Probing the mechanisms of the self ion-molecule reactions of dopamine in an ion trap mass spectrometer.
Our previous work was the first to report [M+CH](+) and [M+C(2)H(3)](+) ions in the self ion-molecule reactions (SIMR) of two aza-crown ethers in an ion trap mass spectrometer (ITMS). In this study, the CH and C(2)H(3) addition ions were also found in the SIMR of dopamine. The SIMR of dopamine lead to the formation of the protonated molecules ([M+H](+)), of adduct ions ([M+F](+), where F represents fragment ions), and of [M+CH](+), [M+C(2)H(3)](+) and [2M+H](+) ions. Based on the combination of the results of isolation experiments and semi-empirical calculations, the reactive site for the formation of the [M+H](+) and [M+CH](+) ions of dopamine is proposed to be the amino group.
Wu
Hui-Fen
HF
Department of Chemistry, Tamkang University, Tamsui, Taipei Hsien 251, Taiwan. gou@mail.tku.edu.tw
Chen
Chien-Hung
CH
Lu
Li-Chi
LC
D004298:Dopamine / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D013058:Mass Spectrometry / Q000379:methods*; D015394:Molecular Structure; D013816:Thermodynamics
D007477:Ions; D004298:Dopamine