[Antidepressant effect of ethanol extracts from three species of sect. Hypericum medicinal plants in mice].
OBJECTIVE
To explore the antidepressant actions of ethanol extracts from three species of sect. Hypericum medicinal plants.


METHODS
The forced swimming test and mouse tail suspensions in mice were used.


RESULTS
Ethanol extracts of sect. Hypericum medicinal plants significantly shortened motionless time of mice forced swimming and despair time of mouse tail suspension in the two behavior despair animal models of depression. The effect of H. faberi was weaker than that of H. perforatum.


CONCLUSIONS
These findings demonstrated that the extracts from three species of sect. Hypericum medicinal plants possessed obvious antidepressant activity.
Wan
Deguan
D
Chengdu University of Traditional Chinese Medicine, 610075.
Pei
Jin
J
Zhou
Mingmei
M
Wang
Guangzhi
G
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D020902:Hypericum / Q000737:chemistry* / Q000145:classification; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D011597:Psychomotor Performance / Q000187:drug effects; D013045:Species Specificity; D013550:Swimming
D000928:Antidepressive Agents; D004365:Drugs, Chinese Herbal