[Relationship between alpha-ENaC gene Thr663Ala polymorphism and ischemic stroke].
OBJECTIVE
To determine the relationship between Thr663Ala polymorphism in amiloride-sensitive epithelial sodium channel alpha-subunit (alpha-ENaC) gene and ischemic stroke in Chinese population.


METHODS
Two hundred and ninety-four patients with cerebral infarction and 280 controls without stroke were screened by polymerase chain reaction (PCR) and corresponding Thr663Ala polymorphism probe hybridization.


RESULTS
Thr663Ala polymorphism was in agreement with Hardy-Weinberg equilibrium. Both the carriers proportion (70.75%) and the frequency (48.64%) of 663Ala allele in patients were more prevalent than that in controls (62.86% and 40.89%) (P < 0.05). The presence of at least one 663Ala allele conferred an odds ratio for stroke of 1.429 (95%CI: 1.009-2.025), and the proportion of attributable risk of population (PAR%) was 11.63%.


CONCLUSIONS
Thr 663Ala polymorphism of alpha-ENaC gene may be a genetic risk of ischemic stroke in Chinese population.
Zhao
Y
Y
Department of Hypertension, Fuwai Heart Hospital, CAMS, PUMC, Beijing 100037, China. zhaoyong 600@sohu.com
Ma
L Y
LY
Liu
Y X
YX
Wang
X Y
XY
Liu
L S
LS
Lindpaintner
K
K
D000368:Aged; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D015222:Sodium Channels / Q000235:genetics*; D020521:Stroke / Q000235:genetics*
D015222:Sodium Channels