title: [Septic shock due to congenital disseminated toxoplasmosis?].
abstract: Congenital toxoplasmosis secondary to maternal primary infection acquired late during pregnancy is generally asymptomatic at birth. We report a case of a newborn infant whose mother had been infected between the 27th and the 33rd week of gestation. No treatment had been given during gestation. The infant had a disseminated form of toxoplasmosis with hepatosplenomegaly, pneumonitis, purpura, hepatitis. On the third day of life, he developed shock. The patient died early despite therapy. Septic shock is unusual in congenital toxoplasmosis, although it has been described in immunocompromised patients, notably in patients infected with the human immunodeficiency virus.
authors.affiliation: Service de médecine néonatale, hôpital Saint-Antoine, GHICL Lille, 59000, Lille, France. fabrice.cneude@free.fr <fabrice.cneude@free.fr>
authors.forename: F
authors.initials: F
authors.lastname: Cneude
authors.forename: R
authors.initials: R
authors.lastname: Deliège
authors.forename: C
authors.initials: C
authors.lastname: Barbier
authors.forename: I
authors.initials: I
authors.lastname: Durand-Joly
authors.forename: A
authors.initials: A
authors.lastname: Bourlet
authors.forename: M
authors.initials: M
authors.lastname: Sonna
authors.forename: R
authors.initials: R
authors.lastname: El Kohen
authors.forename: A
authors.initials: A
authors.lastname: Locquet
authors.forename: G
authors.initials: G
authors.lastname: Vittu
authors.forename: A
authors.initials: A
authors.lastname: Decoster
mesh_terms: D017809:Fatal Outcome; D005260:Female; D005440:Fluid Therapy; D006505:Hepatitis / Q000469:parasitology; D006529:Hepatomegaly / Q000469:parasitology; D006611:High-Frequency Jet Ventilation; D006801:Humans; D016867:Immunocompromised Host; D007231:Infant, Newborn; D017713:Platelet Transfusion; D011014:Pneumonia / Q000469:parasitology; D011693:Purpura / Q000469:parasitology; D012772:Shock, Septic / Q000469:parasitology* / Q000628:therapy; D013163:Splenomegaly / Q000469:parasitology; D013921:Thrombocytopenia / Q000469:parasitology; D014125:Toxoplasmosis, Congenital / Q000150:complications* / Q000175:diagnosis / Q000276:immunology