title: The AAI index, the BIS index and end-tidal concentration during wash in and wash out of sevoflurane.
abstract: The bispectral index (BIS), auditory evoked potential index (AAI) and the end-tidal sevoflurane concentration were studied during induction and emergence in 10 ASA I-II patients. Both during 'wash-in' and 'wash-out' of sevoflurane, the AAI and BIS indices show huge variability and an overlap of indices between awake and not responding to command. This was the most pronounced during induction and the range of values was larger for the AAI index as compared with the BIS index. Mean (range) BIS was 85 (73-98) and 48 (10-83) awake and unconscious, respectively, and mean AAI index was 71 (43-99) and 21 (4-85), respectively. This study demonstrates the difficulties of using processed EEG variables in real time in a clinical situation of non-steady state pharmacodynamics.
authors.affiliation: Department of Cardiothoracic Anaesthetics and Intensive Care, Sabbatsberg Hospital, S-113 24 Stockholm, Sweden.
authors.forename: R E
authors.initials: RE
authors.lastname: Anderson
authors.forename: G
authors.initials: G
authors.lastname: Barr
authors.forename: H
authors.initials: H
authors.lastname: Assareh
authors.forename: J
authors.initials: J
authors.lastname: Jakobsson
mesh_terms: D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics / Q000494:pharmacology*; D001364:Awareness / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D006801:Humans; D008738:Methyl Ethers / Q000493:pharmacokinetics / Q000494:pharmacology*; D016343:Monitoring, Intraoperative / Q000379:methods*; D015203:Reproducibility of Results; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane