title: Thrombolysis for prosthetic valve malfunction: case report and review.
abstract: A 40 year old female with severe mitral valve stenosis, underwent mitral valve replacement by single disc valve 4 years ago. She presented at this admission with a new onset of congestive heart failure. The prothrombin time was inadequate with international normalized ratio (INR) 1.43. Transthoracic echocardiography revealed high pressure gradient across the mitral valve. Fluoroscopy demonstrated restrictive opening of single disc motion. Intravenous thrombolysis was given for presumptive diagnosis of prosthetic valve thrombosis. The patient gradually improved and did not have to undergo surgical correction.
authors.affiliation: Division of Cardiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Jaruwun
authors.initials: J
authors.lastname: Chaiworramukkun
authors.forename: Pakorn
authors.initials: P
authors.lastname: Chandanamattha
authors.forename: Sarana
authors.initials: S
authors.lastname: Boonbaichaiyapruck
mesh_terms: D000328:Adult; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000188:drug therapy* / Q000209:etiology*; D008946:Mitral Valve Stenosis / Q000601:surgery*; D011183:Postoperative Complications; D011475:Prosthesis Failure; D015912:Thrombolytic Therapy