title: Inhibitory effect of NO-releasing ciprofloxacin (NCX 976) on Mycobacterium tuberculosis survival.
abstract: Here, we report the antimycobacterial activity of NCX 976, a new molecule obtained adding a NO moiety to the fluoroquinolone ciprofloxacin, on Mycobacterium tuberculosis H37Rv strain, both in a cell-free model and in infected human macrophages. Unlike unaltered ciprofloxacin, NCX976 displayed a marked activity also at low-nanomolar concentrations.
authors.affiliation: Department of Biology, University of Rome "Tor Vergata," Bresso, Milan, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Ciccone
authors.forename: F
authors.initials: F
authors.lastname: Mariani
authors.forename: A
authors.initials: A
authors.lastname: Cavone
authors.forename: T
authors.initials: T
authors.lastname: Persichini
authors.forename: G
authors.initials: G
authors.lastname: Venturini
authors.forename: E
authors.initials: E
authors.lastname: Ongini
authors.forename: V
authors.initials: V
authors.lastname: Colizzi
authors.forename: M
authors.initials: M
authors.lastname: Colasanti
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002474:Cell-Free System; D002939:Ciprofloxacin / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D008264:Macrophages / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development; D009569:Nitric Oxide / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D009569:Nitric Oxide; D002939:Ciprofloxacin