Calcium signalling: dynamics, homeostasis and remodelling.
Ca2+ is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes. An extensive Ca2+-signalling toolkit is used to assemble signalling systems with very different spatial and temporal dynamics. Rapid highly localized Ca2+ spikes regulate fast responses, whereas slower responses are controlled by repetitive global Ca2+ transients or intracellular Ca2+ waves. Ca2+ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.
Berridge
Michael J
MJ
Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK. michael.berridge@bbsrc.ac.uk
Bootman
Martin D
MD
Roderick
H Llewelyn
HL
D000818:Animals; D002118:Calcium / Q000502:physiology*; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015290:Second Messenger Systems / Q000502:physiology*
D015220:Calcium Channels; D002118:Calcium