title: High risk HPV types in southern Iranian patients with cervical cancer.
abstract: This study was undertaken to assess the rate of HPV infection in cervical carcinoma among southern Iranian patients. 101 archival cervical carcinoma tissue samples of a 10 year period were studied for the presence of HPV DNA in southern Iran by a polymerase chain reaction method. In addition, the presence of high risk HPV-16 and HPV-18 genotypes was investigated. In total, 88 (87.1%) of the samples were HPV DNA positive, of which 83 were squamous cell carcinomas and 5 were adenocarcinomas. HPV-16 genotype was detected in 26.7% of HPV positive cervical carcinomas; however, none of the samples were positive for the existence of HPV-18 genotype. Collectively, these results suggest that HPV-16 and HPV-18 are not the frequent high risk HPV types in our patients and circulating HPV types in southern Iranian population are different from many other populations.
authors.affiliation: Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Farjadian
authors.forename: E
authors.initials: E
authors.lastname: Asadi
authors.forename: M
authors.initials: M
authors.lastname: Doroudchi
authors.forename: A Samsami
authors.initials: AS
authors.lastname: Dehaghani
authors.forename: S Z
authors.initials: SZ
authors.lastname: Tabei
authors.forename: V P
authors.initials: VP
authors.lastname: Kumar
authors.forename: A
authors.initials: A
authors.lastname: Ghaderi
mesh_terms: D000230:Adenocarcinoma / Q000821:virology*; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005838:Genotype; D006801:Humans; D007492:Iran; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000821:virology*; D016133:Polymerase Chain Reaction; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000821:virology*
chemical_list: D004279:DNA, Viral