Cytoskeletal motors and cargo in membrane trafficking: opportunities for high specificity in drug intervention.
Membrane trafficking comprises the directed transport of vesicle and/or organelle cargos to specific locations throughout the cell, and is primarily driven by molecular motors tracking along microtubules and microfilaments. The mechanisms by which specific motor complexes attach to their respective vesicular cargo is of great interest, and is only now starting to be unraveled. The proteins identified as links between the molecular motors and the vesicular cargo are viable drug targets and represent opportunities to regulate small groups of related proteins or even single proteins, such as receptors and transporters, at the cytosolic trafficking level. Ultimately, continued development in this area will lead to greater success in directing endocytosed drugs to the desired intracellular targets, such as the cell nucleus or the basolateral membrane.
Phelps
Mitch A
MA
Biophysics Program, The Ohio State University, Columbus, OH 43210-1291, USA.
Foraker
Amy B
AB
Swaan
Peter W
PW
D006801:Humans; D016547:Kinesins / Q000502:physiology*; D026901:Membrane Transport Proteins / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D009218:Myosins / Q000502:physiology*
D026901:Membrane Transport Proteins; D009218:Myosins; D016547:Kinesins