Cytotoxic diterpenes from Scoparia dulcis.
Four new labdane-derived diterpenes, iso-dulcinol (1), 4-epi-scopadulcic acid B (2), dulcidiol (4), and scopanolal (5), together with two known diterpenes, dulcinol/scopadulciol (3) and scopadiol (6), were isolated from the aerial parts of Scoparia dulcis. The structures were determined by extensive NMR studies. The crude extracts as well as the pure diterpenes showed cytotoxicity against a panel of six human stomach cancer cell lines.
Ahsan
Monira
M
Department of Pharmacy and Institute of Nutrition and Food Science, University of Dhaka, Dhaka-1000, Bangladesh. monira@smpt.udhaka.net
Islam
S K N
SK
Gray
Alexander I
AI
Stimson
William H
WH
D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001459:Bangladesh; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D036721:Scoparia / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C071755:scopadulciol