The oxytocin receptor.
Novel sites of oxytocin receptor expression have recently been detected, including breast cancer cells, bone cells, myoblasts, cardiomyocytes and endothelial cells. These discoveries have greatly expanded the possible spectrum of oxytocin action beyond its classic role as an inducer of uterine contractions and milk ejection. Additional advances in the understanding of oxytocin receptor structure-function relationships, receptor trafficking and novel receptor-linked signaling cascades have made this receptor an attractive model for the study of G-protein-linked receptor function. Finally, the tocolytic efficiency of the oxytocin receptor antagonist atosiban, recently approved for clinical use in Europe, has opened new avenues for the prevention and treatment of preterm labor.
Zingg
Hans H
HH
Laboratory of Molecular Endocrinology, McGill University Health Centre, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada. hans.zingg@mcgill.ca
Laporte
Stephane A
SA
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008024:Ligands; D018045:Receptors, Oxytocin / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D008024:Ligands; D018045:Receptors, Oxytocin