title: Fresh amniotic membrane transplantation combined lamellar keratoplasty for patients with recurrent Mooren's ulcer.
abstract: OBJECTIVE
  To investigate the possibility of amniotic membrane as an immunological insulating band to reduce the recurrent frequency of Mooren's ulcer.
  
  
  METHODS
  Twelve cases(12 eyes) with recurrent Mooren's Ulcer were observed. Among them, 4 cases (4 eyes) were male and 8 cases(8 eyes) female, ranging in age between 26 and 51 years [mean(41 +/- 3) years]. Three eyes recurred once, 5 eyes twice, and 4 eyes three before. Eleven of 12 cases (11/12 eyes) with frequently recurrent Mooren's ulcer underwent lamellar keratoplasty combined amniotic membrane transplantation (AMT). One patient who had entire corneal ulceration accepted AMT alone.
  
  
  RESULTS
  Follow-up time is 12 to 29 months, [mean (23 +/- 6) months]. Before AMT, the recurrent frequency of Mooren's Ulcer of all cases after corneal surgery was 1-7 months [mean (3 +/- 2) months]. Nine of 12 eyes with lamellar keratoplasty combined AMT did not recur within the observation period; 2 eyes recurred 11 months after the surgery. Three months postoperatively, neovascularization was observed, which made it nearly impossible to decipher between amniotic membrane and its nearby conjunctiva, only at the junction of the transplant can some trails be observed. One case with entire AMT alone showed graft resolution and neovascularization in 1 month.
  
  
  CONCLUSIONS
  AMT combined with lamellar keratoplasty and lesion excision may delay recurrence of Mooren's Ulcer, reduce its recurrent frequency. Besides the effects of decreasing inflammation, it may have immunological insulating function as well. This conclusion should be proven by further clinical comparative study of much more samples.
authors.affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
authors.forename: Shiyou
authors.initials: S
authors.lastname: Zhou
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Chen
authors.forename: Bess
authors.initials: B
authors.lastname: Fung
authors.forename: Longshan
authors.initials: L
authors.lastname: Chen
mesh_terms: D000328:Adult; D000650:Amnion / Q000637:transplantation*; D016039:Corneal Transplantation / Q000379:methods; D003320:Corneal Ulcer / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence