title: Atomoxetine: a selective noradrenaline reuptake inhibitor for the treatment of attention-deficit/hyperactivity disorder.
abstract: Atomoxetine (Strattera, Eli Lilly & Co.) is a selective noradrenaline reuptake inhibitor that has been studied for use in the treatment of attention-deficit/hyperactivity disorder (ADHD). So far, two open-label and seven randomised, double-blind, placebo-controlled, clinical trials have been published, six in youths and three in adults. Each of these trials has shown a positive response as measured by the primary efficacy measures, the ADHD-IV Rating Scale (ADHD RS) or the Conners Adult ADHD Rating Scale (CAARS). Atomoxetine has generally been well tolerated. In November of 2002 the FDA approved atomoxetine for use in the US for the treatment of ADHD in children, adolescents and adults. Atomoxetine is the first nonstimulant approved by the FDA for the treatment of ADHD and the first medication approved for the treatment of adult ADHD.
authors.affiliation: Department of Psychiatry, University of Nebraska Medical Center, Omaha 68191-5581, USA. ckratoch@unmc.edu
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Kratochvil
authors.forename: Brigette S
authors.initials: BS
authors.lastname: Vaughan
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Harrington
authors.forename: William J
authors.initials: WJ
authors.lastname: Burke
mesh_terms: D000042:Absorption; D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D000069445:Atomoxetine Hydrochloride; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D002648:Child; D002986:Clinical Trials as Topic; D006207:Half-Life; D006801:Humans; D011437:Propylamines / Q000378:metabolism / Q000493:pharmacokinetics / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D011437:Propylamines; D000069445:Atomoxetine Hydrochloride