Radiation and malformations in a murine model.
Thus, the results of radiation exposure of the different stages of spermatogenesis with regard to the induction of malformations in the offspring of these exposed male mice can be summarized as follows: It is possible to induce malformations in the offspring by radiation exposure of male mice of the HLG strain. This means that direct DNA damage is responsible for the induction of the observed malformations. The highest sensitivity is observed during meiosis. The fact that direct DNA damage is involved in the induction of radiation induced malformations underlines the hypothesis mentioned above, that two processes may have a major impact on malformation induction in germ cells and preimplantation stages: 'genetic predisposition' and 'genomic instability'.
Müller
Wolfgang U
WU
Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, D45122 Essen, Germany. wolfgang.ulrich.mueller@uni.essen.de
D000016:Abnormalities, Radiation-Induced; D000818:Animals; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005720:Gamma Rays; D008297:Male; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal; D013091:Spermatogenesis / Q000528:radiation effects*; D013094:Spermatozoa / Q000528:radiation effects*; D013997:Time Factors