title: [Detection of prostate carcinomas with T1-weighted dynamic contrast-enhanced MRI. Value of two-compartment model].
abstract: OBJECTIVE
  The suitability of dynamic parameters of the two-compartment model for detecting prostate carcinomas and its correlation with tumor microvascular density were evaluated.
  
  
  METHODS
  The study included 43 patients with biopsy-proven prostate carcinoma: 28 were examined by 1.0-T MRI (Turbo-FLASH) and 15 by 1.5-T MRI (FLASH) with infusion of 0.1 mmol/kg Gd-DTPA. Signal time curves were parametrized with an open two-compartment model in amplitude and exchange rate constants (k(ep)). The microvascular density of resected prostate carcinomas was determined.
  
  
  RESULTS
  The microvascular density in the tumors was significantly higher than in the adjacent healthy prostate tissue and correlated in both sequences with k(ep). Prostate carcinomas of the peripheral zone were demarcated by amplitude and k(ep). In the Turbo-FLASH sequence there was a significant difference between the tumor tissue and healthy peripheral zone in terms of k(ep) and in the FLASH sequence in terms of amplitude.
  
  
  CONCLUSIONS
  Prostate carcinomas can be visualized with dynamic T1-weighted MR sequences using a two-compartment model. Moreover, the parameter k(ep) reveals the microvascular density in the tumor and can thus provide valuable clinical information for characterizing the tumors.
authors.affiliation: Abteilung für Radiologie, Deutsches Krebsforschungszentrum (DKFZ) Heidelberg. f.kiessling@dkfz-heidelberg.de
authors.forename: F
authors.initials: F
authors.lastname: Kiessling
authors.forename: M
authors.initials: M
authors.lastname: Lichy
authors.forename: R
authors.initials: R
authors.lastname: Grobholz
authors.forename: N
authors.initials: N
authors.lastname: Farhan
authors.forename: M
authors.initials: M
authors.lastname: Heilmann
authors.forename: M S
authors.initials: MS
authors.lastname: Michel
authors.forename: L
authors.initials: L
authors.lastname: Trojan
authors.forename: A
authors.initials: A
authors.lastname: Werner
authors.forename: J
authors.initials: J
authors.lastname: Rabe
authors.forename: S
authors.initials: S
authors.lastname: Delorme
authors.forename: H-U
authors.initials: HU
authors.lastname: Kauczor
authors.forename: H-P
authors.initials: HP
authors.lastname: Schlemmer
mesh_terms: D001706:Biopsy; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000098:blood supply / Q000473:pathology; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA