Hilar dissection versus the "glissonean" approach and stapling of the pedicle for major hepatectomies: a prospective, randomized trial.
OBJECTIVE
A randomized study was conducted of hilar dissection and the "glissonean" approach and stapling of the pedicle for major hepatectomies to contrast their feasibility, safety, amount of hemorrhage, postoperative complications, operative times, and costs.


BACKGROUND
The "glissonean" approach is reported as requiring a shorter portal triad closure time; furthermore, the procedure seems to expedite the transection of the liver.


METHODS
Between 1998 and 2001, 80 patients were enrolled in this study. The major liver resections included 15 extended right, 7 extended left, 42 right, and 16 left hepatectomies. The patients were randomly assigned to the hilar dissection group (G1; n = 40) or to the "glissonean" approach and stapling of the portal triad group (G2; n = 40).


RESULTS
The groups were equally matched for age, sex, diagnosis, mean resected specimen weight, number of tumoral lesions, type of liver resection performed, and percentage of patients with margin invasion (G1: 4; 10% vs G2: 5; 12.5%). The duration of the 2 procedures was similar (G1: 247 +/- 54 min vs G2: 236 +/- 43 min; P = 0.4). However, the duration of the hilar dissection was shorter for G2 (50 +/- 17 min) versus G1 (70 +/- 26 min; P <0.001). By contrast, the duration of pedicular clamping was shorter for G1 (43 +/- 15 min) versus G2 (51 +/- 15 min; P = 0.015). No differences were observed in the amount of hemorrhage (G1: 887 +/- 510 mL vs G2: 937 +/- 636 mL; P = 0.7), and only 6 patients in G1 and 10 in G2 were transfused (P = 0.26). Morbidity rates were similar for both groups (G1: 23% vs G2: 33%; P = 0.3). Surgical injury of the contralateral biliary duct was not observed. However, 3 patients in G1 and 4 patients in G2 presented a biliary fistula that resolved spontaneously. Postoperative hospital stay was similar (G1: 8 [range, 6-24] vs G2: 9 [range, 5-31] days; P = 0.6). The postoperative levels of alanine transaminase (ALT) during the 2 first postoperative days were lower for G1 than G2. Cost of the surgical material was 1235.80 US dollars for G1 and 1301.10 US dollars for G2.


CONCLUSIONS
The 2 techniques are equally effective procedures for treating hilar structures. Although en bloc stapling transection is faster, hilar dissection was associated with a shorter pedicular clamping time, less cytolysis, and the materials required were less expensive.
Figueras
Joan
J
Department of Surgery, Hospital de Bellvitge, Ciutat Sanitaria i Universitaria de Bellvitge, 08907 Barcelona, Spain. jfigueras@csub.scs.es
Lopez-Ben
Santiago
S
Lladó
Laura
L
Rafecas
Antoni
A
Torras
Jaume
J
Ramos
Emilio
E
Fabregat
Joan
J
Jaurrieta
Eduardo
E
D000328:Adult; D000368:Aged; D016063:Blood Loss, Surgical; D004210:Dissection; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000601:surgery; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D017792:Surgical Stapling; D016019:Survival Analysis; D016896:Treatment Outcome