title: Caveolin: a key target for modulating nitric oxide availability in health and disease.
abstract: The endothelial layer is a key component of the cardiovascular system. Recent evidence indicates that strategies aimed at preserving the endothelium may have important implications in the battle against cardiovascular disease. Nitric oxide remains the critical factor determinant of endothelial function. Understanding the regulatory components involved in nitric oxide production may elucidate novel targets for improving compromised vascular function. The caveolae/caveolin system has recently become of interest due to its ability to regulate endothelial nitric oxide synthase activity. The caveolae/caveolin system is a multifaceted structure in the plasma membrane, which plays an integral role in cellular signaling. Recognizing the potential of this specialized domain may provide the fundamental knowledge to target the endothelium in disease.
authors.affiliation: Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, ON, Canada.
authors.forename: Bikramjit
authors.initials: B
authors.lastname: Dhillon
authors.forename: Mitesh V
authors.initials: MV
authors.lastname: Badiwala
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Ren-Ke
authors.initials: RK
authors.lastname: Li
authors.forename: Richard D
authors.initials: RD
authors.lastname: Weisel
authors.forename: Donald A G
authors.initials: DA
authors.lastname: Mickle
authors.forename: Paul W M
authors.initials: PW
authors.lastname: Fedak
authors.forename: Vivek
authors.initials: V
authors.lastname: Rao
authors.forename: Subodh
authors.initials: S
authors.lastname: Verma
mesh_terms: D000818:Animals; D001682:Biological Availability; D002118:Calcium / Q000378:metabolism; D021941:Caveolae / Q000473:pathology / Q000502:physiology; D051242:Caveolin 1; D022461:Caveolins / Q000502:physiology*; D006262:Health; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism* / Q000493:pharmacokinetics*; D010766:Phosphorylation; D015398:Signal Transduction
chemical_list: C495540:CAV1 protein, human; D051242:Caveolin 1; D022461:Caveolins; D018832:Molecular Chaperones; D009569:Nitric Oxide; D002118:Calcium