title: Evolutionary algorithms for the selection of single nucleotide polymorphisms.
abstract: BACKGROUND
  Large databases of single nucleotide polymorphisms (SNPs) are available for use in genomics studies. Typically, investigators must choose a subset of SNPs from these databases to employ in their studies. The choice of subset is influenced by many factors, including estimated or known reliability of the SNP, biochemical factors, intellectual property, cost, and effectiveness of the subset for mapping genes or identifying disease loci. We present an evolutionary algorithm for multiobjective SNP selection.
  
  
  RESULTS
  We implemented a modified version of the Strength-Pareto Evolutionary Algorithm (SPEA2) in Java. Our implementation, Multiobjective Analyzer for Genetic Marker Acquisition (MAGMA), approximates the set of optimal trade-off solutions for large problems in minutes. This set is very useful for the design of large studies, including those oriented towards disease identification, genetic mapping, population studies, and haplotype-block elucidation.
  
  
  CONCLUSIONS
  Evolutionary algorithms are particularly suited for optimization problems that involve multiple objectives and a complex search space on which exact methods such as exhaustive enumeration cannot be applied. They provide flexibility with respect to the problem formulation if a problem description evolves or changes. Results are produced as a trade-off front, allowing the user to make informed decisions when prioritizing factors. MAGMA is open source and available at http://snp-magma.sourceforge.net. Evolutionary algorithms are well suited for many other applications in genomics.
authors.affiliation: Institute for Systems Biology, Seattle, WA, USA. rhubley@systemsbiology.org
authors.forename: Robert M
authors.initials: RM
authors.lastname: Hubley
authors.forename: Eckart
authors.initials: E
authors.lastname: Zitzler
authors.forename: Jared C
authors.initials: JC
authors.lastname: Roach
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D019143:Evolution, Molecular; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011381:Programming Languages; D012641:Selection, Genetic; D012984:Software
chemical_list: D005819:Genetic Markers