title: Providencia alcalifaciens strains translocate from the gastrointestinal tract and are resistant to lytic activity of serum complement.
abstract: The ability of Providencia alcalifaciens strains, isolated from patients with diarrhoeal disease, to translocate from the gastrointestinal tract and their resistance to serum complement lytic activity were investigated and compared with previously characterized differential invasive capabilities in HeLa cells. Translocation ability to several extraintestinal sites and resistance to lysis by human serum complement were observed in both highly invasive and non-invasive strains. These characteristics have not been previously described in P. alcalifaciens and their potential role in causing disseminated infections should therefore be considered.
authors.affiliation: Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo -Escola Paulista de Medicina, São Paulo, SP, Brazil 04023-062 2Departamento de Patologia, Universidade Federal do Pará, PA, Brazil 3Disciplina de Técnica Operatória, Universidade Federal de São Paulo - Escola Paulista de Medicina, São Paulo, SP, Brazil 04023-062.
authors.forename: Antonia B R
authors.initials: ABR
authors.lastname: Vieira
authors.affiliation: Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo -Escola Paulista de Medicina, São Paulo, SP, Brazil 04023-062 2Departamento de Patologia, Universidade Federal do Pará, PA, Brazil 3Disciplina de Técnica Operatória, Universidade Federal de São Paulo - Escola Paulista de Medicina, São Paulo, SP, Brazil 04023-062.
authors.forename: Ivan H J
authors.initials: IHJ
authors.lastname: Koh
authors.affiliation: Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo -Escola Paulista de Medicina, São Paulo, SP, Brazil 04023-062 2Departamento de Patologia, Universidade Federal do Pará, PA, Brazil 3Disciplina de Técnica Operatória, Universidade Federal de São Paulo - Escola Paulista de Medicina, São Paulo, SP, Brazil 04023-062.
authors.forename: Beatriz E C
authors.initials: BEC
authors.lastname: Guth
mesh_terms: D003165:Complement System Proteins / Q000276:immunology*; D003967:Diarrhea / Q000382:microbiology; D004064:Digestive System / Q000382:microbiology*; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D006367:HeLa Cells; D006801:Humans; D011532:Providencia / Q000276:immunology* / Q000502:physiology*
chemical_list: D003165:Complement System Proteins