title: Clinical trials in isolated systolic hypertension in the elderly.
abstract: The presence of isolated systolic hypertension in elderly subjects predisposes to the development of coronary artery disease, myocardial infarction, heart failure, cardiovascular events, stroke and cardiovascular mortality. Whether pharmacologic management of isolated systolic hypertension in the elderly is justified or not has not received attention until the recent years. In this era of the practice of evidence based medicine it is important to review the results of clinical trials about the management of isolated systolic hypertension involving thousands of elderly patients. The main trials and their results will be presented. These demonstrate a 17% reduction in total mortality, 25% reduction in cardiovascular mortality, 37% reduction in stroke and a 25% reduction in myocardial infarction for those patients under pharmacologic treatment.
authors.affiliation: School of Medicine, University of Puerto Rico.
authors.forename: Mario R
authors.initials: MR
authors.lastname: García-Palmieri
authors.forename: José M
authors.initials: JM
authors.lastname: Torrado
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000401:mortality / Q000517:prevention & control; D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D013599:Systole
chemical_list: D000959:Antihypertensive Agents