title: Longitudinal study of cervical squamous intraepithelial lesions in human immunodeficiency virus (HIV)-seropositive and at-risk HIV-seronegative women.
abstract: We examined incidence and correlates of progression and regression of abnormal cervical cytologic test results, defined as at least low-grade squamous intraepithelial lesions (SILs), in 774 human immunodeficiency virus (HIV)-seropositive and 391 HIV-seronegative women monitored semiannually for up to 5.5 years. During follow-up, 224 (35%) HIV-seropositive women and 34 (9%) HIV-seronegative women had incident SILs detected by Pap test; 47 (7%) HIV-seropositive women developed high-grade lesions. The incidence of SILs was 11.5 cases among HIV-seropositive and 2.6 cases among HIV-seronegative women per 100 person-years of observation (rate ratio, 4.5; 95% confidence interval, 3.1-6.4; P<.001). Risk of incident SILs and likelihood of Pap test progression were increased among HIV-seropositive women with CD4(+) lymphocyte counts <500 cells/mm(3) and among women with human papillomavirus (HPV) infection, with risk-ordering from low- to high-risk HPV type. SIL regression was less likely among HIV-seropositive women with higher HIV loads. No beneficial effect of highly active antiretroviral therapy was demonstrated.
authors.affiliation: Wayne State University School of Medicine, Detroit, Michigan 48109, USA.
authors.forename: Paula
authors.initials: P
authors.lastname: Schuman
authors.forename: Suzanne E
authors.initials: SE
authors.lastname: Ohmit
authors.forename: Robert S
authors.initials: RS
authors.lastname: Klein
authors.forename: Ann
authors.initials: A
authors.lastname: Duerr
authors.forename: Susan
authors.initials: S
authors.lastname: Cu-Uvin
authors.forename: Denise J
authors.initials: DJ
authors.lastname: Jamieson
authors.forename: Jean
authors.initials: J
authors.lastname: Anderson
authors.forename: Keerti V
authors.initials: KV
authors.lastname: Shah
mesh_terms: D000293:Adolescent; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000150:complications* / Q000453:epidemiology*; D012307:Risk Factors; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000453:epidemiology*; D014626:Vaginal Smears; D019562:Viral Load