Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P.
We have determined that the human SEPW1 (selenoprotein W) gene maps to chromosome 19q13.3, spans approximately 6.3 kb and comprises six exons, in contrast to the previously published five exons. The gene lacks canonical TATA and CAAT boxes, but has numerous Sp1 consensus binding sites upstream of multiple transcription start sites. SEPW1 is expressed in all of the 22 tissues assayed, and shows highest expression in skeletal muscle and heart. Additionally, we have also identified a retroprocessed SEPW1 pseudogene, SEPW1P, which maps to chromosome 1p34-35.
Bellingham
James
J
Section of Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK. j.bellingham@imperial.ac.uk
Gregory-Evans
Kevin
K
Fox
Margaret F
MF
Gregory-Evans
Cheryl Y
CY
D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D005091:Exons; D015870:Gene Expression; D006801:Humans; D008969:Molecular Sequence Data; D018482:Muscle, Skeletal / Q000502:physiology; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D011401:Promoter Regions, Genetic; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D011544:Pseudogenes; D051151:Selenoprotein W; D051140:Selenoproteins; D012689:Sequence Homology, Nucleic Acid; D016329:Sp1 Transcription Factor / Q000378:metabolism; D016385:TATA Box; D024363:Transcription Initiation Site
D011506:Proteins; C495240:SELENOW protein, human; D051151:Selenoprotein W; D051140:Selenoproteins; D016329:Sp1 Transcription Factor