Animal models of spinal cord injury pain and their implications for pharmacological treatments.
Patients with spinal cord injury often develop chronic pain syndrome, which is difficult to treat. Several animal models of spinal cord injury have been developed in recent years which have significantly advanced our understandings of pathophysiology of this condition. This paper reviews some recent data in the pharmacological treatment of spinal cord injury pain using animal models, and discusses possible clinical applications.
Hao
Jing-Xia
JX
Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden.
Xu
Xiao-Jun
XJ
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D023421:Models, Animal; D009294:Narcotics / Q000494:pharmacology; D009569:Nitric Oxide / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D010146:Pain / Q000188:drug therapy; D016194:Receptors, N-Methyl-D-Aspartate / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D026941:Sodium Channel Blockers / Q000494:pharmacology; D013119:Spinal Cord Injuries / Q000188:drug therapy*
D000700:Analgesics; D000927:Anticonvulsants; D009294:Narcotics; D016194:Receptors, N-Methyl-D-Aspartate; D026941:Sodium Channel Blockers; D009569:Nitric Oxide