Orlistat use in overweight women with mild hypercholesterolemia.
In the present study, we investigated the effects of a 6-month treatment with orlistat on body weight and lipid profile in 27 overweight women (mean body mass index [BMI]: 27.5 kg/m2; median age: 38.4 years) with mild hypercholesterolemia (total cholesterol: 225 mg/dl; low-density lipoprotein cholesterol [LDL-C]: 162 mg/dl). Orlistat was administered three times per day in conjunction with a hypocaloric diet After 6 months of treatment, body weight decreased by 17.71% and BMI decreased by 18.54%, whereas there was a significant (p < 0.01) improvement in serum lipid levels (total cholesterol: -25.33% LDL-C: -30.86%, high-density lipoprotein cholesterol: +9.37%, triglycerides: -35.97%). In conclusion, orlistat in combination with a low-energy diet seems to have a beneficial effect on body weight and lipid profile in overweight women with mild hypercholesterolemia.
Petrogiannopoulos
C
C
Hellenic Red Cross Hospital, Athens, Greece.
Kalogeropoulos
S
S
Latsios
G S
GS
Hartzoulakis
G
G
Kalogeropoulos
G
G
Zaharof
A
A
D000328:Adult; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000178:diet therapy / Q000188:drug therapy*; D007783:Lactones / Q000008:administration & dosage / Q000627:therapeutic use*; D008075:Lipoproteins, HDL / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000178:diet therapy / Q000188:drug therapy*; D000077403:Orlistat; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D019440:Anti-Obesity Agents; D008078:Cholesterol, LDL; D007783:Lactones; D008075:Lipoproteins, HDL; D014280:Triglycerides; D000077403:Orlistat