Localized relapse in bone marrow in a posttransplantation patient with t(6;9) acute myeloid leukemia.
We report a 38-year-old woman with t(6;9) acute myeloid leukemia who relapsed with localized leukemic cell growth in the bone marrow after she had undergone allogeneic bone marrow transplantation. The localized cell growth was first recognized by an apparent discrepancy in the DEK-CAN fusion transcript levels between the aspirates from the left and right iliac bone marrow. Magnetic resonance imaging of the iliac bone revealed localized cell accumulation in the left side. The nonhomogeneous and localized leukemic cell growth in this case may have been due to the graft-versus-leukemia effect following allogeneic transplantation with donor lymphocyte infusion. Serial monitoring of molecular markers for leukemia at different sites or magnetic resonance imaging of the bone marrow may be of value in detecting this type of relapse.
Maeda
Tetsuo
T
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Kosugi
Satoru
S
Ujiie
Hidetoshi
H
Osumi
Kazuoki
K
Fukui
Takashi
T
Yoshida
Hitoshi
H
Kashiwagi
Hirokazu
H
Ishikawa
Jun
J
Tomiyama
Yoshiaki
Y
Matsuzawa
Yuji
Y
D000328:Adult; D001853:Bone Marrow / Q000473:pathology*; D016026:Bone Marrow Transplantation; D002896:Chromosomes, Human, Pair 6; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D018365:Neoplasm, Residual / Q000175:diagnosis*; D015513:Oncogene Proteins / Q000235:genetics; D015514:Oncogene Proteins, Fusion; D012334:RNA, Neoplasm / Q000032:analysis; D011993:Recombinant Fusion Proteins / Q000235:genetics; D012008:Recurrence; D014178:Translocation, Genetic; D014184:Transplantation, Homologous
C104001:DEK-CAN fusion protein, recombinant; D015513:Oncogene Proteins; D015514:Oncogene Proteins, Fusion; D012334:RNA, Neoplasm; D011993:Recombinant Fusion Proteins