title: The efficacy of omeprazole twice daily with supplemental H2 blockade at bedtime in the suppression of nocturnal oesophageal and gastric acidity.
abstract: BACKGROUND
  It has been presumed that nocturnal acid breakthrough may pose a risk for the development of nocturnal gastro-oesophageal reflux.
  
  
  OBJECTIVE
  To investigate the occurrence of gastro-oesophageal reflux and acid breakthrough during polygraphically monitored sleep under conditions of powerful acid suppression with omeprazole 20 mg b.d. and an additional dose of ranitidine at bedtime.
  
  
  METHODS
  Nineteen individuals with symptomatic gastro-oesophageal reflux disease were studied. Each individual was studied on two occasions subsequent to 1 week of 20 mg of omeprazole treatment b.d. Subjects underwent 24-h oesophageal and gastric pH recording, with polysomnographic monitoring. Participants received either 150 mg ranitidine at bedtime or placebo, prior to a provocative meal.
  
  
  RESULTS
  Ranitidine administration resulted in a significant (P < 0.01) reduction in the percentage of time the intragastric pH < 4.0. There was no significant difference with regard to measures of gastro-oesophageal reflux, and reflux events were not noted to occur with a significantly greater frequency during periods of nocturnal acid breakthrough compared with control intervals without acid breakthrough.
  
  
  CONCLUSIONS
  The administration of 150 mg ranitidine at bedtime did not significantly alter the occurrence of sleep-related gastro-oesophageal reflux.
authors.affiliation: Lynn Institute for Healthcare Research, Oklahoma City, OK , USA. worr@lhsi.net
authors.forename: W C
authors.initials: WC
authors.lastname: Orr
authors.forename: M J
authors.initials: MJ
authors.lastname: Harnish
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D002940:Circadian Rhythm; D004359:Drug Therapy, Combination; D004947:Esophagus / Q000502:physiology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000503:physiopathology; D006635:Histamine H2 Antagonists / Q000008:administration & dosage*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage*
chemical_list: D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D009853:Omeprazole