[A case with hepatitis A-associated Guillain-Barre syndrome and elevated serum anti-sulfatide antibody].
A 59-year-old man developed progressive sensory dullness and muscle weakness in the extremities, facial palsy on the left side, and hoarseness 4 days after the onset of acute hepatitis A. Vibration and joint sensation in the extremities were severely affected. Anti-sulfatide IgM antibody level was initially elevated in serum, but diminished along with amelioration of the symptoms following intravenous immunoglobulin therapy. Anti-sulfatide antibody may be involved in the pathogenesis of the present patient with hepatitis A-associated Guillain-Barré syndrome. This is probably the first case of hepatitis A associated Guillain-Barré syndrome with which elevated serum anti-sulfatide antibody was found.
Obara
Daiji
D
Department of Neurology, Iwate Medical University.
Nagane
Yuriko
Y
Utsugisawa
Kimiaki
K
Kondoh
Ryushi
R
Tohgi
Hideo
H
D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D020275:Guillain-Barre Syndrome / Q000209:etiology*; D006506:Hepatitis A / Q000150:complications* / Q000276:immunology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013433:Sulfoglycosphingolipids / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D013433:Sulfoglycosphingolipids; C044203:anti-IgM