[Effects of isoflavone (ISO) on advanced glycosylation end products (AGEs) in aortae and serum levels of lipid peroxide in ovariectomized rats].
OBJECTIVE
To investigate effects of isoflavone(ISO) on advanced glycosylation end products (AGEs) and lipid peroxide of ovariectomized rats.


METHODS
Rats were randomly divided into sham group (Sham), ovariectomized group (OVX) and OVX + ISO group. Rats were ovariectomized, And two weeks later, OVX + ISO group were treated with ISO. Levels of aortic AGEs, lipids and serum lipid peroxide were detected after 13 weeks of treatment.


RESULTS
The aortic AGEs, serum triglycerides (TG), oxidated-LDL (OX-LDL) and malondialdehyde (MDA) of the OVX group were higher (P < 0.01, P < 0.05, P < 0.05 and P < 0.01, respectively) and the levels of high density lipoprotein-cholesterol (HDL-C), apolipoproptein A I (apo-AI) and activity of superoxide dismutase (SOD) were lower (P < 0.01, all) than that of the sham group. ISO not only reduced the concentration of aortic AGEs, serum OX-LDL, TC and MDA (P < 0.01, P < 0.05, P < 0.05 and P < 0.05 respectively), but also increased concentration of serum HDL-C, apo-A I and SOD activity (P < 0.01, all).


CONCLUSIONS
ISO could decrease aortic AGEs, serum MDA and OX-LDL, enhance SOD activity and adjust serum lipids, therefore it maybe helpful to cardiovascular system.
Ge
Xizhen
X
Institute of Integrated Chinese Traditional and Western Medicine, Hebei Medical University, Shijiazhuang 050017.
Kong
Dejuan
D
Liu
Kun
K
Li
En
E
D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism; D001161:Arteriosclerosis / Q000517:prevention & control; D005260:Female; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000097:blood*; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013025:Glycine max / Q000737:chemistry*
D017127:Glycation End Products, Advanced; D007529:Isoflavones; D008054:Lipid Peroxides