Novel alternative methods for the delivery of drugs for the treatment of asthma.
Successful delivery of dry powder aerosols to the lung requires careful consideration of the powder production process, formulation and inhaler device. Newer production methods are emerging to prepare powders with desirable characteristics for inhalational administration. The conventional formulation approach of adding coarse lactose carriers to the drug to form binary powder systems to enhance powder flow and dispersion properties has been expanded to using finer carrier particles and hydrophobic materials, as well as ternary systems. Particle morphology and surface properties have also been explored to enhance powder performance. For the inhaler device, the new generation inhalers are designed to reduce or completely decouple the influence of air flow on the aerosol generation. Each of these determinants for powder aerosol delivery is reviewed with a strong focus on the patent literature that contains enormous information about the latest development in this field.
Chan
Hak Kim
HK
Faculty of Pharmacy, A15, University of Sydney, Sydney NSW 2006, Australia. kimc@pharm.usyd.edu.au
Chew
Nora Y K
NY
D000280:Administration, Inhalation; D000336:Aerosols; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy*; D002626:Chemistry, Pharmaceutical; D004864:Equipment and Supplies; D006801:Humans; D009330:Nebulizers and Vaporizers; D011208:Powders; D012997:Solvents; D013678:Technology, Pharmaceutical
D000336:Aerosols; D018927:Anti-Asthmatic Agents; D011208:Powders; D012997:Solvents