Change in the concentration of vitamins C and E in rat tissues by paraquat administration.
Paraquat causes lung injury by oxidative stress. After 48 h of intraperitoneal administration of paraquat (50 mg/kg of body weight) to rats, the vitamin C concentration in the lungs was significantly decreased, while lung vitamin E content was increased after 12 h. These results indicate that vitamin C directly reflected the oxidative stress in the lungs.
Ikeda
Kazumi
K
Department of Food Science and Nutrition, Nara Women's University, Nara 630-8506, Japan.
Kumagai
Yumi
Y
Nagano
Yuka
Y
Matsuzawa
Naoko
N
Kojo
Shosuke
S
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000378:metabolism*; D006540:Herbicides / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D010269:Paraquat / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000378:metabolism*
D000975:Antioxidants; D006540:Herbicides; D014810:Vitamin E; D010269:Paraquat; D001205:Ascorbic Acid