title: The platelet as a model for chemical genetics.
abstract: Chemical genetics is an emerging strategy in chemical biology that promises to bring the power of true genetics to mammalian systems and facilitate the transfer of biological discoveries to therapeutics. The platelet is an anucleate cell with several features that render it suitable for chemical genetic analysis. This review addresses the benefits and challenges of chemical genetics using platelets as a model system.
authors.affiliation: Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. rflaumen@bidmc.harvard.edu
authors.forename: Robert
authors.initials: R
authors.lastname: Flaumenhaft
authors.forename: Derek S
authors.initials: DS
authors.lastname: Sim
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D019204:GTP-Binding Proteins / Q000378:metabolism; D005821:Genetic Techniques; D006657:Histones / Q000378:metabolism; D006801:Humans; D010641:Phenotype; D015539:Platelet Activation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics
chemical_list: D006657:Histones; D010975:Platelet Aggregation Inhibitors; D011505:Protein-Tyrosine Kinases; D019204:GTP-Binding Proteins