A potential proteasome-interacting motif within the ubiquitin-like domain of parkin and other proteins.
Parkin and other unrelated proteins contain a ubiquitin-like domain (UbLD). This article describes a motif that might be important in the interaction of UbLD-containing proteins (UbLPs) with the proteasome. The proteasome-interacting motif, which is conserved in a subset of UbLPs, such as parkin, Rad23 and several transcription factors, is likely to enable the UbLPs to form a complex with the proteasome for proteolysis or the recently discovered non-proteolytic functions of the proteasome.
Upadhya
Sudarshan C
SC
Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Hegde
Ashok N
AN
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D004260:DNA Repair; D045643:DNA Repair Enzymes; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008025:Ligases / Q000378:metabolism*; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D010802:Phylogeny; D046988:Proteasome Endopeptidase Complex; D017386:Sequence Homology, Amino Acid; D044767:Ubiquitin-Protein Ligases; D014452:Ubiquitins / Q000378:metabolism*
D004268:DNA-Binding Proteins; D009097:Multienzyme Complexes; D014452:Ubiquitins; C086985:RAD23A protein, human; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D010447:Peptide Hydrolases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; D008025:Ligases; D045643:DNA Repair Enzymes