Comparison between the effects of the rapid recombinant insulin analog Lispro (Lys B28, Pro B29) and those of human regular insulin on platelet cyclic nucleotides and aggregation.
Russo
Isabella
I
Diabetes Unit, Department of Clinical and Biological Sciences of the University of Turin, San Luigi Gonzaga Hospital, 10043 Orbassano, Turin, Italy.
Massucco
Paola
P
Mattiello
Luigi
L
Anfossi
Giovanni
G
Trovati
Mariella
M
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000730:Androstadienes / Q000494:pharmacology; D001792:Blood Platelets / Q000737:chemistry / Q000187:drug effects*; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D061268:Insulin Lispro; D008297:Male; D009569:Nitric Oxide / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010974:Platelet Aggregation / Q000187:drug effects*; D011994:Recombinant Proteins / Q000494:pharmacology; D000077191:Wortmannin; D019323:omega-N-Methylarginine / Q000494:pharmacology
D000730:Androstadienes; D004791:Enzyme Inhibitors; D007328:Insulin; D061268:Insulin Lispro; D000081082:Phosphoinositide-3 Kinase Inhibitors; D011994:Recombinant Proteins; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D000244:Adenosine Diphosphate; D000242:Cyclic AMP; D019001:Nitric Oxide Synthase; D006152:Cyclic GMP; D000077191:Wortmannin