title: Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetes.
abstract: Type 1 diabetes of both the NOD mouse and man is associated with autoimmunity directed against insulin which is the only beta cell specific autoantigen identified to date. One can use autoantibodies to insulin to predict diabetes, use insulin peptides to create insulin autoantibodies, insulitis and diabetes, and use insulin or its peptides in animal models to prevent diabetes. An expanding set of resources are now available for the development and testing in man of therapies to prevent type 1 diabetes, and a number of trials utilizing insulin peptides are now underway.
authors.affiliation: Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B-140, Denver, CO 80262, USA. george.eisenbarth@uchsc.edu
authors.forename: George S
authors.initials: GS
authors.lastname: Eisenbarth
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Moriyama
authors.forename: David T
authors.initials: DT
authors.lastname: Robles
authors.forename: Edwin
authors.initials: E
authors.lastname: Liu
authors.forename: Liping
authors.initials: L
authors.lastname: Yu
authors.forename: Sunanda
authors.initials: S
authors.lastname: Babu
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Redondo
authors.forename: Maria
authors.initials: M
authors.lastname: Redondo
authors.forename: Peter
authors.initials: P
authors.lastname: Gottlieb
authors.forename: Dale
authors.initials: D
authors.lastname: Wegmann
authors.forename: Marian
authors.initials: M
authors.lastname: Rewers
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000235:genetics / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007328:Insulin / Q000276:immunology*; D007330:Insulin Antibodies / Q000235:genetics / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000276:immunology; D051379:Mice; D016688:Mice, Inbred NOD
chemical_list: D001323:Autoantibodies; D007328:Insulin; D007330:Insulin Antibodies