title: UV-induced skin damage.
abstract: Solar radiation induces acute and chronic reactions in human and animal skin. Chronic repeated exposures are the primary cause of benign and malignant skin tumors, including malignant melanoma. Among types of solar radiation, ultraviolet B (290-320 nm) radiation is highly mutagenic and carcinogenic in animal experiments compared to ultraviolet A (320-400 nm) radiation. Epidemiological studies suggest that solar UV radiation is responsible for skin tumor development via gene mutations and immunosuppression, and possibly for photoaging. In this review, recent understanding of DNA damage caused by direct UV radiation and by indirect stress via reactive oxygen species (ROS) and DNA repair mechanisms, particularly nucleotide excision repair of human cells, are discussed. In addition, mutations induced by solar UV radiation in p53, ras and patched genes of non-melanoma skin cancer cells, and the role of ROS as both a promoter in UV-carcinogenesis and an inducer of UV-apoptosis, are described based primarily on the findings reported during the last decade. Furthermore, the effect of UV on immunological reaction in the skin is discussed. Finally, possible prevention of UV-induced skin cancer by feeding or topical use of antioxidants, such as polyphenols, vitamin C, and vitamin E, is discussed.
authors.affiliation: Division of Dermatology, Graduate School of Medicine, Translational Medicine, School of Medicine, Kobe University, Kobe, Japan. ichihash@med.kobe.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Ichihashi
authors.forename: M
authors.initials: M
authors.lastname: Ueda
authors.forename: A
authors.initials: A
authors.lastname: Budiyanto
authors.forename: T
authors.initials: T
authors.lastname: Bito
authors.forename: M
authors.initials: M
authors.lastname: Oka
authors.forename: M
authors.initials: M
authors.lastname: Fukunaga
authors.forename: K
authors.initials: K
authors.lastname: Tsuru
authors.forename: T
authors.initials: T
authors.lastname: Horikawa
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004249:DNA Damage; D004260:DNA Repair; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control; D017382:Reactive Oxygen Species / Q000009:adverse effects; D012878:Skin Neoplasms / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control; D013472:Sunlight / Q000009:adverse effects; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species