The targets of nephritogenic antibodies in systemic autoimmune disorders.
In situ formation of immune complexes is a well recognized mechanism of renal injury in systemic autoimmune disorders. The identification of intrinsic renal antigens that are targets of nephritogenic antibodies is a field of active investigation. Recently, two proteins expressed in the kidney have been characterized as renal antigens. Alpha-actinin, an actin-binding protein localized in glomerular podocytes, is the major target of nephritogenic anti-DNA antibodies. Alpha-enolase, a glycolytic enzyme, is a target of nephritogenic anti-DNA and non-anti-DNA antibodies.
Migliorini
P
P
Clinical Immunology Unit, Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy. p.migliorini@med.unipi.it
Pratesi
F
F
Bongiorni
F
F
Moscato
S
S
Scavuzzo
M
M
Bombardieri
S
S
D000185:Actinin / Q000276:immunology*; D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D051379:Mice; D009393:Nephritis / Q000276:immunology*; D010751:Phosphopyruvate Hydratase / Q000276:immunology*
D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D000185:Actinin; D010751:Phosphopyruvate Hydratase