Difficulties in stratifying neuropathic pain by mechanisms.
The paper addresses issues related to the clinical relevance of currently employed animal models of neuropathic pain and our inability to translate clinical symptoms and signs into pathophysiological mechanisms. A mechanism-based classification of pain is therefore currently not feasible. Suggestions on how to facilitate progress within this area are put forward.
Hansson
Per
P
Department of Surgical Sciences, Section of Clinical Pain Research and Neurogenic Pain Unit, Multidisciplinary Pain Center, Karolinska Institute/Hospital, Stockholm 171 76, Sweden. per.hansson@kirurgi.ki.se
D000818:Animals; D001522:Behavior, Animal; D004195:Disease Models, Animal; D006801:Humans; D009422:Nervous System Diseases / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D010146:Pain / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*