title: Effects of heparin on liver fibrosis in patients with chronic hepatitis B.
abstract: OBJECTIVE
  To evaluate the effects of heparin on liver fibrosis in patients with chronic hepatitis B.
  
  
  METHODS
  Fifty-two cases under study were divided into two groups, group A and group B. The two groups were given regular treatment and heparin/low molecular weight heparin (LMWH) treatment respectively. Hepatic functions, serum hyaluronic acid (HA) and type IV collagen levels were measured before and after the treatment, and six cases were taken liver biopsy twice.
  
  
  RESULTS
  After treatment, hepatic functions became significantly better in both groups. Serum HA and type IV collagen levels in group B compared with group A, decreased significantly after treatment. Collagen proliferation also decreased in group B after treatment.
  
  
  CONCLUSIONS
  Heparin/LMWH can inhibit collagen proliferation in liver tissues with hepatitis B.
authors.affiliation: Center for Liver Diseases, Shandong Provincial Hospital, 342 Jing Wu Wei Qi Road, Jinan 250021, Shandong Province, China. sdshij@yahoo.com.cn
authors.forename: Jun
authors.initials: J
authors.lastname: Shi
authors.forename: Jing-Hua
authors.initials: JH
authors.lastname: Hao
authors.forename: Wan-Hua
authors.initials: WH
authors.lastname: Ren
authors.forename: Ju-Ren
authors.initials: JR
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000925:Anticoagulants / Q000008:administration & dosage*; D001391:Azo Compounds; D001663:Bilirubin / Q000097:blood; D024141:Collagen Type IV / Q000097:blood; D004396:Coloring Agents; D004801:Eosine Yellowish-(YS); D005260:Female; D006416:Hematoxylin; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000473:pathology; D022781:Hepatocytes / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D008297:Male; D008739:Methyl Green; D008854:Microscopy, Electron; D008875:Middle Aged
chemical_list: D000925:Anticoagulants; D001391:Azo Compounds; D024141:Collagen Type IV; D004396:Coloring Agents; D006495:Heparin, Low-Molecular-Weight; C017768:trichrome stain; D008739:Methyl Green; D006820:Hyaluronic Acid; D000410:Alanine Transaminase; D001663:Bilirubin; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin