RNA folding: models and perspectives.
Intrinsic events during RNA folding include conformational search and metal ion binding. Several experimentally testable models have been proposed to explain how large ribozymes accomplish folding. Future challenges include the validation of these models, and the correlation of experimental results and theoretical simulations.
Sosnick
Tobin R
TR
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA. trsosnic@midway.uchicao.edu
Pan
Tao
T
D007700:Kinetics; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000378:metabolism*; D016337:RNA, Catalytic / Q000378:metabolism*
D016337:RNA, Catalytic; D012313:RNA