Capillary electrophoresis for the determination of organic acidurias in body fluids: a review.
A systematic review of the literature on capillary electrophoresis applied to short chain organic acid analysis in body fluids has been conducted with special interest on those acids related to inborn errors of metabolism. The technique is briefly described, as well as the choice of the main analytical parameters: sample pre-treatment, polarity, capillary type, background electrolyte, and detection. The applications described in the literature are listed and the main features of the technique are discussed.
García
Antonia
A
Facultad de CC Experimentales y de la Salud, Universidad San Pablo-CEU, Boadilla del Monte, Madrid, Spain.
Barbas
Coral
C
D002264:Carboxylic Acids / Q000652:urine*; D019075:Electrophoresis, Capillary / Q000379:methods*; D005977:Glutarates / Q000652:urine; D006801:Humans; D007231:Infant, Newborn; D007773:Lactates / Q000652:urine; D019344:Lactic Acid / Q000652:urine; D008661:Metabolism, Inborn Errors / Q000652:urine; D008764:Methylmalonic Acid / Q000652:urine; D013056:Spectrophotometry, Ultraviolet / Q000295:instrumentation / Q000379:methods; D013997:Time Factors
D002264:Carboxylic Acids; D005977:Glutarates; D007773:Lactates; D019344:Lactic Acid; D008764:Methylmalonic Acid; C035736:glutaric acid