Novel actions of leptin in the hippocampus.
It is well established that the obese gene product, leptin is an important circulating satiety factor that signals nutritional status to specific hypothalamic nuclei involved in body weight regulation. However, evidence is accumulating that, in addition to its pivotal role as an adiposity signal, leptin is a multi-faceted hormone that plays an important role in a plethora of CNS functions. In this review we summarize the recent advances made in leptin biology, with particular focus on its potential role as a cognitive enhancer and antiepileptic agent in the hippocampus.
Harvey
Jenni
J
Department of Pharmacology & Neuroscience, Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK. j.z.harvey@dundee.ac.uk
D000818:Animals; D015870:Gene Expression / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D020738:Leptin / Q000494:pharmacology / Q000502:physiology*; D051379:Mice; D023421:Models, Animal; D009474:Neurons / Q000187:drug effects; D018697:Nootropic Agents / Q000494:pharmacology; D009765:Obesity / Q000235:genetics; D051381:Rats; D011956:Receptors, Cell Surface / Q000502:physiology; D018121:Receptors, Cytokine / Q000502:physiology; D054411:Receptors, Leptin; D015398:Signal Transduction / Q000502:physiology
C515448:LEPR protein, human; D020738:Leptin; D018697:Nootropic Agents; D011956:Receptors, Cell Surface; D018121:Receptors, Cytokine; D054411:Receptors, Leptin; C515447:leptin receptor, mouse