Blockade of reticular formation activity, due to carisoprodol maternal administration, and its effects on rat skeleton development.
The purpose of this experiment was to study the influence of reticular formation blockade, due to carisoprodol maternal administration, on rat skeleton development. The drug was administered three times a day orally by stomach tube at doses: T1--20 mg/kg/24 h, T2--200 mg/kg/24 h, T3--400 mg/kg/24 h. The fetuses obtained on 21st day of gestation were counted and macroscopically examined. Placental and fetal weight, fetal and tail length were checked. After fixation in 95% ethanol the fetuses were stained under single alizarin red S Dawson method and examined under a stereo-dissection microscope. Morphological examination revealed no major malformations. Insignificant number of subcutaneous ecchymose and various skeleton anomalies were observed. The experiment revealed that carisoprodol has no influence on rat skeleton development.
Blicharski
Tomasz
T
Experimental Teratology Unit of Human Anatomy Department, Medical University of Lublin.
Burdan
Franciszek
F
Małkiewicz
Jarosław
J
Piechota
Grzegorz
G
D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D000818:Animals; D001848:Bone Diseases, Developmental / Q000139:chemically induced* / Q000473:pathology; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology; D002328:Carisoprodol / Q000633:toxicity*; D005260:Female; D005865:Gestational Age; D008297:Male; D009125:Muscle Relaxants, Central / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012154:Reticular Formation / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
D009125:Muscle Relaxants, Central; D002328:Carisoprodol