Treatment with dihydroethidium reduces infarct size after transient focal cerebral ischemia in mice.
A transient focal ischemia model with C57Bl/6 mice was used to investigate whether dihydroethidium is neuroprotective. Different doses (25, 50, 100 mg/kg body weight) were used for pretreatment and the lowest effective dose was used for delayed treatment 1 and 2 h after reperfusion. Our results demonstrate that all the doses used for treatment reduced infarct volume. We conclude that dihydroethidium is neuroprotective by reducing superoxide in mice after stroke.
Yu
Fengshan
F
Department of Neurosurgery, Stanford University School of Medicine, 1201 Welch Road, MSLS #P304, Stanford, CA 94305-5487, USA.
Sugawara
Taku
T
Chan
Pak H
PH
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001929:Brain Edema / Q000188:drug therapy; D001931:Brain Mapping; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000209:etiology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004996:Ethidium / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D020244:Infarction, Middle Cerebral Artery / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D015427:Reperfusion Injury / Q000517:prevention & control*; D013997:Time Factors
D018696:Neuroprotective Agents; C067883:dihydroethidium; D004996:Ethidium