Going to the well no more: lawn format assays for ultra-high-throughput screening.
Screening in a 'well-less' or lawn format provides a means to screen large compound collections against many targets in a fast, versatile and cost effective manner. The development of generic lawn format assays to screen various gene families against large compound collections should facilitate the identification of hits and tools to use in drug discovery and chemogenomic endeavours. Lawn format holds particular promise for screening GPCRs and selected enzyme families with potential use in other gene families.
Marron
Brian E
BE
Icagen Inc., 4222 Emperor Blvd, Suite 390, Durham NC 27703, USA. bmarron@icagen.com
Jayawickreme
Channa K
CK
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002478:Cells, Cultured; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004798:Enzymes / Q000737:chemistry; D006801:Humans; D011485:Protein Binding
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D004798:Enzymes