Polyphenols from some foodstuffs as inhibitors of ovalbumin permeation through caco-2 cell monolayers.
Some spices showed high inhibitory activity against ovalbumin permeation through Caco-2 cell monolayers. Pimentol from allspice, rosmarinic acid and luteolin-7-O-beta-glucuronide from thyme, quercetin-3-O-beta-glucuronide from coriander and rutin from tarragon were identified as the active principles. A structure-activity relationship study among the active isolates and their related compounds indicated that the presence of a catechol structure played an important role in the inhibitory activity of each compound.
Kobayashi
Shoko
S
Department of Health and Nutrition, Takasaki University of Health and Welfare, Takasaki 370-0033, Japan. teshoko@takasaki-u.ac.jp
Watanabe
Jun
J
Fukushi
Eri
E
Kawabata
Jun
J
Nakajima
Mitsutoshi
M
Watanabe
Michiko
M
D018926:Anti-Allergic Agents / Q000737:chemistry*; D018938:Caco-2 Cells; D002396:Catechols / Q000032:analysis / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D005502:Food; D006801:Humans; D010047:Ovalbumin / Q000037:antagonists & inhibitors* / Q000493:pharmacokinetics; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D059808:Polyphenols; D017365:Spices; D013329:Structure-Activity Relationship
D018926:Anti-Allergic Agents; D002396:Catechols; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D010047:Ovalbumin