title: [Immunomodulating effect of short-term deep local cooling and its enhancement with vitamin A].
abstract: Local cooling (LC) of the Wistar rat's foot to -120 degrees for 10 or 20 sec stimulates development of humoral immune response and delayed hypersensitivity induced by sheep erythrocytes. A stimulating action of short-term LC can be enhanced by introduction of retinol acetate into the cooling zone. The immunostimulating effect of short-term LC and retinal acetate is mediated by cytokines released by the cells of regional lymph nodes.
authors.forename: A R
authors.initials: AR
authors.lastname: Avakian
authors.forename: I L
authors.initials: IL
authors.lastname: Brovkina
authors.forename: A I
authors.initials: AI
authors.lastname: Lazarev
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000502:physiology*; D003080:Cold Temperature; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D004224:Diterpenes; D004912:Erythrocytes / Q000276:immunology; D005121:Extremities / Q000502:physiology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007036:Hypothermia, Induced / Q000009:adverse effects*; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D000084562:Retinyl Esters; D012756:Sheep; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D016207:Cytokines; D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate