Lack of de-epoxidation of type B trichothecenes in incubates with human faeces.
The ability of human gastrointestinal organisms to transform the trichothecenes 3-acetyldeoxynivalenol and nivalenol was investigated. Samples of human faeces were incubated under anaerobic conditions for 48 h with the toxins. They were then extracted and analysed for trichothecenes and metabolites. 3-acetyldeoxynivalenol was metabolized to deoxynivalenol during the incubation period. In contrast to what has been reported for other species such as rats, mice and pigs, no de-epoxidated metabolites were detected in the faecal incubates. The toxicological significance of the difference in the intestinal ability to transform trichothecenes between species is unknown.
Sundstøl Eriksen
G
G
Department of Animal Nutrition and Management, Swedish University of Agricultural Sciences, Uppsala, Sweden. gunnar.sundstol-eriksen@huv.slu.se
Pettersson
H
H
D000328:Adult; D000818:Animals; D004852:Epoxy Compounds / Q000493:pharmacokinetics; D005243:Feces / Q000737:chemistry* / Q000382:microbiology; D005260:Female; D005506:Food Contamination; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018570:Risk Assessment; D013045:Species Specificity; D014255:Trichothecenes / Q000493:pharmacokinetics*
D004852:Epoxy Compounds; D014255:Trichothecenes; C043247:3-acetyldeoxynivalenol; C038405:nivalenol