title: Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine.
abstract: A novel C2-aryl 1,2-unsaturated PBD (14) has been prepared via an enol triflate intermediate (8). The regiochemistry of triflation is dependent upon the point at which the reaction is performed during the synthetic route.
authors.affiliation: Cancer Research UK Gene Targeted Drug Design Research Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London, UK WC1N 1AX.
authors.forename: Gyoung-Dong
authors.initials: GD
authors.lastname: Kang
authors.forename: Philip W
authors.initials: PW
authors.lastname: Howard
authors.forename: David E
authors.initials: DE
authors.lastname: Thurston
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D001569:Benzodiazepines / Q000138:chemical synthesis*; D011758:Pyrroles / Q000138:chemical synthesis*; D013302:Streptomyces / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D011758:Pyrroles; C438462:pyrrolo(2,1-c)(1,4)benzodiazepine; D001569:Benzodiazepines