title: Change in the concentration of vitamins C and E in rat tissues by paraquat administration.
abstract: Paraquat causes lung injury by oxidative stress. After 48 h of intraperitoneal administration of paraquat (50 mg/kg of body weight) to rats, the vitamin C concentration in the lungs was significantly decreased, while lung vitamin E content was increased after 12 h. These results indicate that vitamin C directly reflected the oxidative stress in the lungs.
authors.affiliation: Department of Food Science and Nutrition, Nara Women's University, Nara 630-8506, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Ikeda
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kumagai
authors.forename: Yuka
authors.initials: Y
authors.lastname: Nagano
authors.forename: Naoko
authors.initials: N
authors.lastname: Matsuzawa
authors.forename: Shosuke
authors.initials: S
authors.lastname: Kojo
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000378:metabolism*; D006540:Herbicides / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D010269:Paraquat / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D006540:Herbicides; D014810:Vitamin E; D010269:Paraquat; D001205:Ascorbic Acid