The mitochondrial voltage-dependent anion channel (VDAC) as a therapeutic target for initiating cell death.
Voltage-dependent anion channels (VDAC) are major constituents of the outer mitochondrial membrane. Over the past few years, several hypotheses and mechanisms have been forwarded for and against a role for VDAC in outer mitochondrial membrane permeability and the subsequent release of apoptosis promoting factors. The current review outlines current knowledge related to the role of VDAC in the regulation of cell death and speculates on possible therapeutic applications through VDAC modulation.
Granville
David J
DJ
The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Gottlieb
Roberta A
RA
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D045304:Cytochromes c / Q000378:metabolism; D018260:Gelsolin / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism*; D007473:Ion Channels / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D018272:Porins / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism / Q000494:pharmacology; D050994:Voltage-Dependent Anion Channels
D018260:Gelsolin; D007473:Ion Channels; D018272:Porins; D011518:Proto-Oncogene Proteins; D017382:Reactive Oxygen Species; D014764:Viral Proteins; D050994:Voltage-Dependent Anion Channels; D045304:Cytochromes c; D002118:Calcium