title: Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors.
abstract: The melanotropin peptides alpha-MSH, gamma-MSH, and beta-MSH are believed to be the natural ligands for the four melanocortin receptors, MC1R, MC3R, MC4R, and MC5R. However, these peptides generally have low selectivity for these receptors. We report on some approaches to the development of selective agonists and antagonists peptide ligands for these receptors.
authors.affiliation: Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA. hruby@u.arizona.edu
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Hruby
authors.forename: Minying
authors.initials: M
authors.lastname: Cai
authors.forename: Paolo
authors.initials: P
authors.lastname: Grieco
authors.forename: Guoxia
authors.initials: G
authors.lastname: Han
authors.forename: Malcolm
authors.initials: M
authors.lastname: Kavarana
authors.forename: Dev
authors.initials: D
authors.lastname: Trivedi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015195:Drug Design; D006801:Humans; D008024:Ligands; D009074:Melanocyte-Stimulating Hormones / Q000737:chemistry* / Q000378:metabolism; D018043:Receptors, Corticotropin / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D044101:Receptors, Melanocortin; D013379:Substrate Specificity
chemical_list: D008024:Ligands; D018043:Receptors, Corticotropin; D044101:Receptors, Melanocortin; D009074:Melanocyte-Stimulating Hormones