title: [Invasive infection with Moraxella catarrhalis in two children with lymphatic leukemia and granulocytopenia].
abstract: In two young children with leukaemia, a girl and a boy aged 5 and 4 years, respectively, an invasive infection due to Moraxella catarrhalis was diagnosed at the time of granulocytopenia. They were treated with antibiotics. The first child developed pneumonia and recovered, the other developed severe septic shock and died. M. catarrhalis is a Gram-negative diplococcus, frequently colonising the upper respiratory tract in young children. In childhood this pathogen mainly causes infections such as otitis media and sinusitis, while in adults it primarily causes laryngitis, bronchitis and pneumonia. Immunocompromised patients or patients with chronic cardiopulmonary disease have an increased risk of severe infections.
authors.affiliation: Afd. Algemene Kindergeneeskunde en Infectieziekten, Universitair Medisch Centrum Utrecht, Wilhelmina Kinderziekenhuis, Postbus 85.090, 3508 AB Utrecht.
authors.forename: M R
authors.initials: MR
authors.lastname: Ernst-Kruis
authors.forename: M I
authors.initials: MI
authors.lastname: Rutgers
authors.forename: T
authors.initials: T
authors.lastname: Révész
authors.forename: T F
authors.initials: TF
authors.lastname: Wolfs
authors.forename: A
authors.initials: A
authors.lastname: Fleer
authors.forename: S P
authors.initials: SP
authors.lastname: Geelen
mesh_terms: D000380:Agranulocytosis / Q000150:complications* / Q000276:immunology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D008297:Male; D001936:Moraxella catarrhalis / Q000472:pathogenicity*; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D012772:Shock, Septic / Q000188:drug therapy / Q000209:etiology / Q000276:immunology
chemical_list: D000900:Anti-Bacterial Agents