title: [Pyoderma gangrenosum and orbital pseudotumor].
abstract: Pyoderma gangrenosum belongs to the chronic, neutrophilic and necrotic dermatoses. These very painful, inflammable and purulent skin-ulcers often arise after injury or surgical intervention. About half of the patients suffer from systemic disease, for example hematological, gastrointestinal or rheumatic diseases. Our report includes a 77-year-old female with a multilocular emergence of pyoderma gangrenosum following surgery for an orbital pseudotumor. An additional lesion was detected on her anterior neck. Because the possibility of wound-infection was suspected, the lesion was treated locally and with a systemic antibiotic therapy. After this treatment the condition of the wound deteriorated. Upon dermatological examination, pyoderma gangrenosum was identified and a immunosuppressive therapy with corticosteroids and cyclosporin was initiated. As a result of this treatment the lesion healed slowly--with the formation of typical, atrophic and reticular scars. A connection between the pyoderma gangrenosum and the orbital pseudotumor can, on the basis of similar clinical and structural characteristics, not be excluded. A related disease was not diagnosed in this patient. Recurrence can be predicted in patients who have had skin injuries, therefore strict observation is required.
authors.affiliation: Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie der Martin-Luther-Universität, Halle-Wittenberg.
authors.forename: C
authors.initials: C
authors.lastname: Welzel
authors.forename: M
authors.initials: M
authors.lastname: Bloching
authors.forename: S
authors.initials: S
authors.lastname: Born
authors.forename: A
authors.initials: A
authors.lastname: Berghaus
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D001706:Biopsy; D016572:Cyclosporine / Q000008:administration & dosage; D018450:Disease Progression; D004318:Doxycycline / Q000008:administration & dosage / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D009915:Orbit / Q000473:pathology / Q000601:surgery; D016727:Orbital Pseudotumor / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000175:diagnosis* / Q000188:drug therapy; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D017511:Pyoderma Gangrenosum / Q000175:diagnosis* / Q000188:drug therapy; D012008:Recurrence; D012535:Scalp / Q000473:pathology; D012867:Skin / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone; D004318:Doxycycline