title: SWISS-MODEL: An automated protein homology-modeling server.
abstract: SWISS-MODEL (http://swissmodel.expasy.org) is a server for automated comparative modeling of three-dimensional (3D) protein structures. It pioneered the field of automated modeling starting in 1993 and is the most widely-used free web-based automated modeling facility today. In 2002 the server computed 120 000 user requests for 3D protein models. SWISS-MODEL provides several levels of user interaction through its World Wide Web interface: in the 'first approach mode' only an amino acid sequence of a protein is submitted to build a 3D model. Template selection, alignment and model building are done completely automated by the server. In the 'alignment mode', the modeling process is based on a user-defined target-template alignment. Complex modeling tasks can be handled with the 'project mode' using DeepView (Swiss-PdbViewer), an integrated sequence-to-structure workbench. All models are sent back via email with a detailed modeling report. WhatCheck analyses and ANOLEA evaluations are provided optionally. The reliability of SWISS-MODEL is continuously evaluated in the EVA-CM project. The SWISS-MODEL server is under constant development to improve the successful implementation of expert knowledge into an easy-to-use server.
authors.affiliation: Biozentrum der Universität Basel, Klingelbergstr. 50-70, CH 4056 Basel, Switzerland. torsten.schwede@unibas.ch
authors.forename: Torsten
authors.initials: T
authors.lastname: Schwede
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kopp
authors.forename: Nicolas
authors.initials: N
authors.lastname: Guex
authors.forename: Manuel C
authors.initials: MC
authors.lastname: Peitsch
mesh_terms: D003196:Computer Graphics; D020407:Internet; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D012984:Software; D040681:Structural Homology, Protein; D014584:User-Computer Interface
chemical_list: D011506:Proteins