title: Selection of resistance mutations in pregnant women receiving zidovudine and lamivudine to prevent HIV perinatal transmission.
abstract: Two zidovudine/lamivudine regimens for the prevention of HIV perinatal transmission were studied for the selection of resistance mutations. The M184V mutation was detected one week after delivery in six out of fifty women (12%) who received the regimen prepartum, intrapartum and postpartum, and was no longer present 3 months later. No nucleoside reverse transcriptase inhibitor resistance-associated mutations were detected in 50 women who received zidovudine/lamivudine intrapartum and postpartum only. No association with the risk of perinatal transmission was found.
authors.affiliation: Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Giuliano
authors.forename: Lucia
authors.initials: L
authors.lastname: Palmisano
authors.forename: Clementina M
authors.initials: CM
authors.lastname: Galluzzo
authors.forename: Roberta
authors.initials: R
authors.lastname: Amici
authors.forename: Elena
authors.initials: E
authors.lastname: Germinario
authors.forename: Pius
authors.initials: P
authors.lastname: Okong
authors.forename: Praxedes
authors.initials: P
authors.lastname: Kituuka
authors.forename: Francis
authors.initials: F
authors.lastname: Mmirro
authors.forename: Michele
authors.initials: M
authors.lastname: Magoni
authors.forename: Stefano
authors.initials: S
authors.lastname: Vella
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D019259:Lamivudine / Q000627:therapeutic use*; D009154:Mutation; D011247:Pregnancy; D012189:Retrospective Studies; D015215:Zidovudine / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D019259:Lamivudine; D015215:Zidovudine