title: Intravenous catheter declotting: same outcomes with lower dose urokinase?
abstract: This study aims to assess, in terms of catheter salvage and economic cost, the effect of a low dose (2000 IU) urokinase lock technique to clear multilumen central venous catheters (CVC) and peripherally inserted central catheters (PICCs) when occluded. A total of 100 catheters were included in the analysis. Results indicate this lower dose technique to be effective in restoring the patency of multilumen CVCs, but not as effective when clearing PICCs. No catheters were lost because of occlusion.
authors.affiliation: Department of Nursing Education and Research, Bellvitge University Hospital, Feixa Llarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain. lalajuve@csub.scs.es
authors.forename: Maria Eulàlia
authors.initials: ME
authors.lastname: Juvé
mesh_terms: D000328:Adult; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002406:Catheterization, Peripheral / Q000009:adverse effects*; D002408:Catheters, Indwelling / Q000009:adverse effects*; D015400:Clinical Nursing Research; D003362:Cost-Benefit Analysis; D004305:Dose-Response Relationship, Drug; D004868:Equipment Failure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000008:administration & dosage*; D012189:Retrospective Studies; D012307:Risk Factors; D007507:Therapeutic Irrigation / Q000191:economics / Q000379:methods*; D013927:Thrombosis / Q000209:etiology* / Q000517:prevention & control*; D013997:Time Factors; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*; D014654:Vascular Patency
chemical_list: D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator