Topical treatment of persistent cutaneous leishmaniasis with ethanolic lipid amphotericin B.
A 1.5-year-old infant was referred because of spreading skin lesions diagnosed earlier as cutaneous leishmaniasis that did not respond to repeated courses with paromomycin-containing ointment. After consideration of the alternative therapeutic options, the infant was treated with a topical colloidal solution of amphotericin B for 3 weeks, This mode of therapy resulted in resolution of the skin lesions. No local or systemic side effects were observed. There were no signs of recurrence 3 months after cessation of the treatment.
Zvulunov
Alex
A
Department of Pediatrics, Joseftal Hospital, PO Box 600, Eilat, 88000 Israel. Azvulun@bgumail.bgu.ac.il
Cagnano
Emanuala
E
Frankenburg
Shoshana
S
Barenholz
Yehezkel
Y
Vardy
Daniel
D
D000287:Administration, Topical; D000666:Amphotericin B / Q000008:administration & dosage*; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis* / Q000188:drug therapy*; D012008:Recurrence; D012720:Severity of Illness Index; D012996:Solutions; D016896:Treatment Outcome
D012996:Solutions; D000666:Amphotericin B