A case of leukemia of the appendix presenting as acute appendicitis.
A 71-year-old man was admitted to our hospital because of right lower abdominal pain. He was suspected of having acute appendicitis and soon after admission, appendectomy was performed. Macroscopically, the appendix was greatly swollen and reddened, but had no abscess. Microscopically, polymorphonuclear leukocytes were not found, but diffuse infiltration of atypical cells was observed. Examination of a bone marrow aspirate revealed 74% blasts that were peroxidase stain positive. We diagnosed acute myelogenous leukemia (FAB classification, M2). He received induction chemotherapy, but died 49 days after admission. Leukemic cell infiltration of the appendix is rare and acute appendicitis as the initial manifestation of leukemia is even rarer.
Toubai
Tomomi
T
Department of Hematology, Sapporo Hokuyu Hospital, Japan. ttoubai@hkg.odn.ne.jp
Kondo
Yoko
Y
Ogawa
Takahumi
T
Imai
Akitoshi
A
Kobayashi
Naoki
N
Ogasawara
Masahiro
M
Kiyama
Yoshio
Y
Higa
Toshio
T
Sato
Keisuke
K
Miyokawa
Noriyuki
N
Tanaka
Junji
J
Imamura
Masahiro
M
Kasai
Masaharu
M
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001062:Appendectomy; D001064:Appendicitis / Q000209:etiology* / Q000601:surgery; D001065:Appendix / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D003561:Cytarabine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D003630:Daunorubicin / Q000008:administration & dosage; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D017254:Leukemic Infiltration / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage; D023981:Sarcoma, Myeloid / Q000150:complications* / Q000175:diagnosis / Q000601:surgery
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D003561:Cytarabine; C015019:enocitabine; D015122:Mercaptopurine; D015255:Idarubicin; D003630:Daunorubicin