title: Eudesmane derivatives from Laggera pterodonta.
abstract: A new eudesmane derivative, 4alpha,5alpha-dihydroxyeudesma-11(13)-en-12-oic acid, was isolated from Laggera pterodonta. Its structure was elucidated as (1) on the basis of spectroscopic evidence. Moreover, six known compounds were isolated: pterodontriol A (2), pterodontriol B, pterodonta acid (3), ilicic acid (4), costic acid and beta-amyrin. Cytotoxic activity of compounds 2, 3 and 4 was investigated.
authors.affiliation: Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China.
authors.forename: Yecheng
authors.initials: Y
authors.lastname: Xiao
authors.forename: Qunxiong
authors.initials: Q
authors.lastname: Zheng
authors.forename: Qijun
authors.initials: Q
authors.lastname: Zhang
authors.forename: Handong
authors.initials: H
authors.lastname: Sun
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D019659:Asteraceae; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045787:Sesquiterpenes, Eudesmane; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: C476870:4alpha,5alpha-dihydroxyeudesma-11(13)-en-12-oic acid; D000970:Antineoplastic Agents; D010936:Plant Extracts; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C015872:eudesmane