Polymicrogyria in monozygous twins and an elder sibling.
Monozygous twin births have been associated with brain lesions such as hydranencephaly, multicystic encephalomalacia, and porencephaly. Prenatal circulatory injury has been considered to be the cause. Polymicrogyria is rare but has been reported in autopsied cases. The sibship in this case report, comprising monozygotic male twins and their elder sister from the same non-consanguineous parents, all had global developmental delay. Brain MRI showed polymicrogyria. We suggest that, apart from circulatory compromise, genetic etiology must be implicated as the cause of polymicrogyria.
Hung
Po-Cheng
PC
Division of Pediatric Neurology, Chang Gung Children's Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan. hongfh@ms14.hinet.net
Wang
Huei-Shyong
HS
D001921:Brain / Q000002:abnormalities*; D002540:Cerebral Cortex / Q000002:abnormalities; D004200:Diseases in Twins / Q000175:diagnosis* / Q000235:genetics; D005192:Family Health; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D035781:Siblings; D014430:Twins, Monozygotic / Q000235:genetics