Some new bi- and ter-benzimidazole derivatives as topoisomerase I inhibitors.
The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. In the last years detailed investigation of bi- and ter-benzimidazole derivatives revealed that these compounds are a new class of topoisomerase I inhibitors that poisons mammalian topoisomerase I. In this context a survey about topoisomerase I poisoning activity and cytotoxicity of bi- and ter-benzimidazoles is given. Moreover some recent results about new derivatives, some structure-activity relationships and comparison of activity of various functional groups are discussed.
Alper
Sabiha
S
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University 06100 Tandogan, Ankara, Turkey.
Temiz Arpaci
Ozlem
O
Sener Aki
Esin
E
Yalçin
Ismail
I
D001562:Benzimidazoles / Q000737:chemistry*; D001703:Biophysics / Q000639:trends; D002166:Camptothecin / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors
D001562:Benzimidazoles; D059004:Topoisomerase I Inhibitors; D002166:Camptothecin