title: [Immunological synapses and neuronal synapses].
abstract: The interface between two cells from the immune system has recently been coined "immunological synapse". The authors review recent findings concerning the structure of the synapse formed between T lymphocytes and antigen-presenting cells. T cells can be part of different synapses, depending on the antigen-presenting cell (B cell hybridoma, proteo-lipid bilayer, macrophage, dendritic cell). The synapse formed with dendritic cells is discussed in more details. A comparison is made with the synapses from the nervous system. Several parallel questions are discussed: how receptors can be clustered, what is the influence of synapse functioning on the structure of the synapse. It is suggested that in both cases two modes of communication exist in parallel: direct cell-cell contacts and soluble mediators, neurotransmitters in one case, putative immunotransmitters in the other.
authors.affiliation: Département de Biologie Cellulaire, Institut Cochin, Inserm U.567, Cnrs UMR 8104, 22, rue Méchain, 75014 Paris, France. trautmann@cochin.inserm.fr
authors.forename: Alain
authors.initials: A
authors.lastname: Trautmann
authors.forename: Patrick
authors.initials: P
authors.lastname: Revy
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Donnadieu
authors.forename: Georges
authors.initials: G
authors.lastname: Bismuth
mesh_terms: D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism; D002490:Central Nervous System / Q000502:physiology; D003712:Dendrites / Q000502:physiology; D006801:Humans; D018377:Neurotransmitter Agents / Q000276:immunology / Q000502:physiology; D015398:Signal Transduction; D013569:Synapses / Q000276:immunology* / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D018377:Neurotransmitter Agents