title: Ring substituted analogues of 5-aminomethyl-10,11-dihydro-dibenzo[a,d]cycloheptene (AMDH): potential modes of binding to the 5-HT(2A) receptor.
abstract: The synthesis and 5-HT(2A) receptor affinities of 2-substituted-5-aminomethyl-10,11-dihydrodibenzo[a,d]cycloheptene (AMDH) derivatives are described. Comparison of the effects of substitution on affinities allowed assignment of potential binding modes in comparison with DOB-like agonists/antagonists and 3-substituted 1-(aminomethyl)-9,10-dihydroanthracene structures.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Peddi
authors.forename: Bryan L
authors.initials: BL
authors.lastname: Roth
authors.forename: Richard A
authors.initials: RA
authors.lastname: Glennon
authors.forename: Richard B
authors.initials: RB
authors.lastname: Westkaemper
mesh_terms: D003517:Cyclopentanes / Q000138:chemical synthesis / Q000494:pharmacology*; D007202:Indicators and Reagents; D007700:Kinetics; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D011869:Radioligand Assay; D044402:Receptor, Serotonin, 5-HT2A / Q000187:drug effects / Q000378:metabolism*; D018490:Serotonin Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: C482470:5-aminomethyl-10,11-dihydro-dibenzo(a,d)cycloheptene; D003517:Cyclopentanes; D007202:Indicators and Reagents; D008024:Ligands; D044402:Receptor, Serotonin, 5-HT2A; D018490:Serotonin Agents