title: Hypereosinophilia with abnormal T cells, trisomy 7 and elevated TARC serum level.
abstract: The idiopathic hypereosinophilic syndrome (HES) is a rare heterogeneous disorder, characterized by persistent blood eosinophilia with possible organ involvement. We describe here the case of a 20-year-old atopic male presenting chronic hypereosinophilia and eczema since childhood. Biological findings included hypereosinophilia (9.5 x 10(9)/L), hyperlymphocytosis (10.9 x 10(9)/L), polyclonal hypergammaglobulinemia and elevated IgE serum level. Flow cytometric analysis of blood lymphoid cells showed a population of CD2+CD3-CD4+TCRab-TCRgd- lymphocytes. These cells displayed a Th0/Th2 cytokine profile, and a clonal TCR rearrangement pattern. A high serum TARC level was observed. Karyotype studies on blood stimulated culture or lymph nodes revealed a cellular hyperdiploïd clone 47, XY, +7. To our knowledge, this chromosomal aberration has never been reported in such case.
authors.affiliation: INSERM U547, Institut Pasteur, 1 rue du Professeur Calmette, BP 245, 59019 LILLE Cedex, FRANCE. asroumier@yahoo.fr
authors.forename: A S
authors.initials: AS
authors.lastname: Roumier
authors.forename: N
authors.initials: N
authors.lastname: Grardel
authors.forename: J L
authors.initials: JL
authors.lastname: Laï
authors.forename: I
authors.initials: I
authors.lastname: Becqueriaux
authors.forename: K
authors.initials: K
authors.lastname: Ghomari
authors.forename: A
authors.initials: A
authors.lastname: de Lavareille
authors.forename: F
authors.initials: F
authors.lastname: Roufosse
authors.forename: L
authors.initials: L
authors.lastname: Prin
authors.forename: M
authors.initials: M
authors.lastname: Capron
mesh_terms: D000328:Adult; D054414:Chemokine CCL17; D019742:Chemokines, CC / Q000097:blood*; D002897:Chromosomes, Human, Pair 7; D002999:Clone Cells; D016207:Cytokines / Q000032:analysis / Q000097:blood; D015329:Gene Rearrangement, T-Lymphocyte; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis* / Q000276:immunology*; D016130:Immunophenotyping; D015848:Interleukin-5 / Q000096:biosynthesis; D007621:Karyotyping; D008214:Lymphocytes / Q000145:classification; D008218:Lymphocytosis / Q000175:diagnosis; D008297:Male; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D014314:Trisomy
chemical_list: C106230:CCL17 protein, human; D054414:Chemokine CCL17; D019742:Chemokines, CC; D016207:Cytokines; D015848:Interleukin-5; D016178:Granulocyte-Macrophage Colony-Stimulating Factor