Expression of FERM domain including guanine nucleotide exchange factor mRNA in adult rat brain.
FERM domain including Rho GEF (FIR) belongs to Dbl family of guanine nucleotide exchange factors and specifically activates biochemical pathways specific for Rac1. FIR was shown to regulate neurite remodeling of the embryonic neurons. Here we report a distribution of FIR mRNA in adult rat brain using in situ hybridization. The expression was found all throughout the brain with the most intensive signals in hippocampus, piriform cortex, red nucleus and nuclei of cranial nerves. The signal was predominantly localized in the neuronal cells.
Madura
Tomas
T
Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Yamashita
Toshihide
T
Kubo
Tateki
T
Taniguchi
Manabu
M
Kawakita
Akihiro
A
Hosokawa
Ko
K
Tohyama
Masaya
M
D000375:Aging / Q000235:genetics*; D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics*; D009474:Neurons / Q000378:metabolism*; D017434:Protein Structure, Tertiary / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D064067:Rho Guanine Nucleotide Exchange Factors; D020830:rac1 GTP-Binding Protein / Q000378:metabolism*
C577426:FARP2 protein, human; D020662:Guanine Nucleotide Exchange Factors; D012333:RNA, Messenger; D064067:Rho Guanine Nucleotide Exchange Factors; D020830:rac1 GTP-Binding Protein