title: The relationship between Lewy body disease, Parkinson's disease, and Alzheimer's disease.
abstract: The nosological relationship between Parkinson's disease, dementing syndromes with Lewy bodies, and Alzheimer's disease has been the subject of continuing debate. Here I argue, on the basis of recent data from families with hereditary versions of these diseases and from transgenic modeling, that these nosological debates are inevitable, impossible to resolve, and a product of the fact that we define diseases as entities rather than processes.
authors.affiliation: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. hardyj@mail.nih.gov
authors.forename: John
authors.initials: J
authors.lastname: Hardy
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D020961:Lewy Body Disease / Q000503:physiopathology*; D051379:Mice; D010300:Parkinson Disease / Q000503:physiopathology*