The activation of lymphocytes is in their CARMA.
Lymphocyte activation via antigen receptors initiates adaptive immune responses. Two papers in this issue of Immunity demonstrate that CARMA-1, a CARD carrying member of the MAGUK family proteins, is essential for lymphocyte activation. CARMA-1 functions by coupling antigen receptor signals to NF-kappaB induction and JNK activation.
Abbas
Abul K
AK
Department of Pathology, University of California San Francisco School of Medicine, San Francisco, CA 94143, USA.
Sen
Ranjan
R
D000818:Animals; D051528:Guanylate Kinases; D048031:JNK Mitogen-Activated Protein Kinases; D008214:Lymphocytes / Q000201:enzymology / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009154:Mutation; D009703:Nucleoside-Phosphate Kinase / Q000235:genetics / Q000378:metabolism*
D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases; D009703:Nucleoside-Phosphate Kinase; D051528:Guanylate Kinases