title: A facile solid phase synthesis of tetramic acid.
abstract: The condensation of N-acylated amino acids with polymer-supported cyclic malonic acid ester was carried out in the presence of DCC/DMAP. The cyclisation of the intermediate resin, by heating in an organic solvent, gave the N-protected tetramic acid derivatives in good yields and high purity.
authors.affiliation: Department of Chemistry, Zhejiang University, Campus Xixi, Hangzhou, 310028, People's Republic of China.
authors.forename: Zhanxiang
authors.initials: Z
authors.lastname: Liu
authors.forename: Xiuxiu
authors.initials: X
authors.lastname: Ruan
authors.forename: Xian
authors.initials: X
authors.lastname: Huang
mesh_terms: D000215:Acylation; D000596:Amino Acids / Q000138:chemical synthesis; D007202:Indicators and Reagents; D008314:Malonates / Q000737:chemistry; D011760:Pyrrolidinones / Q000138:chemical synthesis*; D012997:Solvents; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000596:Amino Acids; D007202:Indicators and Reagents; D008314:Malonates; D011760:Pyrrolidinones; D012997:Solvents; C009435:tetramic acid; C030290:malonic acid