title: Three new cytotoxic acylspermidines from the soft coral, Sinularia sp.
abstract: Three new acylated spermidines and two known related compounds were isolated from the Okinawan soft coral, Sinularia sp. These compounds were N',N",N"-trimethylspermidines that are acylated by a methyl-branched unsaturated fatty acid. These acylspermidines showed potent cytotoxicity against human tumor cell lines at an IC(50) value of 17 ng/ml and the induction of apoptotic phenomena.
authors.affiliation: Graduate School of Bioagricultural Sciences, Nagoya University, Chijusa-ku, Nagoya 464-8601, Japan. ojika@agr.nagoya-u.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Ojika
authors.forename: Mohammad Kamrul
authors.initials: MK
authors.lastname: Islam
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Shintani
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Okamoto
authors.forename: Youji
authors.initials: Y
authors.lastname: Sakagami
mesh_terms: D000215:Acylation; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005231:Fatty Acids, Unsaturated; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013095:Spermidine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology*; D014118:Toxins, Biological / Q000302:isolation & purification*
chemical_list: D000970:Antineoplastic Agents; D005231:Fatty Acids, Unsaturated; D014118:Toxins, Biological; D013095:Spermidine