Intracellular Ca2+ signaling and human disease: the hunt begins with Huntington's.
Huntingtin, a protein altered by polyglutamine expansion in Huntington's disease (Httexp), forms a signaling complex with the InsP3R, an intracellular calcium channel, and Htt-associated protein 1A (HAP1A). The addition of Httexp increases the InsP3R sensitivity to InsP3, which subsequently makes neurons hyperresponsive to stimulation and presumably more prone to neurodegenerative processes.
Varshney
Anurag
A
Department of Pharmacology and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
Ehrlich
Barbara E
BE
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology
D002118:Calcium