Effect of hydrotalcite-like compounds on the aqueous solubility of some poorly water-soluble drugs.
A new approach of improving drug dissolution properties is described. This method exploits the property of a carrier owing to the hydrotalcite-type anionic clays (HTlc). HTlc is an inorganic layered solid that lodges anionic compounds among its layers. As HTlc dissolves at acidic pH values (pH < 4), the anions intercalated among the layers are promptly released in the medium. In this article some nonsteroidal antiinflammatory drugs were chosen as models of poorly water-soluble drugs. They were intercalated in HTlc and solubility measurements in acidic medium were performed. A remarkable improvement of drug solubility was observed especially in the case of indomethacin.
Ambrogi
Valeria
V
Dipartimento di Chimica e Tecnologia del Farmaco, via del Liceo 1, University of Perugia, 06123 Perugia, Italy.
Fardella
Giuseppe
G
Grandolini
Giuliano
G
Nocchetti
Morena
M
Perioli
Luana
L
D000536:Aluminum Hydroxide / Q000032:analysis* / Q000737:chemistry; D008276:Magnesium Hydroxide / Q000032:analysis* / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry; D012995:Solubility / Q000187:drug effects; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013818:Thermogravimetry / Q000379:methods; D014867:Water / Q000032:analysis* / Q000737:chemistry
D004364:Pharmaceutical Preparations; D014867:Water; C010467:hydrotalcite; D000536:Aluminum Hydroxide; D008276:Magnesium Hydroxide