title: Effect of denuded endothelial cells on arginine amidase activity released from rabbit arteries.
abstract: 1. We examined the secretion of arginine amidase activity from rabbit aorta and ear arteries. 2. The amount of arginine amidase activity spontaneously secretion from the aorta was significantly less than that secreted from the ear artery. Dermatan sulphate significantly facilitated the secretion of arginine amidase activity from both the aorta and ear artery. 3. The dermatan sulphate-enhanced secretion of arginine amidase activity from the aorta and ear artery was reduced by denudation of the endothelium. 4. These findings may indicate that spontaneous release of arginine amidase activity from vascular smooth muscle and the enhancement of secretion of arginine amidase activity produced by dermatan sulphate depends on the endothelium.
authors.affiliation: Department of Clinical Pharmacology, Meiji Pharmaceutical University and Seikagaku Kogyo Co., Tokyo, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Naito
authors.forename: Reiko
authors.initials: R
authors.lastname: Ishii-Nozawa
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Shimokawa
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Koichi
authors.initials: K
authors.lastname: Takeuchi
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000201:enzymology / Q000378:metabolism*; D001158:Arteries / Q000201:enzymology / Q000378:metabolism*; D042783:Endothelial Cells / Q000201:enzymology / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000201:enzymology / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D011817:Rabbits; D012697:Serine Endopeptidases / Q000378:metabolism*
chemical_list: D012697:Serine Endopeptidases; C402942:arginine amidase