title: [Two adult cases of unilateral schizencephaly manifesting as minor neurological signs--importance of radiographic CT assessment].
abstract: We report two adult cases of unilateral schizencephaly manifesting as minor neurological signs. Case 1 was a 52-year-old female with an attack of partial seizure. CT demonstrated a closed cleft in the left frontal lobe. MRI revealed that the cleft was covered with gray matter, and was extending to the ventricular wall. Her epileptic seizure was successfully controlled by medication. Case 2 was a 58-year-old female with a history of mild right hemiparesis from her birth. CT demonstrated a closed cleft in the left peri-Rolandic area. MRI revealed a cortical infolding which extended to the lateral ventricle, and complication with polymicrogyria. Two patients were diagnosed as having normal intelligence, and unilateral schizencephalies with closed-lip. There has appeared to be more reports in the recent literature dealing with unilateral schizencephaly with mildly neurologic dysfunction. It is sufficiently capable of making such a diagnosis for schizencephaly by initial CT evaluation of a detailed radiographic assessment, in which characteristic findings with focal enlargement of cortical sulci or appearance of cortical infolding extending to deep white matter will be detected, though MRI is considered to be useful for a more detailed neuroanatomical evaluation.
authors.affiliation: Department of Neurosurgery, Okinawa Prefectural Miyako Hospital, 807 Higashi-Nakasone, Hirara, Okinawa 906-0007, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Oshiro
authors.forename: Takeo
authors.initials: T
authors.lastname: Fukushima
mesh_terms: D001921:Brain / Q000002:abnormalities* / Q000000981:diagnostic imaging* / Q000473:pathology; D004827:Epilepsy / Q000209:etiology*; D005260:Female; D005625:Frontal Lobe / Q000002:abnormalities / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D014057:Tomography, X-Ray Computed