title: Circadian blood pressure pattern and cognitive function in newly diagnosed older hypertensives.
abstract: Hypertensive subjects can be subdivided in two groups, dippers and non-dippers, according to the presence or the lack of a nocturnal fall of blood pressure (BP) of over 10%. Several studies have investigated cardiovascular and cerebrovascular organ damage in the two groups with discordant results, but fewer of them analysed the relationship between circadian BP pattern and cognitive function, and none in the early phases of hypertension. To this purpose, we selected 40 older hypertensives, 23 dippers and 17 non-dippers, with newly diagnosed hypertension, never treated, who underwent to 24-h ambulatory BP monitoring (ABPM), Mini-Mental State Examination (MMSE) and recording of event-related potentials (ERPs). No significant differences between dippers and non-dippers were found in the MMSE scores and P300 latency values, as we expected, and not even in N2 wave latency values, showing that the non-dipping pattern is not associated with lower cognitive function in the early phases of hypertension.
authors.affiliation: Department of Geriatrics, 1st Institute of Medicine, La Sapienza University, Rome, Italy. paolocicconetti@tin.it
authors.forename: P
authors.initials: P
authors.lastname: Cicconetti
authors.forename: V
authors.initials: V
authors.lastname: Ciotti
authors.forename: G
authors.initials: G
authors.lastname: Monteforte
authors.forename: A
authors.initials: A
authors.lastname: Moisè
authors.forename: F
authors.initials: F
authors.lastname: Chiarotti
authors.forename: G
authors.initials: G
authors.lastname: Piccirillo
authors.forename: M
authors.initials: M
authors.lastname: Cacciafesta
mesh_terms: D000368:Aged; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology*; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology*; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D012720:Severity of Illness Index