title: Six-year follow-up of laser in situ keratomileusis for moderate and extreme myopia using a first-generation excimer laser and microkeratome.
abstract: OBJECTIVE
  To evaluate objectively and subjectively the long-term outcome of laser in situ keratomileusis (LASIK) in patients with high and very high myopia.
  
  
  METHODS
  Department of Ophthalmology, Philipps University, Marburg, Germany.
  
  
  METHODS
  Thirty-three eyes of 19 patients were followed for a mean of 76 months (range 50 to 84 months) after primary LASIK using the Keratom I excimer laser (Schwind) and the ALK microkeratome (Chiron). Refraction, glare, pachymetry, corneal topography, and tear-film secretion and stability were measured. At the last examination, patients also answered a 14-item questionnaire.
  
  
  RESULTS
  Preoperatively, the mean spherical equivalent was -13.65 diopters (D). At 1 year, it was -0.25 D and after 6 years, -0.88 D. Fifteen percent of eyes lost > or =2 lines of best spectacle-corrected visual acuity (BSCVA), and 9% gained > or =2 Snellen lines. At the end of the study, 46% of eyes were within +/-1.0 D of the attempted corrected and 88% were within +/-3.0 D. There were 5 microkeratome-associated complications; 3 resulted in loss of BSCVA. The latest pachymetry showed a mean corneal thickness of 498.5 microm (range 396 to 552 microm). There were no cases of keratectasia. Seventy-five percent of patients noted an increase in their quality of life. Seventy-one percent were satisfied with their postoperative visual acuity; however, 75% noticed glare and halos at night.
  
  
  CONCLUSIONS
  Laser in situ keratomileusis correction of very high myopia did not cause keratectasia in the long term provided the corneal thickness was respected. A flap thickness setting of 130 microm with a first-generation microkeratome resulted in a high number of cut failures. Most patients were happy with the results despite a modest level of accuracy and glare.
authors.affiliation: Department of Ophthalmology, Philipps-University Marburg, Germany. sekundo@med.uni-marburg.de
authors.forename: Walter
authors.initials: W
authors.lastname: Sekundo
authors.forename: Katrin
authors.initials: K
authors.lastname: Bönicke
authors.forename: Peter
authors.initials: P
authors.lastname: Mattausch
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wiegand
mesh_terms: D000328:Adult; D003315:Cornea / Q000502:physiology / Q000601:surgery*; D019781:Corneal Topography; D004108:Dilatation, Pathologic / Q000517:prevention & control; D005500:Follow-Up Studies; D019466:Glare; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000295:instrumentation / Q000379:methods; D008875:Middle Aged; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D017060:Patient Satisfaction; D012449:Safety; D012677:Sensation / Q000502:physiology; D013524:Surgical Flaps; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014792:Visual Acuity