Structural transition of d(G4T4G4) from antiparallel to parallel G-quartet induced by divalent cations.
We obtained thermodynamic parameters of an antiparallel G-quartet formation of d(G4T4G4) with 1 mM divalent cation (Mg2+, Ca2+, Mn2+, Co2+, or Zn2+). In addition, we also found that a higher concentration of a divalent cation induced a transition from an antiparallel to a parallel G-quartet structure. These results indicate that the divalent cations are a good tool for regulating the G-quartet structures and their stability.
Miyoshi
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D
Department of Chemistry, Faculty of Science and Engineering, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan.
Nakao
A
A
Sugimoto
N
N
D001483:Base Sequence; D002118:Calcium / Q000494:pharmacology; D002413:Cations, Divalent / Q000494:pharmacology; D002942:Circular Dichroism; D003035:Cobalt / Q000494:pharmacology; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D054856:G-Quadruplexes; D006147:Guanine / Q000737:chemistry; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology; D009690:Nucleic Acid Conformation; D013696:Temperature; D013941:Thymine / Q000737:chemistry; D015032:Zinc / Q000494:pharmacology
D002413:Cations, Divalent; D003035:Cobalt; D008345:Manganese; D006147:Guanine; D004247:DNA; D008274:Magnesium; D015032:Zinc; D013941:Thymine; D002118:Calcium