Facile introduction of SH group on aromatic substrates via electrophilic substitution reactions.
Herein, we describe a mild and efficient two-step procedure to introduce a thiol group on aromatic substrates. First, reaction with an activated sulfoxide leads to an arylsulfonium salt intermediate. Then, two successive beta-elimination-based dealkylation reactions afford the desired arylthiols in good to excellent yields.
Becht
Jean-Michel
JM
Laboratoire de Synthèse Bioorganique, UMR 7514 associée au CNRS, Université Louis Pasteur de Strasbourg, Faculté de Pharmacie, 74 Route du Rhin, 67400 Illkirch, France.
Wagner
Alain
A
Mioskowski
Charles
C