title: A comparison of electron-transfer rates of ferrocenoyl-linked DNA.
abstract: Electron transfer (ET) through two configurations of double-stranded (ds)-DNA was investigated by the attachment of a ferrocenoyl (Fc)-labeled and thiol-labeled DNA to Au electrodes. The first configuration positions the Fc moiety on the same strand as the thiolate, whereas the second configuration positions the Fc group on the complementary strand. The subtle difference in structure leads to a difference in E0' values (29 mV) and in ET rate constants (25 vs 115 s-1). The results have led to a further understanding of electron transfer in ds-DNA, and several models of ET are proposed.
authors.affiliation: Department of Biochemistry, University of Saskatchewan, 107 Wiggins Road, Saskatoon, S7N 5E5, Canada.
authors.forename: Yi-Tao
authors.initials: YT
authors.lastname: Long
authors.forename: Chen-Zhong
authors.initials: CZ
authors.lastname: Li
authors.forename: Todd C
authors.initials: TC
authors.lastname: Sutherland
authors.forename: M'hamed
authors.initials: M
authors.lastname: Chahma
authors.forename: Jeremy S
authors.initials: JS
authors.lastname: Lee
authors.forename: Heinz-Bernhard
authors.initials: HB
authors.lastname: Kraatz
mesh_terms: D004247:DNA / Q000737:chemistry*; D004583:Electrons; D005296:Ferrous Compounds / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D007700:Kinetics; D000075163:Metallocenes; D009690:Nucleic Acid Conformation; D010084:Oxidation-Reduction; D013499:Surface Properties; D013816:Thermodynamics
chemical_list: D005296:Ferrous Compounds; D000075163:Metallocenes; D006046:Gold; D004247:DNA; C004998:ferrocene