[Lymphocytes: what is "Vav"].
Guanine exchange factors (GEF) of the Vav family are critical activators of Rho GTPases, which control actin cytoskeletal reorganization and gene transcription. Among all GEFs identified, Vav proteins are the only GEFs regulated by tyrosine phosphorylation. Moreover, their structure contains several protein-protein or protein-lipid interaction domains. These domains are involved in the formation of multimolecular signalling complexes, highlighting the adaptor role of Vav proteins. The unique combination of these properties makes Vav proteins privileged integrators of multiple signalling pathways in a broad range of tissues and cells. Lymphocyte function during inflammatory and immune responses requires a dynamic remodeling of cellular architecture. Thus, it is not surprising that Vav proteins have been found to play a central role in the regulation of physiologic and pathologic lymphocyte responses.
Charvet
Céline
C
Inserm U.343, Interactions cellulaires en immunologie et immunopathologie, Hôpital de l'Archet, Route de Saint-Antoine de Ginestière, BP 3079, 06202 Nice, France.
Deckert
Marcel
M
D020558:GTP Phosphohydrolases / Q000494:pharmacology; D006801:Humans; D007249:Inflammation; D008214:Lymphocytes / Q000502:physiology*; D015394:Molecular Structure; D015513:Oncogene Proteins / Q000494:pharmacology*; D010766:Phosphorylation; D051567:Proto-Oncogene Proteins c-vav; D015398:Signal Transduction; D014158:Transcription, Genetic; D014443:Tyrosine / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000494:pharmacology*
D015513:Oncogene Proteins; D051567:Proto-Oncogene Proteins c-vav; C496618:VAV1 protein, human; D014443:Tyrosine; D020558:GTP Phosphohydrolases; D020741:rho GTP-Binding Proteins