Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries.
Fujii
Nobutaka
N
Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. nfujii@pharm.kyoto-u.ac.jp
Oishi
Shinya
S
Hiramatsu
Kenichi
K
Araki
Takanobu
T
Ueda
Satoshi
S
Tamamura
Hirokazu
H
Otaka
Akira
A
Kusano
Shuichi
S
Terakubo
Shigemi
S
Nakashima
Hideki
H
Broach
James A
JA
Trent
John O
JO
Wang
Zi-xuan
ZX
Peiper
Stephen C
SC
D000595:Amino Acid Sequence; D009842:Oligopeptides / Q000737:chemistry*; D019151:Peptide Library; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology; D011487:Protein Conformation; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors*
D009842:Oligopeptides; D019151:Peptide Library; D010456:Peptides, Cyclic; D019718:Receptors, CXCR4; C116977:T140 peptide