title: Centrosome size is controlled by centriolar SAS-4.
abstract: The centrosome consists of a pair of centrioles and a surrounding matrix of pericentriolar material that anchors microtubule nucleation sites and consequently determines the number and organization of microtubules in interphase and mitotic cells. Recent studies utilizing a functional genomics approach in the nematode worm Caenorhabditis elegans and sophisticated light and electron microscopy techniques provide new insight into how centrioles act as centrosomal organizers and use a centriolar structural element to dictate centrosome size by defining their capacity to recruit pericentriolar material.
authors.affiliation: Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA. salisbury@mayo.edu
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Salisbury
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D002455:Cell Division / Q000502:physiology*; D002502:Centrioles / Q000378:metabolism* / Q000648:ultrastructure; D018385:Centrosome / Q000378:metabolism* / Q000648:ultrastructure; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D022101:Microtubule-Organizing Center / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D029742:Caenorhabditis elegans Proteins; C472409:SAS-4 protein, C elegans