Novel cellular approaches to repair of neurodegenerative disease: from Sertoli cells to umbilical cord blood stem cells.
Neural transplantation is a promising approach to the treatment of neurodegenerative diseases and brain injury that has been shown to be efficacious in many animal models. However, the use of fetal tissue limits the acceptability and widespread application of this technique. In this review we discuss possible alternative cell sources that may be used to repair the brain and spinal cord, with a focus on Sertoli cells, hNT Neurons, bone marrow and umbilical cord blood derived stem cells.
Sanberg
Paul R
PR
Center for Aging and Brain Repair, Department of Neurosurgery, University of South Florida College of Medicine, MDC 78, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA. psanberg@hsc.usf.edu
Willing
Alison E
AE
Cahill
David W
DW