title: The microbiological transformation of the diterpenes dehydroabietanol and teideadiol by Mucor plumbeus.
abstract: The microbiological transformation of dehydroabietanol (18-hydroxy-dehydroabietane) by Mucor plumbeus led to 2alpha,18-dihydroxy-abieta-8,11,13,15-tetraene, 2alpha,15-dihydroxy-dehydroabietanol, 2alpha-hydroxy-15-methoxy-dehydroabietanol, 7beta-hydroxy-2-oxo-dehydroabietanol, 15-hydroxy-2-oxo-dehydroabietanol and 15,16-dihydroxy-2-oxo-dehydroabietanol, whilst that of teideadiol (1alpha,18-dihydroxy-dehydroabietane) gave 2alpha-hydroxy-teideadiol, 7alpha-hydroxy-teideadiol and 7beta-hydroxy-teideadiol. Thus, 2alpha- and 7beta-hydroxylation occur in both biotransformations and the 15-hydroxylation is inhibited in the biotransformation of teideadiol by the presence of a 1alpha-alcohol.
authors.affiliation: Instituto de Productos Naturales y Agrobiología, CSIC, Avda. Astrofísico F. Sánchez 3, La Laguna, 38206-Tenerife, Canary Islands, Spain. bmfraga@ipna.csic.es
authors.forename: Braulio M
authors.initials: BM
authors.lastname: Fraga
authors.forename: Melchor G
authors.initials: MG
authors.lastname: Hernández
authors.forename: Jose M
authors.initials: JM
authors.lastname: Artega
authors.forename: Sergio
authors.initials: S
authors.lastname: Suárez
mesh_terms: D045784:Abietanes; D001711:Biotransformation; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism*; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism*
chemical_list: D045784:Abietanes; D004224:Diterpenes; C477324:teideadiol; C465098:dehydroabietinol