title: [Long term observation in effects of potassium and calcium supplementation on arterial blood pressure and sodium metabolism in adolescents with higher blood pressure].
abstract: OBJECTIVE
  To investigate the effects of potassium and calcium supplementation in table salt on reduction of arterial blood pressure and sodium metabolism in adolescents with higher blood pressure.
  
  
  METHODS
  A single blind placebo-controlled trial was carried out for two years in 220 adolescents with higher blood pressure, aged 18 - 22 years, who were randomly divided into supplementary group (n = 110) and control group (n = 110). Each of the subjects in the supplementary group and their family members was given 10 mmol of potassium and 10 mmol of calcium mixed in their table salt daily for 24 months.
  
  
  RESULTS
  Night urinary sodium and potassium excretion increased (urinary Na(+), P < 0.05; urinary K(+), P < 0.01) and blood pressure lowered by 5.3 mm Hg/1.8 mm Hg in average from the baseline in the supplementary group two years after potassium and calcium supplementation, as compared with that in the control group increased by (1.3/1.7) mm Hg.
  
  
  CONCLUSIONS
  Adequate supplement of potassium and calcium in daily table salt intake was an effective way to prevent form hypertension and could promote their urinary sodium excretion and reduction of arterial blood pressure in adolescents with higher blood pressure.
authors.affiliation: The First Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Mu
authors.forename: Zhi-quan
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Yi-mu
authors.initials: YM
authors.lastname: Liang
authors.forename: Dan-jun
authors.initials: DJ
authors.lastname: Zhy
authors.forename: Yong-xing
authors.initials: YX
authors.lastname: Wang
authors.forename: Bao-lin
authors.initials: BL
authors.lastname: Gao
authors.forename: Xiao-ling
authors.initials: XL
authors.lastname: Zhang
authors.forename: Hua-chun
authors.initials: HC
authors.lastname: Ji
authors.forename: Xiang-lin
authors.initials: XL
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D015924:Blood Pressure Monitors; D002136:Calcium, Dietary / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000178:diet therapy / Q000517:prevention & control*; D008297:Male; D009318:Natriuresis; D017419:Potassium, Dietary / Q000008:administration & dosage*; D016037:Single-Blind Method; D012964:Sodium / Q000378:metabolism*; D012982:Sodium, Dietary / Q000008:administration & dosage
chemical_list: D002136:Calcium, Dietary; D017419:Potassium, Dietary; D012982:Sodium, Dietary; D012964:Sodium