Functional consequences of the glycophenotype of squamous epithelia--practical employment.
Squamous epithelia represent a morphologically and differentiation-dependent stratified tissue. The stem cells are located in the bulge region of hair follicles or in the basal layer of interfollicular epidermis and in the limbus of the cornea. This article summarizes the data about the glycobiological aspects of squamous epithelia cell differentiation under physiological as well as pathological conditions in relation to the function of this epithelial tissue. The entries about the LC, Merkel cells and melanocytes are also mentioned. The employment of the described data in the diagnostics of carcinomas derived from this type of epithelium as well as in the cell therapy of skin defects are shown.
Smetana
K
K
Charles University, 1st Faculty of Medicine, Institute of Anatomy, Prague, Czech Republic. Ksmet@1fl.cuni.cz
Plzák
J
J
Dvoránková
B
B
Holíková
Z
Z
D000373:Agglutinins / Q000737:chemistry; D000818:Animals; D002277:Carcinoma / Q000378:metabolism; D002454:Cell Differentiation; D003208:Concanavalin A / Q000494:pharmacology; D000078404:Epidermal Cells; D004848:Epithelium / Q000473:pathology*; D006801:Humans; D007515:Islets of Langerhans / Q000166:cytology; D037102:Lectins; D008544:Melanocytes / Q000378:metabolism; D018862:Merkel Cells / Q000378:metabolism; D008954:Models, Biological; D010641:Phenotype; D012867:Skin / Q000473:pathology
D000373:Agglutinins; D037102:Lectins; D003208:Concanavalin A