Human V5 demonstrated by magnetoencephalography using random dot kinematograms of different coherence levels.
To investigate the cortical mechanisms for motion perception in human V5, we measured visual evoked magnetic fields in response to random dot kinematograms (RDKs) of three different coherence levels (50, 70 and 100%) using a 122-channel whole-head magnetometer. As the coherence level increased, the peak amplitude measured by the root mean square (RMS) of the local response increased significantly (7.4+/-1.0, 9.5+/-1.5 and 15.5+/-3.2 fT/cm on the right, 6.4+/-0.3, 7.8+/-0.7 and 12.5+/-0.9 fT/cm on the left; for the coherence level of 50, 70 and 100%, respectively). There was no significant difference between the hemispheres. As for the peak latency, there was no significant difference in terms of coherence levels or hemispheres. The response was localized posterior to the junction of the ascending limb of the inferior temporal and lateral occipital sulci (human V5). These findings indicate that processing of global motion in terms of the synchronized portion correlates well with the response amplitude but not with its latency. Thus, we could estimate the magnetic responses of human V5 non-invasively by presenting different coherence levels of the visual motion stimuli. Hemispheric laterality was recognized, although the dominant side varied among subjects.
Nakamura
Hajime
H
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawahara Machi, Shougoin Sakyo Kyoto City Kyoto, Kyoto 606-8507, Japan.
Kashii
Satoshi
S
Nagamine
Takashi
T
Matsui
Yoshie
Y
Hashimoto
Tadashi
T
Honda
Yoshihito
Y
Shibasaki
Hiroshi
H
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D004585:Electrooculography / Q000379:methods; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007697:Kinesics; D008279:Magnetic Resonance Imaging / Q000379:methods; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D009039:Motion Perception / Q000502:physiology*; D010775:Photic Stimulation; D011897:Random Allocation; D011930:Reaction Time