title: Differential induction of interleukin-I beta mRNA in the brain parenchyma of Lewis and Fischer rats after peripheral injection of lipopolysaccharides.
abstract: The expression of interleukin-1 beta (IL-1beta) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 h after peripheral administration of lipopolysaccharide (LPS) or saline. No differences between strains were observed in the circumventricular organs (CVOs) and choroid plexus. At 12 h after LPS administration, increased IL-1beta mRNA expression was detected in the hypothalamus of LEW/N rats. In contrast, increased IL-1beta mRNA expression was detected in the cerebral cortex of F344/N rats. These data show region-specific differences of IL-1beta mRNA expression in the brain of these rat strains that differ in their susceptibility to inflammation.
authors.affiliation: Section of Neuroendocrine Immunology and Behavior, National Institute of Mental Health, NIH, DHHS, 36 Convent Drive MSC 4020, Building 36, Room 1A23, Bethesda, MD 20892-4020, USA.
authors.forename: Leonardo H
authors.initials: LH
authors.lastname: Tonelli
authors.forename: Shigeru
authors.initials: S
authors.lastname: Maeda
authors.forename: Kimberly L
authors.initials: KL
authors.lastname: Rapp
authors.forename: Esther M
authors.initials: EM
authors.lastname: Sternberg
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000235:genetics* / Q000276:immunology; D002540:Cerebral Cortex / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D002552:Cerebral Ventricles; D002831:Choroid Plexus / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D003342:Corpus Striatum / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease; D007031:Hypothalamus / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D007113:Immunity, Innate / Q000235:genetics; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D007274:Injections, Intraperitoneal; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000235:genetics; D008070:Lipopolysaccharides / Q000008:administration & dosage*; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew
chemical_list: D007375:Interleukin-1; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D003345:Corticosterone