Anti-mechanical allodynic effect of intrathecal and intracerebroventricular injection of orexin-A in the rat neuropathic pain model.
Orexin-A has been reported to produce an analgesic effect in the hot plate test and in the inflammatory pain models. In the present study, the authors examined the effect of orexin-A on the mechanical allodynia induced by partial sciatic nerve ligation (a model of neuropathic pain) in the rat. Partial sciatic nerve ligation is created by tight ligation of one-third or one-half of the right sciatic nerve. Orexin-A was administered intrathecally or intracerebroventricularly 7 days after a partial sciatic nerve injury. Either intrathecal or intracerebroventricular injection of orexin-A attenuated the level of mechanical allodynia induced by partial sciatic nerve ligation. These data suggest that either intrathecal or intracerebroventricular injection of orexin-A is a new therapeutic approach to treating mechanical allodynia caused by nerve injury.
Yamamoto
Tatsuo
T
Department of Anesthesiology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, 260-8670, Chiba, Japan. yamatat@med.m.chiba-u.ac.jp
Saito
Osamu
O
Shono
Koyo
K
Aoe
Tomohiko
T
Chiba
Tanemichi
T
D000818:Animals; D002352:Carrier Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D003251:Constriction, Pathologic; D004195:Disease Models, Animal; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D047908:Intracellular Signaling Peptides and Proteins; D008026:Ligation; D008297:Male; D009479:Neuropeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D000068797:Orexins; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D010523:Peripheral Nervous System Diseases / Q000150:complications*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000473:pathology; D014110:Touch
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins