title: Local cryoglobulin deposition in primary central nervous system lymphoma.
abstract: Primary central nervous system lymphomas (PCNSLs) represent malignant non-Hodgkin's B-cell lymphomas confined to the central nervous system. Recent years have brought a dramatic increase in the frequency of PCNSL in the immunocompromised and immunocompetent populations. Cryoglobulins are cold-precipitable immunoglobulins associated with a number of infectious, autoimmune, and neoplastic disorders. Although it is known that patients with hematologic malignancies (eg, B-cell lymphomas, chronic lymphocytic leukemia, plasma cell dyscrasias) may have cryoglobulinemias and cryoglobulin deposition in several organs (eg, kidney, liver skin, blood vessels, peripheral nervous system), PCNSL associated with cryoglobulin deposition has not been previously described. This report demonstrates localized cryoglobulin deposition within the tumor bed in an immunocompetent patient with PCNSL.
authors.affiliation: Department of Neurosurgery, Baylor College of Medicine and Texas Children's Hospital, Houston, 77030, USA.
authors.forename: Paisit
authors.initials: P
authors.lastname: Paueksakon
authors.forename: Mark
authors.initials: M
authors.lastname: Shaya
authors.forename: Richard
authors.initials: R
authors.lastname: Harper
authors.forename: John
authors.initials: J
authors.lastname: Hicks
authors.forename: Luan
authors.initials: L
authors.lastname: Truong
authors.forename: J Clay
authors.initials: JC
authors.lastname: Goodman
authors.forename: Suzanne Z
authors.initials: SZ
authors.lastname: Powell
mesh_terms: D000328:Adult; D000927:Anticonvulsants; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D002467:Cell Nucleus / Q000648:ultrastructure; D017024:Chemotherapy, Adjuvant; D003450:Cryoglobulins / Q000378:metabolism*; D003907:Dexamethasone / Q000627:therapeutic use; D006801:Humans; D016393:Lymphoma, B-Cell / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D015388:Organelles / Q000648:ultrastructure; D010672:Phenytoin / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor; D003450:Cryoglobulins; D010672:Phenytoin; D003907:Dexamethasone