title: Electrostimulation: a future treatment option for patients with neurogenic urodynamic disorders?
abstract: This paper provides an overview of electrical stimulation of the nervous system as a treatment option for urodynamic dysfunction and of some of the recent results in this field. The set-up used in our studies for improved bladder filling in spinal cord injured patients by conditional stimulation of the dorsal penile/clitoral nerve is a highly efficient way to limit neurogenic detrusor overactivity and increase bladder capacity. Ongoing studies suggest that recording of bladder nerve activity is stable over time and may be a technique for chronic monitoring of bladder activity. Bladder emptying exploiting an anodal blocking technique permits bladder emptying without simultaneous urethral-perineal contraction, thus enabling a physiological voiding pattern in one continuous sequence. In patients with supraspinal lesions, deep brain electrical stimulation is established only as treatment for a subgroup of patients suffering from Parkinson's disease. Yet, with improved electrode designs and increased clinical experience and experimental results, probably other groups of patients may be candidates for deep brain stimulation. In our study in pigs there was a trend towards increased bladder capacity and compliance in response to stimulation, which is encouraging as several neurological diseases are accompanied by overactive bladder with reduced capacity.
authors.affiliation: Institute of Experimental Clinical Research, University of Aarhus, Arhus, Denmark. asger.dalmose@dadlnet.dk
authors.forename: Asger
authors.initials: A
authors.lastname: Dalmose
authors.forename: Carsten
authors.initials: C
authors.lastname: Bjarkam
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Vuckovic
authors.forename: Jens Christian
authors.initials: JC
authors.lastname: Sørensen
authors.forename: John
authors.initials: J
authors.lastname: Hansen
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000502:physiology; D004597:Electroshock / Q000295:instrumentation; D006801:Humans; D008297:Male; D017933:Peripheral Nervous System / Q000502:physiology; D013552:Swine; D001750:Urinary Bladder, Neurogenic / Q000628:therapy*