The establishment and maintenance of lymphocyte identity through gene silencing.
Cell identity is determined by selective gene activation and by the maintenance of other regulated genes in a silent state. Although activation mechanisms have been dissected in considerable depth, great strides towards an understanding of the molecular control of gene silencing have been made only recently. Molecular hallmarks of silent chromatin and proteins involved in its assembly and maintenance have been identified through genetic, cytological and biochemical studies in a variety of organisms. Immunologists are now beginning to use this knowledge to elucidate mechanisms underlying cell fate decisions and key developmental steps. This review surveys the current knowledge of gene silencing, with an emphasis on studies in lymphocytes that are advancing our general understanding of silencing mechanisms during development.
Smale
Stephen T
ST
Howard Hughes Medical Institute and Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California 90095-1662, USA. smale@mednet.ucla.edu
D000818:Animals; D015704:CD4 Antigens / Q000235:genetics; D002843:Chromatin / Q000502:physiology; D018899:CpG Islands; D019175:DNA Methylation; D005786:Gene Expression Regulation; D020868:Gene Silencing; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D015533:Transcriptional Activation
D015704:CD4 Antigens; D002843:Chromatin