The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts.
In a multi-ethnic cohort we analyzed the Saitohin (STH) gene 'Q7R' polymorphism in 200 late-onset Alzheimer's disease cases (LOAD), 60 Parkinson's disease cases with dementia (PDD), 84 Parkinson's disease cases without dementia and 458 controls. We found no significant differences in genotype or allele frequencies when LOAD or PD cases were compared to controls. Ethnic differences in STH genotype frequencies for cases and controls were observed and these were statistically significant (cases n=344, P<0.03; controls n=458, P<0.001). We also observed a trend in non-Hispanic white PDD cases with the STH 'QQ' (Tau H1/H1) genotype increased (76%) compared to PD cases without dementia (61.7%) and controls (56.6%); however, this difference was not statistically significant (PDD vs. controls OR 2.1; 95% CI: 0.8-5.8, P=0.2).
Clark
Lorraine N
LN
Department of Pathology, Columbia University, New York, NY, USA. lc654@columbia.edu
Levy
Gilberto
G
Tang
Ming-Xin
MX
Mejia-Santana
Helen
H
Ciappa
Alejandra
A
Tycko
Benjamin
B
Cote
Lucien J
LJ
Louis
Elan D
ED
Mayeux
Richard
R
Marder
Karen
K
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000208:ethnology / Q000235:genetics*; D044383:Black People / Q000235:genetics; D005260:Female; D006239:Haplotypes; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics; D016875:tau Proteins / Q000235:genetics*; D001741:Black or African American
C458340:STH protein, human; D016875:tau Proteins