[Integer multiple rhythm in the spontaneous beating rhythm of cardiac myocytes and its possible mechanism].
OBJECTIVE
To introduce the characteristics of the integer multiple rhythm of cultured cardiac myocytes and to explore the cause of its generation.


METHODS
Spontaneous beating rhythms of cultured cardiac myocytes were observed with photometry system and stochastic Chay model was used to simulate the experimental results.


RESULTS
Integer multiple rhythm was observed in the experiment. This kind of rhythm is similar to phenomena of sinus arrest. The integer multiple rhythm similar to that of the experiments was simulated in stochastic Chay model, and was demonstrated to be induced by the mechanism of autonomous stochastic resonance.


CONCLUSIONS
The integer multiple rhythm observed in the experiment might be generated via the effect of autonomous stochastic resonance.
Liu
Zhi-qiang
ZQ
Institute of Space Medico-Engineering, Beijing, China.
Gu
Hua-guang
HG
Yang
Ming-hao
MH
Yang
Fen
F
Fan
Shao-guang
SG
Ren
Wei
W
D000200:Action Potentials; D000818:Animals; D002478:Cells, Cultured; D008954:Models, Biological; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000166:cytology*; D032383:Myocytes, Cardiac / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar; D013269:Stochastic Processes