A principal components analysis of the Autism Diagnostic Interview-Revised.
OBJECTIVE
To develop factors based on the Autism Diagnostic Interview-Revised (ADI-R) that index separate components of the autism phenotype that are genetically relevant and validated against standard measures of the constructs.


METHODS
ADIs and ADI-Rs of 292 individuals with autism were subjected to a principal components analysis using VARCLUS. The resulting variable clusters were validated against standard measures.


RESULTS
Six clusters of variables emerged: spoken language, social intent, compulsions, developmental milestones, savant skills and sensory aversions. Five of the factors were significantly correlated with the validating measures and had good internal consistency, face validity, and discriminant and construct validity. Most intraclass correlations between siblings were adequate for use in genetic studies.


CONCLUSIONS
The ADI-R contains correlated clusters of variables that are valid, genetically relevant, and that can be used in a variety of studies.
Tadevosyan-Leyfer
Ovsanna
O
Department of Psychiatry, Tufts New England Medical Center, Boston, MA, USA.
Dowd
Michael
M
Mankoski
Raymond
R
Winklosky
Brian
B
Putnam
Sara
S
McGrath
Lauren
L
Tager-Flusberg
Helen
H
Folstein
Susan E
SE
D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000175:diagnosis* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D010641:Phenotype; D015203:Reproducibility of Results