title: [Sternal osteomyelitis and scrofuloderma due to BCG vaccination].
abstract: BCG vaccine has been used for nearly 100 years in the prevention of tuberculosis. The case of a 13 month-old girl vaccinated as a newborn with BCG is described as presenting a sternal mass with associated periostic erosion. The mass was resected, and histopathological examination revealed a chronic inflammatory reaction with caseous granulomas, and extension to bone and skin. PCR amplifications using specific primers for Mycobacterium tuberculosis on paraffin-embedded tissue were negative. BCG vaccination at birth, the histological appearance and the absence of M. tuberculosis DNA in the resected tissue indicated that osteomyelitis and scrofuloderma were a consequence of BCG. Osteomyelitis is a rarely occurring adverse effect of BCG vaccination, more commonly seen in immunosuppressed patients. In the patient described above, no symptoms of immunodeficiency were seen, however.
authors.affiliation: Departamento de Pediatría, Universidad del Rosario, Bogotá, D.C., Colombia. ifcorrales@yahoo.com
authors.forename: Ivohne Fernanda
authors.initials: IF
authors.lastname: Corrales
authors.forename: Jorge Alberto
authors.initials: JA
authors.lastname: Cortés
authors.forename: María Lucía
authors.initials: ML
authors.lastname: Mesa
authors.forename: Graciela
authors.initials: G
authors.lastname: Zamora
mesh_terms: D001500:BCG Vaccine / Q000009:adverse effects*; D004269:DNA, Bacterial / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000302:isolation & purification*; D010019:Osteomyelitis / Q000382:microbiology* / Q000601:surgery; D016133:Polymerase Chain Reaction; D013249:Sternum / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D014382:Tuberculosis, Cutaneous / Q000209:etiology*; D014394:Tuberculosis, Osteoarticular / Q000209:etiology*; D014611:Vaccination / Q000009:adverse effects
chemical_list: D001500:BCG Vaccine; D004269:DNA, Bacterial