Bacterial genomics and vaccine design.
Complete genome sequences are available for an increasing number of pathogenic bacteria. These new data are beginning to make an impact on the understanding of bacterial evolution and virulence. Thus far, however, vaccine development has had little benefit from genomics. Here we discuss how genomic sequence is being used in ways that could help identify useful bacterial antigens or create attenuated live vaccines.
Sampson
Samantha L
SL
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
Rengarajan
Jyothi
J
Rubin
Eric J
EJ
D001426:Bacterial Proteins / Q000032:analysis / Q000235:genetics / Q000276:immunology; D001428:Bacterial Vaccines; D001483:Base Sequence; D004251:DNA Transposable Elements / Q000235:genetics; D015195:Drug Design; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D018390:Gene Targeting; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D023281:Genomics; D006801:Humans; D016254:Mutagenesis, Insertional; D020411:Oligonucleotide Array Sequence Analysis; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion
D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D004251:DNA Transposable Elements