[Correction of immunodeficiency status caused by herbicide 2,4-D in experiment].
A possibility to correct the immunodeficiency state, caused by herbicide 2.4-D (20 mg/kg of weight daily during 5 days), by using immunomodulators Levamisole (perorally), Tactivinum (hypodermically) and Spleninum (hepodermically) in reactions Graft-versus-Host (GH), Antibody-Forming Cells (AFG) and phagocytic activity of peritoneal macrophages in vivo and in vitro etc, was studied in experiments with 360 mice of lines CBA and F1 (CBAxC57B1/6) weighing 18 to 22 g. It was established that Levamisole (2.5 mg/kg per body weight, for 1 to 3 days) and Tactivinum (0.2 mkg/mouse, for 1 to 3 days) had an immunocorrecting effect in poisoning by 2.4-D. Spleninum (10 mcl/mouse) corrected mainly the humoral chain in the immune response with the AFG recovery to the level observed in intact animals (controls). The data on the influence produced by the immunomodulators on the phagocytic activity in vitro correlated with such data obtained in vivo.
Zhamsaranova
S D
SD
Lebedeva
S N
SN
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006540:Herbicides / Q000009:adverse effects*; D007279:Injections, Subcutaneous; D007978:Levamisole / Q000008:administration & dosage / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D010586:Phagocytes / Q000187:drug effects*; D013946:Thymopoietins / Q000008:administration & dosage / Q000494:pharmacology*; D013949:Thymus Extracts / Q000008:administration & dosage / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D006540:Herbicides; D010455:Peptides; D013946:Thymopoietins; D013949:Thymus Extracts; D007978:Levamisole; C032841:thymopoietin III; C036191:T-activin