Acute Philadelphia chromosome-positive leukemia in an adolescent boy after liver transplantation.
Acute leukemia is an untoward event following immunosuppression for solid organ transplantation and is related to the oncogenic effects of Epstein-Barr viral infections. The authors report a case of acute, Philadelphia chromosome-positive, T-cell lymphoblastic leukemia following liver transplantation. Molecular typing demonstrated a minor bcr-abl rearrangement (190 kD), which persisted in remission in 71% of peripheral neutrophils as determined by fluorescence in situ hybridization. The authors conclude that this patient may have presented in a lymphoid blast crisis of chronic myelogenous leukemia with an acute T-cell leukemia/lymphoma syndrome.
Silliman
Christopher C
CC
Bonfils Blood Center, 717 Yosemite Circle, Denver, CO 80220, U.S.A. christopher.silliman@uchsc.edu
Tyson
R Weslie
RW
Wei
Qi
Q
Karrer
Frederick G
FG
Davies
Stella M
SM
Blake
Marilyn
M
McGavran
Loris
L
D000293:Adolescent; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D017404:In Situ Hybridization, Fluorescence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D016031:Liver Transplantation / Q000009:adverse effects / Q000276:immunology; D008297:Male; D011183:Postoperative Complications
D016044:Fusion Proteins, bcr-abl