title: Phenotype and function of lymphocytes from the neonatal umbilical cord compared to paired maternal peripheral blood cells isolated during delivery.
abstract: In the present study, we analyzed the immunological characteristics of mononuclear cells (MNC) isolated from both neonatal umbilical cord blood (UCB) and maternal peripheral blood (MPB) during the delivery. The in vitro proliferative response of UCB T lymphocytes was significantly reduced compared to the maternal response to phytohemagglutinin A, pokeweed mitogen, and alloantigen stimulation, in correlation with the lower percentage of UCB than MPB lymphocytes, but not with that of B cells. The mean cytotoxic activity level of interleukin-2 (IL-2)-activated natural killer (NK) was higher in UCB than in MBP, whereas the percentage of CD56(+) NK cell count was similar. Our results show differences in the immune reactivity of T and B lymphocytes from neonate and adult isolated under similar physiological conditions.
authors.affiliation: The Pathology Institute, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. eisenthal@tsmc.health.gov.il
authors.forename: Avi
authors.initials: A
authors.lastname: Eisenthal
authors.forename: Avi
authors.initials: A
authors.lastname: Hassner
authors.forename: Michael
authors.initials: M
authors.lastname: Shenav
authors.forename: Shoshana
authors.initials: S
authors.lastname: Baron
authors.forename: Beatriz
authors.initials: B
authors.lastname: Lifschitz-Mercer
mesh_terms: D000328:Adult; D002455:Cell Division; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D036861:Delivery, Obstetric; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007231:Infant, Newborn; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D010641:Phenotype; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D011247:Pregnancy
chemical_list: D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens