title: Rate-decreasing effects of the atypical neuroleptic risperidone attenuated by conditions of reinforcement in a woman with mental retardation.
abstract: Effects of two doses of risperidone on the performance of a matching task under tangible reinforcement and nonreinforcement conditions were measured in a woman with mental retardation. In both conditions, time to complete the task increased and response rates decreased under two doses of risperidone. Accuracy was generally unchanged. These changes were much smaller in the tangible reinforcement condition; thus, reinforcement seemed to protect performance from the rate-decreasing effects of risperidone.
authors.affiliation: University of Kansas, 67357, USA.
authors.forename: J Helen
authors.initials: JH
authors.lastname: Yoo
authors.forename: Dean C
authors.initials: DC
authors.lastname: Williams
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Napolitano
authors.forename: Robert T
authors.initials: RT
authors.lastname: Peyton
authors.forename: Donald M
authors.initials: DM
authors.lastname: Baer
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Schroeder
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001288:Attention / Q000187:drug effects*; D001321:Autistic Disorder / Q000188:drug therapy* / Q000523:psychology; D001521:Behavior Therapy / Q000379:methods*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D004193:Discrimination Learning / Q000187:drug effects*; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy* / Q000523:psychology; D010364:Pattern Recognition, Visual / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012055:Reinforcement Schedule; D018967:Risperidone / Q000009:adverse effects* / Q000627:therapeutic use; D014040:Token Economy
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone