Pathophysiologic characteristics of the activity-stress paradigm in animal models: inhibitory effect of glucose on these responses.
This review provides a discussion of the pathophysiologic significance of animal models of the activity-stress paradigm and the role of plasma glucose level in the appearance of physical stress responses of those models. Many research reports have demonstrated that animal models exposed to activity-stress are useful as a "symptomatic model" of anorexia nervosa and obsessive-compulsive disorder as well as peptic ulcer. Our findings show that a decrease in plasma glucose concentration is an important factor in determining the activity-stress-induced physical responses. Further investigation of the pathophysiology of activity-stressed animal models may contribute to the development of new therapeutics for diseases such as anorexia nervosa and obsessive-compulsive disorder.
Takeda
Hiroshi
H
Department of Pharmacology and Intractable Diseases Research Center, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan.
Tsuji
Minoru
M
Hayashi
Masaaki
M
Yamada
Tomoko
T
Matsumiya
Teruhiko
T
Koizumi
Miwako
M
Kimura
Shuichi
S
D000818:Animals; D000856:Anorexia Nervosa; D001786:Blood Glucose / Q000032:analysis*; D004195:Disease Models, Animal; D005508:Food Deprivation; D005947:Glucose / Q000008:administration & dosage; D009771:Obsessive-Compulsive Disorder; D005082:Physical Exertion; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology*
D001786:Blood Glucose; D005947:Glucose