Molecular call-and-response: how Salmonella learns the gospel from its host.
Host-microbe interactions are often portrayed as a game of molecular hide-and-seek or tug-of-war where one partner seeks to establish an upper-hand over the other. Perhaps a more useful analogy is the traditional call-and-response preaching method used so effectively in churches of the southern USA to encourage participation by the assembled parishioners. The preacher calls out a line of a gospel or hymn and the congregation responds as one to the cue. A recent paper identifies Nramp as a potential molecular preacher, and Salmonella, and probably other pathogenic bacteria, are singing back full-throated.
Dangl
Jeffery L
JL
Department of Biology, Curriculum in Genetics, Dept of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA. dangl@email.unc.edu
D000818:Animals; D027682:Cation Transport Proteins / Q000235:genetics / Q000378:metabolism; D008264:Macrophages / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D012480:Salmonella Infections / Q000235:genetics / Q000276:immunology / Q000382:microbiology*; D012481:Salmonella Infections, Animal / Q000235:genetics / Q000276:immunology; D012486:Salmonella typhimurium / Q000235:genetics / Q000472:pathogenicity*; D014774:Virulence; D037521:Virulence Factors / Q000235:genetics; D000099173:Natural Resistance-associated Macrophage Protein 1
D027682:Cation Transport Proteins; D037521:Virulence Factors; D000099173:Natural Resistance-associated Macrophage Protein 1