title: Selective occlusion of subfoveal choroidal neovascularization in angioid streaks by using a new technique of ingrowth site treatment.
abstract: OBJECTIVE
  To evaluate the visual and angiographic effects, as well as optical coherence tomography (OCT) findings, after a new treatment-neovascular ingrowth-site photothrombosis-in patients with subfoveal choroidal neovascularization (CNV) secondary to angioid streaks.
  
  
  METHODS
  Prospective noncomparative small case series.
  
  
  METHODS
  Five eyes of 5 patients with angioid streaks in whom fluorescein and conventional indocyanine green (ICG) angiography clearly demonstrated distinct CNV vessels supplying the subfoveal neovascular complex.
  
  
  METHODS
  All five eyes were submitted to ICG-mediated photothrombosis of the neovascular ingrowth site. This novel, laser/dye-mediated technique uses large-spot, lower-intensity 810-nm light for continuous application of laser energy to ICG concentrated in vascular lesions.
  
  
  METHODS
  Visual outcome and the results of fluorescein angiography, ICG angiography, and OCT evaluation.
  
  
  RESULTS
  Fluorescein and conventional ICG angiography were sufficient to identify the CNV ingrowth site, which was juxtafoveal in 2 and extrafoveal in 3 of the 5 eyes in this series. Obliteration of the entire neovascular lesion was achieved in all patients within the first hour after ICG-mediated photothrombosis of the CNV ingrowth site. At 1 week, the mean change in best-corrected visual acuity from baseline was +3.2 (+/-1.4) lines. Twelve months after treatment, visual acuity improved by 3 or more lines in all patients, and decreased leakage of fluorescein from the CNV, as well as OCT evidence of reduced or resolved retinal edema, was seen at the last follow-up visit. Major complications, such as immediate severe visual loss and retinal vessel occlusion in the early posttreatment period, were not identified in the 5 patients submitted to the procedure.
  
  
  CONCLUSIONS
  Photothrombosis of the CNV ingrowth site by using lower-intensity light to direct laser energy continuously after IV ICG infusion is a safe and effective technique for rapid induction of CNV hypoperfusion in selected patients and is associated with considerable improvement in visual acuity and partial restoration of the retinal architecture up to 12 months after treatment.
authors.affiliation: Instituto da Visão-IPEPO, Department of Ophthalmology, Federal University of São Paulo, Brazil. roger.retina@globo.com
authors.forename: Rogério A
authors.initials: RA
authors.lastname: Costa
authors.forename: Daniela
authors.initials: D
authors.lastname: Calucci
authors.forename: José A
authors.initials: JA
authors.lastname: Cardillo
authors.forename: Michel E
authors.initials: ME
authors.lastname: Farah
mesh_terms: D000368:Aged; D000793:Angioid Streaks / Q000150:complications*; D020256:Choroidal Neovascularization / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D004396:Coloring Agents / Q000627:therapeutic use*; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000098:blood supply*; D006801:Humans; D007208:Indocyanine Green / Q000627:therapeutic use*; D007368:Interferometry; D008027:Light; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D011446:Prospective Studies; D012449:Safety; D013927:Thrombosis / Q000209:etiology*; D014054:Tomography; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green