title: Understanding the age dependency of breast cancer biomarkers.
abstract: This review and study of nearly 4,000 primary breast cancers evaluates the hypothesis that human aging not only increases breast cancer incidence but also alters breast cancer biology. Clinically validated biomarkers were chosen as surrogate measures of genetic instability and tumor growth, invasiveness and metastatic potential. Our results support the premise that breast cancer clinical behavior and biology are significantly affected by patient age, but call into question key aspects of the current cancer-aging paradigm.
authors.affiliation: Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA, USA.
authors.forename: C C
authors.initials: CC
authors.lastname: Benz
authors.forename: A D
authors.initials: AD
authors.lastname: Thor
authors.forename: S
authors.initials: S
authors.lastname: Eppenberger-Castori
authors.forename: U
authors.initials: U
authors.lastname: Eppenberger
authors.forename: D
authors.initials: D
authors.lastname: Moore
mesh_terms: D000375:Aging / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002455:Cell Division; D005260:Female; D006801:Humans
chemical_list: D014408:Biomarkers, Tumor