title: Synthesis of noraristeromycin analogues possessing SAH hydrolase inhibitory activity for the development of antimalaria agents.
abstract: Noraristeromycin analogues such as 3',4'-anhydronoraristeromycins, 2-amino-3',4'-anhydronoraristeromycin and N6-cyclopropylnoraristeromycin were synthesized and their inhibitory activity against human and Plasmodium falciparum (P. falciparum) recombinant SAH hydrolase was investigated. Among them, 3',4'-anhydronoraristeromycin showed inhibitory activity against human recombinant S-adenosyl-L-homocysteine hydrolase (Ki = 12.4 microM, Kinact = 0.55 min-1).
authors.affiliation: Laboratory of Molecular Biochemistry, Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1-1, Gifu 501-1193, Japan.
authors.forename: Hiroharu
authors.initials: H
authors.lastname: Kojima
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kozaki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Ueno
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kitade
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D043383:Adenosylhomocysteinase; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D006867:Hydrolases / Q000037:antagonists & inhibitors; D010963:Plasmodium falciparum / Q000187:drug effects; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors
chemical_list: D000962:Antimalarials; D011994:Recombinant Proteins; C030034:aristeromycin; D006867:Hydrolases; D043383:Adenosylhomocysteinase; D000241:Adenosine