Evaluation of glucose-6-phosphate dehydrogenase activity in two different ethnic groups using a kit employing the haemoglobin normalization procedure.
OBJECTIVE
Correct evaluation of Glucose-6-Phosphate Dehydrogenase (G-6-PD) activity of two ethnic groups using a fully quantitative kit with a simultaneous Hemoglobin Normalization (Hb Normalization) procedure.


METHODS
Two groups of mothers and their healthy full term newborns of Greek (n = 1.166) and Albanian (n = 818) origin were tested for their G-6-PD activity employing a direct normalization protocol.


RESULTS
Greek mothers and newborns showed a higher prevalence for G-6-PD deficiency as compared to those of Albanian origin. Males of G-6-PD deficient mothers confirmed the efficacy of the method.


CONCLUSIONS
A fully quantitative G-6-PD kit employing Hb Normalization is essential for the correct classification of G-6-PD activity, both in male and female subjects.
Reclos
George J
GJ
R and D Diagnostics Ltd., 41 El. Venizelou Street, 15561 Holargos, Greece. mail@rddiagnostics.com
Schulpis
Kleopatra H
KH
Gavrili
Stavroula
S
Vlachos
George
G
D000415:Albania / Q000208:ethnology; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood / Q000208:ethnology; D006115:Greece; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D008297:Male
D006454:Hemoglobins; D005954:Glucosephosphate Dehydrogenase