title: The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor.
abstract: Nearly one-third of Krupple-type C2H2 zinc finger proteins have a krupple-associated box (KRAB) domain, which may act as a transcriptional repressor. ZNF268, which was novelty isolated from early human embryo, is a typical krupple-type C2H2 zinc finger protein with a conserved KRAB domain. In this report, the KRAB domain of ZNF268 is identified to localize in the nucleus and has transcriptional repressor activity.
authors.affiliation: College of Life Sciences, Wuhan University, Wuhan 430072, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: De-ming
authors.initials: DM
authors.lastname: Gou
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Xiao
authors.initials: X
authors.lastname: Peng
authors.forename: Wen-xin
authors.initials: WX
authors.lastname: Li
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D016384:Consensus Sequence; D017124:Conserved Sequence; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D004622:Embryo, Mammalian; D006801:Humans; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D012097:Repressor Proteins / Q000737:chemistry / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic; D016335:Zinc Fingers
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D011993:Recombinant Fusion Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C482295:ZNF268 protein, human