[The effect of retabolil and support loads on atrophied muscles in suspended rats].
In experiments with rats histological and morphometric methods were employed to study effects of anabolic steroid rhetabolil and a combination of rhetabolil with predetermined support loads on development of atrophy in m. soleus and m. gastrocnemius. Muscular atrophy was provoked by tail suspension of rats for a period of 30 days. Rhetabolil was injected once a week I/M at a total dose of 10 mg per 100 g of the body mass. The experiment showed that this dose of rhetabolil had no effect on atrophy development; neither it amplified the favorable effect of support loads observed in earlier experiments with injection of small doses of rhetabolil. A supposition was made that the anti-atrophy effects of rhetabolil combined with the support loads are dose dependent. It was concluded that large doses of rhetabolil do not activate anabolic processes in the load-deprived muscles.
Il'ina-Kakueva
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D045930:Anabolic Agents / Q000008:administration & dosage*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D019417:Hindlimb Suspension; D008297:Male; D009133:Muscular Atrophy / Q000188:drug therapy*; D009277:Nandrolone / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D000077603:Nandrolone Decanoate; D011187:Posture; D051381:Rats; D017208:Rats, Wistar; D016474:Weight-Bearing
D045930:Anabolic Agents; D009277:Nandrolone; D000077603:Nandrolone Decanoate