Survivin expression is significantly linked to the dedifferentiation of thyroid carcinoma.
Survivin is a novel member of the apoptosis protein inhibitors, but according to previous reports, it is also significantly linked to cell proliferating activity. In this study, we investigated the expression of survivin in thyroid neoplasms. Survivin was only occasionally expressed in normal follicular cells, whereas in follicular and papillary carcinomas, about 20% of cases were positive for survivin. The incidence was significantly higher in advanced stage papillary carcinoma (p=0.0080) and papillary and follicular carcinomas with poorly differentiated lesions (p=0.0150). In anaplastic carcinoma, survivin positivity was observed in 84% of the cases, which was in significantly higher incidence than in papillary or follicular carcinoma (p<0.0001). These results suggest that survivin is strongly related to the dedifferentiation of thyroid carcinoma.
Ito
Yasuhiro
Y
Department of Surgery, Kuma Hospital, Kobe 650-0011, Japan. ito01@kuma-h.or.jp
Yoshida
Hiroshi
H
Uruno
Takashi
T
Nakano
Keiichi
K
Miya
Akihiro
A
Kobayashi
Kaoru
K
Yokozawa
Tamotsu
T
Matsuzuka
Fumio
F
Matsuura
Nariaki
N
Kakudo
Kennichi
K
Kuma
Kanji
K
Miyauchi
Akira
A
D018263:Adenocarcinoma, Follicular / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D002277:Carcinoma / Q000378:metabolism*; D002454:Cell Differentiation; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis*; D009363:Neoplasm Proteins; D000077022:Survivin; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin