title: Antimycobacterial activity of 1-substituted indolizines.
abstract: Indolizine derivatives were tested as antimycobacterials against Mycobacterium tuberculosis H(37)Rv (ATCC 27294)in BACTEC 12B medium using the Microplate Alamar Blue Assay. The most active compounds examined carry an alpha-hydroxybenzyl substituent in the indolizine 1-position. MICs against Mycobacterium tuberculosis for these compounds were 6.25 microg/mL
authors.affiliation: Department of Chemistry, University of Oslo, Blindern, Norway. l.l.gundersen@kjemi.uio.no
authors.forename: Lise-Lotte
authors.initials: LL
authors.lastname: Gundersen
authors.forename: Ayele H
authors.initials: AH
authors.lastname: Negussie
authors.forename: Frode
authors.initials: F
authors.lastname: Rise
authors.forename: Ole Benny
authors.initials: OB
authors.lastname: ØStby
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D007212:Indolizines