Epibatidine: impact on nicotinic receptor research.
Epibatidine is a natural product that was isolated and identified by Daly and coworkers in 1992. Since that time, it has had a profound influence on the investigation of alpha4beta2 nicotinic cholinergic (nACh) receptor pharmacophore models, and has inspired the development of novel agents with therapeutic potential in CNS disorders. Apart from acetylcholine and nicotine, probably no other agent has had as much recent impact on nACh research as has epibatidine.
Dukat
Małgorzata
M
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298, USA.
Glennon
Richard A
RA
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D002490:Central Nervous System / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009538:Nicotine / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry; D011978:Receptors, Nicotinic / Q000187:drug effects* / Q000378:metabolism
D019086:Bridged Bicyclo Compounds, Heterocyclic; D011725:Pyridines; D011978:Receptors, Nicotinic; D009538:Nicotine; C082748:epibatidine; D000109:Acetylcholine