title: Therapeutic potential of the plasma proteome.
abstract: Plasma contains numerous and diverse proteins with existing and potential therapeutic value. Plasma has been used clinically as both a source of purified derivatives for treating diseases such as hemophilia, and as a diagnostic medium. Recent research directed towards mining plasma's true potential takes advantage of state-of-the-art proteomic analytical methods to develop multi-protein, disease-specific biomarker panels to improve the reliability and specificity of diagnostics. Recombinant production and chromatographic purification methods are increasing the yield and safety of traditional plasma derivatives. Emerging cell-based technologies are being applied to discover novel protein activities and identify epitope-specific antibodies that may have clinical promise.
authors.affiliation: Plasma Derivatives Department, Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA. lathropj@usa.redcross.org
authors.forename: Julia Tait
authors.initials: JT
authors.lastname: Lathrop
authors.forename: N Leigh
authors.initials: NL
authors.lastname: Anderson
authors.forename: Norman G
authors.initials: NG
authors.lastname: Anderson
authors.forename: David J
authors.initials: DJ
authors.lastname: Hammond
mesh_terms: D000906:Antibodies / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D025202:Molecular Diagnostic Techniques; D020543:Proteome
chemical_list: D000906:Antibodies; D015415:Biomarkers; D001798:Blood Proteins; D020543:Proteome