Detection of glial fibrillary acidic protein and neurofilaments in the cerebrospinal fluid of patients with neurocysticercosis.
Neurocysticercosis (NCC) is an infection caused by Taenia solium larval metacestodes in the central nervous system. The glial fibrillary acidic protein (GFAP) and neurofilaments (NFs) can be used as markers of glial and neuronal damage, respectively. We studied the GFAP and NFs of 68, 160 and 200 kDa in the cerebrospinal fluid (CSF) of patients with NCC by Western blotting. Our results showed that patients with NCC had significantly elevated GFAP levels in the CSF compared with the control, whereas NFs of 68, 160 and 200 kDa were not detected in the CFS of NCC patients. We concluded that GFAP could be used as a marker of glial damage in the CFS of NCC patients.
Quintanar
J Luis
JL
Laboratory of Neurophysiology, Department of Physiology and Pharmacology, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Avenida Universidad 940, C.P. 20100, Aguascalientes, Aguascalientes, México. jlquinta@correo.uaa.mx
Franco
Luis Manuel
LM
Salinas
Eva
E
D000328:Adult; D000818:Animals; D015415:Biomarkers / Q000134:cerebrospinal fluid; D015153:Blotting, Western; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D020019:Neurocysticercosis / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D016900:Neurofilament Proteins / Q000134:cerebrospinal fluid*; D013621:Taenia / Q000254:growth & development
D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D016900:Neurofilament Proteins