Effects of whisky on plasma gastrin and cholecystokinin in young adult men.
Whisky (1 g/kg, 21.5% alcohol) was administered orally to healthy young adult male volunteers, and changes in the plasma concentrations of alcohol, acetaldehyde, gastrin, cholecystokinin (CCK) and serum amylase were measured over time. Values for alcohol and acetaldehyde rapidly reached a peak at 30-45 min after alcohol intake, followed by a gradual decline. The plasma gastrin concentration showed a rapid elevation, while the plasma CCK concentration did not exhibit any significant changes in the early phase after alcohol intake. Elevation of CCK was observed after 75 min, however. These results show that intake of whisky stimulates the secretion of gastrin and is associated with a later increase in CCK.
Manabe
T
T
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuhoku, Nagoya, Japan. mnb@med.nagoya-cu.ac.jp
Sawai
H
H
Okada
Y
Y
Funahashi
H
H
Yamamoto
M
M
Sato
M
M
Hayakawa
T
T
Yamaki
K
K
D000079:Acetaldehyde / Q000097:blood; D000328:Adult; D002492:Central Nervous System Depressants / Q000008:administration & dosage* / Q000097:blood; D002766:Cholecystokinin / Q000097:blood*; D000431:Ethanol / Q000008:administration & dosage* / Q000097:blood; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male
D002492:Central Nervous System Depressants; D005755:Gastrins; D000431:Ethanol; D002766:Cholecystokinin; D000079:Acetaldehyde