[Changes in generation of superoxide anion-radical by phagocytic and other cells of atherosclerotic plaques at different stages of human atherosclerosis].
We investigated changes in generation of free radicals of oxygen including superoxide anion-radical (SAR) of oxygen by phagocytes and other cells of atherosclerotic plaques resected in operations of aortofemoral or aortoiliac bypass grafting and plastic vascular surgery of 38 patients with obliterating atherosclerosis obliterans of the lower extremities. We found some regularities in changes of SAR generation by phagocyting cells of atherosclerotic plaques at different morphological stages of their formation. Generation of the radicals progressively increased at the stage of fibrous plaques (1.56 times vs control), increased still more at the stage of their atheromatous alterations (2.3 times) and noticeably decreased at the stage of their calcinosis. Simultaneously, there was intensification of SAR formation by non-phagocyting cells of atherosclerotic plaques under their stimulation by NADPH-H (in fibrous and atheromatous plaques 1.3 and 2.0 times, respectively). On the contrary, at calcinosis stage NADPH-stimulated radical generation by these cells reduced.
Svetlova
N V
NV
Litvitskiĭ
P F
PF
Kogan
A Kh
AKh
D000328:Adult; D000368:Aged; D001011:Aorta / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D001161:Arteriosclerosis / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D002114:Calcinosis / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D066298:In Vitro Techniques; D015227:Lipid Peroxidation; D008875:Middle Aged; D009249:NADP / Q000494:pharmacology; D010586:Phagocytes / Q000378:metabolism*; D010587:Phagocytosis / Q000502:physiology*; D012016:Reference Values; D013481:Superoxides / Q000378:metabolism*
D013481:Superoxides; D009249:NADP