Study on curcumin-oligonucleotide conjugate as a probable anticancer agent: its hybridisation with telomere target sequence 5'-GGGATTGGGATT-3'.
Curcumin-oligonucleotide conjugate was synthesised by attaching diglycyl conjugate of curcumin to 12-mer complementary telomere sequence 5'-AATCCCAATCCC-3'. An enhanced Tm of 6 degrees C was found, showing high affinity for the target strand. This may be exploited for the suppression of cancer i.e. by blocking the expression of telomere sequence [GGGATT]n repeats.
Kumar
S
S
Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211 002, India.
Misra
A
A
Tripathi
S
S
Misra
K
K
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry*; D001483:Base Sequence; D003474:Curcumin / Q000737:chemistry*; D016503:Drug Delivery Systems; D009691:Nucleic Acid Denaturation; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D012091:Repetitive Sequences, Nucleic Acid; D016615:Telomere / Q000737:chemistry*; D013696:Temperature
D000970:Antineoplastic Agents; D009841:Oligonucleotides; D003474:Curcumin