Evidence for an antihyperalgesic effect of venlafaxine in vincristine-induced neuropathy in rat.
Venlafaxine, a new antidepressant with fewer side effects, could be of interest to reduce neuropathic pain following antineoplasic drug treatment. In the present study, we demonstrated that venlafaxine inhibits hyperalgesia in a new rat model of neuropathy induced by the antineoplasic drug vincristine, and exerts its effect preferentially via supraspinal and spinal mechanisms.
Marchand
Fabien
F
Laboratoire de Pharmacologie Médicale, Faculté de Médecine, E 9904 INSERM/UdA, 63001 Clermont-Ferrand Cedex 1, France.
Alloui
Abdelkrim
A
Pelissier
Teresa
T
Hernández
Alejandro
A
Authier
Nicolas
N
Alvarez
Pedro
P
Eschalier
Alain
A
Ardid
Denis
D
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D003511:Cyclohexanols / Q000494:pharmacology*; D004195:Disease Models, Animal; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009437:Neuralgia / Q000139:chemically induced* / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D000069470:Venlafaxine Hydrochloride; D014750:Vincristine / Q000009:adverse effects*
D000700:Analgesics; D018687:Antidepressive Agents, Second-Generation; D000972:Antineoplastic Agents, Phytogenic; D003511:Cyclohexanols; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride; D014750:Vincristine