title: A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster.
abstract: The Drosophila melanogaster gene Anaplastic lymphoma kinase (Alk) is homologous to mammalian Alk, which encodes a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs). In humans, the t(2;5) translocation, which involves the ALK locus, produces an active form of ALK, which is the causative agent in non-Hodgkin's lymphoma. The physiological function of the Alk RTK, however, is unknown. In this paper, we describe loss-of-function mutants in the Drosophila Alk gene that cause a complete failure of the development of the gut. We propose that the main function of Drosophila Alk during early embryogenesis is in visceral mesoderm development.
authors.affiliation: Umeå Center for Molecular Pathogenesis, Umeå University, Sweden.
authors.forename: Christina E
authors.initials: CE
authors.lastname: Lorén
authors.forename: Camilla
authors.initials: C
authors.lastname: Englund
authors.forename: Caroline
authors.initials: C
authors.lastname: Grabbe
authors.forename: Bengt
authors.initials: B
authors.lastname: Hallberg
authors.forename: Tony
authors.initials: T
authors.lastname: Hunter
authors.forename: Ruth H
authors.initials: RH
authors.lastname: Palmer
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004064:Digestive System / Q000196:embryology; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000196:embryology* / Q000201:enzymology / Q000235:genetics; D008648:Mesoderm / Q000166:cytology / Q000378:metabolism; D017354:Point Mutation; D011505:Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism*; D020794:Receptor Protein-Tyrosine Kinases
chemical_list: D029721:Drosophila Proteins; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases