title: Pyranose oxidase identified as a member of the GMC oxidoreductase family.
abstract: Fungal pyranose oxidase is a flavoenzyme whose preferred substrate among several monosaccharides is D-glucose. After a comprehensive analysis of conserved features in a structure-based multiple sequence alignment of homologous proteins, we could classify this enzyme into the GMC oxidoreductase family. The identified homology also suggests a three-dimensional protein structure similar to the functionally related glucose oxidase.
authors.affiliation: Max-Planck-Institute for Informatics, Stuhlsatzenhausweg 85, 66123 Saarbrücken, Germany. mario.albrecht@mpi-sb.mpg.de
authors.forename: Mario
authors.initials: M
authors.lastname: Albrecht
authors.forename: Thomas
authors.initials: T
authors.lastname: Lengauer
mesh_terms: D000595:Amino Acid Sequence; D001487:Basidiomycota / Q000737:chemistry* / Q000145:classification; D002237:Carbohydrate Dehydrogenases / Q000737:chemistry* / Q000145:classification*; D017124:Conserved Sequence; D030562:Databases, Protein; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism; D005948:Glucose Dehydrogenases / Q000737:chemistry* / Q000145:classification*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010088:Oxidoreductases / Q000737:chemistry / Q000145:classification; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
chemical_list: D005656:Fungal Proteins; D010088:Oxidoreductases; D002237:Carbohydrate Dehydrogenases; D005948:Glucose Dehydrogenases; C022489:pyranose oxidase