title: [Duo-Bonharen--a new viscoelastic preparation. Experimental study].
abstract: The paper discusses preclinical tests of a new viscoelastic preparation for ophthalmosurgery. Experiments revealed that preparation Duo-Bonharen which contains hyaluronic acid prepared by bacterial fermentation is suited for clinical tests. After a 24-hour interval following administration into the anterior chamber it does not raise intraocular pressure. In experiments it has no side-effects on the eye. The dispersed form in a higher concentration (5%) adheres very well to ocular tissues and protects them adequately during surgery. The cohesive form in an optimal concentration (1.5%) can be rapidly removed from inside the eye. The properties of Duo-Bonharen in experiments are comparable with similar viscomaterials which are used. The new viscoelastic material Duo-Bonharen appears suitable for clinical tests in particular for cataract surgery.
authors.affiliation: Ocní klinika, Fakultní Nemocnice a Lékarská fakulta v Hradci Králové Univerzity Karlovy v Praze.
authors.forename: A
authors.initials: A
authors.lastname: al-Farzai
authors.forename: J
authors.initials: J
authors.lastname: Novák
authors.forename: F
authors.initials: F
authors.lastname: Hubálek
authors.forename: P
authors.initials: P
authors.lastname: Cesková
authors.forename: J
authors.initials: J
authors.lastname: Kvasnicka
authors.forename: F
authors.initials: F
authors.lastname: Langr
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D004548:Elasticity; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D008297:Male; D013508:Ophthalmologic Surgical Procedures; D011817:Rabbits; D014783:Viscosity
chemical_list: C475914:Duo-Bonharen; D006820:Hyaluronic Acid