Opportunities and options for treatment research in resource-constrained settings.
HIV clinical research faces limitations even in research-rich settings. Even though important questions remain unanswered, clinical trials will probably never be conducted that address, prospectively, when treatment is optimally indicated, for example. In resource-constrained settings, large, prospective clinical trials are also unlikely. On the other hand, ones with a more observational design or that compare cohort experiences may well be feasible and able to provide information important in those settings, as well as in regions with abundant financial resources.
Volberding
Paul A
PA
University of California San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA. Paul.Volberding@med.va.gov
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D002986:Clinical Trials as Topic / Q000191:economics* / Q000639:trends; D015331:Cohort Studies; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy*; D006295:Health Resources; D006801:Humans; D011446:Prospective Studies; D012107:Research Design / Q000639:trends
D019380:Anti-HIV Agents