title: Formation of the chromophore of the pyoverdine siderophores by an oxidative cascade.
abstract: The pyoverdine chromophore is formed in a reaction involving a two-electron oxidation, a conjugate addition, and a second two-electron oxidation. This oxidative cascade can be carried out with polyphenol oxidase (PPO), MnO(2), and cell-free extracts from Pseudomonas aeruginosa. [reaction: see text]
authors.affiliation: Department of Chemistry and Chemical Biology, 120 Baker Laboratory, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Pieter C
authors.initials: PC
authors.lastname: Dorrestein
authors.forename: Keith
authors.initials: K
authors.lastname: Poole
authors.forename: Tadhg P
authors.initials: TP
authors.lastname: Begley
mesh_terms: D004156:Catechol Oxidase / Q000737:chemistry / Q000378:metabolism; D009842:Oligopeptides; D010084:Oxidation-Reduction; D010860:Pigments, Biological / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000737:chemistry; D017262:Siderophores / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009842:Oligopeptides; D010860:Pigments, Biological; D017262:Siderophores; C042453:pyoverdin; D004156:Catechol Oxidase