title: Vesnarinone: a differentiation-inducing anti-cancer drug.
abstract: Vesnarinone has been shown to be a unique anti-proliferating, differentiation-inducing and apoptosis inducing drug against several human malignancies, including leukemia and several solid tumors. Furthermore, vesnarinone potentiates the effect of conventional cytotoxic chemotherapy or radiation therapy. Combination of differentiation-inducing therapy by vesnarinone with conventional chemotherapy or radiation therapy might be second- or third-line therapy in patients with advanced cancer. Analysis of the molecular mechanisms of the tumor differentiation therapy by vesnarinone might provide selective and targeted molecules for novel tumor dormancy therapy.
authors.affiliation: Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan. h-kawama@dokkyomed.ac.jp
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kawamata
authors.forename: Fumie
authors.initials: F
authors.lastname: Omotehara
authors.forename: Koh-ichi
authors.initials: K
authors.lastname: Nakashiro
authors.forename: Daisuke
authors.initials: D
authors.lastname: Uchida
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hino
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujimori
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D011719:Pyrazines; D011804:Quinolines / Q000737:chemistry / Q000627:therapeutic use*; D012097:Repressor Proteins / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000970:Antineoplastic Agents; D011719:Pyrazines; D011804:Quinolines; D012097:Repressor Proteins; C099726:TSC22D1 protein, human; C490983:Tgfb1i4 protein, mouse; C041667:vesnarinone