Serotonin syndrome and other serotonergic disorders.
Serotonin syndrome is an iatrogenic disorder induced by pharmacologic treatment with serotonergic agents that increases serotonin activity. In addition, there is a wide variety of clinical disorders associated with serotonin excess. The frequent concurrent use of serotonergic and neuroleptic drugs and similarities between serotonin syndrome and neuroleptic malignant syndrome can present the clinician with a diagnostic challenge. In this article, we review the pathophysiology, diagnosis, and treatment of serotonin syndrome as well as other serotonergic disorders.
Ener
Rasih Atilla
RA
MCP Hahnemann University Hospitals, Philadelphia, Pennsylvania 19102, USA. rae22@drexel.edu
Meglathery
Sharon B
SB
Van Decker
William A
WA
Gallagher
Rollin M
RM
D014150:Antipsychotic Agents / Q000009:adverse effects; D006801:Humans; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis / Q000503:physiopathology; D012701:Serotonin / Q000378:metabolism; D020230:Serotonin Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
D014150:Antipsychotic Agents; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors