Neuropeptide Y, left ventricular mass and function in patients with end stage renal disease.
OBJECTIVE
Neuropeptide Y (NPY) is released during sympathetic stimulation and mediates the central effects of the adipostatic hormone leptin. The plasma concentration of NPY and leptin is increased in patients with end stage renal disease (ESRD), but it is unknown whether these substances are related to biochemical markers of sympathetic activity and to alterations in left ventricular (LV) mass and function in these patients.


METHODS
We investigated the relationship between NPY, norepinephrine (NE), leptin and echocardiographic measurements in a cross-sectional study in 198 patients with ESRD.


RESULTS
NPY was directly related to plasma NE and heart rate but it was largely independent of arterial pressure and of retention of metabolic waste products. NPY was significantly higher in patients with LV hypertrophy and in those with LV systolic dysfunction than in those without these alterations. Of note, NPY emerged as an independent correlate of LV mass index and of LV ejection fraction (LVEF) (both P <or= 0.002) in multiple linear regression analyses including a series of cardiovascular risk factors. Furthermore in a multiple logistic regression model patients in the top NPY tertile had a risk for LV concentric hypertrophy that was 18.10 (95% confidence interval: 5.87-55.83) times higher than in those in the first tertile (P < 0.001). Leptin was unrelated to NPY as well as to LV mass and to systolic function.


CONCLUSIONS
Elevated NPY is independently associated with LV concentric hypertrophy and systolic dysfunction in ESRD. It remains to be seen whether these links contribute to the high cardiovascular mortality in these patients.
Zoccali
Carmine
C
CNR, Institute of Biomedicine, Epidemiology and Pathophysiology of Renal Diseases and Hypertension and Division of Nephrology, Morelli Hospital, Reggio Calabria, Italy. carmine.zoccali@tin.it
Mallamaci
Francesca
F
Tripepi
Giovanni
G
Benedetto
Francesco A
FA
Parlongo
Saverio
S
Cutrupi
Sebastiano
S
Bonanno
Graziella
G
Rapisarda
Francesco
F
Fatuzzo
Pasquale
P
Seminara
Giuseppe
G
Cataliotti
Alessandro
A
Malatino
Lorenzo S
LS
D000328:Adult; D000368:Aged; D015415:Biomarkers; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000378:metabolism*; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D009478:Neuropeptide Y / Q000097:blood*; D009638:Norepinephrine / Q000097:blood; D012307:Risk Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology
D015415:Biomarkers; D020738:Leptin; D009478:Neuropeptide Y; D009638:Norepinephrine