Parasitological and morphological findings in porcine isosporosis after treatment with symmetrical triazintriones.
Neonatal porcine isosporosis is known to cause serious economic losses in piglet farms by causing severe enteritis with dehydration, weight loss and reduced development in the affected animals, predominantly during the first weeks of life. In the present study, piglets experimentally infected with Isospora suis were treated with Bay Vi 9143, a symmetrical triazintrione, at different days post-infection. As shown by clinical and pathological examinations, Bay Vi 9143 is effective against the asexual and sexual stages of I. suis at all selected treatment times. However, the therapeutic use at an early stage of asexual multiplication is most effective before the onset of clinical symptoms.
Bach
Ute
U
BHC-PH-P-Toxicologic Pathology, Pharma Research Center, Bayer AG, 42096 Wuppertal, Germany. ute.bach.ub@bayer-ag.de
Kalthoff
Victoria
V
Mundt
Hans-Christian
HC
Popp
Andreas
A
Rinke
Matthias
M
Daugschies
Arwid
A
Lüttge
Bernhard
B
D000818:Animals; D000831:Animals, Newborn; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007421:Intestine, Small / Q000469:parasitology / Q000473:pathology; D007549:Isospora / Q000187:drug effects*; D021865:Isosporiasis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008854:Microscopy, Electron; D013553:Swine Diseases / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology
D000981:Antiprotozoal Agents