title: Synthesis and biological properties of DNA-peptide conjugates.
abstract: Some naturally occurring nuclear localizing signals (NLSs) and some artificially designed peptides were covalently conjugated by solid phase fragment condensation (SPFC) method. These DNA-peptide conjugates showed enhanced permeability into cells as well as enhanced hybrid stability with ssDNA and dsDNA, and also higher resistance against nuclease digestion.
authors.affiliation: Department of Environmental and Biological Chemistry, Kyushu School of Engineering, Kinki University.
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: K
authors.initials: K
authors.lastname: Yokoyama
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.forename: K K
authors.initials: KK
authors.lastname: Dubey
authors.forename: M
authors.initials: M
authors.lastname: Fujii
mesh_terms: D001483:Base Sequence; D002463:Cell Membrane Permeability; D004247:DNA / Q000737:chemistry; D003850:Deoxyribonuclease I / Q000378:metabolism; D019913:Nuclear Localization Signals; D009693:Nucleic Acid Hybridization; D020319:Oligodeoxyribonucleotides, Antisense / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry*
chemical_list: D019913:Nuclear Localization Signals; D020319:Oligodeoxyribonucleotides, Antisense; D010455:Peptides; D004247:DNA; D003850:Deoxyribonuclease I