Effect of electrolyzed oxidizing water and hydrocolloid occlusive dressings on excised burn-wounds in rats.
OBJECTIVE
To study the efficacy of electrolyzed oxidizing water (EOW) and hydrocolloid occlusive dressings in the acceleration of epithelialization in excised burn-wounds in rats.


METHODS
Each of the anesthetized Sprague-Dawley rats (n=28) was subjected to a third-degree burn that covered approximately 10% of the total body surface area. Rats were assigned into four groups: Group I (no irrigation), Group II (irrigation with physiologic saline), Group III (irrigation with EOW) and Group IV (hydrocolloid occlusive dressing after EOW irrigation). Wounds were observed macroscopically until complete epithelialization was present, then the epithelialized wounds were examined microscopically.


RESULTS
Healing of the burn wounds was the fastest in Group IV treated with hydrocolloid occlusive dressing together with EOW. Although extensive regenerative epidermis was seen in each Group, the proliferations of lymphocytes and macrophages associated with dense collagen deposition were more extensive in Group II, III and IV than in Group I. These findings were particularly evident in Group III and IV.


CONCLUSIONS
Wound Healing may be accelerated by applying a hydrocolloid occlusive dressing on burn surfaces after they are cleaned with EOW.
Xin
Hua
H
Department of Thoracic Surgery, China-Japan Union Hospital, Jilin University, Jilin 130031, China. xinhua7254@yahoo.com.cn
Zheng
Ya-juan
YJ
Hajime
Nakae
N
Han
Zhen-guo
ZG
D000818:Animals; D002056:Burns / Q000628:therapy*; D003102:Colloids / Q000627:therapeutic use*; D008297:Male; D009779:Occlusive Dressings; D051381:Rats; D017207:Rats, Sprague-Dawley; D014867:Water / Q000008:administration & dosage*; D014945:Wound Healing
D003102:Colloids; D014867:Water