[Synchronizing effect of corticosterone's circadian rhythm on the DNA synthesis rate in the liver of the young rat].
Post-natal liver proliferation is synchronized by corticosterone circadian variation from the 21st day of life in rats. After tritiated thymidine injection, we compare the labelling index, the specific radioactivity of DNA, the DNA synthesis rate, the plasma corticosterone in un-rhythmed rats at day 15 and in rhythmed rats at day 25. No variation of these parameters is found during the 15th nycthemeron. During the 25th nycthemeron, the corticosterone circadian wave peaking at 18 h is followed by the circadian variations of the 3 proliferation parameters peaking at 24 h.
Barbason
H
H
Université de Liège, cancérologie expérimentale, rue Belle-Maison no 7, 4877, Olne, Belgique.
Fourré
F
F
Focan
C
C
D000818:Animals; D002940:Circadian Rhythm; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D004261:DNA Replication; D008099:Liver / Q000254:growth & development / Q000378:metabolism*; D051381:Rats
D003345:Corticosterone