c-erbB-4/HER4: friend or foe?
The c-erbB-4 receptor has ligand stimulated tyrosine kinase activity but reports differ as to whether it induces cell division or differentiation. There is also controversy regarding its role in breast cancer, with some reports associating overexpression with short survival and others with longer life.
Gullick
William J
WJ
Cancer Biology Laboratory, Research School of Biosciences, University of Kent at Canterbury, Canterbury, UK. W.J.Gullick@ukc.ac.uk
D001943:Breast Neoplasms / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D011379:Prognosis; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D066247:Receptor, ErbB-4; D015398:Signal Transduction / Q000235:genetics
C587689:ERBB4 protein, human; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases; D066247:Receptor, ErbB-4