title: Genomic strategies for diabetic nephropathy.
abstract: Insight into the molecular mechanisms that underlie the origin and progression of diabetic nephropathy remains limited in part because conventional research tools have restricted investigators to focus on single genes or isolated pathways. Microarray technologies provide opportunities for evaluating genetic factors and environmental effects at a genomic scale during the pathogenesis of diabetic nephropathy. Despite the enormous power of the microarray technology, there are several pitfalls that need to be considered. This article discusses conceptual, practical, statistical, and logistical considerations for the use of microarrays in studies of experimental and human diabetic renal disease. New knowledge in this field will facilitate new approaches for molecular diagnosis and drug discovery.
authors.affiliation: Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA. ksusztak@aecom.yu.edu
authors.forename: Katalin
authors.initials: K
authors.lastname: Susztak
authors.forename: Kumar
authors.initials: K
authors.lastname: Sharma
authors.forename: Mario
authors.initials: M
authors.lastname: Schiffer
authors.forename: Peter
authors.initials: P
authors.lastname: McCue
authors.forename: Emilio
authors.initials: E
authors.lastname: Ciccone
authors.forename: Erwin P
authors.initials: EP
authors.lastname: Böttinger
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000235:genetics; D003928:Diabetic Nephropathies / Q000235:genetics*; D015894:Genome, Human; D023281:Genomics / Q000379:methods; D006801:Humans; D007668:Kidney / Q000503:physiopathology