title: [Two cases of vesical nephrogenic adenoma].
abstract: Case 1: A 52-year-old man receiving regular treatment for quadriplegia due to Friedreich disease visited our hospital with the chief complaint of macroscopic hematuria. He had undergone cystostomy 12 years ago due to neurogenic bladder. The computed tomography and cystoscopic examination revealed a bladder tumor with a few bladder stones. Transurethral resection of bladder tumor (TUR-Bt) was performed after bladder stone removal in May 2000. The pathological diagnosis showed nephrogenic adenoma. Case 2: A 54-year-old man had been treated with bladder tumor by TUR-Bt in Nov. 1995. The pathological diagnosis showed transitional cell carcinoma, G3, pT2 and intravesical instillation therapy using THP was performed. The bladder tumor had recurred twice and the instillation therapy had been exchanged to BCG since Nov. 1997. A small bladder tumor was observed in Jan. 2001, and from the biopsy specimen it was diagnosed as nephrogenic adenoma. Forty-six cases of urothelial nephrogenic adenoma including our cases have been reported in Japan. Chronic stimulation such as bladder stone and infection is thought to induce nephrogenic adenoma. BCG instillation therapy is believed to be an initiation factors for nephrogenic adenoma.
authors.affiliation: Department of Urology, Hirata Urological Clinic.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsurukawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Komura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sasaki
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Iuchi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tokumitsu
authors.forename: Yuji
authors.initials: Y
authors.lastname: Saga
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Sunao
authors.initials: S
authors.lastname: Yachiku
mesh_terms: D000236:Adenoma / Q000473:pathology* / Q000601:surgery; D002295:Carcinoma, Transitional Cell / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000601:surgery; D013520:Urologic Surgical Procedures / Q000379:methods