Cocaine induces a dose-dependent alteration in the expression of immediate early genes c-fos and SP-1 and in nuclear factor NF-kappabeta in PC12 cells.
Imam
Syed Z
SZ
Division of Neurotoxicology, US FDA/NCTR, Jefferson, Arkansas 72079, USA.
Duhart
Helen M
HM
Skinner
John T
JT
Ali
Syed F
SF
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation / Q000187:drug effects; D016762:Genes, fos; D016328:NF-kappa B / Q000235:genetics*; D016716:PC12 Cells; D051381:Rats; D016329:Sp1 Transcription Factor / Q000235:genetics*
D018765:Dopamine Uptake Inhibitors; D016328:NF-kappa B; D016329:Sp1 Transcription Factor; D003042:Cocaine; D004298:Dopamine