title: Two unusual acetogenins from the roots of Annona salzmanii.
abstract: Two new acetogenins, parisin (1) and salzmanolin (2), were isolated from a MeOH extract of the roots of Annona salzmanii. The structures of 1 and 2 were elucidated by spectroscopic methods including LSI-MS/MS, on both the natural compounds and their acetonide derivatives (1a and 2a). Compounds 1 and 2 showed significant activity against the KB and Vero cell lines.
authors.affiliation: Laboratoire de Pharmacognosie, CNRS UPRES-A 8076 (BIOCIS), Faculté de Pharmacie, 92296 Châtenay-Malabry, France. Emerson.ferreiraqueiroz@ipp.unil.ch
authors.forename: Emerson F
authors.initials: EF
authors.lastname: Queiroz
authors.forename: François
authors.initials: F
authors.lastname: Roblot
authors.forename: Olivier
authors.initials: O
authors.lastname: Laprévote
authors.forename: Marçal de Q
authors.initials: Mde Q
authors.lastname: Paulo
authors.forename: Reynald
authors.initials: R
authors.lastname: Hocquemiller
mesh_terms: D000818:Animals; D031041:Annona / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014709:Vero Cells
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; C478443:parisin; C478444:salzamanolin