title: Bioactivity of gel-glass powders in the CaO-SiO2 system: a comparison with ternary (CaO-P2O5-SiO2) and quaternary glasses (SiO2-CaO-P2O5-Na2O).
abstract: Bioactive glasses react chemically with body fluids in a manner that is compatible with the repair processes of the tissues. This results in the formation of an interfacial bond between the glasses and living tissue. Bioactive glasses also stimulate bone-cell proliferation. This behavior is dependent on the chemical composition as well as the surface texture of the glasses. It has been recently reported that gel-derived monolith specimens in the binary SiO2 - CaO are bioactive over a similar molar range of SiO2 content as the previously studied ternary CaO-P2O5-SiO2 system. In this report, the preparation and bioactivity of the binary gel-glass powder with 70 mol % SiO2 is discussed and its bioactivity is compared with the melt-derived 45S5 (quaternary) Bioglass and sol-gel-derived 58S (ternary) bioactive gel-glass compositions. Dissolution kinetic parameters K(1) and K(2) were also computed based on the silicon release for all glass powders. It was shown that the simple two-component SiO2-CaO gel-glass powder is bioactive with comparable dissolution rates as the clinically used melt-derived 45S5 Bioglass powder and extensively studied sol-gel-derived 58S gel-glass powder.
authors.affiliation: Tissue Engineering Centre, Department of Materials, Imperial College of Science, Technology and Medicine, Prince Consort Road, London SW7 2BP, United Kingdom. p.pavan@ic.ac.uk
authors.forename: Priya
authors.initials: P
authors.lastname: Saravanapavan
authors.forename: Julian R
authors.initials: JR
authors.lastname: Jones
authors.forename: Russell S
authors.initials: RS
authors.lastname: Pryce
authors.forename: Larry L
authors.initials: LL
authors.lastname: Hench
mesh_terms: D001031:Apatites / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids; D002516:Ceramics / Q000737:chemistry*; D005782:Gels; D005898:Glass / Q000737:chemistry*; D007700:Kinetics; D008422:Materials Testing; D010316:Particle Size; D016062:Porosity; D011208:Powders; D012822:Silicon Dioxide / Q000737:chemistry; D012995:Solubility; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D005782:Gels; D011208:Powders; D012996:Solutions; C425330:bioactive glass 45S5; C448994:bioactive glass 58S; C416205:calcium oxide-silicon dioxide-diphosphorus pentoxide glass; D012822:Silicon Dioxide