title: Determination of volatile residual solvents in traditional Chinese medicines by headspace solid-phase microextraction and cryogenic gas chromatography with flame ionization detection.
abstract: A method based on headspace solid-phase microextraction and cryogenic gas chromatography with flame ionization detection was developed for the determination of volatile residual solvents in traditional Chinese medicines. A laboratory-made cryogenic chromatographic system was used for the separation of 15 kinds of residual solvents. During the analysis, a 65 microm PDMS/DVB fiber was used to extract the residual solvents, the extraction time was controlled at 0 degrees C for 15 min, and the NaCl content of the sample was maintained at 30%. The limits of detection ranged from 0.08 (for octane) to 5000 microg/L (for ethanol), and the relative standard deviations were < 8%. The recoveries from spiked samples ranged from 88 to 112%. Trace levels of residual solvents in several traditional Chinese medicines were effectively identified and quantified.
authors.affiliation: Chinese Academy of Sciences, Research Center for Eco-Environmental Sciences, PO Box 2871, Beijing 100085, People's Republic of China.
authors.forename: Jiemin
authors.initials: J
authors.lastname: Liu
authors.forename: Qunfang
authors.initials: Q
authors.lastname: Zhou
authors.forename: Guibin
authors.initials: G
authors.lastname: Jiang
authors.forename: Jingfu
authors.initials: J
authors.lastname: Liu
authors.forename: Jiyan
authors.initials: J
authors.lastname: Liu
authors.forename: Meijuan
authors.initials: M
authors.lastname: Wen
mesh_terms: D002138:Calibration; D002849:Chromatography, Gas; D005410:Flame Ionization; D008516:Medicine, Chinese Traditional; D012997:Solvents / Q000032:analysis*
chemical_list: D012997:Solvents