title: Field trial on the efficacy of an experimental fasciolicide compared with some commercial compounds in naturally infected cattle.
abstract: The efficacy of 5-chloro-2-methylthio-6-(1-napthyloxy)-1H-benzimidazole was evaluated with three commercial fasciolicides in terms of the percentage of egg reduction in cattle. Fifty Swiss cows were selected for inclusion in the trial based on finding eggs of Fasciola hepatica in their feces. On day 0, they were blocked in five groups (G) of ten animals each according to fecal egg counts. G1 received compound alpha at 12 mg/kg p.o.; G2 triclabendazole at 12 mg/kg p.o.; G3.closantel at 3.5 mg/kg s.c.; G4 clorsulon at 2.0 mg/kg s.c. G5 animals served as untreated controls. Fecal analysis was performed on days 0, 7, 14, 21, 28, 60 and 90. Efficacy was measured on days 14 and 21. In addition, the extension and intensity effects were determined on day 60. The percentage efficacy for groups 1-4 was 98.1, 98.7, 98.2 and 97.9 on day 14 and 98.5, 97.9, 97.7 and 97.9 on day 21, respectively. No statistical differences were observed between treated groups.
authors.affiliation: Departamento de Parasitología, Facultad de Medicina Veterinaria y Zootecnia, UNAM, CP 04510, Mexico City, Mexico.
authors.forename: Y
authors.initials: Y
authors.lastname: Vera Montenegro
authors.forename: F
authors.initials: F
authors.lastname: Ibarra Velarde
authors.forename: H
authors.initials: H
authors.lastname: Quiroz Romero
authors.forename: A
authors.initials: A
authors.lastname: Hernández Campos
authors.forename: R
authors.initials: R
authors.lastname: Castillo
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005210:Fasciola hepatica; D005211:Fascioliasis / Q000188:drug therapy / Q000662:veterinary*; D005243:Feces / Q000469:parasitology; D010270:Parasite Egg Count; D012458:Salicylanilides / Q000627:therapeutic use; D013424:Sulfanilamides / Q000627:therapeutic use; D016896:Treatment Outcome; D000077682:Triclabendazole
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D012458:Salicylanilides; D013424:Sulfanilamides; D000077682:Triclabendazole; C015675:clorsulon; C023342:closantel