Effect of occlusive wound dressing supplemented with antiphlogistic and analgesic agents on plasma beta-endorphin in hot and humid environments: a study in pigs.
OBJECTIVE
To study the changes of plasma beta-endorphin (beta-EP) in pigs with traumatic injury after occlusive wound dressing supplemented with antiphlogistic and analgesic agents in hot and humid environments (HHE).


METHODS
Traumatic models were established in 10 pigs, 5 of which received antiphlogistic- and analgesic-supplemented occlusive dressings of the wounds (experiment group, EG), while the rest pigs were assigned to control group (CG) to receive routine wound management. The pigs in both groups were then exposed to artificial HHE and at different time points during the exposure, the plasma beta-EP level, respiratory frequency and heart rates were measured respectively.


RESULTS
The plasma beta-EP concentration of EG was significantly lower than that of CG (P <0.01) after the injury, but in both groups, the levels before the injury were similar to those measured at hour 8 during HHE exposure and at hour 24 following the injury. The variation range of the respiratory frequency and heart rates during HHE exposure were significantly smaller in EG than CG (P <0.01).


CONCLUSIONS
This supplemented occlusive wound dressing can help restrain the peak of plasma beta-EP level and the variation range of respiratory frequency and heart rates of pigs exposed to HHE.
Cai
Wen-zhi
WZ
Department of Nursing, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. caiwenzhi2002@hotmail.com
Li
Ya-jie
YJ
Cai
Bao-ta
BT
Zeng
Can-hui
CH
Wang
Ying
Y
Luo
Bing-de
BD
D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D005260:Female; D006339:Heart Rate; D006358:Hot Temperature; D006813:Humidity; D008297:Male; D009779:Occlusive Dressings; D012119:Respiration; D013552:Swine; D001615:beta-Endorphin / Q000097:blood*
D000700:Analgesics; D001615:beta-Endorphin