Association between A2a receptor gene polymorphisms and caffeine-induced anxiety.
The adenosine receptor system, which mediates the psychoactive effects of caffeine, is also thought to be involved in the regulation of anxiety. In this study, we examined the association between variations in anxiogenic responses to caffeine and polymorphisms in the A1 and A2a adenosine receptor genes. Healthy, infrequent caffeine users (N=94) recorded their subjective mood states following a 150 mg oral dose of caffeine freebase or placebo in a double-blind study. We found a significant association between self-reported anxiety after caffeine administration and two linked polymorphisms on the A2a receptor gene, the 1976C>T and 2592C>Tins polymorphisms. Individuals with the 1976T/T and the 2592Tins/Tins genotypes reported greater increases in anxiety after caffeine administration than the other genotypic groups. The study shows that an adenosine receptor gene polymorphism that has been associated with Panic Disorder is also associated with anxiogenic responses to an acute dose of caffeine.
Alsene
Karen
K
Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA.
Deckert
Jürgen
J
Sand
Philipp
P
de Wit
Harriet
H
D000328:Adult; D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000235:genetics*; D002110:Caffeine / Q000009:adverse effects*; D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D003545:Cysteine / Q000235:genetics; D004311:Double-Blind Method; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D006823:Hybrid Vigor / Q000187:drug effects; D008297:Male; D009483:Neuropsychological Tests; D010147:Pain Measurement / Q000379:methods; D010555:Personality Inventory; D011110:Polymorphism, Genetic; D043705:Receptor, Adenosine A2A; D018047:Receptors, Purinergic P1 / Q000187:drug effects / Q000235:genetics*; D017422:Sequence Analysis, DNA; D020080:Tandem Repeat Sequences / Q000187:drug effects; D013912:Threonine / Q000235:genetics; D013997:Time Factors
D000697:Central Nervous System Stimulants; D043705:Receptor, Adenosine A2A; D018047:Receptors, Purinergic P1; D013912:Threonine; D002110:Caffeine; D003545:Cysteine