title: Diabetes and vascular disease: a new international trial.
abstract: The prevalence of diabetes is increasing, particularly in developing regions of the world. The social and economic consequences of this disease and its complications are enormous. We discuss the scope and implications of the increasing burden of diabetes and describe the rationale and design of a new international study examining blood pressure lowering and glucose control interventions aimed at reducing the risk of vascular complications in people with type 2 diabetes. This study is the first large-scale randomized trial in diabetes to include participants from both lower- and higher-income regions of the world.
authors.affiliation: International Coordinating Centre for ADVANCE, Institute for International Health, University of Sydney, PO Box 576, Newtown, New South Wales 2042, Australia. apatel@iih.usyd.edu.au
authors.forename: Anushka
authors.initials: A
authors.lastname: Patel
authors.forename: John
authors.initials: J
authors.lastname: Chalmers
authors.forename: Vivek
authors.initials: V
authors.lastname: Chaturvedi
authors.forename: Rochelle
authors.initials: R
authors.lastname: Currie
authors.forename: Helen
authors.initials: H
authors.lastname: Monaghan
authors.forename: Bruce
authors.initials: B
authors.lastname: Neal
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D003906:Developing Countries; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000453:epidemiology; D003925:Diabetic Angiopathies / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D005907:Gliclazide / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007391:International Cooperation; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents; D007004:Hypoglycemic Agents; D005907:Gliclazide