title: Random analysis of amino acid pairs sensitive to variants in human coagulation factor IX precursor.
abstract: In this study, we used a random approach to determine which amino acid pairs in human coagulation factor IX precursor are more sensitive to its 99 variants. The results show that the randomly unpredictable amino acid pairs are more sensitive to variants.
authors.affiliation: Laboratoire de Toxicocinétique et Pharmacocinétique, Faculté de Pharmacie, Université de la Méditerranée Aix-Marseille II, Marseille, France. hongguanglishibahao@yahoo.com
authors.forename: Guang
authors.initials: G
authors.lastname: Wu
authors.forename: Shaomin
authors.initials: S
authors.lastname: Yan
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000596:Amino Acids / Q000737:chemistry / Q000235:genetics*; D001483:Base Sequence; D003062:Codon; D004247:DNA / Q000235:genetics; D004274:DNA, Recombinant; D005164:Factor IX / Q000737:chemistry* / Q000235:genetics*; D014644:Genetic Variation; D006801:Humans; D009154:Mutation; D011110:Polymorphism, Genetic; D011498:Protein Precursors / Q000737:chemistry / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D003062:Codon; D004274:DNA, Recombinant; D011498:Protein Precursors; D005164:Factor IX; D004247:DNA