title: A fast dose calculation method based on table lookup for IMRT optimization.
abstract: This note describes a fast dose calculation method that can be used to speed up the optimization process in intensity-modulated radiotherapy (IMRT). Most iterative optimization algorithms in IMRT require a large number of dose calculations to achieve convergence and therefore the total amount of time needed for the IMRT planning can be substantially reduced by using a faster dose calculation method. The method that is described in this note relies on an accurate dose calculation engine that is used to calculate an approximate dose kernel for each beam used in the treatment plan. Once the kernel is computed and saved, subsequent dose calculations can be done rapidly by looking up this kernel. Inaccuracies due to the approximate nature of the kernel in this method can be reduced by performing scheduled kernel updates. This fast dose calculation method can be performed more than two orders of magnitude faster than the typical superposition/convolution methods and therefore is suitable for applications in which speed is critical, e.g., in an IMRT optimization that requires a simulated annealing optimization algorithm or in a practical IMRT beam-angle optimization system.
authors.affiliation: Department of Radiation Oncology, Virginia Commonwealth University Health System, Box 980058, Richmond, VA 23298, USA. qwu@vcu.edu
authors.forename: Qiuwen
authors.initials: Q
authors.lastname: Wu
authors.forename: David
authors.initials: D
authors.lastname: Djajaputra
authors.forename: Marc
authors.initials: M
authors.lastname: Lauterbach
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Radhe
authors.initials: R
authors.lastname: Mohan
mesh_terms: D000465:Algorithms; D055592:Biophysical Phenomena; D001703:Biophysics; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods* / Q000706:statistics & numerical data; D012985:Software Design