[Treatment of second primary malignant tumor induced by radiotherapy].
OBJECTIVE
To study the diagnosis and treatment of a second primary malignant tumor induced by previous radiotherapy.


METHODS
From March 1970 to March 1997, 108 nasopharyngeal cancer (NPC) patients who developed a second primary malignant tumor induced by radiotherapy were treated. There were squamous carcinoma 43 (39.8%), sarcoma 26 (24.1%), malignant fibrous histiocytoma 14 (13.0%), adenoid cystic carcinoma 12 (11.1%), thyroid papillary adenocarcinoma 8 (7.4%) and malignant melanoma 5 (4.6%). Fifty patients underwent operation, 32 received radiotherapy, 18 received chemotherapy and 8 received operation combined with chemotherapy.


RESULTS
The 3- and 5-year tumor-free survival rates were 64.0% and 36.0% in the operation group. They were 34.4% and 18.8% in the radiotherapy group.


CONCLUSIONS
Surgery, if not contra-indicated, is the first choice for the second primary malignant tumor induced by radiotherapy. Aggressive treatment for these patients is, hence, indicated clinically.
Wu
Guo-hao
GH
Department of Head and Neck, Tumor Hospital, Sun Yat-sen University, Guangzhou 510060, China.
Chen
Fu-jin
FJ
Zeng
Zong-yuan
ZY
Li
Hao
H
Lin
Guo-wu
GW
Song
Ming
M
Wei
Mao-wen
MW
Xu
Guang-pu
GP
Yang
An-kui
AK
Chen
Wen-kuan
WK
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects*; D015996:Survival Rate