Cooperative omega loops in cytochrome c: role in folding and function.
Hydrogen exchange experiments under slow exchange conditions show that an omega loop in cytochrome c (residues 40-57) acts as a cooperative unfolding/refolding unit under native conditions. This unit behavior accounts for an initial step on the unfolding pathway, a final step in refolding, and a number of other structural, functional and evolutionary properties.
Krishna
Mallela M G
MM
Department of Biochemistry and Biophysics, Johnson Research Foundation, University of Pennsylvania School of Medicine, 422 Curie Blvd, 1007 Stellar Chance Bldg, Philadelphia, PA 19104-6059, USA. mmg@hx2.med.upenn.edu
Lin
Yan
Y
Rumbley
Jon N
JN
Englander
S Walter
SW
D003574:Cytochrome c Group / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D009154:Mutation; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D013816:Thermodynamics
D003574:Cytochrome c Group; D006859:Hydrogen