Systemic lupus erythematosus and other autoimmune diseases from endogenous and exogenous agents: unifying theme of oxidative stress.
Extensive evidence supports oxidative stress (OS) via endogenous and exogenous agents as an important factor in induction of autoimmunity. OS arises from the immune system and other endogenous sources. The literature contains support for OS involvement of various drugs and other exogenous substances that produce the condition. Studies reveal prevention or amelioration by antioxidants.
Kovacic
Peter
P
Department of Chemistry, San Diego State University, San Diego, California 92182 USA. pkovacic@sundown.sdsu.edu
Jacintho
Jason D
JD
D000975:Antioxidants / Q000494:pharmacology; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D016877:Oxidants / Q000737:chemistry / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D015262:Xenobiotics / Q000008:administration & dosage
D000975:Antioxidants; D016877:Oxidants; D017382:Reactive Oxygen Species; D015262:Xenobiotics