Suzuki cross-coupling approaches to the synthesis of bioactive 3-substituted and 5-substituted-4-methoxy-6-methyl-2-pyrones.
Suzuki cross-coupling has been used to access a wide range of 3- and 5-substituted 2-pyrones, which show remarkable inhibitory activity against bacteria, yeasts and fungi. 3-Octenyl and 5-octenyl 2-pyrones inhibit human ovarium carcinoma (A2780) and human chronic myelogenous leukaemia (K562) cell lines at the micromolar level.
Marrison
Lester R
LR
Department of Chemistry and Materials, John Dalton Building, The Manchester Metropolitan University, Chester Street, Manchester M1 5GD, UK.
Dickinson
Julia M
JM
Fairlamb
Ian J S
IJ
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001897:Boronic Acids / Q000737:chemistry; D045744:Cell Line, Tumor / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008956:Models, Chemical; D011753:Pyrones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001897:Boronic Acids; D011753:Pyrones