Synthesis of small multifunctional molecules having nucleic acid binding property.
We have previously reported that a multifunctional conjugate having the acridine derivative as an intercalative molecule and the polyamine moiety as an RNA cleaving molecule bound to a double helical RNA and cleaved the target efficiently. Along the study to develop a sequence and site specific artificial RNA cleaving molecule, we have development a novel intercalative molecule having polyamine moiety and DNA connecting function. The trisamine-acridine-tethered DNA is expected to bind to the complementary RNA and cleave the phosphodiester bond of the RNA near the position of the built-in interecalator.
Nakanuma
K
K
Department of Chemistry, Faculty of Engineering, Gunma University, Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
Moriguchi
T
T
Suzuki
H
H
Shinozuka
K
K
D000166:Acridines / Q000737:chemistry; D007364:Intercalating Agents / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D012260:Ribonucleases / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D014325:Tromethamine / Q000737:chemistry
D000166:Acridines; D007364:Intercalating Agents; D009838:Oligodeoxyribonucleotides; D014325:Tromethamine; D012313:RNA; D012260:Ribonucleases