title: Isolation and characterization of a human putative receptor protein kinase cDNA STYK1.
abstract: Protein kinases (PKs) represent a well studied but most diverse protein superfamily. The covalent, reversible linkage of phosphate to serine, threonine, and tyrosine residues of substrate proteins by protein kinases is probably ubiquitous cellular mechanism for regulation of physiological processes. It is known to us that most signaling pathways impinge at some point on protein kinases. Here we report a human putative receptor protein kinase cDNA STYK1. The STYK1 cDNA is 2749 base pairs in length and contains an open reading frame encoding 422 amino acids. The STYK1 gene is mapped to human chromosome 12p13 and 11 exons were found. RT-PCR showed that STYK1 is widely expressed in human tissues.
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Ye
authors.forename: Chaoneng
authors.initials: C
authors.lastname: Ji
authors.forename: Qingshan
authors.initials: Q
authors.lastname: Huang
authors.forename: Chao
authors.initials: C
authors.lastname: Cheng
authors.forename: Rong
authors.initials: R
authors.lastname: Tang
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Zeng
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Dai
authors.forename: Qihan
authors.initials: Q
authors.lastname: Wu
authors.forename: Shaohua
authors.initials: S
authors.lastname: Gu
authors.forename: Yi
authors.initials: Y
authors.lastname: Xie
authors.forename: Yumin
authors.initials: Y
authors.lastname: Mao
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D018076:DNA, Complementary / Q000737:chemistry / Q000302:isolation & purification; D005091:Exons; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
chemical_list: D018076:DNA, Complementary; D012333:RNA, Messenger; D020794:Receptor Protein-Tyrosine Kinases; C482299:STYK1 protein, human; D017346:Protein Serine-Threonine Kinases