Adolescent rats discriminate a mild state of ethanol intoxication likely to act as an appetitive unconditioned stimulus.
Practically no information is available in relation to the capability of the adolescent animal in terms of discriminating postabsorptive effects of ethanol. Three experiments were conducted to analyze whether young, genetically heterogeneous rats discriminate different stages of the process of intoxication exerted by a low dose (0.5 g/kg) of ethanol. An ethanol pharmacokinetic profile was first examined to select two stages within the process of ethanol intoxication that, as a function of the corresponding blood ethanol concentrations (BECs), could represent two potentially discriminable drug states. In a second experiment, sucrose was available when the BECs of rats peaked or were of a lesser magnitude (5 and 30 min postadministration time, respectively). When animals were tested under similar or different drug states relative to the training procedure, no behavioral evidence indicative of differential sucrose expectancy was obtained. In Experiment 3, rats discriminated each of the previously defined ethanol states from a non-drug state. Unexpectedly, it was also found that the pharmacological effects of the 0.5-g/kg dose of ethanol are likely to support appetitive associative learning that involves the taste of sucrose as a conditioned stimulus. The apparent positive affective components of the state of ethanol intoxication have rarely been observed in genetically heterogeneous rats with rather brief experiences with the drug's effects.
Fernández-Vidal
Juan M
JM
Instituto de Investigación Médica M. y M. Ferreyra, Córdoba, C.P. 5000, Argentina. molina3@immf.uncor.edu
Spear
Norman E
NE
Molina
Juan Carlos
JC
D000435:Alcoholic Intoxication / Q000523:psychology*; D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001835:Body Weight / Q000502:physiology; D002492:Central Nervous System Depressants / Q000097:blood / Q000493:pharmacokinetics; D002849:Chromatography, Gas; D003216:Conditioning, Operant / Q000187:drug effects*; D004192:Discrimination, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics; D007262:Infusions, Intravenous; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013395:Sucrose / Q000494:pharmacology; D013549:Sweetening Agents / Q000494:pharmacology
D002492:Central Nervous System Depressants; D013549:Sweetening Agents; D000431:Ethanol; D013395:Sucrose