Chlamydia pneumoniae in children with MS: frequency and quantity of intrathecal antibodies.
The authors investigated the frequency and quantity of intrathecal antibody synthesis against Chlamydia pneumoniae and the presence of C pneumoniae antigen in 25 children with MS. C pneumoniae genome was present in two children. In seven children an intrathecal synthesis of C pneumoniae antibodies was detected, representing only a small part of the total intrathecal immunoglobulin G, suggesting that this intrathecal synthesis is part of a polyspecific, oligoclonal immune response.
Rostasy
K
K
Department of Pediatric Neurology, University of Göttingen, Germany. Krostasy@excite.com
Reiber
H
H
Pohl
D
D
Lange
P
P
Ohlenbusch
A
A
Eiffert
H
H
Maass
M
M
Hanefeld
F
F
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid*; D000918:Antibody Specificity; D002555:Cerebrospinal Fluid / Q000276:immunology / Q000382:microbiology; D002648:Child; D023521:Chlamydophila Infections / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D016993:Chlamydophila pneumoniae / Q000276:immunology* / Q000302:isolation & purification; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D043025:Oligoclonal Bands