title: Distribution of methyl sulfone metabolites of polychlorinated biphenyls and p,p'-DDE in human tissues.
abstract: We determined methylsulfonyl metabolites of chlorinated biphenyls (MeSO2-CBs) and 1,1-bis(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE) in human adipose, liver, brain, and lung tissues obtained from 11 Belgian individuals (9-62 years of age). The total concentration of MeSO2-CBs (lipid weight basis) decreased in the following order: liver (mean, 9.30 ng/g; range, 1.68-27.03 ng/g lipid) > lung [mean, 2.72 ng/g; range, not detected (ND) to 11.54 ng/g lipid] > adipose tissue (mean, 1.57 ng/g; range, 0.33-4.33 ng/g lipid) > brain (mean, 0.24 ng/g; range, ND-0.56 ng/g lipid). The profiles of MeSO2-CBs and MeSO2-DDE in each tissue were similar for all 11 subjects. In adipose, brain, and lung tissues, 4'-MeSO2-CB87, 4'-MeSO2-CB101, and 3-MeSO2-CB149 (except brain) occurred at higher concentrations than did other MeSO2-CBs. However, 3'-MeSO2-CB132 was by far the most abundant congener in liver, contributing on average to approximately 60% of the sum of MeSO2-CBs. The concentrations of 3-MeSO2-DDE in different tissues were at the same or lower levels than the total concentrations of MeSO2-CBs. This study suggests that the distribution patterns of MeSO2-CBs and MeSO2-DDE in humans differ between liver and other tissues. Moreover, these profiles differ from those found in other mammals, such as polar bears, porpoises, and otters.
authors.affiliation: Toxicological Center, University of Antwerp, Wilrijk, Belgium.
authors.forename: Shaogang
authors.initials: S
authors.lastname: Chu
authors.forename: Adrian
authors.initials: A
authors.lastname: Covaci
authors.forename: Werner
authors.initials: W
authors.lastname: Jacobs
authors.forename: Koichi
authors.initials: K
authors.lastname: Haraguchi
authors.forename: Paul
authors.initials: P
authors.lastname: Schepens
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000293:Adolescent; D000328:Adult; D001923:Brain Chemistry; D002648:Child; D003633:Dichlorodiphenyl Dichloroethylene / Q000032:analysis / Q000378:metabolism / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007306:Insecticides / Q000032:analysis / Q000378:metabolism / Q000493:pharmacokinetics*; D008099:Liver / Q000737:chemistry; D008168:Lung / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000378:metabolism / Q000493:pharmacokinetics*; D013450:Sulfones / Q000032:analysis / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D007306:Insecticides; D013450:Sulfones; D003633:Dichlorodiphenyl Dichloroethylene; D011078:Polychlorinated Biphenyls