Salicylic acid: an old dog, new tricks, and staphylococcal disease.
Aspirin has been shown to cause a reduction in the virulence of Staphylococcus aureus-associated endocarditis. A new study reveals that salicylic acid, the major metabolite of aspirin, acts at the level of transcription to downregulate the production of fibrinogen, fibronectin, and alpha-hemolysin - virulence factors necessary for bacterial replication in host tissues and, now, potential therapeutic targets.
Herrmann
Mathias
M
Department of Bacteriology and Hygiene, Institute of Microbiology and Hygiene, Building 43, Kirrberger Street, 66421 Homburg/Saar, Germany. mathias.herrmann@uniklinik-saarland.de
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000382:microbiology; D006801:Humans; D008954:Models, Biological; D020156:Salicylic Acid / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000472:pathogenicity
D000900:Anti-Bacterial Agents; D020156:Salicylic Acid