Relationship between airway hyperresponsiveness to mannitol and adenosine monophosphate.
BACKGROUND
Assessment of airway hyperresponsiveness (AHR) to indirect bronchoconstrictor stimuli is a useful noninvasive tool in the evaluation of asthma and its treatment. We investigated the putative relationship in AHR between inhaled adenosine monophosphate and mannitol.


METHODS
Fifteen mild-to-moderate atopic asthmatics were evaluated. On two separate screening days, the threshold AMP concentration and threshold mannitol dose to provoke a given fall in FEV1 were measured.


RESULTS
For AMP PC20vs. mannitol PD15, the Pearsons correlation coefficient was 0.80, P < 0.001. For AMP PC15vs. mannitol PD15 and AMP PC10vs. mannitol PD10 corresponding values were 0.83, P < 0.001 and 0.68, P = 0.005.


CONCLUSIONS
There was a highly significant association between the threshold concentration of AMP and dose of mannitol causing a given fall in FEV1. Further studies are required to evaluate the relationship between inhaled mannitol and other surrogate inflammatory markers.
Currie
G P
GP
Asthma and Allergy Research Group, Ninewells University Hospital and Medical School, Dundee, UK.
Haggart
K
K
Brannan
J D
JD
Lee
D K C
DK
Anderson
S D
SD
Lipworth
B J
BJ
D000249:Adenosine Monophosphate; D000328:Adult; D000336:Aerosols; D001249:Asthma / Q000175:diagnosis / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000175:diagnosis*; D001985:Bronchial Provocation Tests; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008353:Mannitol; D008875:Middle Aged; D011208:Powders; D013147:Spirometry
D000336:Aerosols; D011208:Powders; D008353:Mannitol; D000249:Adenosine Monophosphate