title: Prevalence and incidence of hyperplastic polyps and adenomas in familial colorectal cancer: correlation between the two types of colon polyps.
abstract: OBJECTIVE
  Colorectal adenomas are recognised as precursors of colorectal carcinomas. The significance of hyperplastic (metaplastic) colorectal polyps is unknown. The relationship between hyperplastic polyps and adenomas, and the prevalence and incidence of these lesions were evaluated in individuals predisposed to familial colorectal cancer.
  
  
  METHODS
  A total of 299 individuals participating in our surveillance programme during 1990-2000 were retrospectively evaluated. Subjects were classified into three groups: hereditary non-polyposis syndrome (HNPCC) (n=108), hereditary colorectal cancer (HCRC) (n=127), and individuals with empirical risk estimates-two close relatives (TCR) (n=64). Findings from 780 colonoscopies were evaluated regarding prevalence and incidence of hyperplastic polyps and adenomas. Correlations between hyperplastic polyps and adenomas were calculated by Pearson correlation.
  
  
  RESULTS
  In total, 292 hyperplastic polyps and 186 adenomas were observed in 98 and 90 individuals, respectively. A positive correlation was found between the numbers of hyperplastic polyps and adenomas (r=0.40; p<0.001). Correlations between adenomas and hyperplastic polyps were similar in the three groups. The risk of detecting new hyperplastic polyps (odds ratio 5.41) or adenomas (OR 2.56) increased significantly when there was a positive finding at first colonoscopy.
  
  
  CONCLUSIONS
  Hyperplastic polyps as well as adenomas may identify individuals with a high risk of colorectal cancer. This information is important when these individuals are selected and included in tailored surveillance programmes.
authors.affiliation: Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Liljegren
authors.forename: A
authors.initials: A
authors.lastname: Lindblom
authors.forename: S
authors.initials: S
authors.lastname: Rotstein
authors.forename: B
authors.initials: B
authors.lastname: Nilsson
authors.forename: C
authors.initials: C
authors.lastname: Rubio
authors.forename: E
authors.initials: E
authors.lastname: Jaramillo
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D003106:Colon / Q000473:pathology; D003111:Colonic Polyps / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006965:Hyperplasia / Q000235:genetics; D015994:Incidence; D008297:Male; D010375:Pedigree; D011230:Precancerous Conditions / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors