Cell adhesion molecules: key players in memory consolidation?
Experimental evidence implies that L1 and neural cell adhesion molecule (NCAM) are involved in long-term memory formation. Changes in their expression and glycosylation appear to modify the synaptic strength underlying memory consolidation. Interference with L1 and NCAM function in a variety of learning tasks in different species severely attenuates memory consolidation, indicating their involvement in an evolutionary conserved mechanism of neural plasticity.
Welzl
Hans
H
Division of Neuroanatomy and Behavior, Institute of Anatomy, University of Zurich, CH-8057 Zurich, Switzerland.
Stork
Oliver
O
D000818:Animals; D008568:Memory / Q000502:physiology*; D039842:Neural Cell Adhesion Molecule L1 / Q000502:physiology*; D019006:Neural Cell Adhesion Molecules / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*
D039842:Neural Cell Adhesion Molecule L1; D019006:Neural Cell Adhesion Molecules