Electroacupuncture induces the expression of Fos in rat dorsal horn via capsaicin-insensitive afferents.
Fos is expressed in rat dorsal horn neurons after electroacupuncture (E-acupuncture), but it is unclear which types of afferent fibers are involved in the expression. It is thought that the Fos expression is induced via Adelta afferents rather than C afferents, since the threshold of Adelta afferents to electrical stimulation is much lower than that of unmyelinated ones. Therefore, neonatally capsaicin treated rats lacking many C afferents were examined to clarify this. Fos expression in the dorsal horn after injection of formalin into the hindpaw was severely attenuated by neonatal capsaicin treatment. However, Fos expression after E-acupuncture to the pads of the hindpaw was unaffected by the same treatment. These results suggest that E-acupuncture induces the expression of Fos in the dorsal horn neurons via capsaicin-insensitive afferents, presumably Adelta afferents.
Uchida
Yasuyuki
Y
Department of Physiology, Kansai College of Oriental Medicine, 2-11-1 Wakaba, Kumatori, Sennan, Osaka 590-0433, Japan.
Nishigori
Ayahiko
A
Takeda
Daisuke
D
Ohshiro
Masanori
M
Ueda
Yoshihiro
Y
Ohshima
Minoru
M
Kashiba
Hitoshi
H
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D002211:Capsaicin / Q000494:pharmacology; D015671:Electroacupuncture; D005557:Formaldehyde / Q000494:pharmacology; D005727:Ganglia, Spinal / Q000187:drug effects / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects; D006614:Hindlimb / Q000187:drug effects / Q000294:innervation; D007150:Immunohistochemistry; D008297:Male; D020671:Posterior Horn Cells / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011955:Receptors, Drug / Q000378:metabolism; D050916:TRPV Cation Channels
D016760:Proto-Oncogene Proteins c-fos; D011955:Receptors, Drug; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; D005557:Formaldehyde; D002211:Capsaicin