[Metabolic aspects of reperfusion syndrome in patients with chronic ischemia of the lower limbs after surgical revascularization].
24 patients with chronic lower limb ischemia were examined during arterial reconstructive surgery and on the first postoperative day. The parameters of acid-base balance, lipid peroxidation and antioxidant system were measured in arterial and venous blood to determine laboratory criteria of the reperfusion syndrome. The arteriovenous oxygen difference decreased after revascularization while chemiluminescence emission, malonic dialdehyde concentration, antioxidant activity coefficient and medium-weight molecules elevated. On the first postoperative day all these parameters recovered but remained higher than their baseline values. These data illustrate excessive production of free oxygen radicals after limb revascularization, which contributes to reperfusion syndrome. Since determination of lipid peroxidation and antioxidant activity is a time-consuming work, levels of medium-weight molecules content in plasma may indicate reperfusion damage to the limb.
Kukaeva
E A
EA
Andrianova
M Iu
MIu
Paliulina
M V
MV
Mil'chakov
V I
VI
D000136:Acid-Base Equilibrium; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007511:Ischemia / Q000378:metabolism* / Q000601:surgery*; D007866:Leg / Q000098:blood supply* / Q000601:surgery; D015227:Lipid Peroxidation; D008163:Luminescent Measurements; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D017382:Reactive Oxygen Species / Q000097:blood; D015427:Reperfusion Injury / Q000378:metabolism*; D014656:Vascular Surgical Procedures / Q000009:adverse effects / Q000379:methods*
D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D010100:Oxygen