NO activates the olfactory cyclic nucleotide-gated conductance independent from cGMP in isolated rat olfactory receptor neurons.
Nitric oxide (NO) is a putative neuronal messenger in the olfactory epithelium. We analysed the electrical responses of rat olfactory receptor neurones to NO stimulation in the whole-cell patch clamp mode and found that NO activates the cyclic nucleotide-gated conductance, independent from cyclic GMP. As NO may also open calcium-dependent potassium channels and raise cyclic GMP levels, it appears to act as a complex modulator of olfactory receptor neuron physiology in vivo.
Schmachtenberg
Oliver
O
Centro de Neurociencias de Valparaiso (CNV), Facultad de Ciencias, Universidad de Valparaiso, Avda. Gran Bretania 1111, Valparaíso, Chile. oliver@cnv.cl
Diaz
Javier
J
Bacigalupo
Juan
J
D000818:Animals; D006152:Cyclic GMP / Q000378:metabolism*; D054815:Cyclic Nucleotide-Gated Cation Channels; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism / Q000494:pharmacology*; D018034:Olfactory Receptor Neurons / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar
D054815:Cyclic Nucleotide-Gated Cation Channels; D007473:Ion Channels; D009569:Nitric Oxide; D006152:Cyclic GMP