Genetic targeting of cerebellar Purkinje cells: history, current status and novel strategies.
This review is an account of developments in the field of transgenic and gene targeting approaches with special emphasis on the cerebellar Purkinje cell. A critical discussion of the available genetic tools is provided. As genetic engineering of the mouse is still a rapidly moving field, we felt it appropriate to include some ideas on novel strategies for refined genetic manipulations.
Barski
Jaroslaw J
JJ
Max-Planck-Institute of Neurobiology, Department of Neurobiochemistry, Martinsried, Germany. barski@neuro.mpg.de
Lauth
Matthias
M
Meyer
Michael
M
D000818:Animals; D030801:Animals, Genetically Modified / Q000378:metabolism / Q000502:physiology; D017353:Gene Deletion; D018390:Gene Targeting / Q000379:methods; D006801:Humans; D011689:Purkinje Cells / Q000378:metabolism* / Q000502:physiology; D011995:Recombination, Genetic; D020127:Recovery of Function / Q000235:genetics; D019076:Transgenes / Q000502:physiology*