title: Relationship between aortic-to-radial arterial pressure gradient after cardiopulmonary bypass and changes in arterial elasticity.
abstract: BACKGROUND
  An aortic-to-radial arterial pressure gradient may develop during and after cardiopulmonary bypass (CPB). The mechanisms of this pressure gradient remain controversial. To clarify the cause of the pressure gradient after CPB, the authors investigated the relationship between the pressure gradient and changes in the pulse wave velocity (PWV) before and after CPB.
  
  
  METHODS
  The pressure gradient from the aorta to the radial artery and a change in PWV were measured with a wire (0.37 mm in diameter) tipped with a miniature pressure transducer in 12 patients undergoing cardiac surgery. The pressure distributions and waveforms were measured and recorded with electrocardiograph. The PWV was calculated by measuring the propagation time between the R wave of the electrocardiograph and the rising point of the arterial pressure waveform at 10-cm intervals.
  
  
  RESULTS
  After CPB, 7 of 12 patients demonstrated a marked pressure gradient. In these patients, the pressure distribution showed a gradual decrease toward the periphery without a precipitous step-down in pressure at any one specific anatomic location. The PWV decreased as the intraarterial pressure decreased from the aorta to the radial artery, and the relative arterial elasticity decreased linearly toward the periphery.
  
  
  CONCLUSIONS
  The results showed that the decrease in PWV implies a decrease in arterial elasticity, and the decrease in the arterial elasticity correlated with the decrease in intraarterial pressure. These findings demonstrated that a radial artery pressure lower than the aortic pressure after CPB may be due to the decrease in arterial elasticity.
authors.affiliation: Department of Anesthesiology, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan. masa@webscopy.com
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kanazawa
authors.forename: Haruo
authors.initials: H
authors.lastname: Fukuyama
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kinefuchi
authors.forename: Mamoru
authors.initials: M
authors.lastname: Takiguchi
authors.forename: Toshiyasu
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000328:Adult; D000368:Aged; D001011:Aorta / Q000502:physiology; D001158:Arteries / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D002302:Cardiac Output / Q000502:physiology; D002315:Cardiopulmonary Bypass; D004548:Elasticity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017534:Radial Artery / Q000502:physiology*