title: Taurine-induced long-lasting enhancement of synaptic transmission in mice: role of transporters.
abstract: Taurine, a major osmolyte in the brain evokes a long-lasting enhancement (LLETAU) of synaptic transmission in hippocampal and cortico-striatal slices. Hippocampal LLETAU was abolished by the GABA uptake blocker nipecotic acid (NPA) but not by the taurine-uptake inhibitor guanidinoethyl sulphonate (GES). Striatal LLETAU was sensitive to GES but not to NPA. Semiquantitative PCR analysis and immunohistochemistry revealed that taurine transporter expression is significantly higher in the striatum than in the hippocampus. Taurine transporter-deficient mice displayed very low taurine levels in both structures and a low ability to develop LLETAU in the striatum, but not in the hippocampus. The different mechanisms of taurine-induced synaptic plasticity may reflect the different vulnerabilities of these brain regions under pathological conditions that are accompanied by osmotic changes such as hepatic encephalopathy.
authors.affiliation: Department of Neurophysiology, Heinrich-Heine-Universität, Düsseldorf, Germany. olga.sergeeva@uni-duesseldorf.de
authors.forename: O A
authors.initials: OA
authors.lastname: Sergeeva
authors.forename: A N
authors.initials: AN
authors.lastname: Chepkova
authors.forename: N
authors.initials: N
authors.lastname: Doreulee
authors.forename: K S
authors.initials: KS
authors.lastname: Eriksson
authors.forename: W
authors.initials: W
authors.lastname: Poelchen
authors.forename: I
authors.initials: I
authors.lastname: Mönnighoff
authors.forename: B
authors.initials: B
authors.lastname: Heller-Stilb
authors.forename: U
authors.initials: U
authors.lastname: Warskulat
authors.forename: D
authors.initials: D
authors.lastname: Häussinger
authors.forename: H L
authors.initials: HL
authors.lastname: Haas
mesh_terms: D000465:Algorithms; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D004594:Electrophysiology; D005260:Female; D005838:Genotype; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D026901:Membrane Transport Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology; D014179:Neurotransmitter Uptake Inhibitors / Q000494:pharmacology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013268:Stimulation, Chemical; D009435:Synaptic Transmission / Q000187:drug effects*; D013654:Taurine / Q000378:metabolism / Q000494:pharmacology*; D000099247:Taurine Transporters
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D014179:Neurotransmitter Uptake Inhibitors; D013654:Taurine; D000099247:Taurine Transporters