Continuous flow reactors for drug discovery.
To develop a new generation of drugs, pharmaceutical companies need to be able to synthesize and screen novel chemicals with enhanced speed. New technology that would enable a cost-neutral increase in the number of potential drug candidates would provide a distinct competitive advantage. The miniaturisation of chemical reactors offers many fundamental and practical advantages of relevance to the pharmaceutical industry, which is constantly searching for controllable, information-rich, high-throughput and environmentally friendly methods of producing compounds with a high degree of chemical selectivity. This article reviews the current and future applications of micro reactors that could enhance the drug discovery process.
Watts
Paul
P
Department of Chemistry, University of Hull, Cottingham Road, Hull, UK HU6 7RX. P.Watts@hull.ac.uk
Haswell
Stephen J
SJ
D002626:Chemistry, Pharmaceutical / Q000639:trends*; D015195:Drug Design; D004345:Drug Industry; D023281:Genomics; D010455:Peptides / Q000138:chemical synthesis; D013329:Structure-Activity Relationship; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000639:trends
D010455:Peptides