HFE genotype and transferrin saturation in the United States.
OBJECTIVE
Examine the penetrance (defined by high transferrin saturation [TS]) of C282Y and H63D in the U.S. population.


METHODS
5171 participants from the Third National Health and Nutrition Examination Survey, 1992 to 1994.


RESULTS
77.1% (95% confidence interval [CI], 2.3, 95.1) of men and 51.9% (95% CI, 0, 84.2) of women with C282Y homozygosity had high TS. The associations of H63D homozygosity with high TS were stronger in people aged 50 years or older than in younger persons. Among Mexican-Americans, simple H63D heterozygosity was associated with high TS.


CONCLUSIONS
The associations between HFE genotype and high TS may vary by sex, age, and ethnic group.
Cogswell
Mary E
ME
Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA.
Gallagher
Margaret L
ML
Steinberg
Karen K
KK
Caudill PhD
Samuel P
SP
Looker
Anne C
AC
Bowman
Barbara A
BA
Gunter
Elaine W
EW
Franks
Adele L
AL
Satten
Glen A
GA
Khoury
Muin J
MJ
Grummer-Strawn
Laurence M
LM
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005838:Genotype; D000071020:Hemochromatosis Protein; D006579:Heterozygote; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D015233:Models, Statistical; D016017:Odds Ratio; D014168:Transferrin / Q000235:genetics*; D014481:United States
C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D014168:Transferrin