[The role of papilloma virus in development of cervix precancer and cancer (a literature review)].
There are now enough data confirming the causal relationship between the papilloma-virus infection and the lesion of the neck of uterus. Virtually all dysplasias contain the human papilloma virus either as an infection virion or as episome-type or integrated DNA. The chronic papilloma-virus infection of high risk is an indispensable precondition for creating a precancerous and malignant phenotypes. However, considering the human papilloma-virus infection to be the key risk factor of precancerosis and cervical carcinoma, one should not fail to take into account other impacts. The clinical infection signs result from an interaction of a number of factors, like virus type, human immune and hormonal systems, other infection types as well as human behavior (sex activity, smoking, alcohol etc.). Because of the infection transmission nature and its extensive spreading, its treatment is related with certain difficulties. Therefore, the radical treatment of infection consequences (pathologies of the neck of uterus) must be in the focus of attention, which, in the end, would ensure success in coping with the infection. The immunological methods deserve attention, however, they are still in the experimental stage.
Podistov
Iu I
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D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology*; D011230:Precancerous Conditions / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D014412:Tumor Virus Infections / Q000150:complications / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000628:therapy / Q000821:virology*