Synthesis of 35-40 mers of RNA oligomers from unblocked monomers. A simple approach to the RNA world.
RNA oligomers greater than 35-40 mers in length form in one day in the montmorillonite clay-catalyzed reaction of unblocked RNA monomers at 25 degrees C in aqueous solution.
Huang
Wenhua
W
Department of Chemistry and New York Center for Studies on the Origins of Life, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA.
Ferris
James P
JP
D000225:Adenine / Q000031:analogs & derivatives*; D001546:Bentonite / Q000737:chemistry; D001704:Biopolymers / Q000737:chemistry; D003850:Deoxyribonuclease I; D015394:Molecular Structure; D009711:Nucleotides / Q000737:chemistry*; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D012313:RNA / Q000138:chemical synthesis*; D014529:Uridine / Q000737:chemistry
D001704:Biopolymers; D009711:Nucleotides; D009843:Oligoribonucleotides; D001546:Bentonite; C008407:1-methyladenine; D012313:RNA; D003850:Deoxyribonuclease I; D000225:Adenine; D014529:Uridine