What information is needed to design effective vaccination against intracellular pathogens causing chronic disease?
An appreciation of global features of immune regulation may lead to vaccination strategies effective in a genetically diverse population against a number of intracellular pathogens that cause chronic disease. Such global strategies appear more straightforward than strategies requiring a detailed knowledge of the specificity of 'protective T-cells'. Global strategies may be effective against the virus, bacteria and protozoa that respectively cause AIDS, tuberculosis and the leishmaniases.
Bretscher
Peter A
PA
Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada. bretschr@duke.usask.ca
Hamilton
Duane
D
Ogunremi
Oladele
O
D016915:AIDS Vaccines / Q000276:immunology; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002908:Chronic Disease; D003141:Communicable Diseases / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D017053:Infection Control; D007898:Leishmaniasis, Visceral / Q000276:immunology / Q000517:prevention & control; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology / Q000517:prevention & control; D032581:Tuberculosis Vaccines / Q000008:administration & dosage / Q000276:immunology; D014611:Vaccination
D016915:AIDS Vaccines; D032581:Tuberculosis Vaccines