Regulation of adhesion and motility in B lymphocytes.
During the differentiation process of B lymphocytes, they go through changes in adhesion and motility. In order to investigate the molecular mechanism of such changes, in vitro culture systems are necessary. When B cells are activated by various stimuli, they form different types of homotypic aggregates. In addition, they might also spread and express microvilli and/or become polarized, the latter being a sign of motility. In this review, we summarize our own research in this area. We give evidence for involvement of different adhesion and signalling molecules, and by the end, we speculate on the in vivo significance of our findings.
Severinson
E
E
Department of Cell and Molecular Biology, Karolinska Institutet, Box 285, SE-171 77 Stockholm, Sweden. eva.severinson@cmb.ki.se
Westerberg
L
L
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002448:Cell Adhesion / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D002465:Cell Movement / Q000276:immunology*; D016764:Cell Polarity / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008871:Microvilli / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology
D015815:Cell Adhesion Molecules