title: Analysis of the mouse transcriptome for genes involved in the function of the nervous system.
abstract: We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins. We also identified previously unknown candidates for secreted neuroactive molecules. The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored.A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.
authors.affiliation: Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA. gustinci@sissa.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Gustincich
authors.forename: Serge
authors.initials: S
authors.lastname: Batalov
authors.forename: Kirk W
authors.initials: KW
authors.lastname: Beisel
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Bono
authors.forename: Piero
authors.initials: P
authors.lastname: Carninci
authors.forename: Colin F
authors.initials: CF
authors.lastname: Fletcher
authors.forename: Sean
authors.initials: S
authors.lastname: Grimmond
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hirokawa
authors.forename: Erich D
authors.initials: ED
authors.lastname: Jarvis
authors.forename: Tim
authors.initials: T
authors.lastname: Jegla
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kawasawa
authors.forename: Julianna
authors.initials: J
authors.lastname: LeMieux
authors.forename: Harukata
authors.initials: H
authors.lastname: Miki
authors.forename: Elio
authors.initials: E
authors.lastname: Raviola
authors.forename: Rohan D
authors.initials: RD
authors.lastname: Teasdale
authors.forename: Naoko
authors.initials: N
authors.lastname: Tominaga
authors.forename: Ken
authors.initials: K
authors.lastname: Yagi
authors.forename: Andreas
authors.initials: A
authors.lastname: Zimmer
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Hayashizaki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okazaki
mesh_terms: D000225:Adenine / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001923:Brain Chemistry / Q000235:genetics; D002118:Calcium / Q000502:physiology; D015220:Calcium Channels / Q000235:genetics / Q000502:physiology; D018118:Chloride Channels / Q000235:genetics / Q000502:physiology; D003596:Cytosine / Q000378:metabolism; D030541:Databases, Genetic; D019204:GTP-Binding Proteins / Q000235:genetics; D015723:Gene Library; D005796:Genes / Q000235:genetics / Q000502:physiology*; D006147:Guanine / Q000378:metabolism; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009420:Nervous System / Q000737:chemistry* / Q000378:metabolism*; D009424:Nervous System Physiological Phenomena; D019636:Neurodegenerative Diseases / Q000235:genetics; D009474:Neurons / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D009479:Neuropeptides / Q000235:genetics; D010802:Phylogeny; D011956:Receptors, Cell Surface / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics*; D019680:Trinucleotide Repeat Expansion / Q000235:genetics
chemical_list: D015220:Calcium Channels; D018118:Chloride Channels; D009479:Neuropeptides; D011956:Receptors, Cell Surface; D006147:Guanine; D003596:Cytosine; D019204:GTP-Binding Proteins; D000225:Adenine; D002118:Calcium