title: Chemoprevention of cancerogenesis--the role of sulforaphane.
abstract: Isothiocyanates are a group of naturally occurring compounds with interesting medical properties, such as antimicrobial, antioxidant and antitumor activities. In our work we were trying to present the tumoricidal activity of new synthesized derivatives of one isothiocyanate: 1-isothio-cyanato-(4R)-(methylsulfinyl) butane [sulforaphane]. Many chemical substances derived from plants, undoubtedly have protective properties. The effectiveness of sulforaphane is based on induction of hepatic detoxifying enzymes.
authors.affiliation: Medical University of Warsaw, Department of General and Transplantation Surgery, 59 Nowogrodzka Str., 02-006 Warsaw. esolowiej@poczta.onet.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Sołowiej
authors.forename: Teresa
authors.initials: T
authors.lastname: Kasprzycka-Guttman
authors.forename: Piotr
authors.initials: P
authors.lastname: Fiedor
authors.forename: Wojciech
authors.initials: W
authors.lastname: Rowinśki
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry; D005978:Glutathione / Q000378:metabolism; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D006801:Humans; D017879:Isothiocyanates; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D013454:Sulfoxides; D013861:Thiocyanates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D016588:Anticarcinogenic Agents; D000975:Antioxidants; D017879:Isothiocyanates; D013454:Sulfoxides; D013861:Thiocyanates; D006419:Heme Oxygenase (Decyclizing); C016766:sulforaphane; D005978:Glutathione