Neuroeffector mechanisms involved in the regulation of dog splenic arterial tone.
It has been recognized that sympathetic neurons release several transmitters but mainly adenosine 5'-triphosphate (ATP), noradrenaline, and neuropeptide Y (NPY). Recently, we reported that periarterial nerve electrical stimulation (PNS) produced biphasic vasoconstrictions consisting of an initial transient, predominantly P2X-purinoceptor-mediated constriction followed by a prolonged, alpha(1)-adrenoceptor-mediated one in canine isolated splenic arteries. In this article, we tried to analyze the effects of several selective key drugs that influence the PNS-induced responses, and we functionally showed sympathetic transmitter releasing mechanisms by pharmacological analysis using purinergic, adrenergic, and NPYergic agonists and antagonists.
Chiba
Shigetoshi
S
Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan. chiba@sch.md.shinshu-u.ac.jp
Yang
Xiao-Ping
XP
D000818:Animals; D004285:Dogs; D006801:Humans; D009451:Neuroeffector Junction / Q000187:drug effects / Q000502:physiology*; D013157:Splenic Artery / Q000187:drug effects / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014666:Vasomotor System / Q000187:drug effects / Q000502:physiology*
D014662:Vasoconstrictor Agents