Interleukin 1 receptor antagonist (IL-1RA) polymorphism in women with cervical cancer.
BACKGROUND
Several studies suggest that immunological components play a key role in the development of cervical cancer. Polymorphism in the IL-1 RA gene was associated with various malignant diseases. Data is lacking for cervical cancer.


METHODS
In a prospective study we analysed the polymorphism of IL-1RA in 113 women with cervical cancer and 107 with benign diseases. Genomic DNA fragments were amplified by PCR.


RESULTS
The distribution of genotype frequencies was different between the study and control group with respect to allele 2 heterozygotes (24.8% vs. 13.1%; p = 0.04) but not in the frequencies of allele 1/3 and homozygous allele 2. There were no differences between IL-1 RA 1/2 polymorphism and all other alleles in tumour stage, grading, recurrence status and age.


CONCLUSIONS
This data supports the role for allele 2 of the gene encoding for IL1-RA as a genetic determinant of cervical cancer.
Mustea
Alexander
A
Charité, Department of Obstetrics and Gynaecology, Humboldt University, Augustenburger Platz 1, D-13353 Berlin, Germany. amustea@yahoo.com
Sehouli
Jalid
J
Könsgen
Dominique
D
Stengel
Dirk
D
Sofroni
Dumitru
D
Lichtenegger
Werner
W
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007633:Keratins / Q000032:analysis; D008875:Middle Aged; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012795:Sialoglycoproteins / Q000235:genetics*; D002577:Uterine Cervical Diseases / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D012795:Sialoglycoproteins; D007633:Keratins