title: Response of a neotenic goby, ice goby (Leucopsarion petersii), to thyroid hormone and thiourea treatments.
abstract: In order to clarify the mechanisms of neoteny in the ice goby (Leucopsarion petersii), we examined effects of thyroid hormone and thiourea (TU) treatments on their neotenic characteristics and the pituitary-thyroid axis. Adult ice goby were exposed to 3, 5, 3'-triiodothyronine (T3, 0.1 ppm), TU (inhibitor of thyroid hormone synthesis, 30 ppm), or the combination of the two for 2 weeks. Observations of whole body T3 levels, thyroid follicles and TSH immunoreactive cells in the pituitary suggests the presence of a functioning thyroidal system. However, all of the neotenic features did not disappear in T3-treated fish, suggesting the absence of T3 responsiveness in peripheral tissues. These results indicate the similarity between neoteny of the ice goby and obligatory-type neoteny of urodeles.
authors.affiliation: Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan. yasuko@kais.kyoto-u.ac.jp
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Harada
authors.forename: Izumi
authors.initials: I
authors.lastname: Kinoshita
authors.forename: Toyoji
authors.initials: T
authors.lastname: Kaneko
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Moriyama
authors.forename: Masaru
authors.initials: M
authors.lastname: Tanaka
authors.forename: Masatomo
authors.initials: M
authors.lastname: Tagawa
mesh_terms: D000818:Animals; D007150:Immunohistochemistry; D009024:Morphogenesis / Q000187:drug effects; D010473:Perciformes / Q000254:growth & development* / Q000378:metabolism*; D010902:Pituitary Gland / Q000187:drug effects*; D013890:Thiourea / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects*; D014284:Triiodothyronine / Q000494:pharmacology*
chemical_list: D014284:Triiodothyronine; D013890:Thiourea