title: [Multiple coronary arteriovenous fistulae. Hazard or predetermination?].
abstract: OBJECTIVE
  The authors present the clinical cases of three adult patients (49, 53 and 61 year-old), with rheumatic cardiac valvulopathy, and bilateral coronary arteriovenous fistulae draining in the main pulmonary artery. Based on documental investigation, the authors speculate about the predeterminate origin of coronary arteriovenous fistulae.
  
  
  CONCLUSIONS
  At first glance, it seems obvious that congenital cardiopathies occur at random, i.e., embryonic development deviate or stops due to unknown reasons, originating the persistence of lacunar blood spaces prior to the development of coronary arteries cords. There are two factors involved in the genesis of congenital malformations: a genomic preexisting factor and the presence of an environmental precipitating factor, i.e., isolated pulmonary valve atresia or left ventricular hypoplastic syndrome, with mitral and aortic valve stenosis, can predispose development of coronary arteriovenous fistulae. Recently, the question has been raised whether there is a relation of coronary arteries fistulae with: ethnic groups, hereditary gigantism, autoimmune diseases, such as polymyositis, hereditary hemorrhagic telangiectasia, and apical hypertrophic myocardiopathy.
  
  
  CONCLUSIONS
  Coronary arteriovenous fistulae, as well as some congenital cardiopathies, could be due to chromosome alterations or might be related to hereditary diseases, such as hemorrhagic telangiectasia, induced by a disturbed genetic program. Although, there is no concrete evidence that a genetic factor is related to the development of coronary arteriovenous fistulae, there are signs that suggest that such a possibility could be investigated.
authors.affiliation: Servicio de Hemodinamia, Hospital de Especialidades, CMN La Raza, IMSS, México, DF, México. rangel_albertomx@yahoo.com.mx
authors.forename: Alberto
authors.initials: A
authors.lastname: Rangel
authors.forename: Luis
authors.initials: L
authors.lastname: Muñoz-Castellanos
authors.forename: Sergio
authors.initials: S
authors.lastname: Solorio
mesh_terms: D001164:Arteriovenous Fistula / Q000000981:diagnostic imaging*; D017023:Coronary Angiography; D003330:Coronary Vessel Anomalies / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000002:abnormalities* / Q000000981:diagnostic imaging