title: Emergence of macrolide resistance in throat culture isolates of group a streptococci in Ontario, Canada, in 2001.
abstract: Of 500 group A streptococci isolated from pharyngeal swabs, 72 (14.4%) were macrolide resistant, compared to 2.1% in 1997. Of these, 66 (92%) were of the M phenotype and 6 (8.3%) were of the MLS phenotype. Pulsed-field gel electrophoresis found that two clones, with patterns identical to those of serotypes M1 and M4, accounted for 19.4 and 68.1% of the macrolide-resistant isolates, respectively.
authors.affiliation: Toronto Medical Laboratories/Mount Sinai Hospital Department of Microbiology. University of Toronto, Toronto, Ontario, Canada.
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Katz
authors.forename: Allison J
authors.initials: AJ
authors.lastname: McGeer
authors.forename: Carla L
authors.initials: CL
authors.lastname: Duncan
authors.forename: Aisha
authors.initials: A
authors.lastname: Ashi-Sulaiman
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Willey
authors.forename: Alicia
authors.initials: A
authors.lastname: Sarabia
authors.forename: Jacquie
authors.initials: J
authors.lastname: McCann
authors.forename: Sylvia
authors.initials: S
authors.lastname: Pong-Porter
authors.forename: Yana
authors.initials: Y
authors.lastname: Rzayev
authors.forename: Joyce S
authors.initials: JS
authors.lastname: de Azavedo
authors.forename: Donald E
authors.initials: DE
authors.lastname: Low
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D009864:Ontario / Q000453:epidemiology; D010614:Pharynx / Q000382:microbiology; D015995:Prevalence; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000453:epidemiology; D013297:Streptococcus pyogenes / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; D002981:Clindamycin; D004917:Erythromycin; C106791:telithromycin