title: Topical mitomycin C-induced inhibition of postlaminectomy peridural fibrosis in rabbits.
abstract: OBJECTIVE
  The authors conducted a study to determine the effectiveness of mitomycin C in preventing postlaminectomy peridural fibrosis in rabbits.
  
  
  METHODS
  Laminectomies were performed at L-4 in 12 rabbits. Color-coded cotton pads soaked either with 0.02% mitomycin C or saline were applied in a blinded fashion to the operative sites, with saline-treated laminectomy sites serving as controls. The rabbits were killed 30 days after surgery. The extent of peridural fibrosis was evaluated by histological analysis. The mitomycin C-treated sites showed significantly decreased peridural fibrosis.
  
  
  CONCLUSIONS
  Peridural fibrosis can be a devastating condition that develops after laminectomy. Topical application of mitomycin C may be a successful method of preventing postlaminectomy peridural fibrosis.
authors.affiliation: Department of Neurosurgery, Gazi University School of Medicine, Ankara, Turkey. fdogulu@hotmail.com
authors.forename: Fikret
authors.initials: F
authors.lastname: Dogulu
authors.forename: Gokhan
authors.initials: G
authors.lastname: Kurt
authors.forename: Hakan
authors.initials: H
authors.lastname: Emmez
authors.forename: Ozlem
authors.initials: O
authors.lastname: Erdem
authors.forename: Leyla
authors.initials: L
authors.lastname: Memis
authors.forename: Kemali
authors.initials: K
authors.lastname: Baykaner
authors.forename: Necdet
authors.initials: N
authors.lastname: Ceviker
mesh_terms: D000287:Administration, Topical; D000477:Alkylating Agents / Q000008:administration & dosage*; D000818:Animals; D004388:Dura Mater; D005260:Female; D005355:Fibrosis / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D007796:Laminectomy / Q000009:adverse effects*; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D011817:Rabbits
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin