[Antitumor effect of joint action of low intensity electromagnetic fields and ultra low doses of doxorubicin].
Combined action of a low intensive physical factor and a chemotherapeutic agent in ultralow doses against Lewis lung carcinoma was studied. Antitumor activity of low intensiwe electromagnetic field was expressed as inhibition of tumor growth at 60% compare to control. Ultra low doses of doxorubicin as well as its standard dose resulted in inhibition of tumor growth by 60-70% in comparison with control. Joint action of both factors leaded to increasing in the antitumor effect that reached such level of tumor growth inhibition as 85% relative to control.
Ostrovskaia
L A
LA
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119991 Russia. l.ostrovskaya@chph.ras.ru
Budnik
M I
MI
Korman
D B
DB
Bliukhterova
N V
NV
Fomina
M M
MM
Rykova
V A
VA
Burlakova
E B
EB
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000532:radiotherapy; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004317:Doxorubicin / Q000494:pharmacology*; D004574:Electromagnetic Fields; D051379:Mice; D008815:Mice, Inbred Strains; D011827:Radiation
D000970:Antineoplastic Agents; D004317:Doxorubicin