title: [Treatment of septic shock with the use of CPFA (associated plasma filtration and adsorption): impact on hemodynamics monitored with PiCCO ].
abstract: BACKGROUND
  Septic shock represents an emerging pathology and sepsis and its complications are the main cause of death in medical and surgical intensive care units. Single-target therapeutic trials failed to demonstrate any benefit, suggesting that the unselective removal of different mediators may be a more appropriate approach.
  
  
  METHODS
  We evaluated a new technique (CPFA) combining a plasma-adsorption (with plasma filter and sorbent cartridge) with a traditional 'slow' extracorporeal treatment on 10 patients, 7 men and 3 women (mean age 53.8+/-16.3), all on mechanical ventilation, with septic shock and multiorgan failure. To identify easily comparable clinical data, the hemodynamic parameters of the patients were monitored with a recently developed, minimally invasive technology, Pulsion PiCCO .
  
  
  RESULTS
  We obtained significant improvement of pre- versus post-treatment mean arterial pressure 77.2+/-12.5 vs. 83.3+/-14.1 mmHg (p<0.0001), cardiac index 4.03+/-0.89 vs. 3.46+/-0.82 L/m2/min (p<0.0001), indexed systemic vascular resistances 1388+/-496 vs. 1753+/-516 dynes x sec/cm5 (p<0.0001), PaO2/FiO2 ratio 204+/-87 vs. 232+/-81 (p<0.0001), and norepinephrine requirements 0.13+/-0.07 vs. 0 y/kg/min after a mean of 5.3+/-2.7 consecutive treatments. The survival at day 28 was 90%. Seven patients were discharged from the intensive care unit after a mean of 37.8+/-24 days (range 10-93).
  
  
  CONCLUSIONS
  Our data suggest a promising role for CPFA in improving hemodynamics and correcting vasoparalysis in septic shock. Moreover, the noninvasive monitoring of hemodynamic parameters with PiCCO could become a useful tool for estimating the effect of treatment and gaining easily comparable data in different patients.
authors.affiliation: UU.OO Nefrologia-Dialisi, Ospedale Torino Nord Emergenza San Giovanni Bosco, Torino.
authors.forename: G
authors.initials: G
authors.lastname: Cesano
authors.forename: S
authors.initials: S
authors.lastname: Livigni
authors.forename: A
authors.initials: A
authors.lastname: Vallero
authors.forename: C
authors.initials: C
authors.lastname: Olivieri
authors.forename: M
authors.initials: M
authors.lastname: Borca
authors.forename: F
authors.initials: F
authors.lastname: Quarello
authors.forename: C
authors.initials: C
authors.lastname: Tetta
authors.forename: M
authors.initials: M
authors.lastname: Formica
mesh_terms: D000327:Adsorption; D003422:Critical Care; D005260:Female; D006439:Hemodynamics; D006440:Hemofiltration; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D012772:Shock, Septic / Q000628:therapy*