Detection and its implication of heat stress protein 27 and P21 in nasopharyngeal carcinoma.
To study the expression of heat stress protein 27 (HSP27) and P21 in nasopharyngeal carcinoma (NPC) tissue, and to evaluate the significance of both HSP27 and P21 in the pathogenesis, development and prognosis of NPC. Indirect immunofluorescence method combined with SABC was applied. Our results showed that (1) the positive rates of HSP27 and P21 expressed in NPC tissue in 36 cases were 88.9% and 94.4%; (2) while in 10 hyperplastic nasopharyngitis tissues, the positive rate of HSP27 and P21 were both 5; (3) all the 5 normal tissues were negatively stained. It is obvious that a co-expressing tendency of HSP27 and P21 could be identified, and it was associated with the degree of malignancy and the clinical stage of NPC. It is concluded that the positive expression of HSP27 and P21 may have clinical significance in the evaluation of the occurring, development and prognosis of NPC, and in NPC treatment.
Liu
L
L
Department of Otolaryngology, Tongji Hospital, Tongji Medical University, Wuhan 430030.
Xiao
C
C
Tao
Y
Y
D000328:Adult; D014408:Biomarkers, Tumor; D006360:Heat-Shock Proteins / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000737:chemistry* / Q000473:pathology; D011379:Prognosis; D016283:Proto-Oncogene Proteins p21(ras) / Q000032:analysis*
D014408:Biomarkers, Tumor; D006360:Heat-Shock Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)