Somatosensory evoked potential and histopathological investigations in ischaemia-induced brain damage: effects of trimetazidine in rats.
We studied the protective effects of trimetazidine (TMZ) on brain damage by means of somatosensory evoked potentials (SEP) in rats. The TMZ group did not show any statistically significant difference from the control group with respect to SEPs. However, the percentage of cells with ischaemic cell damage in hippocampal regions was significantly smaller in the TMZ group than the control group. Trimetazidine reduced the number of damaged cells in the cerebral tissue during the ischaemia-reperfusion damage. It was suggested that higher doses of trimetazidine may further reduce the number of cells with ischaemic damage.
Oğuzhanoğlu
Atilla
A
Pamukkale University, Medical School, Department of Neurology, Denizli, Turkey. aoguzhan@pamukkale.edu.tr
Kurt
Tülay
T
Ortaç
Ragip
R
Turman
Bülent
B
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D016923:Cell Death / Q000187:drug effects; D016009:Chi-Square Distribution; D004195:Disease Models, Animal; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000517:prevention & control; D018709:Statistics, Nonparametric; D014292:Trimetazidine / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology
D018696:Neuroprotective Agents; D014665:Vasodilator Agents; D014292:Trimetazidine