Synthesis of isochrysohermidin-distamycin hybrids.
The synthesis of the alkylating subunit of the DNA cross-linking agent, isochrysohermidin (2), and its subsequent incorporation into conjugates with distamycin A (1) are described. The DNA binding properties of these agents were compared to that of distamycin A, using a fluorescence intercalator displacement (FID) assay.
Yeung
Bryan K S
BK
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Boger
Dale L
DL
D000465:Algorithms; D000478:Alkylation; D020650:Combinatorial Chemistry Techniques; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004214:Distamycins / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D003432:Cross-Linking Reagents; D004214:Distamycins; C030000:stallimycin; D004247:DNA