[Association of HLA-DPB1 alleles with chronic myelogenous leukemia in southern Chinese Hans].
To clarify the association between HLA-DPB1 alleles and chronic myelogenous leukemia (CML) in South Chinese, the allelic types of HLA-DPB1 were detected by sequence based typing (SBT) in 86 patients with CML and 82 healthy individuals from Southern China. The results showed that the frequencies of HLA-DPB1 * 1301 and DPB1 * 20011 were higher in patients with CML in comparison with those of healthy individuals. It is concluded that positive association may exist between certain HLA-DPB1 alleles and CML.
Tian
Hong
H
Department of Hematology, Nanfang Hospital, The First Military Medical University, Guangzhou, 510515, China.
Zhou
Shu-Yun
SY
Liu
Ze-Huan
ZH
Fu
Yong-Gui
YG
Lu
Feng-Juan
FJ
Lin
Jiang-Hai
JH
Xu
An-Long
AL
D000483:Alleles; D016009:Chi-Square Distribution; D002681:China; D005787:Gene Frequency; D005838:Genotype; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen