Asymptomatic infection with Borrelia burgdorferi.
The natural history of asymptomatic seroconversion to Borrelia burgdorferi has been unclear. We report here, on the basis of a post hoc assessment, the frequency and outcome of asymptomatic seroconversion to B. burgdorferi in participants of a large Lyme disease vaccine trial. We show that infection with B. burgdorferi may be asymptomatic but that asymptomatic infection is unusual in the United States.
Steere
Allen C
AC
Division of Rheumatology/Immunology, Tufts University School of Medicine, New England Medical Center, Boston, MA, USA. asteere@partners.org
Sikand
Vijay K
VK
Schoen
Robert T
RT
Nowakowski
John
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D025065:Borrelia burgdorferi / Q000276:immunology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008193:Lyme Disease / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology* / Q000517:prevention & control*; D022123:Lyme Disease Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D016896:Treatment Outcome
D022123:Lyme Disease Vaccines