Improvement of norfloxacin oral bioavailability by EDTA and sodium caprate.
The EDTA and sodium caprate (Na caprate) effects on the oral bioavailability of norfloxacin were tested. It was found that absorption kinetic of norfloxacin was markedly accelerated when mixed with EDTA or Na caprate in a ratio of 1:1. When mixed with the absorption enhancers in a ratio of 1:5, only Na caprate improved norfloxacin bioavailability significantly. In vitro dissolution tests demonstrated that EDTA and Na caprate increased norfloxacin dissolution kinetic. However, the correlation between bioavailability and in vitro dissolution improvement was not clearly established. So, we can conclude that the solubilizing property of EDTA and Na caprate did not take a prominent part in norfloxacin absorption.
Dos Santos
I
I
Laboratoire de Pharmacie Galénique et Biopharmacie, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. isabelle.dossantos@galbio.u-bordeaux2.fr
Fawaz
F
F
Lagueny
A M
AM
Bonini
F
F
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002614:Chelating Agents / Q000737:chemistry / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D003652:Decanoic Acids / Q000737:chemistry / Q000494:pharmacology*; D004357:Drug Synergism; D004492:Edetic Acid / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D009643:Norfloxacin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits; D012995:Solubility
D002614:Chelating Agents; D003652:Decanoic Acids; C031071:decanoic acid; D004492:Edetic Acid; D009643:Norfloxacin