title: Obstinate thrombosis during percutaneous coronary intervention in a case with heparin-induced thrombocytopenia with thrombosis syndrome successfully treated by argatroban anticoagulant therapy.
abstract: We describe a case of massive coronary thrombus after the coronary stenting due to heparin-induced thrombocytopenia with thrombosis syndrome (HITTS). Only argatroban was able to resolve the thrombus. This is the first case in which argatroban successfully treated massive thrombus during percutaneous coronary intervention in a patient with HITTS.
authors.affiliation: Department of Cardiology, Niigata City General Hospital, Niigata, Japan. sakai@hosp.niigata.niigata.jp
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Sakai
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Oda
authors.forename: Akihiro
authors.initials: A
authors.lastname: Honsako
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Tutomu
authors.initials: T
authors.lastname: Miida
authors.forename: Norio
authors.initials: N
authors.lastname: Higuma
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000379:methods; D000925:Anticoagulants / Q000008:administration & dosage; D001120:Arginine / Q000031:analogs & derivatives; D006328:Cardiac Catheterization / Q000379:methods; D023921:Coronary Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D003328:Coronary Thrombosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005500:Follow-Up Studies; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D010875:Pipecolic Acids / Q000008:administration & dosage*; D011859:Radiography; D018570:Risk Assessment; D013449:Sulfonamides; D013577:Syndrome; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban