Exact significance levels for the maximum chi(2) method of detecting recombination.
CONCLUSIONS
Maynard Smith's maximum chi(2) method is a useful tool for detecting recombination. Significance testing is usually carried out by random permutation, which may require a large amount of computer time. I describe an exact algorithm.


BACKGROUND
Matlab source code from http://www.bioc.cam.ac.uk/UTOs/howe/
Spencer
M
M
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, England. ms379@cam.ac.uk
D000465:Algorithms; D016009:Chi-Square Distribution; D003198:Computer Simulation; D020869:Gene Expression Profiling / Q000379:methods*; D014644:Genetic Variation; D016013:Likelihood Functions; D008957:Models, Genetic; D015233:Models, Statistical; D011995:Recombination, Genetic / Q000235:genetics*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA / Q000379:methods*