Linker chain effect of ferrocenyl naphthalene diimide on a double stranded DNA preference.
Naphthalene diimide derivative 1 carrying two 3-(ferrocenyl-methylamino)-propyl substituents was synthesized as a new hybrid indicator for electrochemical gene sensing. Ligand 1 showed a preference for double stranded DNA four-times larger than 2 previously described. The peak potential of 1 shifted 30 mV toward the negative side from that of 2, thereby shortening the time required for gene detection.
Sato
S
S
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
Takamiya
H
H
Yamashita
K
K
Takagi
M
M
Kondo
H
H
Takenaka
S
S
D015374:Biosensing Techniques; D004247:DNA / Q000032:analysis* / Q000378:metabolism; D004563:Electrochemistry; D005296:Ferrous Compounds / Q000737:chemistry* / Q000378:metabolism; D007094:Imides / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D008024:Ligands
D005296:Ferrous Compounds; D007094:Imides; D008024:Ligands; C406363:ferrocenylnaphthalene diimide; D004247:DNA