Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues.
An array of 4-(aryl or indolyl)pyrrolo[3,4-c]carbazole-1,3-diones (open analogues of indolocarbazole alkaloids), 10-(aryl or indolyl)pyrrolo[3,4-b]carbazole-1,3-diones, and different derivatives have been prepared using a Diels-Alder plus Fischer indolization approach and tested as cytotoxic agents. Some representative compounds display interesting cytotoxic profiles.
Caballero
Esther
E
Laboratorio de Qui;mica Orgánica y Farmacéutica, Facultad de Farmacia, 37007, Salamanca, Spain. escab@usal.es
Adeva
Marta
M
Calderón
Suzanne
S
Sahagún
Heidi
H
Tomé
Fernando
F
Medarde
Manuel
M
Fernández
José Luis
JL
López-Lázaro
Miguel
M
Ayuso
Maria Jesús
MJ
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure
D000470:Alkaloids