title: [A clinical analysis of 71 cases of amyloidosis].
abstract: OBJECTIVE
  To comprehend the clinical characteristics and treatment of amyloidosis.
  
  
  METHODS
  The clinical data of 71 patients with amyloidosis, admitted to Peking Union Medical College Hospital from February 1982 to February 2002, were analyzed.
  
  
  RESULTS
  57 of the 71 cases were systemic amyloidosis. Among the 57 cases, 33 were primary systemic amyloidosis, 22 secondary systemic amyloidosis and 2 familial amyloid polyneuropathy.The remaining 14 cases were localized amyloidosis.82% of the patients with systemic amyloidosis showed abnormalities in Doppler echocardiography. The positive rate of biopsy of subcutaneous fat and gingiva was 80.0% and 87.5% respectively. The treatment of systemic amyloidosis was chemotherapy, and that of localized amyloidosis was observation or localized excision. 15 systemic amyloidosis patients died during hospitalization, mainly due to congestive heart failure.
  
  
  CONCLUSIONS
  As treatment and prognosis are different between local and systemic amyloidosis, the distinction between them is very important. Biopsy of abdominal fat and gingival is a useful and safe procedure to identify patients with systemic disease. Doppler echocardiography examination is also helpful for the diagnosis.
authors.affiliation: Department of Hematology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. zypzdx@163.net
authors.forename: Yu-ping
authors.initials: YP
authors.lastname: Zhong
authors.forename: Yong-ji
authors.initials: YJ
authors.lastname: Wu
authors.forename: Jun-ling
authors.initials: JL
authors.lastname: Zhuang
mesh_terms: D000005:Abdomen / Q000473:pathology; D000273:Adipose Tissue / Q000473:pathology; D000686:Amyloidosis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D001707:Biopsy, Needle; D003224:Congo Red; D018618:Echocardiography, Doppler, Color; D005260:Female; D005881:Gingiva / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D003224:Congo Red