Transplantation: tolerance.
The immunosuppressive regimens currently in use have been responsible for major improvements in transplanted organ acceptance, but long-term survival can be compromised by drug toxicity and/or chronic immune deficiency. The ultimate goal for transplantation is tolerance, defined as durable, donor-specific allograft acceptance in the absence of long-term immunosuppression. This review describes current experimental strategies for tolerance induction in primate models that are poised for clinical application.
Hutchings
Anne
A
Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA. ahutchings@uab.edu
Thomas
Judith M
JM
D000818:Animals; D006084:Graft Rejection / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D023001:Transplantation Tolerance / Q000187:drug effects* / Q000276:immunology*
D007166:Immunosuppressive Agents