title: Amiodarone-induced 2 to 1 atrioventricular block in association with prolongation of the QT interval.
abstract: The potential for development of 2 to 1 atrioventricular conduction in children with prolongation of the QT interval has been previously reported secondary to electrolytic disturbances. We report here a child who developed 2 to 1 atrioventricular conduction with prolongation of the QT interval following treatment with amiodarone for refractory supraventricular tachycardia. We highlight the importance of electrocardiographic monitoring to assess for those at risk of amiodarone toxicity, which may be manifested by prolongation of the QT interval and the simultaneous loss of atrioventricular conduction, and of equal importance the need for prompt conversion to an alternative anti-arrhythmic agent.
authors.affiliation: Lillie Frank Abercrombie Division of Pediatric Cardiology, Texas Children's Hospital and Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Colin J
authors.initials: CJ
authors.lastname: McMahon
authors.forename: William P
authors.initials: WP
authors.lastname: Laird
authors.forename: Arnold L
authors.initials: AL
authors.lastname: Fenrich
mesh_terms: D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006327:Heart Block / Q000139:chemically induced*; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D013617:Tachycardia, Supraventricular / Q000188:drug therapy
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone