Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis.
Four new ent-kaurane diterpenoids lushanrubescensins F-I (1-4), together with 11 known ones, lasiodonin (5), oridonin (6), ponicidin (7), isodonoiol (8), isodonal (9), rabdosin B (10), rabdoternins A and B (11 and 12), enmenol (13), epinodosin (14), and inflexusin (15), were isolated from Isodon rubescens var. lushanensis, and the structures were elucidated by spectroscopic analysis. The inhibitory effect against the K562, Bcap37, BGC823, BIU87, CA, CNE, and Hela cell lines of compounds 3 and 5-10 were evaluated.
Han
Quan-Bin
QB
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
Li
Ma-Lin
ML
Li
Sheng-Hong
SH
Mou
Yi-Kun
YK
Lin
Zhong-Wen
ZW
Sun
Han-Dong
HD
D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D037602:Isodon; D020014:K562 Cells; D000091402:Prohibitins
D004224:Diterpenes; D045786:Diterpenes, Kaurane; C000717331:PHB2 protein, human; D000091402:Prohibitins