Neuromorphological background of cannabis addiction.
The expression of central cannabinoid (CB1) receptors in tyrosine hydroxylase (TH) containing neurones was demonstrated. Co-localisation was present in different brain areas responsible for reward-related mechanisms. The immunohistochemical investigations have shown that co-localisation is present in parts of mesolimbic-mesocortical dopaminergic system like nucleus accumbens (Nacb), ventral tegmental area (VTA), in the striatum, pyriform cortex, respectively. The results suggest a functional role of CB1 receptors in cannabis addiction by acting directly on reward-related structures.
Wenger
Tibor
T
Department of Human Morphology and Developmental Biology, Semmelweis University, Tuzolto u. 58, PO Box 95, Budapest, Hungary. wenger@ana2.sote.hu
Moldrich
Gabriella
G
Furst
Susanna
S
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000201:enzymology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D014446:Tyrosine 3-Monooxygenase