Bone marrow precursor of extranodal T-cell lymphoma.
The development of extranodal lymphomas is thought to be initiated by the transformation event in peripheral organs. Lymphomatoid papulosis (LyP) is a low-grade cutaneous lymphoma and may progress into the cutaneous anaplastic lymphoma. We identified 2 patients who 3 and 4 years before the development of LyP were treated for an unrelated malignancy (Burkitt lymphoma and small-cell B-cell lymphoma). We analyzed the T-cell receptor (TCR) gene rearrangement pattern in their skin, blood, and bone marrow, including the archival bone marrow sampled years before the development of clinically evident LyP. In all samples we detected the unique monoclonal TCR rearrangements. This observation suggests that the initial malignant transformation in LyP occurred in bone marrow and not, as could be supposed, in the skin.
Gniadecki
Robert
R
Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, Bldg D42, Bispebjerg bakke 23, DK-2400 Copenhagen, Denmark. rg01@bbh.hosp.dk
Lukowsky
Ansgar
A
Rossen
Kristian
K
Madsen
Hans O
HO
Thomsen
Kristian
K
Wulf
Hans Christian
HC
D000328:Adult; D001853:Bone Marrow / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells; D005260:Female; D015321:Gene Rearrangement; D019672:Genes, T-Cell Receptor; D006801:Humans; D017730:Ki-1 Antigen; D017728:Lymphoma, Large-Cell, Anaplastic / Q000209:etiology / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000209:etiology / Q000473:pathology*; D017731:Lymphomatoid Papulosis / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000473:pathology
D017730:Ki-1 Antigen