Rh(I)-catalyzed direct ortho-alkenylation of aromatic ketimines with alkynes and its application to the synthesis of isoquinoline derivatives.
[reaction: see text] Novel synthetic methods of both ortho-alkenylated aromatic ketones and isoquinoline derivatives have been developed through the Rh(I)-catalyzed direct ortho-alkenylation of common aromatic ketimines with alkynes. Furthermore, a highly efficient one-pot synthesis of isoquinoline derivatives was achieved by simply mixing aromatic ketone, benzylamine, and alkyne under a Rh(I) catalyst.
Lim
Sung-Gon
SG
Department of Chemistry, Yonsei Univeristy, Seoul 120-749, Korea.
Lee
Jun Hee
JH
Moon
Choong Woon
CW
Hong
Jun-Bae
JB
Jun
Chul-Ho
CH