Genetic traits of the mosquito Anopheles gambiae: red stripe, frizzled, and homochromy1.
The expression, inheritance, and linkage relationships of three genetic traits were studied in the malaria vector Anopheles gambiae. Red stripe (Rs) is a common phenotypic polymorphism in numerous A. gambiae populations, whereas frizzled (f) and homochromy1 (hom1) were isolated from (60)Co-irradiated mosquitoes. Red stripe appears as a diffuse stripe of pigment on the dorsum of larvae and pupae and is variable in expressivity and penetrance. Our data demonstrate that Red stripe results from a heterozygous collarless genotype (i.e., c+ c, chromosome 2) and is essentially sex-limited to females. frizzled is a sex-linked recessive semi-lethal identified by deformed lateral larval setae; its lethality manifests as low rates of adult emergence and brief adult survival. frizzled is located on the X chromosome between pink eye and Mosaic, 3 cM from Mosaic and approximately 12 cM from pink eye. Finally, the mutation homochromy1 (hom1) is on chromosome 2 and causes a recessive phenotype that prevents normal darkening of larvae when reared in a black container. Unlike mutants with this characteristic described thus far, the eye color of hom1 mutants is normal. We determined that hom1 is located between Dieldrin resistance and collarless, approximately 3 cM from the latter. We discuss the possibility of differences in male and female recombination values and the range of values that have been observed in test crosses for chromosome 2 markers.
Benedict
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MQ
Centers for Disease Control and Prevention, Division of Parasitic Diseases, 4770 Buford Highway, Atlanta, GA 30341, USA. MBenedict@cdc.gov
McNitt
L M
LM
Collins
F H
FH
D000483:Alleles; D000818:Animals; D000852:Anopheles / Q000235:genetics*; D003433:Crosses, Genetic; D005260:Female; D017344:Genes, Insect; D008040:Genetic Linkage; D008297:Male; D009154:Mutation; D010641:Phenotype; D014960:X Chromosome