One-pot hydrogenation conditions for a sequential process to (+)-monomorine.
(+)-Monomorine has been synthesized under mild hydrogenation conditions initiating deprotection followed by intramolecular, sequential reductive amination reactions. The precursors could be prepared concisely using B-alkyl Suzuki cross coupling of a chiral homoallylamine and a vinyl iodide or an iodofuran derivative.
Kim
Guncheol
G
Department of Chemistry, College of Natural Science, Chungnam National University, Taejon 305-764, Korea. guncheol@cnu.ac.kr
Jung
Sung-Do
SD
Lee
Eun-Ju
EJ
Kim
Nakjeong
N
D000470:Alkaloids / Q000138:chemical synthesis*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006865:Hydrogenation; D007212:Indolizines / Q000138:chemical synthesis*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
D000470:Alkaloids; D007212:Indolizines; C110223:indolizidine-195B