title: Replacement of the aortic valve after the arterial switch operation.
abstract: An 11-month-old infant had undergone a primary arterial switch operation, including the Lecompte maneuver, for correction of discordant ventriculo-arterial connections and closure of an accompanying ventricular septal defect. At discharge, there were no signs of aortic valvar incompetence. Regurgitation across the aortic valve was detected first at the age of 2 years, and then increased progressively, as documented by serial echocardiographic studies. There had been no history of bacterial endocarditis. At the age of 10 years, echocardiography revealed severe aortic valvar incompetence. At operation, the aortic valve had three leaflets, all of which were short, with very restricted movement. Absence of sufficient leaflet tissue precluded a durable valvar reconstruction, so the aortic valve was replaced with a 21 mm mechanical prosthesis. Histological examination of the removed leaflets revealed nodular swelling due to mucous changes of the matrix, as well as fibrous alteration and formation of scar tissue, including areas of fibroblastic and capillary proliferation. There were no signs of calcification or acute inflammatory changes. Improvement of left ventricular function was observed both early postoperatively and later on. Our observation shows that aortic valvar incompetence after an arterial switch operation can be caused by degenerative changes of the neo-aortic leaflets, which prevent plastic reconstruction of the valve, necessitating valvar replacement.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Deutsches Herzzentrum, Berlin, Germany. alexi@dhzb.de
authors.forename: Vladimir
authors.initials: V
authors.lastname: Alexi-Meskishvili
authors.forename: Joachim
authors.initials: J
authors.lastname: Photiadis
authors.forename: Jan-Hendrik
authors.initials: JH
authors.lastname: Nürnberg
mesh_terms: D001021:Aortic Valve / Q000637:transplantation*; D001022:Aortic Valve Insufficiency; D002648:Child; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D014188:Transposition of Great Vessels / Q000601:surgery*