CSF-1 as a regulator of macrophage activation and immune responses.
Macrophage activation is a key determinant of susceptibility and pathology in a variety of inflammatory diseases. The extent of macrophage activation is tightly regulated by a number of pro-inflammatory cytokines (e.g. IFN-gamma, IL-2, GM-CSF, IL-3) and anti-inflammatory cytokines (e.g. IL-4, IL-10, TGF-beta). Macrophage colony-stimulating factor (CSF-1/M-CSF) is a key differentiation, growth and survival factor for monocytes/macrophages and osteoclasts. The role of this factor in regulating macrophage activation is often overlooked. This review will summarize our current understanding of the effects of CSF-1 on the activation state of mature macrophages and its role in regulating immune responses.
Sweet
Matthew J
MJ
CRC for Chronic Inflammatory Diseases, Institute for Molecular Bioscience and Department of Microbiology/Parasitology, University of Queensland, Qld 4072, Australia. m.sweet@imb.uq.edu.au
Hume
David A
DA
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002470:Cell Survival; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007239:Infections; D007249:Inflammation; D007962:Leukocytes / Q000378:metabolism; D008070:Lipopolysaccharides / Q000378:metabolism; D008262:Macrophage Activation; D016173:Macrophage Colony-Stimulating Factor / Q000378:metabolism / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D051193:Toll-Like Receptors
D016207:Cytokines; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors; D016173:Macrophage Colony-Stimulating Factor