Augmentation of recombinant CH50 polypeptide on the function of macrophages of mice during chemotherapy.
The immunosuppressive model of mice was made by intraperitoneal injection of cyclophosphamide. The effect of CH50, a recombinant polypeptide of human fibronectin, on macrophages of mice was observed. The results showed that continuous intraperitoneal injection of CH50 could prevent the reduction of the number of monocytes in periphery blood and abdominal cavity by chemotherapeutic agents, enhance the metabolic activity and cytotoxicity of macrophages and augment the proliferation of splenocytes. The results suggested that CH50 is a product which could be used to improve the efficacy of chemotherapy of tumors.
Zhang
G
G
Department of Medical Molecular Biology, Tongji Medical University, Wuhan 430030.
Feng
Z
Z
Li
D
D
Cao
H
H
Zhang
H
H
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D003602:Cytotoxicity, Immunologic; D005353:Fibronectins / Q000096:biosynthesis* / Q000235:genetics / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000276:immunology*; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000276:immunology*; D051379:Mice; D011897:Random Allocation; D011994:Recombinant Proteins / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; C478562:CH50 recombinant polypeptide; D005353:Fibronectins; D011994:Recombinant Proteins