An antitumor agent of beta-cyclodextrin-modified titanocene complex: synthesis and characterization.
The complex of a derivative of beta-cyclodextrin, that is mono[6-deoxy-6-(2-butenedinitrile-2,3-dimercapto sodium salt)]-beta-cyclodextrin (6-mnt-beta-CD), with titanocene (titanocene di[mono[6-deoxy-6-(2-butenedinitrile-2,3-dimercapto)]-beta-cyclodextrin], Cp2Ti[6-mnt-beta-CD]2) has been synthesized and characterized by IR spectroscopy, UV spectroscopy, elemental analysis, thermogravimetry, 1H- and 13C-NMR spectroscopy. The stoichiometry of the target molecule was determined by 1H-NMR spectroscopy and elemental analysis.
Lu
Chang-Sheng
CS
Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University, PR China.
Zou
Yang
Y
Xie
Jing-Li
JL
Ni
Zhao-Ping
ZP
Zhu
Hui-Zheng
HZ
Meng
Qing-Jin
QJ
Yao
Yuan-Gen
YG
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D003505:Cyclodextrins / Q000138:chemical synthesis*; D006131:Growth Inhibitors / Q000138:chemical synthesis*; D009942:Organometallic Compounds / Q000138:chemical synthesis*; D047392:beta-Cyclodextrins
D000970:Antineoplastic Agents; D003505:Cyclodextrins; D006131:Growth Inhibitors; D009942:Organometallic Compounds; D047392:beta-Cyclodextrins; C406884:titanocene; C031215:betadex