Autologous stem cells for functional myocardial repair.
Recent experimental studies based on innovative hypothesis utilizing cell therapy for the damaged myocardium are recently becoming increasingly promising. The naturally occurring myocardial reparative process is apparently complex and relatively inefficient. It consists of up-regulation of progenitor cell release from the bone marrow after myocardial infarction, homing of these cells to the injured tissue, and differentiation of these progenitor cells into vascular cells and cardiomyocytes within the infarcted tissue. Accordingly, there are two main strategies to regenerate myocardium with autologous stem cells: (1) Extracting stem cells from the bone marrow and injecting these cells into the damaged area, (2) Increasing the efficiency of the naturally occurring reparative process by increasing the mobilization of bone marrow-derived stem cells after myocardial infarction. This review summarizes the growing field of autologous stem cell utilization over the past decade and outlines scientific and clinical hurdles that need to be overcome before this therapy can fully reach its clinical potential.
Schwartz
Yitzhack
Y
Rambam Medical Center, Cardiology Division, Haifa, Israel. rkornowski@clalit.org.il
Kornowski
Ran
R
D006333:Heart Failure / Q000601:surgery; D006801:Humans; D017202:Myocardial Ischemia / Q000503:physiopathology* / Q000601:surgery*; D009206:Myocardium / Q000166:cytology / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000502:physiology / Q000637:transplantation; D012038:Regeneration; D033581:Stem Cell Transplantation / Q000639:trends; D014182:Transplantation, Autologous / Q000639:trends