[The expression of proliferating cell nuclear antigen and Bcl-2 oncoprotein in nasopharyngeal carcinoma].
OBJECTIVE
To observe PCNA, Bcl-2 gene expression and their relationship with clinicopathologic factors in primary nasopharyngeal carcinoma(NPC).


METHODS
PCNA, Bcl-2 proteins were assayed with immunohistochemical technique.


RESULTS
The expression of Bcl-2 protein was 9.5% in chronic inflammation of nasopharyngeal epithelium(CINE), which was significantly lower than it in NPCs with 83.1% (P < 0.01). In NPCs, we could find PCNA and Bcl-2 expression were significantly negatively correlated with each other(rs = -0.41, P < 0.01). In our study, there was some correlation in the grade of PCNA proliferating index(PI) with the clinical stages or cervical lymph node metastasis of NPCs.


CONCLUSIONS
PCNA PI may represent the proliferative state of NPC, Bcl-2 protein may be a better tumor marker of NPC, all of them may play important roles in the pathogenesis of nasopharyngeal carcinoma.
Cheng
Qing
Q
Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
Huang
Xiang
X
Wang
Jibao
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*
D018809:Proliferating Cell Nuclear Antigen; D019253:Proto-Oncogene Proteins c-bcl-2