[Cubilin: physiopathologic role and relationship with megalin].
Epithelia which line the renal proximal convoluted tubule, the visceral layer of the yolk sac and the ileum have the ability to internalize a variety of substances which not only serve as nutrients, but may also be transported from one compartment to another. Cubilin, a multiligand receptor, in association with megalin, also a multiligand receptor, appears to be important under both normal and pathological conditions.
Verroust
Pierre J
PJ
Inserm U.538, CHU Saint Antoine, 27, rue de Chaligny, 75012 Paris, France. verroust@infobiogen.fr
Kozyraki
Renata
R
D004068:Digestive System Physiological Phenomena; D005786:Gene Expression Regulation; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000502:physiology*; D008024:Ligands; D026561:Low Density Lipoprotein Receptor-Related Protein-2 / Q000502:physiology*; D008562:Membrane Glycoproteins; D011506:Proteins / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology*; D014805:Vitamin B 12 / Q000378:metabolism
D008024:Ligands; D026561:Low Density Lipoprotein Receptor-Related Protein-2; D008562:Membrane Glycoproteins; D011506:Proteins; D011956:Receptors, Cell Surface; C029486:intrinsic factor-cobalamin receptor; D014805:Vitamin B 12