title: Prevalence of SEN viruses among injection drug users in the San Francisco Bay area.
abstract: SEN viruses (SENVs) are newly discovered bloodborne viruses that may play a role in liver disease. SENV strain prevalence was examined in a race/ethnicity-stratified sample of 531 injection drug users (IDUs) from the San Francisco Bay area. Weighted prevalences were as follows: SENV-A, 45.7%; SENV-C/H, 35.6%; and SENV-D, 10.3%. Infection was associated with a longer duration of injection drug use. SENV-A was more common in black subjects (adjusted odds ratio [OR(a)], 4.37; 95% confidence interval [CI], 2.65-7.21) and Hispanic subjects (OR(a), 2.30; 95% CI, 1.38-3.85) than in white and non-Hispanic subjects, and the pattern was similar for SENV-C/H. For SENV-D, prevalence was similar in black and white subjects, but lower in Hispanic subjects; infection was less common among women than men (OR(a), 0.32; 95% CI, 0.15-0.71) and more common among men with at least 1 recent male sex partner than among heterosexual men (OR(a), 7.05; 95% CI, 2.62-18.95). SENV strains are common among San Francisco Bay area IDUs, and prevalence varies demographically within this group.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA.
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Pfeiffer
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Anthony E T
authors.initials: AE
authors.lastname: Yeo
authors.forename: Takeji
authors.initials: T
authors.lastname: Umemura
authors.forename: Karen H
authors.initials: KH
authors.lastname: Seal
authors.forename: J Wai-Kuo
authors.initials: JW
authors.lastname: Shih
authors.forename: Harvey J
authors.initials: HJ
authors.lastname: Alter
authors.forename: Brian R
authors.initials: BR
authors.lastname: Edlin
authors.forename: Thomas R
authors.initials: TR
authors.lastname: O'Brien
mesh_terms: D000328:Adult; D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D004266:DNA Virus Infections / Q000150:complications / Q000453:epidemiology* / Q000208:ethnology; D004267:DNA Viruses / Q000302:isolation & purification*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012495:San Francisco / Q000453:epidemiology; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000208:ethnology / Q000821:virology*; D044465:White People
chemical_list: D004279:DNA, Viral