title: Basic science of closed head injuries and spinal cord injuries.
abstract: Traumatic CNS injury is one of the most important health issues in our society and is a risk to all athletes, both in competitive and recreational sports. Our understanding of the pathophysiology has improved tremendously in the last 20 years. This progress has led to the identification of several possible treatments for improving outcome following spinal cord injury and traumatic brain injury. As no panacea exists, improvements in experimental models have empowered researchers in their search for novel therapeutic strategies.
authors.affiliation: Department of Neuroscience, University of Virginia, PO Box 800212, Charlottesville, VA 22908-0212, USA. doo5a@virginia.edu
authors.forename: David O
authors.initials: DO
authors.lastname: Okonkwo
authors.forename: James R
authors.initials: JR
authors.lastname: Stone
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D016718:Arachidonic Acid / Q000378:metabolism; D001265:Athletic Injuries / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D001930:Brain Injuries / Q000209:etiology / Q000503:physiopathology; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D016166:Free Radical Scavengers / Q000627:therapeutic use; D016489:Head Injuries, Closed / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology; D008565:Membrane Proteins; D028361:Mitochondrial Diseases / Q000209:etiology; D023421:Models, Animal; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D013119:Spinal Cord Injuries / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D016166:Free Radical Scavengers; D007527:Isoenzymes; D008565:Membrane Proteins; D016718:Arachidonic Acid; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases