An autopsy case of sudden death in a patient with giant cell myocarditis.
We present a case of a 28-year-old male weight lifter who died suddenly while driving a bicycle. Forensic autopsy and histopathological examinations revealed granulomatous lesions in the myocardium and hilar lymph nodes. The latter had massive caseation necrosis, epithelioid granulomas and Langhans' giant cells suggestive of tuberculosis. However, the myocardium showed predominantly multinucleated foreign body and myogenic giant cells, lymphocytes, plasma cells, macrophages, eosinophils. Staining for acid-fast bacilli was negative. The present case highlights the difficulty in establishing whether the granulomatous lesions in the hilar lymph nodes and the myocardium are incidental findings or whether they are related by the same pathogenetic mechanisms.
Singh
Ahongshangbam Meina
AM
Department of Pathology, Regional Institute of Medical Sciences, Imphal, Manipur, India. drmeina@37.com
Debnath
Kaushik
K
Devi
Soibam Subadani
SS
Devi
Pukhrambam Gayatri
PG
Konjengbam
Ratan
R
Nabachandra
Huidrom
H
D000328:Adult; D001344:Autopsy; D009202:Cardiomyopathies / Q000150:complications* / Q000175:diagnosis*; D003645:Death, Sudden / Q000209:etiology*; D006101:Granuloma, Giant Cell / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D009205:Myocarditis / Q000150:complications* / Q000175:diagnosis*