[Portal vein thrombosis associated with factor V Leiden mutation in a woman who underwent exchange transfusion at birth].
We report the case of a 18-year-old woman with portal vein thrombosis and chronic hepatitis C virus. Portal vein thrombosis was diagnosed by chance on ultrasound examination during initial hepatitis C virus-positive patient screening. The patient interview revealed a history including exchange transfusion at birth, followed by necrotising ulcerocolitis and septicemia. The investigation of general factors favoring thrombosis showed acquired protein S deficiency and heterozygous factor V Leiden mutation. This case demonstrates the value of systematic investigations for general thrombophilic factors in cases of portal vein thrombosis even when a local cause is found.
Tchuenbou
Juliette
J
Service d'Hépato-Gastro-Entérologie, Hôpital Trousseau, CHU Tours, 37044 Tours Cedex.
Bacq
Yannick
Y
Fimbel
Béatrice
B
Metman
Etienne-Henry
EH
D000293:Adolescent; D005078:Exchange Transfusion, Whole Blood; D005165:Factor V; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D017354:Point Mutation; D011169:Portal Vein; D013927:Thrombosis / Q000209:etiology*
C095381:factor V Leiden; D005165:Factor V