Synthetic metallo-porphyrins and selection criteria for PDT.
The aim of this paper is to analyse the some aspects about the main selection criteria of some metallo-porphyrins for PDT; purity, solubility, singlet oxygen generation and photostability. Also, some clinical applications of some porphyrins are evaluated. The PDT effect of some metallo-porphyrins on Murine Lymphoma EL-4 cells (as experimental model for photodynamic therapy studies), on Herpes Simplex Virus, on human brain cells, in ophthalmology, are discussed in this review.
Rodica-Mariana
Ion
I
Institute for Chemical Research-Icechim, Chemical Analysis Department, Splaiul Independentei 202, Bucharest-77208, Romania. irma@pcnet.ro
D000818:Animals; D003196:Computer Graphics; D006561:Herpes Simplex / Q000628:therapy; D006801:Humans; D016399:Lymphoma, T-Cell / Q000628:therapy; D008665:Metalloporphyrins / Q000627:therapeutic use*; D051379:Mice; D018579:Patient Selection; D010778:Photochemotherapy; D011166:Porphyrins / Q000627:therapeutic use*
D008665:Metalloporphyrins; D011166:Porphyrins