title: High frequency of simultaneous sensitivity to Disperse Orange 3 in patients with positive patch tests to para-phenylenediamine.
abstract: Cross-sensitization between para-phenylenediamine (PPD) and Disperse Orange 3 (DO3), among other textile dyes, has frequently been reported. We evaluated the frequency of simultaneous patch test reactions to PPD and a range of textile dyes. Retrospectively, we studied 128 patients who were patch test positive to PPD and who had also been tested to textile dyes. The dyes that most commonly also reacted were DO3 (46.1%) followed by Disperse Yellow 3 (21.9%). 80% of 55 patients who had a + + or stronger reaction to PPD also reacted to DO3. Dyes that were least likely also to react were Bismarck Brown (0%), Naphthol AS (1.06%), Disperse Yellow 9 (1.06%), Disperse Blue 3 (1.56%) and Disperse Red 11 (2.13%). We interpreted the simultaneous patch test reactions to PPD and DO3 as due either to cross-sensitivity proper, or to metabolic conversion of textile dyes in the skin to PPD.
authors.affiliation: St John's Institute of Dermatology, St Thomas' Hospital, London, UK. agtj_2000@yahoo.com
authors.forename: Anthony T-J
authors.initials: AT
authors.lastname: Goon
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Gilmour
authors.forename: David A
authors.initials: DA
authors.lastname: Basketter
authors.forename: Ian R
authors.initials: IR
authors.lastname: White
authors.forename: Richard J G
authors.initials: RJ
authors.lastname: Rycroft
authors.forename: John P
authors.initials: JP
authors.lastname: McFadden
mesh_terms: D000485:Allergens / Q000009:adverse effects*; D001391:Azo Compounds / Q000009:adverse effects*; D004396:Coloring Agents / Q000009:adverse effects*; D003429:Cross Reactions; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology*; D004739:England / Q000453:epidemiology; D006801:Humans; D010328:Patch Tests; D010655:Phenylenediamines / Q000009:adverse effects*; D012189:Retrospective Studies
chemical_list: D000485:Allergens; D001391:Azo Compounds; D004396:Coloring Agents; D010655:Phenylenediamines; C041259:Disperse Orange 3; C029728:4-phenylenediamine