Synaptic plasticity: importance of proteasome-mediated protein turnover.
The ubiquitin-proteasome system regulates protein degradation in every eukaryotic cell. Recent work has shown that protein turnover mediated by the ubiquitin-proteasome system plays a key role in synaptic plasticity.
Cline
Hollis
H
Cold Spring Harbor Laboratory, Beckman Building, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
D001369:Axons / Q000502:physiology; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D011506:Proteins / Q000378:metabolism*; D013569:Synapses / Q000502:physiology*; D025801:Ubiquitin / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
D009097:Multienzyme Complexes; D011506:Proteins; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex