title: Human parvovirus B19 infection during the inactive stage of systemic lupus erythematosus.
abstract: A 42-year-old woman with systemic lupus erythematosus (SLE) had an episode of fever, arthralgia and anemia. In order to treat the suspected activation of SLE, the daily dose of steroid was increased, however, the anemia progressed and pancytopenia developed. Both IgM anti-B19 antibodies to human parvovirus B19 (B19) and B19 DNA were positive, and bone marrow analysis revealed pure red cell aplasia with giant proerythroblasts. High dose gamma globulin was administered and the daily dose of steroid was tapered, resulting in the improvement of her condition. B19 infection should be ruled out in cases with reactivation of autoimmune diseases.
authors.affiliation: Department of Internal Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-cho, Aoba-ku, Sendai 980-8574.
authors.forename: Takashiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Saito
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Hirabayashi
authors.forename: Hideo
authors.initials: H
authors.lastname: Harigae
authors.forename: Tomonori
authors.initials: T
authors.lastname: Ishii
authors.forename: Takao
authors.initials: T
authors.lastname: Kodera
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujii
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Munakata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D001854:Bone Marrow Cells / Q000473:pathology*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D010322:Parvoviridae Infections / Q000150:complications / Q000175:diagnosis*; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D011239:Prednisolone / Q000627:therapeutic use; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome; D005719:gamma-Globulins / Q000627:therapeutic use
chemical_list: D005719:gamma-Globulins; D011239:Prednisolone