title: Association between interleukin-8 gene alleles and human susceptibility to tuberculosis disease.
abstract: Interleukin (IL)-8 is involved in the pathogenesis of human tuberculosis (TB). However, the contribution of polymorphisms of the IL-8 gene and its receptor genes CXCR-1 and CXCR-2 to human TB susceptibility remains untested. In a case-control study, white subjects with TB disease were more likely to be homozygous for the IL-8 -251A allele, compared with control subjects (odds ratio [OR], 3.41; 95% confidence interval [CI], 1.52-7.64). African Americans with TB also showed an increased odds of being homozygous for this allele (OR, 3.46; 95% CI, 1.48-8.08). To exclude population artifacts in the case-control study, a separate analysis that used a transmission-disequilibrium test with 76 informative families confirmed that the IL-8 -251A allele was preferentially transmitted to TB-infected children (P=.02). CXCR-1 and CXCR-2 did not demonstrate significant associations with TB susceptibility. These data suggest that IL-8 is important in the genetic control of human TB susceptibility.
authors.affiliation: Department of Pathology, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
authors.forename: Robert A
authors.initials: RA
authors.lastname: Reich
authors.forename: John A
authors.initials: JA
authors.lastname: Wright
authors.forename: Heather R
authors.initials: HR
authors.lastname: Tooker
authors.forename: Larry D
authors.initials: LD
authors.lastname: Teeter
authors.forename: James M
authors.initials: JM
authors.lastname: Musser
authors.forename: Edward A
authors.initials: EA
authors.lastname: Graviss
mesh_terms: D000293:Adolescent; D000483:Alleles; D044383:Black People; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D016209:Interleukin-8 / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D009679:Nuclear Family; D013781:Texas / Q000453:epidemiology; D014376:Tuberculosis / Q000453:epidemiology / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics; D044465:White People; D001741:Black or African American
chemical_list: D016209:Interleukin-8