Bordetella bronchiseptica persists in the nasal cavities of mice and triggers early delivery of dendritic cells in the lymph nodes draining the lower and upper respiratory tract.
Early after the intranasal instillation of Bordetella bronchiseptica into mice, not only are mature dendritic leukocytes recovered from lung parenchyma and bronchoalveolar lavage fluid but their numbers are also increased in the mediastinal lymph nodes and the nasal mucosa-associated lymphoid tissue. Later during the infectious process, the bacteria persist mainly in the nasal cavity.
Gueirard
Pascale
P
Unité des Bordetella, Institut Pasteur, Paris, France. pgueirar@pasteur.fr
Ave
Patrick
P
Balazuc
Anne-Marie
AM
Thiberge
Sabine
S
Huerre
Michel
M
Milon
Genevieve
G
Guiso
Nicole
N
D000818:Animals; D016950:Bordetella bronchiseptica / Q000502:physiology*; D039521:CD11c Antigen / Q000032:analysis; D002465:Cell Movement; D003713:Dendritic Cells / Q000502:physiology*; D005260:Female; D007962:Leukocytes / Q000276:immunology; D008168:Lung / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009296:Nasal Cavity / Q000382:microbiology*
D039521:CD11c Antigen