title: MDR1 C3435T genetic polymorphism does not influence the response to antiretroviral therapy in drug-naive HIV-positive patients.
abstract: P-glycoprotein, a membrane-localized protein transporter, codified by the MDR1 gene, influences the response to pharmacological treatments, including antiretroviral drugs. MDR1 polymorphism C3435T is correlated with the functionality of the protein. We investigated the influence of this polymorphism in the reconstitution of the peripheral CD4 T cell pool in 149 drug-naive HIV-positive patients starting highly active antiretroviral therapy. The MDR1 C3435Tpolymorphism did not influence response to therapy, suggesting no disadvantages for individuals with a different genotype.
authors.affiliation: Department of Biomedical Sciences, University of Modena and Reggio Emilia School of Medicine, via Campi 287, 41100 Modena, Italy.
authors.forename: Milena
authors.initials: M
authors.lastname: Nasi
authors.forename: Vanni
authors.initials: V
authors.lastname: Borghi
authors.forename: Marcello
authors.initials: M
authors.lastname: Pinti
authors.forename: Cristian
authors.initials: C
authors.lastname: Bellodi
authors.forename: Enrico
authors.initials: E
authors.lastname: Lugli
authors.forename: Stefania
authors.initials: S
authors.lastname: Maffei
authors.forename: Leonarda
authors.initials: L
authors.lastname: Troiano
authors.forename: Luca
authors.initials: L
authors.lastname: Richeldi
authors.forename: Cristina
authors.initials: C
authors.lastname: Mussini
authors.forename: Roberto
authors.initials: R
authors.lastname: Esposito
authors.forename: Andrea
authors.initials: A
authors.lastname: Cossarizza
mesh_terms: D018791:CD4 Lymphocyte Count; D019450:Genes, MDR; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics* / Q000276:immunology; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D011110:Polymorphism, Genetic; D016896:Treatment Outcome
chemical_list: D017320:HIV Protease Inhibitors