title: Clinical implications of DES.
abstract: Once prescribed to pregnant women to prevent risk of spontaneous abortion, diethylstilbestrol (DES) is now associated with an increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. This article will summarize the potential long-term health implications of DES, the role of nurse practitioners in identifying exposed individuals, and proper clinical management.
authors.affiliation: University of Wisconsin-Madison, USA.
authors.forename: Kelly
authors.initials: K
authors.lastname: Kruse
authors.forename: Diane
authors.initials: D
authors.lastname: Lauver
authors.forename: Karen
authors.initials: K
authors.lastname: Hanson
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000175:diagnosis / Q000209:etiology*; D000022:Abortion, Spontaneous / Q000188:drug therapy; D018262:Adenocarcinoma, Clear Cell / Q000139:chemically induced / Q000175:diagnosis; D000293:Adolescent; D000328:Adult; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007246:Infertility / Q000139:chemically induced; D008297:Male; D008487:Medical History Taking / Q000379:methods; D010353:Patient Education as Topic / Q000379:methods; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D011297:Prenatal Exposure Delayed Effects; D014565:Urogenital Neoplasms / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D004968:Estrogens, Non-Steroidal; D004054:Diethylstilbestrol