DNA strand scission by a Cu(I).adenylated polymeric template: preliminary mechanistic and recycling studies.
Cleavage of a model phosphate ester and supercoiled plasmid DNA by a Cu(I).adenylated polymer template and preliminary mechanistic investigations are reported. A novel paradigm for the design of recyclable nucleolytic reagents allowing multiple use of this catalyst is also demonstrated
Verma
Sandeep
S
Department of Chemistry, Indian Institute of Technology-Kanpur, Kanpur 208016 (UP), India. sverma@iitk.ac.in
Srivatsan
S G
SG
Claussen
Craig A
CA
Long
Eric C
EC
D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D002384:Catalysis; D003432:Cross-Linking Reagents; D004249:DNA Damage / Q000187:drug effects*; D004278:DNA, Superhelical / Q000187:drug effects; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010710:Phosphates / Q000737:chemistry; D010957:Plasmids / Q000187:drug effects
D003432:Cross-Linking Reagents; D004278:DNA, Superhelical; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D010710:Phosphates; D000225:Adenine