[Dynamic expression of antigen MG7 in the gastric cancer and gastric precancerous lesions].
OBJECTIVE
To study the kinetics of MG7 expression in the process of gastric cancer development.


METHODS
The expression level of antigen MG7 on gastric mucosa in 406 cases was determined by immunohistochemical techniques. The classification of intestinal metaplasia of gastric mucosa was determined by histochemistry techniques on gastric mucosa in 82 cases.


RESULTS
The positive rates of MG7 expression in normal gastric mucosa, intestinal metaplasia and dysplasia of gastric mucosa and gastric cancer all increased gradually (P < 0.01). The positive rates of MG7 expression in superficial gastritis, atrophic gastritis and gastric cancer increased in sequence (P < 0.01). The positive rate of antigen MG7 expression in III intestinal metaplasia of gastric mucosa was significantly different with I and II intestinal metaplasia (P < 0.05).


CONCLUSIONS
MG7 was quite specific in gastric cancer thus could be used as a good index in the screening of gastric cancer. Patients with III intestinal metaplasia of gastric mucosa, atrophic gastritis and dysplasia of gastric mucosa should be closely followed in order to improve the early detection on gastric cancer. It seemed that MG7 was clinically valuable in the dynamic follow-up of gastric precursors.
Guo
Dong-li
DL
Cancer Institute of The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Ning
Pei-fang
PF
Wang
Lan
L
Yuan
Yuan
Y
D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis*; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology
D000951:Antigens, Neoplasm