title: Effect of feeding Acacia abyssinica and of its extracts given by different routes on rats.
abstract: The effect of a diet consisting of 2% and 10% of Acacia abyssinica bark on Wistar rats treated for 6 weeks was examined. A 2% A. abyssinica diet was not toxic to rats. Impairment of growth and hepatonephropathy were observed in rats on a 10% A. abyssinica diet. By whatever route it was administered, either intraperitoneally (i.p.) or orally (p.o.), the ethyl acetate extract in daily doses of 500 mg/kg body weight was the most toxic and lethal to rats and caused hepatonephropathy, widespread hemorrhage and congestion and fibrinous peritonitis following i.p. administration. The aqueous and ethanol extracts i n similar doses to ethyl acetate extract were only lethal to rats when given via the i.p. route. Lesions were accompanied by anemia, leukopenia and alterations in serum AST activity and concentrations of urea, total protein and albumin.
authors.affiliation: College of Agriculture and Veterinary Medicine, King Saud University P.O. Box 1482, Buraidah, AL-Qassim, Saudi Arabia.
authors.forename: K N
authors.initials: KN
authors.lastname: Al-Redhaiman
authors.forename: M A
authors.initials: MA
authors.lastname: Salad
authors.forename: S E I
authors.initials: SE
authors.lastname: Adam
mesh_terms: D000045:Acacia / Q000633:toxicity*; D000818:Animals; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D004032:Diet; D004435:Eating / Q000187:drug effects; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity; D011208:Powders; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents; D015430:Weight Gain / Q000187:drug effects
chemical_list: D010936:Plant Extracts; D011208:Powders; D012997:Solvents