title: Alveolar soft-part sarcoma responding to interferon alpha-2b.
abstract: A 23-year-old woman with an alveolar soft-part sarcoma of her calf with pulmonary metastases unresponsive to chemotherapy is described. Interferon (IFN) alpha-2b induced an impressive tumour response still ongoing after IFN treatment had to be stopped because of a psychosis. An explanation of this effect is still speculative.
authors.affiliation: Department of Haematology/Medical Oncology, Onze Lieve Vrouwe Gasthuis, Eerste Oosterparkstraat 179, 1090 HM Amsterdam, The Netherlands. K.J.Roosendaal@olvg.nl
authors.forename: K J
authors.initials: KJ
authors.lastname: Roozendaal
authors.forename: B
authors.initials: B
authors.lastname: de Valk
authors.forename: J J A
authors.initials: JJ
authors.lastname: ten Velden
authors.forename: H J
authors.initials: HJ
authors.lastname: van der Woude
authors.forename: B B R
authors.initials: BB
authors.lastname: Kroon
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects / Q000494:pharmacology*; D011618:Psychotic Disorders / Q000209:etiology; D011994:Recombinant Proteins; D012509:Sarcoma / Q000188:drug therapy* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins