title: Intussusception in southern Indian children: lack of association with diarrheal disease and oral polio vaccine immunization.
abstract: BACKGROUND
  Intussusception is the most common cause of intestinal obstruction in young children and has been reported as a complication of a recently withdrawn tetravalent reassortant rotavirus vaccine.
  
  
  METHODS
  We studied the history, clinical presentation, management and outcome of intussusception presenting to a tertiary care hospital in southern India over a 10-year period, in order to assess potential association with diarrheal disease and immunization.
  
  
  RESULTS
  Data from 137 index cases and 280 control subjects indicated that the risk of diarrheal disease or oral polio vaccine administration in the month prior to presentation was similar in the index cases and controls. Mean time to presentation to hospital after developing symptoms was 1.8 days, and 77.3% of patients required surgery, with 47.4% undergoing intestinal resection. Mortality was 0.006%.
  
  
  CONCLUSIONS
  No association could be demonstrated between gastroenteritis or oral poliovirus vaccine immunization and intussusception in southern Indian children. These children presented later and required operative intervention more frequently than has been reported in other studies, but had a good outcome with low mortality.
authors.affiliation: Department of Gastrointestinal Sciences, Christian Medical College Hospital, Vellore 632 004.
authors.forename: T
authors.initials: T
authors.lastname: Raman
authors.forename: A
authors.initials: A
authors.lastname: Mukhopadhyaya
authors.forename: C E
authors.initials: CE
authors.lastname: Eapen
authors.forename: V
authors.initials: V
authors.lastname: Aruldas
authors.forename: A
authors.initials: A
authors.lastname: Bose
authors.forename: S
authors.initials: S
authors.lastname: Sen
authors.forename: M K
authors.initials: MK
authors.lastname: Estes
authors.forename: G
authors.initials: G
authors.lastname: Kang
mesh_terms: D016022:Case-Control Studies; D002669:Child Welfare; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology / Q000628:therapy; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000453:epidemiology / Q000628:therapy; D007080:Ileocecal Valve; D007114:Immunization; D007194:India / Q000453:epidemiology; D007223:Infant; D007229:Infant Welfare; D007443:Intussusception / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D011051:Poliomyelitis / Q000453:epidemiology / Q000628:therapy; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D011055:Poliovirus Vaccine, Oral