Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by beta-cyclodextrine modified capillary electrophoresis: a complementary method to GC-MS.
The chiral separation of (+/-)-methamphetamine, (+/-)-methcathinone, (+/-)-ephedrine and (+/-)-pseudoephedrine by means of beta-cyclodextrine modified capillary electrophoresis is described. The distribution of enantiomers in clandestine tablets and urine samples were identified. Several electrophoretic parameters such as the concentration of beta-cyclodextrin, temperature, the applied voltage and the amount of organic solvent required for successful separation were optimized. The method, as described herein, represents a good complementary method to GC-MS for use in forensic and clinical analysis.
Liau
An-Shu
AS
Department of Chemistry, National Taiwan Normal University, 88 Sec. 4, Tingchow Road, Taipei, Taiwan.
Liu
Ju-Tsung
JT
Lin
Li-Chan
LC
Chiu
Yu-Chih
YC
Shu
You-Ren
YR
Tsai
Chung-Chen
CC
Lin
Cheng-Huang
CH
D000697:Central Nervous System Stimulants / Q000737:chemistry / Q000302:isolation & purification / Q000652:urine; D003505:Cyclodextrins; D019075:Electrophoresis, Capillary / Q000379:methods*; D004809:Ephedrine / Q000737:chemistry / Q000302:isolation & purification / Q000652:urine; D005554:Forensic Medicine / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013287:Illicit Drugs / Q000737:chemistry*; D008694:Methamphetamine / Q000737:chemistry / Q000302:isolation & purification / Q000652:urine; D015394:Molecular Structure; D011427:Propiophenones / Q000737:chemistry / Q000302:isolation & purification / Q000652:urine; D013237:Stereoisomerism; D013607:Tablets
D000697:Central Nervous System Stimulants; D003505:Cyclodextrins; D013287:Illicit Drugs; D011427:Propiophenones; D013607:Tablets; C047806:monomethylpropion; D008694:Methamphetamine; D004809:Ephedrine