Visible light-induced nuclease activity of a ternary mono-phenanthroline copper(II) complex containing L-methionine as a photosensitizer.
Ternary copper(II) complex, structurally characterized as [Cu(phen)(met)(MeOH)](ClO4) (1) by X-ray crystallography, has 1,10-phenanthroline (phen) as an intercalator/binder to supercoiled pUC19 DNA and L-methionine (met) as a photosensitizer, and the complex displays efficient photonuclease activity on irradiation with UV (312 nm) or visible (436, 532 nm) light through a mechanistic pathway involving singlet oxygen.
Patra
Ashis K
AK
Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-560012, India.
Dhar
Shanta
S
Nethaji
Munirathinam
M
Chakravarty
Akhil R
AR
D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D003851:Deoxyribonucleases / Q000737:chemistry / Q000378:metabolism; D004789:Enzyme Activation / Q000502:physiology; D008027:Light; D008715:Methionine / Q000737:chemistry* / Q000378:metabolism; D010618:Phenanthrolines / Q000737:chemistry* / Q000378:metabolism; D017319:Photosensitizing Agents / Q000737:chemistry / Q000378:metabolism
D010618:Phenanthrolines; D017319:Photosensitizing Agents; D003300:Copper; D008715:Methionine; D003851:Deoxyribonucleases