title: Multiple copies of KIR 3DL/S1 and KIR 2DL4 genes identified in a number of individuals.
abstract: Multiple copies of the killer immunoglobulin-like receptor gene, 3DL/S1, have been identified in certain individuals. Additionally, allele determination of the killer immunoglobulin-like receptor gene (KIR), 2DL4, has identified three alleles of this gene present in these same individuals. This event has been confirmed by isolating three distinct KIR2DL4 allele clones in each individual, which sequenced as the alleles identified by the allele identification technique. It is our assumption that an unequal crossover event has occurred between differing KIR haplotypes resulting in the duplication of the 2DL4, 3DS1/3DL1 genes on the newly formed haplotype(s).
authors.affiliation: Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland. fionnuala.williams@bll.n-i.nhs.uk
authors.forename: Fionnuala
authors.initials: F
authors.lastname: Williams
authors.forename: Lynn D
authors.initials: LD
authors.lastname: Maxwell
authors.forename: Iris A
authors.initials: IA
authors.lastname: Halfpenny
authors.forename: Ashley
authors.initials: A
authors.lastname: Meenagh
authors.forename: Carole
authors.initials: C
authors.lastname: Sleator
authors.forename: Martin D
authors.initials: MD
authors.lastname: Curran
authors.forename: Derek
authors.initials: D
authors.lastname: Middleton
mesh_terms: D000483:Alleles; D018628:Gene Dosage; D020440:Gene Duplication; D015870:Gene Expression; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D016133:Polymerase Chain Reaction; D011971:Receptors, Immunologic / Q000235:genetics*; D054340:Receptors, KIR; D054345:Receptors, KIR2DL4; D054341:Receptors, KIR3DL1; D054349:Receptors, KIR3DS1; D017421:Sequence Analysis
chemical_list: C515079:KIR2DL4 protein, human; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054345:Receptors, KIR2DL4; D054341:Receptors, KIR3DL1; D054349:Receptors, KIR3DS1