title: Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments.
abstract: Platelets are highly reactive components of the circulatory system with well-documented hemostatic function. Recent studies extend platelet function to modulation of local inflammatory events through the release of chemokines, cytokines, and a number of immunomodulatory ligands, including CD154. We hypothesized that platelet-derived CD154 modulates adaptive immunity. The data reported herein demonstrate that platelets, via CD154, induce dendritic cell maturation, B cell isotype switching, and augment CD8(+) T cell responses both in vitro and in vivo. Platelet transfusion studies demonstrate that platelet-derived CD154 alone is sufficient to induce isotype switching and augment T lymphocyte function during viral infection, leading to enhanced protection against viral rechallenge. Additionally, depletion of platelets in normal mice results in decreased antigen-specific antibody production.
authors.affiliation: The University of Iowa, Department of Urology, Iowa City, IA 52242, USA.
authors.forename: Bennett D
authors.initials: BD
authors.lastname: Elzey
authors.forename: Jun
authors.initials: J
authors.lastname: Tian
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Jensen
authors.forename: Axel K
authors.initials: AK
authors.lastname: Swanson
authors.forename: Jason R
authors.initials: JR
authors.lastname: Lees
authors.forename: Steven R
authors.initials: SR
authors.lastname: Lentz
authors.forename: Colleen S
authors.initials: CS
authors.lastname: Stein
authors.forename: Bernhard
authors.initials: B
authors.lastname: Nieswandt
authors.forename: Yiqiang
authors.initials: Y
authors.lastname: Wang
authors.forename: Beverly L
authors.initials: BL
authors.lastname: Davidson
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Ratliff
mesh_terms: D000222:Adaptation, Physiological; D000256:Adenoviridae / Q000276:immunology; D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D023201:CD40 Ligand / Q000097:blood / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D007113:Immunity, Innate; D051379:Mice; D008810:Mice, Inbred C57BL; D014777:Virus Diseases / Q000276:immunology
chemical_list: D023201:CD40 Ligand