title: [Potential pro-thrombotic effects of cyclooxygenase-2. inhibitors Two cases pf myocardial infarction].
abstract: Type 2 cyclo-oxygenase inhibitors are new anti-inflammatory drugs with better gastrointestinal tolerance than traditional non-steroidal anti-inflammatory drugs. They have no platelet anti-aggregant effects and there is still some discussion as to whether this new therapeutic class has any pro-thrombotic effects. The authors report two cases of myocardial infarction in patients considered to be at low risk treated by type 2 cyclo-oxygenase inhibitors.
authors.affiliation: Service de cardiologie CHG Louis Pasteur 28018 Chartres Le Coudray.
authors.forename: C
authors.initials: C
authors.lastname: Thuaire
authors.forename: L
authors.initials: L
authors.lastname: Mankoubi
authors.forename: G
authors.initials: G
authors.lastname: Rangé
authors.forename: L
authors.initials: L
authors.lastname: Roussel
authors.forename: H
authors.initials: H
authors.lastname: Belfaqih
authors.forename: L
authors.initials: L
authors.lastname: el Khayef
authors.forename: A
authors.initials: A
authors.lastname: Belghit
authors.forename: M
authors.initials: M
authors.lastname: Charaf
authors.forename: F
authors.initials: F
authors.lastname: Albert
mesh_terms: D000328:Adult; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D009154:Mutation; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000235:genetics; D011451:Prostaglandin-Endoperoxide Synthases; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D016896:Treatment Outcome; D016277:Ventricular Function, Left
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; C095381:factor V Leiden; D005165:Factor V; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D010959:Tissue Plasminogen Activator