Using stated preference modeling to forecast the effect of medication attributes on prescriptions of alcoholism medications.
OBJECTIVE
The objective of this study was to forecast physicians' preferred rate of prescriptions of alcoholism medications given different medications attributes (i.e., efficacy, side effects, compliance, price, mode of administration, method of action).


METHODS
Stated preference modeling was used. Data came from a survey of 1388 physicians specializing in addiction medication (65% response rate). Physicians were given four hypothetical scenarios, each in which they were asked to choose between prescribing one of two hypothetical alcoholism medications with given attributes or prescribing no medication.


RESULTS
Prescribing decisions were elastic with respect to the efficacy of the medication (1.35 and 1.65 using two efficacy measures). A 10% increase in the percentage of patients who would remain abstinent on the medication would lead to a 13.5% increase in the percentage of patients prescribed the medication. Prescribing decisions were inelastic with respect of nonserious side effects (-0.24), compliance (0.80), and price (-0.25). The market share of alcoholism medications with extremely favorable characteristics (i.e., 80% abstinence rate, a 95% no heavy drinking rate, a 10% side effect rate, a 80% compliance rate, and a price of US dollars 0.25) was predicted to be 53%, and 47% of the population would not be prescribed a medication to prevent alcoholism.


CONCLUSIONS
The market share of new medications to treat alcoholism among addiction specialists could surpass the low usage rates of existing medications if those medications have better attributes. However, prescription levels may not reach that expected for treatment of other diseases.
Mark
Tami L
TL
Medstat, Washington, DC 20008, USA. Tami.Mark@Medstat.com
Swait
Joffre
J
D000427:Alcohol Deterrents / Q000627:therapeutic use; D000437:Alcoholism / Q000188:drug therapy*; D003661:Decision Support Techniques; D004221:Disulfiram / Q000627:therapeutic use; D011307:Drug Prescriptions; D004363:Drug Utilization / Q000706:statistics & numerical data*; D005544:Forecasting / Q000379:methods*; D006801:Humans; D009271:Naltrexone / Q000627:therapeutic use; D010865:Pilot Projects; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires; D014481:United States
D000427:Alcohol Deterrents; D009271:Naltrexone; D004221:Disulfiram