title: Why thrombin generation? From bench to bedside.
abstract: Intervention for clotting and bleeding disorders is costly, and clear-cut regimens undefined. The margin of safety between hemostasis and thrombosis is narrow and unpredictable. The use of a laboratory test to help define therapeutic regimens, dissect effects of these treatments, and to differentiate them are clearly needed. The current state of the art of thrombin generation is ready to do this.
authors.affiliation: Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029-6574, USA. louis.aledort@mssm.edu
authors.forename: Louis M
authors.initials: LM
authors.lastname: Aledort
mesh_terms: D001778:Blood Coagulation Disorders / Q000097:blood / Q000175:diagnosis / Q000235:genetics; D001780:Blood Coagulation Tests / Q000379:methods*; D006487:Hemostasis; D006801:Humans; D019095:Point-of-Care Systems; D013917:Thrombin / Q000096:biosynthesis*
chemical_list: D013917:Thrombin