[Changes in interleukin-1beta in serum and bronchoalveolar lavage fluid in the patient with acute respiratory distress syndrome].
OBJECTIVE
To study the role of interleukin-1beta (IL-1beta) in the pathogenesis of acute respiratory distress syndrome (ARDS).


METHODS
The bronchoalveolar lavage fluid (BALF) and serum in 13 patients with ARDS and 9 healthy controls were collected. The contents of IL-1beta were measured by enzyme-linked immunoadsorbent assay(ELISA).


RESULTS
The levels of IL-1beta in BALF [(144.67+/-80.79)ng/L] and serum [(45.71+/-7.09)ng/L] in patients with ARDS were significantly higher than those in the control groups [(20.39+/-1.87)ng/L, P=0.000; (35.06+/-5.46)ng/L, P=0.001, respectively], and the levels of IL-1beta in BALF were also significantly higher than those of the serum in the patients with ARDS (P=0.000).


CONCLUSIONS
The results indicate that IL-1beta is involved in the pathogenesis of ARDS. Early determination of IL-1beta level in BALF may be more valuable in the evaluation of disease process of ARDS.
Luo
Xian-rong
XR
Department of Respiratory Disease, Airforce Hospital of People's Liberation Army, Guangzhou, 510602 Guangdong, China.
Wu
Wei-ling
WL
Wang
Lin
L
Ye
Xiao-qun
XQ
Zhang
Dan
D
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007375:Interleukin-1 / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000378:metabolism / Q000473:pathology*
D007375:Interleukin-1