Association of vitamin D receptor gene polymorphism with periodontal diseases in Japanese and Chinese.
We examined whether polymorphisms in the vitamin D receptor (VDR) gene are associated with the incidence of adult periodontitis (AP) and early-onset periodontitis (EOP) in case-controlled studies of Japanese and Chinese subjects. Restriction fragment length polymorphisms in the VDR gene detected by digestion with Taq I were found to be significantly associated with the occurrence of AP or EOP, suggesting that the VDR genotype a risk factor for periodontitis.
Tachi
Y
Y
Department of Pharmacology, Osaka Dental University.
Shimpuku
H
H
Nosaka
Y
Y
Kawamura
T
T
Shinohara
M
M
Ueda
M
M
Imai
H
H
Ohura
K
K
Sun
J
J
Meng
H
H
Cao
C
C
D000328:Adult; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000235:genetics*; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*
D018167:Receptors, Calcitriol