A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila.
Nucleotide sequence analysis of an approximately 80-kb genomic region revealed an approximately 65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system, mobile genetic elements, and known virulence factors. Comparative studies with other Legionella pneumophila strains and serogroups indicated that this approximately 65-kb locus is unique to L. pneumophila serogroup 1 Philadelphia-1 strains.
Brassinga
Ann Karen C
AK
Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7.
Hiltz
Margot F
MF
Sisson
Gary R
GR
Morash
Michael G
MG
Hill
Nathan
N
Garduno
Elizabeth
E
Edelstein
Paul H
PH
Garduno
Rafael A
RA
Hoffman
Paul S
PS
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics*; D002876:Chromosomes, Bacterial / Q000235:genetics*; D016000:Cluster Analysis; D006801:Humans; D016952:Legionella pneumophila / Q000235:genetics* / Q000472:pathogenicity*; D008969:Molecular Sequence Data; D005810:Multigene Family; D014774:Virulence
D001426:Bacterial Proteins