title: Disruption of circadian coordination accelerates malignant growth in mice.
abstract: An animal model (mice B6D2F1) was developed to study the consequence of suprachiasmatic nuclei (SCN) destruction on tumor growth. SCN destruction abolished the rest-activity and body temperature rhythms and markedly altered the rhythms in serum corticosterone concentration and lymphocyte count. Tumor growth was faster in mice with lesioned SCN than in controls for both tumor models studied, Glasgow osteosarcoma (GOS) and pancreatic adenocarcinoma (P03). This shows that disruption of circadian coordination accelerates malignant growth in mice, suggesting that the host circadian clock controls tumor progression.
authors.affiliation: INSERM E 0654 "Chronotherapeutique des cancers" (Université Paris XI), Hôpital Paul Brousse, 94800, Villejuif, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Filipski
authors.forename: Verdun M
authors.initials: VM
authors.lastname: King
authors.forename: XiaoMei
authors.initials: X
authors.lastname: Li
authors.forename: Teresa G
authors.initials: TG
authors.lastname: Granda
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Mormont
authors.forename: Bruno
authors.initials: B
authors.lastname: Claustrat
authors.forename: Michael H
authors.initials: MH
authors.lastname: Hastings
authors.forename: Francis
authors.initials: F
authors.lastname: Lévi
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D001833:Body Temperature Regulation; D001859:Bone Neoplasms / Q000473:pathology*; D002455:Cell Division; D045744:Cell Line, Tumor / Q000637:transplantation; D002940:Circadian Rhythm; D003345:Corticosterone / Q000378:metabolism; D018450:Disease Progression; D008297:Male; D051379:Mice; D012516:Osteosarcoma / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000473:pathology*; D013493:Suprachiasmatic Nucleus / Q000293:injuries / Q000503:physiopathology
chemical_list: D003345:Corticosterone