title: [Atypical hyperplasia of endometrium and hysteroscopy].
abstract: OBJECTIVE
  To evaluate the risk of discovering an endometrial cancer when atypical hyperplasia was diagnosed by either endometrial samples using the pipelle device or hysteroscopic resection products.
  
  
  METHODS
  A retrospective monocentric study from january 1990 to july 2000. Twenty-three patients with atypical hyperplasia were included. Initial endometrial status was provided by endometrial biopsyduring diagnosis hysteroscopy (12 cases) or by operative hysteroscopic resection products (11 cases). For 23 patients, operative hysteroscopy and analyse of products resected were performed. For all patients, there was no hysteroscopical aspect evocative of adenocarcinoma. For 23 patients, histopathological analysis of the hysterectomy piece precised the final diagnosis.
  
  
  RESULTS
  Among the 23 hysterectomy pieces, 7 adenocarcinomas were diagnosed (30.4%). Risk for discovering adenocarcinoma when atypical hyperplasia was diagnosed by means of the pipelle biopsy device was 50% (6/12). Risk for discovering adenocarcinoma when atypical hyperplasia was diagnosed by means of operative hysteroscopy resection products was 5.9 % (1/17).
  
  
  CONCLUSIONS
  Atypical endometrial hyperplasia evidenced by pipelle biopsy device is often associated with adenocarcinoma. Diagnosis hysteroscopy however does not show evident pathological aspect of adenocarcinoma in such cases. Operative hysteroscopy allows in most cases correction of endometrial status. Risk of omitting adenocarcinoma when atypical hyperplasia is discovered on hysteroscopic resection pieces is low.
authors.affiliation: Service de gynécologie-obstétrique B, hôpital La Conception, 147, boulevard Baille, 13385 cedex 05, Marseille, France. aubert.agostini@wanadoo.fr <aubert.agostini@wanadoo.fr>
authors.forename: A
authors.initials: A
authors.lastname: Agostini
authors.forename: V
authors.initials: V
authors.lastname: Schaeffer
authors.forename: L
authors.initials: L
authors.lastname: Cravello
authors.forename: F
authors.initials: F
authors.lastname: Bretelle
authors.forename: V
authors.initials: V
authors.lastname: Roger
authors.forename: B
authors.initials: B
authors.lastname: Blanc
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis; D001706:Biopsy; D004714:Endometrial Hyperplasia / Q000175:diagnosis* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000175:diagnosis; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D012189:Retrospective Studies