title: The design and synthesis of guanosine compounds with in vitro activity against the colon cancer cell line SW480: non-taxane derived mimics of taxol?
abstract: In the course of our investigation into the use of taxol as a lead compound to design new molecules with anti-cancer activity, we have synthesized four compounds based on protected guanosine coupled to taxol isoserine side-chain analogues. These analogues show in vitro anti-cancer activity against the colon cancer cell line SW480 that their constituent parts do not.
authors.affiliation: School of Chemical Sciences, Dublin City University, Dublin 9, Ireland. joshua.howarth@dcu.ie
authors.forename: Joshua
authors.initials: J
authors.lastname: Howarth
authors.forename: Padraic
authors.initials: P
authors.lastname: Kenny
authors.forename: Susan
authors.initials: S
authors.lastname: McDonnell
authors.forename: Aine
authors.initials: A
authors.lastname: O'Connor
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D001952:Bridged-Ring Compounds; D045744:Cell Line, Tumor / Q000187:drug effects; D003110:Colonic Neoplasms; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006151:Guanosine / Q000031:analogs & derivatives*; D006801:Humans; D008870:Microtubules / Q000187:drug effects; D017239:Paclitaxel / Q000031:analogs & derivatives*; D013329:Structure-Activity Relationship; D043823:Taxoids
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001952:Bridged-Ring Compounds; D043823:Taxoids; D006151:Guanosine; C080625:taxane; D017239:Paclitaxel