title: Extramammary Paget's disease: outcome of radiotherapy with curative intent.
abstract: Six patients with extramammary Paget's disease were treated with curative intent radiotherapy. Two of the patients had associated underlying adenocarcinoma. Radiotherapy was given as primary treatment (two patients), definitive treatment for postexcisional relapse (three patients) and adjuvant treatment (one patient). Radiotherapy techniques included high dose rate mould brachytherapy, electron beam, superficial X-ray and photon treatments. Follow-up durations after radiotherapy were 1.2-14.8 years. Complete response was obtained in five patients while one patient had a partial response. Marginal failure occurred in one complete-responder who was successfully salvaged by surgery. The two patients with underlying adenocarcinoma died of distant metastasis. Radiotherapy side effects were acute confluent wet desquamation and mild late skin atrophy. Our results confirmed the useful role of radiotherapy in the management of extramammary Paget's disease.
authors.affiliation: Social Hygiene Service, Department of Health, Hong Kong SAR, China. tommyluk@hotmail.com
authors.forename: N M
authors.initials: NM
authors.lastname: Luk
authors.forename: K H
authors.initials: KH
authors.lastname: Yu
authors.forename: W K
authors.initials: WK
authors.lastname: Yeung
authors.forename: C L
authors.initials: CL
authors.lastname: Choi
authors.forename: M L
authors.initials: ML
authors.lastname: Teo
mesh_terms: D000008:Abdominal Neoplasms / Q000532:radiotherapy*; D000230:Adenocarcinoma / Q000532:radiotherapy*; D000328:Adult; D000368:Aged; D001918:Brachytherapy; D005260:Female; D005500:Follow-Up Studies; D005834:Genital Neoplasms, Male / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000532:radiotherapy*; D011829:Radiation Dosage; D011878:Radiotherapy / Q000009:adverse effects; D017211:Treatment Failure; D014846:Vulvar Neoplasms / Q000532:radiotherapy*