title: Cyfra 21-1 in diagnosis of distant metastases of head and neck carcinoma.
abstract: Follow-up examinations of patients might detect local tumor recurrences at a curable stage, which is more difficult for distant metastases (DM). Recently, elevated Cyfra 21-1 serum levels (CySL) could be shown not only to correlate with HNSCC-tumor size but also with development of DM. We focussed on the CySL of 476 HNSCC patients as a first step. At first time diagnosis, besides regular staging procedures, these patients were screened for CySL higher than 3.3 ng/ml. Seventeen out of 476 (3.9%) patients showed DM. Seventeen out of 19 patients (89.5%) presented elevated CySL: A further 830 patients with HNSCC were tested for changes in CySL in the course of disease (cut-off value 3.3 ng/ml). Seventy-one out of 830 patients (8.6%) showed elevated CySL. Tumor growth was found in 50 out of 71 patients (70.4%). In 54% of these patients (27 out of 50) DM were detected. Routine screening for CySL can lead to timely detection of DM in HNSCC, despite its fairly low sensitivity.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Arnold-Heller-Str. 14, D-24105 Kiel, Germany.
authors.forename: Asita
authors.initials: A
authors.lastname: Hoffmann-Fazel
authors.forename: Markus
authors.initials: M
authors.lastname: Hoffmann
authors.forename: Stefan
authors.initials: S
authors.lastname: Gottschlich
authors.forename: Jan D
authors.initials: JD
authors.lastname: Maass
authors.forename: Heinrich
authors.initials: H
authors.lastname: Rudert
authors.forename: Steffen
authors.initials: S
authors.lastname: Maune
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood*; D002283:Carcinoma, Bronchogenic / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002455:Cell Division; D005189:False Positive Reactions; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D053539:Keratin-19; D007633:Keratins; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000175:diagnosis*; D009367:Neoplasm Staging; D015203:Reproducibility of Results
chemical_list: D000951:Antigens, Neoplasm; D053539:Keratin-19; C102012:antigen CYFRA21.1; D007633:Keratins