title: [Systemic and local allergy to human insulin].
abstract: After introduction of recombinant human insulin, immunological reactions have become rare, but symptomatic immune reactions to insulin still occur. We present four insulin-treated diabetic patients who developed hypersensitivity to insulin or additives to insulin preparations. We show that symptomatic immunological reactions to insulin have not been eliminated by the introduction of recombinant human insulin. Furthermore it demonstrates the importance of skin-biopsy-verified diagnoses and the relevance of differentiation between different types of insulin allergy.
authors.affiliation: Steno Diabetes Center, Gentofte.
authors.forename: Minna
authors.initials: M
authors.lastname: Wittrup
authors.forename: Julie
authors.initials: J
authors.lastname: Pildal
authors.forename: Ase Krogh
authors.initials: AK
authors.lastname: Rasmussen
authors.forename: Birgit Guldhammer
authors.initials: BG
authors.lastname: Skov
authors.forename: Jørgen
authors.initials: J
authors.lastname: Petersen
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Mandrup-Poulsen
mesh_terms: D000328:Adult; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D006969:Hypersensitivity, Immediate / Q000139:chemically induced; D007004:Hypoglycemic Agents / Q000009:adverse effects* / Q000276:immunology; D007105:Immune Complex Diseases / Q000139:chemically induced; D007328:Insulin / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D014581:Urticaria / Q000139:chemically induced / Q000473:pathology; D014657:Vasculitis / Q000139:chemically induced
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin