title: Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20.
abstract: In a search for novel growth factors, we discovered that human interleukin-20 (IL-20) enhanced colony formation by CD34+ multipotential progenitors. IL-20 had no effect on erythroid, granulocyte-macrophage, or megakaryocyte progenitors. IL-20 transgenic mice increased the numbers and cell cycling of multipotential but not other progenitors. IL-20 administration to normal mice significantly increased only multipotential progenitor cells, demonstrating that IL-20 significantly influences hematopoiesis, with specificity toward multipotential progenitors. This is the first cytokine with such specificity identified.
authors.affiliation: Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA. liu_ling@lilly.com
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: Chunjin
authors.initials: C
authors.lastname: Ding
authors.forename: Wei
authors.initials: W
authors.lastname: Zeng
authors.forename: Josef G
authors.initials: JG
authors.lastname: Heuer
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Tetreault
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Noblitt
authors.forename: Giao
authors.initials: G
authors.lastname: Hangoc
authors.forename: Scott
authors.initials: S
authors.lastname: Cooper
authors.forename: Kellie A
authors.initials: KA
authors.lastname: Brune
authors.forename: Ganesh
authors.initials: G
authors.lastname: Sharma
authors.forename: Niles
authors.initials: N
authors.lastname: Fox
authors.forename: Scott W
authors.initials: SW
authors.lastname: Rowlinson
authors.forename: Danise P
authors.initials: DP
authors.lastname: Rogers
authors.forename: Derrick R
authors.initials: DR
authors.lastname: Witcher
authors.forename: Peter K
authors.initials: PK
authors.lastname: Lambooy
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Wroblewski
authors.forename: James R
authors.initials: JR
authors.lastname: Miller
authors.forename: Hal E
authors.initials: HE
authors.lastname: Broxmeyer
mesh_terms: D000818:Animals; D018952:Antigens, CD34; D001854:Bone Marrow Cells / Q000166:cytology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005312:Fetal Blood / Q000166:cytology; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D007378:Interleukins / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008822:Mice, Transgenic; D039902:Multipotent Stem Cells / Q000166:cytology / Q000187:drug effects*
chemical_list: D018952:Antigens, CD34; D007378:Interleukins; C422042:interleukin 20