title: HFE genotype and transferrin saturation in the United States.
abstract: OBJECTIVE
  Examine the penetrance (defined by high transferrin saturation [TS]) of C282Y and H63D in the U.S. population.
  
  
  METHODS
  5171 participants from the Third National Health and Nutrition Examination Survey, 1992 to 1994.
  
  
  RESULTS
  77.1% (95% confidence interval [CI], 2.3, 95.1) of men and 51.9% (95% CI, 0, 84.2) of women with C282Y homozygosity had high TS. The associations of H63D homozygosity with high TS were stronger in people aged 50 years or older than in younger persons. Among Mexican-Americans, simple H63D heterozygosity was associated with high TS.
  
  
  CONCLUSIONS
  The associations between HFE genotype and high TS may vary by sex, age, and ethnic group.
authors.affiliation: Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Cogswell
authors.forename: Margaret L
authors.initials: ML
authors.lastname: Gallagher
authors.forename: Karen K
authors.initials: KK
authors.lastname: Steinberg
authors.forename: Samuel P
authors.initials: SP
authors.lastname: Caudill PhD
authors.forename: Anne C
authors.initials: AC
authors.lastname: Looker
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Bowman
authors.forename: Elaine W
authors.initials: EW
authors.lastname: Gunter
authors.forename: Adele L
authors.initials: AL
authors.lastname: Franks
authors.forename: Glen A
authors.initials: GA
authors.lastname: Satten
authors.forename: Muin J
authors.initials: MJ
authors.lastname: Khoury
authors.forename: Laurence M
authors.initials: LM
authors.lastname: Grummer-Strawn
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005838:Genotype; D000071020:Hemochromatosis Protein; D006579:Heterozygote; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D015233:Models, Statistical; D016017:Odds Ratio; D014168:Transferrin / Q000235:genetics*; D014481:United States
chemical_list: C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D014168:Transferrin