Understanding the effects of the polymer support on reaction rates and kinetics: knowledge toward efficient synthetic design.
Solid-phase organic synthesis (SPOS) has an ever-expanding role in the field of organic synthesis. Partially out of difficulty, and partially from the rapid speed of progress, few basic studies on the role of the physical structure of the resin have been undertaken, and the dissemination of the existing knowledge has been slow. Major advances have been made in the understanding of the many factors that govern a SPOS reaction's performance as a function of the choice of solid support.
Walsh
Daniel
D
Department of Chemistry, New York University, 29 Washington Place, Brown Building, Room 564, New York, NY 10003, USA.
Wu
Daqian
D
Chang
Young-Tae
YT
D000577:Amides / Q000737:chemistry; D015195:Drug Design; D005456:Fluorescent Dyes; D007700:Kinetics; D011108:Polymers / Q000737:chemistry*
D000577:Amides; D005456:Fluorescent Dyes; D011108:Polymers