Acupuncture increases nitric oxide synthase expression in hippocampus of streptozotocin-induced diabetic rats.
In the present study, the effect of acupuncture at Zusanli acupoint on nitric oxide synthase (NOS) expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats was investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Animals were divided into four groups: the control group, the nondiabetic and acupunctured group, the STZ-induced diabetes group, and the STZ-induced diabetes and acupunctured group. From the results, NADPH-d-positive neurons in the hippocampus were decreased in STZ-induced diabetic rats, while acupuncture increased NOS expression significantly under diabetic conditions. In the present study, it can be suggested that acupuncture treatment may modulate NOS activity in the hippocampus under diabetic conditions.
Jang
Mi-Hyeon
MH
Department of Physiology, College of Medicine, Kyung Hee University, Dongdaemoon-gu, Seoul, Korea.
Shin
Min-Chul
MC
Lim
Baek-Vin
BV
Kim
Hyun-Bae
HB
Kim
Young-Pyo
YP
Kim
Ee-Hwa
EH
Kim
Hong
H
Shin
Mal-Soon
MS
Kim
Sung-Soo
SS
Kim
Chang-Ju
CJ
D026881:Acupuncture; D000818:Animals; D002452:Cell Count; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D006624:Hippocampus / Q000201:enzymology* / Q000502:physiology*; D006651:Histocytochemistry; D008297:Male; D009252:NADPH Dehydrogenase / Q000096:biosynthesis; D009474:Neurons / Q000201:enzymology; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D052248:Nitric Oxide Synthase Type I; D051381:Rats; D017207:Rats, Sprague-Dawley
D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; C496322:Nos1 protein, rat; D009252:NADPH Dehydrogenase