The Chronic Renal Insufficiency Cohort (CRIC) Study: Design and Methods.
Insights into end-stage renal disease have emerged from many investigations but less is known about the epidemiology of chronic renal insufficiency (CRI) and its relationship to cardiovascular disease (CVD). The Chronic Renal Insufficiency Cohort (CRIC) Study was established to examine risk factors for progression of CRI and CVD among CRI patients and develop models to identify high-risk subgroups, informing future treatment trials, and increasing application of preventive therapies. CRIC will enroll approximately 3000 individuals at seven sites and follow participants for up to 5 yr. CRIC will include a racially and ethnically diverse group of adults aged 21 to 74 yr with a broad spectrum of renal disease severity, half of whom have diagnosed diabetes mellitus. CRIC will exclude subjects with polycystic kidney disease and those on active immunosuppression for glomerulonephritis. Subjects will undergo extensive clinical evaluation at baseline and at annual clinic visits and via telephone at 6 mo intervals. Data on quality of life, dietary assessment, physical activity, health behaviors, depression, cognitive function, health care resource utilization, as well as blood and urine specimens will be collected annually. (125)I-iothalamate clearances and CVD evaluations including a 12-lead surface electrocardiogram, an echocardiogram, and coronary electron beam or spiral CT will be performed serially. Analyses planned in CRIC will provide important information on potential risk factors for progressive CRI and CVD. Insights from CRIC should lead to the formulation of hypotheses regarding therapy that will serve as the basis for targeted interventional trials focused on reducing the burden of CRI and CVD.
Feldman
Harold I
HI
Center for Clinical Epidemiology, Philadelphia, 19104, USA. hfeldman@cceb.med.upenn.edu
Appel
Lawrence J
LJ
Chertow
Glenn M
GM
Cifelli
Denise
D
Cizman
Borut
B
Daugirdas
John
J
Fink
Jeffrey C
JC
Franklin-Becker
Eunice D
ED
Go
Alan S
AS
Hamm
L Lee
LL
He
Jiang
J
Hostetter
Tom
T
Hsu
Chi-Yuan
CY
Jamerson
Kenneth
K
Joffe
Marshall
M
Kusek
John W
JW
Landis
J Richard
JR
Lash
James P
JP
Miller
Edgar R
ER
Mohler
Emile R
ER
Muntner
Paul
P
Ojo
Akinlolu O
AO
Rahman
Mahboob
M
Townsend
Raymond R
RR
Wright
Jackson T
JT
D000328:Adult; D017677:Age Distribution; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000628:therapy; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011379:Prognosis; D006435:Renal Dialysis / Q000706:statistics & numerical data; D012107:Research Design; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D015996:Survival Rate; D014481:United States / Q000453:epidemiology