title: Comparison of the haemodynamic effects of right ventricular outflow-tract pacing with right ventricular apex pacing: a quantitative review.
abstract: The right ventricular apex has been used for cardiac stimulation because this position is easily accessible and is associated with a stable position of the electrode with a low dislodgement rate. This position, however, is associated with a dyssynchronous left ventricular contraction with subsequent deleterious haemodynamic effects. Alternative stimulation sites have been studied extensively because of a potentially better haemodynamic effect compared with right ventricular apex pacing. Using a Cochrane search strategy, nine studies were selected to analyze the haemodynamic effects of right ventricular outflow-tract pacing. The results of these studies (n=217) were pooled and indicated a significantly better haemodynamic effect (odds ratio 0.34, confidence interval 0.15-0.53) compared with right ventricular apex pacing. Therefore, these data suggest that right ventricular outflow-tract pacing may offer a modest but significant benefit over right ventricular apex pacing in patients selected for pacemaker implantation on the basis of symptomatic bradyarrhythmias.
authors.affiliation: Department of Cardiology, VU Medical Center, Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. c.c.dcock@azvu.nl
authors.forename: C C
authors.initials: CC
authors.lastname: de Cock
authors.forename: M C
authors.initials: MC
authors.lastname: Giudici
authors.forename: J W
authors.initials: JW
authors.lastname: Twisk
mesh_terms: D001919:Bradycardia / Q000503:physiopathology / Q000628:therapy*; D002304:Cardiac Pacing, Artificial / Q000009:adverse effects*; D006352:Heart Ventricles / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D018487:Ventricular Dysfunction, Left / Q000209:etiology* / Q000503:physiopathology*