Novel coumarin derivatives of heterocyclic compounds as lipid-lowering agents.
Coumarin derivatives of different heterocycles (5,7a-i, 10 and 11) were designed based on cyclisation of 2-ethoxy-3-phenylpropanoic acid and 2-benzylmalonic acid as novel lipid-lowering agents and their preliminary in vivo screening indicates 7c has moderate triglyceride-lowering activity.
Madhavan
Gurram R
GR
Discovery Chemistry, Dr. Reddy's Discovery Research, Bollarum Road, Miyapur, Hyderabad 500050, India. madhavangr@drreddys.com
Balraju
Vadla
V
Mallesham
Bejugam
B
Chakrabarti
Ranjan
R
Lohray
Vidya B
VB
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology*; D011345:Fenofibrate / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D051379:Mice; D014280:Triglycerides / Q000097:blood
D000975:Antioxidants; D003374:Coumarins; D006571:Heterocyclic Compounds; D000960:Hypolipidemic Agents; D007202:Indicators and Reagents; D014280:Triglycerides; D011345:Fenofibrate