Protective effect of T-588 on toxic damage by serum deprivation and amyloid-beta protein in cultured neurons.
The present study examines the effect of the cognition enhancer (1R)-1-benzo[b]thiophen-5-yl-2-[2-(diethylamino)ethoxy]ethan-1-ol hydrochloride (T-588) on neuronal injury induced by serum deprivation or amyloid-beta protein (A beta). T-588 protected partially against neuronal injury induced by serum deprivation or A beta in cultured cortical neurons. T-588 did not affect the phosphorylation of extracellular signal-regulated kinase (ERK) in cortical neurons and SH-SY5Y cells. These results suggest that T-588 has a protective effect in neuronal injury models and the effect is not mediated by an ERK signal pathway.
Yamamuro
Akiko
A
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University.
Ago
Yukio
Y
Maeda
Sadaaki
S
Sakai
Yoshiyuki
Y
Baba
Akemichi
A
Matsuda
Toshio
T
D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D016895:Culture Media, Serum-Free / Q000494:pharmacology; D004048:Diethylamines / Q000494:pharmacology*; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010446:Peptide Fragments / Q000633:toxicity*; D051381:Rats; D013876:Thiophenes / Q000494:pharmacology*
D016229:Amyloid beta-Peptides; D016895:Culture Media, Serum-Free; D004048:Diethylamines; D018696:Neuroprotective Agents; D010446:Peptide Fragments; D013876:Thiophenes; C074636:amyloid beta-protein (25-35); C082372:T 588; D020928:Mitogen-Activated Protein Kinases