Treating coagulopathy in trauma patients.
Coagulopathy in patients with severe trauma is related to platelet and coagulation factor loss, consumption, and dysfunction. It is exacerbated by dilution, acidosis, and hypothermia. Hemorrhage control, warming, and appropriate blood product support are lifesaving. Further improvements in hemorrhage control will save additional lives and resources.
Armand
Ray
R
Department of Pathology, University of Maryland Medical Center, Baltimore, MD 21201, USA.
Hess
John R
JR
D000138:Acidosis; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D001803:Blood Transfusion; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006438:Hemodilution; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007035:Hypothermia; D007668:Kidney / Q000293:injuries; D008099:Liver / Q000293:injuries; D014947:Wounds and Injuries / Q000150:complications*
D001779:Blood Coagulation Factors