New strategy for comprehensive analysis of polybrominated diphenyl ethers, polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls by gas chromatography coupled with mass spectrometry.
A strategy for determination of polybrominated diphenyl ethers, polychlorinated dibenzodioxins, polychlorinated dibenzofurans and polychlorinated biphenyls on fatty matrices has been established. After extraction, the proposed method allows the purification and the fractionation of all target groups of compounds in a simple multi-step automated clean-up. Furthermore, their subsequent analysis is carried out using a single benchtop mass spectrometer, in four separate injections. Required sensitivity considering levels found in the environment is attained using electron impact ionisation followed by tandem in time mass spectrometry. The whole method has been evaluated on standard solution and quality control samples consisting of fortified beef fat. Sensitivity, selectivity, accuracy and repeatability were tested with satisfactory results.
Pirard
Catherine
C
Mass Spectrometry Laboratory, University of Liege, Allee de la Chimie 3, Bat. B6c Sart-Tilman, B-4000 Liege, Belgium. catherine.pirard@ulg.ac.be
De Pauw
Edwin
E
Focant
Jean-François
JF
D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006842:Hydrocarbons, Brominated / Q000032:analysis*; D006843:Hydrocarbons, Chlorinated / Q000032:analysis*; D012680:Sensitivity and Specificity
D006842:Hydrocarbons, Brominated; D006843:Hydrocarbons, Chlorinated