title: Ovarian follicle growth and consequences for fertility in sheep.
abstract: Understanding the pattern of ovarian follicle development is seen as an important step leading to the development of techniques that maximise fertility in sheep. Repeated observations of the growth of individual follicles have led to the understanding that follicles develop in a wave-like pattern during the oestrous cycle, with two to four waves per cycle being the most common. The ease with which follicle waves are described seems to depend on the their frequency and the number of follicles per wave. There is evidence for the largest follicle(s) of a follicle wave inhibiting the development of other follicles; however, in some cases this is not apparent as other follicle waves emerge when a previous large, healthy follicle is still present. Follicle development can be manipulated using exogenous gonadotrophins or progestagens and these have been shown to alter the number or age profile of developing follicles. The ovulation of aged follicles in cattle clearly has a detrimental effect on fertility, but this relationship is less clear and seems to be less critical in sheep. Recent findings at the molecular level show that the bone morphogenetic proteins (BMP) and their receptors are critically involved in the control of ovulation rate, but fully understanding their mechanism remains to be described. This highlights the potential for the integration of molecular and physiological findings to better develop methods to manipulate follicle development and reproduction in sheep.
authors.affiliation: Faculty of Agriculture, and The Centre for Integrative Biology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. alex.evans@ucd.ie
authors.forename: A C O
authors.initials: AC
authors.lastname: Evans
mesh_terms: D000780:Anestrus; D000818:Animals; D030762:Estrous Cycle; D005260:Female; D005298:Fertility; D006080:Ovarian Follicle / Q000254:growth & development* / Q000502:physiology; D010060:Ovulation; D012756:Sheep / Q000502:physiology*