title: Antiprotozoal 6-substituted-5,6-dihydro-alpha-pyrones from Raimondia cf. monoica.
abstract: Dichloromethane extracts of both the roots and the leaves of Raimondia cf. monoica showed in vitro antiplasmodial and leishmanicidal activities against Plasmodium falciparum and Leishmania panamensis, respectively. Three 6-substituted 5,6-dihydro-2H-pyran-2-ones were isolated. (1) and (2) were identified as (6S)-(5'-oxohepten-1'E,3'E-dienyl)-5,6-dihydro-2H-pyran-2-one (1) and (6R)-(5'-oxohepten-1'Z,3'E-dienyl)-5,6-dihydro-2H-pyran-2-one (2), respectively. (-)-Arentilactone (3) was also isolated. The structure of the new compound (1) was determined by spectroscopic methods; additional spectroscopic data for (2) are reported for the first time.
authors.affiliation: Institute of Chemistry, Universidad de Antioquia, P.O. Box 1226, Medellín-Colombia.
authors.forename: Doris
authors.initials: D
authors.lastname: Carmona
authors.forename: Jairo
authors.initials: J
authors.lastname: Sáez
authors.forename: Hillmer
authors.initials: H
authors.lastname: Granados
authors.forename: Edwin
authors.initials: E
authors.lastname: Pérez
authors.forename: Silvia
authors.initials: S
authors.lastname: Blair
authors.forename: Alberto
authors.initials: A
authors.lastname: Angulo
authors.forename: Bruno
authors.initials: B
authors.lastname: Figadere
mesh_terms: D000818:Animals; D029061:Annonaceae / Q000737:chemistry*; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007783:Lactones / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C478121:(6S)-(5'-oxohepten-1'E,3'E-dienyl)-5,6-dihydro-2H-pyran-2-one; D000981:Antiprotozoal Agents; D007783:Lactones; D011753:Pyrones; C478120:arentilactone