Impaired fasting glucose and impaired glucose tolerance in women with prior gestational diabetes are associated with a different cardiovascular profile.
OBJECTIVE
The purpose of this study was to investigate the association of cardiovascular risk factors to impaired glucose tolerance (IGT) and to impaired fasting glucose (IFG) in women with prior gestational diabetes mellitus (GDM).


METHODS
We studied 838 women with prior GDM. Postpartum glucose tolerance status was classified as normal, IFG, IGT, IFG plus IGT, and diabetes according to the World Health Organization criteria. Postpartum BMI, waist circumference, blood pressure, triglyceride, cholesterol, and HDL cholesterol were assessed.


RESULTS
BMI and blood pressure were significantly higher in women with IFG than in women with normal glucose status. BMI and waist circumference were significantly higher in women with IFG plus IGT than in women with normal glucose status. No differences were observed between women with IGT and normal glucose status. The prevalence of hypertension and obesity was significantly increased in IFG compared with normal glucose status. The prevalence of obesity and abnormal lipids was significantly increased in IFG plus IGT compared with normal glucose status. IGT showed no increased prevalence of cardiovascular risk factors.


CONCLUSIONS
Traditional cardiovascular risk factors have a stronger association with isolated IFG than with isolated IGT in women with prior GDM.
Pallardo
Luis Felipe
LF
Department of Endocrinology, Division of Diabetes, Hospital Universitario La Paz, Madrid, Spain. lfpallardo.hulp@salud.madrid.org
Herranz
Lucrecia
L
Martin-Vaquero
Pilar
P
Garcia-Ingelmo
Teresa
T
Grande
Cristina
C
Jañez
Mercedes
M
D000328:Adult; D001786:Blood Glucose; D001794:Blood Pressure; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology; D016640:Diabetes, Gestational / Q000097:blood / Q000453:epidemiology*; D005215:Fasting; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000453:epidemiology*; D006801:Humans; D009765:Obesity; D049590:Postpartum Period; D011237:Predictive Value of Tests; D011247:Pregnancy; D015995:Prevalence; D012307:Risk Factors
D001786:Blood Glucose