Maneuvering for advantage: the genetics of mouse susceptibility to virus infection.
Genetic studies of host susceptibility to infection contribute to our understanding of an organism's response to pathogens at the immunological, cellular, and molecular levels. In this review we describe how the study of host genetics in mouse models has helped our understanding of host defense mechanisms against viral infection, and how this knowledge can be extended to human infections. We focus especially on the innate mechanisms that function as the host's first line of defense against infection. We also discuss the main issues that confront this field, as well as its future.
Lee
Seung-Hwan
SH
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5.
Dimock
Ken
K
Gray
Douglas A
DA
Beauchemin
Nicole
N
Holmes
Kathryn V
KV
Belouchi
Majid
M
Realson
John
J
Vidal
Silvia M
SM
D000818:Animals; D002462:Cell Membrane / Q000235:genetics / Q000276:immunology; D002874:Chromosome Mapping; D020022:Genetic Predisposition to Disease; D007113:Immunity, Innate / Q000235:genetics*; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D014777:Virus Diseases / Q000276:immunology*; D014779:Virus Replication / Q000235:genetics / Q000276:immunology