title: From subgenome analysis to protein structure.
abstract: Groups of related genes abound in large eukaryotic genomes. In such 'subgenomes', homology modeling carried out for a few genes will probably have relevance to the entire group. Subgenomes also afford unique ways of determining protein structural information. In addition to analyses based on the quantification of residue variability in paralogs, two-way comparisons, both within and among species, help to disclose functional amino acids. Comparative studies of gene families throughout the mammalian genome will also help elucidate the functional significance of single nucleotide polymorphisms in coding regions.
authors.affiliation: The Crown Human Genome Center, The Weizmann Institute of Science, Rehovot, 76100, Israel.
authors.forename: Orna
authors.initials: O
authors.lastname: Man
authors.forename: Tal
authors.initials: T
authors.lastname: Atarot
authors.forename: Avital
authors.initials: A
authors.lastname: Sadot
authors.forename: Tsviya
authors.initials: T
authors.lastname: Olender
authors.forename: Doron
authors.initials: D
authors.lastname: Lancet
mesh_terms: D000818:Animals; D001665:Binding Sites; D016000:Cluster Analysis; D017124:Conserved Sequence; D006801:Humans; D008322:Mammals / Q000235:genetics; D005810:Multigene Family / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018035:Receptors, Odorant / Q000235:genetics*; D017385:Sequence Homology; D026801:Synteny
chemical_list: D018035:Receptors, Odorant