GnRH antagonists for treatment of polycystic ovarian syndrome.
To review treatment options for women with polycystic ovary syndrome (PCOS) seeking relief from infertility. Review article and case studies. Treatment options for women with PCOS include lifestyle modification, treatment with insulin-sensitizing agents, ovulation induction with clomiphene citrate (CC), FSH preparations, and possibly, GnRH antagonists. The GnRH antagonists provide a new treatment option for women with PCOS. When the goal is to restore normal ovulation, the use of GnRH antagonists is limited to the prevention of LH surges. When undertaking controlled ovarian hyperstimulation (COH) in women with PCOS, a GnRH antagonist protocol should be the protocol of choice.
Cardone
Vito S
VS
Fertility Center of New England, Reading, Massachusetts 01865, USA. cardonevi@fertilitycenter.com
D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors* / Q000627:therapeutic use*; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects*; D008687:Metformin / Q000627:therapeutic use; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome
D007987:Gonadotropin-Releasing Hormone; D008687:Metformin