title: Synergistic in vitro interactions between alpha interferon and ribavirin against bovine viral diarrhea virus and yellow fever virus as surrogate models of hepatitis C virus replication.
abstract: Monotherapy of hepatitis C virus infection with either alpha interferon or ribavirin alone is rather ineffective, while the use of the two antivirals together is much more efficacious. In vitro drug-drug combination analysis utilizing related members of the family Flaviviridae, bovine viral diarrhea virus and yellow fever virus, revealed significant direct synergistic interactions between these drugs' antiviral activities that might explain this clinical observation.
authors.affiliation: Infectious Disease Research Department, Southern Research Institute, Frederick, Maryland 21701, USA. Buckwold@sri.org
authors.forename: Victor E
authors.initials: VE
authors.lastname: Buckwold
authors.forename: Jiayi
authors.initials: J
authors.lastname: Wei
authors.forename: Michelle
authors.initials: M
authors.lastname: Wenzel-Mathers
authors.forename: Julie
authors.initials: J
authors.lastname: Russell
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002417:Cattle; D002460:Cell Line; D001908:Diarrhea Viruses, Bovine Viral / Q000187:drug effects* / Q000254:growth & development; D004357:Drug Synergism; D016174:Hepacivirus / Q000254:growth & development*; D066298:In Vitro Techniques; D016898:Interferon-alpha / Q000494:pharmacology*; D012254:Ribavirin / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects; D015005:Yellow fever virus / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D012254:Ribavirin