title: Synthesis of 4'-ethynyl-purine nucleosides possessing anti-HIV activity.
abstract: Searching for more effective anti-HIV agents, we have prepared 4'-ethynyl-purine nucleosides. They were derived in several steps from 4-C-triethylsilylethynyl ribose, which was used as an intermediate in the synthesis of pyrimidine nucleosides. The adenine derivative exhibited significant anti-HIV activity and favorable cytotoxicity profile in vitro.
authors.affiliation: Biochemicals Division, Yamasa Corporation, 2-10-1 Araoicho, Choshi, Chiba 288-0056, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kitano
authors.forename: S
authors.initials: S
authors.lastname: Sakata
authors.forename: S
authors.initials: S
authors.lastname: Kohgo
authors.forename: M
authors.initials: M
authors.lastname: Matsuoka
authors.forename: E
authors.initials: E
authors.lastname: Kodama
authors.forename: H
authors.initials: H
authors.lastname: Mitsuya
authors.forename: H
authors.initials: H
authors.lastname: Ohrui
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D015195:Drug Design; D006678:HIV / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008722:Methods; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D011684:Purine Nucleosides