title: Chemical genetics: adding to the developmental biology toolbox.
abstract: Recent advances in cell and molecular biology have generated important tools to probe developmental questions. In addition, new genetic model systems such as Danio rerio now make large-scale vertebrate early developmental mutant screens feasible. Nonetheless, some developmental questions remain difficult to study because of the need for finer temporal, spatial, or tuneable control of gene function within a developmental system. New uses for old teratogens as well as novel chemical modulators of development have begun to fill this void.
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.
authors.forename: Jing-Ruey J
authors.initials: JR
authors.lastname: Yeh
authors.forename: Craig M
authors.initials: CM
authors.lastname: Crews
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D015509:Developmental Biology; D004625:Embryo, Nonmammalian; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects*; D006801:Humans; D008954:Models, Biological; D008967:Molecular Biology; D009154:Mutation; D015398:Signal Transduction; D013723:Teratogens / Q000633:toxicity; D014714:Vertebrates / Q000196:embryology / Q000235:genetics; D015027:Zebrafish / Q000196:embryology / Q000235:genetics / Q000378:metabolism
chemical_list: D013723:Teratogens