International expert panel on the use of primary (preoperative) systemic treatment of operable breast cancer: review and recommendations.
Primary systemic therapy (PST) represents the standard of care in patients with locally advanced breast cancer. In addition, there is increasing information on PST in operable breast disease that supports the use of PST in routine practice. However, current regimens and techniques vary. To address this concern, a group of representatives from breast cancer clinical research groups in France, Germany, Italy, the United Kingdom, and the United States reviewed all available data on prospective randomized trials in this setting. Recommendations are made regarding terminology, indications, regimen, diagnosis before treatment, monitoring of efficacy, tumor localization, surgery, pathologic evaluation, and postoperative treatment.
Kaufmann
Manfred
M
Department of Gynecology and Obstetrics, Goethe University, Frankfurt am Main, Germany. M.Kaufmann@em.uni-frankfurt.de
von Minckwitz
Gunter
G
Smith
Roy
R
Valero
Vicente
V
Gianni
Luca
L
Eiermann
Wolfgang
W
Howell
Anthony
A
Costa
Serban Dan
SD
Beuzeboc
Philippe
P
Untch
Michael
M
Blohmer
Jens-Uwe
JU
Sinn
Hans-Peter
HP
Sittek
Rolf
R
Souchon
Rainer
R
Tulusan
Augustinos H
AH
Volm
Tanja
T
Senn
Hans-Jörg
HJ
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D007391:International Cooperation; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic