[Effect of dehydroepiandrosterone sulfate on stress reactivity: mu-opioid mechanism].
The dehydroepiandrosterone sulfate (DHEAS) effect on stress-reactivity and the role of mu-opioid receptors in it, were studied. The experiments were carried out in male rats. The shuttling in single or in multiple (19 days, for 1 hour a day) regimes served as the experimental stress influences. The estimation of stress-reactivity was carried out by the plasma corticosterone level. It had been shown that the subcutaneous injection of dehydroepiandrosterone sulfate in rats reduced the stress-induced increase in corticosterone levels under the multiple influences, whereas naltrexone (0.1 mg/kg, for 20 min before DHEAS injection) blocked this effect. There were no effects of DHEAS or naltrexone on corticosterone levels under the single stress influences.
Obut
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Institute of Physiology, Russian Acad. Med. Sci., 4 Timakov St., Novosibirsk 630117, Russia.
Ovsiukova
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MV
Cherkasova
O P
OP
D000818:Animals; D003345:Corticosterone / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate / Q000494:pharmacology*; D008297:Male; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010812:Physical Stimulation; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013312:Stress, Physiological / Q000097:blood / Q000378:metabolism*
D009292:Narcotic Antagonists; D017450:Receptors, Opioid, mu; D019314:Dehydroepiandrosterone Sulfate; D009271:Naltrexone; D003345:Corticosterone