title: Cytotoxic anthraquinones from the stems of Rubia wallichiana Decne.
abstract: From the stems of Rubia wallichiana DECNE, thirty-four structurally related compounds were isolated and identified. Three of them, namely rubiawallin-A (1), -B (2), and -C (3), constitute the first report of their occurrence from the natural source. Their structures were determined by comprehensive analyses of their 1D and 2D NMR, and electron impact (EI) mass spectral data. Furthermore, an in vitro screening of cytotoxicity of the isolated compounds was also evaluated. Among the testing compounds, 1-hydroxy-2-hydroxymethyl-3-methoxyanthraquinone (4) demonstrated most effective cytotoxicity towards Hepa-3B and Colo-205 cells.
authors.affiliation: Department of Chemistry, National Cheng Kung University, Taiwan. tswu@mail.ncu.edu.tw
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
authors.forename: Dau-Min
authors.initials: DM
authors.lastname: Lin
authors.forename: Li-Shian
authors.initials: LS
authors.lastname: Shi
authors.forename: Amooru Gangaiah
authors.initials: AG
authors.lastname: Damu
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.forename: Yao-Hau
authors.initials: YH
authors.lastname: Kuo
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000633:toxicity*; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry*; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity; D018547:Plant Stems; D045470:Rubia / Q000633:toxicity*
chemical_list: D000880:Anthraquinones; D003603:Cytotoxins; D010936:Plant Extracts