title: Aqueous extract of Monascus purpureus M9011 prevents and reverses fructose-induced hypertension in rats.
abstract: This study aimed to determine the antihypertensive and metabolic effects of an aqueous extract of Monascus purpureus M9011 on fructose-induced hypertensive rats. After dietary feeding of fructose for 2 weeks, the rats exhibited significantly higher systolic blood pressure (SBP), mean arterial pressure (MAP), and plasma insulin and triglyceride levels, but lower insulin sensitivity than those in control rats on regular diet. The intragastric loading of fructose-fed rats with M9011 containing gamma-aminobutyric acid (GABA, 1 mg.kg(-)(1).day(-)(1)) prevented the development of fructose-induced hypertension. After fructose-induced hypertension had been established, intragastric loading of M9011 reversed the elevated blood pressure to normal level. Administration of pure GABA at the same dose as that contained in M9011 failed to prevent or reverse hypertension due to fructose consumption. Chronic M9011 treatment significantly suppressed the fructose-induced elevation in total cholesterol levels and enhanced the recovery of high-density lipoprotein cholesterol/total cholesterol ratio. However, M9011 treatment did not alter insulin sensitivity or the plasma levels of insulin, glucose, and triglyceride in fructose-fed and control rats. The present results suggest that M9011 is a novel, potent, food-based antihypertensive agent with the capability to improve long-term control of cholesterol metabolism in rats and may be of importance in clinical application for the hypertensive diabetic population.
authors.affiliation: Department of Physiology and Biophysics, National Defense Medical Center, National Defense University, Taipei, Taiwan, Republic of China. pshsieh@hotmail.com
authors.forename: Po-Shiuan
authors.initials: PS
authors.lastname: Hsieh
authors.forename: Yueh-Hua
authors.initials: YH
authors.lastname: Tai
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005632:Fructose; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D032741:Monascus / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D010936:Plant Extracts; D014280:Triglycerides; D005632:Fructose; D005680:gamma-Aminobutyric Acid; D002784:Cholesterol