title: Spiroimidazolidinone library derivatives on SynPhase lanterns.
abstract: Optimization and solid-phase synthesis of new spiroimidazolidinone derivatives as highly functionalized templates is reported. The synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives was performed on SynPhase lanterns from dipeptides anchored on the solid support and N-protected piperidone. A library of 180 discrete compounds was prepared.
authors.affiliation: Laboratoire des Amino acides Peptides et Protéines - UMR-CNRS 5810, Faculté de Pharmacie, Avenue Charles Flahault, 34000 Montpellier, France.
authors.forename: Lidia
authors.initials: L
authors.lastname: Feliu
authors.forename: Gilles
authors.initials: G
authors.lastname: Subra
authors.forename: Jean
authors.initials: J
authors.lastname: Martinez
authors.forename: Muriel
authors.initials: M
authors.lastname: Amblard
mesh_terms: D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007093:Imidazoles; D013141:Spiro Compounds