title: Effect of kainate on the synaptic transmission in hippocampal CA1 region.
abstract: OBJECTIVE
  To investigate the effect of activated kainate receptor on both the excitatory and inhibitory synaptic transmission in the neurons in the hippocampal CA1 region.
  
  
  METHODS
  Blind whole-cell voltage-clamp recordings were performed on the CA1 pyramidal cells in adult rat hippocampal slices to examine and analyze the effect of bath-applied kainate (10 micromol/L) on CA1 afferent fiber-evoked excitatory postsynaptic currents (EPSCs) and inhibitory postsynaptic currents (IPSCs), respectively.
  
  
  RESULTS
  Activation of kainate receptor significantly depressed both IPSCs (P <0.01) and EPSCs (P <0.01) in neurons in the hippocampus CA1 region.
  
  
  CONCLUSIONS
  Activation of kainate receptors directly inhibit excitatory and inhibitory input in those neurons, which contributes to the development of epilepsy in the hippocampus by affecting the dynamic balance of the hippocampal neurons.
authors.affiliation: Institute of Neuroscience of PLA, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. zl-liu@163.net
authors.forename: Zhi-liang
authors.initials: ZL
authors.lastname: Liu
authors.forename: Ru-xiang
authors.initials: RX
authors.lastname: Xu
authors.forename: Xiao-dan
authors.initials: XD
authors.lastname: Jiang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yin
authors.forename: Cheng-yi
authors.initials: CY
authors.lastname: Luo
authors.forename: Mou-xuan
authors.initials: MX
authors.lastname: Du
authors.forename: Yu-xi
authors.initials: YX
authors.lastname: Zou
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007608:Kainic Acid / Q000494:pharmacology*; D009433:Neural Inhibition / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D018092:Kainic Acid Receptors / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D007608:Kainic Acid; D018092:Kainic Acid Receptors