title: Dimethylzinc-mediated addition of alkenylzirconocenes to alpha-keto and alpha-imino esters.
abstract: [reaction: see text] Hydrozirconation of alkynes followed by in situ transmetalation to dimethylzinc and 1,2-addition to activated ketones and N-diphenylphosphinoylimines leads to tertiary allylic alcohols and amines in high overall yield. With 8-phenylmenthol as the chiral auxiliary, si-face attack proceeds in good to excellent diastereoselectivities.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. wipf+@pitt.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Wipf
authors.forename: Corey R J
authors.initials: CR
authors.lastname: Stephenson