title: Mating attenuates aging-associated increase of lipid peroxidation activity in C57BL/6J mice.
abstract: In the frame of the free-radical hypothesis of aging and literature data on increased life span of mated animals, we evaluated brain, kidney, and liver lipid peroxidation in C57Bl/6J mice of various ages and compared lipid peroxidation activity in mated and non-mated mice of both genders. An aging-associated increase (from 3 to 12 months of age) of lipid peroxidation, as measured by malonaldehyde and 4-hydroxyalkenals (MDA + HAE) levels, was observed in the liver and kidney, but not in the brain. Tissue MDA + HAE levels were lower in 12-month old mated mice (housed with animals of opposite gender from three to five months of age) than in 12-month old non-mated animals. There were no gender differences in the observed effect. It is suggested that mating might attenuate the increase of lipid peroxidation associated with aging.
authors.affiliation: Pineal Research Laboratory, Department of Psychiatry, St. Elizabeth's Medical Center, Boston, Massachusets 02135, USA. gregory_oxenkrug@cchcs.org
authors.forename: Gregory F
authors.initials: GF
authors.lastname: Oxenkrug
authors.forename: Pura J
authors.initials: PJ
authors.lastname: Requintina
mesh_terms: D000375:Aging; D000475:Alkenes / Q000032:analysis; D000818:Animals; D001835:Body Weight; D001923:Brain Chemistry; D005260:Female; D007668:Kidney / Q000737:chemistry; D015227:Lipid Peroxidation; D008099:Liver / Q000737:chemistry; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D012726:Sexual Behavior, Animal
chemical_list: D000475:Alkenes; D008315:Malondialdehyde