Transient hypohidrosis induced by topiramate.
OBJECTIVE
Hypohidrosis during topiramate (TPM) treatment was recently reported in children. We describe an adult epilepsy patient who developed inability to sweat as well as heat intolerance while undergoing treatment with TPM.


METHODS
To detect the site of the sweat block, patient underwent examination of sweat gland function, cardiovascular autonomic test, and body temperature rhythm determination.


RESULTS
During TPM treatment, cardiovascular autonomic function and circadian rhythm of body core temperature were normal, whereas thermoregulatory sweat test (TST) showed anhydrosis. This adverse drug effect was quickly resolved after drug discontinuation.


CONCLUSIONS
Because of normal cardiovascular autonomic function and central and peripheral thermoregulatory mechanisms, we hypothesize that hypohidrosis during TPM treatment could be due to a carbonic anhydrases (CA) block at the level of sweat gland.
de Carolis
Piero
P
Department of Neurological Sciences, University of Bologna, Bologna, Italy.
Magnifico
Fabiola
F
Pierangeli
Giulia
G
Rinaldi
Rita
R
Galeotti
Massimo
M
Cevoli
Sabina
S
Cortelli
Pietro
P
D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D001833:Body Temperature Regulation / Q000187:drug effects; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004828:Epilepsies, Partial / Q000188:drug therapy*; D017029:Epilepsy, Complex Partial / Q000188:drug therapy*; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D006359:Heat Exhaustion / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007007:Hypohidrosis / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D013546:Sweating / Q000187:drug effects; D000077236:Topiramate
D000927:Anticonvulsants; D002257:Carbonic Anhydrase Inhibitors; D000077236:Topiramate; D005632:Fructose