title: Long-term effects of hormone replacement therapy on bone mineral density in girls oophorectomized in adolescence.
abstract: The object of this study was to examine the effects of hormone replacement therapy (HRT) on bone mineral density (BMD) and physical development in oophorectomized adolescent girls. Two adolescent girls had bilateral ovaries removed as the treatment of advanced ovarian neoplasms at 12 years of age, and have been receiving HRT for more than 10 years. The changes in BMD and physical development were recorded. Both patients entered puberty and developed mature female physiques, despite the 3 years' absence of estrogen exposure immediately after oophorectomy. BMD recovered soon after the start of HRT and was kept within the normal range. Normal physical development, including bone mineral density, can be achieved with HRT in adolescent girls castrated before puberty.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Medical School, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kanaoka
authors.forename: K
authors.initials: K
authors.lastname: Honda
authors.forename: O
authors.initials: O
authors.lastname: Ishiko
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: S
authors.initials: S
authors.lastname: Ogita
mesh_terms: D001827:Body Height; D015519:Bone Density; D001940:Breast / Q000254:growth & development; D002648:Child; D015914:Estrogen Replacement Therapy; D005260:Female; D005272:Femur Neck; D005836:Genitalia, Female / Q000254:growth & development; D006801:Humans; D008159:Lumbar Vertebrae; D010051:Ovarian Neoplasms / Q000601:surgery; D010052:Ovariectomy; D011627:Puberty