Soluble HLA-G1 at the materno-foetal interface--a review.
HLA-G differs from the other MHC class I genes. This includes a unique promoter region, a restricted constitutive tissular distribution, the translation of different membrane-bound and soluble isoforms, a shortened cytoplasmic tail and a minimal polymorphim. Soluble HLA-G1 is an immunosuppressive molecule inducing apoptosis of activated CD8(+) T cells and down-modulating CD4(+) T cell proliferation. Soluble HLA-G1 may also contribute to the control of implantation.
Le Bouteiller
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INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, France. Philippe.Le-Bouteiller@toulouse.inserm.fr
Legrand-Abravanel
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F
Solier
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D017209:Apoptosis / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D010064:Embryo Implantation / Q000276:immunology; D004730:Endothelium, Vascular / Q000276:immunology; D005260:Female; D005805:Genes, MHC Class I; D006680:HLA Antigens / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D018448:Models, Immunological; D010920:Placenta / Q000276:immunology; D011247:Pregnancy; D011401:Promoter Regions, Genetic; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012995:Solubility
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D020033:Protein Isoforms