Congenitally determined neurodegeneration "Lurcher" induces morphofunctional changes of thymus.
A significantly higher frequency of apoptosis was documented by flow cytometry and by ELISA analysis, and significantly higher numbers of necrotic cells were demonstrated by ELISA within the thymus of Lurcher mice in comparison with the control C3H mice. These can be regarded as important markers of degenerative changes in this primary immune organ. This tendency is supported by histological observation of the absence of a clear interface between thymic cortex and medulla and an insignificantly increased number of Hassall's corpuscles resembling an onset of thymic atrophy.
Mandáková
P
P
Department of Pathology and Molecular Medicine, University Hospital Motol, Prague, Czechia.
Virtová
M
M
Síma
P
P
Beranová
M
M
Slípka
J
J
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D051379:Mice; D008809:Mice, Inbred C3H; D008818:Mice, Neurologic Mutants; D009336:Necrosis; D009410:Nerve Degeneration / Q000473:pathology*; D013950:Thymus Gland / Q000473:pathology*