title: An update on the genetics of Gilles de la Tourette syndrome.
abstract: OBJECTIVE
  To summarize the current data suggesting that Gilles de la Tourette syndrome (GTS) is inherited and genetic.
  
  
  METHODS
  The extant literature on family studies, segregation analyses, candidate genes studies and linkage studies of GTS was reviewed and summarized.
  
  
  CONCLUSIONS
  There is considerable data that suggests that: (1). genetic factors play an important role in the manifestation of GTS; (2). several genes are important with some possibly having major effect; and (3). several regions of the genome have been identified as potential locations of these susceptibility genes.
authors.affiliation: Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, 10th Floor, Charlestown, MA 02129, USA. pauls@psych.mgh.harvard.edu
authors.forename: David L
authors.initials: DL
authors.lastname: Pauls
mesh_terms: D008040:Genetic Linkage; D005821:Genetic Techniques; D006801:Humans; D010375:Pedigree; D005879:Tourette Syndrome / Q000235:genetics*