title: Convenient preparation and use of a new analytical construct for the analysis and development of solid-phase chemistries.
abstract: An expedient and scalable synthesis of a versatile new analytical construct intermediate 1 is described. The utility of the intermediate 1 is exemplified by the preparation of the construct resin 14 incorporating an acid-labile linker which is used to conveniently develop optimized conditions leading to the preparation of a small compound array 24(1-3,1-3). The optimized conditions are shown to work equally well on both the construct resin 14 and the corresponding base resin 15.
authors.affiliation: GlaxoSmithKline Cambridge Technology Center, University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Andrews
authors.forename: Mark
authors.initials: M
authors.lastname: Ladlow