Poly(oligonucleotide) conjugates: applications in assembling nanoparticles and in detecting DNA sequences.
The chemistry of oligonucleotide-nanoparticle conjugates is described. Examples are provided to illustrate (i) the utility of oligonucleotide linkers in constructing ordered nanoparticle assemblies and (ii) applications of nanoparticles as reporters for nucleic acid hybridization.
Letsinger
R L
RL
Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Mirkin
C A
CA
Park
S J
SJ
Viswanadham
G
G
Zhang
L
L
D006046:Gold / Q000737:chemistry; D009693:Nucleic Acid Hybridization / Q000379:methods*; D015345:Oligonucleotide Probes / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D017422:Sequence Analysis, DNA
D015345:Oligonucleotide Probes; D009841:Oligonucleotides; D011108:Polymers; D006046:Gold