title: [Intravenous catheter occlusion during continuous infusion of a new recombinant factor VIII concentrate].
abstract: We experienced catheter occlusion in two cases during continuous infusion of a new recombinant factor VIII concentrate (Kogenate FS, Bayer) during orthopedic surgery. In one of the cases, the infusion was completed by diluting Kogenate FS 1:4 with distilled water. These catheter occlusions might be caused by local clot formation due to the relatively high concentration of factor VIII in the continuous infusion route.
authors.affiliation: Department of Orthopaedic Surgery, National Sanatorium Fukui Hospital.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Takedani
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Abe
authors.forename: Masue
authors.initials: M
authors.lastname: Kajiwara
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kuwata
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D002406:Catheterization, Peripheral / Q000009:adverse effects*; D005169:Factor VIII / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures; D011994:Recombinant Proteins / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: D011994:Recombinant Proteins; C078147:F8 protein, human; D005169:Factor VIII