[Relevance of FcgammaRIIIb genotype, IgG G2m(23) factor to the susceptibility of aggressive periodontitis].
OBJECTIVE
To investigate the polymorphism of FcgammaRIIIb genotype, IgG G2m(23) factor and their associations with the susceptibility to aggressive periodontitis.


METHODS
DNA of white blood cells and serum from 21 aggressive periodontitis patients and 26 healthy controls was extracted. Genotype of FcgammaRIIIb and phenotype of G2m(23) factor was determined by allele-specific PCR and dot immunobinding assay respectively.


RESULTS
The frequency of FcgammaRIIIb-NA1/NA1 genotype in aggressive periodontitis patients was significantly higher than in healthy controls (P < 0.05). The ratio of subjects with FcgammaRIIIb-NA1/NA1 genotype and positive G2m(23) factor was higher in aggressive periodontitis patients (11/21) than in health controls (5/26) (P < 0.05). However, no statistical difference in distribution of G2m(23) factor alone was observed between patients and controls.


CONCLUSIONS
This study indicates that FcgammaRIIIb-NA1/NA1 genotype may be a susceptible genotype to aggressive periodontitis in Chinese population. Subjects with FcgammaRIIIb NA1/NA1 genotype and positive G2m(23) factor may be more susceptible to aggressive periodontitis.
Zhang
Hua-xiang
HX
Department of Periodontology, School of Stomatology, Wuhan University, Wuhan 430079, China.
Xie
Hao
H
Ren
Tie-guan
TG
D000328:Adult; D015703:Antigens, CD / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D005260:Female; D058851:GPI-Linked Proteins; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D008297:Male; D010518:Periodontitis / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*
D015703:Antigens, CD; C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; D007129:Immunoglobulin Gm Allotypes; D017452:Receptors, IgG