title: Collagen platelet receptor polymorphisms integrin alpha2beta1 C807T and GPVI Q317L and risk of ischemic stroke.
abstract: Several polymorphisms of integrin alpha2beta1 and glycoprotein (GP) VI that may modify platelet-collagen interactions or subsequent signaling have been described. We conducted a case-control study involving 180 stroke patients and 172 controls to determine whether the alpha2 C807T and GPVI Q317L polymorphisms were associated with an increased risk of ischemic stroke. We found no statistically significant differences in the distribution of alpha2 C807T and GPVI Q317L in patients and controls overall or after stratification by etiological subtype. The GPVI 317QQ genotype was found to be over-represented in a subgroup of patients >/=60 years compared to corresponding controls. However, this association did not remain significant after adjustment for other cardiovascular risk factors. Our results do not support a role for the integrin alpha2 C807T and GPVI Q317L polymorphisms in the development of first-ever ischemic stroke. However, larger studies are required to confirm this.
authors.affiliation: Thrombosis and Haemophilia Unit, Royal Perth Hospital, Perth, Australia. vanessa.cole@health.wa.gov.au
authors.forename: V J
authors.initials: VJ
authors.lastname: Cole
authors.forename: J M
authors.initials: JM
authors.lastname: Staton
authors.forename: J W
authors.initials: JW
authors.lastname: Eikelboom
authors.forename: G J
authors.initials: GJ
authors.lastname: Hankey
authors.forename: Q
authors.initials: Q
authors.lastname: Yi
authors.forename: Y
authors.initials: Y
authors.lastname: Shen
authors.forename: M C
authors.initials: MC
authors.lastname: Berndt
authors.forename: R I
authors.initials: RI
authors.lastname: Baker
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D038982:Integrin alpha2beta1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010980:Platelet Membrane Glycoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000235:genetics*
chemical_list: D038982:Integrin alpha2beta1; D010980:Platelet Membrane Glycoproteins; C098341:platelet membrane glycoprotein VI