Combined effects of cyclosporin and nifedipine on gingival overgrowth in rats is not age dependent.
BACKGROUND
Cyclosporin A and nifedipine cause gingival overgrowth in rat, and the combined use of these drugs increases the overgrowth severity.


OBJECTIVE
The purpose of this study was to compare gingival overgrowth of rats of differents ages treated with cyclosporin A and nifedipine alone or given concurrently.


METHODS
Rats 15, 30, 60 and 90 d old were treated with 10 mg/kg body weight of cyclosporin A and/or 50 mg/kg body weight of nifedipine in the chow.


RESULTS
Young rats showed evident gingival overgrowth with nifedipine, cyclosporin A, and cyclosporin A and nifedipine given concurrently. Adult rats did not show significant gingival alterations when treated with cyclosporin A and nifedipine alone. Nevertheless evident gingival overgrowth with alterations of the epithelium and connective tissue were observed when treated simultaneously with cyclosporin A and nifedipine.


CONCLUSIONS
These results suggest that the combined effects of cyclosporin A and nifedipine on gingival overgrowth in rat is not age dependent.
Spolidorio
L C
LC
Department of Oral Pathology and Periodontology, Dental School, Araraquara, University of State of São Paulo, São Paulo, Brazil. lcs@foar.unesp.br
Spolidorio
D M
DM
Benatti
C
C
Sampaio
J E
JE
Almeida
O P
OP
D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000009:adverse effects*; D003238:Connective Tissue / Q000187:drug effects; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations; D004357:Drug Synergism; D004848:Epithelium / Q000187:drug effects; D019214:Gingival Overgrowth / Q000139:chemically induced*; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar
D002121:Calcium Channel Blockers; D004338:Drug Combinations; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009543:Nifedipine