Effect of camphor/cyclodextrin complexation on the stability of O/W/O multiple emulsions.
Camphor (CA) encapsulation in oil/water/oil multiple emulsions prepared with cyclodextrin disturbs the emulsifier potential of alpha- and beta-natural cyclodextrins (CD). It was suggested that the size and geometrical fit between the CD cavity and CA could induce CD/CA complex formation in place of emulsifier formation leading to perturbation of emulsion stability. The complexation between CA and alpha-, beta- or gamma-CD in solution in the presence of oil phase are confirmed by phase-solubility diagrams, circular dichroism and 1H NMR. Furthermore, in order to mimic the emulsion system, CD/CA/soybean oil ternary dispersions were prepared to observe the complexation behavior of alpha-, beta- or gamma-CD/CA by circular dichroism. X-ray diffraction on emulsion samples prepared with alpha- and beta-CD confirms that the precipitates observed in emulsions are probably composed of crystals of CD/CA complexes. A preliminary study of the interaction between drug and CD before the formulation seems indispensable to prevent the risk of incompatibility.
Yu
Shan-Chen
SC
UMR CNRS 8612, Faculté de Pharmacie, Université Paris-Sud, 5 rue JB Clément, 92296 Cédex, Châtenay-Malabry, France.
Bochot
Amélie
A
Bas
Geneviève Le
GL
Chéron
Monique
M
Mahuteau
Jacqueline
J
Grossiord
Jean-Louis
JL
Seiller
Monique
M
Duchêne
Dominique
D
D002164:Camphor / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002942:Circular Dichroism; D003460:Crystallization; D003505:Cyclodextrins / Q000737:chemistry*; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D012995:Solubility; D013024:Soybean Oil; D013501:Surface-Active Agents; D014867:Water; D014961:X-Ray Diffraction; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; D047408:gamma-Cyclodextrins
D003505:Cyclodextrins; D004655:Emulsions; D013501:Surface-Active Agents; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; D047408:gamma-Cyclodextrins; D014867:Water; D002164:Camphor; D013024:Soybean Oil; C031215:betadex; C023792:gamma-cyclodextrin; C032613:alpha-cyclodextrin