Control of electron transfer in DNA by peptide nucleic acids (PNA).
The one-electron oxidation of PNA-DNA hybrid containing G-triplet sequence was examined. In DNA duplex G-triplet was selectively cleaved by oxidation, whereas in PNA-DNA hybrid cleavage efficiency was extremely lowered. These result suggested that cleavage efficiency of PNA-DNA hybrid was different from that of B-form DNA duplex.
Tanabe
K
K
Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606-8501, Japan.
Yoshida
K
K
Dohno
C
C
Okamoto
A
A
Saito
I
I
D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004579:Electron Transport; D066298:In Vitro Techniques; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*
D009838:Oligodeoxyribonucleotides; D020135:Peptide Nucleic Acids; D004247:DNA