Cord blood dendritic cells: subsets, functional characteristics and in vitro generation.
Dendritic cells (DCs) form a heterogeneous population of cells capable of stimulating naive T cells and initiating primary immune responses. This well-known function of DCs has offered the possibility of developing clinical protocols for their use in immunotherapy to tumours. DCs may also play a critical role in the induction of peripheral immunological tolerance, which could have important implications in the treatment of autoimmunity or in the outcome of clinical transplantation. Recent reports have indicated that cord blood transplantation is associated with a reduced incidence of graft versus host disease. Thus studies on the identification and characterisation of DCs present in, or derived from cord blood will help to understand their role, not only in neonatal immunity, but also in the outcome of cord blood transplantation.
Navarrete
Cristina V
CV
Department of Histocompatibility and Immunogenetics, National Blood Service, Colindale Avenue, London NW9 5BG, UK. cristina.navarrete@nbs.nhs.uk
Gómez
Jesús
J
Borràs
Francesc E
FE
D000818:Animals; D015703:Antigens, CD / Q000097:blood; D018952:Antigens, CD34 / Q000097:blood; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000145:classification* / Q000166:cytology*; D005312:Fetal Blood / Q000166:cytology*; D006801:Humans; D007231:Infant, Newborn
D015703:Antigens, CD; D018952:Antigens, CD34