[Clinical observation on the efficacy of ivermectin in the treatment of intestinal nematode infections].
OBJECTIVE
To observe the efficacy and side effects of ivermectin in the treatment of intestinal nematode infections.


METHODS
A single dose of ivermectin 0.1, 0.2, 0.2 and 0.2 mg/kg was orally administered to cases with infection of Ascaris, hookworm, Trichuris and Enterobius respectively. A single dose of albendazole 400 mg was used as control.


RESULTS
The egg negative conversion rates of ivermectin and albendazole were both 100% (34/34) for Ascaris infection, 17.6% (6/34) and 76.5% (26/34) respectively for hookworm infection, 67.6% (23/34) and 47.1% (16/34) respectively for Trichuris infection, 58.8% (20/34) and 100% (34/34) respectively for Enterobius infection. The worm discharge reached a peak in 1-2 days after treatment. The side effect of ivermectin was mild and transient showing no adverse effect on blood picture, liver function, renal function or ECG.


CONCLUSIONS
Ivermectin shows similar effect on Ascaris with albendazole, better effect on Trichuris and poorer effect on hookworm and Enterobius than albendazole.
Wen
Li-yong
LY
Institute of Parasitic Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013.
Li
Si-wen
SW
Wu
Ling-juan
LJ
Yang
Ji-shun
JS
Yan
Xiao-lan
XL
Yang
Ming-jin
MJ
Lou
Lei-jun
LJ
Zhan
Fu-chu
FC
Wang
Xu-yang
XY
Li
Tu-rong
TR
Shao
Jian-qiang
JQ
Zheng
Jin-chun
JC
Fu
Mei-hua
MH
D000293:Adolescent; D000328:Adult; D000368:Aged; D015766:Albendazole / Q000627:therapeutic use; D000969:Antinematodal Agents / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy*; D007559:Ivermectin / Q000627:therapeutic use*; D008875:Middle Aged; D009349:Nematode Infections / Q000188:drug therapy*; D016896:Treatment Outcome
D000969:Antinematodal Agents; D007559:Ivermectin; D015766:Albendazole