Evaluation of in vitro antifungal activity of N-benzylsalicylamide derivatives.
A series of 65 derivatives of N-benzylsalicylamide was tested against eight potentially human pathogenic fungi by microdilution broth method modified according to M27-A standard. The majority of these compounds showed only weak in vitro antifungal activity. The most significant effect was observed against filamentous fungi Trichophyton mentagrophytes, Absidia corymbifera, and Aspergillus fumigatus while yeasts, in general, were less susceptible. N-(4'-Chlorobenzyl) salicylamides, N-(3',4'-dichlorobenzyl)-salicylamides, and partially N-benzylsalicylamides exhibited relatively high in vitro antifungal activity. The most efficient derivatives had MIC < or = 7.8 mumol/L against T. mentagrophytes. Regression analysis suggested an indirect relationship between MIC values and lipophilicity (log P).
Kubanová
P
P
Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, Czechia. kubanova@faf.cuni.cz
Buchta
V
V
Perina
M
M
Waisser
K
K
Pour
M
M
D000935:Antifungal Agents / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects*; D012457:Salicylamides / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D001593:Benzyl Compounds; D012457:Salicylamides