The 14-3-3 proteins: gene, gene expression, and function.
14-3-3 proteins were discovered by Moore and Perez in the soluble extract of bovine brain. These proteins are highly abundant in the brain. In this review 14-3-3 cDNA cloning, nucleotide sequence of 14-3-3 cDNA, the structure of 14-3-3 gene and 14-3-3 gene expression, in situ hybridization of 14-3-3 mRNA in the brain, the function and regulation of 14-3-3 protein, the binding of 14-3-3 protein to other proteins, the effects of 14-3-3 protein on the binding of a protein to other proteins, and the effect on protein kinase, etc., are concisely described. From the recent rapid development of proteom technology, markedly more target proteins of 14-3-3 protein should be discovered.
Takahashi
Yasuo
Y
Department of Molecular Neuropathology, Brain Research Institute, Niigata University, Niigata City 951-8585, Japan.
D048948:14-3-3 Proteins; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary; D015870:Gene Expression; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011485:Protein Binding; D012333:RNA, Messenger / Q000235:genetics; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*
D048948:14-3-3 Proteins; D018076:DNA, Complementary; D012333:RNA, Messenger; D014446:Tyrosine 3-Monooxygenase