title: Total synthesis of (+/-)-spiroxin C.
abstract: [reaction: see text] The first total synthesis of a marine-derived potent antitumor antibiotic, (+/-)-spiroxin C, was achieved via a TBAF-activated Suzuki-Miyaura cross-coupling reaction as a key step, which was also shown to be useful for the synthesis of sterically hindered binaphthyl derivatives.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Miyashita
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sakai
authors.forename: Takeshi
authors.initials: T
authors.lastname: Imanishi
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000903:Antibiotics, Antineoplastic; D009281:Naphthalenes; D013141:Spiro Compounds; C478427:spiroxin C; D010165:Palladium