title: [Mucosal damage caused by nonsteroidal anti-inflammatory agents in H. pylori infection].
abstract: BACKGROUND
  The pathogenic role of Helicobacter pylori (H. pylori) infection in the setting of NSAID use is still controversial. Aim of the study is to prove increased incidence of gastric mucosa damage in H. pylori positive NSAID users compared to H. pylori negative patients.
  
  
  METHODS
  Patients with dyspeptic symptoms (n = 160, average age 62.13 +/- 6.24, ranged from 51 to 77 years) were divided in two groups: 80 patients (45 male, 35 female) with positive history of using NSAID and same group with negative history for NSAID. All patients underwent endoscopy, examined to H. pylori presence by rapid unease test. Patients with ulcer or erosions (> 5) were evaluated and grade of gastric mucosa damage were done according to Forrest classification of gastrointestinal bleeding.
  
  
  RESULTS
  In first group 69/80 of examined patients were H. pylori positive, in second group 56/80 were H. pylori positive (X2 = 5.266; p = 0.022). In gastric mucosa bleeding, caused with NSAIDs, H. pylori was not diagnosed more often compared to other group (p > 0.05).
  
  
  CONCLUSIONS
  Patients with NSAID induced gastric injury were significantly greater incidence of H. pylori infection compared to patients without history of NSAIDs abuse. H. pylori was not significantly present in complication of ulcer disease (bleeding) caused by NSAID.
authors.affiliation: Klinika za gastroenterohepatologiju, Klinicki centar Univerziteta Sarajevo, Bosna i Hercegovina.
authors.forename: Nenad
authors.initials: N
authors.lastname: Vanis
authors.forename: Mehmed
authors.initials: M
authors.lastname: Gribajcević
authors.forename: Nada
authors.initials: N
authors.lastname: Borovac
authors.forename: Rusmir
authors.initials: R
authors.lastname: Mesihović
authors.forename: Srdan
authors.initials: S
authors.lastname: Gornjaković
authors.forename: Nada
authors.initials: N
authors.lastname: Zubcević
authors.forename: Aida
authors.initials: A
authors.lastname: Pilav
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D016481:Helicobacter Infections / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal