Chantriolides A and B, two new withanolide glucosides from the rhizomes of Tacca chantrieri.
Two new withanolide glucosides, chantriolides A (1) and B (2), were isolated from the rhizomes of Tacca chantrieri. Their structures were determined on the basis of extensive spectroscopic studies and by acid hydrolysis as (22R)-1alpha,12alpha-diacetoxy-2alpha,3alpha;6alpha,7alpha-diepoxy-27-[(beta-d-glucopyranosyl)oxy]-5alpha-hydroxy-16-oxowith-24-enolide (1) and (22R)-1alpha,12alpha-diacetoxy-2alpha,3alpha;6alpha,7alpha-diepoxy-27-[(beta-d-glucopyranosyl)oxy]-5alpha,16beta-dihydroxywith-24-enolide (2), respectively. It is notable that withanolides, which have been almost exclusively isolated from plants of the family Solanaceae to date, have been found in a species in the family Taccaceae in the present study.
Yokosuka
Akihito
A
Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Mimaki
Yoshihiro
Y
Sashida
Yutaka
Y
D027743:Dioscoreaceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D006868:Hydrolysis; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027343:Rhizome / Q000737:chemistry; D019657:Solanaceae / Q000737:chemistry; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification*
D004365:Drugs, Chinese Herbal; D005960:Glucosides; D013256:Steroids; C478732:chantriolide A; C478733:chantriolide B