Targeted delivery of mutant Raf kinase to neovessels causes tumor regression.
Hood
J D
JD
Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA.
Cheresh
D A
DA
D000818:Animals; D017209:Apoptosis; D004730:Endothelium, Vascular / Q000473:pathology; D018390:Gene Targeting; D016023:Integrins / Q000502:physiology; D051379:Mice; D009154:Mutation; D009374:Neoplasms, Experimental / Q000098:blood supply* / Q000473:pathology / Q000628:therapy*; D009389:Neovascularization, Pathologic / Q000628:therapy*; D019908:Proto-Oncogene Proteins c-raf / Q000008:administration & dosage* / Q000235:genetics*; D015398:Signal Transduction
D016023:Integrins; D019908:Proto-Oncogene Proteins c-raf