[The clinical and pathological changes following anterior-ethmoid neurotomy in treating perennial allergic rhinitis with plasma].
OBJECTIVE
To research the therapy effect of perennial allergic rhinitis (PAR) with anterior-ethmoid neurotomy, and to observe the pathological changes of SP nerve fibres.


METHODS
In 46 cases (neurotomy group, NG) of PAR anterior-ethmoid neurotomy were performed, the surgery effect was evaluated according to the Chinese Hai Kou allergic rhinitis diagnosis and curative access standard (1997) and compared with 17 cases simulating operation without neurotomy (non-neurotomy group, NNG) by clinical symptoms controlled counting-scores. The substance P in nasal mucous membrane of NG was observed with immunohistochemical test, meanwhile the square of positive-stained nerve fibres on the sections were measured with a quantitative analysis method after and before operation, which also were compared with that of 14 cases patients without rhinopathy (normal controlled group, NCG).


RESULTS
The average score reduced from 12.93 pre-operation to 6.14 post-operation (P < 0.01) in NG, but in NNG there is no significant different before and after therapy. The squares of SP immune response (SP-IR) positive-stained fibers were significant different between pre-operation and post-operation in NG. The quantities of SP-IR positive-stained fibers in nasal mucous membrane were more in PAR patients (before operation) that that in the NCG.


CONCLUSIONS
The anterior-ethmoid neurotomy with plasm technique is an effective and simple therapical method for treating PAR. The SP of anterior--ethmoid nerve plays an important role in the pathological mechanism of PAR.
Feng
Liren
L
Department of Otorhinolaryngology, Affiliated Zhongda Hospital, Southeast University, Nanjing 210009.
Yu
Lanqing
L
Ying
Haiyue
H
Guo
Qingming
Q
Tan
Changqiang
C
D000293:Adolescent; D000328:Adult; D005005:Ethmoid Sinus / Q000294:innervation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000294:innervation / Q000473:pathology; D019635:Neurosurgical Procedures / Q000379:methods; D010275:Parasympathetic Nervous System / Q000601:surgery*; D012221:Rhinitis, Allergic, Perennial / Q000473:pathology / Q000601:surgery*; D013373:Substance P / Q000378:metabolism
D013373:Substance P