title: Persistent subretinal indocyanine green induces retinal pigment epithelium atrophy.
abstract: OBJECTIVE
  To describe a case of a patient with macular hole with subretinal indocyanine green (ICG) during vitrectomy.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  A 66-year-old woman with macular hole underwent a vitrectomy with ICG.
  
  
  RESULTS
  After application of ICG into the vitreous, ICG was introduced in the subretinal space. Indocyanine green was found to be present for more than 6 months. Retinal pigment epithelium atrophy appeared at the site of the lesion.
  
  
  CONCLUSIONS
  Although ICG may be a useful tool for distinguishing the internal limiting membrane and other tissues careful application is required to prevent side effects.
authors.affiliation: Department of Ophthalmology, Kumamoto University School of Medicine, Honjo, Kumamoto, Japan. ahirata@kumamoto-u.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Hirata
authors.forename: Yasuya
authors.initials: Y
authors.lastname: Inomata
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kawaji
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Tanihara
mesh_terms: D000368:Aged; D001284:Atrophy; D001485:Basement Membrane / Q000601:surgery; D004396:Coloring Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007208:Indocyanine Green / Q000009:adverse effects*; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D012164:Retinal Diseases / Q000139:chemically induced* / Q000473:pathology; D012167:Retinal Perforations / Q000601:surgery; D014821:Vitrectomy
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green