title: [Use of platelet-rich plasma in major maxillary sinus augmentation].
abstract: OBJECTIVE
  Platelet-rich plasma (PRP) is a solution, usually in the form of a gel, with a high concentration of platelets (equal to double or three-fold normal reference values). This preparation also contains a high concentration of fibrinogen, a fundamental element for the release of numerous polypeptides (complementary factors) and above all for the induction of platelet degranulation and the consequent release of growth factors, which interact in a highly positive fashion with the bone metabolism at the host site. The biological benefit that PRP can give to tissues treated with the technique of major maxillary sinus augmentation thus appears undoubted.
  
  
  METHODS
  The series reported consists of 3 patients who were treated by major augmentation of the maxillary sinus associated with the use of a mixture consisting of PRP, beta-tricalcium phosphate (Cerasorb ) and autologous bone tissue.
  
  
  RESULTS
  All the patients were successfully treated and it was possible to detect tissue regeneration both horizontally and vertically (approximately 4 mm), with formation of high quality bone tissue, which subsequently enabled optimal osseointegration of the implants inserted.
  
  
  CONCLUSIONS
  The introduction of PRP into the field of regenerative techniques has opened new horizons, especially in the branch of implantology. This mixture is able to reduce the quantity of autologous tissue harvested. The gel-like consistency also avoids the application and subsequent removal of a membrane, and in consequence the surgical trauma undergone by the patient is markedly reduced.
authors.affiliation: Cattedra di Chirurgia Maxillo-Facciale, Università degli Studi di Perugia, Perugia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Moro
authors.forename: V
authors.initials: V
authors.lastname: Casini
authors.forename: A
authors.initials: A
authors.lastname: Bastieri
mesh_terms: D001792:Blood Platelets / Q000378:metabolism; D001861:Bone Regeneration; D016025:Bone Transplantation; D002130:Calcium Phosphates; D015921:Dental Implants; D005260:Female; D005340:Fibrinogen; D005782:Gels; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000601:surgery*; D016348:Osseointegration; D010949:Plasma; D016896:Treatment Outcome
chemical_list: D002130:Calcium Phosphates; D015921:Dental Implants; D005782:Gels; D006133:Growth Substances; C485817:beta-tricalcium phosphate; D005340:Fibrinogen; C018392:tricalcium phosphate