Combination effects of cephalexin and gentamicin on Edwardsiella tarda and Streptococcus iniae.
The objective of this study was to determine the in vitro activity of cephalexin-gentamicin combination by a microbroth chequerboard technique against clinical isolates of Edwardsiella tarda and Streptococcus iniae. Gentamicin was shown more susceptible than cephalexin against both bacteria. The effect of cephalexin-gentamicin combination against both bacteria represented additive interaction. The combination even showed synergic interaction (22%) against E. tarda, with a FIC index of <0.5 as a borderline. No antagonism for cephalexin-gentamicin combination was observed for any bacterial strain.
Lim
Jong-Hwan
JH
Division of Veterinary Pharmacology and Toxicology, Chungnam National University, 220 Gung-dong, Yuseong-Gu, Daejeon, South Korea.
Hwang
Youn-Hwan
YH
Park
Byung-Kwon
BK
Yun
Hyo-in
HI
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002506:Cephalexin / Q000008:administration & dosage*; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D020609:Edwardsiella tarda / Q000187:drug effects* / Q000302:isolation & purification; D005399:Fishes / Q000382:microbiology; D005839:Gentamicins / Q000008:administration & dosage*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D013291:Streptococcus / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002506:Cephalexin