title: Allergic contact dermatitis in venous leg ulcer patients.
abstract: Our aim was to determine the frequency and nature of contact sensitivity in venous leg ulcer patients in Lanarkshire. We performed patch testing with the European standard series, antimicrobials and medicaments on 200 patients referred to our leg ulcer clinics. Positive patch tests were found in 136 (68%) patients. Multiple allergies occurred in 102 (51%). The most frequent allergen groups were fragrances (30.5%), antimicrobials (19.5%), topical excipients (19.5%), rubber accelerators (13.5%) and topical corticosteroids (8%). We also found a high prevalence of positive patch tests to Intrasite gel (9.5%) and Hioxyl cream (8.5%), medicaments which are commonly used to treat leg ulcers in our area. Contact sensitivity is common in venous leg ulcer patients and has important implications for patient management. The allergens involved vary depending on local nursing practice. We suggest that all venous leg ulcer patients be patch tested with a locally relevant patch test series.
authors.affiliation: Department of Dermatology, Monklands District General Hospital, Lanarkshire, Scotland. sherinetavadia@aol.com
authors.forename: S
authors.initials: S
authors.lastname: Tavadia
authors.forename: J
authors.initials: J
authors.lastname: Bianchi
authors.forename: R S
authors.initials: RS
authors.lastname: Dawe
authors.forename: M
authors.initials: M
authors.lastname: McEvoy
authors.forename: E
authors.initials: E
authors.lastname: Wiggins
authors.forename: E
authors.initials: E
authors.lastname: Hamill
authors.forename: M
authors.initials: M
authors.lastname: Urcelay
authors.forename: A M M
authors.initials: AM
authors.lastname: Strong
authors.forename: W S
authors.initials: WS
authors.lastname: Douglas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000485:Allergens / Q000009:adverse effects*; D000890:Anti-Infective Agents / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007871:Leg Ulcer; D008297:Male; D008875:Middle Aged; D009824:Ointments / Q000009:adverse effects; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects; D015995:Prevalence; D012606:Scotland / Q000453:epidemiology
chemical_list: D000485:Allergens; D000890:Anti-Infective Agents; D009824:Ointments; D010476:Perfume