Evaluation of analgesic effect of Datura fastuosa leaves and seed extracts.
The aqueous extracts of Datura fastuosa leaves and seeds were evaluated for the analgesic effect on acetic acid-induced writhing and hot plate reaction in mice. According to the results, D. fastuosa leaves and seeds extracts at oral doses of 400 and 800 mg/kg are effective as analgesic. The analgesic activity of leaf extract is reduced by naloxone but not that of seed extract.
Abena
A A
AA
Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, University Marien Ngouabi, BP 69, Brazzaville, Congo. abena_cg@yahoo.fr
Miguel
L M
LM
Mouanga
A
A
Hondi Assah
Th
T
Diatewa
M
M
D019342:Acetic Acid; D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D032302:Datura; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D012639:Seeds
D000700:Analgesics; D010936:Plant Extracts; D019342:Acetic Acid