Determination of pantoprazole by adsorptive stripping voltammetry at carbon paste electrode.
A voltammetric method was described for the determination of pantoprazole by differential-pulse adsorptive stripping voltammetry at a carbon paste electrode. Accumulation of pantoprazole was found to be optimized in Britton-Robinson buffer (0.04 M, pH 4.0) solution following 5 min accumulation time at open circuit condition. Under optimized conditions, the current showed a linear dependence with concentration in the range 1.0 x 10(-7)-1.0 x 10(-5) M. The detection limit was 2.0 x 10(-8) M. The method was applied successfully for the analysis of pantoprazole in tablet dosage form. The results of accuracy and precision were comparable to those obtained by spectrophotometry.
Radi
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Department of Chemistry, Faculty of Science, Mansoura University, 34517 Dumyat, Egypt. abradi@yahoo.com
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001562:Benzimidazoles / Q000032:analysis* / Q000378:metabolism; D002138:Calibration / Q000592:standards*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004563:Electrochemistry; D004566:Electrodes; D066298:In Vitro Techniques; D009853:Omeprazole / Q000031:analogs & derivatives; D000077402:Pantoprazole; D054328:Proton Pump Inhibitors; D017494:Proton Pumps / Q000032:analysis* / Q000378:metabolism; D013454:Sulfoxides / Q000032:analysis* / Q000378:metabolism
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001562:Benzimidazoles; D054328:Proton Pump Inhibitors; D017494:Proton Pumps; D013454:Sulfoxides; D000077402:Pantoprazole; D009853:Omeprazole