Placental angiotensin II receptor AT1R in normotensive patients and its correlation between infant birth weight.
OBJECTIVE
To evaluate angiotensin II type 1 receptor (AT1R) in the third trimester placenta from normotensive women and the correlation between placental AT1R immunoreactivity and infant birth weight.


METHODS
The study was carried out on 18 healthy normotensive patients with singleton uncomplicated pregnancies. Immunohistochemistry was used to examine the localization of AT1R in the human placenta.


RESULTS
Immunohistochemistry using a monoclonal antibody showed that angiotensin II (Ang II) receptor subtype 1 is localized in the decidual cells, syncytiotrophoblast, cytotrophoblast, Hofbauer cells and vascular endothelium. In our study group of patients, we found a significant negative correlation between histological staining in placental tissue and infant birth weight.


CONCLUSIONS
It seems that the appropriate placental AT1R expression and its normal vascular and endocrine activity plays a very important role in oxygenation and nutrition of the fetus and this ensures proper fetal development and growth.
Laskowska
Marzena
M
Department of Obstetrics and Perinatology, University School of Medicine in Lublin, Jaczewskiego 8, Lublin 20-950, Poland. marzena@asklepios.am.lublin.pl
Leszczyńska-Gorzelak
Bozena
B
Oleszczuk
Jan
J
D001724:Birth Weight; D001794:Blood Pressure; D002824:Chorionic Villi / Q000378:metabolism; D003656:Decidua / Q000166:cytology / Q000378:metabolism; D005314:Embryonic and Fetal Development / Q000502:physiology; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D010920:Placenta / Q000166:cytology / Q000378:metabolism*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000502:physiology; D044140:Receptor, Angiotensin, Type 1 / Q000378:metabolism*; D012016:Reference Values; D014018:Tissue Distribution; D014327:Trophoblasts / Q000378:metabolism*
D044140:Receptor, Angiotensin, Type 1