Determination of volatile residual solvents in traditional Chinese medicines by headspace solid-phase microextraction and cryogenic gas chromatography with flame ionization detection.
A method based on headspace solid-phase microextraction and cryogenic gas chromatography with flame ionization detection was developed for the determination of volatile residual solvents in traditional Chinese medicines. A laboratory-made cryogenic chromatographic system was used for the separation of 15 kinds of residual solvents. During the analysis, a 65 microm PDMS/DVB fiber was used to extract the residual solvents, the extraction time was controlled at 0 degrees C for 15 min, and the NaCl content of the sample was maintained at 30%. The limits of detection ranged from 0.08 (for octane) to 5000 microg/L (for ethanol), and the relative standard deviations were < 8%. The recoveries from spiked samples ranged from 88 to 112%. Trace levels of residual solvents in several traditional Chinese medicines were effectively identified and quantified.
Liu
Jiemin
J
Chinese Academy of Sciences, Research Center for Eco-Environmental Sciences, PO Box 2871, Beijing 100085, People's Republic of China.
Zhou
Qunfang
Q
Jiang
Guibin
G
Liu
Jingfu
J
Liu
Jiyan
J
Wen
Meijuan
M
D002138:Calibration; D002849:Chromatography, Gas; D005410:Flame Ionization; D008516:Medicine, Chinese Traditional; D012997:Solvents / Q000032:analysis*
D012997:Solvents