title: Collapse and revival of glycolytic oscillation.
abstract: Glycolysis is the major source of metabolic energy in almost all living cells. A key feature of the glycolytic oscillations is their critical control by substrate injection rate. We show that in the limit of weak noise of the fluctuating substrate injection rate a new instability arises in the dynamics leading to collapse and revival of glycolytic oscillation reminiscent of "bursting" of action potential in nerve cells. The dynamical system in this limit also exhibits an interesting mirror image symmetry between growth and decay of fluctuations of the reaction product.
authors.affiliation: Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India.
authors.forename: Sandip
authors.initials: S
authors.lastname: Kar
authors.forename: Deb Shankar
authors.initials: DS
authors.lastname: Ray
mesh_terms: D000494:Allosteric Regulation; D025461:Feedback, Physiological; D006019:Glycolysis / Q000502:physiology*; D008954:Models, Biological