title: EPO-producing gastric carcinoma in a hemodialysis patient.
abstract: A case of erythrocytosis caused by gastric cancer that produced erythropoietin is described. To the authors' knowledge, no case of erythropoietin-producing gastric cancer has been reported until now. A 73-year-old man with a 4-year history of maintenance hemodialysis for diabetic nephropathy required phlebotomy. Serum erythropoietin level was 181 mU/mL (181 IU/L). Gastroscopy results showed rough mucosa with hemorrhaging caused by gastric cancer. The patient underwent distal gastrectomy, and serum erythropoietin level decreased to 27.1 mU/mL (27.1 IU/L) by postoperative day 8. Existence of erythropoietin in the tumor tissue was confirmed immunohistochemically. The presence of severe acquired cystic disease of the kidney, renal cell carcinoma, and other malignant tumors should be investigated in hemodialysis patients displaying erythrocytosis.
authors.affiliation: Department of Urology, Nagasaki University School of Medicine, Nagasaki City, Japan. skoga@net.nagasaki-u.ac.jp
authors.forename: Manabu
authors.initials: M
authors.lastname: Matsuo
authors.forename: Shigehiko
authors.initials: S
authors.lastname: Koga
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kanetake
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohtani
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Higami
authors.forename: Isao
authors.initials: I
authors.lastname: Shimokawa
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Watanabe
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D000368:Aged; D003928:Diabetic Nephropathies / Q000150:complications / Q000628:therapy; D004921:Erythropoietin / Q000378:metabolism*; D005743:Gastrectomy; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006729:Hormones, Ectopic / Q000378:metabolism*; D006801:Humans; D008297:Male; D009384:Paraneoplastic Endocrine Syndromes / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D011086:Polycythemia / Q000209:etiology* / Q000503:physiopathology; D006435:Renal Dialysis; D013274:Stomach Neoplasms / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000601:surgery
chemical_list: D006729:Hormones, Ectopic; D004921:Erythropoietin