Immunopathogenesis and immunotherapy in AIDS virus infections.
The heterogeneity of HIV and the different human leukocyte antigen (HLA) backgrounds of infected individuals have posed challenges to understanding the pathogenesis of HIV infection. But continuing advances in our knowledge of the role of immune responses in controlling HIV viremia should help to define goals for immune-based therapies and vaccine strategies against AIDS.
Letvin
Norman L
NL
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Walker
Bruce D
BD
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000628:therapy*; D000906:Antibodies / Q000276:immunology; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology* / Q000472:pathogenicity*; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000821:virology
D000906:Antibodies; D006680:HLA Antigens