Local inhibition of chlorhexidinum on Lewis pulmonary carcinoma in mice.
C57 inbred mice (n = 100) were employed to develop animal models of Lewis pulmonary carcinoma. The study on the tumor inhibition was performed by infiltrative injection of 3.5% Cy or chlorhexidinum of two different concentrations around the tumor respectively. The survival, survival rate, tumor growth rate, and pulmonary metastasis node number were compared. The results showed that the inhibitory effects of 0.1% and 0.5% chlorhexidinum were the same as that of 3.5% Cy, but the toxic and side effects were obviously reduced as compared with 3.5% Cy. The optimal concentration of chlorhexidinum was 0.5%. This provides a new approach for infiltrative injection of the tumor for clinical use.
Xiong
J
J
Department of General Surgery, Xiehe Hospital, Tongji Medical University, Wuhan 430022.
Huang
T
T
Qiu
D
D
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000473:pathology*; D002710:Chlorhexidine / Q000008:administration & dosage / Q000494:pharmacology*; D008168:Lung / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D000970:Antineoplastic Agents; D002710:Chlorhexidine