title: Effects of recombinant human leptin treatment as an adjunct of moderate energy restriction on body weight, resting energy expenditure and energy intake in obese humans.
abstract: We explored the effects of recombinant human leptin (rL) as an adjunct of mild energy restriction (2092 kJ/day less than needed) in the treatment of obese humans as part of a larger multicentre trial. In a double blind, randomised, placebo (P)-controlled design, the effects of 10 mg of rL once daily vs twice daily (rL OD/BID, by s.c. injection) upon body weight, resting energy expenditure (REE) and energy intake were compared. The study groups comprised 9 (P), 15 (rL OD) and 6 (rL BID) healthy subjects (body mass index 27.5-35 kg/m2). We observed in both groups treated with rL a decline of body weight. [2.8+/-1.1 kg (P), 5.2+/-0.9 kg (rL OD), 7.9+/-1.4 kg (rL BID), p < 0.035]. No significant effects of rL treatment upon energy intake or REE were observed. However, rL tended to reduce the decline of energy expenditure associated with energy restriction, whereas the tendency of energy intake to increase back to baseline levels in placebo-treated subjects was largely prevented in subjects treated with rL. Thus, rL appears to enhance the loss of body weight in obese humans in a dose-dependent fashion if prescribed as an adjunct of energy restriction. This effect might be mediated by rL ability to counteract the behavioural and metabolic adaptations that accompany weight loss attempts.
authors.affiliation: Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands. a.j.fogteloo@lumc.nl
authors.forename: A J
authors.initials: AJ
authors.lastname: Fogteloo
authors.forename: H
authors.initials: H
authors.lastname: Pijl
authors.forename: M
authors.initials: M
authors.lastname: Frölich
authors.forename: M
authors.initials: M
authors.lastname: McCamish
authors.forename: A E
authors.initials: AE
authors.lastname: Meinders
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects; D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects*; D002153:Calorimetry, Indirect; D004038:Diet, Reducing; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D002149:Energy Intake / Q000187:drug effects*; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D020738:Leptin / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D020738:Leptin; D011994:Recombinant Proteins