Effect of catechol derivatives on cell growth and lipoxygenase activity.
Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC(50)10(-6)-10(-7) M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC(50) approximately 1 microM).
Simpson
Julie
J
School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK.
Forrester
Rebecca
R
Tisdale
Michael J
MJ
Billington
David C
DC
Rathbone
Daniel L
DL
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001092:Arachidonate 12-Lipoxygenase / Q000378:metabolism; D001093:Arachidonate 15-Lipoxygenase / Q000378:metabolism; D016718:Arachidonic Acid / Q000378:metabolism; D002396:Catechols / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D007202:Indicators and Reagents; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D008968:Molecular Conformation; D011817:Rabbits; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D002396:Catechols; D007202:Indicators and Reagents; D016859:Lipoxygenase Inhibitors; D016718:Arachidonic Acid; D001092:Arachidonate 12-Lipoxygenase; D001093:Arachidonate 15-Lipoxygenase