title: Graphical analysis of 99mTc thyroid scintigraphy.
abstract: A new non-invasive simple method for quantitative evaluation of thyroid was presented using graphical analysis of the transfer process of technetium-99m pertechnetate (99mTc) from the blood to thyroid. Thirty subjects were studied. After a bolus injection of 111 MBq of 99mTc, the data were recorded on a 128 x 128 matrix as 60 frames of 1.5-second duration. ROIs were placed over the aortic arch and bilateral thyroid lobes. The activity of the aorta was monitored instead of the arterial activity. Graphical analysis by plotting B(t)/A(t) versus integral(0)t A(tau)d tau/A(t) gave a straight line within the first 30 seconds in all subjects. The slope of the line was the unidirectional influx rate of 99mTc (k(u)). Thyroid perfusion index (TPI) was calculated to standardize where the ratio of ROI(thyroid) size to ROI(aorta) size was set as 10. K(u) and TPI showed good correlation with 99mTc thyroid uptake. Hyperthyroid patients showed high values of k(u) and TPI. Considering that these indices were determined at the first pass of 99mTc, this method may be helpful especially in the evaluation of thyroid perfusion.
authors.affiliation: Department of Radiology, Narita Red Cross Hospital, Chiba, Japan. junokada@cocoa.plala.or.jp
authors.forename: Junichi
authors.initials: J
authors.lastname: Okada
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Higashitsuji
authors.forename: Hajime
authors.initials: H
authors.lastname: Tamada
authors.forename: Osamu
authors.initials: O
authors.lastname: Kawashiro
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Fukuzaki
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hisao
authors.initials: H
authors.lastname: Itou
mesh_terms: D000465:Algorithms; D006111:Graves Disease / Q000097:blood / Q000000981:diagnostic imaging; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008954:Models, Biological; D011865:Radioisotope Dilution Technique; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000097:blood / Q000493:pharmacokinetics; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013667:Technetium / Q000097:blood* / Q000493:pharmacokinetics; D013960:Thyroid Function Tests / Q000379:methods; D013961:Thyroid Gland / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000378:metabolism; D013972:Thyrotropin / Q000097:blood
chemical_list: D019275:Radiopharmaceuticals; D013667:Technetium; D013972:Thyrotropin