Regulation of quiescence in lymphocytes.
Cellular quiescence is a state characterized by decreased cell size and metabolic activity. In quiescent nai;ve lymphocytes, antigen recognition with appropriate co-stimulation triggers exit from G0 phase of the cell cycle, increased size and metabolism and progression through the cell cycle. Recent studies have shown that quiescence in lymphocytes is an actively maintained state rather than a default pathway in the absence of signal. Certain transcription factors appear to act as master regulators of gene expression patterns that enforce the quiescent phenotype. Here, we discuss candidate lymphocyte quiescence factors and their potential target genes and mechanisms of action.
Yusuf
Isharat
I
Department of Molecular Biology and Biochemistry, 3242 McGaugh Hall, University of California, Irvine, CA 92697-3900, USA.
Fruman
David A
DA
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000276:immunology; D002454:Cell Differentiation; D015870:Gene Expression; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D051741:Kruppel-Like Transcription Factors; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D018448:Models, Immunological; D010641:Phenotype; D016192:Resting Phase, Cell Cycle / Q000276:immunology*; D015534:Trans-Activators / Q000235:genetics / Q000276:immunology; D025521:Tumor Suppressor Proteins
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C096161:KLF2 protein, human; D051741:Kruppel-Like Transcription Factors; C098669:TOB1 protein, human; D015534:Trans-Activators; D025521:Tumor Suppressor Proteins