[Mucocutaneous bullous pemphigoid induced by valsartan. A clinical case].
In the presence of immune-mediated vesiculo-bullous diseases, the oral pathologist should focus his attention not only on the diagnosis and treatment of the case, but should particularly investigate the state of genetic predisposition in relation to the HLA haplotype structure and look for the possible trigger factors for the disease. The detection of the trigger may guarantee a faster cure with a minimum therapeutic contribution. In the search for triggering factors, the drugs that are traditionally incriminated such as ACE inhibitors, Fans, antibiotics (penicillin and penicillamine), substances with -SH groups, tranquillisers, are not always involved in inducing vesiculo-bullous diseases. Substances considered innocuous are often to blame. We present a case of mucous-cutaneous bullous pemphigoid induced by an anti-hypertensive of the sartan group, valsartan.
Femiano
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Reparto di Patologia Orale, Prima Clinica Odontostomatologica, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Napoli, Italy. femiano@libero.it
D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D008297:Male; D010390:Pemphigoid, Benign Mucous Membrane / Q000139:chemically induced*; D010391:Pemphigoid, Bullous / Q000139:chemically induced*; D013777:Tetrazoles / Q000009:adverse effects*; D014633:Valine / Q000009:adverse effects* / Q000031:analogs & derivatives; D000068756:Valsartan
D000959:Antihypertensive Agents; D013777:Tetrazoles; D000068756:Valsartan; D014633:Valine