New strategies for craniofacial repair and replacement: a brief review.
Craniofacial anomalies can severely affect the appearance, function, and psychosocial well being of patients; thus, tissue engineers are developing new techniques to functionally and aesthetically rebuild craniofacial structures. In the past decade, there have been tremendous advances in the field of tissue engineering that will substantially alter how surgeons approach craniofacial reconstruction. In this brief review, we highlight some of the preclinical recombinant protein, gene transfer, and cell-based strategies currently being developed to augment endogenous tissue repair or create structures for replacement. In addition, we discuss the importance of studying endogenous models of tissue induction and present some of the current in vitro and in vivo approaches to growing complex tissues/organs for craniofacial reconstruction.
Fong
Kenton D
KD
Department of Surgery, Stanford University School of Medicine, 257 Campus Drive, Stanford, CA 94305-5148, USA.
Nacamuli
Randall P
RP
Song
HanJoon M
HM
Warren
Stephen M
SM
Lorenz
H Peter
HP
Longaker
Michael T
MT
D000818:Animals; D017690:Cell Transplantation; D002478:Cells, Cultured / Q000637:transplantation; D019465:Craniofacial Abnormalities / Q000628:therapy*; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors / Q000627:therapeutic use; D006801:Humans; D008954:Models, Biological; D019736:Prostheses and Implants; D011994:Recombinant Proteins / Q000627:therapeutic use; D019651:Plastic Surgery Procedures / Q000379:methods; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods
D011994:Recombinant Proteins