title: Pulmonary involvement in a case of juvenile-onset recurrent respiratory papillomatosis.
abstract: Juvenile-onset recurrent respiratory papillomatosis is primarily a disease of children and adolescents. Although most patients experience spontaneous regression at a later age, some patients continue to be affected throughout their lives. We report the case of a 35-year-old woman with a 33-year history of juvenile-onset recurrent respiratory papillomatosis who developed pulmonary dissemination with malignant transformation. Malignant transformation is the most feared sequela of pulmonary dissemination, and it should be addressed aggressively. If treated promptly, the patient can enjoy prolonged survival. Computed tomography is superior to plain radiography for detecting and evaluating the extent of disease.
authors.affiliation: Department of Otolaryngology, Children's Hospital of Michigan, Wayne State University, 5E UHC, 4201 St. Antoine, Detroit, MI 48201, USA. smckay@wayne.edu
authors.forename: Shawn P
authors.initials: SP
authors.lastname: McKay
authors.forename: Shai Y
authors.initials: SY
authors.lastname: Shinhar
authors.forename: Walter M
authors.initials: WM
authors.lastname: Belenky
mesh_terms: D000328:Adult; D017668:Age of Onset; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D003131:Combined Modality Therapy; D018450:Disease Progression; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008171:Lung Diseases / Q000503:physiopathology / Q000601:surgery; D008175:Lung Neoplasms / Q000209:etiology / Q000601:surgery; D010212:Papilloma / Q000821:virology*; D030361:Papillomavirus Infections / Q000150:complications*; D011013:Pneumonectomy; D012008:Recurrence; D012140:Respiratory Tract Diseases / Q000628:therapy / Q000821:virology*