Identification of harman as the antibiotic compound produced by a tunicate-associated bacterium.
The alkaloid harman, previously reported from some marine invertebrates, was identified as the antibiotic substance of the tunicate-associated bacterium Enterococcus faecium. It exhibited antibacterial activity (MIC, 0.017 mM) against the ichthyopathogenic strain Vibrio anguillarum.
Aassila
H
H
Laboratoire de Biochimie Marine, Département de Biologie, Faculté des Sciences, Université Chouaib Doukkali, BP 20 El Jadida, Morocco.
Bourguet-Kondracki
M L
ML
Rifai
S
S
Fassouane
A
A
Guyot
M
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D016984:Enterococcus faecium / Q000302:isolation & purification / Q000378:metabolism*; D006247:Harmine / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D014561:Urochordata / Q000382:microbiology*; D014733:Vibrio / Q000187:drug effects
D000900:Anti-Bacterial Agents; D006247:Harmine; C005010:harman