Randomized clinical trial and economic analysis of four-layer compression bandaging for venous ulcers.
BACKGROUND
The aim of this study was to compare the cost-effectiveness of four-layer compression bandaging for venous leg ulcers with that of other available treatments.


METHODS
In this pragmatic trial, 200 patients with a venous leg ulcer were randomized either to four-layer bandaging (intervention group; n = 100) or to continue their usual system of care (control group; n = 100). The follow-up for each patient was 12 weeks. Analysis was by intention to treat; the main outcome measures were time to healing and cost to the health board per leg healed.


RESULTS
Baseline characteristics were well matched in the two groups. The Kaplan-Meier estimate of the healing rate at 3 months was 54 per cent with four-layer bandaging and 34 per cent in the control group. Throughout the 3 months, four-layer bandaging healed leg ulcers significantly earlier (P = 0.006). There was a significant reduction in the median cost per leg healed with four-layer bandaging (euro 210 versus euro 234; P = 0.040).


CONCLUSIONS
Four-layer bandaging is currently the most effective method of treating venous leg ulcers in a community setting.
O'Brien
J F
JF
Department of Vascular Surgery, Mid-Western Regional Hospital, Limerick, Ireland.
Grace
P A
PA
Perry
I J
IJ
Hannigan
A
A
Clarke Moloney
M
M
Burke
P E
PE
D000368:Aged; D001458:Bandages / Q000191:economics; D003362:Cost-Benefit Analysis; D005260:Female; D005500:Follow-Up Studies; D006295:Health Resources / Q000191:economics; D006801:Humans; D008297:Male; D014647:Varicose Ulcer / Q000191:economics / Q000503:physiopathology / Q000628:therapy*; D014945:Wound Healing / Q000502:physiology