Rapid microwave promoted Sonogashira coupling reactions on solid phase.
A microwave-enhanced, rapid, and efficient solid-phase version of the Sonogashira reaction is presented. It has been applied to the coupling of aryl iodides and bromides with various acetylene derivatives giving excellent yields in 15-25 min. The scopes of homogeneous, solventless, and solid-phase conditions for Sonogashira coupling of aryl halides are compared.
Erdélyi
Máté
M
Department of Organic Chemistry, Uppsala University, Box 599, 751 24 Uppsala, Sweden.
Gogoll
Adolf
A