[Adult primary myelodysplastic syndromes. Report of 36 cases].
Between 1989 and 1999, 36 cases with primary myelodysplastic syndromes were diagnosed. They were 15 male and 21 females, the median age was 62 years (range: 22 to 90 years). Eighty one per cent of patients were presented symptoms of anemia. Lymphadenopathy, splenomegaly and skin manifestations were noted in 25% of cases. Hemogram showed anemia, leucopenia and thrombocytopenia respectively in 97%, 44% and 55% of cases. Refractory anemia with excess blasts (AREB) is the most frequent FAB subtypes of MDS (17 cases). Cytogenetic study concerned 24 patients. In 13 cases the karyotype was pathological with deletion 5 q in 64% of cases. Seventeen patients have received a chemotherapy. Survival rate to 36 months is 11%. At the time, the only curative treatment is the bone marrow transplantation, which is proposed to young patients with HLA identical donor.
Khalifa
Mabrouk
M
Service d'Hématologie Clinique, CHU F. Hached de Sousse, Tunisie.
Laatiri
Mohamed Adnène
MA
Chehata
Sami
S
Rhaiem
Kaief
K
Gharbi
Olfa
O
Amama
Wafa
W
Ennabli
Souad
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000754:Anemia, Refractory, with Excess of Blasts / Q000209:etiology*; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000209:etiology; D008206:Lymphatic Diseases / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D012871:Skin Diseases / Q000209:etiology; D013163:Splenomegaly / Q000209:etiology; D013921:Thrombocytopenia / Q000209:etiology