Acute psychosis associated with levetiracetam.
A twelve year-old-girl with idiopathic partial epilepsy with secondary generalization, developed acute psychosis 10 days after the administration of levetiracetam. The patient was already on sodium valproate, and levetiracetam was given as add on therapy. A final dosage of 60 mg/kg was used. Complete seizure control was achieved but the patient developed hallucinations, agitation and self-harming behaviour, as well as poor social contact. The psychotic behavior resolved completely soon after the discontinuation of levetiracetam.
Youroukos
Sotiris
S
First Department of Paediatrics, Athens University Medical School, "St. Sophia" Children's Hospital, Athens, Greece. sotel@hol.gr
Lazopoulou
Despina
D
Michelakou
Danae
D
Karagianni
Joanna
J
D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004828:Epilepsies, Partial / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D010889:Piracetam / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011605:Psychoses, Substance-Induced / Q000175:diagnosis / Q000209:etiology*; D014635:Valproic Acid / Q000009:adverse effects / Q000627:therapeutic use
D000927:Anticonvulsants; D000077287:Levetiracetam; D014635:Valproic Acid; D010889:Piracetam