title: A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents.
abstract: The aim of this review is to update current knowledge on the betulinic, ursolic and echinocystic acids and their natural and semisynthetic analogs, focussing on their cytotoxic and anti-HIV activities. Then, the last results of the authors' team on unusual semisynthetic derivatives of these triterpenoids will be presented in order to establish structure/activity relationships.
authors.affiliation: Unité MIB, JE 2244, Faculté de Pharmacie, Université de Bourgogne, 7 Bd Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France. malacd@u-bourgogne.fr
authors.forename: I
authors.initials: I
authors.lastname: Baglin
authors.forename: A-C
authors.initials: AC
authors.lastname: Mitaine-Offer
authors.forename: M
authors.initials: M
authors.lastname: Nour
authors.forename: K
authors.initials: K
authors.lastname: Tan
authors.forename: C
authors.initials: C
authors.lastname: Cavé
authors.forename: M-A
authors.initials: MA
authors.lastname: Lacaille-Dubois
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D019073:HT29 Cells; D006801:Humans; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D053978:Pentacyclic Triterpenes; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D000094062:Betulinic Acid; D000097245:Ursolic Acid
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D009828:Oleanolic Acid; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D000094062:Betulinic Acid; D000097245:Ursolic Acid; C022999:echinocystic acid