title: Aggressive, multifocal oral verrucous leukoplakia: proliferative verrucous leukoplakia or not?
abstract: BACKGROUND
  Some oral verrucal lesions may constitute parts of the clinicopathological spectrum of proliferative verrucous leukoplakia (PVL). Because of its idiopathic yet sinister nature, it is possible that PVL may exist in other populations. The aim of this study was to review the clinicopathological features of persistent, multifocal, oral verrucal lesions in Malaysian population.
  
  
  METHODS
  Patients with multifocal oral verrucal lesions were selected from surgical and histopathological records.
  
  
  RESULTS
  Nine patients of diverse ethnicity with 43 biopsies were reviewed. The mean age at the presentation was 62 years. The most frequent sites affected were gum, sulci, cheek and tongue. Indulgence in risk habits was reported in about 70% of patients. Four cases developed multifocal carcinoma from multifocal leukoplakia.
  
  
  CONCLUSIONS
  In retrospect, none of the cases fulfilled the original PVL criteria, although three cases were suggestive of PVL. Nevertheless, these findings do not necessarily preclude the existence of PVL as a clinicopathological entity in Malaysian population.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
authors.forename: Naseem
authors.initials: N
authors.lastname: Ghazali
authors.forename: Marina Mohd
authors.initials: MM
authors.lastname: Bakri
authors.forename: Rosnah Binti
authors.initials: RB
authors.lastname: Zain
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D018289:Carcinoma, Verrucous / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005006:Ethnicity; D005260:Female; D005887:Gingival Neoplasms / Q000145:classification; D006801:Humans; D007972:Leukoplakia, Oral / Q000145:classification* / Q000473:pathology; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000145:classification / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000145:classification* / Q000473:pathology; D012307:Risk Factors; D014062:Tongue Neoplasms / Q000145:classification; D014860:Warts / Q000145:classification / Q000473:pathology