[Evaluation of lipids, lipoproteins and apolipoproteins in the blood serum of children with type 1 diabetes].
BACKGROUND
Children and youth with type 1 diabetes have a higher risk of atherosclerosis. Therefore all of the atherosclerosis risk factors should be observed in those children early. The disorders of lipid metabolism are characteristic and their intensification depends on the type of diabetes and its balance.


OBJECTIVE
The objective of the paper was to evaluate behaviour of lipids, lipoproteins and apolipoproteins behaviour in the blood serum of children with type 1 diabetes.


METHODS
The study included 53 children (23 girls and 30 boys) with type 1 diabetes aged 8-16 years suffering from diabetes for 3-10 years. During the study the children were in the state of relative metabolic balance. In all of the studied subjects concentration of triglycerides, total and HDL cholesterol, apolipoproteins (Apo-AI, Apo-B) were assayed in the blood serum. The level of LDL and VLDL cholesterol was determined with an indirect method. The obtained results were statistically analysed and compared with the earlier developed own standards for the healthy children.


RESULTS
In the girls with type 1 diabetes higher levels of triglycerides and of total cholesterol, LDL and VLDL cholesterol as well as of Apo-B were confirmed and a lower level of HDL cholesterol was noticed as compared with the control group. But in the boys with type 1 diabetes higher level of LDL cholesterol and lower level of HDL cholesterol were confirmed as compared with the healthy children.


CONCLUSIONS
1) In the children and youth with type 1 diabetes the disorders of lipid metabolism were confirmed. 2) Periodical evaluation of lipid metabolism should be taken into account in monitoring children with type 1 diabetes.
Pac-Kozuchowska
Elzbieta
E
Szewczyk
Leszek
L
Witkowski
Daniel
D