title: Anti-obesity effects of a mixture of thiamin, arginine, caffeine, and citric acid in non-insulin dependent diabetic KK mice.
abstract: Anti-obesity effects of a mixture of thiamin, arginine, caffeine, and citric acid (TACC) were investigated in non-insulin dependent diabetic KK mice. Feeding of either arginine or caffeine significantly suppressed an increase in hepatic lipid contents in fasted-refed KK mice. In addition, each component admixed with a low-calorie diet effectively reduced adipose tissue weight in KK mice previously fed a high-calorie diet. The decrease in adipose tissue weight was greater with a mixture of arginine and caffeine, and much greater with TACC than with arginine or caffeine alone. Moreover, plasma insulin concentration was significantly lower in mice fed TACC than in control mice. The anti-obesity effects of TACC were also shown when it was supplemented with a tea beverage. Adipose tissue weight, hepatic triglyceride contents, and plasma insulin concentration were significantly lower in mice given TACC-supplemented tea than in control mice. These results suggest that TACC is effective in reducing adipose tissue mass as well as improving disorders in lipid metabolism.
authors.affiliation: Research and Development Section, Takeda Food Products Ltd., 3-20 Imoji, Itami 664-0011, Japan. k_muroyama@mti.biglobe.ne.jp
authors.forename: Koutarou
authors.initials: K
authors.lastname: Muroyama
authors.forename: Shinji
authors.initials: S
authors.lastname: Murosaki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Odaka
authors.forename: Hee Chung
authors.initials: HC
authors.lastname: Chung
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Miyoshi
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage*; D001120:Arginine / Q000008:administration & dosage*; D002110:Caffeine / Q000008:administration & dosage*; D019343:Citric Acid / Q000008:administration & dosage*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004032:Diet; D019587:Dietary Supplements; D002149:Energy Intake; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000096:biosynthesis; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013662:Tea; D013831:Thiamine / Q000008:administration & dosage*; D014280:Triglycerides / Q000032:analysis
chemical_list: D019440:Anti-Obesity Agents; D007328:Insulin; D008055:Lipids; D013662:Tea; D014280:Triglycerides; D019343:Citric Acid; D002110:Caffeine; D001120:Arginine; D013831:Thiamine