Alzheimer's disease as a disconnection syndrome?
This paper reviews the growing amount of evidence supporting the hypothesis that Alzheimer's disease includes a disconnection syndrome. This evidence came mainly from neuropathological, electrophysiological, and neuroimaging studies. Moreover, a few recent neuropsychological studies have also explored the effects of a disconnection between cerebral areas on cognitive functioning. Finally, and more generally, the contribution of this interpretation to the understanding of Alzheimer's disease cognitive deficits is considered.
Delbeuck
X
X
Cognitive Psychopathology Unit, University of Geneva, Geneva, Switzerland. Xavier.Delbeuck@pse.unige.ch
Van der Linden
M
M
Collette
F
F
D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology; D003952:Diagnostic Imaging; D004292:Dominance, Cerebral / Q000502:physiology*; D006801:Humans; D009434:Neural Pathways / Q000473:pathology* / Q000503:physiopathology; D016874:Neurofibrillary Tangles / Q000473:pathology; D009483:Neuropsychological Tests; D058225:Plaque, Amyloid / Q000473:pathology