title: Antibacterial coumarins from Angelica gigas roots.
abstract: Systematic fractionation of Angelica gigas roots led to the isolation of linear furano(pyrano)coumarins such as bergapten (1), decursinol angelate (2), decursin (3), nodakenetin (4) and nodakenin (5). The antibacterial activities of those compounds against pathogenic bacteria were investigated. Among the compounds tested, decursinol angelate (2) and decursin (3) exhibited significant antibacterial activity against Bacillus subtilis with the minimum inhibitory concentrations (MICs) of 50 and 12.5 microg/mL, respectively.
authors.affiliation: Natural Products Research Institute, Seoul National University, Seoul 110-460, Korea.
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Lee
authors.forename: Dong-Sun
authors.initials: DS
authors.lastname: Shin
authors.forename: Ju Sun
authors.initials: JS
authors.lastname: Kim
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
mesh_terms: D029969:Angelica / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D003374:Coumarins; D010936:Plant Extracts