Structure and biological activity of some 4-amino-3-cinnolinecarboxylic acid derivatives. QSAR analysis of cinnoline derivatives with antibacterial properties.
QSAR analysis was done in a group of cinnoline-3-carboxylic acid derivatives with antibacterial properties. Several physicochemical parameters, which characterize the variability of the structure of the 15 studied compounds, were compared as to their activity against gram-positive cocci, gram-negative bacilli and gram-positive bacilli strains. The physicochemical parameters with predictive value were found.
Brzezińska
Elzbieta
E
Department of Analytical Chemistry, Medical University of Lódź, 1 Muszyńskiego Str., 90-151 Lódź, Poland.
Stańczak
Andrzej
A
Ochocki
Zbigniew
Z
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D006574:Heterocyclic Compounds, 2-Ring; D007202:Indicators and Reagents; D011804:Quinolines; C476282:cinnoline