title: Sfh-I, a subclass B2 metallo-beta-lactamase from a Serratia fonticola environmental isolate.
abstract: An environmental isolate of Serratia fonticola resistant to carbapenems was shown to contain a genetic determinant encoding a metallo-beta-lactamase of the subclass B2. The Sfh-I enzyme exhibits some divergence from the previously characterized enzymes of this subclass. This is the first example of a naturally occurring metallo-beta-lactamase in Enterobacteriaceae.
authors.affiliation: Departmento de Higiene e Sanidade, ICETA, University of Trás-os-Montes e Alto Douro, Vila Real, Portugal.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Saavedra
authors.forename: Luísa
authors.initials: L
authors.lastname: Peixe
authors.forename: João Carlos
authors.initials: JC
authors.lastname: Sousa
authors.forename: Isabel
authors.initials: I
authors.lastname: Henriques
authors.forename: Artur
authors.initials: A
authors.lastname: Alves
authors.forename: António
authors.initials: A
authors.lastname: Correia
mesh_terms: D000595:Amino Acid Sequence; D015780:Carbapenems / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004777:Environment; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012705:Serratia / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D015780:Carbapenems; D012336:RNA, Ribosomal, 16S; D001618:beta-Lactamases