Flavonoids and isoflavonoids with antiplasmodial activities from the root bark of Erythrina abyssinica.
From the root bark of Erythrina abyssinica a new pterocarpene [3-hydroxy-9-methoxy-10-(3,3-dimethylallyl)pterocarpene] and a new isoflav-3-ene [7,4'-dihydroxy-2',5'-dimethoxyisoflav-3-ene] were isolated. In addition, the known compounds erycristagallin, licoagrochalcone A, octacosyl ferulate and triacontyl 4-hydroxycinnamate were identified. The structures were determined on the basis of spectroscopic evidence. The crude extract and the flavonoids and isoflavonoids obtained from the roots of this plant showed antiplasmodial activities.
Yenesew
Abiy
A
Department of Chemistry, University of Nairobi, Nairobi, Kenya. ayenesew@uonbi.ac.ke
Derese
Solomon
S
Irungu
Beatrice
B
Midiwo
Jacob O
JO
Waters
Norman C
NC
Liyala
Pamela
P
Akala
Hoseah
H
Heydenreich
Matthias
M
Peter
Martin G
MG
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology; D004895:Erythrina / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D005419:Flavonoids