title: Macular atrophy after photocoagulation of soft drusen.
abstract: OBJECTIVE
  To analyze the appearance and characteristics of macular atrophy after photocoagulation of soft drusen.
  
  
  METHODS
  The authors studied the development of macular atrophy in 52 consecutive eyes (52 patients) that underwent green argon laser photocoagulation for the treatment of soft drusen. The mean age was 71.4 +/- 5.1 years (range, 61-85 years). Twelve eyes (23%) were in men and 40 (77%) were in women. Follow-up averaged 50.1 +/- 21.3 months (range, 6-96 months).
  
  
  RESULTS
  Macular atrophy occurred in nine eyes (17.7%), including five (56%) women and four (44%) men. The time interval between photocoagulation and macular atrophy averaged 37.2 +/- 21.2 months (range, 7-75 months). The mean age of patients with macular atrophy was 68.1 +/- 4.6 years (range, 61-75 years). Mean best-corrected visual acuity (BCVA) after soft drusen photocoagulation and before macular atrophy development was 20/55 (range, 20/28-20/200). After the appearance of macular atrophy, mean BCVA was 20/126 (range, 20/50-20/900). Differences between BCVA before and after macular atrophy were statistically significant (P = 0.02, student's paired t-test).
  
  
  CONCLUSIONS
  Macular atrophy can occur after photocoagulation of soft drusen, as applied according to our treatment protocol. The development of macular atrophy was associated with a significant decrease in BCVA.
authors.affiliation: Department of Ophthalmology, Miguel Hernández University School of Medicine, and Instituto Oftalmológico de Alicante, Spain. jm.ruiz@umh.es
authors.forename: José
authors.initials: J
authors.lastname: Ruiz-Moreno
authors.forename: Concepción
authors.initials: C
authors.lastname: De la Vega
authors.forename: Marco A
authors.initials: MA
authors.lastname: Zarbin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D017075:Laser Coagulation / Q000009:adverse effects*; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D015593:Retinal Drusen / Q000601:surgery*; D013997:Time Factors; D014792:Visual Acuity