Ribosomal mutations conferring resistance to macrolides in Streptococcus pneumoniae clinical strains isolated in Germany.
Among a collection of 4281 pneumococcal isolates, 7 strains isolated in Germany had an unusual macrolide resistance phenotype. The isolates were found to have multiple mutations in the 23S rRNA and alterations in the L4 ribosomal protein. One strain had an amino acid alteration in the L22 ribosomal protein.
Reinert
Ralf René
RR
Institute of Medical Microbiology, National Reference Center for Streptococci, Aachen, Germany. reinert@rwth-aachen.de
Wild
Angela
A
Appelbaum
Peter
P
Lütticken
Rudolf
R
Cil
Murat Yücel
MY
Al-Lahham
Adnan
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005838:Genotype; D005858:Germany; D018942:Macrolides; D008969:Molecular Sequence Data; D017354:Point Mutation; D012338:RNA, Ribosomal, 23S / Q000235:genetics*; D012269:Ribosomal Proteins / Q000235:genetics*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics*
D000900:Anti-Bacterial Agents; D018942:Macrolides; D012338:RNA, Ribosomal, 23S; D012269:Ribosomal Proteins; C056368:ribosomal protein L4