Trichinella britovi human infection in Spain: antibody response to surface, excretory/secretory and somatic antigens.
A third outbreak of Trichinella britovi with 140 people involved, occurred in Granada Spain (December 1998). The source of infection was sausage made from uninspected wild boar meat. Fifty-two patients agreed to participated in this study. An elevated eosinophil level (> 5%) was detected in 59.6% of patients, and persisted in most of these cases for two months. A moderate IgG response was observed. At the onset of symptoms, Western blot (WB) test detected more positive cases than Enzyme linked immunosorbent assay (ELISA) and indirect immunofluorescence (IIF). Six months from infection, ELISA revealed fewer positive cases than the other two tests. It would appear that the response to somatic antigens starts earlier than those to cuticular and excretory/secretory (ES) antigens and that the response to ES antigens is the first to decrease.
Rodríguez-Osorio
M
M
Departamento de nutrición animal, Estación experimental del Zaidín, Consejo superior de investigaciones científicas (CSIC), Profesor Albareda 1, Granada, 18008, Spain. mrosorio@eez.csic.es
Gómez-Garcia
V
V
Benito
R
R
Gil
J
J
D000293:Adolescent; D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis* / Q000097:blood; D000947:Antigens, Helminth / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D015153:Blotting, Western / Q000379:methods; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect / Q000379:methods; D016266:Food Parasitology; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood; D008297:Male; D008461:Meat Products / Q000469:parasitology; D008875:Middle Aged; D013030:Spain / Q000453:epidemiology; D013552:Swine; D014234:Trichinella / Q000276:immunology*; D014235:Trichinellosis / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D000954:Antigens, Surface; D007074:Immunoglobulin G