title: Remission as the critical outcome of depression treatment.
abstract: Major depressive disorder is currently the fourth largest contributor to the worldwide burden of disease. Direct and indirect costs associated with depression place a significant burden on the health care system and society. Despite the development of new antidepressant medications, the management of patients with depression remains a therapeutic challenge. Obtaining a response in antidepressant therapy-commonly defined in clinical trials as an improvement of >erotonergic and noradrenergic neurotransmission, will increase the likelihood of remission.
authors.affiliation: University of Pittsburgh Medical Center, Western Psychiatric Institute, Pittsburgh, Pennsylvania, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Thase
authors.forename: Diane M E
authors.initials: DM
authors.lastname: Sloan
authors.forename: Susan G
authors.initials: SG
authors.lastname: Kornstein
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy; D003865:Major Depressive Disorder / Q000188:drug therapy; D006801:Humans; D011613:Psychotherapy; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents