A case of subcutaneous phaeohyphomycotic cyst due to Exophiala jeanselmei complicated with systemic lupus erythematosus.
We report a case of subcutaneous phaeohyphomycosis by Exophiala jeanselmei that appeared on the extensor surface of the left lower leg of a 34-year-old woman with systemic lupus erythematosus (SLE). The superficial symptoms were a subcutaneous nodule 2.5 x 2 cm in size discharging a serous exudate from its center. Histopathological examination revealed granulomatous changes including large numbers of neutrophils in the dermis and the subcutaneous tissues. In addition, periodic acid-Schiff-positive fungal elements consisting of many yeast-like cells and chains of cells with hyphae were seen. The statistics on E. jeanselmei infections in Japan indicated that 54 cases (24 in men and 30 in women) had been reported, of which 50 (21 in men and 29 in women) were phaeohyphomycosis, and about half had underlying diseases; and the sites of the lesions were mainly on the extremities.
Murayama
N
N
Department of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Japan. norikom@kj8.so-net.ne.jp
Takimoto
R
R
Kawai
M
M
Hiruma
M
M
Takamori
K
K
Nishimura
K
K
D000328:Adult; D003881:Dermatomycoses / Q000175:diagnosis* / Q000382:microbiology* / Q000601:surgery; D005093:Exophiala / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*