Synthesis of 2,3-dihydroinosine derivatives by reduction using BH3-THF.
A novel reductive method for the chemical modification of nucleosides is described. Reaction of inosine derivatives with boran-THF resulted in the regioselective reduction of purine ring to afford the corresponding 2,3-dihydroinosine derivatives in moderate yields.
Hirota
K
K
Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan.
Hattori
R
R
Sajiki
H
H
Monguchi
Y
Y
Muraoka
O
O
Tanabe
G
G
D001880:Boranes; D007288:Inosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D001880:Boranes; D007288:Inosine