Propylthiouracil (PTU)-induced vasculitis associated with antineutrophil antibody against myeloperoxidase (MPO-ANCA).
A 54-year-old woman had been administered propylthiouracil (PTU) for Graves' disease for 4 years. Recently, she complained of hemoptysis due to pulmonary alveolar hemorrhage causing anemia, and also had microhematuria. Antineutrophil cytoplasmic antibody against myeloperoxidase (MPO-ANCA) was positive, and she was diagnosed with PTU-induced vasculitis. Cessation of PTU and the administration of corticosteroids ameliorated these manifestations.
Nakamori
Yoshitaka
Y
Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu 747-8511.
Tominaga
Takayuki
T
Inoue
Yasushi
Y
Shinohara
Kenji
K
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D001774:Blood Chemical Analysis; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D009195:Peroxidase / Q000276:immunology; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use; D018570:Risk Assessment; D012720:Severity of Illness Index; D013960:Thyroid Function Tests; D014057:Tomography, X-Ray Computed; D014657:Vasculitis / Q000139:chemically induced* / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic; D011441:Propylthiouracil; D009195:Peroxidase