Relaxant effect of essential oil of Melissa officinalis and citral on rat ileum contractions.
The relaxant effect of the essential oil of Melissa officinalis and its main component, citral, on rat isolated ileum contractions was evaluated. M. officinalis essential oil (MOEO) inhibited the response to KCl (80 mM), ACh (320 nM) and 5-HT (1.28 microM) in a concentration-dependent manner with a IC(50) of approximately 20 ng/ml. Citral also had a concentration-dependent inhibitory effect on contraction of rat ileum with IC(50)s comparable to that of MOEO.
Sadraei
H
H
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. hsadraei@yahoo.com
Ghannadi
A
A
Malekshahi
K
K
D000080462:Acyclic Monoterpenes; D000818:Animals; D003109:Colonic Diseases, Functional / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D008401:Gas Chromatography-Mass Spectrometry; D007082:Ileum / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D008297:Male; D031334:Melissa; D039821:Monoterpenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D009119:Muscle Contraction / Q000187:drug effects; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D000080462:Acyclic Monoterpenes; D039821:Monoterpenes; D010276:Parasympatholytics; D010938:Plant Oils; C007076:citral