[Influence of family history of hypertension on blood pressure in young healthy men].
Hypertension belongs to the most frequent illnesses of circulatory system and in regard for its spread in population and great effects determines one of the most important medical, social and economical problems. In spite of turbulent progress which took place in diagnostic methods pathogenesis of primary hypertension still remains not fully detected. There are many proofs, that the important role plays here genetical factor. The purpose of these studies were to find answer the question, if young men age between 18-30 years with family medical hypertension history have a difference in middle systolic, diastolic and mean blood pressure in comparison to coevals without familiar hypertension. Lipoid parameters such as: total cholesterol, and its fractions HDL and LDL and triglyceride were also studied to. In order to exclude some well-known factors but which have influence blood pressure of studies height, weight and body mass index were measured. All around a clock registration blood pressure was made by means of ERKA machine with frequency three times a hour in the daily activity (6 a.m.-10 p.m.) and one time a hour during the night (10 p.m.-6 a.m.), arranging in this way 57 time points (measuring points). Obtaining mean systolic, diastolic and mean BP were in reality higher in studying group (p < 0.05). As well as mean systolic, diastolic and mean BP as following time points in majority studies in all sort of BP were in reality higher in group with family hypertension history. Any major changes were obtained in instance of pulse amplitude, systolic, diastolic minimal and maximal blood pressure. Any major differences were observed in above described lipoid parameters. Height, weight, the body mass index establishing were almost the same (entrance examination). The following studies proved that in the age of 18-30 were strongly marked the differences in blood pressure. They are higher in young men with family hypertension history. It proves about undoubted genetical predisposition and contribution of this factor in pathogenesis of primary hypertension.
Balwierz
Paweł
P
Katedra i Klinika Chorób Wewnetrznych, Diabetologii i Nefrologii w Zabrzu.
Grzeszczak
Władysław
W
D000328:Adult; D018660:Blood Pressure Monitoring, Ambulatory; D016022:Case-Control Studies; D015716:Electrocardiography, Ambulatory; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D012016:Reference Values; D012307:Risk Factors; D013997:Time Factors