Synthesis of a hyaluronan neoglycopolymer by ring-opening metathesis polymerization.
A hyaluronan (HA)-derived disaccharide was synthesized bearing an n-pentenyl spacer arm, which facilitated disaccharide derivatization with a norbornene template. Subsequent ring opening metathesis polymerization of the monomer produced an HA-mimetic neoglycopolymer of low polydispersity.
Iyer
Suri
S
Department of Surgery and Biomedical Engineering, Emory University, Atlanta, GA 30322, USA.
Rele
Shyam
S
Grasa
Gabriela
G
Nolan
Steven
S
Chaikof
Elliot L
EL
D006820:Hyaluronic Acid / Q000138:chemical synthesis*; D011108:Polymers / Q000138:chemical synthesis*
D011108:Polymers; D006820:Hyaluronic Acid