title: [New trends in the therapy of cryptococcosis in AIDS patients].
abstract: The Authors report the clinical and microbiological findings about a 6-months follow up of 9 AIDS-patients with Cryptococcosis. Among these, 7 patients suffered from meningo-encephalitis and 2 from haematogenous infection. The fungicidal treatment during acute illness, included the administration of Amphotericin B (0.6 mg/Kg/die i.v.) plus Flucytosine (100 mg/kg/die i.v.) during the first 15 days followed from itraconazole at doses of 400 mg/die in a single administration, during the following 15 days. The chronic suppressive therapy included itraconazole at doses of 200 mg/die p.o. indefinitely. During the 6-months follow up, one patient died of polymicrobial pneumonia and another of hepatic failure related to a reactivation of a previous HCV hepatitis. In 2 patients the presence of multiple nodular lesions in the cerebral CT scan, related to cryptococcal granulomas, was associated to a persistence of positive liquoral cultures and to a poor prognosis. In 3 patients with meningo-encephalitis, the three drugs regimen was quite effective in eradicating the neurological infection and no relapses were observed during the 6-months follow up. The 2 patients with hematogenous infection alone, didn't relapse during the 6-months follow up.
authors.affiliation: Divisione di Malattie Infettive e Tropicali, Universita degli Studi di Pavia-IRCCS, Policlinico San Matteo.
authors.forename: A
authors.initials: A
authors.lastname: Parisi
authors.forename: A
authors.initials: A
authors.lastname: Malfitano
authors.forename: R
authors.initials: R
authors.lastname: Bruno
authors.forename: W
authors.initials: W
authors.lastname: Calderon
authors.forename: P
authors.initials: P
authors.lastname: Sacchi
authors.forename: S
authors.initials: S
authors.lastname: Patruno
authors.forename: G
authors.initials: G
authors.lastname: Filice