Production of teicoplanin by a mutant of Actinoplanes teicomyceticus.
Teicoplanin, a glucopeptide antibiotic, was produced by a mutant of Actinoplanes teicomyceticus at 300 mg l-1 using mannose and yeast extract as carbon and nitrogen sources in flask culture and at 500 mg l-1 in 5-1 jar fermenter. Teicoplanin production was 25-fold higher than in the parent strain.
Lee
Jae-Chan
JC
Korea Research Institute of Bioscience & Biotechnology, P.O. Box 115, Yusong, Daejon 305-600, Korea.
Park
Hae-Ryong
HR
Park
Dong-Jin
DJ
Son
Kwang Hee
KH
Yoon
Ki-Hong
KH
Kim
Young-Bae
YB
Kim
Chang-Jin
CJ
D000192:Actinomycetales / Q000235:genetics* / Q000378:metabolism*; D003470:Culture Media / Q000737:chemistry; D005285:Fermentation; D007218:Industrial Microbiology / Q000379:methods*; D008358:Mannose / Q000378:metabolism; D009154:Mutation; D017334:Teicoplanin / Q000096:biosynthesis*
D003470:Culture Media; D017334:Teicoplanin; D008358:Mannose