Bovine lactoferrin inhibits adenovirus infection by interacting with viral structural polypeptides.
We recently demonstrated that lactoferrin, an antimicrobial glycoprotein, can inhibit adenovirus infection by competing for common glycosaminoglycan receptors. This study further characterizes the antiadenovirus activity of the protein, thus demonstrating that lactoferrin neutralizes infection by binding to adenovirus particles and that its targets are viral III and IIIa structural polypeptides.
Pietrantoni
Agostina
A
Department of Ultrastructure, Istituto Superiore di Sanità, Rome, Italy.
Di Biase
Assunta Maria
AM
Tinari
Antonella
A
Marchetti
Magda
M
Valenti
Piera
P
Seganti
Lucilla
L
Superti
Fabiana
F
D000256:Adenoviridae / Q000737:chemistry / Q000187:drug effects* / Q000648:ultrastructure; D000258:Adenovirus Infections, Human / Q000188:drug therapy*; D000818:Animals; D000956:Antigens, Viral / Q000096:biosynthesis / Q000235:genetics; D001710:Biotin / Q000737:chemistry; D002417:Cattle; D004591:Electrophoresis, Polyacrylamide Gel; D004770:Enterovirus / Q000737:chemistry / Q000187:drug effects / Q000648:ultrastructure; D007781:Lactoferrin / Q000494:pharmacology / Q000627:therapeutic use*; D008854:Microscopy, Electron; D010455:Peptides / Q000737:chemistry / Q000187:drug effects*; D014407:Tumor Cells, Cultured
D000956:Antigens, Viral; D010455:Peptides; D001710:Biotin; D007781:Lactoferrin