Regioselective [2 + 2 + 2] cycloaddition of a nickel-benzyne complex with 1,3-diynes.
[reaction: see text] Reactions of nickel(0)-benzyne complexes with a range of symmetrically substituted 1,3-diynes in the presence of triethylphosphine lead to the regioselective formation of 2,3-dialkynyl naphthalenes. The regioselectivity can be reversed when the diyne possesses substituents of high steric bulk, allowing selective formation of either symmetric dialkynyl naphthalene.
Deaton
Kimberly R
KR
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Gin
Mary S
MS