Slice-selective J-coupled coherence transfer using symmetric linear phase pulses: applications to localized GABA spectroscopy.
Symmetric, linear phase, slice-selective RF pulses were analyzed theoretically for performing slice-selective coherence transfer. It was shown using numerical simulations of product operators that, when a prefocusing gradient of the same area as that of the refocusing gradient is added, these pulses become slice-selective universal rotator pulses, therefore, capable of performing slice-selective coherence transfer. As an example, a slice-selective universal rotator pulse based on a seven-lobe hamming-filtered sinc pulse was applied to in vivo single-shot simultaneous spectral editing and spatial localization of neurotransmitter GABA in the human brain.
Shen
Jun
J
Molecular Imaging Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, 9000 Rockville Pike, MSC 1527, Bethesda, MD 20892-1527, USA. shenj@intra.nimh.nih.gov
D000465:Algorithms; D001923:Brain Chemistry; D003198:Computer Simulation; D004735:Energy Transfer; D016014:Linear Models; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008280:Magnetics; D008956:Models, Chemical; D008958:Models, Molecular; D011846:Radio Waves; D012815:Signal Processing, Computer-Assisted; D005680:gamma-Aminobutyric Acid / Q000032:analysis* / Q000737:chemistry*
D005680:gamma-Aminobutyric Acid