Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats.
OBJECTIVE
To investigate the effect of tetramethylpyrazine on hepatic/renal ischemia and reperfusion injury in rats.


METHODS
Hepatic/renal function, histopathological changes, and hepatic/renal P-selectin expression were studied with biochemical measurement and immunohistochemistry in hepatic/renal ischemia and reperfusion injury in rat models.


RESULTS
Hepatic/renal insufficiency and histopathological damage were much less in the tetramethylpyrazine-treated group than those in the saline-treated groups. Hepatic/renal P-selectin expression was down regulated in the tetramethylpyrazine-treated group.


CONCLUSIONS
P-selectin might mediate neutrophil infiltration and contribute to hepatic/renal ischemia and reperfusion injury. Tetramethylpyrazine might prevent hepatic/renal damage induced by ischemia and reperfusion injury through inhibition of P-selectin.
Chen
Jin-Lian
JL
Department of Gastroenterology, Shanghai Sixth People's Hospital, Shanghai Jiao-Tong University, Shanghai 200233, China. cqinqin@fm365.com
Zhou
Tong
T
Chen
Wei-Xiong
WX
Zhu
Jin-Shui
JS
Chen
Ni-Wei
NW
Zhang
Ming-Jun
MJ
Wu
Yun-Lin
YL
D000818:Animals; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000494:pharmacology*; D007668:Kidney / Q000473:pathology / Q000502:physiology; D008099:Liver / Q000473:pathology / Q000502:physiology; D008297:Male; D019007:P-Selectin / Q000378:metabolism*; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
D016166:Free Radical Scavengers; D019007:P-Selectin; D011719:Pyrazines; C017953:tetramethylpyrazine