title: Follow-up of women with breast cancer: comparison between MRI and FDG PET.
abstract: The aim of this study was to compare MRI of the breast with (18)F-fluoro-deoxy-glucose (FDG) positron emission tomography (PET) in patients with suspected local or regional breast cancer recurrence or suspected contralateral breast cancer. Thirty-two patients (mean age 57.2 years, age range 32-76 years) with suspected loco-regional recurrence ( n=19), chest wall recurrence ( n=5), and suspected secondary tumor of the contralateral breast ( n=8) underwent MRI of the breast and FDG PET of the whole body and breast region. Cytology/histology ( n=17) or a clinical follow-up examination ( n=15) with additional imaging served as the standard of reference. A McNemar test was performed to compare PET and MRI, and kappa was determined to quantify agreement of both methods. Sensitivity was 79 and 100%, specificity was 94 and 72%, and accuracy was 88 and 84% for MRI and PET, respectively. Additional metastases outside the field of view of MRI were found in PET in 5 patients. In this study both imaging methods had comparable accuracy. The detection of distant metastases with whole-body PET imaging can influence patient management.
authors.affiliation: Division of Nuclear Medicine, University Hospital, Raemistrasse 100, 8091 Zurich, Switzerland. gerhard.goerres@dmr.usz.ch
authors.forename: Gerhard W
authors.initials: GW
authors.lastname: Goerres
authors.forename: Sven C A
authors.initials: SC
authors.lastname: Michel
authors.forename: Mathias K
authors.initials: MK
authors.lastname: Fehr
authors.forename: Achim H
authors.initials: AH
authors.lastname: Kaim
authors.forename: Hans C
authors.initials: HC
authors.lastname: Steinert
authors.forename: Burkhardt
authors.initials: B
authors.lastname: Seifert
authors.forename: Gustav K
authors.initials: GK
authors.lastname: von Schulthess
authors.forename: Rahel A
authors.initials: RA
authors.lastname: Kubik-Huch
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D003287:Contrast Media; D005260:Female; D019788:Fluorodeoxyglucose F18; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D019786:Gadolinium DTPA