Antibacterial coumarins from Angelica gigas roots.
Systematic fractionation of Angelica gigas roots led to the isolation of linear furano(pyrano)coumarins such as bergapten (1), decursinol angelate (2), decursin (3), nodakenetin (4) and nodakenin (5). The antibacterial activities of those compounds against pathogenic bacteria were investigated. Among the compounds tested, decursinol angelate (2) and decursin (3) exhibited significant antibacterial activity against Bacillus subtilis with the minimum inhibitory concentrations (MICs) of 50 and 12.5 microg/mL, respectively.
Lee
Sanghyun
S
Natural Products Research Institute, Seoul National University, Seoul 110-460, Korea.
Shin
Dong-Sun
DS
Kim
Ju Sun
JS
Oh
Ki-Bong
KB
Kang
Sam Sik
SS
D029969:Angelica / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
D000900:Anti-Bacterial Agents; D003374:Coumarins; D010936:Plant Extracts