title: Relationship between ST-segment morphology and conduction disturbances detected by signal-averaged electrocardiography in Brugada syndrome.
abstract: BACKGROUND
  Although arrhythmogenesis of Brugada syndrome is still unknown, it has been reported to be associated with conduction disturbances. Two ST-segment morphologies (coved and saddle-back patterns) have been described in this syndrome. No study has sought to determine which morphology has stronger conduction disturbances, thereby associating with life-threatening events.
  
  
  METHODS
  Forty-six patients who presented the Brugada-type ECG with either of a characteristic coved (n = 25) or saddle-back (n = 21) pattern of ST-segment morphology underwent signal-averaged ECG (SAECG). SAECG parameters, and the history of life-threatening events defined as syncope or aborted sudden death, were compared between groups.
  
  
  RESULTS
  Although filtered QRS duration did not differ between groups, the incidence of late potentials in the coved group was higher than in the saddle-back group (22 patients (88%) versus 4 patients (19%); P < 0.01), showing lower RMS40 and longer LAS40. Life-threatening events occurred in 17 patients (68%) in the coved group and 7 patients (33%) in the saddle-back group (P = 0.02).
  
  
  CONCLUSIONS
  The coved pattern of ST segment was more closely related to conduction disturbances than the saddle-back pattern in patients with Brugada-type ECG. Life-threatening events were more common in patients with the coved ST-segment elevation. Conduction disturbances in the coved pattern of ST segment may reflect a substrate of arrhythmogenesis in Brugada syndrome.
authors.affiliation: Third Department of Internal Medicine, Ohashi Hospital, Toho University School of Medicine, Tokyo, Japan.
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Takami
authors.forename: Takanori
authors.initials: T
authors.lastname: Ikeda
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Enjoji
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sugi
mesh_terms: D000328:Adult; D002037:Bundle-Branch Block / Q000175:diagnosis* / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012815:Signal Processing, Computer-Assisted; D013577:Syndrome; D014693:Ventricular Fibrillation / Q000175:diagnosis* / Q000503:physiopathology*