[Impulse activity of neurons in the lateral hypothalamus during microionophoretic administration of melatonin and noradrenaline in rats].
Microionophoretic administration of melatonin into the perineuronal space of lateral hypothalamic neurons in WAG and Fischer-344 rats decreased the firing rate and regularized activity of the cells. Moreover, the effects of melatonin completely blocked the activation of neurons and changes in their pulse activity produced by norepinephrine. The effects of melatonin on neuronal activity in behaviorally active stress-resistant WAG rats were more pronounced than in behaviorally passive stress-predisposed Fischer-344 rats. These data suggest that stress-protective activity of melatonin is associated with inhibition of the pulse activity of neurons in emotiogenic structures of the brain and changes in neuronal sensitivity to norepinephrine.
Pertsov
S S
SS
P.K. Anokhin Research Institute of Normal Physiology, Russian Acad. Med. Sci., Moscow 103009, B. Nikitskaya, 6, Russia.
Meshcheriakov
A F
AF
Glushkov
R G
RG
Sudakov
K V
KV
D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D020022:Genetic Predisposition to Disease; D007026:Hypothalamic Area, Lateral / Q000187:drug effects / Q000502:physiology*; D007478:Iontophoresis; D008297:Male; D008550:Melatonin / Q000008:administration & dosage / Q000494:pharmacology*; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D013315:Stress, Psychological / Q000235:genetics / Q000503:physiopathology
D008550:Melatonin; D009638:Norepinephrine