title: Airway infections in infancy and the presence of allergy and asthma in school age children.
abstract: OBJECTIVE
  To investigate the association between a history of otitis media and respiratory tract infections in infancy and allergic sensitisation and asthma in school age children of atopic and non-atopic parents.
  
  
  METHODS
  Based on a survey of 4585 schoolchildren, three groups of children aged 6-16 years were selected, of whom 502 were eligible with complete data: (1) diagnosed asthma (n = 166); (2) wheeze within past 12 months (n = 155); and (3) no asthma/no wheeze (n = 181). This study population was further analyzed by subgroups of children with or without parental atopy. Main outcome measures were allergic sensitisation verified by skin prick test and asthma.
  
  
  RESULTS
  Children of atopic parents had a reduced risk of developing allergic sensitisation in school age if they had a combined history of both otitis media and lower respiratory tract infections during infancy (adjusted odds ratio (aOR) 0.13, 95% CI 0.03 to 0.50) or a history of otitis media (aOR 0.31, 95% CI 0.12 to 0.83). A history of lower respiratory tract infections in infancy increased the risk of asthma in children of non-atopic parents (aOR 4.21, 95% CI 1.68 to 10.57).
  
  
  CONCLUSIONS
  In the present study population, a history of otitis media in infancy seems to be negatively associated with allergic sensitisation in school age children of atopic parents, whereas a history of lower respiratory tract infections was positively associated with asthma in children of non-atopic parents.
authors.affiliation: Geilomo Children's Hospital for Asthma and Allergy, Geilo and Sandvika, Norway. fnja@online.no
authors.forename: F
authors.initials: F
authors.lastname: Njå
authors.forename: W
authors.initials: W
authors.lastname: Nystad
authors.forename: O
authors.initials: O
authors.lastname: Hetlevik
authors.forename: K C
authors.initials: KC
authors.lastname: Lødrup Carlsen
authors.forename: K-H
authors.initials: KH
authors.lastname: Carlsen
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000209:etiology* / Q000235:genetics; D002648:Child; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics; D007223:Infant; D008297:Male; D016017:Odds Ratio; D010033:Otitis Media / Q000150:complications*; D012008:Recurrence; D012135:Respiratory Sounds / Q000209:etiology / Q000235:genetics; D012141:Respiratory Tract Infections / Q000150:complications*; D012307:Risk Factors; D012882:Skin Tests