Neurodegeneration: how does parkin prevent Parkinson's disease?
Mutations in parkin cause Parkinson's disease due to the loss of the ubiquitin-protein ligase activity of Parkin protein. Recent data suggest we may be beginning to understand the nature of the proteins that are targeted by Parkin and how these cause neuronal damage.
Cookson
Mark R
MR
Laboratory of Neurogenetics, National Institute on Aging, NIH, Bldg 10, Room 6C103, MSC1589, 9000 Rockville Pike, Bethesda, MD 20892, USA. Cookson@mail.nih.gov
D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D010300:Parkinson Disease / Q000503:physiopathology*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D051843:Synucleins; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D014452:Ubiquitins / Q000378:metabolism*
C480827:GPR37 receptor, human; D009419:Nerve Tissue Proteins; D043562:Receptors, G-Protein-Coupled; D051843:Synucleins; D014452:Ubiquitins; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein