[Effects of cardiovascular risk factors on hemorheologic parameters in cerebrovascular patients].
BACKGROUND
Hemorheological factors are of significance in the determination of flow characteristics of blood and play an important role in the pathogenesis of cerebrovascular diseases.


OBJECTIVE
In this study the changes of rheological factors--hematocrit (Hct), plasma fibrinogen concentration (PFC), whole blood (WBV) and plasma viscosity (PV), red blood cell aggregation (AI) and deformability and the association between these parameters and cardiovascular risk factors were investigated in 297 patients (173 males, 124 females, mean age: 60 11 years) with chronic phase (3 months after onset) ischemic cerebrovascular diseases, and in 68 healthy volunteers (30 males, 38 females, mean age: 36 6 years).


RESULTS
All investigated hemorheological factors were significantly (p < 0.05-0.0001) elevated in cerebrovascular patients compared to normal controls, the rise in Hct, WBV and PV are some of the most prominent findings. In the group of hypertensive, hyperlipidemic patients, smokers and alcoholics Hct, PFC, WBV, PV and AI were significantly (p < 0.05-0.0001) higher compared to healthy controls, the same factors except plasma fibrinogen concentration showed association with diabetic history. Comparing cerebrovascular patients with or without risk factors, the most severe hemorheological deficit was observed in patients with hyperlipidemia and smoking habits.


CONCLUSIONS
In this study the authors proved in chronic ischemic cerebrovascular patients that hemorheological abnormalities persist in most cases for a long time after an acute stroke, significant correlation could be seen between blood rheology and cardiovascular risk factors. Examination of rheological parameters can support to choose the optimal medical treatment in the secondary prevention of stroke, correction of hemorheological disturbances can reduce the risk of recurrent stroke.
Szapáry
László
L
Pécsi Tudományegyetem, Altalános Orvostudományi Kar, Neurológiai Klinika. szapary@neuro.pote.hu
Szóts
Mónika
M
Horváth
Beáta
B
Márton
Zsolt
Z
Alexy
Tamás
T
Késmárky
Gábor
G
Juricskay
István
I
Nagy
Ferenc
F
Gaál
Valéria
V
Pálfi
Anita
A
Koltai
Katalin
K
Tóth
Kálmán
K
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications; D001809:Blood Viscosity; D002318:Cardiovascular Diseases / Q000097:blood / Q000503:physiopathology*; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000503:physiopathology; D048909:Diabetes Complications; D004903:Erythrocyte Aggregation; D004907:Erythrocyte Deformability; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006400:Hematocrit; D018056:Hemorheology; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D008297:Male; D008875:Middle Aged; D010949:Plasma; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D020521:Stroke / Q000097:blood / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control*
D005340:Fibrinogen