title: Secular trends in neonatal macrosomia in Berlin: influences of potential determinants.
abstract: To investigate the trend in the prevalence of neonatal macrosomia and to evaluate the influences of potential determinants, key features of 206 308 hospital deliveries (97% of all) in Berlin in the years 1993-99, collected by the Berlin Medical Board, were analysed using SPSS 10.0. After exclusion of multiple births and preterm infants, there was a significant increase over 7 years (P < 0.01) in the prevalence of birthweights >or= 4000 g, maternal age >or= 30 years, height of >or= 165 cm, prepregnancy BMI (body mass index) >or= 26 kg/m2 and pregnancy weight gain> 16 kg, but no substantial trend in the prevalence of recognised diabetes or maternal smoking. The adjusted model (OR [95% CI]) for delivering a newborn >or= 4000 g was statistically significant for post-term delivery (2.56 [2.39, 2.75]), women aged >or= 30 years (1.06 [1.02-1.11]), >or= 165 cm tall (1.94 [1.87,2.01]), multiparae (1.98 [1.91, 2.05]), not smoking in pregnancy (2.03 [1.93, 2.14]), prepregnancy BMI >or= 26 compared with < 20 (4.01 [3.77, 4.26]), pregnancy weight gain >or= 16 kg compared with < 10 kg (3.37.[3.22, 3.53]) and for recognised diabetes (1.85.[1.69, 2.04]). It is speculated that this increase in the prevalence of neonatal macrosomia may contribute to the secular trend of overweight and obesity under affluent living conditions.
authors.affiliation: Department of Obstetrics, Charité Virchow Hospitals of the Humboldt University, Berlin, and Robert-Koch-Institute, Berlin, Germany. renate.bergmann@charite.de
authors.forename: Renate L
authors.initials: RL
authors.lastname: Bergmann
authors.forename: Rolf
authors.initials: R
authors.lastname: Richter
authors.forename: Karl E
authors.initials: KE
authors.lastname: Bergmann
authors.forename: A
authors.initials: A
authors.lastname: Plagemann
authors.forename: M
authors.initials: M
authors.lastname: Brauer
authors.forename: Joachim W
authors.initials: JW
authors.lastname: Dudenhausen
mesh_terms: D001604:Berlin / Q000453:epidemiology; D001724:Birth Weight; D001827:Body Height; D015992:Body Mass Index; D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008423:Maternal Age; D010298:Parity; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012307:Risk Factors; D013997:Time Factors; D015430:Weight Gain