title: Protein kinase D: a family affair.
abstract: The protein kinase D family of enzymes consists of three isoforms: PKD1/PKCmu PKD2 and PKD3/PKCnu. They all share a similar architecture with regulatory sub-domains that play specific roles in the activation, translocation and function of the enzymes. The PKD enzymes have recently been implicated in very diverse cellular functions, including Golgi organization and plasma membrane directed transport, metastasis, immune responses, apoptosis and cell proliferation.
authors.affiliation: Division of Biochemistry, Faculty of Medicine, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium.
authors.forename: An
authors.initials: A
authors.lastname: Rykx
authors.forename: Line
authors.initials: L
authors.lastname: De Kimpe
authors.forename: Svetlana
authors.initials: S
authors.lastname: Mikhalap
authors.forename: Tibor
authors.initials: T
authors.lastname: Vantus
authors.forename: Thomas
authors.initials: T
authors.lastname: Seufferlein
authors.forename: Jackie R
authors.initials: JR
authors.lastname: Vandenheede
authors.forename: Johan
authors.initials: J
authors.lastname: Van Lint
mesh_terms: D000818:Animals; D017209:Apoptosis; D001692:Biological Transport; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D004789:Enzyme Activation; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D011493:Protein Kinase C / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D007527:Isoenzymes; C089212:protein kinase D; D011493:Protein Kinase C