Synthesis of a novel crown ether derived from chiro-inositol and its catalytic activity on the asymmetric Michael addition.
A novel 18-membered chiral crown ether was prepared in four steps starting from L-quebrachitol, a chiro-inositol, and its catalytic activity in the Michael addition reaction of glycine imine with several Michael acceptors was studied.
Akiyama
Takahiko
T
Department of Chemistry, Gakushuin University, 1-5-1, Mejiro, Toshima-ku, Tokyo 171-8588, Japan. takahiko.akiyama@gakushuin.ac.jp
Hara
Mikiko
M
Fuchibe
Kohei
K
Sakamoto
Shigeru
S
Yamaguchi
Kentaro
K
D002384:Catalysis; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000378:metabolism; D007294:Inositol / Q000138:chemical synthesis* / Q000378:metabolism; D015394:Molecular Structure; D009904:Optical Rotation
D004988:Ethers, Cyclic; D007294:Inositol