Influence of changes in glutathione concentration on body temperature and tolerance to cerebral ischemia.
Two compounds that deplete glutathione (buthionine sulfoximine and diethyl maleate) with different mechanisms of action decrease body temperature and increase tolerance to complete global cerebral ischemia, both correlating closely with the glutathione concentration decrease. Glutathione apparently participates in the regulations of these functional parameters. GSH diethyl ester does not influence the latter, though it increases moderately the GSH concentration. Injection of GSH ester into the cerebral ventricles or subcutaneously selectively increases the GSH level in the brain and liver. An influence of the brain on the glutathione system in the liver was revealed. Diethyl maleate and GSH ester increase the activity of glutathione metabolizing enzymes under certain conditions.
Kolesnichenko
L S
LS
Department of Bioorganic and Bioinorganic Chemistry, Irkutsk State Medical University, Irkutsk 664003, Russia. kulinsky@pp.irkutsk.ru
Kulinsky
V I
VI
Sotnikova
G V
GV
Kovtun
V Yu
VY
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002545:Brain Ischemia / Q000378:metabolism*; D019328:Buthionine Sulfoximine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008991:Monitoring, Physiologic
D019328:Buthionine Sulfoximine; D005978:Glutathione