An unusual oxidative cyclization: studies towards the biomimetic synthesis of pyridomacrolidin.
An unusual oxidative cyclization of a N-hydroxy pyridone 9 with Z-2-cyclodecenone 11 has been achieved, thus demonstrating a possible biomimetic route to pyridomacrolidin 2. [reaction: see text]
Irlapati
Nageswara Rao
NR
Dyson Perrins Laboratory, Department of Chemistry, Oxford University, South Parks Road, Oxford OX1 3QY, United Kingdom.
Baldwin
Jack E
JE
Adlington
Robert M
RM
Pritchard
Gareth J
GJ
Cowley
Andrew
A
D032701:Biomimetics; D003500:Cyclization; D007659:Ketones / Q000737:chemistry; D010084:Oxidation-Reduction; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry
D007659:Ketones; D011728:Pyridones; C114117:pyridomacrolidin