title: Lipid metabolism in hypercholesterolemic rats affected by feeding cholesterol-free diets containing different amounts of non-dialyzed soybean protein fraction.
abstract: OBJECTIVE
  We investigated lipid metabolism in hypercholesterolemic rats after replacing casein with different amounts of undialyzed soybean protein fraction.
  
  
  METHODS
  The hypercholesterolemic rats were fed cholesterol-free diets containing 2%, 5%, or 10% undialyzed soybean protein fraction (UDSP) for 4 wk.
  
  
  RESULTS
  The 5% and 10% UDSP groups had significantly lower plasma cholesterol, triacylglycerol, and low-density lipoprotein cholesterol concentrations than did the other groups (P < 0.05). In addition, significantly higher fecal total steroid excretion was observed in these two groups. However, the different amounts of UDSP did not influence liver lipid, plasma high-density lipoprotein cholesterol, body weight gain, daily food intake, or feeding efficiency.
  
  
  CONCLUSIONS
  These results suggested a dose-dependent reduction in plasma cholesterol when casein was replaced stepwise with UDSP (5% or 10%) as a protein source. The hypocholesterolemic effect might have been due to an increase in total fecal steroid excretion.
authors.affiliation: Department of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan.
authors.forename: Jiun Rong
authors.initials: JR
authors.lastname: Chen
authors.forename: Shiau Fang
authors.initials: SF
authors.lastname: Chiou
authors.forename: Kunio
authors.initials: K
authors.lastname: Suetsuna
authors.forename: Hsin Yi
authors.initials: HY
authors.lastname: Yang
authors.forename: Suh Ching
authors.initials: SC
authors.lastname: Yang
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000737:chemistry; D006937:Hypercholesterolemia / Q000178:diet therapy / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D030262:Soybean Proteins / Q000008:administration & dosage*; D013261:Sterols / Q000032:analysis; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D008055:Lipids; D030262:Soybean Proteins; D013261:Sterols; D014280:Triglycerides; D002784:Cholesterol