title: Successful repair of aortic and mitral incompetence induced by methylsergide maleate: confirmation by intraoperative transesophageal echocardiography.
abstract: Methylsergide maleate, an effective anti-migraine medication, has a well-documented association with left-sided cardiac valve dysfunction. Prior reports have described cardiac valve dysfunction in patients using methylsergide chronically for a minimum of 6 years, with surgical intervention consisting of valve replacement for patients with intractable congestive heart failure. We report a 51-year-old woman who developed severe mitral and aortic valvular dysfunction after taking methylsergide maleate for migraine headaches for a period of 19 months, and who subsequently underwent aortic and mitral valve repair with excellent short-term results.
authors.affiliation: North Shore University Hospital, New York University School of Medicine, Manhasset, New York, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Joseph
authors.forename: Stanley K C
authors.initials: SK
authors.lastname: Tam
authors.forename: Brinda R
authors.initials: BR
authors.lastname: Kamat
authors.forename: Judy R
authors.initials: JR
authors.lastname: Mangion
mesh_terms: D001021:Aortic Valve / Q000601:surgery; D001022:Aortic Valve Insufficiency / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D017548:Echocardiography, Transesophageal; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008784:Methysergide / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy; D008943:Mitral Valve / Q000601:surgery; D008944:Mitral Valve Insufficiency / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D012702:Serotonin Antagonists / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D012702:Serotonin Antagonists; D008784:Methysergide