Structural analogues of the bimetallic reaction center in acetyl CoA synthase: a Ni--Ni model with bound CO.
Models for the active site of the acetyl CoA synthase (ACS) were synthesized by attachment of Cu+ and Ni(0) to nickel diaminodithiolate (S2N2) and diamidodithiolate (S2N2') complexes. The Ni-Ni species form stable CO adducts, i.e., [{(CO)2Ni}{NiS2N2'}]2-, whereas the Cu-NiS2N2 and Cu-NiS2N2' models do not. These results provide supporting evidence for a biological role for reduced nickel in ACS.
Linck
Rachel C
RC
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Spahn
Cameron W
CW
Rauchfuss
Thomas B
TB
Wilson
Scott R
SR
D000106:Acetate-CoA Ligase / Q000737:chemistry*; D040761:Biomimetic Materials / Q000737:chemistry; D002248:Carbon Monoxide / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*
D009942:Organometallic Compounds; D009532:Nickel; D002248:Carbon Monoxide; D000106:Acetate-CoA Ligase