title: Postpartum hemorrhagic shock resulting in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome.
abstract: Thrombotic microangiopathies may be initiated by a number of antecedent events. When presented with postpartum hemorrhage and unexplained thrombocytopenia, it is prudent to consider microangiopathic hemolytic anemia in the differential diagnosis. A 25-year-old woman, gravida 2, para 1, had an uncomplicated repeat Cesarean delivery at 38 weeks' gestation. She subsequently had an exploratory laparotomy for hemoperitoneum resulting from a left uterine artery laceration. On postoperative day 3, she developed thrombotic chrombocytopenic purpura-hemolytic uremic syndrome and was treated with plasma exchange therapy and dialysis. It is critical that clinicians consider this potentially fatal disease in the differential diagnosis when hemorrhagic shock is associated with unexplained thrombocytopenia, so that appropriate and early treatment may lead to a favorable outcome.
authors.affiliation: Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas 77555-0587, USA.
authors.forename: M
authors.initials: M
authors.lastname: Rosen
authors.forename: K I
authors.initials: KI
authors.lastname: Brauer
authors.forename: J B
authors.initials: JB
authors.lastname: Alperin
authors.forename: G D V
authors.initials: GD
authors.lastname: Hankins
authors.forename: G
authors.initials: G
authors.lastname: Saade
mesh_terms: D000328:Adult; D001158:Arteries / Q000293:injuries; D002585:Cesarean Section / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006465:Hemoperitoneum / Q000209:etiology*; D006801:Humans; D010951:Plasma Exchange; D006473:Postpartum Hemorrhage / Q000209:etiology*; D011247:Pregnancy; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006435:Renal Dialysis; D012771:Shock, Hemorrhagic / Q000209:etiology*