Formal [3 + 2] cycloadditions of donor-acceptor cyclopropanes and nitriles.
Donor-acceptor cyclopropanes activated with Me3SiOTf cleave to reactive intermediates that can be efficiently intercepted by nitriles in a formal [3 + 2] dipolar cycloaddition reaction. Aliphatic, aromatic, and alpha,beta-unsaturated nitriles are excellent reaction partners, giving synthetically useful 2H-3,4-dihydropyrrole cycloaddition products in high yield.
Yu
Ming
M
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712, USA.
Pagenkopf
Brian L
BL