Melanocortin system and eating disorders.
The melanocortin (MC) system is involved in the regulation of energy balance and in the development of obesity. Here we briefly review why we became interested in investigating whether the MC system - more particularly, the increased activity of the MC system - is also involved in disorders of negative energy balance. We provide evidence that suppression of increased MC receptor activity by treatment with the inverse agonist agouti-related peptide (AgRP) (83-132) rescues rats exposed to an animal model known as activity-based anorexia. Furthermore, we found a polymorphism, Ala67Thr AgRP, that was observed more frequently in anorexia nervosa.
Adan
Roger A H
RA
Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Centre Utrecht, Utrecht, the Netherlands. r.a.h.adan@med.uu.nl
Hillebrand
Jacquelien J G
JJ
De Rijke
Corine
C
Nijenhuis
Wouter
W
Vink
Tom
T
Garner
Keith M
KM
Kas
Martien J H
MJ
D054369:Agouti-Related Protein; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001665:Binding Sites; D001068:Feeding and Eating Disorders / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology; D010455:Peptides / Q000378:metabolism / Q000627:therapeutic use; D010913:Pituitary-Adrenal System / Q000502:physiology; D011110:Polymorphism, Genetic; D011333:Pro-Opiomelanocortin / Q000235:genetics / Q000378:metabolism*; D011506:Proteins / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use; D051381:Rats; D018043:Receptors, Corticotropin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D044101:Receptors, Melanocortin; D013217:Starvation / Q000188:drug therapy; D000521:alpha-MSH / Q000378:metabolism*
D054369:Agouti-Related Protein; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D011506:Proteins; D018043:Receptors, Corticotropin; D044101:Receptors, Melanocortin; C103272:SHU 9119; D000521:alpha-MSH; D011333:Pro-Opiomelanocortin; D009074:Melanocyte-Stimulating Hormones