Chemoprevention of cancerogenesis--the role of sulforaphane.
Isothiocyanates are a group of naturally occurring compounds with interesting medical properties, such as antimicrobial, antioxidant and antitumor activities. In our work we were trying to present the tumoricidal activity of new synthesized derivatives of one isothiocyanate: 1-isothio-cyanato-(4R)-(methylsulfinyl) butane [sulforaphane]. Many chemical substances derived from plants, undoubtedly have protective properties. The effectiveness of sulforaphane is based on induction of hepatic detoxifying enzymes.
Sołowiej
Ewa
E
Medical University of Warsaw, Department of General and Transplantation Surgery, 59 Nowogrodzka Str., 02-006 Warsaw. esolowiej@poczta.onet.pl
Kasprzycka-Guttman
Teresa
T
Fiedor
Piotr
P
Rowinśki
Wojciech
W
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry; D005978:Glutathione / Q000378:metabolism; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D006801:Humans; D017879:Isothiocyanates; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000517:prevention & control*; D013454:Sulfoxides; D013861:Thiocyanates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D016588:Anticarcinogenic Agents; D000975:Antioxidants; D017879:Isothiocyanates; D013454:Sulfoxides; D013861:Thiocyanates; D006419:Heme Oxygenase (Decyclizing); C016766:sulforaphane; D005978:Glutathione