The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function.
Physiological roles for postsynaptic molecules in synaptogenesis and plasticity are under intense investigation. Recent imaging experiments, including GFP-based and single-particle tracking strategies, reveal rapid movement of synaptic components to and from the postsynaptic sites. Furthermore, specific patterns of neuronal activity and/or activation of specific transmitter receptors trigger selective translocation of postsynaptic components. These emerging dynamic properties of synaptic specializations add another layer of complexity to the signaling mechanisms of CNS synapses.
Inoue
Akihiro
A
Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Okabe
Shigeo
S
D000818:Animals; D006801:Humans; D017729:Presynaptic Terminals / Q000737:chemistry / Q000378:metabolism; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D017470:Receptors, Glutamate / Q000737:chemistry / Q000378:metabolism; D013569:Synapses / Q000737:chemistry* / Q000378:metabolism*
D011506:Proteins; D017470:Receptors, Glutamate