Follicular lymphoma of the stomach: immunohistochemical and molecular genetic studies.
The gastrointestinal (GI) tract is the most common site for the development of extranodal non-Hodgkin's lymphomas, with most cases having a diffuse architectural pattern. Follicular lymphoma (FL) of the stomach is a very rare disease, and little is known about the immuno-histochemical and molecular genetic characteristics of this type of lymphoma. Despite their rarity, FLs are an important consideration in the differential diagnosis of follicular hyperplasia of mucosa-associated lymphoid tissue (MALT), a relatively frequently encountered lesion with the potential to cause significant diagnostic difficulty, especially when assessment is based on scanty biopsy material. We report a 57-year-old woman with gastric FL, and describe the results of immunohistochemical and molecular genetic studies.
Kanda
Motonobu
M
First Department of Pathology, Fukuoka University, School of Medicine, Japan.
Ohshima
Koichi
K
Suzumiya
Junji
J
Haraoka
Seiji
S
Kawasaki
Chika
C
Sakisaka
Shotaro
S
Kikuchi
Masahiro
M
D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis; D008224:Lymphoma, Follicular / Q000175:diagnosis* / Q000235:genetics; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000235:genetics
D014408:Biomarkers, Tumor; D019253:Proto-Oncogene Proteins c-bcl-2