title: Pathophysiology of endothelin and medical emergencies.
abstract: Pathophysiology of endothelin-1, a vasoconstrictor and a mitogenic peptide, has been extensively investigated in recent years. The authors have examined the main clinical and experimental evidence regarding the involvement of this peptide in some medical emergencies, namely myocardial infarction, stroke and hepato-renal syndrome. Literature data suggest an emerging pathophysiological role for endothelin in such clinical conditions.
authors.affiliation: Department of Internal Medicine and Systemic Diseases, University of Catania, Catania, Italy.
authors.forename: C M
authors.initials: CM
authors.lastname: Bruno
authors.forename: S
authors.initials: S
authors.lastname: Neri
authors.forename: P
authors.initials: P
authors.lastname: Di Prima
authors.forename: C
authors.initials: C
authors.lastname: Sciacca
mesh_terms: D004630:Emergencies; D019332:Endothelin-1 / Q000378:metabolism*; D006530:Hepatorenal Syndrome / Q000503:physiopathology*; D006801:Humans; D009203:Myocardial Infarction / Q000503:physiopathology*; D020521:Stroke / Q000503:physiopathology*
chemical_list: D019332:Endothelin-1