DNA damage effects of hydroxyapatite ultrofine powder on W-256 sarcoma cells and lymphocytes in rats.
To explore the anticancer mechanism and DNA damages of hydroxyapatite ultrofine powder (HAUFP) on lymphocytes of rats, DNA damages in W-256 sarcoma cells and lymphocytes of rats were measured by single cell gel electrophoresis (SCGE). The results showed that HAUFP damaged DNA of W-256 sarcoma cells obviously but only cause slight damage of DNA of lymphocytes in rats. It is suggested that HAUFP selectively damaged DNA of tumor cells with only mild damage of lymphocyte DNA. HAUFP has powerful anticancer effect and little genetic toxicity.
Xia
Q
Q
Department of General Surgery, Xiehe Hospital, Tongji Medical University, Wuhan 430022.
Hu
P
P
Chen
D
D
Zhang
J
J
Tian
Y
Y
Zhang
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002279:Carcinoma 256, Walker / Q000235:genetics / Q000473:pathology*; D020552:Comet Assay; D004249:DNA Damage / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000187:drug effects; D017886:Durapatite / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D008214:Lymphocytes / Q000473:pathology; D011208:Powders; D051381:Rats; D017208:Rats, Wistar
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D011208:Powders; D017886:Durapatite