title: Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients.
abstract: Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios. Ann Neurol 2003;54:119-122
authors.affiliation: Laboratoire Universitaire d'Immunologie (UPRES EA 1257, IFR 97) and Etablissement Français du Sang Bretagne, Faculté de Médecine, Rennes, France.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Alizadeh
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Babron
authors.forename: Brigitte
authors.initials: B
authors.lastname: Birebent
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Matsuda
authors.forename: Erwann
authors.initials: E
authors.lastname: Quelvennec
authors.forename: Roland
authors.initials: R
authors.lastname: Liblau
authors.forename: Isabelle
authors.initials: I
authors.lastname: Cournu-Rebeix
authors.forename: Patricia
authors.initials: P
authors.lastname: Momigliano-Richiardi
authors.forename: Jorge
authors.initials: J
authors.lastname: Sequeiros
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Yaouanq
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Genin
authors.forename: Alexandre
authors.initials: A
authors.lastname: Vasilescu
authors.forename: Héloise
authors.initials: H
authors.lastname: Bougerie
authors.forename: Maria
authors.initials: M
authors.lastname: Trojano
authors.forename: Berta
authors.initials: B
authors.lastname: Martins Silva
authors.forename: Patricia
authors.initials: P
authors.lastname: Maciel
authors.forename: Françoise
authors.initials: F
authors.lastname: Clerget-Darpoux
authors.forename: Michel
authors.initials: M
authors.lastname: Clanet
authors.forename: Gilles
authors.initials: G
authors.lastname: Edan
authors.forename: Bertrand
authors.initials: B
authors.lastname: Fontaine
authors.forename: Gilbert
authors.initials: G
authors.lastname: Semana
mesh_terms: D000069594:Abatacept; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics*; D060908:CTLA-4 Antigen; D015331:Cohort Studies; D017931:DNA Primers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D006801:Humans; D015151:Immunoblotting; D018796:Immunoconjugates; D009103:Multiple Sclerosis / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D017931:DNA Primers; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C106559:HLA-DR15 antigen; D018796:Immunoconjugates; D000069594:Abatacept