title: Allopurinol challenge tests performed before and after living-related donor liver transplantation in citrullinaemia.
abstract: We performed allopurinol challenge tests to evaluate the metabolic state of a citrullinaemic patient who received a living-relative donor liver transplant. Before transplantation, large amounts of orotic acid and orotidine were excreted during the challenge test. Following transplantation, excretion of these compounds in response to allopurinol was normalised. The challenge test was a safe and useful method to evaluate the metabolic state of the patient.
authors.affiliation: Department of Pediatrics, Nagoya City University Medical School, Nagoya, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Sumi
authors.forename: K
authors.initials: K
authors.lastname: Kidouchi
authors.forename: K
authors.initials: K
authors.lastname: Ban
authors.forename: A
authors.initials: A
authors.lastname: Ueta
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Togari
authors.forename: Y
authors.initials: Y
authors.lastname: Wada
mesh_terms: D000493:Allopurinol; D000963:Antimetabolites; D002648:Child; D002851:Chromatography, High Pressure Liquid; D002956:Citrulline / Q000097:blood*; D020159:Citrullinemia / Q000175:diagnosis* / Q000601:surgery*; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000502:physiology*; D019520:Living Donors
chemical_list: D000963:Antimetabolites; D002956:Citrulline; D000493:Allopurinol