Modulation of DNA-mediated hole transport efficiency by DNA-protein complex formation.
To investigate how protein interactions to DNA affects DNA-mediated hole transport, hole transport through the DNA bound to restriction endonuclease BamHI was examined. The DNA bound to BamHI retains a regular B-DNA type of conformation, but have a number of hydrogen bonding interaction. These hydrogen bondings in BamHI-DNA complex suppressed the guanine oxidation and the hole transport in sequence selective manner.
Dohno
C
C
Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606-8501, Japan.
Nakatani
K
K
Saito
I
I
D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D015245:Deoxyribonuclease BamHI / Q000737:chemistry* / Q000378:metabolism; D006860:Hydrogen Bonding; D017136:Ion Transport; D046911:Macromolecular Substances
D004268:DNA-Binding Proteins; D046911:Macromolecular Substances; D004247:DNA; D015245:Deoxyribonuclease BamHI