title: Trinuclear Cu(II) complex for internucleoside linkage-specific cleavage of RNA.
abstract: Trinuclear Cu(II) complex of N,N,N',N',N",N"-hexa[(2-pyridyl)methyl]-1,3,5-tris(aminomethyl)benzene (L3A) exhibits remarkable substrate-specificity for hydrolysis of 2'-->5' and 3'-->5' ribonucleotides. Up(2'-->5')U is hydrolyzed much efficiently than is Up(3'-->5')U, but Ap(3'-->5')A is overwhelmingly preferable to Ap(2'-->5')A.
authors.affiliation: Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguroku, Tokyo 153-8904, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsumura
authors.forename: S
authors.initials: S
authors.lastname: Kina
authors.forename: J
authors.initials: J
authors.lastname: Sumaoka
authors.forename: S
authors.initials: S
authors.lastname: Tobey
authors.forename: E V
authors.initials: EV
authors.lastname: Anslyn
authors.forename: M
authors.initials: M
authors.lastname: Komiyama
mesh_terms: D003300:Copper / Q000737:chemistry*; D007700:Kinetics; D046911:Macromolecular Substances; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism*; D011725:Pyridines / Q000737:chemistry* / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D012260:Ribonucleases / Q000737:chemistry* / Q000378:metabolism*; D012263:Ribonucleosides / Q000378:metabolism; D012265:Ribonucleotides / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: C476354:(N,N,N',N',N'',N''-hexa((2-pyridyl)methyl)-1,3,5-tris(aminomethyl)benzene)copper(II); D046911:Macromolecular Substances; D009942:Organometallic Compounds; D011725:Pyridines; D012263:Ribonucleosides; D012265:Ribonucleotides; D012313:RNA; D003300:Copper; D012260:Ribonucleases