New molecular pathways in angiogenesis.
Angiogenesis has developed into a major area of cancer research. Recently, several newly identified signalling pathways have been shown to play a role in both normal and pathological (including tumour) angiogenesis. Several of the molecules involved in these pathways have potential as novel anti-cancer therapeutic targets including members of the ephrin/Eph receptor, Notch/delta, sprouty, hedgehog and roundabout/slit families. These developments are reviewed.
Sullivan
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Molecular Angiogenesis Laboratory, Cancer Research UK, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
Bicknell
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D036342:Ephrins / Q000494:pharmacology*; D053823:Hedgehog Proteins; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000494:pharmacology; D009369:Neoplasms / Q000235:genetics* / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000235:genetics*; D036081:Receptors, Eph Family / Q000502:physiology*; D051880:Receptors, Notch; D015398:Signal Transduction; D015534:Trans-Activators / Q000494:pharmacology
D036342:Ephrins; D053823:Hedgehog Proteins; D008024:Ligands; D008565:Membrane Proteins; D051880:Receptors, Notch; D015534:Trans-Activators; D036081:Receptors, Eph Family