Recent advances in the discovery of organometallic catalysts using high-throughput screening assays.
Combinatorial techniques were developed initially to accelerate the identification of molecules with biological activity. The successes of these techniques inspired the design of high-throughput methods to assist in the discovery of new catalysts. Over the past year, many groups in academia and industry have utilized high-throughput screening assays to reduce the time required to identify catalysts for asymmetric processes, cross-coupling reactions and other metal-catalyzed transformations. The continued success of combinatorial techniques in organometallic chemistry should propagate the development of new and improved methods to facilitate catalyst discovery.
Stambuli
James P
JP
Department of Chemistry, Yale University, PO Box 208107, New Haven, Connecticut 06520-8107, USA.
Hartwig
John F
JF
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D009942:Organometallic Compounds / Q000737:chemistry*
D009942:Organometallic Compounds