Organic synthesis using polymer-supported reagents, catalysts and scavengers in simple laboratory flow systems.
The use of appropriate combinations of polymer-supported reagents, catalysts and/or scavengers is a powerful approach, both for the synthesis of single organic compounds and for parallel syntheses. A further stage of development is the use of such reactants in flow systems. So far, it has been shown that a variety of flow formats afford excellent chemical yields and, where relevant, excellent enantiomeric excesses. The supports have a longer lifetime than in batch systems. 'Flow cascades' promise to be important in future.
Hodge
Philip
P
Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK. philip.hodge@man.ac.uk
D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods*; D007202:Indicators and Reagents; D010455:Peptides / Q000138:chemical synthesis; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
D007202:Indicators and Reagents; D010455:Peptides; D011108:Polymers