Convenient synthesis of oligodeoxyribonucleotides bearing arabinofuranosyl pyrimidine derivatives and its duplex formation with complementary DNA.
The oligodeoxyribonucleotides bearing 2,2'-anhydro-beta-D-arabinofuranosyluracil derivatives were synthesized and the modified residue was converted to beta-D-arabinofuranosyluracil derivatives or beta-D-arabinofuranosylisocytosine derivatives by post-synthetic modification method. The melting profiles of their ODNs with complementary DNA were studied.
Ozaki
Hiroaki
H
Department of Chemistry, Faculty of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan. ozaki@chem.gunma-u.ac.jp
Nakajima
Kiyohiro
K
Tatsui
Kaoru
K
Izumi
Chieko
C
Kuwahara
Masayasu
M
Sawai
Hiroaki
H
D001089:Arabinose / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D018076:DNA, Complementary / Q000737:chemistry*; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000138:chemical synthesis*; D021241:Spectrometry, Mass, Electrospray Ionization
D018076:DNA, Complementary; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D011743:Pyrimidines; C431714:arabinofuranose; D001089:Arabinose