Novel 12-membered ring macrolides with activity against erythromycin-resistant organisms.
A series of novel 12-membered ring macrolides was designed based on available information on structure-activity relationships and macrolide-ribosome interactions. Compounds with the desosamine and the anchor group properly attached to the 12-membered lactone ring exhibited improved activity against erythromycin-resistant organisms.
Nemoto
Peter A
PA
Infectious Disease Research, Abbott Laboratories, 200 Abbott Park Rd., Abbott Park, IL 60064-6217, USA.
Zhang
Xiaolin
X
Djuric
Stevan
S
Ma
Zhenkun
Z
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D006193:Haemophilus influenzae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects
D000900:Anti-Bacterial Agents; D004917:Erythromycin