title: Proton pump inhibitors as a risk factor for Clostridium difficile diarrhoea.
abstract: Clostridium difficile is the main infectious cause of colitis in hospital inpatients. The incidence is increasing, and it is associated with significant mortality, morbidity, and increased length of stay. The main risk factor is use of broad-spectrum antibiotics, and antibiotic restriction is the most effective control measure. We carried out a retrospective case-control study to investigate whether use of proton pump inhibitors (PPI) was an additional risk factor. PPI use within the preceding eight weeks was associated with an increased risk of C. difficile diarrhoea (odds ratio 2.5, 95% CI 1.5-4.2). Reduction of unnecessary PPI use may be an additional strategy to reduce the incidence of this infection.
authors.affiliation: Plymouth Public Health Laboratory, Derriford Hospital, Plymouth, UK. richard.cunningham@phnt.swest.nhs.uk
authors.forename: R
authors.initials: R
authors.lastname: Cunningham
authors.forename: B
authors.initials: B
authors.lastname: Dale
authors.forename: B
authors.initials: B
authors.lastname: Undy
authors.forename: N
authors.initials: N
authors.lastname: Gaunt
mesh_terms: D000126:Achlorhydria / Q000209:etiology; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000209:etiology*; D003967:Diarrhea / Q000382:microbiology*; D004791:Enzyme Inhibitors / Q000009:adverse effects*; D006760:Hospitalization; D006801:Humans; D017494:Proton Pumps / Q000378:metabolism*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D004791:Enzyme Inhibitors; D017494:Proton Pumps