Pulse therapy with 5-FU in eradicating actinic keratoses with less than recommended dosage.
Pulse therapy has been used for many years, but rarely in a clinical setting. This article describes a clinical study designed to determine the efficacy of pulse therapy with 5-FU for patients with multiple actinic keratoses. The results indicated that pulse therapy was indeed effective in eradicating most of the actinic keratoses while causing less discomfort or disfigurement than the FDA recommended dose, especially for patients with less severe and milder forms of actinic keratoses.
Robins
Perry
P
New York University Medical Center, 530 First Avenue, New York, NY 10016, USA. doctorrobins@yahoo.com
D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007642:Keratosis / Q000145:classification / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D020551:Pulse Therapy, Drug / Q000379:methods; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil