Assessment of protein allergenicity on the basis of immune reactivity: animal models.
Because of the public concern surrounding the issue of the safety of genetically modified organisms, it is critical to have appropriate methodologies to aid investigators in identifying potential hazards associated with consumption of foods produced with these materials. A recent panel of experts convened by the Food and Agriculture Organization and World Health Organization suggested there is scientific evidence that using data from animal studies will contribute important information regarding the allergenicity of foods derived from biotechnology. This view has given further impetus to the development of suitable animal models for allergenicity assessment. This article is a review of what has been achieved and what still has to be accomplished regarding several different animal models. Progress made in the design and evaluation of models in the rat, the mouse, the dog and in swine is reviewed and discussed.
Kimber
Ian
I
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, United Kingdom. ian.kimber@syngenta.com
Dearman
Rebecca J
RJ
Penninks
Andre H
AH
Knippels
Leon M J
LM
Buchanan
Robert B
RB
Hammerberg
Bruce
B
Jackson
Hilary A
HA
Helm
Ricki M
RM
D000284:Administration, Oral; D000818:Animals; D004044:Dietary Proteins / Q000009:adverse effects* / Q000276:immunology*; D004195:Disease Models, Animal; D004285:Dogs; D005512:Food Hypersensitivity / Q000503:physiopathology* / Q000662:veterinary; D006801:Humans; D007263:Infusions, Parenteral; D051379:Mice; D008807:Mice, Inbred BALB C; D021183:Peanut Hypersensitivity / Q000276:immunology / Q000503:physiopathology; D051381:Rats; D018570:Risk Assessment; D013552:Swine
D004044:Dietary Proteins