title: The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts.
abstract: In a multi-ethnic cohort we analyzed the Saitohin (STH) gene 'Q7R' polymorphism in 200 late-onset Alzheimer's disease cases (LOAD), 60 Parkinson's disease cases with dementia (PDD), 84 Parkinson's disease cases without dementia and 458 controls. We found no significant differences in genotype or allele frequencies when LOAD or PD cases were compared to controls. Ethnic differences in STH genotype frequencies for cases and controls were observed and these were statistically significant (cases n=344, P<0.03; controls n=458, P<0.001). We also observed a trend in non-Hispanic white PDD cases with the STH 'QQ' (Tau H1/H1) genotype increased (76%) compared to PD cases without dementia (61.7%) and controls (56.6%); however, this difference was not statistically significant (PDD vs. controls OR 2.1; 95% CI: 0.8-5.8, P=0.2).
authors.affiliation: Department of Pathology, Columbia University, New York, NY, USA. lc654@columbia.edu
authors.forename: Lorraine N
authors.initials: LN
authors.lastname: Clark
authors.forename: Gilberto
authors.initials: G
authors.lastname: Levy
authors.forename: Ming-Xin
authors.initials: MX
authors.lastname: Tang
authors.forename: Helen
authors.initials: H
authors.lastname: Mejia-Santana
authors.forename: Alejandra
authors.initials: A
authors.lastname: Ciappa
authors.forename: Benjamin
authors.initials: B
authors.lastname: Tycko
authors.forename: Lucien J
authors.initials: LJ
authors.lastname: Cote
authors.forename: Elan D
authors.initials: ED
authors.lastname: Louis
authors.forename: Richard
authors.initials: R
authors.lastname: Mayeux
authors.forename: Karen
authors.initials: K
authors.lastname: Marder
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000208:ethnology / Q000235:genetics*; D044383:Black People / Q000235:genetics; D005260:Female; D006239:Haplotypes; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics; D016875:tau Proteins / Q000235:genetics*; D001741:Black or African American
chemical_list: C458340:STH protein, human; D016875:tau Proteins