A new synthetic route to phomoidride B and its derivatives.
We have developed a new synthetic route to phomoidride B, which could also be applied to the synthesis of phomoidride B derivatives using Pd-catalyzed coupling reaction of a thiolester with an organozinc reagent. In addition, direct construction of the maleic anhydride moiety has been achieved by a Pd-catalyzed carbonylation reaction.
Hayashi
Yuki
Y
Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. [reaction: see text]
Itoh
Tetsuji
T
Fukuyama
Tohru
T
D002384:Catalysis; D008299:Maleic Anhydrides / Q000138:chemical synthesis* / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D017967:Zinc Compounds / Q000737:chemistry
C104957:CP 263114; D008299:Maleic Anhydrides; D009942:Organometallic Compounds; D017967:Zinc Compounds; D010165:Palladium