[The association of two single nucleotide polymorphisms in PRKCZ and UTS2 respectively with type 2 diabetes in Han people of northern China].
OBJECTIVE
To probe the candidate susceptibility gene (s) of type 2 diabetes in the formal mapping region, 1p36.33-p36.23, in Han people of Northern China using single nucleotide polymorphisms (SNPs).


METHODS
23 SNPs located in 10 candidate genes in the mapping region were chosen from public SNP domain by bioinformatic methods and single base extension (SBE) method were used to genotype the loci in 192 sporadic type 2 diabetes patients and 172 normal individuals to perform case-control study.


RESULTS
Among the 23 SNPs, 8 were found to be common in Chinese population. There were statistically different in the allele frequency of 2 SNP, rs436045 in the protein kinase C/xi gene and rs228648 in Urotensin II gene between case and control groups.


CONCLUSIONS
The two SNP may be associated with type 2 diabetes in Han people of China, which makes base for further study of the relation between the genes they located with type 2 diabetes.
Sun
Hong-xia
HX
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China.
Du
Wei-nan
WN
Zuo
Jin
J
Wu
Guo-dong
GD
Shi
Gui-bin
GB
Shen
Yan
Y
Qiang
Bo-qin
BQ
Yao
Zhi-jian
ZJ
Hang
Jian-mei
JM
Wang
Heng
H
Huang
Wei
W
Chen
Zhu
Z
Fang
Fu-de
FD
D000483:Alleles; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005006:Ethnicity; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011493:Protein Kinase C / Q000235:genetics*; D014579:Urotensins / Q000235:genetics*
D014579:Urotensins; C029677:urotensin II; D011493:Protein Kinase C