title: Aortic valve replacement in patients with impaired ventricular function.
abstract: BACKGROUND
  Patients with reduced ventricular function undergoing aortic valve replacement have increased operative risks, but the impact of valvular pathophysiology and other risk factors has not been clearly defined.
  
  
  METHODS
  From June 1992 through June 2002, 1,402 consecutive patients underwent isolated aortic valve surgery with or without coronary artery bypass grafting; of these patients, 416 had an ejection fraction less than 40% and are the subject of this report. These patients (mean age, 68.6) had severe stenosis (62.5%), severe regurgitation (30.3%), or mixed disease (7.2%). Aortic valve replacement plus coronary artery bypass grafting was performed in 48.4% of patients, and 27% had previous cardiac surgery. Follow-up included echocardiography and survival analysis.
  
  
  RESULTS
  Hospital mortality was 10.1% (42 of 416), with no difference between aortic stenosis (9.6%) and regurgitation (11.1%). Multivariate analysis revealed that age (p = 0.002) and renal disease (odds ratio = 4.2; 95% confidence interval, 1.9 to 9.3; p = 0.001) were independently associated predictors of mortality. Valvular pathophysiology had no impact on mortality. Peripheral vascular disease, multivessel coronary disease, and renal disease were associated risks for any postoperative complication. Peripheral vascular disease (odds ratio = 12.3, p = 0.02), history of cerebrovascular disease (odds ratio = 4.8, p = 0.038), and diabetes (odds ratio = 2.7, p = 0.04) were associated risks for stroke. The ejection fraction was more than 40% in 52% of the patients who had postoperative echocardiography (mean follow-up, 6 months). Actuarial survival revealed no difference between pathophysiologic groups.
  
  
  CONCLUSIONS
  Aortic valve surgery in patients with impaired ventricular function carries an acceptable operative risk that can be stratified by age and comorbidities. The type of valvular pathophysiology does not significantly affect mortality.
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, New York University School of Medicine, New York, New York, USA.
authors.forename: Ram
authors.initials: R
authors.lastname: Sharony
authors.forename: Eugene A
authors.initials: EA
authors.lastname: Grossi
authors.forename: Paul C
authors.initials: PC
authors.lastname: Saunders
authors.forename: Charles F
authors.initials: CF
authors.lastname: Schwartz
authors.forename: Giovanni B
authors.initials: GB
authors.lastname: Ciuffo
authors.forename: F Gregory
authors.initials: FG
authors.lastname: Baumann
authors.forename: Julie
authors.initials: J
authors.lastname: Delianides
authors.forename: Robert M
authors.initials: RM
authors.lastname: Applebaum
authors.forename: Greg H
authors.initials: GH
authors.lastname: Ribakove
authors.forename: Alfred T
authors.initials: AT
authors.lastname: Culliford
authors.forename: Aubrey C
authors.initials: AC
authors.lastname: Galloway
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Colvin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000503:physiopathology / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D003131:Combined Modality Therapy; D015897:Comorbidity; D001026:Coronary Artery Bypass; D023921:Coronary Stenosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology; D012307:Risk Factors; D013318:Stroke Volume / Q000502:physiology; D016019:Survival Analysis; D018487:Ventricular Dysfunction, Left / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*