Phosphoinositide 3-kinase-dependent activation of Rac.
The monomeric GTPase Rac and the lipid kinase phosphoinositide 3-kinase (PI3K) are intracellular signalling enzymes that each regulate a huge range of cellular functions. Their signalling pathways overlap. Several pathways lead from PI3K activation via the production of the lipid second messenger phosphatidylinositol (3,4,5)-triphosphate (PtdIns(3,4,5)P(3)) to the activation of guanine-nucleotide exchange factors (GEFs) that activate Rac. Vice versa, Rac can also stimulate the activation of PI3K, although the mechanism for this is unclear. We review here the evidence that links PI3K and Rac signalling pathways.
Welch
Heidi C E
HC
Inositide Laboratory, Signalling Programme, The Babraham Institute, Cambridge CB2 4AT, UK. heidi.welch@bbsrc.ac.uk
Coadwell
W John
WJ
Stephens
Len R
LR
Hawkins
Phillip T
PT
D000818:Animals; D004789:Enzyme Activation; D005544:Forecasting; D020558:GTP Phosphohydrolases / Q000378:metabolism; D020662:Guanine Nucleotide Exchange Factors / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D018129:Phosphatidylinositol Phosphates / Q000037:antagonists & inhibitors; D017434:Protein Structure, Tertiary; D015290:Second Messenger Systems; D015398:Signal Transduction; D020744:rac GTP-Binding Proteins / Q000378:metabolism*
D020662:Guanine Nucleotide Exchange Factors; D018129:Phosphatidylinositol Phosphates; C060974:phosphatidylinositol 3,4,5-triphosphate; D019869:Phosphatidylinositol 3-Kinases; D020558:GTP Phosphohydrolases; D020744:rac GTP-Binding Proteins