[Dapsone-induced sensory peripheral neuropathy].
BACKGROUND
Peripheral neuropathy is a rare complication of dapsone therapy.


METHODS
A 74 year-old woman was treated with dapsone, 50 mg per day, for a linear IgA dermatosis. One month later, the disease was controlled but the patient complained of a sensory peripheral neuropathy, which was documented on electromyographic studies. Dapsone was stopped and symptoms resolved within 24 hours. Three months after the beginning of linear IgA dermatosis, a colic adenocarcinoma was revealed by an acute occlusive syndrome. After surgical resection of the tumor, remission of linear IgA dermatosis was obtained with salazopyrine.


CONCLUSIONS
This is a rare side effect of dapsone therapy. Twenty-one cases have been previously reported. In most cases, there was a pure motor or mixed neuropathy. Dapsone therapy was then stopped or decreased. Recovery usually occurs within one year after dapsone therapy is discontinued.
Méry
L
L
Service de Dermatologie I, Hôpital Saint-Louis, 75010 Paris.
Dega
H
H
Prost
C
C
Dubertret
L
L
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000175:diagnosis; D003622:Dapsone / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D004576:Electromyography / Q000187:drug effects; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D009443:Neuritis / Q000139:chemically induced* / Q000175:diagnosis; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000188:drug therapy*; D012871:Skin Diseases / Q000175:diagnosis / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007070:Immunoglobulin A; D003622:Dapsone