[Research advances on inhibitor of apoptosis, survivin].
Survivin, a novel inhibitor of apoptosis, expressing in a cell cycle-dependent manner,regulates the G(2)/M phase of the cell cycle by associating with mitotic spindle microtubules; it directly inhibits caspase-3 and caspase-7activity. During tumorigenesis, survivin expression is inversely correlated with apoptosis and is positively correlated with proliferation and angiogenesis. Survivin expression up-regulation predicts short survival and poor prognosis in human cancers. Survivin targeting antisense nucleotide and survivin mutants induce apoptosis, reduce tumor growth potential, and sensitize tumor cells to chemotherapeutic drugs and X-irradiation in vitro and in vivo. These results suggest that survivin may has the potential function as a new target for the diagnosis and treatment of cancer.
Yang
Jing
J
Pathology Institute, Southwest Hospital, The Third Military Medical University, Chongqing, 400038, PR China. yangjing16@yahoo.com
Liu
Feng-Xuan
FX
Yan
Xiao-Chu
XC
D000818:Animals; D017209:Apoptosis; D002455:Cell Division; D005786:Gene Expression Regulation; D019254:Genes, bcl-2; D016259:Genes, myc; D016158:Genes, p53 / Q000502:physiology; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009363:Neoplasm Proteins; D009369:Neoplasms / Q000737:chemistry / Q000473:pathology / Q000628:therapy; D000077022:Survivin
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin