Photodynamic therapy of corneal neovascularization with verteporfin.
OBJECTIVE
To describe the effect of photodynamic therapy (PDT) using verteporfin (Visudyne) on corneal neovascularization (CNV) in two patients.


METHODS
Two patients with corneal neovascularization were treated with a nonthermal laser light at 689 nm delivered 15 min after an intravenous infusion of verteporfin. Postoperative outcome of neovascularization was followed clinically (inflammation, intraocular pressure, and visual acuity) and photographically [color photographs and corneal fluorescein and indocyanine green (ICG) angiography] for a minimum of 6 months.


RESULTS
Successful photothrombosis of corneal neovascularization was obtained immediately after treatment in the two patients, and regression was verified by corneal fluorescein and ICG angiography. In one case, partial vessel recanalization was observed after 1 month, and treatment was repeated, with complete regression of new vessels. No relevant side effects were observed in our cases.


CONCLUSIONS
PDT with verteporfin is an effective and safe procedure indicated for patients with corneal neovascularization; however, multiple sessions may be required.
Fossarello
Maurizio
M
Department of Surgical Sciences, Eye Clinic, University of Cagliari, Italy. mfossarello@libero.it
Peiretti
Enrico
E
Zucca
Ignazio
I
Serra
Antonina
A
D000368:Aged; D003316:Corneal Diseases / Q000150:complications / Q000209:etiology / Q000378:metabolism; D016510:Corneal Neovascularization / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D016849:Keratitis, Herpetic / Q000150:complications; D050356:Lipid Metabolism; D008297:Male; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011166:Porphyrins / Q000627:therapeutic use*; D019233:Retreatment; D016896:Treatment Outcome; D000077362:Verteporfin
D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin