Computational design strategies for combinatorial libraries.
Medicinal chemistry principles are being increasingly applied to the design of smaller, high purity, information-rich libraries. Recent computational advances in statistical methodology, the design of libraries to reduce ADMET problems, targeting protein families and revisiting natural products as sources of inspiration for scaffolds and reagents are all areas of progressive research.
Rose
Sally
S
BioFocus Discovery Ltd, Sittingbourne Research Centre, Sittingbourne, Kent ME9 8AZ, UK. srose@biofocus.co.uk
Stevens
Adrian
A
D000818:Animals; D001685:Biological Factors; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003627:Data Interpretation, Statistical; D015195:Drug Design; D006801:Humans; D019151:Peptide Library
D001685:Biological Factors; D019151:Peptide Library