title: Comparison of multi-lineage cells from human adipose tissue and bone marrow.
abstract: Our laboratory has recently characterized a population of cells from adipose tissue, termed processed lipoaspirate (PLA) cells, which have multi-lineage potential similar to bone-marrow-derived mesenchymal stem cells (MSCs). This study is the first comparison of PLA cells and MSCs isolated from the same patient. No significant differences were observed for yield of adherent stromal cells, growth kinetics, cell senescence, multi-lineage differentiation capacity, and gene transduction efficiency. Adipose tissue is an abundant and easily procured source of PLA cells, which have a potential like MSCs for use in tissue-engineering applications and as gene delivery vehicles.
authors.affiliation: Departments of Surgery and Orthopaedics, UCLA School of Medicine, Los Angeles, California, USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: De Ugarte
authors.forename: Kouki
authors.initials: K
authors.lastname: Morizono
authors.forename: Amir
authors.initials: A
authors.lastname: Elbarbary
authors.forename: Zeni
authors.initials: Z
authors.lastname: Alfonso
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Zuk
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.forename: Jason L
authors.initials: JL
authors.lastname: Dragoo
authors.forename: Peter
authors.initials: P
authors.lastname: Ashjian
authors.forename: Bert
authors.initials: B
authors.lastname: Thomas
authors.forename: Prosper
authors.initials: P
authors.lastname: Benhaim
authors.forename: Irvin
authors.initials: I
authors.lastname: Chen
authors.forename: John
authors.initials: J
authors.lastname: Fraser
authors.forename: Marc H
authors.initials: MH
authors.lastname: Hedrick
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells / Q000166:cytology*; D002455:Cell Division / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology*; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000502:physiology; D002648:Child; D005260:Female; D018014:Gene Transfer Techniques; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D008875:Middle Aged; D023822:Tissue Engineering