[A case-control study on the vitamin D receptor gene polymorphisms and susceptibility to pulmonary tuberculosis].
OBJECTIVE
To investigate the association between the genetic polymorphisms of VDR gene and susceptibility to pulmonary tuberculosis.


METHODS
Case-control study was conducted. PCR-RFLP technique was used to detect the C/T polymorphism in VDR gene. Information on related factors of tuberculosis was collected using a pre-tested questionnaire. Univariate and multivariate logistic analyses were conducted with SPSS software package.


RESULTS
A sample of 76 cases and 171 controls was studied. The genotype frequencies of VDR-FF, VDR-Ff and VDR-ff were 38.2%, 44.7%, 17.1% and 52.6%, 40.9%, 6.4% respectively. VDR-ff was significantly overrepresented in case group, the OR (95% CI) was 3.668 (1.483 - 9.071) when comparing with FF genotype. The significant association remained after adjusting BCG immunization and smoking, the OR (95% CI) was 3.036 (1.117 - 8.253).


CONCLUSIONS
The VDR-ff genotype might be associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.
Liu
Wei
W
Epidemiological Department of Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Zhang
Cui-ying
CY
Wu
Xiao-ming
XM
Tian
Lei
L
Li
Chun-zhi
CZ
Zhao
Qiu-min
QM
Zhang
Pan-he
PH
Yang
Shu-mei
SM
Yang
Hong
H
Zhang
Xi-tan
XT
Cao
Wu-chun
WC
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
D018167:Receptors, Calcitriol