title: Proteomics approaches to elucidation of signal transduction pathways.
abstract: Recent applications have shown that proteomics can provide crucial new information regarding cellular signaling processes. Bottom-up and small-scale top-down proteomics approaches related to routine biochemical methods have become widely applied to identify new aspects of established signaling pathways. Top-down, global proteomics methods are developing rapidly and are beginning to deliver information on global integration of signaling processes that has been difficult to obtain with conventional approaches.
authors.affiliation: Centre for Molecular Medicine, Department of Medicine, University College London, 5 University Street, London, WC1E 6JJ, UK. j.godovac-zimmermann@ucl.ac.uk
authors.forename: Jasminka
authors.initials: J
authors.lastname: Godovac-Zimmermann
authors.forename: Larry R
authors.initials: LR
authors.lastname: Brown
mesh_terms: D066246:ErbB Receptors / Q000378:metabolism; D006801:Humans; D011499:Protein Processing, Post-Translational; D040901:Proteomics; D017466:Receptors, Endothelin / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D017466:Receptors, Endothelin; D066246:ErbB Receptors