title: N,N',N"-tris(dihydroxyphosphorylmethyl)-1,4,7-triazacyclononane (Deofix) - a high-affinity, high-specificity chelator for first transition series metal cations with significant deodorant, antimicrobial, and antioxidant activity.
abstract: Deofix, N,N',N"-tris(dihydroxyphosphorylmethyl)-1,4,7-triazacyclononane, is a high-affinity, high-specificity chelator for first transition series cations such as iron, zinc, manganese, and copper. A 1% solution in 50% ethanol was found to be significantly better at reducing underarm malodor than a solution of 0.3% Triclosan in 50% ethanol. Compared to a 50% alcohol control, Deofix was found to produce a significant reduction in malodor for at least 48 hours. Deofix appears to work by reducing the concentration of first transition series metal ions below the levels needed for microbial cell reproduction and by inhibiting oxidative processes by interfering with catalytic formation of free radicals. Deofix has very low levels of toxicity when measured via a number of screening techniques.
authors.affiliation: Complexx R and D Services, Keren Hayesod St., Bldg. 6, Tirat Carmel 39026, Israel.
authors.forename: Karl
authors.initials: K
authors.lastname: Laden
authors.forename: Haim
authors.initials: H
authors.lastname: Zaklad
authors.forename: Elliot D
authors.initials: ED
authors.lastname: Simhon
authors.forename: Joseph Y
authors.initials: JY
authors.lastname: Klein
authors.forename: Rosa L
authors.initials: RL
authors.lastname: Cyjon
authors.forename: Harry S
authors.initials: HS
authors.lastname: Winchell
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology; D002412:Cations; D002460:Cell Line; D002614:Chelating Agents / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology; D003836:Deodorants / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology; D006573:Heterocyclic Compounds, 1-Ring / Q000009:adverse effects / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008670:Metals / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D002412:Cations; D002614:Chelating Agents; D003836:Deodorants; D006573:Heterocyclic Compounds, 1-Ring; D008670:Metals; C477078:N,N',N''-tris(dihydroxyphosphorylmethyl)-1,4,7-triazacyclononane