title: Protective effect of Pasteurella multocida cell-free antigen and toxoid against challenge with toxigenic strains of pasteurella multocida in mice.
abstract: The cell-free antigen (CFA) obtained from the culture supernatant of Pasteurella multocida (P. multocida) and the toxin (PMT) purified from CFA were inactivated and mixed with oil adjuvant to prepare a trial vaccine. Both of the mice immunized with CFA and PMT toxoid vaccine were noticeably protected against intratracheal challenge with toxigenic strains of P. multocida. Nevertheless, the protective indices of the mice immunized with CFA vaccine indicate that it is more protective and clears away the bacteria more promptly than in the mice immunized with PMT vaccine. The results suggested that CFA would possibly be good as an effective antigen to toxigenic strains of P. multocida infection.
authors.affiliation: Division of Veterinary Microbiology, Kyoto Biken Laboratories, Kyoto, Japan.
authors.forename: Chikara
authors.initials: C
authors.lastname: Uchida
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kimura
authors.forename: Sei
authors.initials: S
authors.lastname: Kubota
authors.forename: Osamu
authors.initials: O
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D051379:Mice; D010326:Pasteurella Infections / Q000517:prevention & control*; D016979:Pasteurella multocida / Q000276:immunology*; D014121:Toxoids / Q000276:immunology*; D014611:Vaccination
chemical_list: D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D014121:Toxoids