title: The molecular mechanisms by which nitric oxide controls mitochondrial complex IV.
abstract: This mini-review of focussed on the information available on the molecular mechanisms by which NO controls the function of mitochondrial cytochrome c oxidase and thereby cell respiration. The reaction mechanisms are described as dissected in vitro and recently confirmed in cell cultures, whereby two reaction pathways have been identified, leading to accumulation of either the [a3(2+)NO]-nitrosyl or the [a3(3+)NO2-]-nitrite derivative of the enzyme. The experimental data and the theoretical computation analysis, supporting the hypothesis that one pathway prevails on the other depending on the electron flow level through the respiratory chain, are discussed. Finally, the patho-physiological implications of the reaction between NO and CcOX have been also outlined.
authors.affiliation: Department of Biochemical Sciences, University of Rome La Sapienza, I-00185 Rome, Italy. paolo.sarti@uniroma1.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Sarti
authors.forename: Marzia
authors.initials: M
authors.lastname: Arese
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giuffrè
mesh_terms: D000818:Animals; D004579:Electron Transport; D003576:Electron Transport Complex IV / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008928:Mitochondria / Q000201:enzymology*; D008954:Models, Biological; D009569:Nitric Oxide / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D013997:Time Factors
chemical_list: D009569:Nitric Oxide; D003576:Electron Transport Complex IV; D010100:Oxygen