The chronological life span of Saccharomyces cerevisiae.
Simple model systems have played an important role in the discovery of fundamental mechanisms of aging. Studies in yeast, worms and fruit flies have resulted in the identification of proteins and signalling pathways that regulate stress resistance and longevity. New findings indicate that these pathways may have evolved to prevent damage and postpone aging during periods of starvation and may be conserved from yeast to mammals. We will review the yeast S. cerevisiae model system with emphasis on the chronological life span as a model system to study aging and the regulation of stress resistance in eukaryotes.
Fabrizio
Paola
P
Andrus Gerontology Center, Division of Biogerontology and Department of Biological Sciences, University of Southern California, Los Angeles 90089-0191, USA.
Longo
Valter D
VD
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology; D003470:Culture Media; D004734:Energy Metabolism; D005800:Genes, Fungal; D006801:Humans; D008322:Mammals / Q000502:physiology; D018384:Oxidative Stress; D012100:Reproduction, Asexual; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology; D013045:Species Specificity; D013482:Superoxide Dismutase / Q000235:genetics / Q000502:physiology; D000072105:Superoxide Dismutase-1; D013997:Time Factors; D000099156:Superoxide Dismutase 2
D003470:Culture Media; D029701:Saccharomyces cerevisiae Proteins; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1; D000099156:Superoxide Dismutase 2; C000606290:SOD1 protein, human