title: Serum inhibin B levels reflect contralateral testicular damage following unilateral testicular trauma.
abstract: BACKGROUND
  The aim of this study was to evaluate contralateral testicular damage (CTD) following unilateral blunt testicular trauma (BTT) and testicular capsule laceration (TCL) by the serum inhibin B level which is an accepted marker of spermatogenesis.
  
  
  METHODS
  Fifty peripubertal male Wistar albino rats were divided into 5 groups each containing 10 rats. Group 1 was the control group. Group 2 was the BTT group in which the right testicle was placed on a firm surface and a metal rod weighing 215 g was dropped onto the testicle from a height of 5.5 cm. Group 3 was the TCL group in which right testicular tunica albuginea was lacerated using the needle of 4/0 silk suture. Group 4 had right orchiectomy initially. Group 5 was the sham group. In all groups, 3-ml blood samples were taken and bilateral orchiectomies were performed 6 weeks after initial manipulations.
  
  
  RESULTS
  Groups 2 and 3 had decreased inhibin B levels (p < 0.001), although the orchiectomy group had normal levels. Histological analyses showed lower Johnsen scores for both trauma groups in the ipsilateral and contralateral testes (p < 0.05).
  
  
  CONCLUSIONS
  Serum inhibin B levels decrease following unilateral testicular trauma reflecting CTD.
authors.affiliation: Department of Pediatric Surgery, KSU Medical School, Kahramanmaras, Turkey. ozekin@hotmail.com
authors.forename: Keramettin Uğur
authors.initials: KU
authors.lastname: Ozkan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kücükaydin
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Muhtaroğlu
authors.forename: Olgun
authors.initials: O
authors.lastname: Kontaş
authors.forename: Fahri
authors.initials: F
authors.lastname: Karaca
mesh_terms: D000818:Animals; D015415:Biomarkers; D007265:Inhibins / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013091:Spermatogenesis; D013733:Testicular Diseases / Q000209:etiology / Q000378:metabolism*; D013737:Testis / Q000293:injuries*; D014947:Wounds and Injuries / Q000150:complications* / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C422364:inhibin B; D007265:Inhibins