Endoscopic full-thickness plication: the device, technique, pre-clinical and early clinical experience.
The endoscopic full-thickness plication device is designed to inhibit reflux with a single plication near the gastroesophageal junction. Full-thickness plication of the proximal stomach may improve the competency of the gastroesophageal barrier by restoring the valvular mechanism of the gastroesophageal junction. Other potential mechanisms include alteration of the angle of His, and reduction of the compliance of the gastric cardia and fundus. The procedure is easily and safely performed and, in the human pilot study, has been shown to reduce symptoms and medication use associated with gastroesophageal reflux disease.
Chuttani
Ram
R
Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA. rchuttan@caregroup.harvard.edu
D000818:Animals; D002986:Clinical Trials as Topic; D019723:Endoscopes; D004943:Esophagogastric Junction / Q000601:surgery; D018662:Fundoplication / Q000379:methods; D005753:Gastric Mucosa / Q000473:pathology / Q000601:surgery; D005764:Gastroesophageal Reflux / Q000601:surgery*; D015391:Gastroplasty / Q000295:instrumentation / Q000379:methods; D005773:Gastroscopy / Q000379:methods; D006801:Humans; D013536:Suture Techniques / Q000295:instrumentation*; D013552:Swine