Cardiac troponin I release and cytokine response during experimental human endotoxaemia.
OBJECTIVE
To study the relationship between cytokine levels and cardiac troponin I (cTnI).


METHODS
Prospective experimental study.


METHODS
Intensive care unit of a university hospital.


METHODS
Six healthy male volunteers. INTERVENTIONS. Endotoxin, 4 ng/kg, was given as a 1-min intravenous infusion.


RESULTS
Circulating cardiac troponin I levels and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8) were analysed at various time points during a 24-h period. TNF-alpha appeared in the circulation 30 min after injection (T=0.5 h), reaching peak levels (5,665+/-1,910 pg/ml) 2 h after infusion. At T=24 h TNF-alpha was still elevated in the circulation compared to T=0. None of the six volunteers had a cTnI value higher than 0.1 microg/l at T=0, 6 h or 24 h.


CONCLUSIONS
The presence of significant amounts of TNF-alpha, IL-6 and IL-8 in the systemic circulation does not lead to increased levels of cTnI in experimental human endotoxaemia.
van Bockel
Esther A P
EA
Intensive and Respiratory Care Unit, Department of Internal Medicine, University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
Tulleken
Jaap E
JE
Muller Kobold
Anneke C
AC
Ligtenberg
Jack J M
JJ
van der Werf
Tjip S
TS
Spanjersberg
Rob
R
Zijlstra
Jan G
JG
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D001831:Body Temperature / Q000502:physiology; D003402:Creatine Kinase / Q000097:blood; D016207:Cytokines / Q000097:blood*; D019446:Endotoxemia / Q000097:blood* / Q000503:physiopathology; D004927:Escherichia coli Infections / Q000097:blood* / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D011446:Prospective Studies; D019210:Troponin I / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D019210:Troponin I; D014409:Tumor Necrosis Factor-alpha; D003402:Creatine Kinase