title: Rhodium-catalyzed enantioselective diboration of simple alkenes.
abstract: Enantioselective catalytic reactions that operate directly on inexpensive unactivated alkenes are extraordinarily useful for the preparation of chiral organic building blocks and new materials. While a number of such processes have been developed, our ability to meet the intensifying demand for inexpensive stereochemically complex materials will require a significant expansion of practical catalytic asymmetric reaction methodology. In this regard, the rhodium-catalyzed enantioselective diboration reaction has been developed in order to address a number of extant problems in catalytic alkene transformation simultaneously. This process provides an enantiomerically enriched reactive dimetalated intermediate which can be converted to a variety of difunctional reaction products.
authors.affiliation: Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.
authors.forename: Jeremy B
authors.initials: JB
authors.lastname: Morgan
authors.forename: Steven P
authors.initials: SP
authors.lastname: Miller
authors.forename: James P
authors.initials: JP
authors.lastname: Morken
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis*; D000475:Alkenes / Q000737:chemistry*; D001880:Boranes / Q000737:chemistry*; D002384:Catalysis; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000475:Alkenes; D001880:Boranes; D012238:Rhodium