Intrathecal baclofen for stiff-person syndrome: life-threatening intermittent catheter leakage.
Intrathecal baclofen (ITB) is used for unresponsiveness to other treatment for patients with stiff-person syndrome (SPS). The authors report a patient with SPS who developed acute and life-threatening baclofen withdrawal symptoms. Open surgery disclosed a small position-dependent leak in the catheter connector. This catheter failure was not detected by standard noninvasive checking methods.
Bardutzky
J
J
Department of Neurology, University of Heidelberg, Germany. juergen_bardutzky@med.uni-heidelberg.de
Tronnier
V
V
Schwab
S
S
Meinck
H-M
HM
D000208:Acute Disease; D000328:Adult; D001418:Baclofen / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002404:Catheterization / Q000009:adverse effects*; D004868:Equipment Failure; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D015918:Infusion Pumps, Implantable / Q000009:adverse effects*; D007278:Injections, Spinal / Q000295:instrumentation; D008297:Male; D009102:Multiple Organ Failure / Q000139:chemically induced; D009125:Muscle Relaxants, Central / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013035:Spasm / Q000139:chemically induced*; D016750:Stiff-Person Syndrome / Q000188:drug therapy*; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D013610:Tachycardia / Q000139:chemically induced*
D009125:Muscle Relaxants, Central; D001418:Baclofen