title: CD4+ T cell polarization in mice is modulated by strain-specific major histocompatibility complex-independent differences within dendritic cells.
abstract: Resistance and susceptibility to Leishmania major in mice are determined by multiple genes and correlate with the preferential development of Th1 and Th2 responses, respectively. Here, we found that CD11b+ dendritic cells (DCs) prime parasite-specific CD4+ T cells in both susceptible BALB/c (H2-d) and resistant B10.D2 (H2-d) mice. However, BALB/c and B10.D2 DCs from L. major-infected mice differ in their ability to polarize naive T cells into Th1 or Th2 effector cells. This difference is cell-intrinsic, is not restricted to H2-d mice, and is observed with both parasite-specific and allospecific CD4+ T cells. Thus, strain-specific differences within CD11b+ DCs influence the ability of inbred mice to mount polarized CD4+ T cell responses.
authors.affiliation: E03-44, Institut National de la Santé et de la Recherche Médicale, University of Nice-Sophia Antipolis, 660 Route des Lucioles, 06560 Valbonne, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Filippi
authors.forename: Stephanie
authors.initials: S
authors.lastname: Hugues
authors.forename: Julie
authors.initials: J
authors.lastname: Cazareth
authors.forename: Valerie
authors.initials: V
authors.lastname: Julia
authors.forename: Nicolas
authors.initials: N
authors.lastname: Glaichenhaus
authors.forename: Sophie
authors.initials: S
authors.lastname: Ugolini
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016764:Cell Polarity; D016207:Cytokines / Q000235:genetics; D003713:Dendritic Cells / Q000276:immunology*; D004198:Disease Susceptibility; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007113:Immunity, Innate; D016773:Leishmaniasis, Cutaneous / Q000235:genetics / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D012333:RNA, Messenger / Q000235:genetics; D013045:Species Specificity; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D016207:Cytokines; D000949:Histocompatibility Antigens Class II; D012333:RNA, Messenger