title: Cell adhesion molecules: key players in memory consolidation?
abstract: Experimental evidence implies that L1 and neural cell adhesion molecule (NCAM) are involved in long-term memory formation. Changes in their expression and glycosylation appear to modify the synaptic strength underlying memory consolidation. Interference with L1 and NCAM function in a variety of learning tasks in different species severely attenuates memory consolidation, indicating their involvement in an evolutionary conserved mechanism of neural plasticity.
authors.affiliation: Division of Neuroanatomy and Behavior, Institute of Anatomy, University of Zurich, CH-8057 Zurich, Switzerland.
authors.forename: Hans
authors.initials: H
authors.lastname: Welzl
authors.forename: Oliver
authors.initials: O
authors.lastname: Stork
mesh_terms: D000818:Animals; D008568:Memory / Q000502:physiology*; D039842:Neural Cell Adhesion Molecule L1 / Q000502:physiology*; D019006:Neural Cell Adhesion Molecules / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*
chemical_list: D039842:Neural Cell Adhesion Molecule L1; D019006:Neural Cell Adhesion Molecules