Viruses as potential targets for therapy in HIV-associated malignancies.
Epstein-Barr virus or Kaposi's sarcoma herpesvirus--and, at times, both viruses--are present in the tumor cells of many HIV-associated malignancies. Their presence provides potential therapeutic targets for adoptive immunotherapy with antigen-specific T cells, vaccines to induce specific T-cell responses, and pharmacologic therapies to kill tumor cells or alter their malignant phenotype.
Ambinder
Richard F
RF
Hematologic Malignancies Division, Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, 1650 Orleans Street, Bunting Blaustein Building, Room 389, Baltimore, MD 21231, USA. ambinri@jhmi.edu
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000628:therapy / Q000821:virology; D015967:Gene Expression Regulation, Viral / Q000187:drug effects; D004854:Herpesvirus 4, Human / Q000235:genetics; D019288:Herpesvirus 8, Human / Q000235:genetics; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D016483:Lymphoma, AIDS-Related / Q000628:therapy / Q000821:virology; D009369:Neoplasms / Q000209:etiology / Q000628:therapy* / Q000821:virology*; D012514:Sarcoma, Kaposi / Q000628:therapy / Q000821:virology