Studies on the effect of monosodium glutamate [MSG] administration on some antioxidant enzymes in the arterial tissue of adult male mice.
The subcutaneous administration of monosodium glutamate to normal adult male mice at dose levels of 4 and 8 mg/g body weight caused a significant increase in lipid peroxidation level in the arterial tissue. The levels of total sulfhydryl and protein-bound sulfhydryl groups were found to be significantly increased, whereas non-protein-bound sulfhydryl, representing the glutathione level, was significantly decreased. It was also observed that the administration of monosodium glutamate at a dose level of 4 mg/g body weight and above induced oxidative stress by significantly lowering the activities of antioxidant enzymes like superoxide dismutases, catalase, and glutathione metabolizing enzymes like glutathione reductase and glutathione peroxidase in the arterial tissue.
Singh
Kuldip
K
Department of Biochemistry, Panjab University, Chandigarh-160014, India.
Ahluwalia
Pushpa
P
D000704:Analysis of Variance; D000818:Animals; D001158:Arteries / Q000187:drug effects* / Q000201:enzymology; D002374:Catalase / Q000187:drug effects; D005503:Food Additives / Q000008:administration & dosage*; D005979:Glutathione Peroxidase / Q000187:drug effects; D005980:Glutathione Reductase / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D010088:Oxidoreductases / Q000187:drug effects*; D012970:Sodium Glutamate / Q000008:administration & dosage*; D013438:Sulfhydryl Compounds / Q000032:analysis; D013482:Superoxide Dismutase / Q000187:drug effects
D005503:Food Additives; D013438:Sulfhydryl Compounds; D010088:Oxidoreductases; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D012970:Sodium Glutamate