[Neuropeptide thyroliberin in ultra low doses--anticonvulsant defense of the brain].
Thyroliberin (TRH) promoting endogeneous antidepressive effect is the most general regulator of the central mechanisms and visceral functions (especially respiration). Our group pioneered in applying the anticonvulsant action of TRH after local intranasal application). This application of TRH in ultra-low doses contrast the method of systemic TRH administration in the large doses). In our experiments intranasal application of 10(-8), 10(-10) and 10(-12) mol/l TRH significantly inhibited the severe epileptic motor fits in rats induced by PTZ. EEG also confirms beneficent effect of TRH (TRH suppressed SWD in cortex, amygdala and hippocamp). In the experiment that follows compared effects of TRH (pyroGlu-His-Pro-NH2) and its metabolite dipeptide His-Pro (10(-10), 10(-8) mol/l). The experiments make more precise that only TRH but not His-Pro posses the anticonvulsant properties. There is a good believe that medical potentialities of TRH have not been exhausted and its new possibilities of its usage will be revealed in epileptology.
Ashmarin
I P
IP
Lomonosov Moscow State University, Moscow, 119899 Russia.
Asanova
L M
LM
Abbasova
K R
KR
Chepurnova
N E
NE
Kossova
G V
GV
Chepurnov
S A
SA
Iniushkin
A N
AN
Goncharov
O B
OB
D000281:Administration, Intranasal; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000502:physiology*; D003292:Convulsants / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D008297:Male; D010433:Pentylenetetrazole / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*
D000927:Anticonvulsants; D003292:Convulsants; D013973:Thyrotropin-Releasing Hormone; D010433:Pentylenetetrazole