title: Inflammation-sensitive plasma proteins are associated with future weight gain.
abstract: Cross-sectional studies have associated obesity and other components of the so-called metabolic syndrome with low-grade inflammation. The temporal and causal relations of this association have not been fully explored. This study explored whether elevated levels of inflammation-sensitive plasma proteins (ISPs) (fibrinogen, orosomucoid, alpha1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with future weight gain. Five ISPs were measured in 2,821 nondiabetic healthy men (38-50 years of age) who were reexamined after a mean follow-up of 6.1 years. Future weight gain was studied in relation to the number of elevated ISPs (i.e., in the top quartile). The proportion with a large weight gain (75th percentile >/= 3.8 kg) was 21.0, 25.9, 26.8, and 28.3%, respectively, among men with none, one, two, and three or more ISPs in the top quartile (P for trend 0.0005). This relation remained significant after adjustments for weight at baseline, follow-up time, height (at baseline and follow-up), physical inactivity (at baseline and follow-up), smoking (at baseline and follow-up), high alcohol consumption, and insulin resistance. The relations were largely similar for all individual ISPs. Elevated ISP levels predict a large weight gain in middle-aged men. This relation could contribute to the relation between inflammation, the metabolic syndrome, and cardiovascular disease.
authors.affiliation: Department of Community Medicine, Lund University, Malmö, Sweden. gunnar.engstrom@smi.mas.lu.se
authors.forename: Gunnar
authors.initials: G
authors.lastname: Engström
authors.forename: Bo
authors.initials: B
authors.lastname: Hedblad
authors.forename: Lars
authors.initials: L
authors.lastname: Stavenow
authors.forename: Peter
authors.initials: P
authors.lastname: Lind
authors.forename: Lars
authors.initials: L
authors.lastname: Janzon
authors.forename: Folke
authors.initials: F
authors.lastname: Lindgärde
mesh_terms: D000328:Adult; D002570:Ceruloplasmin / Q000378:metabolism; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005340:Fibrinogen / Q000378:metabolism*; D005500:Follow-Up Studies; D006242:Haptoglobins / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D009961:Orosomucoid / Q000378:metabolism; D011237:Predictive Value of Tests; D012307:Risk Factors; D015430:Weight Gain / Q000502:physiology*; D000515:alpha 1-Antitrypsin / Q000378:metabolism
chemical_list: D006242:Haptoglobins; D009961:Orosomucoid; D000515:alpha 1-Antitrypsin; D005340:Fibrinogen; D002570:Ceruloplasmin