Bridging mitotic defects and clinical diagnoses.
Anaphase bridges are known to play important roles in generating the genetic instability of cancer cells. Now anaphase bridges are shown to be a candidate for a new diagnostic tool to distinguish between chromosomally stable and unstable tumors. These results emphasize the importance of mitotic defects to cancer and begin to translate our understanding of mitotic errors in tumor cells into tools the clinician can use.
Saunders
William
W
Department of Biological Sciences, 258 Crawford Hall, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. wsaund@pitt.edu.
D000705:Anaphase / Q000235:genetics*; D000782:Aneuploidy; D002869:Chromosome Aberrations; D002877:Chromosomes, Human; D006801:Humans; D018895:Microsatellite Repeats; D008938:Mitosis / Q000235:genetics*; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology