Jejunal atresia related to the use of toluidine blue in genetic amniocentesis in twins.
Since 1990 avoidance of methylene blue as a dye in diagnostic amniocentesis is recommended. This is the result of the observation that a high incidence of jejuno-ileal atresia appeared in twin pregnancies following intraamniotic injection of methylene blue. We report a case of jejunal atresia in twins after injection of toluidine blue. We describe the clinical course, discuss possible teratogenic mechanisms and emphasize that no synthetic dyes should be used in second trimester amniocentesis.
Dinger
Jürgen
J
Clinic of Pediatrics, Medical Faculty, Technical University of Dresden, Germany. DINGER@ukd80.med.tu-dresden.de
Autenrieth
Arnd
A
Kamin
Gabriele
G
Goebel
Peter
P
Hinkel
Georg-Klaus
GK
D000328:Adult; D000649:Amniocentesis; D004396:Coloring Agents / Q000009:adverse effects*; D004200:Diseases in Twins; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007409:Intestinal Atresia / Q000139:chemically induced* / Q000601:surgery; D007583:Jejunum / Q000002:abnormalities* / Q000601:surgery; D011247:Pregnancy; D014048:Tolonium Chloride / Q000009:adverse effects*
D004396:Coloring Agents; D014048:Tolonium Chloride