title: Tissue Doppler analysis is hindered in abnormal wall motion and changes in afterload.
abstract: BACKGROUND
  Tissue Doppler (TD) analysis is used to estimate contractility. However, interference with hemodynamics has not been investigated.
  
  
  OBJECTIVE
  To evaluate the effect of hemodynamic conditions and wall motion abnormalities on TD indices.
  
  
  METHODS
  TD indices were obtained in 16 dogs and correlated with hemodynamics and wall thickening.
  
  
  RESULTS
  An inverse relation between TD indices and systemic vascular resistance was observed when afterload-related parameters were included in the analysis (early systolic subendocardial velocity: r((multiple regression))=0.82, P<0.0001 vs. r((simple regression))=0.57, P=0.0002). Early systolic TD data were more closely related to hemodynamics than those derived from the entire systole. TD data did not correspond to the hyperkinesia of the contralateral wall in myocardial infarction, whereas the increase of gradient parameters reflected hypercontractility (P<0.05).
  
  
  CONCLUSIONS
  TD indices are directly related to contractility and inversely to afterload. They do not reflect wall motion of those segments not involved in regional ischemia.
authors.affiliation: Department of Cardiology, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. silvana.mueller@uibk.ac.at
authors.forename: Silvana
authors.initials: S
authors.lastname: Müller
authors.forename: Thomas
authors.initials: T
authors.lastname: Bartel
authors.forename: Joop
authors.initials: J
authors.lastname: Koopman
authors.forename: Natesa G
authors.initials: NG
authors.lastname: Pandian
authors.forename: Raimund
authors.initials: R
authors.lastname: Erbel
authors.forename: Otmar
authors.initials: O
authors.lastname: Pachinger
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000502:physiology; D004195:Disease Models, Animal; D004285:Dogs; D015150:Echocardiography, Doppler; D025401:Echocardiography, Stress; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology*; D008297:Male; D009068:Movement / Q000502:physiology; D009200:Myocardial Contraction / Q000502:physiology*; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D015203:Reproducibility of Results; D013997:Time Factors