HIF, stretching to get control of VEGF.
Mechanical forces are key regulators of cell function, particularly of cells within the arterial wall that are exposed to the shear stress and pulsatile pressure of flowing blood. The finding by Chang and colleagues in this issue of Clinical Science that cell stretch can up-regulate the expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, which is a key regulator of blood vessel remodelling, provides us with further insight into the mechanisms underlying remodelling at sites of occlusive disease within the cardiovascular system.
Warner
Timothy D
TD
The William Harvey Research Institute, Barts and The London, Queen Mary's School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.
Mitchell
Jane A
JA
D000818:Animals; D001158:Arteries; D001696:Biomechanical Phenomena; D002468:Cell Physiological Phenomena; D016228:Endothelial Growth Factors / Q000235:genetics* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology* / Q000378:metabolism / Q000503:physiopathology; D005786:Gene Expression Regulation; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D008222:Lymphokines / Q000235:genetics* / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D014157:Transcription Factors; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors