[The effects of sodium nitroprusside-induced hypotension at different levels on cerebral blood flow and metabolism: a clinical study].
OBJECTIVE
The clinical experiment was designed for observing the effects of deliberate hypotension at different level on cerebral blood flow and metabolism.


METHODS
30 ASA Grade I-II patients were randomly allocated to one of three groups (each group n = 10). Hypotension was induced by sodium nitroprusside in group 1[mean arterial pressure (MAP) = 55 mmHg] and group 2 (MAP = 65 mmHg). Group 3 (control) was on normotension. The changes of cerebral blood flow during hypotension were estimated according to the variability of cerebral blood flow velocity (CBFV) in the middle cerebral artery(MCA), which was obtained through transcranial Doppler ultrasonography (TCD).


RESULTS
Hypotension caused a moderate decrease in CBFV, but no significant difference, in CBFV and oxygen saturation in internal jugular vein(SjO2), either among three groups or during the procedure.


CONCLUSIONS
It is safe for cerebral perfusion and metabolism with deliberate hypotension at MAP = 55 mmHg.
Xu
Z
Z
Department of Anesthesiology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China. xuzhongh@263.net
Ren
H
H
Huang
Y
Y
Zhang
X
X
Luo
A
A
Ye
T
T
D000959:Antihypertensive Agents / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006801:Humans; D007023:Hypotension, Controlled / Q000379:methods*; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D009599:Nitroprusside / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D017585:Ultrasonography, Doppler, Transcranial
D000959:Antihypertensive Agents; D009599:Nitroprusside