Neurotoxicity following addition of intravenous valproate to lamotrigine therapy.
Reversible neurotoxic symptoms were observed in three adult patients with absence status epilepticus on lamotrigine (LTG) therapy after administration of an IV bolus followed by oral valproic acid (VPA). Neurotoxicity was likely related to elevated serum LTG levels, as improvement correlated with discontinuing or reducing LTG dosage.
Burneo
J G
JG
Epilepsy Division, Department of Neurology, University of Alabama School of Medicine, Birmingham 35294, USA.
Limdi
N
N
Kuzniecky
R I
RI
Knowlton
R C
RC
Mendez
M
M
Lawn
N
N
Faught
E
E
Welty
T E
TE
Prasad
A
A
D000284:Administration, Oral; D000328:Adult; D000641:Ammonia / Q000097:blood; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003221:Confusion / Q000097:blood / Q000139:chemically induced*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004832:Epilepsy, Absence / Q000188:drug therapy; D004829:Epilepsy, Generalized / Q000188:drug therapy*; D005260:Female; D014453:Glucuronosyltransferase / Q000037:antagonists & inhibitors; D006801:Humans; D008658:Inactivation, Metabolic; D007275:Injections, Intravenous; D000077213:Lamotrigine; D008875:Middle Aged; D013226:Status Epilepticus / Q000188:drug therapy*; D014227:Triazines / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood / Q000494:pharmacology
D000927:Anticonvulsants; D014227:Triazines; D014635:Valproic Acid; D000641:Ammonia; D014453:Glucuronosyltransferase; D000077213:Lamotrigine