title: Small vessel vasculitis limited to pleuropulmonary manifestations, possibly induced by endotoxin.
abstract: OBJECTIVE
  We investigated a rare case of small vessel vasculitis (SVV) limited to pleuropulmonary manifestations, possibly induced by endotoxin, to determine the activation of immuno-mediated cells and endothelia in the pleuropulmonary circulation.
  
  
  RESULTS
  A 44-year-old man with a high fever was X-rayed, revealing bilateral pleural effusion and atelectasis in the chest. His laboratory data were within normal limits except for a high white blood cell count and a high C-reactive protein level. Autoantibodies including anti-neutrophil cytoplasmic antibody were negative. Endotoxin was detected in his sera, but repeated cultures of sputa, urine, blood and the pleural effusion were negative for bacteria. Video-assisted thoracic surgery was performed and lung and parietal pleura specimens were obtained. Histology showed arterioles or small arteries infiltrated by monocytes or neutrophils with fibrinoid necrosis and acute or chronic venulitis. A diagnosis of SVV in the lung and pleura was made. Immunohistochemistry revealed that interleukin (IL)-1beta was expressed in monocytes and vascular cell adhesion molecule (VCAM)-1 on endothelial cells in the vasculitic lesions in the lung.
  
  
  CONCLUSIONS
  Endotoxin possibly induced the inflammation in this apparently unique case of pleuropulmonary small vessel vasculitis. Immunohistochemistry revealed the expression of IL-1beta and VCAM-1 which may have caused activation of monocytes and endothelial cells within the vasculitic lesions.
authors.affiliation: Department of Pathology I, School of Medicine, Juntendo University, Tokyo, Japan. kumasaka@med.juntendo.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kumasaka
authors.forename: K
authors.initials: K
authors.lastname: Mitani
authors.forename: H
authors.initials: H
authors.lastname: Izumi
authors.forename: H
authors.initials: H
authors.lastname: Miyamoto
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuchi
authors.forename: K
authors.initials: K
authors.lastname: Suda
mesh_terms: D000328:Adult; D001160:Arterioles / Q000473:pathology*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D004731:Endotoxins; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D008297:Male; D010994:Pleura / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D010996:Pleural Effusion / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism; D014657:Vasculitis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*
chemical_list: D004731:Endotoxins; D005938:Glucocorticoids; D007375:Interleukin-1; D019010:Vascular Cell Adhesion Molecule-1