Bioactive coumarins from the leaves of Murraya omphalocarpa.
Using antiplatelet aggregation as a guide to fractionation, eight coumarins, omphalocarpinol (1), 5,7-dimethoxy-8-(3'-methyl-2'-oxobutyl)coumarin (2), murralongin, murrayanone, omphamurin (5), murragleinin, mexoticin, and murrangatin, were isolated from the leaves of Murraya omphalocarpa. Compound 1 is new, and 5 is a new enantiomer of omphamurin. The structures of these compounds were elucidated on the basis of spectroscopic techniques, and the structure of compound 1 was confirmed by X-ray crystallographic analysis. Among them, compounds 1, 2 and 5 exhibited significant antiplatelet aggregation activity.
Chen
Keh-Shaw
KS
Ta-Jen Pharmaceutical Junior College, Ping Tung Hsien, Taiwan, R.O.C.
Wu
Chin-Chuang
CC
Chang
Fang-Rong
FR
Chia
Yi-Chen
YC
Chiang
Michael-Y
MY
Wang
Wei-Ya
WY
Wu
Yang-Chang
YC
D000818:Animals; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D032101:Murraya / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits
D003374:Coumarins