DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses.
Harris
Reuben S
RS
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. rsharris@mrc-lmb.cam.ac.uk
Sheehy
Ann M
AM
Craig
Heather M
HM
Malim
Michael H
MH
Neuberger
Michael S
MS
D000071480:APOBEC-3G Deaminase; D000916:Antibody Diversity; D003564:Cytidine Deaminase / Q000502:physiology; D004247:DNA / Q000378:metabolism*; D018076:DNA, Complementary / Q000096:biosynthesis; D003641:Deamination; D006801:Humans; D007113:Immunity, Innate; D009700:Nucleoside Deaminases; D011506:Proteins / Q000502:physiology*; D017393:RNA Editing; D012097:Repressor Proteins; D012192:Retroviridae Infections / Q000276:immunology*; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D018076:DNA, Complementary; D011506:Proteins; D012097:Repressor Proteins; D004247:DNA; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D009700:Nucleoside Deaminases; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase