title: Kinetics of L-lysine fermentation: a continuous culture model incorporating oxygen uptake rate.
abstract: For process design and optimization, it is essential to have a mathematical model that represents the system well. Many past studies do not go beyond empirically fitting experimental data. In the present study, an unstructured model incorporating oxygen uptake and dissolved oxygen concentration was developed for a continuous culture of L-lysine. Specific rate expressions of cell growth, substrate consumption, product formation, and oxygen uptake were developed and incorporated in the model. The model predicts very well the effects of operational parameters, such as the dilution rate and the feed substrate concentration. It is also able to predict the unsteady-state dynamics of continuous L-lysine fermentation.
authors.affiliation: Department of Chemical Engineering and Materials Science, University of California, 916 Engineering Tower, Irvine, CA 92697-2575, USA. semsi.ensari@spcorp.com
authors.forename: S
authors.initials: S
authors.lastname: Ensari
authors.forename: H C
authors.initials: HC
authors.lastname: Lim
mesh_terms: D019149:Bioreactors; D003352:Corynebacterium / Q000378:metabolism; D003470:Culture Media; D005285:Fermentation; D007700:Kinetics; D008239:Lysine / Q000378:metabolism*; D008954:Models, Biological; D008962:Models, Theoretical; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption
chemical_list: D003470:Culture Media; D008239:Lysine; D010100:Oxygen