A novel carbohydrate-derived side-chain polyether with excellent protein resistance.
A novel carbohydrate-derived side-chain polyether was synthesized as a new biomaterial by condensation polymerization of monomers derived from natural occurring carbohydrates. Surface plasmon resonance spectroscopy studies demonstrated that this side-chain polyether has excellent resistance to nonspecific protein adsorption. The protein resistant capability of the side-chain polyether is comparable to that of oligoethylene glycol, a main-chain polyether that is, to date, the best protein resistant material. In addition to the excellent biocompatibility, the new polymer also combines biodegradability and functionalizability. With these combined good properties, this side-chain polyether is envisioned as a new biomaterial for many potential biomedical applications.
Metzke
Mark
M
Department of Chemistry, 516 Rowland Hall, University of California-Irvine, Irvine, CA 92697-2025, USA.
Bai
Jane Z
JZ
Guan
Zhibin
Z
D000327:Adsorption; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D005340:Fibrinogen / Q000737:chemistry*; D009113:Muramidase / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D020349:Surface Plasmon Resonance
D001672:Biocompatible Materials; D004987:Ethers; D011108:Polymers; D011092:Polyethylene Glycols; D005340:Fibrinogen; D009113:Muramidase