title: A randomized placebo-controlled trial of arthroscopic lavage versus lavage plus intra-articular corticosteroids in the management of symptomatic osteoarthritis of the knee.
abstract: OBJECTIVE
  To assess the efficacy of intra-articular steroid injections following arthroscopy and joint lavage in symptomatic OA of the knee.
  
  
  METHODS
  Seventy-seven patients with OA of the knee were randomized to receive either 120 mg methylprednisolone acetate (MPA) or placebo following arthroscopy. Clinical assessments included severity of pain on movement and at rest, stiffness, the presence of joint effusions, range of movement, WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) score and Lequesne functional assessment. The outcome measures were evaluated at baseline and 2, 4, 8, 12 and 24 weeks. Further arthroscopies and synovial biopsies were performed at the time of clinical response and at relapse.
  
  
  RESULTS
  An intention-to-treat analysis was performed on 71 patients (38 MPA, 33 placebo). Using the OARSI (Osteoarthritis Research Society International) response criteria, 58% of the steroid group vs 33% of the placebo group (adjusted relative risk = 2.38) (P = 0.004) responded at 4 weeks. At other time points, there were no significant differences between the treatment groups. There were no significant differences between the two treatment groups for pain, stiffness or WOMAC or Lequesne assessments at any time point.
  
  
  CONCLUSIONS
  The response to intra-articular corticosteroids following joint lavage is short-lived (2-4 weeks), achievement of an OARSI response criterion being the only difference between the two groups.
authors.affiliation: Rheumatology Unit, Repatriation General Hospital, Daw Park, South Australia.
authors.forename: M D
authors.initials: MD
authors.lastname: Smith
authors.forename: M
authors.initials: M
authors.lastname: Wetherall
authors.forename: T
authors.initials: T
authors.lastname: Darby
authors.forename: A
authors.initials: A
authors.lastname: Esterman
authors.forename: J
authors.initials: J
authors.lastname: Slavotinek
authors.forename: P
authors.initials: P
authors.lastname: Roberts-Thomson
authors.forename: M
authors.initials: M
authors.lastname: Coleman
authors.forename: M J
authors.initials: MJ
authors.lastname: Ahern
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000368:Aged; D001182:Arthroscopy / Q000009:adverse effects; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008775:Methylprednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000077555:Methylprednisolone Acetate; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000188:drug therapy* / Q000601:surgery; D010147:Pain Measurement; D016059:Range of Motion, Articular; D012008:Recurrence; D012720:Severity of Illness Index; D007507:Therapeutic Irrigation / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000077555:Methylprednisolone Acetate; D008775:Methylprednisolone