title: Successful liver transplantation in a patient with sickle-cell anaemia.
abstract: Liver transplantation in the setting of sickle-cell anaemia poses several new challenges to the transplant team. Hypoxaemia, acidosis and a decrease in body temperature are common occurrences that can cause sickling in the peri-operative period, putting the patient at risk of sickle-cell crises or graft dysfunction. We describe a patient with sickle-cell anaemia who successfully underwent transplantation, and we discuss the rationale of various precautions that had to be taken.
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center of Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
authors.forename: Sven J
authors.initials: SJ
authors.lastname: van den Hazel
authors.forename: Herold J
authors.initials: HJ
authors.lastname: Metselaar
authors.forename: Hugo W
authors.initials: HW
authors.lastname: Tilanus
authors.forename: Jan N
authors.initials: JN
authors.lastname: IJzermans
authors.forename: Theo H N
authors.initials: TH
authors.lastname: Groenland
authors.forename: Loes
authors.initials: L
authors.lastname: Visser
authors.forename: Robert A
authors.initials: RA
authors.lastname: de Man
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D006501:Hepatic Encephalopathy / Q000150:complications* / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D011300:Preoperative Care; D016896:Treatment Outcome