Effects of fucoidan on chronic renal failure in rats.
The effects of fucoidan on chronic renal failure (CRF) were investigated in vivo in a subtotal nephrectomy CRF model and a cryoinjury induced CRF model in rats. Fucoidan showed renoprotective effects in both models. Fucoidan (100 or 200 mg/kg, orally) significantly decreased elevated serum creatinine and urea nitrogen levels. Histopathological changes of renal tubules and interstitium were markedly alleviated by fucoidan and the mesangial areas were also greatly reduced. The activities of fucoidan were dose-dependent.
Zhang
Quanbin
Q
Institute of Oceanology, Chinese Academy of Sciences, Qingdao, P. R. China.
Li
Zhien
Z
Xu
Zuhong
Z
Niu
Xizhen
X
Zhang
Hong
H
D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001783:Blood Flow Velocity; D001806:Blood Urea Nitrogen; D004195:Disease Models, Animal; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000293:injuries; D007676:Kidney Failure, Chronic / Q000517:prevention & control; D007795:Laminaria; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012077:Renal Artery / Q000502:physiology*
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D011134:Polysaccharides; C007789:fucoidan