Liver disease in alcohol and hepatitis C.
The prevalence of hepatitis C is 7-10-fold higher in alcoholics than it is in the general population. Among alcoholics, the prevalence of hepatitis C is higher in alcoholics with advanced liver disease. Serum ALT and hepatitis C viral load may improve if alcoholic patients with hepatitis C stop drinking for more than 4 months.Up to 60% of patients with hepatitis C have a past history of alcohol use. In patients with hepatitis C, chronic alcohol consumption of more than 5 drinks per day increases the rate of liver fibrosis. Hepatitis C patients who ingest more than 5 alcoholic drinks per day are at increased risk for cirrhosis, hepatocellular carcinoma and, possibly, death from liver disease. Recent alcohol use decreases the response rate to interferon treatment. The detrimental effects of small amounts (3 or fewer drinks per day) of alcohol consumption in patients with hepatitis C are not known.
Jamal
M Mazen
MM
Division of Gastroenterology and Hepatology, VA Medical Center, 5901 E. Seventh Street-111, Long Beach, CA 90822, USA. jamal@uci.edu
Morgan
Timothy R
TR
D000428:Alcohol Drinking / Q000009:adverse effects* / Q000453:epidemiology; D000437:Alcoholism / Q000453:epidemiology*; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology; D015897:Comorbidity; D019698:Hepatitis C, Chronic / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000209:etiology; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D012306:Risk; D012720:Severity of Illness Index; D019562:Viral Load
D007372:Interferons