Results of radiation therapy for uterine cervical cancer using high dose rate remote after loading system.
In Japan, radiotherapy with high dose rate remote after loading system (HDR-RALS) for intracavitary brachytherapy is the standard treatment for more than 30 years. This report showed the usefulness of HDR-RALS for uterine cervical cancer. From 1980 through 1999, 442 patients with uterine cervical cancers (stage I: 66, stage II: 161, stage III: 165, stage IV: 50) were treated. Radiotherapy was performed both external teletherapy and HDR-RALS. Overall survival rate at 5 years was 60.2%. The 5-year actuarial incidence of all complications was 16.4%. The 5-year actuarial incidence of all complications in cases treated with the sum doses of whole pelvic irradiation (without central shield) and RALS up to 49 Gy, 50 to 59 Gy or larger doses were 7.5%, 11.0% and 25.2%, respectively. Radiation therapy using HDR-RALS was very effective. While the dose of whole pelvic irradiation was increased, the actuarial incidence of all complications was increased.
Ogawa
Yoshihiro
Y
Department of Radiation Oncology, Tohoku University Graduate School of Medicine Sendai 980-8574, Japan. ogaway@rad.med.tohoku.ac.jp
Nemoto
Kenji
K
Kakuto
Yoshihisa
Y
Ariga
Hisanori
H
Matsushita
Haruo
H
Takeda
Ken
K
Takahashi
Chiaki
C
Gallardo
Britton
B
Richard
Keith
K
Takai
Yoshihiro
Y
Yamada
Shogo
S
D000206:Actuarial Analysis; D000230:Adenocarcinoma / Q000532:radiotherapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D018288:Carcinoma, Small Cell / Q000532:radiotherapy*; D004487:Edema / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D050723:Fractures, Bone / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007564:Japan; D008875:Middle Aged; D011829:Radiation Dosage; D012189:Retrospective Studies; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*; D014594:Uterine Neoplasms / Q000532:radiotherapy*