title: Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity.
abstract: Prenylated flavonoids containing the resorcinol moiety were isolated as tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation. Among the 12 compounds isolated, kuraridin, kurarinone and norkurarinol showed stronger inhibitory potencies (IC 50 = 1.1, 1.3 and 2.1 microM, respectively) than that of kojic acid (IC 50 = 11.3 microM), a well known tyrosinase inhibitor. Substitution of a lavandulyl or hydroxylavandulyl group at the C-8 position and a methoxy or hydroxy group at the C-5 position are essential for the inhibitory effect.
authors.affiliation: College of Pharmacy, Yeungnam University, Kyongsan, Korea.
authors.forename: Jong Keun
authors.initials: JK
authors.lastname: Son
authors.forename: Ji Soo
authors.initials: JS
authors.lastname: Park
authors.forename: Jeong Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Youngsoo
authors.initials: Y
authors.lastname: Kim
authors.forename: See Ryun
authors.initials: SR
authors.lastname: Chung
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Lee
mesh_terms: D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D017368:Protein Prenylation; D011753:Pyrones / Q000494:pharmacology; D029909:Sophora
chemical_list: D005419:Flavonoids; D010455:Peptides; D010936:Plant Extracts; D011753:Pyrones; C011890:kojic acid; D014442:Monophenol Monooxygenase