From molecules to behavior: new clues for RGS function in the striatum.
RGS proteins act as negative regulators of G protein signaling, and there is growing evidence that the RGS family is important for regulating signaling in neurons. Two articles in this issue of Neuron (Martemyanov et al. and Rahman et al.) shed light on the function of one family member, RGS9-2, in behavioral responses to dopamine signaling in the striatum and on the relationship between its structure and its function.
Burns
Marie E
ME
Center for Neuroscience and Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, CA 95616, USA.
Wensel
Theodore G
TG
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism / Q000494:pharmacology; D009474:Neurons / Q000502:physiology; D020710:RGS Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology; D015398:Signal Transduction; D013329:Structure-Activity Relationship
D020710:RGS Proteins; D011954:Receptors, Dopamine; C116925:regulator of g-protein signaling 9; D004298:Dopamine