title: The role of somatostatin in vasogenic meningioma associated brain edema.
abstract: Many tumors, including meningiomas, express somatostatin receptors, suggesting the application of somatostatin analogues for therapy and diagnosis. Sixty percent of meningiomas are associated with perilesional edema, whose development seems to be related to the vascular endothelial growth factor, although it requires an efficient pial blood supply. However, in several neoplastic models, other mediators seem to cooperate with vascular endothelial growth factor in regulating angiogenesis. We evaluated somatostatin receptors (sst2) in relation to the possibility that somatostatin analogues may influence vascular endothelial growth factor production with reduction of edema. Of 35 studied meningiomas, 21 presented peritumoural edema. Vascular endothelial growth factor, microvascular density and pial blood supply were significantly related to the edema (P = 0.0001, P = 0.0001, P = 0.0005). Similarly, a relation was found between sst2 and microvascular density (r = 0.58, P < 0.001) and between sst2 and vascular endothelial growth factor expression (P = 0.03). This suggests that somatostatin analogues may be relevant for the treatment of meningiomas.
authors.affiliation: Department of Surgery, University of Pisa, Italy.
authors.forename: Sabina
authors.initials: S
authors.lastname: Pistolesi
authors.forename: Gabriella
authors.initials: G
authors.lastname: Fontanini
authors.forename: Laura
authors.initials: L
authors.lastname: Boldrini
authors.forename: Tiziano
authors.initials: T
authors.lastname: Camacci
authors.forename: Katia
authors.initials: K
authors.lastname: De Ieso
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Lupi
authors.forename: Michele
authors.initials: M
authors.lastname: Caniglia
authors.forename: Giuliano
authors.initials: G
authors.lastname: Mariani
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Boni
authors.forename: Sergio
authors.initials: S
authors.lastname: Suriano
authors.forename: Riccardo
authors.initials: R
authors.lastname: Padolecchia
authors.forename: Raffaele
authors.initials: R
authors.lastname: Pingitore
authors.forename: Giuliano
authors.initials: G
authors.lastname: Parenti
mesh_terms: D000328:Adult; D000368:Aged; D001929:Brain Edema / Q000209:etiology*; D016228:Endothelial Growth Factors / Q000032:analysis; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis; D008222:Lymphokines / Q000032:analysis; D008297:Male; D008577:Meningeal Neoplasms / Q000098:blood supply / Q000150:complications* / Q000188:drug therapy; D008579:Meningioma / Q000098:blood supply / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged; D017481:Receptors, Somatostatin / Q000032:analysis / Q000502:physiology*; D013004:Somatostatin / Q000031:analogs & derivatives / Q000627:therapeutic use; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D017481:Receptors, Somatostatin; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D013004:Somatostatin