[Autologous blood procurement--acute normovolemic hemodilution vs. preoperative autologous blood donation].
Autologous blood procurement remains in evolution. Interest in preoperative autologous blood donation (PAD) increased substantially in the 1980's due to the recognition that HIV was transmissible by blood. Concomitant with increased blood safety, however, PAD activity has declined approximately 40% since 1992. Reasons for this decline are unclear; patients may feel more comfortable with issues regarding blood safety, but associated costs and discard rates of up to 50% of blood units are other important factors. An alternate strategy is acute normovolemic hemodilution (ANH), which has the advantages of lower costs along with no wastage of blood units. A further advantage is that since ANH units never leave the patient's bedside, there is no possibility of an administrative error that could lead to ABO-related hemolysis (as could occur with PAD units stored in the blood bank). Concerns regarding the adequacy of national blood inventories may restimulate interest in autologous blood procurement, independent of issues regarding blood risks or costs.
Goodnough
L T
LT
Medicine, Pathology and Immunology, Division of Laboratory Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. goodnough@labmed.wustl.edu
D019644:Arthroplasty, Replacement, Hip; D001771:Blood Banks; D001804:Blood Transfusion, Autologous / Q000191:economics; D001810:Blood Volume; D003365:Costs and Cost Analysis; D006400:Hematocrit; D006438:Hemodilution / Q000191:economics / Q000379:methods; D006801:Humans; D008297:Male; D008962:Models, Theoretical; D018579:Patient Selection; D011300:Preoperative Care; D011468:Prostatectomy; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013997:Time Factors