title: Development of large genital ulcer due to hydroxyurea treatment in a patient with chronic myeloid leukemia and Behcet's disease.
abstract: Chronic myeloid leukemia (CML) is a myeloproliferative disease arising from abnormal stem cells and associated with splenomegaly and leukocytosis. Hydroxyurea and interferon alpha are used in treatment very frequently. Behcet's disease (BD) is a chronic, repetitive disease of unknown etiology and associated with mucocutaneous, ocular, vascular and central nervous system involvement. Cases with symptoms of BD have been reported during interferon alpha treatment of CML. However, similar symptoms due to hydroxyurea treatment have been reported in only one case until now. A 32-year-old female patient under follow up because of CML and BD, developed a large genital ulcer during hydroxyurea treatment. Ulcers due to hydroxyurea treatment and the co-existence of these two diseases has been reported in only one case in the literature while large genital ulcers have not been reported previously.
authors.affiliation: Department of Dermatology, Turgut Ozal Medical Center, Inonu University, 44069 Malatya, Turkey. ykarincaoglu@inonu.edu.tr
authors.forename: Yelda
authors.initials: Y
authors.lastname: Karincaoglu
authors.forename: Emin
authors.initials: E
authors.lastname: Kaya
authors.forename: Muammer
authors.initials: M
authors.lastname: Esrefoglu
authors.forename: Ismet
authors.initials: I
authors.lastname: Aydogdu
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001528:Behcet Syndrome / Q000150:complications*; D005260:Female; D005831:Genital Diseases, Female / Q000139:chemically induced*; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy*; D014456:Ulcer / Q000139:chemically induced
chemical_list: D000970:Antineoplastic Agents; D006918:Hydroxyurea