title: Dynamic MRI and fine needle aspiration cytology in the evaluation of soft tissue lesions.
abstract: OBJECTIVE
  To assess the usefulness of dynamic magnetic resonance imaging (DMRI) in the diagnosis of soft tissue tumors.
  
  
  METHODS
  A DMRI series of 33 patients with soft tissue lesions was evaluated with regard to start, pattern, and progression of enhancement. Early enhancement, predominantly peripheral, and a time-signal intensity (TSI) curve characterized by a steep rise to an early peak followed by a plateau or washout, were considered signs of malignancy. The results were compared with the initial fine needle aspiration cytology (FNAC) diagnosis and the final diagnosis.
  
  
  RESULTS
  Twenty of 23 malignant lesions and three of 10 benign lesions exhibited at least two of the three enhancement characteristics attributed to malignancy. Using two or more DMRI features of malignancy to dichotomize the series, the sensitivity and positive predictive value of the DMRI series were 87% and, the specificity and negative predictive value were 70%. FNAC was conclusive except in two cases.
  
  
  CONCLUSIONS
  In tumor centers that rely on FNAC for preoperative diagnosis DMRI can be reserved for cytologically inconclusive cases. In centers that rely on open biopsy, DMRI may be useful as a coarse discriminator between benign and malignant lesions. However, larger series of soft tissue tumors need to be evaluated to conclusively identify the clinical role of DMRI.
authors.affiliation: Department of Radiology, Karolinska Hospital, Stockholm, Sweden. hildur.einarsdottir@ks.se
authors.forename: Hildur
authors.initials: H
authors.lastname: Einarsdóttir
authors.forename: Veli
authors.initials: V
authors.lastname: Söderlund
authors.forename: Lambert
authors.initials: L
authors.lastname: Skoog
authors.forename: Henrik C F
authors.initials: HC
authors.lastname: Bauer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D005121:Extremities / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008067:Lipoma / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000473:pathology; D009367:Neoplasm Staging; D011856:Radiographic Image Enhancement; D012189:Retrospective Studies; D012509:Sarcoma / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology*