Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone.
Pneumolysin, a virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities, occurs at concentrations from 0.85 to 180 ng/ml in cerebrospinal fluid (CSF) of meningitis patients. In pneumococcal cultures and in a rabbit meningitis model, the concentrations of pneumolysin in supernatant and CSF were lower after addition of nonbacteriolytic bactericidal antibiotics (rifampin and clindamycin) than after incubation with ceftriaxone.
Spreer
Annette
A
Department of Neurology, University of Göttingen, Göttingen, Germany.
Kerstan
Holger
H
Böttcher
Tobias
T
Gerber
Joachim
J
Siemer
Alexander
A
Zysk
Gregor
G
Mitchell
Timothy J
TJ
Eiffert
Helmut
H
Nau
Roland
R
D000328:Adult; D000368:Aged; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins; D002443:Ceftriaxone / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D002675:Child, Preschool; D015169:Colony Count, Microbial; D003470:Culture Media; D003864:Depression, Chemical; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D008297:Male; D008586:Meningitis, Pneumococcal / Q000134:cerebrospinal fluid / Q000378:metabolism* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011817:Rabbits; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000378:metabolism*; D013301:Streptolysins / Q000134:cerebrospinal fluid / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002511:Cephalosporins; D003470:Culture Media; D013301:Streptolysins; C032290:plY protein, Streptococcus pneumoniae; D002443:Ceftriaxone