[Niclosamide In The Treatment Of Tetagonimiasis]
Anthelmintic effect of niclosamide [N-(2-chloro-4-nitrophenyl)-5-chloro-salicylamide)] on Metagonimus infection was carried out to the cases in area of Seomjin-river. The drug, one tablet contains 0.5 g of niclosamide was supplied from Bu-gwang pharmaceutical company in Seoul. Sixty five cases were divided into three groups by the regimen: Group l given 2 g(4 tablets) for one day, Group II for two successive days and Group III for three successive days. Stool examination was done before and 2-3 weeks after the drug administration by formalin-ether concentration and Stoll's dilution egg counting techniques. The results were as follows: Egg negative conversion (cured) and egg reduction (more than 80% decrease) rates were 28.6%, 10.7% in group I, and 31.8%, 27.3% in group II. But of those in group III treated for three successive days, 73.3% was cured and 26.7% showed egg reduction, and the general egg reduction rate was 95.1%. The results in the present trial suggested that the niclosamide has anthelmintic efficacy when it is used in 2g for more than three successive days.
Ahn
Yung Kyum
YK
Department of Parasitology, College of Medicine and Institute of Tropical Medicine, Yonsei University, Korea.
Chung
Bong Suck
BS
Soh
Chin Thack
CT