title: Clinically significant gastrointestinal bleeding in critically ill patients with and without stress-ulcer prophylaxis.
abstract: OBJECTIVE
  To compare the rates of clinically significant gastrointestinal bleeding and the number of blood units and endoscopies required for gastrointestinal hemorrhage between patients receiving or not receiving stress-ulcer prophylaxis.
  
  
  METHODS
  Historical observational study comparing two consecutive periods: with (phase 1) and without stress-ulcer prophylaxis (phase 2).
  
  
  METHODS
  A 17-bed intensive care unit in a university teaching hospital. PATIENTS. In phase 1 there were 736 patients and in phase 2737. Those in the two phases were comparable in age and reason for admission; clinically significant gastrointestinal bleeding rates did not differ between the two phases, but patients in phase 2 were more severely ill.
  
  
  RESULTS
  Comparable numbers of blood units were transfused per bleeding patient in the two phases, especially for patients with significant gastrointestinal bleeding. During each phase 19 fibroscopies were performed for significant bleeding, and two patients required surgery. The clinically significant gastrointestinal bleeding rate and outcome did not differ in patients with at least one risk factor. Total expenditures directly related to gastrointestinal bleeding were similar during the two phases; the total cost incurred by stress-ulcer prophylaxis was estimated at <euro>6700.
  
  
  CONCLUSIONS
  Our results suggest that stress-ulcer prophylaxis does not influence the clinically significant gastrointestinal bleeding rate in intensive care unit patients or the cost of its management.
authors.affiliation: Service de Réanimation Médicale, Hôpital Européen Georges-Pompidou, 20 rue Leblanc, 75908, Paris Cedex 15, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Faisy
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Guerot
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Diehl
authors.forename: Eléonore
authors.initials: E
authors.lastname: Iftimovici
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Fagon
mesh_terms: D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001803:Blood Transfusion; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000150:complications; D011899:Ranitidine / Q000627:therapeutic use*; D012189:Retrospective Studies; D012307:Risk Factors; D013312:Stress, Physiological / Q000150:complications*; D013392:Sucralfate / Q000627:therapeutic use*; D016896:Treatment Outcome; D014456:Ulcer / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000897:Anti-Ulcer Agents; D013392:Sucralfate; D011899:Ranitidine