Is the onset of psychoactive drug effects compatible with a protein-synthesis mechanism?
While many have suggested that protein synthesis may mediate the action of antipsychotic drugs, it is difficult to test. In this math modeling study it is found that the time course of action of the drugs are compatible with a protein-synthesis model and, furthermore, that the half-lives required by the model are indeed found in relevant proteins in the brain.
Kuhar
M J
MJ
Yerkes Regional Primate Research Center, Division of Neuroscience, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA. mkuhar@my.emory.edu
Joyce
A R
AR
D000818:Animals; D006801:Humans; D008959:Models, Neurological; D014176:Protein Biosynthesis; D011619:Psychotropic Drugs / Q000494:pharmacology / Q000627:therapeutic use*; D012559:Schizophrenia / Q000378:metabolism
D011619:Psychotropic Drugs