Hypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus.
The hypolipidemic effect of an exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus was investigated in dietary-induced hyperlipidemic rats. Hypolipidemic effects were proportionally increased with the increasing concentration of the exo-biopolymer for oral administration. The exo-biopolymer, at the dose of 200 mg/kg body weight, substantially reduced the plasma total cholesterol (32.9%), LDL cholesterol (45.4%), triglyceride (34.3%), phospholipid (18.9%), atherogenic index (58.7%), and hepatic HMG-CoA reductase activity (20.2%). It increased the plasma HDL cholesterol level (31.1%) as compared to the control group. The molecular mass of this exo-biopolymer measured by HPLC was under 40 kDa. Total sugar and protein contents were 91.2 and 8.8%, respectively. The sugar and amino acid compositions of the exo-biopolymer were analyzed in detail.
Yang
Byung-Keun
BK
Department of Biotechnology, Research Center for Processing & Application of Agricultural Products, Daegu University, Kyungsan, Kyungbuk 712-714, South Korea.
Park
Jun-Bo
JB
Song
Chi-Hyun
CH
D000363:Agaricales / Q000737:chemistry* / Q000254:growth & development*; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001704:Biopolymers / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002241:Carbohydrates / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D006949:Hyperlipidemias / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D008970:Molecular Weight; D025282:Mycelium; D051381:Rats; D017207:Rats, Sprague-Dawley
D000596:Amino Acids; D001704:Biopolymers; D002241:Carbohydrates; D000960:Hypolipidemic Agents; D008055:Lipids; D006903:Hydroxymethylglutaryl CoA Reductases