title: Cytogenetic study of malignant triton tumor: a case report.
abstract: Malignant triton tumor (MTT) is a highly malignant neoplasm, classified as a variant of malignant peripheral nerve sheath tumor (MPNST) with rhabdomyoblastic differentiation. Few cytogenetic studies of MTT have been reported using conventional cytogenetic analysis. Here, we report a comprehensive cytogenetic study of a case of MTT using G-banding, Spectral Karyotyping(), and fluorescence in situ hybridization (FISH) for specific regions. A complex hyperdiploid karyotype with multiple unbalanced translocations was observed: 48 approximately 55,XY,der(7)add(7)(p?)dup(7)[2],der(7) t(7;20)(p22;?)ins(20;19)[5],der(7)ins(8;7)(?;p22q36)t(3;8)t(8;20)[15],-8[5],-8[19],r(8)dup(8), +der(8)r(8;22)[4],-9[9],der(11)t(11;20)(p15;?)ins(20;19)[22],der(12)t(8;12)(q21;p13)[21],der(13) t(3;13)(q25;p11),-17,-19,der(19)t(17;19)(q11.2;q13.1),-20,-22,+4 approximately 7r[cp24]/46,XY[13]. The 1995 International System for Human Cytogenetic Nomenclature was followed where possible. Note that breakpoints were frequently omitted where only SKY information was known for a small part of an involved chromosome. Our analysis revealed some breakpoints in common with those previously reported in MTT, MPNST, and rhabdomyosarcoma, namely 7p22, 7q36, 11p15, 12p13, 13p11.2, 17q11.2, and 19q13.1. FISH showed high increase of copy number for MYC and loss of a single copy for TP53.
authors.affiliation: Departments of Pathology and Oncology, The Johns Hopkins University School of Medicine, 600 N. Wolfe Street Carnegie 367, Baltimore MD 21287, USA.
authors.forename: Mary H
authors.initials: MH
authors.lastname: Haddadin
authors.forename: Anita L
authors.initials: AL
authors.lastname: Hawkins
authors.forename: Patricia
authors.initials: P
authors.lastname: Long
authors.forename: Laura A
authors.initials: LA
authors.lastname: Morsberger
authors.forename: Dawn
authors.initials: D
authors.lastname: Depew
authors.forename: Jonathan I
authors.initials: JI
authors.lastname: Epstein
authors.forename: Constance A
authors.initials: CA
authors.lastname: Griffin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D016158:Genes, p53; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D018317:Nerve Sheath Neoplasms / Q000235:genetics*