title: Expression of heat shock protein (Hsp) 70 and Hsp 40 in colorectal cancer.
abstract: Heat shock protein (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. The present study was designed to determine the expression levels of Hsp 70 and Hsp 40 in colorectal cancer by immunohistochemistry and Western blot analysis. Among 50 colorectal cancer tissues studied, 80% and 14% of tumors showed specific immunoreactivity to Hsp 70 and Hsp 40, respectively. Hsp 70 and Hsp 40 were overexpressed in cancer tissue samples compared with normal tissues, on both analytic sets. However, there were no significant correlations between their expression and various clinicopathological parameters of colorectal cancer. Hsp 70 and Hsp 40 may be tumor markers for colorectal cancer.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
authors.forename: Yusei
authors.initials: Y
authors.lastname: Kanazawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Isomoto
authors.forename: Mikio
authors.initials: M
authors.lastname: Oka
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Yano
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Soda
authors.forename: Saburo
authors.initials: S
authors.lastname: Shikuwa
authors.forename: Fuminao
authors.initials: F
authors.lastname: Takeshima
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Omagari
authors.forename: Yohei
authors.initials: Y
authors.lastname: Mizuta
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Murase
authors.forename: Toru
authors.initials: T
authors.lastname: Nakagoe
authors.forename: Kenzo
authors.initials: K
authors.lastname: Ohtsuka
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D015153:Blotting, Western; D015179:Colorectal Neoplasms / Q000378:metabolism*; D005260:Female; D050956:HSP40 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor; D050956:HSP40 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins