title: Synthesis and in vitro antitumor activity of phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine: structure-activity relationship.
abstract: A series of substituted pyrido[4,3,2-de][1,7] or [1,10]-phenanthrolin-7-ones, analogues of the marine pyridoacridines meridine and ascididemin, have been synthesized on the basis of Diels-Alder reactions involving different quinoline-5,8-diones and N,N-aldehyde-dimethylhydrazones. All the compounds were evaluated for in vitro cytotoxic activity against 12 distinct human cancer cell lines. They all exhibit cytotoxic activity with IC(50) values at least of micromolar order.
authors.affiliation: Centre de Phytopharmacie, UMR-CNRS 5054, Université de Perpignan, 52 Avenue de Villeneuve, 66860 Perpignan Cedex, France. delfourn@univ.perp.fr
authors.forename: Evelyne
authors.initials: E
authors.lastname: Delfourne
authors.forename: Robert
authors.initials: R
authors.lastname: Kiss
authors.forename: Laurent
authors.initials: L
authors.lastname: Le Corre
authors.forename: Frederic
authors.initials: F
authors.lastname: Dujols
authors.forename: Jean
authors.initials: J
authors.lastname: Bastide
authors.forename: Françoise
authors.initials: F
authors.lastname: Collignon
authors.forename: Brigitte
authors.initials: B
authors.lastname: Lesur
authors.forename: Armand
authors.initials: A
authors.lastname: Frydman
authors.forename: Francis
authors.initials: F
authors.lastname: Darro
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006835:Hydrazones / Q000737:chemistry; D010618:Phenanthrolines; D011804:Quinolines / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D006835:Hydrazones; D010618:Phenanthrolines; D011804:Quinolines; C079196:meridine; C412046:ascididemin