title: CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer.
abstract: Infiltrating CD1a(+) dendritic cells (DCs) have been associated with increased survival in a number of human cancers. This study investigated DC infiltration within breast cancers and the association with survival. Classical established prognostic factors, of tumour size, lymph node status, histological grade, lympho-vascular invasion, the KI-67 (MIB-1) fraction and the Nottingham Prognostic Index (NPI) were also compared. A total of 48 breast cancer patients were followed from the time of surgery and CD1a density analysis for 5 years or until death. Our data set validated previous studies, which show a relationship between survival and the NPI (P<0.001), tumour size (P<0.01) and lymph node status (P<0.05). Although more patients were alive at the 5-year time point in the group with higher CD1a DC density than the lower CD1a DC group, this failed to reach statistical significance at the P=0.05 level. Analysis at 10 years postsurgery is required to investigate the association further.
authors.affiliation: Breast, Endocrine and Surgical Oncology Unit and Tumour Immunology Laboratory, Department of Surgery, University of Adelaide, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia. bcoventry@medicine.edu.au
authors.forename: B J
authors.initials: BJ
authors.lastname: Coventry
authors.forename: J
authors.initials: J
authors.lastname: Morton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018949:Antigens, CD1 / Q000032:analysis*; D001943:Breast Neoplasms / Q000473:pathology*; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D018949:Antigens, CD1; C419393:CD1a antigen