title: Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins.
abstract: The saponin fraction from the flower buds of Panax notoginseng exhibited protective effect on liver injury induced by d-galactosamine and lipopolysaccharide. From the saponin fraction with hepatoprotective effect, five new dammarane-type triterpene saponins, notoginsenosides-O (1), -P (2), -Q (3), -S (4), and -T (5), were isolated together with nine known protopanaxadiol oligoglycosides. The structures of the new saponins were elucidated on the basis of chemical and physicochemical evidence. The principal dammarane-type triterpene saponins from the roots and flower buds of Panax notoginseng were found to show potent hepatoprotective effects.
authors.affiliation: Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. shoyaku@mb.kyoto-phu.ac.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Morikawa
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Kashima
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Ninomiya
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035264:Flowers / Q000737:chemistry; D005688:Galactosamine / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D012477:Salmonella enteritidis / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000097669:Dammaranes
chemical_list: D004365:Drugs, Chinese Herbal; D005688:Galactosamine; D008070:Lipopolysaccharides; D012503:Saponins; D014315:Triterpenes; D000097669:Dammaranes