Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans.
BACKGROUND
Recent genetic animal models reveal important roles of platelet P-selectin on progression of atherosclerosis. In the present study, we examine the relation between platelet P-selectin expression and atherosclerotic parameters in 517 subjects.


RESULTS
Unrelated subjects (n=517; 235 male and 282 female), including 187 with type 2 diabetes, 184 with hypertension, and 366 with hyperlipidemia, were enrolled in the study. P-selectin expression was determined by whole-blood flow cytometry. Arterial stiffness (stiffness index beta) and arterial wall thickness (intima-media thickness [IMT]) were determined by carotid ultrasound. P-selectin expression was significantly and positively correlated with carotid IMT and stiffness index beta. Multiple regression analyses showed that the association of the percentage of P-selectin-positive platelets with carotid IMT was independent of other clinical factors. Moreover, the percentage of P-selectin-positive platelets was higher in subjects with carotid plaque and was an independent factor associated with occurrence of carotid plaque analyzed by multiple logistic regression analysis. Finally, the percentage of P-selectin-positive platelets was positively associated with age, body mass index, systolic and diastolic blood pressure, and HbA1c and inversely associated with HDL cholesterol.


CONCLUSIONS
Platelet P-selectin is independently associated with atherosclerotic arterial wall changes in human subjects.
Koyama
Hidenori
H
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. hidekoyama@med.osaka-cu.ac.jp
Maeno
Takaaki
T
Fukumoto
Shinya
S
Shoji
Takuhito
T
Yamane
Takahisa
T
Yokoyama
Hisayo
H
Emoto
Masanori
M
Shoji
Tetsuo
T
Tahara
Hideki
H
Inaba
Masaaki
M
Hino
Masayuki
M
Shioi
Atsushi
A
Miki
Takami
T
Nishizawa
Yoshiki
Y
D000367:Age Factors; D001792:Blood Platelets / Q000378:metabolism* / Q000473:pathology; D001794:Blood Pressure; D015992:Body Mass Index; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D002340:Carotid Artery Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005434:Flow Cytometry; D006442:Glycated Hemoglobin / Q000032:analysis / Q000378:metabolism; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D019007:P-Selectin / Q000032:analysis / Q000096:biosynthesis*; D011237:Predictive Value of Tests; D012044:Regression Analysis; D017539:Tunica Intima / Q000000981:diagnostic imaging; D017540:Tunica Media / Q000000981:diagnostic imaging; D014463:Ultrasonography
D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin; D019007:P-Selectin