Influence of depressive mood on the association of CRP and obesity in 3205 middle aged healthy men.
We studied concentrations of C-reactive proteins (CRP) in a population-based sample of 3204 men aged 45-74 years. Obesity was identified in 726 (23%) men (body mass index (BMI) >30 kg/m(2)). Stratification of the sample into three levels of depressive mood revealed a significant association between increased CRP in the obese sample with highest level of depression in comparison to the low level obese depression group (p=.013). The obesity x depression interaction was significant (p=.021). Multivariate analysis confirmed this effect after adjusting for possible confounding variables (age, high blood pressure, smoking, physical inactivity, low social class, and low alcohol intake) (p=.008). In the non-obese sample, there was no association between depressive mood and concentrations of CRP. These findings suggest a possible synergistic effect of obesity and depressive mood on chronic low level inflammation which may play a crucial role in the pathogenesis of atherosclerosis.
Ladwig
Karl-Heinz
KH
GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstädter Landstr. 1, Neuherberg 85764, Germany. ladwig@gsf.de
Marten-Mittag
Birgitt
B
Löwel
Hannelore
H
Döring
Angela
A
Koenig
Wolfgang
W
D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology / Q000378:metabolism*; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism*; D012016:Reference Values; D012307:Risk Factors
D002097:C-Reactive Protein