title: Large granular lymphocytosis, lymphocyte subset inversion, thrombocytopenia, dysproteinemia, and positive Ehrlichia serology in a dog.
abstract: A 7-year-old, mixed-breed dog was presented for evaluation of a possible lymphocytic leukemia. Results of laboratory testing included thrombocytopenia, large granular lymphocytosis, inverted CD4:CD8 ratio, hyperglobulinemia, and hypoalbuminemia. Results of a tick-borne disease panel indicated a positive immunoglobulin G serum titer (1:2,048) to Ehrlichia canis, supporting exposure to this organism. The dog responded to a combination treatment of doxycycline and prednisone. A review of the literature and novel diagnostic methods that aided in the diagnosis of this case are discussed.
authors.affiliation: Department of Clinical Sciences, Kansas State University, 106A Mosier Hall, 1800 Denison Avenue, Manhattan, Kansas 66506, USA.
authors.forename: Heather L
authors.initials: HL
authors.lastname: Heeb
authors.forename: Melinda J
authors.initials: MJ
authors.lastname: Wilkerson
authors.forename: Ruthanne
authors.initials: R
authors.lastname: Chun
authors.forename: Roman Reddy
authors.initials: RR
authors.lastname: Ganta
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D004285:Dogs; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use; D041061:Ehrlichia canis / Q000276:immunology* / Q000302:isolation & purification; D016873:Ehrlichiosis / Q000175:diagnosis / Q000662:veterinary*; D005260:Female; D007074:Immunoglobulin G / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000175:diagnosis / Q000662:veterinary; D016131:Lymphocyte Subsets; D008218:Lymphocytosis / Q000662:veterinary; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000662:veterinary
chemical_list: D000900:Anti-Bacterial Agents; D007074:Immunoglobulin G; D004318:Doxycycline; D011241:Prednisone