title: [Proliferating cell nuclear antigen expression in recurrent aphthous ulcer and its significance].
abstract: OBJECTIVE
  To explore the expression changes of proliferating cell nuclear antigen (PCNA) in oral normal mucosa and recurrent aphthous ulcers(RAU).
  
  
  METHODS
  The expression intensity and distribution of PCNA were examined with immunohistochemistry method in 15 cases of recurrent oral aphthous and normal oral mucosa.
  
  
  RESULTS
  In RAU, there was large amount of inflamed cells. In normal oral mucosa, the expression intensity of PCNA was significant higher than that in oral aphthous (P<0.05).
  
  
  CONCLUSIONS
  The inhibition of epidermal cells proliferation in RAU may be one of the mechanisms which one involved in RAU formation.
authors.affiliation: Department of Stomatology, 304th Hospital of People's Liberation Army, Beijing 100037, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.forename: Xiao-bing
authors.initials: XB
authors.lastname: Fu
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Jian-qiang
authors.initials: JQ
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Yan
mesh_terms: D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009061:Mouth Mucosa / Q000378:metabolism* / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000378:metabolism* / Q000473:pathology
chemical_list: D018809:Proliferating Cell Nuclear Antigen