Cardiopulmonary bypass is not associated with increased jugular venous blood free radical activity.
We have measured jugular venous oxygen saturation (sjv(O2)) and lactate, arterial and jugular venous blood levels of lipid peroxidation products--malondialdehyde (MDA) and diene conjugates as an index of free radical activity in eight adults undergoing coronary artery bypass surgery. Measurements were carried out at six specific times: T1--within 5 min before cardiopulmonary bypass (CPB), T2--within the first minute after the commencement of CPB, T3--during stable temperature (28 degrees C) on CPB, T4--during rewarming at 34 degrees C, T5--15 min after CPB and T6--at skin closure. There were no significant changes in arterial, jugular venous and arterio-jugular venous (a-jv) differences in diene conjugates and MDA. There was no correlation between sjv(O2), lactate and a-jv differences in MDA and diene conjugates. These results are not indicative of ischaemia-reperfusion injury across the cerebral circulation during hypothermic CPB.
Ip-Yam
P C
PC
University Department of Anaesthesia, Royal Liverpool University Hospital, Liverpool UK.
Browning
P G
PG
Behl
S
S
D000466:Alkadienes / Q000097:blood; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002560:Cerebrovascular Circulation; D005609:Free Radicals / Q000097:blood*; D006801:Humans; D007036:Hypothermia, Induced; D007601:Jugular Veins; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D015427:Reperfusion Injury / Q000209:etiology; D013997:Time Factors
D000466:Alkadienes; D005609:Free Radicals; D008315:Malondialdehyde