title: Callyspongamide A, a new cytotoxic polyacetylenic amide from the Red Sea sponge Callyspongia fistularis.
abstract: Callyspongamide A (1), a new cytotoxic polyacetylenic amide, has been isolated from the marine sponge Callyspongia fistularis collected in the Red Sea. Callyspongamide A is an amide derivative of a C(17)-polyacetylenic acid and phenethylamine. It represents a new class of secondary metabolites within the family Callyspongiidae. Its structure was determined on the basis of 1D and 2D (COSY, HOHAHA, HMQC, and HMBC) NMR studies and high-resolution mass spectral measurement.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
authors.forename: Diaa T A
authors.initials: DT
authors.lastname: Youssef
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fusetani
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000480:Alkynes; D000577:Amides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D019156:Indian Ocean; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011108:Polymers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000480:Alkynes; D000577:Amides; D000970:Antineoplastic Agents; D011108:Polymers; C478730:callyspongamide A; D000114:Acetylene