title: A retrospective examination of anemia during infection of humans with Plasmodium vivax.
abstract: A retrospective examination was made of archival data on 98 patient episodes of infection with Plasmodium vivax occurring over a period of 4-11 weeks to document changes in hemoglobin (Hb) concentrations associated with continuing parasitemia. The mean percentage change in the Hb concentration for each of the 10 seven-day intervals was -13.4, -10.9, -4.8, 0.12, 0.94, 4.0, 0.69, 11.6, 2.4, and 8.3, respectively. An equilibrium appeared to be established between weeks 4 and 6. Decreases in Hb concentrations were greatest following the first week of parasitemia. Total restoration to preinfection levels did not occur during persistent parasitemia.
authors.affiliation: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA. wec1@cdc.gov
authors.forename: William E
authors.initials: WE
authors.lastname: Collins
authors.forename: Geoffrey M
authors.initials: GM
authors.lastname: Jeffery
authors.forename: Jacquelin M
authors.initials: JM
authors.lastname: Roberts
mesh_terms: D000740:Anemia / Q000097:blood / Q000209:etiology*; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000737:chemistry / Q000469:parasitology / Q000473:pathology*; D006454:Hemoglobins / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D016014:Linear Models; D016780:Malaria, Vivax / Q000097:blood / Q000150:complications*; D009494:Neurosyphilis / Q000628:therapy; D018512:Parasitemia / Q000097:blood / Q000150:complications*; D012189:Retrospective Studies
chemical_list: D006454:Hemoglobins