The role of TGF-beta 1 in mice hepatic fibrosis by Schistosomiasis Japonica.
To investigate the role of transforming growth factor-beta 1 (TGF-beta 1) in mice with hepatic fibrosis caused by Schistosomiasis Japonica, ELISA, VG staining and multimedia color hieroglyph quantitative analysis were used to study the change of the serum TGF-beta 1, liver collagen fiber and reticular fiber in mice. The level of serum TGF-beta 1 in experimental group was significantly higher than that in control group (P < 0.01 or P < 0.05) 8, 10, 12 weeks after infected by schistosomiasis. After infection, the level of liver collagen fiber and reticular fiber, and that of TGF-beta 1 increased over time (P < 0.01 or P < 0.05). In mice infected by Schistosomiasis Japonica, the level of TGF-beta 1 increased with prolongation of infection time, and with the increase of liver collagen fiber and reticular fiber. TGF beta 1 plays an important role of immunomodulation in hepatic fibrosis formation caused by Schistosomiasis Japonica.
Zhu
H
H
Department of Infectious Disease, Xiehe Hospital, Tongji Medical University, Wuhan 430022.
Zeng
L
L
Zhu
D
D
Yuan
Y
Y
D000818:Animals; D003094:Collagen / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008106:Liver Cirrhosis, Experimental / Q000097:blood* / Q000209:etiology; D051379:Mice; D011897:Random Allocation; D012155:Reticulin / Q000378:metabolism; D012554:Schistosomiasis japonica / Q000097:blood / Q000150:complications*; D016212:Transforming Growth Factor beta / Q000097:blood* / Q000502:physiology; D053773:Transforming Growth Factor beta1
D012155:Reticulin; C508961:Tgfb1 protein, mouse; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D003094:Collagen