title: Autoimmune hepatitis revealed by atorvastatin.
abstract: Cases of acute hepatitis induced by statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) have been reported. A 65-year-old woman was admitted to our hospital because of fatigue, jaundice and altered liver function tests while on treatment with atorvastatin. On the basis of clinical, serological and histological findings, a score leading to a diagnosis of autoimmune hepatitis was reached. We suggest that atorvastatin may have revealed an underlying autoimmune hepatitis.
authors.affiliation: Department of Internal Medicine, Clinical Immunology Unit, University of Genoa, Genoa, Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Pelli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Setti
authors.forename: Paola
authors.initials: P
authors.lastname: Ceppa
authors.forename: Carlo
authors.initials: C
authors.lastname: Toncini
authors.forename: Francesco
authors.initials: F
authors.lastname: Indiveri
mesh_terms: D000368:Aged; D000410:Alanine Transaminase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D000069059:Atorvastatin; D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000473:pathology; D001663:Bilirubin / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005260:Female; D006538:Heptanoic Acids / Q000009:adverse effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D011758:Pyrroles / Q000009:adverse effects*
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin