Coexisting epithelioid trophoblastic tumor and choriocarcinoma of the uterus following a chemoresistant hydatidiform mole.
The epithelioid trophoblastic tumor is an unusual type of trophoblastic tumor. Herein, we describe a patient with coexisting epithelioid trophoblastic tumor and choriocarcinoma in the uterus. The patient had a history of hydatidiform mole with recurrent elevation of human chorionic gonadotrophin level that is resistant to chemotherapy. Histopathologic and immunohistochemical examination showed distinctive differences between the 2 trophoblastic tumors. The development of epithelioid trophoblastic tumor may be related to the persistence of locally invasive disease, which was unresponsive to chemotherapy. The patient responded well to surgery. The presence of an epithelioid trophoblastic tumor should be considered in chemoresistant gestational trophoblast tumor.
Shen
Dan-Hua
DH
Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong.
Khoo
Ui Soon
US
Ngan
Hextan Y S
HY
Ng
Tung-Yau
TY
Chau
Ming-Tak
MT
Xue
Wei-Cheng
WC
Cheung
Annie N Y
AN
D002822:Choriocarcinoma / Q000150:complications / Q000601:surgery; D006063:Chorionic Gonadotropin / Q000097:blood*; D019008:Drug Resistance, Neoplasm; D015622:Epithelioid Cells / Q000187:drug effects / Q000473:pathology*; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D008875:Middle Aged; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D014594:Uterine Neoplasms / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000601:surgery
D006063:Chorionic Gonadotropin