Potential roles of insulin and IGF-1 in Alzheimer's disease.
Aging is characterized by a significant decline of metabolic and hormonal functions, which often facilitates the onset of severe age-associated pathologies. One outstanding example of this is the reported association of deranged signaling by insulin and insulin-like-growth-factor 1 (IGF-1) with Alzheimer's disease (AD). Recent compelling biological data reveal effects of insulin and IGF-1 on molecular and cellular mechanisms underlying the pathology of AD. This review discusses available biological data that highlight the therapeutic potential of the insulin-IGF-1 signaling pathway in AD.
Gasparini
Laura
L
Nicox Research Institute, Via Ariosto 21, 20091 Bresso, Milan, Italy. gasparini@nicox.it
Xu
Huaxi
H
D000375:Aging / Q000502:physiology; D000544:Alzheimer Disease / Q000503:physiopathology*; D000686:Amyloidosis / Q000503:physiopathology*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D016874:Neurofibrillary Tangles / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction; D016875:tau Proteins / Q000378:metabolism
D007328:Insulin; D016875:tau Proteins; D007334:Insulin-Like Growth Factor I