title: Synthesis of 2,3-dihydroinosine derivatives by reduction using BH3-THF.
abstract: A novel reductive method for the chemical modification of nucleosides is described. Reaction of inosine derivatives with boran-THF resulted in the regioselective reduction of purine ring to afford the corresponding 2,3-dihydroinosine derivatives in moderate yields.
authors.affiliation: Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hirota
authors.forename: R
authors.initials: R
authors.lastname: Hattori
authors.forename: H
authors.initials: H
authors.lastname: Sajiki
authors.forename: Y
authors.initials: Y
authors.lastname: Monguchi
authors.forename: O
authors.initials: O
authors.lastname: Muraoka
authors.forename: G
authors.initials: G
authors.lastname: Tanabe
mesh_terms: D001880:Boranes; D007288:Inosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D001880:Boranes; D007288:Inosine