Improved pulmonary artery buffering function during phenylephrine-induced pulmonary hypertension.
The goal of this study was to determine the in vivo pulmonary arterial buffering function (BF) during acute and moderate pulmonary hypertension achieved by phenylephrine-induced smooth muscle activation. Pulmonary pressure (Konigsberg P7) and diameter (sonomicrometry) were measured in nine anesthetized sheep. Transit pulmonary arterial hypertension was induced by mechanical occlusion of the pulmonary artery (HP) and by phenylephrine infusion (5 microg/kg/min) (PHE). A viscoelastic Kelvin-Voigt model was used. By increasing the values of the viscous modulus, the pressure-diameter hysteresis area was reduced to a minimum in order to obtain the purely elastic pressure-diameter relationship. The elastic index (E) was calculated as the first derivative of the exponential model of the purely elastic pressure-diameter relationship at the mean pressure point. Systolic, diastolic, mean and pulse pressures were similar during HP and PHE, but significantly higher with regard to control steady state. In HP, E and arterial diameter (both its minimum and maximum values) increased significantly. In contrast, when pulmonary hypertension was induced by VSM activation, E was maintained concomitantly with pulmonary artery vasoconstriction. Pulmonary hypertension produced by occlusion of the pulmonary artery increases elasticity. Smooth muscle activation may offset the deleterious effect of pulmonary hypertension on arterial wall elasticity by reducing E and impeding arterial dilatation and collagen recruitment, maintaining BF during pulmonary hypertension.
Bia
Daniel
D
Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. dbia@fmed.edu.uy
Grignola
Juan C
JC
Armentano
Ricardo L
RL
Ginés
Fernando F
FF
D000818:Animals; D001794:Blood Pressure; D004548:Elasticity; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000503:physiopathology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000503:physiopathology; D010656:Phenylephrine / Q000008:administration & dosage; D011651:Pulmonary Artery / Q000503:physiopathology*; D012756:Sheep; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology
D010656:Phenylephrine