title: [Corneal graft rejection and corticoid iontophoresis: 3 case reports].
abstract: This is the first report of three cases of severe acute corneal graft rejection, treated by transscleral methylprednisolone (Solumédrol) iontophoresis. The efficacy of the treatment was evaluated by corneal transparency, visual acuity and corneal inflammation parameters. The patient was treated with Solumédrol iontophoresis once a day for 3 days with a topical corticotherapy reduced to three drops of dexamethasone per day. Iontophoresis was performed, under topical anesthesia, and lasted 3 minutes with a 1.5-mA current. The subjective and objective tolerance of iontophoresis was good. No side-effect was observed. Corneal transparency and visual acuity improved rapidly after the second iontophoresis procedure. These observations show that Solumédrol iontophoresis might be an alternative to pulse therapy in the treatment of corneal graft rejection. Further comparative studies are necessary to confirm these preliminary observations.
authors.affiliation: Service d'ophtalmologie, Hôpital Hôtel-Dieu, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Halhal
authors.forename: G
authors.initials: G
authors.lastname: Renard
authors.forename: R A
authors.initials: RA
authors.lastname: Bejjani
authors.forename: F
authors.initials: F
authors.lastname: Behar-Cohen
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016039:Corneal Transplantation; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D007478:Iontophoresis; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D012590:Sclera; D014792:Visual Acuity
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D008775:Methylprednisolone