Inhibition of benzo(a)pyrene-induced carcinogenesis by vitamin C alone and by vitamin C/vitamin E and selenium/glutathione.
The reduction on peroxidation caused by benzopyrenes by some naturally occurring antineoplastic agents was studied in this experimental work. Inhibition/reduction of experimental carcinogenesis induced by benzo(a)pyrene by vitamin C alone and by vitamin C/vitamin E and selenium/ glutathione was attempted in 224 female Wistar rats divided in four groups. Injected with 10.08 mL benzo(a)pyrene, the animals were treated with some naturally occurring substances like vitamin C alone and a combination of anticarcinogens. By calculating the carcinogenic potency of benzo(a)pyrene and the anticarcinogenic potency of substances used as well as histological examination of developed tumors and survival time of treated animals, it was found that vitamin C exerts a significant anticarcinogenic effect of 8.3 units and that the combination of the two anticarcinogens used produced a significant prolongation of the animals survival time with anticarcinogenic potency of 22.1 and 22.2 units, respectively. This is considered a potent anticarcinogenic effect. The question of an additional supportive administration of such agents complementary to the conventional cancer chemotherapy in humans is raised. Of course, further studies are needed.
Charalabopoulos
K
K
Department of Experimental Physiology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.
Karkabounas
S
S
Charalabopoulos
A K
AK
Papalimneou
V
V
Ioachim
E
E
Giannakopoulos
X
X
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D001580:Benzopyrenes / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced / Q000517:prevention & control; D005978:Glutathione / Q000494:pharmacology*; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*; D016019:Survival Analysis; D014810:Vitamin E / Q000494:pharmacology*
D000970:Antineoplastic Agents; D001580:Benzopyrenes; D014810:Vitamin E; D005978:Glutathione; D012643:Selenium; D001205:Ascorbic Acid