title: Low frequency of the V106M mutation among HIV-1 subtype C-infected pregnant women exposed to nevirapine.
abstract: Nevirapine used in single doses to prevent mother-to-child transmission has been shown to be associated with the development of transient resistant mutations. Here we describe the presence of V106M in seven out of 141 South African women (5%) 6 weeks after receiving nevirapine. V106M is a novel resistance mutation found in subtype C viruses exposed to efavirenz. This mutation is thus also induced at a low frequency in subtype C viruses exposed to single dose nevirapine.
authors.affiliation: AIDS Virus Research Unit, National Institute for Communicable Diseases, Sandringham, Johannesburg, South Africa.
authors.forename: Lynn
authors.initials: L
authors.lastname: Morris
authors.forename: Candice
authors.initials: C
authors.lastname: Pillay
authors.forename: Claudia
authors.initials: C
authors.lastname: Chezzi
authors.forename: Pumla
authors.initials: P
authors.lastname: Lupondwana
authors.forename: Matshediso
authors.initials: M
authors.lastname: Ntsala
authors.forename: Leon
authors.initials: L
authors.lastname: Levin
authors.forename: Francois
authors.initials: F
authors.lastname: Venter
authors.forename: Neil
authors.initials: N
authors.lastname: Martinson
authors.forename: Glenda
authors.initials: G
authors.lastname: Gray
authors.forename: James
authors.initials: J
authors.lastname: McIntyre
mesh_terms: D000328:Adult; D003906:Developing Countries; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D019829:Nevirapine / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000821:virology*; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D013019:South Africa
chemical_list: D018894:Reverse Transcriptase Inhibitors; D019829:Nevirapine