The prevention of breast cancer.
BACKGROUND
Despite advances in the early detection and treatment of breast carcinoma, the mortality and morbidity rates associated with this disease remain high. Primary prevention, therefore, offers the best chance of making a major impact on outcome.


METHODS
The aim was to review the rationale, current stage of development and adverse effects of the strategies involved in the primary prevention of breast carcinoma. A review of the literature was undertaken by searching the MEDLINE database for the period 1966-2002 without language restrictions.


CONCLUSIONS
Currently, the only agent to have general approval for chemoprevention of breast carcinoma is tamoxifen. Women who derive the greatest benefit in terms of risk reduction from tamoxifen are premenopausal with a 5-year Gail risk factor of more than 1.66 per cent, postmenopausal with a 5-year Gail risk factor of more than 3 per cent, and postmenopausal without a uterus. In these specific subgroups, tamoxifen should be considered for the chemoprevention of breast carcinoma. Raloxifene, retinoids, aromatase inhibitors and cyclo-oxygenase 2 inhibitors require further clinical investigation before adoption in this context. Surgical intervention should largely be limited to those women who have a BRCA1 or BRCA2 mutation.
Prichard
R S
RS
Surgical Professorial Unit, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Hill
A D K
AD
Dijkstra
B
B
McDermott
E W
EW
O'Higgins
N J
NJ
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000178:diet therapy / Q000517:prevention & control* / Q000601:surgery; D002986:Clinical Trials as Topic; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D004311:Double-Blind Method; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005260:Female; D005544:Forecasting; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006801:Humans; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D012176:Retinoids / Q000627:therapeutic use; D013629:Tamoxifen / Q000627:therapeutic use
D018931:Antineoplastic Agents, Hormonal; D016861:Cyclooxygenase Inhibitors; D004965:Estrogen Antagonists; D012176:Retinoids; D013629:Tamoxifen; D020849:Raloxifene Hydrochloride