Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura.
We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p13.2 in 360 migraine patients, 220 with migraine without aura (MO) and 140 with migraine with aura (MA), and 200 controls, by analysing two polymorphic markers, a G142A transition in exon 10 and a triallelic (TA)n repeat in exon 18. The allelic distribution of the (TA)n polymorphism was significantly different between migraine without aura (MO) and both controls and migraine with aura (MA). We suggest a possible predisposition to MO in the studied population through this polymorphism or another polymorphism in linkage disequilibrium with (TA)n.
Mochi
Mirella
M
Department of Neurological Sciences, University of Bologna Medical School, Bologna, Clinica Neurologica, Via U. Foscolo 7, 40123 Bologna, Italy. genetica@neuro.unibo.it
Cevoli
Sabina
S
Cortelli
Pietro
P
Pierangeli
Giulia
G
Scapoli
Chiara
C
Soriani
Stefano
S
Montagna
Pasquale
P
D000293:Adolescent; D000328:Adult; D000409:Alanine / Q000235:genetics; D000483:Alleles; D002648:Child; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D005091:Exons; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005998:Glycine / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D020326:Migraine without Aura / Q000097:blood / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011973:Receptors, LDL / Q000235:genetics*
D011973:Receptors, LDL; D000409:Alanine; D005998:Glycine