title: HLA-DPB1 alleles association of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus.
abstract: Our objective was to determine the HLA-DPB1 allele associations of anticardiolipin (aCL) and anti-beta2GPI (a(beta)2GPI) antibodies, and of clinical manifestations of the antiphospholipid syndrome (APS), in systemic lupus erythematosus (SLE). We studied 577 European patients with SLE. aCL and a(beta)2GPI antibodies were measured by ELISA. Molecular typing of HLA-DPB1 locus was performed by polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) method. aCL showed positive association with -DPB1*1501 (P = 0.005, OR = 7.4), and -DPB1*2301 (P = 0.009, OR = 3.3). a(beta)2GPI showed positive association with -DPB1*0301 (P = 0.01, OR = 1.9), and -DPB1*1901 (P = 0.004, OR = 8.1). In addition, livedo reticularis was associated with -DPB1*1401, and Raynaud's phenomenon with -DPB1*2001. In conclusion, HLA-DPB1 locus may contribute to the genetic predisposition to develop antiphospholipid antibodies and clinical manifestations of the APS in patients with SLE.
authors.affiliation: UO Complessa di Reumatologia, Azienda Ospedaliera San Camillo-Forlanini, Roma, Italy. gsebastiani@scamilloforlanini.rm.it
authors.forename: G D
authors.initials: GD
authors.lastname: Sebastiani
authors.forename: M
authors.initials: M
authors.lastname: Galeazzi
authors.forename: A
authors.initials: A
authors.lastname: Tincani
authors.forename: R
authors.initials: R
authors.lastname: Scorza
authors.forename: A
authors.initials: A
authors.lastname: Mathieu
authors.forename: G
authors.initials: G
authors.lastname: Passiu
authors.forename: G
authors.initials: G
authors.lastname: Morozzi
authors.forename: J C
authors.initials: JC
authors.lastname: Piette
authors.forename: R
authors.initials: R
authors.lastname: Cervera
authors.forename: F
authors.initials: F
authors.lastname: Houssiau
authors.forename: J
authors.initials: J
authors.lastname: Smolen
authors.forename: A
authors.initials: A
authors.lastname: Fernandez Nebro
authors.forename: E
authors.initials: E
authors.lastname: De Ramon
authors.forename: A Jedryka
authors.initials: AJ
authors.lastname: Goral
authors.forename: C
authors.initials: C
authors.lastname: Papasteriades
authors.forename: G B
authors.initials: GB
authors.lastname: Ferrara
authors.forename: C
authors.initials: C
authors.lastname: Carcassi
authors.forename: F
authors.initials: F
authors.lastname: Bellisai
authors.forename: R
authors.initials: R
authors.lastname: Marcolongo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D016736:Antiphospholipid Syndrome / Q000235:genetics / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D020022:Genetic Predisposition to Disease; D006023:Glycoproteins / Q000276:immunology*; D006682:HLA-DP Antigens / Q000032:analysis*; D059868:HLA-DP beta-Chains; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D053482:beta 2-Glycoprotein I
chemical_list: D017153:Antibodies, Anticardiolipin; D001323:Autoantibodies; D006023:Glycoproteins; D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; D053482:beta 2-Glycoprotein I