title: Systemic capillary leak syndrome resulting from gemcitabine treatment in renal cell carcinoma: a case report.
abstract: In a few cases, gemcitabine (GCB) has been shown to result in systemic capillary leak syndrome (SCLS) in the treatment of non-small cell lung, pancreatic, and ovarian carcinomas. SCLS is a life-threatening condition characterized by increased capillary permeability resulting in manifest pulmonary and peripheral edema. Usually SCLS responds successfully to corticosteroid therapy and diuretics. We present a case where GCB treatment likely resulted in SCLS in a male patient with metastatic renal cell carcinoma (RCC) in the absence of predisposing cardiac, pleural, or pulmonary disease.
authors.affiliation: Department of Oncology, Kuopio University Hospital, Kuopio, Finland. Kalevi.Pulkkanen@uku.fi
authors.forename: K
authors.initials: K
authors.lastname: Pulkkanen
authors.forename: V
authors.initials: V
authors.lastname: Kataja
authors.forename: R
authors.initials: R
authors.lastname: Johansson
mesh_terms: D001707:Biopsy, Needle; D019559:Capillary Leak Syndrome / Q000139:chemically induced* / Q000503:physiopathology; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009392:Nephrectomy / Q000379:methods; D011654:Pulmonary Edema / Q000139:chemically induced / Q000503:physiopathology; D018570:Risk Assessment; D012720:Severity of Illness Index; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D000093542:Gemcitabine