Metal-enhanced emission from indocyanine green: a new approach to in vivo imaging.
Indocyanine green (ICG) is widely used in medical imaging and testing. Its complex spectral behavior and low quantum yield limits some applications. We show that proximity of ICG to a metallic silver particle increases its intensity approximately 20-fold and decreases the decay time. Since the rate of photobleaching is not increased, our results suggest that ICG-silver particle complexes can yield at least 20-fold more photons per ICG molecule for improved medical imaging.
Malicka
Joanna
J
University of Maryland School of Medicine, Department of Biochemistry & Molecular Biology, Center for Fluorescence Spectroscopy, 725 W. Lombard Street, Baltimore, Maryland 21201-1503, USA.
Gryczynski
Ignacy
I
Geddes
Chris D
CD
Lakowicz
Joseph R
JR
D003198:Computer Simulation; D005453:Fluorescence; D006801:Humans; D007208:Indocyanine Green / Q000737:chemistry*; D046911:Macromolecular Substances; D008670:Metals / Q000737:chemistry; D008956:Models, Chemical; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*
D046911:Macromolecular Substances; D008670:Metals; D012709:Serum Albumin; D012834:Silver; D007208:Indocyanine Green