title: Zyban-- is there a cause for concern?
abstract: Bupropion hydrochloride is a monocyclic antidepressant which is used in a slow-release formulation as a smoking cessation aid. Its side effects include insomnia and dry mouth with seizures occurring in 1 in 1000 patients. In overdose, it can cause tachycardia, conduction defects and convulsions. It is, however, effective in smoking cessation in approximately 20% of patients and may be more effective if combined with nicotine replacement therapy. The key question is whether the risks associated with the drug are justified by the obvious benefits to health from smoking cessation.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Tracey
mesh_terms: D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D019540:Area Under Curve; D016642:Bupropion / Q000009:adverse effects / Q000627:therapeutic use; D062787:Drug Overdose; D006207:Half-Life; D006801:Humans; D012640:Seizures / Q000139:chemically induced*; D016540:Smoking Cessation; D014018:Tissue Distribution
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion