AML1 overexpression and/or mutations should be checked in trisomy 21 patients with megakaryocytic leukemia.
Huret
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Léonard
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D002891:Chromosomes, Human, Pair 21; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000175:diagnosis / Q000235:genetics*; D009154:Mutation; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics*; D014314:Trisomy
D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C493728:RUNX1 protein, human; D014157:Transcription Factors