title: Synthesis of 3-hexahelicenol and its transformation to 3-hexahelicenylamines, diphenylphosphine, methyl carboxylate, and dimethylthiocarbamate.
abstract: A nonphotochemical synthetic route to 3-hexahelicenol is reported. It involves a key [2+2+2] cycloisomerization of CH(3)O-substituted triyne that is readily available from 1-methoxy-3-methylbenzene and 1-bromo-2-(bromomethyl)naphthalene. Further functional group transformations led to 3-CO(2)CH(3), 3-NH(2), 3-PPh(2), and 3-SC(O)N(CH(3))(2) substituted hexahelicenes.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám 2, 166 10 Prague 6, Czech Republic.
authors.forename: Filip
authors.initials: F
authors.lastname: Teplý
authors.forename: Irena G
authors.initials: IG
authors.lastname: Stará
authors.forename: Ivo
authors.initials: I
authors.lastname: Starý
authors.forename: Adrian
authors.initials: A
authors.lastname: Kollárovic
authors.forename: David
authors.initials: D
authors.lastname: Saman
authors.forename: Stepán
authors.initials: S
authors.lastname: Vyskocil
authors.forename: Pavel
authors.initials: P
authors.lastname: Fiedler