title: Are 5'-O-carbamate-2',3'-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs?
abstract: In contrast to 5'-O-carbonate 3TC derivatives (23, 24), which are clearly 3TC prodrugs, the corresponding 3TC carbamates (15-21 and 25), found to be very stable compounds with respect to enzymatic hydrolysis (cellular lysates and culture cell media) and still active on both HIV-1 and HBV infected cells, may not be 3TC prodrugs. The antiviral properties as well as the mechanism of action of 3TC analogues have been studied and evaluated.
authors.affiliation: Laboratoire de Chimie Biomoléculaire, INSERM U-382, IBDM, Université Méditerranée, Parc Scientifique de Luminy, 163 avenue de Luminy, case 901, 13288 Marseille Cedex 9, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Anastasi
authors.forename: Patrick
authors.initials: P
authors.lastname: Vlieghe
authors.forename: Olivier
authors.initials: O
authors.lastname: Hantz
authors.forename: Olivier
authors.initials: O
authors.lastname: Schorr
authors.forename: Christophe
authors.initials: C
authors.lastname: Pannecouque
authors.forename: Myriam
authors.initials: M
authors.lastname: Witvrouw
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Pascal
authors.initials: P
authors.lastname: Clayette
authors.forename: Nathalie
authors.initials: N
authors.lastname: Dereuddre-Bosquet
authors.forename: Dominique
authors.initials: D
authors.lastname: Dormont
authors.forename: Françoise
authors.initials: F
authors.lastname: Gondois-Rey
authors.forename: Ivan
authors.initials: I
authors.lastname: Hirsch
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Kraus
mesh_terms: D019380:Anti-HIV Agents / Q000378:metabolism / Q000494:pharmacology*; D000998:Antiviral Agents / Q000378:metabolism / Q000494:pharmacology*; D002460:Cell Line; D003470:Culture Media; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D011355:Prodrugs / Q000378:metabolism / Q000494:pharmacology*
chemical_list: C482460:5'-O-carbamate-2',3'-dideoxythiacytidine; D019380:Anti-HIV Agents; D000998:Antiviral Agents; D003470:Culture Media; D011355:Prodrugs; D003841:Deoxycytidine