Minimal effective dosage of recombinant human erythropoietin in spinal surgery.
Preoperative autologous blood donation is one of the most widely used methods of autotransfusion. However securing a predetermined amount of blood (3 units of whole blood) may be difficult in patients with a low preoperative hematocrit. To determine the minimum effective pretreatment dosage of recombinant human erythropoietin required to secure an adequate amount of preoperative blood for autologous transfusion during posterior decompression and instrumentation fusion using the pedicle screw-rod system in the lumbar spine, a prospective randomized clinical trial was done. Forty-five patients who had a preoperative hematocrit less than 40% were selected and were divided blindly into three groups. Fifty units per kilogram of recombinant human erythropoietin seems to be the minimal effective dosage for securing an adequate amount of preoperative autologous blood donation.
Lee
Ji-Ho
JH
Department of Orthopaedic Surgery, Seoul National University College of Medicine, Seoul Municipal Boramae Hospital, Dongjack-Gu, Korea. jiholee@brm.co.kr
Lee
Sang-Hoon
SH
Oh
Joo Han
JH
D000328:Adult; D016063:Blood Loss, Surgical; D001804:Blood Transfusion, Autologous / Q000379:methods*; D019299:Decompression, Surgical / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004911:Erythrocyte Volume; D004921:Erythropoietin / Q000008:administration & dosage*; D005260:Female; D006400:Hematocrit; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D011994:Recombinant Proteins; D019651:Plastic Surgery Procedures / Q000379:methods; D013131:Spine / Q000601:surgery*; D016896:Treatment Outcome
D011994:Recombinant Proteins; D004921:Erythropoietin