title: Hepatic expression of PPARalpha, a molecular target of fibrates, is regulated during inflammation in a gender-specific manner.
abstract: Dyslipidemia, inflammation and gender are major risk factors in cardiovascular disease. Here we show that hepatic expression of Peroxisome proliferator-activated receptor alpha (PPARalpha), a nuclear receptor that regulates lipid metabolism and inflammation, is regulated in a gender-specific manner during lipopolysaccharide (LPS)-induced systemic inflammation. Immediately following LPS-induced systemic inflammation, hepatic PPARalpha mRNA level decreased dramatically in mice. It was restored to baseline within 24 h in females but remained below baseline for >72 h in male mice. In gonadectomized mice of both sexes, PPARalpha mRNA level was restored to baseline within 48 h after the initial decrease.
authors.affiliation: Department of Endocrinology, Singapore General Hospital, Outram Road, Singapore 169608.
authors.forename: E Shyong
authors.initials: ES
authors.lastname: Tai
authors.forename: Azhar
authors.initials: A
authors.lastname: bin Ali
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Lih Ming
authors.initials: LM
authors.lastname: Loh
authors.forename: Chee Eng
authors.initials: CE
authors.lastname: Tan
authors.forename: Leslie
authors.initials: L
authors.lastname: Retnam
authors.forename: Reida Menshawe
authors.initials: RM
authors.lastname: El Oakley
authors.forename: Sai-Kiang
authors.initials: SK
authors.lastname: Lim
mesh_terms: D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007249:Inflammation / Q000503:physiopathology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D012737:Sex Factors; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D017931:DNA Primers; D000960:Hypolipidemic Agents; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors