Gold(III) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells.
A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.
Che
Chi-Ming
CM
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong. cmche@hku.hk
Sun
Raymond Wai-Yin
RW
Yu
Wing-Yiu
WY
Ko
Chi-Bun
CB
Zhu
Nianyong
N
Sun
Hongzhe
H
D000970:Antineoplastic Agents / Q000737:chemistry / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D004247:DNA / Q000737:chemistry*; D005260:Female; D017612:Gold Compounds / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D011166:Porphyrins / Q000737:chemistry / Q000633:toxicity*; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology; D014407:Tumor Cells, Cultured; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000378:metabolism
D000970:Antineoplastic Agents; D017612:Gold Compounds; D011166:Porphyrins; D004247:DNA