Constituents from the stems of Aristolochia manshuriensis.
In a continuing search for bioactive compounds from Aristolochia species, 28 compounds, including three new constituents, demethylaristofolin E (1), aristomanoside (2), and dehydrooxoperezinone (3), were isolated from an extract of the stems of Aristolochia manshuriensis. The structures of these compounds were established by extensive 1D and 2D NMR spectral studies. Among these compounds, dehydrooxoperezinone (3) was found to inhibit the replication of HIV, with an EC(50) value of 17.5 microg/mL and a therapeutic index of 1.43.
Wu
Pei-Lin
PL
Department of Chemistry, National Cheng Kung University, Tainan, 701, Taiwan, Republic of China.
Su
Gwo-Ching
GC
Wu
Tian-Shung
TS
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D030022:Aristolochia / Q000737:chemistry*; D004298:Dopamine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan
D019380:Anti-HIV Agents; D005663:Furans; D005960:Glucosides; D009285:Naphthoquinones; D010616:Phenanthrenes; C480060:aristomanoside; C480061:dehydrooxoperezinone; C480059:demethylaristofolin; D004298:Dopamine