title: Racial differences in survival after diagnosis with primary malignant brain tumor.
abstract: BACKGROUND
  Previous studies have shown that the overall incidence of primary malignant brain tumor is greatest in Caucasians, although survival is better in African Americans. The objective of this study was to examine racial differences in survival after diagnosis with primary malignant brain tumor in a population-based sample of patients while adjusting for prognostic variables that differ by race.
  
  
  METHODS
  The authors analyzed 21,493 patients (20,493 Caucasians and 1000 African Americans) who were diagnosed with primary malignant brain tumors from 1973 to 1997 (with follow-up through 1999) from the population-based Surveillance, Epidemiology, and End Results (SEER) Program. Chi-square tests were used to determine statistical significance of prognostic variables and race (using two-sided P values). Kaplan-Meier and Cox proportional hazards models were used to assess survival differences by race.
  
  
  RESULTS
  The univariable model for race showed no survival difference by race. The multivariable model demonstrated that African American patients were at a 13% increased risk of death from any cause compared with Caucasian patients. The racial difference was explained further by an interaction between race and surgery type in which there was an increased risk of death for African American patients who underwent subtotal resections or surgery not otherwise specified compared with Caucasian patients who underwent the same procedures.
  
  
  CONCLUSIONS
  There was a significant difference in the risk of death due to any cause for Caucasian patients and African American patients who were diagnosed with first primary brain tumors.
authors.affiliation: Department of Internal Medicine, Division of Hematology/Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. jbsloan@med.wayne.edu
authors.forename: Jill S
authors.initials: JS
authors.lastname: Barnholtz-Sloan
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Sloan
authors.forename: Ann G
authors.initials: AG
authors.lastname: Schwartz
mesh_terms: D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000175:diagnosis / Q000208:ethnology / Q000401:mortality; D044383:Black People; D001932:Brain Neoplasms / Q000175:diagnosis / Q000208:ethnology* / Q000401:mortality*; D002423:Cause of Death; D016021:Epidemiologic Studies; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis / Q000208:ethnology / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D009837:Oligodendroglioma / Q000175:diagnosis / Q000208:ethnology / Q000401:mortality; D011379:Prognosis; D012307:Risk Factors; D018426:SEER Program; D015996:Survival Rate; D044465:White People; D001741:Black or African American