title: The impact of the new biology on radiation risks in space.
abstract: Radiation is considered to be one of three or four major hazards for personnel in space and has emerged as the most critical issue to be resolved for long-term missions, both orbital and interplanetary. Space habitats are stressful and dangerous environments. Health and medical consequences arising from microgravity, stress, and trauma include weakened immune systems, increased viral activity, and loss of bone mass. The greatest risks from radiation are generally assumed to be cancers and possibly damage to the central nervous system. Synergistic effects arising from the other environmental hazards along with abscopal and exogenic factors are likely. Space programs represent an exceptional opportunity for examining the biological consequences of low-dose exposures of humans to radiation at every level of progression. Although astronauts are a relatively small population, they are healthy, physically active volunteers who undergo extensive testing and medical examinations before, during, and after protracted exposures with periodic follow-up examinations. The radiation environments along with other hazards are likewise monitored and documented. Extensive international research programs are in progress. Seven years ago the U.S. National Aeronautics and Space Administration established the National Space Biomedical Research Institute through a cooperative agreement with a consortium of research and academic institutions in order to address radiation issues through a concerted, programmatic effort. Advanced technologies are rapidly being incorporated into these programs to determine the significance of new biological data and to evaluate the interplay among the different medical hazards. Programmatic in vivo and in vitro studies of the processes leading to carcinogenesis are in progress. Drugs and dietary supplements are being examined at the cellular and in vivo levels to assess their potential as dose-modifying agents. The infrastructure of this new approach, recent results, and research in progress are reviewed and discussed.
authors.affiliation: The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Division of Radiation Oncology, The Johns Hopkins University School of Medicine, The Harry and Jeanette Weinberg Building, Baltimore, MD 21231-2410, USA. diceljo@jhmi.edu
authors.forename: John F
authors.initials: JF
authors.lastname: Dicello
mesh_terms: D000047:Academies and Institutes / Q000458:organization & administration; D000818:Animals; D018480:Astronauts; D002490:Central Nervous System / Q000528:radiation effects; D003299:Cooperative Behavior; D003359:Cosmic Radiation / Q000009:adverse effects*; D004247:DNA / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005118:Extraterrestrial Environment; D006801:Humans; D007373:Interinstitutional Relations; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D016273:Occupational Exposure; D011832:Radiation Injuries / Q000209:etiology; D011835:Radiation Protection / Q000379:methods; D012107:Research Design; D018570:Risk Assessment / Q000379:methods*; D013026:Space Flight / Q000379:methods*; D014481:United States; D018557:United States National Aeronautics and Space Administration / Q000458:organization & administration
chemical_list: D004247:DNA