Gene switching by metabolic enzymes--how did you get on the invitation list?
Histone gene expression in mammalian cells is codependent upon the Oct-1 transcription factor and its cognate, OCA-S coactivator complex. Surprisingly, GADPH plays an essential role in the OCA-S complex and confers redox dependence upon the in vitro transcription of histone genes.
McKnight
Steve
S
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
D002467:Cell Nucleus / Q000201:enzymology; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D015870:Gene Expression; D024601:Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000235:genetics*; D051863:Host Cell Factor C1; D006801:Humans; D050811:Octamer Transcription Factor-1; D011401:Promoter Regions, Genetic; D017434:Protein Structure, Tertiary; D016196:S Phase; D015534:Trans-Activators / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D004268:DNA-Binding Proteins; C497692:HCFC1 protein, human; D006657:Histones; D051863:Host Cell Factor C1; D050811:Octamer Transcription Factor-1; C494165:POU2F1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D024601:Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+)