Separate neural circuits for primary emotions? Brain activity during self-induced sadness and happiness in professional actors.
The question of whether distinct or similar neural substrates underlie primary emotions has not been resolved yet. To address this issue, we used fMRI to scan professional actors during self-induced states of sadness and happiness. Results demonstrated that, relative to an emotionally Neutral state, both the Sad and the Happy states were associated with significant loci of activation, bilaterally, in the orbitofrontal cortex, and in the left medial prefrontal cortex, left ventrolateral prefrontal cortex, left anterior temporal pole, and right pons. These loci of activation were localized distinctly within these regions, that is, in different sub-regions. These results suggest that sadness and happiness may be associated with similar brain regions but distinct sub-regions and neural circuits.
Pelletier
Mario
M
Ventre hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montréal, Canada H3W IW5.
Bouthillier
Alain
A
Lévesque
Johanne
J
Carrier
Serge
S
Breault
Claude
C
Paquette
Vincent
V
Mensour
Boualem
B
Leroux
Jean-Maxime
JM
Beaudoin
Gilles
G
Bourgouin
Pierre
P
Beauregard
Mario
M
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D004532:Ego; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D010104:Oxygen Radioisotopes / Q000493:pharmacokinetics
D010104:Oxygen Radioisotopes