Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties.
In order to develop therapeutic agents against neurodegenerative diseases, we designed novel antioxidants containing N-t-butyl-N-hydroxylaminophenyl moieties and evaluated in vitro and in vivo neuroprotective properties as well as anti-ischemic effects.
Kim
Kyung Mi
KM
Department of Chemistry, Yonsei University, 120-749, Seoul, South Korea.
Kim
Kyung Hwa
KH
Kang
Tae Cheon
TC
Kim
Won Yeon
WY
Lee
Myung ryul
Mr
Jung
Hyuk Jun
HJ
Hwang
In Koo
IK
Ko
Sung Bo
SB
Koh
Jae Young
JY
Won
Moo Ho
MH
Oh
Eu gene
Eg
Shin
Injae
I
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology; D006898:Hydroxylamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D054833:Isoindoles; D015227:Lipid Peroxidation / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D016566:Organoselenium Compounds / Q000494:pharmacology; D010084:Oxidation-Reduction
D000975:Antioxidants; D001393:Azoles; D016166:Free Radical Scavengers; D006898:Hydroxylamines; D054833:Isoindoles; C481318:N-t-butyl-N-hydroxylaminophenyl; D018696:Neuroprotective Agents; D016566:Organoselenium Compounds; C042986:ebselen