Free radical disease prevention and nutrition.
An improved antioxidant status (overthreshold plasma values of essential antioxidants) minimizes the oxidative damage. The levels of antioxidant vitamins C and E, ,,antioxidant" trace elements selenium, zinc, copper and iron were measured in two groups of adults with different nutritional habits--alternative (vegetarians; n=110) and traditional (mixed diet, control, n=101). The prevalence of iron and zinc deficiencies was found in the alternative group (20% vs 11%--iron, 13% vs 9%--zinc) as a consequence of higher intake of plant trace element absorption inhibitors. As opposed to the latter, the control group had higher findings of iron and copper levels over the optimal range (18% vs 8%--iron, 11% vs 2%--copper). The subjects on mixed diet was showed a significant negative linear correlation between serum zinc and iron levels. This favourable relationship means a decrease in Fenton reaction by indirect zinc effect. Average plasma values of vitamin C, vitamin C/vitamin E, vitamin E/ cholesterol (LDL protection), vitamin E/triacylglycerols (polyunsaturated fatty acid protection) in vegetarians are over the threshold with high number of individual overthreshold values (94% vs 17%--vitamin C, 100% vs 58%--vitamin C/vitamin E, 89% vs 68%--vitamin E/cholesterol, 100% vs 64%--vitamin E/triacylglycerols). Homocysteine levels in vegetarians (36% atherogenic levels) correlate significantly inversely to vitamin C levels, the fact of which means a positive vitamin C effect in free radical remove also in hyperhomocysteinemia. Plant food is a rich source of antioxidants. A correct vegetarian nutrition or optimized mixed diets with regular and frequent consumption of protective food commodities may be an effective contribution to the age-related chronic degenerative disease prevention. (Tab. 2, Fig. 2, Ref. 31.).
Krajcovicova-Kudlackova
M
M
Institute of Preventive and Clinical Medicine, Bratislava, Slovakia. Kudlackova@upkm.sk
Ursinyova
M
M
Blazicek
P
P
Spustova
V
V
Ginter
E
E
Hladikova
V
V
Klvanova
J
J
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D002318:Cardiovascular Diseases / Q000517:prevention & control; D004032:Diet; D014676:Diet, Vegetarian; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D014131:Trace Elements / Q000097:blood; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D005609:Free Radicals; D014131:Trace Elements; D006710:Homocysteine; D014810:Vitamin E; D001205:Ascorbic Acid