title: Primary malignant melanoma of the cervix uteri: a case report of a rare tumor.
abstract: We present a case of malignant melanoma of the uterine cervix by focussing on the pathological and immunohistochemical studies that were done to confirm the diagnosis. A 67-year-old postmenopausal women suffering from vaginal bleeding was diagnosed with a polypous tumor at the uterine cervix. The histological diagnosis of a biopsy was pleomorphic malignant melanoma. Colpohysterectomy with bilateral adnexectomy, inguinal and pelvic lymphonodectomy was performed. The tumor was examined by histological and immunohistochemical methods. Multiple atypical cells (PAP V) were found in the cytological examination. The histological preparation showed partly atypical parvicellular, partly solid clear cellular tissue. The immunohistochemical staining reaction with pancytokeratin, LCA, estrogen- and progesterone- receptor was negative. A positive reaction was found on vimentin, S-100 and HMB-45. Thirty percent of the nuclei showed a positive reaction on the proliferation marker MIB1. The tumor was finally diagnosed as a primary pleomorphic malignant melanoma of the portio-vaginal border with satellite metastases into the vaginal wall and tumor thickness 2 mm. The value of immunohistochemical examination enabled us to make the diagnosis of a malignant melanoma of an unusual localisation at the cervix.
authors.affiliation: University of Rostock, Department of Obstetrics and Gynecology, Doberaner Str. 142, 18057 Rostock, Germany. josef.makovitzky@med.uni-rostock.de
authors.forename: J
authors.initials: J
authors.lastname: Makovitzky
authors.forename: C
authors.initials: C
authors.lastname: Schmitz
authors.forename: B
authors.initials: B
authors.lastname: Vogt-Weber
authors.forename: H
authors.initials: H
authors.lastname: Nizze
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D009361:Neoplasm Invasiveness; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery