title: Cyclocarbopalladation: 5-exo-dig cyclization versus direct Stille cross-coupling reaction. The influence of the alpha,beta-propargylic substitution.
abstract: Several bicyclic compounds bearing a 1,2-cyclopentanediol have been prepared from various anti- or syn-gamma-bromopropargylic diols and cis-dioxolanes under palladium(0) catalysis. The reaction proceeds through a 5-exo-dig cyclocarbopalladation. When the corresponding trans-dioxolanes are used, the only products isolated are obtained from a direct Stille cross-coupling reaction. [reaction: see text]
authors.affiliation: Faculté de Pharmacie, Université Louis Pasteur de Strasbourg (UMR 7081 CNRS/ULP), 74 route du Rhin, 67401 Illkirch-Cedex, France.
authors.forename: Bahaâ
authors.initials: B
authors.lastname: Salem
authors.forename: Estelle
authors.initials: E
authors.lastname: Delort
authors.forename: Philippe
authors.initials: P
authors.lastname: Klotz
authors.forename: Jean
authors.initials: J
authors.lastname: Suffert