title: [Methods of screening for adult celiac disease in patients attending ambulatory care service in immunology].
abstract: BACKGROUND
  Coeliac disease (gluten sensitive enteropathy) is a very frequent disease appearing in variegated clinical form. In the last decade--concerning the immunogenetic and immunopathological aspects of the disease many of new recognition came to alight.
  
  
  OBJECTIVE
  As the disease can lay hidden in its non classical manifesting form for a very long time, authors wished to study the efficacy of screening, which may be introduced for patients attending immunological outpatient care service.
  
  
  RESULTS
  In the frame of nation-wide patient care, out of the 200 potential patients sent for immunological check up, various form of coeliac disease was diagnosed in 20 cases. Among these cases there are two--presented for the first time--which are connected to bone marrow transplantation. Based on the immunogenetics and autoantibody serology as well as on small intestine biopsies the following conclusions were made.
  
  
  CONCLUSIONS
  1. Coeliac disease in Hungary is very frequent. Hidden disease should be considered first of all in cases of malabsorption symptoms. 2. Demonstration of autoantibodies on wide-scale palette helps to state the diagnosis based on the systematic auto-immune disease connection. 3. Study of Human Leukocyte Antigen allotype (HLA-DQA1*0501/DQBI*02) applied as marker can considerably support the suspicion of disease. 4. Histology test of the small intestine cannot be omitted.
authors.affiliation: Országos Gyógyintézeti Központ, Immunológiai és Allergológiai Osztály, Budapest.
authors.forename: Katalin
authors.initials: K
authors.lastname: Kilián
authors.forename: Kata
authors.initials: K
authors.lastname: Miklós
authors.forename: Katalin
authors.initials: K
authors.lastname: Rajczy
authors.forename: Andrea
authors.initials: A
authors.lastname: Sipos
authors.forename: Lilla
authors.initials: L
authors.lastname: Lengyel
authors.forename: László
authors.initials: L
authors.lastname: Nemes
authors.forename: Gyözö
authors.initials: G
authors.lastname: Petrányi
authors.forename: Katalin
authors.initials: K
authors.lastname: Pálóczi
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000553:Ambulatory Care; D001323:Autoantibodies / Q000097:blood*; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology*; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged
chemical_list: D001323:Autoantibodies; D006683:HLA-DQ Antigens; D007136:Immunoglobulins