[Change of nuclear factor-kappaB activity in early burn injury and its significance].
OBJECTIVE
To study the change of nuclear factor-kappaB(NF-kappaB) activity in the blood leukocytes of rats in the early period after severe burn injury and its significance.


METHODS
To examine the change of NF-kappaB activity in leukocytes of blood of rats in the early period(48 hours) after severe burn injury to show its relation with tumor necrosis factor-alpha(TNF-alpha) and intercellular adhesion molecule-1(ICAM-1).


RESULTS
The activity of NF-kappaB after burn injury was increased than that was before burn injury, and reached the peak at the 12 hours. TNF-alpha, ICAM-1 and polymorphonuclear neutrophilic leucocytes(PMN) in plasma had the similar changeable patterns, and NF-kappaB had the positive correlation with TNF-alpha, ICAM-1 and PMN.


CONCLUSIONS
The activity of NF-kappaB is increased in blood leukocytes in the early period after severe burn injury. It may play an important role in systemic inflammatory response syndrome(SIRS) and multiple organ dysfunction syndrome(MODS) after burn injury.
Liao
Jian-kun
JK
Emergency Department, Guangdong Provincial Crops Hospital, Chinese People's Armed Police Forces, Guangzhou 510507, Guangdong, China.
Liao
Hong-mei
HM
Luo
Xue-hong
XH
D000818:Animals; D002056:Burns / Q000378:metabolism*; D005260:Female; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D016328:NF-kappa B / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1