Anaphylaxis due to patent blue dye during lymphography, with negative skin prick test.
We report here a case of anaphylaxis due to patent blue dye, which was administered to an adult female during a lymphographic intraoperative procedure. The patient was not atopic, and other possible causes of anaphylaxis (anesthetics, latex) had been carefully excluded through routine tests. The skin-prick test and patch test carried out with patent blue (PB) dye were negative, but the intradermal test with 100 microliters of the dye showed a remarkable positivity. There was no available commercial, specific IgE assay for PB dye, but the negativity of prick tests would exclude the involvement of an IgE-mediated mechanism. We want to highlight the possible danger derived from a dye that is considered inert, and that is now increasingly being used in surgical procedures.
Crivellaro
Mariangiola
M
Allergy Service, Verona General Hospital, Italy.
Senna
Gianenrico
G
Dama
Annarita
A
Bonadonna
Patrizia
P
Passalacqua
Giovanni
G
D000707:Anaphylaxis / Q000139:chemically induced*; D001943:Breast Neoplasms / Q000601:surgery; D004396:Coloring Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008220:Lymphography / Q000009:adverse effects* / Q000379:methods; D008875:Middle Aged; D012394:Rosaniline Dyes / Q000009:adverse effects*; D021701:Sentinel Lymph Node Biopsy / Q000009:adverse effects* / Q000379:methods; D012882:Skin Tests
D004396:Coloring Agents; D012394:Rosaniline Dyes; C008769:sulfan blue