[Identification of migrants from nitrile-butadiene rubber gloves].
Polyvinyl chloride gloves containing di(2-ethylhexyl) phthalate are restricted for food contact use. In their place, disposable gloves made from nitrile-butadiene rubber (NBR) are used in contact with foodstuffs. Some unknown substances were found to migrate into n-heptane from NBR gloves. By GC/MS, HR-MS and NMR, their chemical structures were confirmed to be 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (used as a plasticizer), 4,4'-butylidenedi(6-tert-butyl-m-cresol), a mixture of styrenated phenols consisting of 2-(alpha-methylbenzyl)phenol, 4-(alpha-methylbenzyl)phenol, 2,6-di(alpha-methylbenzyl)phenol, 2,4-di(alpha-methylbenzyl)phenol and 2,4,6-tri(alpha-methylbenzyl)phenol (used as antioxidants), and 2,4-di-tert-butylphenol, which seems to a degradation product of antioxidant. Migration levels of these compounds were 1.68 micrograms/cm2 of 2,4-di-tert-butylphenol, 2.80 micrograms/cm2 of 2,2,4-trimethyl-1,3-pentanediol diisobutyrate, 46.08 micrograms/cm2 of styrenated phenols and 4.22 micrograms/cm2 of 4,4'-butylidenedi(6-tert-butyl-m-cresol) into n-heptane, respectively. The content of total styrenated phenols was 6,900 micrograms/g in NBR gloves.
Mutsuga
Motoh
M
National Institute of Health Sciences: 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Kawamura
Yoko
Y
Wakui
Chiseko
C
Maitani
Tamio
T
D000975:Antioxidants / Q000032:analysis; D004209:Disposable Equipment; D020724:Elastomers; D005506:Food Contamination / Q000032:analysis; D005511:Food Handling / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry; D017575:Gloves, Protective; D006018:Glycols / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D010636:Phenols / Q000032:analysis; D010968:Plasticizers / Q000032:analysis; D012408:Rubber / Q000032:analysis*
D000975:Antioxidants; D020724:Elastomers; D006018:Glycols; D010636:Phenols; D010968:Plasticizers; C086285:nitrile butyl rubber; C001508:2,2,4-trimethyl-1,3-pentanediol diisobutyrate; D012408:Rubber; C056559:2,4-di-tert-butylphenol