title: Bone marrow-derived stem cells initiate pancreatic regeneration.
abstract: We show that transplantation of adult bone marrow-derived cells expressing c-kit reduces hyperglycemia in mice with streptozotocin-induced pancreatic damage. Although quantitative analysis of the pancreas revealed a low frequency of donor insulin-positive cells, these cells were not present at the onset of blood glucose reduction. Instead, the majority of transplanted cells were localized to ductal and islet structures, and their presence was accompanied by a proliferation of recipient pancreatic cells that resulted in insulin production. The capacity of transplanted bone marrow-derived stem cells to initiate endogenous pancreatic tissue regeneration represents a previously unrecognized means by which these cells can contribute to the restoration of organ function.
authors.affiliation: Robarts Research Institute, Stem Cell Biology and Regenerative Medicine, 100 Perth Drive, London, Ontario N6A 5K8, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Hess
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Matthew
authors.initials: M
authors.lastname: Martin
authors.forename: Seiji
authors.initials: S
authors.lastname: Sakano
authors.forename: David
authors.initials: D
authors.lastname: Hill
authors.forename: Brenda
authors.initials: B
authors.lastname: Strutt
authors.forename: Sandra
authors.initials: S
authors.lastname: Thyssen
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Gray
authors.forename: Mickie
authors.initials: M
authors.lastname: Bhatia
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D016026:Bone Marrow Transplantation / Q000379:methods*; D002455:Cell Division; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006943:Hyperglycemia / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D007328:Insulin / Q000378:metabolism; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D010182:Pancreatic Diseases / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D012038:Regeneration; D013311:Streptozocin; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013311:Streptozocin