title: [Kawasaki's disease with eruptive pustular and guttate psoriasis].
abstract: BACKGROUND
  Kawasaki's disease may have numerous atypical forms and these must be recognized in order to avoid delay of treatment. We report a case of psoriasis, first pustular and then guttate, occurring during Kawasaki's disease, and discuss a common pathophysiological mechanism.
  
  
  METHODS
  A 3 year-old boy was seen for a febrile exanthema suggestive of Kawasaki disease (bilateral conjunctivitis, red and fissured lips, palmoplantar erythema, scarlet fever-like rash and perineal desquamation) associated with pustular lesions. A biopsy specimen of a pustular area showed histological features consistent with the diagnosis of pustular psoriasis. No coronary abnormality was found. The child was treated with intravenous immunoglobulins (2 g/kg) and oral aspirin (60 mg/kg/d). All the symptoms disappeared and immediate follow-up was marked by the appearance of guttate psoriasis.
  
  
  CONCLUSIONS
  Onset of psoriatic lesions during Kawasaki disease has been reported in 12 cases, either in acute phase or in immediate follow-up. Coronary complications have been found in 4 of 5 cases with acute psoriasis, suggesting a severe prognosis for this association. The hypothesis of a common pathophysiological mechanism is discussed with the intervention of a bacterial toxin acting as a superantigen and resulting in an strong activation of T-cells that leads to keratinocyte activation. The psoriatic lesions could hence be considered as a form of Köbner's phenomenon.
authors.affiliation: Unité de Dermatologie Pédiatrique, Hôpital Pellegrin-Enfants, Place Amélie Raba-Léon, 33076 Bordeaux Cedex. frank.boralevi@chu-bordeaux.fr
authors.forename: F
authors.initials: F
authors.lastname: Boralevi
authors.forename: P
authors.initials: P
authors.lastname: Barat
authors.forename: S
authors.initials: S
authors.lastname: Lepreux
authors.forename: A-L
authors.initials: AL
authors.lastname: Stockman
authors.forename: A
authors.initials: A
authors.lastname: Taïeb
authors.forename: C
authors.initials: C
authors.lastname: Léauté-Labrèze
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D002081:Buttocks / Q000473:pathology; D002675:Child, Preschool; D005076:Exanthema / Q000209:etiology* / Q000473:pathology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000473:pathology*; D011565:Psoriasis / Q000209:etiology* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016756:Immunoglobulins, Intravenous; D001241:Aspirin