Kinetics of diltiazem hydrochloride in solid phase.
The influence of temperature (353, 358, 363, 368, and 373 K) and relative humidity (76.4, 66.5, 60.5 and 50.9% RH) on the stability of diltiazem hydrochloride in the solid phase was investigated. The decomposition was followed by a HPLC method with UV detection. The kinetic (rate constants, t0.1 and t0.5) and thermodynamic parameters (energy, entalpy and entropy of activation) of the degradation of diltiazem hydrochloride were calculated.
Muszalska
Izabela
I
Department of Pharmaceutical Chemistry, K. Marcinkowski University of Medical Sciences, 6 Grunwaldzka Str., 60-780 Poznań, Poland.
Siakowski
Maciej
M
D000465:Algorithms; D002121:Calcium Channel Blockers / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004110:Diltiazem / Q000737:chemistry*; D004355:Drug Stability; D006813:Humidity; D007202:Indicators and Reagents; D007700:Kinetics; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics
D002121:Calcium Channel Blockers; D007202:Indicators and Reagents; D004110:Diltiazem