Magnetic resonance studies of dissolving particulate solids.
Magnetic resonance methods have been used to elucidate the internal pore structure of particulate solids, in particular detergent tablets. Such information is essential to a comprehensive understanding of the dissolution characteristics of these materials and how this property is related to processing conditions during tablet formation. In particular 3-D images of porosity are produced and 2-D self-diffusion maps are acquired as a function of observation time, which enables pore size to be quantified as a function of position via the extracted surface-to-volume ratio of the pore space. These properties are determined as a function of processing parameters, in particular the compression force used in tablet formation.
Johns
M L
ML
Department of Chemical Engineering, University of Cambridge, Cambridge CB2 3RA, UK. mlj21@cheng.can.ac.uk
Gladden
L F
LF
D003902:Detergents; D004058:Diffusion; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D016062:Porosity
D003902:Detergents