title: Matrix reloaded to circulation hits the tumor target.
abstract: Proteolytic fragments of various components of the extracellular matrix exhibit antiangiogenic activity via interaction with endothelial cell surface integrins. Kalluri and coworkers (this issue of Cancer Cell) use gene-targeted mice to show a physiological role for a carboxy-terminal fragment of collagen IV in the regulation of tumor angiogenesis.
authors.forename: Sara A
authors.initials: SA
authors.lastname: Wickström
authors.forename: Jorma
authors.initials: J
authors.lastname: Keski-Oja
authors.forename: Kari
authors.initials: K
authors.lastname: Alitalo
mesh_terms: D000818:Animals; D024141:Collagen Type IV / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000378:metabolism*
chemical_list: D024141:Collagen Type IV; D020780:Matrix Metalloproteinase 9