[Proliferating cell nuclear antigen expression in recurrent aphthous ulcer and its significance].
OBJECTIVE
To explore the expression changes of proliferating cell nuclear antigen (PCNA) in oral normal mucosa and recurrent aphthous ulcers(RAU).


METHODS
The expression intensity and distribution of PCNA were examined with immunohistochemistry method in 15 cases of recurrent oral aphthous and normal oral mucosa.


RESULTS
In RAU, there was large amount of inflamed cells. In normal oral mucosa, the expression intensity of PCNA was significant higher than that in oral aphthous (P<0.05).


CONCLUSIONS
The inhibition of epidermal cells proliferation in RAU may be one of the mechanisms which one involved in RAU formation.
Sun
Peng
P
Department of Stomatology, 304th Hospital of People's Liberation Army, Beijing 100037, China.
Fu
Xiao-bing
XB
Chen
Wei
W
Zhang
Jian-qiang
JQ
Yan
Ying
Y
D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009061:Mouth Mucosa / Q000378:metabolism* / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000378:metabolism* / Q000473:pathology
D018809:Proliferating Cell Nuclear Antigen