title: [Influence of ivadal and depakene chrono on sleep structure in patients with epilepsy].
abstract: Because of strong association between epilepsy mechanisms and sleep disturbances, the latter may deteriorate the disease course and the patient's quality of life. Thirty eight patients with epilepsy (19 men and 19 women, mean age 25.6 +/- 11.4 years, age at onset 19.1 +/- 13.3 years, the disease duration 7.2 +/- 6.9 years) have been examined. The control group included 10 healthy individuals. The comparative group comprised 17 patients with physiological insomnia. All the patients had sleep disturbances of different level and were given hypnotic drug ivadal, which was compared to anticonvulsant depakine chrono, directly influencing GABA-ergic brain system. After sleep corrections, positive clinical and electroencephalographic trends in epileptic patients were detected. Comparing to depakine chrono, ivadal was suggested to up-regulate GABA-ergic brain systems during sleep due to rehabilitation of physiological brain characteristics.
authors.forename: Ia I
authors.initials: IaI
authors.lastname: Levin
authors.forename: B A
authors.initials: BA
authors.lastname: Tarasov
mesh_terms: D000328:Adult; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D004569:Electroencephalography; D004585:Electrooculography; D004827:Epilepsy / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D018682:GABA Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D010092:Oximetry; D017286:Polysomnography; D011725:Pyridines / Q000494:pharmacology* / Q000627:therapeutic use*; D012720:Severity of Illness Index; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis / Q000209:etiology*; D012894:Sleep Stages / Q000187:drug effects*; D014635:Valproic Acid / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D014851:Wakefulness / Q000187:drug effects; D000077334:Zolpidem
chemical_list: D003692:Delayed-Action Preparations; D018682:GABA Agents; D006993:Hypnotics and Sedatives; D011725:Pyridines; D014635:Valproic Acid; D000077334:Zolpidem