title: Effect of recombinant human basic fibroblast growth factor on angiogenesis during mandible fracture healing in rabbits.
abstract: OBJECTIVE
  To investigate the effect of recombinant human basic fibroblast growth factor (rhbFGF) on angiogenesis during mandible fracture healing in rabbit.
  
  
  METHODS
  Fifty adult white rabbits were used for animal model and randomly divided into a control group (25 rabbits) and an experimental group (25 rabbits). The membranous complex of rhbFGF and bovine type I collagen was prepared and implanted into the rabbit mandible fracture site under periosteum. The animals were sacrificed on 7, 14, 28, 56 and 84 days respectively after operation and the whole mandibles were harvested. The expression of factor VIII related antigen (F8-RA) in callus was examined with immunohistochemical staining.
  
  
  RESULTS
  The amounts of microvascular formation in calluses in the rhbFGF-treating group on days 7, 14, 28 and 56 were more than those of the control group (P<0.01).
  
  
  CONCLUSIONS
  The results indicated that rhbFGF could stimulate microvascular formation during mandible fracture healing in rabbits.
authors.affiliation: Department of Oral-Maxillofacial Surgery, College of Stomatology, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Zhen-yu
authors.initials: ZY
authors.lastname: Gong
authors.forename: Shu-xia
authors.initials: SX
authors.lastname: Zhou
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Gu
authors.forename: Di-chen
authors.initials: DC
authors.lastname: Li
authors.forename: Ming-lin
authors.initials: ML
authors.lastname: Sun
mesh_terms: D000818:Animals; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D017102:Fracture Healing / Q000502:physiology*; D008337:Mandibular Fractures / Q000503:physiopathology*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D011817:Rabbits; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D011994:Recombinant Proteins; D016222:Fibroblast Growth Factor 2