title: Vaccine efficacy of a lysine auxotroph of Mycobacterium tuberculosis.
abstract: The in vivo growth phenotype and vaccine efficacy of a lysine auxotrophic mutant of Mycobacterium tuberculosis strain H37Rv are described. An immunization experiment using a mouse model with an aerosol challenge showed that two doses of the M. tuberculosis mutant were required to generate protection equivalent to that of the Mycobacterium bovis BCG vaccine.
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
authors.forename: Martin S
authors.initials: MS
authors.lastname: Pavelka
authors.forename: Bing
authors.initials: B
authors.lastname: Chen
authors.forename: Cynthia L
authors.initials: CL
authors.lastname: Kelley
authors.forename: Frank M
authors.initials: FM
authors.lastname: Collins
authors.forename: William R
authors.initials: WR
authors.lastname: Jacobs
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000276:immunology; D008239:Lysine / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000378:metabolism*; D032581:Tuberculosis Vaccines / Q000276:immunology*; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology
chemical_list: D001500:BCG Vaccine; D032581:Tuberculosis Vaccines; D014613:Vaccines, Attenuated; D008239:Lysine