MDR1 C3435T genetic polymorphism does not influence the response to antiretroviral therapy in drug-naive HIV-positive patients.
P-glycoprotein, a membrane-localized protein transporter, codified by the MDR1 gene, influences the response to pharmacological treatments, including antiretroviral drugs. MDR1 polymorphism C3435T is correlated with the functionality of the protein. We investigated the influence of this polymorphism in the reconstitution of the peripheral CD4 T cell pool in 149 drug-naive HIV-positive patients starting highly active antiretroviral therapy. The MDR1 C3435Tpolymorphism did not influence response to therapy, suggesting no disadvantages for individuals with a different genotype.
Nasi
Milena
M
Department of Biomedical Sciences, University of Modena and Reggio Emilia School of Medicine, via Campi 287, 41100 Modena, Italy.
Borghi
Vanni
V
Pinti
Marcello
M
Bellodi
Cristian
C
Lugli
Enrico
E
Maffei
Stefania
S
Troiano
Leonarda
L
Richeldi
Luca
L
Mussini
Cristina
C
Esposito
Roberto
R
Cossarizza
Andrea
A
D018791:CD4 Lymphocyte Count; D019450:Genes, MDR; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics* / Q000276:immunology; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D011110:Polymorphism, Genetic; D016896:Treatment Outcome
D017320:HIV Protease Inhibitors