Secretory granules: and the last shall be first...
By tagging secretory granules with the fluorescent protein dsRed-E5, which changes its emission from green to red over time, Duncan et al. analysed the age-dependent distribution of secretory vesicles within chromaffin cells. This elegant study illustrates as never before how age is a critical factor that segregates granules with respect to their localization and mobility and the probability of them undergoing exocytosis in response to different stimuli.
Solimena
Michele
M
Experimental Diabetology, Carl Gustav Carus Medical School, University of Technology-Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. michele.solimena@mailbox.tu-dresden.de
Gerdes
Hans Hermann
HH
D000818:Animals; D002417:Cattle; D019439:Chromaffin Cells / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology; D005089:Exocytosis / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D008164:Luminescent Proteins / Q000032:analysis / Q000378:metabolism; D008561:Membrane Fusion / Q000502:physiology; D008856:Microscopy, Fluorescence / Q000379:methods; D008954:Models, Biological; D022142:Secretory Vesicles / Q000502:physiology*; D013997:Time Factors; D000097573:Red Fluorescent Protein
D019204:GTP-Binding Proteins; D008164:Luminescent Proteins; D000097573:Red Fluorescent Protein