title: A botulism case of a 12-year-old girl caused by intestinal colonization of Clostridium botulinum type Ab.
abstract: We encountered a 12-year-old girl, who had contracted food-borne botulism, and subsequently suffered from obstinate constipation for more than half a year. Even on hospital day 122, Clostridium botulinum and its toxin were detected in her stool specimens. The potency of the toxin of the blood serum sampled before treatment was 20 mouse minimum lethal dose per ml. The toxin in the blood had a molecular size equivalent to that of type A botulinum neurotoxin. On hospital day 250, the patient's serum detoxified type A neurotoxin. We confirmed that the patient had food-borne botulism caused by C. botulinum type Ab, followed by intestinal colonization-type botulism.
authors.affiliation: Department of Pediatrics, Jikei University School of Medicine, Kashiwa Hospital, Chiba 277-0004, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Kohji
authors.initials: K
authors.lastname: Fujisawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Saito
authors.forename: Makoto
authors.initials: M
authors.lastname: Kamijo
authors.forename: Sakiko
authors.initials: S
authors.lastname: Oshima
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Kubo
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Eto
authors.forename: Chie
authors.initials: C
authors.lastname: Monma
authors.forename: Masaru
authors.initials: M
authors.lastname: Kitamura
mesh_terms: D001905:Botulinum Toxins / Q000276:immunology; D001906:Botulism / Q000175:diagnosis* / Q000382:microbiology; D002648:Child; D003014:Clostridium botulinum / Q000145:classification* / Q000302:isolation & purification*; D003248:Constipation / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology*
chemical_list: D001905:Botulinum Toxins