title: Pyrrolidine carbamate nucleic acids: synthesis and DNA binding studies.
abstract: An efficient solid phase synthesis of pyrrolidine carbamate nucleic acids is reported. The protected (2S, 4S)-4-aminopyrrolidine-2-methanol with nucleobases thymine and cytosine attached to the ring nitrogen through an acetyl linker can be activated as nitrophenyl carbonates for the synthesis of dimer, trimer and oligomers.
authors.affiliation: Division of Organic Chemistry (Synthesis), National Chemical Laboratory, 411008, Pune, India.
authors.lastname: Meena
authors.forename: Vaijayanti A
authors.initials: VA
authors.lastname: Kumar
mesh_terms: D001483:Base Sequence; D002219:Carbamates / Q000737:chemistry*; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation / Q000528:radiation effects; D011759:Pyrrolidines / Q000737:chemistry*; D013696:Temperature; D014466:Ultraviolet Rays
chemical_list: D002219:Carbamates; D011759:Pyrrolidines; D004247:DNA; C032519:pyrrolidine