Fluticasone-associated cutaneous allergic granulomatous vasculitis.
Allergic granulomatous vasculitis, or Churg-Strauss syndrome, is a small-vessel, multisystem vasculitis that can affect the skin, lungs, heart, and nervous system. Recent reports have implicated leukotriene receptor antagonists and inhaled corticosteroids in the development of this rare syndrome. We present a patient with no history of allergic asthma who acutely developed skin-limited Churg-Strauss-like granulomatous vasculitis after initiating therapy with inhaled fluticasone and salmeterol (Advair Diskus).
English
Joseph
J
University of Virginia, Department of Dermatology, Charlottesville, Virginia, USA. jce2n@Virginia.edu
Greer
Kenneth E
KE
McCrone
Sara A
SA
Patterson
James W
JW
VanLoock
J Scott
JS
D000730:Androstadienes / Q000009:adverse effects*; D015267:Churg-Strauss Syndrome / Q000139:chemically induced / Q000473:pathology; D000068298:Fluticasone; D006801:Humans; D008297:Male; D008875:Middle Aged; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000473:pathology*
D000730:Androstadienes; D000068298:Fluticasone