title: Reaction of 7-(2-mesyloxy-2-phenylethyl)theophylline with amines: Synthesis of 1,2,3,6-tetrahydro-6-imino-2-oxo-7H-purine derivatives.
abstract: Theophylline was converted to 7-(2-phenyl-2-methanesulfonyloxy)ethyl congener and the product was treated with ammonia or primary amines in a mixture solution of water and organic solvents. Two products were proven to be the styrene analogue and 7-(2-amino-2-phenylethyl)theophylline. The structure of the third product was elucidated as the 1,2,3,6-tetrahydro-6-imino-2-oxo-7H-purine derivatives by spectroscopic analysis including HMBC correlation and X-ray crystallography.
authors.affiliation: Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kozai
authors.forename: K
authors.initials: K
authors.lastname: Ogimoto
authors.forename: H
authors.initials: H
authors.lastname: Okamoto
authors.forename: T
authors.initials: T
authors.lastname: Maruyama
mesh_terms: D000588:Amines / Q000737:chemistry*; D008698:Mesylates / Q000138:chemical synthesis* / Q000737:chemistry; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D013806:Theophylline / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C476352:7-(2-mesyloxy-2-phenylethyl)theophylline; D000588:Amines; D008698:Mesylates; D010726:Phosphodiesterase Inhibitors; D013806:Theophylline