[Effect of zhidan huayu oral liquid on mycoplasmal pneumonia in mice].
OBJECTIVE
To study the effect of Chinese herbal medicine for activating blood circulation to remove stasis in treating mycoplasmal pneumonia (MP) in mice.


METHODS
One hundered and thirty-five BALB/C mice were randomly divided into the control group, the MP model groups IF1 and IF2, the Rexithromycin treated groups LH1 and LH2, and the Rexithromycin plus Zhidan Huayu oral liquid treated groups LZ1 and LZ2. The changes of pathologic scoring, graphic analysis and thrombus counting of lung were observed.


RESULTS
In the 3rd day of treatment, the pathologic scores in LH1 and LZ1 were significantly lower and their values of graphic analysis were significantly higher than those in IF1 (P < 0.01 and P < 0.05 respectively), but with inflammation of lung significantly milder than that in IF1. The difference of therapeutic effect between LH1 and LZ1 was insignificant. In the 4th day of treatment, pathologic scores in LZ2 was significantly lower and value of graphic analysis higher than those in IF2 respectively (P < 0.01), with the improvement better than that of LH2 (P < 0.05). In 3rd and 4th day of treatment, the difference of thrombus counting between the Rexithromycin treated groups and the model groups was insignificant (P > 0.05), but it was significantly lower in the combined treated groups than that in the model groups (P < 0.05).


CONCLUSIONS
Zhidan Huayu oral liquid could assist Rexithromycin to alleviate the condition of mice with MP, its mechanism may be related with the effect of reducing thrombosis and improving microcirculation.
Liu
Xiao-hong
XH
Department of Pediatrics, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050.
Hou
An-cun
AC
Xin
De-li
DL
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000098:blood supply; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008833:Microcirculation / Q000187:drug effects; D008517:Phytotherapy; D011019:Pneumonia, Mycoplasma / Q000473:pathology*; D011897:Random Allocation; D015575:Roxithromycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D015575:Roxithromycin