Oxidative DNA damage of mixed copper(II) complexes with sulfonamides and 1,10-phenanthroline. Crystal structure of [Cu(N-quinolin-8-yl-p-toluenesulfonamidate)2(1,10-phenanthroline)].
Mixed coordination compounds of Cu(II) with sulfonamides and 1,10-phenanthroline as ligands have been prepared and characterised. Single crystal structural determination of the complex [Cu(N-quinolin-8-yl-p-toluenesulfonamidate)(2)(phen)] shows Cu(II) ions are located in a highly distorted octahedral environment, probably as a consequence of the Jahn-Teller effect. The FT-IR and electronic paramagnetic resonance (EPR) spectra are also discussed. The mixed complexes prepared undergo an extensive DNA cleavage in the presence of ascorbate and hydrogen peroxide. Two of the complexes have higher nucleolytic efficiency than the bis(o-phenanthroline)copper(II) complex.
Macías
Benigno
B
Departamento de Química Inorgánica, Facultad de Farmacia, Campus Unamuno, Universidad de Salamanca, 37007, Salamanca, Spain. bmacias@usal.es
García
Isabel
I
Villa
María V
MV
Borrás
Joaquín
J
González-Alvarez
Marta
M
Castiñeiras
Alfonso
A
D003300:Copper / Q000737:chemistry*; D003460:Crystallization; D004249:DNA Damage; D006868:Hydrolysis / Q000187:drug effects; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010084:Oxidation-Reduction; D010618:Phenanthrolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010957:Plasmids / Q000187:drug effects / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism
D009942:Organometallic Compounds; D010618:Phenanthrolines; D017382:Reactive Oxygen Species; D013449:Sulfonamides; D003300:Copper; D013482:Superoxide Dismutase; C025205:1,10-phenanthroline