Inocalophyllins A, B and their methyl esters from the seeds of Calophyllum inophyllum.
Fractionation of the ethanolic extract of the seeds of Calophyllum inophyllum L. has resulted in the isolation of four novel pyranocoumarin derivatives, designated as inocalophyllins A (1), B (2) and their methyl esters (3, 4) in addition to the known calophyllolide. The structures of these compounds have been determined on the basis of spectroscopic analysis including MS, heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC) and two dimensional incredible natural abundance double quantum transfer experiment (2D-INADEQUATE). Two new methylated products, 5 and 6 were also prepared by methylation of compounds 1 and 2, respectively.
Shen
Ya-Ching
YC
Institute of Marine Resources, National Sun Yat-sen University, Taiwan, Republic of China. ycshen@mail.nsysu.edu.tw
Hung
Meng-Chieh
MC
Wang
Li-Tang
LT
Chen
Ching-Yu
CY
D029759:Calophyllum; D004952:Esters; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D039681:Pyranocoumarins / Q000737:chemistry* / Q000302:isolation & purification*; D012639:Seeds
D004952:Esters; D010936:Plant Extracts; D039681:Pyranocoumarins