Gene regulation in cancer gene therapy strategies.
Regulation of expression in gene therapy is considered to be a very desirable goal, preventing toxic effects and improving biological efficacy. A variety of systems have been reported in an ever widening range of applications, this paper describes these systems with specific reference to cancer gene therapy.
Scanlon
Ian
I
Cancer Research UK Centre for Cancer Therapeutics at the Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.
Lehouritis
Panos
P
Niculescu-Duvaz
Ion
I
Marais
Richard
R
Springer
Caroline J
CJ
D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000528:radiation effects*; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D009369:Neoplasms / Q000628:therapy