A critical evaluation of the prothrombin time for monitoring oral anticoagulant therapy.
The Quick prothrombin time is the most common clotting test performed, principally for monitoring oral anticoagulant therapy. The International Normalized Ratio (INR) for comparing patient results from prothrombin time measurements and the International Standardized Index (ISI) for achieving greater consistency of results using different thromboplastins have made it possible to compare the results of vitamin K antagonist drug therapy that was impossible before the introduction of the INR and ISI. However, INR values obtained from the same patient plasma sample using different thromboplastins are significantly different. This is so even when the thromboplastins have nearly the same ISI values. We suggest that investigation of patient-specific differences can provide a means by which the INR discrepancies can be identified and understood and thus lead to better methods for monitoring oral anticoagulant therapy.
Jackson
Craig M
CM
HemoSaga Diagnostics Corp., San Diego, Calif. 92111-1105, USA. cjackso@san.rr.com
Esnouf
M Peter
MP
Lindahl
Tomas L
TL
D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D001777:Blood Coagulation / Q000502:physiology; D001779:Blood Coagulation Factors / Q000502:physiology; D001780:Blood Coagulation Tests; D016903:Drug Monitoring / Q000379:methods* / Q000592:standards; D006801:Humans; D019934:International Normalized Ratio; D011517:Prothrombin Time / Q000379:methods / Q000592:standards; D015203:Reproducibility of Results; D013925:Thromboplastin / Q000737:chemistry / Q000494:pharmacology; D014812:Vitamin K / Q000037:antagonists & inhibitors / Q000502:physiology
D000925:Anticoagulants; D001779:Blood Coagulation Factors; D014812:Vitamin K; D013925:Thromboplastin