Alveolar soft-part sarcoma responding to interferon alpha-2b.
A 23-year-old woman with an alveolar soft-part sarcoma of her calf with pulmonary metastases unresponsive to chemotherapy is described. Interferon (IFN) alpha-2b induced an impressive tumour response still ongoing after IFN treatment had to be stopped because of a psychosis. An explanation of this effect is still speculative.
Roozendaal
K J
KJ
Department of Haematology/Medical Oncology, Onze Lieve Vrouwe Gasthuis, Eerste Oosterparkstraat 179, 1090 HM Amsterdam, The Netherlands. K.J.Roosendaal@olvg.nl
de Valk
B
B
ten Velden
J J A
JJ
van der Woude
H J
HJ
Kroon
B B R
BB
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects / Q000494:pharmacology*; D011618:Psychotic Disorders / Q000209:etiology; D011994:Recombinant Proteins; D012509:Sarcoma / Q000188:drug therapy* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins