Nickel(0)-mediated sequential addition of carbon dioxide and aryl aldehydes into terminal allenes.
[reaction: see text] Nickel-mediated sequential addition of carbon dioxide and aryl aldehydes into terminal allenes is reported. The reaction proceeded in a diastereoselective manner to afford alpha-methylene-gamma-hydroxy carboxylic acids, which allowed stereoselective preparation of cis-beta, gamma-disubstituted alpha-methylene-gamma-lactones.
Takimoto
Masanori
M
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Kawamura
Mitsunobu
M
Mori
Miwako
M