Physiological evaluation of a rabbit kidney perfused with VS41A.
The current report compares the renal physiological impact of a standard vitrification solution, VS41A, as measured by normothermic blood perfusion, to the physiological effects of VS4, a related but more dilute vitrification solution previously shown to be consistently compatible with life support function of transplanted rabbit kidneys. VS41A, which allows survival of only about half of the kidneys perfused with it, also appeared to be more damaging than VS4 based on in vitro functional indices and histology in one rabbit kidney so evaluated.
Arnaud
Françoise G
FG
Naval Medical Research Center, Combat Casualty Care, Resuscitative Medicine Program 503 R. Grant Ave, Silver Spring, MD 20910-7500, USA.
Khirabadi
Bijan
B
Fahy
Gregory M
GM
D000042:Absorption / Q000187:drug effects; D000818:Animals; D001769:Blood; D003404:Creatinine / Q000097:blood; D003451:Cryoprotective Agents / Q000009:adverse effects / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000009:adverse effects / Q000494:pharmacology*; D005559:Formamides / Q000009:adverse effects / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006531:HEPES / Q000009:adverse effects / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology*; D016030:Kidney Transplantation; D010477:Perfusion; D011409:Propylene Glycols / Q000009:adverse effects / Q000494:pharmacology*; D011817:Rabbits; D012079:Renal Circulation / Q000187:drug effects; D012964:Sodium / Q000378:metabolism; D013696:Temperature; D014022:Tissue Survival / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D003451:Cryoprotective Agents; D005559:Formamides; D011409:Propylene Glycols; C481729:VS55 solution; D012964:Sodium; D003404:Creatinine; D006531:HEPES; D004121:Dimethyl Sulfoxide