Different risk relations with smoking for non-small-cell lung cancer: comparison of TP53 and TP73 genotypes.
BACKGROUND
The association between TP53/TP73 gene polymorphisms and tobacco smoking was evaluated with regard to risk of non-small cell lung cancer (NSCLC).


METHODS
A case-control study with 192 histologically confirmed NSCLC cases and 241 non-cancer controls was conducted. Subjects were genotyped for TP53 Arg72Pro and TP73 G4C14 to A4T14 polymorphisms by PCR-based methods. Risk and interactions were assessed as odds ratios (ORs) and 95% confidence intervals (CIs).


RESULTS
The analyses according to TP53 genotypes for the risk of tobacco smoking illustrated that risk with heavy smoking was much higher for subjects with the TP53 ProPro genotype (OR: 16.4, 95% CI 1.77-151.7) as compared with those with TP53 ArgArg/ArgPro (3.36, 1.69-6.68). Similar analyses for TP73 genotypes did not show any differences for NSCLC risk.


CONCLUSIONS
A risk relation of heavy smoking for the NSCLC is suggested with the TP53 but not the TP73 polymorphism.
Hiraki
Akio
A
Department of Respiratory Medicine, National Sanyo Hospital, Yamaguchi, Japan.
Matsuo
Keitari
K
Hamajima
Nobuyuki
N
Ito
Hidemi
H
Hatooka
Shunzo
S
Suyama
Motokazu
M
Mitsudomi
Tetsuya
T
Tajima
Kazuo
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins; D005260:Female; D016147:Genes, Tumor Suppressor; D016158:Genes, p53; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins