[Interferon alpha-2b inhibits rabbit corneal haze induced by PRK].
OBJECTIVE
To evaluate the effect of interferon alpha-2b on the treatment of corneal haze after PRK.


METHODS
36 rabbits were divided into three groups (A.B.C). The refractive degree of ablation was -4.00 D, -8.00 D, -10.00 D in each group respectively. The treatment given in group A was 1 x 10(5) IU/ml interferon alpha-2b, in group B 0.1% dexamethasone and placebo eyedrops for group C after PRK 2 months. Corneal haze, histopathologic response, intraocular pressure (IOP) were investigated.


RESULTS
Less corneal haze was observed in group A and B. Postoperative IOP was higher than that of preoperation in group B. Keratocytes and fibrotic response in corneal stroma were active up to 2 months in group C.


CONCLUSIONS
Interferon alpha-2b was effective on inhibition of corneal haze after PRK.
Zhang
Ming-Chang
MC
Department of Ophthalmology, Union Hospital Tongji Medical College of Huazhong University of Science & Technology, Wuhan 430022, China. mingchangzhang488@hotmail.com
Li
Bin
B
Hu
Yan-Hua
YH
Yan
Hao
H
D000818:Animals; D003318:Corneal Opacity / Q000188:drug therapy* / Q000473:pathology; D019573:Epithelium, Corneal / Q000187:drug effects*; D005260:Female; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000627:therapeutic use*; D054018:Lasers, Excimer; D008297:Male; D018903:Photorefractive Keratectomy / Q000009:adverse effects*; D011817:Rabbits; D011994:Recombinant Proteins
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins