[A quantitative study of matrix metalloproteinases in proliferative vitreoretinopathy].
OBJECTIVE
To investigate the presence of matrix metalloproteinases (MMPs) in vitreous of patients with proliferative vitreoretinopathy (PVR). To study MMPs involved in the pathogenesis of the PVR.


METHODS
Twenty-one PVR vitreous samples were from patients who were performed pars plana vitrectomy (PPV). Twenty vitreous liquid samples were from patients with postoperative recurrent PVR after PPV. Ten vitreous samples were normal group. The activities of MMP-2 and MMP-9 were determined by quantitative gelatinase zymography.


RESULTS
MMP-2 was detected in all of PVR and normal group. Vitreous samples were obtained, whereas MMP-9 was found in 13 of 21 vitreous with preoperative PVR, average (171.52 +/- 13.17)scanning units. MMP-9 was detected in 19 of 20 vitreous with postoperative recurrent PVR, average(156.01 +/- 37.21)scanning units.


CONCLUSIONS
MMP-2 and MMP-9 were found in the vitreous of PVR. Elevated levels of MMP-9 may play a role in the development of postoperative PVR.
Zeng
Jun
J
Department of Ophthalmology, Xiangya Second Hospital, Centre-South University, Changsha, 410011, China. Zengjun@public.cs.hn.cn
Jiang
Deyong
D
Zhu
Xiaohua
X
Tang
Luosheng
L
D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000032:analysis* / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000032:analysis* / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000032:analysis / Q000378:metabolism; D012008:Recurrence; D014821:Vitrectomy; D018630:Vitreoretinopathy, Proliferative / Q000201:enzymology* / Q000601:surgery; D014822:Vitreous Body / Q000201:enzymology
D020782:Matrix Metalloproteinases; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9