[3H]RX 821002 in human dorsolateral prefrontal cortex: no changes in postmortem tissue from subjects with schizophrenia.
One of the major differences between the atypical antipsychotic drugs clozapine and olanzapine is that clozapine has a two-fold higher affinity for the alpha(2)-adrenoreceptors. As clozapine can have therapeutic benefits in individuals that do not respond to other antipsychotic drugs, this raises the possibility that changes in the alpha(2)-adrenoreceptors could be a marker for a predisposition to treatment resistance. A methodology has been optimised to measure the binding of [3H]RX 821002 to alpha(2)-adrenoreceptors in human postmortem CNS and has shown that these receptors are not altered in Brodmann's area 9 from subjects with schizophrenia. These data add to those of one other study that showed the alpha(2)-adrenoreceptors were not altered in Brodmann's area 10 and the hippocampus from subjects with schizophrenia, and do not support the hypothesis that changes in alpha(2)-adrenoreceptors are a marker for treatment resistance in schizophrenia.
Dean
Brian
B
Rebecca L. Cooper Research Laboratories, Mental Health Research Institute of Victoria, Victoria, Parkville, Australia. bdean@mhri.edu.au
D058669:Adrenergic alpha-2 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000493:pharmacokinetics*; D000328:Adult; D000368:Aged; D001569:Benzodiazepines / Q000627:therapeutic use; D001665:Binding Sites; D003024:Clozapine / Q000627:therapeutic use; D005260:Female; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D019329:Idazoxan / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D011180:Postmortem Changes; D017397:Prefrontal Cortex / Q000378:metabolism* / Q000473:pathology*; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D012702:Serotonin Antagonists / Q000627:therapeutic use
D058669:Adrenergic alpha-2 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D012702:Serotonin Antagonists; D001569:Benzodiazepines; C058525:2-methoxyidazoxan; D003024:Clozapine; D000077152:Olanzapine; D019329:Idazoxan