Direct electrophilic diamination of functionalized alkenes without the use of any metal catalysts.
A new direct electrophilic diamination reaction of alpha,beta-unsaturated ketones and esters has been established without the use of any metal catalysts. Three types of nitriles (CH(3)CN, CH(3)CH(2)CN, and CH(3)CH(2)CH(2)CN) were employed as nucleophilic nitrogen sources. A new mechanism has also been proposed to explain the resulting regio- and stereoselectivity.
Chen
Dianjun
D
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061, USA.
Timmons
Cody
C
Wei
Han-Xun
HX
Li
Guigen
G
D000475:Alkenes / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003959:Diamines / Q000737:chemistry*; D004952:Esters / Q000737:chemistry; D007659:Ketones; D009570:Nitriles / Q000737:chemistry
D000475:Alkenes; D003959:Diamines; D004952:Esters; D007659:Ketones; D009570:Nitriles