Emergence of macrolide resistance in throat culture isolates of group a streptococci in Ontario, Canada, in 2001.
Of 500 group A streptococci isolated from pharyngeal swabs, 72 (14.4%) were macrolide resistant, compared to 2.1% in 1997. Of these, 66 (92%) were of the M phenotype and 6 (8.3%) were of the MLS phenotype. Pulsed-field gel electrophoresis found that two clones, with patterns identical to those of serotypes M1 and M4, accounted for 19.4 and 68.1% of the macrolide-resistant isolates, respectively.
Katz
Kevin C
KC
Toronto Medical Laboratories/Mount Sinai Hospital Department of Microbiology. University of Toronto, Toronto, Ontario, Canada.
McGeer
Allison J
AJ
Duncan
Carla L
CL
Ashi-Sulaiman
Aisha
A
Willey
Barbara M
BM
Sarabia
Alicia
A
McCann
Jacquie
J
Pong-Porter
Sylvia
S
Rzayev
Yana
Y
de Azavedo
Joyce S
JS
Low
Donald E
DE
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D009864:Ontario / Q000453:epidemiology; D010614:Pharynx / Q000382:microbiology; D015995:Prevalence; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000453:epidemiology; D013297:Streptococcus pyogenes / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; D002981:Clindamycin; D004917:Erythromycin; C106791:telithromycin