Microvascular damage following experimental sinus-vein thrombosis in rats.
We evaluated effects of thrombosis of the superior sagittal sinus, its bridging and cortical veins (SVT) on the cerebral microvasculature in rats. Cryosections of brains ( n=7) were examined for venous infarction and microvascular basal lamina damage 3 h after SVT by immunohistochemical staining of microtubule-associated protein 2 and collagen type IV. Microvessels in the infarctions showed a decrease in the number (23.5+/-6.1%, P<0.002) and the total area (24.9+/-6.5%, P<0.011) of collagen type IV-positive vessels in contrast to control areas (21.7+/-12.4%, P<0.007; and 26.3+/-15.1%, P<0.026 in contrast to control areas of unoperated animals). This study showed a significant alteration of the cerebral microvasculature in SVT, which might contribute to edema and hemorrhagic transformation.
Vosko
M R
MR
Department of Neurology, Klinikum Grosshadern, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.
Röther
J
J
Friedl
B
B
Bültemeier
G
G
Kloss
C U A
CU
Hamann
G F
GF
D000818:Animals; D002452:Cell Count; D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000378:metabolism; D024141:Collagen Type IV / Q000378:metabolism; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D008297:Male; D008833:Microcirculation / Q000378:metabolism / Q000473:pathology; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012851:Sinus Thrombosis, Intracranial / Q000150:complications* / Q000378:metabolism; D018709:Statistics, Nonparametric; D020246:Venous Thrombosis / Q000150:complications* / Q000378:metabolism
D024141:Collagen Type IV; D008869:Microtubule-Associated Proteins