title: Evidence-based prevention (EBP): approach to lung cancer prevention based on cytochrome 1A1 and cytochrome 2E1 polymorphism.
abstract: Now that the human genome has been sequenced, we consider that combinations of 3 to 10 million polymorphic loci scattered throughout the genome contribute to individual differences. Genetic polymorphism analysis is useful for the made-to-order medical treatment of patients and the prevention of disease onset in normal healthy individuals. Individually-tailored disease prevention based on findings such as genetic polymorphism analysis results can be grasped by the concept of evidence-based prevention (EBP). In this paper we outline cytochrome P450 (CYP) 1A1 and 2E1 polymorphism-related differences in metabolic activation of carcinogens in relation to the risk of lung cancer, and explain single nucleotide polymorphism (SNP). We also compare the reports to date on SNP types in CYP1A1 and CYP2E1 in relation to the risk of lung cancer with our study results, examine survival rates of lung cancer patients by CYP1A1 or CYP2E1 genotype and discuss the applicability of SNP research to EBP.
authors.affiliation: Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
authors.forename: Tsunehiro
authors.initials: T
authors.lastname: Oyama
authors.forename: Akiko
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Toyohi
authors.initials: T
authors.lastname: Isse
authors.forename: Yong-Dae
authors.initials: YD
authors.lastname: Kim
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ozaki
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Osaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugio
authors.forename: Kosei
authors.initials: K
authors.lastname: Yasumoto
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kawamoto
mesh_terms: D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics* / Q000378:metabolism; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics* / Q000378:metabolism; D019317:Evidence-Based Medicine / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000517:prevention & control*; D020641:Polymorphism, Single Nucleotide
chemical_list: D019392:Cytochrome P-450 CYP2E1; D019363:Cytochrome P-450 CYP1A1