Ruthenium(III) triazacyclononane dithiocarbamate, pyridinecarboxylate, or aminocarboxylate complexes as scavengers of nitric oxide.
The preparation of a series of [Ru(III)(tacn)(eta(2)-dtc)(eta(1)-dtc)][PF(6)] (tacn = 1,4,7-triazacyclononane; dtc = dimethyldithiocarbamate, diethyldithiocarbamate, pyrrolidinedithiocarbamate, l-prolinedithiocarbamate, l-prolinemethyl ester dithiocarbamate, l-N-methylisoleucinedithiocarbamate) complexes, 5-11, is described. Complex 5 reacts with NO to form the ruthenium nitrosyl complex 12. A series of [Ru(III)(tacn)(pyc)Cl][PF(6)] (pyc = 2-pyridinecarboxylic acid, 2,4- and 2,6-pyridinecarboxylic acid) complexes, 14-16, were prepared along with [Ru(III)(tacn)(mida)][PF(6)] (mida = N-methyliminodiacetic acid), 13, and [Ru(III)(Hnota)Cl], 17, (Hnota = 1-acetic acid-4,7-bismethylcarboxylate-1,4,7-triazacyclononane). Complexes 5-17 were evaluated for use as NO scavengers in an in vitro assay using RAW264 murine macrophage cells. [Ru(III)(tacn)(eta(2)-dtc)(eta(1)-dtc)][PF(6)] complexes 5-11 are very efficient NO scavengers in this assay.
Cameron
Beth R
BR
AnorMED Inc., 200-20353 64th Avenue, Langley, British Columbia, Canada V2Y 1N5. bcameron@anormed.com
Darkes
Marilyn C
MC
Baird
Ian R
IR
Skerlj
Renato T
RT
Santucci
Zefferino L
ZL
Fricker
Simon P
SP
D000818:Animals; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D007202:Indicators and Reagents; D008024:Ligands; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009569:Nitric Oxide / Q000737:chemistry* / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry*; D010848:Picolinic Acids / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013859:Thiocarbamates / Q000737:chemistry*
D006573:Heterocyclic Compounds, 1-Ring; D007202:Indicators and Reagents; D008024:Ligands; D009942:Organometallic Compounds; D010848:Picolinic Acids; D013859:Thiocarbamates; D009569:Nitric Oxide; D012428:Ruthenium