Total synthesis of apratoxin A.
Apratoxin A, a cyclodepsipeptide isolated from cyanobacterial Lyngbya spp, has been synthesized. The total synthesis features stereocontrolled access to the novel polyketide and the late-stage installation of the sensitive 2,4-disubstituted thiazoline moiety using an intramolecular Staudinger reduction/aza-Wittig process.
Chen
Jiehao
J
Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Forsyth
Craig J
CJ
D003603:Cytotoxins / Q000138:chemical synthesis*; D047630:Depsipeptides; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D013237:Stereoisomerism
D003603:Cytotoxins; D047630:Depsipeptides; D010456:Peptides, Cyclic; C442201:apratoxin A