title: An improved procedure for the preparation of 8-substituted guanines.
abstract: The preparation of 8-substituted guanines using a new phosphorus(III)-mediated cyclisation of 4-acylamino-5-nitrosopyrimidines as the key step is described.
authors.affiliation: Laboratorium für Organische Chemie, ETH-Hönggerberg, CH-8093 Zürich, Switzerland.
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.forename: Fabio
authors.initials: F
authors.lastname: De Giacomo
authors.forename: Duncan E
authors.initials: DE
authors.lastname: Paterson
authors.forename: Tesmol G
authors.initials: TG
authors.lastname: George
authors.forename: Andrea
authors.initials: A
authors.lastname: Vasella
mesh_terms: D000215:Acylation; D003500:Cyclization; D006147:Guanine / Q000031:analogs & derivatives*; D008956:Models, Chemical; D009603:Nitroso Compounds / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry; D010084:Oxidation-Reduction; D010758:Phosphorus / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D009603:Nitroso Compounds; D009943:Organophosphorus Compounds; D011743:Pyrimidines; C061896:triphenylphosphine; D010758:Phosphorus; D006147:Guanine