Emerging parallels in the generation and regeneration of skeletal muscle.
Previously, skeletal muscle regeneration appeared to be very different from embryonic specification of muscle, but in this issue of Cell, Polesskaya et al. show that Wnt signaling induces myogenesis in adult muscle stem cells in a manner analogous to muscle induction in the somite.
Snider
Lauren
L
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
Tapscott
Stephen J
SJ
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D019070:Cell Lineage / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D018485:Muscle Fibers, Skeletal / Q000166:cytology / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D051763:PAX7 Transcription Factor; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D012038:Regeneration / Q000235:genetics*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism*; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D018398:Homeodomain Proteins; D051763:PAX7 Transcription Factor; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins