In vitro activities of 25 quinolones and fluoroquinolones against liver and blood stage Plasmodium spp.
The in vitro activities of 25 quinolones and fluoroquinolones against erythrocytic stages of Plasmodium falciparum and against liver stages of Plasmodium yoelii yoelii and P. falciparum were studied. All compounds were inhibitory for chloroquine-sensitive and chloroquine-resistant P. falciparum grown in red blood cells. This inhibitory effect increased with prolonged incubation and according to the logarithm of the drug concentration. Grepafloxacin, trovafloxacin, and ciprofloxacin were the most effective drugs, with 50% inhibitory concentrations of <10 micro g/ml against both strains. Only grepafloxacin, piromidic acid, and trovafloxacin had an inhibitory effect against hepatic stages of P. falciparum and P. yoelii yoelii; this effect combined reductions of the numbers and the sizes of schizonts in treated cultures. Thus, quinolones have a potential for treatment or prevention of malaria through their unique antiparasitic effect against erythrocytic and hepatic stages of Plasmodium.
Mahmoudi
Nassira
N
INSERM U511, Immuno-biologie Cellulaire et Moléculaire des Infections Parasitaires, CHU Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Université Pierre et Marie Curie-Paris, 75013 Paris, France. nassira@netcourrier.com
Ciceron
Liliane
L
Franetich
Jean-François
JF
Farhati
Khemais
K
Silvie
Olivier
O
Eling
Wijnand
W
Sauerwein
Robert
R
Danis
Martin
M
Mazier
Dominique
D
Derouin
Francis
F
D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004912:Erythrocytes / Q000469:parasitology*; D024841:Fluoroquinolones; D008099:Liver / Q000469:parasitology*; D051379:Mice; D010961:Plasmodium / Q000187:drug effects* / Q000254:growth & development; D010963:Plasmodium falciparum / Q000187:drug effects / Q000235:genetics; D010967:Plasmodium yoelii / Q000187:drug effects / Q000235:genetics
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones