title: Olmsted syndrome: the clinical spectrum of mutilating palmoplantar keratoderma.
abstract: Olmsted syndrome is a rare variety of transgredient palmoplantar keratoderma with an undefined inheritance pattern. It starts in the neonatal period or in childhood and has a progressive and extremely disabling course. We report two new, unrelated patients with Olmsted syndrome, one with the early signs and symptoms of the disorder, the other showing the full-blown spectrum of the syndrome during a 30-year follow-up period.
authors.affiliation: Hospital das Clínicas, University of São Paulo, São Paulo, Brazil.
authors.forename: Fabiane N
authors.initials: FN
authors.lastname: Bergonse
authors.forename: Suzy M
authors.initials: SM
authors.lastname: Rabello
authors.forename: Rodrigo L
authors.initials: RL
authors.lastname: Barreto
authors.forename: Ricardo
authors.initials: R
authors.lastname: Romiti
authors.forename: Marcello Menta S
authors.initials: MM
authors.lastname: Nico
authors.forename: Valéria
authors.initials: V
authors.lastname: Aoki
authors.forename: Vitor Manoel S
authors.initials: VM
authors.lastname: Reis
authors.forename: Evandro A
authors.initials: EA
authors.lastname: Rivitti
mesh_terms: D000671:Amputation, Surgical; D002675:Child, Preschool; D018450:Disease Progression; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D013577:Syndrome