Novel synthesis of heterocycles having a functionalized carbon center via nickel-mediated carboxylation: total synthesis of erythrocarine.
Novel synthetic procedure of heterocycles was developed using nickel-mediated alkylative carboxylation, and the total synthesis of erythrocarine was achieved using this method and RCM of dienyne as the key steps. [reaction: see text]
Shimizu
Kazuya
K
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Takimoto
Masanori
M
Mori
Miwako
M
D000470:Alkaloids / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D004895:Erythrina / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis*; D009532:Nickel / Q000737:chemistry*
D000470:Alkaloids; D000480:Alkynes; D006571:Heterocyclic Compounds; D006576:Heterocyclic Compounds, 4 or More Rings; C478876:erythrocarine; D009532:Nickel