D-Serine alleviates retrograde amnesia of a visual discrimination task in rats with a lesion of the perirhinal cortex.
D-Serine has been suggested to be a potent endogenous glycine-site agonist on the N-methyl-D-aspartate receptor, thereby having a potential role in the process of learning and memory. In rats, perirhinal cortex (PC) constitutes a particularly important structure for mnemonic processing, and damage to this area induces both anterograde and retrograde amnesia. In the present work, we show that intraperitoneal administration of 1000 mg/kg D-serine immediately after bilateral lesion of PC produced complete restoration of retrograde memory in rats, measured by a visual brightness discrimination task, while a higher dose (3000 mg/kg) did not show any reliable effect. Uptake of the drug into the brain was confirmed using high performance liquid chromatography (HPLC).
Andersen
Jannike M
JM
Norwegian Defence Research Establishment, Division for Protection and Material, N-2027, Kjeller, Norway. jannike.andersen@ffi.no
Fonnum
Frode
F
Myhrer
Trond
T
D000648:Amnesia, Retrograde / Q000188:drug therapy*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004193:Discrimination Learning / Q000187:drug effects*; D018728:Entorhinal Cortex / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D010775:Photic Stimulation; D051381:Rats; D017208:Rats, Wistar; D012694:Serine / Q000494:pharmacology*
D012694:Serine