[Expression of Ki-67 antigen in ameloblastoma and its clinical significance].
OBJECTIVE
The expression of Ki-67 antigen of ameloblastoma was examined in order to investigate the different proliferation activity of histological variants of ameloblastoma and its clinical significance.


METHODS
70 cases of different histological specimen of ameloblastoma were analyzed by immunohistochemical method using Ki-67 antibody. The Label Index was calculated in percentage of Ki-67 positive cells after examined with an image analysis system.


RESULTS
The results showed that the Labeled Index in malignant ameloblastoma was the highest 14.72% +/- 2.87%. The Labeled Index in solid ameloblastoma was in the middle, among which the follicular 4.42% +/- 1.05% was higher than the plexiform 3.64% +/- 1.23%. The Labeled Index in mono-cystic ameloblastoma was the lowest 2.21% +/- 1.09%.


CONCLUSIONS
The results demonstrated that the proliferation activity varied according to the histological pattern of ameloblastoma. The prognosis with different proliferation activity was also varied accordingly.
Han
Bo
B
Oral and Maxillofacial Department, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Li
Longjiang
L
Wang
Hu
H
D000564:Ameloblastoma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007573:Jaw Neoplasms / Q000378:metabolism* / Q000473:pathology; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D009364:Neoplasm Recurrence, Local; D009808:Odontogenic Tumors / Q000378:metabolism* / Q000473:pathology
D019394:Ki-67 Antigen