title: Laser and proton radiation to reduce uveal melanoma-associated exudative retinal detachments.
abstract: OBJECTIVE
  To assess whether laser-induced hyperthermia with proton irradiation of choroidal melanoma may decrease exudative retinal detachments more rapidly.
  
  
  METHODS
  Case control study.
  
  
  METHODS
  Patients treated with laser-induced hyperthermia and proton radiation; results were compared with similar patients treated with only protons.
  
  
  RESULTS
  All 11 patients treated with combined laser and proton therapy had resorption of subretinal fluid with a mean duration of retinal detachment of 193 days compared with 263 days in the group treated with only proton therapy (P <.04). At 1 year, visual acuity was similar.
  
  
  CONCLUSIONS
  Combined laser radiation more rapidly dissipates exudative detachments than radiation alone.
authors.affiliation: Tumori Foundation CPMC , San Francisco, California, USA. devron@tumori.org
authors.forename: Devron H
authors.initials: DH
authors.lastname: Char
authors.forename: Riley
authors.initials: R
authors.lastname: Bove
authors.forename: Theodore L
authors.initials: TL
authors.lastname: Phillips
mesh_terms: D016022:Case-Control Studies; D002830:Choroid Neoplasms / Q000150:complications / Q000628:therapy*; D003131:Combined Modality Therapy; D005122:Exudates and Transudates; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007834:Lasers; D008297:Male; D008545:Melanoma / Q000150:complications / Q000628:therapy*; D008875:Middle Aged; D011522:Protons; D011882:Radiotherapy, High-Energy / Q000379:methods*; D012163:Retinal Detachment / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D011522:Protons