Etiopathogenesis of cholesteatoma.
Cholesteatoma is a destructive lesion of the temporal bone that gradually expands and causes complications by erosion of the adjacent bony structures. Bone resorption can result in destruction of the ossicular chain and otic capsule with consecutive hearing loss, vestibular dysfunction, facial paralysis and intracranial complications. Surgery is the only treatment of choice. The etiopathogenesis of cholesteatoma, however, is still controversial. This review was designed to understand the reasons for these disparities and to reduce or eliminate them. Future studies focused on developmental, epidemiological, hormonal and genetic factors as well as on treatment are likely to contribute to further understanding of cholesteatoma pathogenesis.
Olszewska
Ewa
E
Department of Otorhinolaryngology and Head and Neck Surgery, Medical Academy, Bialystok, Poland.
Wagner
Mathias
M
Bernal-Sprekelsen
Manuel
M
Ebmeyer
Jörg
J
Dazert
Stefan
S
Hildmann
Henning
H
Sudhoff
Holger
H
D000943:Antigens, Differentiation / Q000235:genetics; D017209:Apoptosis; D001862:Bone Resorption; D002453:Cell Cycle; D018424:Cholesteatoma, Middle Ear / Q000145:classification / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology*; D016207:Cytokines / Q000378:metabolism; D005109:Extracellular Matrix / Q000235:genetics / Q000378:metabolism; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D050356:Lipid Metabolism; D008954:Models, Biological; D018919:Neovascularization, Physiologic / Q000502:physiology; D012106:Research; D014157:Transcription Factors / Q000235:genetics
D000943:Antigens, Differentiation; D016207:Cytokines; D006133:Growth Substances; D014157:Transcription Factors