[On the "receptor" mechanism of the effect of biologically active substances in ultra low concentrations].
On the basis of antioxidant (alpha-tocopherol and phenosan potassium salt) and peptide (thyroliberin) effects on the lipid peroxide oxidation (LPO) and lipid structural parameters of the endoplasmic reticulum membranes in wide concentration range (10(-20)-10(-4) mol/l) in vitro the possibility concerning a proposed role of "super-affine" receptors in the mechanism of biologically active substances (BAS) action in ultra low doses (ULD) is discussed. Because these substances modulate investigated processes in the membranes which have not ordinarily receptors the conclusion about availability of non-receptor component in the mechanism of BAS effect in ULD and a low probability of "super-affine" receptor existence has been done.
Pal'mina
N P
NP
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119991 Russia. npalm@sky.chph.ras.ru
Kledova
L V
LV
Pankova
T V
TV
Gaintseva
V D
VD
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D007425:Intracellular Membranes / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D008051:Lipid Bilayers; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000166:cytology / Q000187:drug effects; D008315:Malondialdehyde / Q000032:analysis / Q000378:metabolism; D051379:Mice; D010666:Phenylpropionates / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D014783:Viscosity; D024502:alpha-Tocopherol / Q000494:pharmacology*
D000975:Antioxidants; D008051:Lipid Bilayers; D010666:Phenylpropionates; D008315:Malondialdehyde; D013973:Thyrotropin-Releasing Hormone; D024502:alpha-Tocopherol; C047854:fenozan