Rhodium-catalyzed [2 + 2 + 2] cyclotrimerization in an aqueous-organic biphasic system.
Macrocyclization via rhodium-catalyzed intramolecular [2 + 2 + 2] annulation of triynes has been explored in an aqueous-organic biphasic system. The biphasic system controls the concentration of hydrophobic substrates in the aqueous reaction phase and offers diluted reaction conditions without the use of a slow addition technique. The system also achieves selective cross-annulation between hydrophobic diynes and hydrophilic alkynes.
Kinoshita
Hidenori
H
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 606-8501, Japan.
Shinokubo
Hiroshi
H
Oshima
Koichiro
K