title: Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium.
abstract: Glucagon-like peptide-1 (7-36) amide (GLP-1) has been studied as a treatment option in diabetic patients. We investigated the effect of recombinant GLP-1 infusion on hemodynamic parameters, myocardial metabolism, and infarct size during normoxic conditions as well as during ischemia and reperfusion using an open-chest porcine heart model. In the presence of rGLP-1, interstitial levels of pyruvate and lactate decreased during ischemia and reperfusion both in ischemic and non-ischemic tissue. Moreover, rGLP-1 infusion resulted in increased plasma insulin levels and decreased blood glucose levels. Neither hemodynamic variables nor the consequent infarct size were influenced by rGLP-1 infusion. We conclude that rGLP-1 altered myocardial glucose utilization during ischemia and reperfusion. It did not exert any untoward hemodynamic effects.
authors.affiliation: Department of Public Health and Clinical Medicine, Umeå University Hospital, Umeå, Sweden.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kavianipour
authors.forename: Mario R
authors.initials: MR
authors.lastname: Ehlers
authors.forename: Klas
authors.initials: K
authors.lastname: Malmberg
authors.forename: Gunnar
authors.initials: G
authors.lastname: Ronquist
authors.forename: Lars
authors.initials: L
authors.lastname: Ryden
authors.forename: Gerhard
authors.initials: G
authors.lastname: Wikström
authors.forename: Mark
authors.initials: M
authors.lastname: Gutniak
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D002319:Cardiovascular System; D005934:Glucagon; D052216:Glucagon-Like Peptide 1; D004763:Glucagon-Like Peptides; D007511:Ischemia; D019344:Lactic Acid / Q000737:chemistry*; D017551:Microdialysis; D009203:Myocardial Infarction / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D010446:Peptide Fragments / Q000737:chemistry* / Q000494:pharmacology; D011498:Protein Precursors / Q000737:chemistry; D019289:Pyruvic Acid / Q000737:chemistry*; D015427:Reperfusion Injury; D013552:Swine; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D010446:Peptide Fragments; D011498:Protein Precursors; C055453:glucagon-like peptide 1 (7-36)amide; D019344:Lactic Acid; D004763:Glucagon-Like Peptides; D019289:Pyruvic Acid; D052216:Glucagon-Like Peptide 1; D005934:Glucagon