Protein kinase D: a family affair.
The protein kinase D family of enzymes consists of three isoforms: PKD1/PKCmu PKD2 and PKD3/PKCnu. They all share a similar architecture with regulatory sub-domains that play specific roles in the activation, translocation and function of the enzymes. The PKD enzymes have recently been implicated in very diverse cellular functions, including Golgi organization and plasma membrane directed transport, metastasis, immune responses, apoptosis and cell proliferation.
Rykx
An
A
Division of Biochemistry, Faculty of Medicine, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium.
De Kimpe
Line
L
Mikhalap
Svetlana
S
Vantus
Tibor
T
Seufferlein
Thomas
T
Vandenheede
Jackie R
JR
Van Lint
Johan
J
D000818:Animals; D017209:Apoptosis; D001692:Biological Transport; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D004789:Enzyme Activation; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D011493:Protein Kinase C / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D007527:Isoenzymes; C089212:protein kinase D; D011493:Protein Kinase C