title: Functional genomics and proteomics: charting a multidimensional map of the yeast cell.
abstract: The challenge of large-scale functional genomics projects is to build a comprehensive map of the cell including genome sequence and gene expression data, information on protein localization, structure, function and expression, post-translational modifications, molecular and genetic interactions and phenotypic descriptions. Some of this broad set of functional genomics data has been already assembled for the budding yeast. Even though molecular cartography of the yeast cell is still far from comprehensive, functional genomics has begun to forge connections between disparate cellular events and to foster numerous hypotheses. Here we review several different genomics and proteomics technologies and describe bioinformatics methods for exploring these data to make new discoveries.
authors.affiliation: Computational Biology Center, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 460, 10021, New York, NY, USA.
authors.forename: Gary D
authors.initials: GD
authors.lastname: Bader
authors.forename: Adrian
authors.initials: A
authors.lastname: Heilbut
authors.forename: Brenda
authors.initials: B
authors.lastname: Andrews
authors.forename: Mike
authors.initials: M
authors.lastname: Tyers
authors.forename: Timothy
authors.initials: T
authors.lastname: Hughes
authors.forename: Charles
authors.initials: C
authors.lastname: Boone
mesh_terms: D002874:Chromosome Mapping; D019295:Computational Biology; D015966:Gene Expression Regulation, Fungal / Q000235:genetics*; D023281:Genomics; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D040901:Proteomics; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism* / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins