title: Anti-inflammatory effect of the hydralcoholic extract of Zingiber officinale rhizomes on rat paw and skin edema.
abstract: Plant extracts have been used for centuries as a popular mode of treatment for several health disorders. Over the last ten years, the study of those extracts has attracted attention in different fields of the biological sciences. Ginger, the rhizome of Zingiber officinale Roscoe (Zingiberaceae), is a commom constituent of diet worldwide and it has been reported that its extracts present some pharmacological activities. Here we investigate the effects of the crude hydralcoholic extract of ginger rhizomes on the classical models of rat paw and skin edema. The carrageenan-, compound 48/80- or serotonin-induced rat paw edema were inhibited significantly by the intraperitoneal administration of alcoholic ginger extract. Ginger extract was also effective in inhibiting 48/80-induced rat skin edema at doses of 0.6 and 1.8 mg/site. Rat skin edema induced by substance P or bradikinin was not affected by treatment with Z. officinalle extract. The intraperitoneal administration of ginger extract (186 mg/kg(-1) body wt.) 1 h prior to serotonin injections, reduced significantly the serotonin-induced rat skin edema. Our results demonstrated that crude extract of Zingiber officinale was able to reduce rat paw and skin edema induced by carrageenan, 48/80 compound and serotonin. The antiedematogenic activity seems to be related, at least partially, to an antagonism of the serotonin receptor.
authors.affiliation: Laboratório de Farmacologia e Experimentação Animal, Instituto de Pesquisa e Desenvolvimento--IP&D, Universidade do Vale do Paraíba--UNIVAP, Urbanova, São José dos Campos, SP, Brazil.
authors.forename: S C
authors.initials: SC
authors.lastname: Penna
authors.forename: M V
authors.initials: MV
authors.lastname: Medeiros
authors.forename: F S C
authors.initials: FS
authors.lastname: Aimbire
authors.forename: H C C
authors.initials: HC
authors.lastname: Faria-Neto
authors.forename: J A A
authors.initials: JA
authors.lastname: Sertié
authors.forename: R A B
authors.initials: RA
authors.lastname: Lopes-Martins
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D020939:Zingiber officinale / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D027343:Rhizome / Q000737:chemistry*; D012701:Serotonin / Q000494:pharmacology; D012867:Skin / Q000187:drug effects / Q000473:pathology; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012701:Serotonin; D003189:p-Methoxy-N-methylphenethylamine