Effects of benidipine hydrochloride on autonomic nervous activity in hypertensive patients with high- and low-salt diets.
The effects of benidipine hydrochloride (CAS 91559-74-5, Coniel) on autonomic nervous activity in hypertensive patients with high- and low-salt diets were investigated. Six patients having a urinary sodium excretion of 80 mEq/day or less (low salt group) and 6 patients having a urinary sodium excretion of 200 mEq/day or more (high salt group) were orally given benidipine hydrochloride (4 mg). Before and four weeks after the treatment with benidipine, 24-h circadian variation in blood pressure and 24-h Holter electrocardiogram (ECG) were recorded. The low frequency power spectrum of heart rate (LF power; 0.04-0.15 Hz), high frequency power spectrum of heart rate (HF power; 0.15-0.40 Hz), and the ratio of LF to HF (LF/HF) were calculated, and these parameters were averaged every hour in every subject. HF power was significantly lower and LF/HF ratio was significantly higher in the high-salt group than in the low-salt group before the treatment. However, the benidipine treatment significantly increased the HF power in both groups, particularly in the high-salt group, and significantly decreased the LF/HF ratio in both groups. Moreover, there was no significant difference in the antihypertensive effect of benidipine between the high- and low-salt intake groups. These results suggest that benidipine favourably influences blood pressure and autonomic nervous activity in hypertensive patients with a high-salt intake. It is concluded that benidipine may be useful for improving the development of salt-induced hypertension and its accompanying haemodynamic responses.
Nomura
Masahiro
M
Department of Digestion and Cardiovascular Medicine, School of Medicine, University of Tokushima, Tokushima, Japan. nomura@clin.med.tokushima-u.ac.jp
Nakaya
Yutaka
Y
Uemura
Eiko
E
Sawa
Yuko
Y
Iga
Akiko
A
Kageyama
Norihito
N
Nakayama
Toru
T
Kusunoki
Kanji
K
Kawano
Tomohito
T
Katoh
Kansei
K
Okamoto
Hiroshi
H
Nishikado
Akiyoshi
A
Saito
Ken
K
Ito
Susumu
S
D000368:Aged; D001341:Autonomic Nervous System / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D004039:Diet, Sodium-Restricted; D004095:Dihydropyridines / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012982:Sodium, Dietary / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D012982:Sodium, Dietary; C061004:benidipine