Pathogenesis of Kaposi's sarcoma.
Kaposi's sarcoma (KS) is a disease characterized by proliferative vascular lesions, which almost invariably contain the KS-associated herpesvirus (KSHV), also called human herpesvirus 8. KSHV is a lymphotrophic and angiotrophic herpesvirus, whose genome encodes several proteins involved in proliferation, antiapoptotic functions, and inflammation. Most KS spindle cells express latent KSHV genes, but a few express lytic genes, which might be involved in angiogenic and paracrine mechanisms that contribute to KS pathogenesis. A number of tissue culture and mouse models have been established, but a comprehensive system that accurately portrays KS pathogenesis still does not exist.
Bubman
Darya
D
Pharmacology Program, Weill Graduate School of Medical Sciences of Cornell University, 1300 York Avenue, Room C406, New York, NY 10021, USA.
Cesarman
Ethel
E
D000818:Animals; D001685:Biological Factors; D018929:Cell Culture Techniques; D004195:Disease Models, Animal; D005814:Genes, Viral; D015497:HIV-1; D019288:Herpesvirus 8, Human / Q000235:genetics; D006801:Humans; D012514:Sarcoma, Kaposi / Q000209:etiology* / Q000473:pathology / Q000821:virology
D001685:Biological Factors