title: Long-term survival in adult mediastinal neuroblastoma.
abstract: Neuroblastoma rarely occurs in adults, in whom prognosis is poor. Here we report on the effective use of multimodal therapy to achieve long-term survival in adult mediastinal neuroblastoma. In a 33-year-old male with severe pain radiating from the left hypochondrium to the back area, no abnormal shadow was detected on first examination; the shadow appeared in chest X-ray only 10 months later when the severe pain recurred. The patient was then referred to our department for further examination. Chest X-rays and chest CT scans revealed a posterior mediastinal mass beside the thoracic vertebrae. Diagnosis was confirmed after surgical resection, which was followed by outpatient adjuvant therapy through radiation and chemotherapy. The patient has survived 8 years and 8 months without recurrence or metastasis.
authors.affiliation: Department of Surgery I, Tokyo Women's Medical University, Tokyo, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Shimizu
authors.forename: Toshihide
authors.initials: T
authors.lastname: Shimizu
authors.forename: Takashi
authors.initials: T
authors.lastname: Adachi
authors.forename: Masaki
authors.initials: M
authors.lastname: Nishiuchi
authors.forename: Masato
authors.initials: M
authors.lastname: Kanzaki
authors.forename: Takamasa
authors.initials: T
authors.lastname: Onuki
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000401:mortality* / Q000628:therapy; D009447:Neuroblastoma / Q000401:mortality* / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D016019:Survival Analysis; D013908:Thoracotomy; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D003520:Cyclophosphamide