A kelch beta propeller featuring as a G beta structural mimic: reinventing the wheel?
New genetic and protein interaction data suggest that G protein alpha subunits may have partners with primary sequences that are quite divergent. How this is achieved may be through the adoption of similar structures, the beta propeller, by both proteins containing WD-40 repeats and kelch domains. Gettemans et al. describe results in yeast that suggest that kelch-domain proteins may serve as previously unrecognized beta subunits in the heterotrimeric G protein complex.
Gettemans
Jan
J
Department of Biochemistry, Faculty of Medicine and Health Sciences, Flanders Interuniversity Institute for Biotechnology, Ghent University, Rommelaere Institute, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium. jan.gettemans@UGent.be
Meerschaert
Kris
K
Vandekerckhove
Joel
J
De Corte
Veerle
V
D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry* / Q000502:physiology*; D020962:Heterotrimeric GTP-Binding Proteins / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D008958:Models, Molecular; D018716:Molecular Mimicry; D021122:Protein Subunits / Q000737:chemistry* / Q000502:physiology*; D013329:Structure-Activity Relationship
D002352:Carrier Proteins; D021122:Protein Subunits; D020962:Heterotrimeric GTP-Binding Proteins