title: General pharmacology of indole [2',3':3,4]pyrido[2,1-b]quinazolinium- 5,7,8,13-tetrahydro-14-methyl-5-oxo-chloride, a new anti-dementia agent.
abstract: The general pharmacological properties of indolo[2',3':3,4]pyrido[2,1-b]quinazolinium-5,7,8,13-tetrahydro-14- methyl-5-oxo-chloride (dehydroevodiamine-HCl, DHED, CAS 67909-49-3), a new potential anti-dementia agent, were studied to investigate side effects using various experimental animals. Both oral and intraperitoneal administration of DHED had no effects on the central nervous system except that they showed an analgesic activity. DHED had no significant effect on heart rate, blood pressure and coronary flow in isolated rat hearts. DHED had negligible effects on the autonomic nervous system and smooth muscle in isolated rat ileum, rat vas deferens and rat aorta. DHED did not influence the gastrointestinal system except that it inhibited the intestinal travel of a charcoal meal in mice. Neither blood coagulation mechanism nor liver function was affected by DHED. Therefore, it is concluded from these general pharmacological studies that DHED does not induce any serious side effects at the dose levels showing anticholinesterase and memory enhancing activities in the experimental animals.
authors.affiliation: Department of Pharmacology, College of Medicine, National Creative Research Initiative Centre for Alzheimer's Dementia, Neuroscience Research Institute, MRC, Seoul National University, Seoul, Korea.
authors.forename: Cheol Hyoung
authors.initials: CH
authors.lastname: Park
authors.forename: Se Hoon
authors.initials: SH
authors.lastname: Choi
authors.forename: Chan-Hyung
authors.initials: CH
authors.lastname: Kim
authors.forename: Ji-Heui
authors.initials: JH
authors.lastname: Seo
authors.forename: Ja Wook
authors.initials: JW
authors.lastname: Koo
authors.forename: Jong-Cheol
authors.initials: JC
authors.lastname: Rah
authors.forename: Hye-Sun
authors.initials: HS
authors.lastname: Kim
authors.forename: Sung-Jin
authors.initials: SJ
authors.lastname: Jeong
authors.forename: Wan-Seok
authors.initials: WS
authors.lastname: Joo
authors.forename: Young-Jae
authors.initials: YJ
authors.lastname: Lee
authors.forename: Yong Sik
authors.initials: YS
authors.lastname: Kim
authors.forename: Myung-Suk
authors.initials: MS
authors.lastname: Kim
authors.forename: Yoo-Hun
authors.initials: YH
authors.lastname: Suh
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D003704:Dementia / Q000188:drug therapy*; D004064:Digestive System / Q000187:drug effects; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009130:Muscle, Smooth / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D012137:Respiratory System / Q000187:drug effects
chemical_list: D000470:Alkaloids; C028633:dehydroevodiamine