title: Very high risk of therapeutic failure with chloroquine for uncomplicated Plasmodium falciparum and P. vivax malaria in Indonesian Papua.
abstract: Chloroquine remains the first-line therapy for uncomplicated malaria in Indonesia. Among a series of trials of chloroquine for malaria on this archipelago conducted since 1990, we now report the highest risk of therapeutic failure yet observed. A clinical trial of standard chloroquine therapy for uncomplicated malaria at Arso PIR V in northeastern Indonesian Papua was conducted during 1995. We enrolled 104 non-immune subjects infected with Plasmodium falciparum (n = 55), P. vivax (n = 29), or P. falciparum plus P. vivax (n = 20) and administered supervised standard chloroquine therapy (10 + 10 + 5 mg/kg at 24-hour intervals). The 28-day cumulative incidence of therapeutic failure was 95% for P. falciparum, 84% for P. vivax, and 100% for mixed infections. Only one subject each for P. falciparum and P. vivax remained free of parasites at day 28. All recurrent parasitemias occurred with whole blood levels of chloroquine plus desethylchloroquine exceeding 100 ng/ml. These findings document almost complete failure of chloroquine against P. falciparum or P. vivax near the northeastern coast of Indonesian Papua.
authors.affiliation: United States Naval Medical Research Unit No. 2, American Embassy, Jakarta, Indonesia.
authors.forename: Iwa W
authors.initials: IW
authors.lastname: Sumawinata
authors.lastname: Bernadeta
authors.forename: Budhi
authors.initials: B
authors.lastname: Leksana
authors.forename: Awalludin
authors.initials: A
authors.lastname: Sutamihardja
authors.lastname: Purnomo
authors.forename: Budi
authors.initials: B
authors.lastname: Subianto
authors.lastname: Sekartuti
authors.forename: David J
authors.initials: DJ
authors.lastname: Fryauff
authors.forename: J Kevin
authors.initials: JK
authors.lastname: Baird
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000097:blood / Q000191:economics / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000031:analogs & derivatives* / Q000097:blood / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D007214:Indonesia; D015993:Life Tables; D016778:Malaria, Falciparum / Q000188:drug therapy*; D016780:Malaria, Vivax / Q000188:drug therapy*; D018512:Parasitemia / Q000188:drug therapy / Q000469:parasitology; D012008:Recurrence; D012307:Risk Factors; D017211:Treatment Failure
chemical_list: D000962:Antimalarials; D002738:Chloroquine; C007278:desethylchloroquine