Clinical, radiographic, histologic, and histomorphometric comparison of PepGen P-15 particulate and PepGen P-15 flow in extraction sockets: a same-mouth case study.
OBJECTIVE
Although the efficacy of PepGen P-15 particulate has been conclusively demonstrated in two multicenter clinical studies, the effect of a new hydrogel formulation containing PepGen P-15 on bone repair has not been previously demonstrated.


METHODS
PepGen P-15 Flow contains PepGen P-15 particulate in a biocompatible hydrogel, which provides spacing between the particles. In this case study, bone repair of both PepGen P-15 particles and PepGen P-15 Flow was compared to natural bone in same-mouth extraction sockets.


RESULTS
The radiographic, histologic, and histomorphometric evaluations showed enhanced bone formation and faster particle resorption with PepGen P-15 Flow compared to the PepGen P-15 particulate.


CONCLUSIONS
The accelerated bone formation by PepGen P-15 Flow may provide faster implant placement.
Hahn
Jack
J
Division of Oral & Maxillofacial Pathology, University of Minnesota School of Dentistry, Minneapolis, Minnesota, USA. cid@iglou.com
Rohrer
Michael D
MD
Tofe
Andrew J
AJ
D000539:Alveolar Process / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000494:pharmacology*; D016025:Bone Transplantation; D003758:Dental Implantation, Endosseous; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D014081:Tooth Extraction; D020390:Tooth Socket / Q000601:surgery*
D018786:Bone Substitutes; D005782:Gels; C403137:PepGen P-15