Activity of clarithromycin alone and in combination in a murine model of Mycobacterium kansasii infection.
Activities of clarithromycin alone and in combination with rifampicin, gatifloxacin or linezolid were evaluated against Mycobacterium kansasii in a murine infection model. Clarithromycin was the most active single agent. Rifampicin and gatifloxacin had similar activities, but were less active than clarithromycin. Clarithromycin in combination with rifampicin was the most active combination therapy.
Cynamon
Michael H
MH
Department of Medicine, Veterans Affairs Medical Center, 800 Irving Avenue, Syracuse, NY 13210, USA. Michael.Cynamon@med.VA.gov
Elliott
Shannon A
SA
DeStefano
Michelle S
MS
Yeo
Anthony E T
AE
D000818:Animals; D017291:Clarithromycin / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy*; D019909:Mycobacterium kansasii / Q000187:drug effects*
D017291:Clarithromycin