title: Targeted molecular mechanisms of epoetin alfa.
abstract: Despite therapeutic improvements and ongoing efforts to develop more efficacious therapies, the majority of lung cancer patients face a poor prognosis. Therefore, the primary goal of current treatment is palliation, improvement and maintenance of quality of life (QOL), and (modest) prolongation of survival. Anemia frequently occurs in lung cancer patients and has been associated with decreased QOL, impaired treatment outcomes, and shortened survival time. Furthermore, anemia is a causative factor of tumor hypoxia, which compromises the efficacy of chemotherapy and radiotherapy. Thus, correction of even mild anemia seems to have a beneficial effect on QOL and cancer treatment outcomes. The current article describes the basis and mechanism for the use of recombinant human erythropoietin (rHuEPO, epoetin alfa), a molecular targeted therapy, for the treatment of cancer-related anemia, with a focus on lung cancer. Epoetin alfa has proven efficacy and safety in correcting anemia and improving QOL based on numerous clinical studies and over a decade of clinical practice. In addition, emerging data show that epoetin alfa may offer potential benefits beyond treating anemia, specifically in terms of treatment outcomes and cognitive function. Future research needs to be conducted to explore the potential for epoetin alfa to improve survival time in lung cancer patients.
authors.affiliation: Department of Medical Oncology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA. cj_langer@fccc.edu
authors.forename: Corey J
authors.initials: CJ
authors.lastname: Langer
authors.forename: Fred R
authors.initials: FR
authors.lastname: Hirsch
authors.forename: Hernan
authors.initials: H
authors.lastname: Cortés-Funes
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Sawyer
authors.forename: Nick
authors.initials: N
authors.lastname: Thatcher
mesh_terms: D000740:Anemia / Q000188:drug therapy* / Q000209:etiology*; D002986:Clinical Trials as Topic; D003071:Cognition; D000068817:Epoetin Alfa; D004921:Erythropoietin / Q000494:pharmacology*; D006397:Hematinics / Q000494:pharmacology*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy*; D010166:Palliative Care; D011788:Quality of Life; D011994:Recombinant Proteins; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D006397:Hematinics; D011994:Recombinant Proteins; D004921:Erythropoietin; D000068817:Epoetin Alfa