Relief of symptoms in patients with group A beta-hemolytic streptococcus tonsillopharyngitis: comparison between telithromycin and penicillin V.
This study compared the resolution of symptoms in patients with group A beta-hemolytic streptococcus tonsillopharyngitis treated with 5 d of telithromycin 800 mg once daily, or 10 d of penicillin V 500 mg 3 times daily. At days 3-5 of treatment, the mean improvement in total symptom score was greater with telithromycin than with penicillin V (p = 0.042). Thus, telithromycin provided faster symptom relief than penicillin V.
Norrby
S Ragnar
SR
Swedish Institute for Infectious Disease Control, Solna, Sweden. Ragnar.Norrby@smi.ki.se
Chang
Joanne
J
Stewart
John A
JA
Brumpt
Ivan
I
Conway
Donald P
DP
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D048628:Ketolides; D018942:Macrolides; D008297:Male; D017060:Patient Satisfaction; D010404:Penicillin V / Q000008:administration & dosage*; D010612:Pharyngitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D011336:Probability; D012720:Severity of Illness Index; D013290:Streptococcal Infections / Q000175:diagnosis / Q000188:drug therapy*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000302:isolation & purification; D014069:Tonsillitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; C106791:telithromycin; D010404:Penicillin V