Synthesis and fungicidal activity of lipophylic N- and O-acyl derivatives of beta-hydroxy DL-alpha-amino acids.
Synthesis of N- and O-acyl derivatives of DL-serine and threo-DL-phenylserine was accomplished by a regioselective acylation of the corresponding amino acid. The residues introduced into amino acid structure contain hydrophobic long chain or aromatic, namely lauroyl, myristoyl and phenylacetyl moieties. The fungicidal activity against six strains of fungi was studied. Several compounds were found to be effective against growth of fungi, and O-myristoyl-DL-serine 2 and N-phenylacetyl-threo-DL-phenylserine 8 completely inhibited the growth of the mycelium of the fungus Verticillium dahliae.
Dirvianskyte
Nijole
N
Institute of Biochemistry, Mokslininku 12, 2600 Vilnius, Lithuania.
Straukas
Juozapas
J
Razumas
Valdemaras
V
Butkus
Eugenius
E
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D020171:Botrytis / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects; D006880:Hydroxy Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000596:Amino Acids; D000935:Antifungal Agents; D006880:Hydroxy Acids