[Successful treatment of Echovirus 27 meningoencephalitis in agammaglobulinaemia with intraventricular injection of gammaglobulin. A case report].
BACKGROUND
Meningoencephalitis due to enteroviruses is particularly serious when occurring in patients with agammaglobulinaemia. This disease is associated with a high mortality and a significant risk for neurological sequelae in such circumstances. We report here a new case treated with intraventricular immunoglobulin, whose evolution was favourable.


METHODS
A three-year-old boy with agammaglobulinaemia, while he was treated with gammaglobulin with an IgG residual concentration of 10 g/l, presented neurological symptoms related to Echovirus 27 meningo encephalitis. Under treatment with intraventricular gammaglobulin by means of an Ommaya reservoir, the patient recovered.


CONCLUSIONS
Favourable evolution is rare in meningo encephalitis in agammaglobulinaemic patients. Prognosis depends on an early diagnosis and on the extent of dissemination of the infection. Intraventricular gammaglobulin administration may contribute to a favourable outcome.
Mellouli
F
F
Centre national de greffe de moelle osseuse, 6, rue Djebel-Lakhdhar, 1006 Bab Saadoun, Tunis, Tunisie.
Arrouji
Z
Z
Debre
M
M
Bejaoui
M
M
D002675:Child, Preschool; D004769:Enterovirus Infections / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D007116:Immunization, Passive; D008297:Male; D008590:Meningoencephalitis / Q000188:drug therapy* / Q000821:virology*; D011379:Prognosis; D016896:Treatment Outcome; D005719:gamma-Globulins / Q000494:pharmacology*
D005719:gamma-Globulins