title: [Investigation on tumor-targeting characteristics of bifidobacterium infantis to melanoma in mice].
abstract: OBJECTIVE
  To investigate the tumor-targeting of bifidobacterium infantis to melanoma.
  
  
  METHODS
  After bolus administration of bifidobacterium infantis with 3H-TdR tagged, the values of radioactivity in tumor and organs were examined at days 1, 2, 3, 4 and 7. Anaerobic culture and histological observation of tumor and normal organs were taken for the examination of tumor-targeting characteristics of bifidobacterium infantis.
  
  
  RESULTS
  The radioactivity in melanoma tissue increased progressively, while the radioactivity in normal organs became attenuated with time. The anaerobic culture showed an obvious proliferation of bifidobacterium infantis in tumor tissue. A large part of area was Gram positive in the tumor tissue section, whereas the normal tissue was Gram negative.
  
  
  CONCLUSIONS
  Bifidobacterium infantis has good tumor-targeting characteristics in mice melanoma.
authors.affiliation: Department of Pathophysiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wu
authors.forename: Cheng
authors.initials: C
authors.lastname: Yi
authors.forename: Shuren
authors.initials: S
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001644:Bifidobacterium / Q000254:growth & development / Q000502:physiology*; D005260:Female; D000922:Immunotoxins; D008545:Melanoma / Q000382:microbiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D019042:Muscle Neoplasms / Q000382:microbiology; D009368:Neoplasm Transplantation
chemical_list: D000922:Immunotoxins