[In vitro effects of acetylcholine, dopamine, histamine and serotonin on tracheal smooth muscle response during hypersecretion and normal secretion of tracheal glands].
It is expressed in vitro answer of the soft musculature of the tracheobronchial system of the newborns from 12 to 18 weeks of the gestation, with the hypersecretion and normosecretin of the tracheal gland. On 30 tracheal preparations taken by autopsy' of the dead children, was followed-up the answer of the tracheal soft musculature (SMT) on acetylcholine, dopamine, histamine and serotonine in the concentrations from 110(-4), 10(-3), 10(-2), 10(-1) M/L. The results illustrate that acetylcholyne, and histamine in the mentioned concentrations provoked the statistically significant answers of GMT with the hypersecretion and normosecretion of the tracheal glands (p < 0.01). On the contrary, dopamine and serotonine have not provoked statistically significant answers of these structures (p > 0.1), what illustrates that also dopaminergic and serotoninergic receptors at tracheobronchila system are not sufficient developed in this age of life. The answers of the tracheal-bronchial rings with hypersection of the tracheal glands a little more emphasized than the answers with normosecretion of the glands, but this difference is not statistically significant (p > 0.1).
Islami
Hilmi
H
Medicinski Fakultet Univerziteta u Pristini, Kosovo.
Shabani
R
R
Rama
Adem
A
Disba
M
M
Dida
B
B
Azizi
E
E
D000109:Acetylcholine / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D005088:Exocrine Glands / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D009093:Mucus / Q000378:metabolism*; D009129:Muscle Tonus / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000502:physiology*; D011954:Receptors, Dopamine / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects*
D011950:Receptors, Cholinergic; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012701:Serotonin; D006632:Histamine; D000109:Acetylcholine; D004298:Dopamine