title: Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients.
abstract: Platelets, like neurons, contain 120- to 130- and 110-kd amyloid precursor proteins (APPs). Their ratio is reduced in AD, further reductions correlating with reduced Mini-Mental Status Examination scores [r(11) = 0.69, p < 0.05]. As statins alter APP processing, platelet APPs were analyzed in patients with AD given anticholesterol drugs for 6 weeks. APP ratios increased [t(37) = -3.888, p = 0.0004], proportionally with reduced cholesterol [r(36) = -0.45, p = 0.005]. Longer trials may reveal slowed cognitive loss, validating this index.
authors.affiliation: Department of Neurology, University of Texas Southwestern Medical Center at Dallas, TX 75390-9036, USA. Fred.Baskin@UTSouthwestern.edu
authors.forename: F
authors.initials: F
authors.lastname: Baskin
authors.forename: R N
authors.initials: RN
authors.lastname: Rosenberg
authors.forename: X
authors.initials: X
authors.lastname: Fang
authors.forename: L S
authors.initials: LS
authors.lastname: Hynan
authors.forename: C B
authors.initials: CB
authors.lastname: Moore
authors.forename: M
authors.initials: M
authors.lastname: Weiner
authors.forename: G L
authors.initials: GL
authors.lastname: Vega
mesh_terms: D000544:Alzheimer Disease / Q000097:blood* / Q000188:drug therapy; D016229:Amyloid beta-Peptides / Q000097:blood*; D016564:Amyloid beta-Protein Precursor / Q000097:blood*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D008148:Lovastatin / Q000494:pharmacology* / Q000627:therapeutic use; D009525:Niacin / Q000494:pharmacology / Q000627:therapeutic use; D017035:Pravastatin / Q000494:pharmacology* / Q000627:therapeutic use; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D019821:Simvastatin / Q000494:pharmacology* / Q000627:therapeutic use; D016037:Single-Blind Method
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D009525:Niacin; D002784:Cholesterol; D008148:Lovastatin; D019821:Simvastatin; D017035:Pravastatin