title: Manganese superoxide dismutase expression correlates with a poor prognosis in gastric cancer.
abstract: OBJECTIVE
  The biologic significance of superoxide dismutase (SOD) in transformed gastric carcinoma cells is unclear. The aim of this study was to examine the role of SOD as a prognostic indicator of gastric carcinomas and its association with other clinicopathological factors.
  
  
  METHODS
  Expression of MnSOD and Cu/ZnSOD was evaluated immunohistochemically in gastric carcinomas and adenomas using tissue-array methods. The correlation between SOD immunoreactivity and clinical outcome or clinicopathological factors was investigated.
  
  
  RESULTS
  MnSOD expression was associated with a poor patient prognosis and was strong in advanced gastric cancer, in the well-differentiated type and in the presence of lymphoid stroma (p < 0.05). On the other hand, there was no association between Cu/ZnSOD expression and patient survival. Cu/ZnSOD immunoreactivity was strong in advanced gastric cancer and in the presence of lymphoid stroma (p < 0.05) and was weak in signet ring cell type.
  
  
  CONCLUSIONS
  MnSOD immunoreactivity is significantly associated with poor outcome in gastric carcinoma patients although both MnSOD and Cu/ZnSOD have a connection with several clinicopathological parameters with some overlap.
authors.affiliation: Department of Anatomy, College of Medicine, Seoul National University, Seoul, Korea.
authors.forename: Jeong Jin
authors.initials: JJ
authors.lastname: Kim
authors.forename: Seoung Wan
authors.initials: SW
authors.lastname: Chae
authors.forename: Gwong Cheung
authors.initials: GC
authors.lastname: Hur
authors.forename: Sung Jin
authors.initials: SJ
authors.lastname: Cho
authors.forename: Min Kyu
authors.initials: MK
authors.lastname: Kim
authors.forename: Jimi
authors.initials: J
authors.lastname: Choi
authors.forename: Seon Young
authors.initials: SY
authors.lastname: Nam
authors.forename: Woo Ho
authors.initials: WH
authors.lastname: Kim
authors.forename: Han-Kwang
authors.initials: HK
authors.lastname: Yang
authors.forename: Byung Lan
authors.initials: BL
authors.lastname: Lee
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000556:secondary / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D013482:Superoxide Dismutase