Effect of extracellular and intracellular angiotensins on heart cell function; on the cardiac renin-angiotensin system.
In this manuscript, I presented up-to-date evidence that intracellular and extracellular angiotensins have an important regulatory effect on the processes of heart cell communication and inward calcium current and that aldosterone modulates the effect of angiotensin II (Ang II) on the electrical properties of the heart. Moreover, I discussed the most relevant information about the origin of cardiac renin, the presence of a cardiac renin-angiotensin aldosterone system and its possible relevance for heart cell physiology and pathology.
De Mello
Walmor
W
Department of Pharmacology, School of Medicine, Medical Sciences Campus, UPR, PO Box 365067, San Juan, PR 00936-5067, USA. wmello@rcm.upr.edu
D000450:Aldosterone / Q000502:physiology; D000809:Angiotensins / Q000502:physiology*; D000818:Animals; D006801:Humans; D009206:Myocardium / Q000166:cytology*; D012084:Renin-Angiotensin System / Q000502:physiology*
D000809:Angiotensins; D000450:Aldosterone