Osteopontin: a bridge between bone and the immune system.
The molecular mechanisms underlying the putative role of osteopontin in the chronic inflammatory disease rheumatoid arthritis are unclear. A study in a murine model of arthritis now demonstrates that a specific antibody directed against the exposed osteopontin epitope SLAYGLR is capable of preventing inflammatory cell infiltration in arthritic joints.
Gravallese
Ellen M
EM
Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 241, 4 Blackfan Circle, Boston, Massachusetts 02115, USA. egravall@bidmc.harvard.edu
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000378:metabolism; D004195:Disease Models, Animal; D000939:Epitopes; D007249:Inflammation; D051379:Mice; D008810:Mice, Inbred C57BL; D053495:Osteopontin; D012333:RNA, Messenger / Q000378:metabolism; D012795:Sialoglycoproteins / Q000378:metabolism / Q000502:physiology*
D000939:Epitopes; D012333:RNA, Messenger; D012795:Sialoglycoproteins; C506896:Spp1 protein, mouse; D053495:Osteopontin