[Lipoprotein (a) and cerebral infarction in young adults].
OBJECTIVE
To investigate the relation between lipoprotein (a) (LP(a)) and cerebral infarction in young adults.


METHODS
Serum LP(a) of 90 young adults (age below 45 years) with cerebral infarction was measured. Serum lipids include triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A-I (ApoA-I) and apolipoprotein B (ApoB) were also measured. Other possible risk factors such as hypertension, smoking, drinking and family stroke history were reviewed.


RESULTS
There was no significant difference of serum LP(a) value between stroke patients and controls. TG (P < 0.01) and ApoB (P < 0.01) values in patients with cerebral infarction were significant higher than those in controls. Lipoprotein (a) was correlated with total cholesterol and low density lipoprotein cholesterol, with the values of correlation coefficient (r) 0.28 and 0.23 (both P < 0.01). After adjustment for age, sex, hypertension, smoking, drinking alcohol, family stroke history and other serum lipids, the odd radio for LP(a) and cerebral infarction was 0.74 (95% CI: 0.27 - 1.98). The odd radio for elevated TG was 3.57 (95% CI: 1.34 - 9.49); The odd ratios for hypertension, heart diseases and smoking as risk factors for cerebral infarction in young patients showed as: hypertension OR = 8.18, 95% CI: 2.54 - 26.33; heart diseases: OR = 8.51, 95% CI: 2.27 - 31.85; smoking: OR = 3.21, 95% CI: 1.27 - 8.13.


CONCLUSIONS
LP(a) might not be a risk factor for cerebral infarction in young patients while elevated triglyceride, hypertension, heart diseases and smoking were important risk factors in young adults with cerebral infarction.
Cao
Gui-fang
GF
Department of Neurology, Xiangya Hospital, Central Southern University, Changsha 410008, China.
Yang
Qi-dong
QD
Liu
Yun-hai
YH
Li
Hai-yan
HY
Xu
Hong-wei
HW
Xia
Jian
J
D000328:Adult; D000367:Age Factors; D002544:Cerebral Infarction / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D017270:Lipoprotein(a) / Q000097:blood*; D016015:Logistic Models; D008297:Male; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood
D017270:Lipoprotein(a); D014280:Triglycerides