title: Antifungal compounds from Zanthoxylum chiloperone var. angustifolium.
abstract: An alkaloidal extract of the stem barks of Zanthoxylum chiloperone var. angustifolium exhibited antifungal activity against Candida albicans, Aspergillus fumigatus and Trichophyton mentagrophytes var. interdigitale using a TLC bioautographic method. Bioassay-guided fractionation of this extract resulted in the isolation of two active compounds identi fi ed as canthin-6-one and 5-methoxycanthin-6-one. Canthin-6-one exhibited a broad spectrum of activities against Aspergillus fumigatus, A. niger, A. terreus, Candida albicans, C. tropicalis, C. glabrata, Cryptococcus neoformans, Geotrichum candidum, Saccharomyces cerevisiae, Trichosporon beigelii, Trichosporon cutaneum and Trichophyton mentagrophytes var. interdigitale with MICs values between 5.3 and 46 micro mol/L. 5-methoxy-canthin-6-one was active against only Trichophyton mentagrophytes var. interdigitale with a MIC value of 12.3 micro mol/L.
authors.affiliation: Laboratoire de Pharmacognosie UPRES-A 8076 CNRS (BIOCIS), Faculté de Pharmacie, 92296 Châtenay-Malabry, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Thouvenel
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Gantier
authors.forename: Philippe
authors.initials: P
authors.lastname: Duret
authors.forename: Christophe
authors.initials: C
authors.lastname: Fourneau
authors.forename: Reynald
authors.initials: R
authors.lastname: Hocquemiller
authors.forename: Maria-Elena
authors.initials: ME
authors.lastname: Ferreira
authors.forename: Antonieta
authors.initials: A
authors.lastname: Rojas de Arias
authors.forename: Alain
authors.initials: A
authors.lastname: Fournet
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002243:Carbolines; D006801:Humans; D026121:Indole Alkaloids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007654:Ketoconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects*; D009287:Naphthyridines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D014249:Trichophyton / Q000187:drug effects; D032106:Zanthoxylum
chemical_list: D000935:Antifungal Agents; D002243:Carbolines; D026121:Indole Alkaloids; D007211:Indoles; D009287:Naphthyridines; D010936:Plant Extracts; C453379:canthin-6-one; D007654:Ketoconazole; C468517:5-methoxycanthin-6-one