title: Synchronization of ventricular fibrillation with real-time feedback pacing: implication to low-energy defibrillation.
abstract: Wavefront synchronization is an important aspect preceding the termination of ventricular fibrillation (VF). We evaluated the defibrillation efficacy of a novel multisite pacing algorithm using optical recording-guided synchronized pacing (SyncP) in the excitable gaps. We compared the effects of SyncP with traditional overdrive pacing (ODP) at 90% of the VF cycle length (VFCL) and high-frequency pacing (HFP; 43-215 Hz) on spontaneous VF termination in isolated rabbit hearts. For SyncP, the pacing current was triggered by the activation of a reference site and was delivered when the optical potential of the pacing site was in an excitable gap. We measured VFCL and the spatial dispersion of VFCL (SDCL) from five points (3 points in the paced area and 2 points in the nonpaced area) and the distribution of phase singularities during the prepacing, pacing, and postpacing periods. The results showed that 1) the VF termination rate of SyncP (16.0%, n = 106) was higher than that of ODP (2.1%, n = 48, P < 0.01) or HFP (1.6%, n = 129, P < 0.0001); 2) energy consumption for SyncP (7.6 +/- 9.3 mJ) was significantly lower than that of ODP (14.0 +/- 14.8 mJ, P < 0.0001); and 3) SyncP, but not ODP or HFP, decreased SDCL in the paced area during the pacing (P < 0.01) and postpacing (P < 0.05) periods compared with the prepacing period. We conclude that SyncP is effective in inducing wavefront synchronization and is more effective at facilitating spontaneous VF termination than non-SyncP.
authors.affiliation: Department of Medicine, Cedars-Sinai Medical Center and David Geffen School of Medicine, University of California, Los Angeles, 90048, USA.
authors.forename: Hui-Nam
authors.initials: HN
authors.lastname: Pak
authors.forename: Yen-Bin
authors.initials: YB
authors.lastname: Liu
authors.forename: Hideki
authors.initials: H
authors.lastname: Hayashi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okuyama
authors.forename: Peng-Sheng
authors.initials: PS
authors.lastname: Chen
authors.forename: Shien-Fong
authors.initials: SF
authors.lastname: Lin
mesh_terms: D000465:Algorithms; D000818:Animals; D004554:Electric Countershock / Q000379:methods*; D005246:Feedback; D010138:Pacemaker, Artificial; D011817:Rabbits; D014693:Ventricular Fibrillation / Q000503:physiopathology* / Q000628:therapy*