Nonlinear photodynamic therapy. Saturation of a photochemical dose by photosensitizer bleaching.
Photodynamic therapy with total photobleaching of a photosensitizer was studied theoretically. The possibilities of having constant therapeutic dose within a large extent of a tissue and even of obtaining the maximal dose at a particular depth were considered. The use of both surface irradiation or interstitial irradiation were evaluated.
Kogan
Boris Ya
BY
Organic Intermediates and Dyes Institute, B. Sadovaya str. 1/4, 123995 Moscow, Russia. kogan@dic.ru
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007700:Kinetics; D038761:Photobleaching; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000493:pharmacokinetics* / Q000627:therapeutic use
D017319:Photosensitizing Agents