Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa.
The activities of carbapenems against Pseudomonas aeruginosa decreased in the presence of siliconized latex urinary catheters (SLUCs). This effect was associated with the loss of OprD. The zinc that eluted from SLUCs is responsible for this phenomenon. We have found that zinc exerts a negative effect on the expression of OprD, the porin responsible for carbapenem entry into P. aeruginosa.
Conejo
M Carmen
MC
Department of Microbiology, School of Medicine, University of Seville, Seville, Spain. cconejo@us.es
García
Isabel
I
Martínez-Martínez
Luis
L
Picabea
Leandro
L
Pascual
Alvaro
A
D015780:Carbapenems / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D007840:Latex; D008826:Microbial Sensitivity Tests; D018272:Porins / Q000096:biosynthesis*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D012825:Silicon; D014546:Urinary Catheterization / Q000009:adverse effects*; D015032:Zinc / Q000494:pharmacology*
D015780:Carbapenems; D007840:Latex; D018272:Porins; C077157:OprD protein, Pseudomonas aeruginosa; D015032:Zinc; D012825:Silicon