title: Paralytic poliomyelitis caused by a vaccine-derived polio virus in an antibody-deficient Argentinean child.
abstract: We describe a case of poliomyelitis in a 3-year-old Argentinean boy with X-linked hypogammaglobulinemia. The child had no history of polio vaccination, but a poliovirus isolated from a stool sample had 97.2% genetic similarity to the Sabin 1 vaccine strain. According to the WHO definition, this is the first case reported of a vaccine-derived poliovirus infection recorded in continental Latin America.
authors.affiliation: National Polio Eradication Program, Neurology Service, Ricardo Gutiérrez Hospital for Children, Buenos Aires, Argentina. hidalgosolange@hotmail.com
authors.forename: Solange
authors.initials: S
authors.lastname: Hidalgo
authors.forename: Marcela
authors.initials: M
authors.lastname: García Erro
authors.forename: Daniel
authors.initials: D
authors.lastname: Cisterna
authors.forename: M Cecilia
authors.initials: MC
authors.lastname: Freire
mesh_terms: D000361:Agammaglobulinemia / Q000276:immunology*; D002675:Child, Preschool; D005243:Feces / Q000821:virology; D005500:Follow-Up Studies; D006801:Humans; D016867:Immunocompromised Host; D007843:Latin America; D008297:Male; D010243:Paralysis / Q000175:diagnosis / Q000209:etiology; D011051:Poliomyelitis / Q000175:diagnosis / Q000209:etiology*; D017955:Poliovirus / Q000302:isolation & purification*; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage / Q000009:adverse effects*; D018570:Risk Assessment; D014611:Vaccination / Q000009:adverse effects
chemical_list: D011055:Poliovirus Vaccine, Oral