title: Modulation of DNA-mediated hole transport efficiency by DNA-protein complex formation.
abstract: To investigate how protein interactions to DNA affects DNA-mediated hole transport, hole transport through the DNA bound to restriction endonuclease BamHI was examined. The DNA bound to BamHI retains a regular B-DNA type of conformation, but have a number of hydrogen bonding interaction. These hydrogen bondings in BamHI-DNA complex suppressed the guanine oxidation and the hole transport in sequence selective manner.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606-8501, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Dohno
authors.forename: K
authors.initials: K
authors.lastname: Nakatani
authors.forename: I
authors.initials: I
authors.lastname: Saito
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D015245:Deoxyribonuclease BamHI / Q000737:chemistry* / Q000378:metabolism; D006860:Hydrogen Bonding; D017136:Ion Transport; D046911:Macromolecular Substances
chemical_list: D004268:DNA-Binding Proteins; D046911:Macromolecular Substances; D004247:DNA; D015245:Deoxyribonuclease BamHI