title: Synthesis and characterization of a macrocyclic near-infrared optical scaffold.
abstract: Macrocyclization of a bioactive peptide with a bifunctional near-infrared fluorescent optical probe gives a compound that retained the receptor binding affinity of the peptide and the photophysical properties of the optical probe. The robust nature of the new compound provides a structural framework for optimizing the activity of bioactive molecules and for monitoring chemical or biological processes in vivo and in vitro by near-infrared optical methods.
authors.affiliation: Department of Radiology, Washington University, St. Louis, Missouri 63110, USA.
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Ye
authors.forename: Wen Ping
authors.initials: WP
authors.lastname: Li
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Anderson
authors.forename: Jeffery
authors.initials: J
authors.lastname: Kao
authors.forename: Gregory V
authors.initials: GV
authors.lastname: Nikiforovich
authors.forename: Samuel
authors.initials: S
authors.lastname: Achilefu
mesh_terms: D003500:Cyclization; D046911:Macromolecular Substances; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry*; D017481:Receptors, Somatostatin / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared
chemical_list: D046911:Macromolecular Substances; D009842:Oligopeptides; D010456:Peptides, Cyclic; D017481:Receptors, Somatostatin