[Morphogens and endocytosis].
During development, secreted signaling proteins of the Wingless/Wnt, Hedgehog and Decapentaplegic (Dpp)/Bone Morphogenic Protein (BMP) families act as morphogens. Previous work had shown that these molecules act directly on distant cells, although until recently nothing was known about how they reach those distant cells. During the past two years, work carried out on Drosophila using genetic and cell biology approaches have revealed that endocytosis plays a central part in the mechanisms that control the spread of morphogens.
Dubois
Laurence
L
Centre de Biologie du Développement, Université Paul Sabatier, Bâtiment IVR3, 118, route de Narbonne, 31062 Toulouse, France. dubois@cict.fr
D000818:Animals; D004330:Drosophila / Q000196:embryology* / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics / Q000494:pharmacology*; D004705:Endocytosis / Q000502:physiology*; D053823:Hedgehog Proteins; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000494:pharmacology*; D015398:Signal Transduction; D051155:Wnt1 Protein
D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D011518:Proto-Oncogene Proteins; D051155:Wnt1 Protein; C064196:dpp protein, Drosophila; C074622:wg protein, Drosophila; C077245:hh protein, Drosophila