Impaired passive avoidance acquisition in Wistar rats after restraint/cold stress and/or stresscopin administration.
Stresscopin (SCP) and related peptides are new members of the corticotropin-releasing factor (CRF) peptide family that are selective ligands for CRF type 2 receptor; these ligands are essential for maintaining homeostasis after stress. SCP (i.p. injections) was tested on the passive avoidance learning task in stressed Wistar rats; it impaired the formation of memory trace. The retention performance deficit induced by SCP was comparable with the deficit induced by the stressor of restraint/cold. More profound impairment of avoidance response occurred following combined application of SCP and stressor. More specific actions of SCP can be expected from its studies with targeted intracerebral applications.
Klenerová
V
V
Department of Pharmacology, First Medical Faculty, Charles University, Prague, Czech Republic. Vera.Klenerova@LF1.cuni.cz
Kaminský
O
O
Sída
P
P
Hlinák
Z
Z
Krejcí
I
I
Hynie
S
S
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003080:Cold Temperature; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*; D054832:Urocortins
C426704:UCN3 protein, human; D054832:Urocortins; D003346:Corticotropin-Releasing Hormone