Disruption of circadian coordination accelerates malignant growth in mice.
An animal model (mice B6D2F1) was developed to study the consequence of suprachiasmatic nuclei (SCN) destruction on tumor growth. SCN destruction abolished the rest-activity and body temperature rhythms and markedly altered the rhythms in serum corticosterone concentration and lymphocyte count. Tumor growth was faster in mice with lesioned SCN than in controls for both tumor models studied, Glasgow osteosarcoma (GOS) and pancreatic adenocarcinoma (P03). This shows that disruption of circadian coordination accelerates malignant growth in mice, suggesting that the host circadian clock controls tumor progression.
Filipski
Elisabeth
E
INSERM E 0654 "Chronotherapeutique des cancers" (Université Paris XI), Hôpital Paul Brousse, 94800, Villejuif, France.
King
Verdun M
VM
Li
XiaoMei
X
Granda
Teresa G
TG
Mormont
Marie-Christine
MC
Claustrat
Bruno
B
Hastings
Michael H
MH
Lévi
Francis
F
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D001833:Body Temperature Regulation; D001859:Bone Neoplasms / Q000473:pathology*; D002455:Cell Division; D045744:Cell Line, Tumor / Q000637:transplantation; D002940:Circadian Rhythm; D003345:Corticosterone / Q000378:metabolism; D018450:Disease Progression; D008297:Male; D051379:Mice; D012516:Osteosarcoma / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology*; D013493:Suprachiasmatic Nucleus / Q000293:injuries / Q000503:physiopathology
D003345:Corticosterone