Prodromal and early epileptic seizures in acute stroke: does higher serum cholesterol protect?
In a case-control study, patients (n = 43/3,628) presenting seizures <1 week before (n = 6), < or =3 hours after (n = 26), and 3 to 24 hours after (n = 11) a first-ever stroke were studied. On multivariate analysis, they were characterized by lower levels of serum cholesterol (5.86 +/- 0.51 vs 6.34 +/- 0.58; p < 0.0001). Mortality and functional outcome at discharge were not influenced. Early poststroke seizures occur mainly during the critical 3-hour window for thrombolysis. Hypercholesterolemia appears to protect against seizures and cerebral ischemia.
Devuyst
G
G
Service de Neurologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. Gerald.Devuyst@chuv.hospvd.ch
Karapanayiotides
T
T
Hottinger
I
I
Van Melle
G
G
Bogousslavsky
J
J
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001925:Brain Damage, Chronic / Q000209:etiology / Q000517:prevention & control; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood*; D003244:Consciousness Disorders / Q000097:blood / Q000209:etiology; D004827:Epilepsy / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000097:blood / Q000150:complications*; D013997:Time Factors
D002784:Cholesterol