[Effect of low doses of phenozan on lactate dehydrogenase and microviscosity of microsomal membranes of brain cells in mice].
It was shown that low doses of phenozan (10(-17), 10(-14), 10(-11), 10(-5) mol/kg) caused changes in kinetic parameters Vmax, Km of LDG and microviscosity in various ranges of microsomal membranes of brain cells. It is suggested that the effect of phenozan on the structure of bilayer membrane is important for binding LDG with membranes.
Treshchenkova
Iu A
IuA
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119991 Russia. tresch@sky.chph.ras.ru
Goloshchapov
A N
AN
Burlakova
E B
EB
D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects*; D002462:Cell Membrane / Q000737:chemistry / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D008861:Microsomes / Q000737:chemistry / Q000187:drug effects*; D010666:Phenylpropionates / Q000494:pharmacology*; D014783:Viscosity / Q000187:drug effects
D010666:Phenylpropionates; D007770:L-Lactate Dehydrogenase; C047854:fenozan