HIV vaccines 1983-2003.
Twenty years after the discovery of HIV, there is still no vaccine. This year, an envelope vaccine aimed at stimulating neutralizing antibodies was unable to protect against infection in phase 3 trials. But more than 20 HIV vaccines designed to stimulate T-cell responses are being developed. Will any of them work?
McMichael
Andrew J
AJ
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9D5, UK. andrew.mcmichael@imm.ox.ac.uk
Hanke
Tomas
T
D016915:AIDS Vaccines / Q000276:immunology* / Q000627:therapeutic use*; D000906:Antibodies / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D002986:Clinical Trials as Topic; D015195:Drug Design; D006678:HIV / Q000235:genetics / Q000276:immunology; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology; D014614:Vaccines, Synthetic / Q000276:immunology
D016915:AIDS Vaccines; D000906:Antibodies; D014614:Vaccines, Synthetic