title: Effect of vitamin C and E supplementation in modulating the peripheral nerve conduction following cold exposure in humans.
abstract: Exposure to an extremely cold environment without proper protection leading to hypothermia is an emergency, one of the several complications of which is impairment in nerve conduction. Our previous work in the rat model has shown the beneficial effect of vitamin C in modulating the effect of hypothermia on nerve conduction. The present study aimed to evaluate the effect of vitamins C and E, administered alone or in combination, in modulating the effect of mild hypothermia on human ulnar nerve conduction. The study was carried out on 26 volunteers divided into three groups: group I received vitamin C supplementation (2000 mg/day in a single dose and 1,000 mg/day for the next 6 days), group II received vitamins C and E in combination (1,000 mg and 800 mg respectively in a single dose and 500 mg and 400 mg respectively for the next 6 days) and group III received vitamin E (800 mg in a single dose and the same for the next 6 days). The recordings were carried out before and after single and weekly supplementation in each group. There was a fall in ulnar nerve conduction velocity with a reduction in the oral temperature of 2-2.5 degrees C. Vitamin C administered alone and in combination with vitamin E reduced the fall in ulnar nerve conduction velocity. Prior supplementation with vitamin C and E could help ameliorate the impairment in human ulnar nerve conduction due to hypothermia.
authors.affiliation: Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi-110054, India.
authors.forename: Usha
authors.initials: U
authors.lastname: Panjwani
authors.forename: Deepak K
authors.initials: DK
authors.lastname: Yadav
authors.forename: Amitabh
authors.initials: A
authors.lastname: Kumar
authors.forename: S B
authors.initials: SB
authors.lastname: Singh
authors.forename: W
authors.initials: W
authors.lastname: Selvamurthy
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage*; D003081:Cold Climate / Q000009:adverse effects; D004311:Double-Blind Method; D006801:Humans; D007035:Hypothermia / Q000188:drug therapy* / Q000503:physiopathology* / Q000517:prevention & control; D008297:Male; D009431:Neural Conduction / Q000187:drug effects*; D014459:Ulnar Nerve / Q000187:drug effects / Q000503:physiopathology; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D014810:Vitamin E; D001205:Ascorbic Acid