[Proliferation and apoptosis of epithelium in prostate cancer, in a peritumor region, and in benign hyperplasia].
Indices of Ki67, Bc12 expression, mutant gene p53, nucleolar organizers activity and the percentage of cells having nucleic acids levels higher or lower of the diploid levels were determined in prostatic epithelium in cancer, in the peritumorous area and in the area of benign prostatic hyperplasia. A considerable variability of the tumor epithelium by the level of proliferative activity, apoptosis inhibition and expression of mutant p53 gene was established. Increased proliferative activity and predominance of epitheliocytes with a nucleic acids level higher as compared to the diploid one were revealed in the tumor epithelium. Low apoptosis inhibition and increased degradation of the epithelium in case of a high level of Ki-67 expression index were noted in the peritumorous area. Changes in the peritumorous region were noticed both very close to the tumor lesion as well as at considerable distance from it.
Fedosenko
K V
KV
St. Petersburg City Bureau of Pathology, 194354, St. Petersburg.
Koval'skiĭ
G B
GB
D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002455:Cell Division; D004848:Epithelium / Q000473:pathology; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008297:Male; D011467:Prostate / Q000378:metabolism / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000378:metabolism / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2