[Effect of drug therapy on frequency of adequate discharges of implanted cardioverter defibrillator].
Effect of concomitant antiarrhythmic therapy (amiodarone, sotalol, beta-adrenoblockers, calcium antagonists) on frequency of adequate discharges of implantable cardioverter defibrillators was studied in 149 patients. Amiodarone and sotalol significantly decreased frequency of life threatening arrhythmias (p=0.018) and defibrillator discharges(p=0.028). Beta-blockers and calcium antagonists did not affect significantly frequency of discharges. None of the antiarrhythmic drugs caused modification of ventricular tachycardia sufficient to prevent its recognition. These results can be utilized in recommendations of antiarrhythmic drug therapy in patients with implanted cardioverter defibrillators.
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D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000638:Amiodarone / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000628:therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D017147:Defibrillators, Implantable; D004554:Electric Countershock / Q000295:instrumentation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013015:Sotalol / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D013015:Sotalol; D000638:Amiodarone