title: The use of Raman spectroscopy to identify and grade prostatic adenocarcinoma in vitro.
abstract: Raman spectroscopy is an optical technique, which provides a measure of the molecular composition of tissue. Raman spectra were recorded in vitro from both benign and malignant prostate biopsies, and used to construct a diagnostic algorithm. The algorithm was able to correctly identify each pathological group studied with an overall accuracy of 89%. The technique shows promise as a method for objectively grading prostate cancer.
authors.affiliation: Cranfield Post-Graduate Medical School, Pullman Court, Gloucestershire Royal Hospital, Great Western Road, Gloucester, GL1 3NN, UK. paul_crow@hotmail.com
authors.forename: P
authors.initials: P
authors.lastname: Crow
authors.forename: N
authors.initials: N
authors.lastname: Stone
authors.forename: C A
authors.initials: CA
authors.lastname: Kendall
authors.forename: J S
authors.initials: JS
authors.lastname: Uff
authors.forename: J A M
authors.initials: JA
authors.lastname: Farmer
authors.forename: H
authors.initials: H
authors.lastname: Barr
authors.forename: M P J
authors.initials: MP
authors.lastname: Wright
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000473:pathology*; D000465:Algorithms; D001706:Biopsy; D006801:Humans; D008297:Male; D009367:Neoplasm Staging / Q000379:methods*; D011471:Prostatic Neoplasms / Q000145:classification / Q000473:pathology*; D012680:Sensitivity and Specificity; D013059:Spectrum Analysis, Raman