Signalling from adenosine receptors to mitogen-activated protein kinases.
The purine nucleoside adenosine acts via four distinct adenosine receptor subtypes: the adenosine A(1), A(2A), A(2B), and A(3) receptor. They are all G protein-coupled receptors (GPCR) coupling to classical second messenger pathways such as modulation of cAMP production or the phospholipase C (PLC) pathway. In addition, they couple to mitogen-activated protein kinases (MAPK), which could give them a role in cell growth, survival, death and differentiation. Although each of the adenosine receptors can activate one or more of the MAPKs, the mechanisms appear to differ substantially, both between receptor subtypes in the same cell type and between the same receptor in different cell types.
Schulte
Gunnar
G
Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77, Stockholm, Sweden. gunnar.shulte@fyfa.kikse
Fredholm
Bertil B
BB
D000241:Adenosine / Q000819:agonists / Q000502:physiology; D000818:Animals; D000242:Cyclic AMP / Q000502:physiology; D004705:Endocytosis / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism* / Q000502:physiology; D008954:Models, Biological; D010766:Phosphorylation; D043682:Receptor, Adenosine A1 / Q000502:physiology; D043705:Receptor, Adenosine A2A / Q000502:physiology; D043704:Receptor, Adenosine A2B / Q000502:physiology; D043684:Receptor, Adenosine A3 / Q000502:physiology; D043683:Receptors, Adenosine A2 / Q000502:physiology; D018047:Receptors, Purinergic P1 / Q000502:physiology*; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D010738:Type C Phospholipases / Q000502:physiology; D048051:p38 Mitogen-Activated Protein Kinases
D043682:Receptor, Adenosine A1; D043705:Receptor, Adenosine A2A; D043704:Receptor, Adenosine A2B; D043684:Receptor, Adenosine A3; D043683:Receptors, Adenosine A2; D018047:Receptors, Purinergic P1; D000242:Cyclic AMP; D048031:JNK Mitogen-Activated Protein Kinases; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins; D000241:Adenosine