Manganese superoxide dismutase expression correlates with a poor prognosis in gastric cancer.
OBJECTIVE
The biologic significance of superoxide dismutase (SOD) in transformed gastric carcinoma cells is unclear. The aim of this study was to examine the role of SOD as a prognostic indicator of gastric carcinomas and its association with other clinicopathological factors.


METHODS
Expression of MnSOD and Cu/ZnSOD was evaluated immunohistochemically in gastric carcinomas and adenomas using tissue-array methods. The correlation between SOD immunoreactivity and clinical outcome or clinicopathological factors was investigated.


RESULTS
MnSOD expression was associated with a poor patient prognosis and was strong in advanced gastric cancer, in the well-differentiated type and in the presence of lymphoid stroma (p < 0.05). On the other hand, there was no association between Cu/ZnSOD expression and patient survival. Cu/ZnSOD immunoreactivity was strong in advanced gastric cancer and in the presence of lymphoid stroma (p < 0.05) and was weak in signet ring cell type.


CONCLUSIONS
MnSOD immunoreactivity is significantly associated with poor outcome in gastric carcinoma patients although both MnSOD and Cu/ZnSOD have a connection with several clinicopathological parameters with some overlap.
Kim
Jeong Jin
JJ
Department of Anatomy, College of Medicine, Seoul National University, Seoul, Korea.
Chae
Seoung Wan
SW
Hur
Gwong Cheung
GC
Cho
Sung Jin
SJ
Kim
Min Kyu
MK
Choi
Jimi
J
Nam
Seon Young
SY
Kim
Woo Ho
WH
Yang
Han-Kwang
HK
Lee
Byung Lan
BL
D000230:Adenocarcinoma / Q000201:enzymology* / Q000556:secondary / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D013482:Superoxide Dismutase / Q000378:metabolism*
D014408:Biomarkers, Tumor; D013482:Superoxide Dismutase