title: Functional dyspepsia: evaluation and treatment.
abstract: Functional dyspepsia is one of the most common disorders seen in general practice and by gastroenterologists. New concepts regarding the pathophysiology and its role for the symptom pattern have emerged during the last few years. This is of importance for development of new treatment alternatives in the near future. At the moment, however, empirical treatment with acid-suppressive agents and prokinetics is the recommended therapeutic approach in the management of these patients, despite limited efficacy. Identification and treatment of H pylori infection has been recommended for uninvestigated dyspepsia, because it may cure underlying peptic ulcer disease, but is unlikely to provide symptomatic benefit to patients with functional dyspepsia. Refractory patients may respond to antidepressants or to psychologic treatments, but proof of efficacy is limited. New and more effective approaches are badly needed for functional dyspepsia.
authors.affiliation: Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Herestraat 49, B-3000, Leuven, Belgium.
authors.forename: Magnus
authors.initials: M
authors.lastname: Simrén
authors.forename: Jan
authors.initials: J
authors.lastname: Tack
mesh_terms: D015746:Abdominal Pain / Q000209:etiology / Q000503:physiopathology; D001341:Autonomic Nervous System / Q000503:physiopathology; D002490:Central Nervous System / Q000503:physiopathology; D004359:Drug Therapy, Combination; D004415:Dyspepsia / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology*; D011613:Psychotherapy