Development of studies of TPO gene and its application in nuclear medicine.
Thyroperoxidase (TPO) is a glycosylated protein bound to the apical plasma membrane of thyrocytes. It is the key enzyme in the synthesis of thyroid hormones. Its gene structure and transcriptional regulation have been studied in detail. This article reviews the structure, function and transcriptional regulation of the TPO gene, and the relationship between TPO, thyroid diseases and radioactive iodide therapy.
Xing
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Department of Nuclear Medicine, West China Hospital, sichuan University, Chengdu, Sichuan Province, China.
Kuang
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D000595:Amino Acid Sequence; D000818:Animals; D001324:Autoantigens / Q000737:chemistry / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000201:enzymology*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007453:Iodide Peroxidase / Q000737:chemistry / Q000378:metabolism*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D033862:Iron-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D009683:Nuclear Medicine / Q000379:methods; D013959:Thyroid Diseases / Q000201:enzymology / Q000532:radiotherapy; D013961:Thyroid Gland / Q000201:enzymology*; D013964:Thyroid Neoplasms / Q000201:enzymology* / Q000532:radiotherapy*
D001324:Autoantigens; D014408:Biomarkers, Tumor; D007457:Iodine Radioisotopes; D033862:Iron-Binding Proteins; C056658:TPO protein, human; D007453:Iodide Peroxidase