Synthesis, characterization, cytotoxic activity, and cellular accumulation of dinuclear platinum complexes derived from N,N'-di-(2-aminoethyl)-1,3-diamino-2-propanol, aryl substituted N-benzyl-1,4-butanediamines, and N-benzyl-1,6-hexanediamines.
This work describes the synthesis and characterization of six new dinuclear platinum complexes having N,N'-di-(2-aminoethyl)-1,3-diamino-2-propanol, aryl substituted N-benzyl-1,4-butanediamines and N-benzyl-1,6-hexanediamines as ligands. They were prepared by the reaction of cis-[PtCl(2)(DMSO)(2)] (DMSO=dimethyl sulfoxide) with the appropriate ligand in water, except for one of them, which was prepared from K(2)PtCl(4). We also report the cytotoxic activity and cellular accumulation of three of these complexes in a human small-cell lung carcinoma cell line and its resistant subline. Resistant cells exhibited a lesser degree of cross-resistance to these compounds when compared to cisplatin. The accumulation of platinum in both cell lines followed the same pattern, i.e. approximately the same intracellular platinum concentration yielded the same cytotoxic effect independent of the nature of the platinum complex used.
Cesar
Elói Teixeira
ET
Colégio de Aplicação João XXIII, Juiz de Fora-MG, Brazil.
de Almeida
Mauro Vieira
MV
Fontes
Ana Paula Soares
AP
Pereira Maia
Elene Cristina
EC
Garnier-Suillerot
Arlette
A
Rúbia Costa Couri
Mara
M
de Castro Antunes Felício
Emanoel
E
D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D019008:Drug Resistance, Neoplasm; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D010984:Platinum / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity*; D011700:Putrescine / Q000031:analogs & derivatives* / Q000737:chemistry*
D008024:Ligands; D009944:Organoplatinum Compounds; C061106:N-benzylputrescine; D010984:Platinum; D011700:Putrescine