A role for neuropeptide Y in alcohol intake control: evidence from human and animal research.
This article is based on proceedings of a symposium presented at the 2002 meeting of the Society for the Study of Ingestive Behavior and provides a brief overview of recent research suggesting a role for neuropeptide Y (NPY) in the modulation of ethanol drinking. The discussion focuses mainly on recent studies with genetic animal models including mutant mice lacking specific NPY receptor and selectively bred rodents, namely the Indiana alcohol-preferring (P) and alcohol-nonpreferring (NP) rats and the Indiana high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. It is concluded that abnormal or low central NPY activity can promote high alcohol drinking and that NPY modulates alcohol consumption via the NPY Y1 and Y2 receptors.
Thiele
Todd E
TE
Department of Psychology and the Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Davie Hall, CB#3270, Chapel Hill, NC 27599-3270, USA. thiele@unc.edu
Badia-Elder
Nancy E
NE
D000428:Alcohol Drinking / Q000235:genetics / Q000503:physiopathology*; D000437:Alcoholism / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains; D008957:Models, Genetic; D009478:Neuropeptide Y / Q000235:genetics / Q000502:physiology*; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000235:genetics; D018013:Receptors, Neuropeptide / Q000235:genetics; D017476:Receptors, Neuropeptide Y / Q000235:genetics; D012106:Research
D009478:Neuropeptide Y; C066211:Npy1r protein, rat; D043562:Receptors, G-Protein-Coupled; D018013:Receptors, Neuropeptide; D017476:Receptors, Neuropeptide Y; C095889:neuropeptide Y2 receptor