title: The effect of 5-year vitamin C supplementation on serum pepsinogen level and Helicobacter pylori infection.
abstract: We conducted a population-based, double-blind, randomized controlled trial to examine the effect of vitamin C supplementation on serum pepsinogen (PG) level, Helicobacter pylori (H. pylori ) infection, and cytotoxin-associated gene A (Cag A) status. Subjects aged 40 to 69 years living in one village in Akita prefecture, a high-risk area for gastric cancer in Japan, were recruited through annual health check-up programs. Among 635 subjects diagnosed as having chronic gastritis on the basis of serum PG levels, after excluding ineligible cases, 439 subjects were assigned to one of four groups using a 2 x 2 factorial design (0 or 15 mg/day beta-carotene and 50 or 500 mg/day vitamin C). However, based on the results from two beta-carotene trials in the United States, we discontinued beta-carotene (vitamin C supplementation was continued). Finally, 120 subjects in the low-dose group (vitamin C 50 mg), and 124 subjects in the high-dose group (vitamin C 500 mg) completed the 5-year supplementation. The difference in the change of PGI/II ratio between baseline and after 5-year follow up was statistically significant between the intervention groups among those who completed the supplementation: - 0.25 for the low-dose group and - 0.13 for the high-dose group (P = 0.046). To conclude, vitamin C supplementation may protect against progression of gastric mucosal atrophy.
authors.affiliation: Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Kashiwa 277-8577, Japan.
authors.forename: Shizuka
authors.initials: S
authors.lastname: Sasazuki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sasaki
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Tsubono
authors.forename: Shunji
authors.initials: S
authors.lastname: Okubo
authors.forename: Masato
authors.initials: M
authors.lastname: Hayashi
authors.forename: Tadao
authors.initials: T
authors.lastname: Kakizoe
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial / Q000097:blood; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000097:blood; D001426:Bacterial Proteins / Q000097:blood; D002908:Chronic Disease; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005757:Gastritis, Atrophic / Q000097:blood* / Q000382:microbiology; D016481:Helicobacter Infections / Q000097:blood* / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood*; D020115:Pepsinogen C / Q000097:blood*; D013997:Time Factors
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori; D020115:Pepsinogen C; D020116:Pepsinogen A; D001205:Ascorbic Acid