Phospholipids, tumour marker and beta-CrossLaps in diagnosis of gastric carcinoma.
BACKGROUND
The aim of this study was to evaluate the effectiveness of the serum tumor marker levels of CEA, CA 19-9, CA 72-4 and beta-CrossLaps in gastric cancer patients. As an additional parameter, we investigated the membrane phospholipid profile of gastric cancer patients.


METHODS
We measured the tumor marker and phospholipid concentrations in 40 patients suffering from gastric cancer, 12 patients suffering from pancreatitis and 40 patients with gastric ulcera. We used the Elecsys 2010 enzyme analyser to determine the concentrations of CEA, CA 19-9, CA 72-4 and beta-CrossLaps. Phospholipid fractions were determined by HPLC.


RESULTS
Preoperative serum levels of CEA, CA 19-9 and CA 72-4 showed sensitivities of 47.5%, 68% and 76%, respectively. The sensitivity of beta-CrossLap was 63% for non-metastatic and 76% for metastatic gastric cancer. The phospholipid fraction of phosphatidyl ethanolamine showed elevated concentrations.


CONCLUSIONS
Additional prognostic information can be obtained using the combined assay of these tumor markers in gastric cancer patients.
Oremek
G M
GM
Klinikum der Johann-Wolfgang Goethe-Universität Frankfurt, Zentrallabor-Zentrum Innere Medizin, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany.
Sapoutzis
N
N
Lorenz
M
M
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D014408:Biomarkers, Tumor / Q000032:analysis*; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D024042:Collagen Type I / Q000097:blood*; D003937:Diagnosis, Differential; D006801:Humans; D010195:Pancreatitis / Q000175:diagnosis; D010743:Phospholipids / Q000032:analysis*; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000601:surgery; D013276:Stomach Ulcer / Q000175:diagnosis
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; C083825:CA-72-4 antigen; D002272:Carcinoembryonic Antigen; D024042:Collagen Type I; D010743:Phospholipids