title: Longitudinal prospective evaluation of quality of life in adult patients before and one year after liver transplantation.
abstract: We assessed the impact of liver transplantation (LT) on the quality of life (QOL) of French recipients 1 year after surgery. A French version of the questionnaire used by the National Institute of Diabetes and Digestive and Kidney Disease-Pittsburg, USA (NIDDK), was validated by the back-translation method. Five QOL domains were evaluated: measures of disease, psychological distress, personal function, social function, and general health perception. Patients enrolled onto the waiting list completed the questionnaire before and 1 year after LT. Respondents were age- and gender-matched with healthy subjects recruited from the general population (GP). One year after LT, the analysis of data from 67 consecutive patients showed dramatic improvement in the five domains. Compared with baseline, patients noted fewer disease-related symptoms (P <.0001) and lower level of distress overall (P <.001). However, levels of distress caused by excess appetite (P <.01), trembling (P <.05), and headaches (P =.06) were more likely to increase than decrease. Twenty-five percent of patients prevented by their disease from going to work before LT were no longer so limited at 1-year follow-up. General health perception improved remarkably, with seven times as many recipients reporting improved health as reporting worse health. A correlation was found between the pretransplantation severity of cirrhosis and the social and role function after LT (P <.05). In summary, the French version of the NIDDK questionnaire seems to be reliable. The results of transplant recipients were generally close to those of the general population. Although it is not a true return to normal status, it approaches it.
authors.affiliation: Centre Hépatobiliaire, UPRES 1596, Assistance Publique-Hôpitaux de Paris, Université Paris Sud, Hôpital Paul Brousse, Villejuif, France. vincent.karam@ap.pbr-hop-paris.fr
authors.forename: Vincent
authors.initials: V
authors.lastname: Karam
authors.forename: Denis
authors.initials: D
authors.lastname: Castaing
authors.forename: Colette
authors.initials: C
authors.lastname: Danet
authors.forename: Valérie
authors.initials: V
authors.lastname: Delvart
authors.forename: Isabelle
authors.initials: I
authors.lastname: Gasquet
authors.forename: René
authors.initials: R
authors.lastname: Adam
authors.forename: Daniel
authors.initials: D
authors.lastname: Azoulay
authors.forename: Didier
authors.initials: D
authors.lastname: Samuel
authors.forename: Henri
authors.initials: H
authors.lastname: Bismuth
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D016031:Liver Transplantation / Q000523:psychology* / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D020127:Recovery of Function; D011795:Surveys and Questionnaires; D013997:Time Factors; D014850:Waiting Lists