title: A brief history of blood filtration: clot screens, microaggregate removal, and leukocyte reduction.
abstract: A historical perspective of the evolution of blood filtration is presented. Topics addressed include recognition of aggregates in blood as mediators of morbidity, targeted for removal with gross clot screens, and evolution through the implementation of universal leukocyte reduction. Future directions for the development of blood filters are also described.
authors.affiliation: Pall Medical, Pall Corporation, East Hills, NY 11548, USA. Sam_Wortham@pall.com
authors.forename: Samuel T
authors.initials: ST
authors.lastname: Wortham
authors.forename: Girolamo A
authors.initials: GA
authors.lastname: Ortolano
authors.forename: Barry
authors.initials: B
authors.lastname: Wenz
mesh_terms: D001781:Blood Component Removal / Q000266:history; D001803:Blood Transfusion / Q000266:history* / Q000295:instrumentation / Q000379:methods; D005374:Filtration / Q000266:history* / Q000295:instrumentation; D049670:History, 17th Century; D049671:History, 18th Century; D049673:History, 20th Century; D006801:Humans; D007962:Leukocytes