Synthesis and structure of [Zn(OMe)(L)] x [Zn(OH)(L)] x 2(BPh4), L = cis,cis-1,3,5-tris[(E,E)-3-(2-furyl)acrylideneamino]cyclohexane: structural models of carbonic anhydrase and liver alcohol dehydrogenase.
Direct reaction of [Zn(OH)(L)]+, L = cis,cis-1,3,5-tris[(E,E)-3-(2-furyl)acrylideneamino]cyclohexane, with methanol gives a mixture of the starting material and [Zn(OMe)(L)]+; structural analysis of the complexes shows that they are models of reactive intermediates in the catalytic cycles of the zinc enzymes carbonic anhydrase and liver alcohol dehydrogenase.
Cronin
Leroy
L
Department of Chemistry, The University of York, Heslington, York, UK YO10 5DD.
Walton
Paul H
PH
D000426:Alcohol Dehydrogenase / Q000138:chemical synthesis* / Q000737:chemistry; D002256:Carbonic Anhydrases / Q000138:chemical synthesis* / Q000737:chemistry; D008099:Liver / Q000201:enzymology*; D008958:Models, Molecular; D015394:Molecular Structure
D000426:Alcohol Dehydrogenase; D002256:Carbonic Anhydrases