title: Synthesis and partial characterization of hydrogels obtained via glutaraldehyde crosslinking of acetylated chitosan and of hyaluronan derivatives.
abstract: Hydrophilic networks based on functionalized hyaluronic acid and on partially acetylated chitosan, respectively, have been obtained. In the case of hyaluronic acid (HA), primary amino functionalities have been introduced along the polysaccharide chains. The ensuing derivatives, i.e., HA-lysine (HA-K), HA-diamino pentane (HA-DAP), and HA-glycine-lysine (HA-GK), have been characterized by high field NMR spectroscopy. NMR 2D-DOSY experiments have allowed us to optimize the purification procedure. Chitosan was made soluble in water by partial acetylation. Cross-linking reactions have been performed using glutaraldehyde. The obtained networks have been qualitatively characterized by means of (13)C CP-MAS NMR technique. The hydrogels have been characterized also in terms of water uptake.
authors.affiliation: Department of Chemistry, University "La Sapienza", Rome, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Crescenzi
authors.forename: Andrea
authors.initials: A
authors.lastname: Francescangeli
authors.forename: Anna
authors.initials: A
authors.lastname: Taglienti
authors.forename: Donatella
authors.initials: D
authors.lastname: Capitani
authors.forename: Luisa
authors.initials: L
authors.lastname: Mannina
mesh_terms: D000107:Acetylation; D002240:Carbohydrate Sequence; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry*; D048271:Chitosan; D003432:Cross-Linking Reagents / Q000737:chemistry*; D003956:Dialysis; D005976:Glutaral / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D014783:Viscosity
chemical_list: D003432:Cross-Linking Reagents; D020100:Hydrogels; D002686:Chitin; D006820:Hyaluronic Acid; D048271:Chitosan; D005976:Glutaral