Prevention of reperfusion lung injury by lidocaine in isolated rat lung ventilated with higher oxygen levels.
BACKGROUND
Lidocaine, an antiarrhythmic drug has been shown to be effective against post-ischaemic reperfusion injury in heart. However, its effect on pulmonary reperfusion injury has not been investigated.


OBJECTIVE
We investigated the effects of lidocaine on a postischaemic reperfused rat lung model.


METHODS
Lungs were isolated and perfused at constant flow with Krebs-Henseilet buffer containing 4% bovine serum albumin, and ventilated with 95% oxygen mixed with 5% CO2. Lungs were subjected to ischaemia by stopping perfusion for 60 minutes followed by reperfusion for 10 minutes. Ischaemia was induced in normothermic conditions.


RESULTS
Postischaemic reperfusion caused significant (p < 0.0001) higher wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure compared to control lungs. Lidocaine, at a dose of 5mg/Kg b.w. was found to significantly (p < 0.0001) attenuate the increase in the wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure observed in post-ischaemic lungs.


CONCLUSIONS
Lidocaine is effective in preventing post-ischaemic reperfusion injury in isolated, perfused rat lung.
Das
K C
KC
University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708, USA. kumuda@uthct.edu
Misra
H P
HP
D000818:Animals; D008012:Lidocaine / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects*; D008297:Male; D023421:Models, Animal; D010100:Oxygen / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000517:prevention & control*
D008012:Lidocaine; D010100:Oxygen