[Studies on the toxic effects of magnetic targeting adriamycin-carboxymethyldextran magnetic nanoparticles].
In this paper, adriamycin-carboxymethyldextran magnetic nanoparticles (ADR-CMD MNPs) were prepared. After i.v. administration in mice, acute toxicity, cumulative toxicity and the distribution profiles of heart were studied both for free adriamycin(ADR) and ADR-CMD MNPs. The results showed conjugation with CMD MNPs, the acute toxicity of ADR was decreased significantly, the LD50 value of ADR-CMD MNPs was 5.06 times as high as that of the free ADR. Altogether, the cumulative toxicity of conjugate MNPs is significantly decreased as expressed by the mortality, the loss for both weight and leucocyte after repeated injection. Tissue distribution studies show the reduced cardiac uptake of ADR after i.v. which possibly contributes to minimizing the cardiotoxic effect of ADR.
Shi
Keyu
K
State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, College of Chemistry, Nankai University, Tianjin 300071.
Li
Chaoxing
C
He
Binglin
B
D000818:Animals; D003911:Dextrans; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005260:Female; D007275:Injections, Intravenous; D008280:Magnetics; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D014018:Tissue Distribution
D003911:Dextrans; D004337:Drug Carriers; D004317:Doxorubicin; C014392:carboxymethyl dextran