Addition of caspofungin to fluconazole does not improve outcome in murine candidiasis.
Caspofungin is a potent antifungal inhibiting glucan synthesis in Candida species. However, caspofungin is not 100% curative in candidiasis. Therefore, we evaluated combinations of fluconazole with caspofungin for murine candidemia. We could not show any benefit of combined therapy over individual antifungal drugs.
Graybill
John R
JR
The University of Texas Health Science Center at San Antonio, Department of Medicine, San Antonio, Texas 78229-3900, USA. jrgraybill@aol.com
Bocanegra
Rosie
R
Najvar
Laura K
LK
Hernandez
Steve
S
Larsen
Robert A
RA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002177:Candidiasis / Q000188:drug therapy*; D000077336:Caspofungin; D004359:Drug Therapy, Combination; D054714:Echinocandins; D015725:Fluconazole / Q000494:pharmacology*; D055666:Lipopeptides; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D010455:Peptides; D010456:Peptides, Cyclic
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010455:Peptides; D010456:Peptides, Cyclic; D015725:Fluconazole; D000077336:Caspofungin