title: Sample preparation, extraction efficiency, and determination of six arsenic species present in food composites.
abstract: Several sample preparation techniques were investigated to maximize the efficiency of arsenic species extraction from food composites. The optimized method includes lyophilization of food followed by prewashing with acetone and extraction by sonication with 50/50 methanol/water. Six arsenic species were separated and quantitated using an ammonium carbonate buffer system by ion exchange chromatography coupled to inductively coupled plasma mass spectrometry. The performance of the method for speciated arsenic components was evaluated using a matrix containing high fat food composite fortified with arsenic species. A certified reference material, dogfish muscle, was used to evaluate extraction methods for total arsenic content in food composites. More than 200 food composite samples were analyzed during an 18 month period, demonstrating the reliability of the analytical method over a long time period.
authors.affiliation: RTI International, 3040 Cornwallis Road, RTP, NC 27709-2194, USA. lmilstein@rti.org
authors.forename: Lisa S
authors.initials: LS
authors.lastname: Milstein
authors.forename: Amal
authors.initials: A
authors.lastname: Essader
authors.forename: Carlynn
authors.initials: C
authors.lastname: Murrell
authors.forename: Edo D
authors.initials: ED
authors.lastname: Pellizzari
authors.forename: Reshan A
authors.initials: RA
authors.lastname: Fernando
authors.forename: James H
authors.initials: JH
authors.lastname: Raymer
authors.forename: Olujide
authors.initials: O
authors.lastname: Akinbo
mesh_terms: D000096:Acetone; D001152:Arsenicals / Q000032:analysis*; D002852:Chromatography, Ion Exchange; D005504:Food Analysis / Q000379:methods*; D005612:Freeze Drying; D013058:Mass Spectrometry; D013010:Sonication
chemical_list: D001152:Arsenicals; D000096:Acetone