Patched 1 conditional null allele in mice.
The patched gene (Ptc) is a member of the hedgehog signaling pathway which plays a central role in the development of many invertebrate and vertebrate tissues. In addition, Ptc and a number of other pathway members are mutated in some common human cancers. Patched is the receptor for the hedgehog ligand and in the mouse ablation of the Ptc gene leads to developmental defects and an embryonic lethal phenotype. Here we describe a conditional Ptc allele in mice which will have utility for the temporospatial ablation of Ptc function.
Ellis
Tammy
T
Institute for Molecular Bioscience, University of Queensland, Brisbane Queensland, Australia.
Smyth
Ian
I
Riley
Emily
E
Graham
Scott
S
Elliot
Kate
K
Narang
Monica
M
Kay
Graham F
GF
Wicking
Carol
C
Wainwright
Brandon
B
D000483:Alleles; D000818:Animals; D015139:Blotting, Southern; D017931:DNA Primers; D020868:Gene Silencing; D018390:Gene Targeting; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000172:deficiency* / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011956:Receptors, Cell Surface
D017931:DNA Primers; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C000606236:PTCH1 protein, human; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; C000606240:Ptch1 protein, mouse; D011956:Receptors, Cell Surface