title: [Study on pharmacokinetics of ferulic acid and paeoniflorin in Angelic-Paeonia root powder].
abstract: OBJECTIVE
  To study pharmacokinetics of ferulic acid and paeoniflorin that are two chief active compounds in Angelic-Paeonia Root Powder (APRP).
  
  
  METHODS
  After the mice were administered by APRP through ig, HPLC was used to determine ferulic acid and paeoniflorin concentration in serum at different times. 3P87 procedure was used to process concentration-time data.
  
  
  RESULTS
  Ferulic acid and paeoniflorin were detected from serum in the mice. The pharmacokinetics parameters were: Ferulic acid: Ke = 0.330 +/- 0.085 1/h, Ka = 0.555 +/- 0.133 1/h, t1/2(ka) = 1.249 +/- 0.365 h, t1/2(ke) = 2.101 +/- 0.665 h, Tpeak = 2.606 +/- 0.586 h, Cmax = 6.372 +/- 1.510 mg.L-1, AUC = 41.399 +/- 11.763 mg.h-1.L-1; Paeoniflorin: Ke = 0.511 +/- 0.117 1/h, Ka = 0.656 +/- 0.121 1/h, t1/2(Ka) = 1.056 +/- 0.263 h, t1/2(Ke) = 1.356 +/- 0.281 h, Tpeak = 2.062 +/- 0.396 h, Cmax = 3.401 +/- 0.879 mg.L-1, AUC = 16.047 +/- 3.767 mg.L-1. The present research provided valuable data for rational clinical practice of APRP.
authors.affiliation: College of Pharmacy, Drug Research Center, College of Pharmacy, Jinan University, Guangzhou 510632.
authors.forename: Huanmin
authors.initials: H
authors.lastname: Luo
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Li
authors.forename: Fei
authors.initials: F
authors.lastname: Xiao
authors.forename: Feng
authors.initials: F
authors.lastname: Gu
mesh_terms: D029971:Angelica sinensis / Q000737:chemistry*; D000818:Animals; D019540:Area Under Curve; D001565:Benzoates / Q000032:analysis / Q000493:pharmacokinetics*; D001952:Bridged-Ring Compounds / Q000032:analysis / Q000493:pharmacokinetics*; D003373:Coumaric Acids / Q000032:analysis / Q000493:pharmacokinetics*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005260:Female; D005960:Glucosides / Q000032:analysis / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D039821:Monoterpenes; D029596:Paeonia / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D011208:Powders; D006027:Glycosides
chemical_list: D001565:Benzoates; D001952:Bridged-Ring Compounds; D003373:Coumaric Acids; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D039821:Monoterpenes; D011208:Powders; C413220:toki-shakuyaku-san; C015423:peoniflorin; D006027:Glycosides; C004999:ferulic acid