Lipid metabolism in hypercholesterolemic rats affected by feeding cholesterol-free diets containing different amounts of non-dialyzed soybean protein fraction.
OBJECTIVE
We investigated lipid metabolism in hypercholesterolemic rats after replacing casein with different amounts of undialyzed soybean protein fraction.


METHODS
The hypercholesterolemic rats were fed cholesterol-free diets containing 2%, 5%, or 10% undialyzed soybean protein fraction (UDSP) for 4 wk.


RESULTS
The 5% and 10% UDSP groups had significantly lower plasma cholesterol, triacylglycerol, and low-density lipoprotein cholesterol concentrations than did the other groups (P < 0.05). In addition, significantly higher fecal total steroid excretion was observed in these two groups. However, the different amounts of UDSP did not influence liver lipid, plasma high-density lipoprotein cholesterol, body weight gain, daily food intake, or feeding efficiency.


CONCLUSIONS
These results suggested a dose-dependent reduction in plasma cholesterol when casein was replaced stepwise with UDSP (5% or 10%) as a protein source. The hypocholesterolemic effect might have been due to an increase in total fecal steroid excretion.
Chen
Jiun Rong
JR
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan.
Chiou
Shiau Fang
SF
Suetsuna
Kunio
K
Yang
Hsin Yi
HY
Yang
Suh Ching
SC
D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000737:chemistry; D006937:Hypercholesterolemia / Q000178:diet therapy / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D030262:Soybean Proteins / Q000008:administration & dosage*; D013261:Sterols / Q000032:analysis; D014280:Triglycerides / Q000097:blood
D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D008055:Lipids; D030262:Soybean Proteins; D013261:Sterols; D014280:Triglycerides; D002784:Cholesterol