title: Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted beta-turn bicyclic dipeptide mimetics.
abstract: Novel constrained beta-turn dipeptide mimetics, 8-phenyl thiaindolizidinone amino acids 3, have been synthesized stereoselectively and incorporated into Leu-enkephalin peptides as a replacement of dipeptide Gly3-Phe4 to afford four individual isomers of Leu-enkephalin analogues 6.
authors.affiliation: Department of Chemistry, University of Arizona, 1306 E. University Blvd., Tucson, AZ 85721, USA.
authors.forename: Chiyi
authors.initials: C
authors.lastname: Xiong
authors.forename: Junyi
authors.initials: J
authors.lastname: Zhang
authors.forename: Peg
authors.initials: P
authors.lastname: Davis
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Jinfa
authors.initials: J
authors.lastname: Ying
authors.forename: Frank
authors.initials: F
authors.lastname: Porreca
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Hruby
mesh_terms: D019943:Amino Acid Substitution; D004151:Dipeptides / Q000138:chemical synthesis; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D018716:Molecular Mimicry; D017433:Protein Structure, Secondary; D013237:Stereoisomerism
chemical_list: D004151:Dipeptides; D004743:Enkephalin, Leucine