title: Current drug use as risk factor for erectile dysfunction: results from an Italian epidemiological study.
abstract: Several drugs have been associated with an increased risk of erectile dysfunction (ED). We analysed the role of pharmacological treatments on the risk of ED using data from a cross-sectional study on prevalence and risk factors for ED in the general population in Italy. A total of 2450 men aged more than 18 years were randomly identified by 143 general practioners (GP) among their registered patients and invited to a confidential interview by their GP. Patients were asked 'about their ability to achieve and maintain an erection sufficient for satisfactory sexual performance'. If they were dissatisfied, they were defined as having ED. Out of the 2450 men identified, 440 (18%) refused to participate. The present analysis therefore includes information on 2010 men. After adjustment for related pathologies, anxiolytics and antidepressants showed insignificantly higher odds ratio (ORs, respectively, 1.7 and 2.1); antipsychotic drug use significantly increased the risk of ED (OR 9.0, 95% confidence interval, CI 1.8-44.4). Diuretics (OR 3.1, 95% CI 1.4-6.9) and anticholinergic drugs (OR 12.8, 95% CI 2.7-60.1) were associated with ED risk. No association emerged between ED and H2 antagonists, anticholesterolemic or hypoglycemic drugs. In conclusion, after taking account of related pathologies, our results suggest that men treated with antipsychotic, diuretic and anticholinergic drugs are at greater risk of ED.
authors.affiliation: Istituto di Ricerche Farmacologiche 'Mario Negri', Milano, Italy. ricci@marionegri.it
authors.forename: E
authors.initials: E
authors.lastname: Ricci
authors.forename: F
authors.initials: F
authors.lastname: Parazzini
authors.forename: V
authors.initials: V
authors.lastname: Mirone
authors.forename: C
authors.initials: C
authors.lastname: Imbimbo
authors.forename: A
authors.initials: A
authors.lastname: Palmieri
authors.forename: A
authors.initials: A
authors.lastname: Bortolotti
authors.forename: E
authors.initials: E
authors.lastname: Di Cintio
authors.forename: M
authors.initials: M
authors.lastname: Landoni
authors.forename: M
authors.initials: M
authors.lastname: Lavezzari
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D018680:Cholinergic Antagonists / Q000009:adverse effects*; D004232:Diuretics / Q000009:adverse effects*; D007172:Erectile Dysfunction / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D014150:Antipsychotic Agents; D018680:Cholinergic Antagonists; D004232:Diuretics