Syntheses of two neuromedin U (NMU) analogues and their comparative reducing food intake effect in rats.
To examine the roles of aromatic rings Tyr residues at positions 1 and 6 and Phe residues at positions 16, 17 and 19 of rat neuromedin U-23 (NMU-23) (Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-Gly-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH(2)) for reducing food intake activity in male Wistar rats, two NMU-23 analogues, [Phe(4F)(16,17,19)]NMU-23 and [Tyr(Me)(1,6)]NMU-23, were synthesized by Fmoc strategy of manual solid-phase method. The synthetic NMU-23 showed reducing effect on food intake in rats. [Phe(4F)(16,17,19)]NMU-23 exhibited higher reducing food intake effect than that of NMU-23. On the contrary, [Tyr(Me)(1,6)]NMU-23 showed no reducing effect on food intake in rats than that of NMU-23.
Abiko
T
T
Research Laboratory, Global Shinwa Pharmaceutical Co. Ltd., Aoba-ku, Sendai, Japan. abiko@ma.mni.ne.jp
Takamura
Y
Y
D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D004435:Eating; D008297:Male; D009479:Neuropeptides / Q000737:chemistry* / Q000378:metabolism*; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D000596:Amino Acids; D009479:Neuropeptides; D010455:Peptides; C056900:neuromedin U