Investigation of the early stages in soraphen A biosynthesis.
The unusual benzoate starter unit in soraphen A derives from phenylalanine via cinnamate in a beta-oxidative (plant-like) pathway; 3-phenyl-3-hydroxypropanoate incorporates directly into soraphen by loading onto module 2 of the PKS and indirectly from the beta-oxidative pathway to generate benzoyl CoA.
Hill
Alison M
AM
Department of Chemistry, King's College London, Strand, London, UK WC2R 2LS. a.m.hill@ex.ac.uk
Thompson
Betty L
BL
Harris
Jonathan P
JP
Segret
Roger
R
D000935:Antifungal Agents / Q000096:biosynthesis; D001565:Benzoates / Q000737:chemistry; D002934:Cinnamates / Q000737:chemistry; D003066:Coenzyme A Ligases / Q000096:biosynthesis; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D009097:Multienzyme Complexes / Q000378:metabolism; D009231:Myxococcales / Q000254:growth & development / Q000378:metabolism*; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000378:metabolism*; D010666:Phenylpropionates / Q000737:chemistry / Q000378:metabolism
D000935:Antifungal Agents; D001565:Benzoates; D002934:Cinnamates; D018942:Macrolides; D009097:Multienzyme Complexes; D010666:Phenylpropionates; C086151:soraphen A; C031579:beta-hydroxyphenylpropionic acid; D010649:Phenylalanine; D003066:Coenzyme A Ligases; C055455:benzoate coenzyme A ligase