A series of infections due to Capnocytophaga spp in immunosuppressed and immunocompetent patients.
OBJECTIVE
To investigate the epidemiology, microbiology and outcome of infections caused by Capnocytophaga spp. at a single center.


METHODS
We report on ten documented infectious episodes caused by Capnocytophaga observed between 1994 and 1999 at the Innsbruck University Hospital.


RESULTS
In seven of ten patients, Capnocytophaga septicemia was diagnosed during periods of neutropenia. In contrast, the remaining three patients had normal white blood cell counts when acquiring Capnocytophaga septicemia (one) and pleural empyema (two). Blood cultures containing long, slender, Gram-negative rods, which grew slowly under anaerobic conditions and lacked susceptibility to metronidazole, were subcultivated in a CO2-enriched atmosphere (5%). Subcultivation yielded Capnocytophaga in all ten cases within 2-12 days. The patients were then placed on appropriate antibiotic therapy, with or without additional surgical intervention, and the organism was eradicated.


CONCLUSIONS
Identification of Capnocytophaga facilitates appropriate, and in most cases effective, antimicrobial therapy.
Bonatti
H
H
Department for General and transplant Surgery, Institute for Hygiene, University of Innsbruck, Innsbruck, Austria. Hugo.Bonatti@dr.com
Rossboth
D W
DW
Nachbaur
D
D
Fille
M
M
Aspöck
C
C
Hend
I
I
Hourmont
K
K
White
L
L
Malnick
H
H
Allerberger
F J
FJ
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002206:Capnocytophaga / Q000187:drug effects / Q000302:isolation & purification*; D024881:Drug Resistance, Bacterial; D016724:Empyema, Pleural / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D007121:Immunocompetence; D016867:Immunocompromised Host; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length
D000900:Anti-Bacterial Agents