Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children.
We studied a cohort containing 368 children at high risk of developing atopy and atopic disorders and 540 parents of those children to investigate whether the IL13 Arg130Gln and C-1112 T polymorphisms were associated with these outcomes. We also investigated whether haplotypes consisting of any two polymorphisms of IL13 Arg130Gln, IL13 C-1112 T and IL4 C-589 T were associated with these phenotypes. In 288 white children, the IL13 130Gln allele was associated with atopy (RR=1.9, P=0.047), and with atopic dermatitis (RR=2.5, P=0.014). The associations were confirmed using a family-based test of association (P=0.027 and 0.030, respectively) in all subjects. In white subjects there were associations of haplotypes consisting of IL13 Arg130Gln and IL4 C-589 T with atopic dermatitis (P=0.006) and with atopy (P=0.009). Our data suggest that the IL13 Arg130Gln polymorphism and haplotypes consisting of IL13 Arg130Gln and IL4 C-589 T were associated with the development of atopy and atopic dermatitis at 24 months of age.
He
J-Q
JQ
McDonald Research Laboratories/iCAPTURE Center, St Paul's Hospital, University of British Columbia, Canada.
Chan-Yeung
M
M
Becker
A B
AB
Dimich-Ward
H
H
Ferguson
A C
AC
Manfreda
J
J
Watson
W T A
WT
Sandford
A J
AJ
D044466:Asian People; D002170:Canada; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000235:genetics*; D005787:Gene Frequency; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D011446:Prospective Studies; D012307:Risk Factors; D044465:White People
D018793:Interleukin-13; D015847:Interleukin-4