Development and validation of a high-performance liquid chromatography assay for voriconazole.
An analytical method for the determination of voriconazole (UK-109,496; Pfizer) in plasma was developed and validated. The method utilizes solid-phase extraction technology and high-performance liquid chromatography. The lower limit of quantitation is 0.2 microg/ml, and the range of linearity tested was 0.2 to 10 microg/ml.
Pennick
Gennethel J
GJ
Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA. pennick@uthscsa.edu
Clark
Martin
M
Sutton
Deanna A
DA
Rinaldi
Michael G
MG
D000935:Antifungal Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods* / Q000592:standards; D011743:Pyrimidines / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014230:Triazoles / Q000032:analysis*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole