Steroidogenic acute regulatory protein expression in the normal human brain and intracranial tumors.
In this study we found the expression of steroidogenic acute regulatory protein (StAR) mRNA and protein in both the normal human brain and intracranial tumors, using RT-PCR and immunohistochemistry. StAR mRNA is expressed at a very low level in the white matter of the normal human brain, but in tumoral tissues StAR mRNA was specifically expressed in oligodendrogliomas and malignant glial tumors. StAR-positive cells were also detected in the normal human brains and gliomas; its frequency and density were higher in glioma tissue. These findings suggest that StAR expression might be correlated with the growth of glial tumors.
Kim
Hyun Joon
HJ
Department of Anatomy, Institute of Health Science, College of Medicine, Gyeongsang National University, 92 Chilam-dong, Jinju 660-751, South Korea.
Kim
Jeong Eun
JE
Ha
Myung
M
Kang
Sang Soo
SS
Kim
Jong Tae
JT
Park
In Sung
IS
Paek
Sun Ha
SH
Jung
Hee-Won
HW
Kim
Dong Gyu
DG
Cho
Gyeong Jae
GJ
Choi
Wan Sung
WS
D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005910:Glioma / Q000145:classification / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D000098682:Steroidogenic Acute Regulatory Protein
D005904:Glial Fibrillary Acidic Protein; D010750:Phosphoproteins; D012333:RNA, Messenger; D000098682:Steroidogenic Acute Regulatory Protein