title: Outbreak of carbapenem-resistant Acinetobacter baumannii producing the OXA-23 enzyme in Curitiba, Brazil.
abstract: Carbapenem-resistant Acinetobacter baumannii isolates were obtained from eight patients in two hospitals in Curitiba, Brazil. The isolates were multiresistant, belonged to a single strain, and produced the OXA-23 carbapenemase. Treatment options were limited, although the isolates were susceptible to polymyxin B in vitro. The strain contributed to the deaths of five patients.
authors.affiliation: Hospital de Clínicas da Universidade Federal do Paraná (HC), Curitiba, Brazil.
authors.forename: Libera M
authors.initials: LM
authors.lastname: Dalla-Costa
authors.forename: Juliana M
authors.initials: JM
authors.lastname: Coelho
authors.forename: Helena A P H M
authors.initials: HA
authors.lastname: Souza
authors.forename: Maria E S
authors.initials: ME
authors.lastname: Castro
authors.forename: Christiane J N
authors.initials: CJ
authors.lastname: Stier
authors.forename: Karin L
authors.initials: KL
authors.lastname: Bragagnolo
authors.forename: Alvaro
authors.initials: A
authors.lastname: Rea-Neto
authors.forename: Sergio R
authors.initials: SR
authors.lastname: Penteado-Filho
authors.forename: David M
authors.initials: DM
authors.lastname: Livermore
authors.forename: Neil
authors.initials: N
authors.lastname: Woodford
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000201:enzymology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D015780:Carbapenems / Q000494:pharmacology*; D004196:Disease Outbreaks; D024881:Drug Resistance, Bacterial; D006784:Hospitals, Teaching; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D015780:Carbapenems; C466679:beta-lactamase OXA-23; D001618:beta-Lactamases