title: Checking cell size in budding yeast: a systems biology approach.
abstract: The regulation of cell cycle progression via the attainment of a critical cell size is a conserved feature from simpler unicellular organisms to mammalian cells that is obtaining much attention recently. Genome wide analysis of Saccharomyces cerevisiae deletion strains, genetic epistasis, DNA microarray analysis have recently revealed an increasingly complex network of cell size modulation mechanisms. A systems biology-based approach, that is needed to structure the underlying complexity of cell cycle regulatory mechanisms, is described.
authors.affiliation: Dipartimento di Biotecnologie e Bioscienze, Università di Milano-Bicocca, Milano-Italy. lilia.alberghina@unimib.it
authors.forename: Lilia
authors.initials: L
authors.lastname: Alberghina
authors.forename: Riccardo L
authors.initials: RL
authors.lastname: Rossi
authors.forename: Valeria
authors.initials: V
authors.lastname: Wanke
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Querin
authors.forename: Marco
authors.initials: M
authors.lastname: Vanoni
mesh_terms: D002453:Cell Cycle; D017353:Gene Deletion; D008954:Models, Biological; D020411:Oligonucleotide Array Sequence Analysis; D004718:Saccharomycetales / Q000235:genetics / Q000378:metabolism / Q000502:physiology*