Abamectin attenuates gastric mucosal damage induced by ethanol through activation of vagus nerve in rats.
Some type A gamma-aminobutyric acid (GABA(A)) receptor agonists are effective in protecting against the formation of stomach lesions induced by ethanol. Natural product abamectin, one of the existing GABA(A) receptor agonists, might protect against the development of gastric ulcers induced by ethanol. We investigated the protective effect of abamectin against the formation of gastric mucosal lesions induced by ethanol in rats. Abamectin (3 mg/kg, p.o.) was given to rats 1 h before administration of ethanol [4 ml of a 30% (volume/volume) solution]. Mucosal lipid peroxidation (LPO), nitric oxide (NO) levels, and ulcer index were measured 3 h after gastric surgery (vagotomy vs. sham vagotomy) in treated versus control subjects. Abamectin attenuated ethanol-induced gastric ulceration, decreased LPO regeneration, and increased NO production in the gastric mucosa of rats in the sham vagotomy group. However, this protective effect of abamectin against ethanol-induced gastric lesions was not observed in rats in the group that underwent vagotomy. These results support the suggestion that administration of abamectin ameliorated the ethanol-induced gastric mucosal injury through elevation of NO production. Activation of the vagus nerve may be involved in the abamectin-associated gastric protection against the effects of ethanol in rats.
Liu
Ming-Yie
MY
Graduate Institute of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan 704. myliu@mail.ncku.edu.tw
Chiang
James Po-Jung
JP
Hsu
Dur-Zong
DZ
Deng
Jou-Fang
JF
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D002492:Central Nervous System Depressants / Q000633:toxicity*; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000473:pathology; D005978:Glutathione / Q000378:metabolism; D007202:Indicators and Reagents; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009573:Nitrites / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D014628:Vagotomy; D014630:Vagus Nerve / Q000187:drug effects*
D000871:Anthelmintics; D002492:Central Nervous System Depressants; D007202:Indicators and Reagents; D009573:Nitrites; D000431:Ethanol; C048324:abamectin; D007559:Ivermectin; D005978:Glutathione