The influence of Atorvastatin on ultrastructure of rat pancreatic exocrine cells in the course of experimental intoxication with ethanol.
The experiment was carried out on mature Wistar male rats. The animals from experimental group I received Atorvastatin in the dose 0.28 mg/24 h for 3 weeks. Experimental group II received 20% ethanol ad libitum apart from Atorvastatin. Ultrastructural examinations of pancreatic exocrine cells showed the stimulation of secretory processes in cells of animals receiving Atorvastatin and considerable damage of cell organelles in experimental group II, more intense than in the pancreas of control animals which drank ethanol.
Visconti
Józef
J
Department of Histology and Embryology, Laboratory of Experimental Cytology, Medical University of Lublin.
Celiński
Krzysztof
K
Stepniewska
Maria
M
Sekita-Krzak
Joanna
J
D000435:Alcoholic Intoxication / Q000473:pathology*; D000818:Animals; D000924:Anticholesteremic Agents / Q000633:toxicity*; D000069059:Atorvastatin; D004347:Drug Interactions; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity*; D006538:Heptanoic Acids / Q000633:toxicity*; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D019512:Pancreatitis, Alcoholic / Q000473:pathology*; D011758:Pyrroles / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D011758:Pyrroles; D000431:Ethanol; D000069059:Atorvastatin