title: Turbinatine, a potential key intermediate in the biosynthesis of corynanthean-type indole alkaloids.
abstract: Extraction of the leaves of Chimarrhis turbinata has led to the isolation of turbinatine (1), a new corynanthean-type indole alkaloid, besides four known indole alkaloids, strictosidine, 5alpha-carboxystrictosidine, vallesiachotamine, and isovallesiachotamine. The structural determination of 1 was based on 1D and 2D spectroscopic data. An evaluation of the DNA-damaging activities of the isolates was performed by means of a bioassay using mutant strains of Saccharomyces cerevisiae, which indicated these compounds were weakly active.
authors.affiliation: Instituto de Química, Universidade Estadual Paulista, UNESP, CP 355, CEP 14-801-970, Araraquara, São Paulo, Brazil.
authors.forename: Carmen Lucia
authors.initials: CL
authors.lastname: Cardoso
authors.forename: Dulce Helena
authors.initials: DH
authors.lastname: Siqueira Silva
authors.forename: Daniela Maria
authors.initials: DM
authors.lastname: Tomazela
authors.forename: Hugo
authors.initials: H
authors.lastname: Verli
authors.forename: Maria Claudia Marx
authors.initials: MC
authors.lastname: Young
authors.forename: Maysa
authors.initials: M
authors.lastname: Furlan
authors.forename: Marcos Nogueira
authors.initials: MN
authors.lastname: Eberlin
authors.forename: Vanderlan
authors.initials: V
authors.lastname: da Silva Bolzani
mesh_terms: D001938:Brazil; D004249:DNA Damage; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D019666:Rubiaceae / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects*
chemical_list: D026121:Indole Alkaloids; C480066:turbinatine