title: Generalized eczema induced by nadroparin.
abstract: The case of a 39-year-old female with generalized eczema following sodium nadroparin administration was referred to us. Positive patch-tests for several low molecular weight heparins (LMWH), but negative for unfractionated heparins (UFH) and tinzaparin were obtained. Furthermore, intradermal tests gave positive results to sodium and calcium heparin, while only subcutaneous challenge showed tinzaparin sensitivity. In summary, in heparin type IV hypersensitivity diagnosis, the intradermal test seems to be an eligible tool, rather than patch-test.
authors.affiliation: Servicio de Alergia, Hospital de León, Spain. jestrada@hleo.insalud.es
authors.forename: J L
authors.initials: JL
authors.lastname: Estrada Rodriguez
authors.forename: F
authors.initials: F
authors.lastname: Gozalo Reques
authors.forename: J
authors.initials: J
authors.lastname: Ortiz de Urbina
authors.forename: B
authors.initials: B
authors.lastname: Matilla
authors.forename: M A
authors.initials: MA
authors.lastname: Rodriguez Prieto
authors.forename: N A
authors.initials: NA
authors.lastname: Gonzalez Moran
mesh_terms: D000328:Adult; D004485:Eczema / Q000139:chemically induced*; D005188:False Negative Reactions; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006801:Humans; D007428:Intradermal Tests; D017762:Nadroparin / Q000009:adverse effects*; D010328:Patch Tests
chemical_list: D005343:Fibrinolytic Agents; D017762:Nadroparin