Endovascular irradiation prevents smooth muscle cell proliferation and neointimal hyperplasia in rabbits.
The present study examined the temporal responses and the efficacy of 192Ir-HDR endovascular irradiation for preventing smooth muscle cell proliferation of rabbit iliac arteries after PTA with a cutting balloon catheter. Endovascular irradiation with 12 Gy was randomly performed on the one side of iliac arterial segment with the unirradiated side serving as a control. Animals were euthanatized 1, 2, 3, 4, 8 and 12 week(s) after angioplasty. Histopathological and immunohistochemical studies were carried out. Histopathology showed repair of the dissection by cellular accumulation and a striking reduction in the amount of neointimal hyperplasia in the irradiated arteries as compared with control vessels. A peak of PCNA-positive ratio was in neointima of the control arterial segments at a week. 2-4 weeks after irradiation, the neointimal PCNA-positive ratio was still significantly increased in the control arterial segments compared with the irradiated arterial segments. After 8 weeks, PCNA-positive ratio was below 1% in both irradiated arterial segments and the control. Our results showed that the 192Ir-HDR afterloading irradiation with a dose of 12 Gy can be considered sufficient for inhibiting neointimal hyperplasia in angioplastized rabbit iliac arteries with cutting balloon catheter.
Xu
L
L
Department of Radiology, Xiehe Hospital, Tongji Medical University, Wuhan 430030.
Wu
Y
Y
Feng
G
G
Oguchi
M
M
Yokota
H
H
Nakagawa
T
T
Yamamoto
I
I
D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D002455:Cell Division / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006965:Hyperplasia / Q000517:prevention & control; D007083:Iliac Artery / Q000473:pathology / Q000528:radiation effects; D007496:Iridium Radioisotopes; D009131:Muscle, Smooth, Vascular / Q000473:pathology* / Q000528:radiation effects*; D011817:Rabbits
D007496:Iridium Radioisotopes