Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line.
Several bioactive acetogenins were selective against 1A9 (ovarian cancer) cell replication but did not show a corresponding hyperactivity against other cell lines. The most active compound (26, molvizarin) was a selective inhibitor of 1A9 cell replication with a potency (ED(50) = 5 pg/mL) of over 1 million times more than that for other cell lines.
Nakanishi
Yuka
Y
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7360, USA.
Chang
Fang-Rong
FR
Liaw
Chih-Chuang
CC
Wu
Yang-Chang
YC
Bastow
Kenneth F
KF
Lee
Kuo-Hsiung
KH
D019840:2-Propanol / Q000737:chemistry*; D029061:Annonaceae / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D010051:Ovarian Neoplasms; D028321:Plant Preparations / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005227:Fatty Acids; D005663:Furans; D028321:Plant Preparations; D019840:2-Propanol