Circadian activity rhythms in high-alcohol-preferring and low-alcohol-preferring mice.
The circadian periods of high-alcohol-preferring (HAP) and low-alcohol-preferring (LAP) selected lines of mice were compared. The mice were ethanol-naive. Circadian periods were calculated from records of running-wheel activity in constant dark. The number of daily wheel revolutions and body weights of the two lines of mice were also compared. The HAP line had a shorter period of wheel running than that of the LAP lines. The HAP mice also had a tendency to run more on wheels than did LAP mice. These findings support the suggestion that genes affecting ethanol consumption in mice have pleiotropic effects on circadian period.
Hofstetter
John R
JR
Richard L. Roudebush VA Medical Center, and Department of Psychiatry, Indiana University School of Medicine, Indianapolis, 46202, USA. jhofstet@iupui.edu
Grahame
Nicholas J
NJ
Mayeda
Aimee R
AR
D000428:Alcohol Drinking / Q000235:genetics* / Q000523:psychology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002940:Circadian Rhythm / Q000235:genetics* / Q000502:physiology*; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000502:physiology; D017440:Photoperiod; D013045:Species Specificity