Inhaled nitric oxide (iNO) delivery with high-frequency jet ventilation (HFJV).
OBJECTIVE
To determine if nitric oxide (NO) therapy can be reliably administered during high-frequency jet ventilation (HFJV) using the INOvent delivery system.


METHODS
NO concentrations were measured just proximal to the endotracheal (ET) tube and at the distal tip of the ET tube during a bench evaluation. Measurements were taken over a wide range of airway pressure settings and NO concentrations with both high- and low- resistance lung models. Percent changes in set versus proximal and proximal versus distal iNO concentrations were tabulated.


RESULTS
Differences between proximal and distal NO concentrations were 10% or less. In the therapeutic range of up to 20 p.p.m., differences in concentration were 1 p.p.m. or less. There was no consistent effect on NO concentration when airway resistance was increased by 500%.


CONCLUSIONS
Nitric oxide therapy can be reliably administered during HFJV with the INOvent delivery system when NO is injected exclusively via the HFJV circuit.
Platt
David R
DR
Bunnell Incorporated, Salt Lake City, UT 84115, USA.
Swanton
Doug
D
Blackney
David
D
D000280:Administration, Inhalation; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D006611:High-Frequency Jet Ventilation / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D007442:Intubation, Intratracheal; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage*; D011379:Prognosis; D011659:Pulmonary Gas Exchange; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis / Q000628:therapy*; D012129:Respiratory Function Tests; D018570:Risk Assessment; D016896:Treatment Outcome
D009569:Nitric Oxide