Necrotizing glomerulonephritis in a living donor kidney transplant recipient.
The occurrence of a rapidly progressive necrotizing glomerulonephritis after kidney transplantation is exceptional and usually leads to graft failure. We describe a case of necrotizing glomerulonephritis that developed 5 months after renal transplantation in a patient suffering from prolonged bowel paralysis and sepsis. After reinforcement of corticosteroid therapy and introduction of cyclophosphamide, glomerulonephritis recovered. Cyclophosphamide was stopped after 2 months and replaced by azatioprine while prednisone was progressively reduced. Three years after transplantation the patient has a stable serum creatinine of 1.7 mg/dL and mild proteinuria. To the best of our knowledge this is the first case of recovery from a necrotizing glomerulonephritis in a renal transplant recipient.
Campise
M
M
Divisione di Nefrologia, IRCCS Ospedale Maggiore, Milano, Italy. campise@policlinico.mi.it
Tarantino
A
A
Banfi
G
G
Ponticelli
C
C
D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000473:pathology / Q000502:physiology*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D035781:Siblings; D013997:Time Factors; D016896:Treatment Outcome
D007166:Immunosuppressive Agents