Robust regression-based analysis of drug-nucleic acid binding.
Outlier detection can be very important in analyzing data from Scatchard plots. In this study, a robust (outlier-resistant) regression procedure was used in conjunction with a Scatchard plot to study the binding of the methylphenazinium cation with double-stranded DNA. The procedures, their results, and their advantages are discussed.
Booth
David E
DE
Graduate School of Management, Kent State University, Kent, OH 44242, USA. dbooth@kent.edu
Lee
Kidong
K
D004247:DNA / Q000378:metabolism*; D008773:Methylphenazonium Methosulfate / Q000378:metabolism*; D015233:Models, Statistical; D012044:Regression Analysis
D008773:Methylphenazonium Methosulfate; D004247:DNA