[Prevention of dental fluorosis by glutamic acid].
The preventive effect of glutamic acid on the clinical manifestation of dental fluorosis was studied in rat experiments. Young rats receiving fluorinated (15 mg/liter) drinking water during 4-5 weeks developed depigmentation characteristic of dental fluorosis. No depigmentation was observed in rats receiving water with the same content of fluorine in parallel with glutamic acid (twice a week). The enamel in this latter group virtually did not differ from normal dental enamel in rats receiving standard vivarium rations. Hence, glutamic acid prevented dental fluorosis by neutralizing the toxic effect of high fluorine dose. Biochemical parameters of the blood (Ca, P, total protein, AlAT, AsAT) also indicated the corrective effect of this amino acid.
Pashaev
Ch A
ChA
Aliev
A N
AN
Mamedova
S A
SA
D000818:Animals; D009050:Fluorosis, Dental / Q000517:prevention & control*; D018698:Glutamic Acid / Q000627:therapeutic use*; D023421:Models, Animal; D051381:Rats
D018698:Glutamic Acid