title: Leiomyosarcoma of the bladder in a retinoblastoma patient.
abstract: We report a rare case of leiomyosarcoma in the bladder which occurred in an 18-year-old female with a prior history of retinoblastoma (RB). Molecular characterization of this tumor displayed a homozygous RB deletion and a reduced P53 expression. These results suggest that the loss of RB and P53 may have contributed to the initiation and/or progression of the leiomyosarcoma of the bladder in this patient.
authors.affiliation: Department of Surgery, Cross Cancer Institute, Edmonton, Alta., Canada.
authors.forename: Stacey L
authors.initials: SL
authors.lastname: Bléoo
authors.forename: Roseline
authors.initials: R
authors.lastname: Godbout
authors.forename: David
authors.initials: D
authors.lastname: Rayner
authors.forename: Yahya
authors.initials: Y
authors.lastname: Tamimi
authors.forename: Ronald B
authors.initials: RB
authors.lastname: Moore
mesh_terms: D000293:Adolescent; D003131:Combined Modality Therapy; D015653:Cystectomy; D005260:Female; D016161:Genes, Retinoblastoma / Q000235:genetics; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D007890:Leiomyosarcoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D019572:Retinal Neoplasms / Q000235:genetics* / Q000628:therapy; D012175:Retinoblastoma / Q000235:genetics* / Q000628:therapy; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery