[Immunohistochemical study of thrombomodulin expression in multiple organs dysfunction syndrome].
OBJECTIVE
To study the expression of thrombomodulin (TM) and its significance in the pathogenesis of multiple organs dysfunction syndrome (MODS).


METHODS
TM expression was determined by immunohistochemical staining in 20 autopsy cases with MODS group and 12 autopsy cases without MODS (control group).


RESULTS
Significant differences in positive expression of TM in heart, lungs and kidneys were found between the control group and MODS group (all P<0.01).


CONCLUSIONS
The increase of TM secretion results in homeostatic disturbance, which might be one of the important mechanisms of MODS.
Luo
Si-min
SM
Department of Forensic Pathology, Zhongshan University of Medical Sciences, Guangzhou 510080, Guangdong, China.
Jing
Hua-lan
HL
Wu
Ri-yun
RY
Chen
Can-qiu
CQ
Jia
Xiao
X
Li
Yan-rong
YR
Wang
Yi
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000737:chemistry / Q000473:pathology; D008168:Lung / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000737:chemistry / Q000473:pathology; D011379:Prognosis; D018180:Thrombomodulin / Q000032:analysis*
D018180:Thrombomodulin