Cholesterol homeostasis and function in neurons of the central nervous system.
Cholesterol is a multifaceted molecule. First, it serves as an essential membrane component, as a cofactor for signaling molecules and as a precursor for steroid hormones; second, its synthesis, intercellular transport and intracellular distribution present a logistic tour de force requiring hundreds of cellular components, and third, it plays a crucial role in major human diseases. Despite intense research on this molecule, its metabolism in the central nervous system and its role in neuronal development and function are not well understood. Here I summarize recent results and hypotheses about how neurons maintain their cholesterol level and how cholesterol influences the establishment and maintenance of synaptic connections.
Pfrieger
F W
FW
Max-Planck/CNRS Group, UPR 2356, Centre de Neurochimie, 5, rue Blaise Pascal, 67084 Strasbourg Cedex, France. fw-pfrieger@gmx.de
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001693:Biological Transport, Active; D002490:Central Nervous System / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D008959:Models, Neurological; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism
D002784:Cholesterol