title: Systemic and topical drugs for aging skin.
abstract: The rejuvenation of aging skin is a common desire for our patients, and several options are available. Although there are some systemic methods, the most commonly used treatments for rejuvenation of the skin are applied topically. The most frequently used topical drugs include retinoids, alpha hydroxy acids (AHAs), vitamin C, beta hydroxy acids, anti-oxidants, and tocopherol. Combination therapy is frequently used; particularly common is the combination of retinoids and AHAs. Systemic therapies available include oral retinoids and vitamin C. Other available therapies such as chemical peels, face-lifts, collagen, and botulinum toxin injections are not discussed in this article.
authors.affiliation: Albert Schweitzer Hospital, Department of Dermatology, P.O. Box 306, 3300 AH Dordrecht, The Netherlands.
authors.forename: Michael
authors.initials: M
authors.lastname: Kockaert
authors.forename: Martino
authors.initials: M
authors.lastname: Neumann
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000975:Antioxidants / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage / Q000627:therapeutic use*; D012176:Retinoids / Q000008:administration & dosage / Q000627:therapeutic use*; D015595:Skin Aging / Q000187:drug effects*; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D003879:Dermatologic Agents; D012176:Retinoids; D014810:Vitamin E; D015474:Isotretinoin; D001205:Ascorbic Acid