title: Inhibitory effects of resveratrol derivatives from dipterocarpaceae plants on tyrosinase activity.
abstract: Stilbene derivatives, which are resveratrol (3,4',5-trihydroxy-trans-stilbene) oligomers ranging from monomer to tetramer, isolated from Dipterocarpaceae plants were tested for their inhibitory effects against murine tyrosinase activity. The structure-activity relationships obtained in this study suggest that the double bond in the stilbene skeleton is critical for the inhibition, and also that molecular size is important for inhibitory potency.
authors.affiliation: Gifu International Institute of Biotechnology, Kakamigahara, Japan. kohguchi@giib.or.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohguchi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ito
authors.forename: Munekazu
authors.initials: M
authors.lastname: Iinuma
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Akao
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nozawa
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D020448:Ericales / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D011753:Pyrones; D013267:Stilbenes; C011890:kojic acid; D014442:Monophenol Monooxygenase; D000077185:Resveratrol