ADAM33: a novel therapeutic target for asthma.
The incidence of asthma worldwide is increasing, and the disease has a large unmet clinical need. Despite the availability of anti-inflammatory and bronchodilator medication, there is persisting morbidity and mortality. New approaches are needed to understand the role that structural changes in the airways (remodelling) play in this process. Studies of the genetic basis of asthma have identified the ADAM33 (a disintegrase and metalloproteinase 33) gene, a novel member of the ADAM family of zinc-dependent metalloproteases, as a risk factor for the development of asthma and bronchial hyperresponsiveness (BHR). The identification of ADAM33 as a major risk factor involved in the pathogenesis of BHR and airway wall remodelling provides insight into the pathogenesis of asthma and represents a novel therapeutic target.
Powell
Robert M
RM
r.m.powell@soton.ac.uk
Hamilton
Lynnsey M
LM
Holgate
Stephen T
ST
Davies
Donna E
DE
Holloway
John W
JW
D051722:ADAM Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology / Q000276:immunology; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D016022:Case-Control Studies; D002454:Cell Differentiation; D002455:Cell Division; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics; D015195:Drug Design; D020022:Genetic Predisposition to Disease; D006801:Humans; D008126:Lod Score; D051379:Mice; D005810:Multigene Family; D009130:Muscle, Smooth / Q000201:enzymology; D011480:Protease Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D017434:Protein Structure, Tertiary; D013379:Substrate Specificity
D018927:Anti-Asthmatic Agents; D011480:Protease Inhibitors; D051722:ADAM Proteins; C450441:ADAM33 protein, human