Triclonal gammopathy in an extranodal non-Hodgkin lymphoma patient.
The case of a patient with an extranodal non-Hodgkin lymphoma and three M-components (IgGkappa + IgGlambda + IgMlambda) in the serum is described. Three separate populations of M-component producing cells have been identified. Since a kappa-->lambda chain switch is not demonstrated, the synthesis of IgGkappa and IgGlambda by two distinct clones is obvious. IgMlambda and IgGlambda M-components are synthesized by two different plasma cell populations that could represent two unrelated cell clones or, alternatively, two subclones originated by a common precursor. After chemotherapy the IgGlambda M-component is replaced by heavy gamma chains without evidence of lambda light chains.
Tirelli
Angelo
A
Department of Hematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Naples, Italy.
Guastafierro
Salvatore
S
Cava
Benedetto
B
Lucivero
Giacomo
G
D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001856:Bone Marrow Examination; D002999:Clone Cells / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007128:Immunoglobulin Fragments / Q000032:analysis; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D009101:Multiple Myeloma / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*
D000970:Antineoplastic Agents; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G; D007075:Immunoglobulin M