Sarcomatous transformation of prostatic adenocarcinoma after radio- and chemotherapy.
We report a case of a sarcomatous transformation of a prostatic adenocarcinoma after radiotherapy and chemotherapy. The sarcomatous tumor showed features of myogenic differentiation. DNA flow cytometry demonstrated a change in the DNA ploidy, from a diploid pattern in the adenocarcinoma, to an aneuploid pattern in the sarcoma. This is the first report of a prostatic sarcomatous tumor studied in this way. Review of medical literature revealed five additional cases of prostatic adenocarcinoma undergoing sarcomatous transformation following radiotherapy with or without chemotherapy or hormonal therapy.
Mai
K T
KT
Pathology and Laboratory Medicine, University of Ottawa, Ottawa Ontario.
Gerridzen
R G
RG