title: Coexisting epithelioid trophoblastic tumor and choriocarcinoma of the uterus following a chemoresistant hydatidiform mole.
abstract: The epithelioid trophoblastic tumor is an unusual type of trophoblastic tumor. Herein, we describe a patient with coexisting epithelioid trophoblastic tumor and choriocarcinoma in the uterus. The patient had a history of hydatidiform mole with recurrent elevation of human chorionic gonadotrophin level that is resistant to chemotherapy. Histopathologic and immunohistochemical examination showed distinctive differences between the 2 trophoblastic tumors. The development of epithelioid trophoblastic tumor may be related to the persistence of locally invasive disease, which was unresponsive to chemotherapy. The patient responded well to surgery. The presence of an epithelioid trophoblastic tumor should be considered in chemoresistant gestational trophoblast tumor.
authors.affiliation: Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong.
authors.forename: Dan-Hua
authors.initials: DH
authors.lastname: Shen
authors.forename: Ui Soon
authors.initials: US
authors.lastname: Khoo
authors.forename: Hextan Y S
authors.initials: HY
authors.lastname: Ngan
authors.forename: Tung-Yau
authors.initials: TY
authors.lastname: Ng
authors.forename: Ming-Tak
authors.initials: MT
authors.lastname: Chau
authors.forename: Wei-Cheng
authors.initials: WC
authors.lastname: Xue
authors.forename: Annie N Y
authors.initials: AN
authors.lastname: Cheung
mesh_terms: D002822:Choriocarcinoma / Q000150:complications / Q000601:surgery; D006063:Chorionic Gonadotropin / Q000097:blood*; D019008:Drug Resistance, Neoplasm; D015622:Epithelioid Cells / Q000187:drug effects / Q000473:pathology*; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D008875:Middle Aged; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D014594:Uterine Neoplasms / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000601:surgery
chemical_list: D006063:Chorionic Gonadotropin