Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine.
A novel C2-aryl 1,2-unsaturated PBD (14) has been prepared via an enol triflate intermediate (8). The regiochemistry of triflation is dependent upon the point at which the reaction is performed during the synthetic route.
Kang
Gyoung-Dong
GD
Cancer Research UK Gene Targeted Drug Design Research Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London, UK WC1N 1AX.
Howard
Philip W
PW
Thurston
David E
DE
D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D001569:Benzodiazepines / Q000138:chemical synthesis*; D011758:Pyrroles / Q000138:chemical synthesis*; D013302:Streptomyces / Q000737:chemistry
D000903:Antibiotics, Antineoplastic; D011758:Pyrroles; C438462:pyrrolo(2,1-c)(1,4)benzodiazepine; D001569:Benzodiazepines