title: Combination therapy with caspofungin and liposomal amphotericin B for invasive aspergillosis.
abstract: Ina 24-month-old girl with acute lymphoblastic leukemia and invasive aspergillosis, only combination therapy with liposomal amphotericin B and caspofungin achieved a good response. Combination therapy could be a useful treatment option in children with invasive fungal disease, but before it can be routinely recommended, carefully controlled in vivo studies and well-designed randomized clinical trials are needed.
authors.affiliation: Department of Pediatric Hematology, Children's Hospital III, Frankfurt, Germany.
authors.forename: Ziju
authors.initials: Z
authors.lastname: Elanjikal
authors.forename: Jan
authors.initials: J
authors.lastname: Sörensen
authors.forename: Helga
authors.initials: H
authors.lastname: Schmidt
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Dupuis
authors.forename: Kathrin
authors.initials: K
authors.lastname: Tintelnot
authors.forename: Günter
authors.initials: G
authors.lastname: Jautzke
authors.forename: Thomas
authors.initials: T
authors.lastname: Klingebiel
authors.forename: Thomas
authors.initials: T
authors.lastname: Lehrnbecher
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy*; D000077336:Caspofungin; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D054714:Echinocandins; D005260:Female; D005500:Follow-Up Studies; D016469:Fungemia / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D055666:Lipopeptides; D008081:Liposomes; D009894:Opportunistic Infections / Q000188:drug therapy* / Q000276:immunology; D010455:Peptides; D010456:Peptides, Cyclic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000276:immunology; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D054714:Echinocandins; D055666:Lipopeptides; D008081:Liposomes; D010455:Peptides; D010456:Peptides, Cyclic; D000666:Amphotericin B; D000077336:Caspofungin