Synthesis and characterization of a macrocyclic near-infrared optical scaffold.
Macrocyclization of a bioactive peptide with a bifunctional near-infrared fluorescent optical probe gives a compound that retained the receptor binding affinity of the peptide and the photophysical properties of the optical probe. The robust nature of the new compound provides a structural framework for optimizing the activity of bioactive molecules and for monitoring chemical or biological processes in vivo and in vitro by near-infrared optical methods.
Ye
Yunpeng
Y
Department of Radiology, Washington University, St. Louis, Missouri 63110, USA.
Li
Wen Ping
WP
Anderson
Carolyn J
CJ
Kao
Jeffery
J
Nikiforovich
Gregory V
GV
Achilefu
Samuel
S
D003500:Cyclization; D046911:Macromolecular Substances; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D017481:Receptors, Somatostatin / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared
D046911:Macromolecular Substances; D009842:Oligopeptides; D010456:Peptides, Cyclic; D017481:Receptors, Somatostatin