A pediatric case of sclerodermatous chronic graft-versus-host disease.
We report a rare case of sclerodermatous chronic graft-versus-host disease (GVHD) in a 6-year-old boy that occurred after bone marrow transplantation for his aplastic anemia. The clinical manifestation and histopathologic findings were typical of scleroderma. Although various kinds of treatment have been tried for scleroderma, no established therapy exists. Furthermore, treating this disease is even more difficult in children. In the future, clarification of the pathogenesis of chronic GVHD and establishment of therapy will be necessary.
Terasaki
Kenjiro
K
Department of Dermatology, Kagoshima University, Faculty of Medicine, Kagoshima, Japan. ken0913@m2.kufm.kagoshima-u.ac.jp
Kanekura
Takuro
T
Setoyama
Mitsuru
M
Kanzaki
Tamotsu
T
D000741:Anemia, Aplastic / Q000601:surgery*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D045743:Scleroderma, Diffuse / Q000209:etiology* / Q000473:pathology* / Q000628:therapy