title: Prevention of nosocomial lower respiratory tract infections in patients after intracranial artery aneurysm surgery with a short course of antimicrobials.
abstract: Nosocomial infections at a department of neurosurgery were followed prospectively. In 1999, a high incidence of nosocomial lower respiratory tract infections (NLRTI) was observed in patients after intracranial artery aneurysm surgery (ICAAS). From February to December 2000, a short course of ciprofloxacin and co-trimoxazole was given prophylactically to all patients with ICAAS. The incidence of nosocomial infections in patients after ICAAS fell from 78.4 to 30.9% (P<0.0001). The incidence of NLRTI fell from 43.3 to 13.6% (P<0.0001) and the incidence of urinary tract infections from 12.4 to 2.5% (P=0.015). No significant change in antibiotic sensitivity at the department was observed. Antibiotic use decreased from 100.4 defined daily doses (DDD) to 85.4 DDD per 100 bed-days.
authors.affiliation: Department of Infectious Diseases, University Medical Centre, Japljeva 2, SI-1000 Ljubljana, Slovenia. bojana.beovic@mf.uni-lj.si
authors.forename: Bojana
authors.initials: B
authors.lastname: Beovic
authors.forename: Bostjan
authors.initials: B
authors.lastname: Matos
authors.forename: Roman
authors.initials: R
authors.lastname: Bosnjak
authors.forename: Katja
authors.initials: K
authors.lastname: Seme
authors.forename: Manica
authors.initials: M
authors.lastname: Mueller-Premru
authors.forename: Veronika
authors.initials: V
authors.lastname: Hergouth-Krizan
authors.forename: Milan
authors.initials: M
authors.lastname: Cizman
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002939:Ciprofloxacin / Q000008:administration & dosage; D003428:Cross Infection / Q000517:prevention & control*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control*; D012141:Respiratory Tract Infections / Q000517:prevention & control*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination