New building blocks for the assembly of sequence selective molecular zippers.
Synthetic H-bonded molecular zippers contain no sequence information that can be used to engineer the selective binding interactions characteristic of biopolymers; reversing the sense of the amide bonds in the two binding partners generates a new orthogonal recognition motif and the mutually complementary binding partners form complexes an order of magnitude more stable than the corresponding mismatch complexes.
Hunter
Christopher A
CA
Centre for Chemical Biology, Krebs Institute for Biomolecular Science, Department of Chemistry, University of Sheffield, Sheffield, UK S3 7HF.
Jones
Philip S
PS
Tiger
Pascale M N
PM
Tomas
Salvador
S
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001665:Binding Sites; D001704:Biopolymers / Q000737:chemistry*; D006860:Hydrogen Bonding; D046911:Macromolecular Substances; D015394:Molecular Structure; D015202:Protein Engineering / Q000379:methods*
D001704:Biopolymers; D046911:Macromolecular Substances