title: [Nasal NK/T lymphoma. A case report].
abstract: We report a case of nasal NK/T lymphoma occurring in a 42 year old man, after a 2 year history of nasal obstruction initially related to chronic sinusitis. A first superficial biopsy was not contributive. Twenty months later, a second nasal biopsy led to the diagnosis of nasal NK/T cell lymphoma in view of the presence of a pleomorphic lymphoid infiltrate associated with necrosis and angiocentric features. Extensive immunohistochemical studies performed on paraffin and frozen sections together with genotypic analysis supported the NK cell origin of the neoplastic cells. In addition, EBV infection was established by in situ hybridization which showed EBERs transcripts in the nuclei of virtually all neoplastic cells. The tumour rapidly progressed and the patient died six months after diagnosis.
authors.affiliation: Centre National de Greffe de Moelle Osseuse, rue Jebel Lakhdar, 1006 Bab Saadoun, Tunis, Tunisie.
authors.forename: Saloua
authors.initials: S
authors.lastname: Ladeb
authors.forename: Philippe
authors.initials: P
authors.lastname: Gaulard
authors.forename: Tarek
authors.initials: T
authors.lastname: Ben Othmen
authors.forename: Issam
authors.initials: I
authors.lastname: Abd Alsamad
authors.forename: Marie Hélène
authors.initials: MH
authors.lastname: Delfau-Larue
authors.forename: Abderrahmen
authors.initials: A
authors.lastname: Abdelkefi
authors.forename: Lamia
authors.initials: L
authors.lastname: Torjmen
authors.forename: Abdeladhim
authors.initials: A
authors.lastname: Ben Abdeladhim
mesh_terms: D000328:Adult; D001706:Biopsy; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000382:microbiology / Q000473:pathology*; D008297:Male; D015508:Nasal Obstruction / Q000209:etiology; D009669:Nose Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*