Early diagnosis of cerebral infarction with near-infrared spectroscopy: an experimental study.
OBJECTIVE
To monitor the changes in the blood flow and blood-oxygen content in rat cerebral tissue with focal cerebral infarction using near-infrared spectroscopy (NIRS), so as to verify the value of NIRS in early diagnosis of cerebral infarction.


METHODS
Focal cerebral infarction models were established in 16 rats by injecting silk threads into the internal carotid artery. The bilateral blood flow and blood-oxygen content were monitored with NIRS in the models and also in 16 normal rats receiving saline injection to serve as blank control group.


RESULTS
Focal cerebral infarction in rats caused the decrement in blood-oxygen content and the increase in blood flow. No changes were observed in the control group after saline injection (P >0.05).


CONCLUSIONS
In the earlier stages of focal cerebral infarction, blood-oxygen decreases while blood flow increases in the infarcted area. NIRS provides real-time, non-invasive monitoring of blood volume and blood-oxygen content in the cerebral tissue.
Yao
Guo-jie
GJ
Department of Neurosurgery, Wuhan General Hospital of Guangzhou Command, Wuhan 430070, China.
Ma
Lian-ting
LT
Wu
Zuo-quan
ZQ
Qin
Shang-zhen
SZ
D000818:Animals; D001810:Blood Volume; D001921:Brain / Q000473:pathology; D002544:Cerebral Infarction / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005260:Female; D008297:Male; D010100:Oxygen / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D019265:Spectroscopy, Near-Infrared
D010100:Oxygen