title: Anthelmintic activity of 13-alkoxy milbemycin derivatives.
abstract: A number of 13-alkoxy milbemycin derivatives were synthesized to evaluate their anthelmintic activity. We report the strategy for developing a potent anthelmintic product, 13-[4-(N-methanesulfonyl-N-methylamino)-phenylethyloxy]milbemycin. The details of the structure-activity relationships of those derivatives are also discussed.
authors.affiliation: Medicinal Chemistry Research Lab. and Intellectual Property Department Sankyo Co., Ltd., 2-58 Hiromachi 1-chome, Shinagawa-ku, Tokyo 140-8710, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: Makio
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Akio
authors.initials: A
authors.lastname: Saito
mesh_terms: D000871:Anthelmintics / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018942:Macrolides; D013329:Structure-Activity Relationship
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D018942:Macrolides; C027837:moxidectin