Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XVI. Derivatives of 1-acetoxy-7,7-dimethylbicyclo[2.2.2]octan-5-one-2,3-dicarboximide.
The preparation of a potential anxiety-relieving compounds N-[4-(4-aryl)-1-piperazinyl)butyl]-1-acetoxy-7,7-dimethyl-bicyclo[2.2.2]octan-5-one-2,3-dicarboximides has been described. N-[4-(4-2-methoxyphenyl)-1-piperazinyl)butyl]-1-acetoxy-7,7-dimethyl-bicyclo[2.2.2]octan-5-one-2,3-dicarboximide III showed a strong sedative effect in Writh's test.
Kossakowski
Jerzy
J
Department of Medical Chemistry, Medical University, 3 Oczki Str., 02-007 Warsaw, Poland. jerzykoss@hotmail.com
Hejchman
Elzbieta
E
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000494:pharmacology*; D003220:Conflict, Psychological; D007094:Imides / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D044263:Receptors, Serotonin, 5-HT1; D013055:Spectrophotometry, Infrared
D014151:Anti-Anxiety Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007094:Imides; D007202:Indicators and Reagents; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1