title: Goal-directed, serial and synchronous activation of neurons in the primate striatum.
abstract: To study roles of cortico-basal ganglia loops in action planning, we examined interactions between the activities of simultaneously recorded neurons in the striatum of monkeys performing sequence motor tasks by cross-correlation analysis. Serial activation occurred between projection neurons in a motor sequence-dependent manner, and was in the direction of a neuron encoding an early event in the sequence to a neuron encoding the same event or later, but closer event to the reward. Synchronous activation occurred between pairs of interneurons. The serial activation seems to originate through the cortico-basal ganglia loops, because projection neurons are inhibitory. We propose that the task-dependent serial and synchronous activation of striate neurons may be a neural substrate for goal-directed planning through the basal ganglia.
authors.affiliation: Department of Physiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. mkimura@basic.kpu-m.ac.jp
authors.forename: Minoru
authors.initials: M
authors.lastname: Kimura
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Matsumoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Okahashi
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Ueda
authors.forename: Takemasa
authors.initials: T
authors.lastname: Satoh
authors.forename: Takafumi
authors.initials: T
authors.lastname: Minamimoto
authors.forename: Masashi
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamada
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology; D003342:Corpus Striatum / Q000166:cytology / Q000502:physiology*; D004594:Electrophysiology; D006040:Goals; D000882:Haplorhini; D009043:Motor Activity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*