From subgenome analysis to protein structure.
Groups of related genes abound in large eukaryotic genomes. In such 'subgenomes', homology modeling carried out for a few genes will probably have relevance to the entire group. Subgenomes also afford unique ways of determining protein structural information. In addition to analyses based on the quantification of residue variability in paralogs, two-way comparisons, both within and among species, help to disclose functional amino acids. Comparative studies of gene families throughout the mammalian genome will also help elucidate the functional significance of single nucleotide polymorphisms in coding regions.
Man
Orna
O
The Crown Human Genome Center, The Weizmann Institute of Science, Rehovot, 76100, Israel.
Atarot
Tal
T
Sadot
Avital
A
Olender
Tsviya
T
Lancet
Doron
D
D000818:Animals; D001665:Binding Sites; D016000:Cluster Analysis; D017124:Conserved Sequence; D006801:Humans; D008322:Mammals / Q000235:genetics; D005810:Multigene Family / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018035:Receptors, Odorant / Q000235:genetics*; D017385:Sequence Homology; D026801:Synteny
D018035:Receptors, Odorant