title: Emergence of nosocomial Pseudomonas aeruginosa colonization/infection in pregnant women with preterm premature rupture of membranes and in their neonates.
abstract: The epidemiology, risk factors, maternal and neonatal outcomes of nosocomial Pseudomonas aeruginosa acquisition in preterm premature rupture of membranes were analysed. Of 63 women receiving antibiotic prophylaxis with co-amoxiclav, 11 acquired P. aeruginosa vaginal carriage with a median delay of 15 days (6-42) i.e. an incidence of 8.94 per 1000 days of expectant management. Five neonates born to 11 positive mothers were colonized or infected, three of whom died of fulminant sepsis. The duration of antibiotic treatment and multiple pregnancy were identified as independent risk factors. The epidemiological investigation revealed a vertical transmission between mothers and neonates, and suggested selective pressure of antibiotic treatment.
authors.affiliation: Unité d'Hygiène Hospitalière, AP-HP, Hôpital Antoine Béclère, Clamart, France.
authors.forename: A
authors.initials: A
authors.lastname: Casetta
authors.forename: F
authors.initials: F
authors.lastname: Audibert
authors.forename: F
authors.initials: F
authors.lastname: Brivet
authors.forename: N
authors.initials: N
authors.lastname: Boutros
authors.forename: C
authors.initials: C
authors.lastname: Boithias
authors.forename: L
authors.initials: L
authors.lastname: Lebrun
mesh_terms: D000328:Adult; D019072:Antibiotic Prophylaxis; D002353:Carrier State / Q000453:epidemiology / Q000517:prevention & control / Q000635:transmission; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control / Q000635:transmission; D003428:Cross Infection / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control / Q000635:transmission; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications*; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D017053:Infection Control; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control / Q000706:statistics & numerical data*; D010298:Parity; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D011256:Pregnancy Outcome; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control / Q000635:transmission; D011550:Pseudomonas aeruginosa / Q000235:genetics; D012307:Risk Factors; D013997:Time Factors; D014621:Vagina / Q000382:microbiology