title: Blunted metabolic response to SKF 82958 in the mesolimbic system following preweaning cocaine treatment.
abstract: This study examined glucose metabolic rates following dopamine D(1) agonist challenge in adult male rats pretreated with cocaine during postnatal days 11-20. Water-pretreated control rats showed a reliable decrease in glucose metabolism of rostral mesolimbic structures when challenged with SKF 82958 while cocaine-pretreated males did not. These data support the notion that cocaine exposure during the preweaning period dampens D(1) receptor-mediated function and that the mesolimbic system exhibits a selective vulnerability to early cocaine exposure.
authors.affiliation: Laboratory of Cerebral Metabolism, Department of Physiology/Pharmacology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Box #29, Brooklyn, NY 11203, USA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Melnick
authors.forename: Diana L
authors.initials: DL
authors.lastname: Dow-Edwards
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D008032:Limbic System / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D014886:Weaning
chemical_list: D001552:Benzazepines; D018491:Dopamine Agonists; D018765:Dopamine Uptake Inhibitors; C071262:SK&F 82958; D003042:Cocaine; D005947:Glucose