Comparison of subject-reported allergy versus skin test results in a common cold trial.
BACKGROUND
Few studies have examined the relationship between subject-reported allergy and results of allergy skin testing in large unselected or unbiased cohorts. The objective of this study was to compare the results of self-reported allergy via verbal questioning with the results of allergy skin testing by the puncture method in 237 healthy adult subjects enrolled in a common cold study.


METHODS
On enrollment, all subjects were verbally asked if they had a history of allergy and then underwent puncture skin testing to 19 relevant aeroallergens, as well as appropriate positive and negative controls. A skin test was considered positive if its wheal diameter was at least 3 mm larger than that obtained with the negative control.


RESULTS
Forty-eight (20%) subjects reported a history of allergy and 124 (52%) subjects had at least one positive skin test response. A history of allergy was reported in 40 (32%) of the skin test-positive subjects and 8 (7%) of the skin test-negative subjects. At least one positive skin test response was found in 40 (83%) of those subjects reporting a history of allergy and 84 (44%) of those subjects denying a history of allergy.


CONCLUSIONS
These data indicate that there is a relatively poor correlation between self-reported history of allergy and skin test results in subjects enrolled in a common cold study. These results have implications in both clinical practice and research settings.
Krahnke
Jason S
JS
Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Gentile
Deborah A
DA
Cordoro
Kelly M
KM
Angelini
Betty L
BL
Cohen
Sheldon A
SA
Doyle
William J
WJ
Skoner
David P
DP
D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D007428:Intradermal Tests; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D011795:Surveys and Questionnaires