Powder dispensing robot for sample preparation.
An automated powder dispensing station capable of transferring milligram quantities (1-100 mg) of powder for sample preparation was developed and integrated into a commercial robotic workstation (Zymark Prelude). The system's performance was optimized with respect to vacuum flow rate and powder transfer tube cross sectional area, and shown to possess excellent powder dispensing accuracy (RSD = < or = 0.1% for target weights < or = 15 mg) and precision (RSD = 3.43%) for a vanillin sample. Using the commercial features of the Zymark Prelude workstation (liquid handling, weighing, and vortexing/mixing) and the custom powder dispensing station, multiple sets of analytical calibration standards were prepared and subsequently analyzed by FIA in order to assess the system's robustness for sample preparation.
Fermier
Adam M
AM
Johnson & Johnson Pharmaceutical Research and Development, 1000 Route 202, Box 300, Raritan, NJ 08869, USA. afermier@prdus.jnj.com
Troisi
John
J
Heritage
Erin C
EC
Drexel
Melissa A
MA
Gallea
Pablo
P
Swinney
Kelly A
KA
D004345:Drug Industry; D011208:Powders; D012371:Robotics; D013048:Specimen Handling
D011208:Powders