Further degradation product of hyperforin from Hypericum perforatum (St John's Wort).
Repeated examination of the aerial parts of Hypericum perforatum yielded a new degradation product of hyperforin (1) namely deoxyfurohyperforin A (2), together with the previously identified furohyperforin (3), furoadhyperforin (4), furohyperforin A (5a and 5b), pyrano[7,28-b]hyperforin (6) and 3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3-pentenyl)-cyclohexanone (7). The antimicrobial activity of the compounds 3, 5a and 5b, 6 and 7 was tested against Staphylococcus aureus, Candida albicans, Bacillus subtilis and Escherichia coli.
Vajs
V
V
Institute of Chemistry, Technology and Metallurgy, Njegoseva 12, Serbia and Montenegro, Belgrade 11000, Yugoslavia.
Vugdelija
S
S
Trifunović
S
S
Karadzić
I
I
Juranić
N
N
Macura
S
S
Milosavljević
S
S
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001412:Bacillus subtilis / Q000187:drug effects; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D020902:Hypericum; D008826:Microbial Sensitivity Tests; D010696:Phloroglucinol / Q000031:analogs & derivatives; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D013211:Staphylococcus aureus / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D010936:Plant Extracts; D013729:Terpenes; C476869:deoxyfurohyperforin A; D010696:Phloroglucinol; C001654:hyperforin