[Methylenetetrahydrofolate reductase [correction of reducatase] polymorphism and asthma].
OBJECTIVE
To evaluate the association between the methylenetetrahydrofolate reductase C/T polymorphism and the prevalence and course of asthma.


METHODS
Genotypes were determined in 433 asthmatic patients and 1 249 healthy subjects by the polymerase chain reaction and restriction fragment length polymorphism method.


RESULTS
The frequencies of the three genotypes were 40.27% for CC, 48.44% for CT, 11.29% for TT and the frequency of allelic T was 35.51% in controls. The frequency of TT genotype in atopic asthmatic patients was significantly higher than that in controls (P = 0.026). The OR for the TT genotype compared with all CC and CT genotypes was 1.61 (95% CI 1.06 approximately 2.47).


CONCLUSIONS
These results imply that homozygosity for this common mutation significantly increases the risk of atopic asthma.
Zou
Chao-chun
CC
The Children's Hospital of Zhejiang University School of Medicine, Hangzhoua 310003, China.
Tang
Lan-fang
LF
Jiang
Mi-zu
MZ
Zhao
Zheng-yan
ZY
Hirokazu
Tsukahara
T
Mitsufumi
Mayumi
M
D000328:Adult; D001249:Asthma / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D042965:Methylenetetrahydrofolate Reductase (NADPH2)