[Effective treatment with the additional administration of UFT for refractory malignant pleural effusion secondary to adenocarcinoma of the lung after the treatment regimen of gemcitabine and vinorelbine].
The patient was a 71-year-old man with pleural effusion secondary to adenocarcinoma of the lung. Systemic chemotherapy with gemcitabine (GEM) and vinorelbine (VNR) was administered. This treatment brought a decrease in pleural effusion. After three cycles of the regimen with GEM and VNR, the regimen was changed to weekly paclitaxel. However, the paclitaxel regimen was not effective. Therefore, we returned to the former regimen. However, the pleural effusion was refractory to that regimen, and increased. We then added 5-FU to the regimen. This addition again brought a decrease in the pleural effusion, suggesting that the additional administration of UFT is effective against refractory malignant pleural effusion after the treatment regimen with GEM and VNR.
Kawasaki
Yuji
Y
Dept. of Internal Medicine, Yonago National Hospital.
Koshohbu
Tomoaki
T
Nakatani
Shigeru
S
Matsumoto
Shingo
S
Yasuda
Kazuhito
K
Hitsuda
Yutaka
Y
Shimizu
Eiji
E
D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D016066:Pleural Effusion, Malignant / Q000188:drug therapy*; D005641:Tegafur / Q000008:administration & dosage*; D014498:Uracil / Q000008:administration & dosage*; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000077235:Vinorelbine; D000093542:Gemcitabine
D004338:Drug Combinations; C096910:UFT(R) drug; D003841:Deoxycytidine; D005641:Tegafur; D014498:Uracil; D014747:Vinblastine; D000077235:Vinorelbine; D000093542:Gemcitabine