Cell growth inhibitory effect of cinnamic acid derivatives from propolis on human tumor cell lines.
A cell growth inhibitory effect of drupanin and baccharin, ingredients of propolis, was found in human cancer cell lines. These compounds induced apoptosis in the cells characterized by morphological and nucleosomal DNA fragmentation analysis. Their effects were less potent compared with that of artepillin C, which is a known anticancer compound from propolis. Importantly, HL60 cells were more sensitive to drupanin than were Con A-stimulated peripheral blood lymphocytes, whereas the potency of artepillin C was the opposite of that of drupanin.
Akao
Yukihiro
Y
Gifu International Institute of Biotechnology, Kakamigahara, Japan. yakao@giib.or.jp
Maruyama
Hiroe
H
Matsumoto
Kenji
K
Ohguchi
Kenji
K
Nishizawa
Kumi
K
Sakamoto
Takashi
T
Araki
Yoko
Y
Mishima
Satoshi
S
Nozawa
Yoshinori
Y
D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011429:Propolis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D002934:Cinnamates; D006131:Growth Inhibitors; D010936:Plant Extracts; C029010:cinnamic acid; D011429:Propolis