[Analysis of genetic diversity of the mitochondrial DNA in the forensic medical expert identification of individuals].
Spectra of haplotype frequencies were studied for locuses of hypervariable segments 1 and 2 (HVS1 and HVS2), separately for each, and for linked segment HVS1-HVS2. The obtained data were used to determine the values and to evaluate comparatively the discriminating characteristics of the corresponding individualizing systems based on the typing of mtDNA. The system of typing, based on HVS2 (mv = 0.098), was found to possess the least discriminating potential; while the highest information rate is ensured in the analysis of HVS1 (m omega = 0.02) and in the joint analysis of HVS1 and HVS2 (mw = 0.007). The frequency rates of the key haplogroups were estimated within a random sampling of Russian citizens. A random population sampling of Russian citizens was shown not to differ essentially from an ethnically homogeneous population sampling of Russians selected with regard for a genetic diversity and for a spectrum of mitochondrial lines. The results point at the most rational algorithm of examinations in a forensic expert's analysis of mtDNA. The studied sampling can trigger the development of a referential data base designed for conducting, in the Russian Federation, the forensic-medical expert's examinations based on the mtDNA typing.
Ivanov
P L
PL
Orekhov
V A
VA
Frolova
S A
SA
Zemskova
E Iu
EIu
Solov'eva
N O
NO
Bin'ko
I A
IA
D004272:DNA, Mitochondrial / Q000032:analysis*; D005787:Gene Frequency / Q000235:genetics*; D005828:Genetics, Population; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic; D012426:Russia
D004272:DNA, Mitochondrial