Neurocytoma arising in the pelvis.
Central neurocytoma represents a rare neoplasm of the central nervous system with advanced neurocytic and sometimes focal lipomatous differentiation, a low proliferative potential and a favorable prognosis depending on the efficiency of surgical resection. This entity has been described as an intraventricular tumor near the foramen Monroi. Here, we report a case of a 21-year-old male with peripheral neurocytoma. Using computed tomography, a tumor of unknown origin was located behind the bladder. After complete surgical resection of the tumor, histologically small uniform cells, zones of fibrillarity and neuropil-like islands were seen. Immunohistochemistry revealed positivity for the neuronal markers synaptophysin, neuron-specific enolase and neurofilaments. Vimentin, pan-keratin, desmin, chromogranin, CD-99 and glial fibrillary acidic protein were immuno-negative. A low proliferation rate (1-2%) was found. Several case reports described extraventricular central neurocytomas. A sole publication documented a peripheral neurocytoma arising within a mature cystic teratoma of the ovary. To our knowledge, this is the second reported case of a neurocytoma outside the central nervous system, indicating that this entity may also occur infrequently in peripheral tissues.
Friedrichs
Nicolaus
N
Institute of Pathology, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.
Vorreuther
Roland
R
Fischer
Hans-Peter
HP
Wiestler
Otmar D
OD
Buettner
Reinhard
R
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis; D018306:Neurocytoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D010386:Pelvic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D010524:Peripheral Nervous System Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016708:Synaptophysin / Q000032:analysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D013521:Urologic Surgical Procedures, Male
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D016708:Synaptophysin