Is DNA cut out for a long life?
Much attention has been focused on the DNA repair hypothesis of aging. Studies in mammals that seek to test the validity of this model are complicated by both the functional redundancy and the essential nature of genes involved in the repair process. Compared to mammals, the study of DNA repair and aging in yeast has considerably fewer complicating factors. In this Perspective, I discuss results presented in this month's issue of Aging Cell that address whether the types of DNA damage repaired by the base excision repair pathway cause aging in yeast.
Sinclair
David
D
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. David_Sinclair@hms.harvard.edu
D000375:Aging / Q000235:genetics*; D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D004271:DNA, Fungal; D008136:Longevity / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D017382:Reactive Oxygen Species; D012441:Saccharomyces cerevisiae / Q000235:genetics*
D004271:DNA, Fungal; D017382:Reactive Oxygen Species