Total synthesis of (+/-)-spiroxin C.
[reaction: see text] The first total synthesis of a marine-derived potent antitumor antibiotic, (+/-)-spiroxin C, was achieved via a TBAF-activated Suzuki-Miyaura cross-coupling reaction as a key step, which was also shown to be useful for the synthesis of sterically hindered binaphthyl derivatives.
Miyashita
Kazuyuki
K
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Sakai
Takayuki
T
Imanishi
Takeshi
T
D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000903:Antibiotics, Antineoplastic; D009281:Naphthalenes; D013141:Spiro Compounds; C478427:spiroxin C; D010165:Palladium