Factors associated with oropharyngeal human immunodeficiency virus shedding.
Orogenital transmission of human immunodeficiency virus (HIV) is considered to be inefficient, and infectious HIV is rarely detected in saliva. To evaluate the posterior oropharynx as a source of HIV shedding, we studied 64 HIV-infected men who have sex with men in Seattle, Washington, and Lima, Peru. In multivariate analysis, receipt of antiretroviral therapy, higher CD4 cell count, and history of tonsillectomy were predictors of lower pharyngeal HIV RNA levels.
Zuckerman
Richard A
RA
Department of Medicine, University of Washington, Seattle, Washington 98104, USA. zuckermn@u.washington.edu
Whittington
William L H
WL
Celum
Connie L
CL
Collis
Tarquin
T
Lucchetti
Aldo
A
Sanchez
Jorge L
JL
Hughes
James P
JP
Sanchez
Jose L
JL
Coombs
Robert W
RW
D000328:Adult; D015658:HIV Infections / Q000635:transmission; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009960:Oropharynx / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis; D017201:Virus Shedding
D012367:RNA, Viral