Misclassification in a matched case-control study with variable matching ratio: application to a study of c-erbB-2 overexpression and breast cancer.
We provide a simple analytic correction for risk factor misclassification in a matched case-control study with variable numbers of controls per case. The method is an extension of existing methodology, and involves estimating the corrected proportions of controls and cases in risk factor categories within each matched set. These estimates are then used to calculate the Mantel-Haenszel odds ratio estimate corrected for misclassification. A simulation-based interval estimate is developed. An example is given from a study of risk factors for progression of benign breast disease to breast cancer, in which the risk factor is a biological marker measured with poor sensitivity.
Duffy
Stephen W
SW
Department of Epidemiology, Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. duffy@cancer.org.uk
Rohan
Thomas E
TE
Kandel
Rita
R
Prevost
Teresa C
TC
Rice
Kenneth
K
Myles
Jonathan P
JP
D001943:Breast Neoplasms / Q000145:classification / Q000235:genetics; D016022:Case-Control Studies; D003198:Computer Simulation; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018734:Genes, erbB-2; D005819:Genetic Markers; D006801:Humans; D008390:Markov Chains; D009010:Monte Carlo Method; D016017:Odds Ratio; D012307:Risk Factors
D005819:Genetic Markers