title: Acupuncture increases nitric oxide synthase expression in hippocampus of streptozotocin-induced diabetic rats.
abstract: In the present study, the effect of acupuncture at Zusanli acupoint on nitric oxide synthase (NOS) expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats was investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Animals were divided into four groups: the control group, the nondiabetic and acupunctured group, the STZ-induced diabetes group, and the STZ-induced diabetes and acupunctured group. From the results, NADPH-d-positive neurons in the hippocampus were decreased in STZ-induced diabetic rats, while acupuncture increased NOS expression significantly under diabetic conditions. In the present study, it can be suggested that acupuncture treatment may modulate NOS activity in the hippocampus under diabetic conditions.
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, Dongdaemoon-gu, Seoul, Korea.
authors.forename: Mi-Hyeon
authors.initials: MH
authors.lastname: Jang
authors.forename: Min-Chul
authors.initials: MC
authors.lastname: Shin
authors.forename: Baek-Vin
authors.initials: BV
authors.lastname: Lim
authors.forename: Hyun-Bae
authors.initials: HB
authors.lastname: Kim
authors.forename: Young-Pyo
authors.initials: YP
authors.lastname: Kim
authors.forename: Ee-Hwa
authors.initials: EH
authors.lastname: Kim
authors.forename: Hong
authors.initials: H
authors.lastname: Kim
authors.forename: Mal-Soon
authors.initials: MS
authors.lastname: Shin
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D026881:Acupuncture; D000818:Animals; D002452:Cell Count; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D006624:Hippocampus / Q000201:enzymology* / Q000502:physiology*; D006651:Histocytochemistry; D008297:Male; D009252:NADPH Dehydrogenase / Q000096:biosynthesis; D009474:Neurons / Q000201:enzymology; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D052248:Nitric Oxide Synthase Type I; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; C496322:Nos1 protein, rat; D009252:NADPH Dehydrogenase