Studies of murine systemic autoimmunity.
Systemic autoimmunity is an important clinical problem, offering a window into fundamental questions of self-nonself tolerance. We have used cellular immunology, serology, and immunopathology to approach several spontaneous mouse models. Although much remains to be done, a picture is emerging of pathological antigen-driven immune responses to self nuclear antigens, highly dependent on multiple genes, and susceptible to abnormalities of apoptosis.
Cohen
Philip L
PL
University of Pennsylvania, Philadelphia, PA, USA. philipco@mail.upenn.edu
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D015551:Autoimmunity; D004195:Disease Models, Animal; D007108:Immune Tolerance; D008264:Macrophages / Q000276:immunology; D051379:Mice; D013312:Stress, Physiological / Q000276:immunology; D016159:Tumor Suppressor Protein p53 / Q000276:immunology
D016159:Tumor Suppressor Protein p53