title: Invasive thymoma with paraneoplastic retinopathy.
abstract: A 60-year-old man was admitted for progressive visual loss in both eyes. He was diagnosed with retinopathy and chest computed tomography revealed an invasive thymoma. In western blot analysis, serum autoantibodies against recoverin, photoreceptor-specific calcium-binding protein, and heat shock cognate protein 70 which were identified as the cause of cancer-associated retinopathy (CAR). Immunofluorescence staining showed that thymoma cells also expressed recoverin. These observations strongly suggested that similar pathogenesis of CAR was involved in the presented case.
authors.affiliation: Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
authors.forename: Gen
authors.initials: G
authors.lastname: Yamada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohguro
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Aketa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Itoh
authors.forename: Noriharu
authors.initials: N
authors.lastname: Shijubo
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Osamutaro
authors.initials: O
authors.lastname: Fujiwara
authors.forename: Masaaki
authors.initials: M
authors.lastname: Satoh
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohtsuka
authors.forename: Shosaku
authors.initials: S
authors.lastname: Abe
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D015153:Blotting, Western; D002135:Calcium-Binding Proteins / Q000378:metabolism; D005136:Eye Proteins; D016650:Fluorescein-5-isothiocyanate; D019084:Fluorescent Antibody Technique, Indirect; D051597:Hippocalcin; D006801:Humans; D008074:Lipoproteins; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009419:Nerve Tissue Proteins; D010257:Paraneoplastic Syndromes / Q000378:metabolism / Q000473:pathology*; D051603:Recoverin; D012164:Retinal Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D013934:Thymectomy; D013945:Thymoma / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D013953:Thymus Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; C496731:RCVRN protein, human; D051603:Recoverin; D051597:Hippocalcin; D016650:Fluorescein-5-isothiocyanate