Microencapsulation of lipid nanoparticles containing lipophilic drug.
A polymeric emulsion bead, which consists of core and capsule, was prepared. The core is composed of lipid nanoparticles containing lipophilic drug and semi-interpenetrating networks (semi-IPNs) are prepared to provide the capsule composed of sodium alginate and hydroxypropylmethyl cellulose (HPMC). The lipid nanoparticles were encapsulated into the polymeric emulsion bead with high drug loading efficiency, and lovastatin was used as a model drug. For the application as an oral drug delivery system, the enteric coating was performed with polymeric emulsion bead. The drug release pattern was controlled by the composition of capsule materials and environmental pH.
Lee
K E
KE
Department of Polymer Science and Engineering, Hannam University, 133 Ojeong Dong, Daedeog Ku, Taejeon, Korea 306-791.
Cho
S H
SH
Lee
H B
HB
Jeong
S Y
SY
Yuk
S H
SH
D000284:Administration, Oral; D000464:Alginates / Q000737:chemistry; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001672:Biocompatible Materials; D002214:Capsules / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D008148:Lovastatin / Q000008:administration & dosage / Q000493:pharmacokinetics; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D008863:Microspheres; D036103:Nanotechnology / Q000379:methods*
D000464:Alginates; D000924:Anticholesteremic Agents; D001672:Biocompatible Materials; D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D065347:Hypromellose Derivatives; D020723:Glucuronic Acid; D008747:Methylcellulose; D008148:Lovastatin