Methylated DNA as a possible screening marker for neoplastic disease in several body fluids.
Early detection appears to be one of the most important approaches to reducing mortality caused by neoplasia. Changes in DNA methylation have been recognized as one of the most common molecular alterations in human tumors. Due to the ubiquity of DNA methylation changes and the possibility to detect methylated DNA in several body fluids, this specifically altered DNA may serve as a potential new screening marker for neoplastic disease.
Müller
Hannes M
HM
Department of Obstetrics and Gynecology, Innsbruck University Hospital, Austria. Hannes.Mueller@uibk.ac.at
Widschwendter
Martin
M
D014408:Biomarkers, Tumor / Q000032:analysis; D001826:Body Fluids / Q000737:chemistry*; D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D008403:Mass Screening; D025202:Molecular Diagnostic Techniques; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm