Antiinflammatory therapy in myocarditis.
Acute viral myocarditis progresses through several stages, including acute viral infection, autoimmunity, and dilated cardiomyopathy. Recent studies have identified an important role for the myocardial inflammatory response during the initial phases of acute viral myocarditis. In this review, we discuss new insights into the innate host response to viral myocarditis and the various therapeutic strategies that have been attempted in managing the deleterious consequences of the myocardial inflammatory response in acute viral myocarditis.
Vallejo
Jesus
J
Winters Center for Heart Failure Research, Cardiology Section, Medical Care Line, Veterans Affairs Medical Center, and Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Mann
Douglas L
DL
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D006801:Humans; D007113:Immunity, Innate; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007167:Immunotherapy / Q000379:methods*; D008562:Membrane Glycoproteins / Q000378:metabolism; D009205:Myocarditis / Q000276:immunology* / Q000628:therapy* / Q000821:virology; D011956:Receptors, Cell Surface / Q000378:metabolism; D051193:Toll-Like Receptors
D000276:Adjuvants, Immunologic; D007166:Immunosuppressive Agents; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors