[Study of sexual hormone changes in prostate cancer patients before and after androgen deprivation therapy].
OBJECTIVE
To investigate and observe serum sexual hormone (testosterone, T; free testosterone, FT; dihydrotestosterone, DHT) changes in patients with prostate cancer (PCa) before and after androgen deprivation.


METHODS
Serum T, FT, DHT were measured with radioimmunoassay in 16 cases with PCa respectively one week before and the fifth day after androgen deprivation. The changes of T, FT, DHT were analyzed.


RESULTS
Serum T, FT, DHT declined 92.27%, 92.26%, 58.36% respectively. They were statistically significant before and after androgen deprivation (P < 0.001).


CONCLUSIONS
After androgen deprivation, most T and FT were deprived while DHT declined 58.36% only. Androgen receptor competitor shall be applied continually to prohibit the action of remnant androgen.
Ying
Jun
J
Department of Urology, Shanghai Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
Yao
De-Hong
DH
Ren
Xiao-Ming
XM
D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use*; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000628:therapy*
D000726:Androgen Antagonists; D012739:Gonadal Steroid Hormones