Pharmacological effects of extracts from Valeriana adscendens Trel. II. Effects on GABA uptake and amino acids.
Methanolic and aqueous extracts from Valeriana adscendens (Valerianaceae), that previously demonstrated neuroleptic-like properties, were studied for their effects on GABA uptake and amino acid neurotransmitter levels. The methanolic estract showed a significant effect in inhibiting GABA uptake and in decreasing the intracellular content of amino acid neurotransmitters in crude synaptosomes of rat. The data obtained could explain the neuroleptic activity of methanolic extract of the plant and confirm its traditional use.
De Feo
Vincenzo
V
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Fisciano (Salerno), Italy. defeo@unisa.it
Faro
Carlos
C
D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism*; D014632:Valerian; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D014150:Antipsychotic Agents; D018377:Neurotransmitter Agents; D010936:Plant Extracts; D005680:gamma-Aminobutyric Acid