title: Takanawaenes, novel antifungal antibiotics produced by Streptomyces sp. K99-5278. I. Taxonomy, fermentation, isolation and biological properties.
abstract: Three new pentaene macrolides having a 28-membered ring, designated takanawaenes A, B and C, were isolated from the fermentation broth of Streptomyces sp. K99-5278 by solvent extraction, silica-gel column chromatography and HPLC. Takanawaenes showed antifungal activity against Aspergillus niger, Mucor racemosus, Candida albicans and Saccharomyces cerevisiae.
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University and The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
authors.forename: Yong-Pil
authors.initials: YP
authors.lastname: Kim
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Kousuke
authors.initials: K
authors.lastname: Iizima
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukuda
authors.forename: Atsuko
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Yoko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D011090:Polyenes / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D007783:Lactones; D011090:Polyenes; C476106:takanawaene A; C476108:takanawaene B; C476109:takanawaene C