Treadmill exercise suppresses diabetes-induced increment of neuropeptide Y expression in the hypothalamus of rats.
Diabetes mellitus is a metabolic disorder with serious sequelae in humans. Hyperphagia is a characteristic symptom of diabetes and is a central nervous system-mediated disorder. Neuropeptide Y (NPY) is a 36-amino-acid peptide and is concentrated in the hypothalamus which is an appetite-regulating area. NPY is known to stimulate appetite and decrease energy expenditure. In the present study, the effect of treadmill exercise on the hypothalamic NPY expression in rats with streptozotocin (STZ)-induced diabetes was investigated via immunohistochemistry. Enhanced NPY expression in the paraventricular nucleus and arcuate nucleus was observed in the STZ-induced diabetic rats. Treadmill exercise suppressed a diabetes-induced increase of NPY expression. The present results suggest the possibility that treadmill exercise inhibits diabetes-induced increment of the desire for food.
Shin
Mal Soon
MS
Kohwang Medical Research Institute, Kyung Hee University, Seoul, South Korea.
Kim
Hong
H
Chang
Hyun Kyung
HK
Lee
Taeck Hyun
TH
Jang
Mi Hyeon
MH
Shin
Min Chul
MC
Lim
Baek Vin
BV
Lee
Hee Hyuk
HH
Kim
Young Pyo
YP
Yoon
Jin Hwan
JH
Jeong
Il Gyu
IG
Kim
Chang Ju
CJ
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005080:Exercise Test; D007031:Hypothalamus / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley
D009478:Neuropeptide Y