title: Cystocin, a novel antibiotic, produced by Streptomyces sp. GCA0001: biological activities.
abstract: Cystocin belongs to the class of nucleoside antibiotics from Streptomyces sp. GCA0001. Cystocin showed good activity against gram-positive bacteria, but showed less activity against the gram-negative bacteria. Cystocin exhibited about two to four folds higher activity than puromycin. Especially, cystocin shows relatively strong activity against Streptococcus strains. Cystocin shows quite potent antitumor activity against all of the cells tested showing IC50 values of 0.10 to 0.14 microg/mL. This in vitro result indicates that the cytotoxocity of cystocin is two ten folds more active than puromycin's.
authors.affiliation: Institute of Biomolecule Reconstruction, Sunmoon University, 100 Kalsanri, Tangjeongmyun, Asansi, Chungnam 336-840, Korea.
authors.forename: Hei Chan
authors.initials: HC
authors.lastname: Lee
authors.forename: Kwangkyoung
authors.initials: K
authors.lastname: Liou
authors.forename: Dae Hee
authors.initials: DH
authors.lastname: Kim
authors.forename: Sun-Yub
authors.initials: SY
authors.lastname: Kang
authors.forename: Jin-Suk
authors.initials: JS
authors.lastname: Woo
authors.forename: Jae Kyung
authors.initials: JK
authors.lastname: Sohng
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D003545:Cysteine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D011692:Puromycin Aminonucleoside / Q000737:chemistry / Q000494:pharmacology; D013302:Streptomyces / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; C483611:cystocin; D011692:Puromycin Aminonucleoside; D000241:Adenosine; D003545:Cysteine