Successful liver transplantation in a patient with sickle-cell anaemia.
Liver transplantation in the setting of sickle-cell anaemia poses several new challenges to the transplant team. Hypoxaemia, acidosis and a decrease in body temperature are common occurrences that can cause sickling in the peri-operative period, putting the patient at risk of sickle-cell crises or graft dysfunction. We describe a patient with sickle-cell anaemia who successfully underwent transplantation, and we discuss the rationale of various precautions that had to be taken.
van den Hazel
Sven J
SJ
Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center of Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
Metselaar
Herold J
HJ
Tilanus
Hugo W
HW
IJzermans
Jan N
JN
Groenland
Theo H N
TH
Visser
Loes
L
de Man
Robert A
RA
D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D006501:Hepatic Encephalopathy / Q000150:complications* / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D011300:Preoperative Care; D016896:Treatment Outcome