How does a cell anchor and invade an organ?
In multicellular organisms, most cells are confined to a particular tissue. However, some cells invade organs during normal development and in diseases (e.g., angiogenesis and cancer). Recent studies reveal a fascinating step-by-step process in which specific vulval cells induce and attract a single gonadal cell to invade an epithelial tubular organ in order to connect the uterus to the vulva in C. elegans.
Podbilewicz
Benjamin
B
Department of Biology, Technion-Israel Institute of Technology, 32000, Haifa, Israel.
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D019070:Cell Lineage; D002465:Cell Movement / Q000235:genetics; D004848:Epithelium / Q000196:embryology; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006066:Gonads / Q000166:cytology / Q000196:embryology; D006918:Hydroxyurea / Q000494:pharmacology; D008954:Models, Biological; D009154:Mutation; D014599:Uterus / Q000196:embryology; D014844:Vulva / Q000196:embryology
D029742:Caenorhabditis elegans Proteins; D006918:Hydroxyurea