Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents.
Four neutral gadolinium complexes of diethylenetriaminepentaacetic acid (DTPA)-bisamide derivatives have been synthesized and characterized. Their potential application as tissue-specific and low-osmolarity MRI contrast agents has been evaluated by in vitro and in vivo experiments. Their measured relaxivities in D(2)O, bovine serum albumin and human serum transferrin solutions showed favorable relaxation ability. In vivo studies have proven that Gd(DTPA-BDMA), Gd(DTPA-BIN), and Gd(cyclic-DTPA-1,2-pn) could be promising liver-specific MRI contrast agents and Gd(DTPA-BDMA), and Gd(cyclic-DTPA-1,2-pn) have favorable renal excretion capability. Among them, Gd(cyclic-DTPA-1,2-pn) is a more powerful hepatic contrast agent and Gd(DTPA-BIN) provides the stable imaging contrast for several hours. They also show a lower toxicity.
Feng
Jianghua
J
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
Sun
Guoying
G
Pei
Fengkui
F
Liu
Maili
M
D000577:Amides / Q000032:analysis / Q000737:chemistry; D000818:Animals; D003287:Contrast Media / Q000032:analysis* / Q000737:chemistry; D019786:Gadolinium DTPA / Q000032:analysis* / Q000737:chemistry; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000577:Amides; D003287:Contrast Media; D019786:Gadolinium DTPA