Screening of Mongolian plants for influence on amylase activity in mouse plasma and gastrointestinal tube.
Mongolian plants were screened for their influence on alpha-amylase activity in mouse plasma. Methanolic extracts of Geranium pratense, Rhodiola rosea, Ribes pullchelum and Vaccinium uliginosum inhibited the enzyme activity in isolated mouse plasma by greater than 40% and the effect was concentration dependent. Vaccinium uliginosum also showed a depressive effect on elevation of postprandial blood glucose to some extent.
Kobayashi
Kyoko
K
Tohoku Pharmaceutical University, Sendai, Japan.
Baba
Eriko
E
Fushiya
Shinji
S
Takano
Fumihide
F
Batkhuu
Javzan
J
Dash
Tzezengiin
T
Sanchir
Chinbat
C
Yoshizaki
Fumihiko
F
D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000201:enzymology*; D008297:Male; D051379:Mice; D008986:Mongolia; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D028321:Plant Preparations / Q000302:isolation & purification / Q000494:pharmacology*; D018514:Plant Structures; D000516:alpha-Amylases / Q000037:antagonists & inhibitors* / Q000097:blood*
D010936:Plant Extracts; D028321:Plant Preparations; D000516:alpha-Amylases