Spatial vision in visually asymptomatic subjects at high risk for multiple sclerosis.
OBJECTIVE
To investigate the state of spatial vision in visually asymptomatic subjects at high risk for multiple sclerosis.


METHODS
Fifteen subjects suffering a first neurological episode suggestive of multiple sclerosis in clinical presentation, immunological profile, and magnetic resonance imaging, were examined with a new, sensitive test of spatial vision, rarebit perimetry. None had symptoms or signs of optic neuropathy.


RESULTS
Results of rarebit perimetry were significantly worse than those of 15 age matched normal controls (p=0.01); seven patients (47%) were outside normal limits. One patient only obtained abnormal results in high pass resolution perimetry.


CONCLUSIONS
Rarebit perimetry may help to close the sensitivity gap between clinical examinations and neuroimaging.
Frisén
L
L
Institute of Clinical Neuroscience, Sahlgren's Academy of Göteborg University, Sahlgren's Hospital, S-413 45 Göteborg, Sweden. lars.frisen@neuro.gu.se
D000208:Acute Disease; D000328:Adult; D001921:Brain / Q000473:pathology; D003196:Computer Graphics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis*; D009460:Neurologic Examination; D009902:Optic Neuritis / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012016:Reference Values; D058609:Visual Field Tests