title: Local anesthetic switching for intrathecal tachyphylaxis in cancer patients with pain.
abstract: Switching from bupivacaine to lidocaine may improve intrathecal morphine analgesia in advanced cancer patients, possibly because of different spinal mechanisms limiting the hyperalgesic processes.
authors.affiliation: Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Mercadante
authors.forename: P
authors.initials: P
authors.lastname: Villari
authors.forename: P
authors.initials: P
authors.lastname: Ferrera
authors.forename: E
authors.initials: E
authors.lastname: Arcuri
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000009:adverse effects* / Q000627:therapeutic use*; D002045:Bupivacaine / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000150:complications; D016889:Endometrial Neoplasms / Q000150:complications; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000150:complications; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D010148:Intractable Pain / Q000188:drug therapy* / Q000209:etiology*; D010166:Palliative Care; D013274:Stomach Neoplasms / Q000150:complications; D013618:Tachyphylaxis / Q000502:physiology*; D002583:Uterine Cervical Neoplasms / Q000150:complications
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine; D002045:Bupivacaine