title: Regional cerebral blood flow and EEG in clinically diagnosed dementia with Lewy bodies and Alzheimer's disease.
abstract: This study was undertaken in order to compare regional cerebral blood flow (rCBF) and EEG findings of patients with clinically diagnosed dementia with Lewy bodies (clinDLB) and Alzheimer's disease (clinAD). Furthermore, within the clinDLB group to compare cases with and without neuropathologically verified Lewy bodies (LBs). When we studied 200 dementia cases in a prospective longitudinal dementia study, 48 had clinDLB and 45 clinAD in retrospective analyses. EEG information was analysed in 34 clinDLB and 28 clinAD patients and cerebral blood flow, measured with the Xe 133 inhalation method, in 26 clinDLB and 25 clinAD. There were no differences in EEG between the clinDLB and clinAD groups or between the cases with and without LBs. The rCBF patterns in the clinDLB and clinAD groups showed similar reductions in the temporoparietal areas. The rCBF in cases with LBs showed heterogeneous pathology. The imaging results in clinDLB and clinAD were strikingly similar. The EEG and rCBF could not differentiate between cases with or without LB. The study illustrates the lack of specific changes of EEG and rCBF in cases with LB pathology.
authors.affiliation: Department of Psychogeriatrics, Lund University hospital, SE-221 85, Lund, Sweden. elisabet.londos@psykiatr.lu.se
authors.forename: Elisabet
authors.initials: E
authors.lastname: Londos
authors.forename: Ulla
authors.initials: U
authors.lastname: Passant
authors.forename: Arne
authors.initials: A
authors.lastname: Brun
authors.forename: Ingmar
authors.initials: I
authors.lastname: Rosén
authors.forename: Jarl
authors.initials: J
authors.lastname: Risberg
authors.forename: Lars
authors.initials: L
authors.lastname: Gustafson
mesh_terms: D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D016009:Chi-Square Distribution; D003627:Data Interpretation, Statistical; D004569:Electroencephalography; D005260:Female; D006801:Humans; D016631:Lewy Bodies; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012737:Sex Factors