title: An autopsied case of dementia with Lewy bodies with supranuclear gaze palsy.
abstract: A 66-year-old man had suffered from a slow and steady decline in both physical and cognitive function for four years. He showed bradykinesia and small step gait with supranuclear vertical gaze palsy, especially upward gaze palsy. He was started on levodopa therapy but without response. A diagnosis of progressive supranuclear palsy was clinically suspected. He died at age 69. Pathologically, many alpha-synuclein positive inclusions were detected both in the brain stem and cerebral cortices, and the diagnosis of dementia with Lewy bodies was made. Scattered alpha-synuclein-positive inclusions and threads, which may be a pathological substrate for supranuclear gaze palsy, were identified in the rostal midbrain. From a review of five cases of dementia with Lewy bodies with supranuclear gaze palsy including this case, the absence of falls in the early stage of the disease, fluctuation of cognition, hallucination and vertical gaze palsy with a more severe defect in the upward direction distinguished dementia with Lewy bodies with vertical gaze palsy from progressive supranuclear palsy. In the differential diagnosis of parkinsonism with gaze palsy, clinicians should consider dementia with Lewy bodies with gaze palsy as well as progressive supranuclear palsy.
authors.affiliation: Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
authors.forename: Hanae
authors.initials: H
authors.lastname: Nakashima
authors.forename: Seishi
authors.initials: S
authors.lastname: Terada
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishizu
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Tanabe
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokota
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishihara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takata
authors.forename: Yuetsu
authors.initials: Y
authors.lastname: Ihara
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hayabara
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Kuroda
mesh_terms: D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D020961:Lewy Body Disease / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013494:Supranuclear Palsy, Progressive / Q000473:pathology*