Third trimester glycemic profiles and fetal growth.
Diabetes is a common complication of pregnancy. Third trimester hyperglycemia has been associated in both gestational and pregestational diabetes with deviant fetal growth. Recent studies demonstrated that peak postprandial glucose levels in normal pregnancy are lower than previously thought. This finding could explain the lack of effectiveness reported by some investigators in achieving a rate of macrosomia similar to the general population. Among different possible blood glucose determinations, it appears that 1-hour postprandial as well as the overall mean blood glucose levels are the most closely correlated with fetal growth. It seems that a narrow window of glycemic levels is associated with optimal fetal growth because excessively tight glycemic control has been associated with increased incidence of small-for-gestational-age infants.
Leguizamón
Gustavo
G
Department of Obstetrics and Gynecology, High Risk Pregnancy Unit, Center of Medical Education and Clinical Research University, University of Buenos Aires, Galván 4102, Buenos Aires 1431, Argentina. gleguizamon@cemic.edu.ar
von Stecher
Francisco
F
D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D016640:Diabetes, Gestational / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D006801:Humans; D008991:Monitoring, Physiologic; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood / Q000502:physiology*; D011254:Pregnancy in Diabetics / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D013997:Time Factors; D016216:Ultrasonography, Prenatal
D001786:Blood Glucose