Postmortem toxicology of carbamazepine.
The study focuses on a series of 16 fatal cases in which carbamazepine and its two major metabolites (10,11-epoxide and 10,11-dihydroxycarbamazepine) were detected in body fluids and tissues collected at autopsy. The drug may be implicated in a number of deaths; however, most of these are multiple-drug intoxications with a particular contribution of ethanol. The investigations concerning toxicological findings are a source of toxicological postmortem data and show the differences in metabolism rate as depending on the concentration level of carbamazepine and xenobiotics found in the autopsy specimen during the postmortem investigation of a body.
Klys
Malgorzata
M
Collegium Medicum Jagiellonian University, Institute of Forensic Medicine, Department of Toxicology, 16 Grzegórzecka Street, 31-531 Kraków, Poland.
Bystrowska
Beata
B
Bujak-Gizycka
Beata
B
D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000097:blood* / Q000506:poisoning*; D001344:Autopsy; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000097:blood* / Q000506:poisoning*; D002853:Chromatography, Liquid; D062787:Drug Overdose; D000431:Ethanol; D017809:Fatal Outcome; D006708:Homicide; D006801:Humans; D013058:Mass Spectrometry; D008875:Middle Aged; D013405:Suicide
D000927:Anticonvulsants; D002220:Carbamazepine; C004822:10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide; D000431:Ethanol; C012227:carbamazepine epoxide