title: Activity of telithromycin against penicillin-resistant Streptococcus pneumoniae isolates recovered from French children with invasive and noninvasive infections.
abstract: We compared the activities of telithromycin, erythromycin, azithromycin, josamycin, penicillin G, amoxicillin, cefpodoxime, and ceftriaxone against invasive and noninvasive non-penicillin-susceptible Streptococcus pneumoniae isolates recovered from children. Of the 186 isolates tested, 89% were positive for erm(B) by PCR. Telithromycin had the lowest MICs, with MICs at which 90% of the isolates tested are inhibited of 0.032 and 0.25 micro g/ml for erythromycin-sensitive and -resistant isolates, respectively.
authors.affiliation: Service de Microbiologie, Hôpital Robert Debré, Paris, France. edouard.bingen@rdb.ap-hop-paris.fr
authors.forename: Edouard
authors.initials: E
authors.lastname: Bingen
authors.forename: Catherine
authors.initials: C
authors.lastname: Doit
authors.forename: Chawki
authors.initials: C
authors.lastname: Loukil
authors.forename: Naima
authors.initials: N
authors.lastname: Brahimi
authors.forename: Philippe
authors.initials: P
authors.lastname: Bidet
authors.forename: Dominique
authors.initials: D
authors.lastname: Deforche
authors.forename: Pierre
authors.initials: P
authors.lastname: Geslin
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology; D002648:Child; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D005602:France; D006801:Humans; D066298:In Vitro Techniques; D015570:Josamycin / Q000494:pharmacology; D048628:Ketolides; D018942:Macrolides; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D011008:Pneumococcal Infections / Q000188:drug therapy*; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D000097623:Cefpodoxime
chemical_list: D000658:Amoxicillin; D000900:Anti-Bacterial Agents; D017963:Azithromycin; D015296:Ceftizoxime; D002443:Ceftriaxone; D004917:Erythromycin; D015570:Josamycin; D048628:Ketolides; D018942:Macrolides; D010400:Penicillin G; D010406:Penicillins; D000097623:Cefpodoxime; C106791:telithromycin