title: [Nedaplatin and 5-fluorouracil combined with radiotherapy for advanced esophageal cancer].
abstract: We conducted a pilot study of nedaplatin + 5-fluorouracil (5-FU) combined with radiotherapy for 29 patients with primary advanced (stage IV) esophageal cancer. A complete remission (CR) was obtained in 4 (14%) and a partial response in 13 patients (response rate: 59%). The median survival time and one-year survival rate were 238 days and 34.5%, respectively. Of the 29 patients, 24 (83%) completed the treatment schedule and toxicity of stomatitis and the like was infrequent. In conclusion, these results suggest that the efficacy of nedaplatin + 5-FU combined with radiotherapy might not differ from that of cisplatin + 5-FU combined with radiotherapy. Clearly, the usefulness of this combined therapy needs to be assessed in multicenter phase III trials.
authors.affiliation: Dept. of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakamura
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ide
authors.forename: Reiki
authors.initials: R
authors.lastname: Eguchi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hayashi
authors.forename: Masaho
authors.initials: M
authors.lastname: Ota
authors.forename: Kosuke
authors.initials: K
authors.lastname: Narumiya
authors.forename: Ken
authors.initials: K
authors.lastname: Takasaki
authors.forename: Masao
authors.initials: M
authors.lastname: Mitsuhashi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D010865:Pilot Projects; D011879:Radiotherapy Dosage
chemical_list: D009944:Organoplatinum Compounds; C053989:nedaplatin; D005472:Fluorouracil