title: Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats.
abstract: OBJECTIVE
  To investigate the effect of tetramethylpyrazine on hepatic/renal ischemia and reperfusion injury in rats.
  
  
  METHODS
  Hepatic/renal function, histopathological changes, and hepatic/renal P-selectin expression were studied with biochemical measurement and immunohistochemistry in hepatic/renal ischemia and reperfusion injury in rat models.
  
  
  RESULTS
  Hepatic/renal insufficiency and histopathological damage were much less in the tetramethylpyrazine-treated group than those in the saline-treated groups. Hepatic/renal P-selectin expression was down regulated in the tetramethylpyrazine-treated group.
  
  
  CONCLUSIONS
  P-selectin might mediate neutrophil infiltration and contribute to hepatic/renal ischemia and reperfusion injury. Tetramethylpyrazine might prevent hepatic/renal damage induced by ischemia and reperfusion injury through inhibition of P-selectin.
authors.affiliation: Department of Gastroenterology, Shanghai Sixth People's Hospital, Shanghai Jiao-Tong University, Shanghai 200233, China. cqinqin@fm365.com
authors.forename: Jin-Lian
authors.initials: JL
authors.lastname: Chen
authors.forename: Tong
authors.initials: T
authors.lastname: Zhou
authors.forename: Wei-Xiong
authors.initials: WX
authors.lastname: Chen
authors.forename: Jin-Shui
authors.initials: JS
authors.lastname: Zhu
authors.forename: Ni-Wei
authors.initials: NW
authors.lastname: Chen
authors.forename: Ming-Jun
authors.initials: MJ
authors.lastname: Zhang
authors.forename: Yun-Lin
authors.initials: YL
authors.lastname: Wu
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D016166:Free Radical Scavengers / Q000494:pharmacology*; D007668:Kidney / Q000473:pathology / Q000502:physiology; D008099:Liver / Q000473:pathology / Q000502:physiology; D008297:Male; D019007:P-Selectin / Q000378:metabolism*; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D016166:Free Radical Scavengers; D019007:P-Selectin; D011719:Pyrazines; C017953:tetramethylpyrazine