COP9 signalosome: a provider of DNA building blocks.
In fission yeast, the COP9 signalosome is required to activate ribonucleotide reductase for DNA synthesis. This is mediated via the ubiquitin ligase Pcu4, activation of which leads to degradation of the scaffold protein Spd1, which anchors the small ribonucleotide reductase subunit in the nucleus away from the large subunit in the cytoplasm.
Nielsen
Olaf
O
Department of Genetics, Institute of Molecular Biology, University of Copenhagen, Øster Farimagsgade 2A, DK-1353 Copenhagen K, Denmark. onigen@biobase.dk
D000075686:COP9 Signalosome Complex; D002453:Cell Cycle / Q000502:physiology*; D044842:Cullin Proteins / Q000378:metabolism; D008954:Models, Biological; D046912:Multiprotein Complexes; D010447:Peptide Hydrolases; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D012264:Ribonucleotide Reductases / Q000378:metabolism*; D012568:Schizosaccharomyces; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
D044842:Cullin Proteins; D046912:Multiprotein Complexes; D011506:Proteins; D012264:Ribonucleotide Reductases; D044767:Ubiquitin-Protein Ligases; D010447:Peptide Hydrolases; D000075686:COP9 Signalosome Complex