E2F1 and c-Myc in cell growth and death.
Cell cycle machinery controls not only cell growth but also cell survival and death. For example, overexpression of c-Myc or E2F1, which are involved in G1/S transition, causes apoptosis under certain conditions. Furthermore, endogenous E2F1 also participates in apoptosis, as evidenced by the defect of apoptosis in E2F1-deficient mice. Candidate molecules that mediate c-Myc- and E2F1-enhanced apoptosis include p14/p19ARF, ornithine decarboxylase and lactate dehydrogenase-A (for c-Myc) as well as p14/p19ARF, p73, Apaf-1 and caspase-3 (for E2F1). c-Myc also activates the CD95/Fas-FADD-mediated death signal. c-Myc and E2F1 inhibit NF-kappaB activities induced by TNFalpha or reactive oxygen species. Therefore, c-Myc and E2F1 regulate cell growth and death not only by inducing transcription but also by modulating signal transduction pathways.
Matsumura
Itaru
I
Department of Hematology/Oncology, Osaka University Graduate School of Medicine 2-2 Yamada-oka, Suita, Osaka 565-0871 Japan. matumura@bldon.med.osaka-u.ac.jp
Tanaka
Hirokazu
H
Kanakura
Yuzuru
Y
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D053477:Apoptotic Protease-Activating Factor 1; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins; D016923:Cell Death / Q000502:physiology; D002455:Cell Division / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology*; D019941:Cyclin-Dependent Kinase Inhibitor p16; D004268:DNA-Binding Proteins / Q000378:metabolism; D050684:E2F Transcription Factors; D050687:E2F1 Transcription Factor; D016147:Genes, Tumor Suppressor; D015801:Helminth Proteins / Q000378:metabolism; D051379:Mice; D009124:Muscle Proteins / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D025941:Protein Interaction Mapping; D011506:Proteins / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D016196:S Phase / Q000502:physiology; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*; D000072160:Tumor Protein p73; D025803:Tumor Suppressor Protein p14ARF / Q000378:metabolism; D025521:Tumor Suppressor Proteins; D019014:fas Receptor / Q000378:metabolism; D000096985:Calponins
D053477:Apoptotic Protease-Activating Factor 1; D053148:Caspase 3; D020169:Caspases; D018797:Cell Cycle Proteins; D019941:Cyclin-Dependent Kinase Inhibitor p16; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D050687:E2F1 Transcription Factor; D015801:Helminth Proteins; D009124:Muscle Proteins; D016328:NF-kappa B; D009687:Nuclear Proteins; D011506:Proteins; D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors; D000072160:Tumor Protein p73; D025803:Tumor Suppressor Protein p14ARF; D025521:Tumor Suppressor Proteins; D019014:fas Receptor; C506593:Apaf1 protein, mouse; C417743:Cdkn2a protein, mouse; C493754:E2f1 protein, mouse; C000606368:Trp73 protein, mouse; C118619:calponin homolog protein, Schistosoma japonicum; D000096985:Calponins; C505409:Casp3 protein, mouse