Hyperkalemia induced by the calcium channel blocker, benidipine.
A 73-year-old hypertensive, non-diabetic woman without obvious renal dysfunction had frequently been hyperkalemic over four years after receiving antihypertensive drugs including the calcium channel blocker (CCB) benidipine. One week after all medications were accidentally discontinued, the serum potassium level returned to normal. After we obtained the informed consent of the patient, benidipine alone was administered again for over two weeks and hyperkalemia developed once more. This previously uncommon side effect of hyperkalemia induced by benidipine is not very serious but it is apt to be overlooked. Since CCBs are now widely prescribed, the development of hyperkalemia should be considered.
Imamura
Takuroh
T
First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-1692.
Matsuura
Yunosuke
Y
Nagoshi
Toshiro
T
Ishikawa
Tetsunori
T
Date
Haruhiko
H
Kita
Toshihiro
T
Matsuyama
Akihiko
A
Matsuo
Takeshi
T
Eto
Tanenao
T
D000368:Aged; D002121:Calcium Channel Blockers / Q000009:adverse effects* / Q000627:therapeutic use; D004095:Dihydropyridines / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced* / Q000503:physiopathology; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy*; D018570:Risk Assessment; D012720:Severity of Illness Index
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C061004:benidipine