title: Comparison of histological and ultrastructural changes in mice organs after supplementation with inorganic and organic selenium.
abstract: Two organic compounds of selenium, 4-o-totyl-selenosemicarbazide p-chlorobenzoic acid (chain compound) produced at the Chemistry Department of the University Medical School in Lublin, and one inorganic compound of sodium IV selenite (Na(2)SeO(3)) were used. The preparations were used per os in doses of 1 mg/kg body weight and 0.5 mg/kg body weight. The studies were conducted on female Swiss mice, covering seven groups of animals, i.e. 6 experimental and 1 control. Histopathologic changes were observed in liver, kidney, lung and heart. Ultrastructural changes were observed in liver and kidney. Our studies indicate a dose-dependent effect of selenium on histopathologic and ultrastructural changes. It is possible therefore, that the extent of excess of selenium exerts a greater influence on a cell than the form of supplemented selenium.
authors.affiliation: Department of Pathomorphology, Institute of Agricultural Medicine, P.O.Box 185, 20-950 Lublin, Poland.
authors.forename: Sabina
authors.initials: S
authors.lastname: Tos-Luty
authors.forename: Daniela
authors.initials: D
authors.lastname: Obuchowska-Przebirowska
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Latuszynska
authors.forename: Irena
authors.initials: I
authors.lastname: Musik
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Tokarska-Rodak
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D051379:Mice; D009206:Myocardium / Q000473:pathology; D016566:Organoselenium Compounds / Q000009:adverse effects* / Q000737:chemistry; D012643:Selenium / Q000009:adverse effects* / Q000737:chemistry
chemical_list: D016566:Organoselenium Compounds; D012643:Selenium