title: [Effect of antisperm antibodies on assisted reproduction].
abstract: The formation of antisperm antibodies (AsAb) results from the disruption of the blood-testis barrier by a variety of mechanisms, which leads to exposure of immunogenic sperm antigens to the immune system and initiates an immune response. AsAb can impair the fusion of sperm and egg and even the embryo development, resulting in infertility. The etiology of AsAb, effect of AsAb on assisted reproduction and treatment of AsAb in the literature are reviewed in this article.
authors.affiliation: Reproductive Medicine Research Center, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Ou
authors.forename: Guang-Lun
authors.initials: GL
authors.lastname: Zhuang
mesh_terms: D000906:Antibodies / Q000276:immunology*; D000917:Antibody Formation; D006801:Humans; D007248:Infertility, Male / Q000209:etiology; D008297:Male; D012099:Reproductive Techniques; D013094:Spermatozoa / Q000276:immunology*
chemical_list: D000906:Antibodies