Cell immortality and hallmarks of cancer.
In growth-limiting conditions, cells that express telomerase and inactivate tumor suppressors have a selective advantage due to resistance to growth arrest. Accidentally such cells become immortal.
Blagosklonny
Mikhail V
MV
Brander Cancer Research Institute New York Medical College 19 Bradhurst Ave, Suite 2400 Hawthorne, New York 10532, USA. M_Blagosklonny@NYMC.EDU
D000818:Animals; D002455:Cell Division / Q000502:physiology; D002470:Cell Survival / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D016922:Cellular Senescence / Q000502:physiology; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D009154:Mutation; D009362:Neoplasm Metastasis / Q000235:genetics; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D009857:Oncogenes / Q000502:physiology; D019098:Telomerase / Q000235:genetics / Q000378:metabolism*
D006133:Growth Substances; D019098:Telomerase