title: Convergent evolution of gene circuits.
abstract: Convergent evolution is a potent indicator of optimal design. We show here that convergent evolution occurs in genetic networks. Specifically, we show that multiple types of transcriptional regulation circuitry in Escherichia coli and the yeast Saccharomyces cerevisiae have evolved independently and not by duplication of one or a few ancestral circuits.
authors.affiliation: Department of Biology, 167 Castetter Hall, The University of New Mexico, Albuquerque, New Mexico 87131, USA.
authors.forename: Gavin C
authors.initials: GC
authors.lastname: Conant
authors.forename: Andreas
authors.initials: A
authors.lastname: Wagner
mesh_terms: D004926:Escherichia coli / Q000235:genetics*; D019143:Evolution, Molecular; D005246:Feedback / Q000502:physiology; D020440:Gene Duplication; D005786:Gene Expression Regulation / Q000235:genetics*; D005798:Genes, Bacterial / Q000502:physiology*; D005800:Genes, Fungal / Q000502:physiology*; D016680:Genome, Bacterial; D016681:Genome, Fungal; D008957:Models, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D012568:Schizosaccharomyces / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics*