title: Diastereoselective synthesis of fluorinated, seven-membered beta-amino acid derivatives via ring-closing metathesis.
abstract: [reaction: see text] Cis and trans seven-membered gamma,gamma-difluorinated beta-amino acid derivatives (III) have been prepared with a sequence that starts with imidoyl halides (I), which are condensed with suitable ester enolates to give intermediates (II). These, in turn, can be cyclized by means of a ring-closing olefin metathesis reaction and the product stereoselectively reduced to yield compounds (III) in good overall yields.
authors.affiliation: Departamento de Química Orgánica, Universidad de Valencia, E-46100 Burjassot, Spain. santos.fustero@uv.es
authors.forename: Santos
authors.initials: S
authors.lastname: Fustero
authors.forename: Ana
authors.initials: A
authors.lastname: Bartolomé
authors.forename: Juan F
authors.initials: JF
authors.lastname: Sanz-Cervera
authors.forename: María
authors.initials: M
authors.lastname: Sánchez-Roselló
authors.forename: Juan
authors.initials: J
authors.lastname: arcía Soler
authors.forename: Carmen
authors.initials: C
authors.lastname: Ramírez de Arellano
authors.forename: Antonio Simón
authors.initials: AS
authors.lastname: Fuentes
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D005461:Fluorine