title: The effects of low doses of Senna occidentalis seeds on broiler chickens.
abstract: The effects of 0.5%, 0.3% and 0.1% w/w concentrations of Senna occidentalis (So) seed mixed with commercial ration were studied in 18 groups of 32 broiler chicks each, from 1 day to 49 days of age. Three groups were fed one of the rations throughout their lives (TL). Three other groups were fed one of the rations from the 1st to the 28th day of life (starter phase, SP), and the final 3 groups were fed one of the rations from the 29th to 49th day (finisher phase, FP). Each experimental group was matched by a control group fed the same diet over the same period but without the inclusion of So. All the animals were killed at 49 days of age, and blood was collected from 10 birds in each group for biochemical studies (ALT, AST, GGT, LDH, UA). A complete necropsy was performed on 3 birds from each group. No significant differences in the biochemical parameters in the serum were found between the control and experimental chicks, but animals treated with 0.5% So in groups FP and TL, gained less weight and chicks that received 0.3% So or 0.5% So in the ration throughout life (TL) had a larger feed conversion ratio. Besides this, degenerative changes were found in the striated skeletal muscle in the chest, in the myocardium and in the liver in the animals that received the higher concentrations of So seeds.
authors.affiliation: Animal Health Center, Biological Institute of São Paulo, Av. Conselheiro Rodrigues Alves, 1252, CEP 04014-002, São Paulo, Brazil. haragucihi@.biologico.sp.gov.br
authors.forename: M
authors.initials: M
authors.lastname: Haraguchi
authors.forename: M L Z
authors.initials: ML
authors.lastname: Dagli
authors.forename: P C
authors.initials: PC
authors.lastname: Raspantini
authors.forename: S L
authors.initials: SL
authors.lastname: Górniak
mesh_terms: D000818:Animals; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects / Q000473:pathology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology; D009135:Muscular Diseases / Q000097:blood / Q000139:chemically induced / Q000473:pathology; D010947:Plants, Toxic / Q000633:toxicity*; D011201:Poultry Diseases / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D012639:Seeds / Q000737:chemistry*; D029846:Senna Plant / Q000737:chemistry*; D015430:Weight Gain / Q000187:drug effects