[Genetic susceptibility to diabetes and hypertension].
Both type 2 diabetes and hypertension are multifactorial diseases. Several lines of evidence suggested that common genetic factors contribute to both conditions. Genes responsible for obesity and insulin resistance are candidates for common genetic factors. Among candidate genes are genes encoding glycogen synthase, beta 3-adrenergic receptor, glycogen-associated regulatory subunit of protein phosphatase-1, peroxisome proliferator--activated receptor-gamma (PPAR gamma), leptin and adiponectin. In addition, recent genome scans mapped loci linked to type 2 diabetes, hypertension and/or metabolic syndrome. Identification of genes responsible for both type 2 diabetes and hypertension will increase our understanding of molecular mechanisms of these conditions and facilitate the development of effective methods for prevention and intervention of diabetes and hypertension as well as metabolic syndrome.
Ikegami
Hiroshi
H
Department of Geriatric Medicine, Osaka University Graduate School of Medicine.
Ogihara
Toshio
T
D052242:Adiponectin; D000818:Animals; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000235:genetics*; D006006:Glycogen Synthase / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics*; D007333:Insulin Resistance / Q000235:genetics; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin / Q000235:genetics; D009765:Obesity / Q000235:genetics; D011506:Proteins / Q000235:genetics; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D011506:Proteins; D022702:Receptors, Adrenergic, beta-3; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D006006:Glycogen Synthase