title: New cytotoxic indolic metabolites from a marine Streptomyces.
abstract: Three new cytotoxic 3,6-disubstituted indoles (1-3) were isolated from the mycelium of a strain identified as Streptomyces sp. (BL-49-58-005), which was separated from a Mexican marine invertebrate, and their structures established by analysis of NMR and mass spectral data. GI(50) values for 1 and 2 in cytotoxic bioassays against a panel of 14 different tumor cell lines were estimated at micromolar range, while compound 3 showed no activity in the same assays.
authors.affiliation: Instituto Biomar, S. A., 24231 Onzonilla, León, Spain. p.naturales@institutobiomar.com
authors.forename: José M
authors.initials: JM
authors.lastname: Sánchez López
authors.forename: Marta
authors.initials: M
authors.lastname: Martínez Insua
authors.forename: Julia
authors.initials: J
authors.lastname: Pérez Baz
authors.forename: José L
authors.initials: JL
authors.lastname: Fernández Puentes
authors.forename: Librada M
authors.initials: LM
authors.lastname: Cañedo Hernández
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007938:Leukemia; D008297:Male; D008800:Mexico; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010190:Pancreatic Neoplasms; D011471:Prostatic Neoplasms; D013302:Streptomyces / Q000737:chemistry*
chemical_list: C478731:6-prenyltryptophol; D000970:Antineoplastic Agents; D007211:Indoles