Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats.
Neonatally streptozotocin-induced diabetic (n-STZ) rats were given food containing Lactobacillus GG cells (GG) or a control diet (control), from 9 to 18 weeks of age. The GG cells significantly lowered the blood hemoglobin A(1C) (HbA(1C)) level and improved glucose tolerance in n-STZ rats (p<0.05). In the GG group, the serum insulin level at 30 min after glucose loading was significantly higher than in the control group (p<0.05).
Tabuchi
Mihoko
M
Yonezawa Women's College of Yamagata Prefecture, Yonezawa 992-0025, Japan. tabuchi@yone.ac.jp
Ozaki
Miyo
M
Tamura
Asako
A
Yamada
Noriko
N
Ishida
Tetsuo
T
Hosoda
Masataka
M
Hosono
Akiyoshi
A
D000818:Animals; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental / Q000178:diet therapy*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007778:Lactobacillus; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D013311:Streptozocin