[Diagnosis of parvovirus B19 infection in patients with secondary immunodeficiency diseases].
The method of immune-enzyme assay was used to examine 113 patients with secondary immunodeficiency, including 16 HIV-infected drug-addicts (group 1), 36 patients with cytomegalovirus infection (CMVI) and with immunoregating index CD4/CD8 below 1.0 (group 2), 30 patients with CMVI and with CD4/CD8 below 1.2 (group 3) and 31 patients with aplastic anemia and with anemia of unclear genesis (group 4), for parvovirus infection caused by parvovirus B19. As for groups 1 and 4, the antibodies were detected in 50 and 48.4% of cases; it is noteworthy that an active parvovirus infection was registered in the above groups more often than in groups 2 and 3. There were patients with the antibodies in group 2 by 1.8 times more than in group 3. It is suggested that the simultaneous impact of HIV, CMV and parvoviruses significantly aggravates the immunodeficiency and contributes to a more severe clinical course.
Dolgikh
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TI
Nazarova
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OI
D000914:Antibodies, Viral / Q000097:blood; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D010321:Parvoviridae / Q000276:immunology; D010322:Parvoviridae Infections / Q000175:diagnosis* / Q000821:virology
D000914:Antibodies, Viral