Angiotensin converting enzyme (ACE) inhibitory alkaloids from Fritillaria ussuriensis.
Bioassay-guided fractionation of the BuOH-soluble extract of Fritillaria ussuriensis afforded verticinone ( 1), verticine ( 2), and peimisine ( 3). Purification of these compounds was achieved with the use of various chromatographic methods. The structures of the compounds were identified on the basis of MS and NMR data analysis. Compounds 1 - 3 inhibited angiotensin I converting enzyme activity in a dose-dependent manner, displaying 50 % inhibitory concentration values of 165.0 microM, 312.8 microM, 526.5 microM, respectively. The presence of these active substances may be responsible, at least in part, for the antihypertensive action of the bulbs of Fritillaria ussuriensis.
Oh
Hyuncheol
H
Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, Republic of Korea.
Kang
Dae-Gill
DG
Lee
Sunyoung
S
Lee
Yunmi
Y
Lee
Ho-Sub
HS
D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002595:Cevanes / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D031410:Fritillaria; D006801:Humans; D020128:Inhibitory Concentration 50; D007703:Peptidyl-Dipeptidase A / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000470:Alkaloids; D000806:Angiotensin-Converting Enzyme Inhibitors; D002595:Cevanes; D010936:Plant Extracts; C052510:peimisine; C014242:verticine; D007703:Peptidyl-Dipeptidase A