Analysis of the mouse transcriptome for genes involved in the function of the nervous system.
We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins. We also identified previously unknown candidates for secreted neuroactive molecules. The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored.A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.
Gustincich
Stefano
S
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA. gustinci@sissa.it
Batalov
Serge
S
Beisel
Kirk W
KW
Bono
Hidemasa
H
Carninci
Piero
P
Fletcher
Colin F
CF
Grimmond
Sean
S
Hirokawa
Nobutaka
N
Jarvis
Erich D
ED
Jegla
Tim
T
Kawasawa
Yuka
Y
LeMieux
Julianna
J
Miki
Harukata
H
Raviola
Elio
E
Teasdale
Rohan D
RD
Tominaga
Naoko
N
Yagi
Ken
K
Zimmer
Andreas
A
Hayashizaki
Yoshihide
Y
Okazaki
Yasushi
Y
D000225:Adenine / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001923:Brain Chemistry / Q000235:genetics; D002118:Calcium / Q000502:physiology; D015220:Calcium Channels / Q000235:genetics / Q000502:physiology; D018118:Chloride Channels / Q000235:genetics / Q000502:physiology; D003596:Cytosine / Q000378:metabolism; D030541:Databases, Genetic; D019204:GTP-Binding Proteins / Q000235:genetics; D015723:Gene Library; D005796:Genes / Q000235:genetics / Q000502:physiology*; D006147:Guanine / Q000378:metabolism; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009420:Nervous System / Q000737:chemistry* / Q000378:metabolism*; D009424:Nervous System Physiological Phenomena; D019636:Neurodegenerative Diseases / Q000235:genetics; D009474:Neurons / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D009479:Neuropeptides / Q000235:genetics; D010802:Phylogeny; D011956:Receptors, Cell Surface / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics*; D019680:Trinucleotide Repeat Expansion / Q000235:genetics
D015220:Calcium Channels; D018118:Chloride Channels; D009479:Neuropeptides; D011956:Receptors, Cell Surface; D006147:Guanine; D003596:Cytosine; D019204:GTP-Binding Proteins; D000225:Adenine; D002118:Calcium