[Studies on 2-hydroxyestradiol 17-sulfate derived from fetoplacental unit: the antioxidant as a potential defense substance against preeclampsia].
The antioxidant 2-hydroxyestradiol 17-sulfate (2-OH-E2-17-S) was found to be present in the placenta and to prevent the onset of preeclampsia. From experiments using rats, 2-OH-E2-17-S was confirmed to be a highly functional compound with stronger antioxidant activity than alpha-tocopherol and to sustain its antioxidant activity. 2-OH-E2-17-S was confirmed to be produced in the placenta from its precursor, estradiol 17-sulfate (E2-17-S), which is derived from fetal testosterone sulfate (TS). Since the fetal adrenal gland has been shown to convert testosterone (T) into TS, the following metabolic pathway may exist during pregnancy: T-->TS-->E2-17-S-->2-OH-E2-17-S. This fetoplacental pathway may contribute to the maintenance of healthy pregnancy. Details and the experimental outline of these discoveries are reported in this review.
Takanashi
Kaori
K
Laboratory of Pharmaceutical Analysis, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru 047-0264, Japan. kaori-kt@hokuyakudai.ac.jp
D000818:Animals; D000975:Antioxidants; D002396:Catechols / Q000097:blood; D004958:Estradiol / Q000031:analogs & derivatives* / Q000096:biosynthesis* / Q000097:blood / Q000502:physiology* / Q000652:urine; D005260:Female; D006801:Humans; D006900:Hydroxylation; D015227:Lipid Peroxidation; D008862:Microsomes, Liver / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000209:etiology / Q000517:prevention & control*; D011247:Pregnancy; D051381:Rats
D000975:Antioxidants; D002396:Catechols; C048615:estradiol 17-sulfate; D004958:Estradiol; C060524:2-hydroxyestradiol 17-sulfate