title: International expert panel on the use of primary (preoperative) systemic treatment of operable breast cancer: review and recommendations.
abstract: Primary systemic therapy (PST) represents the standard of care in patients with locally advanced breast cancer. In addition, there is increasing information on PST in operable breast disease that supports the use of PST in routine practice. However, current regimens and techniques vary. To address this concern, a group of representatives from breast cancer clinical research groups in France, Germany, Italy, the United Kingdom, and the United States reviewed all available data on prospective randomized trials in this setting. Recommendations are made regarding terminology, indications, regimen, diagnosis before treatment, monitoring of efficacy, tumor localization, surgery, pathologic evaluation, and postoperative treatment.
authors.affiliation: Department of Gynecology and Obstetrics, Goethe University, Frankfurt am Main, Germany. M.Kaufmann@em.uni-frankfurt.de
authors.forename: Manfred
authors.initials: M
authors.lastname: Kaufmann
authors.forename: Gunter
authors.initials: G
authors.lastname: von Minckwitz
authors.forename: Roy
authors.initials: R
authors.lastname: Smith
authors.forename: Vicente
authors.initials: V
authors.lastname: Valero
authors.forename: Luca
authors.initials: L
authors.lastname: Gianni
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Eiermann
authors.forename: Anthony
authors.initials: A
authors.lastname: Howell
authors.forename: Serban Dan
authors.initials: SD
authors.lastname: Costa
authors.forename: Philippe
authors.initials: P
authors.lastname: Beuzeboc
authors.forename: Michael
authors.initials: M
authors.lastname: Untch
authors.forename: Jens-Uwe
authors.initials: JU
authors.lastname: Blohmer
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Sinn
authors.forename: Rolf
authors.initials: R
authors.lastname: Sittek
authors.forename: Rainer
authors.initials: R
authors.lastname: Souchon
authors.forename: Augustinos H
authors.initials: AH
authors.lastname: Tulusan
authors.forename: Tanja
authors.initials: T
authors.lastname: Volm
authors.forename: Hans-Jörg
authors.initials: HJ
authors.lastname: Senn
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D007391:International Cooperation; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic