title: Successful use of oral linezolid as a single active agent in endocarditis unresponsive to conventional antibiotic therapy.
abstract: Treatment of resistant gram-positive endocarditis is difficult. We report a case of resistant Staphylococcus epidermidis endocarditis that failed to respond to conventional antibiotic therapy but was treated successfully with an oral regimen of a new antibiotic, linezolid as a single active agent. This case report demonstrates the use of linezolid as an effective alternative to conventional antibiotics in such cases.
authors.affiliation: Department of Cardiology, Castle Hill Hospital, Cottingham, East Yorkshire, UK. drvinod12@hotmail.com
authors.forename: V
authors.initials: V
authors.lastname: Ravindran
authors.forename: J
authors.initials: J
authors.lastname: John
authors.forename: G C
authors.initials: GC
authors.lastname: Kaye
authors.forename: R E
authors.initials: RE
authors.lastname: Meigh
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000284:Administration, Oral; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D000069349:Linezolid; D023303:Oxazolidinones / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013212:Staphylococcus epidermidis / Q000302:isolation & purification; D016896:Treatment Outcome
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid