title: The T111I mutation in the EL gene modulates the impact of dietary fat on the HDL profile in women.
abstract: The objective of the present study was to examine the impact of the T111I missense mutation in exon 3 of the endothelial lipase (EL) gene on HDL and its potential interaction effect with dietary fat. The study sample included 281 women and 216 men aged between 17 and 76 years from the Québec Family Study. Plasma HDL3-C levels of I111I homozygote women were higher compared with those of women carrying the wild-type allele (P = 0.03). These differences were not attenuated when adjusted for levels of obesity and were not observed among men. Dietary PUFA interacted with the T111I mutation to modulate apolipoprotein A-I (apoA-I) and HDL3-C levels among women. Specifically, a diet rich in PUFA was associated with increased apoA-I levels among women carriers of the I111 allele and with decreased apoA-I among women homozygotes for the wild-type allele (P = 0.002). A similar interaction was observed with plasma HDL3-C levels (P = 0.003). These interactions were not observed among men. In conclusion, the EL T111I mutation appears to have a modest effect on plasma HDL levels. The gene-diet interaction among women, however, suggests that the T111I missense mutation may confer protection against the lowering effect of a high dietary PUFA intake on plasma apoA-I and HDL3-C levels.
authors.affiliation: Nutraceuticals and Functional Foods Institute, Pavillon Paul-Comtois, Office 2423, Laval University, Québec G1K 7P4, Canada.
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Paradis
authors.forename: Patrick
authors.initials: P
authors.lastname: Couture
authors.forename: Yohan
authors.initials: Y
authors.lastname: Bosse
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Despres
authors.forename: Louis
authors.initials: L
authors.lastname: Perusse
authors.forename: Claude
authors.initials: C
authors.lastname: Bouchard
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Vohl
authors.forename: Benoit
authors.initials: B
authors.lastname: Lamarche
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D016632:Apolipoprotein A-I / Q000097:blood / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D002149:Energy Intake; D005091:Exons; D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008049:Lipase / Q000235:genetics*; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense / Q000235:genetics*; D010641:Phenotype; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D004041:Dietary Fats; D014280:Triglycerides; C410382:LIPG protein, human; D008049:Lipase; D008071:Lipoprotein Lipase