title: Relationship between airway hyperresponsiveness to mannitol and adenosine monophosphate.
abstract: BACKGROUND
  Assessment of airway hyperresponsiveness (AHR) to indirect bronchoconstrictor stimuli is a useful noninvasive tool in the evaluation of asthma and its treatment. We investigated the putative relationship in AHR between inhaled adenosine monophosphate and mannitol.
  
  
  METHODS
  Fifteen mild-to-moderate atopic asthmatics were evaluated. On two separate screening days, the threshold AMP concentration and threshold mannitol dose to provoke a given fall in FEV1 were measured.
  
  
  RESULTS
  For AMP PC20vs. mannitol PD15, the Pearsons correlation coefficient was 0.80, P < 0.001. For AMP PC15vs. mannitol PD15 and AMP PC10vs. mannitol PD10 corresponding values were 0.83, P < 0.001 and 0.68, P = 0.005.
  
  
  CONCLUSIONS
  There was a highly significant association between the threshold concentration of AMP and dose of mannitol causing a given fall in FEV1. Further studies are required to evaluate the relationship between inhaled mannitol and other surrogate inflammatory markers.
authors.affiliation: Asthma and Allergy Research Group, Ninewells University Hospital and Medical School, Dundee, UK.
authors.forename: G P
authors.initials: GP
authors.lastname: Currie
authors.forename: K
authors.initials: K
authors.lastname: Haggart
authors.forename: J D
authors.initials: JD
authors.lastname: Brannan
authors.forename: D K C
authors.initials: DK
authors.lastname: Lee
authors.forename: S D
authors.initials: SD
authors.lastname: Anderson
authors.forename: B J
authors.initials: BJ
authors.lastname: Lipworth
mesh_terms: D000249:Adenosine Monophosphate; D000328:Adult; D000336:Aerosols; D001249:Asthma / Q000175:diagnosis / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000175:diagnosis*; D001985:Bronchial Provocation Tests; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008353:Mannitol; D008875:Middle Aged; D011208:Powders; D013147:Spirometry
chemical_list: D000336:Aerosols; D011208:Powders; D008353:Mannitol; D000249:Adenosine Monophosphate