Beta 3-adrenergic receptor is involved in feeding regulation in chicks.
We examined whether the brain beta 3-adrenergic receptor (B3-AR) is involved in the feeding regulation of chicks. Intracerebroventricular (ICV) injection of BRL37344, a B3-AR agonist, reduced food intake of chicks under ad libitum, but not fasting, feeding conditions. The ICV injection of BRL37344 did not affect chick posture or locomotion activity suggesting that BRL37344 inhibited feeding without induction of sleep-like behavior as caused by norepinephrine. Furthermore, the rectal temperature increased following the ICV injection of BRL37344. Intraperitoneal administration of BRL37344 did not reduce food intake under ad libitum feeding condition. The present study demonstrated that the brain B3-AR is involved in the inhibition of feeding in chicks. We also suggested that activation of the brain affects the energy metabolism in chicks.
Tachibana
Tetsuya
T
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University, 812-8581 Fukuoka, Japan. tetsu@brs.kyushu-u.ac.jp
Takagi
Tomo
T
Saito
Ei Suke
ES
Tomonaga
Shozo
S
Zhang
Rong
R
Koga
Yusuke
Y
Kido
Yasuhiro
Y
Michael Denbow
Donald
D
Furuse
Mitsuhiro
M
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002645:Chickens / Q000502:physiology*; D004435:Eating / Q000187:drug effects / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D004983:Ethanolamines / Q000494:pharmacology; D005215:Fasting; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D022702:Receptors, Adrenergic, beta-3 / Q000378:metabolism*; D012007:Rectum
D000316:Adrenergic alpha-Agonists; D058667:Adrenergic beta-3 Receptor Agonists; D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D022702:Receptors, Adrenergic, beta-3; C057368:BRL 37344; D009638:Norepinephrine