title: Determinants of treatment strategies and survival in acute myocardial infarction: a population-based study in the Florence district, Italy: results of the acute myocardial infarction Florence registry (AMI-Florence).
abstract: OBJECTIVE
  The Florence Acute Myocardial Infarction Registry is a prospective, observational study aimed at identifying the determinants of use of primary PCI and of prognosis in patients with STE-AMI, in an unselected population-based setting.
  
  
  RESULTS
  Nine hundred and thirty cases of STE-AMI (mean age: 70.5 years) were prospectively recorded. Factors associated with use of revascularization, or influencing survival were identified through multivariate analyses (respectively: logistic and Cox regression). Primary PCI was the preferred reperfusion therapy in the study district, with 50% of STE-AMI cases admitted within 24h, and 58% of those admitted within 12h from symptom onset treated; about 5% of patients undergone fibrinolysis (overall revascularization being 55% and 63%, respectively). Availability of PCI facilities at admission hospital was the strongest independent positive predictor of subsequent primary PCI. Advanced age, comorbidities, Killip class 3, delayed hospitalisation and other factors independently reduced the probability of receiving reperfusion. In the whole series, in-hospital mortality was 6.6% for revascularization and 15.6% for conservative therapy, 6-month mortality was 10.1% and 26.0% respectively. The independent, protective effect of primary PCI persisted at the multivariate analysis, being 44% the reduction in the risk of death at 6 months.
  
  
  CONCLUSIONS
  In this unselected series of patients, primary PCI, routinely performed in high volume centres, achieved good results in terms of survival even outside the setting of a randomised clinical trial. However, the relatively high number of untreated subjects and the tendency to select less severe cases of AMI for reperfusion treatment confirm the need for an accurate reassessment of behavioural patterns in selecting patients for revascularization.
authors.affiliation: Epidemiology Unit, Agenzia Regionale di Sanità della Toscana, via Vittorio Emanuele II 64, 50134 Florence, Italy.
authors.forename: Eva
authors.initials: E
authors.lastname: Buiatti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Barchielli
authors.forename: Niccolò
authors.initials: N
authors.lastname: Marchionni
authors.forename: Daniela
authors.initials: D
authors.lastname: Balzi
authors.forename: Nazario
authors.initials: N
authors.lastname: Carrabba
authors.forename: Serafina
authors.initials: S
authors.lastname: Valente
authors.forename: Iacopo
authors.initials: I
authors.lastname: Olivotto
authors.forename: Cristina
authors.initials: C
authors.lastname: Landini
authors.forename: Maurizio
authors.initials: M
authors.lastname: Filice
authors.forename: Marco
authors.initials: M
authors.lastname: Torri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Regoli
authors.forename: Giovanni M
authors.initials: GM
authors.lastname: Santoro
mesh_terms: D017677:Age Distribution; D000368:Aged; D004630:Emergencies; D004812:Epidemiologic Methods; D005260:Female; D006306:Health Surveys; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality / Q000628:therapy*; D009204:Myocardial Revascularization / Q000379:methods / Q000706:statistics & numerical data; D011379:Prognosis; D013997:Time Factors