title: Circulating antioxidants and lipid peroxidation products in untreated tuberculosis patients in Ethiopia.
abstract: BACKGROUND
  Knowledge of the antioxidant profile and its relation to lipid peroxidation in tuberculosis patients with or without accompanying HIV infection is scarce, particularly in developing countries.
  
  
  OBJECTIVE
  The objective was to further investigate the interaction between HIV, tuberculosis, and antioxidants and their relations with markers of oxidative stress in a large population of Ethiopians.
  
  
  METHODS
  In a cross-sectional study, we evaluated antioxidants and markers of oxidative stress in Ethiopian tuberculosis patients with (n = 25) and without (n = 100) HIV infection and in Ethiopian (n = 45) and Norwegian (n = 25) healthy control subjects.
  
  
  RESULTS
  Concentrations of the antioxidant vitamins C and E and of vitamin A were significantly lower in tuberculosis patients than in healthy Ethiopians. Tuberculosis patients also had significantly lower thiol concentrations, particularly of the reduced forms. Tuberculosis patients, particularly those who were co-infected with HIV, had higher malondialdehyde concentrations than did control subjects. High malondialdehyde concentrations were associated with clinical severity as measured by the Karnofsky Performance Status Index and anthropometric scores. Ethiopian control subjects had lower concentrations of vitamin E and higher concentrations of malondialdehyde than did Norwegian control subjects.
  
  
  CONCLUSIONS
  Our findings further support a link between oxidative stress, tuberculosis, and HIV infection. However, whether antioxidant supplementation will improve tuberculosis outcome or is of importance for its prevention should be further examined in future prospective studies.
authors.affiliation: Center for International Health, University of Bergen, Bergen, Norway. tesfaye.madebo@cih.uib.no
authors.forename: Tesfaye
authors.initials: T
authors.lastname: Madebo
authors.forename: Bernt
authors.initials: B
authors.lastname: Lindtjørn
authors.forename: Pål
authors.initials: P
authors.lastname: Aukrust
authors.forename: Rolf K
authors.initials: RK
authors.lastname: Berge
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D001782:Blood Donors; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005002:Ethiopia; D005260:Female; D006801:Humans; D017567:Karnofsky Performance Status; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009664:Norway; D009752:Nutritional Status; D018384:Oxidative Stress; D014376:Tuberculosis / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D014801:Vitamin A; D014810:Vitamin E; D008315:Malondialdehyde; D001205:Ascorbic Acid