title: Use of atropine to reduce mucosal eversion during intestinal resection and anastomosis in the dog.
abstract: OBJECTIVE
  To determine whether atropine altered the degree of mucosal eversion during jejunal resection and anastomosis in the dog.
  
  
  METHODS
  Part I: Prospective, blinded, randomized, controlled study using a therapeutic dose (0.04 mg/kg systemic) of atropine. Part II: Prospective, unblinded, assigned, controlled study using a pharmacologic (0.04 mg/kg local arterial) dose of atropine.
  
  
  METHODS
  Part I: Twenty-two young adult female Beagle dogs used during a nonsurvival third-year veterinary student surgical laboratory (small intestinal resection and anastomosis). Part II: Ten young adult female Beagle dogs used immediately after completion of a nonsurvival third-year veterinary student orthopedic surgical laboratory.
  
  
  METHODS
  Part I: Dogs were randomly assigned to receive either atropine (0.04 mg/kg), or an equal volume of saline, given intramuscularly (premedication) and again intravenously prior to intestinal resection. Part II: In each dog, atropine (0.04 mg/kg)/saline was alternately given in the proximal/distal jejunum.
  
  
  RESULTS
  Part I: There was no clinically or statistically significant difference between systemic atropine and saline solution on the degree of jejunal mucosal eversion after resection. Part II: There was a statistically significant decrease in jejunal mucosal eversion with atropine compared with saline solution when injected into a local jejunal artery.
  
  
  CONCLUSIONS
  Systemic atropine (0.04 mg/kg) does not alter the degree of jejunal mucosal eversion during resection and anastomosis. Jejunal intraarterial atropine (0.04 mg/kg) reduced jejunal mucosal eversion during resection and anastomosis.
  
  
  CONCLUSIONS
  The clinical usefulness and consequences of jejunal arterial atropine administration to reduce mucosal eversion remain to be determined.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
authors.forename: Marta
authors.initials: M
authors.lastname: Agrodnia
authors.forename: Joe
authors.initials: J
authors.lastname: Hauptman
authors.forename: Richard
authors.initials: R
authors.lastname: Walshaw
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods / Q000662:veterinary*; D000818:Animals; D001158:Arteries; D001285:Atropine / Q000008:administration & dosage*; D004285:Dogs / Q000601:surgery*; D004334:Drug Administration Schedule; D005260:Female; D007267:Injections / Q000662:veterinary; D007413:Intestinal Mucosa / Q000473:pathology*; D007583:Jejunum / Q000473:pathology / Q000601:surgery*; D018727:Muscarinic Antagonists / Q000008:administration & dosage*; D011446:Prospective Studies; D016037:Single-Blind Method; D013536:Suture Techniques / Q000662:veterinary; D016896:Treatment Outcome
chemical_list: D018727:Muscarinic Antagonists; D001285:Atropine