title: Antiviral activity of Inonotus hispidus.
abstract: The antiviral activity of two phenolic compounds, hispolon and hispidin, isolated from the fruit bodies of the basidiomycete Inonotus hispidus as well as of some extracts prepared from fruit bodies and mycelial cultures of this fungus was investigated in allantois on the shell-test system. Ethanolic extracts, hispidin and hispolon showed considerable antiviral activity against influenza viruses type A and B.
authors.affiliation: Institute of Pharmacy/Pharmaceutical Biology, Ernst-Moritz-Arndt University Greifswald, Friedrich-Ludwig-Jahn-Str 17, Greifswald 17487, Germany.
authors.forename: N A
authors.initials: NA
authors.lastname: Awadh Ali
authors.forename: R A A
authors.initials: RA
authors.lastname: Mothana
authors.forename: A
authors.initials: A
authors.lastname: Lesnau
authors.forename: H
authors.initials: H
authors.lastname: Pilgrim
authors.forename: U
authors.initials: U
authors.lastname: Lindequist
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001487:Basidiomycota; D002396:Catechols / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005638:Fruit; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects*; D009981:Influenza B virus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011753:Pyrones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D002396:Catechols; D010936:Plant Extracts; D011753:Pyrones; C103442:hispolon; C007946:hispidin