title: A comparison of intrathecal opioid and intravenous analgesia for the incidence of cardiovascular, respiratory, and renal complications after abdominal aortic surgery.
abstract: Major surgery evokes a stress response that can produce deleterious consequences, especially in a population at high risk for those complications. We tested the hypothesis that decreasing or eliminating one of the sources of stress by providing intense analgesia in the immediate postoperative period via application of neuraxial opioids would decrease major nonsurgical complications. Two-hundred-seventeen patients scheduled to undergo abdominal aortic surgery were randomly allocated to receive either general anesthesia alone (control) or general anesthesia combined with intrathecal opioid (1 micro g/kg sufentanil with 8 micro g/kg preservative-free morphine injected at the L4-5 interspace). Postoperative care was identical in the two groups, including patient-controlled analgesia. Each patient provided an assessment of postoperative pain using a visual analog scale. Postopera-tive complications were recorded according to criteria established a priori. The administration of intrathecal opioid provided more intense analgesia than patient-controlled analgesia during the first 24 h postoperatively (P < 0.05). There was no difference between groups for the incidence of combined major cardiovascular, respiratory, and renal complications (P > 0.05) or mortality (P > 0.05). The incidence of myocardial damage or infarction, as defined by abnormal plasma concentration of troponin I, did not differ between the two groups (P > 0.05). In patients undergoing major abdominal vascular surgery, decrease of one contributor to postoperative stress, by provision of intense analgesia for the intraoperative and initial postoperative period, via application of neuraxial opioid, does not alter the combined major cardiovascular, respiratory, and renal complication rate.
  
  
  CONCLUSIONS
  Provision of intense analgesia for the initial postoperative period after major abdominal vascular surgery, via the administration of neuraxial opioid, does not alter the combined incidence of major cardiovascular, respiratory, and renal complications.
authors.affiliation: Department of Anesthesiology and Critical Care, CHU Pitié-Salpêtrière, Institut Mutualiste Montsouris, Paris, France.
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Fléron
authors.forename: Richard B
authors.initials: RB
authors.lastname: Weiskopf
authors.forename: Michèle
authors.initials: M
authors.lastname: Bertrand
authors.forename: Stéphane
authors.initials: S
authors.lastname: Mouren
authors.forename: Daniel
authors.initials: D
authors.lastname: Eyraud
authors.forename: Gilles
authors.initials: G
authors.lastname: Godet
authors.forename: Bruno
authors.initials: B
authors.lastname: Riou
authors.forename: Edouard
authors.initials: E
authors.lastname: Kieffer
authors.forename: Pierre
authors.initials: P
authors.lastname: Coriat
mesh_terms: D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D001012:Aorta, Abdominal / Q000601:surgery*; D001784:Blood Gas Analysis; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology*; D004311:Double-Blind Method; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007278:Injections, Spinal; D007674:Kidney Diseases / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009475:Neurons, Afferent / Q000187:drug effects; D010149:Postoperative Pain / Q000188:drug therapy / Q000453:epidemiology; D011182:Postoperative Care; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology; D011446:Prospective Studies; D012140:Respiratory Tract Diseases / Q000453:epidemiology* / Q000209:etiology*; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects*
chemical_list: D000701:Analgesics, Opioid