title: Prenatal cocaine/polydrug exposure and infant performance on an executive functioning task.
abstract: Executive functioning in cocaine/polydrug (marijuana, alcohol, tobacco) exposed infants was assessed in a single session, occurring between 9.5 and 12.5 months of age. In an A-not-B task, infants searched, after performance-adjusted delays, for an object hidden in a new location. Overall, the cocaine-exposed (CE) infants did not differ from non-CE controls recruited from the same at-risk population. However, comparison of heavier-CE (n = 9) to the combined group of lighter-CE (n = 10) and non-CE (n = 32) infants revealed significant differences on A-not-B performance, as well as on global tests of mental and motor development. Covariates investigated included socioeconomic status, marital status, race, maternal age, years of education, weeks of gestation, birth weight, as well as severity of prenatal marijuana, alcohol, and tobacco exposure. The relationship of heavier-CE status to motor development was mediated by length of gestation, and the relationship of heavier-CE status to mental development was confounded with maternal gestational use of cigarettes. The relationship of heavier-CE status to A-not-B performance remained significant after controlling for potentially confounded variables and mediators, but was not statistically significant after controlling for the variance associated with global mental development.
authors.affiliation: Department of Pediatrics and General Medical Sciences, Case Western Reserve University, USA. jsn4@po.cwru.edu
authors.forename: Julia S
authors.initials: JS
authors.lastname: Noland
authors.forename: Lynn T
authors.initials: LT
authors.lastname: Singer
authors.forename: Sudhir K
authors.initials: SK
authors.lastname: Mehta
authors.forename: Dennis M
authors.initials: DM
authors.lastname: Super
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D002188:Cannabis / Q000009:adverse effects; D002657:Child Development; D003042:Cocaine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009420:Nervous System / Q000187:drug effects* / Q000254:growth & development / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications; D011297:Prenatal Exposure Delayed Effects; D011597:Psychomotor Performance / Q000187:drug effects*; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D003042:Cocaine