Association of anti-GM1 antibodies but not of anti-cytomegalovirus, Campylobacter jejuni and Helicobacter pylori IgG, with a poor outcome in Guillain-Barré syndrome.
Few reports exist on the influence of humoral immune responses, against microorganisms involved in infections preceding Guillain-Barré syndrome (GBS) and GM1, on clinical outcome. Nor is there any data on the relation between anti-Helicobacter pylori antibodies and prognosis in patients with GBS. To address these questions, we assayed and correlated serum anti-GM1 IgG and IgM and anti-H. pylori, anti-Campylobacter jejuni and anti-cytomegalovirus (CMV) IgG with duration of hospitalization of GBS patients and prognosis at discharge. Patients with anti-GM1 alone or associated with anti-H. pylori antibodies had significant longer hospitalization to reach a low clinical score at discharge than those without (P=0.004). A significant difference was also found for the association of anti-GM1 with anti-CMV antibodies (P=0.019). A weak but significant association of anti-GM1 and anti-C. jejuni antibodies with long hospitalization and worse prognosis at discharge was also found (P=0.02). The statistical significance increased when patients with anti-GM1 and anti-microorganism antibodies were compared with those displaying anti-H. pylori or anti-CMV only. These findings provide further evidence that the level of circulating anti-GM1 IgG plays a role in determining recovery from disability in GBS patients irrespective of other IgG against microorganisms causing infections preceding GBS.
Annunziata
Pasquale
P
Department of Neurological Sciences and Behaviour, University of Siena, Viale Bracci 2, 53100 Siena, Italy. annunziata@unisi.it
Figura
Natale
N
Galli
Rosita
R
Mugnaini
Floriano
F
Lenzi
Cristina
C
D000328:Adult; D000368:Aged; D002169:Campylobacter Infections / Q000097:blood / Q000276:immunology*; D016022:Case-Control Studies; D003586:Cytomegalovirus Infections / Q000097:blood / Q000276:immunology*; D004594:Electrophysiology / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016537:Gangliosidosis, GM1 / Q000097:blood / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000276:immunology*; D016481:Helicobacter Infections / Q000097:blood / Q000276:immunology*; D006760:Hospitalization; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D020078:Neurogenic Inflammation / Q000097:blood / Q000276:immunology; D012189:Retrospective Studies
D007074:Immunoglobulin G