Clinical assessment of hepatic functional reserve using 99mTc DTPA galactosyl human serum albumin SPECT to prognosticate chronic hepatic diseases--validation of the use of SPECT and a new indicator.
BACKGROUND
It is generally known that scintigraphy of 99mTc diethylenetriamine pentaacetic acid-galactosyl human serum albumin (99mTc-GSA) is useful for assessing hepatic functional reserve. For hepatic functional indicators, the index of the calculated planar image has been used in previous studies. However, there have been few reports that suggest that the indicators calculated from static SPECT data would be useful for the assessment of hepatic function. The aims of this study were to establish a simple method for assessing hepatic functional reserve using the liver SPECT of 99mTc-GSA and to apply this method for rich stratification in patients with chronic hepatic diseases.


METHODS
A liver phantom (a 50% concentration of 99mTc solution) was used to compare the planar and SPECT methods. According to the definition of the new indicator, the liver SPECT of 99mTc-GSA was divided by a syringe SPECT of 99mTc-GSA and was called the liver uptake ratio (LUR). We correlated the LUR and the liver uptake ratio calculated according to the blood-sampling method. 99mTc-GSA SPECT was performed in 137 patients with hepatic diseases, including chronic hepatic diseases, and 20 healthy volunteers. The LUR was correlated between the formed subtypes for all subjects.


RESULTS
The acquired phantom-count ratio calculated by the SPECT method was more accurate than that acquired by the planar method. A good correlation was obtained between the LUR and the blood-sampling method (r = 0.971). The LUR was significantly lower in subjects with severe cirrhosis than in healthy subjects or those with chronic hepatitis and mild cirrhosis, and it was significantly lower in subjects with chronic hepatitis and mild cirrhosis than in healthy subjects. The LUR was significantly correlated with other hepatic function tests. Based on LUR, the chronic hepatic diseases were divided into two groups: Group A, with LURs 30% and higher, and Group B, with LURs below 30%. An LUR of 30% marked the 25th percentile of the mild-cirrhosis group. The cumulative survival rates were lower in Group B than in Group A.


CONCLUSIONS
The SPECT method was superior to the planar method for assessing LURs. LUR was a suitable indicator of 99mTc-GSA clearance from the blood pool and of binding to the asialo-glycoprotein receptor. LUR is a simple and clinically useful indicator for the assessment of hepatic functional reserve in chronic hepatic diseases.
Onodera
Yuya
Y
Department of Radiology and Nuclear Medicine, Hokkaido University School of Medicine, Sapporo, Japan. y-ono@radi.med.hokudai.ac.jp
Takahashi
Kazuei
K
Togashi
Tadashi
T
Sugai
Yukio
Y
Tamaki
Nagara
N
Miyasaka
Kazuo
K
D002908:Chronic Disease; D003947:Diagnostic Techniques, Radioisotope; D006521:Hepatitis, Chronic / Q000097:blood / Q000000981:diagnostic imaging* / Q000401:mortality*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008103:Liver Cirrhosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000401:mortality*; D008107:Liver Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000453:epidemiology; D008111:Liver Function Tests / Q000379:methods*; D011379:Prognosis; D019275:Radiopharmaceuticals / Q000097:blood; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D013668:Technetium Tc 99m Aggregated Albumin / Q000097:blood; D016284:Technetium Tc 99m Pentetate / Q000097:blood; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; D016284:Technetium Tc 99m Pentetate