Activational and organizational effects of estradiol on male behavioral neuroendocrine function.
Evidence is reviewed that establishes an essential role for estradiol, synthesized locally via aromatization of testosterone in the adult as well as the developing male nervous system of rats, ferrets, and mice, in both the organization and adult activation of neural circuits that control appetitive as well as consummatory components of masculine sexual behavior. Evidence is also reviewed suggesting that perinatal estradiol biosynthesis and action in the female's nervous system may contribute to the development of female-typical sexual behavior.
Baum
Michael J
MJ
Department of Biology, Boston University, Boston, MA 02215, USA. baum@bu.edu
D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005289:Ferrets; D008297:Male; D051379:Mice; D009490:Neurosecretory Systems / Q000502:physiology*; D051381:Rats; D012726:Sexual Behavior, Animal / Q000502:physiology*
D004958:Estradiol