title: Rapid decline in ovarian reserve after repeated ART cycles in a 22-year-old IVF patient.
abstract: OBJECTIVE
  The objective was to discuss the rapid decline in ovarian reserve due to repeated assisted reproductive technologies (ART) in a 22-year-old patient.
  
  
  METHODS
  This case report presents an infertile couple admitted to our IVF unit with the diagnosis of recurrent implantation failure and congenital uterine anomaly. Main outcome measures were the number of growing follicles and metaphase II oocytes retrieved.
  
  
  RESULTS
  After recurrent implantation failure of three in vitro fertilization cycles, the couple underwent three consecutive intracytoplasmic sperm injection cycles in our center. With a high number of oocytes retrieved, first cycle resulted in implantation failure followed by an embryo transfer cancelled cycle. The third cycle was cancelled due to an unexpected poor response even with the highest gonadotrophin dose.
  
  
  CONCLUSIONS
  Rapid decrease in ovarian reserve should be considered when offering repeated ART cycles even if the woman is very young and has a good ovarian reserve.
authors.affiliation: Antalya IVF Center, Halide Edip Cad No:7 Pil Fabrikasi Karşisi, 07080 Antalya, Turkey. misikoglu@hotmail.com
authors.forename: Mete
authors.initials: M
authors.lastname: Isikoglu
authors.forename: Kemal
authors.initials: K
authors.lastname: Ozgur
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology*; D008297:Male; D006080:Ovarian Follicle / Q000503:physiopathology*; D011247:Pregnancy; D019233:Retreatment; D020554:Sperm Injections, Intracytoplasmic; D014599:Uterus / Q000002:abnormalities