Effects of undernutrition on glutamatergic parameters in rat brain.
Early restriction of nutrients during the perinatal period has marked repercussions on CNS ontogeny, leading to impaired functions. This study investigated the effects of pre- and postnatal (up to 75 days) undernutrition (diet: 8% protein; normonourished group: 25% protein) on some glutamatergic and behavioral parameters of rats. Undernutrition reduced: (i) seizures caused by ICV quinolinic acid (QA) administration; (ii) Na-independent [3H]glutamate binding in cell plasma membranes of cerebral cortex, and (ii) basal [3H]glutamate release from synaptosomal preparation. Behavioral parameters related to locomotion, anxiety, or memory were not affected. These results indicate that our model of undernutrition decreased the sensitivity to QA as convulsing agent and point to some putative glutamatergic parameters involved in this effect.
Rotta
Liane N
LN
Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90035-003, Porto Alegre, RS, Brazil.
Schmidt
André P
AP
Mello e Souza
Tadeu
T
Nogueira
Cristina W
CW
Souza
Karine B
KB
Izquierdo
Ivan A
IA
Perry
Marcos L S
ML
Souza
Diogo O
DO
D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D009748:Nutrition Disorders / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D018698:Glutamic Acid