Solution structure of the DNA complex with a quinacrine-netropsin hybrid molecule by NMR spectroscopy.
The solution structures of 1:1 complexes of a quinacrine-netropsin hybrid molecule with the self-complementary DNA duplexes, d(CGCGAATTCGCG)2 and d(CGAATTCG)2, have been studied by one- and two-dimensional 1H NMR spectroscopy. The NOE data indicate that the acridine ring of the hybrid intercalates into the 5'-GpA step and its netropsin moiety spans the minor groove of the central AATT region.
Kubota
Y
Y
Department of Chemistry, Faculty of Science, Yamaguchi University, Yamaguchi 753-8512, Japan.
Tani
S
S
Uchida
R
R
D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry*; D015394:Molecular Structure; D009429:Netropsin / Q000031:analogs & derivatives* / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D011522:Protons; D011796:Quinacrine / Q000031:analogs & derivatives* / Q000737:chemistry; D012996:Solutions
D007364:Intercalating Agents; D009838:Oligodeoxyribonucleotides; D011522:Protons; D012996:Solutions; D009429:Netropsin; D004247:DNA; D011796:Quinacrine