title: Eczematous skin disease and recall of past diagnoses: implications for smallpox vaccination.
abstract: BACKGROUND
  Persons with atopic dermatitis or eczema, regardless of disease severity or activity, may develop eczema vaccinatum if they or their close contacts receive the smallpox vaccine. According to current recommendations, a preexposure vaccination program should identify these persons and exclude them from participating.
  
  
  OBJECTIVE
  To determine the prevalence of diagnosed atopic dermatitis and eczema in a defined population and assess the sensitivity of screening questions to identify patients who have received these diagnoses.
  
  
  METHODS
  Population-based prevalence survey and telephone interview.
  
  
  METHODS
  14 ZIP code regions in Wisconsin.
  
  
  METHODS
  Persons given a diagnosis of atopic dermatitis or eczema in 2000 and 2001 were identified from a population-based cohort. Persons with a history of atopic dermatitis diagnosed since 1979 were eligible for the telephone survey.
  
  
  METHODS
  Prevalence of diagnosed atopic dermatitis or eczema; proportions of respondents able to recall a past diagnosis of atopic dermatitis, eczema, or recurrent rash.
  
  
  RESULTS
  The prevalence of atopic dermatitis or eczema diagnosis in 2000 or 2001 was 0.8%. At least 2.4% of the cohort would be ineligible for smallpox vaccination because of active skin disease in themselves or household members. Among 94 adult respondents with atopic dermatitis, 55 (59%) correctly self-reported skin disease. Seventy-nine (60%) of 133 household contacts of adults with atopic dermatitis correctly reported the presence of skin disease in a household member. Parental recall of skin disease in children with atopic dermatitis was 70% (123 of 177).
  
  
  CONCLUSIONS
  Identifying dermatologic contraindications to smallpox vaccination by relying only on a self-reported history of rash illnesses is likely to miss a substantial proportion of individuals who should not receive smallpox vaccine in a preexposure vaccination campaign.
authors.affiliation: Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA.
authors.forename: Allison L
authors.initials: AL
authors.lastname: Naleway
authors.forename: Edward A
authors.initials: EA
authors.lastname: Belongia
authors.forename: Robert T
authors.initials: RT
authors.lastname: Greenlee
authors.forename: Burney A
authors.initials: BA
authors.lastname: Kieke
authors.forename: Robert T
authors.initials: RT
authors.lastname: Chen
authors.forename: David K
authors.initials: DK
authors.lastname: Shay
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D000075202:Contraindications; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000453:epidemiology*; D004485:Eczema / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007407:Interviews as Topic / Q000379:methods; D007617:Kaposi Varicelliform Eruption / Q000209:etiology; D011939:Mental Recall; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012900:Smallpox Vaccine / Q000009:adverse effects; D013689:Telephone; D014611:Vaccination / Q000009:adverse effects; D014922:Wisconsin / Q000453:epidemiology
chemical_list: D012900:Smallpox Vaccine