Rhodium-catalyzed enantioselective diboration of simple alkenes.
Enantioselective catalytic reactions that operate directly on inexpensive unactivated alkenes are extraordinarily useful for the preparation of chiral organic building blocks and new materials. While a number of such processes have been developed, our ability to meet the intensifying demand for inexpensive stereochemically complex materials will require a significant expansion of practical catalytic asymmetric reaction methodology. In this regard, the rhodium-catalyzed enantioselective diboration reaction has been developed in order to address a number of extant problems in catalytic alkene transformation simultaneously. This process provides an enantiomerically enriched reactive dimetalated intermediate which can be converted to a variety of difunctional reaction products.
Morgan
Jeremy B
JB
Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.
Miller
Steven P
SP
Morken
James P
JP
D000438:Alcohols / Q000138:chemical synthesis*; D000475:Alkenes / Q000737:chemistry*; D001880:Boranes / Q000737:chemistry*; D002384:Catalysis; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D000475:Alkenes; D001880:Boranes; D012238:Rhodium