Drug-induced sweat gland necrosis in a non-comatose patient: a case presentation.
BACKGROUND
Coma-induced bullae and sweat gland necrosis is a rare clinicopathological entity often associated with drug-induced coma.


METHODS
We report a case with clinical and histopathologic findings characteristic of blisters and sweat gland necrosis occurring in a non-comatose patient.


CONCLUSIONS
Skin blisters with underlying sweat gland necrosis is an entity previously reported to occur in comatose patients, our findings open new questions about the role of the drugs in the pathogenesis of those conditions.
Ferreli
C
C
Department of Dermatology University of Cagliari, Cagliari, Italy. ferreli@unica.it
Sulica
V I
VI
Aste
N
N
Atzori
L
L
Pinna
M
M
Biggio
P
P
D000328:Adult; D001007:Anxiety / Q000188:drug therapy; D001707:Biopsy, Needle; D001768:Blister / Q000139:chemically induced* / Q000473:pathology*; D001960:Bromazepam / Q000009:adverse effects* / Q000627:therapeutic use; D003128:Coma; D005260:Female; D005445:Flunitrazepam / Q000009:adverse effects* / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D009336:Necrosis; D035583:Rare Diseases; D018570:Risk Assessment; D013545:Sweat Glands / Q000473:pathology*
D005445:Flunitrazepam; D001960:Bromazepam