Islet transplant: an option for childhood diabetes?
Careful assessment of the safety and efficacy of islet transplantation should guide the selection process of a small number of children with type 1 diabetes who may be eligible for the procedure--some of whom are already receiving immunosuppression because of a previous transplant, others who are scheduled to receive de novo islet alone transplantation because of a life threatening risk of hypoglycemia. The outcomes of these initial investigations are predicted to shape the future boundaries of islet transplantation, diabetes, and transplantation.
Hathout
E
E
Division of Endocrinology and Diabetes, Loma Linda University Children's Hospital, Loma Linda, USA.
Lakey
J
J
Shapiro
J
J
D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016381:Islets of Langerhans Transplantation; D018579:Patient Selection; D018570:Risk Assessment