title: Stevens-Johnson syndrome in a boy with nephrotic syndrome during prednisolone therapy.
abstract: Stevens-Johnson syndrome (SJS) is a mucocutaneous disease that can be lethal. It can occur in association with altered immunological conditions and the administration of various drugs, including corticosteroids. We report a case of SJS in a 14-year-old male with nephrotic syndrome, who was treated with oral prednisolone for 6 weeks. He presented symptoms of fever, skin lesions consisting of multiple vesiculopapular rashes, pruritic maculae and bullae, and mucosal involvement of the eyes, lips, oral cavity, and anorectal junction. His condition improved without complications following the discontinuation of oral prednisolone and replacement with intravenous methylprednisolone. Following the improvement of the symptoms of SJS, he received alternate-day oral prednisolone without any cutaneous eruption.
authors.affiliation: Department of Pediatrics, Chonbuk National University Medical School, 634-18 Keumam-dong, Jeonju 561-712, Korea.
authors.forename: Dae Sun
authors.initials: DS
authors.lastname: Jo
authors.forename: Jun-Won
authors.initials: JW
authors.lastname: Yang
authors.forename: Pyoung Han
authors.initials: PH
authors.lastname: Hwang
authors.forename: Dae-Yeol
authors.initials: DY
authors.lastname: Lee
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D009404:Nephrotic Syndrome / Q000150:complications* / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000209:etiology
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone; D008775:Methylprednisolone