title: [Relevance of FcgammaRIIIb genotype, IgG G2m(23) factor to the susceptibility of aggressive periodontitis].
abstract: OBJECTIVE
  To investigate the polymorphism of FcgammaRIIIb genotype, IgG G2m(23) factor and their associations with the susceptibility to aggressive periodontitis.
  
  
  METHODS
  DNA of white blood cells and serum from 21 aggressive periodontitis patients and 26 healthy controls was extracted. Genotype of FcgammaRIIIb and phenotype of G2m(23) factor was determined by allele-specific PCR and dot immunobinding assay respectively.
  
  
  RESULTS
  The frequency of FcgammaRIIIb-NA1/NA1 genotype in aggressive periodontitis patients was significantly higher than in healthy controls (P < 0.05). The ratio of subjects with FcgammaRIIIb-NA1/NA1 genotype and positive G2m(23) factor was higher in aggressive periodontitis patients (11/21) than in health controls (5/26) (P < 0.05). However, no statistical difference in distribution of G2m(23) factor alone was observed between patients and controls.
  
  
  CONCLUSIONS
  This study indicates that FcgammaRIIIb-NA1/NA1 genotype may be a susceptible genotype to aggressive periodontitis in Chinese population. Subjects with FcgammaRIIIb NA1/NA1 genotype and positive G2m(23) factor may be more susceptible to aggressive periodontitis.
authors.affiliation: Department of Periodontology, School of Stomatology, Wuhan University, Wuhan 430079, China.
authors.forename: Hua-xiang
authors.initials: HX
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Xie
authors.forename: Tie-guan
authors.initials: TG
authors.lastname: Ren
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D005260:Female; D058851:GPI-Linked Proteins; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D008297:Male; D010518:Periodontitis / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*
chemical_list: D015703:Antigens, CD; C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; D007129:Immunoglobulin Gm Allotypes; D017452:Receptors, IgG