title: Influence of new gamma-hydroxybutyric acid amide analogues on the central nervous system activity in mice.
abstract: The present study investigates the activity of four gamma-hydroxybutyric acid amide analogues (BM-68, BM-74, BM-75 and BM-76) in two models of chemically induced seizures, i.e. picrotoxin- and pentetrazole-induced seizures and in the thiopental-induced sleep test. The results of pharmacological in vivo experiments with the gamma-hydroxybutyric acid amide analogues presented below show that the compounds possess variable influence on the central nervous system in mice.
authors.affiliation: Department of Pharmacodynamics, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Kraków, Poland.
authors.forename: Kinga
authors.initials: K
authors.lastname: Sałat
authors.forename: Anna
authors.initials: A
authors.lastname: Mendyk
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Librowski
authors.forename: Ryszard
authors.initials: R
authors.lastname: Czarnecki
authors.forename: Barbara
authors.initials: B
authors.lastname: Malawska
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology; D006885:Hydroxybutyrates / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012890:Sleep / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D006885:Hydroxybutyrates; C111420:4-hydroxybutyric acid; D005680:gamma-Aminobutyric Acid