title: Severe methylenetetrahydrofolate reductase deficiency, methionine synthase, and nitrous oxide--a cautionary tale.
authors.affiliation: Department of Pediatrics, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
authors.forename: Richard W
authors.initials: RW
authors.lastname: Erbe
authors.forename: Robbert J
authors.initials: RJ
authors.lastname: Salis
mesh_terms: D045103:5,10-Methylenetetrahydrofolate Reductase (FADH2); D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000187:drug effects*; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D005492:Folic Acid / Q000378:metabolism; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D008661:Metabolism, Inborn Errors / Q000175:diagnosis* / Q000235:genetics; D008715:Methionine / Q000097:blood; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D009609:Nitrous Oxide / Q000009:adverse effects*; D010088:Oxidoreductases / Q000172:deficiency* / Q000235:genetics; D017354:Point Mutation
chemical_list: D018685:Anesthetics, Inhalation; D006710:Homocysteine; D005492:Folic Acid; D008715:Methionine; D010088:Oxidoreductases; D045103:5,10-Methylenetetrahydrofolate Reductase (FADH2); D042965:Methylenetetrahydrofolate Reductase (NADPH2); D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; D009609:Nitrous Oxide