title: Uterine tumor resembling ovarian sex-cord tumor: report of a case mimicking cervical adenocarcinoma.
abstract: Uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) are unusual neoplasms with histologic features that resemble those within ovarian Sertoli and granulosa cell tumors. We report the case of a 24-year-old woman with a UTROSCT presenting as a cervical mass, which on initial evaluation was thought to represent cervical adenocarcinoma. The patient's cervical biopsy specimen contained epithelioid cells arranged in tubules and anastomosing cords, without significant cellular atypia or mitotic activity. Because this morphology elicited a broad differential diagnosis, immunohistochemical studies were performed. The tumor was found to be diffusely positive for cytokeratin cocktail, calretinin, and desmin, focally positive for CK7 and SMA, and negative for EMA, CEA, inhibin, CD10, CK20, chromogranin, and synaptophysin. Ultrastructural examination revealed occasional gland-like lumens with cells joined by desmosomes and a continuous basal lamina. UTROSCTs have features that may cause them to be confused with more common tumors, especially in limited biopsy samples, and should be included in the differential diagnosis when a gland-forming neoplasm with an unusual appearance is identified in a cervical or endometrial biopsy specimen.
authors.affiliation: Department of Pathalogy, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: Wareef
authors.initials: W
authors.lastname: Kabbani
authors.forename: Michael T
authors.initials: MT
authors.lastname: Deavers
authors.forename: Anais
authors.initials: A
authors.lastname: Malpica
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Burke
authors.forename: Jinsong
authors.initials: J
authors.lastname: Liu
authors.forename: Nelson G
authors.initials: NG
authors.lastname: Ordoñez
authors.forename: Anuja
authors.initials: A
authors.lastname: Jhingran
authors.forename: Elvio G
authors.initials: EG
authors.lastname: Silva
mesh_terms: D000199:Actins / Q000032:analysis; D000230:Adenocarcinoma; D000328:Adult; D001706:Biopsy; D064032:Calbindin 2; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D003893:Desmin / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D053552:Keratin-7; D007633:Keratins / Q000032:analysis; D008854:Microscopy, Electron; D009130:Muscle, Smooth / Q000737:chemistry; D010051:Ovarian Neoplasms; D064030:S100 Calcium Binding Protein G / Q000032:analysis; D018312:Sex Cord-Gonadal Stromal Tumors; D002583:Uterine Cervical Neoplasms; D014594:Uterine Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery
chemical_list: D000199:Actins; C576764:CALB2 protein, human; D064032:Calbindin 2; D003893:Desmin; C507497:KRT7 protein, human; D053552:Keratin-7; D064030:S100 Calcium Binding Protein G; D007633:Keratins