title: Four facets of a single brain: behaviour, cerebral blood flow/metabolism, neuronal activity and neurotransmitter dynamics.
abstract: Is functional neuroimaging a royal way to understand brain function or is it a new phrenology without an exact understanding what we measure? After two decades of imaging revolution, more and more authors ask this question. Brain functions are multidimensional, which can be approached from the point of (1) behavioural measures, (2) brain activation as reflected by blood flow and metabolic changes, (3) electrical activity of cells and cell-populations, and (4) neurotransmitter dynamics (release, receptor binding and reuptake). Using imaging techniques, we must take into consideration that even during the simplest task all of these processes operate in a closely interacting manner. Therefore, before drawing final conclusions about brain functions on the basis of a single aspect of these mechanisms, we must clarify the exact relationship among them. In this paper, we address this issue in order to draw attention to a number of uncertainties and controversies in the relationship of the four facets of brain functions.
authors.affiliation: Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden.
authors.forename: Szabolcs
authors.initials: S
authors.lastname: Kéri
authors.forename: Balázs
authors.initials: B
authors.lastname: Gulyás
mesh_terms: D001519:Behavior / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping; D003952:Diagnostic Imaging / Q000379:methods; D006801:Humans; D009474:Neurons / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D017711:Nonlinear Dynamics; D012039:Regional Blood Flow / Q000502:physiology; D014796:Visual Perception
chemical_list: D018377:Neurotransmitter Agents