Inhibitory effect of NO-releasing ciprofloxacin (NCX 976) on Mycobacterium tuberculosis survival.
Here, we report the antimycobacterial activity of NCX 976, a new molecule obtained adding a NO moiety to the fluoroquinolone ciprofloxacin, on Mycobacterium tuberculosis H37Rv strain, both in a cell-free model and in infected human macrophages. Unlike unaltered ciprofloxacin, NCX976 displayed a marked activity also at low-nanomolar concentrations.
Ciccone
R
R
Department of Biology, University of Rome "Tor Vergata," Bresso, Milan, Italy.
Mariani
F
F
Cavone
A
A
Persichini
T
T
Venturini
G
G
Ongini
E
E
Colizzi
V
V
Colasanti
M
M
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002474:Cell-Free System; D002939:Ciprofloxacin / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D008264:Macrophages / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D009569:Nitric Oxide / Q000737:chemistry*
D000890:Anti-Infective Agents; D009569:Nitric Oxide; D002939:Ciprofloxacin