[Neurotic disorders: clinical and biochemical comparison].
Parameters of lipid peroxidation (LP) and those of the lipid composition of membrane erythrocytes were examined in 22 patients with neurotic disorders (adaptation disorders and neurasthenia). 45 healthy donors were in the control group. The deposition of cholesterol and of lysophosphotidylcholine as well as a reduced mean level of phosphatidylethanolamine were observed in the erythrocyte membrane of patients with neuroses. An increased mean content of malonic dialdehyde and of diene conjugates in the erythrocyte membrane and reduced mean values of the activity of antioxidant catalase enzyme were detected. However, the cluster analysis made it possible to establish an intensification of LP processes only in patients with the disease duration below three months. It is not ruled out that the reason of the detected heterogeneity of changed parameters characterizing the structural-and-metabolic status of erythrocytes in patients with neurotic disorders is related with differing natures of the adaptation abilities of the body under the influence of various stress factors.
Riazantseva
N V
NV
Novitskiĭ
V V
VV
D000328:Adult; D016000:Cluster Analysis; D004910:Erythrocyte Membrane / Q000737:chemistry; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008563:Membrane Lipids / Q000737:chemistry*; D008875:Middle Aged; D009497:Neurotic Disorders / Q000097:blood*
D008563:Membrane Lipids