title: Consanguinity in the Bishopric of Ourense (Galicia, Spain) from 1900 to 1979.
abstract: BACKGROUND
  Knowledge of the levels of inbreeding in the human population is interesting because it is one of the characteristics that conditions its genetic structure and has important genetic-medical repercussions in the descendants of marriages between close relatives. Galicia (north-west Spain) is a region with very special geographic, historic and social characteristics that makes it particularly interesting for consanguinity studies.
  
  
  OBJECTIVE
  The object of this investigation is the study of the levels of inbreeding and the structure of consanguinity in rural area of the Dioceses of Ourense (Galicia) during the period 1900-1979.
  
  
  METHODS
  In the study, data corresponding to 437 parishes, integrated in 80 municipalities of the rural area of the Dioceses of Ourense were analysed. In the period studied, of a total of 110 128 marriages, 9010 took place between biologically related individuals up to the level of second cousins. The rate of consanguinity and the average coefficient of inbreeding of the population, as well as the percentage of the different types of consanguineous marriages, were calculated.
  
  
  RESULTS
  The rate of consanguinity for the period 1900-1979 is 8.18% and the average coefficient of inbreeding is 3.0662 x 10(-3). The most frequent type of consanguineous marriage is between second cousins (4.00% of all marriages). There is a notably high frequency of marriages of multiple relationships (0.52%) and the frequency of uncle-niece or aunt-nephew marriages is 0.16%. The average value of the M22/M33 ratio is 0.66 and during the 80 years studied, with regard to the temporal variation of the average coefficient of inbreeding, the annual values followed a polynomial curve with an inflection point in 1921.
  
  
  CONCLUSIONS
  The highest values of consanguinity detected in Galicia, for the same period, were registered in the Dioceses of Ourense and the high rate of uncle-niece or aunt-nephew marriages habitual in this region was confirmed. The latter is explained by the important incidence in the Galician population of the migration to America at the end of the 19th and beginning of the 20th century. However, when the relative frequency of this type of marriage with respect to the total number of consanguineous marriages is calculated, it has relatively low values due to the high proportion of marriages between second cousins and marriages of multiple relationships, the highest in Galicia for an equal period of time. The rate of marriages between first cousins is also the highest in Galicia, confirming a phenomenon that appears to be common in the rural areas of the northern area of the Iberian Peninsula.
authors.affiliation: Laboratory of Anthropology, Faculty of Biology, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain. tavarela@usc.es
authors.forename: T A
authors.initials: TA
authors.lastname: Varela
authors.forename: R L
authors.initials: RL
authors.lastname: Aínsua
authors.forename: J
authors.initials: J
authors.lastname: Fariña
mesh_terms: D003241:Consanguinity; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008393:Marriage / Q000208:ethnology / Q000706:statistics & numerical data*; D011156:Population Density; D012042:Registries; D012424:Rural Population / Q000706:statistics & numerical data*; D013030:Spain / Q000453:epidemiology