Plasma adiponectin increases postprandially in obese, but not in lean, subjects.
OBJECTIVE
We investigated the acute responses of plasma adiponectin levels to a test meal in lean and obese subjects.


METHODS
We studied 13 lean and 11 obese subjects after a 10-hour overnight fast. Glucose, insulin, and adiponectin concentrations were measured at baseline and 15, 30, 60, 120, and 180 minutes after a fixed breakfast.


RESULTS
At baseline, fasting adiponectin concentrations were lower in the obese group vs. the lean group [mean (95% confidence interval): 2.9 (2.1 to 4.1) microg/mL vs. 8.6 (6.5 to 11.3) microg/mL], but rose 4-fold postprandially in the obese group, reaching a peak at 60 minutes [baseline: 2.9 (2.1 to 4.1) microg/mL vs. 60 minutes: 12.1 (8.5 to 17.4) microg/mL; p< 0.0001] and remaining elevated for the remainder of the study. There were no postprandial changes in plasma adiponectin concentrations in lean subjects.


CONCLUSIONS
This increase of adiponectin concentrations in obese individuals might have important beneficial effects on postprandial glucose and lipid metabolism and might be viewed as a mechanism for maintaining normal glucose tolerance in those who are obese and insulin resistant.
English
Patrick J
PJ
The University of Liverpool Diabetes and Endocrinology Research Group, Clinical Sciences Centre, Liverpool, United Kingdom.
Coughlin
Steven R
SR
Hayden
Katharine
K
Malik
Iqbal A
IA
Wilding
John P H
JP
D052242:Adiponectin; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D005215:Fasting; D005260:Female; D005502:Food; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D007700:Kinetics; D008297:Male; D009765:Obesity / Q000097:blood*; D011506:Proteins / Q000032:analysis*
D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins