title: Mild method for the conversion of amides to thioamides.
abstract: Aqueous ammonium sulfide was found to be an ideal substitute for hydrogen sulfide for the thiolysis of activated amides. High yields of the corresponding thioamides were obtained for a broad range of substrates, using two different procedures that are both operationally simple and inexpensive, as well as amenable to large-scale preparation. Preliminary results indicate that aqueous ammonium sulfide may also replace hydrogen sulfide in the synthesis of thionoesters from amides.
authors.affiliation: Département de Chimie, Université de Montréal, P.O. Box 6128, Station Downtown, Montréal, Québec, Canada H3C 3J7. andre.charette@umontreal.ca
authors.forename: André B
authors.initials: AB
authors.lastname: Charette
authors.forename: Michel
authors.initials: M
authors.lastname: Grenon