title: The relationship between activated protein C-resistance and recurrent abortion.
abstract: The activated protein C-resistance (APC-R) method based on APTT was used in 40 non-pregnant multiparas (control group) and 55 patients with abortion of unknown origin (experimental group) in order to explore the relationship between APC-R and recurrent abortion. A significant difference in APC-R-positive rate was found (P < 0.01) between control group and experimental group, with the rate being 5% in the controls and 25.5% in the experimental group. And the APC-R-positive rates in the patients with only twice abortions and the patients over-3-time abortions were 22.6% and 29.2%, respectively (P > 0.05). The APC-R-positive rate, which was 37.9% in the patients of late abortion, was much higher than that in the patients of early abortion. It is concluded that APC-R has something to do with recurrent abortion, and is closely related to late abortion, but bears no obvious relationship with times of abortions.
authors.affiliation: Department of Obstetrics and Gynecology, Xiehe Hospital, Tongji Medical University, Wuhan 430022.
authors.forename: W
authors.initials: W
authors.lastname: Dong
authors.forename: W
authors.initials: W
authors.lastname: Wei
authors.forename: M
authors.initials: M
authors.lastname: Lin
mesh_terms: D000026:Abortion, Habitual / Q000097:blood / Q000209:etiology*; D020016:Activated Protein C Resistance / Q000097:blood / Q000150:complications*; D000328:Adult; D005260:Female; D006801:Humans; D011247:Pregnancy; D011486:Protein C / Q000378:metabolism / Q000502:physiology; D020151:Protein C Deficiency / Q000097:blood / Q000150:complications
chemical_list: D011486:Protein C