title: Class and subclass selection in parasite-specific antibody responses.
abstract: Antibodies are characteristically induced in many parasitic infection processes. The class and subclass of the antibody response is instrumental because each isotype has a distinct biological function. It is thus crucially important for an infected individual to mount the most appropriate secondary antibody response--that is the response that has the best chance of clearing the infection and/or controlling disease. This represents a fundamental of vaccine strategies. Immuno-epidemiological surveys and in vitro models of antibody production have helped to understand some of the goals which should be achieved when designing antiparasitic vaccines.
authors.affiliation: Groupe Immunité des Muqueuses et Agents pathogènes EA-3064, Faculté de Médecine, Université de Saint-Etienne, 15 rue Ambroise Paré, 42023 cedex 02, Saint-Etienne, France. olivier.garraud@univ-st-etienne.fr <olivier.garraud@univ-st-etienne.fr>
authors.forename: Olivier
authors.initials: O
authors.lastname: Garraud
authors.forename: Ronald
authors.initials: R
authors.lastname: Perraut
authors.forename: Gilles
authors.initials: G
authors.lastname: Riveau
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Nutman
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis* / Q000145:classification* / Q000276:immunology; D056890:Eukaryota / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000276:immunology; D016052:Protozoan Vaccines / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology / Q000502:physiology; D018418:Th2 Cells / Q000276:immunology / Q000502:physiology
chemical_list: D000913:Antibodies, Protozoan; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016052:Protozoan Vaccines