title: Antifouling blood purification membrane composed of cellulose acetate and phospholipid polymer.
abstract: The ideal surface of an artificial blood purification membrane needs hemocompatibility and durability of high performance; it should not adsorb any proteins or cells but should still have high permeability in the desired range of solute size. To improve the anti-fouling property of cellulose acetate (CA) membranes, a CA membrane blended with poly(2-methacryloyloxyethyl phosphorylcholine (MPC)-co-n-butyl methacrylate (BMA)) (PMB30) was designed as a blood purification membrane. The polymer solutions for preparing the membrane were prepared using a solvent mixture composed of N, N-dimethylformamide, acetone, 2-propanol or water. The CA and CA/PMB30 blend membranes with an asymmetric and porous structure were prepared by a phase inversion process. The characteristics of the CA/PMB30 blend membrane, such as structural properties, mechanical properties, and solute permeability were examined with attention to changes in the preparation conditions of the membrane. The CA/PMB30 blend membrane had good water and solute permeability and a sharp molecular weight cut-off property. Moreover, the amount of proteins adsorbed on the CA/PMB30 blend membrane surface was less than that of the original CA membrane and a conventional polysulfone membrane. Adhesion and activation of platelets on the CA/PMB30 blend membrane were reduced compared with that on a CA membrane. In addition, the CA/PMB30 blend membrane showed good permselectivity and an antifouling property during a long time ultrafiltration experiment with protein solutions.
authors.affiliation: Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Ye
authors.forename: Junji
authors.initials: J
authors.lastname: Watanabe
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ishihara
mesh_terms: D019840:2-Propanol / Q000737:chemistry; D000096:Acetone / Q000737:chemistry; D000327:Adsorption; D000388:Air; D001774:Blood Chemical Analysis; D002448:Cell Adhesion; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry*; D002624:Chemistry, Clinical / Q000379:methods*; D005898:Glass; D006801:Humans; D008567:Membranes, Artificial; D008689:Methacrylates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D010743:Phospholipids / Q000737:chemistry*; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry*; D010949:Plasma / Q000737:chemistry; D010973:Platelet Adhesiveness; D011108:Polymers / Q000737:chemistry*; D011312:Pressure; D011506:Proteins / Q000737:chemistry; D012997:Solvents / Q000494:pharmacology; D013718:Tensile Strength; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D008567:Membranes, Artificial; D008689:Methacrylates; D010743:Phospholipids; D011108:Polymers; D011506:Proteins; D012997:Solvents; D014867:Water; D010767:Phosphorylcholine; C079200:poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate); D000096:Acetone; C005062:acetylcellulose; D002482:Cellulose; D019840:2-Propanol