title: [Suicidal attempt with colchicine].
abstract: Colchicine is an alkaloid that has been successfully used for a long time in the treatment of acute gout episodes. It's efficacy lies in its inhibition of inflammation cell migration and in the action of specific cytokines, as well as of the production of lactic acid and deposition of uric acid in affected tissues. Colchicine toxicity is rare but may entail highly negative consequences for health unless a rapid gastric decontamination with stomach lavage and active carbon is carried out, and adequate support measures are taken as wellas appropriate hydration and electrolyte replacement. We present the case of a patient who was admitted to hospital after ingesting colchicine with suicidal intention. Colchicine inhibits cell division, which explains its distinct toxicity stages. The lack of proportion existing between ingested dose and clinical impact may result from concomitant treatment with other drugs or from peculiarities in its metabolism.
authors.affiliation: Servicio de Farmacia. Hospital Universitario La Paz, Madrid. Spain.
authors.forename: Y
authors.initials: Y
authors.lastname: Larrubia Marfil
authors.forename: E
authors.initials: E
authors.lastname: Villamañán Bueno
authors.forename: E
authors.initials: E
authors.lastname: Jiménez-Caballero
authors.forename: R
authors.initials: R
authors.lastname: Diazaraque Marín
authors.forename: A
authors.initials: A
authors.lastname: Lucendo Villarín
authors.forename: C
authors.initials: C
authors.lastname: Fernández-Capitán
authors.forename: F
authors.initials: F
authors.lastname: Arnalich Fernández
mesh_terms: D000328:Adult; D003078:Colchicine / Q000378:metabolism / Q000506:poisoning*; D005260:Female; D006074:Gout Suppressants / Q000378:metabolism / Q000506:poisoning*; D006801:Humans; D013406:Suicide, Attempted
chemical_list: D006074:Gout Suppressants; D003078:Colchicine