Molecular cloning and characterization of human RAI1, a gene associated with schizophrenia.
Schizophrenia is a common neuropsychiatric disorder of uncertain etiology that is believed to result from the interaction of environmental factors and multiple genes. To identify new genes predisposing to schizophrenia, numerous groups have focused on CAG-repeat-containing genes. We previously reported a CAG repeat polymorphism that was shown to be associated with both the severity of the phenotype and the response to medication in schizophrenic patients. In this article, we now report the genomic structure of this gene, the retinoic acid inducible-1 gene (RAI1), and present its characterization. This gene, located on chromosome 17p11.2, comprises six exons coding for a 7.6-kb mRNA. The RAI1 gene is highly homologous to its mouse counterpart and it is expressed at high levels mainly in neuronal tissues.
Toulouse
André
A
Centre for Research in Neuroscience, McGill University and the McGill University Health Centre Research Institute, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4. andre.toulouse@staff.mcgill.ca
Rochefort
Daniel
D
Roussel
Julie
J
Joober
Ridha
R
Rouleau
Guy A
GA
D000595:Amino Acid Sequence; D001483:Base Sequence; D015152:Blotting, Northern; D015139:Blotting, Southern; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D017931:DNA Primers; D018076:DNA, Complementary / Q000235:genetics; D040461:Gene Components / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D015534:Trans-Activators; D014157:Transcription Factors
D017931:DNA Primers; D018076:DNA, Complementary; D011506:Proteins; C431552:RAI1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors