Expression of KAI1/CD82 in human colorectal tumor.
OBJECTIVE
To study the expression of KAI1/CD82 in human colorectal tumor and its significance.


METHODS
Immunohistochemistry was used to detect the expression of CD82 in 40 colorectal carcinoma, 20 lymphatic metastasis, 18 adenoma and 20 normal colorectal epithelium specimens, respectively.


RESULTS
The expression of CD82 was rather low in adenoma and normal colorectal epithelium, with the positivity rates of 25% and 10% respectively; 28 of the 40 colorectal carcinoma specimens were positive for CD82, resulting in a positivity rate of 70%. The rate for lymphatic metastasis was only 5%. The differences between the 4 groups were significant (P <0.05), and the expression of CD82 in the carcinoma was not related to the histological grades (P >0.05), but was associated with the presence of metastasis (P <0.05).


CONCLUSIONS
CD82 is related to the progression of colorectal carcinoma.
Wu
De-hua
DH
Department of Radiation Oncology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Liu
Li
L
Chen
Long-hua
LH
Ding
Yan-qing
YQ
D000328:Adult; D000368:Aged; D015703:Antigens, CD; D003106:Colon / Q000737:chemistry; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051861:Kangai-1 Protein; D008207:Lymphatic Metastasis; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis*; D008875:Middle Aged; D011518:Proto-Oncogene Proteins
D015703:Antigens, CD; C497688:CD82 protein, human; D051861:Kangai-1 Protein; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins