title: Cooperative omega loops in cytochrome c: role in folding and function.
abstract: Hydrogen exchange experiments under slow exchange conditions show that an omega loop in cytochrome c (residues 40-57) acts as a cooperative unfolding/refolding unit under native conditions. This unit behavior accounts for an initial step on the unfolding pathway, a final step in refolding, and a number of other structural, functional and evolutionary properties.
authors.affiliation: Department of Biochemistry and Biophysics, Johnson Research Foundation, University of Pennsylvania School of Medicine, 422 Curie Blvd, 1007 Stellar Chance Bldg, Philadelphia, PA 19104-6059, USA. mmg@hx2.med.upenn.edu
authors.forename: Mallela M G
authors.initials: MM
authors.lastname: Krishna
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.forename: Jon N
authors.initials: JN
authors.lastname: Rumbley
authors.forename: S Walter
authors.initials: SW
authors.lastname: Englander
mesh_terms: D003574:Cytochrome c Group / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D009154:Mutation; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D013816:Thermodynamics
chemical_list: D003574:Cytochrome c Group; D006859:Hydrogen