New approaches to the prevention and eradication of rabies.
Despite significant progress in improving the pre- and postexposure prophylaxis of human rabies, the development of better and more cost-effective vaccines and antiviral therapeutics remains a major goal for the treatment of human rabies, the control of animal rabies and particularly for the eradication of rabies virus reservoirs in terrestrial wildlife. In this review, we discuss the structural requirements for an effective rabies vaccine, as well as new strategies currently in use for the development of safer and more potent rabies vaccines for rabies prophylaxis and eradication. Finally, we discuss new immune therapeutics aimed at replacing the conventional administration of antirabies immunoglobulin used in rabies post-exposure prophylaxis in humans.
Dietzschold
Bernhard
B
Department of Microbiology and Immunology, Thomas Jefferson University, 1020 Locust Street, Suite 459, Philadelphia, PA 19107, USA. b_dietzschold@mail.jci.tju.edu
Faber
Milosz
M
Schnell
Matthias J
MJ
D000820:Animal Diseases / Q000517:prevention & control; D000818:Animals; D000829:Animals, Domestic; D000835:Animals, Wild; D000956:Antigens, Viral / Q000276:immunology; D001733:Bites and Stings / Q000628:therapy; D003673:Defective Viruses / Q000235:genetics; D005822:Genetic Vectors / Q000235:genetics; D006736:Horses; D006801:Humans; D017921:Mastadenovirus / Q000235:genetics; D011212:Poxviridae / Q000235:genetics; D011818:Rabies / Q000517:prevention & control* / Q000662:veterinary; D011819:Rabies Vaccines / Q000276:immunology / Q000627:therapeutic use; D011820:Rabies virus / Q000276:immunology / Q000502:physiology / Q000648:ultrastructure; D012209:Rhabdoviridae / Q000235:genetics; D014764:Viral Proteins / Q000276:immunology
D000956:Antigens, Viral; D011819:Rabies Vaccines; D014764:Viral Proteins