title: Cell growth inhibitory effect of cinnamic acid derivatives from propolis on human tumor cell lines.
abstract: A cell growth inhibitory effect of drupanin and baccharin, ingredients of propolis, was found in human cancer cell lines. These compounds induced apoptosis in the cells characterized by morphological and nucleosomal DNA fragmentation analysis. Their effects were less potent compared with that of artepillin C, which is a known anticancer compound from propolis. Importantly, HL60 cells were more sensitive to drupanin than were Con A-stimulated peripheral blood lymphocytes, whereas the potency of artepillin C was the opposite of that of drupanin.
authors.affiliation: Gifu International Institute of Biotechnology, Kakamigahara, Japan. yakao@giib.or.jp
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Akao
authors.forename: Hiroe
authors.initials: H
authors.lastname: Maruyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohguchi
authors.forename: Kumi
authors.initials: K
authors.lastname: Nishizawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Yoko
authors.initials: Y
authors.lastname: Araki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mishima
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nozawa
mesh_terms: D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011429:Propolis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D002934:Cinnamates; D006131:Growth Inhibitors; D010936:Plant Extracts; C029010:cinnamic acid; D011429:Propolis