title: Quantitative analysis of cortical pyramidal neurons after corpus callosotomy.
abstract: This study quantitatively explored the dendritic/spine extent of supragranular pyramidal neurons across several cortical areas in two adult male subjects who had undergone a callosotomy several decades before death. In all cortical areas, there were numerous atypical, supragranular pyramidal neurons with elongated "tap root" basilar dendrites. These atypical cells could be associated with an underlying epileptic condition and/or could represent a compensatory mechanism in response to deafferentation after callosotomy.
authors.affiliation: Laboratory of Quantitative Neuromorphology, Department of Psychology, Colorado College, Colorado Springs, CO 80903, USA. bjacobs@coloradocollege.edu
authors.forename: Bob
authors.initials: B
authors.lastname: Jacobs
authors.forename: Johanna
authors.initials: J
authors.lastname: Creswell
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Britt
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Ford
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Bogen
authors.forename: Eran
authors.initials: E
authors.lastname: Zaidel
mesh_terms: D000293:Adolescent; D000328:Adult; D002452:Cell Count; D003337:Corpus Callosum / Q000601:surgery*; D003712:Dendrites / Q000648:ultrastructure; D004829:Epilepsy, Generalized / Q000601:surgery; D005625:Frontal Lobe / Q000648:ultrastructure; D006801:Humans; D008297:Male; D009474:Neurons / Q000648:ultrastructure; D019635:Neurosurgical Procedures / Q000379:methods; D011184:Postoperative Period; D017966:Pyramidal Cells / Q000648:ultrastructure*