Littorachalcone, a new enhancer of NGF-mediated neurite outgrowth, from Verbena littoralis.
A new dihydrochalcone dimer, 2',4',3",2"',4"'-pentahydroxy-4-O-4"-tetrahydrobichalcone, given the name littorachalcone, was isolated from the aerial parts of Verbena littoralis H. B. K. along with two known flavonoids 4'-hydroxywogonin and 8,3'-dimethoxy-5,7,4'-trihydroxyflavone. Littorachalcone caused a significant enhancement of nerve growth factor-mediated neurite outgrowth from PC12D cells.
Li
Yushan
Y
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Ishibashi
Masami
M
Chen
Xigui
X
Ohizumi
Yasushi
Y
D000818:Animals; D002599:Chalcone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D047188:Chalcones; D004357:Drug Synergism; D020932:Nerve Growth Factor / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects* / Q000502:physiology; D016716:PC12 Cells; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D032412:Verbena
D047188:Chalcones; D010936:Plant Extracts; D002599:Chalcone; D020932:Nerve Growth Factor; C015812:dihydrochalcone