title: Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae.
abstract: Leptin is a pleiotropic hormone-cytokine known to regulate energy homeostasis and immune function. Neutrophils from leptin-deficient mice exhibited impaired phagocytosis of Klebsiella pneumoniae opsonized with serum containing complement and reduced CD11b expression that could be restored with exogenous leptin. These results suggest that leptin is required for normal neutrophil complement-mediated phagocytosis of bacteria.
authors.affiliation: Program in Human Nutrition, University of Michigan, Ann Arbor, Michigan 48109, USA.
authors.forename: Sharlene I
authors.initials: SI
authors.lastname: Moore
authors.forename: Gary B
authors.initials: GB
authors.lastname: Huffnagle
authors.forename: Gwo-Hsiao
authors.initials: GH
authors.lastname: Chen
authors.forename: Eric S
authors.initials: ES
authors.lastname: White
authors.forename: Peter
authors.initials: P
authors.lastname: Mancuso
mesh_terms: D000818:Animals; D039481:CD11b Antigen / Q000032:analysis; D005260:Female; D007711:Klebsiella pneumoniae / Q000276:immunology*; D020738:Leptin / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D017452:Receptors, IgG / Q000032:analysis; D054411:Receptors, Leptin
chemical_list: D039481:CD11b Antigen; D020738:Leptin; D017452:Receptors, IgG; D054411:Receptors, Leptin; C515447:leptin receptor, mouse