title: Molecular chaperones, stress proteins and redox homeostasis.
abstract: Protection against oxidative stress is highly interrelated with the function of the most ancient cellular defense system, the network of molecular chaperones, heat shock, or stress-proteins. These ubiquitous, conserved proteins help other proteins and macromolecules to fold or re-fold and reach their final, native conformation. Redox regulation of protein folding becomes especially important during the preparation of extracellular proteins to the outside oxidative milieu, which should take place in a gradual and step-by-step controlled manner in the endoplasmic reticulum or in the periplasm. Several chaperones, such as members of the Hsp33 family in yeast and the plethora of small heat shock proteins as well as one of the major chaperones, Hsp70 are able to act against cytoplasmic oxidative damage. Abrupt changes of cellular redox status lead to chaperone induction. The function of several chaperones is tightly regulated by the surrounding redox conditions. Moreover, our recent data suggest that chaperones may act as a central switchboard for the transmission of redox changes in the life of the cell.
authors.affiliation: Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8, Hungary.
authors.forename: Eszter
authors.initials: E
authors.lastname: Papp
authors.forename: Gábor
authors.initials: G
authors.lastname: Nardai
authors.forename: Csaba
authors.initials: C
authors.lastname: Söti
authors.forename: Péter
authors.initials: P
authors.lastname: Csermely
mesh_terms: D000375:Aging; D000818:Animals; D002470:Cell Survival; D003593:Cytoplasm / Q000737:chemistry; D004194:Disease; D004721:Endoplasmic Reticulum / Q000737:chemistry; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D018832:Molecular Chaperones / Q000737:chemistry / Q000502:physiology; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017510:Protein Folding
chemical_list: D006360:Heat-Shock Proteins; D018832:Molecular Chaperones