Matrix reloaded to circulation hits the tumor target.
Proteolytic fragments of various components of the extracellular matrix exhibit antiangiogenic activity via interaction with endothelial cell surface integrins. Kalluri and coworkers (this issue of Cancer Cell) use gene-targeted mice to show a physiological role for a carboxy-terminal fragment of collagen IV in the regulation of tumor angiogenesis.
Wickström
Sara A
SA
Keski-Oja
Jorma
J
Alitalo
Kari
K
D000818:Animals; D024141:Collagen Type IV / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000378:metabolism*
D024141:Collagen Type IV; D020780:Matrix Metalloproteinase 9