Recognition of the DNA minor groove by pyrrole-imidazole polyamides.
Many diseases, such as cancer, are related to aberrant gene expression. Regulating transcription by chemical methods could be important in human medicine. Minor groove-binding polyamides offer one chemical approach to DNA recognition.
Dervan
Peter B
PB
Division of Chemistry and Chemical Engineering, and Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA. dervan@cco.caltech.edu
Edelson
Benjamin S
BS
D001483:Base Sequence; D001562:Benzimidazoles / Q000378:metabolism; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D007093:Imidazoles / Q000378:metabolism; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009757:Nylons / Q000378:metabolism*; D011758:Pyrroles / Q000378:metabolism
D001562:Benzimidazoles; D004268:DNA-Binding Proteins; D007093:Imidazoles; D009757:Nylons; D011758:Pyrroles; C029899:imidazole; D004247:DNA