Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats.
We examined the anxiolytic-like activity of (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) using the Vogel conflict drinking test, while antidepressant-like effects of this compound were evaluated using Porsolt's test. ACPT-I, a selective group III mGlu receptor agonist, produced a dose-dependent anticonflict effect after intrahippocampal injections and antidepressant-like effect in rats after intraventricular injections. These data suggest that selective group III mGlu receptor agonists may become a new class of anxiolytics and/or antidepressants.
Tatarczyńska
Ewa
E
Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 3 1-343 Kraków, Poland.
Pałucha
Agnieszka
A
Szewczyk
Bernadeta
B
Chojnacka-Wójcik
Ewa
E
Wierońska
Joanna
J
Pilc
Andrzej
A
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003517:Cyclopentanes / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*; D014233:Tricarboxylic Acids / Q000494:pharmacology* / Q000627:therapeutic use
C409063:1-aminocyclopentane-1,2,4-tricarboxylic acid; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D003517:Cyclopentanes; D018094:Receptors, Metabotropic Glutamate; D014233:Tricarboxylic Acids; C102718:metabotropic glutamate receptor 3