Human parvovirus B19 infection during the inactive stage of systemic lupus erythematosus.
A 42-year-old woman with systemic lupus erythematosus (SLE) had an episode of fever, arthralgia and anemia. In order to treat the suspected activation of SLE, the daily dose of steroid was increased, however, the anemia progressed and pancytopenia developed. Both IgM anti-B19 antibodies to human parvovirus B19 (B19) and B19 DNA were positive, and bone marrow analysis revealed pure red cell aplasia with giant proerythroblasts. High dose gamma globulin was administered and the daily dose of steroid was tapered, resulting in the improvement of her condition. B19 infection should be ruled out in cases with reactivation of autoimmune diseases.
Suzuki
Takashiro
T
Department of Internal Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-cho, Aoba-ku, Sendai 980-8574.
Saito
Shinichiro
S
Hirabayashi
Yasuhiko
Y
Harigae
Hideo
H
Ishii
Tomonori
T
Kodera
Takao
T
Fujii
Hiroshi
H
Munakata
Yasuhiko
Y
Sasaki
Takeshi
T
D000328:Adult; D001707:Biopsy, Needle; D001854:Bone Marrow Cells / Q000473:pathology*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D010322:Parvoviridae Infections / Q000150:complications / Q000175:diagnosis*; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D011239:Prednisolone / Q000627:therapeutic use; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome; D005719:gamma-Globulins / Q000627:therapeutic use
D005719:gamma-Globulins; D011239:Prednisolone