Antioxidant properties of galantamine hydrobromide.
The antioxidant properties of galantamine hydrobromide ((4alpha,6beta)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide) were studied in vitro, using luminol-dependent chemiluminescence and spectrophotometry. It was found that this compound was a scavenger of reactive oxygen species (ROS). By comparing the antioxidant effects of galantamine ((4alpha,6beta)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol), galantamine hydrobromide, narwedine (4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one), and narwedine hydrobromide it was found that the antioxidant activity depended on the enolic OH group in the molecule. The presence of a quaternary nitrogen in the compound increased the strength of the scavenging effect. It is proposed that the antioxidant properties observed in vitro may contribute to the therapeutical effect of galantamine hydrobromide on patients with brain degeneration.
Traykova
M
M
Department of Pharmacology and Toxicology, Medical Faculty, Sofia University of Medicine, 2 Zdrave Street, Sofia 1431, Bulgaria. m_traykova@mail.bg
Traykov
T
T
Hadjimitova
V
V
Krikorian
K
K
Bojadgieva
N
N
D000975:Antioxidants / Q000494:pharmacology*; D016166:Free Radical Scavengers; D005702:Galantamine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006861:Hydrogen Peroxide; D017665:Hydroxyl Radical / Q000032:analysis; D008165:Luminol; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D013481:Superoxides
D000975:Antioxidants; D016166:Free Radical Scavengers; D005702:Galantamine; D013481:Superoxides; D017665:Hydroxyl Radical; D008165:Luminol; D006861:Hydrogen Peroxide