Biological role of p300 in cardiac myocytes.
A cellular target of adenovirus E1A oncoprotein, p300 is a transcriptional coactivator required for the maintenance of differentiated phenotypes in cardiac myocytes. The full transcriptional activities of hypertrophy-responsive transcription factors such as GATA-4 and MEF2 require interaction with p300. A p300 protein also possesses intrinsic histone acetyl transferase activity, which promotes a transcriptionally active chromatin configuration. Here, we review the biological functions of p300 in cardiac myocytes. Although p300 is biologically active in many cell types, this protein appears to play a crucial role in the differentiation, growth and apoptosis of cardiac myocytes. Understanding precise mechanisms of its biological functions will shed light on molecular pathways for heart failure.
Yanazume
Tetsuhiko
T
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Shogoin, Sakyo-ku, Kyoto, Japan.
Morimoto
Tatsuya
T
Wada
Hiromichi
H
Kawamura
Teruhisa
T
Hasegawa
Koji
K
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism*; D009687:Nuclear Proteins / Q000502:physiology*; D010641:Phenotype; D011485:Protein Binding; D015534:Trans-Activators / Q000502:physiology*; D014158:Transcription, Genetic
D009687:Nuclear Proteins; D015534:Trans-Activators