title: [Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios].
abstract: OBJECTIVE
  To investigate the relationship between two polymorphisms (Intronic VNTR and 5-HTTLPR) of the serotonin transporter gene and schizophrenia.
  
  
  METHODS
  A set of 314 schizophrenic trio samples collected from Shanghai, Xi'an and Jilin regions of China independently was subjected to analysis of the polymorphisms by transmission/disequilibrium test(TDT).
  
  
  RESULTS
  No significantly preferential transmission of any allele was detected from both polymorphisms investigated.
  
  
  CONCLUSIONS
  The results suggest that the serotonin transporter gene is unlikely to have a major contribution to susceptibility to schizophrenia in Han Chinese population.
authors.affiliation: Bio-X Life Science Research Center, Shanghai Jiaotong University, Shanghai, 200030 PR China.
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Sun
authors.forename: Jin-bo
authors.initials: JB
authors.lastname: Fan
authors.forename: Xue-qing
authors.initials: XQ
authors.lastname: Qian
authors.forename: Jun-xia
authors.initials: JX
authors.lastname: Tang
authors.forename: Yang-lin
authors.initials: YL
authors.lastname: Xing
authors.forename: Jian-guo
authors.initials: JG
authors.lastname: Shi
authors.forename: Shao-min
authors.initials: SM
authors.lastname: Zhu
authors.forename: Hui-jun
authors.initials: HJ
authors.lastname: Liu
authors.forename: Niu-fan
authors.initials: NF
authors.lastname: Gu
authors.forename: Guo-yin
authors.initials: GY
authors.lastname: Feng
authors.forename: Lin
authors.initials: L
authors.lastname: He
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics; D009679:Nuclear Family; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins