[Discovery of MHC restriction in antigen recognition of T cells].
T cell can only recognize specific antigenic peptide-MHC complex on antigen-presenting cell. This is MHC restriction in antigen recognition of T cell. This phenomenon was discovered by an Austrian scientist Peter. C. Doherty and a Swedish scientist Rolf. M. Zinkernagel by chance. Then, in order to explain the phenomenon, they proposed two hypotheses: dual receptor and modified self. In the during following 20 years numbers of scientists spent great amount of time in the study of the phenomenon. The process of cell-mediated immune response becomes clear, which greatly promotes the advancing of immunology and many related disciplines.
Lan
Gong-tao
GT
Department of Medicine, PUMC, Beijing 100730, China.
Zhu
Li-ping
LP
Zhang
Wei
W
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008285:Major Histocompatibility Complex / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D011948:Receptors, Antigen, T-Cell