The penetration of moxifloxacin into the pancreas of male rats in experimental acute necrotizing pancreatitis.
Infectious complications of acute necrotizing pancreatitis (ANP) determine the extent of multiorgan failure and account for 80% of deaths. Prophylactic use of antibiotics can reduce the incidence of these complications. However, the actual indication as well as choice of drug remains a controversial matter. We examined the penetration of moxifloxacin, a new broad-spectrum fluoroquinolone, in healthy and inflamed pancreatic tissue in rats after inducing ANP. The concentration of moxifloxacin in pancreatic tissue and serum was determined 10, 30, 60 and 240 min after the administration of moxifloxacin (5 mg/kg, i.v.). Mean serum concentrations 10 min after administration in rats with ANP were 1,886 ng/ml versus 1,805 ng/ml in healthy controls, and these values decreased to 350 versus 222 ng/ml, respectively, after 240 min. Corresponding concentrations in pancreatic tissue were in the mean 2-3 times higher.
Wacke
Rainer
R
Institute of Clinical Pharmacology, Center of Pharmacology and Toxicology, University of Rostock, Rostock, Germany. rainer.wacke@med.uni-rostock.de
Park
Sora
S
Mundkowski
Ralf G
RG
Block
Norma
N
Kuhn-Thiel
Alexandra
A
Drewelow
Bernd
B
D000818:Animals; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics*; D001372:Aza Compounds; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control; D024841:Fluoroquinolones; D008297:Male; D000077266:Moxifloxacin; D010179:Pancreas / Q000378:metabolism*; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications / Q000378:metabolism*; D011804:Quinolines; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin