Evidence of human immunodeficiency virus-associated lipodystrophy syndrome in children treated with protease inhibitors.
We conducted a prospective evaluation for evidence of the HIV-associated lipodystrophy syndrome of 26 children infected with HIV-1. Six children had evidence of body fat redistribution. Nine children showed laboratory evidence of insulin resistance. All children with body fat distribution or insulin resistance had been treated with protease inhibitors. Children treated with protease inhibitors had higher total cholesterol, higher low density lipoprotein-cholesterol and higher triglycerides than untreated children.
Bockhorst
James L
JL
Department of Medicine, Baystate Medical Center, 759 Chestnut Street, Springfield, MA 01199, USA.
Ksseiry
Iyad
I
Toye
Maripat
M
Chipkin
Stuart R
SR
Stechenberg
Barbara W
BW
Fisher
Donna J
DJ
Allen
Holley F
HF
D000293:Adolescent; D000704:Analysis of Variance; D001823:Body Composition; D015992:Body Mass Index; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D015497:HIV-1 / Q000187:drug effects* / Q000302:isolation & purification; D039682:HIV-Associated Lipodystrophy Syndrome / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D008075:Lipoproteins, HDL / Q000032:analysis / Q000187:drug effects; D008297:Male; D011336:Probability; D011379:Prognosis; D011446:Prospective Studies; D011480:Protease Inhibitors / Q000008:administration & dosage*; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome
D008075:Lipoproteins, HDL; D011480:Protease Inhibitors