[Correlation of clinical features with pathology in chronic viral hepatitis].
BACKGROUND
To investigate the correlation of clinical features with pathology in chronic viral hepatitis (CH).


METHODS
Analyses of single factor and multiple factors of serum biochemical indices, imaging examination results, symptoms and signs with degree of pathological lesion of hepatic tissue in 973 cases of CH were conducted. Meanwhile, the hepatic functional index (AAPEA index) was used to investigate the role of serum biochemical indices in diagnosis of CH.


RESULTS
In these patients with CH,the severity of hepatic lesion was closely correlated to symptoms and signs, biochemical indices such as PTA, ALT, TBIL, ALB, A/G, gamma-globulin (gamma-G) by electrophoresis, AST and cholinesterase (CHE) as well as splenic thickness. AST was superior to ALT in reflecting degree of hepatic inflammatory activity. The total mistaken judgment rate of multiple factor analysis was 28.1%. The correlation coefficient of AAPEA index to degrees of hepatic inflammatory activity, fibrosis and pathological grading was 0.559, 0.545 and 0.529, respectively (P<0.000 1)


CONCLUSIONS
The biochemical indices such as PTA, ALT, TBIL, ALB, A/G, gammaG, AST, CHE and the determination of splenic thickness by ultrasonography B could reflect hepatic pathological changes to certain extent. AST was superior to ALT in reflecting degree of hepatic inflammatory activity. Incorrect judgment rate was high in determination of moderate and severe CH by multiple factor analysis. Conformity rate between AAPEA index and pathological diagnosis was better than any of them alone in diagnosing CH.
Xin
Shao-jie
SJ
The 302nd Hospital of PLA, Beijing 100039, China.
Zhang
Ling-xia
LX
Zhu
Chuan-lin
CL
Hu
Jing-hua
JH
Duan
Xue-zhang
XZ
You
Shao-li
SL
Hu
Ling-ping
LP
Zou
Zheng-sheng
ZS
Mao
Yuan-li
YL
Huangpu
Yu-shan
YS
D000293:Adolescent; D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle; D002648:Child; D002675:Child, Preschool; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis / Q000473:pathology*; D019698:Hepatitis C, Chronic / Q000097:blood / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000000981:diagnostic imaging; D014463:Ultrasonography