Skeletal myogenesis in the mouse esophagus does not occur through transdifferentiation.
To determine the developmental history of murine esophageal skeletal muscle, smooth muscle cells were fate mapped by lineage-specific recombination and phenotypically marked by eGFP. Examination of embryonic and postnatal tissues revealed that esophageal skeletal muscle does not arise from transdifferentiation of committed smooth muscle cells.
Rishniw
Mark
M
Xin
Hong-Bo
HB
Deng
Ke-Yu
KY
Kotlikoff
Michael I
MI
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D004947:Esophagus / Q000166:cytology / Q000196:embryology* / Q000254:growth & development*; D049452:Green Fluorescent Proteins; D008164:Luminescent Proteins / Q000235:genetics; D008297:Male; D051379:Mice; D008856:Microscopy, Fluorescence; D018482:Muscle, Skeletal / Q000166:cytology / Q000196:embryology* / Q000254:growth & development*
D008164:Luminescent Proteins; D049452:Green Fluorescent Proteins