Angiotensin-converting enzyme insertion/deletion genotype is associated with the activities of plasma coagulation factor VII and X independent of triglyceride metabolism.
BACKGROUND
The D allele of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and coagulation activity play important roles in cardiovascular events, however, the precise association between these two risk factors remains unclear.


METHODS
We identified the ACE I/D genotype and measured the plasma coagulation factor VII and X (FVII and FX) activities and serum lipids in 172 patients (110 men and 62 women, mean age 56.7+/-13.3 years) undergoing coronary angiography.


RESULTS
The frequency of the D allele was significantly higher in those with a history of myocardial infarction (MI) than in those with normal coronary arteries, but there was no significant association between FVII and FX activities and the stage of coronary disease. Plasma coagulation factor VII and FX activities were significantly lower in the DD genotype (n=42) than in the II genotype (n=67, P<0.001 and P<0.001, respectively) or the ID genotype (n=63, P<0.01 and P<0.05, respectively). The association of the ACE D allele with lower activities of FVII and FX was also seen in patients with coronary artery disease (CAD). There was a significant association between serum triglyceride levels with FVII and FX, but not with the ACE I/D genotype.


CONCLUSIONS
We concluded that the ACE I/D polymorphism may contribute more to the onset of MI than the activities of FVII and FX and that the ACE D allele might be associated with lower plasma activities of FVII and FX. The potential link between ACE I/D polymorphism and the plasma activities of FVII and FX is probably independent of triglyceride metabolism.
Okura
Yoshifumi
Y
Division of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Hayashi
Kozo
K
Shingu
Tetsuji
T
Kuga
Yoshio
Y
Nomura
Shuichi
S
Kajiyama
Goro
G
Nakashima
Yoshiyuki
Y
Saku
Keijiro
K
D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood / Q000201:enzymology*; D005167:Factor VII / Q000235:genetics*; D005170:Factor X / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000378:metabolism*
D008055:Lipids; D014280:Triglycerides; D005167:Factor VII; D005170:Factor X; D007703:Peptidyl-Dipeptidase A