Renal dysfunction in children with uncomplicated, Plasmodium falciparum malaria in Tamale, Ghana.
In a study performed in Tamale, in the Northern region of Ghana, cystatin C, a new and sensitive indicator of the glomerular filtration rate (GFR), was used to estimate the frequency of renal dysfunction in 78 children with uncomplicated, Plasmodium falciparum malaria. The excretion in urine of albumin, immunoglobulin G and alpha1-microglobulin was also investigated. Plasma concentrations of cystatin C were found to be elevated in 17% of the children, indicating subclinical impairment of renal function. As most (85%) of the children had glomerular as well as tubular patterns of proteinuria, it appears that both glomerulonephritis and damage to tubular cells often occur in P. falciparum malaria.
Burchard
G D
GD
Institut für Tropenmedizin Berlin, Charité, Humboldt-Universität Berlin, Spandauer Damm 130, 14050 Berlin, Germany. gerd.buchard@bni-hmburg.de
Ehrhardt
S
S
Mockenhaupt
F P
FP
Mathieu
A
A
Agana-Nsiire
P
P
Anemana
S D
SD
Otchwemah
R N
RN
Abel
W
W
Brattig
N
N
D058186:Acute Kidney Injury / Q000150:complications* / Q000503:physiopathology; D000419:Albuminuria / Q000150:complications / Q000503:physiopathology; D000510:Alpha-Globulins / Q000652:urine; D002675:Child, Preschool; D055316:Cystatin C; D015891:Cystatins / Q000097:blood; D015853:Cysteine Proteinase Inhibitors / Q000097:blood; D005260:Female; D005869:Ghana; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007074:Immunoglobulin G / Q000652:urine; D007684:Kidney Tubules / Q000503:physiopathology; D016778:Malaria, Falciparum / Q000150:complications* / Q000503:physiopathology; D008297:Male; D011480:Protease Inhibitors / Q000652:urine
D000510:Alpha-Globulins; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D015853:Cysteine Proteinase Inhibitors; D007074:Immunoglobulin G; D011480:Protease Inhibitors; C016001:alpha-1-microglobulin