title: Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis.
abstract: Four new ent-kaurane diterpenoids lushanrubescensins F-I (1-4), together with 11 known ones, lasiodonin (5), oridonin (6), ponicidin (7), isodonoiol (8), isodonal (9), rabdosin B (10), rabdoternins A and B (11 and 12), enmenol (13), epinodosin (14), and inflexusin (15), were isolated from Isodon rubescens var. lushanensis, and the structures were elucidated by spectroscopic analysis. The inhibitory effect against the K562, Bcap37, BGC823, BIU87, CA, CNE, and Hela cell lines of compounds 3 and 5-10 were evaluated.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Ma-Lin
authors.initials: ML
authors.lastname: Li
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Yi-Kun
authors.initials: YK
authors.lastname: Mou
authors.forename: Zhong-Wen
authors.initials: ZW
authors.lastname: Lin
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D037602:Isodon; D020014:K562 Cells; D000091402:Prohibitins
chemical_list: D004224:Diterpenes; D045786:Diterpenes, Kaurane; C000717331:PHB2 protein, human; D000091402:Prohibitins