title: Bovine lactoferrin inhibits adenovirus infection by interacting with viral structural polypeptides.
abstract: We recently demonstrated that lactoferrin, an antimicrobial glycoprotein, can inhibit adenovirus infection by competing for common glycosaminoglycan receptors. This study further characterizes the antiadenovirus activity of the protein, thus demonstrating that lactoferrin neutralizes infection by binding to adenovirus particles and that its targets are viral III and IIIa structural polypeptides.
authors.affiliation: Department of Ultrastructure, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Agostina
authors.initials: A
authors.lastname: Pietrantoni
authors.forename: Assunta Maria
authors.initials: AM
authors.lastname: Di Biase
authors.forename: Antonella
authors.initials: A
authors.lastname: Tinari
authors.forename: Magda
authors.initials: M
authors.lastname: Marchetti
authors.forename: Piera
authors.initials: P
authors.lastname: Valenti
authors.forename: Lucilla
authors.initials: L
authors.lastname: Seganti
authors.forename: Fabiana
authors.initials: F
authors.lastname: Superti
mesh_terms: D000256:Adenoviridae / Q000737:chemistry / Q000187:drug effects* / Q000648:ultrastructure; D000258:Adenovirus Infections, Human / Q000188:drug therapy*; D000818:Animals; D000956:Antigens, Viral / Q000096:biosynthesis / Q000235:genetics; D001710:Biotin / Q000737:chemistry; D002417:Cattle; D004591:Electrophoresis, Polyacrylamide Gel; D004770:Enterovirus / Q000737:chemistry / Q000187:drug effects / Q000648:ultrastructure; D007781:Lactoferrin / Q000494:pharmacology / Q000627:therapeutic use*; D008854:Microscopy, Electron; D010455:Peptides / Q000737:chemistry / Q000187:drug effects*; D014407:Tumor Cells, Cultured
chemical_list: D000956:Antigens, Viral; D010455:Peptides; D001710:Biotin; D007781:Lactoferrin