Tumor necrosis factor expression in arterial walls of diabetic rats.
Immunohistochemistry was used to detect tumor necrosis factor (TNF-alpha) expression in arterial wall of diabetic rats. It was found that endothelial cells were swollen and markedly proliferative in these vessels and accordingly TNF-alpha showed strong positive immunohistochemical reaction in endothelial cells or extracellular intimal matrix of such vessels, which might be caused by the expression and release of TNF-alpha from monocytes and arterial wall cells stimulated by AGEs. These findings suggested that increased TNF-alpha expression might be associated with vascular damage and remodeling in diabetes.
Zhang
M
M
Department of Endocrinology, Tongji Hospital, Tongji Medical University, Wuhan 430030.
Ren
D
D
Li
X
X
Zhang
J
J
D000818:Animals; D001160:Arterioles / Q000166:cytology / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism*; D008297:Male; D017538:Mesenteric Artery, Superior / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000235:genetics
D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha