title: Lead compounds discovered from libraries: part 2.
abstract: Many lead compounds with the potential to progress to viable drug candidates have been identified from libraries during the past two years. There are two key strategies most often employed to find leads from libraries: first, high-throughput biological screening of corporate compound collections; and second, synthesis and screening of project-directed libraries (i.e. target-based libraries). Numerous success stories, including the discovery of several clinical candidates, testify to the utility of chemical library collections as proven sources of new leads for drug development.
authors.affiliation: Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040-8006, USA. golebiowski.a@pg.com
authors.forename: Adam
authors.initials: A
authors.lastname: Golebiowski
authors.forename: Sean R
authors.initials: SR
authors.lastname: Klopfenstein
authors.forename: David E
authors.initials: DE
authors.lastname: Portlock
mesh_terms: D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000639:trends*; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D019151:Peptide Library
chemical_list: D019151:Peptide Library