Taenia crassiceps cysticercosis in mice does not increase the carcinogenic effect of methyl-nitrosourea.
An association between brain cysticercosis and malignant neoplasms in humans has recently been reported. To explore the possibility of a potentiating effect of cysticercosis on carcinogenesis mice infected with Taenia crassiceps cysticerci were exposed to the carcinogenic substance methyl-nitrosourea; 35% of them developed lymphoma, in contrast with 50% of control non-infected animals exposed to MNU. In this experimental model of cysticercosis we did not find a potentiating effect of peritoneal cysticercosis on the carcinogenicity of MNU.
Ordoñez
Graciela
G
Neuroimmunology Unit, National institute of Neurology and Neurosurgery of Mexico, Insurgentes Sur 3877, Mexico City 14269, Mexico.
Rembao
Daniel
D
Sotelo
Julio
J
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D003551:Cysticercosis / Q000469:parasitology / Q000503:physiopathology*; D003552:Cysticercus / Q000472:pathogenicity; D005260:Female; D015994:Incidence; D008223:Lymphoma / Q000139:chemically induced* / Q000453:epidemiology; D008770:Methylnitrosourea / Q000633:toxicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D010529:Peritoneal Cavity / Q000469:parasitology
D002273:Carcinogens; D008770:Methylnitrosourea