Modifications of arginines and their role in autoimmunity.
Posttranslational modifications of proteins often perform a key role in the biological functioning of proteins. Some of these modifications also change the immunogenicity of proteins and peptides and create 'self'-antigens which might induce autoimmune responses. In particular modifications of arginines within a defined protein context can lead to a specific B-cell immune response. This review discusses the generation of such modifications and their relevance for autoimmunity.
van Boekel
M A M
MA
Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands. m.vanboekel@ncmls.kun.nl
van Venrooij
W J
WJ
D000818:Animals; D001120:Arginine / Q000378:metabolism*; D015551:Autoimmunity / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D010455:Peptides / Q000276:immunology / Q000378:metabolism; D011499:Protein Processing, Post-Translational / Q000276:immunology*
D010455:Peptides; D001120:Arginine