Contribution of peripheral NMDA receptors in craniofacial muscle nociception and edema formation.
Contribution of peripheral NMDA receptors in craniofacial muscle nociception and inflammation was examined. Nocifensive paw-shaking behavior following masseteric injection of mustard oil (MO) was quantified in lightly anesthetized rats. MK-801 (0.3 mg/kg) preadministered in the masseter muscle significantly reduced the peak and overall magnitude of the MO-induced noficensive behavior. The reduction was greater than that produced by the same dose of MK-801 given intravenously or in the biceps muscle. Rats were sacrificed 2 h later and masseter muscles dissected and weighed. The injected muscle was 27.29+/-6.7% heavier than the contralateral muscle. The weight difference was significantly less only in rats pretreated with masseteric MK-801. These data provide evidence that peripheral NMDA receptors play an important role in craniofacial muscle nociception and inflammation.
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Jin Y
JY
Department of Oral and Craniofacial Biological Sciences, University of Maryland Baltimore School of Dentistry, 666 W. Baltimore Street, 21201, Baltimore, MD, USA. jyr001@dental.umaryland.edu
D000818:Animals; D016291:Dizocilpine Maleate / Q000008:administration & dosage / Q000494:pharmacology; D004487:Edema / Q000503:physiopathology*; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008406:Masseter Muscle / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D009149:Mustard Plant; D009619:Nociceptors / Q000378:metabolism*; D010146:Pain / Q000503:physiopathology*; D010936:Plant Extracts / Q000494:pharmacology; D010938:Plant Oils; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*
D018691:Excitatory Amino Acid Antagonists; D010936:Plant Extracts; D010938:Plant Oils; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; C027793:mustard oil