Antioxidant activity of Thespesia populnea bark extracts against carbon tetrachloride-induced liver injury in rats.
Antioxidant activity of the aqueous (AET) and methanolic extracts (MET) of the Thespesia populnea bark was investigated in rats by inducing liver injury with carbon tetrachloride:olive oil (1:1). The extracts exhibited significant antioxidant activity showing increased levels of glutathione peroxidase (GPX), glutathione S-transferase (GST), glutathione reductase (GRD), superoxide dismutase (SOD) and catalase (CAT) and decreased level of lipid peroxidation (LPO). Thespesia populnea bark extracts, AET and MET, at a dose level of 500mg/kg showed significant antioxidant activity against carbon tetrachloride-induced liver injury in rats.
Ilavarasan
Raju
R
Department of Pharmacology, C. L. Baid Metha College of Pharmacy, Jyothi Nagar, Old Mahabalipuram Road, Thorapakkam, Chennai, 600096, India.
Vasudevan
Mani
M
Anbazhagan
Sockalingam
S
Venkataraman
Subramanian
S
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D019660:Malvaceae / Q000737:chemistry*; D000432:Methanol; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D014867:Water
D000975:Antioxidants; D010936:Plant Extracts; D014867:Water; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D000432:Methanol