title: Coronary-artery bypass surgery and the brain: persisting concerns.
abstract: Mortality after coronary-artery bypass surgery (CABS) has fallen steadily over recent years. Concern remains, however, about the effect of this surgery on the brain. The problem of brain damage after CABS is multifactorial, involving microembolism, disturbed perfusion, metabolic derangement, and inflammatory responses. Microemboli numbers have been linked to the likelihood of neuropsychological deterioration after surgery. Risk factors for cerebral changes after CABS include older age, gender, neurological disease, diabetes, and calcification of the aorta. These risk factors are important because, in comparison with the early 1990s, patients undergoing CABS are now older and tend to have a greater number of comorbid conditions. Changes in surgical technique, such as the introduction of arterial-line filters and membrane oxygenators, have led to a reduction of both microemboli and neuropsychological disturbance. However, the problem persists, prompting further studies on surgical technique and neuroprotective strategies.
authors.affiliation: Unit of Health Psychology, University College London Medical School, Middlesex Hospital, Mortimer Street, London, UK. S.Newman@ucl.ac.uk
authors.forename: Stanton P
authors.initials: SP
authors.lastname: Newman
authors.forename: Michael J G
authors.initials: MJ
authors.lastname: Harrison
mesh_terms: D001921:Brain / Q000473:pathology*; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000379:methods / Q000523:psychology*; D006801:Humans