title: Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria.
abstract: Gender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.
authors.affiliation: Centre for Medical Parasitology, Copenhagen University Hospital (Rigshospitalet) and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Anja T R
authors.initials: AT
authors.lastname: Jensen
authors.forename: Hanne D
authors.initials: HD
authors.lastname: Zornig
authors.forename: Caecilie
authors.initials: C
authors.lastname: Buhmann
authors.forename: Ali
authors.initials: A
authors.lastname: Salanti
authors.forename: Kwadwo A
authors.initials: KA
authors.lastname: Koram
authors.forename: Eleanor M
authors.initials: EM
authors.lastname: Riley
authors.forename: Thor G
authors.initials: TG
authors.lastname: Theander
authors.forename: Lars
authors.initials: L
authors.lastname: Hviid
authors.forename: Trine
authors.initials: T
authors.lastname: Staalsoe
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D002809:Chondroitin Sulfates / Q000502:physiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016778:Malaria, Falciparum / Q000276:immunology*; D008297:Male; D010298:Parity; D010963:Plasmodium falciparum / Q000235:genetics / Q000276:immunology*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000276:immunology*; D015800:Protozoan Proteins / Q000235:genetics*; D012737:Sex Factors
chemical_list: D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D015800:Protozoan Proteins; C085731:erythrocyte membrane protein 1, Plasmodium falciparum; D002809:Chondroitin Sulfates