title: Bilateral combined retinal and choroidal detachment in antineutrophil cytoplasmic antibody-positive scleritis.
abstract: OBJECTIVE
  To describe a rare complication of scleritis in a patient with positive serum antineutrophil cytoplasmic antibodies (ANCA).
  
  
  METHODS
  We present a case report of a patient who developed bilateral retinal and choroidal detachment associated with ANCA-positive scleritis.
  
  
  RESULTS
  Oral steroids alone were insufficient to maintain sustained remission of ocular inflammation. Clinical relapse of the scleritis was associated with ANCA titres becoming positive again. A combination of cyclophosphamide and steroids was successful in achieving control of the intraocular inflammation over a follow-up period of 18 months.
  
  
  CONCLUSIONS
  Bilateral combined retinal and choroidal detachment is a potentially blinding complication of ANCA-positive scleritis. Monitoring of ANCA titres is useful in the management of the disease.
authors.affiliation: Birmingham and Midland Eye Centre, City Hospital NHS Trust, Birmingham B18 7QU, UK.
authors.forename: B Non
authors.initials: BN
authors.lastname: Matthews
authors.forename: Panagiota
authors.initials: P
authors.lastname: Stavrou
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D015862:Choroid Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence; D012163:Retinal Detachment / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D015423:Scleritis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D014463:Ultrasonography
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D005938:Glucocorticoids; D003520:Cyclophosphamide; D011239:Prednisolone