title: Enantioseparation of dihydrofurocoumarin derivatives by various separation modes of capillary electrophoresis.
abstract: Chiral dihydrofurocoumarin compounds are currently the focus of industrial and pharmacological research. These derivatives have been shown to possess many physiological properties that could be medically beneficial. This work proposes four different chiral separation methods using capillary electrophoresis and micellar capillary electrophoresis (MCE). Several different cyclodextrin chiral selectors were examined to evaluate their effectiveness in the enantioseparation of dihydrofurocoumarins. In addition, the effects of the chiral selector concentration, the presence of an organic modifier, run buffer pH, and in two cases, the ratio between the chiral selector and an additional charged pseudophase were investigated. Overall, the best separations for this class of chiral compounds were achieved using sulfated beta-cyclodextrins at low pH in the reversed polarity mode.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, IA 50011-3111, USA.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Egger
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Juraj
authors.initials: J
authors.lastname: Sevcík
authors.forename: Eva
authors.initials: E
authors.lastname: Tesarová
authors.forename: Roman
authors.initials: R
authors.lastname: Rozhkov
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Armstrong
mesh_terms: D000925:Anticoagulants / Q000302:isolation & purification*; D003374:Coumarins / Q000302:isolation & purification; D003505:Cyclodextrins; D019075:Electrophoresis, Capillary / Q000379:methods*; D011564:Furocoumarins / Q000302:isolation & purification*; D057927:Hydrophobic and Hydrophilic Interactions; D000432:Methanol; D008823:Micelles; D013237:Stereoisomerism
chemical_list: D000925:Anticoagulants; D003374:Coumarins; D003505:Cyclodextrins; D011564:Furocoumarins; D008823:Micelles; D000432:Methanol