Pyrrolo[2,3-h]quinolinones: synthesis and photochemotherapic activity.
A series of derivatives of the new ring system pyrrolo[2,3-h]quinoline-2-one was synthesized and evaluated as photoreagents toward cultured human tumor cells. Remarkable phototoxycity resulted for some derivatives, especially those bearing the phenyl group at the 7-position.
Barraja
Paola
P
Dipartimento Farmacochimico, Tossicologico e Biologico Università degli Studi, Via Archirafi 32, 90123 Palermo, Italy.
Diana
Patrizia
P
Lauria
Antonino
A
Montalbano
Alessandra
A
Almerico
Anna Maria
AM
Dattolo
Gaetano
G
Cirrincione
Girolamo
G
Viola
Giampietro
G
Dall'Acqua
Francesco
F
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005354:Fibrosarcoma; D006801:Humans; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D011758:Pyrroles; D015363:Quinolones