Application of the Suzuki-Miyaura cross-coupling reaction for the modification of phenylalanine peptides.
We have demonstrated an exceptionally simple and a useful methodology for modification of unusual phenylalanine peptides by adapting the building block approach using the Suzuki-Miyaura cross-coupling reaction as a key step. This strategy gave a good overall yield of various modified tri- and pentapeptides that may be useful to prepare various biologically active peptides in a short period of time.
Kotha
Sambasivarao
S
Department of Chemistry, Indian Institute of Technology-Bombay, Mumbai, 400 076, India. srk@chem.iitb.ac.in
Lahiri
Kakali
K
D020650:Combinatorial Chemistry Techniques; D003432:Cross-Linking Reagents / Q000737:chemistry*; D015195:Drug Design; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010649:Phenylalanine / Q000737:chemistry*
D003432:Cross-Linking Reagents; D010455:Peptides; D010649:Phenylalanine