Local anesthetic switching for intrathecal tachyphylaxis in cancer patients with pain.
Switching from bupivacaine to lidocaine may improve intrathecal morphine analgesia in advanced cancer patients, possibly because of different spinal mechanisms limiting the hyperalgesic processes.
Mercadante
S
S
Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy.
Villari
P
P
Ferrera
P
P
Arcuri
E
E
D000328:Adult; D000779:Anesthetics, Local / Q000009:adverse effects* / Q000627:therapeutic use*; D002045:Bupivacaine / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000150:complications; D016889:Endometrial Neoplasms / Q000150:complications; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000150:complications; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D010148:Intractable Pain / Q000188:drug therapy* / Q000209:etiology*; D010166:Palliative Care; D013274:Stomach Neoplasms / Q000150:complications; D013618:Tachyphylaxis / Q000502:physiology*; D002583:Uterine Cervical Neoplasms / Q000150:complications
D000779:Anesthetics, Local; D008012:Lidocaine; D002045:Bupivacaine