title: Cardiovascular control by the suprachiasmatic nucleus: neural and neuroendocrine mechanisms in human and rat.
abstract: The risk for cardiovascular incidents is highest in the early morning, which seems partially due to endogenous factors. Endogenous circadian rhythms in mammalian physiology and behavior are regulated by the suprachiasmatic nucleus (SCN). Recently, anatomical evidence has been provided that SCN functioning is disturbed in patients with essential hypertension. Here we review neural and neuroendocrine mechanisms by which the SCN regulates the cardiovascular system. First, we discuss evidence for an endogenous circadian rhythm in cardiac activity, both in humans and rats, which is abolished after SCN lesioning in rats. The immediate impact of retinal light exposure at night on SCN-output to the cardiovascular system, which signals 'day' in both diurnal (human) and nocturnal (rat) mammals with opposite effects on physiology, is discussed. Furthermore, we discuss the impact of melatonin treatment on the SCN and its potential medical relevance in patients with essential hypertension. Finally, we argue that regional differentiation of the SCN and autonomous nervous system is required to explain the multitude of circadian rhythms. Insights into the mechanisms by which the SCN affects the cardiovascular system may provide new strategies for the treatment of disease conditions known to coincide with circadian rhythm disturbances, as is presented for essential hypertension.
authors.affiliation: Department of Hypothalamic Integration Mechanisms, Netherlands Institute for Brain Research, NL-1105 Amsterdam AZ, The Netherlands.
authors.forename: Frank A
authors.initials: FA
authors.lastname: Scheer
authors.forename: Andries
authors.initials: A
authors.lastname: Kalsbeek
authors.forename: Ruud M
authors.initials: RM
authors.lastname: Buijs
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D002940:Circadian Rhythm / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008027:Light; D008550:Melatonin / Q000502:physiology; D009490:Neurosecretory Systems / Q000502:physiology*; D051381:Rats; D013493:Suprachiasmatic Nucleus / Q000502:physiology*
chemical_list: D008550:Melatonin