title: One-pot alpha-glycosylation method using Appel agents in N,N-dimethylformamide.
abstract: [reaction: see text] A concept for the development of practical glycosylation is presented and demonstrated by one-pot alpha-glycosylation applying Appel agents for 2-O-benzyl-1-OH hexoses in DMF. The reaction, in situ giving the equilibrium of glycosyl bromides and more reactive O-glycoside intermediates, accomplishes a near-quantitative alpha-glycosylation removing the water molecules.
authors.affiliation: Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan. nishida@mol.nagoya-u.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nishida
authors.forename: Yuko
authors.initials: Y
authors.lastname: Shingu
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Dohi
authors.forename: Kazukiyo
authors.initials: K
authors.lastname: Kobayashi
mesh_terms: D004126:Dimethylformamide / Q000737:chemistry*; D006031:Glycosylation
chemical_list: D004126:Dimethylformamide