title: Effects of combination dietary conjugated linoleic acid with vitamin A (retinol) and selenium on the response of the immunoglobulin production in mice.
abstract: The dietary effect of conjugated linoleic acid (CLA) on the response of the immunoglobulin (serum and tissue) production in Balb/C mice was examined at three doses: 0 %(control), 0.5% and 1.5%. The combination effects of CLA with vitamin ADE or selenium also were investigated. CLA at 0.5% increased serum immunoglobulin A, G, mesenteric lymph node (MHN) and gut luminal IgA (secretory IgA) levels. However, 1.5% CLA decreased SIgG slightly. CLA both alone and combined with vitamin ADE and selenium did not affect serum IgE. The levels of immunoglobulin concentration in the 0.5% CLA group were higher than those in the 1.5% CLA group. The level of serum IgG in 1.5% CLA combined with selenium was maintained at the same level as that of control. It is considered that over- doses of CLA (1.5%) even depressed the production of immunoglobulin but selenium and/or vitamin inhibited this activity to a certain extent. In this study, dietary CLA increased immunoglobulin production in a dose-dependent manner. Vitamin ADE and Selenium combined with CLA also increased the immunoglobulin production response except serum IgE.
authors.affiliation: College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.
authors.forename: Jin-young
authors.initials: JY
authors.lastname: Kim
authors.forename: Byung-hyun
authors.initials: BH
authors.lastname: Chung
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D007136:Immunoglobulins / Q000096:biosynthesis* / Q000097:blood / Q000276:immunology; D007422:Intestines / Q000187:drug effects / Q000276:immunology; D019787:Linoleic Acid / Q000494:pharmacology*; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012643:Selenium / Q000494:pharmacology*; D014801:Vitamin A / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D007136:Immunoglobulins; D014801:Vitamin A; D019787:Linoleic Acid; D012643:Selenium