title: Somatosensory evoked potential and histopathological investigations in ischaemia-induced brain damage: effects of trimetazidine in rats.
abstract: We studied the protective effects of trimetazidine (TMZ) on brain damage by means of somatosensory evoked potentials (SEP) in rats. The TMZ group did not show any statistically significant difference from the control group with respect to SEPs. However, the percentage of cells with ischaemic cell damage in hippocampal regions was significantly smaller in the TMZ group than the control group. Trimetazidine reduced the number of damaged cells in the cerebral tissue during the ischaemia-reperfusion damage. It was suggested that higher doses of trimetazidine may further reduce the number of cells with ischaemic damage.
authors.affiliation: Pamukkale University, Medical School, Department of Neurology, Denizli, Turkey. aoguzhan@pamukkale.edu.tr
authors.forename: Atilla
authors.initials: A
authors.lastname: Oğuzhanoğlu
authors.forename: Tülay
authors.initials: T
authors.lastname: Kurt
authors.forename: Ragip
authors.initials: R
authors.lastname: Ortaç
authors.forename: Bülent
authors.initials: B
authors.lastname: Turman
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D016923:Cell Death / Q000187:drug effects; D016009:Chi-Square Distribution; D004195:Disease Models, Animal; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000517:prevention & control; D018709:Statistics, Nonparametric; D014292:Trimetazidine / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D018696:Neuroprotective Agents; D014665:Vasodilator Agents; D014292:Trimetazidine