title: [Familial susceptibility to aminoglycoside ototoxicity due to the A1555G mutation in the mitochondrial DNA].
abstract: OBJECTIVE
  The A1555G mutation in the mitochondrial genome causes sensorineural hearing loss and familial aminoglycoside ototoxicity.
  
  
  METHODS
  Screening for the A1555G mutation was performed on 72 patients with nonsyndromic sensorineural hearing loss.
  
  
  RESULTS
  The A1555G mutation was identified in 15 patients (20.8%). All of them presented maternal relatives with deafness. Individuals with the A1555G mutation that had been treated with aminoglycosides developed more severe hearing loss.
  
  
  CONCLUSIONS
  The A1555G mutation should be screened in individuals with maternal relatives with hearing loss before administering aminoglycosides.
authors.affiliation: Servicio de Otorrinolaringología. Hospital Marqués de Valdecilla. Santander. Cantabria. Spain.
authors.forename: Jaime
authors.initials: J
authors.lastname: Gallo-Terán
authors.forename: Carmelo
authors.initials: C
authors.lastname: Morales-Angulo
authors.forename: Ignacio
authors.initials: I
authors.lastname: del Castillo
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Moreno-Pelayo
authors.forename: Angel
authors.initials: A
authors.lastname: Mazón
authors.forename: Felipe
authors.initials: F
authors.lastname: Moreno
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D034381:Hearing Loss / Q000139:chemically induced* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010375:Pedigree
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004272:DNA, Mitochondrial