Effects of pentoxifylline on alcohol-induced gastric injury and acid secretion in rats.
We aimed to evaluate the protective effects of pentoxifylline on alcohol-induced gastric injury, its relation with nitric oxide and prostaglandin synthesis, as well as gastric acidity in rats. Acute gastric mucosal injury was induced by intragastric infusion of 2 ml 98% alcohol. Pentoxifylline was given at 100 mg/kg intraperitoneally. Indomethacin and N(G)-nitro-L arginine were used to inhibit prostaglandin and nitric oxide synthesis, respectively. Macroscopic and microscopic gastric injuries were evaluated. Gastric pH, tissue malondialdehyde levels, oxidized and reduced glutathion (GSSG/GSH) levels, and effects of pentoxifylline on gastric acid output were measured. Pentoxifylline pretreatment significantly reduced macroscopic and microscopic gastric injury. Malondialdehyde level was lower in pentoxifylline treated rats (351.1 +/- 94.1 nmol/g vs 624.3 +/- 234.2 nmol/g). Pentoxifylline has a protective role on alcohol-induced gastric mucosal injury in rats. This effect is not related to synthesis of prostaglandins and changes in gastric acidity but does seem to be related to nitric oxide-mediated pathways. In contrast, pentoxifylline increases gastric acid output significantly.
Yönetci
Nadir
N
Department of Gastroenterology, Pamukkale University, Denizli, Turkey.
Kösekli
Mehmet Ali
MA
Ozütemiz
A Omer
AO
Karaoğlu
Ali Onder
AO
Oruç
Nevin
N
Erkuş
Muhan
M
Tanyalçin
Tijen
T
Batur
Yücel
Y
D000818:Animals; D000431:Ethanol; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D010431:Pentoxifylline / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D013272:Stomach Diseases / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control*
D020011:Protective Agents; D009569:Nitric Oxide; D000431:Ethanol; D010431:Pentoxifylline