The relationship between Lewy body disease, Parkinson's disease, and Alzheimer's disease.
The nosological relationship between Parkinson's disease, dementing syndromes with Lewy bodies, and Alzheimer's disease has been the subject of continuing debate. Here I argue, on the basis of recent data from families with hereditary versions of these diseases and from transgenic modeling, that these nosological debates are inevitable, impossible to resolve, and a product of the fact that we define diseases as entities rather than processes.
Hardy
John
J
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. hardyj@mail.nih.gov
D000544:Alzheimer Disease / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D020961:Lewy Body Disease / Q000503:physiopathology*; D051379:Mice; D010300:Parkinson Disease / Q000503:physiopathology*