Effect of kainate on the synaptic transmission in hippocampal CA1 region.
OBJECTIVE
To investigate the effect of activated kainate receptor on both the excitatory and inhibitory synaptic transmission in the neurons in the hippocampal CA1 region.


METHODS
Blind whole-cell voltage-clamp recordings were performed on the CA1 pyramidal cells in adult rat hippocampal slices to examine and analyze the effect of bath-applied kainate (10 micromol/L) on CA1 afferent fiber-evoked excitatory postsynaptic currents (EPSCs) and inhibitory postsynaptic currents (IPSCs), respectively.


RESULTS
Activation of kainate receptor significantly depressed both IPSCs (P <0.01) and EPSCs (P <0.01) in neurons in the hippocampus CA1 region.


CONCLUSIONS
Activation of kainate receptors directly inhibit excitatory and inhibitory input in those neurons, which contributes to the development of epilepsy in the hippocampus by affecting the dynamic balance of the hippocampal neurons.
Liu
Zhi-liang
ZL
Institute of Neuroscience of PLA, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. zl-liu@163.net
Xu
Ru-xiang
RX
Jiang
Xiao-dan
XD
Yin
Zhen
Z
Luo
Cheng-yi
CY
Du
Mou-xuan
MX
Zou
Yu-xi
YX
D000818:Animals; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007608:Kainic Acid / Q000494:pharmacology*; D009433:Neural Inhibition / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D018092:Kainic Acid Receptors / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*
D007608:Kainic Acid; D018092:Kainic Acid Receptors