title: Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues.
abstract: An array of 4-(aryl or indolyl)pyrrolo[3,4-c]carbazole-1,3-diones (open analogues of indolocarbazole alkaloids), 10-(aryl or indolyl)pyrrolo[3,4-b]carbazole-1,3-diones, and different derivatives have been prepared using a Diels-Alder plus Fischer indolization approach and tested as cytotoxic agents. Some representative compounds display interesting cytotoxic profiles.
authors.affiliation: Laboratorio de Qui;mica Orgánica y Farmacéutica, Facultad de Farmacia, 37007, Salamanca, Spain. escab@usal.es
authors.forename: Esther
authors.initials: E
authors.lastname: Caballero
authors.forename: Marta
authors.initials: M
authors.lastname: Adeva
authors.forename: Suzanne
authors.initials: S
authors.lastname: Calderón
authors.forename: Heidi
authors.initials: H
authors.lastname: Sahagún
authors.forename: Fernando
authors.initials: F
authors.lastname: Tomé
authors.forename: Manuel
authors.initials: M
authors.lastname: Medarde
authors.forename: José Luis
authors.initials: JL
authors.lastname: Fernández
authors.forename: Miguel
authors.initials: M
authors.lastname: López-Lázaro
authors.forename: Maria Jesús
authors.initials: MJ
authors.lastname: Ayuso
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure
chemical_list: D000470:Alkaloids