title: Treatment of neuroendocrine tumours with infusional 5-fluorouracil, folinic acid and streptozocin.
abstract: A standardised, effective systemic therapy for metastatic neuroendocrine tumours (NETs) has not been established to date. We reviewed the management of 15 patients with inoperable, metastatic NET treated systematically with a combination chemotherapy regimen of infusional 5-fluorouracil, folinic acid and streptozocin. Overall objective response rate was 53% and tolerability was excellent.
authors.affiliation: Oncology Centre (Box 193), Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Gonzalez
authors.forename: S
authors.initials: S
authors.lastname: Biswas
authors.forename: L
authors.initials: L
authors.lastname: Clifton
authors.forename: P G
authors.initials: PG
authors.lastname: Corrie
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018450:Disease Progression; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D018358:Neuroendocrine Tumors / Q000188:drug therapy* / Q000473:pathology; D012189:Retrospective Studies; D013311:Streptozocin / Q000008:administration & dosage; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D013311:Streptozocin; D002955:Leucovorin; D005472:Fluorouracil