Molecular dynamics investigation of the double stranded oligonucleotide d(AT)6d(AT)6.
Molecular dynamics simulation of double stranded 12-meric oligonucleotide carrying an A and T alternating sequence, d(AT)6d(AT)6, over 1 ns was carried out under low NaCl conditions by using AMBER 6. It was found that the d(AT)6d(AT)6 was stabilized in the D-type structure which is an intermediate structure between A- and B-type ones and this result was in agreement with the previous report.
Fujii
Satoshi
S
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
Okimoto
Noriaki
N
Ebisuzaki
Toshikazu
T
Nojima
Takahiko
T
Takagi
Makoto
M
Takenaka
Shigeori
S
D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*
D009841:Oligonucleotides