Eber- and LMP-1-expressing pulmonary lymphoepithelioma-like carcinoma in a Caucasian patient.
Primary lymphoepithelioma-like carcinoma (LELC) of the lung is a rare tumor that preferentially affects Asian patients, with only 15 cases described in Caucasians to date. Epstein-Barr virus (EBV) infection is present in most lung LELCs in Asians, but it has never been shown in Caucasians. EBV small nuclear RNA and latent membrane protein-1 were identified in the neoplastic cells of primary LELC of the lung diagnosed by endobronchial biopsy in a 25-year-old Italian male. Despite advanced locoregional disease, with neoplastic infiltration of the main right bronchus, the carina, and the pulmonary artery, which prevented surgical resection, partial response and 1-year symptom-free follow-up were achieved after combined chemotherapy and radiotherapy.
Morbini
Patrizia
P
Department of Pathology, IRCCS Policlinico S. Matteo, Pavia, Italy.
Riboni
Roberta
R
Tomaselli
Stefano
S
Rossi
Albino
A
Magrini
Umberto
U
D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000556:secondary / Q000628:therapy / Q000821:virology; D002467:Cell Nucleus / Q000378:metabolism / Q000473:pathology / Q000821:virology; D003131:Combined Modality Therapy; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy / Q000821:virology; D008297:Male; D009367:Neoplasm Staging; D010166:Palliative Care; D016601:RNA-Binding Proteins / Q000378:metabolism*; D011878:Radiotherapy; D012269:Ribosomal Proteins; D016896:Treatment Outcome; D014763:Viral Matrix Proteins / Q000378:metabolism*
D000956:Antigens, Viral; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; D014763:Viral Matrix Proteins; C067169:RPL22 protein, human