From Eden to a hell of uniformity? Directed evolution in humans.
For the first time during evolution of life on this planet, a species has acquired the ability to direct its own genetic destiny. Following 200,000 years of evolution, modern man now has the technologies not only to eradicate genetic disease but also to prolong life and enhance desired physical and mental traits. These technologies include preimplantation diagnosis, cloning, and gene therapy in the germline on native chromosomes or by adding artificial ones. At first glance, we should all be in favor of eliminating genetic diseases and enhancing genetic traits. Evolutionary considerations, however, uncover hidden dangers and suggest caution against the total embracement of such actions. The first major concern is that the genome will never be a completely reliable crystal ball for predicting human phenotypes. This is especially true for predictions concerning the performance of alleles in future generations whose populations might be subjected to different environmental and social challenges. The second, and perhaps more important, concern is that the end result of germline intervention and genetic enhancement will likely lead to the impoverishment of gene variants in the human population and deprive us of one of our most valued assets for survival in the future, our genetic diversity.
Brosius
Jürgen
J
Institute of Experimental Pathology, ZMBE, University of Münster, Von-Esmarch-Str. 56, Münster, Germany. RNA.world@uni-muenster.de
D000483:Alleles; D019020:Directed Molecular Evolution / Q000009:adverse effects* / Q000941:ethics / Q000379:methods; D005260:Female; D024861:Genetic Enhancement; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D010641:Phenotype; D012098:Reproduction / Q000235:genetics