Therapeutic potential of the plasma proteome.
Plasma contains numerous and diverse proteins with existing and potential therapeutic value. Plasma has been used clinically as both a source of purified derivatives for treating diseases such as hemophilia, and as a diagnostic medium. Recent research directed towards mining plasma's true potential takes advantage of state-of-the-art proteomic analytical methods to develop multi-protein, disease-specific biomarker panels to improve the reliability and specificity of diagnostics. Recombinant production and chromatographic purification methods are increasing the yield and safety of traditional plasma derivatives. Emerging cell-based technologies are being applied to discover novel protein activities and identify epitope-specific antibodies that may have clinical promise.
Lathrop
Julia Tait
JT
Plasma Derivatives Department, Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA. lathropj@usa.redcross.org
Anderson
N Leigh
NL
Anderson
Norman G
NG
Hammond
David J
DJ
D000906:Antibodies / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D025202:Molecular Diagnostic Techniques; D020543:Proteome
D000906:Antibodies; D015415:Biomarkers; D001798:Blood Proteins; D020543:Proteome