Synthesis and biological properties of DNA-peptide conjugates.
Some naturally occurring nuclear localizing signals (NLSs) and some artificially designed peptides were covalently conjugated by solid phase fragment condensation (SPFC) method. These DNA-peptide conjugates showed enhanced permeability into cells as well as enhanced hybrid stability with ssDNA and dsDNA, and also higher resistance against nuclease digestion.
Kubo
T
T
Department of Environmental and Biological Chemistry, Kyushu School of Engineering, Kinki University.
Yokoyama
K
K
Sasaki
K
K
Dubey
K K
KK
Fujii
M
M
D001483:Base Sequence; D002463:Cell Membrane Permeability; D004247:DNA / Q000737:chemistry; D003850:Deoxyribonuclease I / Q000378:metabolism; D019913:Nuclear Localization Signals; D009693:Nucleic Acid Hybridization; D020319:Oligodeoxyribonucleotides, Antisense / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry*
D019913:Nuclear Localization Signals; D020319:Oligodeoxyribonucleotides, Antisense; D010455:Peptides; D004247:DNA; D003850:Deoxyribonuclease I