title: The antioxidant system.
abstract: The glutathione (GSH) antioxidant system is the principal protective mechanism of the cell and is a crucial factor in the development of the immune response by the immune cells. Experimental data demonstrate that a cysteine-rich whey protein concentrate represents an effective cysteine delivery system for GSH replenishment during the immune response. Animal experiments showed that the concentrates of whey protein also exhibit anticancer activity. They do this via the GSH pathway, the induction of p53 protein in transformed cells and inhibition of neoangiogenesis.
authors.affiliation: Research and Development Department, Immunotec Research Ltd., 292 Adrien Patenaude, Vaudreuil-Dorion, Québec, Canada J7V 5V5.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Bounous
authors.forename: John H
authors.initials: JH
authors.lastname: Molson
mesh_terms: D000111:Acetylcysteine / Q000493:pharmacokinetics / Q000627:therapeutic use; D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism*; D003545:Cysteine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D004044:Dietary Proteins / Q000032:analysis / Q000627:therapeutic use; D005978:Glutathione / Q000502:physiology*; D006801:Humans; D051379:Mice; D008805:Mice, Inbred A; D008894:Milk Proteins / Q000737:chemistry / Q000627:therapeutic use; D008954:Models, Biological; D009369:Neoplasms / Q000178:diet therapy / Q000188:drug therapy; D009374:Neoplasms, Experimental / Q000178:diet therapy / Q000188:drug therapy; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011355:Prodrugs / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D000067816:Whey Proteins
chemical_list: D000276:Adjuvants, Immunologic; D000596:Amino Acids; D000970:Antineoplastic Agents; D000975:Antioxidants; D004044:Dietary Proteins; D008894:Milk Proteins; D011355:Prodrugs; D000067816:Whey Proteins; D005978:Glutathione; D003545:Cysteine; D000111:Acetylcysteine