In vitro antimicrobial susceptibility of Brachyspira pilosicoli isolates from humans.
The in vitro antimicrobial susceptibility of the anaerobic intestinal spirochete Brachyspira pilosicoli was investigated by an agar dilution method. Human (n = 123) and porcine (n = 16) isolates were susceptible to metronidazole, ceftriaxone, meropenem, tetracycline, moxifloxacin, and chloramphenicol; erythromycin and ciprofloxacin were not active. Resistance to amoxicillin and clindamycin varied. Amoxicillin susceptibility was restored by clavulanic acid.
Brooke
C J
CJ
Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, Western Australia 6150, Australia.
Hampson
D J
DJ
Riley
T V
TV
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001372:Aza Compounds; D002443:Ceftriaxone / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones; D006801:Humans; D066298:In Vitro Techniques; D000077731:Meropenem; D008795:Metronidazole / Q000494:pharmacology*; D000077266:Moxifloxacin; D011804:Quinolines; D013144:Spirochaetales / Q000187:drug effects*; D013552:Swine; D013752:Tetracycline / Q000494:pharmacology; D013845:Thienamycins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D013845:Thienamycins; D008795:Metronidazole; D002701:Chloramphenicol; D002443:Ceftriaxone; D013752:Tetracycline; D000077731:Meropenem; D000077266:Moxifloxacin