title: Influence of fragment reaction of relativistic heavy charged particles on heavy-ion radiotherapy.
abstract: The production of projectile fragments is one of the most important, but not yet perfectly understood, problems to be considered when planning for the utilization of high-energy heavy charged particles for radiotherapy. This paper reports our investigation of the fragments' fluence and linear energy transfer (LET) spectra produced from various incident ions using an experimental approach to reveal these physical qualities of the beams. Polymethyl methacrylate, as a substitute for the human body, was used as a target. A deltaE-E counter telescope with a plastic scintillator and a BGO scintillator made it possible to identify the species of fragments based on differences of various elements. By combining a gas-flow proportional counter with a counter telescope system, LET spectra as well as fluence spectra of the fragments were derived for each element down from the primary particles to hydrogen. Among them, the information on hydrogen and helium fragments was derived for the first time. The result revealed that the number of light fragments, such as hydrogen and helium, became larger than the number of primaries in the vicinity of the range end. However, the greater part of the dose delivered to a cell was still governed by the primaries. The calculated result of a simulation used for heavy-ion radiotherapy indicated room for improving the reaction model.
authors.affiliation: Department of Accelerator Physics and Engineering, National Institute of Radiological Sciences, 263-8555 Chiba, Japan. matufuji@nirs.go.jp
authors.forename: Naruhiro
authors.initials: N
authors.lastname: Matsufuji
authors.forename: Akifumi
authors.initials: A
authors.lastname: Fukumura
authors.forename: Masataka
authors.initials: M
authors.lastname: Komori
authors.forename: Tatsuaki
authors.initials: T
authors.lastname: Kanai
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kohno
mesh_terms: D007477:Ions; D018499:Linear Energy Transfer; D019904:Polymethyl Methacrylate / Q000528:radiation effects*; D011789:Quantum Theory; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods*; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000295:instrumentation* / Q000379:methods*; D012542:Scattering, Radiation
chemical_list: D007477:Ions; D019904:Polymethyl Methacrylate