title: Effects of benidipine hydrochloride on autonomic nervous activity in hypertensive patients with high- and low-salt diets.
abstract: The effects of benidipine hydrochloride (CAS 91559-74-5, Coniel) on autonomic nervous activity in hypertensive patients with high- and low-salt diets were investigated. Six patients having a urinary sodium excretion of 80 mEq/day or less (low salt group) and 6 patients having a urinary sodium excretion of 200 mEq/day or more (high salt group) were orally given benidipine hydrochloride (4 mg). Before and four weeks after the treatment with benidipine, 24-h circadian variation in blood pressure and 24-h Holter electrocardiogram (ECG) were recorded. The low frequency power spectrum of heart rate (LF power; 0.04-0.15 Hz), high frequency power spectrum of heart rate (HF power; 0.15-0.40 Hz), and the ratio of LF to HF (LF/HF) were calculated, and these parameters were averaged every hour in every subject. HF power was significantly lower and LF/HF ratio was significantly higher in the high-salt group than in the low-salt group before the treatment. However, the benidipine treatment significantly increased the HF power in both groups, particularly in the high-salt group, and significantly decreased the LF/HF ratio in both groups. Moreover, there was no significant difference in the antihypertensive effect of benidipine between the high- and low-salt intake groups. These results suggest that benidipine favourably influences blood pressure and autonomic nervous activity in hypertensive patients with a high-salt intake. It is concluded that benidipine may be useful for improving the development of salt-induced hypertension and its accompanying haemodynamic responses.
authors.affiliation: Department of Digestion and Cardiovascular Medicine, School of Medicine, University of Tokushima, Tokushima, Japan. nomura@clin.med.tokushima-u.ac.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nomura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nakaya
authors.forename: Eiko
authors.initials: E
authors.lastname: Uemura
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Iga
authors.forename: Norihito
authors.initials: N
authors.lastname: Kageyama
authors.forename: Toru
authors.initials: T
authors.lastname: Nakayama
authors.forename: Kanji
authors.initials: K
authors.lastname: Kusunoki
authors.forename: Tomohito
authors.initials: T
authors.lastname: Kawano
authors.forename: Kansei
authors.initials: K
authors.lastname: Katoh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okamoto
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Nishikado
authors.forename: Ken
authors.initials: K
authors.lastname: Saito
authors.forename: Susumu
authors.initials: S
authors.lastname: Ito
mesh_terms: D000368:Aged; D001341:Autonomic Nervous System / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D004039:Diet, Sodium-Restricted; D004095:Dihydropyridines / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012982:Sodium, Dietary / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D012982:Sodium, Dietary; C061004:benidipine