Comparison of various simple insulin sensitivity and beta-cell function indices in lean hyperandrogenemic and normoandrogenemic young hirsute women.
OBJECTIVE
To assess and compare various simple insulin sensitivity and beta-cell function indices in lean, hirsute, young women.


METHODS
Prospective study.


METHODS
Departments of endocrinology and metabolism at a university and a state hospital.


METHODS
Seventy-one hirsute young women were classified as hyperandrogenemic or normoandrogenemic.


METHODS
Insulin sensitivity and beta-cell function indices derived from a single sample and an oral glucose tolerance test (OGTT).


RESULTS
Lean hyperandrogenemic hirsute women have insulin resistance and increased beta-cell function. The most sensitive indices of insulin resistance were total and 1-hour and 2-hour post-challenge insulin levels during OGTT. When a cut-off value of 3.2 or greater for homeostasis model assessment of insulin resistance (HOMA-IR) was accepted, 46% of hyperandrogenemic women and 30% of normoandrogenemic women were insulin resistant. Fasting insulin level was best correlated with the fasting insulin resistance index, HOMA-IR, and Quicky index. The HOMA-IR was best correlated with fasting insulin level and the hepatic insulin sensitivity index (ISI(HOMA)).


CONCLUSIONS
Insulin levels based on OGTT are the most useful index of insulin resistance and beta-cell function index in hirsute women. The HOMA-IR may be a proposed global test for insulin resistance; it correlated well with both OGTT-derived insulin resistance and beta-cell function indices and with global insulin resistance indices derived from a single sample (such as ISI (HOMA), Quicky index, FIRI(-1), fasting Belfiore index, and glucose/insulin ratio).
Altuntas
Yuksel
Y
Department of Endocrinology and Metabolism, Internal Medicine Clinic, Sisli Etfal Education and Research Hospital, Istanbul, Turkey. yukselaltuntas@yahoo.com
Bilir
Muammer
M
Ozturk
Bulent
B
Gundogdu
Sadi
S
D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005951:Glucose Tolerance Test; D006628:Hirsutism / Q000378:metabolism*; D006801:Humans; D017588:Hyperandrogenism / Q000378:metabolism* / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D007515:Islets of Langerhans / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D013739:Testosterone / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone