Female-specific reproductive toxicities following preconception exposure to xenobiotics.
Females do differ from males in their germ cell and general reproductive responses to toxicants. Chromatin structure is perhaps one factor that contributes to sex differences in germ cell response to toxicants. Differences in available targets likely contribute to response differences between sexes as well as to within sex differences between germ cell stages. It is important to consider these differences when conducting reproductive toxicity studies and interpreting the results.
Bishop
Jack B
JB
NIEHS, Laboratory of Toxicology, 111 TW Alexander Dr., Research Triangle Park, NC 27709, USA. bishop@niehs.nih.gov
D000014:Abnormalities, Drug-Induced; D000818:Animals; D005260:Female; D005799:Genes, Dominant; D005854:Germ Cells / Q000187:drug effects; D008297:Male; D018811:Maternal Exposure; D016296:Mutagenesis; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D013723:Teratogens / Q000633:toxicity; D013997:Time Factors; D015262:Xenobiotics / Q000633:toxicity*
D013723:Teratogens; D015262:Xenobiotics