title: The effect of chronic exposure to 835.62 MHz FDMA or 847.74 MHz CDMA radiofrequency radiation on the incidence of spontaneous tumors in rats.
abstract: This study was designed to determine whether chronic exposure to radiofrequency (RF) radiation from cellular phones increased the incidence of spontaneous tumors in F344 rats. Eighty male and 80 female rats were randomly placed in each of three irradiation groups. The sham group received no irradiation; the Frequency Division Multiple Access (FDMA) group was exposed to 835.62 MHz FDMA RF radiation; and the Code Division Multiple Access (CDMA) group was exposed to 847.74 MHz CDMA RF radiation. Rats were irradiated 4 h per day, 5 days per week over 2 years. The nominal time-averaged specific absorption rate (SAR) in the brain for the irradiated animals was 0.85 +/- 0.34 W/kg (mean +/- SD) per time-averaged watt of antenna power. Antennas were driven with a time-averaged power of 1.50 +/- 0.25 W (range). That is, the nominal time-averaged brain SAR was 1.3 +/- 0.5 W/kg (mean +/- SD). This number was an average from several measurement locations inside the brain, and it takes into account changes in animal weight and head position during irradiation. All major organs were evaluated grossly and histologically. The number of tumors, tumor types and incidence of hyperplasia for each organ were recorded. There were no significant differences among final body weights or survival days for either males or females in any group. No significant differences were found between treated and sham-exposed animals for any tumor in any organ. We conclude that chronic exposure to 835.62 MHz FDMA or 847.74 MHz CDMA RF radiation had no significant effect on the incidence of spontaneous tumors in F344 rats.
authors.affiliation: Division of Comparative Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. marie@dcm.wustl.edu
authors.forename: Marie
authors.initials: M
authors.lastname: La Regina
authors.forename: Eduardo G
authors.initials: EG
authors.lastname: Moros
authors.forename: William F
authors.initials: WF
authors.lastname: Pickard
authors.forename: William L
authors.initials: WL
authors.lastname: Straube
authors.forename: Jack
authors.initials: J
authors.lastname: Baty
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Roti Roti
mesh_terms: D000818:Animals; D040421:Cell Phone; D016543:Central Nervous System Neoplasms / Q000209:etiology / Q000473:pathology; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006965:Hyperplasia / Q000209:etiology / Q000473:pathology; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology*; D009928:Organ Specificity; D011829:Radiation Dosage; D011846:Radio Waves / Q000009:adverse effects* / Q000145:classification; D051381:Rats; D011916:Rats, Inbred F344; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity