Role of HIV-1 Gag domains in viral assembly.
After entry of the human immunodeficiency virus type 1 (HIV-1) into T cells and the subsequent synthesis of viral products, viral proteins and RNA must somehow find each other in the host cells and assemble on the plasma membrane to form the budding viral particle. In this general review of HIV-1 assembly, we present a brief overview of the HIV life cycle and then discuss assembly of the HIV Gag polyprotein on RNA and membrane substrates from a biochemical perspective. The role of the domains of Gag in targeting to the plasma membrane and the role of the cellular host protein cyclophilin are also reviewed.
Scarlata
Suzanne
S
Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, NY 11794-8661, USA. suzanne@dualphy.pnb.sunysb.edu
Carter
Carol
C
D000595:Amino Acid Sequence; D002462:Cell Membrane / Q000821:virology; D021983:Cyclophilins / Q000378:metabolism; D015683:Gene Products, gag / Q000737:chemistry* / Q000378:metabolism; D016679:Genome, Viral; D015497:HIV-1 / Q000235:genetics / Q000254:growth & development* / Q000472:pathogenicity; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D014771:Virion / Q000254:growth & development
D015683:Gene Products, gag; D021983:Cyclophilins