Platelet fibrinogen in the patients with idiopathic bleeding platelet disorder.
The changes of platelet fibrinogen in patients with obscure cutaneous mucosal bleeding and their relation with disease were evaluated. By using flow cytometry and Western blot, the platelet binding site of fibrinogen and the expression of platelet fibrinogen in 8 cases of obscure bleeding were detected. The results showed that platelet surface binding sites of fibrinogen were 65.38 +/- 3.62 in the resting state and 65.25 +/- 5.78 after activated by adenosine diphosphate, showing no significant difference as compared with control group (P > 0.05). The expression of platelet fibrinogen was obviously decreased in 4 patients and increased in one case as compared with control group. It was concluded that the binding sites of fibrinogen on the platelet surface were normal in the patients with idiopathic bleeding platelet disorder. The abnormal of platelet fibrinogen might be one of hemorrhagic reasons in partial patients.
Yang
L
L
Institute of Hematology, Tongji Medical University, Wuhan 430022.
Shen
D
D
Wang
A
A
Wei
W
W
Liu
Z
Z
Yang
R
R
Yang
Y
Y
Zhang
Y
Y
D000328:Adult; D001665:Binding Sites; D001791:Blood Platelet Disorders / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D005434:Flow Cytometry; D006470:Hemorrhage / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D039341:Receptors, Fibrinogen / Q000378:metabolism
D039341:Receptors, Fibrinogen; D005340:Fibrinogen