title: Sequential VATS lung volume reduction surgery: prolongation of benefits derived after the initial operation.
abstract: OBJECTIVE
  Sequential lung volume reduction (LVR) is thought to provide additional and prolonged benefit compared with unilateral LVR. We tested this hypothesis by reviewing physiological, subjective and survival outcome data on patients who underwent sequential or unilateral LVR.
  
  
  METHODS
  LVR was performed as a unilateral video-assisted thoracoscopic surgery (VATS) procedure, with bilateral reduction being undertaken in a staged manner. Pulmonary function data were collected prospectively. A telephone survey of patients and general practitioners was used to determine quality of life and survival.
  
  
  RESULTS
  Fifty patients underwent LVR. Twenty-one patients had staged reduction of the contra-lateral lung at a median interval of 9 months. Pre-operatively, patients undergoing sequential LVR were not significantly different from patients undergoing unilateral LVR: forced expiratory volume in 1 s (FEV1) 23% predicted vs. 27% predicted, KCO 40% vs. 45%, total lung capacity (TLC) 124% vs. 121%, residual volume (RV) 217% vs. 214%, health score 34.5 vs. 30.8. After single-side LVR, both groups demonstrated equivalent and significant improvement in spirometric and subjective health scores: FEV1 +15% predicted (P<0.01), TLC -5% (P=0.03), health score +80% (P<0.01). Patients undergoing sequential reduction demonstrated no further significant improvements using either an intragroup comparison with their pre-second operation values or an intergroup comparison with the unilateral LVR patients. However, sequential LVR appeared to prolong the benefits experienced after the initial surgery by 1 year. Overall, 12 patients (24%) died during follow-up with no survival difference between the two groups (P=0.65).
  
  
  CONCLUSIONS
  Sequential LVR is a safe strategy. Undertaking LVR to the second side does not further improve spirometric or subjective performance but does prolong the benefits achieved with the initial reduction.
authors.affiliation: Department of Cardiothoracic Surgery, Edinburgh Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, UK.
authors.forename: S Y
authors.initials: SY
authors.lastname: Soon
authors.forename: G
authors.initials: G
authors.lastname: Saidi
authors.forename: M L H
authors.initials: ML
authors.lastname: Ong
authors.forename: A
authors.initials: A
authors.lastname: Syed
authors.forename: M
authors.initials: M
authors.lastname: Codispoti
authors.forename: W S
authors.initials: WS
authors.lastname: Walker
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D011656:Pulmonary Emphysema / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D012086:Reoperation; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D020775:Thoracic Surgery, Video-Assisted; D016896:Treatment Outcome