L-arginine ingestion after rest and exercise: effects on glucose disposal.
OBJECTIVE
There is considerable interest, both in health and disease, in enhancing postexercise glucose uptake and glycogen resynthesis in skeletal muscle. The amino acid, arginine, is known to stimulate insulin release and enhance glucose-stimulated insulin release.


METHODS
The present investigation examined whether an oral dose of L-arginine (10 g), when given with 70 g carbohydrate (CHO, in the form of simple sugars) improved factors associated with glucose disposal in previously exercised and nonexercised healthy males. The effects of different modes of activity (resistance or cycling exercise) upon these factors were also examined.


RESULTS
Whole-blood glucose and serum insulin concentrations after L-arginine + CHO ingestion were not significantly different from the placebo condition (glycine + CHO ingestion) in all experimental treatments (nonexercised, resistance exercise, and cycling exercise). Similarly, CHO oxidation, forearm blood flow, blood pressure, and heart rate during the postingestion period were unaffected by L-arginine + CHO consumption in all three experimental treatments.


CONCLUSIONS
A 10-g oral dose of L-arginine was found to have no effect on blood glucose disposal in human subjects after oral CHO ingestion, either when rested or after different modes of exercise known to differentially affect glucose disposal. These results suggest that the addition of L-arginine to a CHO beverage would not augment postexercise CHO replenishment in healthy human subjects.
Robinson
Tristan M
TM
School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom. t.m.robinson@sheffield.ac.uk
Sewell
Dean  A
D
Greenhaff
Paul L
PL
D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D001120:Arginine / Q000008:administration & dosage*; D001775:Blood Circulation / Q000187:drug effects*; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D005542:Forearm / Q000098:blood supply; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D012146:Rest / Q000502:physiology*
D001786:Blood Glucose; D007328:Insulin; D001120:Arginine; D005947:Glucose