title: A new putative G-protein coupled receptor gene associated with the immune system of rainbow trout (Oncorhynchus mykiss).
abstract: A putative G-protein coupled receptor (GPCR) gene belonging to the rhodopsin-like family was detected in rainbow trout and designated LPSenhR-1. Only moderate homology (<35%) was present with known GPCRs. Semi-quantitative RT-PCR indicated that the gene was expressed predominantly in lymphoid tissues, with highest expression associated with cells of the monocyte/macrophage lineage. Expression was strongly up-regulated by injection with LPS but not by infection with infectious haematopoietic necrosis virus.
authors.affiliation: Inland Station/National Research Institute of Aquaculture, Fisheries Research Agency, Tamaki, Mie, 519-0423, Japan.
authors.forename: Ikunari
authors.initials: I
authors.lastname: Kiryu
authors.forename: Bernd
authors.initials: B
authors.lastname: Köllner
authors.forename: Akashi
authors.initials: A
authors.lastname: Kuroda
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Ototake
authors.forename: Johannes Martinus
authors.initials: JM
authors.lastname: Dijkstra
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018175:Birnaviridae Infections / Q000276:immunology / Q000662:veterinary / Q000821:virology; D019204:GTP-Binding Proteins / Q000235:genetics / Q000276:immunology*; D018061:Infectious pancreatic necrosis virus / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D008221:Lymphoid Tissue / Q000276:immunology; D008969:Molecular Sequence Data; D017686:Oncorhynchus mykiss / Q000235:genetics / Q000276:immunology*; D012313:RNA / Q000737:chemistry / Q000235:genetics; D019105:Random Amplified Polymorphic DNA Technique / Q000662:veterinary; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology*; D015854:Up-Regulation / Q000276:immunology
chemical_list: D008070:Lipopolysaccharides; D011971:Receptors, Immunologic; D012313:RNA; D019204:GTP-Binding Proteins