[Oxidative stress].
Oxidative stress, which is enhanced in diabetes mellitus, causes hypertension and plays a critical role on cardiovascular damages in diabetes and hypertension. Angiotensin II is one of important intrinsic oxidants in pathophysiology of hypertension. Reactive oxygen species affect hypertension and its complications via inactivation of nitric oxide, modification of lipid metabolism, and enhanced insulin resistance. Moreover, oxidative stress and hypertension accelerate cardiovascular damages. Thus, it is important to control oxidative stress in hypertensive patients with diabetes.
Ando
Katsuyuki
K
Health Service Center, University of Tokyo.
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007333:Insulin Resistance; D050356:Lipid Metabolism; D009569:Nitric Oxide / Q000378:metabolism; D016877:Oxidants / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species
D016877:Oxidants; D017382:Reactive Oxygen Species; D000804:Angiotensin II; D009569:Nitric Oxide