FoxP4, a novel forkhead transcription factor.
Forkhead proteins have been demonstrated to play key roles in embryonic development, cell cycle regulation, and oncogenesis. We report the characterization of a new forkhead transcription factor, which is a member of the FoxP subfamily. In adult tissues FoxP4 is expressed in heart, brain, lung, liver, kidney, and testis. By Northern hybridization, very low levels of FoxP4 expression were found as early as E7 during embryonic development. Embryonic expression was highest at E11 and subsequently decreased at E15 and E17. In situ hybridization revealed expression of FoxP4 in the developing lung and gut, suggesting a role for FoxP4 during the development of these organs. In addition, FoxP4 was found to be significantly reduced in patients with kidney tumors. Lastly, FoxP4 matches an uncharacterized human EST that has previously been shown to be down-regulated in larynx carcinoma.
Teufel
Andreas
A
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Building 6B, Room 413, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Wong
Eric A
EA
Mukhopadhyay
Mahua
M
Malik
Nasir
N
Westphal
Heiner
H
D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D004064:Digestive System / Q000196:embryology; D051858:Forkhead Transcription Factors; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics; D008168:Lung / Q000196:embryology; D051379:Mice; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; C472854:Foxp4 protein, mouse; D014157:Transcription Factors