[Solid phase synthesis and chromatographic characteristics of nucleophilic agents conjugated with oligonucleotides containing 5'-terminal carboxyl group].
Conjugates of amines or short peptides with oligonucleotides containing 5'-terminal carboxyl group were prepared by solid phase chemical synthesis. A correlation between the physicochemical parameters and retention times of the synthesized conjugates was established by ion-pair reversed-phase HPLC.
Kachalova
A V
AV
Faculty of Chemistry, Belozersky Institute of Physicochemical Biology, Lomonosov State University, Vorob'evy gory, Moscow, 119992 Russia.
Tashlitskiĭ
V N
VN
Stetsenko
D A
DA
Romanova
E A
EA
Gait
M J
MJ
Oretskaia
T S
TS
D000588:Amines / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D002245:Carbon Dioxide / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry
D000588:Amines; D000596:Amino Acids; D002264:Carboxylic Acids; D009841:Oligonucleotides; D010455:Peptides; D002245:Carbon Dioxide; C041069:carboxyl radical