MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress.
Saretzki
Gabriele
G
Institute of Aging and Health, Newcastle University, Newcastle upon Tyne NE4 6BE, UK.
Murphy
Michael P
MP
von Zglinicki
Thomas
T
D000975:Antioxidants / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D016922:Cellular Senescence / Q000187:drug effects*; D004249:DNA Damage; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D009154:Mutation; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010100:Oxygen / Q000494:pharmacology; D010545:Peroxides / Q000032:analysis; D016615:Telomere / Q000187:drug effects* / Q000648:ultrastructure; D014451:Ubiquinone / Q000031:analogs & derivatives
D000975:Antioxidants; D009943:Organophosphorus Compounds; D010545:Peroxides; D014451:Ubiquinone; C429014:mitoquinone; D010100:Oxygen