Oxidizability of apolipoprotein B-containing lipoproteins, levels of lipid peroxidation products and antioxidants in normal pregnancy.
OBJECTIVE
The object was to assess oxidizability of apolipoprotein B-containing lipoproteins, levels of lipid peroxidation products and antioxidants in normal pregnancy.


METHODS
Serum malondialdehyde, vitamin E, carotenoids, albumin, uric acid, bilirubin, triglyceride, total cholesterol levels and in vitro copper-induced oxidation of apolipoprotein B-containing lipoproteins were investigated in 21 healthy pregnant and 22 nonpregnant women. Mann-Whitney U test was used for the statistical analyses.


RESULTS
Serum malondialdehyde, vitamin E, triglyceride and total cholesterol levels were significantly higher; albumin and uric acid levels and vitamin E/triglyceride + total cholesterol and carotenoids/triglyceride + total cholesterol ratios were significantly lower in the pregnant group. Basal malondialdehyde concentrations of apolipoprotein B-containing lipoprotein fraction and Delta-malondialdehyde values determined at 30, 60, 90, 120, 150 and 180th minutes of incubation were significantly lower in the pregnant group compared to those in the non-pregnant group.


CONCLUSIONS
Although greater lipid peroxidation product levels reflect an enhanced lipid peroxidation status in normal pregnancy, apolipoprotein B-containing lipoprotein fraction of normal pregnant women compared with the nonpregnant subjects seems to be protected from oxidation.
Sarandöl
Emre
E
Department of Biochemistry, Medical Faculty, Uludağ University, 16059 Görükle, Bursa, Turkey. sarandol@uludag.edu.tr
Dirican
Melahat
M
Serdar
Zehra
Z
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001055:Apolipoproteins B / Q000737:chemistry*; D001663:Bilirubin / Q000097:blood; D002338:Carotenoids / Q000097:blood; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003300:Copper / Q000737:chemistry; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D010084:Oxidation-Reduction; D011247:Pregnancy / Q000097:blood*; D012709:Serum Albumin; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D001055:Apolipoproteins B; D012709:Serum Albumin; D014280:Triglycerides; D014810:Vitamin E; D014527:Uric Acid; D002338:Carotenoids; D008315:Malondialdehyde; D003300:Copper; D002784:Cholesterol; D001663:Bilirubin