Prioritizing the human genome: knowledge management for drug discovery.
This review covers recent methods to create a manageable subset of drug targets for development by prioritizing novel genes from the Human Genome Project. The ability to organize genomic data into a distinct set of drug discovery assets can be viewed as a form of knowledge management. While bioinformatics systems have been built to manage genomics-based data, the central theme in creating any bioinformatics infrastructure should be organization-specific knowledge management.
Golden
James B
JB
454 Corporation, 20 Commercial Street, Branford, CT 06405, USA. jgolden@454.com
D000818:Animals; D003628:Database Management Systems / Q000592:standards / Q000639:trends; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends; D015894:Genome, Human; D006801:Humans; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000592:standards / Q000639:trends