Pneumonia in term neonates: laboratory studies and duration of antibiotic therapy.
OBJECTIVE
To compare 2 days of antibiotic therapy (AT) to 4 days of AT in neonates with pneumonia and to assess the usefulness of neutrophil values (NV), C-reactive protein (CRP), and procalcitonin (PCT) in this population.


METHODS
The study population consisted of consecutive, eligible term neonates begun on AT for suspected pneumonia. Of 51 neonates, 26 qualified for randomization (14, 2-day group; 12, 4-day group). NV were obtained with the initial evaluation and 12 and 24 hours later. CRP and PCT were obtained 12 and 48 hours after the initial evaluation.


RESULTS
None of the 12 neonates in the 4-day group developed recurrent respiratory symptoms. Three of the 14 neonates randomized to the 2-day group had recurrence of symptoms, resulting in study termination. NV, CRP, and PCT were similar in the 2- and 4-day groups. In the three neonates who developed respiratory symptoms, all absolute total neutrophil values and five out of nine absolute total immature neutrophil values were abnormal. However, all immature:total neutrophil values were normal, and CRP was strikingly elevated in only one neonate; only one of six PCT values was abnormal. In a secondary analysis of all 51 study neonates, CRP and PCT did not provide additional benefit over NV in differentiating neonates with pneumonia.


CONCLUSIONS
Four days of AT appears to be adequate for selected term neonates with pneumonia; however, 2 days of AT appears to be inadequate for this population. Relative to NV, CRP and PCT appear to have a limited role.
Engle
William D
WD
Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9063, USA.
Jackson
Gregory L
GL
Sendelbach
Dorothy M
DM
Stehel
Elizabeth K
EK
Ford
Diane M
DM
McHugh
Kathleen M
KM
Norris
Margienetta R
MR
Vedro
Debra A
DA
Velaphi
Sithembiso
S
Michelow
Ian C
IC
Olsen
Kurt D
KD
D000667:Ampicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001724:Birth Weight; D019411:Clinical Laboratory Techniques; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D005839:Gentamicins / Q000008:administration & dosage; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D007363:Intensive Care Units, Neonatal; D008297:Male; D010406:Penicillins / Q000008:administration & dosage; D018410:Pneumonia, Bacterial / Q000175:diagnosis* / Q000188:drug therapy*; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D000667:Ampicillin