title: Gold(III) porphyrins as a new class of anticancer drugs: cytotoxicity, DNA binding and induction of apoptosis in human cervix epitheloid cancer cells.
abstract: A series of gold(III) tetraarylporphyrins are stable in the presence of glutathione and exert much higher potency than cisplatin in killing human cancer cells, including the drug-resistant variants; the gold-induced cytotoxicity occurs through an apoptotic pathway according to laser confocal microscopy and flow cytometric studies.
authors.affiliation: Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong. cmche@hku.hk
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
authors.forename: Raymond Wai-Yin
authors.initials: RW
authors.lastname: Sun
authors.forename: Wing-Yiu
authors.initials: WY
authors.lastname: Yu
authors.forename: Chi-Bun
authors.initials: CB
authors.lastname: Ko
authors.forename: Nianyong
authors.initials: N
authors.lastname: Zhu
authors.forename: Hongzhe
authors.initials: H
authors.lastname: Sun
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D004247:DNA / Q000737:chemistry*; D005260:Female; D017612:Gold Compounds / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D011166:Porphyrins / Q000737:chemistry / Q000633:toxicity*; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology; D014407:Tumor Cells, Cultured; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D017612:Gold Compounds; D011166:Porphyrins; D004247:DNA