Magnetic resonance-defined periportal steatosis following intraportal islet transplantation: a functional footprint of islet graft survival?
There is growing interest in more widespread application of isolated islet transplantation for the treatment of type 1 diabetes; however, the sequelae of long-term islet residence within the liver are unknown. We report herein a consequence of intraportal islet transplantation, specifically the development of periportal hepatic steatosis apparently induced by the local secretion of insulin within the liver.
Markmann
James F
JF
Department of Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA. james.markmann@uphs.upenn.edu
Rosen
Mark
M
Siegelman
Evan S
ES
Soulen
Michael C
MC
Deng
Shaoping
S
Barker
Clyde F
CF
Naji
Ali
A
D005500:Follow-Up Studies; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016381:Islets of Langerhans Transplantation / Q000379:methods* / Q000502:physiology; D008099:Liver / Q000033:anatomy & histology* / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology*
D007166:Immunosuppressive Agents