title: PARP-1, a determinant of cell survival in response to DNA damage.
abstract: Poly(ADP-ribose) polymerase-1 (PARP-1) plays a primary role in the process of poly(ADP-ribosyl)ation. This posttranslational modification of nuclear proteins is activated in response to DNA damage. Having been studied for more than 30 years, PARP-1 is now known to be implicated in several crucial cellular processes: DNA replication, transcription, DNA repair, apoptosis, and genome stability. In this review, we focus on recent findings suggesting that PARP-1 participates in DNA damage signaling in cell death. Of clinical relevance is its role in cancer therapy, irradiation, and chemotherapy, all of which may cause DNA damage and overactivate PARP-1, resulting in inflammation caused by necrosis. Therefore, we will discuss how inhibition of PARP-1 may enhance the efficiency of cancer therapy.
authors.affiliation: Health and Environment Unit, Faculty of Medicine, Laval University Medical Research Center, 2705 Boulevard Laurier, Ste-Foy, Québec, Canada G1V 4G2.
authors.forename: Véronique J
authors.initials: VJ
authors.lastname: Bouchard
authors.forename: Michèle
authors.initials: M
authors.lastname: Rouleau
authors.forename: Guy G
authors.initials: GG
authors.lastname: Poirier
mesh_terms: D002470:Cell Survival; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; D011506:Proteins / Q000502:physiology*
chemical_list: D011506:Proteins; C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases