Topical mitomycin C-induced inhibition of postlaminectomy peridural fibrosis in rabbits.
OBJECTIVE
The authors conducted a study to determine the effectiveness of mitomycin C in preventing postlaminectomy peridural fibrosis in rabbits.


METHODS
Laminectomies were performed at L-4 in 12 rabbits. Color-coded cotton pads soaked either with 0.02% mitomycin C or saline were applied in a blinded fashion to the operative sites, with saline-treated laminectomy sites serving as controls. The rabbits were killed 30 days after surgery. The extent of peridural fibrosis was evaluated by histological analysis. The mitomycin C-treated sites showed significantly decreased peridural fibrosis.


CONCLUSIONS
Peridural fibrosis can be a devastating condition that develops after laminectomy. Topical application of mitomycin C may be a successful method of preventing postlaminectomy peridural fibrosis.
Dogulu
Fikret
F
Department of Neurosurgery, Gazi University School of Medicine, Ankara, Turkey. fdogulu@hotmail.com
Kurt
Gokhan
G
Emmez
Hakan
H
Erdem
Ozlem
O
Memis
Leyla
L
Baykaner
Kemali
K
Ceviker
Necdet
N
D000287:Administration, Topical; D000477:Alkylating Agents / Q000008:administration & dosage*; D000818:Animals; D004388:Dura Mater; D005260:Female; D005355:Fibrosis / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy; D007796:Laminectomy / Q000009:adverse effects*; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D011817:Rabbits
D000477:Alkylating Agents; D016685:Mitomycin