title: Kinetics of diltiazem hydrochloride in solid phase.
abstract: The influence of temperature (353, 358, 363, 368, and 373 K) and relative humidity (76.4, 66.5, 60.5 and 50.9% RH) on the stability of diltiazem hydrochloride in the solid phase was investigated. The decomposition was followed by a HPLC method with UV detection. The kinetic (rate constants, t0.1 and t0.5) and thermodynamic parameters (energy, entalpy and entropy of activation) of the degradation of diltiazem hydrochloride were calculated.
authors.affiliation: Department of Pharmaceutical Chemistry, K. Marcinkowski University of Medical Sciences, 6 Grunwaldzka Str., 60-780 Poznań, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Muszalska
authors.forename: Maciej
authors.initials: M
authors.lastname: Siakowski
mesh_terms: D000465:Algorithms; D002121:Calcium Channel Blockers / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004110:Diltiazem / Q000737:chemistry*; D004355:Drug Stability; D006813:Humidity; D007202:Indicators and Reagents; D007700:Kinetics; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics
chemical_list: D002121:Calcium Channel Blockers; D007202:Indicators and Reagents; D004110:Diltiazem