Minocycline-induced immune thrombocytopenia presenting as Schamberg's disease.
Minocycline hydrochloride, a synthetic tetracycline, is a systemic antibiotic that has received much attention over the past several years. Currently, minocycline is considered the most widely prescribed oral antibiotic in the management of acne. Minocycline has been associated with autoimmune events, hepatitis, lupus-like syndromes, serum sickness, vasculitis, Sweet's syndrome, and hyperpigmentation. We report a case of a patient who developed drug-induced immune thrombocytopenic purpura (DITP) after taking minocycline. The initial clinical presentation of nonpalpable, discrete nonblanching petechiae and cayenne pepper-like macules on his lower legs was diagnosed as pigmented purpuric dermatosis (Schamberg's disease). We report the first case of DITP with the clinical picture of Schamberg's disease associated with minocycline therapy.
D'Addario
Stephen F
SF
Department of Dermatology, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR 72205, USA.
Bryan
Matthew E
ME
Stringer
Warren A
WA
Johnson
Sandra Marchese
SM
D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects*; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000175:diagnosis; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000139:chemically induced* / Q000175:diagnosis
D008911:Minocycline