title: Effects of antipsychotics on sexual and endocrine function in women: implications for clinical practice.
abstract: Typical antipsychotic agents are commonly associated with hyperprolactinemia, which, in turn, leads to sexual dysfunction. The mechanism of action underlying this clinical phenomenon is mediated by the dopamine-blocking action of typical antipsychotic medications, which results in excessive prolactin secretion and secondary effects on gonadal function. This antipsychotic-induced sexual dysfunction is unacceptable to patients and is associated with nonadherence to medication, impacting on the overall clinical outcome and treatment success. Development of first-line atypical antipsychotic agents that do not affect prolactin production is therefore an important advance for patients requiring long-term antipsychotic therapy.
authors.affiliation: Maudsley Hospital, London, United Kingdom. s.smith@iop.kcl.ac.uk
authors.forename: Shubulade
authors.initials: S
authors.lastname: Smith
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004702:Endocrine Glands / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000139:chemically induced; D007247:Infertility, Female / Q000097:blood / Q000139:chemically induced; D011388:Prolactin / Q000097:blood; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D012725:Sexual Behavior / Q000187:drug effects* / Q000502:physiology
chemical_list: D014150:Antipsychotic Agents; D011388:Prolactin