title: The relation of QT dispersion and localized QT difference to coronary pathology in a population with unstable coronary artery disease.
abstract: BACKGROUND
  QT dispersion (QTd) contains prognostic information in several patient groups. The variable increases in several conditions with ischemia. Originally, it was thought to reflect the local repolarization inhomogeneity. Even though this explanation has been questioned lately, it continues to be put forward. In order to elucidate a possible local mechanism, we investigated the relation between QT dispersion, an ECG parameter reflecting the local dispersion, and angiographical measures in a population with unstable coronary artery disease.
  
  
  METHODS
  The 276 patients were recruited from the FRISC II trial. As the QTd parameter we used the mean value of automatically measured QTd during 27 hours after admission (QTdMean). As a local repolarization measure we used the maximal difference in QT between two adjacent ECG leads (QTdiffMean). The computations were performed on all available ECG leads and on a restricted set without the V1-V2 combination. Previously published angiographic scoring tools were adapted for rating and localizing the coronary pathology by two approaches and applied on 174 patients undergoing angiography.
  
  
  RESULTS
  QTdMean was significantly higher than that reported in previous material with unselected chest pain patients (55 vs 40 ms). QTdiffMean correlated strongly with QTdMean. No differences in QTdMean were detected between patients with different angiographical scores. No relation could be shown between the region with dominating coronary pathology as expressed by the scoring tools and the localization of QTdiffMean.
  
  
  CONCLUSIONS
  QTd in ischemia seems to be increased by a mechanism unrelated to localization and severity of coronary disease.
authors.affiliation: Department of Cardiology, Norrland University Hospital, 90185 Umea, Sweden. milos.kesek@zeta.telenordia.se
authors.forename: Milos
authors.initials: M
authors.lastname: Kesek
authors.forename: Anders
authors.initials: A
authors.lastname: Englund
authors.forename: Tomas
authors.initials: T
authors.lastname: Jernberg
authors.forename: Bo
authors.initials: B
authors.lastname: Lagerqvist
authors.forename: Bertil
authors.initials: B
authors.lastname: Lindahl
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000503:physiopathology*; D017023:Coronary Angiography; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000503:physiopathology*; D011446:Prospective Studies; D012307:Risk Factors; D013577:Syndrome