[Therapeutic efficacy of combined application of lamivudine and bushen recipe in treating chronic hepatitis B and its influence on YMDD motif].
OBJECTIVE
To observe the effect of combined application of Lamivudine and Bushen recipe (BSR) in treating patients with chronic hepatitis B (CHB) and its influence on tyrosine-methionine-aspartate-aspartate (YMDD) motif.


METHODS
Eighty-eight patients of CHB with positive HBV-DNA were divided into 3 groups, Group A treated with Lamivudine, Group B treated with Lamivudine plus BSR1 and Group C treated with Lamivudine plus BSR2, the serum HBV-DNA, hepatic biological parameters and YMDD motif mutation were observed.


RESULTS
The positive rate of HBV-DNA (6.45%) and YMDD motif mutation (3.23%) in Group C were lower than those in Group A respectively, after 52 weeks treatment.


CONCLUSIONS
Combined application of Lamivudine and BSR could enhance the therapeutic effect in treating CHB to certain extent, and could reduce the mutation of YMDD motif.
Zhou
Fei
F
Affiliated Shuguang Hospital, Shanghai University of TCM, Shanghai 200021. zhoufeii@hotmail.com
Wang
Ling-tai
LT
Chen
Jian-jie
JJ
D000293:Adolescent; D000328:Adult; D020816:Amino Acid Motifs / Q000235:genetics*; D000998:Antiviral Agents / Q000627:therapeutic use; D017124:Conserved Sequence; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006515:Hepatitis B virus / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000188:drug therapy*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D008517:Phytotherapy
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D019259:Lamivudine