Congenital adrenal hyperplasia and acne in male patients.
Seborrhoea is one pathogenic factor for acne. Androgens induce sebum production, and excess androgen may provoke or aggravate acne. In women an androgen disorder is frequently suspected when acne is accompanied by hirsutism or menstrual irregularities. In men acne may be the only symptom of androgen excess. We report three male acne patients in whom hormonal screening revealed irregularities of androgen metabolism suggestive of late-onset congenital adrenal hyperplasia and who benefitted from low-dose glucocorticoids. Disorders of androgen metabolism may influence acne not only in women, but also in men, and these patients may benefit from low-dose glucocorticoid therapy.
Degitz
K
K
Department of Dermatology, Ludwig-Maximilian-University, München, Germany. klaus.degitz@lrz.uni-muenchen.de
Placzek
M
M
Arnold
B
B
Schmidt
H
H
Plewig
G
G
D000152:Acne Vulgaris / Q000188:drug therapy / Q000209:etiology*; D000287:Administration, Topical; D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000150:complications* / Q000188:drug therapy; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005938:Glucocorticoids; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D008775:Methylprednisolone