title: Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses.
abstract: Antiviral properties of betulin, betulinic and betulonic acids were investigated in cell cultures infected with herpes simplex type I, influenza FPV/Rostock and ECHO 6 viruses. All studied triterpenes were active against herpes simplex virus. Betulin and especially betulinic acid also suppressed ECHO 6 virus reproduction.
authors.affiliation: Belarussian Research Institute for Epidemiology and Microbiology, 4 K Zetkin str, Minsk 220050, Belarus.
authors.forename: N I
authors.initials: NI
authors.lastname: Pavlova
authors.forename: O V
authors.initials: OV
authors.lastname: Savinova
authors.forename: S N
authors.initials: SN
authors.lastname: Nikolaeva
authors.forename: E I
authors.initials: EI
authors.lastname: Boreko
authors.forename: O B
authors.initials: OB
authors.lastname: Flekhter
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004458:Echovirus 6, Human / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009828:Oleanolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D053978:Pentacyclic Triterpenes; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014759:Viral Envelope Proteins; D000094062:Betulinic Acid
chemical_list: D000998:Antiviral Agents; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; D014315:Triterpenes; D014759:Viral Envelope Proteins; C118308:betulonic acid; D009828:Oleanolic Acid; C002503:betulin; D000094062:Betulinic Acid