[Thrombosis of the superior sagittal sinus in a breast fed infant: secondary to prolonged exposure to mesalazine?].
BACKGROUND
Mesalazine or 5 aminosalicylic acid (5 ASA) is currently a first choice drug in the treatment of inflammatory bowel disease. It has been shown that it crosses the placenta and is excreted into breast milk in small quantities.


METHODS
We present the case of a four month old breast fed infant, with a thrombosis of the superior sagittal sinus secondary to a severe thrombocytosis (1,124,000/mm3). The only interesting antecedent we would draw attention to, is that breast feeding had been suddenly stopped the week before. The mother, suffering Crohn s disease, had been receiving treatment with oral mesalazine throughout her pregnancy and during lactation.


CONCLUSIONS
Once other causes of the thrombocytosis had been eliminated, we based our approach on the hypothesis that it was due to prolonged intake of 5 ASA by the mother.
Barriuso
L M
LM
Servicio de Pediatría, Hospital Virgen del Camino, Pamplona, España.
Yoldi-Petri
M E
ME
Olaciregui
O
O
Iceta-Lizarraga
A
A
Goñi-Orayen
C
C
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001942:Breast Feeding; D002648:Child; D003392:Cranial Sinuses / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D019804:Mesalamine / Q000009:adverse effects*; D011247:Pregnancy; D011859:Radiography; D013922:Thrombocytosis; D013927:Thrombosis / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine