8-OH-DPAT suppresses the induction of LTP in brain slices of the rat lateral amygdala.
The effect of 8-OH-DPAT on the induction of long-term potentiation (LTP) in the lateral nucleus of the amygdala was investigated using rat horizontal brain slice preparations. Bath-applied 8-OH-DPAT decreased the field potential amplitudes in a dose-dependent manner. In the lateral amygdala synapses, 8-OH-DPAT significantly suppressed the induction of LTP evoked by a weak theta burst stimulation. This suppression of LTP was also found using a concentration of 8-OH-DPAT, which did not influence the baseline activity significantly. The specific 5-HT(1A) receptor antagonist, WAY 100,635 blocked the inhibitory effect of 8-OH-DPAT on the induction of LTP. The inhibitory effect of 5-HT(1A) receptor stimulation on amygdaloid neuronal plasticity suggests that the amygdala is a site for serotonin to exert its influence on memory of aversive events.
Pollandt
Sebastian
S
Johannes Müller Institute of Physiology, Faculty of Medicine (Charité), Humboldt University, Tucholskystr. 2, 10117 Berlin, Germany.
Drephal
Christian
C
Albrecht
Doris
D
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000679:Amygdala / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D000818:Animals; D005260:Female; D017774:Long-Term Potentiation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects
D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin