Olfactory mucosa histological findings in laryngectomees.
After total laryngectomy, the patients often report immediate and marked olfactory deficit. The aim of this study was to determine whether hyposmia in laryngectomees reflects olfactory epithelial damage. Ten laryngectomized patients and ten rhinologically normal subjects were subjected to olfactory testing, after which histological examination of biopsied olfactory mucosa was performed. Olfactory testing in laryngectomees revealed a marked reduction in odor perception. Histological examination of olfactory mucosa specimens showed that in laryngectomees some neuroepithelial structural features were comparable with those found in normal subjects. However, additional signs of damage were also observed, consisting mainly of various degrees of epithelial degeneration, above and beyond those that are characteristic of physiological epithelium turnover. These different degenerative features consisted of severe damage to the neuroepithelium, culminating in complete topical loss. Bowman's glands were also observed to be involved in the degenerative process. Laryngectomy-induced hyposmia seems to be correlated with the almost complete loss of nasal airflow due to the disconnection between the upper and lower airways, which prevents odor molecules from reaching the olfactory area, together with degenerative phenomena, which affect the neuroepithelium, and consequent failure in neurosensorial performance.
Miani
Cesare
C
Department of Surgical Sciences, Otolaryngology Section, University of Udine, Piazzale S. M. della Misericordia, 33100 Udine, Italy. cmiani@uniud.it
Ortolani
Fulvia
F
Bracale
Anna Maria Bergamin
AM
Petrelli
Lucia
L
Staffieri
Alberto
A
Marchini
Maurizio
M
D000368:Aged; D001706:Biopsy; D005260:Female; D006801:Humans; D007825:Laryngectomy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000209:etiology* / Q000473:pathology; D009831:Olfactory Mucosa / Q000473:pathology*