title: [Luteinized cystic ovarian hyperplasia during a normal pregnancy].
abstract: Hyperreactio luteinalis (HRL) is rarely observed in normal pregnancy. Its clinical spectrum consists of benign development of often bilateral lutein cysts and may be revealed by an overproduction of androgens. HRL is more often in relation with an excessive production of human chorionic gonadotropin (hCG) either in trophoblastic disease or in hyperplacentosis (Rh-alloimmunization or diabetes), but in 60% of the cases HRL may occur in normal singleton pregnancies. Many benign or malignant ovarian lesions can mimic HRL during pregnancy. The pathophysiology of HRL in singleton pregnancies involves an increased sensitivity of ovarian stromal cells to hCG. A positive ovarian stimulation test with hCG, recommended three months after delivery may detect a recurrence risk for further pregnancies. Conservative treatment is advised and surgery must be reserved for maternal complications.
authors.affiliation: Service d'Obstétrique et Médecine Foetale, CHU de Nantes, 7, quai Moncousu, 44093 Nantes Cedex 1.
authors.forename: C
authors.initials: C
authors.lastname: Le Vaillant
authors.forename: C
authors.initials: C
authors.lastname: Tremouilhac
authors.forename: G
authors.initials: G
authors.lastname: Boog
mesh_terms: D000328:Adult; D000728:Androgens / Q000502:physiology; D006063:Chorionic Gonadotropin / Q000502:physiology; D003937:Diagnosis, Differential; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006965:Hyperplasia; D007231:Infant, Newborn; D034461:Luteinization; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010048:Ovarian Cysts / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D010053:Ovary / Q000473:pathology*; D010062:Ovulation Induction; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D011254:Pregnancy in Diabetics / Q000150:complications; D012008:Recurrence; D012203:Rh Isoimmunization / Q000150:complications; D012307:Risk Factors; D018245:Trophoblastic Tumor, Placental Site / Q000150:complications; D016216:Ultrasonography, Prenatal
chemical_list: D000728:Androgens; D006063:Chorionic Gonadotropin; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone