title: Spread and survival of promiscuous IncP-1 plasmids.
abstract: Plasmids classified to the IncP-1 incompatibility group belong to the most stably maintained mobile elements among low copy number plasmids known to date. The remarkable persistence is achieved by various tightly controlled stability mechanisms like active partitioning, efficient conjugative transfer system, killing of plasmid-free segregants and multimer resolution. The unique feature of IncP-1 plasmids is the central control operon coding for global regulators which control the expression of genes involved in vegetative replication, stable maintenance and conjugative transfer. The multivalent regulatory network provides means for coordinated expression of all plasmid functions. The current state of knowledge about two fully sequenced plasmids RK2 and R751, representatives of the IncP-1alpha and IncP-1beta subgroups, is presented.
authors.affiliation: Department of Microbial Biochemistry, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, A. Pawińskiego 5a, 02-106 Warsaw, Poland. malada@ibb.waw.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Adamczyk
authors.forename: Grazyna
authors.initials: G
authors.lastname: Jagura-Burdzy
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D003227:Conjugation, Genetic; D004261:DNA Replication; D018628:Gene Dosage; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D005809:Genes, Regulator; D009875:Operator Regions, Genetic; D009876:Operon; D010957:Plasmids; D011487:Protein Conformation; D012097:Repressor Proteins / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D012097:Repressor Proteins