title: Detection of spike and wave discharges in the cortical EEG of genetic absence epilepsy rats from Strasbourg.
abstract: Genetic absence epilepsy rats from Strasbourg (GAERS) are a strain of Wistar rats in which all animals present spontaneous occurrence of spike and wave discharges (SWD) in the cortical electroencephalogram (EEG). In this paper, we present a method for the detection of SWD, based on the key observation that SWD are quasi-periodic signals. A spectral-comb based analysis method is used to extract the fundamental frequency and the percentage of energy explained by the harmonic spectral components is subsequently used as a detection parameter. It is shown that a maximum sensitivity and specificity of up to 96 per cent can be achieved. We also compared the performance of this method with the methods presented in the literature and conclude that the surplus value of the novel detection method lies in the higher specificity that can be obtained in the analysis of long-term EEG fragments, which are contaminated by artefacts and contain large portions of slow-wave sleep.
authors.affiliation: Ghent University, Department of Electronics and Information Systems, Sint-Pietersnieuwstraat 41, 9000 Ghent, Belgium. peter.vanhese@ugent.be
authors.forename: P
authors.initials: P
authors.lastname: Van Hese
authors.forename: J P
authors.initials: JP
authors.lastname: Martens
authors.forename: P
authors.initials: P
authors.lastname: Boon
authors.forename: S
authors.initials: S
authors.lastname: Dedeurwaerdere
authors.forename: I
authors.initials: I
authors.lastname: Lemahieu
authors.forename: R
authors.initials: R
authors.lastname: Van de Walle
mesh_terms: D000200:Action Potentials; D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography / Q000706:statistics & numerical data; D004832:Epilepsy, Absence / Q000235:genetics / Q000503:physiopathology*; D008959:Models, Neurological; D012372:ROC Curve; D051381:Rats; D017208:Rats, Wistar; D012680:Sensitivity and Specificity; D012890:Sleep / Q000502:physiology