[An epidemiological study on the index cases of severe acute respiratory syndrome occurred in different cities among Guangdong province].
OBJECTIVE
To analyze the epidemiological features of the index cases of severe acute respiratory syndrome (SARS) occurred in different cities in Guangdong province and to trace for the source of infection.


METHODS
Standardized individual case inventory was adopted to conduct investigation on index cases and on persons who had close contact with index cases in Guangdong province. Data on the epidemiological characteristics, secondary cases and the links among index cases were analyzed.


RESULTS
Between November 16, 2002 and April 16, 2003, there had been 13 index cases of SARS including 3 cadres, 3 farmers, 2 retirees, 2 workers and 1 shop attendant, reported from 13 cities in Guangdong province. Between November 2002 and January 2003, there had been 7 cities reported to have identified index cases of SARS with 6 of them being infected in their own cities and 1 imported from Guangzhou city. All of the cases had no close contacts to similar patients but 6 of them later caused 2nd or even 3rd generation cases of SARS. Most cases hit young people (7/13) with a sex ratio of 1:0.6. The fatality rate of index cases was high (4/13).


CONCLUSIONS
No evidence showed that there was direct transmission among the index cases. Data regarding the geographical origin of those index cases led to the assumption that the infection had started in six cities of Pearl river delta region and the Hong Kong Special Administrative Region.
He
Jian-feng
JF
Center for Disease Control and Prevention of Guangdong Province, Guangzhou 510300, China.
Peng
Gou-wen
GW
Zheng
Hui-zhen
HZ
Luo
Hui-ming
HM
Liang
Wen-jia
WJ
Li
Ling-hui
LH
Guo
Ru-ning
RN
Deng
Zhuo-hui
ZH
D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D016358:Contact Tracing; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D045169:Severe Acute Respiratory Syndrome / Q000453:epidemiology* / Q000635:transmission