Flow NMR applications in combinatorial chemistry.
Flow NMR techniques are now well accepted and widely used in many areas of drug discovery. Although natural-product-, rational-drug-design-, and NMR-screening-programs have begun to use flow NMR more routinely, flow NMR has not yet gained widespread acceptance in combinatorial chemistry, even though it has been shown to be a potentially useful tool. Recent developments in DI-NMR, FIA-NMR, and LC-NMR will help flow NMR eventually gain a wider acceptance within combinatorial chemistry. These developments include LC-NMR-MS instrumentation, flow probe improvements, new pulse sequences, improved automation of NMR data analysis, and the application of flow NMR to related fields in drug discovery.
Keifer
Paul A
PA
University of Nebraska Medical Center/Eppley Institute, 986805 Nebraska Medical Center, Omaha, NE 68198-6805, USA. pkeifer@unmc.edu
D000818:Animals; D002853:Chromatography, Liquid; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation / Q000379:methods*; D003627:Data Interpretation, Statistical; D017022:Flow Injection Analysis; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D012015:Reference Standards
D007202:Indicators and Reagents