title: Poor functional recovery may indicate restenosis in patients after coronary angioplasty.
abstract: OBJECTIVE
  To investigate whether poor response to exercise training can detect restenosis in asymptomatic patients after percutaneous transluminal coronary angioplasty (PTCA).
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  A hospital-based outpatient cardiac rehabilitation program in Taiwan.
  
  
  METHODS
  Sixteen patients aged 49.7+/-7.8 years who had undergone PTCA and completed a 3-month exercise program. Patients were separated into a restenosis group (n=7; age, 46.4+/-9.8y) and a nonrestenosis group (n=9; age, 52.3+/-12.9y), according to their angiography follow-up results. The interval between PTCA and angiography ranged from 6 months to 2 years.
  
  
  METHODS
  Bicycle exercise workouts were conducted 3 times a week during rehabilitation, with exercise intensity adjusted to each patient's ventilatory threshold.
  
  
  METHODS
  A graded exercise test with gas analysis was conducted before training, at 6 weeks and at 3 months after training, to evaluate the sequential changes of cardiorespiratory function.
  
  
  RESULTS
  After 3 months of training, the nonrestenosis group showed an increase of 30.4% in peak oxygen uptake (Vo(2)peak, P<.05), 13.7% in peak oxygen pulse (P<.05), 22.2% in peak rate-pressure product (P<.05), and 13.6% in peak work rate (P<.05). Most of the improvement occurred within the first 6 weeks of training. The restenosis group did not show significant increase in these variables. At the ventilatory threshold, the nonrestenosis group also displayed a significant increase of Vdot;o(2), oxygen pulse, and work rate. However, the restenosis group showed no improvement after training.
  
  
  CONCLUSIONS
  Functional recovery appears to be a good indicator of restenosis for patients after PTCA. A poor response to exercise can be noted within 6 weeks of training in PTCA patients with restenosis.
authors.affiliation: Departments of Physical Medicine and Rehabilitation, National Tiwan Unviersity Hospital, Taipei, Taiwan. chinglan@seed.net.tw
authors.forename: Ching
authors.initials: C
authors.lastname: Lan
authors.forename: Ssu-Yuan
authors.initials: SY
authors.lastname: Chen
authors.forename: Shu-Fen
authors.initials: SF
authors.lastname: Chiu
authors.forename: Chen-Jung
authors.initials: CJ
authors.lastname: Hsu
authors.forename: Jin-Shin
authors.initials: JS
authors.lastname: Lai
authors.forename: Pei-Liang
authors.initials: PL
authors.lastname: Kuan
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000534:rehabilitation*; D001944:Breath Tests; D016022:Case-Control Studies; D017023:Coronary Angiography; D003327:Coronary Disease / Q000378:metabolism / Q000503:physiopathology / Q000534:rehabilitation*; D004562:Electrocardiography; D005080:Exercise Test; D005081:Exercise Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010807:Physical Endurance; D020127:Recovery of Function; D012008:Recurrence; D012720:Severity of Illness Index; D013318:Stroke Volume; D013624:Taiwan; D017211:Treatment Failure