SPA: Simple web tool to assess statistical significance of DNA patterns.
Many statistical methods and programs are available to compute the significance of a given DNA pattern in a genome sequence. In this paper, after outlining the mathematical background of this problem, we present SPA (Statistic for PAtterns), an expert system with a simple web interface designed to be applied to two of these methods (large deviation approximations and exact computations using simple recurrences). A few results are presented, leading to a comparison between the two methods and to a simple decision rule in the choice of that to be used. Finally, future developments of SPA are discussed. This tool is available at the following address: http://stat.genopole.cnrs.fr/SPA/.
Richard
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Laboratoire Statistique et Genome, CNRS, INRA, Genopole, Université d'Evry Val d'Essone, 523 place des terrasses, 91000 Evry, France.
Nuel
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D003627:Data Interpretation, Statistical; D020407:Internet; D008390:Markov Chains; D012045:Regulatory Sequences, Nucleic Acid; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software; D014584:User-Computer Interface