title: Pharmacokinetic and tumour-photosensitizing properties of methoxyphenyl porphyrin derivative.
abstract: The photokilling activity of 5-[4-N-(2',6'-dinitro-4'-trifluoromethylphenyl) aminophenyl]-10,15,20-tris(2,4,6-trimethoxy phenyl) porphyrin (CF3) was evaluated on a Hep-2 human larynx-carcinoma cell line. An apoptotic mechanism of cell death was found at low irradiation doses. Pharmacokinetic and tumour-photosensitizing properties were studied in mice. The results show that a different mechanism of cell death can be induced depending on the irradiation doses in the photodynamic treatments with CF3, which makes this agent an interesting sensitizer for potential tumour photosensitizer.
authors.affiliation: Departamento de Biología Molecular, Universidad Nacional de Río Cuarto, Agencia Postal No 3, 5800 Río Cuarto, Córdoba, Argentina.
authors.forename: M Gabriela
authors.initials: MG
authors.lastname: Alvarez
authors.forename: Flavia
authors.initials: F
authors.lastname: Morán
authors.forename: E Inés
authors.initials: EI
authors.lastname: Yslas
authors.forename: N Belén Rumie
authors.initials: NB
authors.lastname: Vittar
authors.forename: Mabel
authors.initials: M
authors.lastname: Bertuzzi
authors.forename: Edgardo N
authors.initials: EN
authors.lastname: Durantini
authors.forename: Viviana
authors.initials: V
authors.lastname: Rivarola
mesh_terms: D000818:Animals; D002452:Cell Count; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D006801:Humans; D008081:Liposomes; D051379:Mice; D008807:Mice, Inbred BALB C; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000494:pharmacology*; D010775:Photic Stimulation; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D011166:Porphyrins / Q000493:pharmacokinetics* / Q000494:pharmacology*; D014018:Tissue Distribution
chemical_list: C467708:5-(4-N-(N-2',6'-dinitro-4'-trifluoromethylphenyl)aminophenyl)-10,15,20-tris(2,4,6-trimethoxyphenyl)porphyrin; D008081:Liposomes; D017319:Photosensitizing Agents; D011166:Porphyrins; D010696:Phloroglucinol