Oral contraceptives use and the risk of myocardial infarction: a meta-analysis.
This meta-analysis of oral contraceptive use in relation to myocardial infarction is based on 19 case-control studies and 4 cohort studies that met pre-stated inclusion criteria. A comprehensive literature search was performed using the MEDLINE computerized database (for studies from January 1966 through October 2002). In addition, a manual search was performed for references cited in published original and reviewed articles. Current oral contraceptive (OC) users have an overall adjusted odds ratio (OR) of myocardial infarction (MI) of 2.48 [95% confidence interval (CI): 1.91-3.22] compared to never-users. The risk of MI for past OC users is not significantly different from that for never-users, overall OR = 1.15 (95% CI: 0.98-1.35; p = 0.096).
Khader
Yousef S
YS
Department of Biostatistics, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA. yousef.k@excite.com
Rice
Janet
J
John
Lefante
L
Abueita
Osama
O
D016022:Case-Control Studies; D015331:Cohort Studies; D003276:Contraceptives, Oral / Q000009:adverse effects*; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D009203:Myocardial Infarction / Q000139:chemically induced*; D016017:Odds Ratio; D012307:Risk Factors
D003276:Contraceptives, Oral; D004967:Estrogens