title: Elevated levels of circulating adhesion molecules in patients with active pulmonary tuberculosis.
abstract: OBJECTIVE
  Recent studies have indicated the importance of cell adhesion molecules in the pathogenesis of various inflammatory lung diseases. Our study was designed to determine whether five soluble adhesion molecules including soluble L-, E- and P-selectin (sL-, sE- and sP-selectin), intercellular adhesion molecule-1 (sICAM-1), and vascular cell adhesion molecule-1 (sVCAM-1) in serum reflect the severity of active pulmonary tuberculosis (TB), and whether there is a distinct profile of these soluble molecules in this disease.
  
  
  METHODS
  Using enzyme-linked immunosorbent assays, we measured the serum levels of these five soluble adhesion molecules in 31 patients with active TB and 11 healthy volunteers.
  
  
  RESULTS
  Serum levels of sE-selectin, sP-selectin and sICAM-1, but not sL-selectin or sVCAM-1, were significantly higher in patients with active TB than in the control subjects (P < 0.001, each). Significant correlations were detected only between serum levels of sE-selectin and sP-selectin, sE-selectin and sICAM-1, and sP-selectin and sICAM-1. There was a significant correlation between the Gaffky scale result (a scale assessing the number of mycobacteria bacilli present) and all of the above adhesion molecules, except for sL-selectin. Serum levels of sE-selectin, sL-selectin and sICAM-1 also correlated with the CXR radiological score. Higher levels of sL-selectin and sICAM-1 were detected in the serum of patients with radiological cavity formation compared to those without. The ESR, C-reactive protein and circulating neutrophil counts all correlated significantly with sE-selectin, sP-selectin, sICAM-1 and sVCAM-1.
  
  
  CONCLUSIONS
  The results suggest that there is a distinct profile of soluble adhesion molecules in active pulmonary TB and that sE-selectin, sP-selectin, and especially sICAM-1 appear to be the most sensitive clinical measures of disease severity.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan. hmukae@net.nagasaki-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Ashitani
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Tokojima
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Ihi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
authors.forename: Shigeru
authors.initials: S
authors.lastname: Matsukura
mesh_terms: D000328:Adult; D000368:Aged; D015815:Cell Adhesion Molecules / Q000097:blood*; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000145:classification
chemical_list: D015815:Cell Adhesion Molecules