Carvedilol, a beta adrenoceptor blocker with chelating properties. A copper 'superdimer' based on dimetal units.
Copper(II) complexes of carvedilol molecule, (CARVH): 1-[carbazolyl-(4)-oxyl]-3-[(2-methoxyphenoxyethyl)-amino]-2-propanol, were synthesized and characterized with respect to their structural and spectroscopic properties. The crystal structure of [Cu(Carv)Cl(MeOH)](2).4MeOH complex revealed that the molecule chelates two Cu(II) ions via the N and O atoms belonging to the amino and propanol moiety, respectively. The coordination behaviour of carvedilol studied by 1H nuclear magnetic resonance (NMR, 1-D and 2-D-COSY) spectroscopy in dimethyl sulfoxide solution at room temperature, allowed us to obtain structural information and to identify the donor atoms involved in the coordination process in solution.
Zoroddu
Maria Antonietta
MA
Dipartimento di Chimica, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy. zoroddu@uniss.it
Grepioni
Fabrizia
F
Franconi
Flavia
F
D000319:Adrenergic beta-Antagonists / Q000737:chemistry* / Q000494:pharmacology*; D002227:Carbazoles / Q000737:chemistry* / Q000494:pharmacology*; D000077261:Carvedilol; D002614:Chelating Agents / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000378:metabolism*; D003460:Crystallization; D019281:Dimerization; D004578:Electron Spin Resonance Spectroscopy; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D011412:Propanolamines / Q000737:chemistry* / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D002614:Chelating Agents; D011412:Propanolamines; D000077261:Carvedilol; D003300:Copper