Large stabilization of a DNA duplex by the deoxyadenosine derivatives tethering an aromatic hydrocarbon group.
Novel deoxyadenosine derivatives tethering a phenyl or naphthyl group by means of an amido linker have been synthesized, and these derivatives, stacking on the 5' end of a DNA duplex, provide free energy contributions equal to or greater than that of the Watson-Crick A/T base pair.
Nakano
Shu-ichi
S
High Technology Research Center and Department of Chemistry, Faculty of Science and Engineering, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan.
Uotani
Yuuki
Y
Nakashima
Shoji
S
Anno
Yosuke
Y
Fujii
Masayuki
M
Sugimoto
Naoki
N
D004247:DNA / Q000737:chemistry*; D018076:DNA, Complementary / Q000737:chemistry; D003839:Deoxyadenosines / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D009284:Naphthols / Q000138:chemical synthesis / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D010671:Phenylurea Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013816:Thermodynamics
D018076:DNA, Complementary; D003839:Deoxyadenosines; D006841:Hydrocarbons, Aromatic; D009284:Naphthols; D009841:Oligonucleotides; D010671:Phenylurea Compounds; D004247:DNA