"Recruitment signals" from apoptotic cells: invitation to a quiet meal.
An evolutionarily conserved machinery exists for engulfment of apoptotic cells from worm to mammals. New observations suggest that corpse clearance is tightly linked to apoptosis and that dying cells use both recruitment and eat-me signals for phagocyte attraction and recognition.
Ravichandran
Kodi S
KS
Carter Immunology Center and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA. ravi@virginia.edu
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics; D010586:Phagocytes / Q000166:cytology / Q000378:metabolism*; D010587:Phagocytosis / Q000235:genetics*; D010743:Phospholipids / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*
D010743:Phospholipids; D011956:Receptors, Cell Surface