title: Perceived health and physical functioning in postpoliomyelitis syndrome: a 6-year prospective follow-up study.
abstract: OBJECTIVE
  To study prospectively the health status, and especially the physical functioning, of polio survivors with and without postpoliomyelitis syndrome (PPS), and to identify prognostic determinants of change in physical functioning.
  
  
  METHODS
  Prospective cohort study; measurements at baseline and after 1, 2, and 6 years.
  
  
  METHODS
  University hospital in the Netherlands.
  
  
  METHODS
  Seventy-six subjects with PPS and 27 without PPS.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  The Nottingham Health Profile (NHP) physical mobility category.
  
  
  RESULTS
  Subjects with PPS had significantly poorer health status than subjects without PPS. No significant differences in mean NHP physical mobility scores between baseline and 6 years were found; both groups had improved after 1 year, after which there was a slow decline over the next 5 years. During the first 2 years, strength measurements showed little decline that was not related to changes in NHP physical mobility score. A physical performance test revealed no mean change in the first 2 years, but the subgroup with a decline above the 75th percentile eventually deteriorated 10.5+/-16.3 points on the NHP physical mobility category (P=.01) at 6 years from baseline. This subgroup had more extensive paresis than the other subjects, although it was not significant (P=.07). The extent of paresis at baseline was the only prognostic determinant for an increase in NHP physical mobility problems after 6 years.
  
  
  CONCLUSIONS
  Subjects with and without PPS did not differ with regard to changes in health status in a 6-year period. The fact that the extent of paresis was a prognostic factor for a decline in physical functioning is in accord with a (slow) decline in muscle mass, as a late effect of polio, that may lead to a decline in physical functioning as the reduced muscle capacity becomes less able to meet the demands of daily physical activities.
authors.affiliation: Department of Rehabilitation Medicine, University of Amsterdam, Amsterdam, The Netherland. f.nollet@amc.uva.nl
authors.forename: Frans
authors.initials: F
authors.lastname: Nollet
authors.forename: Anita
authors.initials: A
authors.lastname: Beelen
authors.forename: Jos W
authors.initials: JW
authors.lastname: Twisk
authors.forename: Gustaaf J
authors.initials: GJ
authors.lastname: Lankhorst
authors.forename: Marianne
authors.initials: M
authors.lastname: De Visser
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D001294:Attitude to Health; D016022:Case-Control Studies; D004185:Disability Evaluation; D005260:Female; D018737:Hand Strength; D006304:Health Status; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D010549:Personal Satisfaction; D016262:Postpoliomyelitis Syndrome / Q000503:physiopathology* / Q000523:psychology*; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D016059:Range of Motion, Articular; D012720:Severity of Illness Index; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D017741:Survivors / Q000523:psychology