Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents.
A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones.
Kumar
Srinivas K
SK
Division of Experimental Therapeutics, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.
Hager
Erin
E
Pettit
Catherine
C
Gurulingappa
Hallur
H
Davidson
Nancy E
NE
Khan
Saeed R
SR
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002599:Chalcone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis; D051736:Proto-Oncogene Proteins c-mdm2; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D001896:Boron Compounds; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D002599:Chalcone; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2