title: Connecting sequence and biology in the laboratory mouse.
abstract: The Mouse Genome Sequencing Consortium and the RIKEN Genome Exploration Research grouphave generated large sets of sequence data representing the mouse genome and transcriptome, respectively. These data provide a valuable foundation for genomic research. The challenges for the informatics community are how to integrate these data with the ever-expanding knowledge about the roles of genes and gene products in biological processes, and how to provide useful views to the scientific community. Public resources, such as the National Center for Biotechnology Information (NCBI; http://www.ncbi.nih.gov), and model organism databases, such as the Mouse Genome Informatics database (MGI; http://www.informatics.jax.org), maintain the primary data and provide connections between sequence and biology. In this paper, we describe how the partnership of MGI and NCBI LocusLink contributes to the integration of sequence and biology, especially in the context of the large-scale genome and transcriptome data now available for the laboratory mouse. In particular, we describe the methods and results of integration of 60,770 FANTOM2 mouse cDNAs with gene records in the databases of MGI and LocusLink.
authors.affiliation: Mouse Genome Informatics Group, The Jackson Laboratory, Bar Harbor, Maine 04609, USA. rmb@informatics.jax.org
authors.forename: Richard M
authors.initials: RM
authors.lastname: Baldarelli
authors.forename: David P
authors.initials: DP
authors.lastname: Hill
authors.forename: Judith A
authors.initials: JA
authors.lastname: Blake
authors.forename: Jun
authors.initials: J
authors.lastname: Adachi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Furuno
authors.forename: Dirck
authors.initials: D
authors.lastname: Bradt
authors.forename: Lori E
authors.initials: LE
authors.lastname: Corbani
authors.forename: Sharon
authors.initials: S
authors.lastname: Cousins
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Frazer
authors.forename: Dong
authors.initials: D
authors.lastname: Qi
authors.forename: Longlong
authors.initials: L
authors.lastname: Yang
authors.forename: Sridhar
authors.initials: S
authors.lastname: Ramachandran
authors.forename: Deborah
authors.initials: D
authors.lastname: Reed
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Zhu
authors.forename: Takeya
authors.initials: T
authors.lastname: Kasukawa
authors.forename: Martin
authors.initials: M
authors.lastname: Ringwald
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: King
authors.forename: Lois J
authors.initials: LJ
authors.lastname: Maltais
authors.forename: Louise M
authors.initials: LM
authors.lastname: McKenzie
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Schriml
authors.forename: Donna
authors.initials: D
authors.lastname: Maglott
authors.forename: Deanna M
authors.initials: DM
authors.lastname: Church
authors.forename: Kim
authors.initials: K
authors.lastname: Pruitt
authors.forename: Janan T
authors.initials: JT
authors.lastname: Eppig
authors.forename: Joel E
authors.initials: JE
authors.lastname: Richardson
authors.forename: Jim A
authors.initials: JA
authors.lastname: Kadin
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Bult
mesh_terms: D000818:Animals; D001483:Base Sequence / Q000235:genetics* / Q000502:physiology; D019295:Computational Biology / Q000379:methods* / Q000706:statistics & numerical data; D003196:Computer Graphics / Q000706:statistics & numerical data / Q000639:trends; D018076:DNA, Complementary / Q000235:genetics / Q000502:physiology; D030541:Databases, Genetic / Q000706:statistics & numerical data / Q000639:trends; D005796:Genes / Q000235:genetics / Q000502:physiology; D016678:Genome; D020407:Internet / Q000706:statistics & numerical data / Q000639:trends; D051379:Mice
chemical_list: D018076:DNA, Complementary