[The study of the antioxidant enzymes in erythrocytes in lung diseases].
The activity of antioxidative enzymes Cu, Zn-superoxidedismutase (SOD) and catalase as well as content of glutathione and activity of its metabolism enzymes--glutathione reductase (GR) and glutathione peroxidase (GP) were studied in red blood cells of 82 patients: with chronic obstructive pulmonary diseases (COPD, n = 26), chest osteomyelitis (n = 12), malignant (n = 21) and benign (n = 23) pulmonary lesions. Red blood cells from 26 donors served as a control. Enzymes of glutathione and catalase metabolism in the red cells inhibited their activity in all the above pulmonary diseases vs those of the controls: GR activity in COPD and chest osteomyelitis decreased by 40% and more, lung tumors--by 32-36%. GP activity--by 24-27%, 14-19%, respectively. Catalase activity in pulmonary diseases was suppressed by 38-45%. SOD activity in chest osteomyelitis and pulmonary tumors is lower by 37-40% while in COPD is higher by 36%. Activation of SOD in red cells in COPD may be regarded as a compensatory-adaptive response to excessive accumulation of free oxygen radicals in alveoli in COPD.
Matskevich
G N
GN
Korotkina
R N
RN
Devlikanova
A Sh
ASh
Vishnevskiĭ
A A
AA
Karelin
A A
AA
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008171:Lung Diseases / Q000097:blood* / Q000201:enzymology / Q000378:metabolism; D008175:Lung Neoplasms / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000097:blood / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000378:metabolism; D012016:Reference Values; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione