title: Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.
abstract: Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. Alpha- and beta-mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 microg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.
authors.affiliation: Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand. sunit@swu.ac.th
authors.forename: Sunit
authors.initials: S
authors.lastname: Suksamrarn
authors.forename: Narisara
authors.initials: N
authors.lastname: Suwannapoch
authors.forename: Wong
authors.initials: W
authors.lastname: Phakhodee
authors.forename: Janthana
authors.initials: J
authors.lastname: Thanuhiranlert
authors.forename: Piniti
authors.initials: P
authors.lastname: Ratananukul
authors.forename: Nitirat
authors.initials: N
authors.lastname: Chimnoi
authors.forename: Apichart
authors.initials: A
authors.lastname: Suksamrarn
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005638:Fruit; D029762:Garcinia mangostana; D008826:Microbial Sensitivity Tests; D017368:Protein Prenylation; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D044004:Xanthones