title: [Expression and significance of proliferation marker and apoptosis-related genes in benign and malignant epithelial lesions of the larynx].
abstract: OBJECTIVE
  In order to study the ki-67, bcl-2, bax proteins expression and significance in the benign and malignant epithelium of the larynx.
  
  
  METHODS
  An immunohistochemical S-P assay was used to detect the expression of ki-67, bcl-2, bax in LSCCs, epithelial dysplasia, papillomas, simple hyperplasia and normal laryngeal epithelium.
  
  
  RESULTS
  The mean value of ki-67 was 52.0%, 50.0%, 47.8%, 41.6%, 10.0% respectively. The different was statistically significant between LSCCS or dysplasia and normal laryngeal epithelial (P < 0.05). The mean value of bcl-2 was 44.0% in LSCCs, 11.0% in dysplasia, 0% in other three epithelial lesions of the larynx. Bcl-2 was highly positive in LSCCs compared to the other lesions (P < 0.05, P < 0.01, P < 0.01). The expression of bax was 76.0%, 77.8%, 69.6%, 58.3%, 80.0%. In papillomas, there was statistically significant positive correlation between Bcl-2 and ki-67.
  
  
  CONCLUSIONS
  Ki-67 and Bcl-2 coexpression may play a role in the uncontrolled proliferation in papillomas. Ki-67, bax, Bcl-2 could help in estimation the premalignant stages of the larynx.
authors.affiliation: Department of Otolaryngology, Children's Hospital, Chongqing Medical University, Chongqing 400014.
authors.forename: Yan
authors.initials: Y
authors.lastname: Bai
authors.forename: Suling
authors.initials: S
authors.lastname: Hong
authors.forename: Zhennian
authors.initials: Z
authors.lastname: Peng
mesh_terms: D017209:Apoptosis / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D019254:Genes, bcl-2; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D010212:Papilloma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D051028:bcl-2-Associated X Protein
chemical_list: C494826:BAX protein, human; D019394:Ki-67 Antigen; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein