Efficacy of dichloroacetate as a lactate-lowering drug.
Dichloroacetate (DCA) decreases blood, cerebral spinal fluid, and intracellular lactate concentrations by activating the mitochondrial pyruvate dehydrogenase enzyme complex. The authors reviewed the efficacy of this investigational drug in the treatment of acquired or congenital forms of lactic acidosis from data in 40 English-language publications. The hypolactatemic effect of DCA occurs over a broad range of pretreatment lactate concentrations and is directly related to the baseline lactate level. The maximum lactate-lowering effect of the drug is dependent on its dose but independent of time following its administration. Recent clinical studies of acquired lactic acidosis suggest that DCA could be rapidly effective in reducing this risk factor of mortality in patients with mild hyperlactatemeia.
Stacpoole
Peter W
PW
Department of Medicine (Division of Endocrinology and Metabolism), Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, USA.
Nagaraja
Nelamangala V
NV
Hutson
Alan D
AD
D000140:Acidosis, Lactic / Q000188:drug therapy* / Q000378:metabolism; D000284:Administration, Oral; D002986:Clinical Trials as Topic; D003999:Dichloroacetic Acid / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male
D003999:Dichloroacetic Acid