Curbing the excesses of youth: molecular insights into axonal pruning.
The embryonic nervous system is refined over the course of development as a result of the twin processes of naturally occurring cell death and selective axon pruning. Recent studies provide new insights into the molecular events that underlie axon pruning and underscore the diversity of refinement processes employed by the nervous system during development.
Kantor
David B
DB
Department of Neuroscience, The Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. dkantor@jhmi.edu
Kolodkin
Alex L
AL
D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D006624:Hippocampus / Q000648:ultrastructure; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D009420:Nervous System / Q000196:embryology* / Q000648:ultrastructure; D009434:Neural Pathways / Q000196:embryology* / Q000648:ultrastructure; D009474:Neurons / Q000502:physiology / Q000648:ultrastructure
D009419:Nerve Tissue Proteins