Choleretic actions of insulin-like growth factor-I, prednisolone, and ursodeoxycholic acid in rats.
A recent study by our group demonstrated that a 1-week infusion of insulin-like growth factor-I increases bile flow volume and bile acid secretion in rats, suggesting it is important in in vivo choleresis. In the present study, the effect in rats of a single administration of insulin-like growth factor-I on bile flow volume was investigated and compared with the choleretic drugs prednisolone and ursodeoxycholic acid. A significant and long-lasting increase in bile flow volume was observed in rats treated with insulin-like growth factor-I or prednisolone. Ursodeoxycholic acid significantly, but transiently increased. Combined treatment using insulin-like growth factor-I with prednisolone or ursodeoxycholic acid additively increased bile flow volume. Overall, this study demonstrated that the stimulatory effect of insulin-like growth factor-I on bile flow volume is almost equally potent to that of prednisolone and ursodeoxycholic acid, indicating the possible therapeutic potential of insulin-like growth factor-I in cholestatic liver diseases.
Mabuchi
Miyuki
M
Department of Metabolic Diseases, Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 2-1-6, Kashima, Yodogawa-ku, Osaka 532-8514, Japan.
Kawamura
Ikuo
I
Fushimi
Mariko
M
Takeshita
Shigeru
S
Takakura
Shoji
S
Hirosumi
Jiro
J
Mutoh
Seitaro
S
D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000502:physiology; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D004068:Digestive System Physiological Phenomena / Q000187:drug effects*; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D008297:Male; D011239:Prednisolone / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014580:Ursodeoxycholic Acid / Q000494:pharmacology*
D002756:Cholagogues and Choleretics; D007334:Insulin-Like Growth Factor I; D014580:Ursodeoxycholic Acid; D011239:Prednisolone