[Is there a circadian rhythm of interleukin 15 in humans?].
Nine healthy young men were studied under strict conditions for 48 h. The subjects were selected after a clinical examination and exploration of their rest-activity rhythm by actometry. The circadian rhythms of cortisol (peak at 8 AM) and melatonin (peak at 4 AM) were confirmed. The interleukin 15 (IL-15) was detected in the plasma samples with an Elisa kit (R&D System), but no reproducible variation could be observed during day 1 and day 2. In conclusion, in the conditions of our study, no rhythm was observed for IL-15. Our population will be completed with the inclusion of 6 additional subjects. These results will be specified.
Chevalier
V
V
Inserm unité 484, centre Jean-Perrin, 58, rue Montalembert, 63011, Clermont-Ferrand, France.
Gachon
F
F
Kwiatkowski
F
F
Papon
J
J
Curé
H
H
Doly
M
M
Madelmont
J-C
JC
Chollet
Ph
P
D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D019409:Interleukin-15 / Q000097:blood*; D008297:Male; D008550:Melatonin / Q000097:blood; D012016:Reference Values
D019409:Interleukin-15; D008550:Melatonin; D006854:Hydrocortisone