Amoxicillin-induced nephritis and tubulitis in a child.
The occurrence of interstitial nephritis in patients receiving antimicrobial therapy has frequently been reported in adults while it has rarely been described in children. We report the case of a patient treated with amoxicillin who presented hallucinations and serosanguineous blisters during treatment and developed renal failure a few days after discontinuation of the drug. On renal biopsy an interstitial nephritis with tubulitis was identified.
Ferrara
Pietro
P
Department of Pediatrics, Catholic University, A. Gemelli Hospital, Rome, Italy. pietro.ferrara@mailcity.com
D'Aleo
Carmen M
CM
Rigante
Donato
D
Paolini Paoletti
Fabrizia
F
Zannoni
Gianfranco
G
Venuti
Laura
L
Fundarò
Carlo
C
Rendeli
Claudia
C
Salvaggio
Elio
E
D000208:Acute Disease; D058186:Acute Kidney Injury / Q000188:drug therapy / Q000209:etiology; D000658:Amoxicillin / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D002648:Child; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D010406:Penicillins / Q000009:adverse effects*; D011241:Prednisone / Q000627:therapeutic use; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D010406:Penicillins; D000658:Amoxicillin; D011241:Prednisone