IL-4 and CXCR4 upregulation in HIV-infected and uninfected individuals from Maharashtra-Mumbai.
We extended the investigation of the virus-host interaction in developing countries by analysing Indian HIV-infected and uninfected individuals from Maharashtra-Mumbai. Results showed that CXCR4 messenger RNA and surface expression, as well as IL-4 mRNA and T allele frequency at the -589 site in the IL-4 gene (high IL-4 production) were significantly increased in Indian compared with Italian individuals. Because IL-4 stimulates CXCR4 expression this observation could be explained by the higher frequency of the -589T IL-4 polymorphism.
Biasin
Mara
M
Department of Immunology, Universita di Milano, 20157 Milan, Italy.
Boasso
Adriano
A
Piacentini
Luca
L
Trabattoni
Daria
D
Magri
Giuliana
G
Deshmuks
Ranjana
R
Deshpande
Alaka
A
Clerici
Mario
M
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003906:Developing Countries; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D007194:India; D015847:Interleukin-4 / Q000032:analysis* / Q000235:genetics; D018950:Lipopolysaccharide Receptors / Q000276:immunology; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000032:analysis; D019713:Receptors, CCR5 / Q000032:analysis / Q000235:genetics; D019718:Receptors, CXCR4 / Q000032:analysis* / Q000235:genetics; D018709:Statistics, Nonparametric; D013601:T-Lymphocytes / Q000276:immunology*
D018950:Lipopolysaccharide Receptors; D012333:RNA, Messenger; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D015847:Interleukin-4