title: Phylogenetic analysis of the mammalian Hoxc8 non-coding region.
abstract: The non-coding intergenic regions of Hox genes are remarkably conserved among mammals. To determine the usefulness of this sequence for phylogenetic comparisons, we sequenced an 800-bp fragment of the Hoxc9-Hoxc8 intergenic region from several species belonging to different mammalian clades. Results obtained from the phylogenetic analysis are congruent with currently accepted mammalian phylogeny. Additionally, we found a TC mini satellite repeat polymorphism unique to felines. This polymorphism may serve as a useful marker to differentiate between mammalian species or as a genetic marker in feline matings. This study demonstrates usefulness of a comparative approach employing non-coding regions of Hox gene complexes.
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, Yale University, PO Box 208103, New Haven, CT 06520, USA.
authors.forename: Chang-Bae
authors.initials: CB
authors.lastname: Kim
authors.forename: Cooduvalli S
authors.initials: CS
authors.lastname: Shashikant
authors.forename: Kenta
authors.initials: K
authors.lastname: Sumiyama
authors.forename: Wayne C H
authors.initials: WC
authors.lastname: Wang
authors.forename: Chris T
authors.initials: CT
authors.lastname: Amemiya
authors.forename: Frank H
authors.initials: FH
authors.lastname: Ruddle
mesh_terms: D000818:Animals; D021901:DNA, Intergenic; D004742:Enhancer Elements, Genetic; D019143:Evolution, Molecular; D014644:Genetic Variation; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008322:Mammals / Q000235:genetics*; D010802:Phylogeny; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA
chemical_list: D021901:DNA, Intergenic; C489815:HOXC8 protein, human; D018398:Homeodomain Proteins; C080041:Hoxc6 protein, mouse