Goal-directed, serial and synchronous activation of neurons in the primate striatum.
To study roles of cortico-basal ganglia loops in action planning, we examined interactions between the activities of simultaneously recorded neurons in the striatum of monkeys performing sequence motor tasks by cross-correlation analysis. Serial activation occurred between projection neurons in a motor sequence-dependent manner, and was in the direction of a neuron encoding an early event in the sequence to a neuron encoding the same event or later, but closer event to the reward. Synchronous activation occurred between pairs of interneurons. The serial activation seems to originate through the cortico-basal ganglia loops, because projection neurons are inhibitory. We propose that the task-dependent serial and synchronous activation of striate neurons may be a neural substrate for goal-directed planning through the basal ganglia.
Kimura
Minoru
M
Department of Physiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. mkimura@basic.kpu-m.ac.jp
Matsumoto
Naoyuki
N
Okahashi
Kenji
K
Ueda
Yasumasa
Y
Satoh
Takemasa
T
Minamimoto
Takafumi
T
Sakamoto
Masashi
M
Yamada
Hiroshi
H
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology; D003342:Corpus Striatum / Q000166:cytology / Q000502:physiology*; D004594:Electrophysiology; D006040:Goals; D000882:Haplorhini; D009043:Motor Activity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*