title: Association between simian virus 40 DNA and lymphoma in the United kingdom.
abstract: Recent studies have reported the presence of simian virus 40 (SV40) DNA sequences in approximately 40% of tumor samples from non-Hodgkin's lymphoma (NHL) patients from the United States. We examined a series of 259 tumor and blood samples, including 152 NHL samples, from patients in the U.K. with lymphadenopathy and lymphoid leukemia for the presence of SV40 DNA using a highly sensitive quantitative polymerase chain reaction (PCR) assay and a consensus PCR assay capable of detecting the polyomaviruses SV40, BK, and JC. SV40 DNA sequences were not detected in any sample using either assay. Because the incidence of NHL is similar in the U.K. and the United States, this finding suggests that SV40 is unlikely to have an etiologic role in NHL.
authors.affiliation: Leukaemia Research Fund Virus Centre, Institute of Comparative Medicine, University of Glasgow, Glasgow, UK.
authors.forename: Jane
authors.initials: J
authors.lastname: MacKenzie
authors.forename: Katherine S
authors.initials: KS
authors.lastname: Wilson
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Perry
authors.forename: Alice
authors.initials: A
authors.lastname: Gallagher
authors.forename: Ruth F
authors.initials: RF
authors.lastname: Jarrett
mesh_terms: D004279:DNA, Viral / Q000302:isolation & purification; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000821:virology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000821:virology; D008223:Lymphoma / Q000453:epidemiology / Q000821:virology*; D008228:Lymphoma, Non-Hodgkin / Q000821:virology; D016133:Polymerase Chain Reaction; D011120:Polyomavirus / Q000302:isolation & purification; D013539:Simian virus 40 / Q000235:genetics / Q000302:isolation & purification*; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D004279:DNA, Viral