Bone marrow-derived stem cells initiate pancreatic regeneration.
We show that transplantation of adult bone marrow-derived cells expressing c-kit reduces hyperglycemia in mice with streptozotocin-induced pancreatic damage. Although quantitative analysis of the pancreas revealed a low frequency of donor insulin-positive cells, these cells were not present at the onset of blood glucose reduction. Instead, the majority of transplanted cells were localized to ductal and islet structures, and their presence was accompanied by a proliferation of recipient pancreatic cells that resulted in insulin production. The capacity of transplanted bone marrow-derived stem cells to initiate endogenous pancreatic tissue regeneration represents a previously unrecognized means by which these cells can contribute to the restoration of organ function.
Hess
David
D
Robarts Research Institute, Stem Cell Biology and Regenerative Medicine, 100 Perth Drive, London, Ontario N6A 5K8, Canada.
Li
Li
L
Martin
Matthew
M
Sakano
Seiji
S
Hill
David
D
Strutt
Brenda
B
Thyssen
Sandra
S
Gray
Douglas A
DA
Bhatia
Mickie
M
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D016026:Bone Marrow Transplantation / Q000379:methods*; D002455:Cell Division; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006943:Hyperglycemia / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D007328:Insulin / Q000378:metabolism; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D010182:Pancreatic Diseases / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D012038:Regeneration; D013311:Streptozocin; D016896:Treatment Outcome
D001786:Blood Glucose; D007328:Insulin; D013311:Streptozocin