Factors influencing the development of lipodystrophy in human immunodeficiency virus-infected patients.
238 human immunodeficiency virus-infected patients on highly active antiretroviral therapy (HAART) were studied, 67 of whom (28.2%) developed lipodystrophy. The presence of hyperlipidaemia (p = 0.002) and of hepatitis C virus coinfection (p = 0.014) were associated with lipodystrophy, but only the duration of HAART was significantly predictive of lipodystrophy (p < 0.0001) in the multivariate analysis.
Collazos
Julio
J
Infectious Diseases Unit, Hospital de Galdácano, Vizcaya, Spain. jcollazos@hgda.osakidetza.net
Rodriguez-Guardado
Azucena
A
Maradona
Jose A
JA
Mayo
Jose
J
Asensi
Victor
V
Ibarra
Sofía
S
Carton
Jose A
JA
Casado
Luis
L
D000328:Adult; D017677:Age Distribution; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D015331:Cohort Studies; D015897:Comorbidity; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008060:Lipodystrophy / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011336:Probability; D012307:Risk Factors; D017678:Sex Distribution; D013030:Spain / Q000453:epidemiology; D013997:Time Factors