title: Inflammatory myofibroblastic tumor with bone marrow involvement. A case report and review of the literature.
abstract: Inflammatory myofibroblastic tumor, also referred to as inflammatory fibrosarcoma, is a rare tumor composed of myofibroblastic spindle cells of uncertain etiology and disputed nosology. We report a case of inflammatory myofibroblastic tumor of the omentum with involvement of the bone marrow in an 18-year-old man. Histologic and immunohistochemical studies of the abdominal mass and bone marrow were consistent with inflammatory myofibroblastic tumor. Additionally, fluorescence in situ hybridization using a probe specific for the ALK gene showed disruption of the gene. The literature is reviewed with emphasis on the ability of inflammatory myofibroblastic tumor to recur, metastasize, and cause mortality.
authors.affiliation: Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Hagenstad
authors.forename: Scott E
authors.initials: SE
authors.lastname: Kilpatrick
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Pettenati
authors.forename: Paul D
authors.initials: PD
authors.lastname: Savage
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D019046:Bone Marrow Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology; D009379:Neoplasms, Muscle Tissue / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D009852:Omentum / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000235:genetics / Q000473:pathology / Q000601:surgery