title: Evaluating dose regimens of apomorphine, an open-label study.
abstract: The aim of the study was to investigate the safety and efficacy of apomorphine SL (apo SL) 2 and 3 mg, using a dose-optimisation regime in 110 Asian men with erectile dysfunction (ED) during a 10-week open-label study. Based on daily diaries kept by each patient, 63% showed an improvement in their sexual life. Patient responses to the International Index for Erection Function 15 questionnaires showed that there was an improvement in erectile function from baseline score after treatment with apo SL (from 15.9 to 20.4), and intercourse satisfaction (from 7.7 to 9.9), as well as slight improvements in orgasmic function (from 6.8 to 7.5) and total satisfaction (from 41.9 to 50.8). There was no marked improvement seen in sexual desire. In conclusion, apo SL is safe and efficacious in the treatment of ED in this patient population, irrespective of underlying diseases and concomitant medications.
authors.affiliation: Division of Urology, Department of Surgery, Chulalongkorn University Hospital, Bangkok, Thailand. apichat.k@chula.ac.th
authors.forename: A
authors.initials: A
authors.lastname: Kongkanand
authors.forename: J
authors.initials: J
authors.lastname: Opanuraks
authors.forename: K
authors.initials: K
authors.lastname: Tantiwongse
authors.forename: N
authors.initials: N
authors.lastname: Choeypunt
authors.forename: A
authors.initials: A
authors.lastname: Tantiwong
authors.forename: T
authors.initials: T
authors.lastname: Amornvejsukit
mesh_terms: D001058:Apomorphine / Q000008:administration & dosage* / Q000009:adverse effects; D018491:Dopamine Agonists / Q000008:administration & dosage* / Q000009:adverse effects; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D017060:Patient Satisfaction; D013785:Thailand
chemical_list: D018491:Dopamine Agonists; D001058:Apomorphine