Effects of traditional Chinese formulations on rat carotid artery injured by balloon endothelial denudation.
We examined the inhibitory effects of traditional Chinese formulations (TCFs: Kampo formulation in Japanese) on intimal thickening of the carotid artery injured by balloon endothelial denudation in rats. Among the eight TCFs examined oren-gedoku-to (huanglian-jiedu-tang in Chinese), choto-san (diao-teng-san), saiko-ka-ryukotsu-borei-to (chaihujia-longgu-muli-tang) and dai-joki-to (da-cheng-qi-tang) significantly inhibited the intimal thickening 7 days after denudation. These four TCFs also inhibited proliferation of vascular smooth muscle cells (VSMC), which may play a central role in the development of restenosis after balloon endothelial denudation. The present results suggest that further evaluation of these four TCFs as inhibitors of VSMC proliferation to prevent arteriosclerosis is warranted.
Chung
Hwa-Jin
HJ
Department of Pharmacognosy, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
Kim
Dong-Wook
DW
Maruyama
Ikuro
I
Tani
Tadato
T
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001835:Body Weight / Q000502:physiology; D020212:Carotid Artery Injuries / Q000188:drug therapy*; D016893:Carotid Stenosis / Q000188:drug therapy / Q000473:pathology; D002404:Catheterization; D002455:Cell Division / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000293:injuries*; D007202:Indicators and Reagents; D008165:Luminol; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects; D018809:Proliferating Cell Nuclear Antigen; D051381:Rats; D017208:Rats, Wistar; D062367:ortho-Aminobenzoates / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D007202:Indicators and Reagents; D018809:Proliferating Cell Nuclear Antigen; D062367:ortho-Aminobenzoates; D008165:Luminol; C012293:tranilast