title: Novel coumarin derivatives of heterocyclic compounds as lipid-lowering agents.
abstract: Coumarin derivatives of different heterocycles (5,7a-i, 10 and 11) were designed based on cyclisation of 2-ethoxy-3-phenylpropanoic acid and 2-benzylmalonic acid as novel lipid-lowering agents and their preliminary in vivo screening indicates 7c has moderate triglyceride-lowering activity.
authors.affiliation: Discovery Chemistry, Dr. Reddy's Discovery Research, Bollarum Road, Miyapur, Hyderabad 500050, India. madhavangr@drreddys.com
authors.forename: Gurram R
authors.initials: GR
authors.lastname: Madhavan
authors.forename: Vadla
authors.initials: V
authors.lastname: Balraju
authors.forename: Bejugam
authors.initials: B
authors.lastname: Mallesham
authors.forename: Ranjan
authors.initials: R
authors.lastname: Chakrabarti
authors.forename: Vidya B
authors.initials: VB
authors.lastname: Lohray
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology*; D011345:Fenofibrate / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D051379:Mice; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D003374:Coumarins; D006571:Heterocyclic Compounds; D000960:Hypolipidemic Agents; D007202:Indicators and Reagents; D014280:Triglycerides; D011345:Fenofibrate