[Cerebrovascular disease and diabetic patients with hypertension].
Diabetic patients have a higher incidence of stroke, especially cerebral infarction. Hypertension as well as aging and sex differences are recognized as a major factor for stroke. In addition, diabetes is likely to be accompanied by hypertension. Recently, many mega studies have reported that aggressive blood pressure reduction significantly reduced stroke. Therefore, the tighter control of blood pressure is required to prevent stroke in diabetic patients as compared with non-diabetic subjects. Desirable target pressure is less than 130/80 mmHg and the treatment in older patients should be almost the same as in younger patients, although blood reduction should be attempted safely and by a step. The use of ACE-inhibitor and/or Ca antagonist is recommended as first-line drugs for achieving it.
Kawamura
Takahiko
T
Department of Metabolism and Endocrine Internal Medicine, Chubu Rosai Hospital.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D048909:Diabetes Complications; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*; D012307:Risk Factors; D020521:Stroke / Q000209:etiology* / Q000517:prevention & control*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers