Silicon-substrate intracortical microelectrode arrays for long-term recording of neuronal spike activity in cerebral cortex.
This study investigated the use of planar, silicon-substrate microelectrodes for chronic unit recording in the cerebral cortex. The 16-channel microelectrodes consisted of four penetrating shanks with four recording sites on each shank. The chronic electrode assembly included an integrated silicon ribbon cable and percutaneous connector. In a consecutive series of six rats, 5/6 (83%) of the implanted microelectrodes recorded neuronal spike activity for more than six weeks, with four of the implants (66%) remaining functional for more than 28 weeks. In each animal, more than 80% of the electrode sites recorded spike activity over sequential recording sessions during the postoperative time period. These results provide a performance baseline to support further electrode system development for intracortical neural implant systems for medical applications.
Kipke
Daryl R
DR
Department of Biomedical Engineering, the University of Michigan, Ann Arbor 48109-2099, USA. dkipke@umich.edu
Vetter
Rio J
RJ
Williams
Justin C
JC
Hetke
Jamille F
JF
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001303:Auditory Cortex / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology*; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods*; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology; D019919:Prosthesis Implantation / Q000379:methods*; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012825:Silicon; D013003:Somatosensory Cortex / Q000502:physiology
D012825:Silicon