Simple one-flask method for the preparation of hydroxamic acids.
[reaction: see text] A one-step conversion of carboxylic acids to hydroxamic acids under very mild conditions is described. This simple and efficient method has been applied for the synthesis of enantiopure hydroxamate of alpha-amino acids and peptides.
Giacomelli
Giampaolo
G
Dipartimento di Chimica, Università degli Studi di Sassari, via Vienna 2, I-07100 Sassari, Italy. ggp@uniss.it
Porcheddu
Andrea
A
Salaris
Margherita
M
D002264:Carboxylic Acids / Q000737:chemistry; D006877:Hydroxamic Acids / Q000138:chemical synthesis*
D002264:Carboxylic Acids; D006877:Hydroxamic Acids