Prevalence and predictors of renal artery stenosis in Chinese patients with coronary artery disease.
BACKGROUND
Ischaemic nephropathy is currently a major public health issue in atherosclerotic populations. Although atherosclerotic cardiovascular disease in Asia has reached epidemic proportions over the last two decades, there is little published data on the prevalence of atherosclerotic renal artery stenosis (ARAS) in Oriental subjects. Because ARAS may be clinically silent until end-stage renal failure sets in, it is important to identify patients with significant but clinically unsuspected ARAS. ARAS and coronary artery disease (CAD) often coexist.


OBJECTIVE
The purpose of the present study was to evaluate the prevalence and predictors of ARAS among Chinese patients with CAD.


METHODS
A total of 230 consecutive Chinese patients with CAD confirmed by coronary angiography underwent an abdominal aortogram in the same sitting to screen for ARAS. Patient demographics and comorbidities were analysed for any association with ARAS.


RESULTS
A total of 34 (14.8%) patients was found to have significant ARAS. Age and multivessel CAD were independent predictors of ARAS. Hypertension, renal insufficiency, extracranial cerebrovascular disease and female gender were also associated with a higher risk of ARAS but did not independently predict ARAS.


CONCLUSIONS
Clinically silent yet angiographically significant ARAS is common among CAD patients. The prevalence and predictors of ARAS among Chinese patients with CAD are similar to those reported for Caucasian subjects. Underlying ARAS should be suspected in CAD patients with such comorbidities as hypertension, renal insufficiency, extracranial cerebrovascular disease, and more so in the elderly and those with multivessel disease.
Wang
Y
Y
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong.
Ho
D S W
DS
Chen
W H
WH
Wang
Y Q
YQ
Lam
W F
WF
Shen
Z J
ZJ
Lu
C Z
CZ
Chui
M
M
D017677:Age Distribution; D000368:Aged; D000704:Analysis of Variance; D000792:Angiography / Q000379:methods; D044466:Asian People; D015331:Cohort Studies; D015897:Comorbidity; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000453:epidemiology*; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015995:Prevalence; D011336:Probability; D011379:Prognosis; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging / Q000453:epidemiology*; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D015996:Survival Rate