The effect of treatment on endothelin-1 concentration and mean arterial pressure in preeclampsia and eclampsia.
OBJECTIVE
The aim of this study was to determine the effect of treatment on endotelin-1 concentration that is considered to have role in etiopathogenesis of eclampsia and preeclampsia.


METHODS
Nine patients with eclampsia and 12 patients with preeclampsia were included to the study. Endothelin-1 levels were measured before and after magnesium sulfate treatment. After the magnesium sulfate administration, if the blood pressure was still elevated, nifedipine was given.


RESULTS
Endothelin-1 levels of preeclamptic patients before and after magnesium sulfate treatment were 16.9 +/- 2.3 fmol/ml and 14.6 +/- 1.9 fmol/ml respectively (p < 0.05). The same measurements of eclamptic patients were 18.1 +/- 3.2 and 14.7 +/- 3.4 respectively (p < 0.05). The mean blood pressures of preeclamptic patients before and after magnesium sulfate were 125.8 +/- 7.3 mm-Hg, 118.2 +/- 8.7 mm-Hg respectively, and the same measurements of eclamptic patients were 136.0 +/- 12.4 mm-Hg and 123.1 +/- 10.6 mm-Hg respectively (p < 0.05, p < 0.05).


CONCLUSIONS
Treatment had been found to have negative effects on endothelin-1 levels that is considered to play an important role on etiopathogenesis of eclampsia and preeclampsia.
Sağsöz
Nevin
N
Kirikkale University, Faculty of Medicine, Department of Obstetrics and Gynecology, Turkey. nsagsoz@isbank.net.tr
Küçüközkan
Tuncay
T
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination; D004461:Eclampsia / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D019332:Endothelin-1 / Q000032:analysis* / Q000187:drug effects*; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D011247:Pregnancy; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D011336:Probability; D011446:Prospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
D015415:Biomarkers; D019332:Endothelin-1; D008278:Magnesium Sulfate