title: [Small pox--infection, therapy and anaesthesiological management (part 1)].
abstract: Smallpox is an acute contagious and sometimes fatal infectious disease. It is caused by the variola-virus. Smallpox is characterized by a typical disease form with a progressive distinctive skin rash, especially at face, arms and legs. Smallpox has a fatality rate of about 30 % and the therapy of infected patients is only symptomatically. As prevention the WHO initiated worldwide vaccination programs in the year 1967. The last naturally occurring case of smallpox in the world was in Somalia in 1977. Since then the only known cases of smallpox happened from an outbreak in Birmingham, England caused by a laboratory accident in the year of 1979. On May the 8 th 1980 the disease was declared as eliminated from the world by the WHO (WHO-Resolution 33.33). A natural occurrence of the variola-virus seems to be not given. Nevertheless the virus exists for research in two laboratories, the American Centers of Disease Control and Prevention in Atlanta, Georgia and in the Russian Research Center for Virology and Biotechnics in Kolzowo, Sibiria. Threatening infections with smallpox or other microorganisms, used as bioweapons, get a new dimension through global terrorism. The variola-virus represents an optimal candidate for bioweapons. It is easy to replicate, it is highly contagious and the transmission over aerosol or direct contact from man to man is easy to handle. After the disease was eliminated from the world, routine vaccination among general public was stopped. Therefore younger people don't possess any vaccination protection. Older formerly vaccinated people probably have only a non-sufficient protection. Because of the smallpox elimination a lot of physicians have no experience with this disease. An outbreak of this smallpox isn't only controlled by new vaccination. In our times we need adapted prevention-standards, pox-alarm plans and quarantine standards.
authors.affiliation: Abteilung für Anaesthesiologie, Intensivmedizin und Schmerztherapie Universitätsklinikum Giessen. t_langefeld@yahoo.de
authors.forename: T W
authors.initials: TW
authors.lastname: Langefeld
authors.forename: J
authors.initials: J
authors.lastname: Engel
authors.forename: T
authors.initials: T
authors.lastname: Menges
authors.forename: G
authors.initials: G
authors.lastname: Hempelmann
mesh_terms: D000758:Anesthesia / Q000379:methods*; D023482:Bioterrorism; D002487:Centers for Disease Control and Prevention, U.S.; D018450:Disease Progression; D006801:Humans; D012899:Smallpox / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy* / Q000635:transmission*; D012900:Smallpox Vaccine; D014481:United States; D014944:World Health Organization
chemical_list: D012900:Smallpox Vaccine