Primary B-cell lymphoma and lymphoma-like lesions of the uterine cervix.
We present three patients with atypical lymphoid cells on cervical smear screening, with diffuse large-cell B-cell lymphoma diagnosed by morphology on cervical biopsy. One patient with extensive pelvic disease was treated with chemotherapy and radiotherapy and remained in remission 8 years later. Two patients with presumed stage 1E lesions showed spontaneous regression on repeat cervical biopsy, despite light chain restriction and clonal immunoglobulin gene rearrangement. They are without recurrent malignancy 1 and 5 years after their initial diagnosis. The presence of malignant looking lymphoid cells on cervical smear should be investigated by repeated colposcopic biopsies. The reason for the highly skewed atypical B-cell lymphoproliferation in lymphoma-like lesions of the cervix is unknown. With early stage, nonbulky cervical lymphoma in an otherwise healthy patient, a cone biopsy is advised. A number of these lesions may regress even when clonal populations are detected.
Au
W Y
WY
Department of Medicine, Obstetrics and Gynecology, Queen Mary Hospital, Hong Kong SAR, China. auwing@hotmail.com
Chan
B C P
BC
Chung
L P
LP
Choy
C
C
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D001706:Biopsy; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000145:classification / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D008875:Middle Aged; D010298:Parity; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology*