title: At the crossroads of chemistry and biology.
abstract: The life sciences are molecular and the harnessing of information gleaned from genomics and proteomics will require interdisciplinary research integrating chemistry and biology. This approach is illustrated by the synthesis and biological evaluation of lipidated peptides and proteins and the delineation of a concept arguing for natural product guided combinatorial chemistry.
authors.affiliation: Max-Planck-Institut für molekulare Physiologie, Abt. Chemische Biologie, Otto-Hahn-Str. 11, D-44227 Dortmund, Germany. herbert.waldmann@mpi-dortmund.mpg.de
authors.forename: H
authors.initials: H
authors.lastname: Waldmann
mesh_terms: D001671:Biochemistry / Q000639:trends*; D001690:Biological Science Disciplines / Q000639:trends*; D001695:Biology / Q000639:trends*; D020650:Combinatorial Chemistry Techniques; D023281:Genomics / Q000379:methods; D008074:Lipoproteins / Q000138:chemical synthesis / Q000378:metabolism; D008956:Models, Chemical; D010455:Peptides / Q000138:chemical synthesis / Q000378:metabolism; D040901:Proteomics / Q000379:methods; D042787:Receptor, TIE-2 / Q000037:antagonists & inhibitors / Q000737:chemistry; D040321:Vascular Endothelial Growth Factor Receptor-3 / Q000037:antagonists & inhibitors / Q000737:chemistry; D020691:rab GTP-Binding Proteins / Q000138:chemical synthesis / Q000378:metabolism; D018631:ras Proteins / Q000138:chemical synthesis / Q000378:metabolism
chemical_list: D008074:Lipoproteins; D010455:Peptides; D042787:Receptor, TIE-2; D040321:Vascular Endothelial Growth Factor Receptor-3; D020691:rab GTP-Binding Proteins; D018631:ras Proteins