Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis.
OBJECTIVE
To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan.


METHODS
The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls by polymerase chain reaction (PCR)/restriction fragment length polymorphisms (RFLP) methods.


RESULTS
The genotype frequency of CYP1A1 4887C/A was significantly lower in patients with AS than in controls. The phenotype frequency of CYP1A1 4887A also tended to be decreased in patients with AS. There were no significant differences in the genotype, allele, and phenotype frequencies of MnSOD gene polymorphisms between patients with AS and controls.


CONCLUSIONS
CYP1A1 4887A may be a protective factor for the development of AS in Taiwan. However, MnSOD gene polymorphisms are not associated with the susceptibility to AS.
Yen
Jeng-Hsien
JH
Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, No. 100 Shih-Chuan 1st Road, Kaohsiung 807, Kaohsiung City, Taiwan. jehsye@kmu.edu.tw
Tsai
Wen-Chun
WC
Chen
Chung-Jen
CJ
Lin
Chia-Hui
CH
Ou
Tsan-Teng
TT
Hu
Chaur-Jong
CJ
Liu
Hong-Wen
HW
D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D013167:Spondylitis, Ankylosing / Q000235:genetics*; D013482:Superoxide Dismutase / Q000235:genetics*; D013624:Taiwan
D019363:Cytochrome P-450 CYP1A1; D013482:Superoxide Dismutase