Synthesis and biological activity of certain novel derivatives of 1H-pyrrolo[1,2-c][1,3]thiazine.
The reaction of 2-(beta-hydroxyethyl)-pyrrolidine with isothiocyanates gave rise to the formation of thiourea derivatives which cyclised on refluxing in hydrobromic acid to yield N-(3,4,4a,5,6,7-hexahydro-1H-pyrrolo[1,2-c][1,3]thiazin-1-ylidene)-aryl(alkyl)amines. The results of preliminary pharmacological screening are presented.
Jagodziński
Tadeusz S
TS
Institute of Chemistry and Environmental Protection, Department of Organic Chemistry, Technical University of Szczecin, 42 Piastów Av., 71-065 Szczecin, Poland.
Wesołowska
Aneta
A
Jagodzińska
Elzbieta
E
Rump
Sławomir
S
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D003292:Convulsants / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D008401:Gas Chromatography-Mass Spectrometry; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology*
C476283:1H-pyrrolo(1,2-c)(1,3)thiazine; D000927:Anticonvulsants; D002491:Central Nervous System Agents; D003292:Convulsants; D011758:Pyrroles; D013843:Thiazines; D010433:Pentylenetetrazole