Polysomy 8 in three cases of homologous malignant mixed Müllerian tumors of the uterus.
Unique genetical gain of 8q and/or polysomy 8 identified after short-term culture are presented in three cases of malignant mixed Müllerian tumors (MMMT) of the uterus. All tumors revealed abnormal karyotypes and modal chromosome numbers in the hyperdiploid range. Two out of three cases exclusively demonstrated numerical aberrations, most prominently polysomy 8. One tumor revealed tetrasomy 8 as the sole aberration. The third tumor showed a more complex karyotype, including two unbalanced translocations, leading to partial gain of 8q. These cytogenetic findings, together with 14 previously reported cases of MMMT and 5 cell lines, suggest a distinct subgroup of endometrial MMMT characterized by gain of chromosome 8 or 8q.
Gunawan
Bastian
B
Institute of Pathology, Georg August University Hospital, Göttingen, Robert-Koch-Str. 40, D-37075 Göttingen, Germany.
Baumhoer
Daniel
D
Schulten
Hans-Jürgen
HJ
Emons
Günter
G
Füzesi
László
L
D000368:Aged; D000782:Aneuploidy; D002478:Cells, Cultured / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D018200:Mixed Tumor, Mullerian / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic; D014594:Uterine Neoplasms / Q000235:genetics* / Q000473:pathology