[Replication of animal model and pathological study of delayed multiple organ dysfunction syndrome in mice].
OBJECTIVE
To replicate a model of delayed multiple organ dysfunction syndrome (MODS) in mice.


METHODS
Kunming mice of 6-8 week age were randomly divided into normal control group and experimental group. They were sacrificed on days 0 to 2, days 3 to 7, days 8 to 12. Symptoms and signs, survival rate, organ function parameters and pathological changes in main organs were observed in mice of all groups.


RESULTS
Eight days after zymosan administration, animals showed MODS-like changes. Plasma level of alanine aminotransferase(ALT), blood urea nitrogen(BUN) and creatinine(Cr) were increased and severe pathological lesions were observed in tissues of the lung, liver, heart, kidney and gut, etc.


CONCLUSIONS
A delayed model of MODS is replicated in mice by intraperitoneal injection of zymosan.
Sun
Yu
Y
304th Hospital of People's Liberation Army, Beijing 100037, China.
Lu
Jiang-yang
JY
Wang
Xiao-hong
XH
Hu
Sen
S
Yang
Yi
Y
Tong
Xin
X
D000818:Animals; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009102:Multiple Organ Failure / Q000473:pathology; D015054:Zymosan
D015054:Zymosan