title: Histogenesis of hepatoid adenocarcinoma of the stomach: molecular evidence of identical origin with coexistent tubular adenocarcinoma.
abstract: Hepatoid adenocarcinoma of the stomach is a highly malignant neoplasm. Most gastric hepatoid adenocarcinomas coexist with tubular adenocarcinoma. However, the relationship between hepatoid adenocarcinoma and tubular adenocarcinoma is still unclear. In the present study, the characteristics of the coexistent tubular adenocarcinomas were determined by examining their profiles of mucin production. Subsequently, molecular pathological techniques were applied to determine the clonality of 15 mixed hepatoid and tubular adenocarcinomas of the stomach. Mucin analysis suggested that the coexistent tubular adenocarcinomas with hepatoid adenocarcinoma were of the intestinal type. The patterns of chromosome X inactivation were identical between the hepatoid adenocarcinoma component and tubular adenocarcinoma component in all of 3 informative female cases. Mutations in the p53 gene were found in 5 cases. The sequences were identical within both tumor components in all 5 cases. Microsatellite analysis indicated more than 3 common patterns of loss of heterozygosity in 8 cases. These observations strongly suggested that hepatoid adenocarcinomas were of identical origin to coexistent tubular adenocarcinomas.
authors.affiliation: Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan.|Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: Sunao
authors.initials: S
authors.lastname: Akiyama
authors.affiliation: Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: Gen
authors.initials: G
authors.lastname: Tamura
authors.affiliation: Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Endoh
authors.affiliation: Department of Surgery, Prefectural Central Hospital, Yamagata, Japan.
authors.forename: Norimasa
authors.initials: N
authors.lastname: Fukushima
authors.affiliation: Department of Surgery, Prefectural Central Hospital, Yamagata, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Ichihara
authors.affiliation: Department of Surgery, Tsubame Rosai Hospital, Tsubame, Japan.
authors.forename: Kikuo
authors.initials: K
authors.lastname: Aizawa
authors.affiliation: Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: Sumio
authors.initials: S
authors.lastname: Kawata
authors.affiliation: Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: Teiichi
authors.initials: T
authors.lastname: Motoyama
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology*; D041321:Chromosomes, Human, X / Q000235:genetics*; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D016158:Genes, p53 / Q000235:genetics*; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology*; D019656:Loss of Heterozygosity; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D009367:Neoplasm Staging; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm; D009077:Mucins; D000509:alpha-Fetoproteins