Efficient nickel-mediated intramolecular amination of aryl chlorides.
The use of an in situ generated Ni(0) catalyst associated with 2,2'-bipyridine or N,N'-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene (SIPr) as a ligand and NaO-t-Bu as the base for the intramolecular coupling of aryl chlorides with amines is described. The procedure has been applied to the formation of five-, six-, and seven-membered rings. [reaction: see text]
Omar-Amrani
Rafik
R
Synthèse Organométallique et Réactivité, UMR CNRS UHP 7565, Université Henri Poincaré, Nancy I, BP 239, 54506 Vandoeuvre les Nancy Cedex, France.
Thomas
Antoine
A
Brenner
Eric
E
Schneider
Raphaël
R
Fort
Yves
Y