Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients.
Platelets, like neurons, contain 120- to 130- and 110-kd amyloid precursor proteins (APPs). Their ratio is reduced in AD, further reductions correlating with reduced Mini-Mental Status Examination scores [r(11) = 0.69, p < 0.05]. As statins alter APP processing, platelet APPs were analyzed in patients with AD given anticholesterol drugs for 6 weeks. APP ratios increased [t(37) = -3.888, p = 0.0004], proportionally with reduced cholesterol [r(36) = -0.45, p = 0.005]. Longer trials may reveal slowed cognitive loss, validating this index.
Baskin
F
F
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, TX 75390-9036, USA. Fred.Baskin@UTSouthwestern.edu
Rosenberg
R N
RN
Fang
X
X
Hynan
L S
LS
Moore
C B
CB
Weiner
M
M
Vega
G L
GL
D000544:Alzheimer Disease / Q000097:blood* / Q000188:drug therapy; D016229:Amyloid beta-Peptides / Q000097:blood*; D016564:Amyloid beta-Protein Precursor / Q000097:blood*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D008148:Lovastatin / Q000494:pharmacology* / Q000627:therapeutic use; D009525:Niacin / Q000494:pharmacology / Q000627:therapeutic use; D017035:Pravastatin / Q000494:pharmacology* / Q000627:therapeutic use; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D019821:Simvastatin / Q000494:pharmacology* / Q000627:therapeutic use; D016037:Single-Blind Method
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D009525:Niacin; D002784:Cholesterol; D008148:Lovastatin; D019821:Simvastatin; D017035:Pravastatin