[Antioxidant action of oligomeric proanthocyanidins isolated from viburnum in liver lesions by carbon tetrachloride and prevention of the latter's toxicity].
The effect of a set of oligomeric anthocyanidins, isolated from viburnum, produced on the indices of lipid metabolism, lipid peroxidation (LPO) and on the hepatic antioxidant system in rats, who were subjected to the impact of carbon tetrachloride (CTC), was studied versus such effect exerted by preparations "Piknogenol" and "Legalon". The set of oligomeric anthocyanidins had a pronounced antitoxic and antioxidant action preventing the development of fat infiltration of the liver. The discussed preparation inhibited the processes of LPO, it normalized the level of antiradical hepatic activity and had a pronounced glutathione-saving effect, which is preconditioned by the biological activity of oligomeric anthocyanidins (traps for free radicals). The preparation can be used in prevention and treatment of toxic hepatic lesions.
Sprygin
V G
VG
Kushnerova
N F
NF
Rakhmanin
Iu A
IuA
D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage / Q000032:analysis* / Q000494:pharmacology*; D000975:Antioxidants / Q000008:administration & dosage / Q000032:analysis* / Q000494:pharmacology*; D002252:Carbon Tetrachloride Poisoning / Q000150:complications*; D005609:Free Radicals / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008107:Liver Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000032:analysis* / Q000494:pharmacology*; D044945:Proanthocyanidins; D051381:Rats; D017208:Rats, Wistar; D027925:Viburnum / Q000737:chemistry*
D000872:Anthocyanins; D000975:Antioxidants; D005609:Free Radicals; D010936:Plant Extracts; D044945:Proanthocyanidins; C013221:proanthocyanidin