title: Beta-pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytes.
abstract: We previously found that drinking beer reduces chromosome aberrations in blood lymphocytes that were collect and irradiated in vitro. In this study, human whole-blood was in vitro exposed to 200kVp X-rays or 50keV/microm carbon ions in the presence or absence of beer, ethanol and beta-pseudouridine (one of the beer components). All three agents reduced the chromosome aberrations (dicentric) caused by either X-rays or carbon ions of 4Gy. The maximum protection for X-rays by ethanol, beer and beta-pseudouridine was 64, 26 and 34%, respectively, while the maximum protection for carbon-ion by ethanol, beer and beta-pseudouridine was 22, 26 and 32%, respectively. It is concluded that beta-pseudouridine, a nucleoside present in tRNA, is a potent protector against damage caused by radiation with direct and indirect actions.
authors.affiliation: Division of Heavy-ion Radiobiology Research Group, National Institute of Radiological Sciences, Chiba, Japan. monobe@nirs.go.jp
authors.forename: Manami
authors.initials: M
authors.lastname: Monobe
authors.forename: Sakae
authors.initials: S
authors.lastname: Arimoto-Kobayashi
authors.forename: Koichi
authors.initials: K
authors.lastname: Ando
mesh_terms: D016587:Antimutagenic Agents / Q000494:pharmacology*; D001515:Beer / Q000032:analysis; D002244:Carbon; D002869:Chromosome Aberrations / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D007477:Ions; D018499:Linear Energy Transfer; D008214:Lymphocytes / Q000187:drug effects* / Q000528:radiation effects*; D016296:Mutagenesis; D011560:Pseudouridine / Q000494:pharmacology*; D011832:Radiation Injuries / Q000517:prevention & control*; D014965:X-Rays
chemical_list: D016587:Antimutagenic Agents; D007477:Ions; D011560:Pseudouridine; D000431:Ethanol; D002244:Carbon