000503:physiopathology
chemical_list: D018797:Cell Cycle Proteins