title: Anesthetic risks for donors in living-related liver transplantation: analysis of 30 cases.
abstract: Liver transplantation involving living-related donors has been adopted in many centers as a way of relieving organ shortage. This study reviewed the anesthetic considerations for donor operations at our institution in relation to intraoperative blood transfusion, complications, and postoperative liver function test results. From January 1990 to May 2001, 30 living-related liver transplantations were performed at Başkent University Hospital, Ankara. The donor data used for analysis were retrospectively obtained through chart review, anesthesia records, and the computerized hospital database. Left lobectomy was performed in 19 cases, and left lateral segmentectomy in 11 cases. Intraoperatively, the average volume of intravenous fluids used was 6431+/-468 ml, and the average amount of blood transfused was 2.1+/-0.4 units. The mean postoperative hospital stay was 11.5+/-1.3 days. The only intraoperative complication observed in these 30 donors was severe bleeding during retrohepatic vena cava dissection in one of the cases. The postoperative complications related to anesthesia were one case each of shoulder pain, neuropraxia, and compartment syndrome. The levels of total and direct bilirubin, aspartate aminotransferase, and alanine aminotransferase peaked within the first 2 postoperative days (2.19+/-0.36 mg/dl, 1.02+/-0.18 mg/dl, 245.7+/-26.6 U/l, 313.5+/-51.9 U/l, respectively). In all 30 donors, these levels had normalized by 1 month after surgery. Maximal efforts must be applied in the anesthetic approach to minimize donor complications in living-related liver transplantation; however, this will not completely eliminate some risks to the donor.
authors.affiliation: Department of Anesthesiology, Başkent University School of Medicine, Ankara, Turkey. elifakpek@baskent-ank.edu.tr
authors.forename: Elif A
authors.initials: EA
authors.lastname: Akpek
authors.forename: Gülnaz
authors.initials: G
authors.lastname: Arslan
authors.forename: Ciğdem
authors.initials: C
authors.lastname: Erkaya
authors.forename: Adnan
authors.initials: A
authors.lastname: Torgay
authors.forename: Asli
authors.initials: A
authors.lastname: Dönmez
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Kayhan
authors.forename: Hamdi
authors.initials: H
authors.lastname: Karakayali
mesh_terms: D000328:Adult; D000758:Anesthesia / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000706:statistics & numerical data*; D019520:Living Donors / Q000706:statistics & numerical data*; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors