Enhancer regulation/endogenous and synthetic enhancer compounds: a neurochemical concept of the innate and acquired drives.
This review is to summarize experimental evidence and theoretical consideration in support of the concept that a mesencephalic enhancer regulation is the basis of the limited number of innate drives indispensable for the survival of the individual and the species, while a specifically organized telencephalic enhancer regulation is the basis of the acquired drives to reach an unlimited number of dispensable goals. The study is also an overview of the experimental and clinical data supporting the proposal that, due to the progressive decay of the mesencephalic enhancer regulation with the passing of time, the prophylactic administration of a synthetic enhancer substance [(-)-deprenyl, (-)-BPAP] during postdevelopmental life could significantly slow the age-related decay of behavioral performances, prolong life, and prevent the precipitation or delay the onset of Parkinson's disease and Alzheimer's disease.
Knoll
Joseph
J
Department of Pharmacology and Pharmacotherapy, Faculty of General Medicine, Semmelweis University, POB 370, H-1445 Budapest, Hungary. jozsefknoll@hotmail.com
D018697:Nootropic Agents / Q000494:pharmacology*; D012642:Selegiline / Q000494:pharmacology*
D018697:Nootropic Agents; D012642:Selegiline