Antiviral activity of N-benzoylphenylisoserinates of Lactarius sesquiterpenoid alcohols in vitro.
Cytotoxic, antiviral, antibacterial and antifungal properties of a new, originally synthesised group of compounds: the N-benzoylphenylisoserinates of sesquiterpenoid alcohols - derivatives of taxol and various sesquiterpenes of Lactarius origin were evaluated in vitro. Among 16 compounds tested, 6 decreased HSV-1 titres. Selectivity indices ranged from 13.9 to 31.7. No activity against RNA viruses (parainfluenza 3, Coxsackie B3, vesicular stomatitis virus, and encephalomyocarditis virus), bacteria: Escherichia coli, Proteus mirabilis, Staphylococcus aureus, Enterococcus faecium and Bacteroides fragilis and fungal strain of Candida albicans was detected.
Krawczyk
Ewa
E
Chair and Department of Medical Microbiology, Medical University of Warsaw, Poland. ewakrawczyk@gazeta.pl
Łuczak
Mirosław
M
Kobus
Mirosław
M
Bańka
Dariusz
D
Daniewski
Włodzimierz
W
D000363:Agaricales; D000438:Alcohols / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D012694:Serine / Q000031:analogs & derivatives* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000494:pharmacology*
D000438:Alcohols; D000998:Antiviral Agents; D012717:Sesquiterpenes; D012694:Serine