title: Nasal septal perforations during treatment with topical nasal glucocorticosteroids are generally not associated with contact allergy to steroids.
abstract: BACKGROUND
  Mucosal ulcers and perforations of the nasal septum are very rare and may have several underlying causes. Contact allergy to steroids has been suggested as a possible aetiological factor in patients who develop perforations during topical steroid use.
  
  
  METHODS
  We have identified 13 subjects with perforations of their nasal septum and concomitant topical nasal steroid use. In order to evaluate whether these patients had developed contact allergy to steroids they underwent patch testing with an extended steroid series.
  
  
  RESULTS
  None of the subjects displayed any positive reaction to the steroids.
  
  
  CONCLUSIONS
  Sensitivity to glucocorticoids is a well-described phenomenon and may in selected subjects also be associated with local side effects to nasal sprays. However, contact allergy to steroids does not seem to be a general explanation for septal perforations in patients using nasal steroids.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, Lund, Sweden. anders.cervin@onh.lu.se
authors.forename: Anders
authors.initials: A
authors.lastname: Cervin
authors.forename: Christer
authors.initials: C
authors.lastname: Hansson
authors.forename: Lennart
authors.initials: L
authors.lastname: Greiff
authors.forename: Morgan
authors.initials: M
authors.lastname: Andersson
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005938:Glucocorticoids; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects; D009300:Nasal Septum / Q000187:drug effects; D009668:Nose Diseases / Q000150:complications / Q000188:drug therapy*; D010328:Patch Tests / Q000379:methods; D014456:Ulcer / Q000209:etiology
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids