[Expression and significance of vascular permeability factor (VPF) in inflammatory cells of nasal polyps].
OBJECTIVE
To study the expression and significance of vascular permeability factor (VPF) in eosinophil, macrophage and plasma cell in nasal polyps.


METHODS
VPF in 12 nasal polyps was studied by immunohistochemistry, double immune-enzymatic staining technique and double MGG staining technique. Each section was observed under optical microscope.


RESULTS
Immunohistochemistry result: VPF was detected in the cells showing morphological feature of plasma cells. Double immune-enzymatic staining result: CD68 positive cells in the second staining conformed to VPF positive cells in the first staining. MGG and immune-enzymatic double staining result: eosinophils in MGG staining were in conformity with some VPF positive cells.


CONCLUSIONS
Positive expression of VPF in eosinophils, macrophages and plasma cells indicates that VPF may play a role in the formation of heavy edema of nasal polyps.
Yang
Jihong
J
Department of Otolaryngology, Second Affiliated Hospital, Wenzhou Medical College, Wenzhou 325027.
Dong
Zhen
Z
Gao
Jinjian
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D004804:Eosinophils / Q000378:metabolism*; D005260:Female; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*
D042461:Vascular Endothelial Growth Factor A