[A new coating method for cemented femur shaft implants--biocompatibility, stability during sterlization and adhesive strength].
The main cause of aseptic loosening of cemented stems in total hip arthroplasty is the hydrolytic degradation of the metal-cement interface. In order to prevent this debonding a new multilayer method of coating the implant surface involving the use of a silica-/silane technique to create a durable adhesive bond between metal stem and bone cement has been developed. The biocompatibility of all the elements of the multilayer system was confirmed using a human osteoblast cell culture test. For sterilization purposes, gamma irradiation with a 25 kGy effective dose proved to be the method of choice. The proven biocompatibility and successful sterilization of the coated implants are the main prerequisites for in-vivo usage. On the technical side, the bonding effectiveness of the multilayer coating system was demonstrated by the tensile test, which revealed a significant improvement in the adhesive strength of the cement-metal bond under prolonged moist conditions similar to those met with in the human body.
Wirtz
D Ch
DCh
Orthopädische Universitätsklinik, RWTH Aachen. DCWirtz@ukaachen.de
Fischer
H
H
Neuss
M
M
Ammenwerth
J
J
Niethard
F U
FU
Marx
R
R
D001843:Bone Cements; D002448:Cell Adhesion / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible; D019544:Equipment Failure Analysis; D006622:Hip Prosthesis; D006801:Humans; D008422:Materials Testing; D020366:Methylmethacrylate; D016348:Osseointegration / Q000502:physiology; D010006:Osteoblasts / Q000166:cytology; D012821:Silanes; D013242:Sterilization
D001843:Bone Cements; D020099:Coated Materials, Biocompatible; D012821:Silanes; D020366:Methylmethacrylate; C005625:monosilane