Cell cycle: check for asynchrony.
During metazoan development cells destined for different fates become asymmetric, not just in morphology and developmental potential but also in cell-cycle timing. A recent study has now shown that differential cell-cycle timing in the first cell divisions of the Caenorhabditis elegans embryo is in part controlled by a DNA replication checkpoint.
Schumacher
Björn
B
MPI for Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, D-82152 Martinsried, Germany.
Alpi
Arno
A
Garter
Anton
A
D000818:Animals; D064007:Ataxia Telangiectasia Mutated Proteins; D017173:Caenorhabditis elegans / Q000196:embryology*; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D008954:Models, Biological; D010770:Phosphotransferases / Q000502:physiology; D018809:Proliferating Cell Nuclear Antigen / Q000502:physiology; D015398:Signal Transduction; D013997:Time Factors
D029742:Caenorhabditis elegans Proteins; D018809:Proliferating Cell Nuclear Antigen; C576885:Atl-1 protein, C elegans; D010770:Phosphotransferases; D064007:Ataxia Telangiectasia Mutated Proteins