Autoreactive T cell responses in pemphigus and pemphigoid.
Pemphigus and pemphigoid are cutaneous autoimmune diseases characterised by autoantibodies directed against specific adhesion proteins of the epidermis and dermal-epidermal junction. These proteins are usually associated with desmosomes or hemidesmosomes. Binding of antibodies to their targets leads to the loss of cell-cell or cell-matrix adhesion and subsequently to blister formation. The humoral aspects of the autoimmune responses in pemphigus and pemphigoid have been extensively studied in the past. More recently, the cellular interactions resulting in the formation of autoantibodies and the involvement of autoreactive T cells in these diseases have attracted increased interest. In this review, the current knowledge on T cell involvement in pemphigus and pemphigoid is summarised.
Oostingh
Gertie J
GJ
Department of Dermatology, University of Würzburg, Josef-Schneider Str. 2, 97080 Wurzburg, Germany.
Sitaru
Cassian
C
Kromminga
Arno
A
Dormann
Dirk
D
Zillikens
Detlef
D
D000938:Antigen-Presenting Cells / Q000276:immunology; D001324:Autoantigens; D015551:Autoimmunity; D006801:Humans; D008213:Lymphocyte Activation; D018448:Models, Immunological; D010391:Pemphigoid, Bullous / Q000276:immunology*; D010392:Pemphigus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D001324:Autoantigens