Macular pigment density and distribution: comparison of fundus autofluorescence with minimum motion photometry.
Macular pigment (MP) distribution profiles were measured for 18 subjects using a Moreland anomaloscope modified for motion photometry. The total amount of MP within the central 7 degrees was estimated from the distribution profile by numerical integration. Fundus autofluorescence images were obtained for eight of these subjects using a scanning laser ophthalmoscope. Peak optical density of MP increased with the total amount present, but the correlation was weakened by inter-subject differences in MP distribution. The mean MP distribution derived from mean grey-scale profiles of fundus autofluorescence images correlated closely with that obtained psychophysically (r=0.96). Autofluorescence imaging provides a fast non-invasive method for assessing MP in vivo.
Robson
Anthony G
AG
Moorfields Eye Hospital, City Road, London EC1V 2PD, UK.
Moreland
Jack D
JD
Pauleikhoff
Daniel
D
Morrissey
Tony
T
Holder
Graham E
GE
Fitzke
Fred W
FW
Bird
Alan C
AC
van Kuijk
Frederik J G M
FJ
D000375:Aging / Q000502:physiology; D005453:Fluorescence; D006801:Humans; D008266:Macula Lutea / Q000378:metabolism; D008268:Macular Degeneration / Q000209:etiology*; D009039:Motion Perception / Q000502:physiology; D019721:Ophthalmoscopes; D010783:Photometry / Q000379:methods; D012160:Retina / Q000502:physiology*; D012168:Retinal Pigments / Q000378:metabolism
D012168:Retinal Pigments