title: Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis.
abstract: Children with acute otitis media underwent tympanocentesis and were given a single dose of 30 mg of azithromycin/kg of body weight. At day 28, the overall clinical cure rate was 206 of 242 (85%). Clinical cure rates for patients infected with Streptococcus pneumoniae (67 of 76; 88%) and Haemophilus influenzae (28 of 44; 64%) were consistent with historical rates for the 5-day dosing regimen.
authors.affiliation: Pfizer Global Research & Development, New London, Connecticut 06320, USA. michael_w_dunne@groton.pfizer.com
authors.forename: Michael W
authors.initials: MW
authors.lastname: Dunne
authors.forename: Chandra
authors.initials: C
authors.lastname: Khurana
authors.forename: Adriano Arguedas
authors.initials: AA
authors.lastname: Mohs
authors.forename: Adib
authors.initials: A
authors.lastname: Rodriguez
authors.forename: Antonio
authors.initials: A
authors.lastname: Arrieta
authors.forename: Samuel
authors.initials: S
authors.lastname: McLinn
authors.forename: Judy A
authors.initials: JA
authors.lastname: Krogstad
authors.forename: Mark
authors.initials: M
authors.lastname: Blatter
authors.forename: Richard
authors.initials: R
authors.lastname: Schwartz
authors.forename: Sergio L
authors.initials: SL
authors.lastname: Vargas
authors.forename: Paz
authors.initials: P
authors.lastname: Emparanza
authors.forename: Pilar
authors.initials: P
authors.lastname: Fernandez
authors.forename: Willis M
authors.initials: WM
authors.lastname: Gooch
authors.forename: Mary
authors.initials: M
authors.lastname: Aspin
authors.forename: John
authors.initials: J
authors.lastname: Podgore
authors.forename: Irmeli
authors.initials: I
authors.lastname: Roine
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Blumer
authors.forename: Garth D
authors.initials: GD
authors.lastname: Ehrlich
authors.forename: Jean
authors.initials: J
authors.lastname: Chow
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017963:Azithromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004322:Drainage; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010033:Otitis Media / Q000188:drug therapy / Q000382:microbiology / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin