[When the mother further impacts the destiny of her offspring: maternal effect mutations].
Genes affected by maternal effect mutations encode maternal factors (transcripts, proteins) which are normally stored in oocytes and used by the embryos after fertilization. Although females bearing this type of mutation are viable and appear to be normal, embryonic development and survival of their offspring are compromised. Although maternal effect mutations are well known in lower organisms, such as drosophila or zebrafish, several examples have been only quite recently reported in mammals (Dnmt, Hsf1 and Mater). These studies provide new insights on the aspects of embryonic development directly controlled by maternal factors brought by the oocytes.
Christians
Elisabeth S
ES
Department of Internal Medicine, Molecular Cardiology Research Laboratories, the University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390-8573, USA. Elisabeth.Christians@utsouthwestern.edu
D000818:Animals; D004625:Embryo, Nonmammalian / Q000502:physiology; D005314:Embryonic and Fetal Development / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009154:Mutation; D009865:Oocytes / Q000502:physiology*