General pharmacology of indole [2',3':3,4]pyrido[2,1-b]quinazolinium- 5,7,8,13-tetrahydro-14-methyl-5-oxo-chloride, a new anti-dementia agent.
The general pharmacological properties of indolo[2',3':3,4]pyrido[2,1-b]quinazolinium-5,7,8,13-tetrahydro-14- methyl-5-oxo-chloride (dehydroevodiamine-HCl, DHED, CAS 67909-49-3), a new potential anti-dementia agent, were studied to investigate side effects using various experimental animals. Both oral and intraperitoneal administration of DHED had no effects on the central nervous system except that they showed an analgesic activity. DHED had no significant effect on heart rate, blood pressure and coronary flow in isolated rat hearts. DHED had negligible effects on the autonomic nervous system and smooth muscle in isolated rat ileum, rat vas deferens and rat aorta. DHED did not influence the gastrointestinal system except that it inhibited the intestinal travel of a charcoal meal in mice. Neither blood coagulation mechanism nor liver function was affected by DHED. Therefore, it is concluded from these general pharmacological studies that DHED does not induce any serious side effects at the dose levels showing anticholinesterase and memory enhancing activities in the experimental animals.
Park
Cheol Hyoung
CH
Department of Pharmacology, College of Medicine, National Creative Research Initiative Centre for Alzheimer's Dementia, Neuroscience Research Institute, MRC, Seoul National University, Seoul, Korea.
Choi
Se Hoon
SH
Kim
Chan-Hyung
CH
Seo
Ji-Heui
JH
Koo
Ja Wook
JW
Rah
Jong-Cheol
JC
Kim
Hye-Sun
HS
Jeong
Sung-Jin
SJ
Joo
Wan-Seok
WS
Lee
Young-Jae
YJ
Kim
Yong Sik
YS
Kim
Myung-Suk
MS
Suh
Yoo-Hun
YH
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D003704:Dementia / Q000188:drug therapy*; D004064:Digestive System / Q000187:drug effects; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009130:Muscle, Smooth / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D012137:Respiratory System / Q000187:drug effects
D000470:Alkaloids; C028633:dehydroevodiamine