The role of mitochondria in the life of the nematode, Caenorhabditis elegans.
Mitochondria are essential organelles involved in energy metabolism via oxidative phosphorylation. They play a vital role in diverse biological processes such as aging and apoptosis. In humans, defects in the mitochondrial respiratory chain (MRC) are responsible for or associated with a bewildering variety of diseases. The nematode Caenorhabditis elegans is a simple animal and a powerful genetic and developmental model system. In this review, we discuss how the nematode model system has contributed to our understanding of mitochondrial dynamics, of the genetics and inheritance of the mitochondrial genome, and of the consequences of nuclear and mitochondrial DNA (mtDNA) mutations. Mitochondrial respiration is vital to energy metabolism but also to other aspects of multicellular life such as aging and development. We anticipate that further significant contributions to our understanding of mitochondrial function in animal biology are forthcoming with the C. elegans model system.
Tsang
William Y
WY
Canadian Institutes of Health Research Group in Membrane Protein Research, Department of Biochemistry, University of Alberta, 474 Medical Sciences Bldg., Edmonton, Alberta, Canada T6G 2H7.
Lemire
Bernard D
BD
D000375:Aging / Q000378:metabolism / Q000502:physiology; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D004272:DNA, Mitochondrial / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D017238:Genes, Helminth; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008954:Models, Biological; D009154:Mutation; D010085:Oxidative Phosphorylation
D004272:DNA, Mitochondrial; D015801:Helminth Proteins