[Triggering cell mitosis in higher eukaryotes].
Dramatic changes of cell organisation occur at onset of mitosis. Genetic analysis of fission yeast and physiological studies of vertebrate and invertebrate oocytes showed that activation of cyclin B-cdc2 kinase triggers mitosis. Nevertheless, upstream mechanisms responsible for this activation remain largely unknown in somatic cells of higher eukaryotes. This review discusses possible pathways and mechanisms involved in triggering onset of mitosis in such cells, including inhibitory checkpoint mechanisms that detect defects in structural organisation of the cell.
Dorée
Marcel
M
CRBM, UPR 1086-Cnrs, 1919, route de Mende, 34290 Montpellier, France. doree@crbm.cnrs-mop.fr
D000818:Animals; D042846:CDC2-CDC28 Kinases; D002875:Chromosomes; D019926:Cyclin B / Q000494:pharmacology*; D018844:Cyclin-Dependent Kinases / Q000494:pharmacology*; D004261:DNA Replication; D005057:Eukaryotic Cells / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007448:Invertebrates; D008938:Mitosis; D011494:Protein Kinases / Q000096:biosynthesis / Q000494:pharmacology; D014714:Vertebrates; D015003:Yeasts
D019926:Cyclin B; D011494:Protein Kinases; D042846:CDC2-CDC28 Kinases; D018844:Cyclin-Dependent Kinases