title: Flurbiprofen, a unique non-steroidal anti-inflammatory drug with antimicrobial activity against Trichophyton, Microsporum and Epidermophyton species.
abstract: OBJECTIVE
  The objective of this study was to determine the antifungal activity of flurbiprofen against dermatophytes like Trichophyton, Microsporum and Epidermophyton species.
  
  
  RESULTS
  Susceptibility tests were performed against dermatophytes like Trichophyton, Microsporum and Epidermophyton species by the microbroth dilution method. Among the dermatophytes tested, Trichophyton, Microsporum and Epidermophyton species are remarkably susceptible to this compound (MIC(50): 8-16 microg ml(-1)). A yeast pathogen, Candida albicans, and a bacterium, Staphylococcus aureus, are also susceptible to flurbiprofen.
  
  
  CONCLUSIONS
  Flurbiprofen is a non-steroidal anti-inflammatory compound with strong antifungal activity, which is not found in two well known and medically used antifungal organic acids like benzoic and salicylic acids.
  
  
  CONCLUSIONS
  The present action of flurbiprofen on microbes indicates its future prospects as an antimicrobial agent against dermatophytes and yeast pathogens. However, in view of the anti-inflammatory property of flurbiprofen, its antifungal action may provide an additional advantage for use as a skin ointment.
authors.affiliation: Department of Biology, Memorial University of Newfoundland, St John's, Newfoundland A1B 3X9, Canada. chowdhur@mail.nih.gov
authors.forename: B
authors.initials: B
authors.lastname: Chowdhury
authors.forename: M
authors.initials: M
authors.lastname: Adak
authors.forename: S K
authors.initials: SK
authors.lastname: Bose
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D003881:Dermatomycoses / Q000188:drug therapy; D004821:Epidermophyton / Q000187:drug effects; D005480:Flurbiprofen / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008864:Microsporum / Q000187:drug effects; D009824:Ointments; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000935:Antifungal Agents; D009824:Ointments; D005480:Flurbiprofen