Mitomycin C-induced renal insufficiency: a case report.
A 58-year-old normotensive male with normal renal function and gastric cancer underwent total gastrectomy and received adjuvant chemotherapy with mitomycin C (MMC) for 10 months. He developed anemia, hypertension, and renal function impairment 9 months after initiation of chemotherapy. Kidney biopsy showed thrombotic microangiopathy with marked mesangiolysis and expansion of the subendothelial space resulting in cystic dilation of the glomerular capillaries, and cellular atypia in the tubular cells. His renal function deteriorated gradually then stabilized after treatment with plasma exchange, antihypertensive agents, and antiplatelet agents. He had no sign of tumor recurrence after 3 years of follow-up. We suggest that patients receiving MMC should have their blood pressure and renal function closely monitored for the possibility of development of drug-induced renal insufficiency.
Wen
Mei-Chin
MC
Department of Pathology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. mewen@vghtc.vghtc.gov.tw
Chen
Cheng-Hsu
CH
Ho
William L
WL
D000743:Anemia, Hemolytic / Q000139:chemically induced; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000009:adverse effects*; D051437:Renal Insufficiency / Q000150:complications*; D013274:Stomach Neoplasms / Q000188:drug therapy
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin