Expression and function of tumour necrosis factor-alpha-converting enzyme in the central nervous system.
Tumour necrosis factor-alpha (TNF-alpha)-converting enzyme (TACE/ADAM17) is a membrane protein belonging to the ADAM (a disintegrin and a metalloprotease) family able to cleave various membrane proteins, including the transmembrane form of TNF-alpha at its physiological processing site. Being an ADAM, TACE may mediate not only proteolysis but also adhesive interactions; however, the role of the disintegrin domain of TACE has not been studied. In the central nervous system (CNS), little is known about the physiological role of TACE, but some important pathophysiological functions have been reported recently, with both neurotoxic and neuroprotective repercussions. This article discusses and reviews the main contributions to this field of investigation addressing the expression and function of TACE in the CNS.
Moro
Maria A
MA
Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain. neurona@med.ucm.es
Hurtado
Olivia
O
Cárdenas
Antonio
A
Romera
Cristina
C
Madrigal
Jose L M
JL
Fernández-Tomé
Paz
P
Leza
Juan C
JC
Lorenzo
Pedro
P
Lizasoain
Ignacio
I
D051722:ADAM Proteins; D000072198:ADAM17 Protein; D000818:Animals; D001921:Brain / Q000201:enzymology*; D008666:Metalloendopeptidases / Q000235:genetics / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha; D051722:ADAM Proteins; D008666:Metalloendopeptidases; D000072198:ADAM17 Protein