title: Simple mimetics of a nuclear localization signal (NLS).
abstract: [reaction: see text] Molecular modeling was used to design mimetics of the HIV-1 matrix protein nuclear localization signal (NLS) in which a scaffold of two resorcinol units joined by a diamide linker presents 3-aminopropyl ethers in place of lysine side chains. Prospective mimetics with linkers of 6, 8, 10, or 12 atoms were synthesized and compared in a competition assay for binding to the nuclear import receptor subunit karyopherin alpha, showing the 10-atom linker to be best and shorter ones ineffective.
authors.affiliation: University of Illinois at Chicago, Department of Chemistry (M/C 111), 845 West Taylor Street, Room 4500, Chicago, Illinois 60607, USA.
authors.forename: Seung Bum
authors.initials: SB
authors.lastname: Park
authors.forename: Thai H
authors.initials: TH
authors.lastname: Ho
authors.forename: Brian M
authors.initials: BM
authors.lastname: Reedy
authors.forename: Michael D
authors.initials: MD
authors.lastname: Connolly
authors.forename: Robert F
authors.initials: RF
authors.lastname: Standaert
mesh_terms: D018716:Molecular Mimicry; D019913:Nuclear Localization Signals
chemical_list: D019913:Nuclear Localization Signals