Chromium(VI) oxide catalyzed oxidation of sulfides to sulfones with periodic acid.
A highly efficient and selective oxidation of sulfides to sulfones with periodic acid catalyzed by CrO(3) is described. A variety of electron-rich and electron-deficient sulfides were oxidized to sulfones with 2 mol % CrO(3) in acetonitrile at room temperature in excellent yields. Sulfides with other readily oxidized functional groups were selectively oxidized to sulfones in high yields with 10 mol % CrO(3) in ethyl acetate/acetonitrile at -35 degrees C.
Xu
Liang
L
Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, USA.
Cheng
Jie
J
Trudell
Mark L
ML