title: Intraocular pressure changes during laparoscopy in patients anesthetized with propofol total intravenous anesthesia versus isoflurane inhaled anesthesia.
abstract: We examined intraocular pressure (IOP) changes during gynecologic laparoscopy performed under either thiopental-isoflurane anesthesia or total IV propofol anesthesia. Forty adult women with no preexisting eye disease scheduled for gynecologic CO(2) insufflation laparoscopy were included in the study. Heart rate, mean arterial blood pressure, peak and plateau airway pressure, ETCO(2), and IOP (using a Schioetz tonometer) were measured at defined intervals during the procedure. IOP decreased significantly after the induction of anesthesia in both groups, and remained so throughout the procedure in the propofol group. In the isoflurane group, however, IOP was increased significantly above the preinduction level after pneumoperitoneum with head-down position. There was no correlation between IOP and blood pressure or airway pressure. In conclusion, propofol total IV anesthesia may be a better choice for laparoscopic surgery should control of IOP be a concern.
  
  
  CONCLUSIONS
  In this study, we examined the effect of two anesthetic techniques on the intraocular pressure changes during laparoscopic surgery in healthy subjects. Propofol IV anesthesia protected against increases in intraocular pressure with pneumoperitoneum and head-down position.
authors.affiliation: Departments of *Anesthesia and †Ophthalmology, Faculty of Medicine, King Faisal University, Dammam, Saudi Arabia.
authors.forename: Hany A
authors.initials: HA
authors.lastname: Mowafi
authors.forename: Abdulmohsin
authors.initials: A
authors.lastname: Al-Ghamdi
authors.forename: Adel
authors.initials: A
authors.lastname: Rushood
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D013509:Gynecologic Surgical Procedures; D018475:Head-Down Tilt; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D007530:Isoflurane; D010535:Laparoscopy; D008875:Middle Aged; D011028:Pneumoperitoneum, Artificial; D015742:Propofol
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D007530:Isoflurane; D015742:Propofol