Outbreak of carbapenem-resistant Acinetobacter baumannii producing the OXA-23 enzyme in Curitiba, Brazil.
Carbapenem-resistant Acinetobacter baumannii isolates were obtained from eight patients in two hospitals in Curitiba, Brazil. The isolates were multiresistant, belonged to a single strain, and produced the OXA-23 carbapenemase. Treatment options were limited, although the isolates were susceptible to polymyxin B in vitro. The strain contributed to the deaths of five patients.
Dalla-Costa
Libera M
LM
Hospital de Clínicas da Universidade Federal do Paraná (HC), Curitiba, Brazil.
Coelho
Juliana M
JM
Souza
Helena A P H M
HA
Castro
Maria E S
ME
Stier
Christiane J N
CJ
Bragagnolo
Karin L
KL
Rea-Neto
Alvaro
A
Penteado-Filho
Sergio R
SR
Livermore
David M
DM
Woodford
Neil
N
D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000201:enzymology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D015780:Carbapenems / Q000494:pharmacology*; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D006784:Hospitals, Teaching; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D001618:beta-Lactamases / Q000378:metabolism*
D015780:Carbapenems; C466679:beta-lactamase OXA-23; D001618:beta-Lactamases