title: Staging of advanced cervical carcinoma using MRI-predictors of outcome after radical radiotherapy.
abstract: OBJECTIVE
  To assess the prognostic significance of imaging findings used in magnetic resonance imaging (MRI) staging of cervical carcinoma by correlation with survival after radiotherapy.
  
  
  METHODS
  MRI examinations of 99 cervical carcinoma patients were reviewed. Tumour involvement of pelvic structures was assessed. Lymph node sites, short axis diameters and signal characteristics were recorded. MRI staging was compared with clinical [International Federation of Gynaecology and Obstetrics (FIGO)] staging. Univariate analysis was performed for MRI stage, clinical stage, nodal status and pelvic structure involvement against disease-specific (DSS) and disease-free survival (DFS).
  
  
  RESULTS
  MRI staging correlated with DSS (p=0.006) and DFS (p=0.007) but clinical staging did not. Pelvic nodes > or = 10 mm and juxtaregional or distant nodes > or = 8 mm short axis were most strongly associated with survival (p=0.014, p=0.011 and p=0.001, respectively, for association with DSS). Tumour involvement of pelvic bowel loops, pelvic sidewall and bladder mucosa were significantly associated with poor DSS and DFS (p<0.05). Tumour dimensions and bladder muscle involvement alone were not associated with poor survival.
  
  
  CONCLUSIONS
  MRI staging is a better predictor of survival than clinical staging in patients receiving radiotherapy for cervical carcinoma. MRI assessment of lymph node enlargement and tumour involvement of pelvic structures gives valuable prognostic information.
authors.affiliation: Department of Diagnostic Radiology, Christie Hospital NHS Trust, Wilmslow Road, Withington, M20 4BX, Manchester, UK. ben.taylor@christie-tr.nwest.nhs.uk
authors.forename: M B
authors.initials: MB
authors.lastname: Taylor
authors.forename: B M
authors.initials: BM
authors.lastname: Carrington
authors.forename: S E
authors.initials: SE
authors.lastname: Davidson
authors.forename: R
authors.initials: R
authors.lastname: Swindell
authors.forename: J A L
authors.initials: JA
authors.lastname: Lawrance
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000532:radiotherapy