An efficient approach to 3,4-disubstituted pyridin-2-ones. Formal synthesis of mappicine ketone.
Treatment of 3,4-dihydro-3-tosylpyridin-2-one 5 with sodium hydride and then alkyl halides gave various 3,4-disubstituted pyridin-2-ones 6. Formal synthesis of mappicine ketone (1) was also reported.
Lin
Ching H
CH
Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China.
Tsai
Min R
MR
Wang
Yung S
YS
Chang
Nein C
NC
D007212:Indolizines / Q000138:chemical synthesis; D010881:Piperidones / Q000737:chemistry; D011728:Pyridones / Q000138:chemical synthesis*; D011804:Quinolines / Q000138:chemical synthesis; D013450:Sulfones / Q000737:chemistry
D007212:Indolizines; D010881:Piperidones; D011728:Pyridones; D011804:Quinolines; D013450:Sulfones; C414097:nothapodytine B; C007864:glutarimide