title: A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila.
abstract: Nucleotide sequence analysis of an approximately 80-kb genomic region revealed an approximately 65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system, mobile genetic elements, and known virulence factors. Comparative studies with other Legionella pneumophila strains and serogroups indicated that this approximately 65-kb locus is unique to L. pneumophila serogroup 1 Philadelphia-1 strains.
authors.affiliation: Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7.
authors.forename: Ann Karen C
authors.initials: AK
authors.lastname: Brassinga
authors.forename: Margot F
authors.initials: MF
authors.lastname: Hiltz
authors.forename: Gary R
authors.initials: GR
authors.lastname: Sisson
authors.forename: Michael G
authors.initials: MG
authors.lastname: Morash
authors.forename: Nathan
authors.initials: N
authors.lastname: Hill
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Garduno
authors.forename: Paul H
authors.initials: PH
authors.lastname: Edelstein
authors.forename: Rafael A
authors.initials: RA
authors.lastname: Garduno
authors.forename: Paul S
authors.initials: PS
authors.lastname: Hoffman
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics*; D002876:Chromosomes, Bacterial / Q000235:genetics*; D016000:Cluster Analysis; D006801:Humans; D016952:Legionella pneumophila / Q000235:genetics* / Q000472:pathogenicity*; D008969:Molecular Sequence Data; D005810:Multigene Family; D014774:Virulence
chemical_list: D001426:Bacterial Proteins