title: A four component coupling strategy for the synthesis of D-phenylglycinamide-derived non-covalent factor Xa inhibitors.
abstract: A novel isonitrile derivative was synthesized and used in an Ugi four component coupling reaction to explore aryl group substitution effects on inhibition of the coagulation cascade serine protease factor Xa.
authors.affiliation: Lilly Research Laboratories, A Division of Eli Lilly and Company, IN 46285, Indianapolis, USA. sheehan_scott@lilly.com
authors.forename: Scott M
authors.initials: SM
authors.lastname: Sheehan
authors.forename: John J
authors.initials: JJ
authors.lastname: Masters
authors.forename: Michael R
authors.initials: MR
authors.lastname: Wiley
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Young
authors.forename: John W
authors.initials: JW
authors.lastname: Liebeschuetz
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Jones
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Murray
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Franciskovich
authors.forename: David B
authors.initials: DB
authors.lastname: Engel
authors.forename: Wayne W
authors.initials: WW
authors.lastname: Weber
authors.forename: Jothirajah
authors.initials: J
authors.lastname: Marimuthu
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Kyle
authors.forename: Jeffrey K
authors.initials: JK
authors.lastname: Smallwood
authors.forename: Mark W
authors.initials: MW
authors.lastname: Farmen
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Smith
mesh_terms: D065427:Factor Xa Inhibitors; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D065427:Factor Xa Inhibitors; D007202:Indicators and Reagents; D015842:Serine Proteinase Inhibitors; C470025:phenylglycinamide; D005998:Glycine