Self-expandable metallic stents for malignant duodenal obstruction caused by biliary tract cancer.
BACKGROUND
Malignant duodenal obstruction is a common event in patients with advanced biliary tract cancer. Because bypass surgery is accompanied by significant morbidity, self-expandable metallic stents have emerged as a possible alternative for palliation.


METHODS
Twenty patients with biliary tract cancer (7 gallbladder, 13 Klatskin tumors) and duodenal obstruction were treated with metallic stents at a single institution between 1999 and 2001. Survival, morbidity, and stent function were studied prospectively. The ability to eat was assessed by using a scoring system.


RESULTS
Stent placement was technically successful in all patients. An additional stent was required in 6 cases (4 occlusions, 2 dislocations). Median survival was 20.5 weeks; there was no treatment-related death. Twenty-eight biliary stent exchanges were performed in 13 (65%) patients. Erosive reflux esophagitis improved in 11 of 12 (92%) cases. After 4 weeks, all 17 surviving patients tolerated soft or solid food, whereas 13 of 17 (77%) tolerated a more solid diet (p < 0.001, gastric outlet obstruction scoring system). Twelve of 17 (71%) patients gained a median of 1.5 kg of body weight (p = 0.001). The median Karnofsky scale increased from 50% to 60% in 13 of 17 (77%) patients.


CONCLUSIONS
Self-expandable metallic stents are a safe, efficacious, and minimally invasive treatment option for palliation of patients with duodenal obstruction from biliary tract cancer. Technical complications can be managed endoscopically and the bile duct remains accessible for endoluminal treatment.
Schiefke
Ingolf
I
Department of Internal Medicine II, University of Leipzig, Germany.
Zabel-Langhennig
Alexander
A
Wiedmann
Marcus
M
Huster
Dominik
D
Witzigmann
Helmut
H
Mössner
Joachim
J
Berr
Frieder
F
Caca
Karel
K
D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000150:complications; D001661:Biliary Tract Neoplasms / Q000150:complications*; D004380:Duodenal Obstruction / Q000209:etiology / Q000628:therapy*; D004384:Duodenoscopy; D005706:Gallbladder Neoplasms / Q000150:complications; D005764:Gastroesophageal Reflux / Q000628:therapy; D006801:Humans; D018285:Klatskin Tumor / Q000150:complications; D008297:Male; D008670:Metals; D008875:Middle Aged; D010166:Palliative Care / Q000379:methods; D010778:Photochemotherapy; D011446:Prospective Studies; D011475:Prosthesis Failure; D015607:Stents / Q000009:adverse effects; D016896:Treatment Outcome
D008670:Metals