Liquid antiadhesive product (Adcon-p) prevents post-operative adhesions within the intra-abdominal organs in a rat model.
OBJECTIVE
Postoperative adhesions mostly cleave to small bowel and lead to troublesome problems. This study evaluated the effectiveness of a novel liquid antiadhesive product (Adcon-P) in rats.


METHODS
Thirty-eight Sprague Dawley rats underwent laparotomy during which the surgeon created abrasions on five different small bowel locations and the cecum in order to generate adhesions. Rats were randomly assigned to receive Adcon-P ( n=19) or to a control group ( n=19). The animals were killed on postoperative day 21. An observer blinded to the randomization assessed the difficulty of adhesiolysis with a six-point scoring system, recorded locations of adhesions and, noted the presence of serosal and full-thickness injuries. The total number of adhesions was also chronicled.


RESULTS
The severity of adhesion and adhesion scores were significantly lower in animals receiving Adcon-P. More animals suffered full-thickness and serosal injuries in the control group. The adhesions between small bowel segments and the number of adhesions attached to the small bowel were significantly lower in animals that received Adcon-P.


CONCLUSIONS
Adcon-P leads to an easier adhesiolysis and lessens the risk of bowel injury during relaparotomy. In particular, Adcon-P reduces the probability that adhesions specifically attach to the small bowel.
Oncel
Mustafa
M
Department of Colorectal Surgery, Cleveland Clinic Foundation, 9500 Euclid Avenue A30, Cleveland, OH 4195, USA.
Remzi
Feza H
FH
Senagore
Anthony J
AJ
Connor
Jason T
JT
Fazio
Victor W
VW
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005782:Gels / Q000494:pharmacology*; D007410:Intestinal Diseases / Q000209:etiology*; D007421:Intestine, Small / Q000293:injuries / Q000473:pathology* / Q000601:surgery; D007813:Laparotomy; D009930:Organic Chemicals; D011183:Postoperative Complications / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012720:Severity of Illness Index; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control
C472115:Adcon-P; D005782:Gels; D009930:Organic Chemicals