title: Synthesis and DNA binding properties of alkyl-linked bis(benzimidazole) compounds.
abstract: We have synthesized novel alkyl-linked bis(benzimidazole) compounds and studied their DNA binding properties by spectroscopic (absorption, CD, flow dichroism and fluorescence) and viscosity measurements. The results indicate that bis(benzimidazole) compounds interact with DNA both by intercalation and by groove binding.
authors.affiliation: Department of Chemistry, Faculty of Science, Yamaguchi University, Yamaguchi 753-8512, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: H
authors.initials: H
authors.lastname: Fujii
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Tani
mesh_terms: D000478:Alkylation; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D001562:Benzimidazoles / Q000737:chemistry*; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D010419:Pentamidine / Q000737:chemistry; D013053:Spectrophotometry; D014783:Viscosity
chemical_list: D000890:Anti-Infective Agents; D001562:Benzimidazoles; D007364:Intercalating Agents; C009712:bis-benzimidazole; D010419:Pentamidine; D004247:DNA