title: Use of trilostane for the treatment of pituitary-dependent hyperadrenocorticism in a cat.
abstract: Hyperadrenocorticism occurs much less frequently in cats than in dogs and, at present, is more difficult to manage successfully. This report documents the use of the steroid synthesis inhibitor trilostane for the treatment of hyperadrenocorticism in a domestic shorthaired cat with pituitary-dependent disease. Although trilostane was able to alleviate the severity of the clinical signs and was well tolerated, the cat subsequently died of renal failure secondary to a fungal infection of the urinary tract.
authors.affiliation: The Queen Mother Hospital for Animals, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA.
authors.forename: B J
authors.initials: BJ
authors.lastname: Skelly
authors.forename: D
authors.initials: D
authors.lastname: Petrus
authors.forename: P K
authors.initials: PK
authors.lastname: Nicholls
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors*; D000308:Adrenocortical Hyperfunction / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D002177:Candidiasis / Q000150:complications / Q000662:veterinary; D002371:Cat Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D002415:Cats; D003645:Death, Sudden / Q000662:veterinary; D003937:Diagnosis, Differential; D013196:Dihydrotestosterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D051437:Renal Insufficiency / Q000150:complications / Q000662:veterinary
chemical_list: D004791:Enzyme Inhibitors; D013196:Dihydrotestosterone; D015096:3-Hydroxysteroid Dehydrogenases; C009954:trilostane