title: Change in mammographic breast density associated with the use of Depo-Provera.
abstract: We report two cases in which routine mammograms showed a significant increase in breast density compared to previous studies. Review of patient histories revealed that both women had been receiving contraceptive injections of Depo-Provera at the time of their earlier mammograms. Breast density increased after Depo-Provera was discontinued. We postulate that Depo-Provera has a suppressive effect on breast density. Alterations in breast density may have implications regarding breast cancer risk. Etiologies of generalized change in breast density are reviewed.
authors.affiliation: Department of Radiology, West Virginia University School of Medicine, Morgantown, West Virginia 26507, USA. cdillis@hsc.wvu.edu
authors.forename: Charlotte L
authors.initials: CL
authors.lastname: Dillis
authors.forename: Judith S
authors.initials: JS
authors.lastname: Schreiman
mesh_terms: D000328:Adult; D001940:Breast / Q000187:drug effects* / Q000473:pathology; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008327:Mammography; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D045167:Progesterone Congeners / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D003271:Contraceptive Agents, Female; D045167:Progesterone Congeners; D017258:Medroxyprogesterone Acetate