title: Familial clustering of dendriform pulmonary ossification.
abstract: Dendriform pulmonary ossification is an extremely rare disease, which is usually found and analysed postmortem. Pathogenesis of pulmonary ossification is therefore still unknown. We describe two males in the same family (a 29 year-old patients and his 58 year-old father) with pulmonary ossification. The young male was symptomatic pneumothorax but his father had been asymptomatic since youth. Familial clustering of pulmonary ossifications strongly suggests a genetic predisposition for the pathogenesis. This is the first report of two cases of dendriform pulmonary ossification in the same family.
authors.affiliation: Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan. a-azuma@nms.ac.jp
authors.forename: Arata
authors.initials: A
authors.lastname: Azuma
authors.forename: Haruko
authors.initials: H
authors.lastname: Miyamoto
authors.forename: Tatsuji
authors.initials: T
authors.lastname: Enomoto
authors.forename: Jiro
authors.initials: J
authors.lastname: Usuki
authors.forename: Shoji
authors.initials: S
authors.lastname: Kudoh
mesh_terms: D000328:Adult; D020022:Genetic Predisposition to Disease; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D011030:Pneumothorax / Q000209:etiology; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed