title: Effects of antidepressant drugs and GR 205171, an neurokinin-1 (NK1) receptor antagonist, on the response in the forced swim test and on monoamine extracellular levels in the frontal cortex of the mouse.
abstract: We tested fluoxetine, bupropion and GR 205171, a selective neurokinin-1 receptor antagonist on forced swimming test (FST) response and on levels of monoamines in frontal cortex of CD1 mice by microdialysis techniques. All drugs decreased immobility time. Fluoxetine augmented all monoamines, bupropion enhanced catecholamines, and GR 205171 was totally ineffective. Results suggest that FST response may not be related to levels of monoamines in the mouse frontal cortex.
authors.affiliation: GlaxoSmithKline, Psychiatry Centre of Excellence for Drug Discovery, Via Fleming 4, 37100 Verona, Italy. alessandro.a.zocchi@gsk.com
authors.forename: Alessandro
authors.initials: A
authors.lastname: Zocchi
authors.forename: Giorgia
authors.initials: G
authors.lastname: Varnier
authors.forename: Roberto
authors.initials: R
authors.lastname: Arban
authors.forename: Cristiana
authors.initials: C
authors.lastname: Griffante
authors.forename: Lara
authors.initials: L
authors.lastname: Zanetti
authors.forename: Letizia
authors.initials: L
authors.lastname: Bettelini
authors.forename: Mario
authors.initials: M
authors.lastname: Marchi
authors.forename: Philip A
authors.initials: PA
authors.lastname: Gerrard
authors.forename: Mauro
authors.initials: M
authors.lastname: Corsi
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D015306:Biogenic Monoamines / Q000378:metabolism*; D016642:Bupropion / Q000494:pharmacology; D005110:Extracellular Space / Q000187:drug effects / Q000378:metabolism; D005473:Fluoxetine / Q000494:pharmacology; D007103:Immobilization; D051379:Mice; D008815:Mice, Inbred Strains; D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines / Q000494:pharmacology*; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000378:metabolism; D013550:Swimming; D013777:Tetrazoles / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D015306:Biogenic Monoamines; D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines; D013777:Tetrazoles; D005473:Fluoxetine; D016642:Bupropion; C103207:vofopitant