title: Adduct formation between oxanine and amine derivatives.
abstract: Oxanine (Oxa) is a major guanine lesion produced by nitric oxide (NO) under aerobic conditions. To elucidate the genotoxic mechanism of Oxa, this lesion was site-specifically incorporated into an oligonucleotide and allowed to react with cellular amines. Analysis of the reaction product revealed that Oxa formed adducts with spermidine and lysine, suggesting a novel genotoxic mechanism associated with NO-induced DNA damage.
authors.affiliation: Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima 739-8526, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: H
authors.initials: H
authors.lastname: Terato
authors.forename: K
authors.initials: K
authors.lastname: Asagoshi
authors.forename: Y
authors.initials: Y
authors.lastname: Ohyama
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Makino
authors.forename: H
authors.initials: H
authors.lastname: Ide
mesh_terms: D000588:Amines / Q000737:chemistry*; D018736:DNA Adducts / Q000138:chemical synthesis* / Q000737:chemistry; D008239:Lysine / Q000737:chemistry; D011684:Purine Nucleosides / Q000737:chemistry*; D013095:Spermidine / Q000737:chemistry
chemical_list: D000588:Amines; D018736:DNA Adducts; D011684:Purine Nucleosides; C468766:oxanine; D008239:Lysine; D013095:Spermidine