The use of Raman spectroscopy to identify and grade prostatic adenocarcinoma in vitro.
Raman spectroscopy is an optical technique, which provides a measure of the molecular composition of tissue. Raman spectra were recorded in vitro from both benign and malignant prostate biopsies, and used to construct a diagnostic algorithm. The algorithm was able to correctly identify each pathological group studied with an overall accuracy of 89%. The technique shows promise as a method for objectively grading prostate cancer.
Crow
P
P
Cranfield Post-Graduate Medical School, Pullman Court, Gloucestershire Royal Hospital, Great Western Road, Gloucester, GL1 3NN, UK. paul_crow@hotmail.com
Stone
N
N
Kendall
C A
CA
Uff
J S
JS
Farmer
J A M
JA
Barr
H
H
Wright
M P J
MP
D000230:Adenocarcinoma / Q000145:classification / Q000473:pathology*; D000465:Algorithms; D001706:Biopsy; D006801:Humans; D008297:Male; D009367:Neoplasm Staging / Q000379:methods*; D011471:Prostatic Neoplasms / Q000145:classification / Q000473:pathology*; D012680:Sensitivity and Specificity; D013059:Spectrum Analysis, Raman