Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors.
In order to verify whether azasugar would be a useful scaffold for inhibitory activity against metalloproteinases, we synthesized some azasugar-based compounds. As a result, it is clarified that azasugar moiety could function as successful inhibitor of matrix metalloproteinase-1, -3 and -9 and TACE.
Moriyama
Hideki
H
Japan Bioindustry Association, Hokkaido Collaboration Center, N-21, W-12, Kita-Ku, Sapporo 001-0021, Japan.
Tsukida
Takahiro
T
Inoue
Yoshimasa
Y
Kondo
Hirosato
H
Yoshino
Kohichiro
K
Nishimura
Shin-ichiro
S
D051722:ADAM Proteins; D000072198:ADAM17 Protein; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D005942:Gluconates / Q000737:chemistry*; D007700:Kinetics; D007783:Lactones; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry; D015032:Zinc / Q000737:chemistry
D001372:Aza Compounds; D005942:Gluconates; D007783:Lactones; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D013449:Sulfonamides; D051722:ADAM Proteins; D008666:Metalloendopeptidases; D000072198:ADAM17 Protein; D015032:Zinc; C010730:beta-glucono-1,5-lactone