Transmission of HIV type 1 through blood transfusion from an antibody-negative/p24 antigen-negative donor.
Transmission of HIV through transfusion occurred in a 78-year-old male after receiving red blood cells from a 27-year-old woman, who was negative for HIV antibodies and p24 antigen at the time of donation, but seroconverted thereafter. Plasma viral load at donation was 2538 HIV RNA copies/ml. Phylogenetic analyses demonstrated that viruses from both patients clustered tightly together, belonged to subtype B clade, and had no primary drug resistance mutations. This case highlights the residual risk of HIV transmission from donors in the window period, and supports the implementation of nucleic acid testing in blood banks.
Toro
Carlos
C
Department of Infectious Diseases, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Rodés
Berta
B
Colino
Félix
F
del Valle Flores
Maria
M
Poveda
Eva
E
de Mendoza
Carmen
C
Téllez
Maria Jesús
MJ
Soriano
Vincent
V
D000328:Adult; D000368:Aged; D001782:Blood Donors; D001803:Blood Transfusion; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D016655:HIV Core Protein p24 / Q000097:blood; D015658:HIV Infections / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood*
D015483:HIV Antibodies; D016655:HIV Core Protein p24; D012367:RNA, Viral