Idiopathic myelofibrosis with refractory massive ascites.
A 55-year-old woman presented with massive refractory ascites in the course of idiopathic myelofibrosis. The ascites was exudative, and a cytological examination revealed granulocytes of varying maturity, erythroblasts, and megakaryocytes with trisomy 8. The ascites was assumed to have developed from peritoneal extramedullary hematopoiesis. An abnormal karyotype in the cells in the ascitic fluid, which was the same abnormality as in peripheral blood, helped to prove extramedulary hematopoiesis in this case, which can be an aid in making a differential diagnosis in cases of ascites associated with myelofibrosis.
Yotsumoto
Mihoko
M
Second Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621.
Ishida
Fumihiro
F
Ito
Toshiro
T
Ueno
Mayumi
M
Kitano
Kiyoshi
K
Kiyosawa
Kendo
K
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001201:Ascites / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D001202:Ascitic Fluid / Q000166:cytology; D001707:Biopsy, Needle; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm; D017809:Fatal Outcome; D005260:Female; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D018570:Risk Assessment; D012720:Severity of Illness Index