title: [Study of sexual hormone changes in prostate cancer patients before and after androgen deprivation therapy].
abstract: OBJECTIVE
  To investigate and observe serum sexual hormone (testosterone, T; free testosterone, FT; dihydrotestosterone, DHT) changes in patients with prostate cancer (PCa) before and after androgen deprivation.
  
  
  METHODS
  Serum T, FT, DHT were measured with radioimmunoassay in 16 cases with PCa respectively one week before and the fifth day after androgen deprivation. The changes of T, FT, DHT were analyzed.
  
  
  RESULTS
  Serum T, FT, DHT declined 92.27%, 92.26%, 58.36% respectively. They were statistically significant before and after androgen deprivation (P < 0.001).
  
  
  CONCLUSIONS
  After androgen deprivation, most T and FT were deprived while DHT declined 58.36% only. Androgen receptor competitor shall be applied continually to prohibit the action of remnant androgen.
authors.affiliation: Department of Urology, Shanghai Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ying
authors.forename: De-Hong
authors.initials: DH
authors.lastname: Yao
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Ren
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use*; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000628:therapy*
chemical_list: D000726:Androgen Antagonists; D012739:Gonadal Steroid Hormones