A bad rap: Rap1 signaling and oncogenesis.
In the paper by Ishida et al. in this issue of Cancer Cell, the authors report the results of targeted inactivation of a Rap1-specific GTPase-activating protein (GAP) gene, called SPA-1, in mice. Rap1 hyperactivation was observed in hematopoietic cells, which led over time to features associated with symptoms typical of human myeloid dyslastic and myeloid proliferative diseases. The authors present additional data showing that the level of Rap1 activation is important for regulating myelopoiesis and that, in the right context, can deliver an oncogenic signal.
Largaespada
David A
DA
University of Minnesota Cancer Center, 6-160 Jackson Hall, 321 Church Street S.E., Minneapolis, MN 55455, USA. larga002@tc.umn.edu
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D020690:GTPase-Activating Proteins; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009196:Myeloproliferative Disorders / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D020827:rap1 GTP-Binding Proteins / Q000378:metabolism*
D020690:GTPase-Activating Proteins; D009687:Nuclear Proteins; C490403:SIPA1 protein, human; C091108:Sipa1 protein, mouse; D020827:rap1 GTP-Binding Proteins