title: Modeling of a possible evolutional process from a ribozyme to a catalytic RNP.
abstract: A model process for molecular evolution from an RNA enzyme to a catalytic RNA-protein complex (RNP) is proposed. In the model, one RNA-RNA interaction in the enzyme is replaced by an RNA-protein interaction via an intermediary state where the original RNA-RNA and newly introduced RNA-protein interaction co-exist. To test the model, a catalytic RNP was designed and examined by employing the Tetrahymena ribozyme.
authors.affiliation: Graduate School of Biostudies, Kyoto University, Kyoto, 606-8502, Japan.
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Ikawa
authors.forename: Kentaro
authors.initials: K
authors.lastname: Tsuda
authors.forename: Shigeyoshi
authors.initials: S
authors.lastname: Matsumura
authors.forename: Shota
authors.initials: S
authors.lastname: Atsumi
authors.forename: Tan
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000818:Animals; D002384:Catalysis; D019143:Evolution, Molecular; D016337:RNA, Catalytic / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D012261:Ribonucleoproteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D013768:Tetrahymena / Q000201:enzymology
chemical_list: D016337:RNA, Catalytic; D012261:Ribonucleoproteins