A patient with primary biliary cirrhosis complicated with slowly progressive insulin-dependent diabetes mellitus.
We report a case of primary biliary cirrhosis (PBC) complicated by slowly progressive insulin-dependent diabetes mellitus (SPIDDM). A 67-year-old woman was diagnosed as having PBC based on clinical manifestations and a positive result of anti-mitochondrial antibody. Furthermore, SPIDDM was diagnosed by her clinical course and a positive result of anti-glutamic acid decarboxylase antibody. Both PBC and SPIDDM are considered to be autoimmune diseases. However, the coexistence of PBC and SPIDDM is extremely rare. Liver cirrhosis sometimes accompanies hyperglycemia. When the etiology of liver cirrhosis is an autoimmune disorder such as PBC, SPIDDM should be considered as a cause of hyperglycemia.
Nakasone
Hiroki
H
Okinawa Kenritsu Hokubu Hospital, Okinawa.
Kinjo
Kazushi
K
Yamashiro
Masaaki
M
Kamiyama
Tsukasa
T
Kamiyama
Sakiko
S
Miyazato
Hitoshi
H
Matsushita
Tatsuhiko
T
Arakawa
Yukihiro
Y
Ohshiro
Takeharu
T
Toma
Shiyu
S
Chinen
Kiyoharu
K
Yamashiro
Masato
M
Miyagi
Masatake
M
Makishi
Tomoko
T
Hokama
Akira
A
Sakugawa
Hiroshi
H
Kinjo
Fukunori
F
Saito
Atsushi
A
D000368:Aged; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000032:analysis; D003131:Combined Modality Therapy; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D004032:Diet; D018450:Disease Progression; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007564:Japan; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D008111:Liver Function Tests; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D001786:Blood Glucose; D007328:Insulin