title: Stroke-induced trismus in a pediatric patient: long-term resolution with botulinum toxin A.
abstract: We present a case of prolonged resolution of stroke-induced trismus after botulinum toxin A treatment in a 9 1/2-yr-old boy. The patient had an idiopathic right posterior fossa hemorrhage with resultant spastic quadriparesis, ataxia, dysarthria, and dysphagia. He developed right-sided trismus with only fair response to stretch. Several months after discharge, the patient had worsening trismus with an interincisal distance of only 0.4-0.7 cm and difficulty with oral hygiene and eating. The patient was treated with botulinum toxin A to the masseter muscles with minimal response. Four months later, he received botulinum toxin A to the bilateral masseter and temporalis muscles and to the right medial and lateral pterygoid muscles, with more improvement. His third and last botulinum toxin A treatment was to the bilateral masseter, temporalis, lateral, and medial pterygoid muscles in larger doses. He had an excellent response, maintaining an interincisal distance of 2.5 cm 1 yr later, with significant improvement in speaking and chewing.
authors.affiliation: Department of Pediatric Physical Medicine and Rehabilitation, Children's Hospital of the King's Daughters, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA.
authors.forename: Kathleen S
authors.initials: KS
authors.lastname: Spillane
authors.forename: Jean E
authors.initials: JE
authors.lastname: Shelton
authors.forename: Michael F
authors.initials: MF
authors.lastname: Hasty
mesh_terms: D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D008297:Male; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D020521:Stroke / Q000150:complications*; D016896:Treatment Outcome; D014313:Trismus / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A