Effect of Bak Foong pills on enhancing dopamine release from the amygdala of female rats.
To investigate whether Bak Foong Pills (BFP), a well-known gynaecological tonic, has a direct effect on the central nervous system, we employed the in vivo electrochemical detection technique, fast cyclic voltammetry (FCV), to measure the dopamine release from the mesolimbic structure-amygdala of both male and female rats. The results showed that intracerebroventricular BFP (0.75, 1.5 microg) treatment promoted dopamine release from the amygdala in both female and ovariectomized female rats. The BFP-induced response appeared within 5 min after addition of BFP and lasted for at least 40 min. However, no effect of BFP was observed in male rats for an observed period of up to 60 min. The results suggest that BFP may have gender-specific beneficial effect on dopaminergic functions of the amygdala.
Liu
Bin
B
Department of Physiology, College of Medicine, Qingdao University, PR China.
Dong
Xiao Li
XL
Xie
Jun Xia
JX
Gou
Yu Lin
YL
Rowlands
Dewi Kenneth
DK
Chan
Hsiao Chang
HC
D000679:Amygdala / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004558:Electric Stimulation / Q000379:methods; D005260:Female; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics
C508116:Bak Foong Pills; D004365:Drugs, Chinese Herbal; D004298:Dopamine