Solubilities of phenazopyridine, propranolol, and methimazole in supercritical carbon dioxide.
The equilibrium solubilities of three drugs (phenazopyridine, propranolol and methimazole) were determined at temperatures ranging from 308 to 348 K and pressures from 122 to 355 bar in supercritical CO2 by a simple and reliable static method. The crossover region was observed for phenazopyridine, propranolol and methimazole at 180 bar. The solubilities were correlated using a semi empirical model. Correlation of the results shows good self-consistency of the data obtained.
Yamini
Yadollah
Y
Department of Chemistry, School of Sciences, Tarbiat Modarres University, PO Box 14115-111, Tehran, Iran. yyamini@modares.ac.ir
Arab
Jaber
J
Asghari-Khiavi
Mehdi
M
D000319:Adrenergic beta-Antagonists / Q000737:chemistry / Q000302:isolation & purification; D000892:Anti-Infective Agents, Urinary / Q000737:chemistry / Q000302:isolation & purification; D013956:Antithyroid Agents / Q000737:chemistry / Q000302:isolation & purification; D002245:Carbon Dioxide / Q000737:chemistry*; D008713:Methimazole / Q000737:chemistry* / Q000302:isolation & purification; D010621:Phenazopyridine / Q000737:chemistry* / Q000302:isolation & purification; D011312:Pressure; D011433:Propranolol / Q000737:chemistry* / Q000302:isolation & purification; D015203:Reproducibility of Results; D012995:Solubility; D013696:Temperature
D000319:Adrenergic beta-Antagonists; D000892:Anti-Infective Agents, Urinary; D013956:Antithyroid Agents; D002245:Carbon Dioxide; D008713:Methimazole; D011433:Propranolol; D010621:Phenazopyridine