Antioxidative glycosides from the leaves of Ligustrum robustum.
Phytochemical investigation of the ethanol extract of the leaves of Ligustrum robustum, monitored by a bioassay involving the hemolysis of red blood cells induced by 2,2'-azo-bis(2-amidinopropane) dihydrochloride, led to the isolation of three new glycosides, ligurobustosides M (1), N (2), and O (3), along with 10 known ones, osmanthuside B (4), osmanthuside B6 (5), acteoside (6), ligupurpuroside A (7), ligupurpuroside B (8), ligurobustoside C (9), ligurobustoside E (10), ligurobustoside I (11), cosmosiin (12), and rhoifolin (13). The structures of the new compounds were elucidated by spectroscopic methods. Seven of the glycosides showed stronger antioxidant effects than the standard, trolox.
He
Zhen-Dan
ZD
Department of Biology, The Chinese University of Hong Kong, Shatin, Hong Kong, People's Republic of China.
Lau
Kit-Man
KM
But
Paul Pui-Hay
PP
Jiang
Ren-Wang
RW
Dong
Hui
H
Ma
Shuang-Cheng
SC
Fung
Kwok-Pui
KP
Ye
Wen-Cai
WC
Sun
Han-Dong
HD
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002839:Chromans / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D031659:Ligustrum / Q000737:chemistry*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D000975:Antioxidants; D002839:Chromans; D004365:Drugs, Chinese Herbal; D006027:Glycosides; C478725:ligurobustoside M; C478726:ligurobustoside N; C478727:ligurobustoside O; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid