Association of polymorphisms of interleukin-6, osteocalcin, and vitamin D receptor genes, alone or in combination, with bone mineral density in community-dwelling Japanese women and men.
We examined whether the -634C-->G, 298C-->T, and 2C-->T polymorphisms of the IL-6, osteocalcin, and vitamin D receptor (VDR) genes, respectively, were associated, alone or in combination, with bone mineral density (BMD) in community-dwelling Japanese women (between 1108 and 1113) or men (between 1116 and 1130) aged 40-79 yr. The -634C-->G polymorphism of the IL-6 gene and the 298C-->T polymorphism of the osteocalcin gene were associated with BMD in postmenopausal women, with the respective GG and TT genotypes representing risk factors for reduced bone mass. IL-6 and osteocalcin genotypes showed additive effects on BMD for postmenopausal women. The 2C-->T polymorphism of the VDR gene was associated with BMD in men, with the CT genotype contributing to reduced BMD. These results suggest that the IL-6 and osteocalcin genes are susceptibility loci for reduced BMD in postmenopausal women and that the VDR gene constitutes such a locus in men. The combined IL-6 and osteocalcin genotypes may prove informative for the assessment of osteoporosis in women.
Yamada
Yoshiji
Y
Department of Gene Therapy, Gifu International Institute of Biotechnology and Institute of Applied Biochemistry, Mitake, Gifu 505-0116, Japan. yoyomada@giib.or.jp
Ando
Fujiko
F
Niino
Naoakira
N
Shimokata
Hiroshi
H
D000328:Adult; D000368:Aged; D015519:Bone Density / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D007564:Japan; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000235:genetics*; D010024:Osteoporosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D018167:Receptors, Calcitriol / Q000235:genetics*
D015850:Interleukin-6; D018167:Receptors, Calcitriol; D015675:Osteocalcin