title: Localized 1H-MR spectroscopy in moyamoya disease before and after revascularization surgery.
abstract: OBJECTIVE
  To evaluate, using localized proton magnetic resonance spectroscopy ((1)H-MRS), the cerebral metabolic change apparent after revascularization surgery in patients with moyamoya disease.
  
  
  METHODS
  Sixteen children with moyamoya disease and eight age-matched normal controls underwent MR imaging, MR angiography, conventional angiography, and (99m)Tc- ECD SPECT. Frontal white matter and the basal ganglia of both hemispheres were subjected to localized (1)H-MRS, and after revascularization surgery, four patients underwent follow-up (1)H-MRS.
  
  
  RESULTS
  Decreased NAA/Cr ratios (1.35+/-0.14 in patients vs. 1.55+/-0.24 in controls) and Cho/Cr ratios (0.96+/-0.13 in patients vs. 1.10+/-0.11 in controls) were observed in frontal white matter. After revascularization surgery, NAA/Cr and Cho/Cr ratios in this region increased. In the basal ganglia, there is no abnormal metabolic ratios.
  
  
  CONCLUSIONS
  Localized (1)H-MRS revealed abnormal metabolic change in both hemispheres of children with moyamoya disease. Because of its non-invasive nature, (1)H-MRS is potentially useful for the preoperative evaluation of metabolic abnormalities and their postoperative monitoring.
authors.affiliation: Department of Diagnostic Radiology, College of Medicine, Ewha Womans University Hospital, Yangcheon-gu, Seoul, Korea. soomee@mm.ewha.ac.kr
authors.forename: Soo Mee
authors.initials: SM
authors.lastname: Lim
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Choi
authors.forename: Jung Soo
authors.initials: JS
authors.lastname: Suh
authors.forename: Jung Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: Keun Ho
authors.initials: KH
authors.lastname: Lim
authors.forename: Dae Chul
authors.initials: DC
authors.lastname: Suh
authors.forename: Ho Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: Tae-Hwan
authors.initials: TH
authors.lastname: Lim
authors.forename: Young Shin
authors.initials: YS
authors.lastname: Ra
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D016022:Case-Control Studies; D002533:Cerebral Angiography; D002548:Cerebral Revascularization; D002648:Child; D002794:Choline / Q000378:metabolism; D003545:Cysteine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009072:Moyamoya Disease / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery*; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D001224:Aspartic Acid; C000179:N-acetylaspartate; C059659:technetium Tc 99m bicisate; D003545:Cysteine; D002794:Choline