Synthesis and biological action of 3-R-4-substituted-delta2-1,2,4-triazoline-5-thione.
In the reaction of hydroiodide of methyl ester of 3-thiocarbazic acid with diethylamine and morpholine hydroiodide of 2-amino-1-substituted-guanidine [I-II] were obtained. These compounds were then converted to respective 3-R-4-substituted-delta2-1,2,4-triazoline-5-thione [III-X] in the reaction with isothiocyanates. Some of these compounds were screened for their antibacterial activities.
Dobosz
Maria
M
Department of Organic Chemistry, Faculty of Pharmacy, Medical University, 6 Staszica Str., 20-081 Lublin.
Wujec
Monika
M
Waśko
Adam
A
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013871:Thiones; D014230:Triazoles