title: Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis.
abstract: Wegener's granulomatosis (WG) is an autoimmune disease characterized by granulomatous lesions and a necrotizing vasculitis. Th1-type-cells lacking CD28 are expanded independent of age and immunosuppressive therapy in WG. To address their migratory properties of CD4(+)CD28(-) T-cells we studied the expression of the inducible inflammatory Th1-type chemokine receptor CCR5 in localized WG and generalized WG. Expansion of CD4(+)CD28(-) T-cells was more prominent in generalized WG compared to localized WG. In localized WG a larger fraction of CD4(+)CD28(-) T-cells displayed CCR5 expression compared to generalized WG. CCR5 expression was also higher in granulomatous lesions in localized WG. Higher levels of CCR5 expression on CD4(+)CD28(-) T-cells in localized WG may favor stronger CCR5-mediated recruitment of this T-cell subset into granulomatous lesions in localized WG. Expansion of Th-1-type CD4(+)CD28(-)CCR5(+) effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation.
authors.affiliation: Department of Rheumatology, University Hospital of Schleswig-Holstein, Campus Luebeck, and Rheumaklinik Bad Bramstedt, Ratzeburger Allee 160, 23538 Luebeck, Germany. lamprecht@rheuma-zentrum.de
authors.forename: Peter
authors.initials: P
authors.lastname: Lamprecht
authors.forename: Hilke
authors.initials: H
authors.lastname: Bruhl
authors.forename: Anika
authors.initials: A
authors.lastname: Erdmann
authors.forename: Konstanze
authors.initials: K
authors.lastname: Holl-Ulrich
authors.forename: Elena
authors.initials: E
authors.lastname: Csernok
authors.forename: Ulrike
authors.initials: U
authors.lastname: Seitzer
authors.forename: Matthias
authors.initials: M
authors.lastname: Mack
authors.forename: Alfred C
authors.initials: AC
authors.lastname: Feller
authors.forename: Eva
authors.initials: E
authors.lastname: Reinhold-Keller
authors.forename: Wolfgang L
authors.initials: WL
authors.lastname: Gross
authors.forename: Antje
authors.initials: A
authors.lastname: Muller
mesh_terms: D018106:CD28 Antigens; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D014890:Granulomatosis with Polyangiitis / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D019713:Receptors, CCR5 / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D018106:CD28 Antigens; D019713:Receptors, CCR5