Major histocompatibility complex-dependent susceptibility to Cryptococcus neoformans in mice.
To evaluate the role of major histocompatibility complex (MHC) genes in the resistance to Cryptococcus neoformans, we conducted infection experiments in MHC-congenic strains of mice. Significant MHC-dependent susceptibility differences were found among homozygotes and heterozygotes. This study is the first experimental demonstration of MHC-dependent susceptibility to C. neoformans infections in mice and indicates that MHC genes can be important in host resistance.
McClelland
Erin E
EE
Biology Department, University of Utah, Salt Lake City, Utah 84112, USA. Erin.McClelland@m.cc.utah.edu
Granger
Donald L
DL
Potts
Wayne K
WK
D000818:Animals; D015169:Colony Count, Microbial; D003453:Cryptococcosis / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D005260:Female; D005838:Genotype; D006183:H-2 Antigens / Q000235:genetics; D006239:Haplotypes; D006579:Heterozygote; D006720:Homozygote; D008099:Liver / Q000382:microbiology; D008285:Major Histocompatibility Complex; D051379:Mice; D020297:Mice, Congenic; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013045:Species Specificity
D006183:H-2 Antigens