Therapeutic modalities for cow's milk allergy.
OBJECTIVE
To discuss current therapeutic modalities for cow's milk allergy and its prevention.


METHODS
The sources of data include original clinical studies carried out at Ste. Justine Hospital, as well as a systematic search of the published English and French language scientific literature restricted to human subjects using computerized searches (National Public Library of Medicine, Cochrane Database Systems Review) from 1997 to 2002. Search terms for article retrieval included food allergy, milk allergy, therapy, and prevention.


CONCLUSIONS
The therapy of food allergies depends upon an accurate diagnosis, which remains a challenge in non--IgE-mediated cases. Dietary exclusion remains the mainstay of therapy, with medications reserved for exceptional patients. Preliminary evidence suggests that pancreatic enzyme supplementation may be of benefit for cases with multiple food allergies and severe eczema. Hydrolysate formula use is currently recommended for dietary allergy prevention in infants at an increased risk when maternal milk is insufficient or unavailable. The use of partially hydrolyzed formulas to prevent allergic disorders, including atopic dermatitis, is supported by clinical studies, but cannot be used in the already sensitized, milk-allergic child. Probiotics show enormous potential in preventing food allergic disorders as well.
Seidman
Ernest G
EG
Division of Gastroenterology, Hepatology & Nutrition, Ste. Justine Hospital, Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, Canada. ernest.seidman@Umontreal.ca
Singer
Sanford
S
D000818:Animals; D000918:Antibody Specificity / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology / Q000628:therapy; D006969:Hypersensitivity, Immediate / Q000276:immunology / Q000628:therapy; D007108:Immune Tolerance / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D008892:Milk / Q000009:adverse effects* / Q000276:immunology; D016269:Milk Hypersensitivity / Q000209:etiology* / Q000276:immunology / Q000628:therapy
D007073:Immunoglobulin E