title: Liver transplantation in patients with fulminant hepatitis B: experience in Canton, China.
abstract: OBJECTIVE
  To investigate the effect of orthotopic liver transplantation on fulminant hepatitis B and the preventive efficiency of lamivudine on recurrence of hepatitis B in China.
  
  
  METHODS
  Ten patients with fulminant hepatitis B received orthotopic liver transplantation under veno-venous bypass. All patients had preoperatively serious jaundice, ascites and coagulopathy, and of whom 7 with encephalopathy, 2 with acute renal failure, and 1 with gastro-hemorrhage. RUSULT: Seven of the 10 patients have survived for 3 approximately 18 months, but 3 died of multi-organ failure or recurrence of fulminant hepatitis B. Seven survivors took lamivudine and 6 of them have survived for 3 approximately 18 months without the signs of recurrence of hepatitis B.
  
  
  CONCLUSIONS
  Orthotopic liver transplantation is an effective therapy for fulminant hepatitis B, and lamivudine may prevent recurrence of hepatitis B after transplantation.
authors.affiliation: Transplantation Center, Affiliated First Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Zhu
authors.forename: Guihua
authors.initials: G
authors.lastname: Chen
authors.forename: Xiaoshun
authors.initials: X
authors.lastname: He
authors.forename: Minqiang
authors.initials: M
authors.lastname: Lu
authors.forename: Guodong
authors.initials: G
authors.lastname: Wang
authors.forename: Changjie
authors.initials: C
authors.lastname: Cai
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Jiefu
authors.initials: J
authors.lastname: Huang
mesh_terms: D000328:Adult; D006501:Hepatic Encephalopathy / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D006509:Hepatitis B / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D015996:Survival Rate
chemical_list: D019259:Lamivudine