Chemokine induction by HIV-1: recruitment to the cause.
Immunomodulation frequently occurs during viral infections; the mechanisms of which are continually being defined at the cellular and tissue levels. Recently, a study of the effects of HIV-1 on dendritic cells (DCs) identified inflammatory chemokines as highly upregulated during HIV-1 infection and during viral Tat expression in monocyte-derived DCs. It is becoming increasingly clear that HIV-1 has evolved multiple strategies to ensure the maintenance of a local pool of susceptible cells for additional rounds of virus replication.
Reinhart
Todd A
TA
Department of Infectious Diseases and Microbiology, University of Pittsburgh, Graduate School of Public Health, 606 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA. reinhar@pitt.edu <reinhar@pitt.edu>
D000818:Animals; D018925:Chemokines / Q000096:biosynthesis*; D003713:Dendritic Cells / Q000276:immunology; D015658:HIV Infections / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity; D014779:Virus Replication
D018925:Chemokines