Hypoxia-induced dedifferentiation in neuroblastoma cells.
Hypoxia in solid tumors is associated with aggressive behavior and poor outcome. We recently discovered that hypoxia alters the expression of differentiation marker genes in neuroblastoma cells, in that the tumor cells adjust to the hypoxic environment by down-regulating genes associated with a neuronal and upregulating genes associated with a neural crest-like phenotype. As there is a correlation in neuroblastoma between low stage of differentiation and high (aggressive) clinical stage, we propose that dedifferentiation of neuroblastoma cells in hypoxic tumor regions contribute to the malignancy of the tumor.
Jögi
Annika
A
Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, University Hospital MAS, S-205 02 Malmö, Sweden.
Øra
Ingrid
I
Nilsson
Helen
H
Poellinger
Lorenz
L
Axelson
Håkan
H
Påhlman
Sven
S
D002454:Cell Differentiation; D015687:Cell Hypoxia; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009447:Neuroblastoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D013564:Sympathetic Nervous System / Q000378:metabolism; D014157:Transcription Factors; D014407:Tumor Cells, Cultured
C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D014157:Transcription Factors