title: [Change in the level of inflammatory cytokines and their relationship to the indicator in evaluating renal tubules injury of urinary in neonates with asphyxia].
abstract: OBJECTIVE
  To explore the relationship between amount of inflammatory cytokines in urine and neonatal postasphyxia renal tubules injury.
  
  
  METHODS
  The level of inflammatory cytokines such as interleukin (IL-8, IL-6), tumor necrosis factor-alpha (TNF-alpha) and the indicators of evaluating renal tubules injury [N-acetyl-glucosaminidase(NAG), gamma-glutamyltranspeptidase (gamma-GT), beta(2)-microglobulin (beta(2)-MG)] in urine were detected in neonates with asphyxia.
  
  
  RESULTS
  Compared with control, the levels of IL-8, IL-6, TNF-alpha and NAG, gamma-GT, beta2-MG were obviously increased in mild asphyxia group. In severe asphyxia group, the parameters above were all significantly increased compared with mild asphyxia group and the control group. Within the asphyxia group, there were positive relationship between inflammatory cytokines and the indicator of evaluating renal tubules injury.
  
  
  CONCLUSIONS
  The asphyxia may induce systemic inflammatory response syndrome (SIRS), which result in postasphyxia renal injury in neonates. The level of inflammatory cytokines in urine may be used as the indicators of evaluating the severity of asphyxia and postasphyxia renal injury in neonates.
authors.affiliation: Department of Pediatrics, Affiliated Hospital, Luzhou Medical College, Luzhou 646000, Sichuan, China.
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Dong
authors.forename: Zhang-hua
authors.initials: ZH
authors.lastname: Tang
authors.forename: Hong-ying
authors.initials: HY
authors.lastname: Chen
authors.forename: Shu-qin
authors.initials: SQ
authors.lastname: Chen
authors.forename: Xing-yong
authors.initials: XY
authors.lastname: Wang
authors.forename: Sheng-hui
authors.initials: SH
authors.lastname: Wang
authors.forename: Xue-song
authors.initials: XS
authors.lastname: Zhai
authors.forename: Da-cheng
authors.initials: DC
authors.lastname: Xiao
mesh_terms: D000118:Acetylglucosaminidase / Q000378:metabolism; D001238:Asphyxia Neonatorum / Q000473:pathology / Q000652:urine*; D016022:Case-Control Studies; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation; D015850:Interleukin-6 / Q000652:urine*; D016209:Interleukin-8 / Q000652:urine*; D007684:Kidney Tubules / Q000378:metabolism* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000652:urine*; D001613:beta 2-Microglobulin / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D001613:beta 2-Microglobulin; D005723:gamma-Glutamyltransferase; C554782:gamma-glutamyltransferase, human; D000118:Acetylglucosaminidase