title: Magnetic resonance studies of dissolving particulate solids.
abstract: Magnetic resonance methods have been used to elucidate the internal pore structure of particulate solids, in particular detergent tablets. Such information is essential to a comprehensive understanding of the dissolution characteristics of these materials and how this property is related to processing conditions during tablet formation. In particular 3-D images of porosity are produced and 2-D self-diffusion maps are acquired as a function of observation time, which enables pore size to be quantified as a function of position via the extracted surface-to-volume ratio of the pore space. These properties are determined as a function of processing parameters, in particular the compression force used in tablet formation.
authors.affiliation: Department of Chemical Engineering, University of Cambridge, Cambridge CB2 3RA, UK. mlj21@cheng.can.ac.uk
authors.forename: M L
authors.initials: ML
authors.lastname: Johns
authors.forename: L F
authors.initials: LF
authors.lastname: Gladden
mesh_terms: D003902:Detergents; D004058:Diffusion; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D016062:Porosity
chemical_list: D003902:Detergents