A trinuclear heterobimetallic Ru(II)/Pt(II) complex as a chemodosimeter selective for sulfhydryl-containing amino acids and peptides.
A trinuclear heterobimetallic Ru(II)/Pt(II) complex, cis-{Ru(phen)2[CN-Pt(DMSO)Cl2]2} (phen = 1,10-phenanthroline), is able to function as a "switch-on" luminescent chemodosimeter for sulfhydryl-containing amino acids and peptides via specific binding of the amino acids/peptides with the Pt(II) centers and the subsequent cleavage of the Ru(II)-Pt(II) cyano-bridge.
Chow
Cheuk-Fai
CF
Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR, China.
Chiu
Brenda K W
BK
Lam
Michael H W
MH
Wong
Wai-Yeung
WY
D000596:Amino Acids / Q000032:analysis* / Q000737:chemistry; D005470:Fluorometry; D008163:Luminescent Measurements; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010455:Peptides / Q000032:analysis* / Q000737:chemistry; D010618:Phenanthrolines / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000032:analysis* / Q000737:chemistry
D000596:Amino Acids; D009944:Organoplatinum Compounds; D010455:Peptides; D010618:Phenanthrolines; D013438:Sulfhydryl Compounds; D012428:Ruthenium