Behavior of plasma hemoglobin in an experimental model of occlusive mesenteric ischemia.
The difficulties in establishing the diagnosis of mesenteric ischemia are responsible for the high mortality rate that is associated with this clinical condition. We studied the behavior of plasma hemoglobin in an experimental model of occlusive mesenteric ischemia in mice. Our results showed a clear relationship between the duration of ischemia and plasma hemoglobin levels. With regard to the time frames studied (3 hours, 6 hours, 12 hours, and 24 hours), comparison with control groups produced calculated P values of less than 0.01 for all time frames with the exception of the 3-hour group. This test may have the potential to aid in the diagnosis of mesenteric ischemia as well as the follow-up of its course after various therapeutic approaches.
Constant-Neto
Manoel
M
Instituto de Pesquisas Biomédicas da PUCRS, Hospital São Lucas da Pontifícia, Universidade Católica do RS, Porto Alegre, Brasil. mconstant@via-rs.net
Hartmann
Marcelo Junges
MJ
Goulart
Aline Hamilton
AH
Machado
Denise Cantarelli
DC
Constant
Samuel Antônio Raffo
SA
Cuervo
Carlos
C
D000818:Animals; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D007511:Ischemia / Q000097:blood* / Q000175:diagnosis; D008641:Mesenteric Vascular Occlusion / Q000097:blood*; D008643:Mesentery / Q000098:blood supply*; D051379:Mice; D012680:Sensitivity and Specificity; D013997:Time Factors
D006454:Hemoglobins