title: Latex allergy and fruit cross-reaction in subjects who are nonatopic.
abstract: Since the first case reported in 1927, latex allergy has attracted the attention of allergists including its capacity to cross-react with fruits. To evaluate the frequency of sensitivity to some fruit allergens shown to cross-react with latex, we evaluated 82 patients (43 men and 39 women, aged between 18 and 45 years) with latex allergy. All patients underwent skin tests with various fruit extracts that potentially cross-react with latex. Only patients with negative prick tests successively underwent prick-by-prick tests with fresh fruits. Thirty-nine of 82 patients (47.5%) were found to have positive skin tests. Prick tests with fruit extracts were positive in 28 patients (kiwi, 21 patients; banana, 17 patients; avocado, 8 patients; and papaya, 3 patients), and the prick-by-prick test had positive results in 11 patients (kiwi, 7 patients; banana, 4 patients; and avocado, 3 patients). In our experience patients with latex allergy are at a high risk of sensitization to some fruits and they often develop allergic reactions, even severe ones, after eating them; for this reason fruit sensitization should be taken into consideration when investigating patients allergic to natural rubber latex.
authors.affiliation: School and Division of Allergy and Clinical Immunology, University of Messina, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Isola
authors.forename: Luisa
authors.initials: L
authors.lastname: Ricciardi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Saitta
authors.forename: Roberta
authors.initials: R
authors.lastname: Fedele
authors.forename: Letteria
authors.initials: L
authors.lastname: Mazzeo
authors.forename: Olga
authors.initials: O
authors.lastname: Fogliani
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Gangemi
authors.forename: Francesco
authors.initials: F
authors.lastname: Purello-D'Ambrosio
mesh_terms: D000328:Adult; D003429:Cross Reactions; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications / Q000453:epidemiology / Q000276:immunology; D005638:Fruit / Q000276:immunology*; D006801:Humans; D015994:Incidence; D020315:Latex Hypersensitivity / Q000150:complications / Q000276:immunology*; D008297:Male