Factors predictive of corticosteroid psychosis in patients with systemic lupus erythematosus.
Corticosteroid-induced psychosis occurred in 5% of a prospective cohort of 92 patients with systemic lupus erythematosus (SLE). Psychosis was unpredictable by the routes and dosage of corticosteroid used. Factors predictive of psychosis were low serum levels of albumin, complement, and creatinine; history of anxiety disorders; and a family history of psychiatric illnesses. After multivariate adjustment, only hypoalbuminemia remained significant.
Chau
Shuk Yi
SY
Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong SAR, China.
Mok
Chi Chiu
CC
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000453:epidemiology; D015984:Causality; D015331:Cohort Studies; D015897:Comorbidity; D003176:Complement C3 / Q000032:analysis; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D034141:Hypoalbuminemia / Q000175:diagnosis / Q000453:epidemiology*; D015994:Incidence; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D011237:Predictive Value of Tests; D011241:Prednisone / Q000009:adverse effects / Q000627:therapeutic use; D011446:Prospective Studies; D011605:Psychoses, Substance-Induced / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*
D000305:Adrenal Cortex Hormones; D003176:Complement C3; D003404:Creatinine; D011241:Prednisone; D008775:Methylprednisolone