title: Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research.
abstract: The application of state-of-the-art proteomics and functional genomics technologies to the study of cancer is rapidly shifting toward the analysis of clinically relevant samples derived from patients, as the ultimate aim of translational research is to bring basic discoveries closer to the bedside. Here we describe the essence of a long-term initiative undertaken by The Danish Centre for Translational Breast Cancer Research and currently underway for cancer biomarker discovery using fresh tissue biopsies and bio-fluids. The Centre is a virtual hub that brings together scientists working in various areas of basic cancer research such as cell cycle control, invasion and micro-environmental alterations, apoptosis, cell signaling, and immunology, with clinicians (oncologists, surgeons), pathologists, and epidemiologists, with the aim of understanding the molecular mechanisms underlying breast cancer progression and ultimately of improving patient survival and quality of life. The unifying concept behind our approach is the use of various experimental paradigms for the prospective analysis of clinically relevant samples obtained from the same patient, along with the systematic integration of the biological and clinical data.
authors.affiliation: The Danish Centre for Translational Breast Cancer Research, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. jec@cancer.dk
authors.forename: Julio E
authors.initials: JE
authors.lastname: Celis
authors.forename: Pavel
authors.initials: P
authors.lastname: Gromov
authors.forename: Irina
authors.initials: I
authors.lastname: Gromova
authors.forename: José M A
authors.initials: JM
authors.lastname: Moreira
authors.forename: Teresa
authors.initials: T
authors.lastname: Cabezón
authors.forename: Noona
authors.initials: N
authors.lastname: Ambartsumian
authors.forename: Mariam
authors.initials: M
authors.lastname: Grigorian
authors.forename: Eugene
authors.initials: E
authors.lastname: Lukanidin
authors.forename: Per
authors.initials: P
authors.lastname: Thor Straten
authors.forename: Per
authors.initials: P
authors.lastname: Guldberg
authors.forename: Jirina
authors.initials: J
authors.lastname: Bartkova
authors.forename: Jiri
authors.initials: J
authors.lastname: Bartek
authors.forename: Jiri
authors.initials: J
authors.lastname: Lukas
authors.forename: Claudia
authors.initials: C
authors.lastname: Lukas
authors.forename: Anne
authors.initials: A
authors.lastname: Lykkesfeldt
authors.forename: Marja
authors.initials: M
authors.lastname: Jäättelä
authors.forename: Peter
authors.initials: P
authors.lastname: Roepstorff
authors.forename: Lars
authors.initials: L
authors.lastname: Bolund
authors.forename: Torben
authors.initials: T
authors.lastname: Ørntoft
authors.forename: Nils
authors.initials: N
authors.lastname: Brünner
authors.forename: Jens
authors.initials: J
authors.lastname: Overgaard
authors.forename: Kerstin
authors.initials: K
authors.lastname: Sandelin
authors.forename: Mogens
authors.initials: M
authors.lastname: Blichert-Toft
authors.forename: Henning
authors.initials: H
authors.lastname: Mouridsen
authors.forename: Fritz E
authors.initials: FE
authors.lastname: Rank
mesh_terms: D000047:Academies and Institutes; D014408:Biomarkers, Tumor; D035843:Biomedical Research / Q000639:trends*; D001706:Biopsy; D001826:Body Fluids / Q000737:chemistry; D001943:Breast Neoplasms / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D003718:Denmark; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D020869:Gene Expression Profiling; D023281:Genomics; D006801:Humans; D042361:Mammary Glands, Human / Q000473:pathology; D010865:Pilot Projects; D040901:Proteomics; D013048:Specimen Handling
chemical_list: D014408:Biomarkers, Tumor