In vivo degradation characteristics of poly(glycerol sebacate).
We have developed a series of biodegradable elastomers, poly(glycerol sebacate) (PGS), based on glycerol and sebacic acid. The polymers are potentially useful in soft tissue regeneration and engineering. To evaluate the performance of PGS in a physiological environment, we compared their degradation profiles with poly(DL-lactide-co-glycolide) (50:50, carboxyl ended, M(w) 15,000) in vivo. Among the parameters examined are changes in weight and mechanical strength with time, implant geometry, surface characteristics, and degree of swelling. Unlike poly(DL-lactide-co-glycolide), PGS primarily degrades by surface erosion, which gives a linear degradation profile of mass, preservation of geometry and intact surface, and retention of mechanical strength.
Wang
Yadong
Y
Department of Chemical Engineering, 77 Massachusetts Avenue, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Kim
Yu Mi
YM
Langer
Robert
R
D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism*; D001673:Biodegradation, Environmental; D019245:Compressive Strength; D003651:Decanoates / Q000378:metabolism*; D005260:Female; D005990:Glycerol / Q000031:analogs & derivatives / Q000378:metabolism*; D006016:Glycolates / Q000378:metabolism; D019344:Lactic Acid; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013499:Surface Properties; D023822:Tissue Engineering
D001672:Biocompatible Materials; D003651:Decanoates; D006016:Glycolates; D011108:Polymers; C469892:poly(glycerol-sebacate); D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005990:Glycerol