title: Apical entry channels in calcium-transporting epithelia.
abstract: The identification of the apical calcium channels CaT1 and ECaC revealed the key molecular mechanisms underlying apical calcium entry in calcium-transporting epithelia. These channels are regulated directly or indirectly by vitamin D and dietary calcium and undergo feedback control by intracellular calcium, suggesting their rate-limiting roles in transcellular calcium transport.
authors.affiliation: Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Ji-Bin
authors.initials: JB
authors.lastname: Peng
authors.forename: Edward M
authors.initials: EM
authors.lastname: Brown
authors.forename: Matthias A
authors.initials: MA
authors.lastname: Hediger
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D050916:TRPV Cation Channels
chemical_list: D015220:Calcium Channels; D050916:TRPV Cation Channels; C492239:TRPV5 protein, human; C120776:TRPV6 channel; D002118:Calcium