title: Understanding the cell biology of antigen presentation: the dendritic cell contribution.
abstract: The study of the cell biology of antigen processing and presentation has greatly contributed to our understanding of the immune response. The work of many immunologically inclined cell biologists has also permitted us to gain new insights on cellular mechanisms shared by many cell types. Dendritic cells are master regulators of the immune system and consequently have received a lot of attention in recent years. With the aim of controlling antigen processing and presentation, the solutions used by dendritic cells to respond to environmental changes are numerous and surprising. In the presence of pathogens, dendritic cells regulate strongly their endocytic pathway by interfering with uptake, proteolysis, membrane dynamics and transport in and out of the lysosome to become the most potent antigen-presenting cells known.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, CNRS-INSERM-Université de la Méditerranée, Campus de Luminy, Case 906, 13288, Cedex 09, Marseille, France. gatti@ciml.univ-mrs.fr
authors.forename: Evelina
authors.initials: E
authors.lastname: Gatti
authors.forename: Philippe
authors.initials: P
authors.lastname: Pierre
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000941:Antigens / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology*; D004705:Endocytosis / Q000276:immunology*; D011992:Endosomes / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D008247:Lysosomes / Q000276:immunology / Q000378:metabolism; D021381:Protein Transport / Q000276:immunology
chemical_list: D000941:Antigens; D000949:Histocompatibility Antigens Class II