Hypocholesterolemic activity of hesperetin derivatives.
Hesperetin ester and ether derivatives possessing a long alkyl chain were synthesized for examining their hypocholesterolemic activities in high cholesterol-fed mice. Hesperetin 7-O-lauryl ether (4b) and hesperetin 7-O-oleyl ether (4e) exhibited strong cholesterol-lowering effects.
Jeong
Tae-Sook
TS
Korea Research Institute of Bioscience and Biotechnology, 52 Oun, Yusong, Taejon 305-333, Republic of Korea.
Kim
Eun Eai
EE
Lee
Chul-Ho
CH
Oh
Jung-Hoon
JH
Moon
Surk-Sik
SS
Lee
Woo Song
WS
Oh
Goo-Taeg
GT
Lee
Sangku
S
Bok
Song-Hae
SH
D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004987:Ethers / Q000138:chemical synthesis / Q000494:pharmacology; D006569:Hesperidin / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy; D051379:Mice; D013329:Structure-Activity Relationship; D013997:Time Factors
D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D004987:Ethers; C484475:hesperetin 7-O-lauryl ether; C484476:hesperetin 7-O-oleyl ether; D002784:Cholesterol; D006569:Hesperidin; C013015:hesperetin