title: In vitro antiplasmodial activity and cytotoxicity of ethnobotanically selected Ivorian plants.
abstract: Eight extracts from four Ivorian medicinal plants, traditionally used to treat malaria, were tested for their antiplasmodial activity in vitro by assessing their ability to inhibit the uptake of [3H]hypoxanthine into the Plasmodium falciparum K1 chloroquine-resistant strain. The most active extract was the methylene chloride extract of Anogeissus leiocarpus which exhibited an IC(50) value of 3.8 micro g/ml. Inhibition of the growth of Plasmodium falciparum was also observed with the methylene chloride extract of Cochlospermum planchonii and Microdesmis keayana as well as with both methylene chloride and methanolic extracts of Hymenocardia acida.
authors.affiliation: UFR des Sciences et Technologie des Aliments, Université d'Abobo-Adjamé, 02 BP 801 Abidjan 02, Ivory Coast.
authors.forename: Catherine
authors.initials: C
authors.lastname: Vonthron-Sénécheau
authors.forename: Bernard
authors.initials: B
authors.lastname: Weniger
authors.forename: Modibo
authors.initials: M
authors.lastname: Ouattara
authors.forename: Fezan Tra
authors.initials: FT
authors.lastname: Bi
authors.forename: Alphonse
authors.initials: A
authors.lastname: Kamenan
authors.forename: Annelise
authors.initials: A
authors.lastname: Lobstein
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
authors.forename: Robert
authors.initials: R
authors.lastname: Anton
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D031212:Bixaceae / Q000737:chemistry*; D002460:Cell Line; D029764:Combretaceae / Q000737:chemistry*; D007560:Cote d'Ivoire; D004351:Drug Resistance; D019665:Euphorbiaceae / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry; D008752:Methylene Chloride / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D051381:Rats
chemical_list: D000962:Antimalarials; D010936:Plant Extracts; D008752:Methylene Chloride; D000432:Methanol