Amikacin alters auditory brainstem conduction time in newborns.
The purpose of this paper was to describe whether there are some relationships between amikacin serum levels and central conduction time in brainstem auditory evoked potentials (BAEP) within therapeutic range levels in newborns as index of drug toxicity in brainstem auditory centers in neonatally exposed infants. We performed a cross-sectional study to compare BAEP from 35 infants under amikacin administration and 24 control infants; both examinations were blinded to investigators. Bivariate and partial correlations were calculated between amikacin and BAEP measurements in treated infants. Amikacin determinations were within therapeutic levels. No clinical alterations in BAEP were found and no differences between amikacin-treated and control infants were found. Significant positive Pearson correlation between latency of I-III interwaves interval and amikacin Cmin serum levels was found and was present when calculations were controlled by partial correlations for gestational age at birth and Apgar score at 5 min. The findings suggest that increased amikacin levels in newborns are related to increased latencies in I-III interwave interval in infants, which may be an early index of brainstem effects of subclinical neurotoxicity of amikacin.
Poblano
Adrián
A
Department of Neurology, National Institute of Perinatology, Department of Neurological Rehabilitation, Metropolitan University at Xochimilco, Mexico. drdeaf@starmedia.com
Belmont
Aurora
A
Sosa
Jesús
J
Ibarra
Jorge
J
Vargas
Ana María
AM
Limón
Gloria
G
Martínez
Carlos
C
D000583:Amikacin / Q000009:adverse effects* / Q000097:blood; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000097:blood; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D015931:Intensive Care, Neonatal; D008297:Male
D000900:Anti-Bacterial Agents; D000583:Amikacin