Molecular pathology of skin carcinogenesis due to arsenicalism from coal-burning.
Arsenicalism has been observed throughout the world and has become an urgent public health concern. The authors explored the mechanism of carcinogenesis of inorganic arsenic in patients with arsenicalism from coal-burning pollution. The 68 subjects were divided into 3 groups--carcinoma, precarcinoma, and common-on the basis of pathological diagnosis. The expressions of proliferating cell nuclear antigen (PCNA), mutant-type P53, and B-cell lymphoma/leukemia-2 (BCL-2) proteins were detected by immunohistochemical staining. PCNA, P53, and BCL-2 proteins were overexpressed. The proteins' overexpressions correlated with the pathological changes seen in each pathological study group (i.e., common < precarcinoma < carcinoma). Statistical correlation was observed between P53 and BCL-2, and between PCNA and BCL-2. The authors concluded that cell proliferation, antiapoptosis, and up-regulation of the mutant-type P53 gene played vital roles in the pathological development of arsenicalism.
Hu
Chang-Jun
CJ
Department of Laboratory Medicine, Huaihua Medical College, Hunan Province, People's Republic of China. hcj66@21cn.com
Zhang
Ai-Hua
AH
Huang
Hsiao-Hsin
HH
D001151:Arsenic / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000235:genetics / Q000473:pathology; D003031:Coal; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000009:adverse effects*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D011230:Precancerous Conditions / Q000209:etiology / Q000235:genetics / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D012878:Skin Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
D003031:Coal; D004785:Environmental Pollutants; D018809:Proliferating Cell Nuclear Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D001151:Arsenic