The adult hemopoietic stem cell plasticity debate: idols vs new paradigms.
The debate surrounding adult stem cell plasticity derives from a confusion regarding definitions of important terms and the identification of key questions. After defining plasticity, lineage, differentiation and transdifferentiation, the authors put forth a framework for future dialogue as well as their perspective on the stem cell plasticity debate.
Moore
B E
BE
Roger Williams Medical Center, Center for Stem Cell Biology, Providence, Rhode Island 02908-4735, USA.
Quesenberry
P J
PJ
D000818:Animals; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D019070:Cell Lineage; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D051379:Mice; D009474:Neurons / Q000166:cytology