title: Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties.
abstract: In order to develop therapeutic agents against neurodegenerative diseases, we designed novel antioxidants containing N-t-butyl-N-hydroxylaminophenyl moieties and evaluated in vitro and in vivo neuroprotective properties as well as anti-ischemic effects.
authors.affiliation: Department of Chemistry, Yonsei University, 120-749, Seoul, South Korea.
authors.forename: Kyung Mi
authors.initials: KM
authors.lastname: Kim
authors.forename: Kyung Hwa
authors.initials: KH
authors.lastname: Kim
authors.forename: Tae Cheon
authors.initials: TC
authors.lastname: Kang
authors.forename: Won Yeon
authors.initials: WY
authors.lastname: Kim
authors.forename: Myung ryul
authors.initials: Mr
authors.lastname: Lee
authors.forename: Hyuk Jun
authors.initials: HJ
authors.lastname: Jung
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Sung Bo
authors.initials: SB
authors.lastname: Ko
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Koh
authors.forename: Moo Ho
authors.initials: MH
authors.lastname: Won
authors.forename: Eu gene
authors.initials: Eg
authors.lastname: Oh
authors.forename: Injae
authors.initials: I
authors.lastname: Shin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology; D006898:Hydroxylamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D054833:Isoindoles; D015227:Lipid Peroxidation / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D016566:Organoselenium Compounds / Q000494:pharmacology; D010084:Oxidation-Reduction
chemical_list: D000975:Antioxidants; D001393:Azoles; D016166:Free Radical Scavengers; D006898:Hydroxylamines; D054833:Isoindoles; C481318:N-t-butyl-N-hydroxylaminophenyl; D018696:Neuroprotective Agents; D016566:Organoselenium Compounds; C042986:ebselen