Inhibition of experimental gastric lesion and inflammation by Phyllanthus amarus extract.
Methanolic extract of Phyllanthus amarus Shum & Thonn (Euphorbiaceae) 50, 200, and 1000 mg/kg body weight significantly inhibited gastric lesions, induced by intragastric administration of absolute ethanol (8 ml/kg). Mortality, increased stomach weight, ulcer index, and intraluminal bleeding were reduced significantly by Phyllanthus amarus. Biochemical analysis indicated that reduced glutathione (GSH) of gastric mucosa produced by ethanol administration was significantly elevated by treatment with Phyllanthus amarus extract. Aqueous and methanol extracts of Phyllanthus amarus produced an inhibition of rat paw edema up to 42% compared to control in 3h and continued up to 8h. Anti-oxidant activity of the extract as well as presence of tannins in the extract may be responsible for these observed activities.
Raphael
K Regi
KR
Amala Cancer Research Centre, Thrissur, Kerala 680 553, India.
Kuttan
Ramadasan
R
D000818:Animals; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy*; D000431:Ethanol; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D000432:Methanol; D029803:Phyllanthus / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014456:Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D014867:Water
D010936:Plant Extracts; D014867:Water; D000431:Ethanol; D002351:Carrageenan; D000432:Methanol