A nonlinear filter-bank model of the guinea-pig cochlear nerve: rate responses.
The aim of this study is to produce a functional model of the auditory nerve (AN) response of the guinea-pig that reproduces a wide range of important responses to auditory stimulation. The model is intended for use as an input to larger scale models of auditory processing in the brain-stem. A dual-resonance nonlinear filter architecture is used to reproduce the mechanical tuning of the cochlea. Transduction to the activity on the AN is accomplished with a recently proposed model of the inner-hair-cell. Together, these models have been shown to be able to reproduce the response of high-, medium-, and low-spontaneous rate fibers from the guinea-pig AN at high best frequencies (BFs). In this study we generate parameters that allow us to fit the AN model to data from a wide range of BFs. By varying the characteristics of the mechanical filtering as a function of the BF it was possible to reproduce the BF dependence of frequency-threshold tuning curves, AN rate-intensity functions at and away from BF, compression of the basilar membrane at BF as inferred from AN responses, and AN iso-intensity functions. The model is a convenient computational tool for the simulation of the range of nonlinear tuning and rate-responses found across the length of the guinea-pig cochlear nerve.
Sumner
Christian J
CJ
Centre for the Neural Basis of Hearing at Essex, Department of Psychology, University of Essex, Colchester CO4 3SQ, United Kingdom. cjsumner@umich.edu
O'Mard
Lowel P
LP
Lopez-Poveda
Enrique A
EA
Meddis
Ray
R
D000818:Animals; D001309:Auditory Threshold / Q000502:physiology; D001489:Basilar Membrane / Q000502:physiology; D001933:Brain Stem / Q000502:physiology*; D003056:Cochlear Nerve / Q000502:physiology*; D006168:Guinea Pigs; D006199:Hair Cells, Auditory, Inner / Q000502:physiology; D008144:Loudness Perception / Q000502:physiology; D008959:Models, Neurological; D015233:Models, Statistical; D009412:Nerve Fibers / Q000502:physiology; D017711:Nonlinear Dynamics; D010897:Pitch Discrimination / Q000502:physiology*; D013018:Sound Spectrography; D013199:Stapes / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology