title: [Bactericidal effects of commonly used antiseptics/disinfectants on nosocomial bacterial pathogens and the relationship between antibacterial and biocide resistance].
abstract: Bactericidal efficacy of seven different disinfectants (chlorhexidine gluconate, povidone-iodine, glutaraldehyde, benzalkonium chloride, sodium hypochloride, ethoxydiamino acridine, the mixture of "12% ethandiol + 0.5% pentanediol + 7.5% didecyldimethylammonium cloride") commonly used at Osmangazi University, Medical Faculty Hospital, was investigated against frequent nosocomial bacterial pathogens (19 Gram-negative and 25 Gram-positive strains) by using modified Kelsey-Sykes method. Chlorhexidine gluconate, povidone-iodine and glutaraldehyde were determined as the most effective disinfectants against all of the pathogens. There was no significant difference in terms of biocide resistance between antibiotic sensitive and resistant strains. All of the P. aeruginosa strains were found to be resistant to 0.01% benzalkonium chloride and 0.25%, 0.5% and 1% concentrations of "12% ethandiol + 0.5% pentanediol + 7.5% didecyldimethyl ammonium cloride" mixture. One vancomycin resistant E. faecium strain and one extended spectrum beta-lactamase (ESBL) positive K. pneumoniae strain were found to be resistant to 0.55% sodium hypochloride. Ethoxydiamino acridine showed little or no activity against all tested strains.
authors.affiliation: Osmangazi Universitesi Tip Fakültesi, Mikrobiyoloji Anabilim Dali, Eskişehir.
authors.forename: S Elif
authors.initials: SE
authors.lastname: Fiçici
authors.forename: Gül
authors.initials: G
authors.lastname: Durmaz
authors.forename: Semra
authors.initials: S
authors.lastname: Ilhan
authors.forename: Yurdanur
authors.initials: Y
authors.lastname: Akgün
authors.forename: Nedime
authors.initials: N
authors.lastname: Köşgeroğlu
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D003428:Cross Infection / Q000382:microbiology*; D004202:Disinfectants / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000891:Anti-Infective Agents, Local; D004202:Disinfectants