title: Regeneration: every clot has a thrombin lining.
abstract: Why do some amphibian organs regenerate and others do not? And why do most mammalian organs not regenerate? New work on lens regeneration indicates that the answer lies in the need for cells to dedifferentiate first, and that what makes them dedifferentiate may be the presence of thrombin in combination with cellular clotting factors.
authors.affiliation: MRC Centre for Developmental Neurobiology, New Hunt's House, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK.
authors.forename: Malcolm
authors.initials: M
authors.lastname: Maden
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D007908:Lens, Crystalline / Q000166:cytology / Q000502:physiology*; D008954:Models, Biological; D012038:Regeneration / Q000502:physiology*; D016160:Retinoblastoma Protein / Q000378:metabolism; D013917:Thrombin / Q000378:metabolism*; D014562:Caudata / Q000378:metabolism / Q000502:physiology*
chemical_list: D016160:Retinoblastoma Protein; D013917:Thrombin