title: Differences in the frequency of resistance to antiretroviral drug classes among human immunodeficiency virus type 1 clinical isolates.
abstract: Genotypic resistance to all antiretroviral classes was widespread among human immunodeficiency virus type 1 isolates failing therapy. Resistance to nonnucleoside reverse transcriptase inhibitors was found most frequently and resistance to protease inhibitors was found least frequently, most likely due to differences in the number of enzymatic amino acid substitutions leading to resistance to each particular drug class.
authors.affiliation: Division of Infectious Diseases, University of Miami School of Medicine, Miami, Florida, USA. rcampo@med.miami.edu
authors.forename: Rafael E
authors.initials: RE
authors.lastname: Campo
authors.forename: Paola N
authors.initials: PN
authors.lastname: Lichtenberger
authors.forename: Isabella
authors.initials: I
authors.lastname: Rosa
authors.forename: German
authors.initials: G
authors.lastname: Suarez
authors.forename: Fernando A
authors.initials: FA
authors.lastname: Rivera
authors.forename: Allan E
authors.initials: AE
authors.lastname: Rodriguez
authors.forename: Dushyantha T
authors.initials: DT
authors.lastname: Jayaweera
authors.forename: Natalie A
authors.initials: NA
authors.lastname: Wahlay
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kolber
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology; D016333:HIV Protease / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008297:Male; D015995:Prevalence; D011480:Protease Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D011480:Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase; D016333:HIV Protease