Behavioral relationship between autism and fragile x syndrome.
Previous researchers have reported autistic features in children with fragile X syndrome. We compared 21 children with pervasive developmental disorders (autism group) to 15 with fragile X syndrome on the Childhood Autism Rating Scale and the Reiss Scales for Children's Dual Diagnosis. The 7 children (47%) with fragile X who scored above the Childhood Autism Rating Scale cut-off (fragile X-autism group) were more impaired than the remaining children (fragile X-no autism) on Childhood Autism Rating Scale subscales related to emotion, visual and listening responses, and communication. The autism group's Reiss scores were higher than fragile X-no autism group, but not fragile X-autism group. Although the Childhood Autism Rating Scale identified almost 50% of children with fragile X as having autism, qualitative differences may exist in specific autistic-like behaviors between children with autism and children with fragile X.
Demark
Jenny L
JL
Queen's University, Kingston, Ontario, Canada.
Feldman
Maurice A
MA
Holden
Jeanette J A
JJ
D000293:Adolescent; D001321:Autistic Disorder / Q000150:complications / Q000175:diagnosis / Q000523:psychology*; D002648:Child; D002652:Child Behavior; D002675:Child, Preschool; D005260:Female; D005600:Fragile X Syndrome / Q000150:complications / Q000175:diagnosis / Q000523:psychology*; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis / Q000209:etiology; D008297:Male; D011569:Psychiatric Status Rating Scales; D012680:Sensitivity and Specificity