title: Biological role of p300 in cardiac myocytes.
abstract: A cellular target of adenovirus E1A oncoprotein, p300 is a transcriptional coactivator required for the maintenance of differentiated phenotypes in cardiac myocytes. The full transcriptional activities of hypertrophy-responsive transcription factors such as GATA-4 and MEF2 require interaction with p300. A p300 protein also possesses intrinsic histone acetyl transferase activity, which promotes a transcriptionally active chromatin configuration. Here, we review the biological functions of p300 in cardiac myocytes. Although p300 is biologically active in many cell types, this protein appears to play a crucial role in the differentiation, growth and apoptosis of cardiac myocytes. Understanding precise mechanisms of its biological functions will shed light on molecular pathways for heart failure.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto, Japan.
authors.forename: Tetsuhiko
authors.initials: T
authors.lastname: Yanazume
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Morimoto
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Wada
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Kawamura
authors.forename: Koji
authors.initials: K
authors.lastname: Hasegawa
mesh_terms: D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism*; D009687:Nuclear Proteins / Q000502:physiology*; D010641:Phenotype; D011485:Protein Binding; D015534:Trans-Activators / Q000502:physiology*; D014158:Transcription, Genetic
chemical_list: D009687:Nuclear Proteins; D015534:Trans-Activators