title: [Molecular-biological markers as prognostic factors in breast cancer of I-IIA stage].
abstract: The study of molecular-biological markers for prediction of recurrence-free survival in breast cancer stage I-IIA demonstrates that high expression of thymidilate synthetase and high maximal density of microvessels are prognostically effective and that the prognosis is influenced by expression of both Bcl-2 and Bax. Low recurrence-free survival was observed in Bcl-2-/Bax patients (31%, median 44 months) while such survival was high in Bcl-2+/Bax patients (86%, median was not reached). The findings can be used for prognostication of a breast cancer clinical course.
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, 115478, Moscow.
authors.forename: E V
authors.initials: EV
authors.lastname: Stepanova
authors.forename: E I
authors.initials: EI
authors.lastname: Zagrekova
authors.forename: V D
authors.initials: VD
authors.lastname: Ermilova
authors.forename: A D
authors.initials: AD
authors.lastname: Turbin
authors.forename: N N
authors.initials: NN
authors.lastname: Petrovichev
authors.forename: I V
authors.initials: IV
authors.lastname: Vysotskaia
authors.forename: Zh N
authors.initials: ZhN
authors.lastname: Dbar
authors.forename: N V
authors.initials: NV
authors.lastname: Pashchenko
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Baryshnikov
authors.forename: M R
authors.initials: MR
authors.lastname: Lichinitser
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D001943:Breast Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D018275:Carcinoma, Lobular / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; D011518:Proto-Oncogene Proteins