title: Steroidogenic acute regulatory protein expression in the normal human brain and intracranial tumors.
abstract: In this study we found the expression of steroidogenic acute regulatory protein (StAR) mRNA and protein in both the normal human brain and intracranial tumors, using RT-PCR and immunohistochemistry. StAR mRNA is expressed at a very low level in the white matter of the normal human brain, but in tumoral tissues StAR mRNA was specifically expressed in oligodendrogliomas and malignant glial tumors. StAR-positive cells were also detected in the normal human brains and gliomas; its frequency and density were higher in glioma tissue. These findings suggest that StAR expression might be correlated with the growth of glial tumors.
authors.affiliation: Department of Anatomy, Institute of Health Science, College of Medicine, Gyeongsang National University, 92 Chilam-dong, Jinju 660-751, South Korea.
authors.forename: Hyun Joon
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Myung
authors.initials: M
authors.lastname: Ha
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Jong Tae
authors.initials: JT
authors.lastname: Kim
authors.forename: In Sung
authors.initials: IS
authors.lastname: Park
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Paek
authors.forename: Hee-Won
authors.initials: HW
authors.lastname: Jung
authors.forename: Dong Gyu
authors.initials: DG
authors.lastname: Kim
authors.forename: Gyeong Jae
authors.initials: GJ
authors.lastname: Cho
authors.forename: Wan Sung
authors.initials: WS
authors.lastname: Choi
mesh_terms: D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005910:Glioma / Q000145:classification / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D000098682:Steroidogenic Acute Regulatory Protein
chemical_list: D005904:Glial Fibrillary Acidic Protein; D010750:Phosphoproteins; D012333:RNA, Messenger; D000098682:Steroidogenic Acute Regulatory Protein