title: Neuroimaging communality between schizophrenia and obsessive compulsive disorder: a putative basis for schizo-obsessive disorder?
abstract: Four major brain regions have been repeatedly implicated in the pathophysiology of obsessive compulsive disorder (OCD) in in vivo neuroimaging studies: the caudate nucleus, the orbitofrontal cortex, the anterior cingulate gyrus and the mediodorsal thalamic nucleus. The present review describes the neuroimaging studies on schizophrenia, pertaining to these brain regions. Our working hypothesis is that such common brain regions, if dysfunctional in schizophrenic patients, would be candidates for a neural network subserving the newly emerging syndrome of schizo-obsessive disorder. Findings, though, are controversial. We conclude that further studies, aimed at specific monitoring of these brain regions, in patients suffering from the schizo-obsessive syndrome are warranted.
authors.affiliation: Outpatient Department, Geha Mental Health Center, P.O.Box 102, Petach Tikva 49100, Israel. risseroff@clalit.org.il
authors.forename: Ruth
authors.initials: R
authors.lastname: Gross-Isseroff
authors.forename: Haggai
authors.initials: H
authors.lastname: Hermesh
authors.forename: Joseph
authors.initials: J
authors.lastname: Zohar
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
mesh_terms: D001921:Brain / Q000002:abnormalities / Q000378:metabolism*; D002421:Caudate Nucleus / Q000002:abnormalities / Q000378:metabolism; D006179:Gyrus Cinguli / Q000002:abnormalities / Q000378:metabolism; D006801:Humans; D020645:Mediodorsal Thalamic Nucleus / Q000002:abnormalities / Q000378:metabolism; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000002:abnormalities / Q000378:metabolism; D012559:Schizophrenia / Q000175:diagnosis* / Q000378:metabolism*; D009626:Terminology as Topic; D014055:Tomography, Emission-Computed