[Effect of removal of the adventitia on vascular remodeling and vasoconstriction in rabbits].
The aim of the present study was to investigate the effect of removal of the adventitia on vascular remodeling and vasoconstriction of the carotid artery in New Zealand rabbit. Adventitia of carotid artery was removed mechanically. The histology, morphology and reactivity of the carotid artery was observed by immunohistochemistry and measurement of carotid ring tension immediately, 1 week and 2 weeks after removal of the adventitia. No damage of intima and media was observed after removing the adventitia. Removal of the adventitia caused a remarkable proliferation of the vascular media and formed the neointima. Compared with the control ring, norepinephrine (NE)-induced vasocontraction in adventitia-denuded carotid artery was significantly reduced immediately and 1 week after the operation (P<0.05). Adventitia removal promoted the neointima formation and decreased vasoconstriction of the carotid artery, indicating that the adventitia is involved in the regulation of vascular remodeling and vasoconstriction.
Mu
Hua-Ming
HM
Department of Hypertension and Endocrinology, Chongqing Hypertension Institute, Daping Hospital, Third Military Medical University, Chongqing 400042.
Zhu
Zhi-Ming
ZM
Wang
Hai-Yan
HY
Wang
Li-Juan
LJ
D000818:Animals; D002339:Carotid Arteries / Q000473:pathology / Q000502:physiology / Q000601:surgery; D003238:Connective Tissue / Q000502:physiology* / Q000601:surgery; D009131:Muscle, Smooth, Vascular / Q000473:pathology*; D011817:Rabbits; D017539:Tunica Intima / Q000473:pathology*; D014661:Vasoconstriction / Q000502:physiology*