Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease.
A common polymorphism of the gene encoding acyl-coenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P=0.03) and with low cerebrospinal fluid levels of cholesterol (P=0.005). This polymorphism of SOAT1 is also associated with reduced risk for Alzheimer's disease in ethnically distinct populations (P=0.0001, odds ratio: 0.6, 95% confidence interval 0.4-0.8).
Wollmer
M A
MA
Division of Psychiatry Research, University of Zürich, Switzerland.
Streffer
J R
JR
Tsolaki
M
M
Grimaldi
L M E
LM
Lütjohann
D
D
Thal
D
D
von Bergmann
K
K
Nitsch
R M
RM
Hock
C
C
Papassotiropoulos
A
A
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001921:Brain / Q000201:enzymology*; D002784:Cholesterol / Q000134:cerebrospinal fluid*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D002785:Sterol O-Acyltransferase / Q000235:genetics*
D016229:Amyloid beta-Peptides; D002784:Cholesterol; D002785:Sterol O-Acyltransferase