A randomized prospective trial of bowel preparation for colonoscopy with Fortrans compared with bisacodyl.
BACKGROUND
An empty and adequate clean colon is a prerequisite of diagnostic or therapeutic colonoscopy. Our aim is to assess the efficacy and tolerance of bowel preparation for colonoscopy with Fortrans (polyethylene glycols) versus oral bisacodyl.


METHODS
One hundred and four consecutive patients scheduled for colonoscopy were prospectively enrolled and allocated to Fortrans group or bisacodyl group by block randomization.


RESULTS
Ninety-four patients were included for final analysis. Forty-five patients underwent preparation with Fortrans. The efficacy and tolerance of colon preparation were similar with both methods (p = 0.102, p = 0.202). The latency before the first bowel movement and total preparation time were shorter with Fortrans than with bisacodyl (p = 0.0001 and 0.001, respectively). Statistically significant differences were noted in changes of body weight, serum levels of sodium and calcium in patients taking bisacodyl (p = 0.049, 0.015, and 0.038, respectively). The taste of Fortrans was rated significantly better than that of bisacodyl (p = 0.002). Patients experienced more abdominal discomfort completing preparation with bisacodyl (p = 0.002).


CONCLUSIONS
Fortrans and bisacodyl are equally effective and well tolerated in preparation for colonoscopy. However, Fortrans preparation takes less time and provides a better taste with less abdominal discomfort and less change in body weight as well as serum levels of sodium and calcium than bisacodyl preparation.
Wang
Huann-Sheng
HS
Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. hswang@vghtpe.gov.tw
Lin
Jen-Kou
JK
D001726:Bisacodyl / Q000008:administration & dosage* / Q000009:adverse effects; D001835:Body Weight; D003113:Colonoscopy / Q000379:methods*; D006801:Humans; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies
D001726:Bisacodyl; D011092:Polyethylene Glycols