[Chronobiological considerations for the management of human head and neck cancer].
The authors reviewed experimental and clinical data (ie, cell kinetics and its circadian control by cyclins, circadian expression of clock genes, chronotolerance to anticancer agents.) justifying to consider the temporal dimension in the medical treatment of human head and neck cancer. A complex infusional chronotherapyschedule (with 5-fluorouracil, folinic acid and carboplatin) was administered to 48 patients. Excellent tolerance and interesting tumour outcome allowed to conclude to an optimised therapeutic index.
Focan
C
C
Service d'oncologie médicale, clinique Saint-Joseph, rue de Hesbaye, 75, 4000, Liège, Belgique. christian.focan@lescliniquesstjoseph.be
Focan-Henrard
D
D
Kreutz
F
F
Moeneclaey
N
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D019090:Case Management; D019454:Chronotherapy; D002940:Circadian Rhythm; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D016190:Carboplatin; D002955:Leucovorin; D005472:Fluorouracil