title: Usefulness of high-density barium for detection of leaks after esophagogastrectomy, total gastrectomy, and total laryngectomy.
abstract: OBJECTIVE
  The purpose of this study was to determine the usefulness of a high-density (250% weight/volume) barium compared with a water-soluble contrast agent for the detection of esophageal leaks in patients who had undergone esophagogastrectomy, total gastrectomy, or total laryngectomy.
  
  
  METHODS
  A search of our radiology database from 1998 to 2001 revealed 46 eligible radiographic studies performed using a water-soluble contrast agent alone or a water-soluble contrast agent followed by barium that showed leaks in patients who had undergone esophagogastrectomy, total gastrectomy, or total laryngectomy. The images were reviewed to determine the morphology of the leaks (i.e., blind-ending tracks, sealed-off collections, or free extravasation of contrast material). Medical records were also reviewed to determine whether detection of the leaks seen on the radiographic studies affected patient management.
  
  
  RESULTS
  Of the 46 leaks seen on radiographic studies, 23 (50%) were detected with a water-soluble contrast agent and 23 (50%) were detected only with high-density barium. Of the 23 leaks visualized with water-soluble contrast media, six (26%) were characterized by blind-ending tracks, 14 (61%) by sealed-off collections, and three (13%) by free extravasation of contrast material into the mediastinum or neck. Of the 23 leaks visualized only with high-density barium, 19 (83%) were characterized by blind-ending tracks and four (17%) by sealed-off collections. Thus, leaks detected only on images obtained with high-density barium were significantly more likely to be characterized by blind-ending tracks than those detected on images obtained with a water-soluble contrast agent (p = 0.0007). Of the 33 patients with clinical follow-up, the findings seen on these imaging studies affected management in 12 (86%) of 14 patients with leaks depicted by water-soluble contrast media and in 10 (53%) of 19 with leaks depicted only by high-density barium.
  
  
  CONCLUSIONS
  Our findings support the use of high-density barium as part of the routine postoperative radiographic examination when no leaks are detected on images obtained with a water-soluble contrast agent.
authors.affiliation: Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St., Philadelphia, PA 19104, USA.
authors.forename: Jonathan O
authors.initials: JO
authors.lastname: Swanson
authors.forename: Marc S
authors.initials: MS
authors.lastname: Levine
authors.forename: Regina O
authors.initials: RO
authors.lastname: Redfern
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Rubesin
mesh_terms: D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical; D001466:Barium Sulfate; D003287:Contrast Media; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D016629:Esophagectomy; D004947:Esophagus / Q000000981:diagnostic imaging*; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D011859:Radiography; D012189:Retrospective Studies; D013535:Suspensions
chemical_list: D003287:Contrast Media; D013535:Suspensions; D003973:Diatrizoate; D001466:Barium Sulfate; D003974:Diatrizoate Meglumine