Age-related effects on induction of DNA strand breaks by intermittent exposure to electromagnetic fields.
Several studies indicating a decline of DNA repair efficiency with age raise the question, if senescence per se leads to a higher susceptibility to DNA damage upon environmental exposures. Cultured fibroblasts of six healthy donors of different age exposed to intermittent ELF-EMF (50 Hz sinus, 1 mT) for 1-24 h exhibited different basal DNA strand break levels correlating with age. The cells revealed a maximum response at 15-19 h of exposure. This response was clearly more pronounced in cells from older donors, which could point to an age-related decrease of DNA repair efficiency of ELF-EMF induced DNA strand breaks.
Ivancsits
Sabine
S
Division of Occupational Medicine, University of Vienna, University Hospital/AKH, Waehringer Guertel 18-20, A-1090 Vienna, Austria. sabine.ivancsits@akh-wien.ac.at
Diem
Elisabeth
E
Jahn
Oswald
O
Rüdiger
Hugo W
HW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002478:Cells, Cultured; D002648:Child; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology; D004574:Electromagnetic Fields / Q000009:adverse effects*; D005260:Female; D005347:Fibroblasts / Q000502:physiology* / Q000528:radiation effects; D006801:Humans; D008297:Male; D008875:Middle Aged