title: Calcium phosphate coating of nickel-titanium shape-memory alloys. Coating procedure and adherence of leukocytes and platelets.
abstract: Nickel-titanium shape-memory alloys (NiTi-SMA) were coated with calcium phosphate by dipping in oversaturated calcium phosphate solution. The layer thickness (typically 5-20 micrometer) can be varied by choice of the immersion time. The porous nature of the layer of microcrystals makes it mechanically stable enough to withstand both the shape-memory transition upon cooling and heating and also strong bending of the material (superelastic effect). This layer may improve the biocompatibility of NiTi-SMA, particulary for osteosynthetic devices by creating a more physiological surface and by restricting a potential nickel release. The adherence of human leukocytes (peripheral blood mononuclear cells and polymorphonuclear neutrophil granulocytes) and platelets to the calcium phosphate layer was analyzed in vitro. In comparison to non-coated NiTi-SMA, leukocytes and platelets showed a significantly increased adhesion to the coated NiTi-SMA.
authors.affiliation: Solid State Chemistry, Faculty of Chemistry, University of Bochum, Universitaetsstr. 150, D-44780, Bochum, Germany.
authors.forename: Jongsik
authors.initials: J
authors.lastname: Choi
authors.forename: Denise
authors.initials: D
authors.lastname: Bogdanski
authors.forename: Manfred
authors.initials: M
authors.lastname: Köller
authors.forename: Stefan A
authors.initials: SA
authors.lastname: Esenwein
authors.forename: Dietmar
authors.initials: D
authors.lastname: Müller
authors.forename: Gert
authors.initials: G
authors.lastname: Muhr
authors.forename: Matthias
authors.initials: M
authors.lastname: Epple
mesh_terms: D000497:Alloys; D001672:Biocompatible Materials / Q000737:chemistry*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002130:Calcium Phosphates / Q000737:chemistry*; D002448:Cell Adhesion; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008422:Materials Testing; D009532:Nickel / Q000737:chemistry*; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D002130:Calcium Phosphates; D009532:Nickel; D014025:Titanium