A novel one-pot method for the preparation of pyrazoles by 1,3-dipolar cycloadditions of diazo compounds generated in situ.
A convenient one-pot procedure for the preparation of pyrazoles by 1,3-dipolar cycloaddition of diazo compounds generated in situ has been developed. Diazo compounds derived from aldehydes were reacted with terminal alkynes to furnish regioselectively 3,5-disubstituted pyrazoles. Furthermore, the reaction of N-vinylimidazole and diazo compounds derived from aldehydes gave exclusively 3-substituted pyrazoles in a one-pot process.
Aggarwal
Varinder K
VK
School of Chemistry, Bristol University, Cantock's Close, Bristol BS8 1TS, UK. v.aggarwal@bristol.ac.uk
de Vicente
Javier
J
Bonnert
Roger V
RV