title: [Case report: difficulty in treating one event of Streptococcus pneumoniae meningitis].
abstract: Streptococcus pneumoniae is one of the leading causes of acute bacterial meningitis and the emergence of antibiotic resistant pneumococci is an increasing problem worldwide. In this report, a 22-years-old woman was presented with pneumococcal meningitis occurring twice in a 5 months period. After the first meningitis attack, the patient had been vaccinated by 23-valent polysaccharide vaccine but the illness has relapsed. Although S. pneumoniae which was isolated from the patient has been found intermediate resistant to penicillin and susceptible to ceftriaxone by E-test, the patient could be treated only with meropenem. The case has been presented and discussed for ceftriaxone failure in spite of in-vitro susceptibility. On the other hand, this case indicated that vaccination might fail to prevent recurrence.
authors.affiliation: Gazi Universitesi Tip Fakültesi, Klinik Bakteriyoloji ve Enfeksiyon Hastaliklari Anabilim Dali, Ankara.
authors.forename: Kenan
authors.initials: K
authors.lastname: Hizel
authors.forename: Ozlem
authors.initials: O
authors.lastname: Güzel
authors.forename: Arzu
authors.initials: A
authors.lastname: Altunçekiç
authors.forename: Deniz
authors.initials: D
authors.lastname: Gür
authors.forename: Dilek
authors.initials: D
authors.lastname: Arman
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology; D005260:Female; D006801:Humans; D016233:Immunotherapy, Active / Q000592:standards; D008586:Meningitis, Pneumococcal / Q000188:drug therapy / Q000517:prevention & control / Q000628:therapy*; D000077731:Meropenem; D010406:Penicillins / Q000494:pharmacology; D022242:Pneumococcal Vaccines / Q000627:therapeutic use*; D055502:Secondary Prevention; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000276:immunology; D013845:Thienamycins / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D022242:Pneumococcal Vaccines; D013845:Thienamycins; D002443:Ceftriaxone; D000077731:Meropenem