title: Prothrombotic gene polymorphisms and atherothrombotic cerebral infarction.
abstract: OBJECTIVE
  To test the hypothesis whether risk genotypes of the prothrombotic gene polymorphisms (I/D 4G5G PAI-1, G1691A factor V point mutation, factor VII Arg/Gln353) are risk factors for ACI in the Slovene population. The study sought an association between the insertion/deletion 4G/5G-plasminogen activator inhibitor 1 (PAI-1) gene polymorphism, the 1691G-A factor V point mutation or the arg353-to-gln factor VII gene polymorphism and atherothrombotic cerebral infarction (ACI).
  
  
  METHODS
  Ninety-six Slovene patients who suffered ACI were compared with 115 control subjects clinically free of cerebrovascular disease. Insertion/deletion 4G/5G PAI-1 gene polymorphism, 1691G-A factor V point mutation and arg353-to-gln polymorphism in the factor VII were determined using polymerase chain reaction.
  
  
  RESULTS
  The 4G4G genotype of 4G5G PAI-1 gene polymorphism was less frequent in cases (21.9%) than in controls (35.6%; OR = 0.5, 95% CI = 0.3-1; P = 0.033). No association was found either between the factor V point mutation (1691G-A) or the RR genotype of the factor VII Arg/Gln353 gene polymorphism and the risk of ACI using univariate analysis.
  
  
  CONCLUSIONS
  The 4G/4G-PAI-1 genotype might be a protective factor against ACI, whereas the factor V point mutation (1691G-A) and the factor VII Arg/Gln353 gene polymorphism have not proved to be risk factors for ACI.
authors.affiliation: Institute of Histology and Embryology, Medical Faculty Ljubljana, Ljubljana, Slovenia. daniel.petrovic@mf.uni-lj.si
authors.forename: D
authors.initials: D
authors.lastname: Petrovic
authors.forename: T
authors.initials: T
authors.lastname: Milanez
authors.forename: J
authors.initials: J
authors.lastname: Kobal
authors.forename: D
authors.initials: D
authors.lastname: Bregar
authors.forename: K P
authors.initials: KP
authors.lastname: Potisk
authors.forename: B
authors.initials: B
authors.lastname: Peterlin
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005167:Factor VII / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D017354:Point Mutation; D011110:Polymorphism, Genetic; D012307:Risk Factors; D017524:Slovenia
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D005165:Factor V; D005167:Factor VII