Single hospital experience of TRALI.
BACKGROUND
TRALI is a serious adverse effect of blood transfusion. There is evidence that the condition is underrecognized and underreported.


METHODS
This study was an observational study carried out in a single hospital.


RESULTS
Eleven cases of TRALI were recognized over 12 years. In 10 cases the implicated donor unit was FFP and in 1 case uncertain. All implicated donors were parous women. In 4 cases the presumed causative antibodies were to an HLA class II antigen only. Specific anti-neutrophil antibodies, possibly causative, were detected in 1 case only. Ten of the 11 cases required mechanical ventilatory support. Five persons died as a result of the TRALI. The observed incidence of TRALI caused by FFP is 1 in 7900 units transfused.


CONCLUSIONS
TRALI is the most common serious adverse effect of blood transfusion in our hospital. Antibodies to HLA class II antigens should be looked for routinely when investigating a possible case of TRALI.
Wallis
Jonathan P
JP
Department of Hematology, Freeman Hospital, and the National Blood Service, Newcastle upon Tyne, UK. jonathan.walls@tfh.nuth.northy.nhs.uk
Lubenko
Anatole
A
Wells
Angus W
AW
Chapman
Catherine E
CE
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis; D016913:Blood Component Transfusion; D001782:Blood Donors; D001793:Blood Preservation; D002675:Child, Preschool; D015925:Cryopreservation; D005260:Female; D006761:Hospitals / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D007958:Leukocyte Count; D008171:Lung Diseases / Q000097:blood / Q000453:epidemiology* / Q000209:etiology* / Q000276:immunology; D008297:Male; D009504:Neutrophils / Q000473:pathology; D012709:Serum Albumin / Q000032:analysis; D065227:Transfusion Reaction
D000906:Antibodies; D012709:Serum Albumin