Heat stability of the lyophilized Sabin poliovaccine.
In this study we lyophilized three types of live attenuated polioviruses (Sabin vaccine strains) and evaluated the lyophilized vaccine viruses' heat stability. The virus titers were measured after heating at 37  and 45  and then compared with the titers of conventional liquid vaccine viruses similarly treated. The results showed that lyophilization, while slightly reducing vaccine virus titers, had a far greater sparing effect on subsequent heat inactivation of lyophilized vaccine viruses, thus demonstrating its validity for the improvement of the vaccine.
Shiomi
Hiroshi
H
Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan. urasawa@fujijoshi.ac.jp
Urasawa
Tomoko
T
Urasawa
Shozo
S
D004355:Drug Stability; D005612:Freeze Drying; D006358:Hot Temperature; D006801:Humans; D011055:Poliovirus Vaccine, Oral / Q000737:chemistry*
D011055:Poliovirus Vaccine, Oral