title: Microbial degradation of illicit drugs, their precursors, and manufacturing by-products: implications for clandestine drug laboratory investigation and environmental assessment.
abstract: Chemicals associated with clandestine drug laboratories are often disposed of covertly into soil, sewerage systems, or public waste management facilities. There are two significant issues relating to such dumps of materials; they might contain valuable evidence as to drug manufacture, and they might be a source of pollution. This study presents initial findings in relation to the impact microorganisms from environmental sources have upon drugs, their precursors, and manufacturing by-products. The aim of this study was to identify which chemicals associated with clandestine drug laboratories persist in the environment in order to allow forensic drug chemists to link discarded residues with the method of manufacture, and to allow the environmental impact of clandestine drug laboratories to be assessed accurately. When exposed to soil microorganisms, phenyl-2-propanone (P2P) was rapidly metabolized into mixtures of 1-phenyl-2-propanol, 1-phenyl-1,2-propanedione, 1-hydroxy-1-phenyl-2-propanone, 2-hydroxy-1-phenyl-1-propanone, and the two diastereoisomers of 1-phenyl-1,2-propanediol. On the other hand, when exposed under the same conditions, methylamphetamine sulphate (MAS) remained virtually unchanged. Implications relating to evidence gathering for forensic purposes and to environmental assessment of clandestine drug laboratories are discussed.
authors.affiliation: School of Chemistry, Physics and Earth Sciences, Flinders University of South Australia, Bedford Park, Australia
authors.forename: A
authors.initials: A
authors.lastname: Janusz
authors.forename: K P
authors.initials: KP
authors.lastname: Kirkbride
authors.forename: T L
authors.initials: TL
authors.lastname: Scott
authors.forename: R
authors.initials: R
authors.lastname: Naidu
authors.forename: M V
authors.initials: MV
authors.lastname: Perkins
authors.forename: M
authors.initials: M
authors.lastname: Megharaj
mesh_terms: D019840:2-Propanol / Q000737:chemistry*; D000096:Acetone / Q000031:analogs & derivatives* / Q000737:chemistry*; D001673:Biodegradation, Environmental; D000697:Central Nervous System Stimulants / Q000737:chemistry*; D005554:Forensic Medicine / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D008694:Methamphetamine / Q000737:chemistry*; D012987:Soil / Q000032:analysis*; D012988:Soil Microbiology
chemical_list: D000697:Central Nervous System Stimulants; D012987:Soil; D000096:Acetone; D008694:Methamphetamine; C035293:1-hydroxy-1-phenyl-2-propanone; D019840:2-Propanol; C008863:1-phenyl-2-propanone