[Pharmacokinetics of vancomycin in continuous veno-venous hemofiltration].
OBJECTIVE
To investigate the pharmacokinetics of vancomycin in continuous veno-venous hemofiltration(CVVH) in order to determine appropriate vancomycin dosing strategies for patients receiving CVVH.


METHODS
The serum concentrations of vancomycin were measured by TDx and the pharmacokinetics parameters were calculated.


RESULTS
The pharmacokinetics of vancomycin during CVVH was fitted with open two-compartment model. At the beginning of CVVH, the pharmacokinetic parameters were: maximum plasma concentration (Cmax)=22.18 mg/L, minimum plasma concentration attained (Cmin)=5.82 mg/L, half-life of drug (T1/2)=5.75 h, apparent volume of distribution (Vd)=21.92 L, total body clearance of drug(CL)=3.49 L/h. On the 16 d of CVVH, the pharmacokinetic parameters were Cmax=38.70 mg/L, Cmin=16.50 mg/L, T1/2=33.32 h, Vd=12.92 L, CL=0.38 L/h.


CONCLUSIONS
CVVH can significantly augment the clearance of vancomycin in acute renal failure patients. Dosing strategies for individualization of vancomycin therapy in patients receiving CVVH are proposed. Monitoring the serum concentration during CVVH is necessary.
Gu
Qin
Q
Department of Intensive Care Unit, The Medical College of Nanjing University Affiliated Drum-Tower Hospital, Nanjing 210008, Jiangsu, China.
Zhu
Zhang-hua
ZH
Ge
Min
M
Ge
Wei-hong
WH
D006207:Half-Life; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods; D014640:Vancomycin / Q000493:pharmacokinetics* / Q000627:therapeutic use*
D014640:Vancomycin