title: Hyaluronic acid prevents peripheral nerve adhesion.
abstract: The purpose of this study was to clarify the effectiveness of hyaluronic acid (HA) in the prevention of scar formation after neurolysis using a rabbit model. In the first stage, the left sciatic nerve was exposed and elevated along a 3 cm section. Then, the surface of the neural bed was coagulated using a bipolar coagulator. Finally, the sciatic nerve was replaced and fixed to the neural bed with 8/0 nylon sutures, and the wound was closed. In the second stage, the adherent sciatic nerve was re-exposed after 6 weeks. In the neurolysis group, a simple neurolysis was performed. In the HA group, the neurolysis was performed in a surgical field coated with HA from the beginning to the end of the operation. In the steroid group, methyl prednisolone acetate was infiltrated at the end of the neurolysis. In the third stage, electrophysiological, histological and biomechanical measurements were taken 6 weeks after the second stage. While there was no significant difference between the HA and the steroid groups, the electrophysiological functions of the HA and steroid groups were significantly better than that of the neurolysis group. Histology showed that the formation of intraneural and extraneural scar tissue was lowest in the HA group, followed by the steroid and neurolysis groups. The tensile strength required to strip the sciatic nerve from the neural bed of the HA group was significantly less than that of the neurolysis group. However, there was no significant difference between the steroid and neurolysis groups. In conclusion, HA effectively reduced scar formation after neurolysis.
authors.affiliation: Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Kanazawa 920-8641, Japan. seikei@kenroku.ipc.kanazawa-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: D
authors.initials: D
authors.lastname: Yamauchi
authors.forename: N
authors.initials: N
authors.lastname: Osamura
authors.forename: N
authors.initials: N
authors.lastname: Hagiwara
authors.forename: K
authors.initials: K
authors.lastname: Tomita
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D002921:Cicatrix / Q000517:prevention & control*; D004594:Electrophysiology; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D010523:Peripheral Nervous System Diseases / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D011817:Rabbits; D012584:Sciatic Nerve; D000267:Tissue Adhesions / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control
chemical_list: D000276:Adjuvants, Immunologic; D006820:Hyaluronic Acid