Delayed sodium channel inactivation mimics long QT syndrome 3.
DPI 201-106 delays sodium channel inactivation. Acute administration of DPI 201-106 prolonged the QT interval, provoked spontaneous torsades de pointes in one patient, and facilitated stimulation-induced polymorphic ventricular tachyarrhythmias in two patients. Similar to the observations in animal studies, delaying sodium channel inactivation is a new form of the acquired long QT syndrome, mimicking long QT syndrome type 3.
Kühlkamp
Volker
V
Eberhard-Karls-Universität Medizinische Klinik III, Tübingen, Germany. volker.kuehlkamp@med.uni-tuebingen.de
Mewis
Christian
C
Bosch
Ralph
R
Seipel
Ludger
L
D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004562:Electrocardiography; D004594:Electrophysiology; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008133:Long QT Syndrome / Q000209:etiology* / Q000378:metabolism; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects*; D016037:Single-Blind Method; D015222:Sodium Channels / Q000187:drug effects* / Q000502:physiology; D017180:Tachycardia, Ventricular / Q000209:etiology* / Q000378:metabolism
D002316:Cardiotonic Agents; D010879:Piperazines; D015222:Sodium Channels; C046261:DPI 201-106