A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis.
1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3) inhibits the expression of an immediate-early gene, IEX-1, which is involved in the regulation of cellular growth and apoptosis in a variety of cells. 1alpha,25(OH)2D3 alters the subcellular localization of IEX-1 by causing an efflux of IEX-1 from the nucleus, and the sterol decreases the expression of IEX-1 messenger RNA in cells via a novel DR3 repeat-type DNA response element.
Kumar
Rajiv
R
Department of Medicine, Mayo Clinic and Foundation, 911A Guggenheim Building, 200 First Street S.W., Rochester, MN 55905, USA. rkumar@mayo.edu
Pittelkow
Mark R
MR
Salisbury
Jeffrey L
JL
Grande
Joseph P
JP
Im
Hee-Jeong
HJ
Feldmann
Kathrin A
KA
Schilling
David
D
D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D002117:Calcitriol / Q000494:pharmacology*; D002455:Cell Division; D002467:Cell Nucleus / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D021381:Protein Transport; D020218:Response Elements / Q000235:genetics; D014158:Transcription, Genetic
D051017:Apoptosis Regulatory Proteins; C099815:IER3 protein, human; D017874:Immediate-Early Proteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D002117:Calcitriol