From nitric oxide to endothelial cytosolic Ca2+: a negative feedback control.
Nitric oxide production is stimulated by an increase of the concentration of cytosolic Ca(2+) in vascular endothelial cells. Recent evidence suggests that nitric oxide and cGMP might attenuate Ca(2+) influx and, at the same time, initiate a Ca(2+) removal mechanism, thereby decreasing the intracellular concentration of endothelial Ca(2+) in a negative feedback fashion. Such a negative feedback mechanism could serve to protect the endothelial cells from the detrimental effects of excessive nitric oxide and Ca(2+).
Yao
Xiaoqiang
X
Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China. yao2068@cuhk.edu.hk
Huang
Yu
Y
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D025461:Feedback, Physiological; D006801:Humans; D009569:Nitric Oxide / Q000096:biosynthesis / Q000378:metabolism*; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases
D009569:Nitric Oxide; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D000252:Calcium-Transporting ATPases; D006152:Cyclic GMP; D002118:Calcium