title: Surgical management of proximal bile duct cancer: extended right lobe resection increases resectability and radicality.
abstract: BACKGROUND
  Surgical resection provides the only chance of cure for patients suffering from hilar cholangiocarcinoma. Although appropriate procedures are not agreed upon, an increase in radicality has been observed during the past 20 years.
  
  
  METHODS
  The literature as well as our own experience after 133 resections of hilar cholangiocarcinomas were reviewed.
  
  
  RESULTS
  Tumor-free margins represent the most important prognostic parameter. Hilar resections as least radical resective procedure will generate rates of formally curative resections of less than 50%. Even after these formally curative resections, long-term survival cannot be achieved. Only additional liver resections will increase the number of long-term survivors to significant figures. In our series, the best 5-year survival rate of 72% was achieved after right trisegmentectomy with concomitant resection of the portal vein bifurcation.
  
  
  CONCLUSIONS
  Right trisegmentectomy and combined portal vein resection represent the best way to comply with basic rules of surgical oncology for hilar cholangiocarcinoma. This procedure will provide the most pronounced benefit among various types of liver resection, whereas local resections of the extrahepatic bile duct must be considered as an oncologically inefficient procedure.
authors.affiliation: Klinik für Allgemein-, Viszeral und Transplantationschirurgie, Charité, Campus Virchow Klinikum, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. peter.neuhaus@charite.de
authors.forename: Peter
authors.initials: P
authors.lastname: Neuhaus
authors.forename: Sven
authors.initials: S
authors.lastname: Jonas
authors.forename: Utz
authors.initials: U
authors.lastname: Settmacher
authors.forename: Armin
authors.initials: A
authors.lastname: Thelen
authors.forename: Christoph
authors.initials: C
authors.lastname: Benckert
authors.forename: Enrique
authors.initials: E
authors.lastname: Lopez-Hänninen
authors.forename: Rainer E
authors.initials: RE
authors.lastname: Hintze
mesh_terms: D001650:Bile Duct Neoplasms / Q000401:mortality / Q000601:surgery*; D017734:Bile Ducts, Extrahepatic / Q000601:surgery; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000401:mortality / Q000601:surgery*; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D008197:Lymph Node Excision; D015996:Survival Rate