title: Complementary DNA sequences encoding the rat MHC class II RT1-Bu and RT1-Du alpha and beta chains.
abstract: The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively. Here we describe the complementary DNA (cDNA) sequence encoding the alpha and beta chains of both the RT1-B and RT1-D locus genes of the rat RT1u haplotype. We have found entire sequence identity between five different inbred rat strains of the RT1u haplotype, which differs from previously published, incomplete sequences. This information is of considerable value for experimental studies of transplantation immunity and autoimmune disease.
authors.affiliation: Department of Surgery, University of Cambridge School of Clinical Medicine, Box 202, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK.
authors.forename: Alistair J
authors.initials: AJ
authors.lastname: Easterfield
authors.forename: J Andrew
authors.initials: JA
authors.lastname: Bradley
authors.forename: Eleanor M
authors.initials: EM
authors.lastname: Bolton
mesh_terms: D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary; D006649:Histocompatibility Antigens / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D051381:Rats
chemical_list: D018076:DNA, Complementary; D006649:Histocompatibility Antigens; D000949:Histocompatibility Antigens Class II; C038353:histocompatibility antigens RT, rat