[Change in the level of inflammatory cytokines and their relationship to the indicator in evaluating renal tubules injury of urinary in neonates with asphyxia].
OBJECTIVE
To explore the relationship between amount of inflammatory cytokines in urine and neonatal postasphyxia renal tubules injury.


METHODS
The level of inflammatory cytokines such as interleukin (IL-8, IL-6), tumor necrosis factor-alpha (TNF-alpha) and the indicators of evaluating renal tubules injury [N-acetyl-glucosaminidase(NAG), gamma-glutamyltranspeptidase (gamma-GT), beta(2)-microglobulin (beta(2)-MG)] in urine were detected in neonates with asphyxia.


RESULTS
Compared with control, the levels of IL-8, IL-6, TNF-alpha and NAG, gamma-GT, beta2-MG were obviously increased in mild asphyxia group. In severe asphyxia group, the parameters above were all significantly increased compared with mild asphyxia group and the control group. Within the asphyxia group, there were positive relationship between inflammatory cytokines and the indicator of evaluating renal tubules injury.


CONCLUSIONS
The asphyxia may induce systemic inflammatory response syndrome (SIRS), which result in postasphyxia renal injury in neonates. The level of inflammatory cytokines in urine may be used as the indicators of evaluating the severity of asphyxia and postasphyxia renal injury in neonates.
Dong
Wen-bin
WB
Department of Pediatrics, Affiliated Hospital, Luzhou Medical College, Luzhou 646000, Sichuan, China.
Tang
Zhang-hua
ZH
Chen
Hong-ying
HY
Chen
Shu-qin
SQ
Wang
Xing-yong
XY
Wang
Sheng-hui
SH
Zhai
Xue-song
XS
Xiao
Da-cheng
DC
D000118:Acetylglucosaminidase / Q000378:metabolism; D001238:Asphyxia Neonatorum / Q000473:pathology / Q000652:urine*; D016022:Case-Control Studies; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation; D015850:Interleukin-6 / Q000652:urine*; D016209:Interleukin-8 / Q000652:urine*; D007684:Kidney Tubules / Q000378:metabolism* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000652:urine*; D001613:beta 2-Microglobulin / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D001613:beta 2-Microglobulin; D005723:gamma-Glutamyltransferase; C554782:gamma-glutamyltransferase, human; D000118:Acetylglucosaminidase