Function and regulation of Ena/VASP proteins.
Regulation of cytoskeletal dynamics is required to coordinate cell movement, adhesion and shape change. The Ena/VASP protein family is thought to play an important role in linking signaling pathways to remodeling of the actin cytoskeleton. This review will examine the mechanisms by which Ena/VASP function might control actin dynamics and how these proteins are linked to various signaling pathways.
Kwiatkowski
Adam V
AV
Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Gertler
Frank B
FB
Loureiro
Joseph J
JJ
D008841:Actin Cytoskeleton / Q000378:metabolism*; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology*; D048429:Cell Size / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008840:Microfilament Proteins; D010750:Phosphoproteins / Q000378:metabolism*; D011554:Pseudopodia / Q000378:metabolism / Q000648:ultrastructure; D000098662:Vasodilator-Stimulated Phosphoprotein
D015815:Cell Adhesion Molecules; D004268:DNA-Binding Proteins; C092744:ENA-VASP proteins; D008840:Microfilament Proteins; D010750:Phosphoproteins; D000098662:Vasodilator-Stimulated Phosphoprotein