title: Expression of functional markers in acute lymphoblastic leukemia.
abstract: We analyzed surface antigens, multidrug resistance (MDR) parameters (PGP, MRP, LRP), tissue infiltration parameters (CD18, CD44, VCAM, MMP2), receptors for colony stimulating factors (G-CSFr, GM-CSFr) and cell cycle parameters (Ki-67, topoisomerase IIalpha) in 86 patients with acute lymphoblastic leukemia (ALL). LRP, PGP and CD18 were associated with poor clinical outcome, and LRP expression was related with CD18, CD44 and G-CSFr. Of the cell cycle parameters, Ki-67 (+) fraction was increased in ALL with hepato-splenomegaly and extramedullary involvement. In conclusion, analysis of LRP, PGP, CD18 and Ki-67 could be helpful to predict the clinical behavior of ALL.
authors.affiliation: Department of Clinical Pathology, College of Medicine, St. Mary's Hospital, The Catholic University of Korea, 62 Youido-dong Youngdeungpo-gu, Seoul 150-713, South Korea.
authors.forename: Eun-Jee
authors.initials: EJ
authors.lastname: Oh
authors.forename: Jimin
authors.initials: J
authors.lastname: Kahng
authors.forename: Yonggoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Myungshin
authors.initials: M
authors.lastname: Kim
authors.forename: Jihyang
authors.initials: J
authors.lastname: Lim
authors.forename: Chang Suk
authors.initials: CS
authors.lastname: Kang
authors.forename: Woo Sung
authors.initials: WS
authors.lastname: Min
authors.forename: Bin
authors.initials: B
authors.lastname: Cho
authors.forename: Ahwon
authors.initials: A
authors.lastname: Lee
authors.forename: Kyo Young
authors.initials: KY
authors.lastname: Lee
authors.forename: Won Il
authors.initials: WI
authors.lastname: Kim
authors.forename: Sang In
authors.initials: SI
authors.lastname: Shim
authors.forename: Kyungja
authors.initials: K
authors.lastname: Han
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000954:Antigens, Surface / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology; D015815:Cell Adhesion Molecules; D002453:Cell Cycle; D002465:Cell Movement; D002648:Child; D002675:Child, Preschool; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques; D015999:Multivariate Analysis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011379:Prognosis; D016184:Receptors, Colony-Stimulating Factor / Q000032:analysis
chemical_list: D018528:ATP-Binding Cassette Transporters; D000954:Antigens, Surface; D015415:Biomarkers; D015815:Cell Adhesion Molecules; D016184:Receptors, Colony-Stimulating Factor