Dietary CLA affects lipid metabolism in broiler chicks.
A total of 120 three-wk-old broiler chicks were randomly assigned to three diets containing 0, 2, or 3% CLA and fed for 5 wk. Fat content and FA composition of liver, plasma, and feces were analyzed. Key enzymes involved in FA synthesis and catabolism in liver, TG, cholesterol, and FFA content of plasma were also determined. Dietary CLA increased TG, total cholesterol, and HDL cholesterol levels in plasma. The increased plasma TG level could be caused by increased FA synthesis in the liver after CLA feeding, because the activity of FA synthase in the liver increased after dietary CLA treatment. Dietary CLA changed the FA composition of feces but had no effect on fat content. Compared to the amounts of linoleic and linolenic acids present in the control diet, the amounts excreted into the feces of CLA-treated birds were significantly higher. Liver weights of broilers significantly increased after CLA feeding, but there was no difference in liver fat content among the different CLA treatments. CLA treatment did not influence total FFA content in plasma; however, there was a significant difference in the composition of FFA. Dietary CLA reduced the content of linoleic and arachidonic acids in both plasma and liver.
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Department of Animal Science, Iowa State University, Ames, Iowa 50011-3150, USA.
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D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000818:Animals; D002334:Carnitine O-Palmitoyltransferase / Q000378:metabolism; D002645:Chickens; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D064429:Fatty Acid Synthases / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D044243:Linoleic Acids, Conjugated / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000254:growth & development; D009929:Organ Size / Q000187:drug effects; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D004041:Dietary Fats; D005227:Fatty Acids; D044243:Linoleic Acids, Conjugated; D014280:Triglycerides; D002784:Cholesterol; D002334:Carnitine O-Palmitoyltransferase; D064429:Fatty Acid Synthases; D000103:Acetyl-CoA Carboxylase