title: [Nosocomial urinary infection due to Trichosporon asahii. First two cases in Chile].
abstract: We present two cases of nosocomial urinary tract infection due to Trichosporon asahii in intensive care unit patients with bladder catheter from two hospitals in Santiago, Chile. Both patients had an several catheters and bacterial infections that required the use of antibiotic therapy. One strain showed in vitro resistance to amphotericin B. Both strains were susceptible to fluconazole, but presented MIC with dose-dependent susceptibility to ketoconazole and itraconazole. This is the first report showing T. asahii as urinary tract infection agent in Chile.
authors.affiliation: Programa de Microbiología y Micología, ICBM, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago, Chile. vsilva@machi.med.uchile.cl
authors.forename: Víctor
authors.initials: V
authors.lastname: Silva
authors.forename: Guillermo
authors.initials: G
authors.lastname: Zepeda
authors.forename: Daniel
authors.initials: D
authors.lastname: Alvareda
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002677:Chile / Q000453:epidemiology; D021821:Communicable Diseases, Emerging / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D003428:Cross Infection / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D017809:Fatal Outcome; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D007362:Intensive Care Units; D017964:Itraconazole / Q000494:pharmacology; D007654:Ketoconazole / Q000494:pharmacology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications; D009181:Mycoses / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D009894:Opportunistic Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D010300:Parkinson Disease / Q000150:complications; D011183:Postoperative Complications / Q000188:drug therapy / Q000382:microbiology; D014250:Trichosporon / Q000187:drug effects / Q000302:isolation & purification*; D014546:Urinary Catheterization / Q000009:adverse effects; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D017287:Ventriculoperitoneal Shunt / Q000009:adverse effects
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole; D007654:Ketoconazole