Pre-mRNA splicing modulations in senescence.
Aging and associated diseases involve multilevel changes in the complex phenomenon of alternative splicing. Here, we review the potential genomic and environmental origins of such changes and discuss the research implications of these findings.
Meshorer
Eran
E
Department of Biological Chemistry, the Institute of Life Sciences, the Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Soreq
Hermona
H
D000375:Aging / Q000235:genetics* / Q000378:metabolism; D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D016922:Cellular Senescence / Q000235:genetics*; D005057:Eukaryotic Cells / Q000378:metabolism*; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009154:Mutation / Q000235:genetics; D019636:Neurodegenerative Diseases / Q000235:genetics; D012322:RNA Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*
D034441:Heterogeneous-Nuclear Ribonucleoproteins; D012322:RNA Precursors; D012333:RNA, Messenger