Binding of D-mannose to poly(2-hydroxyethyl methacrylate) hydrogels by azo coupling.
Crosslinked hydrogels based on poly(2-hydroxyethyl methacrylate) poly(HEMA) were prepared and modified with tyramine [4-(2-aminoethyl)phenol] to enable azo coupling with mannosyl derivatives, copolymerization of HEMA with polymerizable activated esters and surface modification reaction with 4-nitrophenyl chlorocarbonate for activation of the hydrogels were used.
Labský
Jirí
J
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. labsky@imc.cas.cz
D001672:Biocompatible Materials; D004952:Esters; D005561:Formates / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D015603:Keratinocytes / Q000378:metabolism; D008358:Mannose / Q000737:chemistry*; D008956:Models, Chemical; D009596:Nitrophenols / Q000737:chemistry*; D011102:Polyhydroxyethyl Methacrylate / Q000031:analogs & derivatives* / Q000737:chemistry*; D011108:Polymers; D014439:Tyramine / Q000737:chemistry*
D001672:Biocompatible Materials; D004952:Esters; D005561:Formates; D020100:Hydrogels; D009596:Nitrophenols; D011108:Polymers; C024719:4-nitrophenyl; D011102:Polyhydroxyethyl Methacrylate; C023037:poly(2-hydroxyethyl acrylate); D008358:Mannose; D014439:Tyramine