title: Antiplatelet activity of benzylisoquinoline derivatives oxidized by cerium(IV) ammonium nitrate.
abstract: Oxidation of 1-benzyl-3,4-dihydroisoquinolines with cerium(IV) ammonium nitrate (CAN) under mild condition yielded the mixture of corresponding 1-benzylisoquinolines (b-type) and 1-benzoylisoquinolines (a- or c-type) in an equal yields. The selective oxidation products (c-type) can be prepared by using MeCN instead of MeOH. In the antiplatelet assays, four inducers were employed, including AA, Col, PAF, and Thr. In the PAF or Col induced platelet aggregation, compounds belonging to a- and b-type showed stronger inhibitory effects than aspirin.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Reen-Yen
authors.initials: RY
authors.lastname: Kuo
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Chin-Chun
authors.initials: CC
authors.lastname: Wu
authors.forename: Ramesh
authors.initials: R
authors.lastname: Patnam
authors.forename: Wei-Ya
authors.initials: WY
authors.lastname: Wang
authors.forename: Ying-Chi
authors.initials: YC
authors.lastname: Du
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D016718:Arachidonic Acid / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D044182:Benzylisoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D002563:Cerium / Q000737:chemistry*; D003094:Collagen / Q000494:pharmacology; D009566:Nitrates / Q000737:chemistry*; D010084:Oxidation-Reduction; D010972:Platelet Activating Factor / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000494:pharmacology
chemical_list: D044182:Benzylisoquinolines; D009566:Nitrates; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; D002563:Cerium; D003094:Collagen; D013917:Thrombin; D001241:Aspirin; C006568:ammonium nitrate