title: Three-dose vs extended-course clindamycin prophylaxis for free-flap reconstruction of the head and neck.
abstract: BACKGROUND
  Twenty-four hours of perioperative antibiotics provides effective prophylaxis for most head and neck cancer resections. Many reconstructive surgeons have been hesitant to apply this standard to free-flap reconstruction of the head and neck. This prospective clinical trial compared short-course and long-course clindamycin prophylaxis for wound infection in patients with head and neck cancer undergoing free-flap reconstruction.
  
  
  METHODS
  Seventy-four patients were randomized to receive short-course (3 doses) or long-course (15 doses) clindamycin perioperatively. Wound infections, fistulas, and other postoperative complications were documented by faculty surgeons who were blinded as to treatment group.
  
  
  RESULTS
  The differences in wound infections and other complications were statistically insignificant. No other independent predictors of wound complications emerged in this series of patients.
  
  
  CONCLUSIONS
  Short-course clindamycin is as effective as long-course clindamycin in preventing wound infections after free-flap surgery for head and neck ablative defects.
authors.affiliation: Division of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, 35233, USA. William.Carroll@ccc.uab.edu
authors.forename: William R
authors.initials: WR
authors.lastname: Carroll
authors.forename: David
authors.initials: D
authors.lastname: Rosenstiel
authors.forename: Jobe R
authors.initials: JR
authors.lastname: Fix
authors.forename: Jorge
authors.initials: J
authors.lastname: de la Torre
authors.forename: Joel S
authors.initials: JS
authors.lastname: Solomon
authors.forename: Brian
authors.initials: B
authors.lastname: Brodish
authors.forename: Eben L
authors.initials: EL
authors.lastname: Rosenthal
authors.forename: Tad
authors.initials: T
authors.lastname: Heinz
authors.forename: Santosh
authors.initials: S
authors.lastname: Niwas
authors.forename: Glenn E
authors.initials: GE
authors.lastname: Peters
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013524:Surgical Flaps; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin