title: Antinociceptive activities of the hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu in mice.
abstract: This work studied the antinociceptive effects of the hydroalcoholic extracts (HAEs) from Erythrina velutina (Ev) and Erythrina mulungu (Em) in three experimental models of nociception in mice. The extract was administered intraperitoneally to female mice at the doses of 200 and 400 mg/kg. Inhibitions of abdominal contractions were observed with the doses of 200 (88.6%; 86.8%) and 400 (95.5%; 83.5%) mg/kg of E. velutina and E. mulungu, respectively, as compared to controls. E. velutina and E. mulungu, at both doses, reduced the nociception produced by formalin in the 1st and 2nd phases and this effect was not reversed by the pretreatment with naloxone. In the hot plate test an increase of the reaction time was observed only at 60 (Ev=18.0+/-2.2; Em=20.8+/-2.52) and 90 min (Ev=20.4+/-1.71; Em=23.7+/-2.32) after the treatment with E. velutina and E. mulungu at the dose of 400 mg/kg as compared to controls (T60=11.1+/-0.74; T90=11.9+/-0.86). This effect was not reversed by naloxone. We conclude that E. velutina and E. mulungu presents antinociceptive effects, which are independent of the opioid system.
authors.affiliation: Department of Physiology and Pharmacology, Federal University of Ceará, Brazil.
authors.forename: Silvânia Maria Mendes
authors.initials: SM
authors.lastname: Vasconcelos
authors.forename: Glício
authors.initials: G
authors.lastname: Rebouças Oliveira
authors.forename: Manuella
authors.initials: M
authors.lastname: Mohana de Carvalho
authors.forename: Alexandre César Praxedes
authors.initials: AC
authors.lastname: Rodrigues
authors.forename: Edilberto
authors.initials: E
authors.lastname: Rocha Silveira
authors.forename: Marta
authors.initials: M
authors.lastname: Maria França Fonteles
authors.forename: Francisca Cléa
authors.initials: FC
authors.lastname: Florenço Sousa
authors.forename: Glauce Socorro
authors.initials: GS
authors.lastname: Barros Viana
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D004895:Erythrina; D005260:Female; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010147:Pain Measurement / Q000379:methods*; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D009270:Naloxone; D009020:Morphine