title: Prevention of reperfusion lung injury by lidocaine in isolated rat lung ventilated with higher oxygen levels.
abstract: BACKGROUND
  Lidocaine, an antiarrhythmic drug has been shown to be effective against post-ischaemic reperfusion injury in heart. However, its effect on pulmonary reperfusion injury has not been investigated.
  
  
  OBJECTIVE
  We investigated the effects of lidocaine on a postischaemic reperfused rat lung model.
  
  
  METHODS
  Lungs were isolated and perfused at constant flow with Krebs-Henseilet buffer containing 4% bovine serum albumin, and ventilated with 95% oxygen mixed with 5% CO2. Lungs were subjected to ischaemia by stopping perfusion for 60 minutes followed by reperfusion for 10 minutes. Ischaemia was induced in normothermic conditions.
  
  
  RESULTS
  Postischaemic reperfusion caused significant (p < 0.0001) higher wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure compared to control lungs. Lidocaine, at a dose of 5mg/Kg b.w. was found to significantly (p < 0.0001) attenuate the increase in the wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure observed in post-ischaemic lungs.
  
  
  CONCLUSIONS
  Lidocaine is effective in preventing post-ischaemic reperfusion injury in isolated, perfused rat lung.
authors.affiliation: University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708, USA. kumuda@uthct.edu
authors.forename: K C
authors.initials: KC
authors.lastname: Das
authors.forename: H P
authors.initials: HP
authors.lastname: Misra
mesh_terms: D000818:Animals; D008012:Lidocaine / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects*; D008297:Male; D023421:Models, Animal; D010100:Oxygen / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000517:prevention & control*
chemical_list: D008012:Lidocaine; D010100:Oxygen