Synthesis and DNA binding properties of alkyl-linked bis(benzimidazole) compounds.
We have synthesized novel alkyl-linked bis(benzimidazole) compounds and studied their DNA binding properties by spectroscopic (absorption, CD, flow dichroism and fluorescence) and viscosity measurements. The results indicate that bis(benzimidazole) compounds interact with DNA both by intercalation and by groove binding.
Kubota
Y
Y
Department of Chemistry, Faculty of Science, Yamaguchi University, Yamaguchi 753-8512, Japan.
Fujii
H
H
Liu
J
J
Tani
S
S
D000478:Alkylation; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D001562:Benzimidazoles / Q000737:chemistry*; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D010419:Pentamidine / Q000737:chemistry; D013053:Spectrophotometry; D014783:Viscosity
D000890:Anti-Infective Agents; D001562:Benzimidazoles; D007364:Intercalating Agents; C009712:bis-benzimidazole; D010419:Pentamidine; D004247:DNA