Lipoprotein(a) and cardiovascular risk factors in a cohort of 6-year-old children. The Rivas-Vaciamadrid Study.
We have studied the distribution of lipoprotein(a) (Lp(a)) and its relation to lipid profiles and a family history of cardiovascular disease in grandparents in a cohort of 673 6-year-old Spanish children. Lp(a) levels were highly skewed, showed no differences between sexes and had no relevant relations with anthropometric variables. When compared with children without a family history of stroke, children with a family history of this disorder showed significantly higher levels of Lp(a) (median 13 mg/dl, range 2-110 mg/dl versus 9 mg/dl, range 2-120 mg/dl, P=0.02). Also the percentage of children with a family history of stroke was higher in the group of children with Lp(a) levels above 30 mg/dl than in the group who exhibited lower levels (20.9% versus 10.4%, P=0.002). Children with a family history of coronary heart disease had higher levels of Lp(a) than children without such history (median 14 mg/dl, range 2-120 mg/dl versus 8 mg/dl, range 2-62 mg/dl, P=0.03). Finally, when compared with children with Lp(a) levels <30 mg/dl, those with Lp(a) levels above 30 mg/dl showed significantly higher mean levels of total cholesterol (174.9 versus 169.4 mg/dl, P<0.05), low-density lipoprotein-cholesterol (109.1 versus 102.4 mg/dl, P<0.05), and apolipoprotein B (81.9 versus 74.6 mg/dl, P<0.05).


CONCLUSIONS
Our study shows the existence of an association between high levels of lipoprotein (a) in 6 year-old children and a family history of both cerebrovascular and coronary disease in grandparents. High levels of lipoprotein (a) were also associated with high levels of low-density lipoprotein-cholesterol and apolipoprotein B.
Gonzalez-Requejo
Angel
A
Primary Care Centre Rivas, Rivas-Vaciamadrid, Spain. angelgrequejo@terra.es
Sanchez-Bayle
Marciano
M
Ruiz-Jarabo
Consuelo
C
Asensio-Anton
Juliana
J
Pelaez
Maria Jesus
MJ
Morales
Maria Teresa
MT
Anton-Pacheco
Epifania
E
Fernandez-Calle
Margarita
M
Madera-Cruz
Elsa
E
D000886:Anthropometry; D001055:Apolipoproteins B / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology*; D002648:Child; D002669:Child Welfare; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology; D005192:Family Health; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000378:metabolism*; D008297:Male; D015588:Observer Variation; D015995:Prevalence; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D013223:Statistics as Topic; D020521:Stroke / Q000097:blood / Q000453:epidemiology
D001055:Apolipoproteins B; D015415:Biomarkers; D008078:Cholesterol, LDL; D017270:Lipoprotein(a)