title: Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1-E2-Origin DNA complex.
abstract: We have discovered a series of inhibitors of the assembly of the HPV11 E1-E2-origin DNA complex, which incorporate an indandione fused to a substituted tetrahydrofuran.
authors.affiliation: Department of Chemistry, Boehringer Ingelheim (Canada) Ltd., 2100 Cunard Street, Laval, Québec, Canada H7S 2G5. cyoakim@lav.boehringer-ingelheim.com
authors.forename: Christiane
authors.initials: C
authors.lastname: Yoakim
authors.forename: William W
authors.initials: WW
authors.lastname: Ogilvie
authors.forename: Nathalie
authors.initials: N
authors.lastname: Goudreau
authors.forename: Julie
authors.initials: J
authors.lastname: Naud
authors.forename: Bruno
authors.initials: B
authors.lastname: Haché
authors.forename: Jeff A
authors.initials: JA
authors.lastname: O'Meara
authors.forename: Michael G
authors.initials: MG
authors.lastname: Cordingley
authors.forename: Jacques
authors.initials: J
authors.lastname: Archambault
authors.forename: Peter W
authors.initials: PW
authors.lastname: White
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004279:DNA, Viral / Q000096:biosynthesis*; D015195:Drug Design; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D027383:Papillomaviridae / Q000187:drug effects*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014764:Viral Proteins / Q000096:biosynthesis / Q000235:genetics; D019065:Virus Assembly / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D014764:Viral Proteins