Use of atropine to reduce mucosal eversion during intestinal resection and anastomosis in the dog.
OBJECTIVE
To determine whether atropine altered the degree of mucosal eversion during jejunal resection and anastomosis in the dog.


METHODS
Part I: Prospective, blinded, randomized, controlled study using a therapeutic dose (0.04 mg/kg systemic) of atropine. Part II: Prospective, unblinded, assigned, controlled study using a pharmacologic (0.04 mg/kg local arterial) dose of atropine.


METHODS
Part I: Twenty-two young adult female Beagle dogs used during a nonsurvival third-year veterinary student surgical laboratory (small intestinal resection and anastomosis). Part II: Ten young adult female Beagle dogs used immediately after completion of a nonsurvival third-year veterinary student orthopedic surgical laboratory.


METHODS
Part I: Dogs were randomly assigned to receive either atropine (0.04 mg/kg), or an equal volume of saline, given intramuscularly (premedication) and again intravenously prior to intestinal resection. Part II: In each dog, atropine (0.04 mg/kg)/saline was alternately given in the proximal/distal jejunum.


RESULTS
Part I: There was no clinically or statistically significant difference between systemic atropine and saline solution on the degree of jejunal mucosal eversion after resection. Part II: There was a statistically significant decrease in jejunal mucosal eversion with atropine compared with saline solution when injected into a local jejunal artery.


CONCLUSIONS
Systemic atropine (0.04 mg/kg) does not alter the degree of jejunal mucosal eversion during resection and anastomosis. Jejunal intraarterial atropine (0.04 mg/kg) reduced jejunal mucosal eversion during resection and anastomosis.


CONCLUSIONS
The clinical usefulness and consequences of jejunal arterial atropine administration to reduce mucosal eversion remain to be determined.
Agrodnia
Marta
M
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
Hauptman
Joe
J
Walshaw
Richard
R
D000714:Anastomosis, Surgical / Q000379:methods / Q000662:veterinary*; D000818:Animals; D001158:Arteries; D001285:Atropine / Q000008:administration & dosage*; D004285:Dogs / Q000601:surgery*; D004334:Drug Administration Schedule; D005260:Female; D007267:Injections / Q000662:veterinary; D007413:Intestinal Mucosa / Q000473:pathology*; D007583:Jejunum / Q000473:pathology / Q000601:surgery*; D018727:Muscarinic Antagonists / Q000008:administration & dosage*; D011446:Prospective Studies; D016037:Single-Blind Method; D013536:Suture Techniques / Q000662:veterinary; D016896:Treatment Outcome
D018727:Muscarinic Antagonists; D001285:Atropine