Combined protective effect of a fungal Cu/Zn-containing superoxide dismutase and rimantadine hydrochloride in experimental murine influenza a virus infection.
The combined protective effect of a novel naturally glycosylated Cu/Zn-containing superoxide dismutase, produced by the fungus Humicula lutea (HL-SOD) strain 103, and the selective anti-influenza drug rimantadine hydrochloride (Rim) was evaluated in experimental virus infection in mice, induced with influenza virus A/Aichi/2/68 (H3N2). A combined application of HL-SOD and Rim in doses, which by themselves did not protect significantly mice against the infection, resulted in a synergistically increased protection, determined on the basis of protective indices. Lung virus titers, lung weights and consolidation and mortality rates were all decreased significantly, while survival times were prolonged.
Serkedjieva
J
J
Institute of Microbiology, Bulgarian Academy of Sciences, 26 Acad. G. Bonchev Str., 1113 Sofia, Bulgaria. jserkedjieva@microbio.bas.bg
Roeva
I
I
Angelova
M
M
Dolashka
P
P
Voelter
W G
WG
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D007611:Aprotinin / Q000627:therapeutic use; D003300:Copper / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D008168:Lung / Q000473:pathology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D012299:Rimantadine / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000494:pharmacology / Q000627:therapeutic use*; D015032:Zinc / Q000494:pharmacology
D000998:Antiviral Agents; D012299:Rimantadine; D003300:Copper; D007611:Aprotinin; D013482:Superoxide Dismutase; D015032:Zinc