title: Conserved microtubule-actin interactions in cell movement and morphogenesis.
abstract: Interactions between microtubules and actin are a basic phenomenon that underlies many fundamental processes in which dynamic cellular asymmetries need to be established and maintained. These are processes as diverse as cell motility, neuronal pathfinding, cellular wound healing, cell division and cortical flow. Microtubules and actin exhibit two mechanistic classes of interactions--regulatory and structural. These interactions comprise at least three conserved 'mechanochemical activity modules' that perform similar roles in these diverse cell functions.
authors.affiliation: Department of Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
authors.forename: Olga C
authors.initials: OC
authors.lastname: Rodriguez
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Schaefer
authors.forename: Craig A
authors.initials: CA
authors.lastname: Mandato
authors.forename: Paul
authors.initials: P
authors.lastname: Forscher
authors.forename: William M
authors.initials: WM
authors.lastname: Bement
authors.forename: Clare M
authors.initials: CM
authors.lastname: Waterman-Storer
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D003285:Contractile Proteins / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000648:ultrastructure; D020439:Growth Cones / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology
chemical_list: D003285:Contractile Proteins