title: Incidence of congenital toxoplasmosis in southern Brazil: a prospective study.
abstract: The study aimed to determine the incidence of congenital infection by Toxoplasma gondii and to describe neonatal and maternal characteristics regarding newborn infants treated at a teaching hospital in the town of Passo Fundo, State of Rio Grande do Sul, Brazil. Cord blood samples collected from 1,250 live newborns were analyzed. The laboratory diagnosis was established by the detection of Toxoplasma gondii IgM using an enzyme linked fluorescent assay. Gestational age, intrauterine growth, anthropometric measures, and prenatal characteristics were assessed. The incidence of congenital toxoplasmosis at birth was 8/10,000 (95%CI 0.2-44.5). Mean birthweight was 3,080 +/- 215.56 grams and mean gestational age was 38.43 +/- 1.88 weeks. With regard to prenatal care, 58% of the pregnant patients visited their doctors five times or more and 38.9% were serologically tested for toxoplasmosis in the first trimester of pregnancy. The incidence of congenital toxoplasmosis was similar to that found in most studies conducted in our country and abroad. Our study sample is representative of the town of Passo Fundo and therefore it is possible to consider the frequency observed as the prevalence of the disease in this town during the study period.
authors.affiliation: Hospital São Vicente de Paula, Passo Fundo, Rio Grande do Sul, Brasil.
authors.forename: Liége
authors.initials: L
authors.lastname: Mozzatto
authors.forename: Renato Soibelmann
authors.initials: RS
authors.lastname: Procianoy
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D001724:Birth Weight; D001938:Brazil / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M / Q000097:blood*; D015994:Incidence; D007231:Infant, Newborn; D015997:Neonatal Screening; D011247:Pregnancy; D011446:Prospective Studies; D012959:Socioeconomic Factors; D014122:Toxoplasma / Q000276:immunology*; D014125:Toxoplasmosis, Congenital / Q000097:blood / Q000453:epidemiology*
chemical_list: D000913:Antibodies, Protozoan; D007075:Immunoglobulin M