Nitric oxide-releasing mesalamine: potential utility for treatment of inflammatory bowel disease.
Nitric oxide can accelerate ulcer healing and exert anti-inflammatory effects. Addition of a nitric oxide-releasing moiety to mesalamine significantly boosts its anti-inflammatory activity. NO-releasing mesalamine suppresses inflammatory cytokine production and reduces leukocyte infiltration.
Wallace
J L
JL
Mucosal Inflammation Research Group, University of Calgary, Calgary, Alberta T2N 4N1, Canada. wallacej@ucalgary.ca
D000636:Aminosalicylic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D003092:Colitis / Q000188:drug therapy*; D016207:Cytokines / Q000096:biosynthesis; D004195:Disease Models, Animal; D006801:Humans; D007962:Leukocytes / Q000187:drug effects; D019804:Mesalamine / Q000494:pharmacology / Q000627:therapeutic use*; D009288:Naproxen / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats
D000636:Aminosalicylic Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; C434799:NO-mesalamine; C111751:naproxen-n-butyl nitrate; D009569:Nitric Oxide; D019804:Mesalamine; D009288:Naproxen