Effect of calcium carbonate on bioavailability of orally administered gemifloxacin.
We investigated the effect of calcium carbonate on the oral bioavailability of gemifloxacin. Gemifloxacin was administered alone, 2 h before, simultaneously, or 2 h after calcium carbonate in 16 volunteers. Data for 320 mg of gemifloxacin alone were as follows: maximum concentration of drug in serum (C(max)),13 microg/ml; half-life, 7.33 h; and area under the concentration-time curve from 0 h to infinity (AUC( infinity )), 6.79 microg. h/ml. Only simultaneous coadministration of calcium carbonate reduced C(max) (-17%) and AUC( infinity ) (-21%) significantly.
Pletz
M W
MW
Department of Chest and Infectious Diseases, City Hospital E v Behring, Free University of Berlin, Germany.
Petzold
P
P
Allen
A
A
Burkhardt
O
O
Lode
H
H
D000284:Administration, Oral; D000328:Adult; D000863:Antacids / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D002119:Calcium Carbonate / Q000008:administration & dosage*; D018592:Cross-Over Studies; D004347:Drug Interactions; D005260:Female; D024841:Fluoroquinolones; D000077735:Gemifloxacin; D006801:Humans; D008297:Male; D009287:Naphthyridines / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*
D000863:Antacids; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D002119:Calcium Carbonate; D000077735:Gemifloxacin