title: Treatment of plastic bronchitis in acute chest syndrome of sickle cell disease with intratracheal rhDNase.
abstract: Plastic bronchitis, a condition associated with widespread mucous plugging of the tracheobronchial tree, is an increasingly recognised bronchoscopic finding in acute chest syndrome of sickle cell disease. Removal of casts by bronchoscopy is technically challenging. We describe a child with acute chest syndrome where bronchoscopic removal of extensive tracheobronchial plastic casts was facilitated by intratracheal rhDNase.
authors.affiliation: Paediatric Intensive Care Unit, Guy's Hospital, London, UK.
authors.forename: S S
authors.initials: SS
authors.lastname: Manna
authors.forename: J
authors.initials: J
authors.lastname: Shaw
authors.forename: S M
authors.initials: SM
authors.lastname: Tibby
authors.forename: A
authors.initials: A
authors.lastname: Durward
mesh_terms: D000208:Acute Disease; D000755:Anemia, Sickle Cell / Q000150:complications*; D001991:Bronchitis / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D003850:Deoxyribonuclease I / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; C085693:DNASE1 protein, human; D003850:Deoxyribonuclease I