[Progress in the studies on the relationship between the polymorphism of P22phox gene and coronary heart disease].
Reactive oxygen species (ROS) are thought to contribute to the progression of cardiovascular disease (CVD). At present, it has been known that the NADH/NADPH oxidase system is the major source of superoxide in the vascular system. Cytochrome b-245 (P22phox), which is a critical component of NADH/NADPH oxidase, plays an important role in electron transport and producing the superoxide anion. It is considerable to take attention to whether the polymorphism of P22phox gene is associated with a risk of coronary heart disease (CHD). To distinguish the relationship between them will be beneficial to elucidate the genetic mechanisms of CHD, and develop a new genetic marker to provide theoretical base for the prevention and cure of CHD.
Zhao
Jian-gong
JG
Division of Population Genetics & Prevention, Fuwai Cardiovascular Institute, CAMS, PUMC, Beijing 100037, China.
Gu
Dong-feng
DF
D003327:Coronary Disease / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics*; D009252:NADPH Dehydrogenase / Q000235:genetics*; D019255:NADPH Oxidases; D010750:Phosphoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
D005819:Genetic Markers; D026901:Membrane Transport Proteins; D010750:Phosphoproteins; D019255:NADPH Oxidases; C086986:CYBA protein, human; D009252:NADPH Dehydrogenase