Association of vitamin D receptor gene polymorphisms with bone mineral density in postmenopausal women of Hellenic origin.
OBJECTIVE
There are numerous indications that genetic factors play an important role in the pathogenesis of osteoporosis, a common condition characterized by reduced bone mass and increased fracture risk. The vitamin D receptor (VDR) gene has been suggested as a possible candidate gene for the regulation of bone mass but the relationship between VDR polymorphisms and bone mineral density (BMD) is controversial and has not been confirmed by all workers in different ethnic groups studied.


METHODS
In order to evaluate the contribution of the VDR alleles in bone mass loss, the BsmI, ApaI and TaqI polymorphisms in the VDR gene were studied in 126 postmenopausal women.


RESULTS
It was found that the bb, aa and TT genotypes and the bAT and baT haplotypes were associated with a lower BMD measured at the forearm.


CONCLUSIONS
Our analysis reveals a significant association between VDR gene alleles and bone mass in the population studied.
Douroudis
K
K
Department of Immunology and Histocompatibility, Evangelismos Hospital, Athens, Greece. drkmb@email.com
Tarassi
K
K
Ioannidis
G
G
Giannakopoulos
F
F
Moutsatsou
P
P
Thalassinos
N
N
Papasteriades
Chr
C
D015519:Bone Density / Q000235:genetics*; D005260:Female; D006801:Humans; D011110:Polymorphism, Genetic; D017698:Postmenopause / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*
D018167:Receptors, Calcitriol