title: Models for assessing the role of selenoproteins in health.
abstract: Two model systems for examining the role of selenoproteins in health are discussed. One utilizes transgenic mice that carry mutant selenocysteine (Sec) tRNA transgenes that result in the reduction of selenoprotein expression in a protein- and tissue-specific manner. The other utilizes loxP-Cre technology to selectively remove the Sec tRNA gene in mammary epithelium that results in the reduction of only certain selenoproteins in this tissue. Both approaches provide important tools for examining the role of selenoproteins in health.
authors.affiliation: Section on the Molecular Biology of Selenium, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Mohamed E
authors.initials: ME
authors.lastname: Moustafa
authors.forename: Easwari
authors.initials: E
authors.lastname: Kumaraswamy
authors.forename: Nianxin
authors.initials: N
authors.lastname: Zhong
authors.forename: Mahadev
authors.initials: M
authors.lastname: Rao
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Carlson
authors.forename: Dolph L
authors.initials: DL
authors.lastname: Hatfield
mesh_terms: D000818:Animals; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008954:Models, Biological; D011506:Proteins / Q000502:physiology*; D012346:RNA, Transfer, Amino Acyl / Q000235:genetics*; D017279:Selenocysteine / Q000235:genetics*; D051140:Selenoproteins
chemical_list: D011506:Proteins; D012346:RNA, Transfer, Amino Acyl; D051140:Selenoproteins; C112705:selenocysteinyl-tRNA; D017279:Selenocysteine