Synchronous presentation of an Askin tumor and a plasmacytoma in an adult patient.
Askin tumor, or malignant small round cell tumor of the thoracopulmonary region, is an extremely infrequent entity occurring primarily in children and adolescents. Its histopathologic and cytogenetic features suggest that it belongs to the family of Ewing's sarcoma and primitive neuroectodermal tumors. We report the case of a 43-year-old woman affected by an Askin tumor with bone metastases at diagnosis, presenting synchronously with a plasmacytoma. This is the first reported case of the simultaneous occurrence of an Askin tumor and a malignant hemopathy. The progression of the former and the remission of the plasmacytoma during chemotherapy were remarkable, since Askin tumor treatment shares drugs used for the treatment of plasma cell tumors. Given the infrequent presentation of these diseases in a young adult and the coexistence of two neoplasias characterized by typical chromosomal abnormalities, we consider the possibility of a genetic cancer susceptibility in our patient.
Fresco
Rodrigo
R
Servicio de Oncología Clínica, Hospital de Clínicas, Facultad de Medicina, Montevideo, Uruguay. rfresco@hc.edu.uy
Saldombide
Lyber
L
Suárez
Liliana
L
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy; D005260:Female; D006801:Humans; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D010954:Plasmacytoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D012074:Remission Induction; D013899:Thoracic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed