[Infantile and maternal choriocarcinoma].
Infantile or congenital choriocarcinoma is a very uncommon complication of gestational choriocarcinoma. We report such a case with fatal outcome in a 3-week-old newborn, admitted for a hemorrhagic syndrome. Lungs, liver and brain masses were discovered and suggested an angiomatous process. The diagnosis was made later on gingival biopsy with necropsic confirmation. The mother's B-HCG level was elevated. She had asymptomatic pulmonary nodules and a uterine mass. This case report highlights characteristic but non specific clinical findings leading to the diagnosis. Chemotherapy must be undertaken as soon as possible to be effective. It is also necessary to assay maternal serum B-HCG when infantile choriocarcinoma is disclosed.
Lazure
Thierry
T
Service d'Anatomie et de Cytologie Pathologiques, CHU de Bicêtre, Le Kremlin-Bicêtre.
Durand
Philippe
P
Chevret
Laurent
L
Cuilliere
Peggy
P
Pariente
Danièle
D
Bui
Matthieu
M
Lhomme
Catherine
C
Fabre
Monique
M
D002822:Choriocarcinoma / Q000151:congenital* / Q000175:diagnosis / Q000473:pathology; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000473:pathology
D018997:Chorionic Gonadotropin, beta Subunit, Human