title: Synthesis and properties of 5'-amino-2',4'-BNA modified oligonucleotides with P3'-->N5' phosphoramidate linkages.
abstract: 5'-Amino-2',4'-BNA, a novel analogue of BNA series compounds, was synthesized and its incorporation into oligonucleosides via P3'-->N5' phosphoramidate linkage was successfully achieved on a DNA automatic synthesizer. The 5'-amino-2',4'-BNA modified oligonucleotides were found to have a potent hybridizing affinity for the single stranded RNA and double stranded DNA complements, and also to show a good resistant ability against SVPDE.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Obika
authors.forename: Osamu
authors.initials: O
authors.lastname: Nakagawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Hiroto
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hari
authors.forename: Takeshi
authors.initials: T
authors.lastname: Imanishi
mesh_terms: D000577:Amides / Q000737:chemistry*; D001483:Base Sequence; D009696:Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry; D010756:Phosphoric Acids / Q000737:chemistry*
chemical_list: D000577:Amides; D009696:Nucleic Acids; D009841:Oligonucleotides; D010756:Phosphoric Acids; C011067:phosphoramidic acid