[Signet ring cell carcinoma of the prostate successfully treated with endocrine therapy: a case report].
A 67-year-old man complained of dysuria. The prostate was enlarged and stony hard. The serum level of prostate specific antigen was abnormally high (46.2 ng/ml). Prostatic biopsy showed signet ring cells which were stained positive for prostate specific antigen and poorly differentiated adenocarcinoma. Computed tomographic scan revealed the enlargement of the para-aortic lymph nodes. Endocrine therapy with luteinizing hormone-releasing hormone agonist was started. After two months, the serum level of prostate specific antigen decreased to the normal range. The pathological findings and the good response to endocrine therapy in our case suggest that signet ring cell carcinoma of the prostate is only a morphologic variant of ordinary prostatic adenocarcinoma.
Ishizu
Kazuhiko
K
Department of Urology, Tsushimi Hospital.
Hirata
Hiroshi
H
Naito
Katsusuke
K
Sasaguri
Yasuyuki
Y
Saito
Akira
A
D000368:Aged; D018279:Carcinoma, Signet Ring Cell / Q000188:drug therapy* / Q000473:pathology; D004334:Drug Administration Schedule; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology
D007987:Gonadotropin-Releasing Hormone