title: Argon plasma coagulation for radiation proctitis.
abstract: Radiation proctitis is a well-recognized complication following radiotherapy for pelvic malignancy. This study was designed to compare the efficacy and complications of argon plasma coagulation (APC) using the power setting of 50 W vs. 60 W in a group of patients with radiation proctitis. Forty-two patients were randomized to undergo APC using the electrical power setting of 60 W (23 patients, group A) or 50 W (19 patients, group B). Patients were asked to estimate the severity of major symptoms before and after APC using a scoring system graded 0-4. The score of major symptoms before and after APC, mean duration of the procedure, number of sessions, side effects/complications were noted. Statistical analysis was performed using Fisher's Exact Test and the 2-tailed p value less than 0.05 was considered statistically significant. A significant improvement of major symptoms was noted in all patients treated with APC, irrespective of the wattage we used, apart from the presence and severity of tenesmus. The mean number of treatment sessions to achieve control of bleeding was 1.34 for group A and 1.9 for group B and the mean time of treatment sessions was significantly shorter for group A (15 min vs. 17 min for group B). No significant differences in early side effects and long term complications between the two groups were evidenced. We can conclude that there is no statistical significance concerning efficacy and side effects of APC application between the 60W and 50W power setting, but the number of sessions and duration of the procedure tend to differ significantly. Rectal stenoses have been described only in patients treated with higher power settings.
authors.affiliation: Center of Gastroenterology and Hepatology, Fundeni Clinical Institute, Bucharest, Romania. drgheorghe@xnet.ro.
authors.forename: Cristian
authors.initials: C
authors.lastname: Gheorghe
authors.forename: Liana
authors.initials: L
authors.lastname: Gheorghe
authors.forename: Răzvan
authors.initials: R
authors.lastname: Iacob
authors.forename: Sperana
authors.initials: S
authors.lastname: Iacob
authors.forename: Iulia
authors.initials: I
authors.lastname: Simionov
authors.forename: Iont
authors.initials: I
authors.lastname: Băncilă
mesh_terms: D000368:Aged; D001128:Argon / Q000627:therapeutic use; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000628:therapy*; D006801:Humans; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D011349:Proctitis / Q000209:etiology / Q000628:therapy*; D011446:Prospective Studies; D011832:Radiation Injuries / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D001128:Argon