[Molecular pathogenesis of carcinoma of the esophagus].
Carcinoma of the esophagus is present in two distinct morphological cell types: squamous or pavimentous cell carcinoma and adenocarcinoma. In this article, the main genetic alterations found in both types of carcinomas and their implications are described. The sequence of these alterations is related to histogenesis, making it possible to understand tumor progression from normal epithelium to invasive carcinoma. A comparison is attempted between the molecular development of esophagus carcinomas and that of colorectal carcinoma.
Giménez
Alejandra M
AM
Departmento de Patología, Instituto de Estudios Oncológicos Fundación Maissa, Academia Nacional de Medicina, Buenos Aires.
Copelli
Silvia B
SB
Speroni
Alfredo H
AH
Meiss
Roberto P
RP
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000235:genetics / Q000473:pathology; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D016147:Genes, Tumor Suppressor / Q000502:physiology; D006801:Humans