title: Increased expression of nuclear factor-kappaB/RelA is correlated with tumor angiogenesis in human colorectal cancer.
abstract: OBJECTIVE
  Recent studies have shown that nuclear factor-kappa B/RelA (NF-kappa B/RelA) is involved in tumor angiogenesis. This study examined whether NF-kappa B/RelA expression is associated with vascular endothelial growth factor (VEGF) expression and microvessel density in human colorectal cancer.
  
  
  METHODS
  Ten specimens from normal colorectal mucosa and 52 colorectal adenocarcinomas were obtained by surgery or endoscopy. Immunohistochemical expression of NF-kappa B/RelA, VEGF, and CD34 was detected on paraffin-embedded tissue sections.
  
  
  RESULTS
  NF-kappa B/RelA and VEGF were significantly overexpressed and associated with microvessel density in colorectal cancer. A significant association was found between NF-kappa B/RelA and VEGF expression. Clinicopathological features were not correlated with NF-kappa B/RelA, VEGF expression, or microvessel density.
  
  
  CONCLUSIONS
  Our results suggest that increased expression of NF-kappa B/RelA contributes to tumor angiogenesis in colorectal cancer. VEGF may play an important role in mediating the NF-kappa B/RelA angiogenic pathway.
authors.affiliation: Department of Gastroenterology, Renmin Hospital of Wuhan Univeristy, Jiefang Road 238, 430060, Wuhan, China.
authors.forename: Hong-Gang
authors.initials: HG
authors.lastname: Yu
authors.forename: Xia
authors.initials: X
authors.lastname: Zhong
authors.forename: Yan-Ning
authors.initials: YN
authors.lastname: Yang
authors.forename: He-Sheng
authors.initials: HS
authors.lastname: Luo
authors.forename: Jie-Ping
authors.initials: JP
authors.lastname: Yu
authors.forename: Juris J
authors.initials: JJ
authors.lastname: Meier
authors.forename: Henning
authors.initials: H
authors.lastname: Schrader
authors.forename: Andreas
authors.initials: A
authors.lastname: Bastian
authors.forename: Wolfgang E
authors.initials: WE
authors.lastname: Schmidt
authors.forename: Frank
authors.initials: F
authors.lastname: Schmitz
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000378:metabolism; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D016328:NF-kappa B; D042461:Vascular Endothelial Growth Factor A