Successful treatment of a high-grade intraepithelial neoplasia with imiquimod, with vulvar pemphigus as a side effect.
Imiquimod modulates the immune response, and is a new approach for treatment of papillomavirus-associated lesions, although it has not been approved for the treatment of intraepithelial neoplasia. We present a case of a patient treated with imiquimod on account of high-grade intraepithelial neoplasia in the vulva and other locations. The posterior biopsies confirm the absence of lesions but show drug-induced pemphigus as a side effect.
Campagne
G
G
Department of Obstetrics and Gynecology, Clínica Bella Médica, Partida Cap Negret 17, 03590 Altea, Spain. ghislaine@ctv.es
Roca
M
M
Martínez
A
A
D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000634:Aminoquinolines / Q000009:adverse effects / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000628:therapy / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000628:therapy* / Q000821:virology; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis / Q000628:therapy* / Q000821:virology; D006801:Humans; D000077271:Imiquimod; D027383:Papillomaviridae / Q000187:drug effects; D030361:Papillomavirus Infections / Q000139:chemically induced; D010392:Pemphigus / Q000139:chemically induced* / Q000821:virology; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000628:therapy / Q000821:virology; D014625:Vaginal Neoplasms / Q000175:diagnosis / Q000628:therapy / Q000821:virology; D014845:Vulvar Diseases / Q000139:chemically induced*; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000628:therapy / Q000821:virology
D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod