Effect of anthocyanins on selected biochemical parameters in rats exposed to cadmium.
Cadmium is a dangerous occupational and environmental toxin. It accumulates in the human organism mainly in liver and kidneys. Cadmium half-life is about 10 years, so the symptoms of cadmium intoxication may occur several years after the exposure. Until now in treating intoxication with this metal chelating compounds have been used, burdened with numerous undesirable symptoms. In our investigations anthocyanins from Aronia melanocarpa were used to reduce the harmful results caused by cadmium. Administering anthocyanins with cadmium chloride resulted in a statistically significant decrease of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity, concentration of bilirubin and urea in blood serum and decreased cadmium cumulation in liver and kidneys in relation to animals receiving cadmium chloride only.
Kowalczyk
Edward
E
Department of Human Physiology and Biophysics, Medical University, Plac J. Hallera 1, 90-647 Łódź, Poland. farmak@achilles.wam.lodz.pl
Kopff
Anna
A
Fijałkowski
Paweł
P
Kopff
Maria
M
Niedworok
Jan
J
Błaszczyk
Jan
J
Kedziora
Józef
J
Tyślerowicz
Piotr
P
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002104:Cadmium / Q000378:metabolism / Q000633:toxicity*; D003404:Creatinine / Q000097:blood; D004906:Erythrocyte Count; D006400:Hematocrit; D006454:Hemoglobins; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D027824:Rosaceae / Q000737:chemistry; D014508:Urea / Q000097:blood
D000872:Anthocyanins; D006454:Hemoglobins; D002104:Cadmium; D014508:Urea; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin