Plasma volume expansion by medium molecular weight hydroxyethyl starch in neonates: a pilot study.
OBJECTIVE
To study the renal effects (measured by creatininemia) of plasma volume expansion with a medium molecular weight hydroxyethyl starch in the newborn.


METHODS
A prospective, randomized, double-blinded, pilot study.


METHODS
The study included 26 neonates weighing 690-4030 g (gestational age, 26-40 wks), without cardiac or renal failure or major hemostasis abnormalities and requiring a peripherally inserted central catheter for parenteral nutrition.


METHODS
Pediatric and neonatal intensive care unit of a university-affiliated hospital.


METHODS
Plasma volume expansion was performed to facilitate insertion of the central catheter. After parental consent, neonates were randomly allocated to receive intravenous infusions at 10 mL.kg(-1) of 5% albumin or 6% hydroxyethyl starch 200/0.5. Sample size was calculated to detect an increase in mean creatininemia of >20 micromol.L(-1) (with alpha = 0.05, beta = 0.80).


RESULTS
No clinically or statistically significant differences were found between the two groups 6 hrs, 24 hrs, 48 hrs, and 7 days after plasma volume expansion. The study could detect an increase in creatininemia > or =20 micromol.L(-1) with a power of 80%.


CONCLUSIONS
In 13 healthy neonates, plasma volume expansion with 10 mL.kg(-1) of 6% hydroxyethyl starch 200/0.5 does not increase creatininemia.
Liet
Jean-Michel
JM
Pediatric and Neonatal Critical Care Unit, University Hospital of Nantes, Nantes, France.
Bellouin
Anne-Sophie
AS
Boscher
Cécile
C
Lejus
Corinne
C
Rozé
Jean-Christophe
JC
D000367:Age Factors; D000418:Albumins / Q000008:administration & dosage / Q000494:pharmacology; D001802:Blood Substitutes / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage / Q000494:pharmacology*; D007231:Infant, Newborn; D007234:Infant, Premature; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008970:Molecular Weight; D010288:Parenteral Nutrition; D010865:Pilot Projects; D011446:Prospective Studies; D013997:Time Factors
D000418:Albumins; D001802:Blood Substitutes; D006895:Hydroxyethyl Starch Derivatives