title: Uniformly sized molecularly imprinted polymer for d-chlorpheniramine. Evaluation of retention and molecular recognition properties in an aqueous mobile phase.
abstract: A uniformly sized molecularly imprinted polymer (MIP) for d-chlorpheniramine has been prepared by a multi-step swelling and polymerization method using methacrylic acid and ethylene glycol dimethacrylate as a functional monomer and cross-linker, respectively. The retentive and enantioselective properties of chlorpheniramine and its structurally related compounds on the MIP were evaluated using an aqueous mobile phase. Electrostatic and hydrophobic interactions could mainly work for the retention and enantioseparation of chlorpheniramine in aqueous mobile phase. Further, the MIP showed the highest recognition for chlorpheniramine and slight recognition for its structurally related compounds, and enantioseparation of pheniramine was attained.
authors.affiliation: Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo 663-8179, Japan. haginaka@mwu.mukogawa-u.ac.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Haginaka
authors.forename: Chino
authors.initials: C
authors.lastname: Kagawa
mesh_terms: D002744:Chlorpheniramine / Q000032:analysis* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D003432:Cross-Linking Reagents; D006634:Histamine H1 Antagonists / Q000032:analysis* / Q000302:isolation & purification; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates; D011108:Polymers; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D003432:Cross-Linking Reagents; D006634:Histamine H1 Antagonists; D008689:Methacrylates; D011108:Polymers; C008384:methacrylic acid; D002744:Chlorpheniramine; C004919:ethylene dimethacrylate