DNA probability profiles: examples from the Treponema pallidum genome.
In this paper we apply an algorithm developed by Poland (Biopolymers 13 (1974) 1859) to treat the statistical mechanics of the thermal unwinding of DNA to the genome of Treponema pallidum, the syphilis spirochete. We calculate probability profiles (giving the probability that each unit in the molecule is in the helix-state) and other statistical distributions for genes and sequences of genes, the longest containing 100 genes and 107,139 base pairs (approximately 10% of the genome).
Poland
Douglas
D
Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA. poland@jhu.edu
D000465:Algorithms; D016172:DNA Fingerprinting; D016678:Genome; D011336:Probability; D013223:Statistics as Topic; D013816:Thermodynamics; D014210:Treponema pallidum / Q000235:genetics*