Takanawaenes, novel antifungal antibiotics produced by Streptomyces sp. K99-5278. I. Taxonomy, fermentation, isolation and biological properties.
Three new pentaene macrolides having a 28-membered ring, designated takanawaenes A, B and C, were isolated from the fermentation broth of Streptomyces sp. K99-5278 by solvent extraction, silica-gel column chromatography and HPLC. Takanawaenes showed antifungal activity against Aspergillus niger, Mucor racemosus, Candida albicans and Saccharomyces cerevisiae.
Kim
Yong-Pil
YP
Kitasato Institute for Life Sciences, Kitasato University and The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Tomoda
Hiroshi
H
Iizima
Kousuke
K
Fukuda
Takashi
T
Matsumoto
Atsuko
A
Takahashi
Yoko
Y
Omura
Satoshi
S
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D011090:Polyenes / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism
D000935:Antifungal Agents; D007783:Lactones; D011090:Polyenes; C476106:takanawaene A; C476108:takanawaene B; C476109:takanawaene C