title: Transient hypohidrosis induced by topiramate.
abstract: OBJECTIVE
  Hypohidrosis during topiramate (TPM) treatment was recently reported in children. We describe an adult epilepsy patient who developed inability to sweat as well as heat intolerance while undergoing treatment with TPM.
  
  
  METHODS
  To detect the site of the sweat block, patient underwent examination of sweat gland function, cardiovascular autonomic test, and body temperature rhythm determination.
  
  
  RESULTS
  During TPM treatment, cardiovascular autonomic function and circadian rhythm of body core temperature were normal, whereas thermoregulatory sweat test (TST) showed anhydrosis. This adverse drug effect was quickly resolved after drug discontinuation.
  
  
  CONCLUSIONS
  Because of normal cardiovascular autonomic function and central and peripheral thermoregulatory mechanisms, we hypothesize that hypohidrosis during TPM treatment could be due to a carbonic anhydrases (CA) block at the level of sweat gland.
authors.affiliation: Department of Neurological Sciences, University of Bologna, Bologna, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: de Carolis
authors.forename: Fabiola
authors.initials: F
authors.lastname: Magnifico
authors.forename: Giulia
authors.initials: G
authors.lastname: Pierangeli
authors.forename: Rita
authors.initials: R
authors.lastname: Rinaldi
authors.forename: Massimo
authors.initials: M
authors.lastname: Galeotti
authors.forename: Sabina
authors.initials: S
authors.lastname: Cevoli
authors.forename: Pietro
authors.initials: P
authors.lastname: Cortelli
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D001833:Body Temperature Regulation / Q000187:drug effects; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004828:Epilepsies, Partial / Q000188:drug therapy*; D017029:Epilepsy, Complex Partial / Q000188:drug therapy*; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D006359:Heat Exhaustion / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007007:Hypohidrosis / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D013546:Sweating / Q000187:drug effects; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D002257:Carbonic Anhydrase Inhibitors; D000077236:Topiramate; D005632:Fructose