title: Iron overloading inhibits dentine mineralization.
abstract: The present study reveals the inhibitory effect of iron intoxication on the process of dentine mineralization. Wistar rats were injected intraperitoneally with iron dextran at 0.88 g/kg body weight per day for 10 days during the period of odontogenesis. An age-matched group was injected intraperitoneally with bisodium etidronate (EHBP) at 20 mg/kg body weight per day for 10 days. Another age-matched group was treated with similar amounts of saline intraperitoneally and considered as control. At the end of the experimental period the animals intoxicated with iron exhibited non-mineralized dentine and mineralized bone. The animals treated with EHBP showed non-mineralized dentine and bone. These findings would suggest the existence of different mineralization mechanisms for bone and dentine.
authors.affiliation: Department of Histology and Embryology, Faculty of Dentistry, University of Buenos Aires.
authors.forename: R C
authors.initials: RC
authors.lastname: De Lucca
authors.forename: P M
authors.initials: PM
authors.lastname: Mandalunis
authors.forename: A M
authors.initials: AM
authors.lastname: Ubios
mesh_terms: D000539:Alveolar Process / Q000187:drug effects / Q000503:physiopathology; D000818:Animals; D002113:Calcification, Physiologic / Q000187:drug effects / Q000502:physiology; D003804:Dentin / Q000187:drug effects / Q000503:physiopathology*; D012968:Etidronic Acid / Q000494:pharmacology; D006397:Hematinics / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D019190:Iron Overload / Q000503:physiopathology*; D007505:Iron-Dextran Complex / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014074:Tooth Calcification / Q000187:drug effects / Q000502:physiology*
chemical_list: D006397:Hematinics; D007505:Iron-Dextran Complex; D012968:Etidronic Acid