HLA class II genotypic frequencies in atopic asthma: association of DRB1*01-DQB1*0501 genotype with Artemisia vulgaris allergic asthma.
Different human leukocyte antigen (HLA) class II alleles have been associated with the development of atopic asthma. To determine whether HLA class II alleles are associated with atopic asthma in a population from southeast Spain (Murcia region), 213 atopic asthmatic patients and 150 controls were selected for HLA typing. Significant association of the DRB1*01 and DQB1*0501 alleles was found in Artemisia vulgaris allergic patients (p(c) = 0.00052 and p(c) = 0.00023, respectively). No significant correlation was found in other atopic patients allergic to pollens (Phleum pratense, Olea europaea, and Salsola kali), house dust mites (Dermatophagoides pteronyssinus, D. farinae), molds (Alternaria alternata, Cladosporium herbarum), or animal danders (dog, cat). The results reveal that the DRB1*01-DQB1*0501 genotype is strongly associated with a positive response to Artemisia vulgaris in the population studied.
Torío
Alberto
A
Immunology Service, University Hospital "Virgen de la Arrixaca", Murcia, Spain. altorio@um.es
Sánchez-Guerrero
Immaculada
I
Muro
Manuel
M
Villar
Luisa María
LM
Minguela
Alfredo
A
Marín
Luis
L
Moya-Quiles
Maria Rosa
MR
Montes-Ares
Olga
O
Pagán
Juan
J
Alvarez-López
María Rocío
MR
D000483:Alleles; D000485:Allergens / Q000276:immunology*; D019306:Artemisia / Q000276:immunology*; D001249:Asthma / Q000097:blood / Q000235:genetics / Q000276:immunology*; D005787:Gene Frequency; D005802:Genes, MHC Class II; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D012882:Skin Tests; D013030:Spain
D000485:Allergens; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D007073:Immunoglobulin E