title: Fatal thrombocytopenia and thrombocytopathia: an unusual onset of non-small cell lung cancer.
abstract: BACKGROUND
  Although bone marrow is a common site of micrometastases for non-small cell lung cancer (NSCLC), thrombocytopathia and hemorrhagic diathesis are rare causes of death.
  
  
  METHODS
  A 57-year-old patient was admitted to the emergency room because of massive nosebleeding and hemoptysis. Routine blood analysis showed thrombocytopenia and prolonged bleeding time; results of functional platelet tests suggested concomitant thrombocytopathia. Routine chest X-ray revealed an 18 mm large spot in the right superior lobe. During the first hour of recovery the patient had another episode of nosebleeding. A bone marrow biopsy showed a wide infiltration with neoplastic cells. Histology was compatible with NSCLC. The clinical conditions and hematological parameters progressively deteriorated, and on the third day the patient died because of hypovolemic shock.
  
  
  CONCLUSIONS
  This is a very rare clinical presentation of NSCLC characterized by massive bleeding due to thrombocytopenia and thrombocytopathia secondary to wide bone marrow infiltration.
authors.affiliation: Oncology Department, Campus Bio-Medico University, Rome, Italy. g.tonini@unicampus.it
authors.forename: G
authors.initials: G
authors.lastname: Tonini
authors.forename: B
authors.initials: B
authors.lastname: Vincenzi
authors.forename: S
authors.initials: S
authors.lastname: Di Cosimo
authors.forename: G
authors.initials: G
authors.lastname: Gravante
authors.forename: D
authors.initials: D
authors.lastname: Santini
authors.forename: V
authors.initials: V
authors.lastname: Ambrogi
authors.forename: E
authors.initials: E
authors.lastname: Micheletti
authors.forename: L
authors.initials: L
authors.lastname: Rocci
authors.forename: M
authors.initials: M
authors.lastname: D'Aprile
mesh_terms: D001706:Biopsy; D001791:Blood Platelet Disorders / Q000209:etiology* / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D019046:Bone Marrow Neoplasms / Q000473:pathology / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary; D004844:Epistaxis / Q000209:etiology / Q000473:pathology; D017809:Fatal Outcome; D006469:Hemoptysis / Q000209:etiology / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000473:pathology; D013921:Thrombocytopenia / Q000209:etiology* / Q000473:pathology