title: Outcomes and long-term survival for patients undergoing mitral valve repair versus replacement: effect of age and concomitant coronary artery bypass grafting.
abstract: BACKGROUND
  A paucity of literature is available on the effects of age and coronary artery bypass grafting (CABG) on the outcomes of patients undergoing mitral valve (MV) repair versus replacement.
  
  
  RESULTS
  A matched study was performed using prospectively collected data from the Emory cardiovascular database from 1984 to 1997 comparing 625 MV repair patients with 625 MV replacement patients. Mean age was significantly higher in the replacement group (56+/-14 versus 55+/-14 years). Preoperative demographics and postoperative outcomes were similar between groups. Length of stay (LOS) was significantly less in the repair group (9.5+/-9.4 versus 12.3+/-13.1 days). In-hospital mortality was significantly less in the repair group (4.3% versus 6.9%), and overall 10-year survival was significantly higher in the repair group (62% versus 46%). Ten-year survival of patients <60 years of age was significantly higher in repair patients (81% versus 55%) but similar in patients > or =60 years of age (33% versus 36%, respectively). Ten-year survival of MV repair without CABG was significantly higher compared with MV replacement patients (74% versus 51%) but similar to patients with concomitant CABG (28% versus 34%, respectively). Independent predictors of long-term mortality included increasing age, urgent/emergent status, female sex, diabetes mellitus, increasing weight, heart failure, decreasing ejection fraction, concomitant CABG, and MV replacement.
  
  
  CONCLUSIONS
  Mitral valve repair has reduced LOS and improved in-hospital and 10-year survival. However, in the present series, MV repair does not provide significant long-term survival benefit over MV replacement in patients older than 60 years of age or those requiring concomitant CABG.
authors.affiliation: Joseph B. Whitehead Department of Surgery, Division of Cardiothoracic Surgery, Carlyle Fraser Heart Center, Atlanta, Ga, USA.
authors.forename: Vinod H
authors.initials: VH
authors.lastname: Thourani
authors.forename: William S
authors.initials: WS
authors.lastname: Weintraub
authors.forename: Robert A
authors.initials: RA
authors.lastname: Guyton
authors.forename: Ellis L
authors.initials: EL
authors.lastname: Jones
authors.forename: Willis H
authors.initials: WH
authors.lastname: Williams
authors.forename: Sharif
authors.initials: S
authors.lastname: Elkabbani
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Craver
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D001026:Coronary Artery Bypass / Q000401:mortality / Q000706:statistics & numerical data*; D003324:Coronary Artery Disease / Q000401:mortality / Q000601:surgery; D019992:Databases as Topic; D005260:Female; D005845:Georgia / Q000453:epidemiology; D019918:Heart Valve Prosthesis Implantation / Q000401:mortality / Q000706:statistics & numerical data*; D017052:Hospital Mortality; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000401:mortality / Q000601:surgery*; D015999:Multivariate Analysis; D011446:Prospective Studies; D040841:Resource Allocation / Q000706:statistics & numerical data; D012720:Severity of Illness Index; D016019:Survival Analysis; D017741:Survivors / Q000706:statistics & numerical data*; D016896:Treatment Outcome