The co-expression of VR1 and VRL-1 in the rat vagal sensory ganglia.
Immunohistochemistry for two nociceptive transducers, the vanilloid receptor 1 (VR1) and vanilloid receptor 1-like receptor (VRL-1), was performed on the vagal sensory ganglia. In the jugular ganglion, VR1-immunoreactive (IR) neurons were small to medium-sized (range 49.7-1,125.6 microm(2), mean+/-S.D. 407.7+/-219.7 microm(2)), whereas VRL-1-IR neurons were medium-sized to large (range 223.6-1,341.1 microm(2), mean+/-S.D. 584.3+/-253.5 microm(2)). In the nodose ganglion, VR1- and VRL-1-IR neurons were mostly small to medium-sized (VR1: range 148.5-1464.4 microm(2), mean+/-S.D. 554.3+/-207.4 microm(2); VRL-1: range 161.7-1166.2 microm(2), mean+/-S.D. 541.9+/-186.2 microm(2)). The double immunofluorescence method revealed that co-expression of VR1-immunoreactivity among VRL-1-IR neurons was more abundant in the nodose ganglion (63%) than in the jugular ganglion (4%). The present study suggests that co-expression of VR1 and VRL-1 may be more common in visceral sensory neurons than in somatic sensory neurons.
Ichikawa
H
H
Department of Oral Function and Anatomy, and Biodental Research Center, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8525, Japan. hiroichi@md.okayama-u.ac.jp
Sugimoto
T
T
D000818:Animals; D017950:Ganglia, Sensory / Q000737:chemistry / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011955:Receptors, Drug / Q000032:analysis / Q000096:biosynthesis*; D050916:TRPV Cation Channels; D014630:Vagus Nerve / Q000737:chemistry / Q000378:metabolism*
D011955:Receptors, Drug; D050916:TRPV Cation Channels; C494484:TRPV1 receptor