Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients.
Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios. Ann Neurol 2003;54:119-122
Alizadeh
Mehdi
M
Laboratoire Universitaire d'Immunologie (UPRES EA 1257, IFR 97) and Etablissement Français du Sang Bretagne, Faculté de Médecine, Rennes, France.
Babron
Marie-Claude
MC
Birebent
Brigitte
B
Matsuda
Fumihiko
F
Quelvennec
Erwann
E
Liblau
Roland
R
Cournu-Rebeix
Isabelle
I
Momigliano-Richiardi
Patricia
P
Sequeiros
Jorge
J
Yaouanq
Jacqueline
J
Genin
Emmanuelle
E
Vasilescu
Alexandre
A
Bougerie
Héloise
H
Trojano
Maria
M
Martins Silva
Berta
B
Maciel
Patricia
P
Clerget-Darpoux
Françoise
F
Clanet
Michel
M
Edan
Gilles
G
Fontaine
Bertrand
B
Semana
Gilbert
G
D000069594:Abatacept; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics*; D060908:CTLA-4 Antigen; D015331:Cohort Studies; D017931:DNA Primers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D006801:Humans; D015151:Immunoblotting; D018796:Immunoconjugates; D009103:Multiple Sclerosis / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics
D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D017931:DNA Primers; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C106559:HLA-DR15 antigen; D018796:Immunoconjugates; D000069594:Abatacept