Prospective study of fibrinolytic markers and venous thromboembolism.
Prior research has conflicted on whether increased levels of plasma fibrinolytic factors may identify patients at risk of venous thromboembolism (VTE). We therefore performed a nested case-control study of VTE within two prospective population-based studies. In 308 participants who developed VTE and 640 controls, we measured PAI-1 antigen, tPA/PAI-1 complex, plasmin-alpha 2-antiplasmin (PAP), and the PAI-1 -675 4G/5G promoter polymorphism on pre-event blood samples. There was no overall association between any of these fibrinolytic variables and VTE, after adjustment for age or for multiple VTE risk factors. There was weak evidence for an interaction of PAP with elevated factor VIIIc and elevated D-dimer in augmenting VTE risk. We conclude that, for the most part, these fibrinolytic markers do not identify healthy subjects at risk for VTE.
Folsom
Aaron R
AR
Division of Epidemiology, School of Public Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454-1015, USA. folsom@epi.umn.edu
Cushman
Mary
M
Heckbert
Susan R
SR
Rosamond
Wayne D
WD
Aleksic
Nena
N
D000368:Aged; D000933:Antifibrinolytic Agents / Q000097:blood; D015415:Biomarkers / Q000097:blood; D029742:Caenorhabditis elegans Proteins; D016022:Case-Control Studies; D005260:Female; D005341:Fibrinolysin / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011379:Prognosis; D011446:Prospective Studies; D011505:Protein-Tyrosine Kinases / Q000097:blood; D012307:Risk Factors; D013923:Thromboembolism / Q000097:blood* / Q000209:etiology; D020246:Venous Thrombosis / Q000097:blood* / Q000209:etiology; D000979:alpha-2-Antiplasmin
D000933:Antifibrinolytic Agents; D015415:Biomarkers; D029742:Caenorhabditis elegans Proteins; D017395:Plasminogen Activator Inhibitor 1; D000979:alpha-2-Antiplasmin; C037742:plasmin-plasmin inhibitor complex; C095371:TPA-1 protein, C elegans; D011505:Protein-Tyrosine Kinases; D005341:Fibrinolysin