title: Ovarian stromal hyperplasia and ovarian vein steroid levels in relation to endometrioid endometrial cancer.
abstract: OBJECTIVE
  To study the relationship between the presence of endometrioid endometrial cancer, the degree of ovarian stromal hyperplasia and ovarian steroid production in postmenopausal women.
  
  
  METHODS
  Retrospective and prospective study, respectively.
  
  
  METHODS
  Medical Centre Leeuwarden and the University Hospital Groningen, The Netherlands. Postmenopausal women with or without endometrial cancer, undergoing a hysterectomy with bilateral salpingo-oophorectomy.
  
  
  METHODS
  In 112 women with endometrioid endometrial cancer, 47 women with a benign gynaecological condition and 10 women with non-endometrioid endometrial cancer, the degree of ovarian stromal hyperplasia was scored retrospectively on a semi-quantitative scale (atrophy, slight, marked). All women were postmenopausal and had undergone a hysterectomy with bilateral salpingo-oophorectomy. Prospectively, blood sampling from the ovarian veins was performed in a further 60 women. Steroid levels (oestrone, oestradiol, androstenedione, testosterone) were determined and related to the degree of ovarian stromal hyperplasia and the presence (n = 52) or absence (n = 8) of endometrioid endometrial cancer.
  
  
  METHODS
  Degree of ovarian stromal hyperplasia and steroid levels in the utero-ovarian circulation.
  
  
  RESULTS
  In the retrospective study, the degree of ovarian stromal hyperplasia was higher in the presence of endometrioid endometrial cancer (P = 0.0001). The prospective study showed that an increasing degree of ovarian stromal hyperplasia was related to higher ovarian levels of both testosterone and androstenedione (P < 0.05 and P < 0.005, respectively), but not to oestrone or oestradiol. A non-significant increase in mean ovarian vein levels of both testosterone and androstenedione was seen in patients with endometrial cancer as compared with patients with benign conditions.
  
  
  CONCLUSIONS
  In endometrioid endometrial cancer, higher degrees of ovarian stromal hyperplasia were found and with increasing degrees of ovarian stromal hyperplasia, levels of ovarian vein androgens were higher. A causal relationship in the origin of hormone-dependent endometrial pathology may exist between ovarian stromal hyperplasia, ovarian vein androgen levels and endometrioid endometrial carcinoma.
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital Groningen, The Netherlands.
authors.forename: V H W M
authors.initials: VH
authors.lastname: Jongen
authors.forename: H
authors.initials: H
authors.lastname: Hollema
authors.forename: A G J
authors.initials: AG
authors.lastname: van der Zee
authors.forename: J G
authors.initials: JG
authors.lastname: Santema
authors.forename: M J
authors.initials: MJ
authors.lastname: Heineman
mesh_terms: D000735:Androstenedione / Q000097:blood; D018269:Carcinoma, Endometrioid / Q000097:blood / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000097:blood / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000097:blood; D008875:Middle Aged; D010053:Ovary / Q000098:blood supply / Q000473:pathology*; D017698:Postmenopause / Q000097:blood; D011446:Prospective Studies; D012189:Retrospective Studies; D013256:Steroids / Q000097:blood*; D013739:Testosterone / Q000097:blood; D014680:Veins
chemical_list: D013256:Steroids; D013739:Testosterone; D000735:Androstenedione