Acetophenone derivatives from Acronychia pedunculata.
Chemical investigation on the stem and root bark of Acronychia pedunculata has resulted in the isolation of five new acetophenones, namely, acronyculatins A (1), B (2), C (3), D (4), and E (5). The structures of these metabolites were established on the basis of their 1D and 2D NMR spectroscopic and mass spectrometric data and by CD spectroscopy. The antioxidant and antityrosinase activities of these five metabolites and acrovestone (6) were evaluated. Among these compounds, 6 showed marginal antioxidant and antityrosinase activities.
Su
Chung-Ren
CR
Department of Chemistry, National Cheng Kung University, Tainan, 701, Taiwan, Republic of China.
Kuo
Ping-Chung
PC
Wang
Meei-Ling
ML
Liou
Meei-Jen
MJ
Damu
Amooru G
AG
Wu
Tian-Shung
TS
D000098:Acetophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D027821:Rutaceae / Q000737:chemistry*; D013624:Taiwan
D000098:Acetophenones; D000975:Antioxidants; D004791:Enzyme Inhibitors; C061305:acrovestone; D014442:Monophenol Monooxygenase