Susceptibility to rifaximin of Vibrio cholerae strains from different geographical areas.
Four hundred and eight clinical strains of Vibrio cholerae isolated from different geographical areas and with different antimicrobial resistance patterns were tested for susceptibility to rifaximin, a non-absorbable antibiotic active in vitro against Gram-negative bacteria. The MICs ranged from 0.5 to 4 mg/l for all strains. These values and the pharmacokinetic properties suggest rifaximin as an attractive antimicrobial agent for cholera.
Scrascia
Maria
M
Dipartimento di Anatomia Patologica e di Genetica, Sezione di Genetica, Università di Bari, Via G. Amendola 165/A, 70126 Bari, Italy.
Forcillo
Maria
M
Maimone
Francesco
F
Pazzani
Carlo
C
D000349:Africa; D002489:Central America; D024881:Drug Resistance, Bacterial / Q000502:physiology*; D005060:Europe; D006801:Humans; D008826:Microbial Sensitivity Tests; D012294:Rifamycins / Q000494:pharmacology*; D000078262:Rifaximin; D013020:South America; D014734:Vibrio cholerae / Q000187:drug effects* / Q000302:isolation & purification*
D012294:Rifamycins; D000078262:Rifaximin