title: Synthesis of a novel crown ether derived from chiro-inositol and its catalytic activity on the asymmetric Michael addition.
abstract: A novel 18-membered chiral crown ether was prepared in four steps starting from L-quebrachitol, a chiro-inositol, and its catalytic activity in the Michael addition reaction of glycine imine with several Michael acceptors was studied.
authors.affiliation: Department of Chemistry, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo 171-8588, Japan. takahiko.akiyama@gakushuin.ac.jp
authors.forename: Takahiko
authors.initials: T
authors.lastname: Akiyama
authors.forename: Mikiko
authors.initials: M
authors.lastname: Hara
authors.forename: Kohei
authors.initials: K
authors.lastname: Fuchibe
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yamaguchi
mesh_terms: D002384:Catalysis; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000378:metabolism; D007294:Inositol / Q000138:chemical synthesis* / Q000378:metabolism; D015394:Molecular Structure; D009904:Optical Rotation
chemical_list: D004988:Ethers, Cyclic; D007294:Inositol