title: Large-dose hydroxyethyl starch 130/0.4 does not increase blood loss and transfusion requirements in coronary artery bypass surgery compared with hydroxyethyl starch 200/0.5 at recommended doses.
abstract: BACKGROUND
  Hydroxyethyl starch (HES) 130/0.4 may impair blood coagulation less than other HES solutions and, thus, may be used at larger doses without increasing the risk of postoperative bleeding. This study tested the hypothesis that volume replacement with 6% HES 130/0.4 at a dose of up to 50 ml/kg does not increase blood loss and transfusion requirements in elective coronary artery bypass surgery compared with 6% HES 200/0.5 at a dose of up to 33 ml/kg.
  
  
  METHODS
  One hundred twenty adult patients scheduled for elective coronary artery bypass surgery were randomized to receive up to 50 ml/kg of 6% HES 130/0.4 or up to 33 ml/kg of 6% HES 200/0.5 for volume replacement during surgery and until 24 h thereafter. Volume requirements in excess of the respective maximum dose of HES were treated with gelatin. Colloid use was at the discretion of the attending physicians and not dictated by protocol. The primary outcome variable was chest tube drainage volume during the first 24 h after surgery.
  
  
  RESULTS
  The data from 117 patients (HES 130/0.4, 59 patients; HES 200/0.5, 58 patients) who completed the study according to protocol were analyzed. The median volumes of HES administered were 49 and 33 ml/kg in the HES 130/0.4 and HES 200/0.5 groups, respectively (P < 0.001). Consequently, patients in the HES 130/0.4 group required less gelatin in addition to HES than those in the HES 200/0.5 group (medians: 7 ml/kg vs. 20 ml/kg, P < 0.001). The combined volumes of HES and gelatin were similar for both groups (P = 0.21). The 24-h chest tube drainage (medians: 660 ml vs. 705 ml, P = 0.60) did not differ significantly between the groups, nor did transfusion outcome.
  
  
  CONCLUSIONS
  Six percent HES 130/0.4 at a median dose of 49 ml/kg did not increase blood loss and transfusion requirements in coronary artery bypass surgery compared with 6% HES 200/0.5 at a median dose of 33 ml/kg.
authors.affiliation: Department of Anesthesiology, University of Cologne, Germany. stefan-mario.kasper@medizin.uni-koeln.de
authors.forename: Stefan-Mario
authors.initials: SM
authors.lastname: Kasper
authors.forename: Philipp
authors.initials: P
authors.lastname: Meinert
authors.forename: Sandra
authors.initials: S
authors.lastname: Kampe
authors.forename: Christoph
authors.initials: C
authors.lastname: Görg
authors.forename: Christof
authors.initials: C
authors.lastname: Geisen
authors.forename: Uwe
authors.initials: U
authors.lastname: Mehlhorn
authors.forename: Christoph
authors.initials: C
authors.lastname: Diefenbach
mesh_terms: D000368:Aged; D001780:Blood Coagulation Tests; D016063:Blood Loss, Surgical / Q000503:physiopathology*; D001803:Blood Transfusion; D001026:Coronary Artery Bypass; D017707:Erythrocyte Transfusion; D005260:Female; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes