Pyrrolidine carbamate nucleic acids: synthesis and DNA binding studies.
An efficient solid phase synthesis of pyrrolidine carbamate nucleic acids is reported. The protected (2S, 4S)-4-aminopyrrolidine-2-methanol with nucleobases thymine and cytosine attached to the ring nitrogen through an acetyl linker can be activated as nitrophenyl carbonates for the synthesis of dimer, trimer and oligomers.
Meena
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, 411008, Pune, India.
Kumar
Vaijayanti A
VA
D001483:Base Sequence; D002219:Carbamates / Q000737:chemistry*; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation / Q000528:radiation effects; D011759:Pyrrolidines / Q000737:chemistry*; D013696:Temperature; D014466:Ultraviolet Rays
D002219:Carbamates; D011759:Pyrrolidines; D004247:DNA; C032519:pyrrolidine