Adult cardiac stem cells--where do we go from here?
A potential treatment for cardiovascular disease involves the transplantation of a patient's bone marrow stem cells into the heart of that same patient. In order to maximize the potential benefits to select patient populations, the continued clinical development of this technology will require a comprehensive understanding of the role(s) of the transplanted cells in the repair of damaged heart tissue as well as an understanding of which types of cardiac injury can be repaired by this approach. The widespread application of cardiovascular stem cell therapies, however, will likely be based on pharmacological approaches to enhance the capacity of endogenous bone marrow stem cells to provide for the replacement of cardiac muscle and vascular cells after myocardial injury.
Edelberg
Jay M
JM
Department of Medicine, Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA. jme2002@med.cornell.edu
Xaymardan
Munira
M
Rafii
Shahin
S
Hong
Mun K
MK
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000628:therapy*; D002454:Cell Differentiation; D002986:Clinical Trials as Topic; D006801:Humans; D009206:Myocardium / Q000166:cytology*; D032383:Myocytes, Cardiac / Q000166:cytology*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects
D002317:Cardiovascular Agents