The sigma B regulon influences internalization of Staphylococcus aureus by osteoblasts.
Individual strains of Staphylococcus aureus have different capacities to become internalized by osteoblasts. Here we report that the levels of sigma(B) expressed by S. aureus correlate with the capacity of this bacterium to be internalized by osteoblasts. However, sigma(B) is not essential for internalization and does not necessarily account for the differences in the capacities of strains to be internalized.
Nair
Sean P
SP
Cellular Microbiology Research Group, Eastman Dental Institute for Oral Health Care Sciences, University College London, London WC1X 8LD, United Kingdom. snair@eastman.ucl.ac.uk
Bischoff
Markus
M
Senn
Maria M
MM
Berger-Bächi
Brigitte
B
D001426:Bacterial Proteins / Q000235:genetics* / Q000502:physiology; D002460:Cell Line; D006801:Humans; D009876:Operon; D010006:Osteoblasts / Q000382:microbiology*; D018085:Regulon / Q000502:physiology*; D012808:Sigma Factor / Q000235:genetics* / Q000502:physiology; D013211:Staphylococcus aureus / Q000235:genetics*
D001426:Bacterial Proteins; C079011:SigB protein, Bacteria; D012808:Sigma Factor