Pharmacogenetics in psychosis.
Pharmacogenetics uses genetic information to tailor drug treatment to the individual, maximizing clinical response and minimizing side effects. Failure to respond to medication and adverse side effects are common problems in psychiatry. Intolerable side effects can lead to discontinuation of medication. Individual genetic differences can determine both clinical responses to medications and the adverse side effects experienced. To fully predict clinical response to psychotropic drug treatment we must consider social, demographic and clinical factors such as compliance, social support and history of birth trauma, in addition to genetic influence on susceptibility and etiology.
Collier
David A
DA
Division of Psychological Medicine, The Institute of Psychiatry, London, UK. d.collier@iop.kcl.ac.uk
D014150:Antipsychotic Agents / Q000009:adverse effects / Q000378:metabolism* / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects / Q000378:metabolism* / Q000627:therapeutic use; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D004351:Drug Resistance / Q000235:genetics; D004409:Dyskinesia, Drug-Induced / Q000235:genetics; D006220:Haloperidol / Q000009:adverse effects / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects / Q000235:genetics
D014150:Antipsychotic Agents; D003577:Cytochrome P-450 Enzyme System; D003024:Clozapine; D006220:Haloperidol