title: Rotavirus diarrhea severity is related to the VP4 type in Mexican children.
abstract: This report is of a community-based case control study to assess whether the severity of acute diarrhea by rotavirus (RV) in young children is associated with a particular VP7 (G) or VP4 (P) RV serotype. Five hundred twenty children younger than 2 years of age with diarrhea lasting less than 3 days were age and gender matched with 520 children with no diarrhea. The G and P serotypes were determined with specific monoclonal antibodies, and the VP4 serotype specificity in a subgroup was confirmed by genotyping. Infection with a G3 serotype led to a higher risk of diarrhea than infection with a G1 serotype. Infection with a G3-nontypeable-P serotype was associated with more severe gastroenteritis than infection with a G3 (or G1) P1A[8] serotype. A child with diarrhea-associated dehydration was almost five times more likely to be infected with a G3-nontypeable-P serotype than a child without dehydration (P < 0.001). Moreover, the two predominant monotypes within serotype P1A[8] had significantly different clinical manifestations. In this study, the severity of RV-associated diarrhea was related to different P serotypes rather than to G serotypes. The relationship between serotype and clinical outcomes seems to be complex and to vary among different geographic areas.
authors.affiliation: Departamento de Medicina Comunitaria e Hidratación Oral, Hospital Infantil de México Federico Gómez, Mexico City, Mexico. fmota@mail.ssa.gov.mx
authors.forename: Felipe
authors.initials: F
authors.lastname: Mota-Hernández
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Calva
authors.forename: Claudia
authors.initials: C
authors.lastname: Gutiérrez-Camacho
authors.forename: Sofía
authors.initials: S
authors.lastname: Villa-Contreras
authors.forename: Carlos F
authors.initials: CF
authors.lastname: Arias
authors.forename: Luis
authors.initials: L
authors.lastname: Padilla-Noriega
authors.forename: Héctor
authors.initials: H
authors.lastname: Guiscafré-Gallardo
authors.forename: María
authors.initials: M
authors.lastname: de Lourdes Guerrero
authors.forename: Susana
authors.initials: S
authors.lastname: López
authors.forename: Onofre
authors.initials: O
authors.lastname: Muñoz
authors.forename: Juan F
authors.initials: JF
authors.lastname: Contreras
authors.forename: Roberto
authors.initials: R
authors.lastname: Cedillo
authors.forename: Ismael
authors.initials: I
authors.lastname: Herrera
authors.forename: Fernando I
authors.initials: FI
authors.lastname: Puerto
mesh_terms: D000956:Antigens, Viral; D036022:Capsid Proteins / Q000235:genetics*; D016022:Case-Control Studies; D002675:Child, Preschool; D003967:Diarrhea / Q000503:physiopathology* / Q000821:virology; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008800:Mexico; D012401:Rotavirus / Q000145:classification* / Q000235:genetics / Q000472:pathogenicity*; D012400:Rotavirus Infections / Q000503:physiopathology / Q000821:virology; D012703:Serotyping; D012720:Severity of Illness Index
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; C060339:VP4 protein, Rotavirus; C050779:VP7 protein, Rotavirus