Myosin-induced autoimmune myocarditis in BALB/C mice.
Experimental mice were immunized with cardiac myosin and complete Freund's adjuvant (CFA) on days 0, 7 and 30 and control mice were immunized with CFA. Sera and myocardium samples were harvested on days 15, 21 and 120 after the first immunization. Pathological findings demonstrated that there were necrosis and inflammatory infiltration in acute stage and fibrosis mainly in chronic stage of experimental group. Anti-myosin antibodies were also found in sera of experimental mice, but not in control group. Our study showed that cardiac myosin served as an autoantigen to provoke autoimmunity and lead to the transformation of VMC into DCM.
Wang
Z
Z
Institute of Cardiovascular Diseases, Tongji Medical University, Wuhan 430022.
Liao
Y
Y
Dong
J
J
Li
S
S
Wang
J
J
Tu
Y
Y
D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009205:Myocarditis / Q000139:chemically induced / Q000276:immunology / Q000473:pathology; D009218:Myosins
D001323:Autoantibodies; D009218:Myosins