Dehydrative sialylation with C2-hemiketal sialyl donors.
[reaction: see text] A new method for sialylation involving the dehydrative coupling of sialyl donors with the reagent combination of (p-nitrophenyl)(phenyl) sulfoxide and triflic anhydride is reported. This process establishes sialyl C2-hemiketals as viable sialyl donors for complex carbohydrate synthesis.
Haberman
Jannine M
JM
Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, Illinois 61801, USA.
Gin
David Y
DY
D019158:N-Acetylneuraminic Acid / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D014867:Water; D019158:N-Acetylneuraminic Acid