title: Autogenous bone graft and ePTFE membrane in the treatment of peri-implantitis. II. Stereologic and histologic observations in cynomolgus monkeys.
abstract: The purpose of the present study was to evaluate the effect of autogenous bone graft particles and expanded polytetrafluoroethylene (ePTFE) membrane in the treatment of peri-implantitis with stereologic and histologic methods. Clinical and radiographic findings are reported elsewhere. Experimental peri-implantitis with a bone loss of 4-6 mm was established during 14-22 months around 64 implants with a titanium plasma-sprayed (TPS) surface in eight cynomolgus monkeys (Macaca fascicularis). The defects were treated with autogenous bone+membrane (B+M), autogenous bone (B), membrane (M), or a conventional flap procedure (control) (C). The animals were killed 6 months after surgery. Healthy peri-implant tissue was established irrespective of the applied treatment procedure. However, the amount of bone (autogenous bone graft particles and regenerated bone) and re-osseointegration were significantly higher in defects treated with B+M as compared with the three other treatment modalities. A mean bone-to-implant contact of 45% was estimated within defects treated with B+M. The corresponding values for the B, M, and C groups were 22, 21, and 14%. The present study therefore demonstrates that autogenous bone graft particles covered by an ePTFE membrane is a useful surgical treatment procedure of experimental peri-implantitis around implants with a TPS surface in cynomolgus monkeys. Obviously, there is a background for long-term evaluation in humans.
authors.affiliation: Departments of Oral and Maxillofacial Surgery, School of Dentistry, University of Copenhagen and University Hospital (Rigshospitalet), Denmark. ss@ass.nja.dk
authors.forename: Søren
authors.initials: S
authors.lastname: Schou
authors.forename: Palle
authors.initials: P
authors.lastname: Holmstrup
authors.forename: Lene Theil
authors.initials: LT
authors.lastname: Skovgaard
authors.forename: Kaj
authors.initials: K
authors.lastname: Stoltze
authors.forename: Erik
authors.initials: E
authors.lastname: Hjørting-Hansen
authors.forename: Hans Jørgen G
authors.initials: HJ
authors.lastname: Gundersen
mesh_terms: D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology; D016025:Bone Transplantation; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D016557:Guided Tissue Regeneration, Periodontal; D007091:Image Processing, Computer-Assisted; D008252:Macaca fascicularis; D008567:Membranes, Artificial; D016348:Osseointegration / Q000502:physiology; D010518:Periodontitis / Q000473:pathology / Q000601:surgery*; D011138:Polytetrafluoroethylene; D012044:Regression Analysis; D013499:Surface Properties; D013524:Surgical Flaps; D014025:Titanium; D014182:Transplantation, Autologous
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene; D014025:Titanium