title: [Anemia and chemotherapy].
abstract: Anemia is a real and frequent complication during the management of cancer patients. It is define as a decrease of the erythrocyte mass. The hemoglobin rate (which was an estimation of this erythrocyte mass) is the most often using criteria. The inferior threshold change with the sex and the age of the patients. This is 13 g/dl for the men and 11.5 g/dl for the women. This rate would be however decrease without any other associated pathology. This anemia is due to nutritional context of the patients and complications of the cancer pathology or his management (treatments). Anemia due to the chemotherapy toxicity is a real problem to investigate, to quantify, to prevent or to treat. The chemotherapy toxicity worsened previous anemia (inflammatory ethiology) which physiopathology is multifactoriel and depends on drugs, patients' characteristics, and sort of cancer. Anemia is also a therapeutic problem. Whatever is the severity of the anemia, impact on the quality of life with physical and social consequences is clear. In addition, anemia could relieve of specific treatment such as blood transfusion or preventive treatment with recombinant erythropoietin.
authors.affiliation: Centre Léon-Bérard, 28, rue Laennec, 69008 Lyon.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Ray-Coquard
authors.forename: Thomas
authors.initials: T
authors.lastname: Bachelot
authors.forename: Catherine
authors.initials: C
authors.lastname: Sebban
authors.forename: Pierre
authors.initials: P
authors.lastname: Biron
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Guastalla
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Blay
mesh_terms: D000367:Age Factors; D000740:Anemia / Q000097:blood / Q000139:chemically induced* / Q000628:therapy; D000970:Antineoplastic Agents / Q000009:adverse effects*; D017707:Erythrocyte Transfusion; D004921:Erythropoietin / Q000627:therapeutic use; D005260:Female; D006454:Hemoglobins; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy*; D011788:Quality of Life; D011994:Recombinant Proteins; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D000970:Antineoplastic Agents; D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin