title: [Hygienic evaluation of the combined effect of electromagnetic fields and pesticides in experimental conditions].
abstract: The paper deals with the evaluation of combined effects of some natural and anthropogenic factors that are typical of the Kursk magnetic anomaly region by means of dispersion analysis in the experiments on albino rats and mice. The resultant signs were the indices of animal deaths, nonspecific protective factors, immune responses, changes in body weight, etc. A higher geomagnetic field can modify the biological effects of exposure to agricultural chemicals. The combined effects of a static electromagnetic field with induction of 300 microT to 0.3 T and of chlorpyrifos at various concentrations (0.1, 1, 50, and 100 mg/kg) were found to potentiate the toxic properties of the pesticide. The proportion of the potentiation effects increased as the intensity of the studied factors rose. The dispersion analysis established a predominant role of chlorpyrifos in the combined effects of the factors on the death of animals, serum complementary activity, antibody- and rosette-forming cells of the spleen and other lymphoid organs. The role of a static electromagnetic field is prevalent in the formation of effects of the intensity and completeness of phagocytosis.
authors.forename: A M
authors.initials: AM
authors.lastname: Chernykh
mesh_terms: D000818:Animals; D004390:Chlorpyrifos / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004574:Electromagnetic Fields; D007306:Insecticides / Q000633:toxicity*; D012426:Russia
chemical_list: D007306:Insecticides; D004390:Chlorpyrifos