title: [The expression and activity of caspase-8 in the process of vitamin E succinate-induced apoptosis in human gastric carcinoma SGC-7901 cells].
abstract: OBJECTIVE
  To investigate the role of caspase-8 in vitamin E succinate (VES)-induced apoptosis in human gastric carcinoma cells.
  
  
  METHODS
  The expression and activity of caspase-8 were measured by the Western Blot method with fluorescence and DAPI staining.
  
  
  RESULTS
  VES treatment induced the expression and activity of caspase-8 in a dose-dependent manner; the apoptosis ratio induced by VES was significantly decreased in SGC-7901 cells treated with caspase-8 inhibitor.
  
  
  CONCLUSIONS
  Caspase-8 plays an important role in SGC-7901 cell apoptosis induced by VES.
authors.affiliation: Nutrition and Food Department, Public Health College of Harbin Medical University, Harbin 150001, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Li
authors.forename: Kun
authors.initials: K
authors.lastname: Wu
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Yu
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D053181:Caspase 8; D020169:Caspases / Q000378:metabolism* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D013274:Stomach Neoplasms / Q000201:enzymology / Q000473:pathology*; D024505:Tocopherols; D014407:Tumor Cells, Cultured; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D014810:Vitamin E; C505530:CASP8 protein, human; D053181:Caspase 8; D020169:Caspases; D024505:Tocopherols