title: Acute metabolic effects of thiopental anesthesia on fed and fasted rats chronically treated with bromocriptine.
abstract: We investigated the acute effects of thiopental anesthesia (4 mg/100 g, i.v.) on plasma glucose, insulin, triacylglycerol, and prolactin levels in rats treated with bromocriptine (BR) (0.4 mg/100 g body wt, i.p., for two weeks). Thiopental anesthesia induced a rapid increase in plasma insulin that was more pronounced in the animals treated with BR (116%, P <0.05). Thiopental anesthesia also produced a 55% decreased in plasma prolactin levels (P <0.01) in control fed rats, and a 22% reduction in plasma triacylglycerol (P <0.05) in both controls and BR-treated rats. We conclude that BR may constitute and additional sympatholytic factor in animals submitted to thiopental anesthesia.
authors.affiliation: Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil.
authors.forename: Antônio Ribeiro
authors.initials: AR
authors.lastname: de Oliveira
authors.forename: Leida Maria
authors.initials: LM
authors.lastname: Botion
authors.forename: Rachel Menezes
authors.initials: RM
authors.lastname: Guerra
authors.forename: Rodrigo Bastos
authors.initials: RB
authors.lastname: Fóscolo
authors.forename: Lucas José Campos
authors.initials: LJ
authors.lastname: Machado
authors.forename: Umeko
authors.initials: U
authors.lastname: Marubayashi
authors.forename: Adelina Martha
authors.initials: AM
authors.lastname: dos Reis
authors.forename: Cândido Celso
authors.initials: CC
authors.lastname: Coimbra
mesh_terms: D000758:Anesthesia / Q000379:methods*; D018686:Anesthetics, Intravenous; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001971:Bromocriptine / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005215:Fasting / Q000097:blood*; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D007328:Insulin / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013874:Thiopental
chemical_list: D018686:Anesthetics, Intravenous; D001786:Blood Glucose; D007328:Insulin; D001971:Bromocriptine; D011388:Prolactin; D013874:Thiopental