Thrombosis complicating high dose intravenous immunoglobulin: report of three cases and review of the literature.
High dose intravenous immunoglobulin (IVG) is increasingly used in a broad range of immune mediated diseases. Thrombosis was exceptionally reported as a complication of this therapy. We describe three cases of thrombotic complications during or soon after IVIG treatment: myocardial infarction in a man and cerebral infarctions in an elderly man, associated with peripheral ischemia in a woman. In addition we review the published cases in the literature and discuss the possible etiologic factors.
Zaidan
R
R
Neurology Division, College of Medicine, King Saud University, Riyadh; and Riyadh Medical Complex, Riyadh, Saudi Arabia. rzaidan@ksu.edu.sa
Al Moallem
M
M
Wani
B A
BA
Shameena
A R
AR
Al Tahan
A R
AR
Daif
A K
AK
Al Rajeh
S
S
D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000209:etiology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects* / Q000627:therapeutic use; D007511:Ischemia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D013927:Thrombosis / Q000209:etiology*; D014057:Tomography, X-Ray Computed / Q000379:methods
D016756:Immunoglobulins, Intravenous