A facile solid phase synthesis of tetramic acid.
The condensation of N-acylated amino acids with polymer-supported cyclic malonic acid ester was carried out in the presence of DCC/DMAP. The cyclisation of the intermediate resin, by heating in an organic solvent, gave the N-protected tetramic acid derivatives in good yields and high purity.
Liu
Zhanxiang
Z
Department of Chemistry, Zhejiang University, Campus Xixi, Hangzhou, 310028, People's Republic of China.
Ruan
Xiuxiu
X
Huang
Xian
X
D000215:Acylation; D000596:Amino Acids / Q000138:chemical synthesis; D007202:Indicators and Reagents; D008314:Malonates / Q000737:chemistry; D011760:Pyrrolidinones / Q000138:chemical synthesis*; D012997:Solvents; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
D000596:Amino Acids; D007202:Indicators and Reagents; D008314:Malonates; D011760:Pyrrolidinones; D012997:Solvents; C009435:tetramic acid; C030290:malonic acid