[Pulmonary alveolar proteinosis: a report of 2 cases, with literature review].
OBJECTIVE
To summarize and analyze the clinical manifestations of pulmonary alveolar proteinosis (PAP) and its treatment.


METHODS
Retrospective analysis of 2 cases with literature was reviewed.


RESULTS
PAP presented a protracted chronic clinical course with overt symptoms but few physical signs, distinct chest radiography, and was a benign process. It was manifested as primary or secondary pathological changes. Typical chest CT scan showed "map" or "cobble stone" changes. Clinically, PAP was characterized by its incompatibility between symptoms and signs, and also radiographic picture and physical signs. The examination of bronchoalveolar lavage fluid could be used to confirm the diagnosis of PAP with periodic acid-schiff staining and electro microscopic examination. Whole lung lavage was an efficient therapy for PAP.


CONCLUSIONS
It is very important for physicians to pay much more attention on the early diagnosis and treatment of pulmonary alveolar proteinosis.
Gao
Zhan-cheng
ZC
Department of Respiratory Medicine, People's Hospital, Peking University, Beijing 100044, China. zhangao@yahoo.com
Xue
Qing
Q
Xu
Yu
Y
Li
Yin-ping
YP
Shen
Dan-hua
DH
He
Quan-ying
QY
D006801:Humans; D008297:Male; D008875:Middle Aged; D011649:Pulmonary Alveolar Proteinosis / Q000175:diagnosis / Q000473:pathology; D012189:Retrospective Studies; D055815:Young Adult