title: Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism.
abstract: Alcoholism is a disease that runs in families and results at least in part from genetic risk factors. The Collaborative Study on the Genetics of Alcoholism (COGA) is a Federally funded effort to identify and characterize those genetic factors. The study involves more than 1,000 alcoholic subjects and their families, with researchers conducting comprehensive psychological, physiological, electrophysiological, and genetic analyses of the participants. These analyses have identified several traits, or phenotypes, that appear to be genetically determined, such as the presence of alcohol dependence, the level of response to alcohol, the presence of coexisting depression, or the maximum number of drinks a person consumes per occasion. Genetic analyses have identified regions on several chromosomes that are associated with these phenotypes and need to be studied further.
authors.affiliation: Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: Laura Jean
authors.initials: LJ
authors.lastname: Bierut
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Saccone
authors.forename: John P
authors.initials: JP
authors.lastname: Rice
authors.forename: Alison
authors.initials: A
authors.lastname: Goate
authors.forename: Tatiana
authors.initials: T
authors.lastname: Foroud
authors.forename: Howard
authors.initials: H
authors.lastname: Edenberg
authors.forename: Laura
authors.initials: L
authors.lastname: Almasy
authors.forename: P Michael
authors.initials: PM
authors.lastname: Conneally
authors.forename: Raymond
authors.initials: R
authors.lastname: Crowe
authors.forename: Victor
authors.initials: V
authors.lastname: Hesselbrock
authors.forename: T K
authors.initials: TK
authors.lastname: Li
authors.forename: John
authors.initials: J
authors.lastname: Nurnberger
authors.forename: Bernice
authors.initials: B
authors.lastname: Porjesz
authors.forename: Marc A
authors.initials: MA
authors.lastname: Schuckit
authors.forename: Jay
authors.initials: J
authors.lastname: Tischfield
authors.forename: Henri
authors.initials: H
authors.lastname: Begleiter
authors.forename: Theodore
authors.initials: T
authors.lastname: Reich
mesh_terms: D000437:Alcoholism / Q000175:diagnosis / Q000235:genetics*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004569:Electroencephalography; D020022:Genetic Predisposition to Disease; D006801:Humans; D008967:Molecular Biology / Q000379:methods; D010641:Phenotype