Analysis of the urinary excretion of ifosfamide and its N-dechloroethylated metabolites in children using 31P-NMR spectroscopy.
Amounts of ifosfamide (CAS 3778-73-2) and its N-dechloroethylated metabolites excreted in the urine were measured using 31P-NMR spectroscopy in 26 cancer children treated with this drug. Strong inter-patient variation in levels of these compounds were found. These differences were independent from patients age, body surface area, and sex, the dose of the drug, suggesting genetic base of observed variations in ifosfamide metabolism.
Misiura
Konrad
K
Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lódź, Poland. kmisiura@bio.cbmm.lodz.pl
Zubowska
Małgorzata
M
Zielińska
Elzbieta
E
D000293:Adolescent; D000375:Aging / Q000378:metabolism; D018906:Antineoplastic Agents, Alkylating / Q000493:pharmacokinetics / Q000652:urine*; D001711:Biotransformation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000652:urine*; D009682:Magnetic Resonance Spectroscopy; D008297:Male
D018906:Antineoplastic Agents, Alkylating; C475964:N-dechloroethylifosfamide; D007069:Ifosfamide