[Familial susceptibility to aminoglycoside ototoxicity due to the A1555G mutation in the mitochondrial DNA].
OBJECTIVE
The A1555G mutation in the mitochondrial genome causes sensorineural hearing loss and familial aminoglycoside ototoxicity.


METHODS
Screening for the A1555G mutation was performed on 72 patients with nonsyndromic sensorineural hearing loss.


RESULTS
The A1555G mutation was identified in 15 patients (20.8%). All of them presented maternal relatives with deafness. Individuals with the A1555G mutation that had been treated with aminoglycosides developed more severe hearing loss.


CONCLUSIONS
The A1555G mutation should be screened in individuals with maternal relatives with hearing loss before administering aminoglycosides.
Gallo-Terán
Jaime
J
Servicio de Otorrinolaringología. Hospital Marqués de Valdecilla. Santander. Cantabria. Spain.
Morales-Angulo
Carmelo
C
del Castillo
Ignacio
I
Moreno-Pelayo
Miguel Angel
MA
Mazón
Angel
A
Moreno
Felipe
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D034381:Hearing Loss / Q000139:chemically induced* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010375:Pedigree
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004272:DNA, Mitochondrial