Applications of NMR to structure-based drug design in structural genomics.
Structural genomics is poised to have a tremendous impact on traditional structure-based drug design programs. As a result, there is a growing need to obtain rapid structural information in a reliable form that is amenable to rational drug design. In this manner, NMR has been expanding and evolving its role in aiding the design process. A variety of NMR methodologies that cover a range of inherent resolution are described in the context of structure-based drug design in the era of structural genomics.
Powers
Robert
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Department of Biological Chemistry, Wyeth Research, 87 Cambridge Park Dr., Cambridge, Massachusetts 02140, USA. powersr@war.wyeth.com
D002850:Chromatography, Gel; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D023281:Genomics; D008024:Ligands; D013058:Mass Spectrometry; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000378:metabolism; D011485:Protein Binding; D025941:Protein Interaction Mapping; D017433:Protein Structure, Secondary; D011506:Proteins / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship
D008024:Ligands; D004364:Pharmaceutical Preparations; D011506:Proteins