Graves' disease associated with anticardiolipin antibody positivity and acquired protein S deficiency.
A 33-year-old woman had experienced recurrent pregnancy loss. She had positive anticardiolipin antibody and protein S deficiency. Her pregnancy was managed with anticoagulant therapy and she delivered a healthy infant. Three years after delivery, she reported progressive sweating, tremor, tachycardia, and a 4-kg weight loss. She was diagnosed with Graves' disease. This is a rare case of combined anticardiolipin antibody positivity, acquired protein S deficiency, and Graves' disease.
Nakayama
Tomohiro
T
Division of Receptor Biology, Advanced Medical Research Center, Nihon University School of Medicine, Ooyaguchi-kamimachi 30-1, Itabashi-ku, Tokyo 173-8610, Japan. tnakayam@med.nihon-u.ac.jp
Yamamoto
Tatsuo
T
Kanmatsuse
Katsuo
K
Kokubun
Shinichiro
S
D000022:Abortion, Spontaneous / Q000150:complications / Q000276:immunology / Q000517:prevention & control; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D017153:Antibodies, Anticardiolipin / Q000097:blood / Q000276:immunology*; D000925:Anticoagulants / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000276:immunology*; D006801:Humans; D011239:Prednisolone / Q000627:therapeutic use; D011247:Pregnancy; D011256:Pregnancy Outcome; D018455:Protein S Deficiency / Q000150:complications / Q000276:immunology*
D000893:Anti-Inflammatory Agents; D017153:Antibodies, Anticardiolipin; D000925:Anticoagulants; D004365:Drugs, Chinese Herbal; C413220:toki-shakuyaku-san; D011239:Prednisolone