title: Effects of carrageenans on the binding, phagocytotic, and killing abilities of macrophages to salmonella.
abstract: The effects of carrageenans (CGNs) on the host defense mechanisms of macrophages against Salmonella infection were examined in vitro by using macrophage-like J774.1 cells. Iota-CGN reduced the Salmonella-binding and phagocytotic activities of J774.1 cells, but it increased the killing activity of the cells. Kappa-CGN increased the binding activity, but reduced the killing ability. CGNs would affect the host defense mechanisms by modulating the macrophage functions.
authors.affiliation: Division of Microbiology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Sugita-Konishi
authors.forename: Shusaku
authors.initials: S
authors.lastname: Yamashita
authors.forename: Fumio
authors.initials: F
authors.lastname: Amano
authors.forename: Makoto
authors.initials: M
authors.lastname: Shimizu
mesh_terms: D000818:Animals; D002351:Carrageenan / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005503:Food Additives / Q000627:therapeutic use; D007700:Kinetics; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects*; D012475:Salmonella / Q000276:immunology*
chemical_list: D005503:Food Additives; D002351:Carrageenan