P2Y receptors: biological advances and therapeutic opportunities.
The P2 family of membrane-bound receptors is activated by naturally occurring nucleotides. When activated, these widely distributed receptors elicit cellular signaling which mediate multiple tissue-specific effects throughout the body. P2X receptors are ligand-gated ionotropic channels, while P2Y receptors belong to the superfamily of metabotropic G protein-coupled receptors. To date, there are six human cloned and functionally characterized subtypes of the P2Y family: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11 and P2Y12. There exists enough agonist specificity between receptor subtypes to allow functional identification of newly found putative receptors. There are few specific antagonists of the P2Y receptors.
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Inspire Pharmaceuticals Inc., 4222 Emperor Boulevard, Suite 470, Durham, NC 27703, USA. samray@inspirepharm.com
D000818:Animals; D002986:Clinical Trials as Topic; D015352:Dry Eye Syndromes / Q000188:drug therapy; D006801:Humans; D007150:Immunohistochemistry; D008024:Ligands; D058910:Purinergic P2 Receptor Agonists; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2 / Q000187:drug effects* / Q000378:metabolism; D014018:Tissue Distribution
D008024:Ligands; D058910:Purinergic P2 Receptor Agonists; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2