Polymorphism in transmembrane region of MICA gene and cholelithiasis.
OBJECTIVE
To study the significance of polymorphism of MHC class I chain-related gene A (MICA) gene in patients with cholelithiasis.


METHODS
Subjects included 170 unrelated adults (83 males) with cholelithiasis and 245 randomly selected unrelated adults (130 males) as controls. DNA was extracted from peripheral leukocytes and analyzed for polymorphism of 5 alleles (A4, A5, A5.1, A6 and A9) of the MICA gene.


RESULTS
There was no significant difference in phenotype, allele, and genotype frequencies of any of the 5 alleles between cholelithiasis patients and controls.


CONCLUSIONS
This study demonstrates that MICA alleles studied bear no relation to cholelithiasis.
Shih
Shou-Chuan
SC
Department of Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
Lee
Yann-Jinn
YJ
Liu
Hsin-Fu
HF
Dang
Ching-Wen
CW
Chang
Shih-Chuan
SC
Lin
Shee-Chan
SC
Kao
Chin-Roa
CR
D044466:Asian People / Q000235:genetics; D002769:Cholelithiasis / Q000235:genetics*; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D011897:Random Allocation
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A