title: Antifungal activity of the methanolic extract and alkaloids of Glaucium oxylobum.
abstract: The methanolic extract and total alkaloids of the aerial parts of Glaucium oxylobum exhibited good activity against Microsporum gypseum, Microsporum canis, Trichophyton mentagrophytes and Epidermophyton floccosum. Four alkaloids, dicentrine, glaucine, protopine, and alpha-allocryptopine, were identified as the compounds responsible for the antifungal activity of this plant.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. semnani_k@yahoo.co.uk
authors.forename: K
authors.initials: K
authors.lastname: Morteza-Semnani
authors.forename: Gh
authors.initials: G
authors.lastname: Amin
authors.forename: M R
authors.initials: MR
authors.lastname: Shidfar
authors.forename: H
authors.initials: H
authors.lastname: Hadizadeh
authors.forename: A
authors.initials: A
authors.lastname: Shafiee
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D028321:Plant Preparations; D029626:Ranunculaceae
chemical_list: D000470:Alkaloids; D000935:Antifungal Agents; D010936:Plant Extracts; D028321:Plant Preparations