[Recurrence of gastropathies caused by intake of nonsteroidal anti-inflammatory drugs].
OBJECTIVE
To estimate frequency of ulcers and erosions associated with administration of nonsteroid anti-inflammatory drugs (NSAID) in patients with rheumatic diseases.


METHODS
The analysis of the clinic endoscopic data base allowed division of the patients into three groups: group 1--207 patients examined with esophagogastroduodenoscopy (EGDS) which detected ulcers or multiple erosions of the stomach and/or duodenum in the course of treatment with NSAID; group 2--157 patients with a few erosions of the stomach or duodenum; group 3--404 controls who had neither erosions nor ulcers in the course of NSAID treatment.


RESULTS
Frequency of detection of ulcers and multiple erosions for groups 1, 2 and 3 was 40.1, 12.1 and 7.4%, respectively. Recurrences did not correlate with age, sex, dose of glucoorticosteroids, NSAID dose, cytostatics, preventive use of antiulcer drugs. Few gastric erosions were detected more frequently in patients of group 2 than group 3 (22.9 and 9.2%, respectively, p < 0.05).


CONCLUSIONS
NSAID-induced ulcers in patients with rheumatic diseases are recurrent. Preventive intake of H2-blockers did not lower the risk of ulcer recurrence. Erosions tend to recurrence but their presence do not raise the risk of ulcer development.
Karameev
A E
AE
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D003627:Data Interpretation, Statistical; D004381:Duodenal Ulcer / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D004384:Duodenoscopy; D005260:Female; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012216:Rheumatic Diseases / Q000188:drug therapy; D012307:Risk Factors; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents