Novel hemoglobin variant [beta66(E10) Lys-->Asn], with decreased oxygen affinity, causes falsely low hemoglobin A1c values by HPLC.
Friess
Ulrich
U
Department of Medicine IV (Endocrinology, Metabolism, and Clinical Chemistry), University of Tuebingen, Otfried-Mueller-Strasse 10, D-72076 Tuebingen, Germany. ulrich.friess@med.uni-tuebingen.de
Beck
Alexander
A
Kohne
Elisabeth
E
Lehmann
Rainer
R
Koch
Sylvia
S
Haring
Hans-Ulrich
HU
Schmuelling
Reinhold-Michael
RM
Schleicher
Erwin
E
D000368:Aged; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000209:etiology; D005188:False Negative Reactions; D042882:Gallstones / Q000150:complications; D006442:Glycated Hemoglobin / Q000032:analysis*; D006454:Hemoglobins / Q000032:analysis* / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D007118:Immunoassay; D008297:Male; D008969:Molecular Sequence Data; D010100:Oxygen / Q000737:chemistry*; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications
D006442:Glycated Hemoglobin; D006454:Hemoglobins; D010100:Oxygen