Expression of functional markers in acute lymphoblastic leukemia.
We analyzed surface antigens, multidrug resistance (MDR) parameters (PGP, MRP, LRP), tissue infiltration parameters (CD18, CD44, VCAM, MMP2), receptors for colony stimulating factors (G-CSFr, GM-CSFr) and cell cycle parameters (Ki-67, topoisomerase IIalpha) in 86 patients with acute lymphoblastic leukemia (ALL). LRP, PGP and CD18 were associated with poor clinical outcome, and LRP expression was related with CD18, CD44 and G-CSFr. Of the cell cycle parameters, Ki-67 (+) fraction was increased in ALL with hepato-splenomegaly and extramedullary involvement. In conclusion, analysis of LRP, PGP, CD18 and Ki-67 could be helpful to predict the clinical behavior of ALL.
Oh
Eun-Jee
EJ
Department of Clinical Pathology, College of Medicine, St. Mary's Hospital, The Catholic University of Korea, 62 Youido-dong Youngdeungpo-gu, Seoul 150-713, South Korea.
Kahng
Jimin
J
Kim
Yonggoo
Y
Kim
Myungshin
M
Lim
Jihyang
J
Kang
Chang Suk
CS
Min
Woo Sung
WS
Cho
Bin
B
Lee
Ahwon
A
Lee
Kyo Young
KY
Kim
Won Il
WI
Shim
Sang In
SI
Han
Kyungja
K
D018528:ATP-Binding Cassette Transporters / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000954:Antigens, Surface / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology; D015815:Cell Adhesion Molecules; D002453:Cell Cycle; D002465:Cell Movement; D002648:Child; D002675:Child, Preschool; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques; D015999:Multivariate Analysis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011379:Prognosis; D016184:Receptors, Colony-Stimulating Factor / Q000032:analysis
D018528:ATP-Binding Cassette Transporters; D000954:Antigens, Surface; D015415:Biomarkers; D015815:Cell Adhesion Molecules; D016184:Receptors, Colony-Stimulating Factor