title: Successful treatment of rhinocerebral mucormycosis with liposomal amphotericin B and surgery in two diabetic patients with renal dysfunction.
abstract: The zygomycetes are a class of fungi that can cause a variety of infections in humans. Rhinocerebral mucormycosis is a rare disease and usually affects diabetic or immunosuppressed patients. The disease progresses rapidly and is usually fatal despite aggressive surgical and medical therapy. We report the management of two cases of rhino-sinusal and orbital mucormycosis in diabetic patients on treatment with corticosteroids, and mild renal impairment, successfully treated with a combination of aggressive surgical debridement and liposomal amphotericin B.
authors.affiliation: Department of Internal Medicine, University of Crete School of Medicine, University Hospital Heraklion, Crete, Greece. kofterid@med.uoc.gr
authors.forename: D P
authors.initials: DP
authors.lastname: Kofteridis
authors.forename: S
authors.initials: S
authors.lastname: Karabekios
authors.forename: J G
authors.initials: JG
authors.lastname: Panagiotides
authors.forename: J
authors.initials: J
authors.lastname: Bizakis
authors.forename: D
authors.initials: D
authors.lastname: Kyrmizakis
authors.forename: Z
authors.initials: Z
authors.lastname: Saridaki
authors.forename: A
authors.initials: A
authors.lastname: Gikas
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000175:diagnosis; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003646:Debridement / Q000379:methods; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009091:Mucormycosis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D009916:Orbital Diseases / Q000175:diagnosis / Q000628:therapy*; D010254:Paranasal Sinus Diseases / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B