1,2,4-Triazolo mercapto and aminonitriles as potent antifungal agents.
A series of 3-mercapto-1,2,4-triazoles mono or disubstituted at 2-, 3- or 4-positions were synthesized and evaluated as antifungal agents. Many of these derivatives exhibit high activity against Candida albicans and Candida tropicalis.
Collin
Xavier
X
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, avenue du Pr Léon Bernard, F-35043 Rennes Cedex, France. xavier.collin@univ-rennes1.fr
Sauleau
Armelle
A
Coulon
Joël
J
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D041022:Candida tropicalis / Q000187:drug effects*; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D009570:Nitriles / Q000138:chemical synthesis* / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000935:Antifungal Agents; D007202:Indicators and Reagents; D009570:Nitriles; D014230:Triazoles