title: Isotretinoin and psychiatric illness in adolescents and young adults.
abstract: OBJECTIVE
  To evaluate the relationship between isotretinoin and psychiatric illness in adolescents and young adults.
  
  
  METHODS
  Primary literature located via MEDLINE (1966-December 2002). Key terms were isotretinoin, depression, psychosis, suicide, and adolescents.
  
  
  RESULTS
  Information regarding depression was added to isotretinoin labeling in 1998 following a series of case reports and submitted to the MedWatch system.
  
  
  CONCLUSIONS
  Although a causal relationship may exist between isotretinoin and psychiatric illness in adolescents and young adults, this has not been demonstrated in the literature. Until evidence establishes a presence or lack of causality, prescribers should exercise caution when treating adolescents and young adults with isotretinoin.
authors.affiliation: Division of Pharmacy Practice, St. Louis College of Pharmacy, St. Louis, MO 63110-1088, USA. senders@stlcop.edu
authors.forename: Shelly J
authors.initials: SJ
authors.lastname: Enders
authors.forename: Jason M
authors.initials: JM
authors.lastname: Enders
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect / Q000187:drug effects; D002986:Clinical Trials as Topic; D003863:Depression / Q000139:chemically induced / Q000453:epidemiology / Q000523:psychology; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D007641:Keratolytic Agents / Q000009:adverse effects*; D001523:Mental Disorders / Q000139:chemically induced* / Q000453:epidemiology; D018570:Risk Assessment
chemical_list: D007641:Keratolytic Agents; D015474:Isotretinoin