title: Single hospital experience of TRALI.
abstract: BACKGROUND
  TRALI is a serious adverse effect of blood transfusion. There is evidence that the condition is underrecognized and underreported.
  
  
  METHODS
  This study was an observational study carried out in a single hospital.
  
  
  RESULTS
  Eleven cases of TRALI were recognized over 12 years. In 10 cases the implicated donor unit was FFP and in 1 case uncertain. All implicated donors were parous women. In 4 cases the presumed causative antibodies were to an HLA class II antigen only. Specific anti-neutrophil antibodies, possibly causative, were detected in 1 case only. Ten of the 11 cases required mechanical ventilatory support. Five persons died as a result of the TRALI. The observed incidence of TRALI caused by FFP is 1 in 7900 units transfused.
  
  
  CONCLUSIONS
  TRALI is the most common serious adverse effect of blood transfusion in our hospital. Antibodies to HLA class II antigens should be looked for routinely when investigating a possible case of TRALI.
authors.affiliation: Department of Hematology, Freeman Hospital, and the National Blood Service, Newcastle upon Tyne, UK. jonathan.walls@tfh.nuth.northy.nhs.uk
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Wallis
authors.forename: Anatole
authors.initials: A
authors.lastname: Lubenko
authors.forename: Angus W
authors.initials: AW
authors.lastname: Wells
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Chapman
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis; D016913:Blood Component Transfusion; D001782:Blood Donors; D001793:Blood Preservation; D002675:Child, Preschool; D015925:Cryopreservation; D005260:Female; D006761:Hospitals / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D007958:Leukocyte Count; D008171:Lung Diseases / Q000097:blood / Q000453:epidemiology* / Q000209:etiology* / Q000276:immunology; D008297:Male; D009504:Neutrophils / Q000473:pathology; D012709:Serum Albumin / Q000032:analysis; D065227:Transfusion Reaction
chemical_list: D000906:Antibodies; D012709:Serum Albumin