title: Inhibition of linoleic acid hydroperoxide-induced toxicity in cultured human fibroblasts by anthocyanidins.
abstract: The protective effect of anthocyanidins against the toxicity induced by linoleic acid hydroperoxide (LOOH) was examined in cultured human fetal lung fibroblasts, TIG-7. Cyanidin was more effective than pelargonidin or delphinidin in inhibiting LOOH-induced cytotoxicity. The presence of a catechol moiety in the B ring is shown to be important for the protective activities against the cytotoxicity of LOOH.
authors.affiliation: Redox Regulation Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan. kaneko@tmig.or.jp
authors.forename: Takao
authors.initials: T
authors.lastname: Kaneko
authors.forename: Shoichi
authors.initials: S
authors.lastname: Tahara
authors.forename: Naomichi
authors.initials: N
authors.lastname: Baba
mesh_terms: D000872:Anthocyanins / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology*; D006801:Humans; D008041:Linoleic Acids / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000494:pharmacology*; D017382:Reactive Oxygen Species
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D008041:Linoleic Acids; D008054:Lipid Peroxides; D017382:Reactive Oxygen Species; C008285:linoleic acid hydroperoxide; C066957:pelargonidin; C017154:cyanidin