Radiolabelled lymphokines and growth factors for in vivo imaging of inflammation, infection and cancer.
Radiolabelled cytokines and chemokines are a new group of radiopharmaceuticals. These, by binding to specific receptors expressed on selected cell populations, enable the histological and functional characterization of immune-mediated processes, in vivo. Clinical studies have demonstrated the efficacy of using this type of scintigraphy in detecting sites of acute inflammation (infection) and chronic (T-cell-mediated) inflammation. Recent studies are focusing on the possible use of radiolabelled cytokines and chemokines for the biological characterization of cancer cells in vivo. In particular, the homing of metastases into specific tissues could depend on the chemoattraction of these tissues, mediated by soluble chemokines that bind to specific receptors expressed on cancer cells. These studies will generate a deeper knowledge of the molecular mechanism of tumor metastasis and lead to new therapies in nuclear medicine.
Signore
Alberto
A
Nuclear Medicine Unit, Department of Clinical Sciences, University La Sapienza, Via del Policlinico 155, 00161, Roma, Italy. alberto.signore@uniroma1.it <alberto.signore@uniroma1.it>
Capriotti
Gabriela
G
Scopinaro
Francesco
F
Bonanno
Elena
E
Modesti
Andrea
A
D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology; D018925:Chemokines; D016207:Cytokines; D005260:Female; D006133:Growth Substances; D006801:Humans; D007239:Infections / Q000000981:diagnostic imaging* / Q000276:immunology; D007249:Inflammation / Q000000981:diagnostic imaging* / Q000276:immunology; D008222:Lymphokines; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals
D018925:Chemokines; D016207:Cytokines; D006133:Growth Substances; D008222:Lymphokines; D019275:Radiopharmaceuticals