title: Effect of hydrotalcite-like compounds on the aqueous solubility of some poorly water-soluble drugs.
abstract: A new approach of improving drug dissolution properties is described. This method exploits the property of a carrier owing to the hydrotalcite-type anionic clays (HTlc). HTlc is an inorganic layered solid that lodges anionic compounds among its layers. As HTlc dissolves at acidic pH values (pH < 4), the anions intercalated among the layers are promptly released in the medium. In this article some nonsteroidal antiinflammatory drugs were chosen as models of poorly water-soluble drugs. They were intercalated in HTlc and solubility measurements in acidic medium were performed. A remarkable improvement of drug solubility was observed especially in the case of indomethacin.
authors.affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, via del Liceo 1, University of Perugia, 06123 Perugia, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Ambrogi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Fardella
authors.forename: Giuliano
authors.initials: G
authors.lastname: Grandolini
authors.forename: Morena
authors.initials: M
authors.lastname: Nocchetti
authors.forename: Luana
authors.initials: L
authors.lastname: Perioli
mesh_terms: D000536:Aluminum Hydroxide / Q000032:analysis* / Q000737:chemistry; D008276:Magnesium Hydroxide / Q000032:analysis* / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry; D012995:Solubility / Q000187:drug effects; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013818:Thermogravimetry / Q000379:methods; D014867:Water / Q000032:analysis* / Q000737:chemistry
chemical_list: D004364:Pharmaceutical Preparations; D014867:Water; C010467:hydrotalcite; D000536:Aluminum Hydroxide; D008276:Magnesium Hydroxide