title: Optimization of a simple method for the chiral separation of methamphetamine and related compounds in clandestine tablets and urine samples by beta-cyclodextrine modified capillary electrophoresis: a complementary method to GC-MS.
abstract: The chiral separation of (+/-)-methamphetamine, (+/-)-methcathinone, (+/-)-ephedrine and (+/-)-pseudoephedrine by means of beta-cyclodextrine modified capillary electrophoresis is described. The distribution of enantiomers in clandestine tablets and urine samples were identified. Several electrophoretic parameters such as the concentration of beta-cyclodextrin, temperature, the applied voltage and the amount of organic solvent required for successful separation were optimized. The method, as described herein, represents a good complementary method to GC-MS for use in forensic and clinical analysis.
authors.affiliation: Department of Chemistry, National Taiwan Normal University, 88 Sec. 4, Tingchow Road, Taipei, Taiwan.
authors.forename: An-Shu
authors.initials: AS
authors.lastname: Liau
authors.forename: Ju-Tsung
authors.initials: JT
authors.lastname: Liu
authors.forename: Li-Chan
authors.initials: LC
authors.lastname: Lin
authors.forename: Yu-Chih
authors.initials: YC
authors.lastname: Chiu
authors.forename: You-Ren
authors.initials: YR
authors.lastname: Shu
authors.forename: Chung-Chen
authors.initials: CC
authors.lastname: Tsai
authors.forename: Cheng-Huang
authors.initials: CH
authors.lastname: Lin
mesh_terms: D000697:Central Nervous System Stimulants / Q000737:chemistry / Q000302:isolation & purification / Q000652:urine; D003505:Cyclodextrins; D019075:Electrophoresis, Capillary / Q000379:methods*; D004809:Ephedrine / Q000737:chemistry / Q000302:isolation & purification / Q000652:urine; D005554:Forensic Medicine / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013287:Illicit Drugs / Q000737:chemistry*; D008694:Methamphetamine / Q000737:chemistry / Q000302:isolation & purification / Q000652:urine; D015394:Molecular Structure; D011427:Propiophenones / Q000737:chemistry / Q000302:isolation & purification / Q000652:urine; D013237:Stereoisomerism; D013607:Tablets
chemical_list: D000697:Central Nervous System Stimulants; D003505:Cyclodextrins; D013287:Illicit Drugs; D011427:Propiophenones; D013607:Tablets; C047806:monomethylpropion; D008694:Methamphetamine; D004809:Ephedrine