Effects of sleep on pain-related somatosensory evoked magnetic fields in humans.
We investigated the effects of sleep on pain-related somatosensory evoked magnetic fields (SEFs) following painful electrical stimulation to identify the mechanisms generating them in both fast A-beta fibers relating to touch and slow A-delta fibers relating to pain. While the subjects were awake, non-painful and painful electrical stimulations were applied, and while asleep, painful stimulation was applied to the left index finger. During awake, five components (1M-5M) were identified following both non-painful and painful stimulation, but the 4M and 5M at around 70-100 ms and 140-180 ms, respectively, were significantly enhanced following painful stimulation. During sleep, 1M and 2M generated in the primary somatosensory cortex (SI) did not show a significant change, 3M in SI showed a slight but significant amplitude reduction, and 4M and 5M generated in both SI and the secondary somatosensory cortex (SII) were significantly decreased in amplitude or disappeared. The 4M and 5M are complicated components generated in SI and SII ascending through both A-beta fibers and A-delta fibers. They are specifically enhanced by painful stimulation due to an increase of signals ascending through A-delta fibers, and are markedly decreased during sleep, because they much involve cognitive function.
Wang
Xiaohong
X
Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, Japan. wangxh@nips.ac.jp
Inui
Koji
K
Qiu
Yunhai
Y
Hoshiyama
Minoru
M
Tran
Tuan Diep
TD
Nguyen
Thi Binh
TB
Kakigi
Ryusuke
R
D000328:Adult; D000704:Analysis of Variance; D004558:Electric Stimulation / Q000379:methods; D004574:Electromagnetic Fields; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D006801:Humans; D008297:Male; D010146:Pain / Q000503:physiopathology*; D012890:Sleep / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology*