An improved procedure for the preparation of 8-substituted guanines.
The preparation of 8-substituted guanines using a new phosphorus(III)-mediated cyclisation of 4-acylamino-5-nitrosopyrimidines as the key step is described.
Xu
Ming
M
Laboratorium für Organische Chemie, ETH-Hönggerberg, CH-8093 Zürich, Switzerland.
De Giacomo
Fabio
F
Paterson
Duncan E
DE
George
Tesmol G
TG
Vasella
Andrea
A
D000215:Acylation; D003500:Cyclization; D006147:Guanine / Q000031:analogs & derivatives*; D008956:Models, Chemical; D009603:Nitroso Compounds / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry; D010084:Oxidation-Reduction; D010758:Phosphorus / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry*; D013329:Structure-Activity Relationship
D009603:Nitroso Compounds; D009943:Organophosphorus Compounds; D011743:Pyrimidines; C061896:triphenylphosphine; D010758:Phosphorus; D006147:Guanine