Desperately seeking genotype-selective anticancer agents.
An approach has been described to identify new agents that selectively kill mammalian cells with multiple genetic abnormalities. Compounds of this type could lead to innovative cancer treatments based on tumor genotype rather than by histology or anatomical location.
Lazo
John S
JS
Department of Pharmacology, University of Pittsburgh, Pittsburgh, PA 15232, USA.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics; D009857:Oncogenes / Q000187:drug effects*; D010641:Phenotype; D014407:Tumor Cells, Cultured / Q000187:drug effects; D015003:Yeasts / Q000235:genetics
D000970:Antineoplastic Agents