Synthesis and luminescence studies of aryl substituted tetraamide complexes of europium(III): a new approach to pH responsive luminescent europium probes.
DOTA-tetraamide ligands having extended phenol or pyridine substituents have been synthesized. The (5)D(0) --> (7)F(J) deltaJ = 1 and 2 emission bands in the corresponding europium(III) complexes differ in their sensitivity to solution pH. This offers the potential for developing pH responsive probes for in vivo imaging that are independent of probe concentration.
Woods
Mark
M
Department of Chemistry, University of Texas at Dallas, Richardson, Texas 75083, and Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, Texas 75235, USA.
Sherry
A Dean
AD
D004396:Coloring Agents / Q000737:chemistry*; D004563:Electrochemistry; D005063:Europium / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D008024:Ligands; D049449:Luminescence; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D012997:Solvents
D004396:Coloring Agents; D007202:Indicators and Reagents; D008024:Ligands; D012997:Solvents; D005063:Europium