title: The effect of high dose of cortisol on glucose-6-phosphatase and fructose-1,6-bisphosphatase activity, and glucose and fructose-2,6-bisphosphate concentration in carp tissues (Cyprinus carpio L.).
abstract: The effect of a high dose of cortisol (200 mg kg(-1) body mass) on juvenile carp was investigated. The activity of glucose-6-phosphatase in liver and of fructose-1,6-bisphosphatase in liver, kidney and muscle, the serum glucose and fructose-2,6-bisphosphate concentration as well as the serum concentration of the injected hormone were measured after 24, 72 and 216 h after intraperitoneal cortisol injection. The activities of fructose-1,6-bisphosphatase in liver and kidney and glucose-6-phosphatase in liver were elevated in comparison with the control, while the fructose-1,6-bisphosphatase activity in the muscle tissue was unchanged. After cortisol injection, the serum glucose level was nearly two times higher after 24 and 72 h and was still 50% higher after 216 h compared with controls. In contrast, the liver fructose-2,6-bisphosphate concentration was unchanged after 24 h. More than two times higher fructose-2,6-bisphosphate concentration was observed in liver after 72 h and it was still elevated after 216 h after the cortisol injection.
authors.affiliation: Department of Animal Physiology, Zoological Institute, Wrocław University, Cybulskiego 30, 50-205, Wrocław, Poland.
authors.forename: Daria
authors.initials: D
authors.lastname: Dziewulska-Szwajkowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Łozińska-Gabska
authors.forename: Anna
authors.initials: A
authors.lastname: Adamowicz
authors.forename: Jan
authors.initials: J
authors.lastname: Wojtaszek
authors.forename: Andrzej
authors.initials: A
authors.lastname: Dzugaj
mesh_terms: D000249:Adenosine Monophosphate / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002347:Carps / Q000097:blood / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006597:Fructose-Bisphosphatase / Q000378:metabolism*; D005635:Fructosediphosphates / Q000378:metabolism*; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D006854:Hydrocortisone / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D009132:Muscles / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology
chemical_list: D001786:Blood Glucose; D005635:Fructosediphosphates; D000249:Adenosine Monophosphate; C027652:fructose 2,6-diphosphate; D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase; D006854:Hydrocortisone