Sinus grafting with autogenous platelet-rich plasma and bovine hydroxyapatite. A histomorphometric study in minipigs.
In this study, bovine hydroxyapatite (HA) alone or in combination with activated platelet-rich plasma (PRP) was examined for its usefulness for single-stage sinus grafting in minipigs. In 12 adult minipigs, Schneider's membrane of 24 sinuses was elevated bilaterally through an extra-oral approach. The material was divided into two groups of 12 sinuses. In one of these groups, the space between Schneider's membrane and the sinus wall was grafted with activated autogenous PRP and HA (PRP side). In the other, HA alone was used for grafting (control side). At the same time two dental implants with a machined surface were inserted into the grafting material through the facial sinus wall. Four animals of each group were sacrificed at 3, 6 and 12 weeks, and undecalcified thin-cut and ground sections (Donath 1988) stained with toluidine blue were prepared. In the facial sinus wall, fewer bone-to-implant contacts were present on the PRP side at 3 and 6 weeks than on the control side. At 12 weeks, the PRP side had caught up with the control side. In grafted bone, contacts on the PRP side were more extensive than on the control side at 3 weeks, had dropped below control side levels at 6 weeks and surpassed these at 12 weeks. This study showed that PRP has a differential effect on osseointegration in grafted bone and local host bone. Combined with HA it was not demonstrably superior to HA alone.
Fürst
Gabor
G
Department of Oral Surgery, University of Vienna School of Dentistry, Vienna, Austria. gabor.fuerst@univie.ac.at
Gruber
Reinhard
R
Tangl
Stefan
S
Zechner
Werner
W
Haas
Robert
R
Mailath
Georg
G
Sanroman
Fidel
F
Watzek
Georg
G
D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001857:Bone Matrix / Q000637:transplantation; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D015921:Dental Implants; D017886:Durapatite / Q000627:therapeutic use*; D005260:Female; D008297:Male; D008437:Maxilla / Q000473:pathology / Q000601:surgery*; D008443:Maxillary Sinus / Q000473:pathology / Q000601:surgery*; D008903:Minerals / Q000627:therapeutic use; D009092:Mucous Membrane / Q000601:surgery; D016348:Osseointegration; D017713:Platelet Transfusion; D013499:Surface Properties; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome
C077540:Bio-Oss; D018786:Bone Substitutes; D015921:Dental Implants; D008903:Minerals; D017886:Durapatite