Reduction of infarction volume by bolus injection of pamiteplase, a modified tissue plasminogen activator with a longer half-life.
Using a rat model of thromboembolic stroke we evaluated whether or not fibrinolysis by bolus injection of pamiteplase, a modified tissue plasminogen activator (tPA) with a longer half-life, reduces infarction volume. Infarction volume was significantly reduced by the early administration of pamiteplase at 2 h after the onset of ischemia. Hemorrhagic infarction was observed only in 3 of 10 rats (30%) treated at 6 h. Thus, bolus injection of pamiteplase can reduce infarction volume suppressing the incidence of hemorrhage.
Suzuki
Yasuyuki
Y
Department of Neurological Surgery, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo 173-8610, Japan.
Kano
Tsuneo
T
Katayama
Yoichi
Y
Tejima
Emiri
E
Harada
Tadashi
T
D000208:Acute Disease; D000818:Animals; D002543:Cerebral Hemorrhage / Q000517:prevention & control; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000628:therapy*; D004195:Disease Models, Animal; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology*; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000494:pharmacology*
D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator; C085027:pamiteplase