Laser and proton radiation to reduce uveal melanoma-associated exudative retinal detachments.
OBJECTIVE
To assess whether laser-induced hyperthermia with proton irradiation of choroidal melanoma may decrease exudative retinal detachments more rapidly.


METHODS
Case control study.


METHODS
Patients treated with laser-induced hyperthermia and proton radiation; results were compared with similar patients treated with only protons.


RESULTS
All 11 patients treated with combined laser and proton therapy had resorption of subretinal fluid with a mean duration of retinal detachment of 193 days compared with 263 days in the group treated with only proton therapy (P <.04). At 1 year, visual acuity was similar.


CONCLUSIONS
Combined laser radiation more rapidly dissipates exudative detachments than radiation alone.
Char
Devron H
DH
Tumori Foundation CPMC , San Francisco, California, USA. devron@tumori.org
Bove
Riley
R
Phillips
Theodore L
TL
D016022:Case-Control Studies; D002830:Choroid Neoplasms / Q000150:complications / Q000628:therapy*; D003131:Combined Modality Therapy; D005122:Exudates and Transudates; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007834:Lasers; D008297:Male; D008545:Melanoma / Q000150:complications / Q000628:therapy*; D008875:Middle Aged; D011522:Protons; D011882:Radiotherapy, High-Energy / Q000379:methods*; D012163:Retinal Detachment / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome; D014792:Visual Acuity
D011522:Protons