title: Studies of murine systemic autoimmunity.
abstract: Systemic autoimmunity is an important clinical problem, offering a window into fundamental questions of self-nonself tolerance. We have used cellular immunology, serology, and immunopathology to approach several spontaneous mouse models. Although much remains to be done, a picture is emerging of pathological antigen-driven immune responses to self nuclear antigens, highly dependent on multiple genes, and susceptible to abnormalities of apoptosis.
authors.affiliation: University of Pennsylvania, Philadelphia, PA, USA. philipco@mail.upenn.edu
authors.forename: Philip L
authors.initials: PL
authors.lastname: Cohen
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology; D015551:Autoimmunity; D004195:Disease Models, Animal; D007108:Immune Tolerance; D008264:Macrophages / Q000276:immunology; D051379:Mice; D013312:Stress, Physiological / Q000276:immunology; D016159:Tumor Suppressor Protein p53 / Q000276:immunology
chemical_list: D016159:Tumor Suppressor Protein p53