A neurodevelopmental model for anorexia nervosa.
This paper integrates genetic and biological data on aetiological risk for anorexia nervosa (AN) with cognitive and psychosocial explanatory models. We have reviewed clinical and basic science data from each of these domains and then used a developmental perspective to formulate a multifactorial threshold model. By positioning interpersonal stress as a central component of this model, psychological, social and biological conceptualisations of AN can be used to generate a data driven, neurodevelopmental hypothesis for the aetiology of this complex disorder.
Connan
Frances
F
Institute of Psychiatry, Kings College London, London SE5 8PF, UK. f.connan@iop.kcl.ac.uk
Campbell
Iain C
IC
Katzman
Melanie
M
Lightman
Stafford L
SL
Treasure
Janet
J
D000223:Adaptation, Psychological / Q000502:physiology; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000818:Animals; D000856:Anorexia Nervosa / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology; D001127:Arginine Vasopressin / Q000502:physiology; D001143:Arousal / Q000235:genetics / Q000502:physiology; D001921:Brain / Q000503:physiopathology; D002648:Child; D003346:Corticotropin-Releasing Hormone / Q000502:physiology; D004195:Disease Models, Animal; D004200:Diseases in Twins / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006380:Helplessness, Learned; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008297:Male; D009769:Object Attachment; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011627:Puberty / Q000235:genetics / Q000502:physiology / Q000523:psychology; D012307:Risk Factors; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology
D001127:Arginine Vasopressin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone