title: [Integer multiple rhythm in the spontaneous beating rhythm of cardiac myocytes and its possible mechanism].
abstract: OBJECTIVE
  To introduce the characteristics of the integer multiple rhythm of cultured cardiac myocytes and to explore the cause of its generation.
  
  
  METHODS
  Spontaneous beating rhythms of cultured cardiac myocytes were observed with photometry system and stochastic Chay model was used to simulate the experimental results.
  
  
  RESULTS
  Integer multiple rhythm was observed in the experiment. This kind of rhythm is similar to phenomena of sinus arrest. The integer multiple rhythm similar to that of the experiments was simulated in stochastic Chay model, and was demonstrated to be induced by the mechanism of autonomous stochastic resonance.
  
  
  CONCLUSIONS
  The integer multiple rhythm observed in the experiment might be generated via the effect of autonomous stochastic resonance.
authors.affiliation: Institute of Space Medico-Engineering, Beijing, China.
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Hua-guang
authors.initials: HG
authors.lastname: Gu
authors.forename: Ming-hao
authors.initials: MH
authors.lastname: Yang
authors.forename: Fen
authors.initials: F
authors.lastname: Yang
authors.forename: Shao-guang
authors.initials: SG
authors.lastname: Fan
authors.forename: Wei
authors.initials: W
authors.lastname: Ren
mesh_terms: D000200:Action Potentials; D000818:Animals; D002478:Cells, Cultured; D008954:Models, Biological; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000166:cytology*; D032383:Myocytes, Cardiac / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar; D013269:Stochastic Processes