Aminoterminal pro-brain natriuretic peptide and ventricular filling pressures in heart transplant recipients.
We tested the hypothesis that, in heart transplant recipients, plasma aminoterminal pro-brain natriuretic peptide (NT-proBNP) dosage is useful for diagnosis of high ventricular loading pressures in the absence of systolic dysfunction. We studied 60 consecutive transplanted heart recipients without systolic dysfunction at 1 to 16 years after transplantation. We found that, in these patients with frequent high ventricular filling pressures, plasma NT-proBNP was highly correlated with creatininemia and not correlated with ventricular loading pressures. These results do not support the hypothesis that NT-proBNP is useful for diagnosis of isolated diastolic dysfunction in transplanted heart recipients.
Ambrosi
Pierre
P
Department of Cardiology, University Hospital, Marseille, France. pambrosi@ap-hm.fr
Oddoze
Christiane
C
Riberi
Alberto
A
Vailloud
Jean-Marie
JM
Aviérinos
Jean-François
JF
Bouvenot
Gilles
G
Portugal
Henri
H
Métras
Dominique
D
Habib
Gilbert
G
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood / Q000652:urine; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain; D009419:Nerve Tissue Proteins / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood*; D013223:Statistics as Topic; D013318:Stroke Volume / Q000187:drug effects / Q000502:physiology; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D017725:Ventricular Pressure / Q000502:physiology*
D015415:Biomarkers; D007166:Immunosuppressive Agents; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D011498:Protein Precursors; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D003404:Creatinine