Novel inhibitors of procollagen C-proteinase. Part 2: glutamic acid hydroxamates.
Glutamic acid derived hydroxamates were identified as potent and selective inhibitors of procollagen C-proteinase, an essential enzyme for the processing of procollagens to fibrillar collagens. Such compounds have potential therapeutic application in the treatment of fibrosis.
Robinson
L A
LA
CombiChem Inc., 4570 Executive Drive, 92121, San Diego, CA, USA.
Wilson
D M
DM
Delaet
N G J
NG
Bradley
E K
EK
Dankwardt
S M
SM
Campbell
J A
JA
Martin
R L
RL
Van Wart
H E
HE
Walker
K A M
KA
Sullivan
R W
RW
D055395:Bone Morphogenetic Protein 1; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005971:Glutamates / Q000138:chemical synthesis* / Q000494:pharmacology*; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007700:Kinetics; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000378:metabolism*; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D019485:Bone Morphogenetic Proteins; D005971:Glutamates; D006877:Hydroxamic Acids; D007202:Indicators and Reagents; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D008666:Metalloendopeptidases; D055395:Bone Morphogenetic Protein 1