Comparison of ability of apoptosis induction by lipopolysaccharide of Porphyromonas gingivalis with Escherichia coli.
We compared effects of Porphyromonas gingivalis LPS with Escherichia coli LPS to the murine peritoneal macrophage. E. coli LPS possessed a threshold dose between 100 micro g and 10 micro g, the higher dose induced apoptosis at the murine peritoneal macrophage while the lower dose did not. The ability of apoptosis induction at the murine peritoneal macrophage of P. gingivalis LPS was weaker than E. coli LPS. P. gingivalis LPS did not induce significant apoptosis in all tested dose. However, the morphology of the peritoneal macrophage treated by P. gingivalis LPS was obviously different from that of the unstimulated cells.
Hirai
Kaname
K
Department of Oral Microbiology, School of Dentistry, Matsumoto Dental University, 1780 Gobara, Hirooka, Shiojiri-shi, Nagano-ken, 399-0781 Japan. kaname8bac@po.mdu.ac.jp
Yoshizawa
H
H
Hasegawa
H
H
Ueda
O
O
Shibata
Y
Y
Fujimura
S
S
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000737:chemistry*; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008262:Macrophage Activation; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D016966:Porphyromonas gingivalis / Q000737:chemistry*
D008070:Lipopolysaccharides