Immune reconstitution in HIV infection and its relationship to cancer.
HIV infection results in formidable immune dysfunction, widely affecting the immune system, but typified by T lymphopenia. This dysfunction includes a perturbed immune response to several persistent viruses that have a propensity to cause tumors. Effective control of HIV replication by highly active antiretroviral therapy (HAART) results in regeneration of the damaged immune system, and recent advances have allowed this immune reconstitution to be better defined. This article describes the immunodeficiency caused by HIV and the response of the immune system to HAART, with specific reference to the immune response to cancers associated with HIV infection.
Robertson
Paul
P
AIDS Research Center, Massachusetts General Hospital, Harvard Medical School 149, 13th Street, Room 5212, Boston, MA 02109, USA.
Scadden
David T
DT
D015658:HIV Infections / Q000150:complications / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007107:Immune System / Q000473:pathology*; D016483:Lymphoma, AIDS-Related / Q000209:etiology / Q000276:immunology / Q000628:therapy; D009369:Neoplasms / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000276:immunology / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology