Expression of heat shock protein (Hsp) 70 and Hsp 40 in colorectal cancer.
Heat shock protein (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. The present study was designed to determine the expression levels of Hsp 70 and Hsp 40 in colorectal cancer by immunohistochemistry and Western blot analysis. Among 50 colorectal cancer tissues studied, 80% and 14% of tumors showed specific immunoreactivity to Hsp 70 and Hsp 40, respectively. Hsp 70 and Hsp 40 were overexpressed in cancer tissue samples compared with normal tissues, on both analytic sets. However, there were no significant correlations between their expression and various clinicopathological parameters of colorectal cancer. Hsp 70 and Hsp 40 may be tumor markers for colorectal cancer.
Kanazawa
Yusei
Y
Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Isomoto
Hajime
H
Oka
Mikio
M
Yano
Yoshitsugu
Y
Soda
Hiroshi
H
Shikuwa
Saburo
S
Takeshima
Fuminao
F
Omagari
Katsuhisa
K
Mizuta
Yohei
Y
Murase
Kunihiko
K
Nakagoe
Toru
T
Ohtsuka
Kenzo
K
Kohno
Shigeru
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D015153:Blotting, Western; D015179:Colorectal Neoplasms / Q000378:metabolism*; D005260:Female; D050956:HSP40 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged
D014408:Biomarkers, Tumor; D050956:HSP40 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins