title: Signal transduction via MHC class I molecules in endothelial and smooth muscle cells.
abstract: MHC class I molecules have long been recognized for their ability to stimulate intracellular signals in T and B lymphocytes. More recently, it has become clear that MHC class I molecules can also initiate intracellular signals in endothelial and smooth muscle cells, which synergize with growth factor receptors to elicit cell proliferation. This review describes our current knowledge of class I-mediated signaling pathways in human endothelial and smooth muscle cells. The role of the class I signaling pathway in modulating cell growth and the clinical significance of this pathway in chronic allograft rejection are discussed.
authors.affiliation: UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. ereed@mednet.ucla.edu
authors.forename: Elaine F
authors.initials: EF
authors.lastname: Reed
mesh_terms: D000818:Animals; D016923:Cell Death / Q000276:immunology; D002455:Cell Division / Q000276:immunology; D042783:Endothelial Cells / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D032389:Myocytes, Smooth Muscle / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D015395:Histocompatibility Antigens Class I