The neurocognitive effects of radiation in adult low-grade glioma patients.
Radiotherapy is a component of the treatment regimen for the majority of patients with low-grade gliomas. Therefore, the effect of radiotherapy on the long-term cognitive performance of these patients is a major concern. This article reviews the neurocognitive effects of radiotherapy on patients with low-grade gliomas. The weight of evidence suggests only sporadic, limited neurocognitive damage from focal radiotherapy at the doses usually prescribed for low-grade gliomas.
Brown
Paul D
PD
Division of Radiation Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. brown.paul@mayo.edu
Buckner
Jan C
JC
Uhm
Joon H
JH
Shaw
Edward G
EG
D000328:Adult; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D003071:Cognition / Q000528:radiation effects*; D005910:Glioma / Q000532:radiotherapy*; D006801:Humans; D011878:Radiotherapy / Q000009:adverse effects