Carcinoma in situ spread to mucosa of sigmoid colon neobladder.
This is the first case of carcinoma in situ (CIS) of a transitional cell carcinoma that had spread into a neobladder constructed using a bowel segment associated with local recurrence at the ureteral-neobladder anastomosis. Considering that the CIS lesion was found in macroscopically intact epithelium remote from the main tumor, this strongly suggests that CIS could arise from solid tumor by implantation. Although some studies have reported secondary malignancy occurring in the neobladder, most have been adenocarcinoma that arose from the replaced bowel segment. To our knowledge, the present case is the first of widespread CIS of transitional cell carcinoma in an orthotopic neobladder.
Hara
Isao
I
Division of Urology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Japan
Hara
Shoji
S
Miyake
Hideaki
H
Kawabata
Gaku
G
Okada
Hiroshi
H
Kamidono
Sadao
S
D000368:Aged; D002278:Carcinoma in Situ / Q000209:etiology / Q000473:pathology*; D002295:Carcinoma, Transitional Cell / Q000556:secondary*; D012809:Colon, Sigmoid / Q000601:surgery; D015653:Cystectomy; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D009366:Neoplasm Seeding; D011183:Postoperative Complications / Q000473:pathology*; D012811:Sigmoid Neoplasms / Q000209:etiology / Q000556:secondary*; D014513:Ureter / Q000473:pathology; D014516:Ureteral Neoplasms / Q000556:secondary; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000601:surgery; D014547:Urinary Diversion