title: Sea urchin deciliation induces thermoresistance and activates the p38 mitogen-activated protein kinase pathway.
abstract: In this study, we demonstrate by a variety of approaches (ie, morphological analysis, Western blots, immunolocalization, and the use of specific antibodies) that hyperosmotic deciliation stress of sea urchin embryos induces a thermotolerant response. Deciliation is also able to activate a phosphorylation signaling cascade the effector of which might be the p38 stress-activated protein kinase because we found that the administration of the p38 inhibitor SB203580 to sea urchin deciliated gastrula embryos makes the hyperosmotic deciliation stress lethal.
authors.affiliation: Dipartimento di Biologia Cellulare e dello Sviluppo "A. Monroy," Università di Palermo, Viale delle Scienze, Parco D'Orleans, 90128 Palermo, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Casano
authors.forename: Maria Carmela
authors.initials: MC
authors.lastname: Roccheri
authors.forename: Luisa
authors.initials: L
authors.lastname: Maenza
authors.forename: Silvia
authors.initials: S
authors.lastname: Migliore
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Gianguzza
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D002923:Cilia / Q000502:physiology*; D004591:Electrophoresis, Polyacrylamide Gel; D004789:Enzyme Activation; D005775:Gastrula / Q000201:enzymology / Q000502:physiology*; D006358:Hot Temperature; D007093:Imidazoles / Q000494:pharmacology; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010766:Phosphorylation; D011725:Pyridines / Q000494:pharmacology; D012617:Sea Urchins / Q000196:embryology*; D015398:Signal Transduction / Q000502:physiology; D013312:Stress, Physiological; D048051:p38 Mitogen-Activated Protein Kinases
chemical_list: D000911:Antibodies, Monoclonal; D007093:Imidazoles; D011725:Pyridines; D020928:Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases; C093642:SB 203580