title: [Study on the clinical use of alpha-fetoprotein (AFP) colloidal gold diagnostic strip].
abstract: OBJECTIVE
  To test the sensitivity and specificity of alpha-fetoprotein (AFP) colloidal gold diagnostic strip as compared with RIA-AFP diagnostic kit.
  
  
  METHODS
  Double blind method was used to test sera from 426 healthy people and 1567 patients selected in two general hospitals and a cancer hospital. Each serum was measured by RIA-AFP and AFP colloidal gold diagnostic strip on the same day. RIA-AFP diagnostic results was identified as true positive or negative.
  
  
  RESULTS
  Among 426 healthy people, all the RIA-AFP test showed negative result (serum AFP concentration less than 25 IU/ml), but the AFP colloidal gold diagnostic strip had 1.88% false positive. When comparing the result from 1567 patients measured by RIA-AFP, the sensitivity and specificity of AFP colloidal gold diagnostic strip were 99.3%, and 97.2%, respectively. The crude correspondence rate between the two diagnostic regents was 97.6%.
  
  
  CONCLUSIONS
  AFP colloidal gold diagnostic strip showed very good result and could be used as a screening diagnostic kit in clinic and hospital settings.
authors.affiliation: Beijing Institute of Biological Prodects, Beijing 100024, China.
authors.forename: Xian-min
authors.initials: XM
authors.lastname: Jiang
authors.forename: Jian
authors.initials: J
authors.lastname: Kong
authors.forename: Tao
authors.initials: T
authors.lastname: Lin
authors.forename: Xiu-ying
authors.initials: XY
authors.lastname: Yu
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Dai
authors.forename: Hang-yan
authors.initials: HY
authors.lastname: Yang
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Sun
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Yong-quan
authors.initials: YQ
authors.lastname: Yang
authors.forename: Yan-chun
authors.initials: YC
authors.lastname: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D004311:Double-Blind Method; D017979:Gold Colloid; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis*; D011863:Radioimmunoassay; D011933:Reagent Kits, Diagnostic; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D017979:Gold Colloid; D011933:Reagent Kits, Diagnostic; D000509:alpha-Fetoproteins; C058457:Aurodye