title: Clear cell ependymoma with a lipidized component that developed in the thoracic spinal cord.
abstract: The authors report a case of clear cell ependymoma with a lipidized component that developed in the thoracic spinal cord. A 59-year-old man was admitted to the hospital with an itchy pain in the left forearm to the left anterior and lateral chest for the past three years. Neurological findings on admission included dissociated sensory disturbance below the C8 level and increased deep tendon reflex in both lower extremities. An MRI scan of the spinal cord revealed an intramedullary tumor with a longer diameter of 3.5 cm at the T3-T4 level and a distended syrinx at the T2-T3 level. Surgery was performed after T1-T5 laminectomy. The gray, soft and well demarcated tumor was removed subtotally. Light microscopy revealed a portion where clear cells proliferated and a portion where foamy cells proliferated. In some tissue, there were a very few nuclear areas suggestive of a perivascular pseudorosette. Neither nuclear division nor necrosis was observed. Immunohistochemically, the tumor cells were positive for glial fibrillary acidic protein (GFAP), epithelial membrane antigen (EMA), vimentin, and negative for cytokeratin, synaptophysin. The MIB-1 staining index was 0.25%. Based on these findings, diagnosis of clear cell ependymoma with a lipidized component was made.
authors.affiliation: Department of Neurosurgery, Higashiosaka City General Hospital, 3-4-5 Nishiiwata-cho, Higashiosaka 578-8588, Japan. y-kim@oph.gr.jp
authors.forename: Yeong-Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tsunoda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Kazunori
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Tamai
authors.forename: Michiko
authors.initials: M
authors.lastname: Yamauchi
mesh_terms: D004806:Ependymoma / Q000473:pathology*; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D008055:Lipids; D008297:Male; D008875:Middle Aged; D013120:Spinal Cord Neoplasms / Q000473:pathology*; D013904:Thoracic Vertebrae
chemical_list: D008055:Lipids