Effect of combined treatment with selective sigma ligands and amantadine in the forced swimming test in rats.
The obtained results showed that the selective sigma, receptor agonist, SA4503 (but not siramesine, the sigma2 receptor agonist), given alone, exerted an antidepressant-like activity in the forced swimming test in rats. Amantadine (an uncompetitive NMDA receptor antagonist) potentiated or revealed the effect of SA4503 or siramesine, respectively, in this model.
Skuza
Grazyna
G
Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Kraków, Poland.
Rogóz
Zofia
Z
D000547:Amantadine / Q000494:pharmacology* / Q000627:therapeutic use*; D000818:Animals; D003863:Depression / Q000188:drug therapy; D004359:Drug Therapy, Combination; D008024:Ligands; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D017480:Receptors, sigma / Q000819:agonists* / Q000502:physiology; D013550:Swimming / Q000502:physiology
D008024:Ligands; D017480:Receptors, sigma; D000547:Amantadine