[A case-control study on the risk factor of perinatals' congenital malformations in seven cities of Guangxi].
OBJECTIVE
To investigate the possible risk factors of congenital malformations in cities of Guangxi.


METHODS
A case-control study was carried out on 281 cases of congenital malformations and 730 controls. Analysis of simple factor and multiple factors unconditional logistic regression were done.


RESULTS
The analysis of simple factor and multiple factors showed that main risk factors of congenital malformations as multiple pregnancies (OR = 2.6), pregnancy complications (OR = 3.2), exposure to chemical substances before or during pregnancy (OR = 3.0), taking sedatives (OR = 10.2), hormone drug (OR = 9.4) or Chinese herbal medicines (OR = 2.5) during the early stage of pregnancy, mothers' blood type as AB (OR = 3.5) or A (OR = 2.2), mothers' emotion being nervous and melancholy (OR = 2.6), mothers' occupation being workers (OR = 3.8) or peasants (OR = 3.0), fathers' exposure to noise (OR = 5.7) or suffering from chronic diseases (OR = 2.8).


CONCLUSIONS
Some risk factors were identified as having important effect on perinatal congenital malformations, including taking sedatives, hormone drug or Chinese herbal medicines during the early stage of pregnancy, mothers' emotion being nervous and melancholy, multiple pregnancies, pregnancy complications, exposure to chemical substances before or during pregnancies, mothers' blood type as AB or A, mothers' occupation being workers or peasants, fathers' exposure to noise or suffering from chronic diseases.
Qiu
Xiao-qiang
XQ
Department of Epidemiology, Public Health College of Guangxi Medical University, Nanning 530021, China.
Zeng
Xiao-yun
XY
Qin
Dan-dan
DD
Zhong
Xi-hong
XH
Lin
Mo-ju
MJ
Zhang
Hong-li
HL
Huang
Dong
D
D016022:Case-Control Studies; D000013:Congenital Abnormalities / Q000209:etiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D012307:Risk Factors