title: Plasma volume expansion by medium molecular weight hydroxyethyl starch in neonates: a pilot study.
abstract: OBJECTIVE
  To study the renal effects (measured by creatininemia) of plasma volume expansion with a medium molecular weight hydroxyethyl starch in the newborn.
  
  
  METHODS
  A prospective, randomized, double-blinded, pilot study.
  
  
  METHODS
  The study included 26 neonates weighing 690-4030 g (gestational age, 26-40 wks), without cardiac or renal failure or major hemostasis abnormalities and requiring a peripherally inserted central catheter for parenteral nutrition.
  
  
  METHODS
  Pediatric and neonatal intensive care unit of a university-affiliated hospital.
  
  
  METHODS
  Plasma volume expansion was performed to facilitate insertion of the central catheter. After parental consent, neonates were randomly allocated to receive intravenous infusions at 10 mL.kg(-1) of 5% albumin or 6% hydroxyethyl starch 200/0.5. Sample size was calculated to detect an increase in mean creatininemia of >20 micromol.L(-1) (with alpha = 0.05, beta = 0.80).
  
  
  RESULTS
  No clinically or statistically significant differences were found between the two groups 6 hrs, 24 hrs, 48 hrs, and 7 days after plasma volume expansion. The study could detect an increase in creatininemia > or =20 micromol.L(-1) with a power of 80%.
  
  
  CONCLUSIONS
  In 13 healthy neonates, plasma volume expansion with 10 mL.kg(-1) of 6% hydroxyethyl starch 200/0.5 does not increase creatininemia.
authors.affiliation: Pediatric and Neonatal Critical Care Unit, University Hospital of Nantes, Nantes, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Liet
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Bellouin
authors.forename: Cécile
authors.initials: C
authors.lastname: Boscher
authors.forename: Corinne
authors.initials: C
authors.lastname: Lejus
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Rozé
mesh_terms: D000367:Age Factors; D000418:Albumins / Q000008:administration & dosage / Q000494:pharmacology; D001802:Blood Substitutes / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage / Q000494:pharmacology*; D007231:Infant, Newborn; D007234:Infant, Premature; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008970:Molecular Weight; D010288:Parenteral Nutrition; D010865:Pilot Projects; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D000418:Albumins; D001802:Blood Substitutes; D006895:Hydroxyethyl Starch Derivatives