title: Dynamic contrast enhancement of paragangliomas of the head and neck: evaluation with time-resolved 2D MR projection angiography.
abstract: Our objective was to evaluate tumor hemodynamics of paragangliomas of the head and neck. A 2D magnetic resonance projection angiography (MRPA) protocol was developed. Six patients with histologically proven paragangliomas were included in the study. The sequence protocol and data post-processing procedure were optimized in view of a high temporal resolution and maximum contrast-to-noise ratio. Image-time series of two freely orientated slabs could be obtained. Correlation analysis was performed to generate selective arterial and venous weighted angiographic images. Glomus tumors showed a rapid and intense homogeneous enhancement following the intravenous administration of contrast material. The smallest tumors investigated measured 10 mm and could be visualized clearly. Time-resolved analysis of the tumor enhancement revealed an early bolus arrival within the vascular bed of the tumor and prolonged incomplete washout indicating blood pooling. The dynamic contrast enhancement of glomus tumors can be evaluated non-invasively with MRPA providing a high temporal resolution and high image quality. The characteristic contrast enhancement of glomus tumors can be helpful in the diagnostic workup of lesions that may mimic glomus tumors.
authors.affiliation: Department of Neuroradiology, University of Freiburg, 79106 Freiburg, Germany. sarnold@uhbs.ch
authors.forename: Sebastian M
authors.initials: SM
authors.lastname: Arnold
authors.forename: Ralph
authors.initials: R
authors.lastname: Strecker
authors.forename: Klaus
authors.initials: K
authors.lastname: Scheffler
authors.forename: Joachim
authors.initials: J
authors.lastname: Spreer
authors.forename: Jörg
authors.initials: J
authors.lastname: Schipper
authors.forename: Hartmut P H
authors.initials: HP
authors.lastname: Neumann
authors.forename: Joachim
authors.initials: J
authors.lastname: Klisch
mesh_terms: D002345:Carotid Body Tumor / Q000175:diagnosis*; D003287:Contrast Media; D005682:Gadolinium; D005925:Glomus Jugulare Tumor / Q000175:diagnosis*; D005918:Glomus Tumor / Q000175:diagnosis*; D006258:Head and Neck Neoplasms / Q000175:diagnosis*; D006571:Heterocyclic Compounds; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D009942:Organometallic Compounds
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium