[The study of the role of the water medium in the mechanism of action of peptides in low and ultra low doses].
The correlation between the structures and conformations of short peptides KE, EW, AEDG and other, their influence on the dynamic properties of water and dose/biologic effect dependencies in a wide range of concentrations were regarded. Their effects on the dynamic properties of water were studied by temperature dependencies (5-45 degrees C) of infrared spectra of the solutions in the near (5180 cm-1) and far (200 cm-1). In vitro biotesting included the determination of the proliferative activity of thymocytes, a bimodal curve with the second maximum were detected at super-low doses (10(-17)-10(-15) mol/l). Authors propose a hypothesis that for superlow concentrations the formation and distance transmission of a signal from ligand to a target cell without the formation of any ligand-receptor complex take place. An active role in this model belongs to water medium acting according to the solution mechanism.
Grigor'ev
E I
EI
St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, 197110 Russia. ibg@medport.ru
Khavinson
V Kh
VKh
Malinin
V V
VV
Grigor'ev
A E
AE
Kochnev
I N
IN
Kudriavtseva
T A
TA
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D003470:Culture Media; D004151:Dipeptides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008958:Models, Molecular; D008962:Models, Theoretical; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D011487:Protein Conformation; D012996:Solutions; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D014867:Water / Q000737:chemistry / Q000378:metabolism
D003470:Culture Media; D004151:Dipeptides; D009842:Oligopeptides; D010455:Peptides; D012996:Solutions; D014867:Water; D003208:Concanavalin A; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine