Controlled release of vancomycin from freeze-dried chitosan salts coated with different fatty acids by spray-drying.
The aim of this study was to describe a controlled drug release system based on chitosan salts for vancomycin hydrochloride delivery. Chitosan aspartate (CH-Asp), chitosan glutamate (CH-Glu) and chitosan hydrochloride (CH-HCl) were prepared by freeze-drying and coated with stearic, palmitic, myristic and lauric acids by spray-drying technique. Vancomycin hydrochloride was used as a peptidic model drug whose sustained release should minimize its inactivation in the upper part of the gastrointestinal tract. This study evaluated, in vitro, the influence of chitosan salts on the release behaviour of vancomycin hydrochloride from the freeze-dried and spray-dried systems at pH 2.0 and 7.4.
Cerchiara
T
T
University of Bologna, Department of Pharmaceutical Sciences, Via S. Donato 19/2, 40127 Bologna, Italy.
Luppi
B
B
Bigucci
F
F
Petrachi
M
M
Orienti
I
I
Zecchi
V
V
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001682:Biological Availability; D001704:Biopolymers; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry*; D048271:Chitosan; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D005227:Fatty Acids / Q000737:chemistry*; D005612:Freeze Drying; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008863:Microspheres; D014640:Vancomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014783:Viscosity
D000900:Anti-Bacterial Agents; D001704:Biopolymers; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005227:Fatty Acids; D002686:Chitin; D014640:Vancomycin; D048271:Chitosan