Synthesis and biological activity of cyclic ADP-carbocyclic-ribose and its analogs as stable mimics of Ca(2+)-mobilizing second messenger cyclic ADP-ribose.
Cyclic ADP-carbocyclic-ribose (cADPcR, 2) and its several analogs were designed and synthesized as stable mimics of Ca(2+)-mobilizing second messenger cyclic ADP-ribose (cADPR, 1). cADPcR was stable and actually caused a significant release of Ca(2+) stronger than that of cADPR.
Shuto
S
S
Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Kudoh
T
T
Fukuoka
M
M
Ueno
Y
Y
Matsuda
A
A
D000818:Animals; D020013:Calcium Signaling; D036563:Cyclic ADP-Ribose / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D010063:Ovum / Q000378:metabolism; D051381:Rats; D012617:Sea Urchins; D015290:Second Messenger Systems
C439996:cyclic ADP-carbocyclic-ribose; D036563:Cyclic ADP-Ribose