title: Synthesis and potent antileukemic activities of N-lactylsphingosine and N-lactyldihydrosphingosine.
abstract: N-(R)- and N-(S)-lactylsphingosine and their corresponding dihydrosphingosine derivatives were synthesized. The antileukemic activities of these compounds were measured by MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) assay in human leukemia HL-60 cells. N-(R)- and N-(S)-Lactylsphingosine displayed higher activities than N-acetylsphingosine (C2-ceramide, a well-known apoptosis inducer), and their dihydrosphingosine derivatives had slight activities.
authors.affiliation: Department of Applied & Bioapplied Chemistry, Graduate School of Engineering, Osaka City University, Sugimoto 3-3-138, Sumiyoshi-ku, Osaka 558-8585, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Azuma
authors.forename: Ryoko
authors.initials: R
authors.lastname: Takao
authors.forename: Keiji
authors.initials: K
authors.lastname: Shikata
authors.forename: Hayato
authors.initials: H
authors.lastname: Niiro
authors.forename: Taro
authors.initials: T
authors.lastname: Tachibana
authors.forename: Kenji
authors.initials: K
authors.lastname: Ogino
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017209:Apoptosis; D002518:Ceramides / Q000138:chemical synthesis* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002518:Ceramides; C476589:N-lactyldihydrosphingosine; C476588:N-lactylsphingosine; D013110:Sphingosine