Acute metabolic effects of thiopental anesthesia on fed and fasted rats chronically treated with bromocriptine.
We investigated the acute effects of thiopental anesthesia (4 mg/100 g, i.v.) on plasma glucose, insulin, triacylglycerol, and prolactin levels in rats treated with bromocriptine (BR) (0.4 mg/100 g body wt, i.p., for two weeks). Thiopental anesthesia induced a rapid increase in plasma insulin that was more pronounced in the animals treated with BR (116%, P <0.05). Thiopental anesthesia also produced a 55% decreased in plasma prolactin levels (P <0.01) in control fed rats, and a 22% reduction in plasma triacylglycerol (P <0.05) in both controls and BR-treated rats. We conclude that BR may constitute and additional sympatholytic factor in animals submitted to thiopental anesthesia.
de Oliveira
Antônio Ribeiro
AR
Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil.
Botion
Leida Maria
LM
Guerra
Rachel Menezes
RM
Fóscolo
Rodrigo Bastos
RB
Machado
Lucas José Campos
LJ
Marubayashi
Umeko
U
dos Reis
Adelina Martha
AM
Coimbra
Cândido Celso
CC
D000758:Anesthesia / Q000379:methods*; D018686:Anesthetics, Intravenous; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001971:Bromocriptine / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005215:Fasting / Q000097:blood*; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D007328:Insulin / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013874:Thiopental
D018686:Anesthetics, Intravenous; D001786:Blood Glucose; D007328:Insulin; D001971:Bromocriptine; D011388:Prolactin; D013874:Thiopental