title: Some new bi- and ter-benzimidazole derivatives as topoisomerase I inhibitors.
abstract: The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. In the last years detailed investigation of bi- and ter-benzimidazole derivatives revealed that these compounds are a new class of topoisomerase I inhibitors that poisons mammalian topoisomerase I. In this context a survey about topoisomerase I poisoning activity and cytotoxicity of bi- and ter-benzimidazoles is given. Moreover some recent results about new derivatives, some structure-activity relationships and comparison of activity of various functional groups are discussed.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University 06100 Tandogan, Ankara, Turkey.
authors.forename: Sabiha
authors.initials: S
authors.lastname: Alper
authors.forename: Ozlem
authors.initials: O
authors.lastname: Temiz Arpaci
authors.forename: Esin
authors.initials: E
authors.lastname: Sener Aki
authors.forename: Ismail
authors.initials: I
authors.lastname: Yalçin
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry*; D001703:Biophysics / Q000639:trends; D002166:Camptothecin / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors
chemical_list: D001562:Benzimidazoles; D059004:Topoisomerase I Inhibitors; D002166:Camptothecin