title: Multivariate analysis of the prognostic determinants of the depressor response to exercise therapy in patients with essential hypertension.
abstract: This study investigated the contribution of hemodynamic and humoral factors to the variation in the depressor responses to exercise therapy and the significance of the baseline values of these factors in predicting the depressor response of essential hypertensives to mild exercise therapy. Patients with mild to moderate essential hypertension (n=122, F/M: 97/25) performed a bicycle ergometer exercise at a workload equivalent to the lactate threshold for 10 weeks. In all of the patients, systolic and diastolic blood pressures (BP) significantly decreased after 1 week of exercise, continued to decrease until 4 weeks, and were stable from 4 weeks to 10 weeks. Changes in the plasma volume and humoral factors during the study did not differ significantly between responders and non-responders. A multiple logistic regression analysis showed that higher baseline mean BP (MBP) was significantly associated with a poor depressor response (odds ratio 1.84, p=0.002). A variance component analysis indicated that baseline MBP accounted for only 11.2% of the total variance of the depressor response. In conclusion, these summarized results showed that variations in the depressor response to mild exercise therapy were partly determined by baseline MBP, but not by humoral factors, suggesting the possible involvement of other factors, including genetic factors.
authors.affiliation: Department of Cardiology, Fukuoka University School of Medicine, Japan.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Takaaki
authors.initials: T
authors.lastname: Sakai
authors.forename: Keita
authors.initials: K
authors.lastname: Noda
authors.forename: Akira
authors.initials: A
authors.lastname: Kiyonaga
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Munehiro
authors.initials: M
authors.lastname: Shindo
authors.forename: Keijiro
authors.initials: K
authors.lastname: Saku
mesh_terms: D015308:Anaerobic Threshold; D000704:Analysis of Variance; D001794:Blood Pressure; D016002:Discriminant Analysis; D005080:Exercise Test; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology* / Q000628:therapy*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011379:Prognosis
chemical_list: D007770:L-Lactate Dehydrogenase