Therapeutic hypothermia for acute stroke.
Experimental evidence and clinical experience show that hypothermia protects the brain from damage during ischaemia. There is a growing hope that the prevention of fever in stroke will improve outcome and that hypothermia may be a therapeutic option for the treatment of stroke. Body temperature is directly related to stroke severity and outcome, and fever after stroke is associated with substantial increases in morbidity and mortality. Normalisation of temperature in acute stroke by antipyretics is generally recommended, although there is no direct evidence to support this treatment. Despite its obvious therapeutic potential, hypothermia as a form of neuroprotection for stroke has been investigated in only a few very small studies. Therapeutic hypothermia is feasible in acute stroke but owing to serious side-effects--such as hypotension, cardiac arrhythmia, and pneumonia--it is still thought of as experimental, and evidence of efficacy from clinical trials is needed.
Olsen
Tom Skyhøj
TS
Stroke Unit, Hvidovre University Hospital, DK-2650, Hvidovre, Denmark. tso@dadlnet.dk <tso@dadlnet.dk>
Weber
Uno Jakob
UJ
Kammersgaard
Lars Peter
LP
D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology; D001930:Brain Injuries / Q000628:therapy; D002545:Brain Ischemia / Q000628:therapy; D002986:Clinical Trials as Topic; D006323:Heart Arrest / Q000628:therapy; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods; D020521:Stroke / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*
D018712:Analgesics, Non-Narcotic