title: New building blocks for the assembly of sequence selective molecular zippers.
abstract: Synthetic H-bonded molecular zippers contain no sequence information that can be used to engineer the selective binding interactions characteristic of biopolymers; reversing the sense of the amide bonds in the two binding partners generates a new orthogonal recognition motif and the mutually complementary binding partners form complexes an order of magnitude more stable than the corresponding mismatch complexes.
authors.affiliation: Centre for Chemical Biology, Krebs Institute for Biomolecular Science, Department of Chemistry, University of Sheffield, Sheffield, UK S3 7HF.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Hunter
authors.forename: Philip S
authors.initials: PS
authors.lastname: Jones
authors.forename: Pascale M N
authors.initials: PM
authors.lastname: Tiger
authors.forename: Salvador
authors.initials: S
authors.lastname: Tomas
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001665:Binding Sites; D001704:Biopolymers / Q000737:chemistry*; D006860:Hydrogen Bonding; D046911:Macromolecular Substances; D015394:Molecular Structure; D015202:Protein Engineering / Q000379:methods*
chemical_list: D001704:Biopolymers; D046911:Macromolecular Substances