title: Analysis of cDNAs coding for immunologically dominant antigens from an oncosphere-specific cDNA library of Echinococcus multilocularis.
abstract: A cDNA library based on mRNA from oncospheres of Echinococcus multilocularis was constructed and screened with an oncosphere-specific rabbit serum. cDNA sequences of three clones that were isolated out of this library are discussed: one codes for a serpin-like proteinase inhibitor, the first isolated from cestodes. Two other clones code for dominant oncosphere antigens and represent homologues of known genes: one is known from several taeniid cestodes as a protective antigen containing fibronectin III domains, the second is related to genes of small heat shock proteins. It contains an internal duplication that might be specific for platyhelminths.
authors.affiliation: Department of Parasitology, University of Hohenheim, 70599 Stuttgart, Germany. om6@ix.urz.uni-heidelberg.de
authors.forename: Armin
authors.initials: A
authors.lastname: Merckelbach
authors.forename: Martina
authors.initials: M
authors.lastname: Wager
authors.forename: Richard
authors.initials: R
authors.lastname: Lucius
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000947:Antigens, Helminth / Q000235:genetics* / Q000276:immunology; D001483:Base Sequence; D003001:Cloning, Molecular; D004446:Echinococcus / Q000235:genetics* / Q000276:immunology; D015723:Gene Library; D005799:Genes, Dominant / Q000276:immunology; D015151:Immunoblotting; D008969:Molecular Sequence Data
chemical_list: D000947:Antigens, Helminth