The stress experience dependent long-term depression disassociated with stress effect on spatial memory task.
Behavioral stress can either block or facilitate memory and affect the induction of long-term potentiation (LTP) and long-term depression (LTD). However, the relevance of the stress experience-dependent long-term depression (SLTD) to spatial memory task is unknown. Here we have investigated the effects of acute and sub-acute elevated platform (EP) and foot shock (FS) stress on LTD induction in CA1 region of the hippocampus of anesthetized rats and spatial memory in Morris water maze. We found that LTD was facilitated by acute EP stress, but not by sub-acute EP stress that may be due to the fast adaptation of the animals to this naturalistic mild stress. However, FS stress, an inadaptable strong stress, facilitated LTD induction both in acute and sub-acute treatment. In addition, with the same stress protocols, acute EP stress impaired spatial memory but the sub-acute EP stressed animals performed the spatial memory task as well as the controls, may due to the same reason of adaptation. However, acute FS stress slightly impaired learning but sub-acute FS even enhanced memory retrieval. Our results showed that SLTD was disassociated with the effect of stress on memory task but might be related to stress experience-dependent form of aberrant memory.
Xiong
Wenyong
W
Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, Yunnan, China.
Yang
Yuexiong
Y
Cao
Jun
J
Wei
Huiming
H
Liang
Chongli
C
Yang
Shangchuan
S
Xu
Lin
L
D000220:Adaptation, Biological; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D004558:Electric Stimulation; D004597:Electroshock / Q000379:methods; D004924:Escape Reaction / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D006624:Hippocampus / Q000503:physiopathology; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051381:Rats; D011930:Reaction Time; D013028:Space Perception / Q000502:physiology*; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors