title: The regulation and activation potential of autoreactive B cells.
abstract: Anti-double-stranded DNA (dsDNA) B cells persist even in nonautoimmune- prone animals. In this review, we summarize data regarding the activation potential of these cells. Provision of cognate CD4 T cell help to anti-dsDNA B cells in nonautoimmune mice not only drives their maturation and entry into the B cell follicle, but also leads to secretion of anti-dsDNA autoantibodies. Intriguingly, if T regulatory cells are provided along with T helper cells, the antibody response of anti-dsDNA B cells is diminished. We have also found that T-independent stimulation with CpG oligodeoxynucleotides leads to the proliferation and enhanced recovery of antidsDNA B cells in vitro. These data suggest that control of anti-dsDNA antibody production may rely on elements from both the innate and adaptive arms of the immune system.
authors.affiliation: The Wistar Institute, Philadelphia, PA 19104, USA.
authors.forename: Michele L
authors.initials: ML
authors.lastname: Fields
authors.forename: Su-Jean
authors.initials: SJ
authors.lastname: Seo
authors.forename: Simone A
authors.initials: SA
authors.lastname: Nish
authors.forename: Jeff H
authors.initials: JH
authors.lastname: Tsai
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Caton
authors.forename: Jan
authors.initials: J
authors.lastname: Erikson
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology*; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology*; D004247:DNA / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008211:Lymphocyte Cooperation / Q000276:immunology; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear; D004247:DNA