title: 2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel crf-1 receptor antagonists.
abstract: The discovery, synthesis and structure-activity studies of a novel series of 2-arylpyrimidin-4-ones as CRF-1 receptor antagonists is described. These compounds are structurally simple and display appropriate physical properties for CNS agents
authors.affiliation: Neurogen Corporation, 35NE Industrial Road, Branford, CT 06405, USA.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Hodgetts
authors.forename: Taeyoung
authors.initials: T
authors.lastname: Yoon
authors.forename: Jianhua
authors.initials: J
authors.lastname: Huang
authors.forename: Michael
authors.initials: M
authors.lastname: Gulianello
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kieltyka
authors.forename: Renee
authors.initials: R
authors.lastname: Primus
authors.forename: Robbin
authors.initials: R
authors.lastname: Brodbeck
authors.forename: Stéphane
authors.initials: S
authors.lastname: De Lombaert
authors.forename: Darío
authors.initials: D
authors.lastname: Doller
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D015195:Drug Design; D006801:Humans; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D008861:Microsomes / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D000099052:CRF Receptor, Type 1
chemical_list: D007202:Indicators and Reagents; D011743:Pyrimidines; D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1