title: Lymph node metastasis could be predicted by evaluation of macrophage infiltration and hsp70 expression in superficial carcinoma of the esophagus.
abstract: Macrophages have been reported to play an important role in suppressing tumor growth, and heat shock protein 70 (HSP70) in presenting tumor specific antigens. The objective of the present study was to investigate the relationship between lymph node metastasis and these two molecular biological markers in superficial esophageal carcinoma. Subjects were 37 patients with untreated submucosal esophageal carcinoma who underwent curative surgery. Among these patients, expression of CD68-positive macrophages in the tumor stroma and expression of HSP70 in tumor cells were analyzed. The results demonstrated that expression of CD68-positive macrophages was significantly greater among patients without lymph node metastasis (p<0.0001), and a significant correlation existed between HSP70 expression and CD68 expression (p=0.0125). In superficial esophageal carcinoma, lymph node metastasis is correlated with expression of CD68-positive macrophages in tumor stroma and expression of HSP70 in tumor cells. These two markers may therefore prove useful for therapy planning.
authors.affiliation: Department of Oncological Science (Surgery II), Oita Medical University, Oita 879-5593, Japan. surg2@oita-med.ac.jp
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Noguchi
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Wada
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Takeno
authors.forename: Hatsuo
authors.initials: H
authors.lastname: Moriyama
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kimura
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Uchida
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis; D015214:Antigens, Differentiation, Myelomonocytic / Q000096:biosynthesis; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008264:Macrophages / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D018840:HSP70 Heat-Shock Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule