title: Structure, function and evolution of the signal recognition particle.
abstract: The signal recognition particle (SRP) is a ribonucleoprotein particle essential for the targeting of signal peptide-bearing proteins to the prokaryotic plasma membrane or the eukaryotic endoplasmic reticulum membrane for secretion or membrane insertion. SRP binds to the signal peptide emerging from the exit site of the ribosome and forms a ribosome nascent chain (RNC)-SRP complex. The RNC-SRP complex then docks in a GTP-dependent manner with a membrane-anchored SRP receptor and the protein is translocated across or integrated into the membrane through a channel called the translocon. Recently considerable progress has been made in understanding the architecture and function of SRP.
authors.affiliation: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. kn@mrc-lmb.cam.ac.uk
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Nagai
authors.forename: Chris
authors.initials: C
authors.lastname: Oubridge
authors.forename: Andreas
authors.initials: A
authors.lastname: Kuglstatter
authors.forename: Elena
authors.initials: E
authors.lastname: Menichelli
authors.forename: Catherine
authors.initials: C
authors.lastname: Isel
authors.forename: Luca
authors.initials: L
authors.lastname: Jovine
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism; D019143:Evolution, Molecular; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D011487:Protein Conformation; D021382:Protein Sorting Signals / Q000502:physiology; D021381:Protein Transport; D012270:Ribosomes / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D018271:Signal Recognition Particle / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; D021382:Protein Sorting Signals; D018271:Signal Recognition Particle