Anti-angiogenic activity of tocotrienol.
The anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in vitro. Tocotrienol, but not tocopherol, inhibited both the proliferation and tube formation of bovine aortic endothelial cells, with delta-tocotrienol appearing the highest activity. Also, delta-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formation by human umbilical vein endothelial cells. Our findings suggest that tocotrienol has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis.
Inokuchi
Hitoshi
H
Food & Biodynamic Chemistry Laboratory, Graduate School of Life Science and Agriculture, Tohok University, Sendai, Japan.
Hirokane
Hisako
H
Tsuzuki
Tsuyoshi
T
Nakagawa
Kiyotaka
K
Igarashi
Miki
M
Miyazawa
Teruo
T
D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D009389:Neovascularization, Pathologic; D024508:Tocotrienols / Q000008:administration & dosage / Q000494:pharmacology*; D014471:Umbilical Veins; D042442:Vascular Endothelial Growth Factors / Q000494:pharmacology
D020533:Angiogenesis Inhibitors; D024508:Tocotrienols; D042442:Vascular Endothelial Growth Factors