title: Complications associated with sentinel lymph node biopsy for melanoma.
abstract: BACKGROUND
  Sentinel lymph node (SLN) biopsy has become widely accepted as a method of staging the regional lymph nodes for patients with melanoma. Although it is often stated that SLN biopsy is a minimally invasive procedure associated with few complications, a paucity of data exists to specifically determine the morbidity associated with this procedure. This analysis was performed to evaluate the morbidity associated with SLN biopsy compared with completion lymph node dissection (CLND).
  
  
  METHODS
  Patients were enrolled in the Sunbelt Melanoma Trial, a prospective multi-institutional study of SLN biopsy for melanoma. Patients underwent SLN biopsy and were prospectively followed up for the development of complications associated with this technique. Patients who had evidence of nodal metastasis in the SLN underwent CLND. Complications associated with SLN biopsy alone were compared with those associated with SLN biopsy plus CLND.
  
  
  RESULTS
  A total of 2120 patients were evaluated, with a median follow-up of 16 months. Overall, 96 (4.6%) of 2120 patients developed major or minor complications associated with SLN biopsy, whereas 103 (23.2%) of 444 patients experienced complications associated with SLN biopsy plus CLND. There were no deaths associated with either procedure.
  
  
  CONCLUSIONS
  SLN biopsy alone is associated with significantly less morbidity compared with SLN biopsy plus CLND.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Louisville, James Graham Brown Cancer Center, Kentucky, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Wrightson
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Wong
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Edwards
authors.forename: Celia
authors.initials: C
authors.lastname: Chao
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Reintgen
authors.forename: Merrick I
authors.initials: MI
authors.lastname: Ross
authors.forename: R Dirk
authors.initials: RD
authors.lastname: Noyes
authors.forename: Vicki
authors.initials: V
authors.lastname: Viar
authors.forename: Patricia B
authors.initials: PB
authors.lastname: Cerrito
authors.forename: Kelly M
authors.initials: KM
authors.lastname: McMasters
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008197:Lymph Node Excision / Q000009:adverse effects*; D008297:Male; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged; D009017:Morbidity; D011183:Postoperative Complications; D021701:Sentinel Lymph Node Biopsy / Q000009:adverse effects*; D012878:Skin Neoplasms / Q000473:pathology*