title: Donepezil use for advanced Alzheimer's disease--a case study from a long-term care facility.
abstract: The following case describes a severely demented, elderly male patient who was placed in a nursing home when he became unmanageable in an assisted-living facility. Upon admission to the nursing facility, the patient was diagnosed with relatively severe Alzheimer's disease (AD)treated with the cholinesterase inhibitor donepezil in the context of a clinical study. This report illustrates that donepezil, and perhaps by analogy other cholinesterase inhibitors as well, can be efficacious in treating the cognitive, functional, and behavioral impairment associated with advanced AD.
authors.affiliation: Department of Psychiatry, University of Rochester Medical Center, NY 14620, USA. Piere_Tatiot@urmc.rochester.edu
authors.forename: Pierre N
authors.initials: PN
authors.lastname: Tariot
authors.forename: Laura
authors.initials: L
authors.lastname: Jakimovich
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000188:drug therapy*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D018450:Disease Progression; D000077265:Donepezil; D004311:Double-Blind Method; D016903:Drug Monitoring; D015577:Geriatric Assessment; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D008134:Long-Term Care / Q000379:methods; D008297:Male; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*; D011788:Quality of Life; D012720:Severity of Illness Index; D012866:Skilled Nursing Facilities; D016896:Treatment Outcome
chemical_list: D002800:Cholinesterase Inhibitors; D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D000077265:Donepezil