[Effect of fluvastatin and fenofibrate on the antioxidative barrier enzyme activity in patients with dyslipidemia].
The effect of fluvastatin and fenofibrate on antioxidative enzymatic activity in patients with stable angina and mixed hyperlipidaemia was investigated. Thirty-five patients (13 men and 22 women) aged 40-77 years, were randomly divided into two groups. The first group comprised 20 patients who were administered fluvastatin 40 mg once daily at bedtime for 30 days. The second group consisted of 15 patients who were administered fenofibrate 200 mg once daily at bedtime for 30 days. The control group comprised 11 clinically healthy persons aged 21-54 years. The activities of SOD-1, CAT and GSH-Px in erythrocytes were measured. Fluvastatin induced an increase of the activities of all investigated enzymes. Fenofibrate caused no change of enzyme activities in patients with dyslipidaemia.
Kowalski
Jan
J
Klinika Chorób Płuc WAM w łodzi.
Olejniczak
Jarosław
J
Błaszczyk
Jan
J
Błaszczyk-Suszyńska
Joanna
J
Kowalski
Marcin
M
Petecka
Edyta
E
Kedziora
Józef
J
D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D011345:Fenofibrate / Q000494:pharmacology* / Q000627:therapeutic use*; D000077340:Fluvastatin; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D007211:Indoles / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000378:metabolism
D000924:Anticholesteremic Agents; D000975:Antioxidants; D005229:Fatty Acids, Monounsaturated; D000960:Hypolipidemic Agents; D007211:Indoles; D000077340:Fluvastatin; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D011345:Fenofibrate