title: [Comparison of SIB-IMRT treatment plans for upper esophageal carcinoma].
abstract: OBJECTIVE
  To implement simultaneous integrated boost intensity-modulated radiotherapy(SIB-IMRT) plans for upper esophageal carcinoma and investigate the dose profiles of tumor and electively treated region and the dose to organs at risk (OARs).
  
  
  METHODS
  SIB-IMRT plans were designed for two patients with upper esophageal carcinoma. Two target volumes were predefined: PTV1, the target volume of the primary lesion, which was given to 67.2 Gy, and PTV2, the target volume of electively treated region, which was given to 50.4 Gy. With the same dose-volume constraints, but different beams arrangements (3, 5, 7, or 9 equispaced coplanar beams), four plans were generated. Indices, including dose distribution, dose volume histogram (DVH) and conformity index, were used for comparison of these plans.
  
  
  RESULTS
  The plan with three intensity-modulated beams could produce good dose distribution for the two target volumes. The dose conformity to targets and the dose to OARs were improved as the beam number increased. The dose distributions in targets changed little when the beam number increased from 7 to 9.
  
  
  CONCLUSIONS
  Five to seven intensity-modulated beams can produce desirable dose distributions for simultaneous integrated boost (SIB) treatment for upper esophageal carcinoma. The primary tumor can get higher equivalent dose by SIB treatments. It is easier and more efficient to design plans with equispaced coplanar beams. The efficacy of SIB-IMRT remains to be determined by the clinical outcome.
authors.affiliation: Department of Radiation Oncology, Cancer Hospital, CAMS, PUMC, Beijing 100021, China.
authors.forename: Wei-hua
authors.initials: WH
authors.lastname: Fu
authors.forename: Lv-hua
authors.initials: LH
authors.lastname: Wang
authors.forename: Zong-mei
authors.initials: ZM
authors.lastname: Zhou
authors.forename: Jian-rong
authors.initials: JR
authors.lastname: Dai
authors.forename: Yi-min
authors.initials: YM
authors.lastname: Hu
mesh_terms: D000368:Aged; D004307:Dose-Response Relationship, Radiation; D004938:Esophageal Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D011829:Radiation Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*