title: FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder.
abstract: Disruption of FOXP2, a gene encoding a forkhead-domain transcription factor, causes a severe developmental disorder of verbal communication, involving profound articulation deficits, accompanied by linguistic and grammatical impairments. Investigation of the neural basis of this disorder has been limited previously to neuroimaging of affected children and adults. The discovery of the gene responsible, FOXP2, offers a unique opportunity to explore the relevant neural mechanisms from a molecular perspective. In the present study, we have determined the detailed spatial and temporal expression pattern of FOXP2 mRNA in the developing brain of mouse and human. We find expression in several structures including the cortical plate, basal ganglia, thalamus, inferior olives and cerebellum. These data support a role for FOXP2 in the development of corticostriatal and olivocerebellar circuits involved in motor control. We find intriguing concordance between regions of early expression and later sites of pathology suggested by neuroimaging. Moreover, the homologous pattern of FOXP2/Foxp2 expression in human and mouse argues for a role for this gene in development of motor-related circuits throughout mammalian species. Overall, this study provides support for the hypothesis that impairments in sequencing of movement and procedural learning might be central to the FOXP2-related speech and language disorder.
authors.affiliation: Neural Development Unit, Institute of Child Health, University College London, UK.
authors.forename: Cecilia S L
authors.initials: CS
authors.lastname: Lai
authors.forename: Dianne
authors.initials: D
authors.lastname: Gerrelli
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Monaco
authors.forename: Simon E
authors.initials: SE
authors.lastname: Fisher
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Copp
mesh_terms: D000328:Adult; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000196:embryology* / Q000254:growth & development / Q000473:pathology; D005314:Embryonic and Fetal Development / Q000235:genetics; D051858:Forkhead Transcription Factors; D015870:Gene Expression; D006801:Humans; D017403:In Situ Hybridization; D007806:Language Disorders / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D009043:Motor Activity / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D012097:Repressor Proteins / Q000096:biosynthesis* / Q000235:genetics; D013064:Speech Disorders / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014157:Transcription Factors
chemical_list: C465448:FOXP2 protein, human; D051858:Forkhead Transcription Factors; C432918:Foxp2 protein, mouse; D012333:RNA, Messenger; D012097:Repressor Proteins; D014157:Transcription Factors