title: Effect of combined treatment with selective sigma ligands and amantadine in the forced swimming test in rats.
abstract: The obtained results showed that the selective sigma, receptor agonist, SA4503 (but not siramesine, the sigma2 receptor agonist), given alone, exerted an antidepressant-like activity in the forced swimming test in rats. Amantadine (an uncompetitive NMDA receptor antagonist) potentiated or revealed the effect of SA4503 or siramesine, respectively, in this model.
authors.affiliation: Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Kraków, Poland.
authors.forename: Grazyna
authors.initials: G
authors.lastname: Skuza
authors.forename: Zofia
authors.initials: Z
authors.lastname: Rogóz
mesh_terms: D000547:Amantadine / Q000494:pharmacology* / Q000627:therapeutic use*; D000818:Animals; D003863:Depression / Q000188:drug therapy; D004359:Drug Therapy, Combination; D008024:Ligands; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D017480:Receptors, sigma / Q000819:agonists* / Q000502:physiology; D013550:Swimming / Q000502:physiology
chemical_list: D008024:Ligands; D017480:Receptors, sigma; D000547:Amantadine