title: Immunization in tumor prevention.
abstract: Recent experimental data suggest that immunity can be activated to prevent tumors. The rationale for prevention is strong because the setting is one endowed with an immune system that is neither impaired by tumor and treatment-induced suppression, nor tolerant to tumor-associated antigens. Oncogenic growth factor receptors are tumor antigens and rational targets for specific immunoprevention. Successful prevention of mammary carcinomas in Her-2/neu transgenic mice is cited as an evidence of the validity of this approach. The specific properties of the Her-2/neu gene product as an antigen and the nature of the immune responses induced by effective preventive treatments are summarized.
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, I-10043 Orbassano, Italy. guido.forni@unito.it
authors.forename: Guido
authors.initials: G
authors.lastname: Forni
authors.forename: Claudia
authors.initials: C
authors.lastname: Curcio
authors.forename: Michela
authors.initials: M
authors.lastname: Spadaro
authors.forename: John
authors.initials: J
authors.lastname: Iliffe
authors.forename: Elena
authors.initials: E
authors.lastname: Quaglino
authors.forename: Emma
authors.initials: E
authors.lastname: Di Carlo
authors.forename: Piero
authors.initials: P
authors.lastname: Musiani
authors.forename: Pier-Luigi
authors.initials: PL
authors.lastname: Lollini
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines / Q000627:therapeutic use*; D006801:Humans; D007114:Immunization; D009369:Neoplasms / Q000276:immunology* / Q000517:prevention & control*
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines