[Cell cycle and checkpoints in oncology: new therapeutic targets].
Leland H. Hartwell, Paul M. Nurse et R. Timothy Hunt just received the Nobel price for their discovery of the molecular components of the cell cycle and cell cycle checkpoints. This review is an update of the molecular networks driving the cell cycle and its regulation, and of the importance of this knowledge for understanding the mechanisms driving oncogenesis and therapeutic developments.
Pommier
Yves
Y
Laboratoire de pharmacologie moléculaire, Center for Cancer Research, National Cancer Institute, Bldg 37, Room 5068, NIH, Bethesda, MD 20892-4255, USA. pommier@nih.gov
Kohn
Kurt W
KW
D000970:Antineoplastic Agents / Q000494:pharmacology; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology
D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins