title: Effects of weaning cereals with different phytate contents on hemoglobin, iron stores, and serum zinc: a randomized intervention in infants from 6 to 12 mo of age.
abstract: BACKGROUND
  Weaning foods frequently contain phytate, an inhibitor of iron and zinc absorption, which may contribute to the high prevalence of iron and zinc deficiency seen in infancy.
  
  
  OBJECTIVE
  The objective was to investigate whether either an extensive reduction in the phytate content of infant cereals or the use of milk-based, iron-fortified infant formula would improve iron and zinc status in infants.
  
  
  METHODS
  In a double-blind design, infants (n = 300) were randomly assigned to 3 cereal groups from 6 to 12 mo of age: commercial milk-based cereal drink (MCD) and porridge (CC group), phytate-reduced MCD and phytate-reduced porridge (PR group), or milk-based infant formula and porridge with the usual phytate content (IF group). Venous blood samples were collected at 6 and 12 mo. Dietary intake was recorded monthly. After the intervention, 267 infants remained in the analysis.
  
  
  RESULTS
  Hemoglobin concentrations of < 110 g/L, serum ferritin concentrations of < 12 microg/L, and serum zinc concentrations of < 10.7 micromol/L had overall prevalences at baseline and 12 mo of 28% and 15%, 9% and 18%, and 22% and 27%, respectively. After the intervention, there were no significant differences in any measure of iron or zinc status between the CC and the PR groups. However, hemoglobin was significantly higher (120 g/L compared with 117 g/L; P = 0.012) and the prevalence of anemia was lower (13% compared with 23%; P = 0.06) in the PR group than in the IF group, which could be explained by differences in daily iron intake between the 2 groups.
  
  
  CONCLUSIONS
  Extensive reduction in the phytate content of weaning cereals had little long-term effect on the iron and zinc status of Swedish infants.
authors.affiliation: Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden. torbjorn.lind@epiph.umu.se
authors.forename: Torbjörn
authors.initials: T
authors.lastname: Lind
authors.forename: Bo
authors.initials: B
authors.lastname: Lönnerdal
authors.forename: Lars-Ake
authors.initials: LA
authors.lastname: Persson
authors.forename: Hans
authors.initials: H
authors.lastname: Stenlund
authors.forename: Catharina
authors.initials: C
authors.lastname: Tennefors
authors.forename: Olle
authors.initials: O
authors.lastname: Hernell
mesh_terms: D000740:Anemia / Q000453:epidemiology; D004032:Diet; D004311:Double-Blind Method; D002523:Edible Grain / Q000737:chemistry*; D005293:Ferritins / Q000097:blood; D005527:Food, Fortified; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000032:analysis; D007501:Iron / Q000008:administration & dosage / Q000097:blood*; D010833:Phytic Acid / Q000032:analysis*; D015995:Prevalence; D014886:Weaning; D015032:Zinc / Q000097:blood*
chemical_list: D006454:Hemoglobins; D010833:Phytic Acid; D005293:Ferritins; D007501:Iron; D015032:Zinc