Analysis of pancreatic polypeptide cDNA from the house musk shrew, Suncus murinus, suggests a phylogenetically closer relationship with humans than for other small laboratory animal species.
Pancreatic polypeptide was isolated and sequenced from endocrine cells of the pancreas from an insectivore, the house musk shrew, Suncus murinus. The primary sequence was APLEPAYPGD(10)NATPEQMAQY(20)AAELRKYINM(30)VTRPRYamide. This is the first polypeptide hormone to be characterised from this species and is typical of the primary sequences of pancreatic polypeptide of other animals, being a C-terminal-amidated peptide with 36 residues. Comparison with several vertebrate sequences shows that it has more in common with the human form than do the forms from common laboratory animals such as rabbits, rats, mice and guinea-pigs.
Hoyle
C H V
CH
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.
Hill
J
J
Sanger
G J
GJ
Andrews
P L R
PL
D000595:Amino Acid Sequence; D000818:Animals; D000830:Animals, Laboratory / Q000145:classification / Q000235:genetics*; D001483:Base Sequence; D018076:DNA, Complementary; D006801:Humans; D008969:Molecular Sequence Data; D010191:Pancreatic Polypeptide / Q000737:chemistry / Q000235:genetics*; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D012788:Shrews / Q000145:classification / Q000235:genetics*
D018076:DNA, Complementary; D010191:Pancreatic Polypeptide