title: [A report of a case with Werner's syndrome suffering from end-stage renal failure].
abstract: A 54-year-old man was found to have hypertension at age 32, and a diagnosis of Werner's Syndrome was made at age 36 when he was examined for hyperlipidemia. Diabetes mellitus was found at age 42. Proteinuria appeared at age 49, and microscopic hematuria was seen at age 50. At age 51, serum creatinin level began to rise and atrophy of bilateral kidneys was observed by abdominal CT. There after, the renal function gradually worsened. At age 53, the serum creatinin level rose to 8.3 mg/dl, and systemic edema as well as loss of appetite appeared, resulting in the initiation of hemodialysis. In Werner's syndrome, though arteriosclerosis arises frequently, case reports with chronic renal failure are extremely rare. To investigate the cause of the renal dysfunction, renal biopsy was performed and the samples were histologically examined, revealing the presence of hypertensive glomerular changes. It is, thus, conceivable that hypertension had played a major role in the progression of renal failure in this case.
authors.affiliation: Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University.
authors.forename: Harukiyo
authors.initials: H
authors.lastname: Kawamura
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tsuchida
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Maezawa
authors.forename: Kazuki
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Sunao
authors.initials: S
authors.lastname: Asaumi
authors.forename: Koutaro
authors.initials: K
authors.lastname: Yokote
authors.forename: Seijiro
authors.initials: S
authors.lastname: Mori
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Saito
mesh_terms: D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014898:Werner Syndrome / Q000150:complications*