In vitro susceptibilities of Malassezia species to a new triazole, albaconazole (UR-9825), and other antifungal compounds.
The in vitro activity of the new triazole albaconazole (UR-9825) in comparison with those of flucytosine, fluconazole, ketoconazole, itraconazole, and voriconazole against 70 strains of Malassezia spp. was determined by a microdilution method using a colorimetric indicator for metabolic activity. Albaconazole showed an in vitro profile similar to those of the different antifungals tested (MIC <or= 0.06 microg/ml for all the strains).
Garau
Margarita
M
Department of Microbiology, Hospital Universitario 12 de Octubre, Madrid, Spain.
Pereiro
Manolo
M
del Palacio
Amalia
A
D000935:Antifungal Agents / Q000494:pharmacology*; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology; D005437:Flucytosine / Q000494:pharmacology; D066298:In Vitro Techniques; D017964:Itraconazole / Q000494:pharmacology; D007654:Ketoconazole / Q000494:pharmacology; D008290:Malassezia / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000494:pharmacology; D011799:Quinazolines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D011799:Quinazolines; D014230:Triazoles; D017964:Itraconazole; D015725:Fluconazole; D005437:Flucytosine; D065819:Voriconazole; D007654:Ketoconazole; C112424:albaconazole