title: Effect of supplemental pre-operative fluid on postoperative nausea and vomiting.
abstract: In a prospective, double-blind, randomised controlled trial, we studied the effects of pre-operative fluid load on post-operative nausea and vomiting. Eighty patients attending for laparoscopic cholecystectomy or gynaecological surgery were randomly allocated to receive 2 ml.kg-1 (conservative) or 15 ml.kg-1 (supplemental) Hartmann's solution intravenously, shortly before induction of anaesthesia. During the operation, fluid management was identical in both groups. During the first post-operative 24 h, post-operative nausea and vomiting occurred in 29 patients (73%) in the conservative fluid group and nine patients (23%) in the supplemental fluid group (p = 0.01). Supplemental pre-operative fluid is an inexpensive and safe therapy for reducing post-operative nausea and vomiting.
authors.affiliation: Division of Critical Care Medicine, Department of Anaesthesiology, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8054, St. Louis, MO 63110, USA.
authors.forename: S Z
authors.initials: SZ
authors.lastname: Ali
authors.forename: A
authors.initials: A
authors.lastname: Taguchi
authors.forename: B
authors.initials: B
authors.lastname: Holtmann
authors.forename: A
authors.initials: A
authors.lastname: Kurz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017081:Cholecystectomy, Laparoscopic; D004311:Double-Blind Method; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007552:Isotonic Solutions / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D000077325:Ringer's Lactate
chemical_list: D007552:Isotonic Solutions; D000077325:Ringer's Lactate