Blunted metabolic response to SKF 82958 in the mesolimbic system following preweaning cocaine treatment.
This study examined glucose metabolic rates following dopamine D(1) agonist challenge in adult male rats pretreated with cocaine during postnatal days 11-20. Water-pretreated control rats showed a reliable decrease in glucose metabolism of rostral mesolimbic structures when challenged with SKF 82958 while cocaine-pretreated males did not. These data support the notion that cocaine exposure during the preweaning period dampens D(1) receptor-mediated function and that the mesolimbic system exhibits a selective vulnerability to early cocaine exposure.
Melnick
Susan M
SM
Laboratory of Cerebral Metabolism, Department of Physiology/Pharmacology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Box #29, Brooklyn, NY 11203, USA.
Dow-Edwards
Diana L
DL
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D008032:Limbic System / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D014886:Weaning
D001552:Benzazepines; D018491:Dopamine Agonists; D018765:Dopamine Uptake Inhibitors; C071262:SK&F 82958; D003042:Cocaine; D005947:Glucose