[Hypogammaglobulinemia associated with thymoma (Good syndrome) similar to diffuse panbronchiolitis].
A 65-year-old woman complained of dyspnea and a productive cough after surgical treatment and irradiation therapy for thymoma. Chest radiography and high-resolution computed tomography showed small nodules in centrilobular lesions in all of both lung fields, but predominantly in the lower fields. In addition, blood tests showed hypogammaglobulinemia. Chronic sinusitis, mild hypoxemia, severe obstructive impairment and the pathological findings of bronchiolitis led to a diagnosis of sinobronchial syndrome caused by Good syndrome. Treatment with oral erythromycin 600 mg/day was started. After 6 months, the patient improved both clinically and radiologically. Low-dose, long-term treatment with erythromycin was effective against sinobronchial syndrome caused by Good syndrome.
Tsuburai
Takahiro
T
First Department of Internal Medicine, Yokohama City University School of Medicine.
Ikehara
Kunihiko
K
Suzuki
Shunsuke
S
Shinohara
Takeshi
T
Mishima
Wataru
W
Tagawa
Akihiro
A
Itou
Masaru
M
Miyazawa
Naoki
N
Nishiyama
Harumi
H
Shoji
Akira
A
Suzuki
Motoyoshi
M
Matsuse
Takeshi
T
Ishigatsubo
Yoshiaki
Y
D000361:Agammaglobulinemia / Q000150:complications*; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001988:Bronchiolitis / Q000188:drug therapy* / Q000209:etiology; D004917:Erythromycin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D012852:Sinusitis / Q000150:complications / Q000188:drug therapy; D013577:Syndrome; D013945:Thymoma / Q000150:complications*; D013953:Thymus Neoplasms / Q000150:complications*
D000900:Anti-Bacterial Agents; D004917:Erythromycin