Association of liver steatosis with lipid oversecretion and hypotriglyceridaemia in C57BL/6j mice fed trans-10,cis-12-linoleic acid.
Conjugated linoleic acids (CLA) have recently been recognized to reduce body fat and plasma lipids in some animals. This study demonstrated that the steatosis accompanying the fat loss induced by trans-10,cis-12-C(18:2) (CLA2) and not cis-9,trans-11-C(18:2) (CLA1) isomer in C57BL/6j mice was not due to an alteration of the liver lipoprotein production that was even increased. The 3-fold decrease in plasma triacylglycerol contents and the induction of mRNA expression of low-density lipoprotein receptors concomitantly observed in CLA2-fed mice suggested an increase in the lipoprotein clearance at the level of the liver itself. CLA1 feeding produced similar but attenuated effects on triglyceridaemia only.
Degrace
Pascal
P
UPRES Lipides et Nutrition EA2422, Université de Bourgogne, 6 bd Gabriel, 21000 Dijon, France.
Demizieux
Laurent
L
Gresti
Joseph
J
Chardigny
Jean-Michel
JM
Sébédio
Jean-Louis
JL
Clouet
Pierre
P
D000818:Animals; D001483:Base Sequence; D001835:Body Weight; D017931:DNA Primers; D004951:Esterification; D005227:Fatty Acids / Q000378:metabolism; D005234:Fatty Liver / Q000209:etiology / Q000378:metabolism*; D019787:Linoleic Acid / Q000008:administration & dosage*; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009206:Myocardium / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D014280:Triglycerides / Q000097:blood*
D017931:DNA Primers; D005227:Fatty Acids; D008079:Lipoproteins, VLDL; D012333:RNA, Messenger; D014280:Triglycerides; D019787:Linoleic Acid