Mortality of atomic bomb survivors predicted from laboratory animals.
Exposure, pathology and mortality data for mice, dogs and humans were examined to determine whether accurate interspecies predictions of radiation-induced mortality could be achieved. The analyses revealed that (1) days of life lost per unit dose can be estimated for a species even without information on radiation effects in that species, and (2) accurate predictions of age-specific radiation-induced mortality in beagles and the atomic bomb survivors can be obtained from a dose-response model for comparably exposed mice. These findings illustrate the value of comparative mortality analyses and the relevance of animal data to the study of human health effects.
Carnes
Bruce A
BA
The Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma 73190, USA. bruce@src.uchicago.edu
Grahn
Douglas
D
Hoel
David
D
D000367:Age Factors; D000818:Animals; D001822:Body Burden; D003198:Computer Simulation; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008136:Longevity / Q000528:radiation effects; D008297:Male; D051379:Mice; D023421:Models, Animal; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced / Q000401:mortality*; D009689:Nuclear Warfare; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000401:mortality; D011874:Radiometry / Q000379:methods; D013045:Species Specificity; D016019:Survival Analysis; D015996:Survival Rate; D017741:Survivors