The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats.
Adriamycin widely used in the treatment of neoplastic conditions is nephrotoxic. In the present study the protective effect of lipoic acid was investigated in adriamycin-induced nephrotoxicity in adult male albino Wistar rats. Adriamycin-induced nephrotoxicity was characterized by hyperlipidemia, proteinuria, and hypoproteinemia, by decreased activities of the enzymes N-acetyl-beta-D-glucosaminidase and cathepsin D, by increased lipid peroxidation and decreases in serum catalase and glutathione activities, and by increased urinary and serum urea, creatinine and urinary glycosaminoglycans. Pretreatment with lipoic acid restored the changes, indicating that lipoic acid is renoprotective in adriamycin nephrotoxicity.
Malarkodi
Kumaravel Palanichamy
KP
Department of Medical Biochemistry, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India.
Balachandar
Andithangal Venkatesan
AV
Varlakshmi
Palaninathan
P
D000118:Acetylglucosaminidase / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000097:blood / Q000187:drug effects; D002402:Cathepsin D / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D003404:Creatinine / Q000652:urine; D004317:Doxorubicin / Q000009:adverse effects*; D005978:Glutathione / Q000097:blood; D006025:Glycosaminoglycans / Q000378:metabolism; D006949:Hyperlipidemias / Q000139:chemically induced* / Q000150:complications / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000209:etiology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D020011:Protective Agents / Q000494:pharmacology; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000494:pharmacology*; D014280:Triglycerides / Q000378:metabolism; D014508:Urea / Q000097:blood
D000975:Antioxidants; D006025:Glycosaminoglycans; D020011:Protective Agents; D014280:Triglycerides; D008063:Thioctic Acid; D004317:Doxorubicin; D014508:Urea; D002784:Cholesterol; D003404:Creatinine; D002374:Catalase; D000118:Acetylglucosaminidase; D002402:Cathepsin D; D005978:Glutathione