Two unusual acetogenins from the roots of Annona salzmanii.
Two new acetogenins, parisin (1) and salzmanolin (2), were isolated from a MeOH extract of the roots of Annona salzmanii. The structures of 1 and 2 were elucidated by spectroscopic methods including LSI-MS/MS, on both the natural compounds and their acetonide derivatives (1a and 2a). Compounds 1 and 2 showed significant activity against the KB and Vero cell lines.
Queiroz
Emerson F
EF
Laboratoire de Pharmacognosie, CNRS UPRES-A 8076 (BIOCIS), Faculté de Pharmacie, 92296 Châtenay-Malabry, France. Emerson.ferreiraqueiroz@ipp.unil.ch
Roblot
François
F
Laprévote
Olivier
O
Paulo
Marçal de Q
Mde Q
Hocquemiller
Reynald
R
D000818:Animals; D031041:Annona / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D002522:Chlorocebus aethiops; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014709:Vero Cells
D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; C478443:parisin; C478444:salzamanolin