[Two cases of mineralocorticoids deficiency as first endocrine manifestation of APECED syndrome].
The Authors report two cases of APECED syndrome (Auto-immune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy) revealed by hyponatremia due to isolated mineralocorticoids deficiency. Such cases illustrate the variable endocrine features revealing the syndrome. The mechanisms underlying the auto-immune destruction of the adrenals are discussed.
Barat
P
P
Service d'endocrinologie pédiatrique, hôpital des enfants, centre hospitalier universitaire Bordeaux, place Amélie-Raba-Léon, 33076, Bordeaux cedex, France. baratp@club-internet.fr
Joussein
M
M
Carel
J C
JC
D000311:Adrenal Glands / Q000473:pathology / Q000502:physiology; D002675:Child, Preschool; D006801:Humans; D007010:Hyponatremia / Q000209:etiology* / Q000473:pathology; D008297:Male; D008901:Mineralocorticoids / Q000172:deficiency*; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications* / Q000175:diagnosis*
D008901:Mineralocorticoids