Tumor necrosis factor-alpha gene polymorphism at position -308 and schizophrenia in the Korean population.
The purpose of the present study was to examine the association between the tumor necrosis factor (TNF)-alpha gene (A) polymorphism and schizophrenia in a Korean sample of schizophrenic patients and control subjects. Genotyping for the TNFA polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions of the TNFA polymorphism between schizophrenic patients and controls were not significantly different. In the light of these results, the TNFA polymorphism seems not to confer susceptibility to the pathogenesis of schizophrenia, at least in the Korean population.
Pae
Chi-Un
CU
Department of Psychiatry, Kangnam St Mary's Hospital, Catholic University of Korea College of Medicine, Seocho-Gu, Seoul.
Chae
Jeong-Ho
JH
Bahk
Won-Myong
WM
Han
Hoon
H
Jun
Tae-Youn
TY
Kim
Kwang-Soo
KS
Kwon
Yong-Sil
YS
Serretti
Alessandro
A
D000328:Adult; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012559:Schizophrenia / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha