Autologous adult bone marrow stem cell transplantation in an animal model of huntington's disease: behavioral and morphological outcomes.
We investigated the effects of autologous bone marrow stem cell transplantation in a rat model of Huntington's Disease. Thirteen days after bilateral quinolinic lesions (QA), bone marrow was implanted into the damaged striatum. The ability of the transplants to reverse QA-induced cognitive deficits in the radial-arm water maze (RAWM) was examined. The transplants significantly reduced working memory deficits. Most of the transplanted cells appeared quite primitive. Because only a few cells expressed neural phenotypes, we suggest that the release of growth factors by the transplants allowed surviving cells within the caudate to function more efficiently and to facilitate other compensatory responses.
Lescaudron
Laurent
L
INSERM UMR 437, Institut de Transplantation et de Recherche en Transplantation, CHU Hôtel Dieu and Service de Physiologie Animale, Faculté des Sciences et des Techniques, Université de Nantes, France. Laurent.Lescaudron@nantes.inserm.fr
Unni
Divya
D
Dunbar
Gary L
GL
D000704:Analysis of Variance; D000818:Animals; D016026:Bone Marrow Transplantation; D002454:Cell Differentiation; D003342:Corpus Striatum / Q000473:pathology / Q000601:surgery*; D004195:Disease Models, Animal; D006816:Huntington Disease / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D009474:Neurons / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013028:Space Perception / Q000502:physiology; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology; D013550:Swimming / Q000502:physiology; D014182:Transplantation, Autologous / Q000473:pathology