title: [Immune status in children with psychomotor development disturbances].
abstract: Leukocyte elastase (LE) activity and autoantibodies to nerve growth factor (NGF) level as indexes of innate and adaptive immunity have been studied in children with psychomotor development disturbances of cerebral organic origin. LE activity was elevated in mild and moderate degrees of psychomotor disturbances caused by perinatal encephalopathy. In psychomotor disturbances of cerebral organic origin, higher LE activity was accompanied by a significant increase of autoantibodies to NGF titers. Correlations between immunological parameters and some clinical symptoms were found. The results obtained suggest involvement of innate and adaptive immune system links in pathophysiology of psychomotor development disturbances in children.
authors.forename: I V
authors.initials: IV
authors.lastname: Shcherbakova
authors.forename: L G
authors.initials: LG
authors.lastname: Khachatrian
authors.forename: S A
authors.initials: SA
authors.lastname: Krasnolobova
authors.forename: R R
authors.initials: RR
authors.lastname: Lideman
authors.forename: T P
authors.initials: TP
authors.lastname: Kliushnik
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D006801:Humans; D007109:Immunity; D007223:Infant; D019272:Leukocyte Elastase / Q000097:blood*; D020932:Nerve Growth Factor / Q000276:immunology; D011596:Psychomotor Disorders / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D020932:Nerve Growth Factor; D019272:Leukocyte Elastase