Cobalt-mediated approach for the synthesis of terpene-based hybrids.
[structure: see text] Dicobalt-beta-pinene hybrids of types I and II have been prepared using a Nicholas reaction between propargyl derivatives, obtained from commercial (1R)-(-)-myrtenal, and different aromatic nucleophiles. The method is suitable for the preparation of densely functionalized bio-organometallic natural product-based hybrids, as demonstrated by the preparation of a beta-pinene-neoclerodane hybrid.
Alvaro
Elsa
E
Instituto de Química Orgánica, Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, 28006-Madrid, Spain.
de la Torre
María C
MC
Sierra
Miguel A
MA