Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria.
Gender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.
Jensen
Anja T R
AT
Centre for Medical Parasitology, Copenhagen University Hospital (Rigshospitalet) and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark.
Zornig
Hanne D
HD
Buhmann
Caecilie
C
Salanti
Ali
A
Koram
Kwadwo A
KA
Riley
Eleanor M
EM
Theander
Thor G
TG
Hviid
Lars
L
Staalsoe
Trine
T
D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D002809:Chondroitin Sulfates / Q000502:physiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016778:Malaria, Falciparum / Q000276:immunology*; D008297:Male; D010298:Parity; D010963:Plasmodium falciparum / Q000235:genetics / Q000276:immunology*; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000276:immunology*; D015800:Protozoan Proteins / Q000235:genetics*; D012737:Sex Factors
D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D015800:Protozoan Proteins; C085731:erythrocyte membrane protein 1, Plasmodium falciparum; D002809:Chondroitin Sulfates