[Effect of prostaglandin E1 infusion during and after total hip arthroplasty under hypotensive anesthesia on postoperative renal function and urine volume].
BACKGROUND
We evaluated the effect of prostaglandin E1 (PGE1) on the renal function and urine volume after total hip arthroplasty (THA).


METHODS
Twenty patients with normal renal function were randomly divided into two groups. The patients were anesthetized with spinal anesthesia using 0.5% bupivacaine 4 ml and epidural anesthesia. The laryngeal mask was inserted after administrations of 1.5-2 mg.kg-1 of propofol and 0.8 mg.kg-1 of suxamethonium. PGE1 was infused in the PGE1 group at a rate of 0.01 microgram.kg-1.min-1 (PGE1 group) during and after the operation (60-80 hrs). BUN and Crt values were evaluated before, and at the end of operation, and on 1, 4, and 7 postoperative days in each group. The amount of urine volume was measured at the end of operation and on 0, 1, 2, 3, and 4 postoperative days in each group.


RESULTS
BUN and Crt values after the operation did not differ significantly between the two groups. The amounts of urine volume on 2, 3, and 4 postoperative days in PGE1 group were significantly higher than those in the control group. Moreover, total urine volume in PGE1 group was significantly higher than that in the control group.


CONCLUSIONS
These results suggest that PGE1 may prevent postoperative decrease of urine volume, but it may not affect postoperative renal function.
Ikeya
Kazumori
K
Department of Anesthesia, Yamanashi Red Cross Hospital, Yamanashi 401-0301.
Kashimoto
Satoshi
S
Kumazawa
Teruo
T
D000368:Aged; D000527:Alprostadil / Q000494:pharmacology*; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D019644:Arthroplasty, Replacement, Hip; D001806:Blood Urea Nitrogen; D006801:Humans; D007023:Hypotension, Controlled; D007668:Kidney / Q000502:physiology*; D008875:Middle Aged; D011184:Postoperative Period; D014556:Urine
D000527:Alprostadil