title: Electron microscopic localization of Nogo-A at the postsynaptic active zone of the rat.
abstract: Our previous study has demonstrated intraneuronal localization of Nogo-A in motoneurons of the adult rat spinal cord. In the present study, we wished to explore Nogo-A immunoreactivity at synapses using pre-embedding and post-embedding immunogold cytochemistry. Immunogold particles for Nogo-A could be identified in dendrites of the spinal cord motoneurons. Some Nogo-A immunogold particles were found in close apposition to the postsynaptic density and the postsynaptic dense bodies at both symmetric and asymmetric synapses. The present finding of Nogo-A at the postsynaptic active zone provides a morphological basis for the possibility that the Nogo-A-Nogo receptor system may contribute to structural plasticity at synapses as well as along the axonal pathway.
authors.affiliation: Institute of Neurosciences, The Fourth Military Medical University, 17 Chang Le Xi Road, Xi'an, 710032, PR China.
authors.forename: Ying Ying
authors.initials: YY
authors.lastname: Liu
authors.forename: Wei Lin
authors.initials: WL
authors.lastname: Jin
authors.forename: Hui Ling
authors.initials: HL
authors.lastname: Liu
authors.forename: Gong
authors.initials: G
authors.lastname: Ju
mesh_terms: D000818:Animals; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009046:Motor Neurons / Q000378:metabolism / Q000648:ultrastructure; D009185:Myelin Proteins / Q000378:metabolism*; D000070798:Nogo Proteins; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000378:metabolism / Q000648:ultrastructure; D013569:Synapses / Q000378:metabolism*
chemical_list: D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603197:Rtn4 protein, rat