Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae.
Leptin is a pleiotropic hormone-cytokine known to regulate energy homeostasis and immune function. Neutrophils from leptin-deficient mice exhibited impaired phagocytosis of Klebsiella pneumoniae opsonized with serum containing complement and reduced CD11b expression that could be restored with exogenous leptin. These results suggest that leptin is required for normal neutrophil complement-mediated phagocytosis of bacteria.
Moore
Sharlene I
SI
Program in Human Nutrition, University of Michigan, Ann Arbor, Michigan 48109, USA.
Huffnagle
Gary B
GB
Chen
Gwo-Hsiao
GH
White
Eric S
ES
Mancuso
Peter
P
D000818:Animals; D039481:CD11b Antigen / Q000032:analysis; D005260:Female; D007711:Klebsiella pneumoniae / Q000276:immunology*; D020738:Leptin / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D017452:Receptors, IgG / Q000032:analysis; D054411:Receptors, Leptin
D039481:CD11b Antigen; D020738:Leptin; D017452:Receptors, IgG; D054411:Receptors, Leptin; C515447:leptin receptor, mouse