[Application of gene therapy mediated by adenovirus vectors for bone trauma and bone disease].
OBJECTIVE
To review the current concepts of gene therapy approaches mediated by adenovirus vectors for bone trauma and bone disease.


METHODS
The recent literature concerned gene therapy mediated by adenovirus vectors was reviewed, which provides new insights into the treatments of bone trauma and bone disease.


RESULTS
Adenovirus vectors was efficient, achieved high expression after transduction, and could transfer genes to both replicating and nonreplicating cells, such as osteoblasts, osteoclasts, fibroblasts, chondrocytes, bone marrow stromal cells, etc. Gene therapy mediated by adenovirus vectors achieved affirmative results in enhancing bone union and in curing bone diseases, such as osteoporosis and rheumatoid arthritis.


CONCLUSIONS
Gene therapy mediated by adenovirus offers an exciting avenue for treatment of bone trauma and bone diseases.
Liu
Ji-zhong
JZ
Institute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an Shaanxi, P.R. China 710032.
Ji
Zong-ling
ZL
Hu
Yun-yu
YY
D000256:Adenoviridae / Q000235:genetics*; D001847:Bone Diseases / Q000628:therapy*; D050723:Fractures, Bone / Q000628:therapy; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors