[Epithelial ovarian cancer--preoperative assessment of Ca 125 levels as an independent prognostic factor].
The aim of our study was to assess the relationship between the preoperative assessment of Cal25 levels in patients with primary ovarian cancer.


METHODS
Two hundred and thirteen patients with epithelial ovarian cancer were preoperatively examined for the levels of Cal25. They were assessed retrospectively. The relationship between the preoperatively levels of Cal25 and different preoperative and postoperative variables were examined.


RESULTS
The mean level of Cal25 for all the patients was 623 U/ml/normal range to 35 U/ml/. The preoperative levels of Cal25 have no relationship with increased age, but are very much connected with the histological type--mainly with serous component. Mean levels of Cal25 with serous histology is 780 U/ml and other histological types is 322 U/ml, p = .03. In patients with high stage /III/IV/ the levels are 783 against 145 U/ml--with lower stage--p < .001. In patients with tumor grade /3/ the levels of Cal25 are 956 U/ml against with low tumor grade 12.11 the levels of Cal25 are 34711/ml, p < 0.01. The presence of ascites is connected with Cal25 levels--897 U/ml against without ascites Cal25 levels are 230 U/ml, p < .001. Patients received inadequate cytoreduction /with big residual tumor/were connected with significantly higher Cal25 levels--1125 U/ml against patients with optimal cytoreduction--403 U/ml, p < .001. The preoperative levels of Cal25 less than 450 U/ml have positive predictive value for optimal cytoreduction--78% and negative predictive value 39%. We found significant relationship between the levels of Cal25 and the survival of the patients. With the increase of preoperative levels of Cal25 is increasing the risk of death for the patients.


CONCLUSIONS
We think tht the preoperative evaluation of the Cal25 levels can be an independent risk factor, which can define the death rate in the patients with ovarian cancer, but not always the levels can be the ideal factor predicting optimal cytoreduction. Nevertheless this the levels of Cal25 can significantly help the oncogynaecologist in the fight against the ovarian cancer.
Ivanov
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Ivanov
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D014408:Biomarkers, Tumor / Q000032:analysis*; D018394:CA-125 Antigen / Q000032:analysis*; D002277:Carcinoma / Q000097:blood / Q000175:diagnosis* / Q000601:surgery*; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000473:pathology; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000601:surgery*; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011379:Prognosis; D012189:Retrospective Studies
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen