Neurotoxicity of some MAO inhibitors in adult rat hypothalamic cell culture.
Monoamine oxidase-A (MAO-A) [amiflamine (AMF) and 4-methylthioamphetamine (MTA)] and MAO-B (L-deprenyl) inhibitors were found to be cytotoxic in a concentration-dependent manner for RCHT cells derived from adult rat hypothalamus. The cytotoxic effects were increased when the inhibitors were co-incubated with dicoumarol and especially with 25 micro M AMF+100 micro M dicoumarol (2.5-fold; P <0.001). The treatment of RCHT cells solely with AMF induced a marked decrease in the expression of DT-diaphorase mRNA.
Hurtado-Guzmán
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Department of Chemistry, Faculty of Sciences, Millennium Institute for Cell Biology and Biotechnology, University of Chile, Santiago, Chile. jsegura@machi.med.uchile.cl
Martínez-Alvarado
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P
Dagnino-Subiabre
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A
Paris
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I
Caviedes
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P
Caviedes
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R
Cassels
B K
BK
Segura-Aguilar
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J