The regulation and activation potential of autoreactive B cells.
Anti-double-stranded DNA (dsDNA) B cells persist even in nonautoimmune- prone animals. In this review, we summarize data regarding the activation potential of these cells. Provision of cognate CD4 T cell help to anti-dsDNA B cells in nonautoimmune mice not only drives their maturation and entry into the B cell follicle, but also leads to secretion of anti-dsDNA autoantibodies. Intriguingly, if T regulatory cells are provided along with T helper cells, the antibody response of anti-dsDNA B cells is diminished. We have also found that T-independent stimulation with CpG oligodeoxynucleotides leads to the proliferation and enhanced recovery of antidsDNA B cells in vitro. These data suggest that control of anti-dsDNA antibody production may rely on elements from both the innate and adaptive arms of the immune system.
Fields
Michele L
ML
The Wistar Institute, Philadelphia, PA 19104, USA.
Seo
Su-Jean
SJ
Nish
Simone A
SA
Tsai
Jeff H
JH
Caton
Andrew J
AJ
Erikson
Jan
J
D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology*; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology*; D004247:DNA / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008211:Lymphocyte Cooperation / Q000276:immunology; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology
D000974:Antibodies, Antinuclear; D004247:DNA