[Sabuco's suco nerveo and the origins of neurochemistry in the Spanish Renaissance].
BACKGROUND
In the 16th century, at the height of the Spanish Renaissance, Bachiller Miguel Sabuco revolutionised medical theories about brain physiology with the publication of his work Nueva Filosof a in 1587. This work, which is mysteriously attributed to his daughter Luisa Oliva, presents a surprisingly gynocentric ideology for its time and has been reprinted on numerous occasions since its first edition saw the light. Sabuco s ideas have been plagiarised by such renowned authors as Descartes, Willis and Glisson.


METHODS
In stark contrast to the Arabized galenism based on the criterion of authority that predominated the medical practice of his time, Nueva Filosof a empirically promoted a modern approach to neurophysiology. This becomes even more worthy of merit if we bear in mind that Sabuco was not trained as a doctor but instead worked as an apothecary in Alcaraz (Albacete, Spain). The Bachiller granted the brain a commanding role over the organisation of the body for the first time in the history of medicine. He not only developed the surprising theory of succo nervoso (the nervous sap, or original neurotransmitting substance), but also an elegant digression on human nature that puts forward solid arguments about the dualist relation between mind and brain. He examined the association between emotional and physical health and explained how the emotions can impair health and lead to early death, which means he was also a pioneer in the development of psychosomatic medicine.


CONCLUSIONS
Besides constituting the most illustrious forerunner of modern day neurochemistry, Sabuco s work also encourages doctors to treat their patients in an integral manner, with equal attention being given to the body, mind and soul. It comes as no surprise, then, that many aspects of his work can still be compared to modern medical and philosophical thought.
Martin Araguz
A
A
Hospital Central de la Defensa, Servicio de Neurología, Madrid, España. amartina@medynet.com
Bustamante Martinez
C
C
Fernandez Armayor
V
V
D001877:Books; D049669:History, 16th Century; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009448:Neurochemistry / Q000266:history*; D009482:Neurophysiology / Q000266:history; D010686:Philosophy, Medical; D010820:Physicians / Q000266:history; D013030:Spain; D009435:Synaptic Transmission / Q000502:physiology*