title: Taurine regulates corticotropin secretion at the level of the supraoptic nucleus during stress in rats.
abstract: We studied the consequence of taurine release within the supraoptic nucleus (SON) for the hormonal stress response. Rats were chronically implanted with both microdialysis probes in the SON and jugular venous catheters. Three days later the animals received either Ringer's solution or a specific taurine antagonist via retrodialysis directly into the SON during a 10-min forced swimming session, while simultaneously blood samples were collected. Compared to the Ringer's control, treatment with the taurine antagonist significantly attenuated the increase in plasma corticotropin concentration caused by the stressor exposure (P < 0.05, analysis of variance). This finding supports the hypothesis that the hypothalamic-neurohypophysial system is a potent regulator of the hormonal stress response and suggests an important role for taurine in this context.
authors.affiliation: Otto-von-Guericke-Universität, Institut für Medizinische Neurobiologie, Leipziger Strasse 44, D-39120, Magdeburg, Germany. mario.engelmann@medizin.uni-magdeburg.de
authors.forename: Mario
authors.initials: M
authors.lastname: Engelmann
authors.forename: Rainer
authors.initials: R
authors.lastname: Landgraf
authors.forename: Carsten T
authors.initials: CT
authors.lastname: Wotjak
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D005938:Glucocorticoids / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000378:metabolism* / Q000503:physiopathology; D013495:Supraoptic Nucleus / Q000187:drug effects / Q000378:metabolism*; D013654:Taurine / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D005938:Glucocorticoids; D013654:Taurine; D000324:Adrenocorticotropic Hormone