Synthesis and antibacterial activity of oxazolidinone containing sulphonyl group.
A series of oxazolidinone derivatives carrying sulphonyl group was synthesized and their antibacterial activity was evaluated in vitro. Many of such compounds demonstrated potent antibacterial activity. The activity of a novel compound (YC-20) was 2-4-fold more potent than that of linezolid.
Cui
Yingjie
Y
Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences, 200031, Shanghai, China.
Yang
Yushe
Y
Chen
Kaixian
K
Ji
Ruyun
R
Zhang
Shuhua
S
D000081:Acetamides / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006094:Gram-Positive Bacteria / Q000187:drug effects; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D023303:Oxazolidinones / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*
D000081:Acetamides; D000890:Anti-Infective Agents; D010080:Oxazoles; D023303:Oxazolidinones; D013449:Sulfonamides; D000069349:Linezolid