7-keto-delta(5)-steroids: key-molecules owning particular biological and chemical interest.
7-keto-Delta(5)-steroids have been suggested for the treatment of several diseases. Their significant biological profile resulted in the development of a great number of methods and reagents for the allylic oxidation of Delta(5)-steroids. These methods and the biological evaluation of the main oxidized Delta(5)-steroids are summarized.
Arsenou
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ES
Department of Pharmacy, School of Health Sciences, University of Patras, 265 00 Rion-Patra, Greece.
Fousteris
M A
MA
Koutsourea
A I
AI
Nikolaropoulos
S S
SS
D002784:Cholesterol / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D002857:Chromium / Q000737:chemistry; D003687:Dehydroepiandrosterone / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007664:Ketosteroids / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D020122:tert-Butylhydroperoxide / Q000737:chemistry
D007664:Ketosteroids; D002857:Chromium; D003687:Dehydroepiandrosterone; D020122:tert-Butylhydroperoxide; D002784:Cholesterol; D010100:Oxygen