title: [The frequency distribution of flavin-containing monooxygenase 3 mutant alleles in 28 populations from Yunnan].
abstract: OBJECTIVE
  To study the frequency distribution of flavin-containing monooxygenase 3 (FMO3) mutant alleles in 28 populations originating from 24 ethnic minorities in Yunnan of China.
  
  
  METHODS
  FMO3 genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  The average frequencies of FMO3/Stop(148), FMO3/Lys(158) and FMO3/Gly(308) were 0.395(0.174-0.803), 0.208 (0.056-0.414), 0.046(0-0.217), respectively. The frequencies of FMO3/Gly(308) in Blang, Huayaodai, Shuidai, Zhuang, De'ang, Jingpo, Nu and Hui populations were null.
  
  
  CONCLUSIONS
  It was found that the frequencies of FMO3 mutant alleles varied not only in different ethnic groups, but also in different populations that stemmed from the same ethnic group.
authors.affiliation: Human Genetics Center, Yunnan University, Kunming, Yunnan, 650091 PR China.
authors.forename: Wei-min
authors.initials: WM
authors.lastname: Zeng
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Yong-li
authors.initials: YL
authors.lastname: Dong
authors.forename: Hong
authors.initials: H
authors.lastname: Shi
authors.forename: Lu
authors.initials: L
authors.lastname: Gao
authors.forename: Zhi-li
authors.initials: ZL
authors.lastname: Yang
authors.forename: Jin
authors.initials: J
authors.lastname: Lu
authors.forename: Zhao-jing
authors.initials: ZJ
authors.lastname: Hao
authors.forename: Chun-jie
authors.initials: CJ
authors.lastname: Xiao
mesh_terms: D000483:Alleles; D002681:China; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D009154:Mutation; D010105:Oxygenases / Q000235:genetics*
chemical_list: D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming)