Synthesis and biological testing of non-fluorinated analogues of levofloxacin.
Quinolones without the usual 6-fluorine substituent have been recently described as potent antibacterial agents. A series of non-fluorinated analogues of the antibacterial quinolone Levofloxacin were synthesized and tested.
Gray
Jeffrey L
JL
Procter & Gamble Pharmaceuticals, 8700Mason-Montgomery Rd, 45040, Mason, OH, USA. gray.jl.2@pg.com
Almstead
Ji In K
JI
Gallagher
Corey P
CP
Hu
X Eric
XE
Kim
Nick K
NK
Taylor
Cynthia J
CJ
Twinem
Tracy L
TL
Wallace
Cynthia D
CD
Ledoussal
Benoit
B
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015242:Ofloxacin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors
D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D059005:Topoisomerase II Inhibitors; D064704:Levofloxacin; D015242:Ofloxacin