Language lateralization in patients with temporal lobe epilepsy: a comparison of functional transcranial Doppler sonography and the Wada test.
This study prospectively investigates whether noninvasive functional transcranial Doppler sonography (fTCD) is a useful tool to determine hemispheric language lateralization in the presurgical evaluation of patients with medically intractable temporal lobe epilepsy (TLE). fTCD results were compared with the Wada test as the gold standard. Wada test and fTCD were performed in 13 patients suffering from TLE. fTCD continuously measured blood flow velocities in both middle cerebral arteries, while the patient was performing a cued word generation task. During the Wada test, spontaneous speech, comprehension, reading, naming, and repetition were investigated. A laterality index (LI) was obtained by both procedures. Due to a lack of an acoustic temporal bone window, fTCD could not be performed in two patients (15%). In 9 of the remaining 11 patients hemispheric language dominance was found on the left side, in 1 patient on the right side, and 1 patient showed bihemispheric language representation. In all patients fTCD and the Wada test were in good agreement regarding hemispheric language lateralization, and the LI of both techniques were highly correlated (r = 0.776, P = 0.005). fTCD gives predictions of hemispheric language dominance consistent with the Wada test results even in children, patients with low IQ, and nonnative speakers. It is an alternative to the Wada test in determining language lateralization in patients with temporal lobe epilepsy.
Knake
Susanne
S
Department of Neurology, Interdisciplinary Epilepsy Center, Philipps-University, Marburg, Germany. susanne@nmr.mgh.harvard.edu
Haag
Anja
A
Hamer
Hajo M
HM
Dittmer
Christine
C
Bien
Siegfried
S
Oertel
Wolfgang H
WH
Rosenow
Felix
F
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D000654:Amobarbital / Q000008:administration & dosage; D002339:Carotid Arteries; D002648:Child; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007269:Injections, Intra-Arterial; D007802:Language; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D019635:Neurosurgical Procedures; D011446:Prospective Studies; D017585:Ultrasonography, Doppler, Transcranial
D006993:Hypnotics and Sedatives; D000654:Amobarbital