Progressive supranuclear palsy phenotype secondary to CADASIL.
OBJECTIVE
To report a unique case of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy manifesting as a progressive supranuclear palsy phenotype, thereby expanding its recognized presentations.


METHODS
Review of the pertinent literature from MEDLINE, cross-referencing cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, progressive supranuclear palsy, and parkinsonism. Description of a 60-year-old woman who presented with a several year history of step-wise, progressive parkinsonism secondary to cerebral autosomal dominant arteriopathy.


RESULTS
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy may present with a progressive supranuclear phenotype.


CONCLUSIONS
Parkinsonism, including a progressive supranuclear palsy phenotype, is one of a growing number of recognized ways that cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy may present.
Van Gerpen
J A
JA
Department of Neurology, Mayo Clinic Foundation, 200 First Street SW, Rochester, MN 55905, USA. vangerpen.jay@mayo.edu
Ahlskog
J E
JE
Petty
G W
GW
D015161:Dementia, Multi-Infarct / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013494:Supranuclear Palsy, Progressive / Q000209:etiology*; D013577:Syndrome