Synthetic study of guanofosfocin. Synthesis of 8-(mannopyranosyloxy)inosine derivative.
As a basic study directed towards the synthesis of guanofosfocin analogues, preparation of a new class of nucleoside-carbohydrate hybrid has been investigated by two approaches; (1) glycosylation of 8-oxoinosine derivatives with mannopyranosyl bromide and (2) Mitsunobu reaction of 8-oxoinosine derivatives with protected mannopyranoses.
Kiyohara
W
W
Faculty of Education, Yokohama National University, Tokiwadai 79-2, Hodogaya-ku, Yokohama 240-8501, Japan.
Natsui
Y
Y
Koizumi
A
A
Sugimura
H
H
D002687:Chitin Synthase / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D006150:Guanine Nucleotides / Q000737:chemistry; D007288:Inosine / Q000031:analogs & derivatives*; D008358:Mannose / Q000737:chemistry; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D004791:Enzyme Inhibitors; D006150:Guanine Nucleotides; D011684:Purine Nucleosides; D007288:Inosine; D002687:Chitin Synthase; D008358:Mannose