title: Antiviral activity of N-benzoylphenylisoserinates of Lactarius sesquiterpenoid alcohols in vitro.
abstract: Cytotoxic, antiviral, antibacterial and antifungal properties of a new, originally synthesised group of compounds: the N-benzoylphenylisoserinates of sesquiterpenoid alcohols - derivatives of taxol and various sesquiterpenes of Lactarius origin were evaluated in vitro. Among 16 compounds tested, 6 decreased HSV-1 titres. Selectivity indices ranged from 13.9 to 31.7. No activity against RNA viruses (parainfluenza 3, Coxsackie B3, vesicular stomatitis virus, and encephalomyocarditis virus), bacteria: Escherichia coli, Proteus mirabilis, Staphylococcus aureus, Enterococcus faecium and Bacteroides fragilis and fungal strain of Candida albicans was detected.
authors.affiliation: Chair and Department of Medical Microbiology, Medical University of Warsaw, Poland. ewakrawczyk@gazeta.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Krawczyk
authors.forename: Mirosław
authors.initials: M
authors.lastname: Łuczak
authors.forename: Mirosław
authors.initials: M
authors.lastname: Kobus
authors.forename: Dariusz
authors.initials: D
authors.lastname: Bańka
authors.forename: Włodzimierz
authors.initials: W
authors.lastname: Daniewski
mesh_terms: D000363:Agaricales; D000438:Alcohols / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D012694:Serine / Q000031:analogs & derivatives* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000494:pharmacology*
chemical_list: D000438:Alcohols; D000998:Antiviral Agents; D012717:Sesquiterpenes; D012694:Serine