The effect of apheresis on adhesion molecules.
The adhesion molecules on the leukocytes and the endothelial cells mediate interaction between their cells. The plasma levels of soluble adhesion molecules increase in patients with ischemic heart disease, atherosclerotic aortic disease. Hypercholesterolemia is one of risk factors for atherosclerosis, and it is considered that the expression of adhesion molecules in endothelial cells is related to the development of atherosclerosis. Low-density lipoprotein (LDL) apheresis has been applied to patients with hypercholesterolemia. LDL apheresis may have an effect on adhesion molecules in patients with hypercholesterolemia.
Motohashi
Kazuko
K
Tokatsu Clinic Hospital, Matsudo-city, Chiba, Japan. tchl@cd.mbn.or.jp
Yamane
Shingo
S
D001161:Arteriosclerosis / Q000517:prevention & control*; D015815:Cell Adhesion Molecules / Q000502:physiology*; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000628:therapy*; D018799:Intercellular Adhesion Molecule-1 / Q000502:physiology; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D010956:Plasmapheresis / Q000379:methods*; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D019010:Vascular Cell Adhesion Molecule-1 / Q000502:physiology
D015815:Cell Adhesion Molecules; D008077:Lipoproteins, LDL; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1