Imperceptible effect of radiation based on stable type chromosome aberrations accumulated in the lymphocytes of residents in the high background radiation area in China.
Cytogenetic investigation of stable type aberrations (translocations) was performed with our improved methods in 6 children and 15 elderly persons in a high background radiation area (HBRA) in China, and in 8 children and 11 elderly persons in a control area. The total numbers of cells analyzed in elderly persons were 68,297 in HBRA and 35,378 in controls and in children were 45,535 in HBRA and 56,198 in controls. On average 5138 cells per subject were analyzed. The variation in the frequencies of translocations per 1000 cells was small in children while it was large in elderly persons. No significant difference was found in the frequencies between HBRA and control (P > 0.05, Mann-Whitney U test). On the other hand, correlation between age and translocation frequencies was significant at the 1% level (rs = 0.658 with 37DF, Spearman rank correlation test). The contribution of an elevated level of natural radiation in HBRA in China to the induction of stable type chromosome aberrations does not have a significant effect compared with the contribution of chemical mutagens and/or metabolic factors. The present study suggests that the probability of the risk of causing malignant and/or congenital diseases by the increased amount of radiation is imperceptible in HBRA where the level of natural radiation is 3 to 5 times higher than that in the control area.
Zhang
Wei
W
National Institute for Radiological Protection and Nuclear Safety, Chinese Center for Disease Control and Prevention, Beijing 100088, China.
Wang
Chunyan
C
Chen
Deqing
D
Minamihisamatsu
Masako
M
Morishima
Hiroshige
H
Yuan
Yongling
Y
Wei
Luxin
L
Sugahara
Tsutomu
T
Hayata
Isamu
I
D000368:Aged; D001417:Background Radiation / Q000009:adverse effects*; D002648:Child; D002681:China; D002869:Chromosome Aberrations / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D011874:Radiometry; D014178:Translocation, Genetic