title: Ocular changes in a limited form of Wegener's granulomatosis: patient with cutaneous ulcer of upper eyelid.
abstract: BACKGROUND
  We report a patient with a limited form of Wegener's granulomatosis (WG) who presented with ocular changes and an eyelid ulcer in her left eye.
  
  
  METHODS
  A 56-year-old woman complained of ocular pain and discharge. Upon examination, we found evidence of ulcerative keratitis, a mass in the orbit, and an eyelid skin ulcer in her left eye.
  
  
  METHODS
  The antineutrophil cytoplasmic antibody test was negative, and systemic evaluations showed no specific changes. A biopsy specimen of the left orbit demonstrated necrosis, granulomatous inflammation, and vasculitis. A diagnosis was made of a limited form of WG, whilethe biopsy specimen of the left upper lid demonstrated granulomatous inflammation without vasculitis.
  
  
  CONCLUSIONS
  Although the eyelid ulcer was contiguous with the orbital mass, histopathology showed they had distinctive pathological features.
authors.affiliation: Department of Ophthalmology, Nagoya National Hospital, Nagoya, Japan. ganiky@nnh.hosp.go.jp
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Kubota
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirose
mesh_terms: D003320:Corneal Ulcer / Q000175:diagnosis / Q000209:etiology; D005141:Eyelid Diseases / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D009916:Orbital Diseases / Q000175:diagnosis / Q000209:etiology; D012883:Skin Ulcer / Q000175:diagnosis / Q000209:etiology*