title: Polarographic determination of flubendazole in spiked human urine and plasma.
abstract: The voltammetric behavior of flubendazole was studied using direct current (DCt), differential pulse (DPP) and alternating current (ACt) polarography. The drug manifests a cathodic wave in 20% v/v formic acid solution. The wave was characterized as being irreversible, diffusion-controlled with limited adsorption properties. The diffusion current-concentration relationship was found to be rectilinear over the range 3.2-14.4 microg/ml and 0.1 to 12.8 microg/ml, using DCt and DPP modes, respectively, with minimum detectability of 0.161 microg/ml (5.14 x 10(-7) M) and 0.0.057 microg/ml (1.82 x 10(-8) M) using DCt and DPP modes, respectively. Furthermore, the proposed method was applied to the in-vitro determination of flubendazole in spiked human urine and plasma adopting the DPP technique. The percentage recoveries were 100.20+/-0.62 and 97.42+/-0.95, respectively.
authors.affiliation: Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt. nel_enany@mans.edu.eg
authors.forename: N
authors.initials: N
authors.lastname: El-Enany
authors.forename: F
authors.initials: F
authors.lastname: Belal
authors.forename: M
authors.initials: M
authors.lastname: Rizk
mesh_terms: D000327:Adsorption; D000704:Analysis of Variance; D000969:Antinematodal Agents / Q000097:blood* / Q000652:urine*; D004058:Diffusion; D006801:Humans; D008463:Mebendazole / Q000031:analogs & derivatives* / Q000097:blood* / Q000652:urine*; D011048:Polarography / Q000379:methods; D012680:Sensitivity and Specificity
chemical_list: D000969:Antinematodal Agents; D008463:Mebendazole; C018945:flubendazole