title: Differential regulation of sensitizer-induced inflammation and immunity by acute restraint stress in allergic contact dermatitis.
abstract: Previously, we demonstrated that restraint stress applied before chemical sensitization modulates allergic contact dermatitis (ACD) differently than restraint applied before challenge. In this study, we asked if these dichotomous restraint-induced changes reflect modulation of the cutaneous microenvironment or changes in development of antigen-specific immunity in the lymph node (LN) of BALB/c mice. Our data confirm that restraint suppresses T cell-dependent immunity in ACD when applied prior to sensitization or prior to challenge and demonstrate that the stress-induced increase in ear swelling is due to heightened inflammation associated with ACD and is dependent upon the sensitization status of the mouse.
authors.affiliation: Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA.
authors.forename: Melanie S
authors.initials: MS
authors.lastname: Flint
authors.forename: Karyn M
authors.initials: KM
authors.lastname: Depree
authors.forename: Brenda A
authors.initials: BA
authors.lastname: Rich
authors.forename: Sally S
authors.initials: SS
authors.lastname: Tinkle
mesh_terms: D000279:Administration, Cutaneous; D019264:Adoptive Transfer; D000818:Animals; D000938:Antigen-Presenting Cells / Q000473:pathology; D002455:Cell Division / Q000276:immunology; D002465:Cell Movement / Q000235:genetics / Q000276:immunology; D017449:Dermatitis, Allergic Contact / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D004139:Dinitrofluorobenzene / Q000008:administration & dosage* / Q000276:immunology; D004431:Ear, External; D004487:Edema / Q000235:genetics / Q000276:immunology / Q000473:pathology; D007114:Immunization; D016130:Immunophenotyping; D007165:Immunosuppression Therapy; D007801:Langerhans Cells / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D012149:Restraint, Physical / Q000379:methods; D013045:Species Specificity; D013312:Stress, Physiological / Q000235:genetics / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism / Q000637:transplantation
chemical_list: D004139:Dinitrofluorobenzene