Three new cytotoxic acylspermidines from the soft coral, Sinularia sp.
Three new acylated spermidines and two known related compounds were isolated from the Okinawan soft coral, Sinularia sp. These compounds were N',N",N"-trimethylspermidines that are acylated by a methyl-branched unsaturated fatty acid. These acylspermidines showed potent cytotoxicity against human tumor cell lines at an IC(50) value of 17 ng/ml and the induction of apoptotic phenomena.
Ojika
Makoto
M
Graduate School of Bioagricultural Sciences, Nagoya University, Chijusa-ku, Nagoya 464-8601, Japan. ojika@agr.nagoya-u.ac.jp
Islam
Mohammad Kamrul
MK
Shintani
Tomoaki
T
Zhang
Yang
Y
Okamoto
Tetsuji
T
Sakagami
Youji
Y
D000215:Acylation; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005231:Fatty Acids, Unsaturated; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013095:Spermidine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology*; D014118:Toxins, Biological / Q000302:isolation & purification*
D000970:Antineoplastic Agents; D005231:Fatty Acids, Unsaturated; D014118:Toxins, Biological; D013095:Spermidine