title: Emodinol, beta-glucuronidase inhibiting triterpene from Paeonia emodi.
abstract: Emodinol, a new oleane type triterpene, has been isolated from the chloroform soluble fraction of Paeonia emodi. The structure 1beta, 3beta, 23-trihydroxyolean-12-en-28-oic acid 1 has been assigned on the basis of spectral studies including 2D NMR. It showed significant beta-glucuronidase inhibitory activity. In addition benzoic acid and 3-hydroxybenzoic acid have also been reported for the first time from this species.
authors.affiliation: International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Naheed
authors.initials: N
authors.lastname: Riaz
authors.forename: Itrat
authors.initials: I
authors.lastname: Anis
authors.lastname: Aziz-ur-Rehman
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Zaheer
authors.initials: Z
authors.lastname: Ahmed
authors.forename: Pir
authors.initials: P
authors.lastname: Muhammad
authors.forename: Shahida
authors.initials: S
authors.lastname: Shujaat
authors.lastname: Atta-ur-Rahman
mesh_terms: D005966:Glucuronidase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029596:Paeonia / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C478118:1beta, 3beta, 23-trihydroxyolean-12-en-28-oic acid; D014315:Triterpenes; D009828:Oleanolic Acid; D005966:Glucuronidase