Melanin biosynthesis inhibitors from the bark of Machilus thunbergii.
The bioassay-guided fractionation of the methylene chloride soluble portion of a methanol extract of Machilus thunbergii bark led to the isolation of four known lignans, machilin A (1), meso-monomethyl dihydroguaiaretic acid (2), nectandrin A (3) and nectandrin B (4), which exhibited potent inhibitory activity on melanin biosynthesis in cultured B-16 mouse melanoma cells (IC(50): 39.9, 15.1, 19.4 and 37.8 microM, respectively).
Li
Gao
G
College of Pharmacy, Yeungnam University, Gyongsan, Korea.
Ju
Hye Kyung
HK
Chang
Hyuen Wook
HW
Jahng
Yurngdong
Y
Lee
Seung-Ho
SH
Son
Jong-Keun
JK
D000818:Animals; D045744:Cell Line, Tumor / Q000187:drug effects / Q000378:metabolism; D019770:Lauraceae; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000378:metabolism; D051379:Mice; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D008543:Melanins; D010936:Plant Extracts