title: Extragastrointestinal stromal tumor of the greater omentum: case report and review of the literature.
abstract: Primary neoplasms of the greater omentum are rare. We report a case of omental tumors occurring in 58-year-old Japanese man. Ultrasonography showed multiple solid tumors in the abdomen and angiography identified the greater omentum as the precise location. The tumors were completely resected with the major part of the greater omentum and analyzed histologically, immunohistochemically, and genetically. Positive reactivity for CD117 (c-kit, a transmembrane tyrosine kinase receptor) and CD34, and the absence of TLS/FUS-CHOP rearrangement confirmed that the tumors were extragastrointestinal counterparts of a gastrointestinal stromal tumor. Although the higher mitotic activity measured by the Ki-67 labeling ratio suggests the malignant potential of this tumor, there was no recurrence at the 20-month follow-up.
authors.affiliation: Department of Surgery, Hiratsuka City Hospital, 1-19-1 Minamihara, Hiratsuka, Kanagawa, Japan, 2540065. MoMaMeJu@aol.com
authors.forename: Motohito
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Yoshikiyo
authors.initials: Y
authors.lastname: Akasaka
authors.forename: Toshio
authors.initials: T
authors.lastname: Kanai
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Yamashita
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kuroda
authors.forename: Hideaki
authors.initials: H
authors.lastname: Takayama
authors.forename: Naoto
authors.initials: N
authors.lastname: Miyazawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D018301:Neoplasms, Mesothelial / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D009852:Omentum / Q000473:pathology / Q000601:surgery*; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit