Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease.
One of the pathological characteristics of Alzheimer's disease (AD) is the formation of dystrophic neurites accompanied by aberrant neuronal sprouting. Although a number of studies have focussed on the formation of amyloid plaques and neurofibrillary tangles, the mechanism of neuronal sprouting in AD is not fully understood. The protein levels of neural Wiskott-Aldrich syndrome protein (N-WASP), WASP interacting SH3 protein (WISH) and WASP family verprolin-homologous protein (WAVE) were significantly increased in AD brains. In addition, N-WASP, WISH and WAVE were co-localized with filamentous actin in abnormal dendrite-like processes sprouting from staurosporine-treated human SH-SY5Y cells. These results suggest that N-WASP, WISH and WAVE may participate in the neurodegenerative aberrant sprouting in AD neurons.
Kitamura
Yoshihisa
Y
Department of Neurobiology, Kyoto Pharmaceutical University, 607-8412, Kyoto, Japan.
Tsuchiya
Daiju
D
Takata
Kazuyuki
K
Shibagaki
Keiichi
K
Taniguchi
Takashi
T
Smith
Mark A
MA
Perry
George
G
Miki
Hiroaki
H
Takenawa
Tadaomi
T
Shimohama
Shun
S
D048868:Adaptor Proteins, Signal Transducing; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure; D002352:Carrier Proteins / Q000378:metabolism*; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D008840:Microfilament Proteins / Q000378:metabolism*; D018613:Microscopy, Confocal; D009124:Muscle Proteins; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism* / Q000648:ultrastructure; D019311:Staurosporine / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014923:Wiskott-Aldrich Syndrome / Q000378:metabolism*; D051300:Wiskott-Aldrich Syndrome Protein Family; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D008840:Microfilament Proteins; D009124:Muscle Proteins; C486062:NCKIPSD protein, human; D009419:Nerve Tissue Proteins; C495771:WASL protein, human; D051300:Wiskott-Aldrich Syndrome Protein Family; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal; D019311:Staurosporine