Secreted effector proteins of Salmonella enterica serotype typhimurium elicit host-specific chemokine profiles in animal models of typhoid fever and enterocolitis.
Infection of bovine ligated loops with the Salmonella enterica serotype Typhimurium wild type but not a sipA sopABDE2 mutant resulted in fluid accumulation, polymorphonuclear cell infiltration, and expression of CXC chemokines, particularly GRO alpha. None of these sipA sopABDE2-dependent responses was observed in murine-ligated loops. The majority of GRO alpha transcripts localized to bovine intestinal epithelium. Thus, different disease outcomes between mice (i.e., no diarrhea) and calves (i.e., diarrhea) may be due to differences in sipA sopABDE2-dependent CXC chemokine gene expression in epithelial cells.
Zhang
Shuping
S
Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4467, USA.
Adams
L Garry
LG
Nunes
Jairo
J
Khare
Sangeeta
S
Tsolis
Renée M
RM
Bäumler
Andreas J
AJ
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D001483:Base Sequence; D002417:Cattle; D054360:Chemokine CXCL1; D018925:Chemokines / Q000235:genetics; D019743:Chemokines, CXC / Q000235:genetics*; D002630:Chemotactic Factors / Q000235:genetics; D004247:DNA / Q000235:genetics; D004195:Disease Models, Animal; D004760:Enterocolitis / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D015870:Gene Expression; D005798:Genes, Bacterial; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D051379:Mice; D008840:Microfilament Proteins / Q000235:genetics; D009154:Mutation; D010581:Peyer's Patches / Q000276:immunology; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012486:Salmonella typhimurium / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D013045:Species Specificity; D014435:Typhoid Fever / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D014774:Virulence / Q000235:genetics / Q000502:physiology
D001426:Bacterial Proteins; C475896:CXCL1 protein, Bos taurus; C475829:CXCL1 protein, human; D054360:Chemokine CXCL1; D018925:Chemokines; D019743:Chemokines, CXC; D002630:Chemotactic Factors; C475895:Cxcl1 protein, mouse; D020662:Guanine Nucleotide Exchange Factors; D036341:Intercellular Signaling Peptides and Proteins; D008840:Microfilament Proteins; D012333:RNA, Messenger; C118287:SipA protein, Salmonella; C060972:SopB protein, Bacteria; C116105:SopD protein, Salmonella; C436324:SopE2 protein, Salmonella typhimurium; D004247:DNA; D010744:Phosphoric Monoester Hydrolases; C489224:SopB protein, Salmonella