title: Subsurface skin renewal by treatment with a 1450-nm laser in combination with dynamic cooling.
abstract: A new nonablative laser device, Smoothbeam, has been under evaluation for nonablative wrinkle reduction in skin with minimal side effects. This device incorporates a laser at 1450-nm wavelength to heat the dermis and cryogen spray cooling to prevent epidermal damage. The thermal injury created is internal and imperceptible. The wound-healing response to this internal injury causes improvement in the appearance of skin wrinkles. Biopsies taken immediately after treatment showed mild residual thermal damage (RTD) at a depth range of 150 to 400 microm, which is the dermal zone where most solar elastosis resides. Biopsies from two months after treatment showed fibroplasia extending over a range of depths similar to the acute RTD zones. An improvement in wrinkle severity was noted on the treated side compared with the control side.
authors.affiliation: Candela Corporation, 530 Boston Post Road, Wayland, Massachusetts 01778, USA. dilip.paithankar@clzr1.com
authors.forename: Dilip Y
authors.initials: DY
authors.lastname: Paithankar
authors.forename: Joan M
authors.initials: JM
authors.lastname: Clifford
authors.forename: Bilal A
authors.initials: BA
authors.lastname: Saleh
authors.forename: E Victor
authors.initials: EV
authors.lastname: Ross
authors.forename: Christina A
authors.initials: CA
authors.lastname: Hardaway
authors.forename: David
authors.initials: D
authors.lastname: Barnette
mesh_terms: D001940:Breast / Q000473:pathology / Q000528:radiation effects; D002056:Burns / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D017679:Cryotherapy / Q000379:methods; D062109:Dermatologic Surgical Procedures; D020405:Dermis / Q000293:injuries / Q000473:pathology* / Q000528:radiation effects / Q000601:surgery*; D004817:Epidermis / Q000293:injuries / Q000473:pathology / Q000528:radiation effects; D006358:Hot Temperature / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D066298:In Vitro Techniques; D053685:Laser Therapy / Q000009:adverse effects / Q000379:methods*; D008954:Models, Biological; D015361:Rhytidoplasty / Q000379:methods*; D012867:Skin / Q000293:injuries / Q000473:pathology / Q000528:radiation effects; D015595:Skin Aging / Q000528:radiation effects*; D013813:Therapy, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome