title: Establishment of standard values for the latency, interval and amplitude parameters of tibial nerve somatosensory evoked potentials (SEPs).
abstract: OBJECTIVE
  To establish standard values for tibial nerve somatosensory evoked potentials (SEPs).
  
  
  METHODS
  We examined SEPs following left tibial nerve stimulation in 65 normal subjects of various ages, and performed multiple regression analysis using height, age, (age-20)(2) and gender as predictor variables. We objectively selected the latency or interval parameters with less intersubject variability as the standard parameters for evaluation.
  
  
  RESULTS
  Among 3 cortical bipolar derivations investigated, the Cz'-Cc lead gave a more constant and stable P38 component than the Cz'-Fz or Ci-Cc lead. The latencies of the N8o (N8 onset) of the popliteal potential, P15 (P15 peak) in the contralateral iliac crest-ipsilateral greater trochanter lead, N21, N30 and P38o/P38 in the Cz'-Cc lead, as well as the intervals between these components were selected as standard parameters. P15 was easily identified in all of the subjects and is expected to be a new parameter to evaluate the proximal segment of the tibial nerve. The amplitudes of P15 and the other components were also evaluated. We present nomograms for the normal limit values of each parameter.
  
  
  CONCLUSIONS
  We present a thorough set of standard values for tibial SEPs where the subject factors were fully considered, and which is easily applicable to clinical practice.
authors.affiliation: Department of Neurology, Teikyo University School of Medicine, Kaga 2-11-1, Itabashi-ku 1738605, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Miura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sonoo
authors.forename: Teruo
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001827:Body Height; D004558:Electric Stimulation; D004569:Electroencephalography / Q000379:methods; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D011930:Reaction Time / Q000502:physiology*; D012016:Reference Values; D012044:Regression Analysis; D012737:Sex Factors; D013979:Tibial Nerve / Q000502:physiology*; D013997:Time Factors