title: Irbesartan-associated persistent edema of the eyelids, face, and neck.
abstract: Irbesartan, an angiotensin II receptor antagonist (AIIRA), is an antihypertensive agent that inhibits the activity of angiotensin II by selectively binding to angiotensin II type 1 (AT1) receptors. The new onset of sustained periorbital, facial, and neck edema following the initiation of irbesartan therapy is described in a hypertensive 52-year-old woman. The patient's edema was not life threatening, remained unchanged following discontinuation of the medication, and persisted when treatment with the drug was subsequently reinstituted. Facial edema is a very uncommon adverse event that may occur in patients receiving irbesartan.
authors.affiliation: University of Houston Health Center, Department of Dermatology, University of Texas-Houston Medical School, Houston, Texas, USA. mitehead@aol.com
authors.forename: Philip R
authors.initials: PR
authors.lastname: Cohen
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects*; D001713:Biphenyl Compounds / Q000009:adverse effects*; D004487:Edema / Q000139:chemically induced*; D005145:Face; D005260:Female; D006801:Humans; D000077405:Irbesartan; D008875:Middle Aged; D013777:Tetrazoles / Q000009:adverse effects*
chemical_list: D000959:Antihypertensive Agents; D001713:Biphenyl Compounds; D013777:Tetrazoles; D000077405:Irbesartan