HLA-DRB1 gene polymorphism in patients with dilated cardiomyopathy.
To probe into the genetic background and immunopathogenesis of dilated cardiomyopathy (DCM), HLA-DRB1 gene polymorphism in 68 patients with DCM and 175 normal control subjects were analyzed by using the polymerase chain reaction/sequence specific primer (PCR/SSP) techniques. It was found that the frequencies of HLA-DRB1* 15 and HLA-DRB1* 03 alleles were significantly lower in DCM patients than those in normal controls (14.71% vs 29.71% and 4.41% vs 15.43%, respectively), the relative risks (RR) in the DCM patients being 0.41 and 0.25, respectively, all P < 0.05. However, the frequencies of HLA-DRB1* 11 and HLA-DRB1* 12 alleles were significantly higher in the DCM patients than in controls (29.4% vs 12.00% and 36.76% vs 12.57%, respectively) with the RR in the DCM patients being 3.06 and 4.04, respectively, all P < 0.01. These findings further demonstrated that immunogenetics might play a predominant pathogenetic role in partial DCM patients.
Wang
Q
Q
Department of Cardiology, Institute of Cardiovascular Diseases, Tongji Medical University, Wuhan 430022.
Liao
Y
Y
Gong
F
F
Mao
H
H
Zhang
J
J
D000328:Adult; D000483:Alleles; D002311:Cardiomyopathy, Dilated / Q000235:genetics* / Q000276:immunology; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains