Simultaneous detection of some drugs of abuse in saliva samples by SPME technique.
A simple method for the simultaneous determination of many drugs of abuse in saliva is referred [methadone, 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium perchlorate (EDDP), cocaine, cocaethylene, amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyethyl amphetamine (MDEA), N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB), cannabidiol (CBD), Delta(9)-tetrahydrocannabinol (THC), cannabinol (CBN)]. Head space-solid phase microextraction (HS-SPME) and direct immersion-solid phase microextraction (DI-SPME) followed by gas chromatographic/mass spectrometric analyses (GC/MS) were employed, and results obtained with both techniques are discussed. The method was validated testing reproducibility, sensitivity, linearity.
Fucci
Nadia
N
Laboratorio di Tossicologia Forense, Istituto di Medicina Legale e delle Assicurazioni, Università Cattolica del Sacro Cuore, L. go Francesco Vito, 00168-Rome, Italy. fortox@rm.unicatt.it
De Giovanni
Nadia
N
Chiarotti
Marcello
M
D005554:Forensic Medicine / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D009294:Narcotics / Q000032:analysis*; D015203:Reproducibility of Results; D012463:Saliva / Q000737:chemistry*; D012680:Sensitivity and Specificity
D009294:Narcotics