title: Synthesis of 2'-O-deuteriomethyl ribonucleosides Gm-d3, Am-d3, Um-d3 and Cm-d3.
abstract: The synthesis of 2'-O-deuteriomethyl ribonucleosides by iodomethane-d3 (99.5 + atom % D) deuteriomethylation of 3',5'-O-tetra(isopropyldisiloxane)-diyl nucleosides, followed by deprotection, is described.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, 30 S 2000 E, Salt Lake City, UT 84112, USA.
authors.forename: T
authors.initials: T
authors.lastname: Hashizume
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003903:Deuterium / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D012313:RNA / Q000138:chemical synthesis / Q000737:chemistry; D020871:RNA Stability; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D012263:Ribonucleosides; D012313:RNA; D003903:Deuterium