[Posterior reversible encephalopathy syndrome: about 2 cases related to the cyclosporine].
Following a pulmonary transplantation for cystic fibrosis, 2 patients exhibited a syndrome associating arterial hypertension, headache, visual trouble and generalized seizures. Cerebral magnetic resonance imaging revealed diffuse cortical and subcortical lesions predominantly in posterior regions. The exclusion of alternate diagnoses and the disappearance of the symptoms when the cyclosporine treatment was stopped confirmed the diagnosis of cyclosporine-related reversible posterior encephalopathy syndrome (PRES). Immediate appropriate management resulted in symptom disappearance and regression of radiological images.
Lepoivre
T
T
Service d'anesthésie et de réanimation chirurgicale, hôpital G. et R.-Laennec, 44093 cedex 1, Nantes, France. thierry.lepoivre@club-internet.fr <thierry.lepoivre@club-internet.fr>
Treilhaud
M
M
Auffray-Calvier
E
E
Rigal
J C
JC
Blanloeil
Y
Y
D000328:Adult; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology; D016572:Cyclosporine / Q000009:adverse effects*; D006261:Headache / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016040:Lung Transplantation / Q000009:adverse effects / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D012640:Seizures / Q000150:complications; D013577:Syndrome
D007166:Immunosuppressive Agents; D016572:Cyclosporine