title: Sinonasal tubulopapillary low-grade adenocarcinoma. Histopathological, immunohistochemical and ultrastructural features of poorly recognised entity.
abstract: We present the clinicopathological, histological and immunohistochemical findings of six cases of primary tubulopapillary low-grade adenocarcinoma of the sinonasal tract with ultrastructural examination in one case. Due to its unique features, we believe that primary tubulopapillary low-grade adenocarcinoma of the sinonasal tract represents a tumour entity different from any tumours generally recognised in the sinonasal region. Our cases had an equal sex incidence, with an age range of 44-76 years. The tumour has a tendency to recur, but none of our six patients developed metastases. We feel that it is important to separate this tumour entity from other types of sinonasal adenocarcinomas that exhibit a papillary growth pattern, as they frequently pursue a much more aggressive clinical course than the tumours in this study.
authors.affiliation: Medical Faculty Hospital, Charles University, Alej Svobody 80, 323 18 Plzen, Czech Republic.
authors.forename: A
authors.initials: A
authors.lastname: Skalova
authors.forename: A
authors.initials: A
authors.lastname: Cardesa
authors.forename: I
authors.initials: I
authors.lastname: Leivo
authors.forename: M
authors.initials: M
authors.lastname: Pfaltz
authors.forename: A
authors.initials: A
authors.lastname: Ryska
authors.forename: R
authors.initials: R
authors.lastname: Simpson
authors.forename: M
authors.initials: M
authors.lastname: Michal
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000231:Adenocarcinoma, Papillary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D008871:Microvilli / Q000648:ultrastructure; D008875:Middle Aged; D015388:Organelles / Q000648:ultrastructure; D010255:Paranasal Sinus Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor