title: Oral iodine toxicity in chicks can be reversed by supplemental bromine.
abstract: Four chick bioassays were conducted to quantify iodine (I) toxicity and its amelioration in young chicks. A supplemental I level from KI of 600 mg/kg depressed growth in chicks fed methionine-deficient diets but not in those fed methionine-adequate diets. An I dose level >or= 900 mg/kg was required to cause growth depression in chicks fed a methionine-adequate corn-soybean meal diet. Iodine intoxicated chicks also displayed neurological symptoms and extreme malaise, but dose levels up to 1200 mg I/kg had no effect on blood hemoglobin or hematocrit. Supplemental I levels of 1000-1500 mg/kg caused severe growth depressions that could be totally reversed by dietary addition of 50 or 100 mg/kg bromine provided as NaBr. Nuclear accidents or terrorist actions that result in I toxicity and thyroid cancer or goiter may benefit from use of NaBr as a therapeutic agent.
authors.affiliation: Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA. dhbaker@uiuc.edu
authors.forename: David H
authors.initials: DH
authors.lastname: Baker
authors.forename: Theresa M
authors.initials: TM
authors.lastname: Parr
authors.forename: Nathan R
authors.initials: NR
authors.lastname: Augspurger
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000931:Antidotes / Q000008:administration & dosage* / Q000627:therapeutic use; D001965:Bromides / Q000008:administration & dosage* / Q000627:therapeutic use; D002645:Chickens; D007455:Iodine / Q000506:poisoning*; D011041:Poisoning / Q000188:drug therapy; D017670:Sodium Compounds / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000931:Antidotes; D001965:Bromides; D017670:Sodium Compounds; D007455:Iodine; C027938:sodium bromide