title: [The development of the nervous system: from fly to fish, from fish to man....].
abstract: The nervous system of vertebrates is more complex and less tractable than that of current model organisms such as the fly and the nematode. Here we present a vertebrate sensory system which is structurally simple, experimentally accessible and genetically suitable: the lateral line of the zebra-fish. We review our recent work on the development of this system, with a particular emphasis on the migration events that shape the pattern of sense organs. Some of the factors involved in these migration events turn out to be similar to the factors that direct the formation of metastases in specific types of human cancers, illustrating once again the remarkable conservation of developmental mechanisms and genes throughout the animal kingdom.
authors.affiliation: Laboratoire de Neurogénétique, Inserm E343, cc103, Université de Montpellier II, place E. Bataillon, 34095 Montpellier, France. aghysen@univ-montp2.fr
authors.forename: Alain
authors.initials: A
authors.lastname: Ghysen
authors.forename: Christine
authors.initials: C
authors.lastname: Dambly-Chaudière
mesh_terms: D000825:Animal Structures / Q000196:embryology; D000818:Animals; D002465:Cell Movement; D004331:Drosophila melanogaster / Q000196:embryology; D004625:Embryo, Nonmammalian / Q000166:cytology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008954:Models, Biological; D009024:Morphogenesis; D009362:Neoplasm Metastasis; D009474:Neurons / Q000166:cytology; D009928:Organ Specificity; D019718:Receptors, CXCR4 / Q000502:physiology; D012679:Sense Organs / Q000166:cytology / Q000196:embryology*; D013045:Species Specificity; D014714:Vertebrates / Q000196:embryology; D015027:Zebrafish / Q000196:embryology*
chemical_list: D019718:Receptors, CXCR4