Association of the 5-HT2c gene with susceptibility and minimum body mass index in anorexia nervosa.
The association between a non-conservative Cys23Ser in the 5-HT2c gene and anorexia nervosa in females was examined. We used case-controls and family based association analysis in a sample of 118 patients with DSMIV anorexia nervosa, 244 controls and 47 family trios. There was a significant increase in the frequency of the Ser23 allele in the patients by allele (18.8% vs 12.8%; p = 0.026; OR 1.58, 95% CI 1.0-2.4) and genotype (32.2% vs 19.9%; genotype-wise p = 0.027). There was significant correlation between genotype and minimum BMI (r2 = 0.056; p = 0.01), indicating that the Ser23 allele has an effect on severity of illness. We performed TDT analysis using a sub-sample of the cases (58) for whom both parents were available and we found an excess transmission of the Ser23 allele (p = 0.05). Our findings are consistent a role for the Ser23 allele of 5-HT2c in mediating susceptibility to and increasing severity of anorexia nervosa.
Hu
Xun
X
Section of Genetics, Department of Psychological Medicine, Institute of Psychiatry, London, UK.
Giotakis
Orestis
O
Li
Tao
T
Karwautz
Andreas
A
Treasure
Janet
J
Collier
David A
DA
D000483:Alleles; D000856:Anorexia Nervosa / Q000235:genetics*; D015992:Body Mass Index; D016022:Case-Control Studies; D003553:Cystine / Q000235:genetics; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000235:genetics*; D012694:Serine / Q000235:genetics
D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin; D012694:Serine; D003553:Cystine