Tubuloglomerular feedback and the control of glomerular filtration rate.
In every nephron the glomerular filtration rate is adapted to changes in the salt concentration of early distal tubular fluid through the mechanism of tubuloglomerular feedback. Recent studies indicate that adenosine and possibly ATP mediate this mechanism and demonstrate its role in glomerular hemodynamic alterations in the early diabetic kidney.
Vallon
Volker
V
Institute of Pharmacology and Toxicology, University of Tübingen, D-72074 Tübingen, Germany.
D000818:Animals; D025461:Feedback, Physiological / Q000502:physiology; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007678:Kidney Glomerulus / Q000502:physiology*; D007684:Kidney Tubules / Q000502:physiology*