The effect of selected membrane active substances on erythrocyte deformability.
Aminoguanidine improved the erythrocyte filterability by 4%, pyridoxyliden-aminoguanidine by 11% and pyridoxal by 13% in healthy subjects. In diabetic patients the aminoguanidine effect on erythrocyte filterability was improved by 7%, PAG effect by 9% and pyridoxal effect by 15% in comparison to the control group. The other investigated haematological variables in both groups were within the range of the physiological standard. All of the tested substances demonstrated a mild protective influence on erythrocyte elasticity both in healthy subjects and diabetic patients. Significant elasticity improvement was obtained only by pyridoxal (p<0.01) in patients with diabetes mellitus. (Fig. 4, Ref. 18.).
Beder
I
I
Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia. beder@fmed.uniba.sk
Kittova
M
M
Mataseje
A
A
Carsky
J
J
Orszaghova
Z
Z
Babinska
K
K
D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D004907:Erythrocyte Deformability / Q000187:drug effects*; D004910:Erythrocyte Membrane / Q000187:drug effects*; D006146:Guanidines / Q000494:pharmacology*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D011730:Pyridoxal / Q000031:analogs & derivatives / Q000494:pharmacology*
D000975:Antioxidants; D006146:Guanidines; D006454:Hemoglobins; C471830:aminoguanidine pyridoxal adduct; D011730:Pyridoxal; C004479:pimagedine