title: Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor.
abstract: Variability in valacyclovir bioavailability and the potential for cephalexin-valacyclovir interaction were evaluated. The intraindividual acyclovir area under the concentration-time curve (AUC) varied minimally, whereas interindividual differences were substantial. Coadministration of the human peptide transporter 1 (hPEPT1) substrates valacyclovir and cephalexin minimally reduced the acyclovir AUC. These results suggest a stable valacyclovir absorption phenotype, significant interindividual variability, and minimal interaction between these hPEPT1 substrates.
authors.affiliation: School of Pharmacy, University of California, San Francisco, California 94143, USA.
authors.forename: Dana D
authors.initials: DD
authors.lastname: Phan
authors.forename: Peter
authors.initials: P
authors.lastname: Chin-Hong
authors.forename: Emil T
authors.initials: ET
authors.lastname: Lin
authors.forename: Pascale
authors.initials: P
authors.lastname: Anderle
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Sadee
authors.forename: B Joseph
authors.initials: BJ
authors.lastname: Guglielmo
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D002506:Cephalexin / Q000008:administration & dosage*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D000074011:Peptide Transporter 1; D027981:Symporters; D000077483:Valacyclovir; D014633:Valine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D002352:Carrier Proteins; D000074011:Peptide Transporter 1; C082186:SLC15A1 protein, human; D027981:Symporters; D014633:Valine; D000077483:Valacyclovir; D002506:Cephalexin; D000212:Acyclovir