title: Antimicrobial susceptibility and macrolide resistance inducibility of Streptococcus pneumoniae carrying erm(A), erm(B), or mef(A).
abstract: Erythromycin-resistant Streptococcus pneumoniae isolates from young carriers were tested for their antimicrobial susceptibility; additionally, inducibility of macrolide and clindamycin resistance was investigated in pneumococci carrying erm(A), erm(B), or mef(A). Of 125 strains tested, 101 (81%) were multidrug resistant. Different levels of induction were observed with erythromycin, miocamycin, and clindamycin in erm(B) strains; however, in erm(A) strains only erythromycin was an inducer. Induction did not affect macrolide MICs in mef(A) strains.
authors.affiliation: Department of Pediatrics, General University Hospital, University of Patras, School of Medicine, Patras, Greece. syrogian@med.upatras.gr
authors.forename: George A
authors.initials: GA
authors.lastname: Syrogiannopoulos
authors.forename: Ioanna N
authors.initials: IN
authors.lastname: Grivea
authors.forename: Lois M
authors.initials: LM
authors.lastname: Ednie
authors.forename: Bülent
authors.initials: B
authors.lastname: Bozdogan
authors.forename: George D
authors.initials: GD
authors.lastname: Katopodis
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Beratis
authors.forename: Todd A
authors.initials: TA
authors.lastname: Davies
authors.forename: Peter C
authors.initials: PC
authors.lastname: Appelbaum
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D004917:Erythromycin / Q000494:pharmacology; D005798:Genes, Bacterial / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008780:Methyltransferases / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D011008:Pneumococcal Infections / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C117866:MefA protein, Streptococcus; D008565:Membrane Proteins; D004917:Erythromycin; D008780:Methyltransferases; C431709:ErmA protein, Bacteria; C035181:rRNA (adenosine-O-2'-)methyltransferase