title: Intratympanic gentamicin for Ménière's disease; a survey of current UK practice.
abstract: Intratympanic gentamicin is increasingly used in the treatment of Ménière's disease. Many protocols have been published for its use, but there is little difference in outcome between them. The goal of the study was therefore to assess current UK practice in the use of intratympanic gentamicin. A postal and e-mail survey of consultant ENT surgeons in the UK was conducted. Of 34 consultants who regularly used intratympanic gentamicin, 21 used a protocol based upon a single intratympanic dose of gentamicin via a needle through the tympanic membrane and repeated after at least a week. The remaining 13 used either a regime of more frequent administration or attempted a more complicated route of delivery in an effort to improve reliability and selectivity of action. In the absence of evidence demonstrating benefit from regimens of increased complexity the majority of consultants are using the simplest possible protocol.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, St Bartholomew's and The Royal London Hospitals, London, UK. robholzer@waitrose.com
authors.forename: R J
authors.initials: RJ
authors.lastname: Obholzer
authors.forename: M J
authors.initials: MJ
authors.lastname: Wareing
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002985:Clinical Protocols; D004333:Drug Administration Routes; D005839:Gentamicins / Q000008:administration & dosage*; D019538:Health Care Surveys; D006801:Humans; D008575:Meniere Disease / Q000188:drug therapy*; D011364:Professional Practice; D006113:United Kingdom
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins