title: Architectural self-construction in nature and chemical synthesis.
abstract: The chemistry of squalene oxide (1) exemplifies that architectural complexity can be encoded in the structures of relatively simple, polyunsaturated molecules. When the concept of architectural self-construction is an integral part of the design of a chemical synthesis, powerful strategies can be uncovered. this article addresses studies which showed that polyunsaturated, 19-membered ring carbocycle contains all of the molecular information that is required to give the stereochemically complex polycyclic architecture of the cytotoxic natural product FR182877.
authors.affiliation: Department of Chemistry & The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC-123, La Jolla, CA 92037, USA. sorensen@scripps.edu
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Sorensen
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C408303:FR 182877; D011083:Polycyclic Compounds