Trace elements improve survival of DTIC-treated mice with overt liver metastases of Lewis lung carcinoma.
Trace elements have been previously shown to have specific antimetastatic effects in a mouse 3LLHH liver metastasis model. Here we have analyzed the effect on the survival of animals with liver metastases. Trace elements administered per os at 500-5000 mg/kg/day did not affect the survival of animals with liver metastases. However, when trace element treatment was combined with dacarbazine (DTIC) administration, the survival of animals was significantly improved (55%). This effect was specific for DTIC since trace elements did not influence the effect of 5-fluorouracil on survival in this liver metastasis model. These data and those found in the literature all suggest that trace elements can specifically modulate the antitumoral/antimetastatic effects of chemotherapeutic agents.
Rásó
Erzsébet
E
National Institute of Oncology, Budapest, Hungary.
Paku
Sándor
S
Kopper
László
L
Tímár
József
J
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000401:mortality* / Q000556:secondary; D003606:Dacarbazine / Q000627:therapeutic use*; D005472:Fluorouracil / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000556:secondary; D051379:Mice; D015996:Survival Rate; D014131:Trace Elements / Q000008:administration & dosage*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D014131:Trace Elements; D003606:Dacarbazine; D005472:Fluorouracil