Immunocytochemical examinations of hippocampal nerve cells after experimental administration of dexamethasone.
The purpose of this research was an assessment of MAP2 immunoreactivity in hippocampal neurons after administration of toxic doses of dexamethasone. Experiments were led on Albino-Swiss mouse males. The obtained results indicate that dexamethasone causes significant decrease of MAP2 immunoreactivity in hippocampal nerve cells of the CA3 region. Our results show damage of neuronal cytoskeleton in this area of the brain.
Sekita-Krzak
Joanna
J
Department of Histology and Embryology with the Lab of Experimental Cytology, Department of Clinical Pharmacology, Medical University of Lublin.
Czerny
Krystyna
K
Zebrowska-Łupina
Iwona
I
Stepniewska
Maria
M
Visconti
Józef
J
Pedrycz-Wieczorska
Agnieszka
A
D000818:Animals; D003907:Dexamethasone / Q000008:administration & dosage* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D009410:Nerve Degeneration / Q000139:chemically induced* / Q000378:metabolism* / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D017966:Pyramidal Cells / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D012016:Reference Values
D008869:Microtubule-Associated Proteins; D018696:Neuroprotective Agents; D003907:Dexamethasone