Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors.
The melanotropin peptides alpha-MSH, gamma-MSH, and beta-MSH are believed to be the natural ligands for the four melanocortin receptors, MC1R, MC3R, MC4R, and MC5R. However, these peptides generally have low selectivity for these receptors. We report on some approaches to the development of selective agonists and antagonists peptide ligands for these receptors.
Hruby
Victor J
VJ
Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA. hruby@u.arizona.edu
Cai
Minying
M
Grieco
Paolo
P
Han
Guoxia
G
Kavarana
Malcolm
M
Trivedi
Dev
D
D000595:Amino Acid Sequence; D000818:Animals; D015195:Drug Design; D006801:Humans; D008024:Ligands; D009074:Melanocyte-Stimulating Hormones / Q000737:chemistry* / Q000378:metabolism; D018043:Receptors, Corticotropin / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D044101:Receptors, Melanocortin; D013379:Substrate Specificity
D008024:Ligands; D018043:Receptors, Corticotropin; D044101:Receptors, Melanocortin; D009074:Melanocyte-Stimulating Hormones