Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis.
Children with acute otitis media underwent tympanocentesis and were given a single dose of 30 mg of azithromycin/kg of body weight. At day 28, the overall clinical cure rate was 206 of 242 (85%). Clinical cure rates for patients infected with Streptococcus pneumoniae (67 of 76; 88%) and Haemophilus influenzae (28 of 44; 64%) were consistent with historical rates for the 5-day dosing regimen.
Dunne
Michael W
MW
Pfizer Global Research & Development, New London, Connecticut 06320, USA. michael_w_dunne@groton.pfizer.com
Khurana
Chandra
C
Mohs
Adriano Arguedas
AA
Rodriguez
Adib
A
Arrieta
Antonio
A
McLinn
Samuel
S
Krogstad
Judy A
JA
Blatter
Mark
M
Schwartz
Richard
R
Vargas
Sergio L
SL
Emparanza
Paz
P
Fernandez
Pilar
P
Gooch
Willis M
WM
Aspin
Mary
M
Podgore
John
J
Roine
Irmeli
I
Blumer
Jeffrey L
JL
Ehrlich
Garth D
GD
Chow
Jean
J
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017963:Azithromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004322:Drainage; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010033:Otitis Media / Q000188:drug therapy / Q000382:microbiology / Q000628:therapy*
D000900:Anti-Bacterial Agents; D017963:Azithromycin