title: Synthesis and biological testing of non-fluorinated analogues of levofloxacin.
abstract: Quinolones without the usual 6-fluorine substituent have been recently described as potent antibacterial agents. A series of non-fluorinated analogues of the antibacterial quinolone Levofloxacin were synthesized and tested.
authors.affiliation: Procter & Gamble Pharmaceuticals, 8700Mason-Montgomery Rd, 45040, Mason, OH, USA. gray.jl.2@pg.com
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Gray
authors.forename: Ji In K
authors.initials: JI
authors.lastname: Almstead
authors.forename: Corey P
authors.initials: CP
authors.lastname: Gallagher
authors.forename: X Eric
authors.initials: XE
authors.lastname: Hu
authors.forename: Nick K
authors.initials: NK
authors.lastname: Kim
authors.forename: Cynthia J
authors.initials: CJ
authors.lastname: Taylor
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Twinem
authors.forename: Cynthia D
authors.initials: CD
authors.lastname: Wallace
authors.forename: Benoit
authors.initials: B
authors.lastname: Ledoussal
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015242:Ofloxacin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors
chemical_list: D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D059005:Topoisomerase II Inhibitors; D064704:Levofloxacin; D015242:Ofloxacin