Effects of hypodynamia-hypokinesia on somatosensory evoked potentials in the rat.
The aim of this study was to determine if a prolonged period (7 or 14 days) of hypodynamia-hypokinesia (HH) affects the conduction of afferent input and the cortical and spinal responsiveness. Acute recordings of cortical and spinal somatosensory evoked potentials (SEPs) were performed after stimulation of the sciatic nerve in control rats and in rats submitted to 7 or 14 days of HH. HH was obtained by unloading the hindquarter. HH induced some subtle modifications in the SEP characteristics. Latency was increased for the spinal and cortical SEPs after 7 days of HH, and restored after 14 days of HH. A decrease in the amplitude was observed after 14 days of HH for the cortical SEP only. At the end of the experiment, the compound action potential of the sciatic nerve was recorded in vitro in order to evaluate the mean conduction velocity. Results indicate that the nerve velocity was reduced after 14 days of HH. The results also suggest that sensory conduction and/or cortical and spinal excitability are changed after HH.
Canu
Marie Hélène
MH
Laboratoire de Plasticité Neuromusculaire, EA 1032, IFR 118, Université des Sciences et Technologies de Lille, F-59655, Villeneuve d'Ascq, cedex, France. canu@univ-lille.1.fr
Langlet
Cécile
C
Dupont
Erwan
E
Falempin
Maurice
M
D000818:Animals; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D018476:Hypokinesia / Q000503:physiopathology*; D007103:Immobilization / Q000009:adverse effects / Q000502:physiology*; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time; D012584:Sciatic Nerve / Q000502:physiology; D013003:Somatosensory Cortex / Q000166:cytology / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology