title: Regression of fibrosis in chronic hepatitis C after therapy with interferon and ribavirin.
abstract: Interferon and ribavirin decrease necroinflammation in chronic hepatitis C with or without virological clearance; however, reversibility of fibrosis remains to be established. We evaluated the effect of combination therapy on virological and liver histopathological outcomes in 52 naive patients and 79 patients unresponsive to interferon monotherapy with predominantly genotype 1 chronic hepatitis C. One hundred four patients completed interferon and ribavirin treatment after 24-48 weeks. Fifty-six paired liver biopsies (mean biopsy interval 28 months) were assessed by the Ishak score. Sustained virological responses were 37% in naive patients and 22% in re-treated patients. In virological responders and nonresponders, fibrosis and necroinflammation scores decreased by -0.91 (P = 0.04) and -0.5 (P = 0.02) and by -2.8 (P = 0.001) and -0.66 (P = 0.06), respectively. Interferon and ribavirin had greater benefit on fibrosis when associated with clearance of HCV RNA. Treatment strategies in virological nonresponders who show fibrosis regression should include consideration of maintenance therapy, if such treatment eventually proves to benefit histological outcomes.
authors.affiliation: Department of Medicine, Division of Gastroenterology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA.
authors.forename: Asma
authors.initials: A
authors.lastname: Arif
authors.forename: Robert A
authors.initials: RA
authors.lastname: Levine
authors.forename: Schuyler O
authors.initials: SO
authors.lastname: Sanderson
authors.forename: Leslie
authors.initials: L
authors.lastname: Bank
authors.forename: Raja P
authors.initials: RP
authors.lastname: Velu
authors.forename: Ashok
authors.initials: A
authors.lastname: Shah
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Mahl
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Gregory
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use*; D008103:Liver Cirrhosis / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012074:Remission Induction; D012254:Ribavirin / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D012254:Ribavirin; D007372:Interferons