Lymphomatoid drug eruption mimicking digitate dermatosis: cross reactivity between two drugs that suppress angiotensin II function.
A 75-year-old male presented with an eruption characteristic of digitate dermatosis. The eruption cleared completely after discontinuation of lisinopril (angiotensin converting enzyme inhibitor). Eighteen months later a similar eruption recurred after using valsartan (a competitive inhibitor of angiotensin II receptor). The eruption cleared after discontinuation of valsartan. Histologic findings in both eruptions were consistent with lymphomatoid drug eruption. This case is interesting in that the eruption occurred after the intake of two structurally unrelated drugs that interfere with angiotensin II function. This observation may shed light on the mechanisms that may be operative in provoking the lymphomatoid drug eruption.
Mutasim
Diya F
DF
Department of Dermatology, University of Cincinnati, Ohio 45267-0592, USA. diya.mutasim@uc.edu
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000209:etiology / Q000473:pathology*; D006229:Hand Dermatoses / Q000139:chemically induced / Q000473:pathology*; D006801:Humans; D017706:Lisinopril / Q000009:adverse effects*; D008297:Male; D019310:Pseudolymphoma / Q000209:etiology / Q000473:pathology*; D013777:Tetrazoles / Q000009:adverse effects*; D014633:Valine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D000068756:Valsartan
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D013777:Tetrazoles; D000068756:Valsartan; D017706:Lisinopril; D014633:Valine