Regulation of ion channel/neurotransmitter receptor function by RNA editing.
RNA editing by select adenosine deamination (A-to-I editing) alters functional determinants in certain ion channels and neurotransmitter receptors in vertebrates and invertebrates. In most cases, edited and unedited versions of a given receptor/channel co-exist to expand the functional space of the receptor population. Recent studies have characterized K(+) channels in squid that are edited at multiple positions, revealed a role for Q/R site editing in AMPA receptor assembly, and demonstrated a link between serotonin levels and the extent of editing of a mammalian serotonin receptor.
Seeburg
Peter H
PH
Department of Molecular Neurobiology, Max-Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany. seeburg@mpimf-heidelberg.mpg.de
Hartner
Jochen
J
D000818:Animals; D006801:Humans; D007473:Ion Channels / Q000737:chemistry / Q000502:physiology*; D017393:RNA Editing / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000737:chemistry / Q000502:physiology*
D007473:Ion Channels; D017981:Receptors, Neurotransmitter