title: Low-gradient aortic stenosis: operative risk stratification and predictors for long-term outcome: a multicenter study using dobutamine stress hemodynamics.
abstract: BACKGROUND
  The prognostic value of dobutamine stress hemodynamic data in the setting of low-gradient aortic stenosis has been addressed in small, single-center studies. Larger studies are needed to define the criteria for selecting the patients who will benefit from valve replacement.
  
  
  RESULTS
  Six centers prospectively enrolled 136 patients with aortic stenosis (96 men; median age, 72 years [range, 65 to 77 years]; median aortic valve area, 0.7 cm2 [range, 0.6 to 0.8]; mean transaortic gradient, 29 mm Hg [range, 23 to 34 mm Hg]; cardiac index, 2.11 L x min(-1) x m(-2) [range, 1.75 to 2.55 L x min(-1) x m(-2)]). Left ventricular contractile reserve on the dobutamine stress Doppler study was present in 92 patients (group I) and absent in 44 patients (group II). Operative mortality was 5% (3 of 64 patients) in group I compared with 32% (10 of 31 patients) in group II (P=0.0002). Predictors for operative mortality were the lack of contractile reserve (odds ratio, 10.9; 95% confidence interval [CI], 2.6 to 43.4; P=0.001) and a mean transaortic gradient < or =20 mm Hg (odds ratio, 4.7; 95% CI, 1.1 to 21.0; P=0.04). Predictors for long-term survival were valve replacement (hazard ratio, 0.30; 95% CI, 0.17 to 0.53; P=0.001) and left ventricular contractile reserve (hazard ratio, 0.40; 95% CI, 0.23 to 0.69; P=0.001).
  
  
  CONCLUSIONS
  In the setting of low-gradient aortic stenosis, surgery seems beneficial for most of the patients with left ventricular contractile reserve. In contrast, the postoperative outcome of patients without reserve is compromised by a high operative mortality. Thus, dobutamine stress Doppler hemodynamics may be factored into the risk-benefit analysis for each patient.
authors.affiliation: Department of Cardiology, Henri Mondor Hospital, 51 Avenue De Lattre de Tassigny, 94010 Créteil, France. jeanluc.monin@free.fr
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Monin
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Quéré
authors.forename: Mehran
authors.initials: M
authors.lastname: Monchi
authors.forename: Hélène
authors.initials: H
authors.lastname: Petit
authors.forename: Serge
authors.initials: S
authors.lastname: Baleynaud
authors.forename: Christophe
authors.initials: C
authors.lastname: Chauvel
authors.forename: Camélia
authors.initials: C
authors.lastname: Pop
authors.forename: Patrick
authors.initials: P
authors.lastname: Ohlmann
authors.forename: Claude
authors.initials: C
authors.lastname: Lelguen
authors.forename: Patrick
authors.initials: P
authors.lastname: Dehant
authors.forename: Christophe
authors.initials: C
authors.lastname: Tribouilloy
authors.forename: Pascal
authors.initials: P
authors.lastname: Guéret
mesh_terms: D000318:Adrenergic beta-Agonists; D000368:Aged; D001024:Aortic Valve Stenosis / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology* / Q000601:surgery; D001794:Blood Pressure; D003935:Diagnostic Techniques, Cardiovascular; D004280:Dobutamine; D015150:Echocardiography, Doppler; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D018570:Risk Assessment; D018401:Sample Size; D016019:Survival Analysis; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects / Q000401:mortality
chemical_list: D000318:Adrenergic beta-Agonists; D004280:Dobutamine