title: The FADD is going nuclear.
abstract: Fas-associated death domain protein (FADD) is an adaptor molecule that bridges the interactions between membrane death receptors and initiator caspases. Thus, the site of its action has always been expected to be the cytoplasmic death-inducing signaling complex (DISC). Recent evidence indicates that FADD primarily resides in the nucleus and appears to shuttle between nucleus and cytoplasm. In addition to its well-established role in transduction of apoptotic signals, FADD may also play a role in regulating genome surveillance and perhaps in other as yet unidentified cellular processes.
authors.affiliation: Department of Pharmacology, SUNY Upstate Medical University, Syracuse, New York 13210, USA. sheikhm@mail.upstate.edu
authors.forename: M Saeed
authors.initials: MS
authors.lastname: Sheikh
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D000818:Animals; D029681:Arabidopsis Proteins / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D020169:Caspases / Q000378:metabolism; D016923:Cell Death / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism*; D053418:Death Domain Receptor Signaling Adaptor Proteins; D004706:Endodeoxyribonucleases / Q000378:metabolism; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D006801:Humans; D017434:Protein Structure, Tertiary; D014407:Tumor Cells, Cultured
chemical_list: D029681:Arabidopsis Proteins; D002352:Carrier Proteins; D053418:Death Domain Receptor Signaling Adaptor Proteins; C485896:PIDD1 protein, human; D044943:Fatty Acid Desaturases; C084083:Fad7 protein, Arabidopsis; D004706:Endodeoxyribonucleases; C118712:MBD4 protein, human; C492249:Mbd4 protein, mouse; D020169:Caspases