Oxygen delivery in irradiated normal tissue.
Ionizing radiation exposure significantly alters the structure and function of microvascular networks, which regulate delivery of oxygen to tissue. In this study we use a hamster cremaster muscle model to study changes in microvascular network parameters and use a mathematical model to study the effects of these observed structural and microhemodynamic changes in microvascular networks on oxygen delivery to the tissue. Our experimental observations indicate that in microvascular networks while some parameters are significantly affected by irradiation (e.g. RBC transit time), others remain at the control level (e.g. RBC path length) up to 180 days post-irradiation. The results from our mathematical model indicate that tissue oxygenation patterns are significantly different in irradiated normal tissue as compared to age-matched controls and the differences are apparent as early as 3 days post irradiation. However, oxygen delivery to irradiated tissue was not found to be significantly different from age matched controls at any time between 7 days to 6 months post-irradiation. These findings indicate that microvascular late effects in irradiated normal tissue may be due to factors other than compromised tissue oxygenation.
Kiani
Mohammad F
MF
School of Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN 38163, USA. mkiani@utmem.edu
Ansari
Ramin
R
Gaber
M Waleed
MW
D000009:Abdominal Muscles / Q000098:blood supply / Q000528:radiation effects; D000818:Animals; D001682:Biological Availability; D001783:Blood Flow Velocity / Q000528:radiation effects; D006224:Cricetinae; D004912:Erythrocytes / Q000502:physiology / Q000528:radiation effects; D008297:Male; D008647:Mesocricetus; D008833:Microcirculation / Q000528:radiation effects; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000528:radiation effects*; D010100:Oxygen / Q000097:blood*
D010100:Oxygen