title: [Effect of low doses of phenozan on lactate dehydrogenase and microviscosity of microsomal membranes of brain cells in mice].
abstract: It was shown that low doses of phenozan (10(-17), 10(-14), 10(-11), 10(-5) mol/kg) caused changes in kinetic parameters Vmax, Km of LDG and microviscosity in various ranges of microsomal membranes of brain cells. It is suggested that the effect of phenozan on the structure of bilayer membrane is important for binding LDG with membranes.
authors.affiliation: Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119991 Russia. tresch@sky.chph.ras.ru
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Treshchenkova
authors.forename: A N
authors.initials: AN
authors.lastname: Goloshchapov
authors.forename: E B
authors.initials: EB
authors.lastname: Burlakova
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects*; D002462:Cell Membrane / Q000737:chemistry / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D008861:Microsomes / Q000737:chemistry / Q000187:drug effects*; D010666:Phenylpropionates / Q000494:pharmacology*; D014783:Viscosity / Q000187:drug effects
chemical_list: D010666:Phenylpropionates; D007770:L-Lactate Dehydrogenase; C047854:fenozan