title: Transmission of HIV type 1 through blood transfusion from an antibody-negative/p24 antigen-negative donor.
abstract: Transmission of HIV through transfusion occurred in a 78-year-old male after receiving red blood cells from a 27-year-old woman, who was negative for HIV antibodies and p24 antigen at the time of donation, but seroconverted thereafter. Plasma viral load at donation was 2538 HIV RNA copies/ml. Phylogenetic analyses demonstrated that viruses from both patients clustered tightly together, belonged to subtype B clade, and had no primary drug resistance mutations. This case highlights the residual risk of HIV transmission from donors in the window period, and supports the implementation of nucleic acid testing in blood banks.
authors.affiliation: Department of Infectious Diseases, Instituto de Salud Carlos III, 28029 Madrid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Toro
authors.forename: Berta
authors.initials: B
authors.lastname: Rodés
authors.forename: Félix
authors.initials: F
authors.lastname: Colino
authors.forename: Maria
authors.initials: M
authors.lastname: del Valle Flores
authors.forename: Eva
authors.initials: E
authors.lastname: Poveda
authors.forename: Carmen
authors.initials: C
authors.lastname: de Mendoza
authors.forename: Maria Jesús
authors.initials: MJ
authors.lastname: Téllez
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
mesh_terms: D000328:Adult; D000368:Aged; D001782:Blood Donors; D001803:Blood Transfusion; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D016655:HIV Core Protein p24 / Q000097:blood; D015658:HIV Infections / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood*
chemical_list: D015483:HIV Antibodies; D016655:HIV Core Protein p24; D012367:RNA, Viral