Successful medical treatment of Candida albicans in mechanical prosthetic valve endocarditis.
Fungal prosthetic valve endocarditis is particularly serious, and is usually a result of nosocomial candidaemia. This report describes a patient with Candida albicans prosthetic valve endocarditis in whom surgery was believed to be contraindicated. After 45 d of amphotericin B, treatment was continued with fluconazole daily with a follow-up of 16 months, with no recurrent or adverse effects.
Aaron
Laurent
L
Service des maladies infectieuses et tropicales, Hôpital Necker Enfants-Malades, Paris, France. LAAARON@wanadoo.fr
Therby
Audrey
A
Viard
Jean-Paul
JP
Lahoulou
Rima
R
Dupont
Bertrand
B
D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage*; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification*; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004696:Endocarditis / Q000175:diagnosis / Q000188:drug therapy*; D015725:Fluconazole / Q000008:administration & dosage; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D008297:Male; D011379:Prognosis; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000188:drug therapy*; D018570:Risk Assessment; D016896:Treatment Outcome
D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole