Total subdiaphragmatic vagotomy does not suppress high protein diet-induced food intake depression in rats.
This study was undertaken to determine whether the subdiaphragmatic vagus nerve is involved in the depression of food intake induced by the ingestion of a high protein diet (P50) in rats. After total subdiaphragmatic vagotomy (Vago group) or sham surgery (Sham group), rats consumed the control diet for a 2-wk recovery period and then both groups consumed the high protein diet for 16 d. Daily food intake, meal pattern analysis and behavioral satiety sequence were measured. Total subdiaphragmatic vagotomy did not modify the daily intake of the control diet or suppress the dramatic depression in food intake produced by acute transition to a high protein diet. However, the daily intake of a high protein diet was slightly reduced under acute conditions or even after adaptation (P < 0.005). Analysis of meal parameters and the behavioral satiety sequence after adaptation indicated no major metabolic distress. In conclusion, these results suggest that the subdiaphragmatic vagus nerve does not constitute an obligatory pathway for the transfer of information to the brain, resulting in a depression of high protein diet intake. In contrast, a defect in this visceral regulating system could reinforce the metabolic-associated food intake depression signal.
L'Heureux-Bouron
Diane
D
Unité INRA 914 de Physiologie de la Nutrition et du Comportement Alimentaire, Institut National Agronomique Paris-Grignon, F75231 Paris Cedex 05, France.
Tomé
Daniel
D
Rampin
Olivier
O
Even
Patrick C
PC
Larue-Achagiotis
Christiane
C
Fromentin
Gilles
G
D000818:Animals; D001522:Behavior, Animal; D001835:Body Weight; D004044:Dietary Proteins / Q000008:administration & dosage*; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake; D005247:Feeding Behavior; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012528:Satiety Response; D014628:Vagotomy / Q000379:methods
D004044:Dietary Proteins