[Study on the changes in endogenous oxidation agents and levels of anti-oxidation agents in patients with cerebral vascular disease].
OBJECTIVE
To investigate serum levels of endogenous oxidation agents, anti-oxidation agents and clinical significance in the patients with cerebral vascular disease (CVD).


METHODS
Using biochemical methods, the levels of serum nitric oxide (NO), nitric oxide synthase (NOS), malondialdehyde (MDA) and anti-oxidants vitamin E (VitE), vitamin C (VitC), superoxide dismutase (SOD) in 49 patients with cerebral hemorrhage (CH), 65 patients with cerebral infarction(CI) and 35 patients with other nervous system diseases and 34 healthy controls were determined.


RESULTS
In CH and CI groups, the levels of serum NO and MDA and the activity of serum NOS were significantly higher than that of the two other groups (P<0.05 or P<0.01). On the other hand, the patients with CH and CI had lower VitE, VitC levels and SOD activity than that of the two control groups (P<0.05 or P<0.01).


CONCLUSIONS
These findings suggest NO and NOS plays an important role in pathogenesis of cerebral damage after CH and CI. Determination of the concentrations of NO, VitE, VitC, MDA level, and NOS and SOD activity in serum can also help judge the seriousness and the course of the disease.
Chen
Jian-hua
JH
Department of Neurology Qiannan Prefecture Hospital, Duyun 558000, Guizhou, China.
Liu
Xiao-juan
XJ
Wang
Qi-chun
QC
Zeng
Hong
H
Jiang
Xian-ping
XP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D019001:Nitric Oxide Synthase / Q000097:blood*; D010084:Oxidation-Reduction; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D014810:Vitamin E; D009569:Nitric Oxide; D008315:Malondialdehyde; D019001:Nitric Oxide Synthase; D001205:Ascorbic Acid