[Effects of combined stress on rabbit serum and gastroduodenal mucosa motilin and its mechanism].
OBJECTIVE
To study the effects of heat exposure and trauma stress on the level of motilin (MTL) in plasma and the distribution of MTL gastroduodenal mucosa and its mechanism in rabbits.


METHODS
The rabbits were randomly divided into four groups, control group, trauma group (23 centigrade degree), heat exposure group (38 centigrade degree) and heat exposure combined trauma group. The MTL was measured by radioimmunoassay (RIA). The rabbit model of heat exposure with trauma was established. The levels of the MTL were measured at 0, 0.5, 1, 1.5 and 2 hours during experiment.


RESULTS
In control group, the concentration of MTL was highest in gastric corpus, and then were gastric fundus, pylorus and Duodenal mucous membrane. The concentration of MTL was higher in plasma than that in tissues. After heat exposure and trauma, the concentration of MTL decreased in tissues and increased in plasma.


CONCLUSIONS
The concentration of MTL was different in different parts of gastroduodenal mucosa. The heat exposure and trauma stress may result in the converse changes of the level of MTL in plasma and tissues. The mechanism might be that the destroyed Mo cells released MTL and increasing level of bombesin stimulated by stress induced the release of MTL.
Chen
Guang-zhong
GZ
The Department of Heat Environmental Medicine, First Military Medical University, Guangzhou 510515, Guangdong, China.
Luo
Bing-de
BD
Zhai
Hui-min
HM
Wang
Hong-qin
HQ
Zou
Fei
F
D000818:Animals; D004386:Duodenum; D005753:Gastric Mucosa / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D009037:Motilin / Q000097:blood* / Q000378:metabolism*; D011817:Rabbits; D013312:Stress, Physiological
D009037:Motilin