title: Metal-enhanced emission from indocyanine green: a new approach to in vivo imaging.
abstract: Indocyanine green (ICG) is widely used in medical imaging and testing. Its complex spectral behavior and low quantum yield limits some applications. We show that proximity of ICG to a metallic silver particle increases its intensity approximately 20-fold and decreases the decay time. Since the rate of photobleaching is not increased, our results suggest that ICG-silver particle complexes can yield at least 20-fold more photons per ICG molecule for improved medical imaging.
authors.affiliation: University of Maryland School of Medicine, Department of Biochemistry & Molecular Biology, Center for Fluorescence Spectroscopy, 725 W. Lombard Street, Baltimore, Maryland 21201-1503, USA.
authors.forename: Joanna
authors.initials: J
authors.lastname: Malicka
authors.forename: Ignacy
authors.initials: I
authors.lastname: Gryczynski
authors.forename: Chris D
authors.initials: CD
authors.lastname: Geddes
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Lakowicz
mesh_terms: D003198:Computer Simulation; D005453:Fluorescence; D006801:Humans; D007208:Indocyanine Green / Q000737:chemistry*; D046911:Macromolecular Substances; D008670:Metals / Q000737:chemistry; D008956:Models, Chemical; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D046911:Macromolecular Substances; D008670:Metals; D012709:Serum Albumin; D012834:Silver; D007208:Indocyanine Green