A license to kill: transcriptional activation and enhanced turnover of Myc by the SCF(kp2) ubiquitin ligase.
Understanding the mechanisms through which the abundance and activity of the Myc oncoprotein is regulated has been a major preoccupation of the cancer and transcription communities. New work, published in the May issue of Molecular Cell, reveals that ubiquitination of Myc by the oncogenic SCF(Skp2) complex not only promotes Myc turnover but is also required for Myc transcriptional activation, suggesting that Myc activity is "licensed" by ubiquitination.
Jin
Jianping
J
Harper
J Wade
JW
D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D044786:S-Phase Kinase-Associated Proteins / Q000502:physiology*; D015533:Transcriptional Activation; D014452:Ubiquitins / Q000502:physiology
D016271:Proto-Oncogene Proteins c-myc; D044786:S-Phase Kinase-Associated Proteins; D014452:Ubiquitins