title: [Investigation of the degradation behavior of different modified bovine pericardial in vitro].
abstract: Bovine pericardium is mainly composed of collagen which has many good properties of extracellular matrix. This in vitro study was performed to quantitatively investigate and compare the degradation behavior of the bovine pericardial, which were modified with different methods. The purpose is to find out one method that presents not only the degradation regularity of material but also minimum antigenicity, so that bovine pericardium can be used as a well degradable guide tissue regeneration material. The results of the experiments showed that the bovine pericardium treated with ethanol is more appreciated than that treated with epoxy cross-linking agent or glutaraldehyde. The mensuration of protein and special amino acid may be a useful base of constructing a mathematic model for further researches on the rate of degradation of bovine pericardium.
authors.affiliation: Department of Polymer Science and Engineering, Sichuan University, Chengdu 610065.
authors.forename: Qingrong
authors.initials: Q
authors.lastname: Wei
authors.forename: Changxiu
authors.initials: C
authors.lastname: Wan
authors.forename: Hongwei
authors.initials: H
authors.lastname: Yao
authors.forename: Tianquan
authors.initials: T
authors.lastname: Li
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Xiong
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D001705:Bioprosthesis; D002417:Cattle; D003432:Cross-Linking Reagents / Q000737:chemistry / Q000494:pharmacology*; D006909:Hydroxyproline / Q000032:analysis; D066298:In Vitro Techniques; D008422:Materials Testing; D010496:Pericardium / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D011474:Prosthesis Design; D011506:Proteins / Q000032:analysis; D013499:Surface Properties
chemical_list: D003432:Cross-Linking Reagents; D011506:Proteins; D006909:Hydroxyproline