title: [A case-control study on the vitamin D receptor gene polymorphisms and susceptibility to pulmonary tuberculosis].
abstract: OBJECTIVE
  To investigate the association between the genetic polymorphisms of VDR gene and susceptibility to pulmonary tuberculosis.
  
  
  METHODS
  Case-control study was conducted. PCR-RFLP technique was used to detect the C/T polymorphism in VDR gene. Information on related factors of tuberculosis was collected using a pre-tested questionnaire. Univariate and multivariate logistic analyses were conducted with SPSS software package.
  
  
  RESULTS
  A sample of 76 cases and 171 controls was studied. The genotype frequencies of VDR-FF, VDR-Ff and VDR-ff were 38.2%, 44.7%, 17.1% and 52.6%, 40.9%, 6.4% respectively. VDR-ff was significantly overrepresented in case group, the OR (95% CI) was 3.668 (1.483 - 9.071) when comparing with FF genotype. The significant association remained after adjusting BCG immunization and smoking, the OR (95% CI) was 3.036 (1.117 - 8.253).
  
  
  CONCLUSIONS
  The VDR-ff genotype might be associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.
authors.affiliation: Epidemiological Department of Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Cui-ying
authors.initials: CY
authors.lastname: Zhang
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Wu
authors.forename: Lei
authors.initials: L
authors.lastname: Tian
authors.forename: Chun-zhi
authors.initials: CZ
authors.lastname: Li
authors.forename: Qiu-min
authors.initials: QM
authors.lastname: Zhao
authors.forename: Pan-he
authors.initials: PH
authors.lastname: Zhang
authors.forename: Shu-mei
authors.initials: SM
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Xi-tan
authors.initials: XT
authors.lastname: Zhang
authors.forename: Wu-chun
authors.initials: WC
authors.lastname: Cao
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol