title: Partially parallel three-dimensional magnetic resonance imaging for the assessment of lung perfusion--initial results.
abstract: BACKGROUND
  Contrast-enhanced magnetic resonance imaging (MRI) of lung perfusion requires a high spatial and temporal resolution. Partially parallel MRI offers an improved spatial and temporal resolution.
  
  
  OBJECTIVE
  To assess the feasibility of partially parallel MRI for the assessment of lung perfusion.
  
  
  METHODS
  Two healthy volunteers and 14 patients were examined with a contrast-enhanced 3D gradient-echo pulse sequence with partially parallel image acquisitions (TE/TR/alpha: 0.8/1.9 milliseconds/40 degrees; voxel size 3.6 x 2.0 x 5.0 mm3, TA: 1.5 seconds). The image analysis included an analysis of the signal-to-noise ratio in the lungs in areas with normal and impaired perfusion. 3D MR perfusion image data were analyzed for perfusion defects and compared with radionuclide perfusion scans, which were available for 10 of 14 patients.
  
  
  RESULTS
  The analysis of the 3D perfusion-weighted data allowed a clear differentiation of perfusion abnormalities: MRI showed normal lung perfusion in 9 of 16 cases, whereas perfusion abnormalities were observed in 7 cases. When compared with the radionuclide perfusion scans, a good intermodality agreement was shown (kappa = 0.74). When compared with normally perfused lung a significantly lower signal to noise ratio was observed in hypoperfused lung (7 versus 17; P = 0.02).
  
  
  CONCLUSIONS
  Partially parallel MRI might be used for the assessment of lung perfusion. Future studies are required to further evaluate the diagnostic impact of this technique.
authors.affiliation: Deutsches Krebsforschungszentrum, Innovative Krebsdiagnostik und Therapie, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. c.fink@dkfz.de
authors.forename: Christian
authors.initials: C
authors.lastname: Fink
authors.forename: Michael
authors.initials: M
authors.lastname: Bock
authors.forename: Michael
authors.initials: M
authors.lastname: Puderbach
authors.forename: Astrid
authors.initials: A
authors.lastname: Schmähl
authors.forename: Stefan
authors.initials: S
authors.lastname: Delorme
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000502:physiology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation; D012129:Respiratory Function Tests
chemical_list: D003287:Contrast Media