[The knack of treatment for obese patients with hypertension and diabetes mellitus: combined the newest tailor-made diet therapy with the usual stress-management therapy].
The 5-10% body weight loss often leads to amelioration or cure of hypertension and diabetes mellitus in obese patients. But, the effect of diet therapy on obese patients differs in each individual because of the differences in energy expenditure, such as the resting metabolic rate (RMR). We have recently reported that obese Japanese with the missense mutation (Trp64Arg) of the beta 3-adrenergic receptor (beta 3-AR) gene and/or the uncoupling protein 1 (UCP1) gene mutation (A-3826G) have difficulties in weight loss by the reducing RMR, while Japanese with beta 2-AR gene mutation (Arg16Gly) have an under-weight condition through increased RMR. Here I introduce the importance of tailor-made diet therapy to improve obesity based on analysis of gene polymorphisms and in order to maintain this tailor-made diet therapy, I emphasize that the stress-management therapy should be needed to remove mental problems which caused obesity.
Yoshida
Toshihide
T
Department of Endocrinology, Diabetes and Metabolism, Kyoto Prefectural University of Medicine.
D002352:Carrier Proteins / Q000235:genetics; D048909:Diabetes Complications; D004734:Energy Metabolism / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007333:Insulin Resistance; D007473:Ion Channels; D008565:Membrane Proteins / Q000235:genetics; D024101:Mitochondrial Proteins; D020125:Mutation, Missense; D009765:Obesity / Q000150:complications / Q000178:diet therapy* / Q000235:genetics*; D011110:Polymorphism, Genetic; D011613:Psychotherapy; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics; D013315:Stress, Psychological / Q000628:therapy; D000071256:Uncoupling Protein 1
D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D018343:Receptors, Adrenergic, beta-2; D022702:Receptors, Adrenergic, beta-3; C000604371:UCP1 protein, human; D000071256:Uncoupling Protein 1