Control of tRNA function by antisense PNA derivatives.
The interaction of antisense peptide nucleic acid (PNA) with yeast tRNA(Phe) was investigated. A 6-mer PNA complementary to the 3'-terminal sequence including the 73ACCA end hybridized to the tRNA. While the PNA with a single mismatch did not. PNA is a promising candidate for controlling tRNA functions by the sequence-specific hybridization.
Ninomiya
K
K
Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, 3-1-1 Tsushimanaka, Okayama 700-8530, Japan.
Endo
T
T
Hohsaka
T
T
Sisido
M
M
D000604:Amino Acyl-tRNA Synthetases / Q000737:chemistry; D016375:Antisense Elements (Genetics) / Q000737:chemistry* / Q000494:pharmacology; D001483:Base Sequence; D009693:Nucleic Acid Hybridization; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000494:pharmacology; D012343:RNA, Transfer / Q000737:chemistry* / Q000502:physiology
D016375:Antisense Elements (Genetics); D020135:Peptide Nucleic Acids; D012343:RNA, Transfer; D000604:Amino Acyl-tRNA Synthetases