title: Evaluation of antitussive potential of Ionidium suffruticosam Ging. (Violaceae) extract in albino mice.
abstract: The present study was carried out to evaluate the antitussive potential of methanol extract of Ionidium suffruticosam Ging. (Violaceae) which was investigated for its effect on a cough model induced by sulfur dioxide gas in albino mice. It exhibited significant dose-dependent antitussive activity when compared with the control, 250 and 500 mg/kg (p.o.) of the extract showing 28.37% and 54.16% inhibition of the cough with respect to control group. The antitussive activity of the extract was comparable to that of codeine phosphate, a prototype antitussive agent.
authors.affiliation: Division of Pharmacognosy & Phytochemistry, Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadavpur University, Calcutta, India.
authors.forename: R
authors.initials: R
authors.lastname: Boominathan
authors.forename: B Parimala
authors.initials: BP
authors.lastname: Devi
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Mandal
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003371:Cough / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013458:Sulfur Dioxide; D029649:Violaceae
chemical_list: D000996:Antitussive Agents; D010936:Plant Extracts; D013458:Sulfur Dioxide