title: Persistent amenorrhoea in weight-recovered anorexics: psychological and biological aspects.
abstract: Demographic, psychopathological and hormonal parameters of 22 women with previous anorexia nervosa (AN) presently recovered, in a state of stabilized nutritional normalization for 3 months to 2 years but with persistent amenorrhoea, and of 20 psychophysically healthy age- and sex-matched normally menstruating controls were studied. Body mass index (BMI) values did not differ in patients and controls. Psychological examination, monitored by Eating Disorder Inventory 1, Bulimic Investigation Test Edinburgh, Yale-Brown-Cornell Eating Disorder Scale, and Tridimensional Personality Questionnaire rating scales, showed the persistence of some of the psychopathological symptoms of AN. Hormonal examinations included basal plasma concentrations of follicle stimulating hormone, luteotropic hormone, estrogens (E), progesterone, thyrotropic hormone, FT(3), FT(4) (immunoradiometric assays), leptin (LEP) (enzymatic-linked-immunosorbent assay) and 24 h urinary free cortisol (immunoradiometric assay). Hormone values were the same in patients and controls, except for E and LEP levels, which were significantly lower in patients than in controls. The concentrations of the two hormones were not correlated with the BMI of the patients, but LEP values were correlated negatively with the difference between the present BMI and the preanorexic one. The values of both hormones correlated negatively with some of the psychopathological aspects typical of AN, in particular with high 'body dissatisfaction', 'ineffectiveness', and 'interpersonal distrust' and with low 'interoceptive awareness'.
authors.affiliation: Istituto di Clinica Psichiatrica, Università, SUN, Naples, Italy. francesca.brambilla4@tin.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Brambilla
authors.forename: Palmiero
authors.initials: P
authors.lastname: Monteleone
authors.forename: Francesca
authors.initials: F
authors.lastname: Bortolotti
authors.forename: Riccardo
authors.initials: R
authors.lastname: Dalle Grave
authors.forename: Patrizia
authors.initials: P
authors.lastname: Todisco
authors.forename: Angela
authors.initials: A
authors.lastname: Favaro
authors.forename: Paolo
authors.initials: P
authors.lastname: Santonastaso
authors.forename: Carla
authors.initials: C
authors.lastname: Ramacciotti
authors.forename: Roberto
authors.initials: R
authors.lastname: Paoli
authors.forename: Mario
authors.initials: M
authors.lastname: Maj
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000097:blood / Q000453:epidemiology / Q000523:psychology; D000856:Anorexia Nervosa / Q000453:epidemiology* / Q000628:therapy*; D015992:Body Mass Index; D004967:Estrogens / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D020738:Leptin / Q000097:blood; D010554:Personality Disorders / Q000175:diagnosis; D010555:Personality Inventory; D011374:Progesterone / Q000097:blood; D020127:Recovery of Function; D012008:Recurrence; D013973:Thyrotropin-Releasing Hormone / Q000097:blood; D015430:Weight Gain
chemical_list: D004967:Estrogens; D020738:Leptin; D011374:Progesterone; D013973:Thyrotropin-Releasing Hormone; D006854:Hydrocortisone