title: Comparison of the effect of two excipients (karite nut butter and vaseline) on the efficacy of Cocos nucifera, Elaeis guineensis and Carapa procera oil-based repellents formulations against mosquitoes biting in Ivory Coast.
abstract: Repellents in the form of dermal pomades are recommended as a protection against awakening and bedtime mosquito bites. If synthesis repellents are available, they are nevertheless not common and the prices remain out of reach for the communities concerned. The people therefore have to resort more and more to traditional concoctions, some of which have been shown to be effective. After demonstrating that oil-based formulations (lotions, creams, pomades) of Cocos nucifera (coconut), Elaeis guineensis (oil palm) and Carapa procera (gobi) were effective against mosquitoes, it became necessary to study the impact of the two excipients used in their manufacture, on the effectiveness of the repellents. Experiments were carried with Anopheles gambiae and Aedes aegypti under lobaratory conditions and any other mosquitoes collected under field conditions in Ivory Coast. The laboratory results indicate that the average protection times obtained with formulations with karite nut butter as excipient (54.8 +/- 37.0 mn and 74.6 +/- 26.4 mn respectively on An. gambiae and Ae. aegypti) are higher than those recorded with vaseline as excipient (respectively 42.7 +/- 30.0 mn and 60.8 +/- 33.9 mn). On the other hand, under field conditions, the biting rate percentage reduction obtained with the products with karite nut butter and vaseline excipient were similar (respectively 29.8% and 35.9% for all mosquitoes collected and 45.7% and 47.4% against An. gambiae). Nevertheless, the use of karite nut butter on repellent products should be encouraged because its sale price is very lower (10 time less) than the vaseline's.
authors.affiliation: Pierre Richet Institute, 01 BP 1500 Bouaké 01, Ivory Coast. lucien_konan@yahoo.fr
authors.forename: Y L
authors.initials: YL
authors.lastname: Konan
authors.forename: M S
authors.initials: MS
authors.lastname: Sylla
authors.forename: J M
authors.initials: JM
authors.lastname: Doannio
authors.forename: S
authors.initials: S
authors.lastname: Traoré
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000074263:Coconut Oil; D007560:Cote d'Ivoire; D009033:Culicidae; D005079:Excipients / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007299:Insect Bites and Stings / Q000517:prevention & control*; D007302:Insect Repellents / Q000494:pharmacology / Q000592:standards*; D009032:Mosquito Control / Q000379:methods*; D000073878:Palm Oil; D010577:Petrolatum / Q000737:chemistry / Q000494:pharmacology; D010938:Plant Oils / Q000737:chemistry*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005079:Excipients; D007302:Insect Repellents; D010938:Plant Oils; D000073878:Palm Oil; D010577:Petrolatum; D000074263:Coconut Oil