title: Dietary mushroom (Pleurotus ostreatus) ameliorates atherogenic lipid in hypercholesterolaemic rats.
abstract: 1. The effects of edible oyster mushroom Pleurotus ostreatus on plasma and liver lipid profiles and on the plasma total anti-oxidant status were estimated in hyper- and normocholesterolaemic Long Evans rats. 2. The feeding of 5% powder of the fruiting bodies of P. ostreatus mushrooms to hypercholesterolaemic rats reduced their plasma total cholesterol by approximately 28%, low-density lipoprotein-cholesterol by approximately 55%, triglyceride by approximately 34%, non-esterified fatty acid by approximately 30% and total liver cholesterol levels by > 34%, with a concurrent increase in plasma high-density lipoprotein-cholesterol concentration of > 21%. However, these effects were not observed in mushroom-fed normocholesterolaemic rats. 3. Mushroom feeding significantly increased plasma fatty acid unsaturation in both normo- and hypercholesterolaemic rats. 4. Plasma total anti-oxidant status, as estimated by the oxidation of 2,2'-azino-bis-[3-ethylbenz-thiazoline-6-sulphonic-acid], was significantly decreased in mushroom-fed hypercholesterolaemic rats, concomitant with a decrease in plasma total cholesterol. 5. The present study suggests that 5% P. ostreatus supplementation provides health benefits, at least partially, by acting on the atherogenic lipid profile in the hypercholesterolaemic condition.
authors.affiliation: Department of Physiology, Shimane Medical University, Shimane, Japan.
authors.forename: Shahdat
authors.initials: S
authors.lastname: Hossain
authors.forename: Michio
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Emran Kabir
authors.initials: EK
authors.lastname: Choudhury
authors.forename: Nuhu
authors.initials: N
authors.lastname: Alam
authors.forename: Shahjalal
authors.initials: S
authors.lastname: Hussain
authors.forename: Moynul
authors.initials: M
authors.lastname: Hasan
authors.forename: Shahabuddin Kabir
authors.initials: SK
authors.lastname: Choudhury
authors.forename: Ishtiaq
authors.initials: I
authors.lastname: Mahmud
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002784:Cholesterol / Q000097:blood*; D005260:Female; D006937:Hypercholesterolemia / Q000097:blood* / Q000178:diet therapy*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D018514:Plant Structures; D020076:Pleurotus; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D000975:Antioxidants; D008055:Lipids; D002784:Cholesterol