Two case studies of hypothermia induced by an increased dosage of zotepine in a combination therapy.
The purpose of the present paper was to remind physicians that hypothermia is a possible side-effect of combining zotepine, valproate,and benzodiazepine. Two cases of hypothermia occurred after combining the use of zotepine, valproate, and benzodiazepine. The valproate was under therapeutic blood level when zotepine dosage was raised to 200 mg/day, and hypothermia occurred. The dosage of zotepine might constitute a positive correlation with hypothermia. The combination of zotepine, valproate or benzodiazepine may cause hypothermia as a side-effect.
Chen
Kao Ching
KC
Department of Psychiatry, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan. andchenni@yahoo.com.tw
Yang
Yen Kuang
YK
Chen
Po See
PS
Yeh
Tzung Lieh
TL
Yang
Ming Jen
MJ
D000328:Adult; D014151:Anti-Anxiety Agents / Q000009:adverse effects; D000927:Anticonvulsants / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy; D003975:Diazepam / Q000009:adverse effects; D003988:Dibenzothiepins / Q000008:administration & dosage* / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D007035:Hypothermia / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy; D014635:Valproic Acid / Q000009:adverse effects
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D014150:Antipsychotic Agents; D003988:Dibenzothiepins; D014635:Valproic Acid; D003975:Diazepam; C022172:zotepine