title: Identification of harman as the antibiotic compound produced by a tunicate-associated bacterium.
abstract: The alkaloid harman, previously reported from some marine invertebrates, was identified as the antibiotic substance of the tunicate-associated bacterium Enterococcus faecium. It exhibited antibacterial activity (MIC, 0.017 mM) against the ichthyopathogenic strain Vibrio anguillarum.
authors.affiliation: Laboratoire de Biochimie Marine, Département de Biologie, Faculté des Sciences, Université Chouaib Doukkali, BP 20 El Jadida, Morocco.
authors.forename: H
authors.initials: H
authors.lastname: Aassila
authors.forename: M L
authors.initials: ML
authors.lastname: Bourguet-Kondracki
authors.forename: S
authors.initials: S
authors.lastname: Rifai
authors.forename: A
authors.initials: A
authors.lastname: Fassouane
authors.forename: M
authors.initials: M
authors.lastname: Guyot
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D016984:Enterococcus faecium / Q000302:isolation & purification / Q000378:metabolism*; D006247:Harmine / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D014561:Urochordata / Q000382:microbiology*; D014733:Vibrio / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D006247:Harmine; C005010:harman