title: Polymorphism in transmembrane region of MICA gene and cholelithiasis.
abstract: OBJECTIVE
  To study the significance of polymorphism of MHC class I chain-related gene A (MICA) gene in patients with cholelithiasis.
  
  
  METHODS
  Subjects included 170 unrelated adults (83 males) with cholelithiasis and 245 randomly selected unrelated adults (130 males) as controls. DNA was extracted from peripheral leukocytes and analyzed for polymorphism of 5 alleles (A4, A5, A5.1, A6 and A9) of the MICA gene.
  
  
  RESULTS
  There was no significant difference in phenotype, allele, and genotype frequencies of any of the 5 alleles between cholelithiasis patients and controls.
  
  
  CONCLUSIONS
  This study demonstrates that MICA alleles studied bear no relation to cholelithiasis.
authors.affiliation: Department of Medicine, Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: Shou-Chuan
authors.initials: SC
authors.lastname: Shih
authors.forename: Yann-Jinn
authors.initials: YJ
authors.lastname: Lee
authors.forename: Hsin-Fu
authors.initials: HF
authors.lastname: Liu
authors.forename: Ching-Wen
authors.initials: CW
authors.lastname: Dang
authors.forename: Shih-Chuan
authors.initials: SC
authors.lastname: Chang
authors.forename: Shee-Chan
authors.initials: SC
authors.lastname: Lin
authors.forename: Chin-Roa
authors.initials: CR
authors.lastname: Kao
mesh_terms: D044466:Asian People / Q000235:genetics; D002769:Cholelithiasis / Q000235:genetics*; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D011897:Random Allocation
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A