[An epidemiological study on factors affecting serum thyroglobulin levels].
OBJECTIVE
To investigate the effects of several factors affecting serum thyroglobulin (TG) levels among people aged 14 or more.


METHODS
We selected Panshan with median urinary iodine (MUI) 83.45 micro g/L as a deficient iodine intake community, Zhangwu with MUI 242.85 micro g/L as a sufficient iodine intake community and Huanghua with MUI 650.87 micro g/L as an excessive iodine intake community. Serum TG and thyroid stimulating hormone (TSH) were measured in 3,335 subjects whose thyroglobulin antibody (TGAb) were negative and thyroid volume were examined using B-ultrasound.


RESULTS
In the population with MUI of 80 - 650 micro g/L, serum TG levels presented a "V" curve. An elevated serum TG was found in both the communities with deficient iodine intake and excessive iodine intake. The same trend was shown in the groups with different levels of serum TSH. An elevated serum TG was found in both the groups of TSH < 0.3 mU/L and TSH > 4.8 mU/L. The serum TG levels was positively correlated with thyroid volume and was higher in female subjects than in male. An increased serum TG was found in subjects of aged 50 in the community with deficient iodine intake.


CONCLUSIONS
Serum TG level is affected by gender, amount of iodine intake, serum TSH level and thyroid volume.
Li
Chen-yang
CY
Department of Endocrinology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
Guan
Hai-xia
HX
Teng
Wei-ping
WP
Shan
Zhong-yan
ZY
Jin
Ying
Y
Teng
Xiao-chun
XC
Hu
Feng-nan
FN
Yang
Fan
F
Gao
Tian-shu
TS
Chen
Wei
W
Shi
Xiao-guang
XG
Man
Na
N
Tong
Ya-jie
YJ
Guo
Xiu-juan
XJ
Wang
Zhan-yi
ZY
Yang
Shi-ming
SM
He
Li
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007455:Iodine / Q000008:administration & dosage* / Q000172:deficiency / Q000506:poisoning; D008297:Male; D008875:Middle Aged; D012424:Rural Population; D012737:Sex Factors; D013954:Thyroglobulin / Q000097:blood*; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013972:Thyrotropin / Q000097:blood; D014463:Ultrasonography
D013972:Thyrotropin; D013954:Thyroglobulin; D007455:Iodine