title: Exocrine pancreatic insufficiency as an end stage of pancreatitis in four dogs.
abstract: Chronic pancreatitis is a common cause of exocrine pancreatic insufficiency (EPI) in humans and cats but is rarely recognised in dogs in which pancreatic acinar atrophy (PAA) is reportedly more common. This paper describes four dogs which developed EPI secondary to pancreatitis. Two of the dogs also had diabetes mellitus which developed before EPI. One diabetic dog had concurrent hyperadrenocorticism and was euthanased five months after presentation; the other diabetic dog died 48 months after diagnosis. The remaining dogs were alive 78 and 57 months after diagnosis. The number of affected dogs was comparable to the number of cases of presumed PAA seen over the same time period in the same institution. Chronic pancreatitis may be a more common cause of EPI in dogs than previously assumed and may be under-recognised because of difficulties in diagnosis. The relative importance of chronic pancreatitis as a cause of canine diabetes mellitus remains to be ascertained.
authors.affiliation: Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES.
authors.forename: P J
authors.initials: PJ
authors.lastname: Watson
mesh_terms: D000681:Amylases / Q000097:blood; D000818:Animals; D016022:Case-Control Studies; D002908:Chronic Disease; D018450:Disease Progression; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D010188:Exocrine Pancreatic Insufficiency / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008049:Lipase / Q000097:blood; D008297:Male; D010179:Pancreas / Q000473:pathology*; D010195:Pancreatitis / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D011996:Records / Q000662:veterinary; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014357:Trypsin / Q000097:blood
chemical_list: D008049:Lipase; D000681:Amylases; D014357:Trypsin