Diet, individual responsiveness and cancer prevention.
Dietary recommendations for the prevention of cancer have been based predominantly on large epidemiological studies of diet and lifestyle, conducted 20, and in some cases, almost 30 years ago. Government programs have been successful in educating the public about the benefits of eating fruits and vegetables, yet despite these efforts, Americans have become heavier, diabetes is more prevalent and general health indicators have not greatly improved. Individual response to dietary recommendations may be complicated by a variety of factors. Polymorphisms in genes related to drug activation and detoxification, folate metabolism, DNA repair, vitamin receptors and other cellular receptors could account for a lack of benefit at the level of the individual for consuming cancer preventive foods. Beyond consideration of genetic polymorphisms, the last half century has brought stark changes in lifestyle that depart from normal diurnal cycle and periodic fluctuations in food availability. Thus, modern times may be characterized as being constantly in a "feast" environment. The cellular consequences may be an increase in risk for several diseases including cancer.
Wargovich
Michael J
MJ
Department of Pathology and Microbiology, University of South Carolina School of Medicine and South Carolina Cancer Center, Columbia, SC 29203, USA. michael.wargovich@palmettohealth.org
Cunningham
Joan E
JE
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004032:Diet; D005260:Female; D006801:Humans; D008019:Life Style; D009369:Neoplasms / Q000517:prevention & control*; D009765:Obesity / Q000453:epidemiology / Q000209:etiology; D011110:Polymorphism, Genetic; D014481:United States / Q000453:epidemiology
D003577:Cytochrome P-450 Enzyme System