Nicotine lowers the body-weight set-point in male rats.
Set-point of body weight was assessed by the behavioral method of the weight threshold to hoard food. Intra-peritoneal injection of nicotine (0.02-0.05 mg/kg) significantly lowered the rats' body weight set-point by 8.5+/-2.7 and 19.2+/-2.6 g (p< or =0.05). These results suggest that the administration of low-dose nicotine lowers the body-weight set-point and may be important in predicting the anticipated gain in weight frequently reported upon withdrawal.
Frankham
Patrick
P
Département de Physiologie, Faculte de Medecine, Université Laval, Québec, G1K 7P4 Canada.
Cabanac
Michel
M
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D005731:Ganglionic Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D005731:Ganglionic Stimulants; D009538:Nicotine