B-scan ultrasonography for the detection of macular thickening.
OBJECTIVE
To report the sensitivity and specificity of B-scan ultrasonography to detect macular thickening.


METHODS
Observational case series.


METHODS
Seventy-seven eyes of 40 consecutive patients (age range, 7-80 years) in a retinal specialty practice were examined. A single masked ultrasound operator performed B-scan ultrasonography on all eyes and graded macular thickening. The final assessment of macular thickening was based on biomicroscopy findings combined with fluorescein angiography (FA) and optical coherence tomography (OCT). The presence or absence of macular thickening as determined by B-scan ultrasonography was compared with the final clinical assessment, FA findings, and OCT measurements.


RESULTS
B-scan ultrasonography detected macular thickening with a high degree of sensitivity (91%) and specificity (96%). There was a high degree of agreement between findings on ultrasonography and FA (kappa = 0.80). Ultrasonographic diagnosis correlated with OCT measurements for both central macular thickness (r =.65, P <.001) and volume (r =.56, P <.001).


CONCLUSIONS
Ultrasonographic detection of macular thickening correlates with findings on slit-lamp biomicroscopy, FA, and OCT. B-scan ultrasonography is a potentially useful technique for assessing macular thickness when biomicroscopy is impossible or when patients cannot tolerate FA or OCT.
Lai
James C
JC
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Stinnett
Sandra S
SS
Jaffe
Glenn J
GJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007368:Interferometry / Q000379:methods; D008266:Macula Lutea / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000000981:diagnostic imaging*; D012680:Sensitivity and Specificity; D014054:Tomography / Q000379:methods; D014463:Ultrasonography