[The role of autoimmune process in the pathogenesis of hemorrhagic stroke].
Using immunologic study along with clinical and neurological ones, 104 patients in acute stage of hemorrhage stroke (18% of them with subarachnoidal; 27%--with parenchymatous and 55%--with combined hemorrhage) have been examined. A level of antibodies to DNA (anti-DNA) was determined in cerebrospinal fluid (CSF) and blood serum on 1, 10 and 20 days. Control group consisted of 20 persons. Anti-DNA was significantly elevated on day 1 in CSF and blood serum, with the most pronounced increasing in CSF (p < 0.001). The severer was hemorrhage stroke, the higher was anti-DNA level. Furthermore, the poorer was prognosis for recovery and life, the higher elevation was detected for anti-DNA.
Gerasimova
M M
MM
Antipina
Iu V
IuV
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood* / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D000974:Antibodies, Antinuclear