title: Synthesis and biological evaluation of gambierol analogues.
abstract: Gambierol is a polycyclic ether toxin, isolated as a toxic constituent from the marine dinoflagellate Gambierdiscus toxicus. We describe here the synthesis and biological evaluation of structural analogues of gambierol. The present preliminary structure-activity relationship studies clearly indicate that the H ring functionality and the unsaturated side chain of gambierol are crucial for its potent toxicity.
authors.affiliation: Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Fuwa
authors.forename: Noriko
authors.initials: N
authors.lastname: Kainuma
authors.forename: Masayuki
authors.initials: M
authors.lastname: Satake
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D002922:Ciguatoxins / Q000138:chemical synthesis* / Q000633:toxicity*; D004141:Dinoflagellida / Q000737:chemistry*; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000633:toxicity*; D007202:Indicators and Reagents; D007928:Lethal Dose 50; D051379:Mice; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000633:toxicity*; D013329:Structure-Activity Relationship; D035964:Oxocins
chemical_list: D002922:Ciguatoxins; D004988:Ethers, Cyclic; D007202:Indicators and Reagents; D011083:Polycyclic Compounds; C435770:gambierol; D035964:Oxocins