Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments.
Platelets are highly reactive components of the circulatory system with well-documented hemostatic function. Recent studies extend platelet function to modulation of local inflammatory events through the release of chemokines, cytokines, and a number of immunomodulatory ligands, including CD154. We hypothesized that platelet-derived CD154 modulates adaptive immunity. The data reported herein demonstrate that platelets, via CD154, induce dendritic cell maturation, B cell isotype switching, and augment CD8(+) T cell responses both in vitro and in vivo. Platelet transfusion studies demonstrate that platelet-derived CD154 alone is sufficient to induce isotype switching and augment T lymphocyte function during viral infection, leading to enhanced protection against viral rechallenge. Additionally, depletion of platelets in normal mice results in decreased antigen-specific antibody production.
Elzey
Bennett D
BD
The University of Iowa, Department of Urology, Iowa City, IA 52242, USA.
Tian
Jun
J
Jensen
Robert J
RJ
Swanson
Axel K
AK
Lees
Jason R
JR
Lentz
Steven R
SR
Stein
Colleen S
CS
Nieswandt
Bernhard
B
Wang
Yiqiang
Y
Davidson
Beverly L
BL
Ratliff
Timothy L
TL
D000222:Adaptation, Physiological; D000256:Adenoviridae / Q000276:immunology; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D023201:CD40 Ligand / Q000097:blood / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D007113:Immunity, Innate; D051379:Mice; D008810:Mice, Inbred C57BL; D014777:Virus Diseases / Q000276:immunology
D023201:CD40 Ligand