title: Hypocholesterolemic activity of hesperetin derivatives.
abstract: Hesperetin ester and ether derivatives possessing a long alkyl chain were synthesized for examining their hypocholesterolemic activities in high cholesterol-fed mice. Hesperetin 7-O-lauryl ether (4b) and hesperetin 7-O-oleyl ether (4e) exhibited strong cholesterol-lowering effects.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, 52 Oun, Yusong, Taejon 305-333, Republic of Korea.
authors.forename: Tae-Sook
authors.initials: TS
authors.lastname: Jeong
authors.forename: Eun Eai
authors.initials: EE
authors.lastname: Kim
authors.forename: Chul-Ho
authors.initials: CH
authors.lastname: Lee
authors.forename: Jung-Hoon
authors.initials: JH
authors.lastname: Oh
authors.forename: Surk-Sik
authors.initials: SS
authors.lastname: Moon
authors.forename: Woo Song
authors.initials: WS
authors.lastname: Lee
authors.forename: Goo-Taeg
authors.initials: GT
authors.lastname: Oh
authors.forename: Sangku
authors.initials: S
authors.lastname: Lee
authors.forename: Song-Hae
authors.initials: SH
authors.lastname: Bok
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004987:Ethers / Q000138:chemical synthesis / Q000494:pharmacology; D006569:Hesperidin / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy; D051379:Mice; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D004987:Ethers; C484475:hesperetin 7-O-lauryl ether; C484476:hesperetin 7-O-oleyl ether; D002784:Cholesterol; D006569:Hesperidin; C013015:hesperetin