Versatility of aminoglycosides and prospects for their future.
Aminoglycoside antibiotics have had a major impact on our ability to treat bacterial infections for the past half century. Whereas the interest in these versatile antibiotics continues to be high, their clinical utility has been compromised by widespread instances of resistance. The multitude of mechanisms of resistance is disconcerting but also illuminates how nature can manifest resistance when bacteria are confronted by antibiotics. This article reviews the most recent knowledge about the mechanisms of aminoglycoside action and the mechanisms of resistance to these antibiotics.
Vakulenko
Sergei B
SB
Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.
Mobashery
Shahriar
S
D000123:Acetyltransferases / Q000378:metabolism; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D009713:Nucleotidyltransferases / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000123:Acetyltransferases; C443113:aminoglycoside 2'-N-acetyltransferase; D017853:Phosphotransferases (Alcohol Group Acceptor); C048564:aminoglycoside 2''-phosphotransferase; D009713:Nucleotidyltransferases; C020565:gentamicin 2''-nucleotidyltransferase