Very low-frequency heart rate variability wave amplitude and sympathetic stimulation--characterization and modeling.
The purpose of this study was to assess the relationship between very low-frequency heart rate variability (LFHR) wave amplitude and the degree of sympathetic stimulation. We developed a computerized system for the controlled increase of heart rate (HR) by isoproterenol (ISP), with which we obtained a series of stabilized HR levels in conscious freely moving rats. We found that LFHR amplitude rises gradually as a function of the average HR for each level until it reaches a point where additional increases in average HR are associated with gradual decrease in LFHR amplitude. We successfully built and fitted a model of LFHR amplitude to the experimental results. The fact that our model fits the experimental data well may suggest a possible relationship between our LFHR amplitude findings and the basic physiologic properties of the HR-ISP system inherent in our model.
Leor-Librach
Ron Joseph
RJ
Heart Institute, Laniado Hospital, Sanz Medical Center, Netanya, P.O. Box 744, Netanya 42107, Israel. rellb@post.tau.ac.il
Eliash
Sarah
S
Kaplinsky
Elieser
E
Bobrovsky
Ben-Zion
BZ
D000818:Animals; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D005583:Fourier Analysis; D006321:Heart / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology*; D006487:Hemostasis / Q000502:physiology; D007262:Infusions, Intravenous; D007545:Isoproterenol / Q000008:administration & dosage*; D008955:Models, Cardiovascular; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D013223:Statistics as Topic; D013566:Sympathomimetics / Q000008:administration & dosage
D013566:Sympathomimetics; D007545:Isoproterenol