Chemical synthesis of uridine diphospho-D-xylose and UDP-L-arabinose.
Leloir transferases, like UDP-d-xylosyl transferase and arabinosyl transferase, utilize nucleoside diphosphate sugars to build up plant oligo- and polysaccharides. By the described, scalable three-step synthesis a simple route is described to arrive at the respective enzyme substrates, which are otherwise difficult to obtain.
Ernst
Christiane
C
Organisch-Chemisches Institut der Westfälischen Wilhelms-Universität, Corrensstrasse 40, D-48149 Münster, Germany.
Klaffke
Werner
W
D016695:Glycosyltransferases; D013379:Substrate Specificity; D014539:Uridine Diphosphate Sugars / Q000138:chemical synthesis*; D014540:Uridine Diphosphate Xylose / Q000138:chemical synthesis*
D014539:Uridine Diphosphate Sugars; C040817:uridine diphosphate arabinose; D014540:Uridine Diphosphate Xylose; D016695:Glycosyltransferases