Copper reagents: a new and efficient solution for the selective addition of metallated propargylic amines to aldehydes.
[reaction: see text] Anti alpha-amino-homopropargylic alcohols are prepared by addition of metallated propargylic amines to aldehydes. Among the four organometallic (LI, Zn, Ti, Cu) derivatives used, the most effective are the copper reagents.
Bernaud
Frederic
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UMR 7611-Laboratoire de Chimie Organique, Université Pierre et Marie Curie, 4 Place Jussieu, F-75252, Paris, Cedex 05, France.
Vrancken
Emmanuel
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Mangeney
Pierre
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