Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1-E2-Origin DNA complex.
We have discovered a series of inhibitors of the assembly of the HPV11 E1-E2-origin DNA complex, which incorporate an indandione fused to a substituted tetrahydrofuran.
Yoakim
Christiane
C
Department of Chemistry, Boehringer Ingelheim (Canada) Ltd., 2100 Cunard Street, Laval, Québec, Canada H7S 2G5. cyoakim@lav.boehringer-ingelheim.com
Ogilvie
William W
WW
Goudreau
Nathalie
N
Naud
Julie
J
Haché
Bruno
B
O'Meara
Jeff A
JA
Cordingley
Michael G
MG
Archambault
Jacques
J
White
Peter W
PW
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004279:DNA, Viral / Q000096:biosynthesis*; D015195:Drug Design; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D027383:Papillomaviridae / Q000187:drug effects*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014764:Viral Proteins / Q000096:biosynthesis / Q000235:genetics; D019065:Virus Assembly / Q000187:drug effects
D000998:Antiviral Agents; D004279:DNA, Viral; D014764:Viral Proteins