Detection of human T-lymphotropic virus (HTLV) tax sequences in New York City blood donors seronegative for HTLV types 1 and 2.
A potential public health concern is the reported detection of the human T-lymphotropic virus (HTLV) tax gene in the lymphocytes of up to 11% of a low-risk group of New York City blood donors (NYBD). This study aimed to independently confirm the prevalence of HTLV tax sequences in 293 NYBD. All NYBD tested negative for antibodies to HTLV types 1 and 2 and HTLV Tax. HTLV tax sequences were not detected in the NYBD lymphocytes. These data demonstrate the lack of HTLV-1 tax in this group of NYBD at low risk for HTLV infection.
Dezzutti
Charlene S
CS
Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. cdezzutti@cdc.gov
Guenthner
Patricia C
PC
Daniel
Sylvester
S
Utz
Ursula
U
Cabrera
Thania
T
Marshall
James H
JH
Bianco
Celso
C
Lal
Renu B
RB
Cowan
Elliot P
EP
D000328:Adult; D000918:Antibody Specificity; D001782:Blood Donors; D005260:Female; D016356:Gene Products, tax / Q000276:immunology; D016355:Genes, pX; D015481:HTLV-I Antibodies / Q000097:blood* / Q000276:immunology; D015490:HTLV-I Infections / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D015482:HTLV-II Antibodies / Q000097:blood* / Q000276:immunology; D015491:HTLV-II Infections / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D015367:Human T-lymphotropic virus 2 / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007124:Immunoenzyme Techniques; D008214:Lymphocytes / Q000821:virology*; D008297:Male; D009519:New York City / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors
D016356:Gene Products, tax; D015481:HTLV-I Antibodies; D015482:HTLV-II Antibodies