[Effect of xinmaitong on wild-type p53 gene expression in rabbits with carotid endothelial injury].
OBJECTIVE
To explore the mechanism of prevention and treatment of post-PTCA restenosis with Xinmaitong (XMT).


METHODS
Rabbit carotid endothelial injury model was established using Fishman air drying method. Effect of XMT on model rabbits wild-type p53 gene expression was observed by tissue in situ hybridization.


RESULTS
p53 gene expression appeared on the 3 days after operation, enhanced on the 7 days, reached the peak on the 14th day, weakened on the 21th, and still showed on the 28th day. The strongest expression was shown in rabbits treated by XMT, second in those treated by Warfarin, and the weakest in the operated control group.


CONCLUSIONS
XMT could promote the high expression of wild-type p53 gene expression in rabbit with carotid endothelial injury, which is possibly one of the important mechanism of XMT in preventing and treating arterial restenosis.
Guan
Chang-yi
CY
Xiamen Hospital of TCM, Fujian 361000.
Zhang
Wen-gao
WG
Zhou
Su-ning
SN
D000818:Animals; D002339:Carotid Arteries / Q000473:pathology; D023903:Coronary Restenosis / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology*; D008517:Phytotherapy; D011817:Rabbits; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis* / Q000235:genetics
D004365:Drugs, Chinese Herbal; D016159:Tumor Suppressor Protein p53