title: New sesterterpene sulfates from the sponge Darwinella australensis.
abstract: Three new sesterterpene sulfates, halisulfates 8-10 (1-3), were isolated from the Australian sponge Darwinella australensis. The structures of these compounds were determined by combined spectroscopic methods. The stereochemistry of the decalin moiety was assigned on the basis of NMR interpretations. Halisulfates 9 and 10 inhibited cell division of sea urchin eggs in moderate concentration.
authors.affiliation: Marine Natural Products Chemistry Laboratory, Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of Russian Academy of Sciences, Vladivostok 690022, Russia.
authors.forename: Tatyana N
authors.initials: TN
authors.lastname: Makarieva
authors.forename: Jung-Rae
authors.initials: JR
authors.lastname: Rho
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Elena A
authors.initials: EA
authors.lastname: Santalova
authors.forename: Valentin
authors.initials: V
authors.lastname: Stonik
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004531:Eggs; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D012426:Russia; D012617:Sea Urchins / Q000187:drug effects; D054830:Sesterterpenes; D013329:Structure-Activity Relationship; D013463:Sulfuric Acid Esters / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D054830:Sesterterpenes; D013463:Sulfuric Acid Esters; D013729:Terpenes