title: Host immune responses against hog cholera virus in pigs treated with an ionized alkali mineral complex.
abstract: To determine the immune responses in pigs to hog cholera virus after treatment with an ionized alkali mineral complex (IAMC), 40 healthy pigs (28-32 days old) from a commercial swine farm were purchased and housed into 4 groups (n=10 each). All pigs were vaccinated intramuscularly (1 ml) with an attenuated live hog cholera virus (HCV, LOM strain) at 28-32 days old and challenged with a virulent hog cholera virus at 8 weeks after vaccination. Each group was treated with PowerFeel sprayed diet as 0.05% (w/w) in a final concentration (T-1, n=10), a diet mixed with SuperFeed as 3% (w/w) in a final concentration (T-2, n=10), or a diluted PowerFeel solution (1:500, v/v) as drinking water (T-3, n=10), respectively. A group (n=10) served as a non-treated control. Proportions of expressing CD2+ and CD8+ cells increased significantly (p<, 0.05) at 8-week post-application. Mean antibody titers of each group against HCV gradually increased to higher levels after vaccination and with challenge of the virulent virus. In conclusion, the IAMC-treated diets can be helpful for the improvement of growth in pigs with proper vaccination program, while the IAMC-treated diets have no effects on the clinical protection against hog cholera.
authors.affiliation: College of Veterinary Medicine, Seoul National University, 441-744 Suwon, Korea. parkx026@snu.ac.kr
authors.forename: Bong-Kyun
authors.initials: BK
authors.lastname: Park
authors.forename: Kwang-Soo
authors.initials: KS
authors.lastname: Lyoo
authors.forename: Yong-Ho
authors.initials: YH
authors.lastname: Park
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Koh
authors.forename: KyungSuk
authors.initials: K
authors.lastname: Seo
mesh_terms: D000468:Alkalies / Q000276:immunology / Q000494:pharmacology*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D006691:Classical Swine Fever / Q000276:immunology* / Q000517:prevention & control; D006692:Classical Swine Fever Virus / Q000276:immunology*; D005434:Flow Cytometry / Q000662:veterinary; D019084:Fluorescent Antibody Technique, Indirect / Q000662:veterinary; D006680:HLA Antigens / Q000276:immunology; D008903:Minerals / Q000276:immunology / Q000494:pharmacology*; D013552:Swine; D014611:Vaccination / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000468:Alkalies; D000914:Antibodies, Viral; D006680:HLA Antigens; D008903:Minerals; D014613:Vaccines, Attenuated; D014765:Viral Vaccines