Oligonucleotides with strongly fluorescent groups pi-conjugated to a nucleobase: syntheses, melting temperatures, and conformation.
Phosphoramidite 1 was prepared, incorporated into oligonucleotides, and these were studied via thermal denaturation and circular dichroism.
Jiao
Guan-Sheng
GS
Department of Chemistry, PO Box 30012, Texas A & M University, College Station, TX 77842-3012, USA.
Burgess
Kevin
K
D000215:Acylation; D002942:Circular Dichroism; D005456:Fluorescent Dyes / Q000737:chemistry; D007536:Isomerism; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D044366:Transition Temperature
D005456:Fluorescent Dyes; D009841:Oligonucleotides; D009943:Organophosphorus Compounds; C434331:phosphoramidite