Quality of dietary fatty acids, insulin sensitivity and type 2 diabetes.
Epidemiological evidence and intervention studies clearly indicate that the quality of dietary fat influences insulin sensitivity in humans, in particular, saturated fat worsens it, while monounsaturated and omega-6 polyunsaturated fats improve it. Long chain omega-3 fatty acids do not seem to have any effect on insulin sensitivity, at least in humans. Moreover, there is also good epidemiological evidence that the quality of dietary fat may influence the risk of type 2 diabetes, again with saturated fat increasing and unsaturated fat decreasing this risk. No intervention study is available at the moment on this specific point, even if in the Finnish Diabetes Prevention Study the incidence of type 2 diabetes was reduced by a multifactorial intervention, which also included a reduction of saturated fat intake.
Rivellese
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Department of Clinical and Experimental Medicine, Federico II University, Medical School, Via Sergio Pansini, 5-80131, Naples, Italy. rivelles@unina.it
Lilli
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D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000209:etiology; D004041:Dietary Fats / Q000009:adverse effects* / Q000494:pharmacology; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology; D006801:Humans; D007333:Insulin Resistance; D012307:Risk Factors
D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated