[Nasal NK/T lymphoma. A case report].
We report a case of nasal NK/T lymphoma occurring in a 42 year old man, after a 2 year history of nasal obstruction initially related to chronic sinusitis. A first superficial biopsy was not contributive. Twenty months later, a second nasal biopsy led to the diagnosis of nasal NK/T cell lymphoma in view of the presence of a pleomorphic lymphoid infiltrate associated with necrosis and angiocentric features. Extensive immunohistochemical studies performed on paraffin and frozen sections together with genotypic analysis supported the NK cell origin of the neoplastic cells. In addition, EBV infection was established by in situ hybridization which showed EBERs transcripts in the nuclei of virtually all neoplastic cells. The tumour rapidly progressed and the patient died six months after diagnosis.
Ladeb
Saloua
S
Centre National de Greffe de Moelle Osseuse, rue Jebel Lakhdar, 1006 Bab Saadoun, Tunis, Tunisie.
Gaulard
Philippe
P
Ben Othmen
Tarek
T
Abd Alsamad
Issam
I
Delfau-Larue
Marie Hélène
MH
Abdelkefi
Abderrahmen
A
Torjmen
Lamia
L
Ben Abdeladhim
Abdeladhim
A
D000328:Adult; D001706:Biopsy; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000382:microbiology / Q000473:pathology*; D008297:Male; D015508:Nasal Obstruction / Q000209:etiology; D009669:Nose Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*