title: Comparisons of glucose and lipid metabolism in rats fed diacylglycerol and triacylglycerol oils.
abstract: The effects of dietary 1,3-diacylglycerol-rich oil (DG oil) on biochemical findings related to glucose and lipid metabolisms were investigated in comparison with triacylglycerol oil (TG oil) in normal rats. Young (7 wk-old) and old (8 mo-old) rats were fed a synthetic diet containing 10% (by weight) DC or TG oil for 1, 4, 8, or 12 wk. The body weights, epididymal and perirenal adipose tissue weights, and feed efficiency were not significantly different in the dietary oil groups during any feeding period. The plasma and liver triacylglycerol concentrations were not different in the dietary groups, except that the plasma triacylglycerol concentrations were rather lower only in the portal vein of rats fed DG oil. The plasma glucose and free fatty acid concentrations were significantly higher in rats fed DG oil as compared to TG oil. In the old rats fed DG oil for 8 wk, the fasted plasma glucose and insulin concentrations were elevated and glucose intolerance was observed. The insulin receptor expression was not different due to dietary oil, but was markedly reduced with aging. Thus, the anti-obesity and lipid-lowering effects of dietary DG oil were not found. Moreover, it appeared that the glucose intolerance might be induced by dietary DG oil, particularly in the old rats.
authors.affiliation: Faculty of Human and Culture Studies, Tezukayama Gakuin University, 4-2-2 Harumidai, Sakai, Osaka 590-0113, Japan.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Tomoe
authors.initials: T
authors.lastname: Kimura
authors.forename: Hitomi
authors.initials: H
authors.lastname: Fukuda
authors.forename: Nobuko
authors.initials: N
authors.lastname: Iritani
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004075:Diglycerides / Q000008:administration & dosage*; D005215:Fasting; D005227:Fatty Acids / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005947:Glucose / Q000008:administration & dosage; D007328:Insulin / Q000097:blood; D007657:Ketone Bodies / Q000097:blood; D007700:Kinetics; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000737:chemistry; D008297:Male; D011169:Portal Vein; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D011972:Receptor, Insulin / Q000235:genetics; D014280:Triglycerides / Q000008:administration & dosage* / Q000097:blood; D014682:Vena Cava, Inferior
chemical_list: D001786:Blood Glucose; D004042:Dietary Fats, Unsaturated; D004075:Diglycerides; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007657:Ketone Bodies; D008055:Lipids; D012333:RNA, Messenger; D014280:Triglycerides; D011972:Receptor, Insulin; D005947:Glucose