title: Nutritional assessment of demented patients: a descriptive study.
abstract: OBJECTIVE
  It is well-known that subclinical and overt malnutrition are strong predictive indices of morbidity and mortality in old subjects, particularly in demented ones, and may deeply affect the quality of life. The aim of this study was evaluation of nutritional status in demented patients, as a whole and according to type of dementia, at the moment of hospital admission and before discharge.
  
  
  METHODS
  The study concerns 174 old demented patients, aged 80.2 +/- 8 SD, diagnosed as having Alzheimer's disease, vascular dementia, degenerative and vascular dementia, reversible dementia, and other types of dementia. In each subject, anthropometric measures, body composition analysis by the bioelectric impedance technique, Mini Nutritional Assessment (MNA) and cognitive, functional and affective assessment by conventional geriatric instruments were performed. A blood sample allowed assay of the main biochemical nutritional markers. At the end of the hospitalization period, the same cognitive, functional and nutritional assessment was repeated, in order to evaluate the effects of vitamin and protein supplements and of care during meals.
  
  
  RESULTS
  In all subgroups of demented patients, obtained according to type of dementia, the mean MNA score was indicative of risk for malnutrition. Furthermore, the MNA score was significantly related to severe cognitive impairment, functional status, comorbidity, BMI values, and transferrin and total protein serum levels. Malnourished patients and demented elderly at risk for malnutrition (according to the MNA score) were given oral nutritional supplements during hospitalization, lasting a mean of 45 days. Before discharge, these two subtypes of demented patients showed substantial maintenance of their cognitive, functional and nutritional status, whereas the subgroup of well-nourished demented patients exhibited significant worsening of the nutritional pattern.
  
  
  CONCLUSIONS
  Demented patients show a high percentage of malnutrition, particularly evident in subjects with deeper cognitive impairment. Nutritional status seems to be linked more to functional abilities than to duration of disease. However, nutritional intervention or special care during meals may act in synergy with specific pharmacologic therapy of dementia.
authors.affiliation: Department of Internal Medicine and Medical Therapy, Chair of Geriatrics, University of Pavia, Pavia, Italy. flaviamagri@libero.it
authors.forename: Flavia
authors.initials: F
authors.lastname: Magri
authors.forename: Angela
authors.initials: A
authors.lastname: Borza
authors.forename: Stefania
authors.initials: S
authors.lastname: del Vecchio
authors.forename: Spyridon
authors.initials: S
authors.lastname: Chytiris
authors.forename: Giovanni
authors.initials: G
authors.lastname: Cuzzoni
authors.forename: Lorena
authors.initials: L
authors.lastname: Busconi
authors.forename: Anna
authors.initials: A
authors.lastname: Rebesco
authors.forename: Ettore
authors.initials: E
authors.lastname: Ferrari
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003704:Dementia / Q000503:physiopathology*; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D015596:Nutrition Assessment; D009752:Nutritional Status; D012044:Regression Analysis