title: Fine needle aspiration cytology in non-neoplastic non-toxic recurrent nodular goitre.
abstract: The aim of the study was to examine whether evaluation of anisokaryosis is helpful in the cytological diagnosis of focal lesions in non-toxic recurrent goitre (NRG) after thyroidectomy for non-malignant goitre. Karyometric analysis was performed in routine cytological smears obtained from 80 females: 40 with focal lesions in non-toxic primary goitre (NPG) and 40 with NRG (postoperative histopathological examination revealed nodular goitre in both groups in all cases). We found that the level of anisokaryosis was significantly (P<0.005) higher in NRG than in NPG. There were no significant differences between the two lesions, in cellular composition or thyroid follicular cell arrangement. Thus, isolated anisokaryosis, a feature of malignancy in patients without a prior thyroidectomy, has limited diagnostic value in recurrent goitre.
authors.affiliation: Department of Thyroidology, Institute of Endocrinology, Medical University of Łódź, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Słowińska-Klencka
authors.forename: M
authors.initials: M
authors.lastname: Klencki
authors.forename: S
authors.initials: S
authors.lastname: Sporny
authors.forename: A
authors.initials: A
authors.lastname: Lewiński
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D002467:Cell Nucleus / Q000000981:diagnostic imaging; D005260:Female; D006044:Goiter, Nodular / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D007620:Karyometry; D008875:Middle Aged; D012008:Recurrence; D013964:Thyroid Neoplasms / Q000175:diagnosis*; D014463:Ultrasonography