title: [A case of advanced gastric cancer with bone metastases and DIC responding to oral administration of TS-1].
abstract: The patient was a 71-year-old man whose chief complaints were staggering and fatigue. As a result of various examinations, he was diagnosed with advanced gastric cancer, Borrmann 3, with disseminated intravascular coagulation (DIC) and bone metastases. The DIC was treated with oral administration of TS-1 (120 mg/day). Furthermore, both the primary gastric tumor and metastatic bone lesions were reduced in size by the treatment with TS-1. TS-1 appears to be an effective therapeutic agent for advanced gastric cancer with DIC or bone metastases.
authors.affiliation: First Dept. of Internal Medicine, Kyoto Prefectural University of Medicine.
authors.forename: Tatsushi
authors.initials: T
authors.lastname: Omatsu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ichikawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kawahito
authors.forename: Eiji
authors.initials: E
authors.lastname: Ashihara
authors.forename: Aihiro
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kadoya
authors.forename: Toru
authors.initials: T
authors.lastname: Takegami
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Takanashi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naito
authors.forename: Norimasa
authors.initials: N
authors.lastname: Yoshida
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sugino
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yoshikawa
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary*; D018279:Carcinoma, Signet Ring Cell / Q000188:drug therapy* / Q000556:secondary*; D004211:Disseminated Intravascular Coagulation / Q000150:complications / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D006801:Humans; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage*; D011725:Pyridines / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005641:Tegafur / Q000008:administration & dosage*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid