[Significance of biological indicators of mercury exposure].
BACKGROUND
It was considered appropriate to update of the significance and use of the different mercury exposure indicators.


OBJECTIVE
The aim of the this paper was to correctly select biological media and sampling time and to understand the toxic kinetics of mercury for assessment of accurate biological monitoring.


RESULTS
It was confirmed that mercury in blood (B-Hg) is a good indicator of recent exposure, while urinary mercury (U-Hg) indicates current exposure when mercury reaches the renal steady state. B-Hg values are greatly influenced by fish consumption, while the variables influencing U-Hg values are amalgam fillings, commercial gamma-globulin preparations, vaccines, topical remedies, environmental pollution and hobbies, occupational exposure and, partly, fish consumption. The speciation of mercury (Hg0, Hg++, methylmercury and ethylmercury) in biological media, should provide additional and important information in evaluating mercury toxicity.


CONCLUSIONS
It was stressed that the appropriate choice of exposure indicators has to take account of the different variability factors and the characteristics of the toxic kinetics of mercury. The results of biological monitoring must be compared with references values, which are generally in the order of several micrograms/g creatinine, and limit values such as ACGIH BEI (U-Hg 35 micrograms/g creatinine and B-Hg 15 micrograms/l) or the DFG BAT (U-Hg 100 micrograms/l and B-Hg 25 micrograms/l).
Apostoli
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Cattedra di Igiene Industriale, Università degli Studi di Brescia, p.le Spedali Civili 1, 25123 Brescia.
Mangili
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Alessio
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D000818:Animals; D003404:Creatinine / Q000097:blood; D003723:Dental Amalgam; D004784:Environmental Monitoring / Q000379:methods / Q000706:statistics & numerical data; D004785:Environmental Pollutants / Q000493:pharmacokinetics; D005035:Ethylmercury Compounds / Q000493:pharmacokinetics; D005399:Fishes; D005506:Food Contamination; D006686:Hobbies; D006801:Humans; D016756:Immunoglobulins, Intravenous; D007558:Italy; D007668:Kidney / Q000378:metabolism; D008628:Mercury / Q000032:analysis* / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D008767:Methylmercury Compounds / Q000493:pharmacokinetics; D016273:Occupational Exposure; D011310:Preservatives, Pharmaceutical / Q000493:pharmacokinetics; D012015:Reference Standards
D004785:Environmental Pollutants; D005035:Ethylmercury Compounds; D016756:Immunoglobulins, Intravenous; D008767:Methylmercury Compounds; D011310:Preservatives, Pharmaceutical; D003723:Dental Amalgam; D003404:Creatinine; D008628:Mercury