title: Antiplaque and antigingivitis effectiveness of a hexetidine mouthwash.
abstract: OBJECTIVE
  To assess the antiplaque/antigingivitis efficacy of a hexetidine-containing mouthwash.
  
  
  METHODS
  This examiner-blind, parallel group, controlled clinical study examined the effectiveness of a hexetidine (0.1%) mouthwash both in inhibiting the development of supragingival plaque and in reducing gingivitis. One hundred and thirty-four adult subjects completed the 2-week experimental gingivitis model study. Following baseline examinations, which included plaque index, modified gingival index and gingival bleeding index, subjects received a full dental prophylaxis. Subjects were randomly assigned to one of three mouthwashes (hexetidine 0.1%, chlorhexidine 0.12% (positive control) or a 5% hydroalcohol negative control) and commenced three times daily supervised rinsing as their sole method of oral hygiene. All indices were rescored after 2 weeks.
  
  
  RESULTS
  Compared to the negative control group, the hexetidine group demonstrated a statistically significant inhibition and reduction of supragingival plaque and gingival inflammation with reductions of 6.3%, 33.5% and 56% for gingivitis, plaque and gingival bleeding, respectively. The results of the chlorhexidine group were used to validate the study.
  
  
  CONCLUSIONS
  The study confirms the efficacy of a hexetidine rinse in reducing supragingival plaque and gingival inflammation.
authors.affiliation: BioSci Research Canada Ltd., Kitimat Road, Mississauga, Ontario, Canada Pfizer Inc, Morris Plains, NJ, USA.
authors.forename: N C
authors.initials: NC
authors.lastname: Sharma
authors.forename: H J
authors.initials: HJ
authors.lastname: Galustians
authors.forename: J
authors.initials: J
authors.lastname: Qaqish
authors.forename: C H
authors.initials: CH
authors.lastname: Charles
authors.forename: J W
authors.initials: JW
authors.lastname: Vincent
authors.forename: J A
authors.initials: JA
authors.lastname: McGuire
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000627:therapeutic use; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D005260:Female; D005891:Gingivitis / Q000517:prevention & control*; D006590:Hexetidine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000627:therapeutic use*; D010512:Periodontal Index; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D006590:Hexetidine; D002710:Chlorhexidine