[BK virus-associated nephropathy].
BK virus was first detected more than 30 years ago, however its role long time was not exactly defined. The virus is usually acquired in childhood; seroprevalence rate in adults appears to be 60-80%. In most cases the infection is asymptomatic. After renal transplantation it may manifest as so-called BK virus-associated nephropathy by gradual decrease of allograft function or signs of acute rejection. There is no effective therapy of BK virus-associated nephropathy to date. Treatment with low-dose cidofovir is under investigation.
Kaltenis
Petras
P
Centre for Pediatrics, Clinic of Children's Diseases, Vilnius University, Santariskiu 4, 2021 Vilnius, Lithuania. petras.kaltenis@mf.vu.lt
D000328:Adult; D000367:Age Factors; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001739:BK Virus / Q000302:isolation & purification; D002648:Child; D000077404:Cidofovir; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006084:Graft Rejection / Q000209:etiology; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000821:virology; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D027601:Polyomavirus Infections / Q000150:complications* / Q000188:drug therapy; D011247:Pregnancy; D013997:Time Factors; D014412:Tumor Virus Infections / Q000150:complications* / Q000188:drug therapy
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir