Can the effects of clinical reperfusion fluids on platelet aggregation in vitro predict the effects of administration of such fluids in a clinical study ex vivo?
Reperfusion fluids are administered routinely during surgical operations and following trauma. Studies performed wholly in vitro have indicated effects of some fluids on haemostasis through inhibition of platelet aggregation. Recently we performed a study to further evaluate the effects of reperfusion studies in vitro and also a study in a clinical setting to determine the extent to which the results of in vitro experiments can be extrapolated to the clinical situation. The results indicate that a combination of homeostatic and trauma response mechanisms complicate the ability to extrapolate from the findings in vitro.
Evans
P A
PA
Accident and Emergency Department, Morriston Hospital, Swansea SA6 6NL, UK.
Crowhurst
E C
EC
Glenn
J A
JA
Davies
T
T
Heptinstall
S
S
D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008954:Models, Biological; D010952:Plasma Substitutes / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010979:Platelet Function Tests; D011237:Predictive Value of Tests; D015424:Reperfusion / Q000009:adverse effects*; D012996:Solutions / Q000494:pharmacology; D014947:Wounds and Injuries
D010952:Plasma Substitutes; D012996:Solutions