The mitochondrial battlefield and membrane lipids during cell death signalling.
This brief review focuses on current issues regarding the biochemical understanding of key reactions in the mitochondrial membrane damage induced by apoptosis signalling, especially in the pathway followed by death receptors in primary tissues. An overview of the emerging role of cardiolipin in apoptosis is also presented, discussing controversial issues and future directions of research. In addition, it is suggested that pro-apoptotic Bid may modulate key processes linking lipid constituents of mitochondrial membranes to lipid re-modelling that are altered early by death receptor signalling.
Degli Esposti
Mauro
M
Cancer Research UK Molecular Pharmacology Group, School of Biological Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK. mauro1it@hotmail.com
D000818:Animals; D017209:Apoptosis; D051023:BH3 Interacting Domain Death Agonist Protein; D002308:Cardiolipins / Q000502:physiology; D002352:Carrier Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D050356:Lipid Metabolism; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D015398:Signal Transduction; D010738:Type C Phospholipases / Q000378:metabolism
D051023:BH3 Interacting Domain Death Agonist Protein; D002308:Cardiolipins; D002352:Carrier Proteins; D010738:Type C Phospholipases