Multiplex stress resistance in cells from long-lived dwarf mice.
Mutations that extend nematode longevity by interference with IGF-I/insulin sensing pathways also lead to resistance to multiple forms of stress. Here, we report that skin-derived fibroblasts from Snell dwarf mice, already known to show increased longevity and delayed aspects of aging, are resistant to multiple forms of cellular stress, including UV light, heat, paraquat, H2O2, and the toxic metal cadmium. The findings suggest that increases in cellular resistance to stress may mediate extended longevity in mammals.
Murakami
Shin
S
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Salmon
Adam
A
Miller
Richard A
RA
D000818:Animals; D002104:Cadmium / Q000633:toxicity; D004392:Dwarfism / Q000235:genetics; D005347:Fibroblasts / Q000187:drug effects / Q000528:radiation effects; D006358:Hot Temperature; D006861:Hydrogen Peroxide / Q000633:toxicity; D007928:Lethal Dose 50; D008136:Longevity / Q000235:genetics*; D051379:Mice; D008817:Mice, Mutant Strains; D008954:Models, Biological; D010269:Paraquat / Q000633:toxicity; D014466:Ultraviolet Rays
D002104:Cadmium; D006861:Hydrogen Peroxide; D010269:Paraquat