New approaches to chromatographic determination of lipophilicity of xenobiotics.
Liquid chromatography and capillary electrophoresis are unique tools for fast and efficient modeling of pharmacokinetic properties of drug candidates. Therefore numerous new separation methods and procedures have very recently been introduced to facilitate the high-throughput screening of biopartitioning features of xenobiotics. This report is a concise, up-to-date review of progress in the chromatographic assessments of data of importance for medicinal chemistry and molecular pharmacology.
Kaliszan
Roman
R
Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gen. J. Hallera 107, 80-416, Gdańsk, Poland. roman.kaliszan@amg.gda.pl
Nasal
Antoni
A
Markuszewski
Michał Jan
MJ
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000295:instrumentation / Q000379:methods*; D008055:Lipids / Q000032:analysis*; D015262:Xenobiotics / Q000737:chemistry* / Q000302:isolation & purification
D008055:Lipids; D015262:Xenobiotics