title: A facile synthesis of phytosphingosine from diisopropylidene-D-mannofuranose.
abstract: In the present study, an efficient method with a high overall yield for preparing phytosphingosine and an analogue was developed. Starting with commercially available 2,3;5,6-di-O-isopropylidene-d-mannofuranose, a variety of lipid moieties were incorporated to obtain phytosphingosine and an analogue. Through an eight-step manipulation, phytosphingosine was obtained with an overall yield of 57%.
authors.affiliation: Institute of Chemistry, Academia Sinica, Nankang, Taipei 115, Taiwan.
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Chiu
authors.forename: Der-Lii M
authors.initials: DL
authors.lastname: Tzou
authors.forename: Laxmikant Narhari
authors.initials: LN
authors.lastname: Patkar
authors.forename: Chun-Cheng
authors.initials: CC
authors.lastname: Lin
mesh_terms: D008055:Lipids / Q000737:chemistry; D008358:Mannose / Q000737:chemistry; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: D008055:Lipids; C012491:phytosphingosine; D013110:Sphingosine; D008358:Mannose