Meiosis: polo, FEAR and the art of dividing reductionally.
Recent studies on the regulation of meiosis have uncovered new roles for old acquaintances: the polo-like kinase Cdc5 has been found to dictate proper kinetochore orientation during meiosis I, while the FEAR pathway is essential for some, but not all, aspects of meiosis I exit.
Cohen-Fix
Orna
O
The Laboratory of Cellular and Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA.
D000705:Anaphase / Q000502:physiology*; D018797:Cell Cycle Proteins; D020090:Chromosome Segregation / Q000502:physiology*; D018386:Kinetochores / Q000378:metabolism*; D008540:Meiosis / Q000502:physiology*; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases; D029701:Saccharomyces cerevisiae Proteins
D018797:Cell Cycle Proteins; D029701:Saccharomyces cerevisiae Proteins; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; C081927:CDC5 protein, S cerevisiae