title: Oral calcitriol: a new therapeutic agent in cutaneous lichen sclerosis.
abstract: BACKGROUND
  Lichen sclerosus remains an elusive disease with an uncertain relationship to morphea and scleroderma. The disorder has been difficult to treat, with no consistent and reproducible efficacious therapy. Recently, a beneficial effect of treatment with oral calcitriol (1-25 dihydroxyvitamin D3) in patients with scleroderma or morphea was described. This fact could be ascribed to the immunomodulatory effects of calcitriol observed in vitro and to inhibition of fibroblastic growth. Because of the success of calcitriol in localized scleroderma, we attempted this therapy in a patient with LS.
  
  
  METHODS
  One patient with cutaneous generalized LS resistant to different therapeutics was treated with calcitriol in an oral daily dose of 0.5 mcg. After 6 months of treatment, the skin extensibility increased, and the lesions improved. The improvement persisted after discontinuation of therapy during a follow-up period of one year. The only side effect was hypercalciuria, which resolved with dose reduction.
  
  
  CONCLUSIONS
  Calcitriol has shown a beneficial effect in scleroderma and morphea during open studies. A case is reported of a patient with LS who had a dramatic response to calcitriol. Double blind, placebo-controlled trials are needed to assess the therapeutic value of calcitriol in patients with LS.
authors.affiliation: Department of Dermatology, Hôtel Dieu Hospital, 1 place de l'Hôpital, 69288 Lyon, France. luc.thomas@chu-lyon.fr
authors.forename: S
authors.initials: S
authors.lastname: Ronger
authors.forename: A M
authors.initials: AM
authors.lastname: Viallard
authors.forename: F
authors.initials: F
authors.lastname: Meunier-Mure
authors.forename: B
authors.initials: B
authors.lastname: Chouvet
authors.forename: B
authors.initials: B
authors.lastname: Balme
authors.forename: L
authors.initials: L
authors.lastname: Thomas
mesh_terms: D000284:Administration, Oral; D002117:Calcitriol / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D018459:Lichen Sclerosus et Atrophicus / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D002117:Calcitriol