Mesalazine-associated benign intracranial hypertension in a patient with ulcerative colitis.
OBJECTIVE
To report a case of benign intracranial hypertension related to mesalazine use.


METHODS
Observational case report.


METHODS
A 23-year-old-woman with sudden visual loss, headache, and a history of ulcerative colitis treated with mesalazine underwent ophthalmologic examination, echography, magnetic resonance imaging, and lumbar puncture.


RESULTS
The examinations disclosed benign intracranial hypertension that resolved when mesalazine was discontinued and recurred when the drug was restarted.


CONCLUSIONS
We recommend periodic ocular fundus examination for patients undergoing long-term therapy with mesalazine, especially if decreased vision, headaches, or neck stiffness are present, to avoid potentially severe complications of intracranial hypertension
Rosa
Nicola
N
Eye Department, 2nd University of Naples, Naples, Italy. nocola.rosa@unina2.it
Giamundo
Arcangelo
A
Jura
Attilio
A
Iaccarino
Gennarfrancesco
G
Romano
Antonio
A
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D019804:Mesalamine / Q000009:adverse effects*; D009900:Optic Nerve / Q000000981:diagnostic imaging; D011559:Pseudotumor Cerebri / Q000139:chemically induced* / Q000000981:diagnostic imaging; D014463:Ultrasonography; D014786:Vision Disorders / Q000139:chemically induced
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine