Invasive thymoma with paraneoplastic retinopathy.
A 60-year-old man was admitted for progressive visual loss in both eyes. He was diagnosed with retinopathy and chest computed tomography revealed an invasive thymoma. In western blot analysis, serum autoantibodies against recoverin, photoreceptor-specific calcium-binding protein, and heat shock cognate protein 70 which were identified as the cause of cancer-associated retinopathy (CAR). Immunofluorescence staining showed that thymoma cells also expressed recoverin. These observations strongly suggested that similar pathogenesis of CAR was involved in the presented case.
Yamada
Gen
G
Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
Ohguro
Hiroshi
H
Aketa
Katsuyuki
K
Itoh
Takayuki
T
Shijubo
Noriharu
N
Takahashi
Hiroki
H
Fujiwara
Osamutaro
O
Satoh
Masaaki
M
Ohtsuka
Kenji
K
Abe
Shosaku
S
D014408:Biomarkers, Tumor / Q000378:metabolism; D015153:Blotting, Western; D002135:Calcium-Binding Proteins / Q000378:metabolism; D005136:Eye Proteins; D016650:Fluorescein-5-isothiocyanate; D019084:Fluorescent Antibody Technique, Indirect; D051597:Hippocalcin; D006801:Humans; D008074:Lipoproteins; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009419:Nerve Tissue Proteins; D010257:Paraneoplastic Syndromes / Q000378:metabolism / Q000473:pathology*; D051603:Recoverin; D012164:Retinal Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D013934:Thymectomy; D013945:Thymoma / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D013953:Thymus Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; C496731:RCVRN protein, human; D051603:Recoverin; D051597:Hippocalcin; D016650:Fluorescein-5-isothiocyanate