[Mitosis under control].
The mitotic checkpoint is essential to ensure accurate chromosome segregation by allowing a mitotic delay in response to a spindle defect. This checkpoint postpones the onset of anaphase until all the chromosomes are attached and correctly aligned onto the mitotic spindle. The checkpoint functions by preventing an ubiquitin ligase called the anaphase-promoting complex (APC) from ubiquitinylating proteins whose degradation is required for anaphase onset. Loss of this checkpoint results in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in most of the tumour cells.
Castro
Anna
A
Centre de recherche de biochimie macromoléculaire, Cnrs UPR 1086, 1919, route de Mende, 34293 Montpellier, France.
Vigneron
Suzanne
S
Lorca
Thierry
T
Labbé
Jean-Claude
JC
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D002875:Chromosomes; D005786:Gene Expression Regulation; D006801:Humans; D008025:Ligases / Q000494:pharmacology*; D008938:Mitosis / Q000502:physiology*; D009369:Neoplasms / Q000503:physiopathology; D008941:Spindle Apparatus; D043743:Ubiquitin-Protein Ligase Complexes
D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D008025:Ligases