title: Diallyl disulfide ameliorates gentamicin-induced oxidative stress and nephropathy in rats.
abstract: Experimental evidences suggest a role of reactive oxygen species in gentamicin-induced nephropathy in rats. Therefore, we investigated if diallyl disulfide, a garlic-derived compound with antioxidant properties, has a renoprotective effect in this experimental model. Four groups of rats were studied: (1) control, (2) gentamicin treated subcutaneously with gentamicin (70 mg/kg/12 h/4 days), (3) diallyl disulfide treated intragastrically with diallyl disulfide (50 mg/kg/24 h/4 days), and (4) gentamicin + diallyl disulfide treated with gentamicin + diallyl disulfide. Gentamicin induced (a) nephrotoxicity, (b) increase in renal oxidative stress, and (c) decrease in the activity of manganese superoxide dismutase, glutathione peroxidase, and glutathione reductase. Diallyl disulfide ameliorated these changes induced by gentamicin. The mechanism by which diallyl disulfide has a renoprotective effect in gentamicin-induced acute renal failure in rats may be related, at least in part, to the amelioration in the oxidative stress and the preservation in the activity of the antioxidant enzymes in kidney.
authors.affiliation: Department of Biology, Faculty of Chemistry, Universidad Nacional Autónoma de México (UNAM), 04510, México, D.F., Mexico. pedraza@servidor.unam.mx
authors.forename: José
authors.initials: J
authors.lastname: Pedraza-Chaverrí
authors.forename: Ana E
authors.initials: AE
authors.lastname: González-Orozco
authors.forename: Perla D
authors.initials: PD
authors.lastname: Maldonado
authors.forename: Diana
authors.initials: D
authors.lastname: Barrera
authors.forename: Omar N
authors.initials: ON
authors.lastname: Medina-Campos
authors.forename: Rogelio
authors.initials: R
authors.lastname: Hernández-Pando
mesh_terms: D000498:Allyl Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D015415:Biomarkers / Q000032:analysis; D001806:Blood Urea Nitrogen; D004220:Disulfides / Q000494:pharmacology / Q000627:therapeutic use*; D005737:Garlic / Q000737:chemistry; D005839:Gentamicins / Q000009:adverse effects*; D007668:Kidney / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000498:Allyl Compounds; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D015415:Biomarkers; D004220:Disulfides; D005839:Gentamicins; C028009:diallyl disulfide; D013482:Superoxide Dismutase