[Effectiveness and mechanism of action of a new plant complex drug in nonspecific inflammatory processes in the bronchopulmonary system].
The elixir Bronchofit is an aqueous-alcoholic extract from 7 kinds of plants. It is a balanced compound, rich in biologically active substances including essential oils and flavonoids, possessing a wide spectrum of pharmacological activity. On the model of frog's palate the elixir enhanced the transport function of the ciliated epithelium. On the model "karragenin edema" bronchofit showed a marked anti-inflammatory activity. A noticeable therapeutic effect was registered in rats with induced bronchopulmonary inflammation. Bronchial secretion contained reduced content of glycosaminoglycans while bronchial lavage did of histamine. Also, bronchofit demonstrated a prominent antioxidative activity, an antibacterial action in relation to Str. pyogenes and Bac. cereus. By a total complex of the activities bronchofit is a promising medicine against bronchopulmonary inflammation.
Aleksandrova
A E
AE
Makarov
V G
VG
Kuznetsov
A S
AS
Vishnevetskaia
T P
TP
Dmitrieva
O L
OL
Kurenkova
T Iu
TIu
Makarova
M N
MN
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001001:Anura; D001992:Bronchoalveolar Lavage Fluid; D001996:Bronchopneumonia / Q000188:drug therapy* / Q000517:prevention & control; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004848:Epithelium / Q000187:drug effects; D006025:Glycosaminoglycans / Q000378:metabolism; D006632:Histamine / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010159:Palate / Q000166:cytology / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D006025:Glycosaminoglycans; D010936:Plant Extracts; D006632:Histamine