Preparation and evaluation of sustained release microspheres of potassium chloride prepared with ethylcellulose.
The water-insoluble polymer ethylcellulose is used as a retardant to prepare the sustained release of potassium chloride microspheres by drying in a liquid process. The effect of sustained release of potassium from ethylcellulose microspheres was evaluated by the in vitro dissolution test, and was compared to a commercial product (Slow-K). The results showed that ethylcellulose microspheres loaded with potassium chloride could be easily prepared and satisfactory results could be obtained considering size distribution and shapes of microspheres by incorporating aluminum stearate. The encapsulation efficiency and loading capacity were about 84-93 and 36%, respectively. However, the potassium/ethylcellulose 2/2 (30-45 mesh) microspheres showed the similar sustained release effect of commercial product.
Wu
Pao-Chu
PC
School of Pharmacy, Kaohsiung Medical University, 100 Shih-Chen 1st Road, Kaohsiung 807, Taiwan, ROC.
Huang
Yaw-Bin
YB
Chang
Jui-I
JI
Tsai
Ming-Jun
MJ
Tsai
Yi-Hung
YH
D000180:Acrylic Resins / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D011189:Potassium Chloride / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility; D013229:Stearic Acids / Q000737:chemistry; D013499:Surface Properties; D013678:Technology, Pharmaceutical
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D013229:Stearic Acids; C050528:Eudragit RS; C031183:stearic acid; D011189:Potassium Chloride; C013517:ethyl cellulose; D002482:Cellulose