[Effects of antiaggregants on concentration of plasma cytokines in patients with acute coronary syndrome].
We studied the levels of proinflammatory cytokines in the blood plasma of patients with acute coronary syndrome (ACS) when using antiaggregants differing in mechanisms of action. Cytokines were measured with application of solid phase enzyme immunoassay. The ACS patients were randomised into two groups. Group 1 received aspirin in a dose of 162.5 mg/day, group 2 received tienopyridines: tiklid 250 mg twice a day or plavix (clopidogrel) 75 mg/day. On admission to hospital, the patients had high levels of such proinflammatory cytokines as IL-1 beta, IL-8, TNF alpha which significantly lowered on treatment days 20 and 90. Aspirin reduced the cytokines levels in blood plasma more effectively than tienopyridines.
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D000208:Acute Disease; D001241:Aspirin / Q000627:therapeutic use*; D000077144:Clopidogrel; D003324:Coronary Artery Disease / Q000150:complications; D003328:Coronary Thrombosis / Q000097:blood* / Q000188:drug therapy* / Q000209:etiology; D016207:Cytokines / Q000097:blood* / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use*
D016207:Cytokines; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin