[The use of large doses of retabolil and support loads for prevention of osteopenia in male rats during suspension].
The histological and histomorphometric techniques were used to evaluate effects of anabolic steroid rhetabolil and graded support loads on the osteopenia progress in suspended rats. Thirty-day head-down tail suspension was found to inhibit body mass gain, induce a moderate stress reaction, dampen the longitudinal bone growth and provoke osteopenia in the spongy metaphysis of rats' tibiae. Rhetabolil injection at a total dose of 10 mg per 100 g of the body mass (a large dose) prevented tibial osteopenia, and yet it hampered bone growth in length. Daily 3-hr. support loads also inhibited osteopenia in the suspended rats, especially when combined with the rhetabolil injections. The unfavorable side-effect of the dose was virtually complete thymus aplasia in all animals. Hence, large rhetabolil doses as a means against osteopenia in the inadequately loaded locomotor system should be given with great care and require further investigations.
Durnova
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D045930:Anabolic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D001851:Bone Diseases, Metabolic / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D019417:Hindlimb Suspension / Q000009:adverse effects; D008206:Lymphatic Diseases / Q000139:chemically induced; D008297:Male; D009277:Nandrolone / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D000077603:Nandrolone Decanoate; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects; D016474:Weight-Bearing / Q000502:physiology*
D045930:Anabolic Agents; D009277:Nandrolone; D000077603:Nandrolone Decanoate