title: Cyclosporine excretion into breast milk.
abstract: Although many female patients of childbearing age who are receiving cyclosporine have successful pregnancies, these women may be advised not to breast-feed. During recent years, cases of uneventful pregnancies and subsequent successful breast-feeding have been reported in the literature. The infant's blood cyclosporine concentration was usually very low. Based on these findings and the lack of detectable adverse effects, some investigators have suggested that women on cyclosporine may breast-feed, challenging the conventional view that cyclosporine is contraindicated during breast-feeding. Here, we report our experience with cyclosporine use during breast-feeding in five mother-infant pairs. We show a wide range of infant exposures to the drug in milk, noting that one of the infants had therapeutic blood concentrations of cyclosporine despite relatively low concentrations of the drug in milk.
authors.affiliation: The Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Myla E
authors.initials: ME
authors.lastname: Moretti
authors.forename: Michael
authors.initials: M
authors.lastname: Sgro
authors.forename: David W
authors.initials: DW
authors.lastname: Johnson
authors.forename: Reg S
authors.initials: RS
authors.lastname: Sauve
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Woolgar
authors.forename: Anna
authors.initials: A
authors.lastname: Taddio
authors.forename: Zul
authors.initials: Z
authors.lastname: Verjee
authors.forename: Esther
authors.initials: E
authors.lastname: Giesbrecht
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
authors.forename: Shinya
authors.initials: S
authors.lastname: Ito
mesh_terms: D016572:Cyclosporine / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007231:Infant, Newborn; D016030:Kidney Transplantation / Q000276:immunology*; D008657:Metabolic Clearance Rate; D008895:Milk, Human / Q000276:immunology*; D011247:Pregnancy; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine