[Oxidative stress status in patients with various degrees of chronic renal insufficiency].
OBJECTIVE
To observe the changes of lipid peroxidation and antioxidative enzyme activities of chronic renal insufficiency (CRI) and to explore their effects on the pathogenesis of CRI.


METHODS
Serum levels of malondialdehyde (MDA), serum glutathione peroxidase (GSH-Px) and serum superoxide dismutase (SOD) in 36 non-dialyzed patients with various degrees and 12 hemodialyzed (HD) were determined with the method of chemistry colorimetry.


RESULTS
Thirty-six CRI and 12 HD patients included in the study had higher SOD activities when compared with the controls [(110.30+/-18.60) kNU/L]. They also had lower serum GSH-Px activity than the controls [(120.63+/-27.57) x 10(4)U/L]. Serum MDA levels in the patients were higher than that in the controls [(4.06+/-0.67) micromol/L]. Serum SOD, GSH-Px and MDA concentrations in 36 non-dialyzed patients with various degrees were also correlated with creatinine clearance (r(G)=0.68, P<0.01; r(M)=-0.52, P<0.01; r(S)=-0.44, P<0.05).


CONCLUSIONS
Free radicals, lipid peroxidation and the abnormality in antioxidative system may play an important role in the pathogenesis of CRI and correlated with impaired renal function, and that they can be regarded as important clinical indexes to infect the severity of chronic renal insufficiency.
Tu
Xiao-wen
XW
Department of Nephrology, General Hospital of Jinan Military Command, Jinan 250031, Shandong, China.
Niu
Ai-jun
AJ
Zhang
Ai-ping
AP
Wang
Yan-xia
YX
Ding
Yao-hai
YH
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000097:blood; D055815:Young Adult
D005609:Free Radicals; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase