title: Ribosomal mutations conferring resistance to macrolides in Streptococcus pneumoniae clinical strains isolated in Germany.
abstract: Among a collection of 4281 pneumococcal isolates, 7 strains isolated in Germany had an unusual macrolide resistance phenotype. The isolates were found to have multiple mutations in the 23S rRNA and alterations in the L4 ribosomal protein. One strain had an amino acid alteration in the L22 ribosomal protein.
authors.affiliation: Institute of Medical Microbiology, National Reference Center for Streptococci, Aachen, Germany. reinert@rwth-aachen.de
authors.forename: Ralf René
authors.initials: RR
authors.lastname: Reinert
authors.forename: Angela
authors.initials: A
authors.lastname: Wild
authors.forename: Peter
authors.initials: P
authors.lastname: Appelbaum
authors.forename: Rudolf
authors.initials: R
authors.lastname: Lütticken
authors.forename: Murat Yücel
authors.initials: MY
authors.lastname: Cil
authors.forename: Adnan
authors.initials: A
authors.lastname: Al-Lahham
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005838:Genotype; D005858:Germany; D018942:Macrolides; D008969:Molecular Sequence Data; D017354:Point Mutation; D012338:RNA, Ribosomal, 23S / Q000235:genetics*; D012269:Ribosomal Proteins / Q000235:genetics*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D012338:RNA, Ribosomal, 23S; D012269:Ribosomal Proteins; C056368:ribosomal protein L4