title: Isolation and structures of avicins D and G: in vitro tumor-inhibitory saponins derived from Acacia victoriae.
abstract: Two new saponins named avicins D (1) and G (2) were isolated from the seed pods of the desert legume plant Acacia victoriae. The structures, elucidated by 1D and 2D NMR studies and by chemical means, were characterized as acacic acid-bearing oligosaccharides at C-3 and C-28 with a side chain linked to C-21 comprised of two monoterpene carboxylic acids and a quinovose moiety. Both compounds exhibited potent cytotoxicity (apoptosis) against human T-cell leukemia (Jurkat cells) in vitro.
authors.affiliation: Hauser, Inc., 6880 N. Broadway, Suite H, Denver, CO 80221, USA. gaminij@hauser.com
authors.forename: Gamini S
authors.initials: GS
authors.lastname: Jayatilake
authors.forename: Delano R
authors.initials: DR
authors.lastname: Freeberg
authors.forename: Zhengjie
authors.initials: Z
authors.lastname: Liu
authors.forename: Steve L
authors.initials: SL
authors.lastname: Richheimer
authors.forename: Mary E
authors.initials: ME
authors.lastname: Blake Nieto
authors.forename: David T
authors.initials: DT
authors.lastname: Bailey
authors.forename: Valsala
authors.initials: V
authors.lastname: Haridas
authors.forename: Jordan U
authors.initials: JU
authors.lastname: Gutterman
mesh_terms: D000045:Acacia / Q000737:chemistry*; D001130:Arizona; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D019169:Jurkat Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009844:Oligosaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D009844:Oligosaccharides; D012503:Saponins; D013729:Terpenes; C478446:avicin G; C478445:avicin D