title: Serum levels of interleukin 6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF) and elastase in aseptic prosthetic loosening.
abstract: In synovial-like membranes from failed total hip prostheses, an increased level of cytokines and cellular mediators has been identified. We compared two matched groups of patients with total hip arthroplasty (THA)--one with surgically proven component loosening and one without. We measured serum levels of interleukin 6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF) and elastase. Soluble interleukin 2 receptor (sIL-2r) was also measured to exclude any hypersensitivity reaction. We found no significant difference in serum values between groups. Neither were there any differences with respect to implant material, mode of fixation, and periprosthetic osteolysis. In contrast to previous reports, our results suggest that serum levels of cytokines and cellular mediators may not be affected in aseptic loosening.
authors.affiliation: Department of Orthopaedics, University of Heidelberg, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany. Nikolaus.Streich@ok.uni-heidelberg.de
authors.forename: Nikolaus A
authors.initials: NA
authors.lastname: Streich
authors.forename: Steffen J
authors.initials: SJ
authors.lastname: Breusch
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schneider
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005547:Foreign Bodies / Q000276:immunology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood*; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000097:blood*; D011475:Prosthesis Failure
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D010196:Pancreatic Elastase