[Molecular-biological markers as prognostic factors in breast cancer of I-IIA stage].
The study of molecular-biological markers for prediction of recurrence-free survival in breast cancer stage I-IIA demonstrates that high expression of thymidilate synthetase and high maximal density of microvessels are prognostically effective and that the prognosis is influenced by expression of both Bcl-2 and Bax. Low recurrence-free survival was observed in Bcl-2-/Bax patients (31%, median 44 months) while such survival was high in Bcl-2+/Bax patients (86%, median was not reached). The findings can be used for prognostication of a breast cancer clinical course.
Stepanova
E V
EV
N. N. Blokhin Russian Cancer Research Center, 115478, Moscow.
Zagrekova
E I
EI
Ermilova
V D
VD
Turbin
A D
AD
Petrovichev
N N
NN
Vysotskaia
I V
IV
Dbar
Zh N
ZhN
Pashchenko
N V
NV
Baryshnikov
A Iu
AIu
Lichinitser
M R
MR
D000230:Adenocarcinoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D001943:Breast Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D018275:Carcinoma, Lobular / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D011518:Proto-Oncogene Proteins