title: Association of African genetic admixture with resting metabolic rate and obesity among women.
abstract: OBJECTIVE
  To investigate the role of genetic admixture in explaining phenotypic variation in obesity-related traits in a sample of African-American women (n = 145) and to determine significant associations between obesity traits and admixture genetic markers.
  
  
  METHODS
  Associations between genetic admixture and BMI, resting metabolic rate, fat mass, fat-free mass, and bone mineral density were tested using linear regression considering the estimation of admixture by 1) a maximum-likelihood approach (MLA) and 2) a Bayesian analysis.
  
  
  RESULTS
  Both the conservative MLA and the Bayesian approach support an association between African genetic admixture and BMI. Evidence for the associations of African genetic admixture with fat mass and fat-free mass was supported by the Bayesian analysis; the MLA supported an association with bone mineral density. When the individual ancestry informative markers that were used to estimate admixture were tested for associations with BMI, significant associations were identified in chromosomes 1, 11, and 12.
  
  
  CONCLUSIONS
  These results provide evidence supporting the application of admixture mapping methods to the identification of genes that result in higher levels of obesity among African-American women. Further research is needed to replicate and further explore these findings.
authors.affiliation: Department of Nutrition Sciences and the Clinical Nutrition Research Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. jose@uab.edu
authors.forename: José R
authors.initials: JR
authors.lastname: Fernández
authors.forename: Mark D
authors.initials: MD
authors.lastname: Shriver
authors.forename: T Mark
authors.initials: TM
authors.lastname: Beasley
authors.forename: Nashwa
authors.initials: N
authors.lastname: Rafla-Demetrious
authors.forename: Esteban
authors.initials: E
authors.lastname: Parra
authors.forename: Jeanine
authors.initials: J
authors.lastname: Albu
authors.forename: Barbara
authors.initials: B
authors.lastname: Nicklas
authors.forename: Alice S
authors.initials: AS
authors.lastname: Ryan
authors.forename: Paul M
authors.initials: PM
authors.lastname: McKeigue
authors.forename: Clive L
authors.initials: CL
authors.lastname: Hoggart
authors.forename: Roland L
authors.initials: RL
authors.lastname: Weinsier
authors.forename: David B
authors.initials: DB
authors.lastname: Allison
mesh_terms: D016632:Apolipoprotein A-I / Q000235:genetics; D001481:Basal Metabolism / Q000235:genetics*; D001499:Bayes Theorem; D044383:Black People / Q000235:genetics*; D001823:Body Composition; D015992:Body Mass Index; D015519:Bone Density / Q000235:genetics; D002153:Calorimetry, Indirect; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002881:Chromosomes, Human, Pair 12; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics; D006801:Humans; D016013:Likelihood Functions; D009765:Obesity / Q000235:genetics*; D010641:Phenotype; D001741:Black or African American
chemical_list: D016632:Apolipoprotein A-I; C454420:G-protein beta3 subunit; D005819:Genetic Markers; D020962:Heterotrimeric GTP-Binding Proteins