title: A patient with primary biliary cirrhosis complicated with slowly progressive insulin-dependent diabetes mellitus.
abstract: We report a case of primary biliary cirrhosis (PBC) complicated by slowly progressive insulin-dependent diabetes mellitus (SPIDDM). A 67-year-old woman was diagnosed as having PBC based on clinical manifestations and a positive result of anti-mitochondrial antibody. Furthermore, SPIDDM was diagnosed by her clinical course and a positive result of anti-glutamic acid decarboxylase antibody. Both PBC and SPIDDM are considered to be autoimmune diseases. However, the coexistence of PBC and SPIDDM is extremely rare. Liver cirrhosis sometimes accompanies hyperglycemia. When the etiology of liver cirrhosis is an autoimmune disorder such as PBC, SPIDDM should be considered as a cause of hyperglycemia.
authors.affiliation: Okinawa Kenritsu Hokubu Hospital, Okinawa.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nakasone
authors.forename: Kazushi
authors.initials: K
authors.lastname: Kinjo
authors.forename: Masaaki
authors.initials: M
authors.lastname: Yamashiro
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Kamiyama
authors.forename: Sakiko
authors.initials: S
authors.lastname: Kamiyama
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Miyazato
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Matsushita
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Arakawa
authors.forename: Takeharu
authors.initials: T
authors.lastname: Ohshiro
authors.forename: Shiyu
authors.initials: S
authors.lastname: Toma
authors.forename: Kiyoharu
authors.initials: K
authors.lastname: Chinen
authors.forename: Masato
authors.initials: M
authors.lastname: Yamashiro
authors.forename: Masatake
authors.initials: M
authors.lastname: Miyagi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Makishi
authors.forename: Akira
authors.initials: A
authors.lastname: Hokama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakugawa
authors.forename: Fukunori
authors.initials: F
authors.lastname: Kinjo
authors.forename: Atsushi
authors.initials: A
authors.lastname: Saito
mesh_terms: D000368:Aged; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000032:analysis; D003131:Combined Modality Therapy; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D004032:Diet; D018450:Disease Progression; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007564:Japan; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D008111:Liver Function Tests; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007328:Insulin