title: [Immunohistochemical study of thrombomodulin expression in multiple organs dysfunction syndrome].
abstract: OBJECTIVE
  To study the expression of thrombomodulin (TM) and its significance in the pathogenesis of multiple organs dysfunction syndrome (MODS).
  
  
  METHODS
  TM expression was determined by immunohistochemical staining in 20 autopsy cases with MODS group and 12 autopsy cases without MODS (control group).
  
  
  RESULTS
  Significant differences in positive expression of TM in heart, lungs and kidneys were found between the control group and MODS group (all P<0.01).
  
  
  CONCLUSIONS
  The increase of TM secretion results in homeostatic disturbance, which might be one of the important mechanisms of MODS.
authors.affiliation: Department of Forensic Pathology, Zhongshan University of Medical Sciences, Guangzhou 510080, Guangdong, China.
authors.forename: Si-min
authors.initials: SM
authors.lastname: Luo
authors.forename: Hua-lan
authors.initials: HL
authors.lastname: Jing
authors.forename: Ri-yun
authors.initials: RY
authors.lastname: Wu
authors.forename: Can-qiu
authors.initials: CQ
authors.lastname: Chen
authors.forename: Xiao
authors.initials: X
authors.lastname: Jia
authors.forename: Yan-rong
authors.initials: YR
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000737:chemistry / Q000473:pathology; D008168:Lung / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000737:chemistry / Q000473:pathology; D011379:Prognosis; D018180:Thrombomodulin / Q000032:analysis*
chemical_list: D018180:Thrombomodulin