title: Biomedical applications of electrostatic layer-by-layer nano-assembly of polymers, enzymes, and nanoparticles.
abstract: The introduction of electrostatic layer-by-layer (LbL) self-assembly has shown broad biomedical applications in thin film coating, micropatterning, nanobioreactors, artificial cells, and drug delivery systems. Multiple assembly polyelectrolytes and proteins are based on electrostatic interaction between oppositely charged layers. The film architecture is precisely designed and can be controlled to 1-nm precision with a range from 5 to 1000 nm. Thin films can be deposited on any surface including many widely used biomaterials. Microencapsulation of micro/nanotemplates with multilayers enabled cell surface modification, controlled drug release, hollow shell formation, and nanobioreactors. Both in vitro and in vivo studies indicate potential applications in biology, pharmaceutics, medicine, and other biomedical areas.
authors.affiliation: Department of Biomedical Engineering and Institute for Micromanufacturing, Louisiana Tech University, Ruston, LA 71272, USA.
authors.forename: Hua
authors.initials: H
authors.lastname: Ai
authors.forename: Steven A
authors.initials: SA
authors.lastname: Jones
authors.forename: Yuri M
authors.initials: YM
authors.lastname: Lvov
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D004798:Enzymes / Q000737:chemistry*; D008567:Membranes, Artificial; D008863:Microspheres; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D010316:Particle Size; D014677:Pharmaceutical Vehicles / Q000138:chemical synthesis; D011108:Polymers / Q000737:chemistry*; D019736:Prostheses and Implants; D055672:Static Electricity; D014159:Transducers
chemical_list: D020099:Coated Materials, Biocompatible; D004798:Enzymes; D008567:Membranes, Artificial; D014677:Pharmaceutical Vehicles; D011108:Polymers