title: [Alveolar hemorrhage as a possible adverse drug reaction by gefitinib (ZD1839, Iressa)].
abstract: We experienced a case in which severe alveolar hemorrhage occurred in the course of gefitinib therapy. A 56-year-old man with non-small cell lung cancer had been treated with CDDP + CPT-11, CDDP + GEM + VNR, CDDP + TXT. After the chemotherapy with these regimens was found to be ineffective, daily oral gefitinib was started. Four weeks later, the patient complained of cough, bloody sputum and dyspnea. Chest X-ray and CT showed bilateral infiltrations with air bronchogram. Fiberoptic bronchoscopy revealed alveolar hemorrhage with an increase of lymphocytes in the BALF. After the cessation of gefitinib therapy and the administration of steroid, he gradually recovered.
authors.affiliation: Dept. of Respiratory Diseases, Tokyo Metropolitan Komagome Hospital.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Ieki
authors.forename: Erika
authors.initials: E
authors.lastname: Saitoh
authors.forename: Emi
authors.initials: E
authors.lastname: Hashimoto
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ohta
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yuasa
authors.forename: Mari
authors.initials: M
authors.lastname: Iguchi
authors.forename: Tatsuru
authors.initials: T
authors.lastname: Okamura
authors.forename: Masahiko
authors.initials: M
authors.lastname: Shibuya
authors.forename: Sachiko
authors.initials: S
authors.lastname: Moriyama
authors.forename: Hajime
authors.initials: H
authors.lastname: Goto
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000077156:Gefitinib; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D008171:Lung Diseases / Q000209:etiology*; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli; D011799:Quinazolines / Q000009:adverse effects*; D012131:Respiratory Insufficiency / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; D000077156:Gefitinib