title: Organosulfur compounds from garlic (Allium sativum) oxidizing canine erythrocytes.
abstract: The sulfurous acid ester, trans-sulfurous acid allyl ester 3-allylsulfanyl-allyl ester 8, along with two known thiosulfinates was isolated from the aqueous ethanol extract of garlic (Allium sativum). The chemical structure of 8 was determined on the basis of spectroscopic data including high resolution mass and two-dimensional NMR techniques. All of these compounds induced methemoglobin formation in a canine erythrocyte suspension in vitro resulting in the oxidation of canine erythrocytes. This is the first report of sulfurous acid ester showing oxidant activity in canine erythrocytes.
authors.affiliation: Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, 060-8589, Japan.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Qiuhui
authors.initials: Q
authors.lastname: Hu
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamato
authors.forename: Keun-Woo
authors.initials: KW
authors.lastname: Lee
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Maede
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Yoshihara
mesh_terms: D000476:Alkanesulfonates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D001681:Biological Assay; D004285:Dogs; D004912:Erythrocytes / Q000187:drug effects*; D000431:Ethanol; D005737:Garlic; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000737:chemistry; D013441:Sulfinic Acids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000476:Alkanesulfonates; D010936:Plant Extracts; D013441:Sulfinic Acids; C478023:sulfurous acid allyl ester 3-allylsulfanylallyl ester; C100040:thiosulfinic acids; D000431:Ethanol