title: Clinicopathologic features in patients with long-term survival following resection for intrahepatic cholangiocarcinoma.
abstract: OBJECTIVE
  As the overall prognosis for patients with intrahepatic cholangiocarcinoma is extremely poor, it is important to identify specific clinicopathologic features associated with long-term survival after hepatic resection for this tumor.
  
  
  METHODS
  Of 54 patients who underwent hepatic resection for intrahepatic cholangiocarcinoma, 9 survived more than 5 years after surgery (survival group), while 28 patients died of recurrence within 3 years of surgery (early recurrence group). Clinicopathologic features were compared retrospectively between groups.
  
  
  RESULTS
  Although clinical features in patients with long-term survival were similar to those in patients with early recurrence, lymphatic invasion, lymph node metastasis, intrahepatic metastasis and tumor involving the resection margin were more frequent in patients with early recurrence.
  
  
  CONCLUSIONS
  Hepatic resection for intrahepatic cholangiocarcinoma without lymph node metastasis or intrahepatic metastasis offers hope for long-term survival.
authors.affiliation: Department of Gastroenterological and Hepato-biliary-pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan. m6877710@msic.med.osaka-cu.ac.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Uenishi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hirohashi
authors.forename: Shoji
authors.initials: S
authors.lastname: Kubo
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamazaki
authors.forename: Taichi
authors.initials: T
authors.lastname: Shuto
authors.forename: Hiromu
authors.initials: H
authors.lastname: Tanaka
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kinoshita
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000473:pathology* / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D011379:Prognosis