Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity.
Prenylated flavonoids containing the resorcinol moiety were isolated as tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation. Among the 12 compounds isolated, kuraridin, kurarinone and norkurarinol showed stronger inhibitory potencies (IC 50 = 1.1, 1.3 and 2.1 microM, respectively) than that of kojic acid (IC 50 = 11.3 microM), a well known tyrosinase inhibitor. Substitution of a lavandulyl or hydroxylavandulyl group at the C-8 position and a methoxy or hydroxy group at the C-5 position are essential for the inhibitory effect.
Son
Jong Keun
JK
College of Pharmacy, Yeungnam University, Kyongsan, Korea.
Park
Ji Soo
JS
Kim
Jeong Ah
JA
Kim
Youngsoo
Y
Chung
See Ryun
SR
Lee
Seung Ho
SH
D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D017368:Protein Prenylation; D011753:Pyrones / Q000494:pharmacology; D029909:Sophora
D005419:Flavonoids; D010455:Peptides; D010936:Plant Extracts; D011753:Pyrones; C011890:kojic acid; D014442:Monophenol Monooxygenase