title: Intracellular expression of the Salmonella plasmid virulence protein, SpvB, causes apoptotic cell death in eukaryotic cells.
abstract: The spv genes carried on the Salmonella virulence plasmid are commonly associated with severe systemic infection in experimental animals. The SpvB virulence-associated protein has been shown to ADP-ribosylate actin, and this enzymatic activity is essential for virulence in mice. Here, we present evidence that intracellular expression of SpvB protein induces not only disruption of actin filaments but also apoptotic cell death in eukaryotic cells.
authors.affiliation: Laboratory of Molecular Immunology, Center for Basic Research, The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan.
authors.forename: Ai
authors.initials: A
authors.lastname: Kurita
authors.forename: Hideo
authors.initials: H
authors.lastname: Gotoh
authors.forename: Masahiro
authors.initials: M
authors.lastname: Eguchi
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Okada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Matsuura
authors.forename: Hidenori
authors.initials: H
authors.lastname: Matsui
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Danbara
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kikuchi
mesh_terms: D016475:3T3 Cells; D036002:ADP Ribose Transferases / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology; D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D019556:COS Cells; D002522:Chlorocebus aethiops; D020287:In Situ Nick-End Labeling; D051379:Mice; D012475:Salmonella / Q000378:metabolism* / Q000472:pathogenicity; D012480:Salmonella Infections; D014774:Virulence; D037521:Virulence Factors / Q000096:biosynthesis* / Q000502:physiology
chemical_list: D037521:Virulence Factors; D036002:ADP Ribose Transferases; C415223:spvB protein, Salmonella enterica virulence plasmid