title: Solution structure of Vibrio cholerae protein VC0424: a variation of the ferredoxin-like fold.
abstract: The structure of Vibrio cholerae protein VC0424 was determined by NMR spectroscopy. VC0424 belongs to a conserved family of bacterial proteins of unknown function (COG 3076). The structure has an alpha-beta sandwich architecture consisting of two layers: a four-stranded antiparallel beta-sheet and three side-by-side alpha-helices. The secondary structure elements have the order alphabetaalphabetabetaalphabeta along the sequence. This fold is the same as the ferredoxin-like fold, except with an additional long N-terminal helix, making it a variation on this common motif. A cluster of conserved surface residues on the beta-sheet side of the protein forms a pocket that may be important for the biological function of this conserved family of proteins.
authors.affiliation: Biological Sciences Division, Pacific Northwest National Laboratory, EMSL 2569 K8-98, 3335 Q Avenue, Richland, WA 99352, USA.
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Ramelot
authors.forename: Shuisong
authors.initials: S
authors.lastname: Ni
authors.forename: Sharon
authors.initials: S
authors.lastname: Goldsmith-Fischman
authors.forename: John R
authors.initials: JR
authors.lastname: Cort
authors.forename: Barry
authors.initials: B
authors.lastname: Honig
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kennedy
mesh_terms: D000595:Amino Acid Sequence; D005288:Ferredoxins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D016415:Sequence Alignment; D012996:Solutions; D014734:Vibrio cholerae / Q000737:chemistry*
chemical_list: D005288:Ferredoxins; D012996:Solutions