DVT: Factor V Leiden, a case report.
We report a case of a 33-year old male admitted to our hospital with extensive lower extremity deep venous thrombosis (DVT). This patient was several days post knee arthroscopy and had a family history strongly positive for DVT. Upon testing, he was found positive for the homozygous presence of Factor V gene R506Q mutation. In inherited thrombophillia, especially in homozygous Factor V Leiden, lifelong anticoagulation treatment and screening for asymptomatic family members is controversial. Upon review and consultation, however, we recommended oral anticoagulation for life, along with genetic counseling and screening for Factor V Leiden of his three children and younger brother.
Birewar
Sonali
S
USD School of Medicine, Sioux Falls, SD, USA. sbirewar@usd.edu
Thomas
Melvin
M
McHale
Michael S
MS
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001182:Arthroscopy / Q000009:adverse effects; D005165:Factor V / Q000235:genetics*; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007717:Knee / Q000601:surgery; D008297:Male; D011183:Postoperative Complications; D016896:Treatment Outcome; D014463:Ultrasonography; D020246:Venous Thrombosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D014859:Warfarin / Q000627:therapeutic use
D000925:Anticoagulants; C095381:factor V Leiden; D014859:Warfarin; D005165:Factor V; D006493:Heparin