title: Chlamydia pneumoniae in children with MS: frequency and quantity of intrathecal antibodies.
abstract: The authors investigated the frequency and quantity of intrathecal antibody synthesis against Chlamydia pneumoniae and the presence of C pneumoniae antigen in 25 children with MS. C pneumoniae genome was present in two children. In seven children an intrathecal synthesis of C pneumoniae antibodies was detected, representing only a small part of the total intrathecal immunoglobulin G, suggesting that this intrathecal synthesis is part of a polyspecific, oligoclonal immune response.
authors.affiliation: Department of Pediatric Neurology, University of Göttingen, Germany. Krostasy@excite.com
authors.forename: K
authors.initials: K
authors.lastname: Rostasy
authors.forename: H
authors.initials: H
authors.lastname: Reiber
authors.forename: D
authors.initials: D
authors.lastname: Pohl
authors.forename: P
authors.initials: P
authors.lastname: Lange
authors.forename: A
authors.initials: A
authors.lastname: Ohlenbusch
authors.forename: H
authors.initials: H
authors.lastname: Eiffert
authors.forename: M
authors.initials: M
authors.lastname: Maass
authors.forename: F
authors.initials: F
authors.lastname: Hanefeld
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid*; D000918:Antibody Specificity; D002555:Cerebrospinal Fluid / Q000276:immunology / Q000382:microbiology; D002648:Child; D023521:Chlamydophila Infections / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D016993:Chlamydophila pneumoniae / Q000276:immunology* / Q000302:isolation & purification; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D043025:Oligoclonal Bands