title: Structure of the metabotropic glutamate receptor.
abstract: In the twelve years since the molecular elucidation of the metabotropic glutamate receptor subtype 1, a class III family of G-protein-coupled receptors has emerged; members of this family include the calcium-sensing receptor, the GABA(B) receptor, some odorant receptors and some taste receptors. Atomic structures of the ligand-binding core of the original metabotropic glutamate receptor 1 obtained using X-ray crystallography provide a foundation for determining the initial receptor activation of this important family of G-protein-coupled receptors.
authors.affiliation: Department of Molecular Biology, Biomolecular Engineering Research Institute, 6-2-3 Suita-City, Osaka 565-0874, Japan. jingami@beri.or.jp
authors.forename: Hisato
authors.initials: H
authors.lastname: Jingami
authors.forename: Shigetada
authors.initials: S
authors.lastname: Nakanishi
authors.forename: Kosuke
authors.initials: K
authors.lastname: Morikawa
mesh_terms: D000818:Animals; D001665:Binding Sites / Q000502:physiology; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D018094:Receptors, Metabotropic Glutamate / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D018094:Receptors, Metabotropic Glutamate; D018698:Glutamic Acid