title: [Drug sensitivity of Helicobacter pylori strains in children and young people from the region of Łódź].
abstract: Combined therapy with a proton pump inhibitor and two antibiotics (metronidazole, clarithromycin and amoxicillin or tetracycline) is applied in the treatment of H. pylori infection. The effects of the treatment depend on drug sensitivity of H. pylori. Growing resistance to some of the applied antibiotics has been observed. The aim of the study was to assess drug sensitivity of Helicobacter pylori strains which were isolated from the gastric mucosa of children and young people living in the macroregion of Łódź. The study comprised 45 children aged between 5 and 18 years. Biopsy specimens were put on transport medium, incubated in microaerophilic environment, then identified. Drug sensitivity to metronidazole, clarithromycin, amoxicillin and tetracycline was assessed. We found resistance to metronidazole in 18% (8/45) children, resistance to clarithromycin in 16% (7/45) children and resistance to both antibiotics in 4% (2/45) children. No resistance to amoxicillin or tetracycline was noted.
authors.affiliation: I Klinika Pediatrii i Gastroenterologii, Instytut Centrum Zdrowia Matki Polki, ul. Rzgowska 272, 93-338 Lodz, Poland. kpgiczmp@mazurek.man.lodz.pl
authors.forename: Leokadia
authors.initials: L
authors.lastname: Bak-Romaniszyn
authors.forename: Izabela
authors.initials: I
authors.lastname: Planeta-Malecka
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Czkwianianc
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Rozynek
authors.forename: Danuta
authors.initials: D
authors.lastname: Dzierzanowska
authors.forename: Wiktor
authors.initials: W
authors.lastname: Laszewicz
mesh_terms: D000293:Adolescent; D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D017291:Clarithromycin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D004359:Drug Therapy, Combination; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011044:Poland; D012307:Risk Factors; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D000658:Amoxicillin; D013752:Tetracycline; D017291:Clarithromycin