The role of c-Jun N-terminal kinase (JNK) in Parkinson's disease.
Given the critical role that the c-Jun N-terminal kinase (JNK) pathway plays in regulating many of the cellular processes which are affected in Parkinson's disease (PD), the possible importance of JNK in disease pathogenesis is being increasingly recognized. Here we review recent findings implicating the JNK signaling pathway in animal models of Parkinson's disease and discuss the relationship between this pathway and the prominent pathological processes observed in the disease state. We suggest that regulation of the JNK signaling pathway may be a central facet in potential treatments for the disease.
Peng
Jun
J
Buck Institute for Age Research, 8001 Redwood Blvd, Novato, CA 94945, USA.
Andersen
Julie K
JK
D000818:Animals; D017209:Apoptosis; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000201:enzymology; D010300:Parkinson Disease / Q000201:enzymology* / Q000473:pathology; D015398:Signal Transduction
D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases