title: Treadmill exercise suppresses diabetes-induced increment of neuropeptide Y expression in the hypothalamus of rats.
abstract: Diabetes mellitus is a metabolic disorder with serious sequelae in humans. Hyperphagia is a characteristic symptom of diabetes and is a central nervous system-mediated disorder. Neuropeptide Y (NPY) is a 36-amino-acid peptide and is concentrated in the hypothalamus which is an appetite-regulating area. NPY is known to stimulate appetite and decrease energy expenditure. In the present study, the effect of treadmill exercise on the hypothalamic NPY expression in rats with streptozotocin (STZ)-induced diabetes was investigated via immunohistochemistry. Enhanced NPY expression in the paraventricular nucleus and arcuate nucleus was observed in the STZ-induced diabetic rats. Treadmill exercise suppressed a diabetes-induced increase of NPY expression. The present results suggest the possibility that treadmill exercise inhibits diabetes-induced increment of the desire for food.
authors.affiliation: Kohwang Medical Research Institute, Kyung Hee University, Seoul, South Korea.
authors.forename: Mal Soon
authors.initials: MS
authors.lastname: Shin
authors.forename: Hong
authors.initials: H
authors.lastname: Kim
authors.forename: Hyun Kyung
authors.initials: HK
authors.lastname: Chang
authors.forename: Taeck Hyun
authors.initials: TH
authors.lastname: Lee
authors.forename: Mi Hyeon
authors.initials: MH
authors.lastname: Jang
authors.forename: Min Chul
authors.initials: MC
authors.lastname: Shin
authors.forename: Baek Vin
authors.initials: BV
authors.lastname: Lim
authors.forename: Hee Hyuk
authors.initials: HH
authors.lastname: Lee
authors.forename: Young Pyo
authors.initials: YP
authors.lastname: Kim
authors.forename: Jin Hwan
authors.initials: JH
authors.lastname: Yoon
authors.forename: Il Gyu
authors.initials: IG
authors.lastname: Jeong
authors.forename: Chang Ju
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005080:Exercise Test; D007031:Hypothalamus / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009478:Neuropeptide Y