Can the ischemia-reperfusion syndrome in transplanted kidneys procured from non-heart-beating donors be influenced by adding selenium into the reperfusion solution? An experimental study.
The ischemic-reperfusion syndrome significantly influences the function of a kidney transplanted from a non-heart-beating donor (NHBD). The animal model of a NHBD was used to monitor the influence of exogenous addition of selenium into the reperfusion solution (HTK, Custodiol) with respect to the formation of free oxygen radicals at 0 to 120 minutes after the NHBD transplantation. This maneuvers produced a statistically significant decrease in malondialdehyde concentration, an indicator of free oxygen radicals in the venous blood of the transplanted kidney. The augmentation of the antioxidative capacity of the preservation solution might be a possible route to improve the function of kidneys transplanted from NHBDs.
Treska
V
V
Department of Surgery, University Hospital, Plzen, Czech Republic. treska@fnplzen.cz
Kuntscher
V
V
Molácek
J
J
Kobr
J
J
Racek
J
J
Trefil
L
L
D000818:Animals; D004195:Disease Models, Animal; D005978:Glutathione / Q000097:blood; D006085:Graft Survival / Q000502:physiology; D006323:Heart Arrest; D007668:Kidney; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D019188:Organ Preservation Solutions / Q000494:pharmacology*; D012079:Renal Circulation; D015427:Reperfusion Injury / Q000503:physiopathology* / Q000517:prevention & control; D012643:Selenium / Q000627:therapeutic use*; D013552:Swine; D013997:Time Factors; D014184:Transplantation, Homologous
D019188:Organ Preservation Solutions; D008315:Malondialdehyde; D005978:Glutathione; D012643:Selenium