[The clinical significance of SSA antigen and its different positive expressions].
OBJECTIVE
To distinguish the difference among the pathogenesis of 60 000 SSA antigen mono-antigen peptides (MAPs), and to discuss the nosogenesis of anti-60 000 SSA antibodies in correlative rheumatic diseases.


METHODS
MAPs were artificially synthesized according to the amino acid sequence of 20 positive epitopes and 1 control segment of 60 000 SSA antigen. ELISA against recombinant 60 000 SSA antigen MAPs were done to detect anti-MAPs antibodies in 59 sera with anti-SSA antibodies, and analyzing the relations of anti-MAPs antibodies and organism injuries.


RESULTS
Anti-60 000 SSA antibodies are multiple clone autoantibodies. Different patients have different immune response to MAPs. Anti-MAP(1 approximately 21) antibodies have no relation to skin lesion; anti-MAP(2,14,15,21) antibodies have positive relation to salivary gland lesion; anti-MAP(7,16) antibodies have negative relation to kidney lesion; anti-MAP(6) antibodies have negative relation to heart lesion.


CONCLUSIONS
The appearance of some anti-MAPs antibodies implies the lesions of some organs, while the appearance of some other anti-MAPs antibodies have the protection to some organs. We concluded that it is maybe the different anti-MAPs antibodies that result in different clinical manifestations.
Li
Ya-jie
YJ
Department of Rheumatology and Immunology, Union Hospital of Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China. zhangsamfc@fm365.com
Liu
Li
L
Zhang
Feng-chun
FC
D000974:Antibodies, Antinuclear / Q000276:immunology; D000937:Antigen-Antibody Reactions; D000939:Epitopes / Q000276:immunology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D012216:Rheumatic Diseases / Q000276:immunology; D012261:Ribonucleoproteins / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000276:immunology; D000099207:SS-A Antigen
D000974:Antibodies, Antinuclear; D000939:Epitopes; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C035356:SS-A antibodies