title: Subfield history: caloric restriction, slowing aging, and extending life.
abstract: Caloric restriction has resulted in a consistent robust increase in the maximal length of life in mammalian species. This article reviews significant advances over the long history of research on calorie restriction and longevity.
authors.affiliation: Department of Physiology at the University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. masoro@aol.com
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Masoro
mesh_terms: D000375:Aging / Q000502:physiology; D005075:Biological Evolution; D031204:Caloric Restriction / Q000266:history / Q000639:trends; D005947:Glucose / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008017:Life Expectancy; D008136:Longevity / Q000502:physiology; D008967:Molecular Biology; D018384:Oxidative Stress; D013312:Stress, Physiological / Q000378:metabolism
chemical_list: D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D005947:Glucose