title: Mitomycin-C in the postsurgical ear canal.
abstract: OBJECTIVE
  Our goal was to evaluate the use of topical mitomycin-C (MMC) in the prevention of scar tissue formation in the postsurgical external auditory canal (EAC). Study design and setting We conducted a prospective pilot study at a tertiary care institution.
  
  
  METHODS
  Six patients with recurrent postoperative granulation tissue after canaloplasty, tympanomastoidectomy, or lateral temporal bone resection were included. MMC (0.5 mg/mL) was applied topically for 5 minutes to the EAC/mastoid cavity.
  
  
  RESULTS
  Outcomes were measured at initial MMC application and 1 and 3 months thereafter using a visual analog scale score based on the degree of EAC occlusion by granulation tissue. Need for debridement of recurrent granulation tissue on follow-up was noted. Three (50%) patients had improved VAS 1 month after treatment. Two (33%) had improved visual analog scale score at 3 months. Five (83%) required at least one debridement procedure. Repeat MMC application was performed in 2 patients.
  
  
  CONCLUSIONS
  Topical MMC was ineffective in preventing scar formation in the postsurgical EAC.
authors.affiliation: Department of Otorhinolaryngology, Weill College of Medicine of Cornell University, New York, New York, 10021, USA.
authors.forename: Vishal
authors.initials: V
authors.lastname: Banthia
authors.forename: Samuel H
authors.initials: SH
authors.lastname: Selesnick
mesh_terms: D000328:Adult; D000368:Aged; D002921:Cicatrix / Q000517:prevention & control*; D003646:Debridement / Q000379:methods; D004424:Ear Canal / Q000473:pathology / Q000601:surgery; D004432:Ear, Middle / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006097:Granulation Tissue / Q000187:drug effects; D006801:Humans; D008297:Male; D008416:Mastoid; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D010865:Pilot Projects; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D013701:Temporal Bone
chemical_list: D016685:Mitomycin