Extensive transmission of Mycobacterium tuberculosis among congregated, HIV-infected prison inmates in South Carolina, United States.
BACKGROUND
In August 1999, a prison inmate infected with the human immunodeficiency virus (HIV) was diagnosed with pulmonary tuberculosis (TB). This source patient lived in a prison dormitory housing over 300 HIV-infected men, and was symptomatic for at least 2 months prior to diagnosis. We report a large outbreak of TB in HIV-infected prison inmates with subsequent transmission of Mycobacterium tuberculosis outside the prison.


METHODS
Exposed inmates were screened by symptom review, chest radiograph and tuberculin skin test (TST) in September and December 1999. We recorded CD4 cell counts, viral loads and receipt of highly active antiretroviral therapy (HAART).


RESULTS
The source patient lived on the right side of a two-sided dormitory exclusively housing HIV-infected men. Of 114 men tested from the right side, 75 (66%) had documented TST conversions. Of 96 converters overall, 82 (85%) had TSTs measuring > or = 15 mm. Within 6 months of diagnosis of TB in the source patient, 30 additional inmates and a healthcare worker who cared for the source patient developed TB disease. Two other inmates developed TB disease in spring of 2001.


CONCLUSIONS
We describe extensive transmission of M. tuberculosis in a group of HIV-infected prison inmates with high TST conversion rates and subsequent transmission in the community. In settings where HIV-infected persons are congregated, the consequences of TB outbreaks are magnified.
McLaughlin
S I
SI
National Immunization Program, Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. SWM4@cdc.gov
Spradling
P
P
Drociuk
D
D
Ridzon
R
R
Pozsik
C J
CJ
Onorato
I
I
D000328:Adult; D016358:Contact Tracing; D004196:Disease Outbreaks; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D011329:Prisoners; D013022:South Carolina / Q000453:epidemiology; D014376:Tuberculosis / Q000635:transmission*