title: Follicular cholangitis: another cause of benign biliary stricture.
abstract: The case of a 57-year-old woman with a benign biliary stricture is described. Radiological examinations showed granularly elevated lesions in the common hepatic duct and severe stenosis at the hepatic hilum. Under a tentative diagnosis of hepatic hilar bile duct cancer, the patient underwent extended right hepatectomy with bile duct resection. However, pathological and immunohistochemical studies revealed a benign stricture with remarkable formation of lymph follicles with germinal centers, which could be termed "follicular cholangitis". This is the first case report of this uncommon presentation of inflammatory changes of the bile duct. Its etiology was unknown, and more investigation is encouraged to clarify its relationship to systemic disorders and malignancies. As difficulty remains in discriminating between benign and malignant strictures by nonsurgical modalities at present, surgical resection without complications provides a feasible approach to such a benign lesion.
authors.affiliation: Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo University Hospital, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8655, Japan. AOKI-2SU@h.u-tokyo.ac.jp
authors.forename: Taku
authors.initials: T
authors.lastname: Aoki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kubota
authors.forename: Teruaki
authors.initials: T
authors.lastname: Oka
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hirai
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Makuuchi
mesh_terms: D002760:Cholangiopancreatography, Endoscopic Retrograde; D001651:Cholestasis, Extrahepatic / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006500:Hepatic Duct, Common / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008221:Lymphoid Tissue / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D014057:Tomography, X-Ray Computed