title: Pattern of recurrence after surgery in adenocarcinoma of the gastro-oesophageal junction.
abstract: OBJECTIVE
  This study reports mode, timing and predictive factors of recurrence after curative surgery for cardia cancer.
  
  
  METHODS
  A prospective study in a series of 92 curatively (R0) resected patients from 1988 to 2002.
  
  
  RESULTS
  The 5-year recurrence rate was 71%. Lymph node involvement was the only predictor of recurrence. No patients with more than 6 metastatic nodes were free from relapse 2 years after surgery. Locoregional, peritoneal and haematogenous relapses showed a similar median recurrence time (12, 10 and 12 months, respectively), 80% occurred within 24 months.
  
  
  CONCLUSIONS
  Few patients can be cured by surgery, lymph nodal involvement is the only predictor of recurrence.
authors.affiliation: First Department of General Surgery, University of Verona, Verona, Italy. chirurgia.urgenza@univr.it
authors.forename: G
authors.initials: G
authors.lastname: de Manzoni
authors.forename: C
authors.initials: C
authors.lastname: Pedrazzani
authors.forename: F
authors.initials: F
authors.lastname: Pasini
authors.forename: E
authors.initials: E
authors.lastname: Durante
authors.forename: M
authors.initials: M
authors.lastname: Gabbani
authors.forename: A
authors.initials: A
authors.lastname: Grandinetti
authors.forename: A
authors.initials: A
authors.lastname: Guglielmi
authors.forename: C
authors.initials: C
authors.lastname: Griso
authors.forename: C
authors.initials: C
authors.lastname: Cordiano
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary* / Q000601:surgery*; D000328:Adult; D000368:Aged; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery*; D016629:Esophagectomy; D004943:Esophagogastric Junction / Q000473:pathology / Q000601:surgery; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery*; D016019:Survival Analysis; D013997:Time Factors