title: Total synthesis of both enantiomers of the macrocyclic lactone citreofuran.
abstract: Both enantiomers of the polyketide-derived lactone citreofuran (4) have been prepared. The enantiopure building blocks were obtained on a chemoenzymatic route ((S)-6) and by a chiral pool synthesis ((R)-6). The crucial step in the synthesis, a macrolactonization, was accomplished under Mitsunobu conditions.
authors.affiliation: Department für Pharmazie--Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 München, Germany.
authors.forename: Franz
authors.initials: F
authors.lastname: Bracher
authors.forename: Brigitte
authors.initials: B
authors.lastname: Schulte
mesh_terms: D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D005663:Furans; D007783:Lactones; C477980:citreofuran