Antiadhesive peptides as the inhibitors of Mycobacterium kansasii phagocytosis.
Initial entry of Mycobacteria into the cells depends upon the formation of a molecular complex between Antigen 85 (Ag85), located on the bacterial cell wall, and serum protein-fibronectin (FN) [Nat. Struct. Biol. 7 (2000) 141; Nat. Struct. Biol. 7 (2000) 94]. Therefore, a way of preventing a Mycobacteria invasion could be to inhibit the interaction between fibronectin and leucocyte cellular receptors of the integrin type. We found that some antiadhesive peptides (such as RGDVY and GRGD), derived of fibronectin and human leucocyte antigen DQ (HLA-DQ) sequences, are in fact very potent inhibitors of Mycobacterium kansasii phagocytosis. This observation may open new prospects in the search for tuberculosis therapy.
Siemion
Ignacy Z
IZ
Faculty of Chemistry, Wrocław University, Poland. siemon@wchuwr.chem.uni.wroc.pl
Wieczorek
Zbigniew
Z
D001422:Bacterial Adhesion; D002448:Cell Adhesion; D002473:Cell Wall / Q000737:chemistry; D005353:Fibronectins / Q000378:metabolism; D016023:Integrins / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D019909:Mycobacterium kansasii / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry*; D010587:Phagocytosis / Q000187:drug effects; D013696:Temperature
D005353:Fibronectins; D016023:Integrins; D010455:Peptides