A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5.
Tanaka
M
M
Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Berul
C I
CI
Ishii
M
M
Jay
P Y
PY
Wakimoto
H
H
Douglas
P
P
Yamasaki
N
N
Kawamoto
T
T
Gehrmann
J
J
Maguire
C T
CT
Schinke
M
M
Seidman
C E
CE
Seidman
J G
JG
Kurachi
Y
Y
Izumo
S
S
D000200:Action Potentials; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000235:genetics* / Q000503:physiopathology; D004195:Disease Models, Animal; D004594:Electrophysiology; D006344:Heart Septal Defects, Atrial / Q000235:genetics* / Q000503:physiopathology; D006579:Heterozygote; D000072576:Homeobox Protein Nkx-2.5; D018398:Homeodomain Proteins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D008817:Mice, Mutant Strains; D032383:Myocytes, Cardiac / Q000378:metabolism; D018408:Patch-Clamp Techniques; D011188:Potassium / Q000378:metabolism; D017180:Tachycardia, Ventricular / Q000235:genetics / Q000503:physiopathology; D014157:Transcription Factors; D029867:Xenopus Proteins
D000072576:Homeobox Protein Nkx-2.5; D018398:Homeodomain Proteins; C095552:NKX2-5 protein, human; C484469:Nkx2-5 protein, mouse; D014157:Transcription Factors; D029867:Xenopus Proteins; D011188:Potassium