Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark.
The prenylisoflavone warangalone has been isolated from the bark of Erythrina addisoniae. This compound, previously recognized as a powerful inhibitor of protein kinase A, showed marked effectiveness as an anti-inflammatory on the phospholipase A(2)-induced paw edema and on the 12-O-tetradecanoylphorbol 13-acetate-induced ear edema in mice, after systemic and local administration, respectively.
Talla
Emmanuel
E
Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, P.O. Box 812, Yaounde, Cameroon.
Njamen
Dieudonné
D
Mbafor
Joseph Tanyi
JT
Fomum
Zacharias Tanee
ZT
Kamanyi
Albert
A
Mbanya
Jean-Claude
JC
Giner
Rosa M
RM
Recio
M Carmen
MC
Máñez
Salvador
S
Ríos
José Luis
JL
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001792:Blood Platelets; D017868:Cyclic AMP-Dependent Protein Kinases / Q000037:antagonists & inhibitors; D004423:Ear; D004487:Edema; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004895:Erythrina / Q000737:chemistry*; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors; D051379:Mice; D015394:Molecular Structure; D010741:Phospholipases A / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004791:Enzyme Inhibitors; D007529:Isoflavones; D007975:Leukotriene B4; C105205:warangalone; D011451:Prostaglandin-Endoperoxide Synthases; D017868:Cyclic AMP-Dependent Protein Kinases; D010741:Phospholipases A