title: A revised day +7 predictive score for transplant-related mortality: serum cholinesterase, total protein, blood urea nitrogen, gamma glutamyl transferase, donor type and cell dose.
abstract: We have previously described a scoring system for patients undergoing hemopoietic stem cell transplantation (HSCT) based on day +7 blood urea nitrogen (BUN) and serum bilirubin levels. We have revised that scoring system using a formal multivariate approach based on a training phase (305 patients) and a validation phase (217 patients). Day +7 BUN, serum cholinesterase (CHE), total proteins (TP), gamma glutamyl transferase (gammaGT), donor type and cell dose at transplant were included in the new score. The score distribution identified three groups of patients in the training set (<25, 25-75, >75 percentile of the score) which were classified as low, intermediate and high risk. Their actuarial risk of transplant-related mortality (TRM) at 6 years was, respectively, 12, 38 and 60%. In the validation set the 6 year actuarial TRM was, respectively, 15, 40 and 69%. High risk patients had more graft-versus-host disease (GvHD) (P <0.0001) and lower platelet counts (P <0.0001). This study confirms that GvHD and TRM can be predicted on day +7 after HSCT: pre-emptive GvHD therapy may be one option for high-risk patients and is being tested in a prospective randomized trial. The score for single patients can be calculated on the web site http://213.26.110.20/lrm/day_seven_score.html.
authors.affiliation: Unitá Epidemiologia Clinica, Istituto Scientifio Tumori, Genoa, Italy.
authors.forename: M P
authors.initials: MP
authors.lastname: Sormani
authors.forename: R
authors.initials: R
authors.lastname: Oneto
authors.forename: B
authors.initials: B
authors.lastname: Bruno
authors.forename: M
authors.initials: M
authors.lastname: Fiorone
authors.forename: T
authors.initials: T
authors.lastname: Lamparelli
authors.forename: F
authors.initials: F
authors.lastname: Gualandi
authors.forename: A M
authors.initials: AM
authors.lastname: Raiola
authors.forename: A
authors.initials: A
authors.lastname: Dominietto
authors.forename: M T
authors.initials: MT
authors.lastname: Van Lint
authors.forename: F
authors.initials: F
authors.lastname: Frassoni
authors.forename: P
authors.initials: P
authors.lastname: Bruzzi
authors.forename: A
authors.initials: A
authors.lastname: Bacigalupo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001806:Blood Urea Nitrogen; D002452:Cell Count; D002802:Cholinesterases / Q000097:blood; D005260:Female; D006402:Hematologic Diseases / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011237:Predictive Value of Tests; D011379:Prognosis; D011506:Proteins / Q000032:analysis; D012720:Severity of Illness Index; D015996:Survival Rate; D014019:Tissue Donors; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D011506:Proteins; D005723:gamma-Glutamyltransferase; D002802:Cholinesterases