The pharmacology of diabetic complications.
In spite of the significant developments in antidiabetic therapy, diabetic complications, particularly seen in long-term diabetes, continue to be seriously deleterious. Various types of diabetic complications affecting different systems in the body have been reported. The clinical course of the disease is largely determined by those complications. Therefore, an important area is obviously prevention or treatment of the disabling complications associated with diabetes. Recent investigations address to the problem from different angles, since the development of diabetes-induced long-term problems is likely a multifactorial process. In this review, some of the factors which are implicated in the development of these complications such as neuropathy, retinopathy and cataract are discussed. Some of the approaches which have been used in attempts to prevent or delay those abnormalities are reported as well.
Altan
V Melih
VM
Department of Pharmacology, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey. maltan@pharmacy.ankara.edu.tr
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors / Q000378:metabolism; D002386:Cataract / Q000188:drug therapy* / Q000517:prevention & control; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000517:prevention & control; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000517:prevention & control; D003930:Diabetic Retinopathy / Q000188:drug therapy* / Q000517:prevention & control; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000494:pharmacology / Q000627:therapeutic use; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors; D006801:Humans; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use
D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D017127:Glycation End Products, Advanced; D014665:Vasodilator Agents; D000449:Aldehyde Reductase