title: Novel inhibitors of procollagen C-proteinase. Part 2: glutamic acid hydroxamates.
abstract: Glutamic acid derived hydroxamates were identified as potent and selective inhibitors of procollagen C-proteinase, an essential enzyme for the processing of procollagens to fibrillar collagens. Such compounds have potential therapeutic application in the treatment of fibrosis.
authors.affiliation: CombiChem Inc., 4570 Executive Drive, 92121, San Diego, CA, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Robinson
authors.forename: D M
authors.initials: DM
authors.lastname: Wilson
authors.forename: N G J
authors.initials: NG
authors.lastname: Delaet
authors.forename: E K
authors.initials: EK
authors.lastname: Bradley
authors.forename: S M
authors.initials: SM
authors.lastname: Dankwardt
authors.forename: J A
authors.initials: JA
authors.lastname: Campbell
authors.forename: R L
authors.initials: RL
authors.lastname: Martin
authors.forename: H E
authors.initials: HE
authors.lastname: Van Wart
authors.forename: K A M
authors.initials: KA
authors.lastname: Walker
authors.forename: R W
authors.initials: RW
authors.lastname: Sullivan
mesh_terms: D055395:Bone Morphogenetic Protein 1; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005971:Glutamates / Q000138:chemical synthesis* / Q000494:pharmacology*; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007700:Kinetics; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000378:metabolism*; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D019485:Bone Morphogenetic Proteins; D005971:Glutamates; D006877:Hydroxamic Acids; D007202:Indicators and Reagents; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D008666:Metalloendopeptidases; D055395:Bone Morphogenetic Protein 1