Anthelmintic activity of 13-alkoxy milbemycin derivatives.
A number of 13-alkoxy milbemycin derivatives were synthesized to evaluate their anthelmintic activity. We report the strategy for developing a potent anthelmintic product, 13-[4-(N-methanesulfonyl-N-methylamino)-phenylethyloxy]milbemycin. The details of the structure-activity relationships of those derivatives are also discussed.
Sugiyama
Yoko
Y
Medicinal Chemistry Research Lab. and Intellectual Property Department Sankyo Co., Ltd., 2-58 Hiromachi 1-chome, Shinagawa-ku, Tokyo 140-8710, Japan.
Kobayashi
Makio
M
Saito
Akio
A
D000871:Anthelmintics / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018942:Macrolides; D013329:Structure-Activity Relationship
D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D018942:Macrolides; C027837:moxidectin