title: A regioselective approach to 5-substituted-3-amino-1,2,4-triazines.
abstract: Nucleophilic displacement of readily available alpha,alpha-dibromoketones with excess morpholine gave the corresponding ketoaminals, which upon condensation with aminoguanidine in MeOH in the presence of AcOH afforded 5-substituted-3-amino-1,2,4-triazines in >95% regioselectivity and 45-76% isolated yield. [reaction: see text]
authors.affiliation: Department of Process Research, Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, NJ 07065, USA. john_limanto@merck.com
authors.forename: John
authors.initials: J
authors.lastname: Limanto
authors.forename: Richard A
authors.initials: RA
authors.lastname: Desmond
authors.forename: Donald R
authors.initials: DR
authors.lastname: Gauthier
authors.forename: Paul N
authors.initials: PN
authors.lastname: Devine
authors.forename: Robert A
authors.initials: RA
authors.lastname: Reamer
authors.forename: R P
authors.initials: RP
authors.lastname: Volante