Evaluation of antitussive potential of Ionidium suffruticosam Ging. (Violaceae) extract in albino mice.
The present study was carried out to evaluate the antitussive potential of methanol extract of Ionidium suffruticosam Ging. (Violaceae) which was investigated for its effect on a cough model induced by sulfur dioxide gas in albino mice. It exhibited significant dose-dependent antitussive activity when compared with the control, 250 and 500 mg/kg (p.o.) of the extract showing 28.37% and 54.16% inhibition of the cough with respect to control group. The antitussive activity of the extract was comparable to that of codeine phosphate, a prototype antitussive agent.
Boominathan
R
R
Division of Pharmacognosy & Phytochemistry, Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadavpur University, Calcutta, India.
Devi
B Parimala
BP
Mandal
Subhash C
SC
D000284:Administration, Oral; D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003371:Cough / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013458:Sulfur Dioxide; D029649:Violaceae
D000996:Antitussive Agents; D010936:Plant Extracts; D013458:Sulfur Dioxide