Influence of new gamma-hydroxybutyric acid amide analogues on the central nervous system activity in mice.
The present study investigates the activity of four gamma-hydroxybutyric acid amide analogues (BM-68, BM-74, BM-75 and BM-76) in two models of chemically induced seizures, i.e. picrotoxin- and pentetrazole-induced seizures and in the thiopental-induced sleep test. The results of pharmacological in vivo experiments with the gamma-hydroxybutyric acid amide analogues presented below show that the compounds possess variable influence on the central nervous system in mice.
Sałat
Kinga
K
Department of Pharmacodynamics, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Kraków, Poland.
Mendyk
Anna
A
Librowski
Tadeusz
T
Czarnecki
Ryszard
R
Malawska
Barbara
B
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology; D006885:Hydroxybutyrates / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012890:Sleep / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D006885:Hydroxybutyrates; C111420:4-hydroxybutyric acid; D005680:gamma-Aminobutyric Acid