Vaccination: a future modality of cancer therapy.
With an expanding list of known tumor antigens and increasing knowledge of the requirements for activation of immune effector functions, immunotherapy of cancer is about to become the fourth weapon in the fight against cancer, together with surgery, radiation and chemotherapy. Although our knowledge has come mostly from experimental models, the mechanistic premises observed in these models will provide a reasonable basis for immunotherapeutic protocols in cancer patients.
Zoller
M
M
Department of Tumor Progression and Immune Defense, German Cancer Research Center, Heidelberg, Germany.
Matzku
S
S