High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine.
Dipeptidyl peptidase IV is a multifunctional type II transmembrane serine protease glycoprotein. The high-resolution crystal structure of the homodimeric human apo dipeptidyl peptidase IV has been determined at 1.9 A resolution. In addition, the structure of the binary complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine has been solved, revealing the nature of the covalent interaction with the active-site serine.
Oefner
Christian
C
Morphochem AG, Basel, Switzerland. christian.oefner@morphochem.ch
D'Arcy
Allan
A
Mac Sweeney
Aengus
A
Pierau
Sabine
S
Gardiner
Rana
R
Dale
Glenn E
GE
D000631:Aminopyridines / Q000737:chemistry*; D001051:Apoenzymes / Q000737:chemistry; D001665:Binding Sites; D003460:Crystallization; D018360:Crystallography, X-Ray; D018819:Dipeptidyl Peptidase 4 / Q000737:chemistry* / Q000302:isolation & purification; D004791:Enzyme Inhibitors / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D011485:Protein Binding; D011487:Protein Conformation; D011759:Pyrrolidines / Q000737:chemistry*
C482908:1-(((2-((5-iodopyridin-2-yl)amino)ethyl)amino)acetyl)-2-cyanopyrrolidine; D000631:Aminopyridines; D001051:Apoenzymes; D004791:Enzyme Inhibitors; D011759:Pyrrolidines; D018819:Dipeptidyl Peptidase 4