A CD40 bridge between innate and adaptive immunity.
In this issue of Immunity, Brodeur et al. show that C4b binding protein (C4BP), a regulator component of the classical complement (C) pathway, can bind to CD40 receptors on B cells and activate them. This suggests a novel way by which CD40 may function to bridge innate and adaptive immune responses.
Clark
Edward A
EA
Department of Microbiology, Box 357242, University of Washington, Seattle, WA 98195, USA.
Craxton
Andrew
A
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D019013:CD40 Antigens / Q000276:immunology*; D003169:Complement Inactivator Proteins / Q000378:metabolism; D006023:Glycoproteins; D006801:Humans; D007113:Immunity, Innate; D011956:Receptors, Cell Surface / Q000378:metabolism
D019013:CD40 Antigens; D003169:Complement Inactivator Proteins; D006023:Glycoproteins; D011956:Receptors, Cell Surface