Cell transplantation to improve ventricular function in the failing heart.
Current therapies for congestive heart failure are limited in efficacy or in applicability. Cardiac cell transplantation offers a novel therapeutic approach to improve heart function. Although significant progress has been made over the past decade in the development of cell transplantation, only recently have investigators studied the changes in ventricular function following cell transplantation. This review article describes the latest research developments, evaluates recent studies of ventricular function after cell transplantation, and discusses the future directions of cell transplantation as a new therapy to 'repair broken hearts'.
Tang
Gilbert H L
GH
Division of Cardiovascular Surgery, Toronto General Hospital, Department of Surgery, University of Toronto, Ontario, Toronto, Canada.
Fedak
Paul W M
PW
Yau
Terrence M
TM
Weisel
Richard D
RD
Kulik
Alex
A
Mickle
Donald A G
DA
Li
Ren-Ke
RK
D000818:Animals; D016026:Bone Marrow Transplantation; D004452:Echocardiography; D004553:Electric Conductivity; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D023421:Models, Animal; D017202:Myocardial Ischemia / Q000150:complications / Q000175:diagnosis; D032383:Myocytes, Cardiac / Q000637:transplantation*; D010477:Perfusion; D015899:Tomography, Emission-Computed, Single-Photon; D018754:Ventricular Dysfunction / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*