Lead compounds discovered from libraries: part 2.
Many lead compounds with the potential to progress to viable drug candidates have been identified from libraries during the past two years. There are two key strategies most often employed to find leads from libraries: first, high-throughput biological screening of corporate compound collections; and second, synthesis and screening of project-directed libraries (i.e. target-based libraries). Numerous success stories, including the discovery of several clinical candidates, testify to the utility of chemical library collections as proven sources of new leads for drug development.
Golebiowski
Adam
A
Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040-8006, USA. golebiowski.a@pg.com
Klopfenstein
Sean R
SR
Portlock
David E
DE
D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000639:trends*; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D019151:Peptide Library
D019151:Peptide Library