Hypoxic preconditioning reduces apoptosis in a rat model of immature brain hypoxia-ischaemia.
Hypoxic events are common in newborns but their consequences on brain development have not been demonstrated. It has been reported that in newborn animal models of cerebral hypoxic-ischaemic insult, short-term hypoxia before the insult completely prevented brain damage. The mechanisms of this brain tolerance have not been fully elucidated. Using a rat model of hypoxic preconditioning at day 6 followed by carotid ligation and hypoxic insult at day 7, we found a decrease in the number of apoptotic cells 24 and 48 h after the insult in the striatum, hippocampus and cortex. We demonstrated here that regulation of apoptotic cell death is one of the mechanisms involved in tolerance to hypoxia-ischaemia induced by hypoxic preconditioning.
Cantagrel
Sylvain
S
INSERM U 316, UFR des Sciences Pharmaceutiques, Tours, France. chalon@univ-tours.fr
Krier
Catherine
C
Ducrocq
Sarah
S
Bodard
Sylvie
S
Payen
Valérie
V
Laugier
Jean
J
Guilloteau
Denis
D
Chalon
Sylvie
S
D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis; D001921:Brain / Q000098:blood supply* / Q000473:pathology; D020925:Hypoxia-Ischemia, Brain / Q000401:mortality / Q000473:pathology*; D019194:Ischemic Preconditioning; D051381:Rats; D017208:Rats, Wistar