Extreme loss of neurons in sporadic Creutzfeldt-Jakob disease with 14-3-3 protein in cerebrospinal fluid.
Spongiform changes and astrogliosis predominantly represent the classical neuropathological features of sporadic Creutzfeldt-Jakob disease (CJD). They are accompanied by neuronal loss, which is usually of moderate intensity, and by PrPsc plaques. We present sporadic CJD lasting 12 months, confirmed by 14-3-3 P, with almost complete loss of neurones in many grey structures of the brain.
Tabaka
Justyna
J
Department of Neurology, Pomeranian Medical University, Szczecin, Poland.
Nowacki
Przemysław
P
Stankiewicz
Jan
J
Wierzba-Bobrowicz
Teresa
T
D048948:14-3-3 Proteins; D000368:Aged; D001253:Astrocytes / Q000473:pathology; D002465:Cell Movement; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009410:Nerve Degeneration / Q000134:cerebrospinal fluid / Q000473:pathology; D009474:Neurons / Q000473:pathology*; D014446:Tyrosine 3-Monooxygenase / Q000134:cerebrospinal fluid*
D048948:14-3-3 Proteins; D014446:Tyrosine 3-Monooxygenase