Oxidative damage to DNA and aging.
Oxidative damage to DNA increases with age in several tissues and animal models, and mitochondrial DNA has a higher level of oxidative damage than nuclear DNA. Dietary restriction extends lifespan and is associated with reduced levels of damage to mitochondrial and nuclear DNA. The effect of exercise on DNA damage appears to be related to the intensity of the exercise.
Van Remmen
Holly
H
Department of Physiology, University of Texas Health Science Center at San Antonio, USA. vanremmen@uthscsa.edu
Hamilton
Michelle L
ML
Richardson
A
A
D000375:Aging; D000818:Animals; D004249:DNA Damage; D004272:DNA, Mitochondrial; D004032:Diet; D015444:Exercise; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress
D004272:DNA, Mitochondrial