title: Total synthesis of apratoxin A.
abstract: Apratoxin A, a cyclodepsipeptide isolated from cyanobacterial Lyngbya spp, has been synthesized. The total synthesis features stereocontrolled access to the novel polyketide and the late-stage installation of the sensitive 2,4-disubstituted thiazoline moiety using an intramolecular Staudinger reduction/aza-Wittig process.
authors.affiliation: Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Jiehao
authors.initials: J
authors.lastname: Chen
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Forsyth
mesh_terms: D003603:Cytotoxins / Q000138:chemical synthesis*; D047630:Depsipeptides; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D003603:Cytotoxins; D047630:Depsipeptides; D010456:Peptides, Cyclic; C442201:apratoxin A