title: Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men.
abstract: Both rare germ-line mutations and common sequence variants of the macrophage scavenger receptor 1 (MSR1) gene have recently been implicated as potential prostate cancer susceptibility factors. However, existing studies are limited by the referral-based nature of samples and a paucity of African-American participants. In this context, we evaluated the association of germ-line mutations and common MSR1 sequence variants with prostate cancer risk in a case control study of a community-based sample of 134 African-American men with prostate cancer and 340 unaffected controls. In our sample, the rare Asp174Tyr missense change was identified nearly twice as frequently in men with prostate cancer (6.8%) compared with unaffected controls (3.6%; P = 0.14). Moreover, significantly different allele frequencies between cases and controls were observed for one of the sequence variants, IVS5-59 (P = 0.02). Taken together, our results provide some additional support for the hypothesis that selected, rare MSR1 mutations are associated with increased prostate cancer susceptibility among African-American men.
authors.affiliation: Department of Urology, University of Michigan, Medical School, Ann Arbor, Michigan 48109-0946, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Miller
authors.forename: S Lilly
authors.initials: SL
authors.lastname: Zheng
authors.forename: Rodney L
authors.initials: RL
authors.lastname: Dunn
authors.forename: Aruna V
authors.initials: AV
authors.lastname: Sarma
authors.forename: James E
authors.initials: JE
authors.lastname: Montie
authors.forename: Ethan M
authors.initials: EM
authors.lastname: Lange
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Meyers
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Xu
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Cooney
mesh_terms: D044383:Black People / Q000235:genetics*; D016001:Confidence Intervals; D005787:Gene Frequency; D018095:Germ-Line Mutation; D006720:Homozygote; D006801:Humans; D008297:Male; D008824:Michigan / Q000453:epidemiology; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*; D051116:Receptors, Scavenger; D012016:Reference Values; D012307:Risk Factors; D051117:Scavenger Receptors, Class A; D014481:United States / Q000453:epidemiology; D001741:Black or African American
chemical_list: C495139:MSR1 protein, human; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A