title: Control of tRNA function by antisense PNA derivatives.
abstract: The interaction of antisense peptide nucleic acid (PNA) with yeast tRNA(Phe) was investigated. A 6-mer PNA complementary to the 3'-terminal sequence including the 73ACCA end hybridized to the tRNA. While the PNA with a single mismatch did not. PNA is a promising candidate for controlling tRNA functions by the sequence-specific hybridization.
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, 3-1-1 Tsushimanaka, Okayama 700-8530, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ninomiya
authors.forename: T
authors.initials: T
authors.lastname: Endo
authors.forename: T
authors.initials: T
authors.lastname: Hohsaka
authors.forename: M
authors.initials: M
authors.lastname: Sisido
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000737:chemistry; D016375:Antisense Elements (Genetics) / Q000737:chemistry* / Q000494:pharmacology; D001483:Base Sequence; D009693:Nucleic Acid Hybridization; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000494:pharmacology; D012343:RNA, Transfer / Q000737:chemistry* / Q000502:physiology
chemical_list: D016375:Antisense Elements (Genetics); D020135:Peptide Nucleic Acids; D012343:RNA, Transfer; D000604:Amino Acyl-tRNA Synthetases