Developments in microarray technologies.
The focus of high-throughput drug discovery has progressed through the genome and the transcriptome and is now moving towards more difficult problems in assessing the proteome, glycome and metabolome. Microarrays are currently the major tool in the assessment of gene expression via cDNA or RNA analysis; however, they are also used to screen libraries of proteins and small molecules. Microarrays have helped to extract more information from smaller sample volumes and enabled the incorporation of low-cost high-throughput assays in the drug discovery process. The technology continues to develop and is being rapidly transferred into more challenging areas, with the potential to further aid and enhance the drug discovery process through the development of, for example, proteomic, glycomic and tissue arrays.
Howbrook
David N
DN
School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton BN2 4GJ, UK.
van der Valk
Anne M
AM
O'Shaughnessy
Meg C
MC
Sarker
Dipak K
DK
Baker
Simon C
SC
Lloyd
Andrew W
AW
D020869:Gene Expression Profiling; D036103:Nanotechnology / Q000379:methods* / Q000639:trends; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012106:Research; D013678:Technology, Pharmaceutical / Q000639:trends*