title: Effects of rotation on the P13 mid-latency auditory evoked potential in rat.
abstract: The P13 mid-latency auditory evoked potential in Rat is a sleep state-dependent response thought to be equivalent to the human P50 potential, a measure of the output of the reticular activating system. The amplitude of these potentials can be considered a measure of level of arousal, while, using a paired stimulus paradigm, the degree of habituation of the responses also can be assessed. Different durations of rotation were found to reduce the amplitude of the P13 potential, which recovered in a duration-dependent manner. Different durations of rotation led to decreases in habituation of the P13 potential again in a duration-dependent manner. These results suggest that rotation may affect the level of arousal as well as habituation to repetitive sensory inputs. Such effects could be interpreted to imply the presence, following rotation of sufficient duration, of a deficit in sensory gating, or distractibility, and are relevant for the study of the effects of space motion sickness.
authors.affiliation: Department of Anatomy and Neurobiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Homma
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Homma
authors.forename: Luis
authors.initials: L
authors.lastname: Teneud
authors.forename: Robert D
authors.initials: RD
authors.lastname: Skinner
authors.forename: John
authors.initials: J
authors.lastname: Dornhoffer
authors.forename: D Keith
authors.initials: DK
authors.lastname: Williams
authors.forename: Edgar
authors.initials: E
authors.lastname: Garcia-Rill
mesh_terms: D000818:Animals; D001143:Arousal / Q000502:physiology; D004569:Electroencephalography; D004576:Electromyography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006185:Habituation, Psychophysiologic / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D012154:Reticular Formation / Q000502:physiology*; D012399:Rotation