Modulation of the onset age in primary dystonia by APOE genotype.
APOE polymorphisms were studied in 200 unrelated patients with primary dystonia as well as 300 age-matched control subjects. Although no difference was found in APOE genotype between the patients with dystonia and the controls, APOE-epsilon4 carriers developed the disease on average approximately 10 years earlier than APOE-epsilon4 noncarriers (p = 0.0012). This suggests that APOE-epsilon4 genotype affects the clinical presentation of primary dystonia.
Matsumoto
S
S
Department of Clinical Neuroscience, Tokushima University School of Medicine, Japan. matsumo@medclin.clin.med.tokushima-u.ac.jp
Nishimura
M
M
Sakamoto
T
T
Asanuma
K
K
Izumi
Y
Y
Shibasaki
H
H
Kamatani
N
N
Nakamura
T
T
Kaji
R
R
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002648:Child; D020821:Dystonic Disorders / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
D001057:Apolipoproteins E