G-proteins as transducers in transmembrane signalling.
The G-protein-mediated signalling system has evolved as one of the most widely used transmembrane signalling mechanisms in mammalian organisms. All mammalian cells express G-protein-coupled receptors as well as several types of heterotrimeric G-proteins and effectors. G-protein-mediated signalling is involved in many physiological and pathological processes. This review summarizes some general aspects of G-protein-mediated signalling and focusses on recent data especially from studies in mutant mice which have elucidated some of the cellular and biological functions of heterotrimeric G-prtoteins.
Offermanns
Stefan
S
Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany. stefan.offermanns@urz.uni-heidelberg.de
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D032383:Myocytes, Cardiac / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D015539:Platelet Activation / Q000276:immunology; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D012677:Sensation / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D009435:Synaptic Transmission
D043562:Receptors, G-Protein-Coupled; D019204:GTP-Binding Proteins