title: A transient N-O-linked Pauson-Khand strategy for the synthesis of the deschloro carbocyclic core of the palau'amines and styloguanidines.
abstract: A stereocontrolled route to the deschloro cyclopentyl core of the palau'amines and styloguanidines has been developed. This strategy makes use of the intramolecular Pauson-Khand cyclization of an enyne with a "transient N-O tether" to construct a five-membered carbocycle in a diastereoselective fashion. [reaction: see text]
authors.affiliation: Department of Chemistry, Yale University, 225 Prospect Street, P.O. Box 208107, New Haven, CT 06520-8107, USA.
authors.forename: Stefan G
authors.initials: SG
authors.lastname: Koenig
authors.forename: Stefan M
authors.initials: SM
authors.lastname: Miller
authors.forename: Kristi A
authors.initials: KA
authors.lastname: Leonard
authors.forename: Ralf S
authors.initials: RS
authors.lastname: Löwe
authors.forename: Betty C
authors.initials: BC
authors.lastname: Chen
authors.forename: David J
authors.initials: DJ
authors.lastname: Austin