title: Blood pool contrast-enhanced MRA: improved arterial visualization in the steady state.
abstract: Blood pool agents (BPAs) for contrast-enhanced magnetic resonance angiography (CE-MRA) allow prolonged imaging during the steady state when the agent is distributed through the complete vascular system. This increases both the spatial resolution and the contrast resolution. However, simultaneous venous and arterial enhancement hampers interpretation. For the pelvic region of the vasculature, it is shown that arterial visualization in this equilibrium phase can be improved if the central arterial axis (CAA) is known. However, manually obtaining this axis is not feasible in clinical practice. Therefore, a method is presented that utilizes images acquired during the first pass of the contrast agent to find the CAA in the steady-state data with minimum user initialization. The accuracy of the resulting CAA is compared with tracings of three observers in six patient datasets. It was found that the mean difference between the semiautomatic method and the manual delineation is 1.32 mm in the steady-state data, and that the resulting CAA was always within the arterial lumen, which is an important prerequisite for both improved visualization and segmentation.
authors.affiliation: Image Sciences Institute, University Medical Center, Room E.01.334, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. kees@isi.uu.nl
authors.forename: Cornelis M
authors.initials: CM
authors.lastname: van Bemmel
authors.forename: Onno
authors.initials: O
authors.lastname: Wink
authors.forename: Bert
authors.initials: B
authors.lastname: Verdonck
authors.forename: Max A
authors.initials: MA
authors.lastname: Viergever
authors.forename: Wiro J
authors.initials: WJ
authors.lastname: Niessen
mesh_terms: D000465:Algorithms; D001158:Arteries / Q000033:anatomy & histology*; D003287:Contrast Media; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D010363:Pattern Recognition, Automated; D010388:Pelvis / Q000033:anatomy & histology* / Q000098:blood supply*; D011786:Quality Control; D012815:Signal Processing, Computer-Assisted; D014680:Veins / Q000033:anatomy & histology*
chemical_list: D003287:Contrast Media