Relationship between histopathologic gastritis and mucosal microvascularity: observations with magnifying endoscopy.
BACKGROUND
The purpose of this study was to determine the usefulness of magnifying endoscopy for the diagnosis of Helicobacter pylori-induced histopathologic gastritis.


METHODS
A total of 92 patients scheduled to undergo routine endoscopic examination were enrolled. After routine endoscopic examination, 3 sites in the stomach were studied by magnified observation. Visualized collecting venulae were classified into the following 3 patterns: regular, irregular, and obscured. The sites observed by magnifying endoscopy were assessed histopathologically with an Updated Sydney System; 4 morphologic parameters (activity, inflammation, atrophy, metaplasia) were assessed and graded from 0 to 3.


RESULTS
The regular pattern cases were negative for H pylori infection at all sites observed by magnifying endoscopy (antrum greater curve, 0/11; body greater curve, 0/24; body lesser curve, 0/23). The scores for all 4 morphologic parameters were significantly lower in the regular pattern group than the irregular and obscured groups (p < 0.01). The value of the atrophy parameter in the irregular group was significantly higher than that in the obscured group (p < 0.05 for a single test of hypothesis; correction for multiple testing of data removed significance).


CONCLUSIONS
Visibility of collecting venulae in the gastric mucosa is influenced by H pylori-induced histopathologic gastritis. Magnifying endoscopy is useful for the diagnosis of histopathologic gastritis.
Nakagawa
Souichi
S
Department of Gastroenterology and Division of Endoscopy, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Kato
Mototsugu
M
Shimizu
Yuichi
Y
Nakagawa
Manabu
M
Yamamoto
Junji
J
Luis
Perez Aldana
PA
Kodaira
Junichi
J
Kawarasaki
Mitsuru
M
Takeda
Hirosh
H
Sugiyama
Toshiro
T
Asaka
Masahiro
M
D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000098:blood supply* / Q000473:pathology; D005756:Gastritis / Q000382:microbiology / Q000473:pathology*; D005773:Gastroscopy / Q000379:methods*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000473:pathology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011336:Probability; D011446:Prospective Studies; D011858:Radiographic Magnification; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index