Synthesis of poly(ethylene glycol) with sulfadiazine and chlorambucil end groups and investigation of its antitumor activity.
alpha-Amino-omega-hydroxyl-poly(ethylene glycol) (PEG) with different molecular weight (M(r)=2100, 4400, 7200) were synthesized and used as carrier for the combination of sulfadiazine and chlorambucil. In vivo, all these polymer drugs with sulfadiazine and chlorambucil at each end are water soluble and showed the higher antitumor activity against Lewis lung cancer than the same polymers but without the sulfadiazine. The best one is the sample with molecular weight of 2100. In vitro, however, for the samples with same molecular weights, the polymer drugs with and without sulfadiazine showed the similar results against C6 human breast cancer cells. No obvious difference was found.
Jia
Zhongfan
Z
The Key Laboratory of Molecular Engineering, Education Ministry of China, Department of Macromolecular Science, Fudan University, Shaghai 200433, People's Republic of China.
Zhang
Haitao
H
Huang
Junlian
J
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy; D045744:Cell Line, Tumor; D002699:Chlorambucil / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D004337:Drug Carriers / Q000138:chemical synthesis*; D015195:Drug Design; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008970:Molecular Weight; D009368:Neoplasm Transplantation; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013411:Sulfadiazine / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use
D000970:Antineoplastic Agents; D004337:Drug Carriers; D007202:Indicators and Reagents; C482466:alpha-Amino-omega-hydroxyl-poly(ethylene glycol); D013411:Sulfadiazine; D002699:Chlorambucil; D011092:Polyethylene Glycols