Long-term follow-up of patients after gamma intracoronary brachytherapy failure (from GAMMA-I, GAMMA-II, and SCRIPPS-III).
We report the long-term outcome of 225 patients who failed gamma-brachytherapy for in-stent restenosis. Total adverse events, target vessel revascularization, and myocardial infarction were higher after repeat percutaneous coronary intervention versus coronary artery bypass grafting. Therefore, coronary artery bypass grafting may be the preferable first-line therapy in these patients until other therapies (i.e., drug-eluting stents) are available. Shorter time from brachytherapy to radiation failure and late thrombosis after brachytherapy were independent predictors of adverse events.
Limpijankit
Thosaphol
T
Cardiovascular Research Foundation, New York, New York 10022, USA.
Mehran
Roxana
R
Mintz
Gary S
GS
Dangas
George
G
Lansky
Alexandra J
AJ
Kao
John
J
Ashby
Dale T
DT
Moussa
Issam
I
Stone
Gregg W
GW
Moses
Jeffrey W
JW
Leon
Martin B
MB
Teirstein
Paul S
PS
D001918:Brachytherapy / Q000379:methods / Q000706:statistics & numerical data*; D023903:Coronary Restenosis / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D005720:Gamma Rays / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D009204:Myocardial Revascularization / Q000706:statistics & numerical data; D012086:Reoperation / Q000706:statistics & numerical data; D016019:Survival Analysis; D013995:Time; D017211:Treatment Failure; D014481:United States / Q000453:epidemiology