title: Blood leukocyte subsets are modulated in patients with endometriosis.
abstract: OBJECTIVE
  To determine whether blood leukocyte populations could be modulated in endometriosis.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Eight clinical institutions of the Montreal area.
  
  
  METHODS
  Women with regular menstrual cycles who underwent laparoscopy or laparotomy between 1997 and 2001 and who were not under hormonal treatment for at least 3 months were selected. This study includes 175 cases and 131 controls.
  
  
  METHODS
  The proportion of blood leukocytes expressing markers for T, B lymphocytes, monocytes, or natural killer (NK) cells were compared by flow cytometric analysis between cases and controls.
  
  
  RESULTS
  Age and parity were identified as important confounders. Given that smoking, history of acute infection, and previous use of oral contraceptives strongly correlate with the level of some blood leukocyte populations, these parameters were taken into account in addition with age and parity when the level of blood leukocyte subsets were evaluated in cases and controls. Blood monocytes expressing CD14 and CD44 molecules were increased in patients with endometriosis. Alternatively, B lymphocytes were shown to be significantly decreased in cases compared with controls.
  
  
  CONCLUSIONS
  Although these results suggest that endometriosis is associated with some systemic manifestations, the exact role of these modulations remains unclear.
authors.affiliation: Division of Research and Development, PROCREA BioSciences, Montréal, Québec, Canada.
authors.forename: Danièle
authors.initials: D
authors.lastname: Gagné
authors.forename: Michèle
authors.initials: M
authors.lastname: Rivard
authors.forename: Martin
authors.initials: M
authors.lastname: Pagé
authors.forename: Kamran
authors.initials: K
authors.lastname: Shazand
authors.forename: Patrice
authors.initials: P
authors.lastname: Hugo
authors.forename: Diane
authors.initials: D
authors.lastname: Gosselin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D004715:Endometriosis / Q000097:blood / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology*; D008875:Middle Aged; D010298:Parity