Effect of purified collagen on lipograft survival: experimental basis for periurethral lipoinjections.
OBJECTIVE
To assess whether the use of collagens with lipografts improves graft survival.


METHODS
Thirty isogenic New Zealand rabbits were injected in the auricular area with either autologous fat alone or autologous fat associated with collagen. The animals were evaluated at 7, 30, and 90 days by histologic and morphometric methods together with measurements of the graft area and the number of adipocytes.


RESULTS
Addition of collagen to the lipoinjection reduced the local inflammatory reaction and improved the graft's survival; e.g., for stress urinary incontinence.


CONCLUSIONS
These results suggest that it is possible to increase the survival rate of the lipografts and improve their clinical applicability.
Palma
Paulo César Rodrigues
PC
Department of Urology, Faculty of Medical Sciences, State University of Campinas, UNICAMP, Campinas, São Paulo, Brazil.
Vidal
Benedicto
B
Riccetto
Cássio Luís Zanettini
CL
Herrmann
Viviane
V
Dambros
Míriam
M
Thiel
Marcelo
M
Netto
Nelson Rodrigues
NR
D017667:Adipocytes / Q000378:metabolism*; D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism / Q000637:transplantation*; D000818:Animals; D003094:Collagen / Q000008:administration & dosage*; D006085:Graft Survival; D007267:Injections; D015187:Lipectomy; D011817:Rabbits; D011897:Random Allocation
D003094:Collagen