[Analysis of the poly-genes expression changes in liver by gene expression profile chip in gut ischemia-reperfusion rats].
OBJECTIVE
To investigate the difference of poly-genes expression between control and gut ischemia-reperfusion rats.


METHODS
One thousand one hundred and seventy-six known genes expression in the liver was investigated by means of the cDNA microarray technology to reveal the differential expression genes between control and gut ischemia-reperfusion rats.


RESULTS
The analysis data of the cDNA microarray showed that there were 111 genes expression changed over 5 times including 64 genes upregulated and 47 genes downregulated, some of which had not been reported to associated with gut ischemia-reperfusion injury.


CONCLUSIONS
There are many structural and functional genes expression changed in liver of gut ischemia-reperfusion rats, which might be involved in the initiation and the development of SIRS and MODS.
Lü
Yi
Y
Research Department of Burn Institute, 304th Hospital of People's Liberation Army, Beijing 100037, China.
Li
Jun-you
JY
Hu
Sen
S
Jin
Hua
H
Sun
Dan
D
Sheng
Zhi-yong
ZY
D000818:Animals; D015870:Gene Expression; D007410:Intestinal Diseases / Q000235:genetics* / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000235:genetics* / Q000378:metabolism; D059467:Transcriptome