An unexpected and severe neurological disorder with permanent disability acquired during short-course treatment with metronidazole.
A case is reported of permanent sensorimotor distal polyneuropathy combined with sensory hemisymptoms in a middle-aged woman after only 10 g of metronidazole given as 400 mg, three times daily for 9 d. The disability is still permanent after 22 months of observation. No other cause has been found.
Rustscheff
S
S
Department of Internal Medicine, Värnamo General Hospital, Värnamo, Sweden. stefan.rustscheff@ltjkpg.se
Hulten
S
S
D002908:Chronic Disease; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008795:Metronidazole / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000503:physiopathology; D018570:Risk Assessment; D012720:Severity of Illness Index
D008795:Metronidazole