Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin.
Unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin (DDPT) were prepared and tested for antitumor activity. The esters showed increased in vivo antitumor activity despite the lower in vitro activity than DDPT. Especially, the ester (DFE12) of all-cis-11,14-eicosadienoic acid was much better (IR, 83%) than VP-16 (IR, 60%) without loss of body weight. Unsaturated fatty acids could be evaluated to be good carrier vehicles of DDPT.
You
Young-Jae
YJ
College of Pharmacy, Chungnam National University, Taejon 305-764, South Korea.
Kim
Yong
Y
Nam
Nguyen-Hai
NH
Ahn
Byung-Zun
BZ
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects; D004337:Drug Carriers; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal; D004952:Esters / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*; D051379:Mice; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D004952:Esters; D005231:Fatty Acids, Unsaturated; C014451:deoxypodophyllotoxin; D011034:Podophyllotoxin