title: Depression and trail making test scores in a sample of cocaine abusers.
abstract: Depression effects on the Trail Making test (TMT), a test often used for screening cognitive impairments, were examined in a sample of cocaine abusers in drug abuse treatment programs. A mixed race sample of 4299 subjects was drawn from electronic files of data from the Drug Abuse Treatment Outcome Study (DATOS). DATOS was a naturalistic, prospective cohort study that collected data from 1991-1993 in 96 programs in 11 cities in the United States. Data were analyzed to determine the effects of depression on the TMT scores A and B, and also derived indices created by adding, subtracting, multiplying, and dividing parts A and B of the TMT in this large treatment sample of cocaine abusers. The variables of sex, age, ethnicity, and education were included in analyses to control for demographic effects. The TMT part A and the difference score were the least sensitive TMT scores to the effects of depression but all TMT R-squares were quite small.
authors.affiliation: Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA. drmachorton@hotmail.com
authors.forename: Arthur MacNeill
authors.initials: AM
authors.lastname: Horton
authors.forename: Charles
authors.initials: C
authors.lastname: Roberts
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D003042:Cocaine; D019970:Cocaine-Related Disorders / Q000150:complications / Q000503:physiopathology* / Q000523:psychology*; D003072:Cognition Disorders / Q000139:chemically induced; D003863:Depression / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014145:Trail Making Test
chemical_list: D003042:Cocaine