[Clinical features of patients associated with anti-GM1b antibody].
To clarify the clinical features of patients with anti-GM1b antibody, we retrospectively investigated which conditions were associated with anti-GM1b antibody in a large number of patients. Two hundred out of 1,713 patients had anti-GM1b antibody. One hundred and sixty-six (83%) were diagnosed with Guillain-Barré syndrome (GBS) or atypical GBS with preserved deep tendon reflexes. Our study suggests that the anti-GM1b antibody testing is useful for supporting the diagnosis of GBS. In addition, anti-GM1b antibody was detected in 18 patients with Fisher syndrome and the related conditions associated with anti-GQ1b IgG antibody, and 3 patients with ataxic GBS associated with anti-GD1b IgG antibody.
Tatsumoto
Muneto
M
Department of Neurology, Dokkyo University School of Medicine.
Yuki
Nobuhiro
N
Odaka
Masaaki
M
Hirata
Koichi
K
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005677:G(M1) Ganglioside / Q000031:analogs & derivatives* / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D019846:Miller Fisher Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D012189:Retrospective Studies
D001323:Autoantibodies; D015415:Biomarkers; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005677:G(M1) Ganglioside; C029624:ganglioside M1b