[Cytotec: an effective drug for the induction of labor].
OBJECTIVE
Our purpose was to compare the safety and efficacy of intravaginal Cytotec versus Oxytocin for induction of labor.


METHODS
Two hundredth seventy six of patients with indications for induction of labor were assigned to receive either intravaginal Cytotec or Oxytocin. Cytotec were placed in the posterior vaginal fornix every three (3) hours with a potential maximum of six (6) doses. Oxytocin were administered to a standard protocol of our clinic.


RESULTS
Among those evaluated 138 received Cytotec and 137 received Oxytocin. The overage interval from start of induction to vaginal delivery was shorter in the Cytotec group (1332.4 +/- 846.5 min) than in the Oxytocin group (1523 +/- 705.6 min). There were no significant differences in the routes of delivery. 20.7% of the Cytotec treated patients and 28% of the Oxytocin treated patients required abdominal delivery.


CONCLUSIONS
Intravaginal administration of Cytotec appears to be as effective as Oxytocin labor induction.
Milchev
N
N
Kuzmanov
B
B
Terzhumanov
R
R
D000282:Administration, Intravaginal; D002585:Cesarean Section; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D016595:Misoprostol / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D010120:Oxytocics / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D010121:Oxytocin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D011247:Pregnancy; D011256:Pregnancy Outcome; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects
D010120:Oxytocics; D016595:Misoprostol; D010121:Oxytocin