title: Importance of CD4+ helper T-cells in antitumor immunity.
abstract: CD8+ cytotoxic T-lymphocytes are major effector cells involved in immunologically specific tumor destruction in vivo, and CD4+ T-cells are essential for controlling this CD8+ T-cell-dependent tumor eradication. The presence of CD4+ T-cells with distinct functional roles has been recognized. The further understanding of the complexity of antitumor immune responses by CD4+ T-cells may be crucial for designing more effective cancer vaccines.
authors.affiliation: Second Department of Internal Medicine, Mie University, School of Medicine, Tsu City, Japan. shiku@clin.medic.mie-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shiku
mesh_terms: D017951:Antigen Presentation; D006801:Humans; D007111:Immunity, Cellular; D009369:Neoplasms / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*