In vivo antimalarial activity of Vernonia amygdalina.
Extracts from the leaves and root bark of Vernonia amygdalina are assessed for antimalarial activity against drug-sensitive Plasmodium berghei in mice. A standard inoculum of 1 x 10(7) infected erythrocytes is used, and leaf and root-bark extracts of 500 mg/kg, 250 mg/kg or 125 mg/kg are used in a four-day suppression test and a Rane test of established infection. Leaf extract produced 67% suppression of parasitaemia in the four-day test, while root-bark extract produced 53.5% suppression. These results are significant when compared to a placebo (P<0.001).
Abosi
Anthonia O
AO
Department of Biological Sciences, Faculty of Science, PO Box 70050, University of Botswana, Gaborone, Botswana. tonia603@hotmail.com
Raseroka
Benjamin H
BH
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use*; D010962:Plasmodium berghei; D016019:Survival Analysis; D035741:Vernonia
D000962:Antimalarials; D010936:Plant Extracts