title: Pyrrolo[2,3-h]quinolinones: synthesis and photochemotherapic activity.
abstract: A series of derivatives of the new ring system pyrrolo[2,3-h]quinoline-2-one was synthesized and evaluated as photoreagents toward cultured human tumor cells. Remarkable phototoxycity resulted for some derivatives, especially those bearing the phenyl group at the 7-position.
authors.affiliation: Dipartimento Farmacochimico, Tossicologico e Biologico Università degli Studi, Via Archirafi 32, 90123 Palermo, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Barraja
authors.forename: Patrizia
authors.initials: P
authors.lastname: Diana
authors.forename: Antonino
authors.initials: A
authors.lastname: Lauria
authors.forename: Alessandra
authors.initials: A
authors.lastname: Montalbano
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Almerico
authors.forename: Gaetano
authors.initials: G
authors.lastname: Dattolo
authors.forename: Girolamo
authors.initials: G
authors.lastname: Cirrincione
authors.forename: Giampietro
authors.initials: G
authors.lastname: Viola
authors.forename: Francesco
authors.initials: F
authors.lastname: Dall'Acqua
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005354:Fibrosarcoma; D006801:Humans; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D011758:Pyrroles; D015363:Quinolones