Cybernetic modeling of the cephalosporin C fermentation process by Cephalosporium acremonium.
A cybernetic mathematical model has been developed to describe the production of cephalosporin C. In developing the model, diauxic behavior of substrate consumption, morphological differentiation of cells, and catabolite repression of cephalosporin C production by the preferred substrate, glucose, were considered. The proposed model was tested on the experimental data from the literature and could adequately describe the morphological differentiation of cells, the sequential utilization of carbon sources and the production of cephalosporin C. It could be a useful tool to optimize the production of cephalosporin C by Cephalosporium acremonium in batch, fed-batch or continuous operations.
Kim
Byung Min
BM
Department of Chemical and Biological Engineering, Korea University, Anam-dong, Seongbuk-ku, Seoul 136-701, Korea.
Kim
Seung Wook
SW
Yang
Dae Ryook
DR
D000164:Acremonium / Q000254:growth & development* / Q000378:metabolism*; D019149:Bioreactors / Q000382:microbiology; D002455:Cell Division / Q000502:physiology; D002511:Cephalosporins / Q000096:biosynthesis*; D003198:Computer Simulation; D005285:Fermentation / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D008954:Models, Biological; D012680:Sensitivity and Specificity; D013395:Sucrose / Q000378:metabolism
D002511:Cephalosporins; C025163:cephalosporin C; D013395:Sucrose; D005947:Glucose