title: p53 autoantibodies as tumor marker in head and neck squamous cell cancer.
abstract: p53 autoantibodies (AAB) are a new serological parameter with unknown potential in patients with malignancies. The reason why and the mechanism by which they develop is still unclear. So far, only in a limited number of studies has the usefulness of p53 AAB in the follow-up of cancer patients been shown. In this study 32 patients with head and neck cancer, seropositive for p53 AAB in their serum detected with an ELISA, were followed-up for at least 42 months. In 9 out of 32 p53 seropositive AAB head and neck cancer patients a correlation with the clinical course of the disease was seen. The remaining 23 of the p53 AAB-positive patients did not demonstrate any significant AAB titer changes during the follow-up and no significant correlation with the clinical course was observed. In conclusion, the clinical value of p53 AAB as a tumor marker for patients with head and neck cancer seems to be limited.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Clinic Kiel, Arnold-Heller-Str. 14, 24105 Kiel, Germany. gottschlich@hno.uni-kiel.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Gottschlich
authors.forename: Markus
authors.initials: M
authors.lastname: Hoffmann
authors.forename: Jan D
authors.initials: JD
authors.lastname: Maass
authors.forename: Tibor
authors.initials: T
authors.lastname: Görörgh
authors.forename: Volker
authors.initials: V
authors.lastname: Buhmann
authors.forename: Asita
authors.initials: A
authors.lastname: Hoffmann-Fazel
authors.forename: Heinrich
authors.initials: H
authors.lastname: Rudert
authors.forename: Steffen
authors.initials: S
authors.lastname: Maune
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D015203:Reproducibility of Results; D016159:Tumor Suppressor Protein p53 / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53