title: Production of teicoplanin by a mutant of Actinoplanes teicomyceticus.
abstract: Teicoplanin, a glucopeptide antibiotic, was produced by a mutant of Actinoplanes teicomyceticus at 300 mg l-1 using mannose and yeast extract as carbon and nitrogen sources in flask culture and at 500 mg l-1 in 5-1 jar fermenter. Teicoplanin production was 25-fold higher than in the parent strain.
authors.affiliation: Korea Research Institute of Bioscience & Biotechnology, P.O. Box 115, Yusong, Daejon 305-600, Korea.
authors.forename: Jae-Chan
authors.initials: JC
authors.lastname: Lee
authors.forename: Hae-Ryong
authors.initials: HR
authors.lastname: Park
authors.forename: Dong-Jin
authors.initials: DJ
authors.lastname: Park
authors.forename: Kwang Hee
authors.initials: KH
authors.lastname: Son
authors.forename: Ki-Hong
authors.initials: KH
authors.lastname: Yoon
authors.forename: Young-Bae
authors.initials: YB
authors.lastname: Kim
authors.forename: Chang-Jin
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D000192:Actinomycetales / Q000235:genetics* / Q000378:metabolism*; D003470:Culture Media / Q000737:chemistry; D005285:Fermentation; D007218:Industrial Microbiology / Q000379:methods*; D008358:Mannose / Q000378:metabolism; D009154:Mutation; D017334:Teicoplanin / Q000096:biosynthesis*
chemical_list: D003470:Culture Media; D017334:Teicoplanin; D008358:Mannose