title: Wild-type measles virus induces large syncytium formation in primary human small airway epithelial cells by a SLAM(CD150)-independent mechanism.
abstract: In the natural course of measles virus (MV) infection, epithelial cells are primary targets of MV. However, it has been shown that wild-type MV utilizes signaling lymphocyte activation molecule (SLAM or CD150) as a cellular receptor, which is expressed only in some T and B cells, thymocytes, and dendritic cells. To understand how wild-type MV infects non-lymphoid cells, several non-lymphoid cells were examined for their susceptibility to wild-type MV. Here, we show that wild-type MV can infect primary human small airway epithelial cells (SAEC) and induce formation of large syncytia in vitro. mRNA specific for SLAM was not detected in SAEC, indicating that wild-type MV infects SAEC and induces syncytia formation via a SLAM-independent mechanism.
authors.affiliation: Department of Infection Biology, Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1 Tennodai, Ibaragi 305-8575, Tsukuba, Japan. ktakeuch@md.tsukuba.ac.jp
authors.forename: Kaoru
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Naoko
authors.initials: N
authors.lastname: Miyajima
authors.forename: Noriyo
authors.initials: N
authors.lastname: Nagata
authors.forename: Makoto
authors.initials: M
authors.lastname: Takeda
authors.forename: Masato
authors.initials: M
authors.lastname: Tashiro
mesh_terms: D015703:Antigens, CD; D001980:Bronchi / Q000166:cytology / Q000821:virology; D002460:Cell Line; D004847:Epithelial Cells / Q000821:virology; D015726:Giant Cells / Q000821:virology*; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D008168:Lung / Q000166:cytology / Q000821:virology; D008459:Measles virus / Q000502:physiology*; D011956:Receptors, Cell Surface; D011991:Receptors, Virus / Q000378:metabolism; D020545:Respiratory Mucosa / Q000166:cytology / Q000821:virology*; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D014407:Tumor Cells, Cultured
chemical_list: D015703:Antigens, CD; D006023:Glycoproteins; D007136:Immunoglobulins; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; C000604059:SLAMF1 protein, human; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1