[Estimation of IGF-1 and IGFBP-3 concentrations in serum in children with diabetes type 1 and growth disorders].
The relations between diabetes type 1 and growth disturbances have been controversial. The aim of the study was to estimate the IGF-1 and IGFBP-3 levels in the group of children with diabetes type 1 and growth disturbances. The study group consisted of 22 children (10 males and 12 females) aged 11.96+/-3.38, bone aged 10.70+/-3.91, GV SDS < -0.93 below the mean for C. A. IGF-1, IGFBP-3, GH stimulation test, TSH, fT4 and HbA1 were determined. In the studied group positive correlations between: IGF-1 and IGFBP-3; IGF-1 and BMI; BMI and IGFBP-3 were determined. In children with diabetes type 1. The IGF-1 concentration was significantly higher when the sceletal age was delayed above 1 year in comparison with children with delaying of the sceletal age bellow 1 year and it was independent on results of GH stimulation tests.
Barg
E
E
Wikiera
B
B
Bieniasz
J
J
Wasikowa
R
R