Structural bases of recognition motif for adenine moiety.
RNA molecules with the specific three-dimensional structure, express the specific structural and catalytic functions. The polymorphic nature of helical stem packing of nucleic acids becomes an interesting phenomenon. The adenosine moiety plays a key role in helical packing and/or loop and/or bulge interactions. The database, structural information of assemblage and distribution of adenosine moiety, can be a useful tool. The geometrical parameters about hydrogen bond and base stacking would provide the tolerant aspect for multiple strand packing. The tentative database including these geometrical parameters around adenosine moiety has been constructed. The user can obtain the selected list with several descriptors for the structure definition and sequence properties. In addition to this nucleic acid system, RNA-protein system would be included. In the future, the model building program for multiple stranded helices can be performable.
Fujii
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School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka, Shizuoka 422-8526, Japan.
D000225:Adenine / Q000737:chemistry*; D030561:Databases, Nucleic Acid; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*
D012313:RNA; D000225:Adenine