Free radical scavenging activity of the alcoholic extract of Trewia polycarpa roots in arthritic rats.
The alcoholic extract of Trewia polycarpa roots (TPE), which exhibited significant anti-inflammatory activity, was evaluated for the possible mode of action by studying its antioxidant potential in adjuvant-induced arthritic rats. The biological defence system constituting the superoxide dismutase, glutathione peroxidase, ascorbic acid showed a significant increase while the lipid peroxide content was found to decrease to a large extent on TPE treatment thereby indicating the extracts free radical scavenging property. Histopathological studies too supported anti-arthritic potential of the roots of Trewia polycarpa.
Chamundeeswari
D
D
Sri Ramachandra Medical College and Research Institute, Porur, 600 116 Chennai, India.
Vasantha
J
J
Gopalakrishnan
S
S
Sukumar
E
E
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D001205:Ascorbic Acid / Q000097:blood / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D004487:Edema / Q000188:drug therapy; D000431:Ethanol; D019665:Euphorbiaceae; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005620:Freund's Adjuvant / Q000009:adverse effects; D005978:Glutathione / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000187:drug effects / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D008515:Medicine, Ayurvedic; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry*; D051381:Rats; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism; D013582:Synovial Fluid / Q000737:chemistry / Q000166:cytology / Q000187:drug effects; D018675:Toxicity Tests
D000893:Anti-Inflammatory Agents; D016166:Free Radical Scavengers; D010936:Plant Extracts; D000431:Ethanol; D005620:Freund's Adjuvant; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D001205:Ascorbic Acid; D007213:Indomethacin