[Endothelium-dependent and independent vasodilation in young males with previous myocardial infarction].
BACKGROUND
Flow-mediated vasodilatation of brachial arteries, a non-invasive parameter of endothelial function, is correlated with cardiovascular risk factors. An impairment of flow-mediated vasodilatation in the brachial artery is related to the extent of coronary artery disease.


OBJECTIVE
The authors examined the relationship between flow-mediated vasodilatation and coronary artery disease morphology in young patients who had myocardial infarction.


METHODS
28 young patients (all men) with myocardial infarction (age 22-40, mean age: 35 years). Coronarography revealed one vessel disease in 16 patients (A group) and multivessel disease in 12 patients (B group). The control group was 14 healthy, young patients (age 18-36 years mean age: 30 years) (C group). The authors examined in all subjects flow-mediated, endothelium-dependent vasodilatation following reactive hyperaemia and nitroglycerin induced (NTG), endothelium-independent vasodilatation in the brachial artery with high resolution ultrasound (Acuson 128 X P/10).


RESULTS
Patients after myocardial infarction showed impaired flow-mediated vasodilatation compared to those of controls. (p < 0.01). Flow-mediated vasodilatation was lower in multivessel disease compare to one vessel disease. Nitroglycerin induced similar degrees of vasodilatation in the myocardial infarction and control groups.


CONCLUSIONS
Young patients with myocardial infarction may have impaired endothelium-dependent dilatation and the decrease of flow-mediated vasodilatation is related to the angiographic extent of coronary artery disease.
Vértes
András
A
Gottsegen György Országos Kardiológiai Intézet, Kardiológiai Osztály, Budapest.
Káli
András
A
D000328:Adult; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000503:physiopathology*; D005996:Nitroglycerin / Q000008:administration & dosage; D012307:Risk Factors; D014664:Vasodilation; D014665:Vasodilator Agents / Q000008:administration & dosage
D014665:Vasodilator Agents; D005996:Nitroglycerin