title: Massadine, a novel geranylgeranyltransferase type I inhibitor from the marine sponge Stylissa aff. massa.
abstract: Massadine, a highly oxygenated alkaloid, was isolated from the marine sponge Stylissa aff. massa as an inhibitor of geranylgeranyltransferase type I (GGTase I). The structure of massadine has been deduced from spectral data. Massidine inhibited GGTase I from Candida albicans with an IC(50) value of 3.9 microM. [structure: see text]
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nishimura
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Shibazaki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Furihata
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fusetani
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D002176:Candida albicans / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D017368:Protein Prenylation; D011758:Pyrroles / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D000470:Alkaloids; D004791:Enzyme Inhibitors; D011758:Pyrroles; C478874:massadine; D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I