Preparation of radioactively labeled dehydroxymethyl-epoxyquinomicin, an NF-kappa B function inhibitor.
Dehydroxymethylepoxyquinomicin (DHMEQ), a synthetic derivative of epoxyquinomicin C, is a potent and specific inhibitor of NF-kappa B in cultured cells. Tritium-labeled DHMEQ was synthesized with sodium borotritium. Specific radioactivity of the synthesized tritium-labeled DHMEQ was 15.45 mCi/mmol. This compound would be for the study of the mechanism of action and the stability of DHMEQ.
Chaicharoenpong
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C
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-0061, Japan.
Kato
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K
Umezawa
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D001549:Benzamides / Q000737:chemistry*; D003512:Cyclohexanones / Q000737:chemistry*; D007553:Isotope Labeling; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D014316:Tritium
D001549:Benzamides; D003512:Cyclohexanones; D016328:NF-kappa B; C464444:dehydroxymethylepoxyquinomicin; D014316:Tritium