title: Increased endogenous endothelin-1 in coronary circulation is associated with restenosis after coronary angioplasty.
abstract: BACKGROUND
  The relationship between vasoactive substances, including endothelin-1, nitric oxide, serotonin, angiotensin II and noradrenaline, and coronary restenosis after percutaneous transluminal coronary angioplasty (PTCA) is not clear.
  
  
  OBJECTIVE
  To determine whether any vasoactive substance may be a marker of coronary restenosis after PTCA.
  
  
  METHODS
  Twenty-nine patients with angina pectoris underwent elective PTCA. Three months after PTCA, coronary angiography was performed again to study the patency of the lesions. Seven patients had coronary restenosis (greater than 50% stenosis) (restenosis group) and the rest of the patients were without restenosis (patency group). Their blood samples were obtained from the coronary sinus before, immediately after and three months after PTCA.
  
  
  RESULTS
  Endothelin-1 levels obtained immediately after PTCA (3.44+/-0.26 pg/mL) and three months after PTCA (3.57+/-0.29 pg/mL) were significantly higher than those obtained before PTCA (3.00+/-0.26 pg/mL) in the restenosis group, but not in the patency group (3.34+/-0.15 pg/mL, 3.02+/-0.17 pg/mL and 3.14+/-0.18 pg/mL, respectively). A transient decrease in nitrite/nitrate levels was observed immediately after PTCA in both groups. The serotonin levels three months after PTCA were significantly decreased in the patency group, but not in the restenosis group, and the levels of angiotensin II and noradrenaline did not change in either group throughout the study.
  
  
  CONCLUSIONS
  Among several vasoactive substances, endothelin-1 seems to be associated with the process of coronary restenosis after PTCA. Increased endothelin-1 levels in the coronary circulation after PTCA may indicate an increased risk of coronary restenosis.
authors.affiliation: Enshu General Hospital, Hamamatsu, Japan. h_takase@ken.ja-shizouka.or.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takase
authors.forename: Masaya
authors.initials: M
authors.lastname: Sugiyama
authors.forename: Ai
authors.initials: A
authors.lastname: Nakazawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Toriyama
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Hayashi
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Goto
authors.forename: Koichi
authors.initials: K
authors.lastname: Sato
authors.forename: Koshiro
authors.initials: K
authors.lastname: Ikeda
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Ueda
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Dohi
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D000804:Angiotensin II / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology*; D023903:Coronary Restenosis / Q000453:epidemiology / Q000378:metabolism* / Q000503:physiopathology*; D019332:Endothelin-1 / Q000378:metabolism*; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D012307:Risk Factors; D012701:Serotonin / Q000378:metabolism; D013223:Statistics as Topic; D014654:Vascular Patency / Q000502:physiology
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D000804:Angiotensin II; D009569:Nitric Oxide; D012701:Serotonin; D009638:Norepinephrine