From fragile X mental retardation protein to Rac1 GTPase: new insights from Fly CYFIP.
Mutations in either the Rho GTPase pathway or in the fragile X mental retardation (FMR1) gene produce neuronal connectivity defects. In this issue of Neuron, Schenck et al. use biochemical and genetic approaches in Drosophila to examine the interactions between dFMR1 and dRac1 and provide evidence that the cytoplasmic FMRP interacting protein (CYFIP) links Rac-dependent cytoskeleton remodeling and dFMR1-dependent control of translation in a unique pathway to modulate neuronal morphogenesis.
Billuart
Pierre
P
Institut Cochin, INSERM unité 567, CNRS 8104, Université Paris V, CHU Cochin, 24 Rue du Faubourg Saint Jacques, 75014, Paris, France.
Chelly
Jamel
J
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics; D051860:Fragile X Messenger Ribonucleoprotein 1; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics; D009474:Neurons / Q000648:ultrastructure*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D020744:rac GTP-Binding Proteins / Q000235:genetics / Q000502:physiology; D020830:rac1 GTP-Binding Protein
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D029721:Drosophila Proteins; D051860:Fragile X Messenger Ribonucleoprotein 1; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; D020744:rac GTP-Binding Proteins; D020830:rac1 GTP-Binding Protein; C109916:CYFIP1 protein, human; C467328:FMR1 protein, Drosophila; C497683:FMR1 protein, human; C090146:Rac1 protein, Drosophila; C484666:Sra-1 protein, Drosophila