title: [A case of recurrent breast cancer with lung metastasis and overexpression of HER2 that responded to UFT and cyclophosphamide combination therapy after sequential treatments with epirubicin, taxanes, and trastuzumab].
abstract: We describe a 57-year-old woman who underwent modified mastectomy for right breast cancer (T2N0M0) with overexpression of HER2, in whom lung metastasis developed 3 years after operation. She received sequential chemotherapy, including epirubicin plus cyclophosphamide, docetaxel, paclitaxel and trastuzumab, but the lung lesion progressed after transiently showing a partial response. Oral treatment with UFT and cyclophosphamide was begun as fifth-line treatment. The lung tumor shrank after 2 months, and a partial response has been maintained during continued treatment with UFT and cyclophosphamide. No adverse effects have occurred. We regard combination therapy with oral UFT and cyclophosphamide to be useful for the management of metastatic breast cancer, even in heavily pretreated cases with overexpression of HER2.
authors.affiliation: Dept. of Surgery, Kumamoto City Hospital.
authors.forename: Reiki
authors.initials: R
authors.lastname: Nishimura
authors.forename: Kazuharu
authors.initials: K
authors.lastname: Nagao
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Miyayama
authors.forename: Shinji
authors.initials: S
authors.lastname: Okazaki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujimura
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D001952:Bridged-Ring Compounds / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004338:Drug Combinations; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D015412:Mastectomy, Segmental; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D043823:Taxoids; D005641:Tegafur / Q000008:administration & dosage; D000068878:Trastuzumab; D014498:Uracil / Q000008:administration & dosage
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D001952:Bridged-Ring Compounds; D003520:Cyclophosphamide; D004338:Drug Combinations; D015251:Epirubicin; D018719:Erb-b2 Receptor Tyrosine Kinases; D043823:Taxoids; D005641:Tegafur; D000068878:Trastuzumab; D014498:Uracil; C096910:UFT(R) drug; C080625:taxane