title: Relationship between the expression of alpha 1-antitrypsinase in bronchioalveolar carcinoma and clinical pathology.
abstract: By using immunohistochemistry LSAB method and imaging analysis technique, the expression of alpha 1-antitrypsinase (alpha 1-AT) in 41 cases of bronchioalveolar carcinoma (BAC) was quantitatively detected to explore the relationship between alpha 1-AT expression in BAC tissues and clinical pathology. The results showed that the total positive rate for alpha 1-AT expression was 85.4%. The positive rate for alpha 1-AT expression in alveolar BAC was 100%, with the immunity reactive staining intensity being significantly higher than in papillary BAC, mucinous BAC or sclerosing BAC (P < 0.05). The positive rate in papillary BAC was 93.3%, with the intensity higher mucinous BAC or sclerosing BAC (P < 0.01); The positive rate in both mucinous BAC and sclerosing BAC was 66.7% (P > 0.05); The expression intensity in lymph node metastatic group was obviously lower than that in the group without metastasis (P < 0.01); The patients with mucinous BAC were diagnosed at a younger age than those with other histologic types of BAC (P < 0.05). It was suggested that BAC cells could also produce alpha 1-AT. Detection of alpha 1-AT could be used as a new method to diagnose BAC and might play a role in assessing BAC metastasis.
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Tongji Medical University, Wuhan 430030.
authors.forename: C
authors.initials: C
authors.lastname: Wu
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: C
authors.initials: C
authors.lastname: Hao
authors.forename: J
authors.initials: J
authors.lastname: Ni
authors.forename: D
authors.initials: D
authors.lastname: Che
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000378:metabolism* / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000378:metabolism; D014408:Biomarkers, Tumor; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D000515:alpha 1-Antitrypsin / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D000515:alpha 1-Antitrypsin