Insulin signaling: GLUT4 vesicles exit via the exocyst.
The localization of the GTP-binding protein TC10 to lipid raft microdomains has been suggested to play a role in the stimulation of GLUT4 translocation. The exocyst has now been identified as a downstream target for TC10, directing GLUT4-containing vesicles to the site of fusion.
Kanzaki
Makoto
M
The Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794-8651, USA. kanzaki@pharm.sunysb.edu
Pessin
Jeffrey E
JE
D005089:Exocytosis / Q000502:physiology; D051275:Glucose Transporter Type 4; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008954:Models, Biological; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D009124:Muscle Proteins; D015398:Signal Transduction; D022161:Transport Vesicles / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
D051275:Glucose Transporter Type 4; D007328:Insulin; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; C495692:SLC2A4 protein, human; C503256:RHOQ protein, human; D020741:rho GTP-Binding Proteins