title: Goodpasture-like syndrome induced by D-penicillamine in a patient with systemic sclerosis: report and review of the literature.
abstract: We report a case of Goodpasture-like syndrome developing in a patient who was treated with D-penicillamine for the diffuse form of systemic sclerosis. This unusual pulmonary-renal syndrome has been described on rare occasions in patients receiving D-penicillamine. This complication appeared to be uniformly fatal unless treated with aggressive immunotherapy. We review the cases reported to date in the literature and describe the clinical characteristics, therapy, and outcome of this group of patients.
authors.affiliation: Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5541, USA. chris.derk@mail.tju.edu
authors.forename: Chris T
authors.initials: CT
authors.lastname: Derk
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Jimenez
mesh_terms: D000368:Aged; D019867:Anti-Glomerular Basement Membrane Disease / Q000139:chemically induced* / Q000473:pathology; D018501:Antirheumatic Agents / Q000009:adverse effects*; D017809:Fatal Outcome; D005921:Glomerulonephritis / Q000139:chemically induced / Q000473:pathology; D006470:Hemorrhage / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced / Q000473:pathology; D008297:Male; D010396:Penicillamine / Q000009:adverse effects*; D013902:Radiography, Thoracic; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy*
chemical_list: D018501:Antirheumatic Agents; D010396:Penicillamine