[Effect of sympathectomy on the heart pump function in rats during postnatal ontogenesis].
The influence of guanetidine sympathectomy (30 mg/kg) on the heart pump function in rats during 3 weeks in postnatal ontogenesis has been investigated. Sympathectomy restrains age-dependent establishment of stroke volume, cardiac output and heart rate. The adaptation effects of regular physical training do not develop in the animals with sympathectomy, i.e. heart rate does not decrease and stroke volume does not increase. The initial stage of adaptation of the sympathectomized animals to physical training is accompanied by decrease in stroke volume and remarkable increase in heart rate which indicates the reduction of contractile activity in the myocardium.
Nigmatullina
R R
RR
Kazan State Medical University, 420012, Kazan, 49 Butlerov St., Russia.
Khuramshin
I G
IG
Nasyrova
A G
AG
D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D001810:Blood Volume / Q000502:physiology; D003326:Coronary Circulation / Q000502:physiology*; D006145:Guanethidine; D006321:Heart / Q000254:growth & development / Q000294:innervation / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D051381:Rats; D013318:Stroke Volume / Q000502:physiology; D013563:Sympathectomy, Chemical
D006145:Guanethidine