title: Management of lacrimal sac tumours.
abstract: OBJECTIVE
  To report a series of 15 primary lacrimal sac tumours and present an algorithm in managing this rare condition.
  
  
  METHODS
  Noncomparative interventional case series.
  
  
  METHODS
  A retrospective review of the clinical, radiological, and pathological records of 15 patients with primary lacrimal sac tumours. Main outcome measures Histologic evaluation and clinical follow-up, including tumour clearance and recurrence, were assessed.
  
  
  RESULTS
  Of the patients, 11 were female and the median age at presentation for the whole group was 59 years (range 22-94 years). The commonest tumour was non-Hodgkins B-cell lymphoma (five cases), followed by two cases each of squamous cell carcinoma and transitional cell carcinoma, one case of benign transitional papilloma, haemangiopericytoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, mixed (squamous/transitional) carcinoma, and a highly malignant undifferentiated tumour. Treatment modalities included surgery, radiotherapy and chemotherapy and, with a median follow-up of 30 months (range 2 months to 17 years), two patients had died from metastatic disease but nine patients remained without evidence of recurrent tumour.
  
  
  CONCLUSIONS
  Primary lacrimal sac tumours are extremely rare, require long-term follow-up for recurrence and metastasis, and can be fatal.
authors.affiliation: Lacrimal Clinic, Moorfields Eye Hospital, London, UK.
authors.forename: D N
authors.initials: DN
authors.lastname: Parmar
authors.forename: G E
authors.initials: GE
authors.lastname: Rose
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D005134:Eye Neoplasms / Q000473:pathology / Q000628:therapy*; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012189:Retrospective Studies; D016896:Treatment Outcome