title: Non-enzymatic oligomerization of racemic adenosine 5'-phosphorimidazolide on Na(+)-montmorillonite.
abstract: In this study, we have investigated non-enzymatic oligomerization of an activated racemic mononucleotide in the presence of Na(+)-montmorillonite. Oligomers up to the decamer in length were formed by oligomerization reactions of activated D- and L-mononucleotides. Similarly, oligomerization of an activated racemic mononucleotide results in the formation of oligomers up to the octamer. These results suggest that montmorillonite catalysis is quite efficient for the oligomerization of racemic monomers, though it is somewhat less efficient than that of D- and L-monomers.
authors.affiliation: Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Urata
authors.forename: C
authors.initials: C
authors.lastname: Aono
authors.forename: N
authors.initials: N
authors.lastname: Ohmoto
authors.forename: Y
authors.initials: Y
authors.lastname: Shimamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Akagi
mesh_terms: D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000737:chemistry*; D001546:Bentonite; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D013237:Stereoisomerism
chemical_list: D009843:Oligoribonucleotides; D001546:Bentonite; C010671:adenosine 5'-phosphoroimidazolide; D000249:Adenosine Monophosphate