title: Herpes simplex encephalitis relapses in children: differentiation of two neurologic entities.
abstract: Relapses of herpes simplex encephalitis (HSE) occurring after the completion of antiviral treatment have been reported repeatedly in children. The authors report data on six children who had at least one relapse of HSE. Two different mechanisms may account for these relapses, including viral replication or an immuno-inflammatory process, with different therapeutic attitudes. Relapses with viral replication may reveal host susceptibility to herpes simplex virus infection.
authors.affiliation: Department of Pediatric Neurology, Hôpital Saint Vincent de Paul, Paris, France.
authors.forename: X
authors.initials: X
authors.lastname: De Tiège
authors.forename: F
authors.initials: F
authors.lastname: Rozenberg
authors.forename: V
authors.initials: V
authors.lastname: Des Portes
authors.forename: J B
authors.initials: JB
authors.lastname: Lobut
authors.forename: P
authors.initials: P
authors.lastname: Lebon
authors.forename: G
authors.initials: G
authors.lastname: Ponsot
authors.forename: B
authors.initials: B
authors.lastname: Héron
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D000293:Adolescent; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D020803:Encephalitis, Herpes Simplex / Q000145:classification* / Q000150:complications / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir