A confirmatory study on the mechanisms behind reduced P300 waves in depression.
A single-trial analysis of event-related potentials (P300) of 21 depressives was performed in comparison with matched controls. The purpose was to confirm previous results revealing an overall reduction of the single-trial P300 amplitude in depression despite fewer elicited single-trial P300 waves in schizophrenics. The result of the present study is in line with our previous investigation implicating a general reduced P300 amplitude on single trials of depressive patients. Therefore, it appears possible to differentiate depressives and schizophrenics by measuring event-related potentials and applying a single-trial analysis of them.
Röschke
Joachim
J
Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, 55101 Mainz, Germany. roeschke@mail.uni-mainz.de
Wagner
Peter
P
D000328:Adult; D000704:Analysis of Variance; D003865:Major Depressive Disorder / Q000503:physiopathology* / Q000523:psychology; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged