title: Plasticity and cytokinetic dynamics of the hair follicle mesenchyme during the hair growth cycle: implications for growth control and hair follicle transformations.
abstract: Hair fiber production is the macroscopic end-point of a highly complex set of interactions between the hair follicle's epithelial and mesenchymal components. The nature of this relationship is largely set during hair follicle morphogenesis, but is dramatically revisited in the adult during the unique tissue remodeling events required for hair follicle cycling. Whereas significant attention has focused on the fate of the hair follicle epithelium during these events, associated changes in hair follicle fibroblast subpopulations remain unclear. Here, we present a speculative review that represents a critical and innovative synthesis of the current literature and summarizes a recently submitted original study by the authors, on the nature of hair cycle-dependent fibroblast dynamics and on how perturbations thereof may lead to several clinical manifestations of altered human hair growth.
authors.affiliation: Department of Biomedical Sciences, School of Life Sciences, University of Bradford, Bradford, West Yorkshire, UK. dtobin@bradford.ac.uk
authors.forename: Desmond J
authors.initials: DJ
authors.lastname: Tobin
authors.forename: Andrei
authors.initials: A
authors.lastname: Gunin
authors.forename: Markus
authors.initials: M
authors.lastname: Magerl
authors.forename: Ralf
authors.initials: R
authors.lastname: Paus
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D003238:Connective Tissue / Q000196:embryology; D004622:Embryo, Mammalian / Q000166:cytology; D005314:Embryonic and Fetal Development; D005347:Fibroblasts / Q000502:physiology; D018859:Hair Follicle / Q000196:embryology*; D006801:Humans; D008648:Mesoderm / Q000502:physiology*