[Effects of EGF/EGFR expression on atrophic gastritis in rats].
To investigate the epidermal growth factor(EGF) and epidermal growth factor receptor(EGFR) expression in atrophic gastritis in rats to explore the relationship between EGF and chronic atrophic gastritis(CAG).



The serum EGF and gastric mucosal, EGFR level were measured in 20 rats with CAG and 20 normal controls.



The average EGF level (0.149+/-0.020) microg/L and 80% positive rate of EGFR expression observed in CAG group were significantly higher than those in control group[(0.043+/-0.003) microg/L and 0%,P<0.01].



The study demonstrates an association of high levels of EGF and positive EGFR expression in CAG rats. Further studies are necessary to clarify whether EGF/EGFR play a significant role in the pathogenesis of CAG.
Cao
Qian
Q
The Sir Run Run Shaw Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310016, China.
Si
Jian-min
JM
Wu
Jia-guo
JG
D000818:Animals; D004815:Epidermal Growth Factor / Q000097:blood* / Q000502:physiology; D066246:ErbB Receptors / Q000032:analysis* / Q000502:physiology; D005753:Gastric Mucosa / Q000737:chemistry*; D005757:Gastritis, Atrophic / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D004815:Epidermal Growth Factor; D066246:ErbB Receptors