title: Human and mouse proteases: a comparative genomic approach.
abstract: The availability of the human and mouse genome sequences has allowed the identification and comparison of their respective degradomes--the complete repertoire of proteases that are produced by these organisms. Because of the essential roles of proteolytic enzymes in the control of cell behaviour, survival and death, degradome analysis provides a useful framework for the global exploration of these protease-mediated functions in normal and pathological conditions.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain.
authors.forename: Xose S
authors.initials: XS
authors.lastname: Puente
authors.forename: Luis M
authors.initials: LM
authors.lastname: Sánchez
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Overall
authors.forename: Carlos
authors.initials: C
authors.lastname: López-Otín
mesh_terms: D000818:Animals; D019295:Computational Biology; D016208:Databases, Factual; D010450:Endopeptidases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D016678:Genome; D006801:Humans; D008957:Models, Genetic
chemical_list: D010450:Endopeptidases