Photodynamic inhibition of infection caused by drug-resistant variants of herpes simplex virus type I.
Membranotropic amphiphilic chromophore merocyanine 540 sensitized photodynamic inhibition of drug-resistant and sensitive variants of type I herpes simplex virus in cultured Vero cell. Optimal conditions of photodamage to virus particles and infected cells were determined (merocyanine 540 concentration 1 microM, illumination dose 32.5-65.0 kJ/m(2), exposure at early stages of infection). Infected cells actively bind the photosensitizer, which explains their selective photodamage.
Kvacheva
Z B
ZB
State Institute of Epidemiology and Microbiology, Ministry of Health of Belarus Republic, Minsk.
Shukanova
N A
NA
Votyakov
V I
VI
Lobanok
E S
ES
Vorobei
A V
AV
Nikolaeva
S N
SN
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002522:Chlorocebus aethiops; D024882:Drug Resistance, Viral; D006561:Herpes Simplex; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011744:Pyrimidinones / Q000494:pharmacology*; D014709:Vero Cells; D014779:Virus Replication
D000998:Antiviral Agents; D017319:Photosensitizing Agents; D011744:Pyrimidinones; C003954:merocyanine dye