title: Macular pigment density and distribution: comparison of fundus autofluorescence with minimum motion photometry.
abstract: Macular pigment (MP) distribution profiles were measured for 18 subjects using a Moreland anomaloscope modified for motion photometry. The total amount of MP within the central 7 degrees was estimated from the distribution profile by numerical integration. Fundus autofluorescence images were obtained for eight of these subjects using a scanning laser ophthalmoscope. Peak optical density of MP increased with the total amount present, but the correlation was weakened by inter-subject differences in MP distribution. The mean MP distribution derived from mean grey-scale profiles of fundus autofluorescence images correlated closely with that obtained psychophysically (r=0.96). Autofluorescence imaging provides a fast non-invasive method for assessing MP in vivo.
authors.affiliation: Moorfields Eye Hospital, City Road, London EC1V 2PD, UK.
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Robson
authors.forename: Jack D
authors.initials: JD
authors.lastname: Moreland
authors.forename: Daniel
authors.initials: D
authors.lastname: Pauleikhoff
authors.forename: Tony
authors.initials: T
authors.lastname: Morrissey
authors.forename: Graham E
authors.initials: GE
authors.lastname: Holder
authors.forename: Fred W
authors.initials: FW
authors.lastname: Fitzke
authors.forename: Alan C
authors.initials: AC
authors.lastname: Bird
authors.forename: Frederik J G M
authors.initials: FJ
authors.lastname: van Kuijk
mesh_terms: D000375:Aging / Q000502:physiology; D005453:Fluorescence; D006801:Humans; D008266:Macula Lutea / Q000378:metabolism; D008268:Macular Degeneration / Q000209:etiology*; D009039:Motion Perception / Q000502:physiology; D019721:Ophthalmoscopes; D010783:Photometry / Q000379:methods; D012160:Retina / Q000502:physiology*; D012168:Retinal Pigments / Q000378:metabolism
chemical_list: D012168:Retinal Pigments