Electrospray ionization mass spectrometry of AZT H-phosphonates conjugated with steroids.
AZT H-phosphonates conjugated with steroids were synthesized and determined by positive and negative ion electrospray ionization mass spectrometry (ESI-MS) in conjunction with tandem mass spectrometry (MS/MS). The fragmentation pathways were investigated in detail. There are very different characteristic fragment ions in the positive and negative ion MS/MS spectra. The azide group of compounds 6a and 6b underwent either elimination of HN(3) or rearrangement to an amine in both positive and negative ion mass spectrometry.
Xiao
Qiang
Q
The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China.
Ju
Yong
Y
Yang
Xinping
X
Zhao
Yu-Fen
YF
D002784:Cholesterol / Q000032:analysis / Q000737:chemistry; D004144:Diosgenin / Q000032:analysis / Q000737:chemistry; D004347:Drug Interactions; D015394:Molecular Structure; D063065:Organophosphonates / Q000032:analysis* / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013256:Steroids / Q000032:analysis* / Q000737:chemistry*; D015215:Zidovudine / Q000032:analysis* / Q000737:chemistry*
D063065:Organophosphonates; D013256:Steroids; D015215:Zidovudine; D002784:Cholesterol; D004144:Diosgenin