Cystic fibrosis: can epithelial function be restored?
The treatment of cystic fibrosis (CF) is still very much concerned with alleviating its symptoms. However, despite the considerable increase in the knowledge of the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, no magic bullet for the treatment of CF is in sight. This review focuses on what is known about the ion transport defect and which pharmacological and molecular approaches have the greatest potential to provide a cure in the future.
Trapp
Stefan
S
Royal Free & University College Medical School, Rowland Hill Street, London, NW3 2PF, UK. s.trapp@rfc.ucl.ac.uk