title: Vesicular cycling mechanisms that control auxin transport polarity.
abstract: The polar transport of auxin controls many important plant growth and developmental processes. The polarity of auxin movement has long been suggested to be mediated by asymmetric distribution of auxin transport proteins, yet, until recently, little was known about the mechanisms that establish protein asymmetry in auxin-transporting cells. Now, a recent paper provides significant insight into the mechanism by which the GNOM protein controls the cycling of an auxin efflux carrier protein, PIN1, between the endosome and the plasma membrane. The dynamic movement of auxin transport proteins between internal compartments and the plasma membrane suggests mechanisms for alterations in auxin transport polarity in response to changing developmental or environmental regulation.
authors.affiliation: Department of Biology, Wake Forest University, Winston-Salem, NC 27109, USA. muday@wfu.edu
authors.forename: Gloria K
authors.initials: GK
authors.lastname: Muday
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Peer
authors.forename: Angus S
authors.initials: AS
authors.lastname: Murphy
mesh_terms: D029681:Arabidopsis Proteins / Q000378:metabolism; D001693:Biological Transport, Active / Q000187:drug effects; D020126:Brefeldin A / Q000494:pharmacology; D002462:Cell Membrane / Q000378:metabolism; D016764:Cell Polarity; D011992:Endosomes / Q000187:drug effects / Q000378:metabolism*; D020662:Guanine Nucleotide Exchange Factors; D007210:Indoleacetic Acids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D026901:Membrane Transport Proteins; D059828:Plant Cells; D010937:Plant Growth Regulators / Q000378:metabolism; D010944:Plants / Q000187:drug effects / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; C088087:GNOM protein, Arabidopsis; D020662:Guanine Nucleotide Exchange Factors; D007210:Indoleacetic Acids; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C116363:PIN1 protein, Arabidopsis; D010937:Plant Growth Regulators; D020126:Brefeldin A