Coexistence of two distinct secretion mutations (P5T and I97L) in hepatitis B virus core produces a wild-type pattern of secretion.
Unlike a Tokyo isolate of hepatitis B virus variants, we found a Shanghai isolate that secretes few virions with an immature genome despite its core I97L mutation. Core mutations P5T and I97L were found to be mutually compensatory in offsetting their respective distinct effects on virion secretion.
Chua
Pong Kian
PK
Center for Tropical Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555-0609, USA.
Wen
Yu-Mei
YM
Shih
Chiaho
C
D001483:Base Sequence; D002460:Cell Line; D017931:DNA Primers; D006512:Hepatitis B Core Antigens / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006515:Hepatitis B virus / Q000276:immunology / Q000502:physiology; D006801:Humans; D009154:Mutation
D017931:DNA Primers; D006512:Hepatitis B Core Antigens