title: Familial gliomas. Analysis of six families with cerebral gliomas and without other inheritable syndromes.
abstract: Although a familial tendency to develop brain tumors in the absence of well-recognized hereditary disorders is an important issue, it has been rarely reported. Studies of the familial occurrence of gliomas have yielded conflicting results. This phenomenon may be imputable to chance or environmental or hereditary factors. Furthermore, epidemiological and genetic investigations are fundamental to evidence of whether hereditary factors are active in the development of these tumors. We describe a group of six families, in each of which more than one member had glioma, and discuss the probable mechanisms of oncogenesis in familial tumors in light of the pertinent literature.
authors.affiliation: Department of Neurosurgery-INM Neuromed IRCCS, Pozzilli (Is), Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Caroli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Salvati
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Peruzzi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Frati
authors.forename: Felice
authors.initials: F
authors.lastname: Giangaspero
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis / Q000209:etiology*; D004777:Environment; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D040582:Inheritance Patterns; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013577:Syndrome