title: A model to predict severe HCV-related disease following liver transplantation.
abstract: Post-transplantation recurrence is increasing in patients with HCV. Early antiviral therapy may be of benefit in this setting. Thus, accurate and early prediction of progression may help select candidates for treatment. We developed a model based on pre- and/or early post-transplantation variables, which may predict progression to severe disease. Clinical and histologic outcomes were assessed in 554 liver recipients. A total of 1,353 biopsy specimens obtained after 1 year (median of 2 biopsies per patient; range, 1-8) were scored. Two outcome measures were used: cumulative probability of developing severe disease (fibrosis 3 and 4) within 5 years and actual progression to severe disease in 2 years. We used Cox proportional hazard survival analysis for the whole cohort. Predictors analyzed included HCV genotype and recipient, donor, and transplant-related variables. The cumulative risk of progressing to fibrosis 3 and 4 was significantly greater in patients transplanted recently (P <.001) and was present in all centers. Factors increasing this risk were genotype, induction with mycophenolate, donor age, short course of azathioprine, and prednisone (<12 months). To create a model of prediction, 285 patients with 2-year follow-up were used to create a logistic regression analysis. The estimated probability of being at high risk for severe disease was calculated from a formula that included donor age and recipient therapy as critical variables. In conclusion, we have developed a model that uses early post-transplantation variables to predict severe HCV recurrence. Accuracy of the model is not perfect (c-statistic 0.80), probably reflecting the complexity of HCV in the liver transplant setting.
authors.affiliation: Hepato-Gastroenterology Service, Pathology Service, Hospital Universitario La FE, Valencia, Spain. mbhaym@teleline.es
authors.forename: Marina
authors.initials: M
authors.lastname: Berenguer
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Crippin
authors.forename: Robert
authors.initials: R
authors.lastname: Gish
authors.forename: Nathan
authors.initials: N
authors.lastname: Bass
authors.forename: Alan
authors.initials: A
authors.lastname: Bostrom
authors.forename: George
authors.initials: G
authors.lastname: Netto
authors.forename: Judy
authors.initials: J
authors.lastname: Alonzo
authors.forename: Richard
authors.initials: R
authors.lastname: Garcia-Kennedy
authors.forename: Jose-Miguel
authors.initials: JM
authors.lastname: Rayón
authors.forename: Teresa L
authors.initials: TL
authors.lastname: Wright
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000175:diagnosis* / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D016031:Liver Transplantation / Q000401:mortality*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012307:Risk Factors; D012720:Severity of Illness Index