[Dynamic changes in synovitis activity after intra-articular administration of xefocam in patients with rheumatoid arthritis (according to clinical and device examinations)].
OBJECTIVE
To assess efficacy of intraarticular administration of lornoxicam (xefocam) in patients with rheumatoid arthritis (RA).


METHODS
Xefocam was injected into the knee joints of 58 patients with RA once a week for 3 weeks in a dose 8 mg. The treatment efficacy was evaluated by changes in the severity of arthralgias, pain in the joints at palpation, circumference of the knee joints at the level of the upper edge of the patella, ultrasound and thermography of the knee joints.


RESULTS
Xefocam relieved arthralgia (in 44 patients at least by 30%), pain in the joints at palpation and joint circumference. Ultrasound investigation registered a significant thinning of the synovial membrane and amount of exudates.


CONCLUSIONS
If local steroid therapy is not definitely indicated, intraarticular administration of xefocam can be effectively used for suppression of moderate inflammation in the joints in RA patients.
Balabanova
R M
RM
Fedina
T P
TP
Tsurko
V V
VV
Mach
E S
ES
Khitrov
N A
NA
Agapova
L A
LA
Oliunin
Iu A
IuA
Pushkova
O V
OV
Apenysheva
N P
NP
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010894:Piroxicam / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D013585:Synovitis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; C059451:lornoxicam