[Clinicopathological and immunohistochemical analysis of gastrointestinal, urinary and perineal stromal tumors].
OBJECTIVE
To study the histogenesis and pathological characteristics of gastrointestinal stromal tumors (GIST) and GIST type stromal tumor (ST) beyond the gastrointestinal tract.


METHODS
A retrospective study was carried out on leiomyoma, leiomyosarcoma and neurilemoma (46 cases in gastrointestinal tract and l3 cases in urinary tract and perineal area). 4 antibodies (CD117, CD34, SMA, S-100) were used for immunohistochemical staining.


RESULTS
Among 45 cases of GIST, the positive rate of CD117 and CD34 was 93.3% and 88.9% respectively. Among 12 cases of GIST type ST beyond the gastrointestinal tract, the positive rate of CD117 and CD34 was 83.3% and 75.0% respectively. In 2 cases (1 in gastrointestinal tract) of leiomyomas, both CD117 and CD 34 were negative in tumor cells, while SMA was extensively positive.


CONCLUSIONS
CD117 and CD34 positivity are the most valuable factors in diagnosing ST. Both GIST and GIST type ST beyond the gastrointestinal tract are considered originating from a proto-interstitial stem cell with disoriented differentiation.
Yu
Gong-huang
GH
Department of Pathology, Red Cross Hospital, Hangzhou 310003, China.
Ni
Xing-hao
XH
Qian
Feng
F
Chen
Li-hong
LH
D000199:Actins / Q000032:analysis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007889:Leiomyoma / Q000737:chemistry / Q000473:pathology; D007890:Leiomyosarcoma / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009442:Neurilemmoma / Q000737:chemistry / Q000473:pathology; D010386:Pelvic Neoplasms / Q000737:chemistry / Q000473:pathology; D010502:Perineum; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis*; D012189:Retrospective Studies; D009418:S100 Proteins / Q000032:analysis; D014571:Urologic Neoplasms / Q000737:chemistry / Q000473:pathology*
D000199:Actins; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D009418:S100 Proteins; D019009:Proto-Oncogene Proteins c-kit