Novel soraphens from precursor directed biosynthesis.
Six novel halogenated soraphen analogues have been isolated from the wild-type producing organism using precursor directed biosyntheses; the best 'delivery vehicle' for the novel starter acids was cinnamate but ortho substituents were not tolerated by the soraphen PKS.
Hill
Alison M
AM
Department of Chemistry, King's College London, Strand, London, UK WC2R 2LS. a.m.hill@ex.ac.uk
Thompson
Betty L
BL
D000935:Antifungal Agents / Q000096:biosynthesis; D001565:Benzoates / Q000737:chemistry; D002934:Cinnamates / Q000737:chemistry; D003066:Coenzyme A Ligases / Q000378:metabolism; D006219:Halogens / Q000737:chemistry; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009097:Multienzyme Complexes / Q000378:metabolism; D009231:Myxococcales / Q000254:growth & development / Q000378:metabolism*; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000378:metabolism*; D010135:p-Fluorophenylalanine
D000935:Antifungal Agents; D001565:Benzoates; D002934:Cinnamates; D006219:Halogens; D018942:Macrolides; D009097:Multienzyme Complexes; C086151:soraphen A; D010649:Phenylalanine; D010135:p-Fluorophenylalanine; D003066:Coenzyme A Ligases; C055455:benzoate coenzyme A ligase