[Toxicity and anti-tumour efficacy of oxaliplatin on Glasgow osteosarcoma induced in mice: a mathematical model].
To study time-scheduled regimens in the treatment of tumours by cytotoxic drugs delivered by IV injection, we propose a mathematical model of the action of a chemotherapy on the population of tumoral cells on the one hand, on a population of fast renewing healthy cells on the other hand. We chose for model parameter identification the treatment by oxaliplatin of Glasgow Osteosarcoma in mice.
Clairambault
Jean
J
Université Paris VIII, Inria et Inserm 78153, Rocquencourt, France. jean.clairambault@inria.fr
Claude
Daniel
D
Filipski
Elisabeth
E
Granda
Teresa
T
Lévi
Francis
F
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use* / Q000633:toxicity; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor / Q000637:transplantation; D019454:Chronotherapy; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects; D007583:Jejunum / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000187:drug effects; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use* / Q000633:toxicity; D012516:Osteosarcoma / Q000188:drug therapy* / Q000473:pathology; D000077150:Oxaliplatin
D018906:Antineoplastic Agents, Alkylating; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin