title: Model-free treatment of the dehydration kinetics of nedocromil sodium trihydrate.
abstract: The conventional model-fitting approach to kinetic analysis assumes a fixed mechanism throughout the reaction and therefore may be too simplistic for many solid-state reactions. Even for a reaction with a fixed mechanism, model fitting sometimes cannot identify the reaction model uniquely. The alternative model-free approach is sufficiently flexible to allow for a change of mechanism during the course of a reaction and therefore provides a more realistic treatment of solid-state reactions kinetics. The application of model-free analysis to solid-state dehydrations was investigated using the two consecutive dehydration reactions of nedocromil sodium trihydrate. The complexity of such reactions is illustrated by the variation of the activation energy as each dehydration proceeds. The 1st-step dehydration follows one-dimensional phase boundary kinetics until the fraction dehydrated reaches 0.75, and deviates from this model thereafter. The 2nd-step dehydration follows a mechanism intermediate between two- and three-dimensional diffusion that cannot be described by any of the common models. The model-free approach is clearly better than the model-fitting approach for understanding the details of these solid-state dehydration reactions.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Weaver-Densford Hall, 308 Harvard Street SE, Minneapolis, MN 55455-0343, USA.
authors.forename: Deliang
authors.initials: D
authors.lastname: Zhou
authors.forename: Eric A
authors.initials: EA
authors.lastname: Schmitt
authors.forename: Geoff G Z
authors.initials: GG
authors.lastname: Zhang
authors.forename: Devalina
authors.initials: D
authors.lastname: Law
authors.forename: Charles A
authors.initials: CA
authors.lastname: Wight
authors.forename: Sergey
authors.initials: S
authors.lastname: Vyazovkin
authors.forename: David J W
authors.initials: DJ
authors.lastname: Grant
mesh_terms: D003890:Desiccation / Q000295:instrumentation / Q000379:methods; D007700:Kinetics; D008956:Models, Chemical; D017835:Nedocromil / Q000737:chemistry* / Q000493:pharmacokinetics*
chemical_list: D017835:Nedocromil