Generalized anxiety disorders three to four months after ischemic stroke.
OBJECTIVE
The main objective of our study was to detail the frequency and clinical determinants of poststroke generalized anxiety disorders in a large, well-defined stroke cohort.


METHODS
A total of 277 stroke patients aged 55-85 were subjected to a comprehensive psychiatric evaluation between 3 and 4 months after ischemic stroke. Primary generalized anxiety disorder or generalized anxiety disorder due to stroke were diagnosed according to DSM-IV symptom criteria.


RESULTS
The frequency of any generalized anxiety disorder was 20.6% (n = 57). According to a logistic model, any generalized anxiety disorder was associated with a history of epilepsy, comorbid depressive disorder, severity of depression, severity of anxiety, and the use of anxiolytic drugs. A discriminant analysis identified four factors that distinguished the two diagnostic subgroups from one another: the level of psychosocial functioning (worse score in patients with generalized anxiety due to stroke), a history of migraine, anterior circulation stroke localization (more frequent in patients with generalized anxiety disorder due to stroke), and a history of insomnia (more frequent in patients with primary generalized anxiety disorder).


CONCLUSIONS
Clinically significant anxiety is common in ischemic stroke patients and may hamper their rehabilitation.
Leppävuori
Antero
A
Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.
Pohjasvaara
Tarja
T
Vataja
Risto
R
Kaste
Markku
M
Erkinjuntti
Timo
T
D000368:Aged; D000369:Aged, 80 and over; D001008:Anxiety Disorders / Q000453:epidemiology* / Q000209:etiology* / Q000523:psychology; D002545:Brain Ischemia / Q000150:complications* / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications* / Q000453:epidemiology* / Q000523:psychology; D013997:Time Factors