title: Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone.
abstract: Pneumolysin, a virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities, occurs at concentrations from 0.85 to 180 ng/ml in cerebrospinal fluid (CSF) of meningitis patients. In pneumococcal cultures and in a rabbit meningitis model, the concentrations of pneumolysin in supernatant and CSF were lower after addition of nonbacteriolytic bactericidal antibiotics (rifampin and clindamycin) than after incubation with ceftriaxone.
authors.affiliation: Department of Neurology, University of Göttingen, Göttingen, Germany.
authors.forename: Annette
authors.initials: A
authors.lastname: Spreer
authors.forename: Holger
authors.initials: H
authors.lastname: Kerstan
authors.forename: Tobias
authors.initials: T
authors.lastname: Böttcher
authors.forename: Joachim
authors.initials: J
authors.lastname: Gerber
authors.forename: Alexander
authors.initials: A
authors.lastname: Siemer
authors.forename: Gregor
authors.initials: G
authors.lastname: Zysk
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Mitchell
authors.forename: Helmut
authors.initials: H
authors.lastname: Eiffert
authors.forename: Roland
authors.initials: R
authors.lastname: Nau
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins; D002443:Ceftriaxone / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D002675:Child, Preschool; D015169:Colony Count, Microbial; D003470:Culture Media; D003864:Depression, Chemical; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D008297:Male; D008586:Meningitis, Pneumococcal / Q000134:cerebrospinal fluid / Q000378:metabolism* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011817:Rabbits; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000378:metabolism*; D013301:Streptolysins / Q000134:cerebrospinal fluid / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002511:Cephalosporins; D003470:Culture Media; D013301:Streptolysins; C032290:plY protein, Streptococcus pneumoniae; D002443:Ceftriaxone