High risk levels of lipoprotein(a) in Pakistani patients with type 2 diabetes mellitus.
OBJECTIVE
To find the prevalence of high risk levels of lipoprotein(a) [Lp(a)] and the ratio between low-density lipoprotein (LDL) and high-density lipoprotein (HDL) in patients with type 2 diabetes mellitus (DM) as evidence has been provided that Lp(a) and LDL can act additively in the development of atherogenesis.


METHODS
This cross sectional study was carried out at the Department of Chemical Pathology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from February 2001 to May 2001. The patients participating in the study were diagnosed cases of type 2 DM. Fasting blood samples were analyzed for Lp(a), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), glucose and glycosylated hemoglobin. The data was analyzed by computer software SPSS 10.


RESULTS
The data was analyzed by considering Lp(a) levels <30 mg/dl as desirable level and > or =30 mg/dl as the high risk level. It was found that in the control group 73.3% of individuals had desirable levels of Lp(a) while 26.7% had high risk levels. In diabetic patients with good glycemic control 56.6% of patients had desirable levels of Lp(a) while 43.4% had high risk levels. The same data was also analyzed by taking Lp(a) levels of <20 mg/dl as desirable levels and the same pattern was observed.


CONCLUSIONS
Diabetic patients have elevated levels of serum Lp(a) as compared to healthy subjects and the frequency of high risk levels of Lp(a) is also higher in diabetics compared to non-diabetic subjects. The increased prevalence of high risk levels in patients with type 2 DM may be due to increased prevalence of low molecular weight isoforms of apoprotein(a) [apo(a)].
Habib
Syed S
SS
Department of Physiology, College of Medicine, King Saud University, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia. shahidhabib44@hotmail.com
Aslam
Muhammad
M
D000328:Adult; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology*; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D012307:Risk Factors
D017270:Lipoprotein(a)