[Vasorelaxant activity of caffeic acid derivatives from Cichorium intybus and Equisetum arvense].
The vasorelaxant activities of chicoric acid (Compound 1) from Cichorium intybus and dicaffeoyl-meso-tartaric acid (Compound 2) from Equisetum arvense L. in isolated rat aorta strips were studied. Compound 1 is a diester composed of (S,S)-tartaric acid and caffeic acid, and 2 is composed of its meso type. Both 1 and 2 showed slow relaxation activity against norepinephrine (NE)-induced contraction of rat aorta with/without endothelium. These compounds did not affect contraction induced by a high concentration of potassium (60 mM K+), while they inhibited NE-induced vasocontraction in the presence of nicardipine. These results show that the inhibition by 1 and 2 of NE-induced vasocontraction is due to a decrease in calcium influx from the extracellular space caused by NE. In addition, dicaffeoyl tartaric acids showed vasorelaxant activity, regardless of their stereochemistry.
Sakurai
Nobuko
N
Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Iizuka
Tohru
T
Nakayama
Shigeki
S
Funayama
Hiroko
H
Noguchi
Mariko
M
Nagai
Masahiro
M
D000818:Animals; D001011:Aorta / Q000187:drug effects; D002109:Caffeic Acids / Q000494:pharmacology*; D018651:Cichorium intybus / Q000737:chemistry*; D020829:Equisetum / Q000737:chemistry*; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D002109:Caffeic Acids