MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation.
That signalling pathways, particularly the mitogen-activated protein kinase cascades, elicit modification of chromatin proteins such as histone H3 by phosphorylation and/or acetylation concomitant with gene activation is now well established. The picture that is emerging is one of a complex and dynamic pattern of multiple modifications at the H3 tail. Here, we review the inducible gene systems where H3 modifications have been reported and re-evaluate the controversy as to the kinase(s) that phosphorylates it as well as the proposed coupling between H3 phosphorylation and acetylation.
Clayton
Alison L
AL
Nuclear Signalling Laboratory, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
Mahadevan
Louis C
LC
D000107:Acetylation; D000818:Animals; D005786:Gene Expression Regulation; D017781:Genes, Immediate-Early; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D020935:MAP Kinase Signaling System; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism; D015533:Transcriptional Activation
D006657:Histones; D015534:Trans-Activators; D020928:Mitogen-Activated Protein Kinases