Skeletal myoblast transplant in heart failure.
Despite recent advances in the prevention and treatment of ischemic heart disease (IHD), treatment of patients with heart failure secondary to myocardial infarction remains a therapeutic challenge. Heart transplantation has emerged as a viable option but is fraught with problems of supply. Mechanical assist devices are extremely expensive and dynamic cardiomyoplasty has shown only limited success in the clinical setting. Recent insights into the pathogenesis of myocardial diseases and the progress made in the field of molecular biology have resulted in the development of new strategies at molecular as well as cellular levels for cardiac muscle repair. One such strategy is to augment ventricular function by means of cellular cardiomyoplasty through intracardiac cell grafting using adult and fetal cardiomyocytes, stem cells, and autologous skeletal myoblasts.
Sim
Eugene K W
EK
Division of Cardiothoracic Surgery, National University of Singapore, Singapore. sursimkw@nus.edu.sg
Jiang
Shujia
S
Ye
Lei
L
Lim
Y L
YL
Ooi
Oon C
OC
Haider
Khawaja H
KH
D000818:Animals; D017690:Cell Transplantation / Q000379:methods; D006333:Heart Failure / Q000601:surgery*; D006801:Humans; D032448:Myoblasts, Skeletal / Q000637:transplantation*; D014182:Transplantation, Autologous