Neurologic deterioration in a child with Wilson's disease on penicillamine therapy.
Penicillamine is the standard therapy for Wilson's disease in children. We report an 8-year-old-girl with liver disease due to Wilson's disease who developed extrapyramidal symptoms following administration of penicillamine. Symptoms resolved within 20 hours of stopping the drug but recurred within 24 hours when gradually increasing small doses were recommenced.
Paul
Alexander Chandran
AC
Departments of Child Health, Christian Medical College and Hospital, Vellore 632 004, Tamil Nadu.
Varkki
Sneha
S
Yohannan
Nisha B
NB
Eapen
C E
CE
Chandy
George
G
Raghupathy
P
P
D002614:Chelating Agents / Q000009:adverse effects*; D002648:Child; D004305:Dose-Response Relationship, Drug; D005260:Female; D006527:Hepatolenticular Degeneration / Q000188:drug therapy*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000139:chemically induced*; D010396:Penicillamine / Q000009:adverse effects*; D013577:Syndrome
D002614:Chelating Agents; D010396:Penicillamine