Review of the properties and mechanisms of action of cyclosporine with an emphasis on dermatological therapy in dogs, cats and people.
Cyclosporine is being increasingly used in veterinary medicine. It is a potent suppressor of T cell induction and proliferation, and has a wide variety of anti-inflammatory and antiproliferative effects, downregulating effects on antigen presentation, and variable effects on parasites. This paper reviews its properties and mechanisms of action with particular reference to its use in the treatment of dermatological conditions in dogs, cats and people.
Robson
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Melbourne Veterinary Referral Centre, 70 Blackburn Road, Glen Waverley, Victoria 3150, Australia.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D017951:Antigen Presentation; D002455:Cell Division / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy* / Q000662:veterinary*
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine