title: Fluorous synthesis of hydantoins and thiohydantoins.
abstract: [reaction: see text] A fluorous synthesis of hydantoins is introduced. The reaction of perfluoroalkyl (Rfh)-tagged amino esters with an isocyanate is followed by the cyclization of ureas and simultaneous cleavage of the fluorous tag to afford hydantoins. The product purification is performed by solid-phase extraction over FluoroFlash cartridges, and no fluorous solvent is involved in either the reaction or the separation processes. The same method applies to synthesis of thiohydantoins.
authors.affiliation: Fluorous Technologies, Inc., University of Pittsburgh Applied Research Center, 970 William Pitt Way, Pittsburgh, Pennsylvania 15238, USA. w.zhang@fluorous.com
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yimin
authors.initials: Y
authors.lastname: Lu
mesh_terms: D006827:Hydantoins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013867:Thiohydantoins / Q000737:chemistry*
chemical_list: D006827:Hydantoins; D013867:Thiohydantoins