An update on the genetics of Gilles de la Tourette syndrome.
OBJECTIVE
To summarize the current data suggesting that Gilles de la Tourette syndrome (GTS) is inherited and genetic.


METHODS
The extant literature on family studies, segregation analyses, candidate genes studies and linkage studies of GTS was reviewed and summarized.


CONCLUSIONS
There is considerable data that suggests that: (1). genetic factors play an important role in the manifestation of GTS; (2). several genes are important with some possibly having major effect; and (3). several regions of the genome have been identified as potential locations of these susceptibility genes.
Pauls
David L
DL
Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, 10th Floor, Charlestown, MA 02129, USA. pauls@psych.mgh.harvard.edu
D008040:Genetic Linkage; D005821:Genetic Techniques; D006801:Humans; D010375:Pedigree; D005879:Tourette Syndrome / Q000235:genetics*