Getting (chromosomes) loaded--a new role for timeless.
A recent study in C. elegans reveals an unanticipated link between sister chromatid cohesion and the TIM-1 protein, a homolog of the Drosophila circadian rhythm protein TIMELESS. The phenotypes of tim-1 mutants suggest that cohesin subunits load onto chromosomes in a stepwise manner. Whether TIM-1 is also involved in circadian rhythms is discussed.
Golden
Andy
A
Laboratory of Biochemistry and Genetics, NIDDK, NIH, Bethesda, MD 20892, USA.
Cohen-Fix
Orna
O
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000502:physiology*; D002842:Chromatids / Q000502:physiology; D002875:Chromosomes / Q000502:physiology*; D002940:Circadian Rhythm; D004330:Drosophila; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D008540:Meiosis
D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins