Antiischemic effects of topiramate in a transient global forebrain ischemia model: a neurochemical, histological, and behavioral evaluation.
The mechanisms of action of the anticonvulsant topiramate (TPM) are indicative of a potential benefit during cerebral ischemia. TPM was studied in a transient global forebrain ischemia (TGFI) model in gerbils in which 40 mg/kg was administered before or after TGFI. Control groups were administered 0.9% normal saline similarly. The evaluation consisted of neurochemical, histological, and functional analyses. The data obtained indicates that unlike the focal cerebral ischemia model, TPM is not neuroprotective in TGFI. The difference in effect, which may be due to the difference in species or the type of ischemia, points to the need for caution when extrapolating animal data from this drug to humans.
Khan
S H
SH
Stroke Research Unit, University of Saskatchewan, Saskatoon, SK, Canada. khan@duke.usask.ca
Wright
Sandra Lea
SL
Banigesh
Ali
A
Miyashita
Hiro
H
Todd
Kathryn
K
Hemmings
Susan Jean
SJ
Wishart
Tom
T
Shuaib
Ashfaq
A
D000818:Animals; D001522:Behavior, Animal; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005849:Gerbillinae; D008297:Male; D017551:Microdialysis; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016548:Prosencephalon / Q000473:pathology*; D000077236:Topiramate
D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose