Inactivating chromosomes: a macro domain that minimizes transcription.
The histone variant macroH2A plays a role in mammalian chromosome X inactivation. Recent data suggest its unusual C-terminal macro domain may be an enzyme that regulates the ADP-ribosylation of chromatin. MacroH2A could thus help correct gene dosage between males and females using a novel epigenetic mark.
Ladurner
Andreas G
AG
Gene Expression Programme and Structural and Computational Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
D000246:Adenosine Diphosphate Ribose / Q000378:metabolism; D000818:Animals; D020134:Catalytic Domain / Q000235:genetics; D002875:Chromosomes / Q000235:genetics*; D004303:Dosage Compensation, Genetic; D005057:Eukaryotic Cells / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics; D006657:Histones / Q000235:genetics*; D006801:Humans; D037941:Silencer Elements, Transcriptional / Q000235:genetics*
D006657:Histones; C120756:macroH2A histone; D000246:Adenosine Diphosphate Ribose