[Effects of bone morphogenetic protein and transforming growth fractor-beta on biomechanical property for fracture healing in rabbit ulna].
OBJECTIVE
To investigate the effects of exogenous bone morphogenetic protein (BMP) and transforming growth factor-beta (TGF-beta) on biomechanical property for ulna of fracture healing.


METHODS
Thirty-six adult rabbits were made the model of right ulnar fracture and treated locally with TGF-beta/PLA, BMP/PLA, TGF-beta + BMP/PLA or PLA (as control group). Fracture healing was evaluated by measurement of the mechanical parameters and geometric parameters.


RESULTS
As compared with control group, the geometric parameters, the bending broken load, the ultimate bending strength, the bending elastic modulus, the ultimate flexural strength, the flexural elastic modulus, the ultimate compressing strength, the compressing elastic modulus, and the ultimate tensile strength for ulna of fracture healing increased significantly in the treatment groups(P < 0.01). These parameters were higher in TGF-beta + BMP/PLA group than in TGF-beta/PLA group or in BMP/PLA group and in TGF-beta/PLA group than in BMP/PLA group(P < 0.05). There was no significant difference in bone density between the treatment groups and control group.


CONCLUSIONS
Local application of exogenous TGF-beta and BMP can increase the callus formation and enhance biomechanical strength of bone after fracture healing. A combination of TGF-beta and BMP has synergetic effect in enhancing fracture healing.
He
Xiao-bing
XB
Department of Orthopedics, Chongqing Fuling Central Hospital, Chongqing, P.R. China 408000.
Lu
Wei-zhong
WZ
Tang
Kang-lai
KL
Yang
Liu
L
He
Jing
J
Zhu
Qing-he
QH
Liu
Xiao-dong
XD
Xu
Jian-zhong
JZ
D000818:Animals; D001696:Biomechanical Phenomena; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005260:Female; D017102:Fracture Healing / Q000187:drug effects / Q000502:physiology*; D008297:Male; D011817:Rabbits; D016212:Transforming Growth Factor beta / Q000494:pharmacology*; D014458:Ulna Fractures / Q000188:drug therapy* / Q000503:physiopathology
D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta