Fetal programming for adult disease: where next?
The Barker hypothesis of fetal programming for adult cardiovascular and metabolic diseases has attracted much interest over the past few years. In this review, we summarize the main studies in this field, give a brief outline of some of the laboratory models used to investigate this hypothesis and discuss potential mechanisms underlying these clinical observations that are amenable to future research.
Khan
I Y
IY
Maternal and Fetal Research Unit, St. Thomas' Hospital, London, UK.
Lakasing
L
L
Poston
L
L
Nicolaides
K H
KH
D001724:Birth Weight; D002318:Cardiovascular Diseases / Q000196:embryology*; D005260:Female; D005333:Fetus / Q000196:embryology*; D006801:Humans; D039382:Maternal Nutritional Physiological Phenomena; D008659:Metabolic Diseases / Q000196:embryology*; D009017:Morbidity; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D018607:Pregnancy Reduction, Multifetal