title: Development and validation of a high-performance liquid chromatography assay for voriconazole.
abstract: An analytical method for the determination of voriconazole (UK-109,496; Pfizer) in plasma was developed and validated. The method utilizes solid-phase extraction technology and high-performance liquid chromatography. The lower limit of quantitation is 0.2 microg/ml, and the range of linearity tested was 0.2 to 10 microg/ml.
authors.affiliation: Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA. pennick@uthscsa.edu
authors.forename: Gennethel J
authors.initials: GJ
authors.lastname: Pennick
authors.forename: Martin
authors.initials: M
authors.lastname: Clark
authors.forename: Deanna A
authors.initials: DA
authors.lastname: Sutton
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rinaldi
mesh_terms: D000935:Antifungal Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods* / Q000592:standards; D011743:Pyrimidines / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014230:Triazoles / Q000032:analysis*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole