title: PromoSer: A large-scale mammalian promoter and transcription start site identification service.
abstract: Proximal promoters have a major impact on transcriptional regulation. Studies of the sequence-based nature of this regulation usually require collection of proximal promoter sequences for large sets of co-regulated genes. We report a newly implemented web service that facilitates extraction of user specified regions around the transcription start site of all annotated human, mouse or rat genes. The transcription start sites have been identified computationally by considering alignments of a large number of partial and full-length mRNA sequences to genomic DNA, with provision for alternative promoters. The service is publicly available at http://biowulf.bu.edu/zlab/PromoSer/.
authors.affiliation: Bioinformatics Program, Boston University, 44 Cummington Street, Boston, MA 02215, USA.
authors.forename: Anason S
authors.initials: AS
authors.lastname: Halees
authors.forename: Dmitriy
authors.initials: D
authors.lastname: Leyfer
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Weng
mesh_terms: D000818:Animals; D016678:Genome; D006801:Humans; D020407:Internet; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000737:chemistry; D051381:Rats; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA / Q000379:methods*; D017423:Sequence Analysis, RNA / Q000379:methods; D012984:Software; D024363:Transcription Initiation Site
chemical_list: D012333:RNA, Messenger