Aziridinyl anions from a chiral, nonracemic 2-isopropylidineaziridine: surprisingly diastereoselective alkylation reactions.
Lithiation and alkylation of a 2-isopropylidineaziridine bearing an (S)-alpha-methylbenzyl group on nitrogen proceeds with high levels of diastereocontrol (80-90% de).
Hayes
J F
JF
GlaxoSmithKline, Old Powder Mills, Tonbridge, Kent, UK TN11 9AN.
Prévost
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N
Prokes
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Shipman
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Slawin
A M Z
AM
Twin
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