Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae).
Extracts and isolated compounds from seedlings of Ailanthus altissima, were assessed for antiplasmodial activity in vitro. Two quassinoids, ailanthone and 6alpha-tigloyloxychaparrinone, isolated from the active extracts showed activity against both chloroquine-resistant and chloroquine-sensitive strains of Plasmodium falciparum in vitro. Only ailanthone demonstrated low toxicity against the Vero cell line (kidney cells from the African green monkey). This is the first report of the isolation and antiplasmodial activity of 6alpha-tigloyloxychaparrinone from this species.
Okunade
Adewole L
AL
Department of Biology, Washington University in St Louis, MO 63130, USA. Okunade@biology.wostl.edu
Bikoff
Rachel E
RE
Casper
Steven J
SJ
Oksman
Anna
A
Goldberg
Daniel E
DE
Lewis
Walter H
WH
D032268:Ailanthus; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002522:Chlorocebus aethiops; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects*; D036702:Quassins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D036226:Seedlings; D014709:Vero Cells
D000962:Antimalarials; D010936:Plant Extracts; D036702:Quassins