First-trimester sex hormone binding globulin and subsequent gestational diabetes mellitus.
OBJECTIVE
We sought to examine the association between early pregnancy levels of sex hormone binding globulin and subsequent gestational diabetes mellitus, an association that has not been studied previously.


METHODS
We conducted a nested case-control study of 44 patients with gestational diabetes mellitus and 94 women with negative third-trimester screening for gestational diabetes mellitus. Sex hormone binding globulin levels were measured from serum samples that had been collected in the first trimester, and clinical data were ascertained from prospectively collected electronic medical records.


RESULTS
Compared with women without gestational diabetes mellitus, first-trimester sex hormone binding globulin levels were lower among women in whom gestational diabetes mellitus subsequently developed (187 +/- 82 nmol/L vs 233 +/- 92 nmol/L, P <.01). In logistic regression analysis that was adjusted for body mass index, age, race, smoking, blood pressure, serum testosterone and estradiol levels, and gestational age at serum collection, sex hormone binding globulin levels remained independently associated with subsequent gestational diabetes mellitus. For every 50-nmol/L increase in sex hormone binding globulin, the odds of gestational diabetes mellitus fell by 31% (odds ratio, 0.69; 95% CI: 0.48, 0.99).


CONCLUSIONS
Sex hormone binding globulin offers a potential early marker to target women who are at risk for gestational diabetes mellitus.
Thadhani
Ravi
R
Departments of Medicine and Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. thadhani.r@mgh.harvard.edu
Wolf
Myles
M
Hsu-Blatman
Karen
K
Sandler
Laura
L
Nathan
David
D
Ecker
Jeffrey L
JL
D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D004958:Estradiol / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D016015:Logistic Models; D016017:Odds Ratio; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012016:Reference Values; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013739:Testosterone / Q000097:blood
D001786:Blood Glucose; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol