title: An extremely rare case of synchronous occurrence in the larynx of intravascular lymphoma and in situ squamous cell carcinoma.
abstract: We present the first case of laryngeal intravascular lymphoma coexisting with in situ squamous cell carcinoma. The patient, a 53 years old man, presented with hoarseness starting a year ago and underwent laryngoscopy, which revealed two nodular lesions on his right vocal cord. The histological and immunohistochemical examination of the biopsy specimens established the diagnosis of in situ squamous cell carcinoma coexisting with intravascular lymphoma of T-cell origin. Taking in consideration all the available references, the larynx has not until now been reported as a primary site of involvement of intravascular (angiotropic) lymphomas, nor as a secondary location in the systematic course of this disease. Furthermore no cases have been reported in the literature, concerning the synchronous affection of the larynx by this lymphoma and in situ laryngeal carcinoma, or other type of neoplasm.
authors.affiliation: Department of Pathology, Medical School, Aristotle University of Thessaloniki, P.O. Box 54006, Thessaloniki, Greece.
authors.forename: Constantine G
authors.initials: CG
authors.lastname: Hadjileontis
authors.forename: Ioannis S
authors.initials: IS
authors.lastname: Kostopoulos
authors.forename: Vassiliki D
authors.initials: VD
authors.lastname: Kaloutsi
authors.forename: Angelos C
authors.initials: AC
authors.lastname: Nikolaou
authors.forename: Vassiliki A
authors.initials: VA
authors.lastname: Kotoula
authors.forename: Constantine S
authors.initials: CS
authors.lastname: Papadimitriou
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001706:Biopsy; D002278:Carcinoma in Situ / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D003520:Cyclophosphamide / Q000008:administration & dosage; D015251:Epirubicin / Q000008:administration & dosage; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008223:Lymphoma / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D013997:Time Factors; D016896:Treatment Outcome; D019043:Vascular Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D015703:Antigens, CD; D015251:Epirubicin; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone