[The role of nitric oxide and lipid peroxidation in bronchial obstruction in bronchial asthma].
Bronchoalveolar lavage (BAL) was studied in 16 patients with bronchial asthma. Overall metabolites of nitric oxide and malonic dialdehyde were measured. Correlations were established between the concentrations of biologically active compounds and lung ventilation in exacerbation and remission. Lipid peroxidation is closely related with inflammation in both the disease and in health, and is not related with disorders in lung ventilation. Nitric oxide metabolites are different: gas secretion in the exacerbation of bronchial asthma is higher than in chronic obstructive bronchitis. In remission, the nitric oxide activity is low, while it was higher in patients with bronchial asthma as compared with healthy persons.
Iuldasheva
I A
IA
Aripova
M I
MI
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D016084:Bronchoconstriction / Q000502:physiology*; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000032:analysis; D008875:Middle Aged; D009566:Nitrates / Q000032:analysis; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000032:analysis
D015415:Biomarkers; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D008315:Malondialdehyde