title: Distribution of ventilation in lung transplant recipients: evaluation by dynamic 3He-MRI with lung motion correction.
abstract: OBJECTIVE
  The ability of motion corrected dynamic 3He-magnetic resonance imaging (MRI) to discriminate distributional patterns of inhaled hyperpolarized 3He between different groups of lung transplant recipients was evaluated.
  
  
  METHODS
  An ultrafast low-angle shot 2D sequence (temporal resolution 128 ms) was used for ventilation 3He-MRI of 11 single and 6 double lung transplant recipients. After digital motion correction, signal kinetics were evaluated in a tracheal and 7 pulmonary regions of interest. Results from grafts and native lungs as well as from normal and rejected grafts were compared with each other and to reference values from healthy subjects.
  
  
  RESULTS
  In emphysema patients, median alveolar rise time, a parameter for increase of alveolar signal, was 0.28 seconds for the graft and 0.48 seconds for the native lung, in fibrosis patients its median was 0.46 seconds for the graft and 0.21 seconds for the native lung. In double lung recipients, alveolar rise time was 0.29 seconds in normal and clinically rejected grafts.
  
  
  CONCLUSIONS
  Dynamic ventilation 3He-MRI discriminated normal lung grafts from diseased native lungs in single lung recipients. Graft rejection in double lung recipients could not be discriminated.
authors.affiliation: Department of Radiology, Klinikum Universitaet Mainz, Mainz, Germany. kgast@radiologie.klinik.uni-mainz.de
authors.forename: Klaus Kurt
authors.initials: KK
authors.lastname: Gast
authors.forename: Michael Ulrich
authors.initials: MU
authors.lastname: Puderbach
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rodriguez
authors.forename: Balthasar
authors.initials: B
authors.lastname: Eberle
authors.forename: Klaus
authors.initials: K
authors.lastname: Markstaller
authors.forename: Frank
authors.initials: F
authors.lastname: Knitz
authors.forename: Joerg
authors.initials: J
authors.lastname: Schmiedeskamp
authors.forename: Norbert
authors.initials: N
authors.lastname: Weiler
authors.forename: Wolfgang G
authors.initials: WG
authors.lastname: Schreiber
authors.forename: Eckhardt
authors.initials: E
authors.lastname: Mayer
authors.forename: Manfred
authors.initials: M
authors.lastname: Thelen
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
mesh_terms: D005260:Female; D006371:Helium; D006801:Humans; D007554:Isotopes; D008168:Lung / Q000033:anatomy & histology*; D016040:Lung Transplantation; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009038:Motion; D011656:Pulmonary Emphysema / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000473:pathology; D014692:Ventilation-Perfusion Ratio
chemical_list: D007554:Isotopes; D006371:Helium