The prognostic value of p53 and DNA ploidy following radical prostatectomy.
This study assesses the correlation of p53 immunoreactivity and DNA ploidy status with biochemical recurrence after radical prostatectomy. p53 protein expression and DNA ploidy were evaluated on 84 archival paraffin-embedded radical prostatectomy specimens. Patients were divided into two groups: those with low (38/84, 45%) and those with high (46/84, 55%) p53 immunoreactivity. The results were correlated with Gleason score, stage and serum PSA. Kaplan-Meier biochemical recurrence free survival and the Cox hazard-regression model were used for analysis. Multivariate analysis revealed p53, DNA ploidy, Gleason score, PSA and stage to be independent prognostic factors in this order. Kaplan-Meier analysis showed a significant difference in biochemical recurrence when p53 high expression and DNA aneuploidy were combined. The results of this study suggest that stratification for p53 expression and DNA ploidy status can provide additional prognostic information for patients with prostate carcinoma after radical prostatectomy.
Deliveliotis
C
C
University of Athens, Sismanoglio Hospital, Athens. Greece. nikistra@hol.gr
Skolarikos
A
A
Karayannis
A
A
Tzelepis
V
V
Trakas
N
N
Alargof
E
E
Protogerou
V
V
D000368:Aged; D004273:DNA, Neoplasm / Q000235:genetics*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D011379:Prognosis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000276:immunology* / Q000601:surgery; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000276:immunology*
D004273:DNA, Neoplasm; D016159:Tumor Suppressor Protein p53