title: Vasoactive responses of veins isolated from the human placental chorionic plate.
abstract: The control of the blood flow within the fetoplacental circulation is poorly understood despite the essential role of the placenta in pregnancy. Our aim was to assess the vasoactive responses of veins from the placental chorionic plate. Biopsies were obtained from term placentae from uncomplicated pregnancies. Small veins from the chorionic plate were dissected free from surrounding tissue and studied using parallel wire myography. Human placental chorionic plate veins developed maintained constrictions to the thromboxane-mimetic U46619. Endothelium-dependent agonists did not promote venous relaxation. However, NO donation with the endothelial-independent agent, sodium nitroprusside, elicited significant relaxation. Venous constriction to U46619 and relaxation to sodium nitroprusside were modified by adjustment of media oxygen tension and normalization parameters. Human placental chorionic plate veins respond to vasoactive agents and may play a role in the control of the blood flow in the fetoplacental circulation.
authors.affiliation: Maternal and Fetal Health Research Centre, University of Manchester, St Mary's Hospital, Hathersage Road, M13 0JH, Manchester, UK. Mark.Wareing@man.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Wareing
authors.forename: S L
authors.initials: SL
authors.lastname: Greenwood
authors.forename: M J
authors.initials: MJ
authors.lastname: Taggart
authors.forename: P N
authors.initials: PN
authors.lastname: Baker
mesh_terms: D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / Q000494:pharmacology; D002823:Chorion / Q000098:blood supply*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005865:Gestational Age; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D009213:Myography; D009599:Nitroprusside / Q000494:pharmacology; D010101:Oxygen Consumption / Q000502:physiology; D011247:Pregnancy; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014680:Veins / Q000187:drug effects / Q000502:physiology*
chemical_list: D014662:Vasoconstrictor Agents; D009599:Nitroprusside; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid