Secondary hypertension due to a renin-producing teratoma.
Twenty cases of extrarenal renin-secreting tumors have been reported, but this is the first case of a renin-producing teratoma. The patient was a 17-year-old African American girl who presented with hypertension and hypokalemia, and who was documented to have a plasma aldosterone-to-renin activity ratio consistent with secondary aldosteronism. Computed tomography demonstrated a pelvic tumor suspicious for a teratoma. With no other apparent etiology for the secondary aldosteronism, the teratoma was suspected to be an extrarenal renin-secreting tumor. This was confirmed after surgery by pathologic evaluation, and significantly reduced requirements for antihypertensive medication and potassium supplementation.
Pursell
Robert N
RN
Department of Medicine, Hahnemann Hospital, Philadelphia, Pennsylvania, USA.
Quinlan
Pamela M
PM
D000293:Adolescent; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D010386:Pelvic Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000601:surgery; D012083:Renin / Q000378:metabolism; D013724:Teratoma / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000601:surgery; D014057:Tomography, X-Ray Computed
D012083:Renin