Regulation of membrane dynamics in developing epithelia.
A cellular understanding of developmental mechanisms embraces complex dynamic processes at the cell surface. Studies of trafficking pathways and of associated cytoskeletal elements in genetically tractable organisms allow a better analysis of the mechanisms underlying the control of cell polarization and tissue morphogenesis at different stages of animal development. It is now possible to identify signalling pathways that provide the temporal triggers and/or spatial cues to regulate core cellular effectors during migration, morphogenesis and the formation of epithelia.
Lecuit
Thomas
T
Institut de Biologie du Développement de Marseille, Laboratoire de Génétique et de Physiologie du Développement, Campus de Luminy, case 907, 13288 Marseille, cedex 09, France. lecuit@ibdm.univ-mrs/fr
D000818:Animals; D002465:Cell Movement; D016764:Cell Polarity; D004848:Epithelium / Q000196:embryology*; D008566:Membranes / Q000196:embryology; D009024:Morphogenesis; D015398:Signal Transduction