Screening and comparison of antioxidant activity of solvent extracts of herbal medicines used in Korea.
The hexane, ethylacetate, n-butanol, and water extracts of 10 Korean herbal medicines were screened and compared for their antioxidant activities in a range of lipid peroxidation system using rat brain homogenates, antihemolysis assay of red blood cells, and other in vitro assays to determine their ability to scavenge superoxide and hydroxyl radicals. All of the 10 Korean herbal medicines have potent antioxidant activities. Among the four solvent extracts, the antioxidant activities of more-polar solvent extracts (BuOH and water extracts) were relatively higher than that of non-polar solvent extracts (hexane and EtOAC extracts). These results will be useful to further analyze those herbal medicines that contain the most antioxidant activity in order to identify the active principles.
Kang
Dae Gill
DG
Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Medicinal Resources Research Center (MRRC), Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
Yun
Chi keun
Ck
Lee
Ho Sub
HS
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D016166:Free Radical Scavengers / Q000737:chemistry; D006461:Hemolysis / Q000187:drug effects; D017665:Hydroxyl Radical / Q000737:chemistry; D066298:In Vitro Techniques; D007723:Korea; D015227:Lipid Peroxidation / Q000187:drug effects; D008518:Medicine, East Asian Traditional; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012997:Solvents; D013481:Superoxides / Q000737:chemistry
D000975:Antioxidants; D016166:Free Radical Scavengers; D010936:Plant Extracts; D012997:Solvents; D013481:Superoxides; D017665:Hydroxyl Radical