title: Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children.
abstract: Endothelial lipase (EL) is a new member of the triglyceride lipase family, the genes of which play a central role in dietary fat absorption, energy homeostasis, and plasma lipoprotein metabolism. One physiologic role of EL is thought to be hydrolysis of high-density lipoprotein (HDL) phospholipid, although the precise function of endothelial lipase has yet to be fully clarified. Furthermore, genetic variation in EL has been suggested to influence serum HDL-C levels. In the present study, we detected two common single nucleotide polymorphisms in the EL gene associated with serum HDL cholesterol levels in healthy school-aged children. Our data support the hypothesis that variations in the EL gene are one of the genetic determinants of serum HDL-C levels.
authors.affiliation: Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, 305-8575, Tsukuba, Japan. kobayasi@u-shizuoka-ken.ac.jp
authors.forename: Kimiko
authors.initials: K
authors.lastname: Yamakawa-Kobayashi
authors.forename: Hisako
authors.initials: H
authors.lastname: Yanagi
authors.forename: Kazue
authors.initials: K
authors.lastname: Endo
authors.forename: Tadao
authors.initials: T
authors.lastname: Arinami
authors.forename: Hideo
authors.initials: H
authors.lastname: Hamaguchi
mesh_terms: D000293:Adolescent; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood* / Q000235:genetics; D005260:Female; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D008049:Lipase / Q000235:genetics* / Q000378:metabolism; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D008076:Cholesterol, HDL; C410382:LIPG protein, human; D008049:Lipase