title: Patched 1 conditional null allele in mice.
abstract: The patched gene (Ptc) is a member of the hedgehog signaling pathway which plays a central role in the development of many invertebrate and vertebrate tissues. In addition, Ptc and a number of other pathway members are mutated in some common human cancers. Patched is the receptor for the hedgehog ligand and in the mouse ablation of the Ptc gene leads to developmental defects and an embryonic lethal phenotype. Here we describe a conditional Ptc allele in mice which will have utility for the temporospatial ablation of Ptc function.
authors.affiliation: Institute for Molecular Bioscience, University of Queensland, Brisbane Queensland, Australia.
authors.forename: Tammy
authors.initials: T
authors.lastname: Ellis
authors.forename: Ian
authors.initials: I
authors.lastname: Smyth
authors.forename: Emily
authors.initials: E
authors.lastname: Riley
authors.forename: Scott
authors.initials: S
authors.lastname: Graham
authors.forename: Kate
authors.initials: K
authors.lastname: Elliot
authors.forename: Monica
authors.initials: M
authors.lastname: Narang
authors.forename: Graham F
authors.initials: GF
authors.lastname: Kay
authors.forename: Carol
authors.initials: C
authors.lastname: Wicking
authors.forename: Brandon
authors.initials: B
authors.lastname: Wainwright
mesh_terms: D000483:Alleles; D000818:Animals; D015139:Blotting, Southern; D017931:DNA Primers; D020868:Gene Silencing; D018390:Gene Targeting; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000172:deficiency* / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011956:Receptors, Cell Surface
chemical_list: D017931:DNA Primers; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C000606236:PTCH1 protein, human; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; C000606240:Ptch1 protein, mouse; D011956:Receptors, Cell Surface