Present and future of surface plasmon resonance biosensors.
Surface plasmon resonance (SPR) biosensors are optical sensors exploiting special electromagnetic waves-surface plasmon-polaritons-to probe interactions between an analyte in solution and a biomolecular recognition element immobilized on the SPR sensor surface. Major application areas include detection of biological analytes and analysis of biomolecular interactions where SPR biosensors provide benefits of label-free real-time analytical technology. This paper reviews fundamentals of SPR affinity biosensors and discusses recent advances in development and applications of SPR biosensors.
Homola
Jirí
J
Institute of Radio Engineering and Electronics, Academy of Sciences of the Czech Republic, Chaberská 57, Prague, Czech Republic. homola@ure.cas.cz
D015374:Biosensing Techniques; D004784:Environmental Monitoring / Q000295:instrumentation / Q000379:methods; D005504:Food Analysis / Q000295:instrumentation / Q000379:methods; D008962:Models, Theoretical; D020349:Surface Plasmon Resonance / Q000295:instrumentation / Q000379:methods