[Hemodynamic factors].
It is well-known that hypertension often coexists with diabetes. Based on previous reports, it appears that insulin resistance is promoted by hypertension and that hypertension is promoted by insulin resistance. In this review, we discuss hemodynamic factors underlying insulin resistance and hypertension. In addition, the insulin resistance seen in three hypertensive rat models (the high salt-fed Sprague-Dawley rat, the Dahl salt-sensitive rat and the chronically angiotensin II-infused rat) are presented. The findings presented suggest the importance of developing new therapeutic approaches (e.g., potassium supplementation and anti-oxidant administration) to the management of insulin resistance and hypertension.
Ogihara
Takehide
T
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo.
Asano
Tomoichiro
T
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D003920:Diabetes Mellitus / Q000209:etiology*; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007328:Insulin / Q000502:physiology; D007333:Insulin Resistance; D018384:Oxidative Stress; D051381:Rats; D020303:Rats, Inbred Dahl; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction
D007328:Insulin; D000804:Angiotensin II