title: Virgin olive and fish oils enhance the hepatic antioxidant defence system in atherosclerotic rabbits.
abstract: OBJECTIVE
  In this study we report the effects of sunflower, virgin olive and fish oils on the lipid profile and antioxidant defence system in liver mitochondria from rabbits with experimental atherosclerosis.
  
  
  METHODS
  An atherogenic control group were fed for 50 days on a diet containing 3% lard and 1.3% cholesterol. Four groups were fed for an additional period of 30 days with a diet enriched in different oils: sunflower oil, virgin olive oil, refined olive oil and fish oil. A control group was fed with a standard chow.
  
  
  RESULTS
  The atherogenic diet caused important changes in the hepatic mitochondria lipid profile and in the enzymatic and non-enzymatic antioxidant defence system accompanied with an increase in the content of hydroperoxides in liver mitochondria. The administration of virgin olive and fish oils showed a better profile in the antioxidant system as well as decrease in the content of hydroperoxides.
  
  
  CONCLUSIONS
  The intake of cholesterol- and lard-enriched diet leads to a high impairment in the hepatic antioxidant defence system. However, the replacement of that diet by other unsaturated fat-enriched diets using virgin olive, sunflower and fish oil enhances hepatic antioxidant defence system, virgin olive and fish oil diet provide the best results.
authors.affiliation: Department of Biochemistry and Molecular Biology University of Granada, C/Ramón y Cajal 4 18071-Granada, Spain.
authors.forename: C M
authors.initials: CM
authors.lastname: Aguilera
authors.forename: M D
authors.initials: MD
authors.lastname: Mesa
authors.forename: M C
authors.initials: MC
authors.lastname: Ramírez-Tortosa
authors.forename: J L
authors.initials: JL
authors.lastname: Quiles
authors.forename: A
authors.initials: A
authors.lastname: Gil
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D001161:Arteriosclerosis / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D004036:Diet, Atherogenic; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000494:pharmacology; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology; D005979:Glutathione Peroxidase / Q000378:metabolism; D008054:Lipid Peroxides / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000737:chemistry / Q000201:enzymology / Q000378:metabolism*; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology; D011817:Rabbits; D011897:Random Allocation; D000074242:Sunflower Oil; D013482:Superoxide Dismutase / Q000378:metabolism; D014801:Vitamin A / Q000032:analysis; D024502:alpha-Tocopherol / Q000032:analysis
chemical_list: D000975:Antioxidants; D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005395:Fish Oils; D008054:Lipid Peroxides; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil; D014801:Vitamin A; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D024502:alpha-Tocopherol