Lateralized cognitive processes and lateralized task control in the human brain.
The principles underlying human hemispheric specialization are poorly understood. We used functional magnetic resonance imaging of letter and visuospatial decision tasks with identical word stimuli to address two unresolved problems. First, hemispheric specialization depended on the nature of the task rather than on the nature of the stimulus. Second, analysis of frontal candidate regions for cognitive control showed increased coupling between left anterior cingulate cortex (ACC) and left inferior frontal gyrus during letter decisions, whereas right ACC showed enhanced coupling with right parietal areas during visuospatial decisions. Cognitive control is thus localized in the same hemisphere as task execution.
Stephan
Klaas E
KE
Institute of Medicine (IME), Research Centre Jülich, 52425 Jülich, Germany.
Marshall
John C
JC
Friston
Karl J
KJ
Rowe
James B
JB
Ritzl
Afra
A
Zilles
Karl
K
Fink
Gereon R
GR
D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D003071:Cognition; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000502:physiology; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D010296:Parietal Lobe / Q000502:physiology; D017397:Prefrontal Cortex / Q000502:physiology; D013028:Space Perception; D014796:Visual Perception