title: Progressive supranuclear palsy: where are we now?
abstract: This review provides an update on progressive supranuclear palsy (PSP, or Steele-Richardson-Olszewski disease), an adult-onset neurodegenerative disorder characterised by early postural instability, which leads to falls, and a vertical supranuclear-gaze palsy. Recent epidemiological studies have shown that the disorder is more common than previously recognised, that it is commonly misdiagnosed, and that it may present to a wide range of hospital specialists. The diagnosis of PSP hinges on clinical acumen. Attempts to identify a suitable biomarker in the CSF or a specific and sensitive imaging or neurophysiological technique have so far failed to have a significant effect on the diagnostic process. Better understanding of the molecular pathology of PSP has highlighted the importance of tau-protein accumulation and tau-genotype susceptibility in its pathogenesis. No drug treatment significantly and consistently benefits patients, and novel therapies are urgently required.
authors.affiliation: University of Newcastle upon Tyne, Newcastle upon Tyne, UK. d.j.burn@ncl.ac.uk
authors.forename: David J
authors.initials: DJ
authors.lastname: Burn
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lees
mesh_terms: D001921:Brain / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*