Biochemical targets of nitric oxide-induced toxicity.
Nitric oxide (NO) has become one of the most intensively studied molecules in recent years. Although its beneficial role has been well established, a large body of adverse effects was also attributed to NO and/or its red-ox derivatives, implicating a dual (friend and foe) role of this agent in biological systems. Peroxynitrite (ONOO-), a product from the reaction of NO with superoxide anion (O2.-) was recognized as a potent toxic endogenous agent. This review will discus some of the discrete and/or silent chemical aspects of both NO produced from L-arginine and peroxynitrite in an attempt to elucidate the potential biochemical target(s) of NO- and/or peroxynitrite-induced toxicity.
Grudziński
Ireneusz P
IP
Department of Applied Physiology, Military Institute of Hygiene and Epidemiology, Kozielska St., 01-163 Warsaw, Poland.
D001120:Arginine / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000009:adverse effects* / Q000737:chemistry; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D030421:Peroxynitrous Acid / Q000737:chemistry; D013481:Superoxides / Q000378:metabolism
D013481:Superoxides; D030421:Peroxynitrous Acid; D009569:Nitric Oxide; D001120:Arginine