title: Effect of oxyethylene moieties in hydrogenated castor oil on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with hydrogenated castor oil and soybean oil in rats.
abstract: Lipid emulsions with particle sizes of 190-270 nm were prepared with soybean oil (SO) and a series of hydrogenated castor oils (HCOs) with various oxyethylene numbers, and the effect of oxyethylene numbers of HCOs on the pharmacokinetics of menatetrenone incorporated into the lipid emulsions was studied in rats. Plasma half-life of menatetrenone after administration as the lipid emulsions prepared by HCO with 10 oxyethylene units (SO/HCO10) was similar to that after the administration as SO/egg yolk phosphatides (SO/EYP), but was shorter than that as the lipid emulsions prepared by HCOs with > 20 oxyethylene units (SO/HCO20, SO/HCO30, SO/HCO60, SOHC and SO/HCO100). Menatetrenone incorporated in SO/HCO10, SO/HCO20 and SO/HCO60 was not taken up by the blood cells in vitro, and the plasma level of menatetrenone incorporated in SO/HCO10 was similar to that of triglycerides, suggesting that menatetrenone was not released from the oil particles even after entering the circulation. Menatetrenone uptake by the liver for SO/HCO10 was similar to that for SO/EYP, while those for SO/HCO20, SO/HCO30, SO/HCO60 and SO/HCO100 was less than that for SO/EYP. These findings clearly demonstrate that 20 oxyethylene units in HCOs is the minimum requirement for the prolongation of the plasma circulation time of menatetrenone incorporated in SO/HCOs.
authors.affiliation: Department of Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan. ueda@kobepharma-u.ac.jp
authors.forename: Kumiko
authors.initials: K
authors.lastname: Ueda
authors.forename: Yuka
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Hiromi
authors.initials: H
authors.lastname: Noto
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Teshima
authors.forename: Chiharu
authors.initials: C
authors.lastname: Yamashita
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Sakaeda
authors.forename: Seigo
authors.initials: S
authors.lastname: Iwakawa
mesh_terms: D000818:Animals; D002368:Castor Oil / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004655:Emulsions; D006865:Hydrogenation; D008055:Lipids; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013024:Soybean Oil / Q000008:administration & dosage* / Q000737:chemistry; D024482:Vitamin K 2 / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics*; D014867:Water / Q000008:administration & dosage*
chemical_list: D004655:Emulsions; D008055:Lipids; D014867:Water; D024482:Vitamin K 2; C030814:menatetrenone; C023040:polyethoxylated castor oil; D013024:Soybean Oil; D002368:Castor Oil