Morierinin: a new cytotoxic cucurbitacin from the leaves of Morierina montana Vieill.
An extract of the leaves of Morierina montana collected in New Caledonia was found to be cytotoxic for KB cells. A bioassay-guided fractionation procedure led to the isolation of a series of cucurbitacins of which one, morierinin (1), is new. The isolation and structure elucidation of 1 are described.
Litaudon
Marc
M
Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France. litaudon@icsn.cnrs-gif.fr
Gaspard
Christianne
C
Sévenet
Thierry
T
D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry*; D019666:Rubiaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification*
D010936:Plant Extracts; D014315:Triterpenes; C478087:morierinin; C041246:cucurbitacin B; C102326:cucurbitacin E; C478086:23,24-dihydrocucurbitacin B