Extrafollicular antibody responses.
In adaptive antibody responses, B cells are induced to grow either in follicles where they form germinal centers or in extrafollicular foci as plasmablasts. Extrafollicular growth typically occurs in the medullary cords of lymph nodes and in foci in the red pulp of the spleen. It is not a feature of secondary lymphoid tissue associated with the internal epithelia of the body. All types of naïve and memory B cells can be recruited into extrafollicular responses. These responses are associated with immunoglobulin class switching but, at the most, only low-level hypermutation.
MacLennan
Ian C M
IC
MRC Center for Immune Regulation, University of Birmingham, Birmingham, UK. i.c.m.maclennan@bham.ac.uk
Toellner
Kai-Michael
KM
Cunningham
Adam F
AF
Serre
Karine
K
Sze
Daniel M-Y
DM
Zúñiga
Elina
E
Cook
Matthew C
MC
Vinuesa
Carola G
CG
D000818:Animals; D000906:Antibodies / Q000235:genetics / Q000276:immunology*; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement
D000906:Antibodies