Scleroderma renal crisis.
Renal crisis occurs in patients who have systemic sclerosis with rapidly progressive diffuse cutaneous thickening early in their disease. SRC is characterized by malignant hypertension, hyperreninemia, azotemia, microangiopathic hemolytic anemia, and renal failure. SRC was almost uniformly fatal, but in most cases it can now be successfully treated with ACE inhibitors. This therapy has improved survival, reduced the requirement for dialysis, and often allowed for the discontinuation of dialysis 6 to 18 months later. Prompt diagnosis and early, aggressive initiation of therapy with ACE inhibitors will result in the most optimal outcome.
Steen
Virginia D
VD
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Georgetown University, 3800 Reservoir Road, NW-LL Gorman, Washington, DC 20007, USA. steenv@georgetown.edu
D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D012595:Scleroderma, Systemic / Q000150:complications* / Q000473:pathology / Q000628:therapy; D016896:Treatment Outcome