title: Pathways to recovery and loss of nephrons in anti-Thy-1 nephritis.
abstract: The present histopathologic study of anti-Thy-1.1 models of mesangioproliferative glomerulonephritis in rats provides a structural analysis of damage development and of pathways to recovery and to nephron loss. As long as the disease remains confined to the endocapillary compartment, the damage may be resolved or recover with a mesangial scar. Irreversible lesions with loss of nephrons emerge from extracapillary processes with crucial involvement of podocytes, leading to tuft adhesions to Bowman's capsule (BC) and subsequent crescent formation. Two mechanisms appeared to be responsible: (1) Epithelial cell proliferation at BC and the urinary orifice and (2) misdirected filtration and filtrate spreading on the outer aspect of the nephron. Both may lead to obstruction of the tubule, disconnection from the glomerulus, and subsequent degeneration of the entire nephron. No evidence emerged to suggest that the kind of focal interstitial proliferation associated with the degeneration of injured nephrons was harmful to a neighboring healthy nephron.
authors.affiliation: Institute of Anatomy and Cell Biology, University of Heidelberg, Im Neuenheimer Feld 307, D-69120 Heidelberg, Germany. wilhelm.kriz@urz.uni-heidelberg.de
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Kriz
authors.forename: Bruni
authors.initials: B
authors.lastname: Hähnel
authors.forename: Hiltraud
authors.initials: H
authors.lastname: Hosser
authors.forename: Tammo
authors.initials: T
authors.lastname: Ostendorf
authors.forename: Soeren
authors.initials: S
authors.lastname: Gaertner
authors.forename: Bettina
authors.initials: B
authors.lastname: Kränzlin
authors.forename: Norbert
authors.initials: N
authors.lastname: Gretz
authors.forename: Fujio
authors.initials: F
authors.lastname: Shimizu
authors.forename: Jürgen
authors.initials: J
authors.lastname: Floege
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002455:Cell Division; D004847:Epithelial Cells / Q000378:metabolism; D005920:Glomerular Mesangium / Q000473:pathology; D005921:Glomerulonephritis / Q000473:pathology; D007150:Immunohistochemistry; D007674:Kidney Diseases / Q000378:metabolism; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D009393:Nephritis / Q000473:pathology*; D009399:Nephrons / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012044:Regression Analysis; D018800:Thy-1 Antigens / Q000276:immunology*; D013997:Time Factors
chemical_list: D018800:Thy-1 Antigens