title: Polypoid S-100-negative granular cell tumor of the oral cavity: a case report and review of literature.
abstract: This is a report of a case of an S-100-negative polypoid granular cell tumor arising in the lower lip of a 4-year-old patient that may represent the entity primitive polypoid granular cell tumor. Unlike the usual granular cell tumors arising in the tongue or buccal mucosa, such lesions are not S-100 positive and can exhibit mitoses and cytologic atypia, features that may suggest a low-grade mesenchymal malignancy necessitating aggressive therapy. However, this is in fact a nonaggressive neoplasm that is not associated with significant morbidity and therefore should be treated with simple excision.
authors.affiliation: Department of Oral Medicine and Diagnostic Sciences, Harvard Dental School, Harvard University, Boston, MA 02115, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Basile
authors.forename: Sook-Bin
authors.initials: SB
authors.lastname: Woo
mesh_terms: D002675:Child, Preschool; D005260:Female; D016586:Granular Cell Tumor / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D008048:Lip Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D009418:S100 Proteins / Q000032:analysis
chemical_list: D009418:S100 Proteins