title: Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm.
abstract: Endogenous formation of nitric oxide (NO) and related nitrogen oxides in the vascular system is critical to regulation of multiple physiological functions. An imbalance in the production or availability of these species can result in progression of disease. Nitrogen oxide research in the cardiovascular system has primarily focused on the effects of NO and higher oxidation products. However, nitroxyl (HNO), the one-electron-reduction product of NO, has recently been shown to have unique and potentially beneficial pharmacological properties. HNO and NO often induce discrete biological responses, providing an interesting redox system. This article discusses the emerging aspects of HNO chemistry and attempts to provide a framework for the distinct effects of NO and HNO in vivo.
authors.affiliation: Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bldg. 10, Rm. B3-B69, Bethesda, MD 20892, USA. wink@box-w.nih.gov
authors.forename: David A
authors.initials: DA
authors.lastname: Wink
authors.forename: Katrina M
authors.initials: KM
authors.lastname: Miranda
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Katori
authors.forename: Daniele
authors.initials: D
authors.lastname: Mancardi
authors.forename: Douglas D
authors.initials: DD
authors.lastname: Thomas
authors.forename: Lisa
authors.initials: L
authors.lastname: Ridnour
authors.forename: Michael G
authors.initials: MG
authors.lastname: Espey
authors.forename: Martin
authors.initials: M
authors.lastname: Feelisch
authors.forename: Carol A
authors.initials: CA
authors.lastname: Colton
authors.forename: Jon M
authors.initials: JM
authors.lastname: Fukuto
authors.forename: Pasquale
authors.initials: P
authors.lastname: Pagliaro
authors.forename: David A
authors.initials: DA
authors.lastname: Kass
authors.forename: Nazareno
authors.initials: N
authors.lastname: Paolocci
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000378:metabolism*; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism*; D009589:Nitrogen Oxides / Q000378:metabolism*; D010084:Oxidation-Reduction; D015398:Signal Transduction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology*
chemical_list: D009589:Nitrogen Oxides; D009569:Nitric Oxide; C039900:nitroxyl