title: [Relation of age and prostatic volume to cancer detection in prostatic biopsies from patients with non-suspect rectal palpation].
abstract: OBJECTIVE
  To evaluate which clinical variables are predictive for prostate cancer and possible relationships among them, in patients with elevated PSA and non suspicious digital rectal examination (DRE) undergoing first prostate biopsy.
  
  
  METHODS
  1618 patients with elevated PSA and non suspicious DRE who underwent sextant peripheral prostate biopsy were selected from our database. PSA, age, prostate volume, and detectable nodule by ultrasound were selected as variables related to cancer detection in first and second biopsies.
  
  
  RESULTS
  Mean age was 67.5 +/- 7.4 (37-88) years, mean PSA was 16.9 +/- 116.5 (3.6-4500) ng\ml, mean prostate volume was 65.7 +/- 37.8 (8-352) cc. 23.3% patients presented a hypoechoic nodule within the peripheral zone of the gland. 18.8% presented prostate cancer on first biopsy. On multivariate analysis, age (p < 0.001), prostate volume (p < 0.001), and presence of a nodule on ultrasound (p = 0.003) were considered independent predictive variables for cancer detection on biopsy. Direct relationship with age, and inverse relationship with prostate volume were shown. Detection rates on second biopsy were greater in patients with prostates = 40 cc in comparison to those > 40 cc (p = 0.02). First two biopsies detected 95% of cancer cases, first three up to 98%.
  
  
  CONCLUSIONS
  Age and prostate volume should be taken into consideration when individualizing the number of cores to obtain at the time of biopsy. The efficacy of peripheral sextant biopsy in prostates = for 40 cc should be re-evaluated. Third and fourth biopsies should be reserved for patients with very adverse risk factors.
authors.affiliation: Servicio de Urología, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: Felipe
authors.initials: F
authors.lastname: Herranz Amo
authors.forename: Fernando
authors.initials: F
authors.lastname: Verdú Tartajo
authors.forename: José María
authors.initials: JM
authors.lastname: Díez Cordero
authors.forename: David
authors.initials: D
authors.lastname: Subira Ríos
authors.forename: Irene
authors.initials: I
authors.lastname: Castaño González
authors.forename: Mercedes
authors.initials: M
authors.lastname: Moralejo Gárate
authors.forename: Juan Ignacio
authors.initials: JI
authors.lastname: Martínez Salamanca
authors.forename: Ramiro
authors.initials: R
authors.lastname: Cabello Benavente
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D001707:Biopsy, Needle; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D010173:Palpation; D011237:Predictive Value of Tests; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors; D014463:Ultrasonography
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen