Genetic profile of clear cell odontogenic carcinoma.
In the head and neck region, clear cell tumors are usually derived from salivary glands, odontogenic tissues, and metastasis. The World Health Organization has classified clear cell odontogenic tumor among benign tumors, but it is now recognized as a more sinister lesion, and current opinion is that it should be designated as a carcinoma. It is characterized by aggressive growth, recurrences, and metastasis. By using complementary DNA microarrays, several genes in clear cell odontogenic tumor were identified that are differentially regulated when compared with non-tumor tissue. In conclusion, the first genetic profiling of clear odontogenic carcinoma is reported. DNA microarrays can potentially help in identifying some genes whose products could be disease-specific targets for cancer therapy as well as a tool for better classifying odontogenic tumor.
Carinci
Francesco
F
Departments of Maxillofacial Surgery, University of Ferrara, Arcispedale S. Anna, Corso Giovecca 203, 44100 Ferrara, Italy. crc@unife.it
Volinia
Stefano
S
Rubini
Corrado
C
Fioroni
Massimiliano
M
Francioso
Francesca
F
Arcelli
Diego
D
Pezzetti
Furio
F
Piattelli
Adriano
A
D018262:Adenocarcinoma, Clear Cell / Q000235:genetics* / Q000473:pathology; D015536:Down-Regulation / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008441:Maxillary Neoplasms / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009808:Odontogenic Tumors / Q000235:genetics* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis; D015854:Up-Regulation / Q000235:genetics