title: Primary bilateral adrenal intravascular large B-cell lymphoma associated with adrenal failure.
abstract: We report a rare case of bilateral primary adrenal non-Hodgkin's lymphoma with adrenal failure. A 66-year-old woman developed symptoms of adrenal failure. The cause of adrenal failure was suspected to be malignant lymphoma based on the high levels of serum soluble interleukin-2 receptor and LDH. Bilateral adrenalectomy was performed and pathological examination showed intravascular large B-cell lymphoma (IVL). Although complete remission was achieved, recurrence occurred three months later with brain metastases. IVL should be suspected in patients with bilateral adrenal tumors who present with rapidly progressive adrenal failure.
authors.affiliation: First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Fukushima
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Okada
authors.forename: Takahisa
authors.initials: T
authors.lastname: Tanikawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Onaka
authors.forename: Aya
authors.initials: A
authors.lastname: Tanaka
authors.forename: Takehiro
authors.initials: T
authors.lastname: Higashi
authors.forename: Junichi
authors.initials: J
authors.lastname: Tsukada
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000175:diagnosis; D000311:Adrenal Glands / Q000098:blood supply; D000309:Adrenal Insufficiency / Q000209:etiology*; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D019043:Vascular Neoplasms / Q000175:diagnosis