title: Linkage analysis suggests a locus of ichthyosis vulgaris on 1q22.
abstract: Ichthyosis vulgaris (IV) is an inherited scaling skin disorder with a prevalence estimated at 2.29% in China. The gene responsible for this disorder has not been elucidated. To find the disease gene, we ascertained two Chinese IV families. Linkage analysis identified an IV locus on chromosome 1q22 with a maximum two-point Lod score of 2.47 at D1S1653 (theta=0.00). Haplotype analysis placed the critical region in a 7-cM interval defined by D1S1653 and D1S2675. These results provide the basis for further identifying the gene responsible for IV disorder.
authors.affiliation: Health Science Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 20025 Shanghai, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhong
authors.forename: Bin
authors.initials: B
authors.lastname: Cui
authors.forename: Yizhi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Haisong
authors.initials: H
authors.lastname: Jiang
authors.forename: Shengcai
authors.initials: S
authors.lastname: Wei
authors.forename: Lei
authors.initials: L
authors.lastname: Bu
authors.forename: Guoping
authors.initials: G
authors.lastname: Zhao
authors.forename: Landian
authors.initials: L
authors.lastname: Hu
authors.forename: Xiangyin
authors.initials: X
authors.lastname: Kong
mesh_terms: D002681:China; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D016112:Ichthyosis Vulgaris / Q000235:genetics*; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree
chemical_list: D005819:Genetic Markers