title: Report of a renal transplanted patient with fibroadenoma occurring in a short time.
abstract: The incidence of breast cancer in renal transplant patients is similar to that of general population. But fibroadenomas may be seen as a result of exposure to cyclosporine (CyA). Herein we report the case of a 32-year-old woman who received a renal transplant and had a breast fibroadenoma. She had been prescribed CyA, azathioprine, and steroids for 4 years. At the end of the first year a palpable mass had been detected in her right breast; the pathologic diagnosis was fibroadenoma. At the 4th year after transplantation, immunosuppressive treatment was switched to CyA and mycopholate mofetil (MMF) because of an increased serum creatinine level. Two years later seven breast nodes from both breasts were detected by ultrasonography. Totally excision was performed revealing a histopathologic diagnosis of fibroademata as before. In this case, the combination of CyA and MMF administration seemed to cause an increase in the number of nodules in a short time. The cause of fibroadenomas may be related to drug-induced secretion of proliferative or anti-apoptotic cytokines.
authors.affiliation: Cukurova University, Medical Faculty, Department of Nephrology, Adana, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Balal
authors.forename: N
authors.initials: N
authors.lastname: Seyrek
authors.forename: I
authors.initials: I
authors.lastname: Karayaylali
authors.forename: S
authors.initials: S
authors.lastname: Paydas
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000601:surgery; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D018226:Fibroadenoma / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000009:adverse effects*; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000175:diagnosis; D013256:Steroids / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D013256:Steroids; D016572:Cyclosporine; D003404:Creatinine; D009173:Mycophenolic Acid; D001379:Azathioprine