title: Majority of interferon-gamma-producing CD4+ cells in patients infected with human T cell lymphotrophic virus do not express tax protein.
abstract: The present study was conducted to determine whether interferon (IFN)-gamma production by CD4(+) cells in patients infected with human T cell lymphotropic virus (HTLV) is associated with expression of Tax, an HTLV type 1 (HTLV-1) transactivator. The frequency of IFN-gamma production from CD4(+) cells was greater in HTLV-1-infected patients (n=21) than in uninfected (n=3) and Strongyloides stercoralis-infected patients (n=4), and greater in patients with HTLV-1 with detectable Tax than in patients with HTLV-1 with undetectable Tax. In the patients with HTLV-1 with detectable Tax, the majority of CD4(+) cells making IFN-gamma did not express Tax.
authors.affiliation: Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Edward
authors.initials: E
authors.lastname: Mitre
authors.forename: Robert W
authors.initials: RW
authors.lastname: Thompson
authors.forename: Edgar M
authors.initials: EM
authors.lastname: Carvalho
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Nutman
authors.forename: Franklin A
authors.initials: FA
authors.lastname: Neva
mesh_terms: D001782:Blood Donors; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000821:virology; D002478:Cells, Cultured; D016356:Gene Products, tax / Q000378:metabolism*; D015490:HTLV-I Infections / Q000097:blood / Q000276:immunology*; D015368:Human T-lymphotropic virus 1 / Q000378:metabolism*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D016399:Lymphoma, T-Cell / Q000276:immunology*
chemical_list: D016356:Gene Products, tax; D007371:Interferon-gamma