title: Protective efficacy of a live attenuated anti-coccidial vaccine administered to 1-day-old chickens.
abstract: The efficacy of a live attenuated anti-coccidial vaccine, Paracox-5, administered to 1-day-old chicks was investigated by assessing protection against changes in weight gain following virulent challenge. Vaccinated birds were challenged independently 28 days later with each of the component species (Eimeria acervulina, Eimeria maxima, Eimeria mitis or Eimeria tenella), and protection was demonstrated against associated reduction in weight gain and lesion formation. In addition, an improvement in bird performance, in terms of feed conversion ratio, was also observed following vaccination. Furthermore, under conditions designed to more closely mimic those in the field and using hatchery spray administration, protection against a mixed virulent challenge introduced by 'seeder birds' was demonstrated evenly across a flock of broiler birds within 21 days after vaccination. These data demonstrate that Paracox-5 vaccine will protect broiler chickens against the adverse effects on performance induced by Eimeria spp.
authors.affiliation: Schering-Plough Animal Health Breakspear Road South Harefield, Uxbridge UB9 6LS Middlesex, UK. colin.crouch@spcorp.com
authors.forename: C F
authors.initials: CF
authors.lastname: Crouch
authors.forename: S J
authors.initials: SJ
authors.lastname: Andrews
authors.forename: R G
authors.initials: RG
authors.lastname: Ward
authors.forename: M J
authors.initials: MJ
authors.lastname: Francis
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D002645:Chickens / Q000276:immunology / Q000469:parasitology; D003048:Coccidiosis / Q000276:immunology* / Q000517:prevention & control* / Q000662:veterinary; D004539:Eimeria / Q000276:immunology*; D011201:Poultry Diseases / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control*; D016052:Protozoan Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology*; D015430:Weight Gain
chemical_list: D016052:Protozoan Vaccines; D014613:Vaccines, Attenuated