Persistent indocyanine green fluorescence after vitrectomy for macular hole.
OBJECTIVE
To evaluate the persistence of indocyanine green (ICG) autofluorescence after ICG-assisted internal limiting membrane peeling for macular hole surgery.


METHODS
Interventional case series.


METHODS
Retrospective institutional study. Four eyes of four patients who underwent pars plana vitrectomy with ICG-assisted internal limiting membrane peeling for macular hole repair were imaged for ICG autofluorescence at 795 nm with a scanning laser ophthalmoscope. The main outcome measure was persistence of ICG autofluorescence.


RESULTS
All four patients demonstrated persistent ICG fluorescence in the central macula up to 8 months postsurgery.


CONCLUSIONS
Persistent ICG signal was noted in the macula months after vitrectomy for macular hole surgery. The persistence of ICG autofluorescence could be responsible for delayed photochemical damage to the retinal pigment epithelium. Further studies must quantify the risk of retinal pigment epithelium injury when ICG-assisted internal limiting membrane peeling is used in macular hole surgery.
Ciardella
Antonio P
AP
Department of Ophthalmology, Edward S. Harkness Eye Institute, New York Presbyterian Hospital, New York, New York, USA. aciardella@yahoo.com
Schiff
William
W
Barile
Gaetano
G
Vidne
Orit
O
Sparrow
Janet
J
Langton
Kevin
K
Chang
Stanley
S
D000368:Aged; D004396:Coloring Agents / Q000009:adverse effects*; D019773:Epiretinal Membrane / Q000601:surgery; D005260:Female; D005453:Fluorescence; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green / Q000009:adverse effects*; D007368:Interferometry / Q000379:methods; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced* / Q000473:pathology; D012167:Retinal Perforations / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D014054:Tomography; D014821:Vitrectomy
D004396:Coloring Agents; D007208:Indocyanine Green