title: Measurements of cerebral perfusion and arterial hemodynamics during visual stimulation using TURBO-TILT.
abstract: Estimation of cerebral blood flow (CBF) in functional perfusion imaging could benefit from a method capable of separating effects of arterial arrival time and trailing edge. To accomplish this, the transfer insensitive labeling technique (TILT) was combined with a train of 13 consecutive acquisitions, called TURBO-TILT. Visual activation maps obtained at 13 postlabeling delay times (TI) showed a spatial shift from regions surrounding the arterial vasculature at short TI to brain parenchyma at longer delay times. High baseline CBF and short arrival times were found for the voxels with maximum activation at short TI (<1200 ms), while CBF values (43 ml / 100 g tissue/min) and its increase upon activation (55%) at longer TI were in agreement with literature data on regional cerebral perfusion.
authors.affiliation: Department of Radiology, University Medical Center, Utrecht, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Hendrikse
authors.forename: Hanzhang
authors.initials: H
authors.lastname: Lu
authors.forename: Jeroen
authors.initials: J
authors.lastname: van der Grond
authors.forename: Peter C M
authors.initials: PC
authors.lastname: Van Zijl
authors.forename: Xavier
authors.initials: X
authors.lastname: Golay
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002536:Cerebral Arteries / Q000502:physiology; D002560:Cerebrovascular Circulation; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010775:Photic Stimulation