Identification of RIP140 as a nuclear receptor cofactor with a role in female reproduction.
Nuclear receptors function as ligand-dependent transcription factors by recruiting cofactors that remodel chromatin and recruit the transcription machinery. RIP140 (receptor interacting protein with a molecular weight of 140 kDa) is a widely expressed corepressor that has the potential to inhibit the transcriptional activity of most, if not all nuclear receptors. Mice devoid of RIP140 indicate that it plays a crucial role in female fertility and in adipose biology. It is essential in the ovary for ovulation, specifically oocyte release but not luteinisation of mature follicles. Our goal is to identify the key nuclear receptor(s) and their target genes responsible for ovulation.
Parker
Malcolm
M
Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College, Du Cane Rd, London W12 ONN, UK. m.parker@imperial.ac.uk
Leonardsson
Göran
G
White
Roger
R
Steel
Jennifer
J
Milligan
Stuart
S
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D000858:Anovulation / Q000235:genetics; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000235:genetics; D008024:Ligands; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000078723:Nuclear Receptor Interacting Protein 1; D010053:Ovary / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D012098:Reproduction / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D048868:Adaptor Proteins, Signal Transducing; D002843:Chromatin; D008024:Ligands; C000627127:NRIP1 protein, human; D009687:Nuclear Proteins; D000078723:Nuclear Receptor Interacting Protein 1; D018160:Receptors, Cytoplasmic and Nuclear; D012097:Repressor Proteins; D014157:Transcription Factors