title: [New concepts in hyperactive malarial splenomegaly].
abstract: Hyperreactive malarial splenomegaly is thought to represent an immunological dysfunction due to recurrent episodes of malaria. The authors present a case of hyperreactive malarial splenomegaly in a patient from São Tomé e Príncipe and discuss aspects of its differential diagnosis and treatment. A revision is made of recent concepts related to its pathogenesis and relationship with lymphoproliferative disorders. Malarial DNA was found in the absence of parasite forms in the peripheral blood. This may indicate that latent infection plays a role in its pathogenesis.
authors.affiliation: Serviço de Medicina II, Hospital de Egas Moniz, Instituto de Higiene e Medicina Tropical, Lisboa.
authors.forename: M F
authors.initials: MF
authors.lastname: Moraes
authors.forename: M
authors.initials: M
authors.lastname: Soares
authors.forename: M J
authors.initials: MJ
authors.lastname: Arroz
authors.forename: V E
authors.initials: VE
authors.lastname: Do Rosário
authors.forename: J Pimenta
authors.initials: JP
authors.lastname: Da Graça
authors.forename: P
authors.initials: P
authors.lastname: Abecasis
mesh_terms: D016054:DNA, Protozoan / Q000097:blood / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000188:drug therapy; D008288:Malaria / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D012008:Recurrence; D013163:Splenomegaly / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D016054:DNA, Protozoan