Gremlin - a putative pathogenic player in progressive renal disease.
Progressive renal fibrosis is the end process of renal injury leading to kidney failure. Current therapies for chronic renal failure aim to slow this process but fail to halt its progression. As the mechanisms involved in glomerulosclerosis and tubulointerstitial fibrosis are unravelled, potential treatments for this growing clinical problem should emerge. Gremlin, a developmental regulator of bone morphogenetic proteins (BMPs), has recently been implicated in processes such as glomerulosclerosis, tubulointerstitial fibrosis and cellular hypertrophy, and may represent a novel therapeutic target in progressive renal diseases.
Dolan
Vincent
V
Centre for Integrative Biology, Conway Institute of Biomolecular and Biomedical Research, Department of Medicine and Therapeutics, University College Dublin, The Dulin Molecular Medicine Centre, Belfield, Ireland. vincent.dolan@ucd.ie
Murphy
Madeline
M
Alarcon
Pilar
P
Brady
Hugh R
HR
Hensey
Carmel
C
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000235:genetics / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000235:genetics / Q000503:physiopathology; D019281:Dimerization; D018450:Disease Progression; D025461:Feedback, Physiological; D005355:Fibrosis; D005786:Gene Expression Regulation; D005923:Glomerulosclerosis, Focal Segmental / Q000235:genetics / Q000503:physiopathology; D053823:Hedgehog Proteins; D006801:Humans; D006984:Hypertrophy; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology*; D007674:Kidney Diseases / Q000209:etiology* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009395:Nephritis, Interstitial / Q000235:genetics / Q000503:physiopathology; D051381:Rats; D015534:Trans-Activators / Q000502:physiology
D019485:Bone Morphogenetic Proteins; C486399:GREM1 protein, human; D053823:Hedgehog Proteins; D036341:Intercellular Signaling Peptides and Proteins; D015534:Trans-Activators