title: Intracellular Ca2+ signaling and human disease: the hunt begins with Huntington's.
abstract: Huntingtin, a protein altered by polyglutamine expansion in Huntington's disease (Httexp), forms a signaling complex with the InsP3R, an intracellular calcium channel, and Htt-associated protein 1A (HAP1A). The addition of Httexp increases the InsP3R sensitivity to InsP3, which subsequently makes neurons hyperresponsive to stimulation and presumably more prone to neurodegenerative processes.
authors.affiliation: Department of Pharmacology and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Anurag
authors.initials: A
authors.lastname: Varshney
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Ehrlich
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D002118:Calcium