Novel thiazolyl, thiazolinyl and benzothiazolyl Schiff bases as possible lipoxygenase's inhibitors and anti-inflammatory agents.
In continuation of our previous research, several new thiazolyl/thiazolinyl/benzothiazolyl Schiff bases have been designed, synthesized and identified. The referred compounds are reported to act as lipoxygenase inhibitors affecting inflammation and/or psoriasis. The compounds were screened for their reducing activity (with the stable free radical 1,1-diphenyl-2-picryl-hydrazyl, DPPH) and for inhibition of soybean lipoxygenase (LOX). Anti-inflammatory activity was examined in vivo using the carrageenin induced mice paw edema (32.6-75%). The results are discussed in terms of structural and physicochemical characteristics of the compounds. Compound 2d possessed the highest inhibition 75%.
Geronikaki
Athina
A
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki 54124, Greece.
Hadjipavlou-Litina
Dimitra
D
Amourgianou
Maria
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000737:chemistry*; D001713:Biphenyl Compounds; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D006834:Hydrazines; D008084:Lipoxygenase; D016859:Lipoxygenase Inhibitors / Q000627:therapeutic use*; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D010851:Picrates; D012545:Schiff Bases / Q000737:chemistry* / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D006834:Hydrazines; D016859:Lipoxygenase Inhibitors; D010851:Picrates; D012545:Schiff Bases; C004931:1,1-diphenyl-2-picrylhydrazyl; D008084:Lipoxygenase