Use of Bordetella bronchiseptica and Bordetella pertussis as live vaccines and vectors for heterologous antigens.
Bordetella pertussis and Bordetella bronchiseptica are respiratory pathogens of humans and animals respectively. Unlike many bacteria, they are able to efficiently colonise healthy ciliated respiratory mucosa. This characteristic of Bordetella spp. can potentially be exploited to develop efficient live vaccines and vectors for delivery of heterologous antigens to the respiratory tract. Here we review the progress in this area.
Stevenson
Andrew
A
Molecular Bacteriology Group, Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, G61 1QH, Glasgow, UK.
Roberts
Mark
M
D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics* / Q000276:immunology; D001428:Bacterial Vaccines / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D016950:Bordetella bronchiseptica / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D001886:Bordetella pertussis / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D005822:Genetic Vectors; D006801:Humans; D018928:Immunity, Mucosal; D010567:Pertussis Vaccine / Q000276:immunology; D012137:Respiratory System / Q000378:metabolism / Q000382:microbiology; D014613:Vaccines, Attenuated / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology / Q000378:metabolism
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D010567:Pertussis Vaccine; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic