[The 3H-thymidine incorporation into G0 human lymphocytes induced by low doses of UVC radiation].
The 3H-thymidine incorporation in human lymphocytes of healthy donors induced by UVC radiation under doses 0.0008-60 J/m2 was investigated. It was shown that the incorporation of 3H-thymidine increases under doses in interval 0.1-20 and is constant under doses higher than 20 J/m2. Under doses in interval 0.006-0.03 J/m2 near a half of all samples had the level of incorporation increased in comparison with control samples. We connect the presence, absence or variability of this effect with individual peculiarities of cells and with different activity of cell subpopulations that are different on morphological and physiological characteristics. The hypothesis about the role of this factor in the influence of low doses of pathogenic agents (UVC and X-radiation, chemical compounds) on human lymphocytes is discussed.
Ermakov
A V
AV
Research Centre for Medical Genetics, Moscow, 115478 Russia.
Konradov
A A
AA
Spitkovskiĭ
D M
DM
D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects*; D016192:Resting Phase, Cell Cycle / Q000502:physiology / Q000528:radiation effects*; D013936:Thymidine / Q000378:metabolism*; D014316:Tritium; D014466:Ultraviolet Rays / Q000009:adverse effects
D014316:Tritium; D004247:DNA; D013936:Thymidine