title: Regulated recruitment and cooperativity in the design of biological regulatory systems.
abstract: What distinguishes a man from a mouse is not so much different proteins, but rather the appearance of common proteins (etc.) at different times and positions in the developing organisms. Thus specific genes are transcribed or repressed, proteins degraded or stabilized, RNA transcripts spliced one way or another, and so on. These are examples of 'regulatory' decisions. A rather simple mechanism - called regulated recruitment - lies at the heart of many of these regulatory decisions.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 595, New York, NY 10021, USA. m-ptashne@ski.mskcc.org
authors.forename: Mark
authors.initials: M
authors.lastname: Ptashne
mesh_terms: D020536:Enzyme Activators / Q000378:metabolism; D004795:Enzyme Stability; D025461:Feedback, Physiological / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D046911:Macromolecular Substances; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D013045:Species Specificity; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D020536:Enzyme Activators; D046911:Macromolecular Substances; D011506:Proteins