title: Tissue metal concentrations and histopathology of rats gavaged with vitrified soil obtained from the former Charleston Naval Shipyard (SC, USA).
abstract: Male Sprague Dawley rats were administered a vitrified material obtained from the former Charleston Naval Shipyard (Charleston, SC, USA) by gavage once daily for 32 days. Group mean body weight of treated animals was within +/-5.4% of controls. No gross or histopathological changes were observed when animals were treated with 67, 174, or 370 mg/kg per day. Analysis of heavy metals revealed a statistically significant increase only in the concentration of arsenic in the livers of animals treated with 174 or 370 mg/kg per day versus controls. Although there was a statistically significant increase in liver arsenic levels, the concentrations were far below mean soil concentrations for western and eastern United States. If the standard assumption of 100% absorption is used, the concentrations observed in the present study are about 20 times less than the average background soil levels in these regions. Based on this, it is concluded that the vitrified material would not pose a public health risk for its intended use as an additive for asphalt and glass beams.
authors.affiliation: Center for Environmental and Occupational Risk Analysis and Management, Department of Environmental and Occupational Health, College of Public Health, University of South Florida, 13201 Bruce B. Downs Blvd. MDC 56, Tampa, FL 33612-3805, USA.
authors.forename: Roland C
authors.initials: RC
authors.lastname: Garipay
authors.forename: Carlos
authors.initials: C
authors.lastname: Muro-Cacho
authors.forename: Abdelmalek
authors.initials: A
authors.lastname: Khlifi
authors.forename: Gary
authors.initials: G
authors.lastname: Hahn
authors.forename: Todd
authors.initials: T
authors.lastname: Stedeford
authors.forename: Marek
authors.initials: M
authors.lastname: Banasik
authors.forename: Raymond D
authors.initials: RD
authors.lastname: Harbison
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008099:Liver / Q000737:chemistry / Q000473:pathology; D008297:Male; D019216:Metals, Heavy / Q000032:analysis / Q000493:pharmacokinetics*; D008889:Military Personnel; D016273:Occupational Exposure; D051381:Rats; D017207:Rats, Sprague-Dawley; D018570:Risk Assessment; D012767:Ships; D012989:Soil Pollutants / Q000032:analysis / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D019216:Metals, Heavy; D012989:Soil Pollutants