Presence of a bone marrow stromal cell line with myoid differentiation in reactive plasmacytosis and plasma cell myeloma.
The presence of myoid cells (MCs) - stromal cells with myogenic differentiation - in human bone marrow (BM) has been observed during hematopoiesis in embryonic life, whereas during adult life, it is strictly related to various pathologic conditions. The aim of this study was to examine the presence, distribution and quantitation of cells in the stroma of the BM expressing alpha-smooth muscle actin (alpha-SMA) in reactive BM plasmacytosis and plasma cell myeloma. For this reason, a series of 10 trephine BM biopsies from patients with plasma cell myeloma and 10 specimens from healthy controls with reactive plasmacytosis were examined for the presence of stromal cells with myoid differentiation, using a monoclonal antibody recognizing alpha-SMA. Our results suggest that the incidence of MCs and subsequent fibrosis rises in plasma cell myeloma and in a lesser degree in the BM stroma of individuals with reactive plasmacytosis.
Papadopoulos
N
N
Department of Histology-Embryology, Democritus University of Thrace, Greece. npapad@med.duth.gr
Kotini
A
A
Skaphida
P
P
Jivannakis
T
T
Cheva
A
A
Tamiolakis
D
D
D000199:Actins / Q000032:analysis; D015415:Biomarkers; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D001856:Bone Marrow Examination; D002454:Cell Differentiation; D006410:Hematopoiesis; D006801:Humans; D009101:Multiple Myeloma / Q000473:pathology*; D009124:Muscle Proteins / Q000032:analysis; D009132:Muscles / Q000473:pathology*; D055728:Primary Myelofibrosis / Q000473:pathology*; D011379:Prognosis; D019310:Pseudolymphoma / Q000473:pathology*; D017154:Stromal Cells / Q000737:chemistry / Q000473:pathology*
D000199:Actins; D015415:Biomarkers; D009124:Muscle Proteins