Cardiac troponin-I in the serum of infants of diabetic mothers.
A transient form of hypertrophic cardiomyopathy has been previously described in infants of diabetic mothers. When it occurs, it is generally benign. The purpose of our study was to establish the extent of injury to the cardiomyocytes in symptomatic and asymptomatic patients with and without hypertrophic cardiomyopathy. Thus, we compared 35 consecutive patients to 20 healthy controls, establishing the significance, if any, of differences in cardiac troponin-I and creatine kinase, including its MB-fraction, and seeking to establish the value of these parameters in the diagnosis of cardiac injury. We also determined to levels of glucose and insulin in the serum, and took note of electrocardiographic and echocardiographic investigations. Values were determined at the 1st and 7th days after admission in the patients, while parameters were measured in the control group only on the first day. We found that the levels of cardiac troponin-I in the serum, known to be a marker for cardiac injury, were significantly elevated in symptomatic patients with life-threatening respiratory or haemodynamic distress. We speculate that transient ventricular hypertrophy is neither the cause nor the consequence of damage to the cardiomyocytes. It would be interesting, nonetheless, to determine the relationship, if any, between cardiomyocytic damage and clinical outcome.
Oran
Bülent
B
Department of Paediatrics, Meram Medicine Faculty, Selçuk University, Turkey. pedkar@selcuk.edu.tr
Cam
Lokman
L
Başpinar
Osman
O
Baysal
Tamer
T
Reisli
Ismail
I
Peru
Harun
H
Karaaslan
Sevim
S
Koç
Hasan
H
Gürbilek
Mehmet
M
D002312:Cardiomyopathy, Hypertrophic / Q000097:blood* / Q000628:therapy; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007527:Isoenzymes / Q000097:blood; D008297:Male; D032383:Myocytes, Cardiac / Q000473:pathology; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D019210:Troponin I / Q000097:blood*
D007527:Isoenzymes; D019210:Troponin I; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form