title: [Study on the changes in endogenous oxidation agents and levels of anti-oxidation agents in patients with cerebral vascular disease].
abstract: OBJECTIVE
  To investigate serum levels of endogenous oxidation agents, anti-oxidation agents and clinical significance in the patients with cerebral vascular disease (CVD).
  
  
  METHODS
  Using biochemical methods, the levels of serum nitric oxide (NO), nitric oxide synthase (NOS), malondialdehyde (MDA) and anti-oxidants vitamin E (VitE), vitamin C (VitC), superoxide dismutase (SOD) in 49 patients with cerebral hemorrhage (CH), 65 patients with cerebral infarction(CI) and 35 patients with other nervous system diseases and 34 healthy controls were determined.
  
  
  RESULTS
  In CH and CI groups, the levels of serum NO and MDA and the activity of serum NOS were significantly higher than that of the two other groups (P<0.05 or P<0.01). On the other hand, the patients with CH and CI had lower VitE, VitC levels and SOD activity than that of the two control groups (P<0.05 or P<0.01).
  
  
  CONCLUSIONS
  These findings suggest NO and NOS plays an important role in pathogenesis of cerebral damage after CH and CI. Determination of the concentrations of NO, VitE, VitC, MDA level, and NOS and SOD activity in serum can also help judge the seriousness and the course of the disease.
authors.affiliation: Department of Neurology Qiannan Prefecture Hospital, Duyun 558000, Guizhou, China.
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Chen
authors.forename: Xiao-juan
authors.initials: XJ
authors.lastname: Liu
authors.forename: Qi-chun
authors.initials: QC
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Zeng
authors.forename: Xian-ping
authors.initials: XP
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D019001:Nitric Oxide Synthase / Q000097:blood*; D010084:Oxidation-Reduction; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D009569:Nitric Oxide; D008315:Malondialdehyde; D019001:Nitric Oxide Synthase; D001205:Ascorbic Acid