Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling.
The low density lipoprotein receptor-related protein (LRP) is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes. Deletion of the LRP gene in mice is lethal, confirming an important role for this receptor in development, although its exact function in development is still not known. In addition to its role in the endocytosis of numerous ligands, recent studies are emerging that describe a signaling role for this receptor as well.
Strickland
D K
DK
Department of Vascular Biology, Jerome H. Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, MD, USA. strickla@usa.redcross.org
Ranganathan
S
S
D000818:Animals; D001777:Blood Coagulation; D003593:Cytoplasm / Q000378:metabolism; D004705:Endocytosis; D010450:Endopeptidases / Q000378:metabolism*; D017353:Gene Deletion; D006801:Humans; D008024:Ligands; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008247:Lysosomes / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D015843:Serpins / Q000378:metabolism; D015398:Signal Transduction; D014443:Tyrosine / Q000378:metabolism
D008024:Ligands; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D015843:Serpins; D014443:Tyrosine; D010450:Endopeptidases