Guar attenuates fall in postprandial blood pressure and slows gastric emptying of oral glucose in type 2 diabetes.
Postprandial hypotension occurs frequently in diabetes; the fall in blood pressure is greatest after ingestion of carbohydrate, particularly glucose and, in type 2 diabetes, is related to the rate of gastric emptying. The aim of this study was to determine whether slowing of gastric emptying by guar gum reduces the fall in blood pressure after oral glucose in patients with type 2 diabetes. Eleven type 2 patients managed by diet alone, age 61.9 +/- 1.3 years, had measurements of gastric emptying, blood pressure, blood glucose, and serum insulin on two occasions after ingestion of 300 ml water containing 50 g glucose, with or without 9 g guar gum. The magnitude of the fall in blood pressure was less (P < 0.05) and gastric emptying slower (P < 0.05) after guar. Blood glucose (P < 0.05) and serum insulin (P < 0.01) concentrations were lower after guar. The magnitude of the fall in systolic blood pressure was related to gastric emptying of glucose at 30 min on the control day (r = 0.67, P < 0.05). We conclude that guar gum attenuates the fall in blood pressure after oral glucose in patients with type 2 diabetes mellitus, presumably by slowing glucose absorption.
Russo
Antonietta
A
Department of Medicine, Royal Adelaide Hospital, University of Adelaide, South Australia, Australia, 5000.
Stevens
Julie E
JE
Wilson
Toni
T
Wells
Fiona
F
Tonkin
Anne
A
Horowitz
Michael
M
Jones
Karen L
KL
D000284:Administration, Oral; D000368:Aged; D001786:Blood Glucose / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D005685:Galactans / Q000494:pharmacology / Q000627:therapeutic use*; D005746:Gastric Emptying / Q000187:drug effects* / Q000502:physiology; D005947:Glucose / Q000008:administration & dosage* / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007022:Hypotension / Q000150:complications / Q000188:drug therapy*; D007328:Insulin / Q000097:blood; D008351:Mannans / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D053149:Plant Gums; D028321:Plant Preparations / Q000627:therapeutic use; D019518:Postprandial Period
D001786:Blood Glucose; D005685:Galactans; D007328:Insulin; D008351:Mannans; D053149:Plant Gums; D028321:Plant Preparations; C007894:guar gum; D005947:Glucose