Search for new cyclic AMP-binding proteins.
Today, there is evidence that the cAMP-dependent kinases (PKA) are not the only intracellular receptors involved in intracellular cAMP signalling in eukaryotes. Other cAMP-binding proteins have been recently identified, including some cyclic nucleotide-gated channels and Epac (exchange protein directly activated by cAMP) proteins. All these proteins bind cAMP through conserved cyclic nucleotide monophosphate-binding domains. However, all putative cAMP-binding proteins having such domains, as revealed by computer analysis, do not necessarily bind cAMP, indicating that their presence is not a sufficient criteria to predict cAMP-binding property for a protein.
Dremier
S
S
IRIBHM, Faculty of Medicine, Free University of Brussels, 808 Route de Lennik, 1070 Brussels, Belgium. sdremier@ulb.ac.be
Kopperud
R
R
Doskeland
S O
SO
Dumont
J E
JE
Maenhaut
C
C
D000595:Amino Acid Sequence; D000818:Animals; D016384:Consensus Sequence; D000242:Cyclic AMP / Q000378:metabolism*; D002373:Cyclic AMP Receptor Protein / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D002373:Cyclic AMP Receptor Protein; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases