Early prediction of the sensitivity of warfarin in elderly patients by the fall in factor VIIc and protein C at the induction of treatment.
Bertola
Jean Pierre
JP
Unité de Recherches Thérapeutiques, Hôpital Lariboisière, Paris, France. jpbertola@aol.com
Mazoyer
Elisabeth
E
Bergmann
Jean François
JF
Drouet
Ludovic
L
Simoneau
Guy
G
Mahé
Isabelle
I
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood; D000925:Anticoagulants / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D001777:Blood Coagulation / Q000187:drug effects*; D065729:Cytochrome P-450 CYP2C9; D004198:Disease Susceptibility; D005167:Factor VII / Q000032:analysis*; D005260:Female; D005838:Genotype; D006470:Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D011486:Protein C / Q000032:analysis*; D014859:Warfarin / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
D000925:Anticoagulants; D011486:Protein C; D014859:Warfarin; D005167:Factor VII; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases