title: Neurotoxicity of some MAO inhibitors in adult rat hypothalamic cell culture.
abstract: Monoamine oxidase-A (MAO-A) [amiflamine (AMF) and 4-methylthioamphetamine (MTA)] and MAO-B (L-deprenyl) inhibitors were found to be cytotoxic in a concentration-dependent manner for RCHT cells derived from adult rat hypothalamus. The cytotoxic effects were increased when the inhibitors were co-incubated with dicoumarol and especially with 25 micro M AMF+100 micro M dicoumarol (2.5-fold; P <0.001). The treatment of RCHT cells solely with AMF induced a marked decrease in the expression of DT-diaphorase mRNA.
authors.affiliation: Department of Chemistry, Faculty of Sciences, Millennium Institute for Cell Biology and Biotechnology, University of Chile, Santiago, Chile. jsegura@machi.med.uchile.cl
authors.forename: C
authors.initials: C
authors.lastname: Hurtado-Guzmán
authors.forename: P
authors.initials: P
authors.lastname: Martínez-Alvarado
authors.forename: A
authors.initials: A
authors.lastname: Dagnino-Subiabre
authors.forename: I
authors.initials: I
authors.lastname: Paris
authors.forename: P
authors.initials: P
authors.lastname: Caviedes
authors.forename: R
authors.initials: R
authors.lastname: Caviedes
authors.forename: B K
authors.initials: BK
authors.lastname: Cassels
authors.forename: J
authors.initials: J
authors.lastname: Segura-Aguilar