title: Synthesis and antimicrobial activity of novel globomycin analogues.
abstract: Globomycin, a signal peptidase II inhibitor, and its derivatives show potent antibacterial activity against Gram-negative bacteria. The synthesis and antimicrobial activity of novel globomycin analogues are reported. One of the analogues showed a more potent activity against Gram-negative bacteria than globomycin and also exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).
authors.affiliation: Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., 140-8710, Tokyo, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kiho
authors.forename: Mizuka
authors.initials: M
authors.lastname: Nakayama
authors.forename: Kayo
authors.initials: K
authors.lastname: Yasuda
authors.forename: Shunichi
authors.initials: S
authors.lastname: Miyakoshi
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Inukai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kogen
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D010455:Peptides; D011480:Protease Inhibitors; C017339:globomycin