Evidence of an association between Chlamydia pneumoniae and cerebrovascular accidents.
The authors report results of a retrospective pilot study showing a strong association between patients with stroke/TIA and the presence of circulating IgG and IgA antibodies to Chlamydia pneumoniae. These results support the hypothesis that chronic active or persistent infection may play a role in the mechanism of thrombosis. The risk for stroke associated with Chlamydial circulating antibodies appeared to be independent of other risk factors such as diabetes and hypercholesterolemia.
Bucurescu
G
G
Neurology Service, Veterans Affairs Medical Center, Philadelphia, PA 19104, USA. gabriel.bucurescu@med.va.gov
Stieritz
D D
DD
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D023521:Chlamydophila Infections / Q000150:complications*; D016993:Chlamydophila pneumoniae / Q000276:immunology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000378:metabolism; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010865:Pilot Projects; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000276:immunology / Q000382:microbiology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G