title: Keloid-like scleroderma.
abstract: A 62-year-old female who developed concomitantly acrosclerosis and keloid-like lesions is described. Biopsy specimens from these linear lesions showed a fibrous proliferation in the dermis composed mostly of normal-appearing, horizontally oriented collagen bundles and myofibroblasts, thus resembling a scar. Keloidal scleroderma is a rare variant of scleroderma. The diagnosis is considered for patients with scleroderma who develop lesions clinically and histologically indistinguishable from keloids. This case demonstrates for the first time that the histopathologic findings can mimic those of a scar, rather than a keloid, and hence is appropriately designated as keloid-like scleroderma. Clinical pathological correlation is mandatory for the correct diagnosis.
authors.affiliation: Department of Dermatology, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel-Hashomer, Israel. avivb@post.tau.ac.il
authors.forename: Aviv
authors.initials: A
authors.lastname: Barzilai
authors.forename: Anna
authors.initials: A
authors.lastname: Lyakhovitsky
authors.forename: Ada
authors.initials: A
authors.lastname: Horowitz
authors.forename: Henri
authors.initials: H
authors.lastname: Trau
mesh_terms: D000199:Actins / Q000378:metabolism; D004547:Elastic Tissue / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007627:Keloid / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000150:complications / Q000378:metabolism / Q000473:pathology*
chemical_list: D000199:Actins