What role for AID: mutator, or assembler of the immunoglobulin mutasome?
Activation-induced cytidine deaminase (AID) has been shown to trigger three mechanisms for diversifying immunoglobulin genes--somatic hypermutation, isotype switch recombination and gene conversion--most probably by initiating cytidine deamination at the immunoglobulin locus. Although this deamination process has been shown to be potentially mutagenic by itself, most of the mutations generated in the physiological hypermutation process seem to be created through the AID-mediated assembly of a mutasome complex involving specific repair activities and error-prone DNA polymerases.
Reynaud
Claude-Agnès
CA
INSERM U373, Faculté de Médecine Necker-Enfants Malades, 156 rue de Vaugirard, 75730 Paris Cedex 15, France.
Aoufouchi
Said
S
Faili
Ahmad
A
Weill
Jean-Claude
JC
D000818:Animals; D003564:Cytidine Deaminase / Q000502:physiology*; D004249:DNA Damage; D004259:DNA-Directed DNA Polymerase / Q000502:physiology; D005803:Genes, Immunoglobulin; D006801:Humans; D017393:RNA Editing; D027041:Somatic Hypermutation, Immunoglobulin; D014158:Transcription, Genetic; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D004259:DNA-Directed DNA Polymerase; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase