[Molecular factors promoting carcinogenesis and malignant behavior of intraductal papillary mucinous tumors].
Many molecular factors related to the carcinogenesis and malignant behavior of pancreatic cancer were identified by investigation of intraductal papillary mucinous tumors (IPMTs). Molecules controlling the G1/S phase, such as p53, p21, p61, and cyclin D1, tumor suppressors including DPC-4, and many other factors such as MUC-1/2 contribute to the promotion of the malignant behavior of IPMTs. They will be important molecular targets for the radical treatment of pancreatic cancer.
Ichikawa
Yasushi
Y
Department of Surgery-II, Yokohama City University, School of Medicine, Yokohama, Japan.
Ueda
Michio
M
Miura
Yasuhiko
Y
Kunihiro
Satoshi
S
Ishikawa
Takashi
T
Endo
Itaru
I
Sekido
Hitoshi
H
Shimada
Hiroshi
H
D002288:Adenocarcinoma, Mucinous / Q000235:genetics / Q000473:pathology*; D000231:Adenocarcinoma, Papillary / Q000235:genetics / Q000473:pathology*; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics / Q000473:pathology*; D002453:Cell Cycle; D011905:Genes, ras; D006801:Humans; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000473:pathology*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53