[Antiviral activity of some 5-arylethynyl 2'-deoxyuridine derivatives].
5-(3-Perylenylethynyl)-2'-deoxyuridine was prepared by cross-linking 5-iodo-2'-deoxyuridine derivatives with 3-ethynylperylene followed by deprotection. 5-(1-Perylenylethynyl)-, 5-(3-perylenylethynyl)-, and 5-[4-(2-benzoxazolyl)phenylethynyl]-2'-deoxyuridine were found to inhibit in Vero cells the replication of type 1 herpes simplex virus and its drug-resistant strains.
Andronova
V L
VL
Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, ul. Gamalei 16, Moscow, 123098 Russia.
Skorobogatyĭ
M V
MV
Manasova
E V
EV
Berlin
Iu A
IuA
Korshun
V A
VA
Galegov
G A
GA
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D002478:Cells, Cultured; D002625:Chemistry, Organic / Q000379:methods; D003432:Cross-Linking Reagents / Q000737:chemistry; D003857:Deoxyuridine / Q000031:analogs & derivatives / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D024921:Drug Resistance, Multiple, Viral; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000502:physiology; D007668:Kidney / Q000166:cytology / Q000187:drug effects / Q000821:virology; D010569:Perylene / Q000031:analogs & derivatives / Q000737:chemistry; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D003432:Cross-Linking Reagents; D010569:Perylene; D003857:Deoxyuridine