title: Protein interactions provide new insight into Nm23/nucleoside diphosphate kinase functions.
abstract: Nm23-NDPKs besides contributing to the maintenance of the cellular nucleoside triphosphate pool, exert regulatory properties in a variety of cellular events including proliferation, invasiveness, development, differentiation, and gene regulation. This review focuses on recently discovered protein-protein interactions involving the Nm23 proteins. The findings herein summarized provide new and intriguing suggestions for a more extensive understanding of the biological functions of the Nm23 proteins.
authors.affiliation: Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy. lombardi@ifo.it
authors.forename: D
authors.initials: D
authors.lastname: Lombardi
authors.forename: A M
authors.initials: AM
authors.lastname: Mileo
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D000956:Antigens, Viral / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D002352:Carrier Proteins / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division; D019309:Epstein-Barr Virus Nuclear Antigens; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism*; D009701:Nucleoside-Diphosphate Kinase / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases; D011485:Protein Binding; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D016615:Telomere / Q000737:chemistry / Q000378:metabolism*; D015533:Transcriptional Activation / Q000502:physiology*; D020798:Two-Hybrid System Techniques
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000956:Antigens, Viral; D002352:Carrier Proteins; C498774:EBNA-3C, epstein-barr virus; D019309:Epstein-Barr Virus Nuclear Antigens; C108257:ITGB1BP1 protein, human; D047908:Intracellular Signaling Peptides and Proteins; C105373:MEN1 protein, human; D008565:Membrane Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D009701:Nucleoside-Diphosphate Kinase; C438732:PRUNE1 protein, human; D010744:Phosphoric Monoester Hydrolases