title: Application of the Suzuki-Miyaura cross-coupling reaction for the modification of phenylalanine peptides.
abstract: We have demonstrated an exceptionally simple and a useful methodology for modification of unusual phenylalanine peptides by adapting the building block approach using the Suzuki-Miyaura cross-coupling reaction as a key step. This strategy gave a good overall yield of various modified tri- and pentapeptides that may be useful to prepare various biologically active peptides in a short period of time.
authors.affiliation: Department of Chemistry, Indian Institute of Technology-Bombay, Mumbai, 400 076, India. srk@chem.iitb.ac.in
authors.forename: Sambasivarao
authors.initials: S
authors.lastname: Kotha
authors.forename: Kakali
authors.initials: K
authors.lastname: Lahiri
mesh_terms: D020650:Combinatorial Chemistry Techniques; D003432:Cross-Linking Reagents / Q000737:chemistry*; D015195:Drug Design; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010649:Phenylalanine / Q000737:chemistry*
chemical_list: D003432:Cross-Linking Reagents; D010455:Peptides; D010649:Phenylalanine