Overexpression of S100A4 is closely related to the aggressiveness of gastric cancer.
Elevated levels of the calcium-binding protein S100A4 cause metastasis of benign rat mammary tumor cells. To investigate whether S100A4 plays an important role in the invasion and metastasis of gastric cancers, we examined the gene mutations in the coding regions and expression patterns of the S100A4 in gastric adenocarcinoma in Korea. Moderate to strong expression of S100A4 was found in 53 (68.8%) of the 77 gastric adenocarcinomas, whilst normal gastric epithelium either failed to stain or showed weak staining. Interestingly, S100A4 expression was more frequently observed in gastric cancer patients with advanced gastric cancer (p=0.039), positive lymph node metastasis (p=0.001), and peritoneal dissemination (p=0.022). No gene mutations were found in the analyzed genomic area in 77 gastric adenocarcinomas and 15 gastric cancer cell lines. We found one single nucleotide polymorphism without an amino acid change, A99G, in two cases. These data suggest that the overexpression of S100A4 may be closely related to the aggressiveness of gastric cancer in Korea.
Cho
Yong Gu
YG
Department of Pathology, Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Nam
Suk Woo
SW
Kim
Tae Yon
TY
Kim
Young Sil
YS
Kim
Chang Jae
CJ
Park
Jik Young
JY
Lee
Jong Heun
JH
Kim
Hong Sug
HS
Lee
Jong Woo
JW
Park
Cho Hyun
CH
Song
Young Hwa
YH
Lee
Sug Hyung
SH
Yoo
Nam Jin
NJ
Lee
Jung Young
JY
Park
Won Sang
WS
D000230:Adenocarcinoma / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D001483:Base Sequence; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D007723:Korea; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D018807:Polymorphism, Single-Stranded Conformational; D011379:Prognosis; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins / Q000235:genetics* / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins; C077591:S100A4 protein, human