Lactate levels in children with HIV/AIDS on highly active antiretroviral therapy.
A total of 251 venous lactate levels were obtained from 127 children with HIV/AIDS; 104 on highly active antiretroviral therapy, and 23 not on therapy. Asymptomatic hyperlactatemia (> 2 mmol/l) was found in 41 children; no hepatic dysfunction or life-threatening lactic acidosis occurred. Asymptomatic hyperlactatemia is associated with treatment with nucleoside reverse transcriptase inhibitors or protease inhibitors and with undetectable viral loads regardless of treatment regimen, suggesting that elevated lactate levels are useful in evaluating adherence.
Desai
Ninad
N
Children's Hospital, SUNY Downstate Medical Center, Brooklyn Pediatric AIDS Network, Brooklyn, NY, USA.
Mathur
Mudit
M
Weedon
Jeremy
J
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000188:drug therapy* / Q000276:immunology; D000293:Adolescent; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D010349:Patient Compliance; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D019438:Ritonavir / Q000627:therapeutic use; D018119:Stavudine / Q000627:therapeutic use; D019562:Viral Load
D019380:Anti-HIV Agents; D015415:Biomarkers; D017320:HIV Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors; D019344:Lactic Acid; D018119:Stavudine; D019438:Ritonavir