Vitamin B6-mediated suppression of colon tumorigenesis, cell proliferation, and angiogenesis (review).
This review describes current research on the preventive effect of dietary vitamin B(6) against colon tumorigenesis and its possible mechanisms. Studies in cell culture have demonstrated that high levels of vitamin B(6) suppress growth of some cancer cells. From these studies it has been considered that supraphysiological doses of vitamin B(6) suppress tumor growth and metastasis. However, recent rodent study has indicated that azoxymethane-induced colon tumorigenesis in mice is suppressed by moderate doses of dietary vitamin B(6.) Epidemiological studies also support an inverse relationship between vitamin B(6) intake and colon cancer risk. Potential mechanisms underlying the preventive effect of dietary vitamin B(6) have been suggested to include the suppression of cell proliferation, oxidative stress, nitric oxide (NO) synthesis, and angiogenesis.
Matsubara
Kiminori
K
Faculty of Health and Welfare Science, Okayama Prefectual University, Okayama, Japan.
Komatsu
Shun-ichiro
S
Oka
Tatsuzo
T
Kato
Norihisa
N
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D003110:Colonic Neoplasms / Q000517:prevention & control*; D004032:Diet; D006801:Humans; D051379:Mice; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D009569:Nitric Oxide; D018384:Oxidative Stress; D025101:Vitamin B 6 / Q000008:administration & dosage*
D009569:Nitric Oxide; D025101:Vitamin B 6