Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices.
The structure of scleroglucan gel matrices was characterized by dynamic rheological studies. The results were compared with the release kinetics of theophylline in analogous samples using a Franz diffusion cell, fitting the drug release data with a semi-empirical power law. Dynamic rheology gave information about the viscous and elastic components (loss and storage moduli, respectively) of the gel which could influence the drug-release profiles. Scleroglucan gels showed two structural transitions within the gel regime that coincided with changes in the release pattern. It was found that the introduction of 0.4% (w/w) of theophylline decreased the loss and storage moduli in the 2% (w/w) scleroglucan gels by 50%. The influence of the same wt.% theophylline in other gels was strongly dependent on the gel concentration. These results demonstrated the value of rheological studies to detect matrix structural changes produced by the inclusion of drugs which may modify the drug-release profile.
François
Nora J
NJ
Laboratorio de Química de Sistemas Heterogéneos, Facultad de Ingeniería, Universidad de Buenos Aires, Paseo Colón 850, C1063ACV Buenos Aires, Argentina.
Rojas
Ana María
AM
Daraio
Marta E
ME
Bernik
Delia L
DL
D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004339:Drug Compounding; D005782:Gels / Q000008:administration & dosage / Q000737:chemistry*; D005936:Glucans / Q000008:administration & dosage / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D012212:Rheology; D013806:Theophylline / Q000008:administration & dosage / Q000737:chemistry; D013997:Time Factors; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000737:chemistry
D004337:Drug Carriers; D005782:Gels; D005936:Glucans; D014665:Vasodilator Agents; C045938:scleroglucan; D013806:Theophylline