Convenient preparation and use of a new analytical construct for the analysis and development of solid-phase chemistries.
An expedient and scalable synthesis of a versatile new analytical construct intermediate 1 is described. The utility of the intermediate 1 is exemplified by the preparation of the construct resin 14 incorporating an acid-labile linker which is used to conveniently develop optimized conditions leading to the preparation of a small compound array 24(1-3,1-3). The optimized conditions are shown to work equally well on both the construct resin 14 and the corresponding base resin 15.
Andrews
Stephen P
SP
GlaxoSmithKline Cambridge Technology Center, University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK.
Ladlow
Mark
M