Novel guanosine-cytidine dinucleoside that self-assembles into a trimeric supramolecule.
[reaction: see text] Synthesis and assembly studies of a guanosine-cytidine dinucleoside 1 that self-assembles into a trimeric supramolecule (I) are presented. Dinucleoside 1 was obtained by utilizing two consecutive palladium-catalyzed cross-coupling reactions. Ensemble I was analyzed by ESI-MS, NMR spectroscopies, size exclusion chromatography (SEC), and vapor pressure osmometry (VPO).
Sessler
Jonathan L
JL
Department of Chemistry and Biochemistry and Institute of Cellular and Molecular Biology, 1 University Station - A5300, The University of Texas at Austin, 78712-0165, USA. sessler@mail.utexas.edu
Jayawickramarajah
Janarthanan
J
Sathiosatham
Muhunthan
M
Sherman
Courtney L
CL
Brodbelt
Jennifer S
JS
D002850:Chromatography, Gel; D003562:Cytidine / Q000031:analogs & derivatives / Q000737:chemistry*; D006151:Guanosine / Q000031:analogs & derivatives / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D010165:Palladium / Q000737:chemistry; D011312:Pressure; D021241:Spectrometry, Mass, Electrospray Ionization; D014835:Volatilization
D006151:Guanosine; D003562:Cytidine; D010165:Palladium