title: [Treatment of second primary malignant tumor induced by radiotherapy].
abstract: OBJECTIVE
  To study the diagnosis and treatment of a second primary malignant tumor induced by previous radiotherapy.
  
  
  METHODS
  From March 1970 to March 1997, 108 nasopharyngeal cancer (NPC) patients who developed a second primary malignant tumor induced by radiotherapy were treated. There were squamous carcinoma 43 (39.8%), sarcoma 26 (24.1%), malignant fibrous histiocytoma 14 (13.0%), adenoid cystic carcinoma 12 (11.1%), thyroid papillary adenocarcinoma 8 (7.4%) and malignant melanoma 5 (4.6%). Fifty patients underwent operation, 32 received radiotherapy, 18 received chemotherapy and 8 received operation combined with chemotherapy.
  
  
  RESULTS
  The 3- and 5-year tumor-free survival rates were 64.0% and 36.0% in the operation group. They were 34.4% and 18.8% in the radiotherapy group.
  
  
  CONCLUSIONS
  Surgery, if not contra-indicated, is the first choice for the second primary malignant tumor induced by radiotherapy. Aggressive treatment for these patients is, hence, indicated clinically.
authors.affiliation: Department of Head and Neck, Tumor Hospital, Sun Yat-sen University, Guangzhou 510060, China.
authors.forename: Guo-hao
authors.initials: GH
authors.lastname: Wu
authors.forename: Fu-jin
authors.initials: FJ
authors.lastname: Chen
authors.forename: Zong-yuan
authors.initials: ZY
authors.lastname: Zeng
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Guo-wu
authors.initials: GW
authors.lastname: Lin
authors.forename: Ming
authors.initials: M
authors.lastname: Song
authors.forename: Mao-wen
authors.initials: MW
authors.lastname: Wei
authors.forename: Guang-pu
authors.initials: GP
authors.lastname: Xu
authors.forename: An-kui
authors.initials: AK
authors.lastname: Yang
authors.forename: Wen-kuan
authors.initials: WK
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects*; D015996:Survival Rate