title: [Results of accelerated hyperfractionated radiotherapy in breast conserving therapy: a pilot study].
abstract: We performed a pilot study to evaluate the safety, tolerability and clinical usefulness of accelerated hyperfractionated radiotherapy in patients treated with breast conserving therapy (BCT). The radiotherapy was consisted of 1.5 Gy per fraction twice daily to a total dose of 51 Gy to the whole breast with or without 9 Gy boost to the tumor bed in case of positive surgical margin. Thirty-seven patients were treated with accelerated hyperfractionated radiotherapy and 178 patients with conventional radiotherapy between September 1993 and December 1997. Acute or late skin toxicity of Grade 3 or more was not observed. One case of radiation pneumonitis requiring steroid therapy occurred in the conventional group. 8-year local-relapse-free survivals were 100% in accelerated group and 97.0% in conventional group (not significant: p = 0.59). The scores in quality of life at one year after the completion of radiation therapy were not different between the conventional and the accelerated group; symptomatic scores, global QOL scores, and scores by self-estimation for therapy. Admission charges in conventional and in accelerated group were not different, either. These data suggested that accelerated hyperfractionated radiotherapy in BCT was feasible and phase III study to compare conventional with the accelerated hyperfractionated radiotherapy should be planned to evaluate its clinical usefulness in BCT.
authors.affiliation: Department of Radiology, National Shikoku Cancer Center Hospital.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kataoka
authors.forename: Shuichi
authors.initials: S
authors.lastname: Shinohara
authors.forename: Takashi
authors.initials: T
authors.lastname: Ochi
authors.forename: Kana
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Miho
authors.initials: M
authors.lastname: Ikura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hyoudou
authors.forename: Takeshi
authors.initials: T
authors.lastname: Inoue
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mogami
authors.forename: Masashi
authors.initials: M
authors.lastname: Kawamura
authors.forename: Shigemitsu
authors.initials: S
authors.lastname: Takashima
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D010865:Pilot Projects; D011379:Prognosis; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant / Q000191:economics / Q000379:methods