title: Mortality in candidates waiting for combined liver-intestine transplants exceeds that for other candidates waiting for liver transplants.
abstract: The United Network for Organ Sharing (UNOS) reports indicate that mortality on the intestine transplant waiting list is higher than on other transplant waiting lists. The goals of this study were (1) to determine whether most of the intestinal transplant candidate deaths have occurred in those who also need liver transplants, and (2) to compare the waiting list mortality in the liver-intestine candidate subset with the overall liver transplant candidate population. We found that 90% of intestine transplant waiting list deaths have occurred in candidates who also needed liver transplants. Since 1994, annual mortality has been higher in liver-intestine transplant candidates than in the overall liver transplant candidate population, and these differences have been statistically significant since 1996. These mortality differences applied to all age groups. Also, status 2B, 3, and 7 candidate mortality was significantly higher in liver-intestine candidates than in the overall liver transplant candidate population. Because there were so few liver-intestine transplant candidates listed as status 1 or 2A, a meaningful comparison was not possible in these statuses. These data indicate that liver-intestine transplant candidates are a unique subset of liver transplant candidates with a significantly higher risk of dying on the waiting list. Recent changes in UNOS liver allocation policy that gives higher priority to liver-intestine candidates may help to reduce this discrepancy. However, further research into the etiology of liver disease in patients on long-term parenteral nutrition and earlier referral of high-risk short bowel syndrome patients to centers with special expertise in their management are needed for an ultimate solution to this problem.
authors.affiliation: Department of Surgery, Northwestern University Medical School, Chicago, IL 60611, USA. jfryer@nmh.org
authors.forename: Jonathan
authors.initials: J
authors.lastname: Fryer
authors.forename: Suzanne
authors.initials: S
authors.lastname: Pellar
authors.forename: Debra
authors.initials: D
authors.lastname: Ormond
authors.forename: Allan
authors.initials: A
authors.lastname: Koffron
authors.forename: Michael
authors.initials: M
authors.lastname: Abecassis
mesh_terms: D000328:Adult; D002648:Child; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications* / Q000401:mortality / Q000601:surgery*; D007422:Intestines / Q000637:transplantation*; D017093:Liver Failure / Q000150:complications* / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation; D012778:Short Bowel Syndrome / Q000150:complications / Q000401:mortality / Q000601:surgery; D016019:Survival Analysis; D013997:Time Factors; D014850:Waiting Lists