title: Clinical relevance of antiprothrombin antibodies.
abstract: Antiprotrombin antibodies belong to the family of antiphospholipid antibodies (aPLs). The clinical relevance of antiprothrombin antibodies has not been established and it depends on the applied detection method. Antibodies against phosphatidylserine-prothrombin complex (aPS/PT) are closely associated with clinical features of antiphospholipid syndrome (APS) and lupus anticoagulant rather than antibodies against prothrombin alone. The determination of aPS/PT in routine clinical practice should be done in conjunction with other aPLs detection to improve the likelihood of recognising the APS, which would ultimately facilitate the management of the disease.
authors.affiliation: Department of Medicine II, Hokkaido University School of Medicine, N15 W7, Kita-ku, Sapporo 060-8638, Japan. at3at@med.hokudai.ac.jp
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Atsumi
authors.forename: Takao
authors.initials: T
authors.lastname: Koike
mesh_terms: D000022:Abortion, Spontaneous / Q000188:drug therapy; D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000918:Antibody Specificity; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006023:Glycoproteins / Q000097:blood / Q000276:immunology; D006801:Humans; D011247:Pregnancy; D011516:Prothrombin / Q000276:immunology*; D013927:Thrombosis / Q000175:diagnosis / Q000276:immunology; D053482:beta 2-Glycoprotein I
chemical_list: D000906:Antibodies; D006023:Glycoproteins; D053482:beta 2-Glycoprotein I; D011516:Prothrombin