Hyperacute rejection of living related kidney graft caused by IgG endothelial specific antibodies with a negative monocyte cross-match.
We present a case report of a 30-year-old man, who hyperacutely rejected a blood group identical, HLA-haploidentical living related kidney graft in spite of the fact that he had never been immunized. Anti-endothelial IgG antibodies that did not react with monocytes were detected with flow cytometry, on a panel of human umbilical cord cells in his serum retrospectively. On the basis of this experience we put for consideration the possibility of regular examination of non-HLA antibodies in potential living graft recipients.
Grandtnerová
Barbara
B
Slovak Center for Organ Transplantation Bratislava, Slovakia. barbarag@kiwwi.sk
Laca
L'udovít
L
Jahnová
Eva
E
Horváthová
Miroslava
M
Baláz
Vladimír
V
Hovoricová
Blanka
B
Hudec
Peter
P
Zarnovicanová
Mária
M
D000208:Acute Disease; D000328:Adult; D000906:Antibodies / Q000276:immunology*; D000918:Antibody Specificity; D004730:Endothelium, Vascular / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D016030:Kidney Transplantation / Q000276:immunology*; D019520:Living Donors; D008297:Male; D009000:Monocytes / Q000276:immunology*
D000906:Antibodies; D007074:Immunoglobulin G