[Study on relationship between tongue picture and cell apoptosis in patients with chronic gastritis].
OBJECTIVE
To study the characteristics of cell apoptosis in patients of chronic gastritis with different tongue pictures and its mechanism of formation.


METHODS
The tongue picture, apoptosis index (AI) of lingual epithelial cells, apoptosis related gene proteins, such as p53, Bcl-2 and Fas in 109 patients of chronic superficial gastritis were observed.


RESULTS
AI was different in patients with different tongue proper and tongue coating, those with pale white tongue and white thick coating had the maximum value of AI. (2) The p53, Bcl-2 and Fas expression positive rates in patients with different tongue pictures had corresponding changes, which were related not only with color of tongue, but also with color and thickness of tongue coating.


CONCLUSIONS
The formation of tongue picture is closely related with cell apoptosis, p53, Bcl-2 and Fas take part in the regulation of cell apoptosis, which constitute together the cytologic basis of tongue picture in the disease.
Li
Can-dong
CD
Fujian University of TCM, Fuzhou 350003. lcd688@sina.com
Lan
Qi-fang
QF
Zhang
Jian-juan
JJ
D000293:Adolescent; D000328:Adult; D017209:Apoptosis; D002908:Chronic Disease; D005260:Female; D005756:Gastritis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis / Q000235:genetics; D014059:Tongue / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000235:genetics; D019014:fas Receptor / Q000096:biosynthesis / Q000235:genetics
D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D019014:fas Receptor