A new cyclic peptide from a marine-derived bacterium of the genus Nocardiopsis.
A new cyclic tetrapeptide (1) was isolated from the culture broth of an actinomycete of the genus Nocardiopsis collected from the Pacific deep-sea sediment. The structure of this compound was determined to be cyclo-(L-isoleucyl-L-prolyl-L-leucyl-L-prolyl) on the basis of combined chemical and spectral methods.
Shin
Jongheon
J
Natural Products Research Institute, College of Pharmacy, Seoul National University, #28 Yungun, Jongro, Seoul 110-460, Korea. shinj@snu.ac.kr
Seo
Youngwan
Y
Lee
Hyi-Seung
HS
Rho
Jung-Rae
JR
Mo
Sang Jun
SJ
D000192:Actinomycetales / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010140:Pacific Ocean; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C478842:cyclo-(L-isoleucyl-L-prolyl-L-leucyl-L-prolyl)