title: [Spectrum of psychotropic effects and mechanism of action of ultra low doses of the antibodies to S-100 protein (proproten)].
abstract: Proproten contains ultra-low doses of affinity purified antibodies to S-100 protein dynamized according to the rules of homeopathy. S-100 is regulator of brain integrative activity and takes part in synaptic processes. In experiment on outbred rats proproten demonstrates significant anxiolytic, antidepressant and antiamnestic effects after single and repeated administration. Proproten is similar to the well-known reference preparations diazepam, amitriptyline and piracetam in activity. Proporten's advantage over these drugs is no sedative, myorelaxation and amnestic effects. Psychotropic effects of proproten are likely to result from modulation of synaptic transmission in limbic structures of brain.
authors.affiliation: Institute of Pharmacology, Russian Academy of Medical Sciences, Materia Medica Holding Scientific and Production Company, Moscow, Russia.
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
authors.forename: O I
authors.initials: OI
authors.lastname: Epshteĭn
authors.forename: G M
authors.initials: GM
authors.lastname: Molodavkin
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
authors.forename: V A
authors.initials: VA
authors.lastname: Kraĭneva
mesh_terms: D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D010889:Piracetam / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D009418:S100 Proteins / Q000187:drug effects / Q000276:immunology*
chemical_list: D000906:Antibodies; D000928:Antidepressive Agents; D011619:Psychotropic Drugs; D009418:S100 Proteins; D000639:Amitriptyline; D003975:Diazepam; D010889:Piracetam