title: Robust regression-based analysis of drug-nucleic acid binding.
abstract: Outlier detection can be very important in analyzing data from Scatchard plots. In this study, a robust (outlier-resistant) regression procedure was used in conjunction with a Scatchard plot to study the binding of the methylphenazinium cation with double-stranded DNA. The procedures, their results, and their advantages are discussed.
authors.affiliation: Graduate School of Management, Kent State University, Kent, OH 44242, USA. dbooth@kent.edu
authors.forename: David E
authors.initials: DE
authors.lastname: Booth
authors.forename: Kidong
authors.initials: K
authors.lastname: Lee
mesh_terms: D004247:DNA / Q000378:metabolism*; D008773:Methylphenazonium Methosulfate / Q000378:metabolism*; D015233:Models, Statistical; D012044:Regression Analysis
chemical_list: D008773:Methylphenazonium Methosulfate; D004247:DNA