title: Multifocal visual evoked potential responses in glaucoma patients with unilateral hemifield defects.
abstract: OBJECTIVE
  To determine whether the multifocal visual evoked potential (mfVEP) technique can detect damage to the visual system in the unaffected hemifields of patients with glaucoma and unilateral hemifield defects.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  Monocular mfVEPs and achromatic automated perimetry (AAP) were obtained in both eyes of 16 patients with open-angle glaucoma and unilateral hemifield defects. The mfVEPs were obtained using a pattern-reversal dartboard array with 60 sectors; the entire display was 44.5 degrees in diameter. For each pair of mfVEP responses an interocular ratio of root-mean-square amplitude was calculated. These values were compared with the mean values obtained from 30 control subjects. Probability plots for MfVEP were derived. A cluster analysis was used to determine whether an mfVEP hemifield was normal or abnormal.
  
  
  RESULTS
  Three of 60 (5.0%) mfVEP hemifields from control subjects had significant mfVEP deficits based upon a cluster of abnormal points. Significant mfVEP deficits were detected in the affected AAP hemifield in 15 of 16 (93.8%) glaucoma patients and in 6 of 16 patients in hemifields with apparently normal AAP. The percentage of hemifields with abnormal mfVEPs, but normal AAP, was significantly higher for the glaucoma patients than for the controls (37.5% vs 5.0%, P <.001, chi square).In glaucomatous eyes with achromatic visual fields defects limited to one hemifield, the mfVEP technique can detect evidence of glaucomatous damage in the unaffected hemifield.
authors.affiliation: Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York 10003, USA.
authors.forename: Phamornsak
authors.initials: P
authors.lastname: Thienprasiddhi
authors.forename: Vivienne C
authors.initials: VC
authors.lastname: Greenstein
authors.forename: Candice S
authors.initials: CS
authors.lastname: Chen
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Liebmann
authors.forename: Robert
authors.initials: R
authors.lastname: Ritch
authors.forename: Donald C
authors.initials: DC
authors.lastname: Hood
mesh_terms: D000328:Adult; D005074:Evoked Potentials, Visual; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000503:physiopathology; D006423:Hemianopsia / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis / Q000503:physiopathology; D011336:Probability; D014786:Vision Disorders / Q000175:diagnosis*; D058609:Visual Field Tests / Q000379:methods; D014794:Visual Fields