title: [Clear cell carcinoma of the ovary simulating a yolk sac tumor].
abstract: Clear cell carcinoma (CCC) of the ovary is uncommon. In young patients, this tumor may simulate a yolk sac tumor. In this case, the morphologic distinction between these tumors is often difficult but the immunohistochemical staining for CA125 and alpha foeto protein (AFP) and the response to chemotherapy are particularly helpful to resolve this problem of differential diagnosis. We report a case of a 17 year old patient who was operated for a tumor of the right ovary. The diagnosis of a yolk sac tumor was first suggested. However, because of the non response to chemotherapy, a second laparotomy was performed; the definitive pathologic examination concluded to the diagnosis of a CCC of the ovary. The young age and the immunohistochemical staining for AFP are unusual and misleading features for a CCC. Our objective about this particular case is to discuss the anatomoclinical aspects of the CCC of the ovary and to prove the role of immunohistochemistry in the differential diagnosis.
authors.affiliation: Laboratoire d'anatomie et de cytologie pathologiques, CHU Habib Bourguiba de Sfax 3029, Tunisie.
authors.forename: Ibticem
authors.initials: I
authors.lastname: Bahri
authors.forename: Tahya
authors.initials: T
authors.lastname: Boudawara
authors.forename: Abdelmajid
authors.initials: A
authors.lastname: Khabir
authors.forename: Mohamed Issam
authors.initials: MI
authors.lastname: Beyrouti
authors.forename: Mounir
authors.initials: M
authors.lastname: Frikha
authors.forename: Rachid
authors.initials: R
authors.lastname: Jlidi
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D018394:CA-125 Antigen / Q000032:analysis; D003937:Diagnosis, Differential; D018240:Endodermal Sinus Tumor; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D018394:CA-125 Antigen; D000509:alpha-Fetoproteins