title: Complex partial status epilepticus associated with anti-Hu paraneoplastic syndrome.
abstract: Although seizures can be a manifestation of paraneoplastic disorders, there are few descriptions of the association between the anti-Hu paraneoplastic syndrome and epilepsia partialis continua. A new case of refractory complex partial status epilepticus in a patient with a paraneoplastic syndrome associated with a poorly differentiated mediastinal tumor that expressed Hu antigen is described clinically, pathologically, and electrographically. We discuss the presentation of focal seizures in a disease that is characterized by diffuse pathologic involvement of the brain. The progression of EEG, MRI, and clinical findings during the course of the illness is also discussed. To our knowledge, this is the first description of paraneoplastic epilepsia partialis continua associated with diffuse pathologic abnormalities.
authors.affiliation: Department of Neurology, Hospital of the University of Pennsylvania, 3 West Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA. daj37@mail.med.upenn.edu
authors.forename: Dina A
authors.initials: DA
authors.lastname: Jacobs
authors.forename: Kar-Ming
authors.initials: KM
authors.lastname: Fung
authors.forename: Noah M
authors.initials: NM
authors.lastname: Cook
authors.forename: William W
authors.initials: WW
authors.lastname: Schalepfer
authors.forename: Herbert I
authors.initials: HI
authors.lastname: Goldberg
authors.forename: Mark M
authors.initials: MM
authors.lastname: Stecker
mesh_terms: D018450:Disease Progression; D051959:ELAV Proteins; D004569:Electroencephalography / Q000379:methods; D004660:Encephalitis / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology* / Q000378:metabolism; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000276:immunology / Q000473:pathology; D016601:RNA-Binding Proteins / Q000276:immunology* / Q000378:metabolism; D013226:Status Epilepticus / Q000150:complications* / Q000473:pathology
chemical_list: D051959:ELAV Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins