Sfh-I, a subclass B2 metallo-beta-lactamase from a Serratia fonticola environmental isolate.
An environmental isolate of Serratia fonticola resistant to carbapenems was shown to contain a genetic determinant encoding a metallo-beta-lactamase of the subclass B2. The Sfh-I enzyme exhibits some divergence from the previously characterized enzymes of this subclass. This is the first example of a naturally occurring metallo-beta-lactamase in Enterobacteriaceae.
Saavedra
Maria José
MJ
Departmento de Higiene e Sanidade, ICETA, University of Trás-os-Montes e Alto Douro, Vila Real, Portugal.
Peixe
Luísa
L
Sousa
João Carlos
JC
Henriques
Isabel
I
Alves
Artur
A
Correia
António
A
D000595:Amino Acid Sequence; D015780:Carbapenems / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004777:Environment; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012705:Serratia / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
D015780:Carbapenems; D012336:RNA, Ribosomal, 16S; D001618:beta-Lactamases