title: Characteristics of 11 neonates with atrial septal defects detected by heart murmurs.
abstract: The aim of this prospective study was to investigate, using echocardiography, the relationship between heart murmurs found in the neonatal period and atrial septal defect (ASD). Heart murmurs were detected in 115 of 5124 term neonates within 1 month after birth. The babies were followed by echocardiographic examination with attention to the atrial septal area. Heart murmurs of 11 term neonates (9.6%) were associated with interatrial shunts consistent with ASD. The defect closed spontaneously in 7 out of the 11 neonates by 18 months of age. Two neonates showed evidence of right ventricular overload from early infancy. This study showed that nearly 1 neonate in 10 with a heart murmur up to 1 month after birth had an interatrial shunt associated with ASD. We concluded that the absence of a flap sign (valve-like openings of the defects) affects the development of the heart murmur of ASD found in the neonatal period.
authors.affiliation: Department of Paediatrics, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Takami
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kawashima
authors.forename: Akira
authors.initials: A
authors.lastname: Kamikawa
authors.forename: Yukito
authors.initials: Y
authors.lastname: Takei
authors.forename: Tasuku
authors.initials: T
authors.lastname: Miyajima
authors.forename: Akinori
authors.initials: A
authors.lastname: Hoshika
mesh_terms: D006337:Heart Murmurs / Q000209:etiology*; D006344:Heart Septal Defects, Atrial / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D007231:Infant, Newborn; D011446:Prospective Studies; D012075:Remission, Spontaneous; D014463:Ultrasonography