Perifusion model for detoxification of drugs in a bioartificial liver.
Detoxification of a drug in a bioartificial liver (BAL) during an in vitro experiment was theoretically carried out based on a perifusion model. The detoxification capacity assay, the rates of disappearance of the chemicals such as flow-limited and enzyme-limited drugs in the BAL system could be defined from models of hepatic perfusion-elimination relationships. When the flow-limited drug administrated under a quasi-equilibrium condition, a two-compartment model for the concentration behavior of the drug was introduced and compared with a one-compartment model. For both models, equations involving hepatic drug clearance and various pharmacokinetic parameters were derived under initial bolus loading and constant-rate infusion plus bolus loading conditions. The concentration of enzyme-limited drug in the BAL decreased linearly with time in contrast with the concentration profile of the flow-limited drug followed by exponential functions. The perifusion model offers a quantitative understanding of the elimination kinetics of chemicals such as flow-limited and enzyme-limited drugs in a bioartificial liver and a comparison between the BAL and human liver.
Park
Y G
YG
Research Institute of Medical Sciences, Chonnam National University, Gwangju, Korea.
Son
Y S
YS
Ryu
H W
HW
D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics; D005690:Galactose / Q000493:pharmacokinetics; D006801:Humans; D008658:Inactivation, Metabolic; D008012:Lidocaine / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism; D019164:Liver, Artificial; D008657:Metabolic Clearance Rate; D008954:Models, Biological
D000889:Anti-Arrhythmia Agents; D008012:Lidocaine; D005690:Galactose