Linkage analysis suggests a locus of ichthyosis vulgaris on 1q22.
Ichthyosis vulgaris (IV) is an inherited scaling skin disorder with a prevalence estimated at 2.29% in China. The gene responsible for this disorder has not been elucidated. To find the disease gene, we ascertained two Chinese IV families. Linkage analysis identified an IV locus on chromosome 1q22 with a maximum two-point Lod score of 2.47 at D1S1653 (theta=0.00). Haplotype analysis placed the critical region in a 7-cM interval defined by D1S1653 and D1S2675. These results provide the basis for further identifying the gene responsible for IV disorder.
Zhong
Wei
W
Health Science Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 20025 Shanghai, P.R. China.
Cui
Bin
B
Zhang
Yizhi
Y
Jiang
Haisong
H
Wei
Shengcai
S
Bu
Lei
L
Zhao
Guoping
G
Hu
Landian
L
Kong
Xiangyin
X
D002681:China; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D016112:Ichthyosis Vulgaris / Q000235:genetics*; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D010375:Pedigree
D005819:Genetic Markers