title: Glutathione.
abstract: Glutathione (GSH) is an ubiquitous thiol-containing tripeptide that plays a key role in cell biology. It modulates cell response to redox changes associated with the reactive oxygen species, detoxifies the metabolites of drugs; regulates gene expression and apoptosis, and is involved in the transmembrane transport of organic solutes. Polymorphism has been observed in key enzymes of GSH metabolism and some alleles have been associated with an impaired redox buffer system downsteam diseases, and susceptibility to ischaemia. These varied activities make GSH an attractive target for a more reductionist approach to the prevention and management of many conditions of interest to surgeons.
authors.affiliation: Department of Surgery, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia.
authors.forename: Heather
authors.initials: H
authors.lastname: Jefferies
authors.forename: Jane
authors.initials: J
authors.lastname: Coster
authors.forename: Alizan
authors.initials: A
authors.lastname: Khalil
authors.forename: Joan
authors.initials: J
authors.lastname: Bot
authors.forename: Rosalie D
authors.initials: RD
authors.lastname: McCauley
authors.forename: John C
authors.initials: JC
authors.lastname: Hall
mesh_terms: D005978:Glutathione / Q000737:chemistry / Q000502:physiology; D005979:Glutathione Peroxidase / Q000502:physiology; D005982:Glutathione Transferase / Q000502:physiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D010084:Oxidation-Reduction; D015427:Reperfusion Injury / Q000378:metabolism; D018805:Sepsis / Q000378:metabolism
chemical_list: D005979:Glutathione Peroxidase; D005982:Glutathione Transferase; D005978:Glutathione