title: New steroidal alkaloids from Sarcococca saligna.
abstract: Two new steroidal alkaloids, salonine-A [(20S)-20-(N,N-dimethylamino)-3beta-(tigloylamino)-5alpha-pregn-14-en-2beta,4beta-diol] (1), and salonine-B [(20S)-20-(N,N-dimethylamino)-3beta-methoxy-pregn-5,16-diene] (2), were isolated from the MeOH extract of Sarcococca saligna, along with a known base, alkaloid-C (3). Their structures were elucidated on the basis of spectroscopic methods. All three compounds were found to be cholinesterase inhibitors.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.
authors.lastname: Atta-ur-Rahman
authors.forename: Fareeda
authors.initials: F
authors.lastname: Feroz
authors.lastname: Zaheer-ul-Haq
authors.forename: Sarfraz A
authors.initials: SA
authors.lastname: Nawaz
authors.forename: M Riaz
authors.initials: MR
authors.lastname: Khan
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D031234:Buxaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D011244:Pregnadienediols / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C478088:(20S)-20-(N,N-dimethylamino)-3beta-(tigloylamino)-5alpha-pregn-14-en-2beta,4beta-diol; C478089:(20S)-20-(N,N-dimethylamino)-3beta-methoxy-pregn-5,16-diene; D000470:Alkaloids; D004791:Enzyme Inhibitors; D011244:Pregnadienediols