[Biological effects of collagen I and IV peptides].
Various biological events, such as cell differentiation, cell migration or gene expression, are controlled by cell-cell interactions or by cytokines, as well as by interactions between cells and extracellular matrix. The regulation of these events involves a directed and limited proteolysis of matrix macromolecules, that induces the release of proteic domains and peptides exhibiting biological activities. In this review, we summarise several data from our laboratory showing that peptides from type I and type IV collagens play an important role in the control of inflammation and tumor progression. Type I collagen peptides stimulate respiratory burst, granule exocytosis and cytokine secretion by human leukocytes (polymorphonuclear neutrophils or monocytes) for the detersion of inflammatory sites and then for the chemoattraction of various cell types needed for wound healing. A peptide of the NC1 domain of the alpha 3(IV) collagen chain prevents leukocyte activation. In addition, this peptide is also capable of limiting tumor progression by downregulating in vitro and in vivo invasive properties of melanoma cells.
Pasco
Sylvie
S
Laboratoire de Biochimie Médicale et Biologie Moléculaire, CNRS FRE 2534, IFR 53, UFR de Médecine, 51 rue Cognacq-Jay, 51095, Reims, France.
Ramont
Laurent
L
Maquart
François-Xavier
FX
Monboisse
Jean-Claude
JC
D024042:Collagen Type I / Q000494:pharmacology*; D024141:Collagen Type IV / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000502:physiology; D005089:Exocytosis / Q000187:drug effects; D006801:Humans; D008545:Melanoma / Q000473:pathology; D009000:Monocytes / Q000187:drug effects / Q000502:physiology; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D010455:Peptides / Q000494:pharmacology*; D016897:Respiratory Burst / Q000187:drug effects
D024042:Collagen Type I; D024141:Collagen Type IV; D016207:Cytokines; D010455:Peptides