title: Osteogenic and Ewing sarcomas: estimation of necrotic fraction during induction chemotherapy with dynamic contrast-enhanced MR imaging.
abstract: Dynamic contrast material-enhanced magnetic resonance (MR) images of primary osteogenic sarcoma (n = 19) and Ewing sarcoma (n = 10) were reviewed in 29 patients undergoing induction chemotherapy before surgery. Histogram distributions containing the initial slope and pharmacokinetic model parameters from individual voxels within each tumor were fitted for each patient. The histogram analysis of initial slope from the tumor correlated well with percentage necrosis as determined at pathologic examination (r = 0.60, P <.001), as did a two-compartment pharmacokinetic model (r = 0.64, P <.001). Both methods predicted tumors with clinically important degrees of necrosis (ie, > or =90%) in a large majority of cases. The ability to determine response to induction chemotherapy by means of noninvasive monitoring of necrotic fraction with perfusion MR imaging methods may provide useful prognostic information and help surgical planning.
authors.affiliation: Department of Radiology, Weill Medical College of Cornell University, 1300 York Ave, Box 234, New York, NY 10021-4885, USA. jpd2001@med.cornell.edu
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Dyke
authors.forename: David M
authors.initials: DM
authors.lastname: Panicek
authors.forename: John H
authors.initials: JH
authors.lastname: Healey
authors.forename: Paul A
authors.initials: PA
authors.lastname: Meyers
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Huvos
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Schwartz
authors.forename: Howard T
authors.initials: HT
authors.lastname: Thaler
authors.forename: Paul S
authors.initials: PS
authors.lastname: Tofts
authors.forename: Richard
authors.initials: R
authors.lastname: Gorlick
authors.forename: Jason A
authors.initials: JA
authors.lastname: Koutcher
authors.forename: Douglas
authors.initials: D
authors.lastname: Ballon
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003287:Contrast Media; D005260:Female; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis; D012516:Osteosarcoma / Q000188:drug therapy* / Q000473:pathology*; D012512:Sarcoma, Ewing / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D003287:Contrast Media