title: Adaptation in the respiratory control system.
abstract: Exposure to hypoxia, whether for short or prolonged periods or for repeated episodes, produces alterations in the ventilatory responses. This review presents evidence that these adaptations are likely to be mediated by adaptations in the respiratory chemoreflexes, particularly the peripheral chemoreflex, and proposes models of respiratory control explaining the observed changes in ventilation. After a brief introduction to the respiratory control system, a graphical model is developed that illustrates the operation of the system in the steady state, which will be used later. Next, the adaptations in ventilatory responses to hypoxia that have been observed are described, and methods of measuring the alterations in the chemoreflexes that might account for them are discussed. Finally, experimental data supporting the view that changes in the activity of the peripheral chemoreflex can account for the ventilatory adaptations to hypoxia are presented and incorporated into models of chemoreflex behaviour during exposures to hypoxia of various durations.
authors.affiliation: Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada. j.duffin@utoronto.ca
authors.forename: James
authors.initials: J
authors.lastname: Duffin
authors.forename: Safraaz
authors.initials: S
authors.lastname: Mahamed
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D006801:Humans; D010101:Oxygen Consumption / Q000502:physiology*; D012143:Respiratory Physiological Phenomena