title: Anti-inflammatory activity of shikonin derivatives from Arnebia hispidissima.
abstract: Arnebia hispidissima ethanolic extract, after chromatography, yielded a number of shikonin derivatives, which were identified as arnebin-5, arnebin-6, teracryl shikonin, arnebinone and acetyl shikonin. All these compounds were firstly reported from this plant species and evaluated to the anti-inflammatory activity of ethanolic extract and isolated shikonin derivatives, models with carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats were conducted. The observed results indicated that pre-treatment with arnebinone significantly inhibited the carrageenan-induced paw edema and also suppressed the development of chronic arthritis induced by CFA.
authors.affiliation: Department of Botany, University of Rajasthan, Jaipur, India.
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: M K
authors.initials: MK
authors.lastname: Sharma
authors.forename: P R
authors.initials: PR
authors.lastname: Meghwal
authors.forename: P M
authors.initials: PM
authors.lastname: Sahu
authors.forename: S
authors.initials: S
authors.lastname: Singh
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy; D028082:Boraginaceae / Q000737:chemistry*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D000431:Ethanol; D008297:Male; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D009285:Naphthoquinones; D010936:Plant Extracts; D000431:Ethanol