Persistent anticonvulsant hypersensitivity syndrome responding to ciclosporin.
The drug hypersensitivity syndrome is a severe, multisystem reaction that typically develops within 2 months of starting a drug. We describe a case which has been unusually persistent, requiring prolonged treatment with systemic corticosteroids and after 1 year, ciclosporin. To the best of our knowledge, the use of ciclosporin for the treatment of the drug hypersensitivity syndrome has not been described previously.
Harman
K E
KE
Department of Dermatology, King's College Hospital, Denmark Hill, London, UK. karen.harman@uhl-tr.nhs.uk
Morris
S D
SD
Higgins
E M
EM
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D001706:Biopsy; D016572:Cyclosporine / Q000008:administration & dosage*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D003875:Drug Eruptions / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015848:Interleukin-5 / Q000378:metabolism; D000077213:Lamotrigine; D010672:Phenytoin / Q000009:adverse effects*; D011537:Pruritus / Q000139:chemically induced; D014227:Triazines / Q000009:adverse effects*
D000927:Anticonvulsants; D003879:Dermatologic Agents; D015848:Interleukin-5; D014227:Triazines; D010672:Phenytoin; D016572:Cyclosporine; D000077213:Lamotrigine