title: Bisphenol A influences the plasma calcium level and inhibits calcitonin secretion in goldfish.
abstract: In teleosts, it is well known that plasma calcium levels increase as a result of treatment with estrogen for at least during 2 weeks and that calcitonin secretion is induced by estrogen. The present study examined the influence of bisphenol A on calcium homeostasis in goldfish and compared the above known estrogenic action. In goldfish kept in water containing bisphenol A (10(-6) M), the plasma calcium concentration increased significantly (P<0.001) at 4 days but decreased significantly (P<0.05) at 8 days. By the treatment of bisphenol A, calcitonin secretion was not induced until 4 days. At 8 days, however, plasma calcitonin, as well as calcium, decreased significantly (P<0.05), although vitellogenin was detected in the plasma. Therefore, bisphenol A influences plasma calcium levels, but its action is different from that of estrogen, which indicates that bisphenol A affects the calcium homeostasis and might bring about abnormal conditions in teleosts.
authors.affiliation: Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Japan. nobuo@kenroku.kanazawa-u.ac.jp
authors.forename: Nobuo
authors.initials: N
authors.lastname: Suzuki
authors.forename: Akira
authors.initials: A
authors.lastname: Kambegawa
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Hattori
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds; D002116:Calcitonin / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology*; D005260:Female; D006054:Goldfish / Q000502:physiology; D006706:Homeostasis; D010636:Phenols / Q000494:pharmacology*; D014819:Vitellogenins / Q000032:analysis; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D002116:Calcitonin; D002118:Calcium; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D014819:Vitellogenins; C006780:bisphenol A; D000098826:Bisphenol A Compounds