title: Candida dubliniensis infections in a pediatric population: retrospective identification from clinical laboratory isolates of Candida albicans.
abstract: Candida dubliniensis is a recently described species that shares many phenotypic and morphological features with Candida albicans. The clinical significance of isolating C. dubliniensis from the pediatric population is not clear, as most clinical isolates have been recovered from the oral cavities or bloodstreams of adults infected with human immunodeficiency virus. In order to understand further the epidemiology of C. dubliniensis in our pediatric population, we identified C. dubliniensis isolates from clinical isolates previously identified in the laboratory as C. albicans and conducted a retrospective chart review of cases of C. dubliniensis infections. A total of 205 isolates from 183 patients were tested, and only 14 (6.8%) were identified as C. dubliniensis. In 5 of the 14 positive cultures, C. dubliniensis was the sole organism isolated (two respiratory tract specimens, one tongue specimen, one vaginal specimen, and one skin specimen). A case review showed that there were no adverse outcomes for any of the patients, and only one of the patients with cultures positive for C. dubliniensis was immunocompromised. In our pediatric population, the distinction of C. dubliniensis from C. albicans did not prove to have significant clinical relevance. Data from further investigations may help to define better the role of C. dubliniensis as a potential pathogen in children.
authors.affiliation: Department of Pediatrics, Division of Infectious Diseases, University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. jeanokim@yahoo.com
authors.forename: Jean O
authors.initials: JO
authors.lastname: Kim
authors.forename: Lucille
authors.initials: L
authors.lastname: Garofalo
authors.forename: Deborah
authors.initials: D
authors.lastname: Blecker-Shelly
authors.forename: Karin L
authors.initials: KL
authors.lastname: McGowan
mesh_terms: D000293:Adolescent; D000328:Adult; D002175:Candida / Q000145:classification* / Q000302:isolation & purification; D002176:Candida albicans / Q000145:classification*; D002177:Candidiasis / Q000382:microbiology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003470:Culture Media; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies
chemical_list: D003470:Culture Media