Hepatic artery thrombosis after liver transplantation and genetic factors: prothrombin G20210A polymorphism.
Hepatic artery thrombosis (HAT) after liver transplantation is associated with a high incidence of graft failure. The incidence ranges between 2% and 25%, with an overall incidence of approximately 7%. Different risk factors have been associated, but the participation of genetic factors in the cause of HAT is less well studied. A single-base change (G to A) at position 20210 in the 3' untranslated region of the prothrombin gene is associated with increased plasma levels of prothrombin and might therefore increase the risk for thrombosis. We reviewed our HAT experience in 11 years at Medical College of Virginia hospitals of 491 patients undergoing 533 liver transplantations. There were 14 liver grafts with documented HAT (2.62%) in 13 patients. Prothrombin G20210A polymorphism was found in the DNA obtained from 2 of 14 liver allograft tissues (14.2%) but not in the DNA from leukocytes obtained from the peripheral blood of recipients with HAT.
Mas
Valeria R
VR
Department of Pathology, Virginia Commonwealth University, Richmond, Virginia 23298-0248, USA.
Fisher
Robert A
RA
Maluf
Daniel G
DG
Wilkinson
David S
DS
Garrett
Carleton T
CT
Ferreira-Gonzalez
Andrea
A
D019943:Amino Acid Substitution; D005838:Genotype; D006499:Hepatic Artery; D006785:Hospitals, University; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D020125:Mutation, Missense; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D011516:Prothrombin / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D014768:Virginia
D011516:Prothrombin