[Retroviral long terminal repeats: structure and function].
Characteristic genetic sequences, named as LTR, are present at the end of retroviral genomes. They are involved in the integration of viral nucleic acid into chromosomes of cell host. In addition, LTR modulates the transcription of retroviral genes and, in this form, determine their virulence. LTR from distinct HIV-1 subtypes show structural differences which may result in distinct biological behaviors and, ultimately, different disease progression.
Lospitao
Eva
E
Laboratorio de Biología Molecular. Servicio de Enfermedades Infecciosas. Hospital Carlos III. Madrid. España.
Holguín
Africa
A
Soriano
Vicente
V
D016679:Genome, Viral; D016325:HIV Long Terminal Repeat / Q000502:physiology*; D006801:Humans; D012190:Retroviridae / Q000235:genetics*