title: A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori.
abstract: The synthesis and anti-Helicobacter pylori activity of a novel agent NE2001, 4-(4-methylbenzyl)-4'-[guanidinomethylbenzoyloxy] biphenyl-4-carboxylate hydrochloride, are described. NE2001 had a specific inhibitory effect on the growth of H. pylori preceded by the suppression DNA synthesis in the cell. The effects of NE2001 on RNA and protein syntheses in H. pylori were also examined.
authors.affiliation: Department of Biochemistry, Nanjing University, Nanjing 210093, PR China.
authors.forename: Ni
authors.initials: N
authors.lastname: Cheng
authors.forename: Jian-Shu
authors.initials: JS
authors.lastname: Xie
authors.forename: Min-Yue
authors.initials: MY
authors.lastname: Zhang
authors.forename: Chang
authors.initials: C
authors.lastname: Shu
authors.forename: De-Xu
authors.initials: DX
authors.lastname: Zhu
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D019791:Guanidine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: C484502:4-(4-methylbenzyl)-4'-(guanidinomethylbenzoyloxy) biphenyl-4-carboxylate hydrochloride; D000900:Anti-Bacterial Agents; D001713:Biphenyl Compounds; D019791:Guanidine