title: Yielding at stop codons: expanding the genetic code.
abstract: Codon-specific incorporation of noncoded amino acids into proteins can diversify the genetic code. Now, in both E. coli and S. cerevisiae, iterative rounds of selection can be used to isolate aminoacyl-tRNA synthetases that aminoacylate suppressor tRNAs with noncoded amino acids.
authors.affiliation: Johns Hopkins University, Department of Chemistry, 3400 N. Charles Street, Baltimore, MD 21218, USA.
authors.forename: Tamara L
authors.initials: TL
authors.lastname: Hendrickson
mesh_terms: D000596:Amino Acids / Q000096:biosynthesis / Q000235:genetics; D000604:Amino Acyl-tRNA Synthetases / Q000235:genetics* / Q000302:isolation & purification; D018388:Codon, Terminator / Q000737:chemistry / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics; D005815:Genetic Code; D016297:Mutagenesis, Site-Directed; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics; D013379:Substrate Specificity / Q000235:genetics
chemical_list: D000596:Amino Acids; D018388:Codon, Terminator; D011506:Proteins; D000604:Amino Acyl-tRNA Synthetases