The relationship between the anticholinesterase effect of organophosphorous inhibitors and the extent of shielding (accessibility) of the phosphorus atom.
Rozengart
E V
EV
Sechenov Institute of Evolution, Physiology, and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 44, St. Petersburg, 194223 Russia.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006736:Horses; D006801:Humans; D007700:Kinetics; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000494:pharmacology*; D010758:Phosphorus / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D010758:Phosphorus; D000110:Acetylcholinesterase