title: The National Psoriasis Foundation Psoriasis Score (NPF-PS) system versus the Psoriasis Area Severity Index (PASI) and Physician's Global Assessment (PGA): a comparison.
abstract: The Psoriasis Area and Severity Index (PASI) and Physician Global Assessment (PGA) are commonly used, but fail to measure quality of life and the patient's perception of well-being. In response to these limitations, the National Psoriasis Foundation (NPF) Medical Advisory Board has developed the NPF Psoriasis Score (NPF-PS). This article evaluates the degree of concordance between NPF-PS, PASI, and PGA scores via an investigator-initiated, single-center, double-blind, placebo-controlled study of thirty-three patients with moderate to severe plaque psoriasis. Our results indicated that NPF-PS was strongly correlated with PASI and PGA in this study, while better reflecting patient perception. This is the first report of a double-blind placebo-controlled study demonstrating this concordance.
authors.affiliation: Clinical Research Center, UMDNJ-Robert Wood Johnson Medical School, 51 French Street, New Brunswick, NJ 08901-0019, USA. gottliab@umdnj.edu
authors.forename: Alice B
authors.initials: AB
authors.lastname: Gottlieb
authors.forename: Umesh
authors.initials: U
authors.lastname: Chaudhari
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Baker
authors.forename: Michelle
authors.initials: M
authors.lastname: Perate
authors.forename: Lisa T
authors.initials: LT
authors.lastname: Dooley
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D004311:Double-Blind Method; D005582:Foundations / Q000592:standards; D006801:Humans; D000069285:Infliximab; D008875:Middle Aged; D010820:Physicians / Q000592:standards; D011565:Psoriasis / Q000145:classification / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D014481:United States
chemical_list: D000911:Antibodies, Monoclonal; D000069285:Infliximab