Effects of antidepressant drugs and GR 205171, an neurokinin-1 (NK1) receptor antagonist, on the response in the forced swim test and on monoamine extracellular levels in the frontal cortex of the mouse.
We tested fluoxetine, bupropion and GR 205171, a selective neurokinin-1 receptor antagonist on forced swimming test (FST) response and on levels of monoamines in frontal cortex of CD1 mice by microdialysis techniques. All drugs decreased immobility time. Fluoxetine augmented all monoamines, bupropion enhanced catecholamines, and GR 205171 was totally ineffective. Results suggest that FST response may not be related to levels of monoamines in the mouse frontal cortex.
Zocchi
Alessandro
A
GlaxoSmithKline, Psychiatry Centre of Excellence for Drug Discovery, Via Fleming 4, 37100 Verona, Italy. alessandro.a.zocchi@gsk.com
Varnier
Giorgia
G
Arban
Roberto
R
Griffante
Cristiana
C
Zanetti
Lara
L
Bettelini
Letizia
L
Marchi
Mario
M
Gerrard
Philip A
PA
Corsi
Mauro
M
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D015306:Biogenic Monoamines / Q000378:metabolism*; D016642:Bupropion / Q000494:pharmacology; D005110:Extracellular Space / Q000187:drug effects / Q000378:metabolism; D005473:Fluoxetine / Q000494:pharmacology; D007103:Immobilization; D051379:Mice; D008815:Mice, Inbred Strains; D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines / Q000494:pharmacology*; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000378:metabolism; D013550:Swimming; D013777:Tetrazoles / Q000494:pharmacology*; D013997:Time Factors
D000928:Antidepressive Agents; D015306:Biogenic Monoamines; D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines; D013777:Tetrazoles; D005473:Fluoxetine; D016642:Bupropion; C103207:vofopitant