title: Phase shifts and Per gene expression in mouse suprachiasmatic nucleus.
abstract: In mammals, circadian rhythms controlled by the suprachiasmatic nuclei are entrained by photic stimuli. To investigate the molecular mechanism of photic entrainment, we examined light-induced behavioral phase delays and associated changes in mPer1 and mPer2 gene expression in the suprachiasmatic nuclei of two mouse lines artificially selected for nest-building behavior. Big nest-builders show larger phase delays than small nest-builders. Light-induced mPer1 and mPer2 expression was examined in individual mice previously tested for phase shifting at circadian time 16. Light-induced mPer2 expression was significantly higher in big compared to small nest-builders. No difference was found between lines in light-induced mPer1 expression. The results suggest a more important role for mPer2 than for mPer1 gene expression in behavioral phase delays.
authors.affiliation: Department of Psychology, Columbia University, New York, NY 10027, USA.
authors.forename: Lily
authors.initials: L
authors.lastname: Yan
authors.forename: Kelly J
authors.initials: KJ
authors.lastname: Hochstetler
authors.forename: Rae
authors.initials: R
authors.lastname: Silver
authors.forename: Abel
authors.initials: A
authors.lastname: Bult-Ito
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins; D005786:Gene Expression Regulation / Q000502:physiology*; D008297:Male; D051379:Mice; D009687:Nuclear Proteins / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics; D056950:Period Circadian Proteins; D010775:Photic Stimulation / Q000379:methods; D013493:Suprachiasmatic Nucleus / Q000737:chemistry / Q000378:metabolism*; D014157:Transcription Factors
chemical_list: D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; C539023:Per1 protein, mouse; C513312:Per2 protein, mouse; D056950:Period Circadian Proteins; D014157:Transcription Factors