Effects of aprotinin on serum interleukin-2 and soluble interleukin-2 receptor during cardiopulmonary bypass.
Interleukin-2 and its receptor are of importance in regulating immunity responses. The changes of interleukin-2 (IL-2) and soluble interleukin-2 receptor (IL-2R) during heart valve (s) replacement operation and effects of aprotinin on them were observed. Twenty patients undergoing heart valve(s) replacement were randomly divided into two groups: control group (n = 10) and aprotinin group (n = 10). In aprotinin group, 1,000,000 KIU aprotinin was given by vein injection and then 2,000,000 KIU was given as a bolus in prime. Blood samples were collected before CPB, right after CPB and on the 1st, 3rd and 7th postoperative day (POD) for serum IL-2 and sIL-2R determination. Results showed that after CPB, IL-2 was reduced and sIL-2R increased. Meanwhile, serum IL-2R was lower in aprotinin group than that of control. It is concluded that the immunity depression after CPB is associated with low level of IL-2 and high level of sIL-2R and aprotinin can ameliorate the situation.
Luo
J
J
Department of Heart Surgery, Institute of Cardiovascular Diseases, Tongji Medical University, Wuhan 430022.
Wang
D
D
Lan
H
H
Sun
Z
Z
D007611:Aprotinin / Q000627:therapeutic use*; D002315:Cardiopulmonary Bypass; D006349:Heart Valve Diseases / Q000097:blood / Q000188:drug therapy / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D015375:Receptors, Interleukin-2 / Q000097:blood*
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D007611:Aprotinin