title: Two case studies of hypothermia induced by an increased dosage of zotepine in a combination therapy.
abstract: The purpose of the present paper was to remind physicians that hypothermia is a possible side-effect of combining zotepine, valproate,and benzodiazepine. Two cases of hypothermia occurred after combining the use of zotepine, valproate, and benzodiazepine. The valproate was under therapeutic blood level when zotepine dosage was raised to 200 mg/day, and hypothermia occurred. The dosage of zotepine might constitute a positive correlation with hypothermia. The combination of zotepine, valproate or benzodiazepine may cause hypothermia as a side-effect.
authors.affiliation: Department of Psychiatry, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan. andchenni@yahoo.com.tw
authors.forename: Kao Ching
authors.initials: KC
authors.lastname: Chen
authors.forename: Yen Kuang
authors.initials: YK
authors.lastname: Yang
authors.forename: Po See
authors.initials: PS
authors.lastname: Chen
authors.forename: Tzung Lieh
authors.initials: TL
authors.lastname: Yeh
authors.forename: Ming Jen
authors.initials: MJ
authors.lastname: Yang
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000009:adverse effects; D000927:Anticonvulsants / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy; D003975:Diazepam / Q000009:adverse effects; D003988:Dibenzothiepins / Q000008:administration & dosage* / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D007035:Hypothermia / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy; D014635:Valproic Acid / Q000009:adverse effects
chemical_list: D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D014150:Antipsychotic Agents; D003988:Dibenzothiepins; D014635:Valproic Acid; D003975:Diazepam; C022172:zotepine