title: The QSAR analysis of tricyclic non-nucleoside inhibitors of HIV-1 reverse transcriptase.
abstract: The inhibitory activities against HIV-1 RT of 44 tricyclic oxazepinones (from ref. 8, 9, 12) and 76 tricyclic diazepinones (from ref. 10, 11) have been correlated with 15 physicochemical parameters. The physicochemical parameters and 3D models of investigated compounds were obtained with the HyperChem program. A correlation between biological activity data (from ref. 8-12) and physicochemical data of the examined compounds was investigated by the regression analysis method with the STATISTICA program.
authors.affiliation: Department of Analytical Chemistry, Medical University of Lódź, 1 Muszyńskiego Str., 90-151 Lódź, Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Brzezińska
mesh_terms: D000465:Algorithms; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D015195:Drug Design; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D006801:Humans; D021281:Quantitative Structure-Activity Relationship; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase