title: Pathophysiologic characteristics of the activity-stress paradigm in animal models: inhibitory effect of glucose on these responses.
abstract: This review provides a discussion of the pathophysiologic significance of animal models of the activity-stress paradigm and the role of plasma glucose level in the appearance of physical stress responses of those models. Many research reports have demonstrated that animal models exposed to activity-stress are useful as a "symptomatic model" of anorexia nervosa and obsessive-compulsive disorder as well as peptic ulcer. Our findings show that a decrease in plasma glucose concentration is an important factor in determining the activity-stress-induced physical responses. Further investigation of the pathophysiology of activity-stressed animal models may contribute to the development of new therapeutics for diseases such as anorexia nervosa and obsessive-compulsive disorder.
authors.affiliation: Department of Pharmacology and Intractable Diseases Research Center, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeda
authors.forename: Minoru
authors.initials: M
authors.lastname: Tsuji
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hayashi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yamada
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Matsumiya
authors.forename: Miwako
authors.initials: M
authors.lastname: Koizumi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kimura
mesh_terms: D000818:Animals; D000856:Anorexia Nervosa; D001786:Blood Glucose / Q000032:analysis*; D004195:Disease Models, Animal; D005508:Food Deprivation; D005947:Glucose / Q000008:administration & dosage; D009771:Obsessive-Compulsive Disorder; D005082:Physical Exertion; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose; D005947:Glucose