title: Evaluation of the clinical performances of a large NaI(Tl) crystal 3D PET scanner.
abstract: OBJECTIVE
  This study was aimed at assessing the clinical performances of a NaI(Tl) crystal 3D PET scanner, C-PET (ADAC-UGM), using a multi-ring 2D BGO PET scanner (multi-ring PET), as a reference.
  
  
  METHODS
  Thirty-seven oncological patients were studied in sequence with multi-ring PET and C-PET, within 30 days of a CT study. In order to assess the behaviour of C-PET in relation to acquisition count rate, patients were divided into 3 groups according to the count rate at the time of the C-PET scan acquisition. Group A (n=21): 3000-5000 kcounts/sec (recommended count rate range); Group B (n=8): <3000 Kcounts/sec and Group C (n=8): >5000 Kcounts/sec.
  
  
  RESULTS
  The number of lesions detected by multi-ring PET and C-PET, classified according to size, was compared. For Group A and Group B there was a good agreement between C-PET and multi-ring PET in terms of lesion detectability (relative sensitivity: 99.9% and 96.0%, respectively), while for Group C the relative sensitivity of C-PET was 61.9%.
  
  
  CONCLUSIONS
  Optimal performances of the C-PET scanner can thus be obtained at a count rate within or below the recommended range. Despite a lower lesion/background contrast resulting from a high scatter and random noise, the sensitivity of C-PET in detecting hypermetabolic lesions is comparable to that of multi-ring PET. These findings are discussed in relation to the physical performance of the two scanners and particularly in relation to the 3D vs 2D acquisition modality.
authors.affiliation: Department of Nuclear Medicine, Scientific Institute H. S. Raffaele, University of Milano-Bicocca, IBFM-CNR, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Picchio
authors.forename: A
authors.initials: A
authors.lastname: Savi
authors.forename: M
authors.initials: M
authors.lastname: Lecchi
authors.forename: C
authors.initials: C
authors.lastname: Landoni
authors.forename: L
authors.initials: L
authors.lastname: Gianolli
authors.forename: M
authors.initials: M
authors.lastname: Brioschi
authors.forename: C
authors.initials: C
authors.lastname: Rossetti
authors.forename: M C
authors.initials: MC
authors.lastname: Gilardi
authors.forename: F
authors.initials: F
authors.lastname: Fazio
mesh_terms: D000328:Adult; D000368:Aged; D019544:Equipment Failure Analysis; D019788:Fluorodeoxyglucose F18; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation* / Q000379:methods; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012974:Sodium Iodide; D014055:Tomography, Emission-Computed / Q000295:instrumentation* / Q000379:methods; D014159:Transducers
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D012974:Sodium Iodide