The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks.
All cell types express a great variety of G protein-coupled receptors (GPCRs) that are coupled to only a limited set of G proteins. This disposition favors cross-talk between transduction pathways. However, GPCRs are organized into functional units. They promote specificity and thus avoid unsuitable cross-talk. New methodologies (mostly yeast two-hybrid screens and proteomics) have been used to discover more than 50 GPCR-associated proteins that are involved in building these units. In addition, these protein networks participate in the trafficking, targeting, signaling, fine-tuning and allosteric regulation of GPCRs. To date, proteins that interact with the GPCR C-terminus are the most abundant and are the focus of this review.
Bockaert
Joël
J
Laboratoire de Génomique Fonctionnelle, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier Cedex 5, France. joel.bockaert@ccipe.cnrs.fr
Marin
Philippe
P
Dumuis
Aline
A
Fagni
Laurent
L
D000494:Allosteric Regulation; D000818:Animals; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D020239:Receptor Cross-Talk; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction
D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins