Changes in synaptic properties in cortical-limbic communications induced by repeated treatments with fluvoxamine in rats.
There is evidence indicating that dysregulation of coordinated interactions of the cortical-limbic circuitry is associated with anxiety and mood disorders. Our previous study has reported that an enhancement of long-term plasticity in the "limbic-cortical" pathway produced by repeated treatments with fluvoxamine may be involved in the clinical effects of a selective serotonin (5-HT) reuptake inhibitor (SSRI). Here we assessed the effects of single and repeated treatments with fluvoxamine on the synaptic transmission and plasticity in the "cortical-limbic" pathway in vivo. The evoked potentials in the basolateral amygdaloid complex (BLA) by stimulation of the medial prefrontal cortex (mPFC) in halothane-anesthetized rats were recorded. Single administration of fluvoxamine (10 and 30 mg/kg, i.p.) enhanced the efficacy of synaptic transmission at the mPFC-BLA synapses dose-dependently. The enhanced synaptic efficacy induced by 30 mg/kg fluvoxamine was suppressed after long-term administration of fluvoxamine (30 mg/kg per day x 21 days, orally). Repeated treatments with fluvoxamine affected short-term, but not long-term, synaptic plasticity in the mPFC-BLA pathway. These findings indicate that the 5-HTergic system contributes to modulation of synaptic changes in this pathway. Our results also suggest that different changes in synaptic properties in cortical-limbic communications induced by repeated treatments with fluvoxamine may be associated with therapeutic effects of SSRI.
Ohashi
Satoshi
S
Department of Pharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Togashi
Hiroko
H
Matsumoto
Machiko
M
Mori
Kiyoshi
K
Ueno
Ken-Ichi
K
Yoshioka
Mitsuhiro
M
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D016666:Fluvoxamine / Q000008:administration & dosage*; D008032:Limbic System / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
D016666:Fluvoxamine