In vitro susceptibilities of seven Leptospira species to traditional and newer antibiotics.
Human leptospirosis is generally treated with penicillin or doxycycline. We studied the susceptibilities of 11 serovars (seven species) of Leptospira to 14 antibiotics. With the exception of chloramphenicol, all tested agents were at least as potent as penicillin and doxycycline, with the macrolide and ketolide drugs producing the lowest MICs (and minimal bactericidal concentrations).
Hospenthal
Duane R
DR
Infectious Disease Service, Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas, USA. Duane.Hospenthal@amedd.army.mil
Murray
Clinton K
CK
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D007201:Indicator Dilution Techniques; D007919:Leptospira / Q000187:drug effects*; D007922:Leptospirosis / Q000382:microbiology; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents