Serum levels of beta-trace protein and glomerular filtration rate--preliminary results.
The aim of this study was to evaluate the relationship between serum levels of beta-trace protein (BTP), a low molecular weight (MW) protein, and glomerular filtration rate (GFR). GFR and serum levels of BTP, and for comparison creatinine (Creat), cystatin C (Cys) and beta 2-microglobulin (beta 2M), were measured in 60 patients, with renal function ranging from normality to advanced renal failure. Serum levels of BTP progressively increased with the reduction of GFR. A good correlation was found between GFR and serum levels of BTP (r=0.918), Creat (r=0.932), Cys (r=0.937), and beta 2M (r=0.924). Furthermore, no statistically significant difference was found between BTP and Creat, Cys, beta 2M, as indicators of a moderate GFR impairment. These preliminary data indicate that BTP might be suitable as an indicator of GFR.
Donadio
Carlo
C
Unità di Nefrologia, Dipartimento di Medicina Interna, Università di Pisa, I-56100 Pisa, Italy. c.donadio@med.unipi.it
Lucchesi
Annalisa
A
Ardini
Michela
M
Donadio
Elena
E
Giordani
Roberto
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000097:blood*; D007674:Kidney Diseases / Q000097:blood; D054834:Lipocalins; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D001613:beta 2-Microglobulin / Q000097:blood
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D054834:Lipocalins; D001613:beta 2-Microglobulin; D003404:Creatinine; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase