title: [Chickenpox outbreak in Herrera del Duque, Badajoz, Spain].
abstract: BACKGROUND
  Chickenpox is a worldwide disease with high morbidity but few complications, although complications can be sevre in immunocompromised individuals and healthy adults. The annual chickenpox rate declared to the National Notification Disease Surveillance System is approximately 5 cases per 1,000 inhabitants in Extremadura (Spain). The aim of this study was to identify and describe the characteristics and cost of an epidemic outbreak of chickenpox in Extremadura.
  
  
  METHODS
  Between November 2000 and March 2001, a descriptive study was performed. Cases of chickenpox were actively sought in a cohort of schoolchildren in Herrera del Duque (Badajoz). The protocols of the Monitoring Network of the Autonomous Community of Extremadura was used for case definition. Microbiological confirmation was performed by isolation of the virus and the presence of IgM and IgG markers in serum. We analyzed the direct and indirect tangible costs as well as the intangible costs of the outbreak.
  
  
  RESULTS
  Seventy-five cases were identified, of which 94.7% occurred in children aged between 1-9 years, mainly boys. The attack rate was 18.5 cases per 1,000 inhabitants and 68.2% occurred in children aged less than 10 years charing a home. The clinical course was benign, without hospital admissions or complications. A total of 71.6% of children aged between 3 and 8 years were susceptible. A possible temporary aggregation of cases in the school was analyzed and a relative risk of 5.01 (p < 0.0001) was obtained. The virus was isolated in the 4 vesicle samples studied and serology was positive (IgM) in the 9 serum samples studied. The total cost of the outbreak was of 927,21 e, with a mean of 12,53 e per case and 205 school days lost.
  
  
  CONCLUSIONS
  A chickenpox outbreack was confirmed in Herrera del Duque, with person-to-person transmission, affecting children aged between 1 and 9 years. The high susceptibility of the pupils, the characteristics of teaching, and the meetings prior to the carnivals played a determining role in the transmission of the epidemic. The estimated cost of this outbreak was 76% less than the cost that would have been generated by single-dose vaccination of the 75 individuals who contracted the disease.
authors.affiliation: Programa de Epidemiología Aplicada de Campo. Centro Nacional de Epidemiología. Madrid, Spain. fvalades@isciii.es
authors.forename: F J
authors.initials: FJ
authors.lastname: Valadés
authors.forename: A
authors.initials: A
authors.lastname: Barrasa
authors.forename: E
authors.initials: E
authors.lastname: Peña
authors.forename: J F
authors.initials: JF
authors.lastname: Sánchez
authors.forename: C
authors.initials: C
authors.lastname: Amela
authors.forename: I
authors.initials: I
authors.lastname: Pachón
authors.forename: D
authors.initials: D
authors.lastname: Herrera
authors.forename: F
authors.initials: F
authors.lastname: Martínez-Navarro
authors.forename: J M
authors.initials: JM
authors.lastname: Ramos
mesh_terms: D002644:Chickenpox / Q000191:economics / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D013030:Spain / Q000453:epidemiology; D014611:Vaccination / Q000191:economics