title: [Light- and temperature-induced degradation of fumagillin].
abstract: The antibiotic fumagillin with amebicidal and fungicidal effects isolated from Aspergillus fumigatus is the only presently known agent for the treatment of life threatening serious microsporidiosis occurring in patients with AIDS. Fumagillin and its degradation products were measured by HPLC at given time intervals after storage under defined conditions (temperature, relative humidity). Significant degradation took place even in samples stored in freezer; therefore fumagillin drug substance should be stored below -60 degrees C. Light also induced a degradation process in fumagillin, thus it is proposed to be stored and transported in brown glass.
authors.affiliation: Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt., Budapest, Tó u. 1-5.-1045.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Agner
authors.forename: Andrea
authors.initials: A
authors.lastname: Gyórbíró
authors.forename: István
authors.initials: I
authors.lastname: Valkó
authors.forename: Lelle
authors.initials: L
authors.lastname: Vasvári-Debreczy
authors.forename: Anna
authors.initials: A
authors.lastname: Szabó
authors.forename: Gyula
authors.initials: G
authors.lastname: Farkas
authors.forename: Judit
authors.initials: J
authors.lastname: Halász
authors.forename: Benjámin
authors.initials: B
authors.lastname: Podányi
authors.forename: János
authors.initials: J
authors.lastname: Brlik
authors.forename: Kálmán
authors.initials: K
authors.lastname: Simon
authors.forename: Istvan
authors.initials: I
authors.lastname: Hermecz
mesh_terms: D000563:Amebicides / Q000737:chemistry / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use; D003510:Cyclohexanes; D004355:Drug Stability; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000528:radiation effects / Q000627:therapeutic use; D006801:Humans; D008027:Light; D012717:Sesquiterpenes; D013816:Thermodynamics
chemical_list: D000563:Amebicides; D000900:Anti-Bacterial Agents; D003510:Cyclohexanes; D005231:Fatty Acids, Unsaturated; D012717:Sesquiterpenes; C026211:fumagillin