title: Role of nitric oxide in lipopolysaccharide-induced release of vasopressin in rats.
abstract: This study evaluated the role of nitric oxide (NO) in vasopressin (AVP) release induced by intravenous lipopolysaccharide (LPS) in rats previously treated with intracerebroventricular (i.c.v.) saline, L-NAME, L-arginine or sodium nitroprusside (SNP). In control rats given i.c.v. saline, L-NAME, L-arginine or SNP, AVP levels did not change from baseline. After LPS, plasma AVP increased, reaching a peak at 60 min, and returning to basal levels 4 h later in all i.c.v. pre-treated groups (P<0.05). The LPS administration in rats previously treated with L-NAME induced higher AVP levels (P<0.05) that remained elevated throughout the period of the experiment (P<0.05). These findings confirm the inhibitory role of NO in AVP secretion induced by LPS.
authors.affiliation: Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, São Paulo, Brazil.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Giusti-Paiva
authors.forename: Silvia Graciela
authors.initials: SG
authors.lastname: Ruginsk
authors.forename: Margaret
authors.initials: M
authors.lastname: de Castro
authors.forename: Lucila Leiko Kagohara
authors.initials: LL
authors.lastname: Elias
authors.forename: Evelin Capellari
authors.initials: EC
authors.lastname: Carnio
authors.forename: José
authors.initials: J
authors.lastname: Antunes-Rodrigues
mesh_terms: D000818:Animals; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D014667:Vasopressins / Q000378:metabolism*
chemical_list: D008070:Lipopolysaccharides; D014667:Vasopressins; D009569:Nitric Oxide; D019331:NG-Nitroarginine Methyl Ester