Diabetes and vascular disease: a new international trial.
The prevalence of diabetes is increasing, particularly in developing regions of the world. The social and economic consequences of this disease and its complications are enormous. We discuss the scope and implications of the increasing burden of diabetes and describe the rationale and design of a new international study examining blood pressure lowering and glucose control interventions aimed at reducing the risk of vascular complications in people with type 2 diabetes. This study is the first large-scale randomized trial in diabetes to include participants from both lower- and higher-income regions of the world.
Patel
Anushka
A
International Coordinating Centre for ADVANCE, Institute for International Health, University of Sydney, PO Box 576, Newtown, New South Wales 2042, Australia. apatel@iih.usyd.edu.au
Chalmers
John
J
Chaturvedi
Vivek
V
Currie
Rochelle
R
Monaghan
Helen
H
Neal
Bruce
B
D000959:Antihypertensive Agents / Q000627:therapeutic use; D003906:Developing Countries; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000453:epidemiology; D003925:Diabetic Angiopathies / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D005907:Gliclazide / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007391:International Cooperation; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
D000959:Antihypertensive Agents; D007004:Hypoglycemic Agents; D005907:Gliclazide