A comparison of electron-transfer rates of ferrocenoyl-linked DNA.
Electron transfer (ET) through two configurations of double-stranded (ds)-DNA was investigated by the attachment of a ferrocenoyl (Fc)-labeled and thiol-labeled DNA to Au electrodes. The first configuration positions the Fc moiety on the same strand as the thiolate, whereas the second configuration positions the Fc group on the complementary strand. The subtle difference in structure leads to a difference in E0' values (29 mV) and in ET rate constants (25 vs 115 s-1). The results have led to a further understanding of electron transfer in ds-DNA, and several models of ET are proposed.
Long
Yi-Tao
YT
Department of Biochemistry, University of Saskatchewan, 107 Wiggins Road, Saskatoon, S7N 5E5, Canada.
Li
Chen-Zhong
CZ
Sutherland
Todd C
TC
Chahma
M'hamed
M
Lee
Jeremy S
JS
Kraatz
Heinz-Bernhard
HB
D004247:DNA / Q000737:chemistry*; D004583:Electrons; D005296:Ferrous Compounds / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D007700:Kinetics; D000075163:Metallocenes; D009690:Nucleic Acid Conformation; D010084:Oxidation-Reduction; D013499:Surface Properties; D013816:Thermodynamics
D005296:Ferrous Compounds; D000075163:Metallocenes; D006046:Gold; D004247:DNA; C004998:ferrocene