Host immune responses against hog cholera virus in pigs treated with an ionized alkali mineral complex.
To determine the immune responses in pigs to hog cholera virus after treatment with an ionized alkali mineral complex (IAMC), 40 healthy pigs (28-32 days old) from a commercial swine farm were purchased and housed into 4 groups (n=10 each). All pigs were vaccinated intramuscularly (1 ml) with an attenuated live hog cholera virus (HCV, LOM strain) at 28-32 days old and challenged with a virulent hog cholera virus at 8 weeks after vaccination. Each group was treated with PowerFeel sprayed diet as 0.05% (w/w) in a final concentration (T-1, n=10), a diet mixed with SuperFeed as 3% (w/w) in a final concentration (T-2, n=10), or a diluted PowerFeel solution (1:500, v/v) as drinking water (T-3, n=10), respectively. A group (n=10) served as a non-treated control. Proportions of expressing CD2+ and CD8+ cells increased significantly (p<, 0.05) at 8-week post-application. Mean antibody titers of each group against HCV gradually increased to higher levels after vaccination and with challenge of the virulent virus. In conclusion, the IAMC-treated diets can be helpful for the improvement of growth in pigs with proper vaccination program, while the IAMC-treated diets have no effects on the clinical protection against hog cholera.
Park
Bong-Kyun
BK
College of Veterinary Medicine, Seoul National University, 441-744 Suwon, Korea. parkx026@snu.ac.kr
Lyoo
Kwang-Soo
KS
Park
Yong-Ho
YH
Koh
Jong-Ho
JH
Seo
KyungSuk
K
D000468:Alkalies / Q000276:immunology / Q000494:pharmacology*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D006691:Classical Swine Fever / Q000276:immunology* / Q000517:prevention & control; D006692:Classical Swine Fever Virus / Q000276:immunology*; D005434:Flow Cytometry / Q000662:veterinary; D019084:Fluorescent Antibody Technique, Indirect / Q000662:veterinary; D006680:HLA Antigens / Q000276:immunology; D008903:Minerals / Q000276:immunology / Q000494:pharmacology*; D013552:Swine; D014611:Vaccination / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
D000468:Alkalies; D000914:Antibodies, Viral; D006680:HLA Antigens; D008903:Minerals; D014613:Vaccines, Attenuated; D014765:Viral Vaccines