[Study on drug release after arterial embolism with cisplain-loaded albumin microspheres in treating carcinoma of tongue].
OBJECTIVE
The purpose of this study was to investigate the cisplatin release in peripheral blood and tumor tissue after cisplatin-loaded albumin microspheres (CDDP-AMS) were infused through lingual artery for treating carcinoma of tongue.


METHODS
Anticancer agent cisplatin was encapsulated with biodegradable and non-antigenic albumin. The cisplatin-loaded albumin microspheres, which were 56.3 microns in diameter, were used for treating 7 patients with squamous carcinoma of tongue by infusing through lingual artery. The cisplatin in peripheral venous blood and carcinoma tissue were measured for analyzing the drug release in vivo.


RESULTS
Concentration of the drug in peripheral venous blood increased to the highest level in 90 minutes after CDDP-AMS was infused through lingual arterial and still could be detected until 10th day. The cisplatin concentration in tumor tissue kept considerably stable and could be detected until 17 days.


CONCLUSIONS
CDDP-AMS had the effect of controlled release in vive. Effective and steady local drug concentration played the role of killing tumor cells, the low concentration in peripheral blood reduced the side effects of cisplatin to minimum as well. It is concluded that CDDP-AMS is a useful and recommendable method for treating the carcinoma of tongue.
Li
Hongwei
H
West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Wen
Yuming
Y
Wang
Changmei
C
D000328:Adult; D000368:Aged; D000418:Albumins; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000097:blood; D001158:Arteries; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage* / Q000097:blood; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D014059:Tongue / Q000098:blood supply*; D014062:Tongue Neoplasms / Q000188:drug therapy*
D000418:Albumins; D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D002945:Cisplatin