Emi1 proteolysis: how SCF(beta-Trcp1) helps to activate the anaphase-promoting complex.
Emi1 inhibits the anaphase-promoting complex (APC) during S and G2 phase. Two papers by Guardavaccaro et al. and Margottin-Goguet et al. in the June issue of Developmental Cell now show that Emi1 degradation in early mitosis is mediated by beta-Trcp1, an adaptor protein that recruits proteins to the SCF ubiquitin ligase.
Peters
Jan-Michael
JM
Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, 1030 Vienna, Austria.
D020816:Amino Acid Motifs; D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism*; D004330:Drosophila; D016195:G2 Phase; D019204:GTP-Binding Proteins / Q000378:metabolism*; D008025:Ligases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010766:Phosphorylation; D016196:S Phase; D043743:Ubiquitin-Protein Ligase Complexes; D014981:Xenopus; D029867:Xenopus Proteins; D044844:beta-Transducin Repeat-Containing Proteins
C471646:BTRC protein, Xenopus; D018797:Cell Cycle Proteins; C429107:FBXO5 protein, Xenopus; D029867:Xenopus Proteins; D044844:beta-Transducin Repeat-Containing Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D016203:CDC2 Protein Kinase; D019204:GTP-Binding Proteins; D008025:Ligases