DNA replication: a complex matter.
In eukaryotic cells, the essential function of DNA replication is carried out by a network of enzymes and proteins, which work together to rapidly and accurately duplicate the genetic information of the cell. Many of the components of this DNA replication apparatus associate with other cellular factors as components of multiprotein complexes, which act cooperatively in networks to regulate cell cycle progression and checkpoint control, but are distinct from the pre-replication complexes that associate with the origins and regulate their firing. In this review, we summarize current knowledge about the composition and dynamics of these large multiprotein complexes in mammalian cells and their relationships to the replication factories.
Frouin
Isabelle
I
Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, via Abbiategrasso 207, I-27100 Pavia, Italy.
Montecucco
Alessandra
A
Spadari
Silvio
S
Maga
Giovanni
G
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D004261:DNA Replication / Q000235:genetics; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D009097:Multienzyme Complexes / Q000378:metabolism; D018741:Replication Origin / Q000235:genetics; D013539:Simian virus 40 / Q000235:genetics; D000099272:Replisomes
D004259:DNA-Directed DNA Polymerase; D009097:Multienzyme Complexes; D000099272:Replisomes