Condensin and cohesin: more than chromosome compactor and glue.
Two related protein complexes, cohesin and condensin, are essential for separating identical copies of the genome into daughter cells during cell division. Cohesin glues replicated sister chromatids together until they split at anaphase, whereas condensin reorganizes chromosomes into their highly compact mitotic structure. Unexpectedly, mutations in the subunits of these complexes have been uncovered in genetic screens that target completely different processes. Exciting new evidence is emerging that cohesin and condensin influence crucial processes during interphase, and unforeseen aspects of mitosis. Each complex can perform several roles, and individual subunits can associate with different sets of proteins to achieve diverse functions, including the regulation of gene expression, DNA repair, cell-cycle checkpoints and centromere organization.
Hagstrom
Kirsten A
KA
Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720-3204, USA. kirstenh@uclink.berkeley.edu
Meyer
Barbara J
BJ
D000251:Adenosine Triphosphatases / Q000502:physiology*; D000818:Animals; D018797:Cell Cycle Proteins; D002843:Chromatin / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone; D004261:DNA Replication / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology*; D005656:Fungal Proteins; D006801:Humans; D046912:Multiprotein Complexes; D009687:Nuclear Proteins / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D000097722:Cohesins
D000251:Adenosine Triphosphatases; D018797:Cell Cycle Proteins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D046912:Multiprotein Complexes; D009687:Nuclear Proteins; D000097722:Cohesins; C108312:condensin complexes