title: Bone marrow precursor of extranodal T-cell lymphoma.
abstract: The development of extranodal lymphomas is thought to be initiated by the transformation event in peripheral organs. Lymphomatoid papulosis (LyP) is a low-grade cutaneous lymphoma and may progress into the cutaneous anaplastic lymphoma. We identified 2 patients who 3 and 4 years before the development of LyP were treated for an unrelated malignancy (Burkitt lymphoma and small-cell B-cell lymphoma). We analyzed the T-cell receptor (TCR) gene rearrangement pattern in their skin, blood, and bone marrow, including the archival bone marrow sampled years before the development of clinically evident LyP. In all samples we detected the unique monoclonal TCR rearrangements. This observation suggests that the initial malignant transformation in LyP occurred in bone marrow and not, as could be supposed, in the skin.
authors.affiliation: Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, Bldg D42, Bispebjerg bakke 23, DK-2400 Copenhagen, Denmark. rg01@bbh.hosp.dk
authors.forename: Robert
authors.initials: R
authors.lastname: Gniadecki
authors.forename: Ansgar
authors.initials: A
authors.lastname: Lukowsky
authors.forename: Kristian
authors.initials: K
authors.lastname: Rossen
authors.forename: Hans O
authors.initials: HO
authors.lastname: Madsen
authors.forename: Kristian
authors.initials: K
authors.lastname: Thomsen
authors.forename: Hans Christian
authors.initials: HC
authors.lastname: Wulf
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells; D005260:Female; D015321:Gene Rearrangement; D019672:Genes, T-Cell Receptor; D006801:Humans; D017730:Ki-1 Antigen; D017728:Lymphoma, Large-Cell, Anaplastic / Q000209:etiology / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000209:etiology / Q000473:pathology*; D017731:Lymphomatoid Papulosis / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000473:pathology
chemical_list: D017730:Ki-1 Antigen