Renal aquaporins and sodium transporters with special focus on urinary tract obstruction.
The discovery of aquaporin-1 (AQP1) by Agre and colleagues explained the long-standing biophysical question of how water specifically crosses biological membranes. These studies led to the discovery and identification of a whole new family of membrane proteins, the aquaporins. At present, at least seven aquaporins are expressed at distinct sites in the kidney and 4 members of this family (AQP1-4) have been demonstrated to play pivotal roles in the physiology and pathophysiology for renal regulation of body water balance. Osmotic equilibration via renal aquaporins is maintained by active transport of NaCl. The major sodium transporters and channels in the individual renal tubule segments have been identified and the regulation of these transporters and channels are fundamental for renal sodium reabsorption and for establishing the driving force. In this mini-review the role of renal aquaporins and sodium transporters and channels is briefly described and their key role for the impaired urinary concentrating capacity in response to urinary tract obstruction is reviewed. Thus this review updates previous detailed reviews (1-5).
Frøkiaer
Jørgen
J
Institute of Experimental Clinical Research, Water and Salt Research Centre, University of Aarhus, Denmark. JF@IEKF.AU.DK
Li
Chunling
C
Shi
Yimin
Y
Jensen
Anja
A
Praetorius
Helle
H
Hansen
Helle
H
Topcu
Oguz
O
Sardeli
Chrysanthi
C
Wang
Weidong
W
Kwon
Tae-Hwan
TH
Nielsen
Søren
S
D000818:Animals; D020346:Aquaporins / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D015222:Sodium Channels / Q000502:physiology*; D014570:Urologic Diseases / Q000503:physiopathology*; D014867:Water / Q000502:physiology
D020346:Aquaporins; D015222:Sodium Channels; D014867:Water