Josef Rudinger Memorial Lecture 2002. The chemistry of the opioid receptor binding sites.
Since the discovery of the opioid receptors and their endogenous ligands an immense research work has been devoted to the exploration of their specificity, the mechanism of ligand binding and ligand-receptor interactions. One of the main goals has been the location and characterization of the binding sites. The present review compiles the results achieved in this field in the last quarter of a century, and puts some questions concerning the success of these efforts.
Medzihradszky
Kálmán
K
Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Budapest, Hungary. medzy@szerves.chem.elte.hu
D000345:Affinity Labels / Q000737:chemistry; D000590:Amino Acid Chloromethyl Ketones / Q000494:pharmacology; D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D003978:Diazomethane / Q000031:analogs & derivatives* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006639:Histidine / Q000737:chemistry; D008024:Ligands; D008301:Maleimides / Q000494:pharmacology; D015394:Molecular Structure; D011957:Receptors, Opioid / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000378:metabolism / Q000494:pharmacology
D000345:Affinity Labels; D000590:Amino Acid Chloromethyl Ketones; D004791:Enzyme Inhibitors; D008024:Ligands; D008301:Maleimides; D011957:Receptors, Opioid; D013438:Sulfhydryl Compounds; C015795:diazomethyl ketones; D006639:Histidine; D003978:Diazomethane