[Maternal insulin-dependent diabetes and congenital malformations in the newborn].
Congenital malformations (CM) are one of the leading causes of perinatal morbidity and mortality in infants of insulin dependent diabetic mothers (IDM). The aim of the present study is to determinate the incidence and structure of CM in this high risk population. The study included 14,325 newborns born between 1997-2000. 157 of them were IDM. The incidence of CM in IDM is 4-8 times higher than in general newborn population. The most frequent CM are congenital heart disease and polimalformation syndrome. The duration of mothers insulin dependent diabetes and poor glycemic control before and during pregnancy increases the risk of CM.
Kalaĭdzhieva
M
M
Popivanova
A
A
Doĭcheva
E
E
Nikolov
A
A
Dimitgrov
A
A
D000015:Abnormalities, Multiple / Q000453:epidemiology / Q000209:etiology; D001786:Blood Glucose / Q000378:metabolism; D000013:Congenital Abnormalities / Q000453:epidemiology* / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications*; D016640:Diabetes, Gestational / Q000097:blood / Q000150:complications*; D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood / Q000150:complications*; D012189:Retrospective Studies; D012307:Risk Factors; D013577:Syndrome
D001786:Blood Glucose