title: Chromosome alterations in cleanup workers sampled years after the Chernobyl accident.
abstract: Cytogenetic analysis performed 4-13 years after the Chernobyl accident showed an elevated frequency of acentrics, chromatid exchanges, dicentrics and rings in Chernobyl cleanup workers compared to the control group. Cytogenetic data were analyzed according to the information on exposure to radiation (the year when the cleanup workers worked at the Chernobyl station, doses rates, time elapsed since exposure to radiation, and cytogenetic examination) and some lifestyle factors. The data obtained suggested that some types of chromosome aberrations could be influenced by the action of different environmental factors or lifestyle factors. The frequency of acentrics was correlated with the age of the cleanup workers, and the increased chromatid exchange frequency was attributed to smoking. The numbers of dicentrics and rings suggested a genotoxic effect of ionizing radiation that is still present over 13 years after the exposure.
authors.affiliation: All Russian Centre of Emergency and Radiation Medicine, Laboratory of Biodosimetry and Clinical Cytogenetics, EMERCOM of Russia, St. Petersburg, Russia. cytogen@arcerm.spb.ru
authors.forename: Elizaveta
authors.initials: E
authors.lastname: Neronova
authors.forename: Natalia
authors.initials: N
authors.lastname: Slozina
authors.forename: Alexey
authors.initials: A
authors.lastname: Nikiforov
mesh_terms: D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D015331:Cohort Studies; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D016273:Occupational Exposure; D011210:Power Plants; D011839:Radiation, Ionizing; D018788:Radioactive Hazard Release; D013997:Time Factors; D014455:Ukraine