title: Intracellular release of nitric oxide by NCX 972, an NO-releasing metronidazole, enhances in vitro killing of Entamoeba histolytica.
abstract: The activity of NCX 972, a new molecule obtained by adding a nitric oxide (NO) moiety to metronidazole, was tested against six isolates of Entamoeba histolytica in xenic cultures. NCX 972 released NO into trophozoite cells and enhanced killing of amoebas in a dose- and time-dependent manner compared to metronidazole.
authors.affiliation: Laboratory of Parasitology, Istituto Superiore di Sanità, University of Rome "Roma Tre," Milan, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Sannella
authors.forename: Luigi
authors.initials: L
authors.lastname: Gradoni
authors.forename: Tiziana
authors.initials: T
authors.lastname: Persichini
authors.forename: Ennio
authors.initials: E
authors.lastname: Ongini
authors.forename: Giorgio
authors.initials: G
authors.lastname: Venturini
authors.forename: Marco
authors.initials: M
authors.lastname: Colasanti
mesh_terms: D000818:Animals; D000994:Antitrichomonal Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004748:Entamoeba histolytica / Q000187:drug effects*; D066298:In Vitro Techniques; D008795:Metronidazole / Q000737:chemistry / Q000494:pharmacology*; D009569:Nitric Oxide / Q000737:chemistry*
chemical_list: D000994:Antitrichomonal Agents; D008795:Metronidazole; D009569:Nitric Oxide