title: 17 Beta-estradiol attenuates development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice.
abstract: OBJECTIVE
  Angiotensin II (Ang II) promotes vascular inflammation, accelerates atherosclerosis, and induces abdominal aortic aneurysm (AAA). These changes were associated with activation of nuclear factor (NF)-kappaB-mediated induction of proinflammatory genes. The incidence of AAA in this model was higher in male than in female mice, and the vascular effects of estrogen may be associated with anti-inflammatory actions. The present study was undertaken to test the hypothesis that estrogen can attenuate Ang II-induced AAA in apolipoprotein E-deficient mice via its anti-inflammatory mechanism.
  
  
  RESULTS
  Infusion of Ang II (1.44 mg/kg per d for 1 month) induced AAA in 90% of the animals (n=20) with an expansion of the suprarenal aorta (diameter 1.9+/-0.14 mm versus <1 mm in normal mice). In mice treated with 17beta-estradiol (E2, 0.25-mg subcutaneous pellets), Ang II induced AAA only in 42% of the animals (n=19) with a significant reduction of average diameters of the suprarenal aorta (1.5+/-0.14 mm). E2 also decreased the expressions of intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, E-selectin, monocyte chemotactic protein-1, and macrophage-colony stimulating factor in the aorta.
  
  
  CONCLUSIONS
  These data suggest that attenuation of AAA by E2 is associated with inhibition of proinflammatory gene expression.
authors.affiliation: Department of Pharmacology, Berlex Biosciences, Richmond, CA 94806, USA.
authors.forename: Baby
authors.initials: B
authors.lastname: Martin-McNulty
authors.forename: Doris M
authors.initials: DM
authors.lastname: Tham
authors.forename: Valdeci
authors.initials: V
authors.lastname: da Cunha
authors.forename: Jerrick J
authors.initials: JJ
authors.lastname: Ho
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Wilson
authors.forename: John C
authors.initials: JC
authors.lastname: Rutledge
authors.forename: Gary G
authors.initials: GG
authors.lastname: Deng
authors.forename: Ronald
authors.initials: R
authors.lastname: Vergona
authors.forename: Mark E
authors.initials: ME
authors.lastname: Sullivan
authors.forename: Yi-Xin
authors.initials: YX
authors.lastname: Wang
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control*; D001057:Apolipoproteins E / Q000172:deficiency*; D004195:Disease Models, Animal; D004958:Estradiol / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D007249:Inflammation / Q000209:etiology / Q000517:prevention & control; D008297:Male; D051379:Mice
chemical_list: D001057:Apolipoproteins E; D000804:Angiotensin II; D004958:Estradiol