[Brain oedema and acute liver failure].
Brain oedema leading to intracranial hypertension occurs in a significant proportion of patients with acute liver failure in whom it is a leading cause of death. Although precise pathogenic mechanisms associated to this severe complication remain incompletely understood, increasing evidence points to gut-derived neurotoxins including ammonia as key mediators in cerebral osmotic and perfusion disturbances. The management of brain oedema and intracranial hypertension requires a multidisciplinar approach in a center where liver transplantation is available, as this option is the only treatment modality that provides improvement in outcome. This article reviews the most common causes of acute liver failure and the standard of supportive care management, and describes future potential therapeutic aspects of brain oedema and intracranial hypertension.
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Division de gastro-entérologie et d'hépatologie, département de médecine interne, hôpitaux universitaires de Genève, 24, Rue Micheli-du-Crest, 1211 14, Genève, Suisse. Laurent.Spahr@hcuge.ch <Laurent.Spahr@hcuge.ch>
D001929:Brain Edema / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D019586:Intracranial Hypertension / Q000209:etiology / Q000503:physiopathology; D017114:Liver Failure, Acute / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D016031:Liver Transplantation; D009498:Neurotoxins / Q000378:metabolism
D009498:Neurotoxins