title: Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae).
abstract: Extracts and isolated compounds from seedlings of Ailanthus altissima, were assessed for antiplasmodial activity in vitro. Two quassinoids, ailanthone and 6alpha-tigloyloxychaparrinone, isolated from the active extracts showed activity against both chloroquine-resistant and chloroquine-sensitive strains of Plasmodium falciparum in vitro. Only ailanthone demonstrated low toxicity against the Vero cell line (kidney cells from the African green monkey). This is the first report of the isolation and antiplasmodial activity of 6alpha-tigloyloxychaparrinone from this species.
authors.affiliation: Department of Biology, Washington University in St Louis, MO 63130, USA. Okunade@biology.wostl.edu
authors.forename: Adewole L
authors.initials: AL
authors.lastname: Okunade
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Bikoff
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Casper
authors.forename: Anna
authors.initials: A
authors.lastname: Oksman
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Goldberg
authors.forename: Walter H
authors.initials: WH
authors.lastname: Lewis
mesh_terms: D032268:Ailanthus; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002522:Chlorocebus aethiops; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects*; D036702:Quassins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D036226:Seedlings; D014709:Vero Cells
chemical_list: D000962:Antimalarials; D010936:Plant Extracts; D036702:Quassins