title: Intracranial sinus thrombosis in a patient with Crohn disease and factor V Leiden mutation.
abstract: There is a well-known risk of thrombosis in patients with inflammatory bowel disease. Documented cases of intracranial sinus thrombosis in this setting are rare. We present the case of a 30-year-old man with Crohn disease who spontaneously developed a superior sagittal sinus thrombosis and bifrontal infarcts that resulted in death. The patient was heterozygous for factor V Leiden mutation. The literature was searched to assess the frequency of cerebral venous infarcts in inflammatory bowel disease and the role that factor V Leiden plays in thrombosis in such patients.
authors.affiliation: Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Maag
authors.forename: Richard A
authors.initials: RA
authors.lastname: Prayson
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000150:complications* / Q000235:genetics; D005165:Factor V / Q000235:genetics* / Q000502:physiology; D017809:Fatal Outcome; D006580:Genetic Carrier Screening; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D017354:Point Mutation; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis* / Q000209:etiology* / Q000235:genetics
chemical_list: C095381:factor V Leiden; D005165:Factor V