[Study on the targeting of nanoparticles loading TK gene in mice].
The tissue distribution of DNA-PLGA-NP was investigated by the technique of gamma scintigraphy. The results showed that 30 min after mouse caudal vein injection of 32P-DNA-PLGA-NP, the ratio of radioactivity in liver against total radioactivity is higher than 70%, which is 1.4 fold the ratio after caudal vein injection of 32P-DNA, and that 2 h after subcutaneous injection of 32P-DNA-PLGA-NP 2 h, the ratio of the radioactivity in liver against total radioactivity is also higher than 70%, reaching a 1.6 fold increase when compared with the ratio after subcutaneous injection of 32P-DNA.
He
Qin
Q
School of Pharmacy, Sichuan University, Chengdu 610041.
Liu
Ji
J
Zhang
Zhirong
Z
Zhang
Min
M
Tu
Li
L
D000818:Animals; D004247:DNA / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004337:Drug Carriers; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D019344:Lactic Acid; D051379:Mice; D010316:Particle Size; D010957:Plasmids / Q000008:administration & dosage / Q000235:genetics / Q000493:pharmacokinetics*; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D013937:Thymidine Kinase / Q000235:genetics*; D014018:Tissue Distribution
D004337:Drug Carriers; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D004247:DNA; D013937:Thymidine Kinase