title: Excessive alcohol intake enhances the development of synchronous cancerous lesion in colorectal cancer patients.
abstract: OBJECTIVE
  We examined the potential impact of alcohol drinking on the incidence of synchronous colorectal cancer.
  
  
  METHODS
  This study comprised 191 men with colorectal cancer who had undergone surgical resection. Synchronous colorectal cancer was found in 16 patients (8.4%). The relationship between synchronous colorectal cancer and alcohol intake was analyzed by multivariate methods. Cumulative alcohol intake was assessed by the drinking index (weekly average multiplied by years of drinking).
  
  
  RESULTS
  There was higher incidence of associated adenoma in the synchronous cancer group. Heavy cumulative intake (drinking index 9800 or higher) was associated with significantly higher risk synchronous colorectal cancer than in nondrinkers (odds ratio 6.8). The association of alcohol intake with the risk of synchronous colorectal cancer was not affected by the type of alcohol beverages.
  
  
  CONCLUSIONS
  This study demonstrated that excessive alcohol intake might be an independent risk factor for synchronous colorectal cancer. The screening program based on this information may prevent the synchronous lesions being missed.
authors.affiliation: Division of Diabetes, Digestive, and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Hyogo, 650-0017 Kobe, Japan.
authors.forename: Shu-ji
authors.initials: SJ
authors.lastname: Maekawa
authors.forename: Nobuo
authors.initials: N
authors.lastname: Aoyama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Shirasaka
authors.forename: Kohei
authors.initials: K
authors.lastname: Kuroda
authors.forename: Takao
authors.initials: T
authors.lastname: Tamura
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Masato
authors.initials: M
authors.lastname: Kasuga
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000473:pathology; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D000437:Alcoholism / Q000150:complications*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009378:Neoplasms, Multiple Primary / Q000209:etiology* / Q000473:pathology; D016017:Odds Ratio; D012307:Risk Factors