Accessory proteins for melanocortin signaling: attractin and mahogunin.
Switching from eumelanin to pheomelanin synthesis during hair growth is accomplished by transient synthesis of Agouti protein, an inverse agonist for the melanocortin-1 receptor (Mc1r). The coat color mutations mahogany and mahoganoid prevent hair follicle melanocytes from responding to Agouti protein. The gene mutated in mahogany, which is also known as Attractin (Atrn), encodes a type I transmembrane protein that functions as an accessory receptor for Agouti protein. We have recently determined that the gene mutated in mahoganoid, which is also known as Mahogunin (Mgrn1), encodes an E3 ubiquitin ligase. Like Attractin, Mahogunin is conserved in invertebrate genomes, and its absence causes a pleiotropic phenotype that includes spongiform neurodegeneration.
He
Lin
L
Departments of Pediatrics and Genetics and the Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA.
Eldridge
Adam G
AG
Jackson
Peter K
PK
Gunn
Teresa M
TM
Barsh
Gregory S
GS
D054366:Agouti Signaling Protein; D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology; D010641:Phenotype; D010858:Pigmentation / Q000502:physiology; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D018043:Receptors, Corticotropin / Q000378:metabolism*; D044101:Receptors, Melanocortin; D016415:Sequence Alignment; D015398:Signal Transduction / Q000502:physiology*; D044767:Ubiquitin-Protein Ligases
C515182:ASIP protein, human; C492192:ATRN protein, human; D054366:Agouti Signaling Protein; D002352:Carrier Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011506:Proteins; D018043:Receptors, Corticotropin; D044101:Receptors, Melanocortin; C515183:a protein, mouse; C470689:Mgrn1 protein, mouse; D044767:Ubiquitin-Protein Ligases