title: Unraveling severe sepsis: why did OPTIMIST fail and what's next?
authors.forename: Derek C
authors.initials: DC
authors.lastname: Angus
authors.forename: Mark A
authors.initials: MA
authors.lastname: Crowther
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D006801:Humans; D008074:Lipoproteins / Q000627:therapeutic use*; D011506:Proteins / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D008074:Lipoproteins; D011506:Proteins; D011994:Recombinant Proteins; C051928:lipoprotein-associated coagulation inhibitor; C400709:Tifacogin