title: Parasitological and morphological findings in porcine isosporosis after treatment with symmetrical triazintriones.
abstract: Neonatal porcine isosporosis is known to cause serious economic losses in piglet farms by causing severe enteritis with dehydration, weight loss and reduced development in the affected animals, predominantly during the first weeks of life. In the present study, piglets experimentally infected with Isospora suis were treated with Bay Vi 9143, a symmetrical triazintrione, at different days post-infection. As shown by clinical and pathological examinations, Bay Vi 9143 is effective against the asexual and sexual stages of I. suis at all selected treatment times. However, the therapeutic use at an early stage of asexual multiplication is most effective before the onset of clinical symptoms.
authors.affiliation: BHC-PH-P-Toxicologic Pathology, Pharma Research Center, Bayer AG, 42096 Wuppertal, Germany. ute.bach.ub@bayer-ag.de
authors.forename: Ute
authors.initials: U
authors.lastname: Bach
authors.forename: Victoria
authors.initials: V
authors.lastname: Kalthoff
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Mundt
authors.forename: Andreas
authors.initials: A
authors.lastname: Popp
authors.forename: Matthias
authors.initials: M
authors.lastname: Rinke
authors.forename: Arwid
authors.initials: A
authors.lastname: Daugschies
authors.forename: Bernhard
authors.initials: B
authors.lastname: Lüttge
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007421:Intestine, Small / Q000469:parasitology / Q000473:pathology; D007549:Isospora / Q000187:drug effects*; D021865:Isosporiasis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008854:Microscopy, Electron; D013553:Swine Diseases / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology
chemical_list: D000981:Antiprotozoal Agents