Factors determining the post-operative hypo-albuminaemia in cancer patients--stepwise regression analysis.
OBJECTIVE
To investigate factors influencing post-operative hypo-albuminaemia in cancer patients, with special reference to low dose albumin and/or immunoglobulins administration.


METHODS
In 270 patients with malignant neoplasms, who underwent extensive chest and/or abdominal surgery, albumin concentrations on the first four postoperative days were examined. One hundred and three high-risk patients received human immunoglobulins intravenously; 44 were given albumin. Univariate and multivariate regression analyses were used to determine the factors influencing albuminaemia on the first four postoperative days.


RESULTS
Mean nadir of hypo-albuminaemia occurred on the third postoperative day. In the multivariate analysis, a positive correlation was found between postoperative albuminaemia and pre-operative albuminaemia (b = 0.4919; p = 0.0000) as well as male gender (b = 2.0939; p = 0.0025). A negative correlation was found with the duration of surgery (b = -0.0416; p = 0.0212), pre-operative plasma protein (b = -0.2118, p = 0.0130) and postoperative immunoglobulin administration (b = -1.8858, p = 0.0074).


CONCLUSIONS
Postoperative albuminaemia is positively correlated with pre-operative albuminaemia and male gender and negatively correlated with the duration of surgery, pre-operative proteinaemia and postoperative Ig administration.
Duda
K
K
Jagiellonian University, Oncology Center, Cracow, Poland.
Kołodziejski
L
L
Sokołowski
A
A
Kubisz
A
A
Łobaziewicz
W
W
Komorowski
A L
AL
Marczyk
E
E
D000368:Aged; D004067:Digestive System Neoplasms / Q000601:surgery*; D004938:Esophageal Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D034141:Hypoalbuminemia / Q000453:epidemiology / Q000209:etiology*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000453:epidemiology*; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors
D016756:Immunoglobulins, Intravenous