title: Chronic obstructive pulmonary disease. 10: Bullectomy, lung volume reduction surgery, and transplantation for patients with chronic obstructive pulmonary disease.
abstract: There are currently three surgical treatments for emphysema: bullectomy, lung transplantation, and lung volume reduction surgery (LVRS). Unfortunately, most emphysema patients are poor candidates for any surgical intervention. A meticulous selection process is favoured in which indications and contraindications are considered and the best solution is devised for each patient. Patients with giant bullae filling half the thoracic volume and compressing relatively normal adjacent parenchyma are offered bullectomy; those with hyperinflation, heterogeneous distribution of destruction, forced expiratory volume in 1 second (FEV(1)) >20%, and a normal carbon dioxide tension (PCO(2)) are offered LVRS; and patients with diffuse disease, lower FEV(1), hypercapnia, and associated pulmonary hypertension are directed towards transplantation. Using these criteria, few patients are serious candidates for surgical procedures. Combinations of LVRS and lung transplantation, either simultaneously or sequentially, are possible but rarely necessary.
authors.affiliation: Division of Cardiothoracic Surgery, Washington University, St Louis, Missouri, USA. meyersb@msnotes.wustl.edu
authors.forename: B F
authors.initials: BF
authors.lastname: Meyers
authors.forename: G A
authors.initials: GA
authors.lastname: Patterson
mesh_terms: D006801:Humans; D016040:Lung Transplantation / Q000379:methods*; D018579:Patient Selection; D011013:Pneumonectomy / Q000379:methods*; D029424:Pulmonary Disease, Chronic Obstructive / Q000601:surgery*; D011656:Pulmonary Emphysema / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome