Regulation of vascular development by fibroblast growth factors.
Fibroblast growth factors (FGFs) are potent stimulators of angiogenesis in vitro and in vivo. However, the precise role of FGFs and vascular development in normal and pathological tissue has long remained ill defined. Recently, substantial progress has been made toward a better understanding of their role. Genetic studies in mice or in culture systems indicate a role for FGFs in vessel assembly and sprouting. FGFs also stimulate blood vessel branching and lymphangiogenesis. The molecular mechanisms by which FGFs mediate angiogenesis are also better understood. Finally, the FGF/FGF-receptor system has become a focus for the development of novel therapeutic strategies for the treatment of angiogenesis-related diseases such as tissue ischemia.
Auguste
Patrick
P
Molecular Angiogenesis Laboratory (INSERM EMI 0113), University Bordeaux I, Avenue des Facultés, 33405, Talence, France.
Javerzat
Sophie
S
Bikfalvi
Andreas
A
D000818:Animals; D001808:Blood Vessels / Q000254:growth & development*; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006801:Humans; D007511:Ischemia / Q000503:physiopathology; D008208:Lymphatic System / Q000254:growth & development; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism; D015398:Signal Transduction
D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors