[New pharmacological treatment concepts for overactive bladder].
Muscarinic receptor antagonists such as oxybutynin, propiverine, tolterodine, or trospium are the basis of medical treatment for overactive bladder. While they are moderately efficacious, their use can be limited by adverse effects such as dry mouth. This has sparked the search for new treatment options. Vanilloid receptor agonists, tachykinin receptor antagonists, potassium channel openers, and beta(3)-adrenoceptor agonists are currently under investigation, but are unlikely to become clinically available in the next few years. Therefore, current attempts to optimize treatment focus on improvement of existing drugs by new pharmaceutical formulations. Indeed, extended release formulations of oxybutynin (not available in Germany) or tolterodine have demonstrated an improved tolerability in clinical studies which was accompanied by an efficacy at least equal to that of their standard formulations.
Michel
M C
MC
Abteilung Pharmakologie und Pharmakotherapie, Universität, Amsterdam, Netherlands. m.c.michel@amc.uva.nl
D058667:Adrenergic beta-3 Receptor Agonists; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D015507:Drugs, Investigational / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D018727:Muscarinic Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D009122:Muscle Hypertonia / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D015221:Potassium Channels / Q000187:drug effects; D011955:Receptors, Drug / Q000819:agonists; D018039:Receptors, Tachykinin / Q000037:antagonists & inhibitors; D016896:Treatment Outcome; D001750:Urinary Bladder, Neurogenic / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D014549:Urinary Incontinence / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology
D058667:Adrenergic beta-3 Receptor Agonists; D003692:Delayed-Action Preparations; D015507:Drugs, Investigational; D018727:Muscarinic Antagonists; D015221:Potassium Channels; D011955:Receptors, Drug; D018039:Receptors, Tachykinin