title: Hyperkalemia induced by the calcium channel blocker, benidipine.
abstract: A 73-year-old hypertensive, non-diabetic woman without obvious renal dysfunction had frequently been hyperkalemic over four years after receiving antihypertensive drugs including the calcium channel blocker (CCB) benidipine. One week after all medications were accidentally discontinued, the serum potassium level returned to normal. After we obtained the informed consent of the patient, benidipine alone was administered again for over two weeks and hyperkalemia developed once more. This previously uncommon side effect of hyperkalemia induced by benidipine is not very serious but it is apt to be overlooked. Since CCBs are now widely prescribed, the development of hyperkalemia should be considered.
authors.affiliation: First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-1692.
authors.forename: Takuroh
authors.initials: T
authors.lastname: Imamura
authors.forename: Yunosuke
authors.initials: Y
authors.lastname: Matsuura
authors.forename: Toshiro
authors.initials: T
authors.lastname: Nagoshi
authors.forename: Tetsunori
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Date
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kita
authors.forename: Akihiko
authors.initials: A
authors.lastname: Matsuyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsuo
authors.forename: Tanenao
authors.initials: T
authors.lastname: Eto
mesh_terms: D000368:Aged; D002121:Calcium Channel Blockers / Q000009:adverse effects* / Q000627:therapeutic use; D004095:Dihydropyridines / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced* / Q000503:physiopathology; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy*; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C061004:benidipine