Fluconazole in combination with flucytosine in the treatment of fluconazole-resistant Candida infections.
Two patients with renal failure and fluconazole resistant but flucytosine susceptible Candida deep infection were successfully treated with the combination of the two drugs. In vitro susceptibility, determined by microdilution and time-kill methods, and fungostatic activity of the serum showed an additive interaction of fluconazole and flucytosine. In the event of infections by Candida isolates resistant to fluconazole but susceptible to 5-fluorocytosine, the combination of these drugs may be a possible therapeutic choice.
Girmenia
Corrado
C
Dipartimento di Biotecnologie Cellulari ed Ematologia, University "La Sapienza", Rome, Italy. girmenia@bce.uniromal.it
Venditti
Mario
M
Martino
Pietro
P
D000935:Antifungal Agents / Q000627:therapeutic use*; D002175:Candida / Q000145:classification / Q000302:isolation & purification; D002177:Candidiasis / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D002648:Child; D025141:Drug Resistance, Fungal; D004359:Drug Therapy, Combination; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D005437:Flucytosine / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000935:Antifungal Agents; D015725:Fluconazole; D005437:Flucytosine