Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana.
Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. Alpha- and beta-mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 microg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.
Suksamrarn
Sunit
S
Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand. sunit@swu.ac.th
Suwannapoch
Narisara
N
Phakhodee
Wong
W
Thanuhiranlert
Janthana
J
Ratananukul
Piniti
P
Chimnoi
Nitirat
N
Suksamrarn
Apichart
A
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005638:Fruit; D029762:Garcinia mangostana; D008826:Microbial Sensitivity Tests; D017368:Protein Prenylation; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D044004:Xanthones