Successful use of somatostatin in a case of neonatal chylothorax.
A 2-week-old infant status postrepair of gastroschisis had spontaneous bilateral chylothoraces necessitating thoracostomy drainage. Voluminous chylous drainage persisted despite cessation of enteral feedings. On administration of the somatostatin analogue octreotide, pleural drainage diminished markedly and ceased entirely within 4 days. These results, along with reported successes in treatment of chylothorax after thoracic surgery, support the prospective investigation of somatostatin use in problematic chylothorax.
Au
Macy
M
Division of Pediatric Surgery, Saint Louis University School of Medicine, St Louis, MO 63104, USA.
Weber
Thomas R
TR
Fleming
Robert E
RE
D002916:Chylothorax / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D020139:Gastroschisis / Q000601:surgery; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D015282:Octreotide / Q000627:therapeutic use*; D011183:Postoperative Complications; D019616:Thoracic Surgical Procedures / Q000009:adverse effects; D013907:Thoracostomy
D006728:Hormones; D015282:Octreotide