Melanocytic colonization of a meningothelial meningioma: histopathological and ultrastructural findings with immunohistochemical and genetic correlation: case report.
OBJECTIVE
Melanocytic colonization of nonpigmented extracranial tumors has been reported in adenocarcinomas, squamous cell carcinomas, skin appendage tumors, and dermatofibrosarcoma protuberans. To our knowledge, melanocytic colonization of a meningioma has not previously been described.


METHODS
We report an unusual case of a 70-year-old African-American woman who presented with a large frontoparietal meningioma that extended through the calvarium.


METHODS
Craniotomy with gross total resection of the tumor was performed. Histochemistry, immunocytochemistry, ultrastructural analysis, and molecular genetic study via fluorescence in situ hybridization confirmed melanocytic colonization of a meningothelial meningioma.


CONCLUSIONS
With the inclusion of meningothelial meningioma, the spectrum of tumors affected by melanocytic colonization continues to expand.
Nestor
Scott L
SL
Department of Pathology, West Virginia University, Morgantown, West Virginia 26506, USA. snestor@hsc.wvu.edu
Perry
Arie
A
Kurtkaya
Ozlem
O
Abell-Aleff
Patrice
P
Rosemblat
Aldo M
AM
Burger
Peter C
PC
Scheithauer
Bernd W
BW
D000368:Aged; D005260:Female; D006801:Humans; D008544:Melanocytes / Q000473:pathology* / Q000648:ultrastructure*; D008577:Meningeal Neoplasms / Q000235:genetics / Q000473:pathology* / Q000648:ultrastructure*; D008579:Meningioma / Q000235:genetics / Q000473:pathology* / Q000648:ultrastructure*