Effects on M5076-hepatic metastasis of retinoic acid and N-(4-hydroxyphenyl) retinamide, fenretinide entrapped in SG-liposomes.
Retinoic acid (RA), a potent inducer of cell differentiation, and N-(4-hydroxyphenyl)retinamide (4-HPR, fenretinide), a potent inducer of apoptosis, are well known as anticancer agents that are administered orally to patients for leukemia, breast and prostate cancer, respectively. However, it has not been studied whether both retinoids are effective on metastatic cancer. In mice implanted with M5076 cells, murine reticulum cell sarcoma survival times were prolonged by i.v. treatment of RA and 4-HPR entrapped in liposomes containing soybean-derived sterylglucoside mixture (SG), which accumulates in liver. In contrast, free RA and 4-HPR were inactive. These results indicate that RA and 4-HPR in SG-liposomes exhibit anticancer efficacy on metastatic cancers, and may have great potential for clinical use in the treatment of various cancers.
Takahashi
Noriko
N
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. t-noriko@hoshi.ac.jp
Tamagawa
Kayoko
K
Shimizu
Kazuyuki
K
Fukui
Tetsuya
T
Maitani
Yoshie
Y
D000818:Animals; D045744:Cell Line, Tumor; D002782:Cholestenes / Q000008:administration & dosage* / Q000737:chemistry; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D017313:Fenretinide / Q000008:administration & dosage* / Q000737:chemistry; D008081:Liposomes; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D014212:Tretinoin / Q000008:administration & dosage* / Q000737:chemistry; D023041:Xenograft Model Antitumor Assays / Q000379:methods
D002782:Cholestenes; D008081:Liposomes; C096056:soy derived sterylglucoside mixture; D017313:Fenretinide; D014212:Tretinoin