title: 4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs.
abstract: Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-aminopiperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9, active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Firenze, Via G. Capponi 9, I-50121, Firenze, Italy.
authors.forename: Dina
authors.initials: D
authors.lastname: Manetti
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Martini
authors.forename: Carla
authors.initials: C
authors.lastname: Ghelardini
authors.forename: Silvia
authors.initials: S
authors.lastname: Dei
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Galeotti
authors.forename: Luca
authors.initials: L
authors.lastname: Guandalini
authors.forename: Maria Novella
authors.initials: MN
authors.lastname: Romanelli
authors.forename: Serena
authors.initials: S
authors.lastname: Scapecchi
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Teodori
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bartolini
authors.forename: Fulvio
authors.initials: F
authors.lastname: Gualtieri
mesh_terms: D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003071:Cognition / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007202:Indicators and Reagents; D051379:Mice; D018727:Muscarinic Antagonists; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000473:pathology; D018697:Nootropic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D018091:Receptors, AMPA / Q000187:drug effects; D012601:Scopolamine; D013329:Structure-Activity Relationship
chemical_list: C481395:4-aminopiperidine; D007202:Indicators and Reagents; D018727:Muscarinic Antagonists; D018697:Nootropic Agents; D010880:Piperidines; D018091:Receptors, AMPA; D012601:Scopolamine