title: Brenner, the worm and the prize.
abstract: The recent award of a Nobel Prize to Sydney Brenner crowns an astonishingly distinguished scientific career. He must have come very close to winning it several times in the past. A colleague described him as 'a visionary who sees further into the future than anyone'. This is borne out by his decision--made 40 years ago--to study a one-millimetre long worm in detail to define the biochemical and genetic control of its development and differentiation. The impact of these studies has been so profound, with a significant bearing on human physiology and disease, that over 400 laboratories worldwide have now adopted the worm as a research tool. In this article, a brief outline is given of his work on the worm and of some of the highlights of his brilliant career.
authors.affiliation: Royal College of Physicians.
authors.forename: Raymond
authors.initials: R
authors.lastname: Hoffenberg
mesh_terms: D000818:Animals; D001315:Australia; D017173:Caenorhabditis elegans / Q000235:genetics*; D015509:Developmental Biology / Q000266:history; D049673:History, 20th Century; D006801:Humans; D009613:Nobel Prize; D012333:RNA, Messenger / Q000266:history* / Q000302:isolation & purification
chemical_list: D012333:RNA, Messenger