title: Successful treatment of extramammary Paget's disease with imiquimod.
abstract: Extramammary Paget's Disease (EMPD) is an uncommon neoplasm found in the genital, anorectal, or axillary area. Surgical excision is considered the standard treatment, although possible loss of tissue function and disease recurrence are seen. Other treatment modalities such as radiotherapy, topical chemotherapy, and photodynamic therapy are associated with varying degrees of effectiveness, but the search for an effective, safe treatment with minimal side effects proves to be challenging. We report a case where complete clinical and histological resolution of non-invasive EMPD of the penis was achieved with minimal adverse effects after six weeks of imiquimod (Aldara) application. As an immune system modifier that stimulates cytokine and interferon production, imiquimod may be a useful alternative or adjuvant in the treatment of EMPD.
authors.affiliation: Department of Dermatology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Qian
authors.forename: Nathalie C
authors.initials: NC
authors.lastname: Zeitoun
authors.forename: Sherry
authors.initials: S
authors.lastname: Shieh
authors.forename: Thomas
authors.initials: T
authors.lastname: Helm
authors.forename: Allan R
authors.initials: AR
authors.lastname: Oseroff
mesh_terms: D000368:Aged; D000634:Aminoquinolines / Q000627:therapeutic use*; D006801:Humans; D000077271:Imiquimod; D008297:Male; D010145:Paget Disease, Extramammary / Q000188:drug therapy* / Q000473:pathology; D010412:Penile Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000634:Aminoquinolines; D000077271:Imiquimod