[Effect of fentanyl and morphine on local blood flow and tissue oxygen tension in cortical frontal-parietal area and nucleus accumbens in albino rats].
The aim of this study was to examine effects of i.p. injected Fentanyl (0.005 mg/kg) and Morphine (1 mg/kg) on local cerebral blood flow (ICBF) and tissue pO2 level in frontal-parietal area of the cortex and nucleus accumbens of the rat's brain. Either fentanyl or morphine injection resulted in significant increase of local blood flow in the n.accumbens and its decrease in frontal-parietal area of cortex. Measurement of oxygen partial pressure revealed the opposite (to ICBF) changes: a decrease in n.accumbens and its increase in cortical area of the brain. Analysis of this data and electrical activity recorded from both said structures allow to conclude that they are conditioned by respective changes in functional-metabolic activity induced by intraperitoneal injection either fentanyl or morphine: its suppression in frontal-parietal area of the cortex and development of seizure-like activity in the n.accumbens.
Nikolaĭshvili
L S
LS
I.S. Beritashvili Institute of Physiology, Georgian Acad. Sci., 14 Gotua St., Tbilisi 380060, Georgia.
Gobechiia
L Sh
LSh
Mitagvariia
N P
NP
D000200:Action Potentials / Q000187:drug effects; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005283:Fentanyl / Q000494:pharmacology; D005625:Frontal Lobe / Q000098:blood supply* / Q000378:metabolism; D008297:Male; D008839:Microelectrodes; D009020:Morphine / Q000494:pharmacology; D009714:Nucleus Accumbens / Q000098:blood supply* / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D010296:Parietal Lobe / Q000098:blood supply* / Q000378:metabolism; D051381:Rats
D000701:Analgesics, Opioid; D009020:Morphine; D010100:Oxygen; D005283:Fentanyl