title: BOLD and perfusion response to finger-thumb apposition after acetazolamide administration: differential relationship to global perfusion.
abstract: The authors studied the effects of altering global cerebral blood flow on both blood oxygen level-dependent (BOLD) response and perfusion response to finger-thumb apposition. A PICORE/QUIPSS II protocol was used to collect interleaved BOLD-weighted and perfusion-weighted images on eight finger-thumb apposition trials. Subjects were studied on a drug-free day and on a day when acetazolamide was administered between the second and third trials. After acetazolamide administration, resting cortical perfusion increased an average of 20% from preadministration levels, whereas the BOLD response to finger-thumb apposition decreased by an average of 35% in the S1M1 hand area. Contrary to predictions from the exhausted cerebrovascular reserve hypothesis and the oxygen limitation model, an effect of acetazolamide on cerebral blood flow response in the S1M1 hand area was not observed. Across the acetazolamide trials, BOLD response was inversely correlated with resting cortical perfusion for individual subject data. These results suggest that resting perfusion affects the magnitude of the BOLD response and is thus an important confounding factor in fMRI studies, and that the physiologic systems that increase cerebral blood flow in response to acetazolamide administration and systems that increase cerebral blood flow in response to altered neural activity appear to have additive effects.
authors.affiliation: VA San Diego Healthcare System, San Diego, California 92161, USA.
authors.forename: Gregory G
authors.initials: GG
authors.lastname: Brown
authors.forename: Lisa T
authors.initials: LT
authors.lastname: Eyler Zorrilla
authors.forename: Bassem
authors.initials: B
authors.lastname: Georgy
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Kindermann
authors.forename: Eric C
authors.initials: EC
authors.lastname: Wong
authors.forename: Richard B
authors.initials: RB
authors.lastname: Buxton
mesh_terms: D000086:Acetazolamide / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D001921:Brain / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D005385:Fingers; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010100:Oxygen / Q000097:blood*; D012039:Regional Blood Flow / Q000187:drug effects*; D013933:Thumb
chemical_list: D000086:Acetazolamide; D010100:Oxygen