title: Comparative study of the natural history and operative outcome in patients 75 years and older with thoracic aortic aneurysm.
abstract: Surgery for thoracic aortic aneurysm (TAA) in patients 75 years and older is a high risk, but data for their natural history are not available. In the present study the subjects were 62 patients with TAA aged on average 78 years (range, 75-85 years) enrolled between August 1994 and December 2001: 20 operatively treated patients (OPE) and 42 medically managed patients (MED). All of them had been included in the indication for TAA surgery at the time of consultation. Hospital mortality rates and survival rates (Kaplan-Meier method) were compared among emergency OPE, elective OPE, and MED. There were 136 total patient-years of follow-up. Actuarial survival in MED (ie, the natural history) was 83% at 1 year after consultation and 41% at 3 years. Hospital mortality rates in emergency and elective OPE were 27% (3/11) and 0% (0/9), respectively (p=0.22), and the corresponding 3-year survival rates were 44% and 83% (p=0.019). Actuarial survival in elective OPE was higher than that in MED (p=0.022), but that of emergency OPE was similar to that for MED (p=0.17). Patients aged 75 years and older with TAA should undergo an elective operation if the aneurysm diameter is larger than 6 cm and if the patient is asymptomatic and in good anatomicosurgical, physical, and social condition.
authors.affiliation: Department of Cardiovascular Surgery, Clinical Research Institute, National Kyushu Medical Center, Fukuoka, Japan. kawachiy@qmed.hosp.go.jp
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Kawachi
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Nakashima
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Kosuga
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoeda
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Toshima
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nishimura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017542:Aneurysm, Ruptured / Q000601:surgery; D017545:Aortic Aneurysm, Thoracic / Q000188:drug therapy / Q000503:physiopathology* / Q000601:surgery*; D004632:Emergency Medical Services; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D016019:Survival Analysis; D016896:Treatment Outcome