title: Radionuclide imaging technologies and their use in evaluating asthma drug deposition in the lungs.
abstract: Whole lung and regional lung deposition of inhaled asthma drugs in the lungs can be quantified using either two-dimensional or three-dimensional radionuclide imaging methods. The two-dimensional method of gamma scintigraphy has been the most widely used, and is currently considered the industry standard, but the three-dimensional methods (SPECT, single photon emission computed tomography; and PET, positron emission tomography) give superior regional lung deposition data and will undoubtedly be used more frequently in future. Recent developments in radionuclide imaging are described, including an improved algorithm for assessing regional lung deposition in gamma scintigraphy, and a patent-protected radiolabelling method (TechneCoat), applicable to both gamma scintigraphy and SPECT. Radionuclide imaging data on new inhaled asthma products provide a milestone assessment, and the data form a bridge between in vitro testing and a full clinical trials program, allowing the latter to be entered with increased confidence.
authors.affiliation: Pharmaceutical Profiles Ltd, Mere Way, Ruddington Fields, Ruddington, Nottingham NG11 6JS, UK. snewman@pharmprofiles.co.uk
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Newman
authors.forename: Gary R
authors.initials: GR
authors.lastname: Pitcairn
authors.forename: Peter H
authors.initials: PH
authors.lastname: Hirst
authors.forename: Lisa
authors.initials: L
authors.lastname: Rankin
mesh_terms: D000280:Administration, Inhalation; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000503:physiopathology; D019275:Radiopharmaceuticals; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000295:instrumentation
chemical_list: D018927:Anti-Asthmatic Agents; D019275:Radiopharmaceuticals