title: Synthesis and antibacterial activity of oxazolidinone containing sulphonyl group.
abstract: A series of oxazolidinone derivatives carrying sulphonyl group was synthesized and their antibacterial activity was evaluated in vitro. Many of such compounds demonstrated potent antibacterial activity. The activity of a novel compound (YC-20) was 2-4-fold more potent than that of linezolid.
authors.affiliation: Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences, 200031, Shanghai, China.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Cui
authors.forename: Yushe
authors.initials: Y
authors.lastname: Yang
authors.forename: Kaixian
authors.initials: K
authors.lastname: Chen
authors.forename: Ruyun
authors.initials: R
authors.lastname: Ji
authors.forename: Shuhua
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006094:Gram-Positive Bacteria / Q000187:drug effects; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D023303:Oxazolidinones / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D010080:Oxazoles; D023303:Oxazolidinones; D013449:Sulfonamides; D000069349:Linezolid