title: Analysis of fMRI data by blind separation of data in a tiny spatial domain into independent temporal component.
abstract: Independent Component Analysis (ICA) is a promising tool for the analysis of functional magnetic resonance imaging (fMRI) time series. In these studies, mostly assumed is a spatially independent component map of fMRI data (spatial ICA). In this paper, we assume that the temporal courses of the signal and noises are independent within a Tiny spatial domain (temporal ICA). Then with fast-ICA algorithm, spatially neighboring fMRI data were blindly separated into several temporal courses and were preassumed to be formed by a signal time course and several noise time courses where the signal has the largest correlation coefficient with the reference signal. The final functional imaging was completed for the signals obtained from each voxel. Simulations showed that compared with the spatial ICA method, the new temporal ICA method is more effective than the spatial ICA in detecting weak signal in a fMRI dataset. As background noise, the simulations include simulated Gaussian noise and fMRI data without stimulation. Finally, vivo fMRI tests showed that the excited areas evoked by a visual stimuli are mainly in the region of the primary visual cortex and that evoked by auditory stimuli are mainly in the region of the primary temporal cortex.
authors.affiliation: School of Life Science and Technology, School of Applied Math., University of Electronic Science and Technology of China, Chengdu, PR China.
authors.forename: Huafu
authors.initials: H
authors.lastname: Chen
authors.forename: Dezhong
authors.initials: D
authors.lastname: Yao
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhuo
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D001921:Brain / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D013997:Time Factors