title: Cardiopulmonary bypass is not associated with increased jugular venous blood free radical activity.
abstract: We have measured jugular venous oxygen saturation (sjv(O2)) and lactate, arterial and jugular venous blood levels of lipid peroxidation products--malondialdehyde (MDA) and diene conjugates as an index of free radical activity in eight adults undergoing coronary artery bypass surgery. Measurements were carried out at six specific times: T1--within 5 min before cardiopulmonary bypass (CPB), T2--within the first minute after the commencement of CPB, T3--during stable temperature (28 degrees C) on CPB, T4--during rewarming at 34 degrees C, T5--15 min after CPB and T6--at skin closure. There were no significant changes in arterial, jugular venous and arterio-jugular venous (a-jv) differences in diene conjugates and MDA. There was no correlation between sjv(O2), lactate and a-jv differences in MDA and diene conjugates. These results are not indicative of ischaemia-reperfusion injury across the cerebral circulation during hypothermic CPB.
authors.affiliation: University Department of Anaesthesia, Royal Liverpool University Hospital, Liverpool UK.
authors.forename: P C
authors.initials: PC
authors.lastname: Ip-Yam
authors.forename: P G
authors.initials: PG
authors.lastname: Browning
authors.forename: S
authors.initials: S
authors.lastname: Behl
mesh_terms: D000466:Alkadienes / Q000097:blood; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002560:Cerebrovascular Circulation; D005609:Free Radicals / Q000097:blood*; D006801:Humans; D007036:Hypothermia, Induced; D007601:Jugular Veins; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D015427:Reperfusion Injury / Q000209:etiology; D013997:Time Factors
chemical_list: D000466:Alkadienes; D005609:Free Radicals; D008315:Malondialdehyde