Live birth rate varies with gestational history and etiology in women experiencing recurrent spontaneous abortion.
OBJECTIVE
The aims of this study were to assess pregnancy outcome in relation to etiologic factors of recurrent spontaneous abortion (RSA).


METHODS
The pregnancies from consecutive 216 RSA women were assessed for live birth rates (LBR) according to etiology. The LBR in 110 pregnancies from RSA women with unexplained etiology was investigated according to various therapies. An attempt to karyotype the abortuses was made.


RESULTS
Excluding pregnancies ending in abortion with abnormal karyotype, the LBR in primary recurrent spontaneous aborters (68.8%) who experienced three or more abortions was significantly lower than that in primary repeated aborters (82.4%) who experienced two abortions. The LBR ranged from 50 to 100% according to the etiology. In RSA women with unexplained etiology, the LBR in those undergoing massive intravenous immunoglobulin (MIVIg) therapy (100%) was significantly higher than those with low dose aspirin (57.1%) and luteal support therapy (67.3%).


CONCLUSIONS
Excluding pregnancies ending in abortion with abnormal karyotype, we found that LBR varied with abortion history and etiologic factors of RSA.
Morikawa
Mamoru
M
Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Kita-ku N15 W7, Sapporo 060 8638, Japan.
Yamada
Hideto
H
Kato
Emi H
EH
Shimada
Shigeki
S
Sakuragi
Noriaki
N
Fujimoto
Seiichiro
S
Minakami
Hisanori
H
D000026:Abortion, Habitual / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D001241:Aspirin / Q000008:administration & dosage; D002869:Chromosome Aberrations; D003338:Corpus Luteum; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007621:Karyotyping; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate
D016756:Immunoglobulins, Intravenous; D001241:Aspirin