title: Functional optical coherence tomography for detecting neural activity through scattering changes.
abstract: We have demonstrated functional optical coherence tomography (fOCT) for neural imaging by detecting scattering changes during the propagation of action potentials through neural tissue. OCT images of nerve fibers from the abdominal ganglion of the sea slug Aplysia californica were taken before, during, and after electrical stimulation. Images acquired during stimulation showed localized reversible increases in scattering compared with those acquired before stimulation. Motion-mode OCT images of nerve fibers showed transient scattering changes from spontaneous action potentials. These results demonstrate that OCT is sensitive to the optical changes in electrically active nerve fibers.
authors.affiliation: Department of Electrical and Computer Engineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
authors.forename: Mariya
authors.initials: M
authors.lastname: Lazebnik
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Marks
authors.forename: Kurt
authors.initials: K
authors.lastname: Potgieter
authors.forename: Rhanor
authors.initials: R
authors.lastname: Gillette
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Boppart
mesh_terms: D000005:Abdomen / Q000294:innervation*; D000200:Action Potentials; D000818:Animals; D001048:Aplysia; D004558:Electric Stimulation; D005724:Ganglia / Q000502:physiology; D055095:Optics and Photonics; D012542:Scattering, Radiation; D014054:Tomography