title: Plasma interleukin-6 is associated with psychological coronary risk factors: moderation by use of multivitamin supplements.
abstract: The current study examined the relation of plasma IL-6 to anger, hostility, and severity of depressive symptoms as a function of multivitamin supplement use in 96 healthy, nonsmoking men (aged 18-46). Plasma IL-6 was independently associated with anger, hostility, and severity of depressive symptoms, as well as with a composite factor score, but only among nonusers. Among users, these associations were not significant. Multivitamin use was associated with lower plasma IL-6 levels, but only among men with high composite factor scores. Statistical adjustments for age, body mass index, resting diastolic blood pressure, fasting total cholesterol, high-density lipoprotein cholesterol, alcohol use, exercise frequency, and educational level did not alter these results. These data suggest that plasma IL-6 is elevated among healthy men characterized by a propensity for anger, a hostile disposition, and greater severity of depressive symptoms and that multivitamin supplements could ameliorate plasma IL-6 levels among these men.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P.O. Box 3328, Durham, NC 27710, USA. ecs.jr@duke.edu
authors.forename: Edward C
authors.initials: EC
authors.lastname: Suarez
mesh_terms: D000293:Adolescent; D000328:Adult; D000786:Anger / Q000502:physiology*; D003324:Coronary Artery Disease / Q000517:prevention & control / Q000523:psychology; D003430:Cross-Sectional Studies; D003863:Depression / Q000097:blood*; D019587:Dietary Supplements; D006791:Hostility; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D012720:Severity of Illness Index; D014815:Vitamins / Q000097:blood* / Q000627:therapeutic use
chemical_list: D015850:Interleukin-6; D014815:Vitamins