Monacolin N, a compound resulting from derailment of type I iterative polyketide synthase function en route to lovastatin.
A novel compound, monacolin N, has been isolated from fermentation cultures of Aspergillus nidulans in which the lovastatin polyketide synthase genes lovB and lovC are heterologously expressed.
Sorensen
John L
JL
Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada.
Vederas
John C
JC
D001233:Aspergillus nidulans / Q000201:enzymology / Q000235:genetics; D008148:Lovastatin / Q000096:biosynthesis / Q000737:chemistry*; D009097:Multienzyme Complexes / Q000096:biosynthesis / Q000737:chemistry*; D009281:Naphthalenes / Q000138:chemical synthesis / Q000737:chemistry*
D009097:Multienzyme Complexes; D009281:Naphthalenes; C477971:monacolin N; D008148:Lovastatin