Evolution of development: beyond bicoid.
The Bicoid-based anterior patterning system of Drosophila embryogenesis appears to be unique to higher dipterans. A new study suggests how this may have evolved out of an alternative mechanism based on cooperating Orthodenticle and Hunchback proteins, the two mechanisms intersecting at the level of downstream target genes.
Lynch
Jeremy
J
Department of Biology, New York University, New York, NY 10003, USA.
Desplan
Claude
C
D000818:Animals; D005075:Biological Evolution; D019521:Body Patterning / Q000502:physiology*; D004330:Drosophila / Q000196:embryology*; D029721:Drosophila Proteins; D005314:Embryonic and Fetal Development / Q000502:physiology*; D018398:Homeodomain Proteins / Q000502:physiology; D008954:Models, Biological; D034622:RNA Interference; D015534:Trans-Activators / Q000502:physiology; D014231:Tribolium / Q000196:embryology*
D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D015534:Trans-Activators; C056478:bcd protein, Drosophila; C093053:oc protein, Drosophila