Differential expression of natural killer receptors on Vdelta1 gammadelta T cells in HIV-1-infected individuals.
gammadelta T cells expressing the Vdelta1 T-cell receptor are increased in HIV-1-infected individuals. Since T-cell activation is modulated by inhibitory and activating natural killer receptors (NKRs), we investigated the expression of NKRs on Vdelta1 T cells in 22 HIV-1 infected patients by 2-color flow cytometry. We observed a strongly increased expression of several NKRs on ex vivo analyzed Vdelta1 T cells from HIV+ patients. Furthermore, we show that the in vitro stimulation of CD94- Vdelta1 T cells induced strong expression of inhibitory NKR CD94/CD159A (NKG2A). Our results suggest that the increased expression of NKRs might result from chronic activation of Vdelta1 T cells in HIV-1-infected persons.
Wesch
Daniela
D
Institute of Immunology, University of Kiel, Germany.
Kabelitz
Dieter
D
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015703:Antigens, CD / Q000032:analysis; D015497:HIV-1; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D037181:Lectins, C-Type / Q000032:analysis; D008213:Lymphocyte Activation; D055654:NK Cell Lectin-Like Receptor Subfamily C; D051920:NK Cell Lectin-Like Receptor Subfamily D; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D011971:Receptors, Immunologic / Q000032:analysis*; D054340:Receptors, KIR; D055607:Receptors, Natural Killer Cell; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; C527054:KLRC1 protein, human; C497869:KLRD1 protein, human; D037181:Lectins, C-Type; D055654:NK Cell Lectin-Like Receptor Subfamily C; D051920:NK Cell Lectin-Like Receptor Subfamily D; D016692:Receptors, Antigen, T-Cell, gamma-delta; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D055607:Receptors, Natural Killer Cell