title: In vitro evaluation of the cytocompatibility of a glass-lonomer cement sealer.
abstract: The purpose of this study was to evaluate the cytocompatibility of two different types of root canal sealers in cell culture. Human periodontal ligament cells were cultured with set materials from an experimental glass-ionomer cement sealer (KT-308) and a commercially available zinc oxide-eugenol-based sealer (Canals) for 1, 3, and 7 days. Cytotoxic effects were evaluated from the morphological changes under a light microscope. Canals induced severe degenerative alteration of human periodontal ligament cells. In contrast, human periodontal ligament cells adjacent to KT-308 showed normal morphology and growth during the culture period. These results suggest that the glass-ionomer cement sealer, KT-308, is cytocompatible and has good potential as a root canal sealer.
authors.affiliation: Department of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshimine
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Ogasawara
authors.forename: Y
authors.initials: Y
authors.lastname: Koishi
authors.forename: K
authors.initials: K
authors.lastname: Tanabe
authors.forename: I
authors.initials: I
authors.lastname: Hashiguchi
authors.forename: A
authors.initials: A
authors.lastname: Akamine
mesh_terms: D002478:Cells, Cultured / Q000187:drug effects; D005899:Glass Ionomer Cements / Q000633:toxicity*; D006801:Humans; D008422:Materials Testing; D010513:Periodontal Ligament / Q000166:cytology / Q000187:drug effects*; D012387:Root Canal Filling Materials / Q000633:toxicity*; D015035:Zinc Oxide-Eugenol Cement / Q000633:toxicity
chemical_list: D005899:Glass Ionomer Cements; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; C112894:canals sealer