Activity of telithromycin against penicillin-resistant Streptococcus pneumoniae isolates recovered from French children with invasive and noninvasive infections.
We compared the activities of telithromycin, erythromycin, azithromycin, josamycin, penicillin G, amoxicillin, cefpodoxime, and ceftriaxone against invasive and noninvasive non-penicillin-susceptible Streptococcus pneumoniae isolates recovered from children. Of the 186 isolates tested, 89% were positive for erm(B) by PCR. Telithromycin had the lowest MICs, with MICs at which 90% of the isolates tested are inhibited of 0.032 and 0.25 micro g/ml for erythromycin-sensitive and -resistant isolates, respectively.
Bingen
Edouard
E
Service de Microbiologie, Hôpital Robert Debré, Paris, France. edouard.bingen@rdb.ap-hop-paris.fr
Doit
Catherine
C
Loukil
Chawki
C
Brahimi
Naima
N
Bidet
Philippe
P
Deforche
Dominique
D
Geslin
Pierre
P
D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology; D002648:Child; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D005602:France; D006801:Humans; D066298:In Vitro Techniques; D015570:Josamycin / Q000494:pharmacology; D048628:Ketolides; D018942:Macrolides; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D011008:Pneumococcal Infections / Q000188:drug therapy*; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D000097623:Cefpodoxime
D000658:Amoxicillin; D000900:Anti-Bacterial Agents; D017963:Azithromycin; D015296:Ceftizoxime; D002443:Ceftriaxone; D004917:Erythromycin; D015570:Josamycin; D048628:Ketolides; D018942:Macrolides; D010400:Penicillin G; D010406:Penicillins; D000097623:Cefpodoxime; C106791:telithromycin