title: Basal pulmonary vascular resistance and nitric oxide responsiveness late after Fontan-type operation.
abstract: BACKGROUND
  The pulsatile nature of pulmonary blood flow is important for shear stress-mediated release of endothelium-derived nitric oxide (NO) and lowering pulmonary vascular resistance (PVR) by passive recruitment of capillaries. Normal pulsatile flow is lost or markedly attenuated after Fontan-type operations, but to date, there are no data on basal pulmonary vascular resistance and its responsiveness to exogenous NO at late follow-up in these patients.
  
  
  RESULTS
  We measured indexed PVR (PVRI) using Fick principle to calculate pulmonary blood flow, with respiratory mass spectrometry to measure oxygen consumption, in 15 patients (median age, 12 years; range, 7 to 17 years; 12 male, 3 female) at a median of 9 years after a Fontan-type operation (6 atriopulmonary connections, 7 lateral tunnels, 2 extracardiac conduits). The basal PVRI was 2.11+/-0.79 Wood unit (WU) times m2 (mean+/-SD) and showed a significant reduction to 1.61+/-0.48 (P=0.016) after 20 ppm of NO for 10 minutes. The patients with nonpulsatile group in the pulmonary circulation dropped the PVRI from 2.18+/-0.34 to 1.82+/-0.55 (P<0.05) after NO inhalation.
  
  
  CONCLUSIONS
  PVR falls with exogenous NO late after Fontan-type operation. These data suggest pulmonary endothelial dysfunction, related in some part to lack of pulsatility in the pulmonary circulation because of altered flow characteristics. Therapeutic strategies to enhance pulmonary endothelial NO release may have a role in these patients.
authors.affiliation: Cardiothoracic Unit, Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, UK. s.khambadkone@ich.ucl.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Khambadkone
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: M R
authors.initials: MR
authors.lastname: de Leval
authors.forename: S
authors.initials: S
authors.lastname: Cullen
authors.forename: J E
authors.initials: JE
authors.lastname: Deanfield
authors.forename: A N
authors.initials: AN
authors.lastname: Redington
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000367:Age Factors; D000792:Angiography; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D006328:Cardiac Catheterization; D002648:Child; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D005260:Female; D018729:Fontan Procedure; D006330:Heart Defects, Congenital / Q000601:surgery; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage*; D010101:Oxygen Consumption / Q000502:physiology; D011652:Pulmonary Circulation / Q000187:drug effects / Q000502:physiology*; D011673:Pulsatile Flow / Q000502:physiology; D013995:Time; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology*
chemical_list: D009569:Nitric Oxide