Ubiquitinated deiodinase: not dead yet.
Originating in the thyroid, the prohormone thyroxine is converted to triiodothyronine, which is essential in brain development, growth, and metabolism. A study in this issue reveals a novel mechanism for controlling triiodothyronine production that provides the first example of enzyme activity being restored by deubiquitination.
Koenig
Ronald J
RJ
University of Michigan Medical Center, 5560 Medical Science Research Building II, 1150 W Medical Center Drive, Ann Arbor, Michigan 48109-0678, USA. rkoenig@umich.edu
D000818:Animals; D006801:Humans; D007453:Iodide Peroxidase / Q000502:physiology*; D008954:Models, Biological; D013696:Temperature; D013963:Thyroid Hormones / Q000096:biosynthesis*; D025801:Ubiquitin / Q000378:metabolism*; D000097564:Iodothyronine Deiodinase Type II
D007453:Iodide Peroxidase; D013963:Thyroid Hormones; D025801:Ubiquitin; D000097564:Iodothyronine Deiodinase Type II