Canine distemper, a re-emerging morbillivirus with complex neuropathogenic mechanisms.
Paramyxoviruses are responsible for a wide variety of diseases both in humans and in animals. Common to many paramyxoviruses is the fact that they can cause neurological symptoms in their final host. Newly discovered paramyxoviruses, such as the Hendra and Nipah viruses, show the same pattern of pathogenesis as that of the paramyxoviruses already known. Canine distemper virus (CDV) is a well-studied member of the genus Morbillivirus. Study of the neuropathogenesis of CDV might give insight into disease mechanisms and suggest approaches for the prevention of other recently discovered paramyxovirus infections.
Griot
Christian
C
Institute of Virology and Immunoprophylaxis, Swiss Federal Veterinary Office, 3147 Mittelhäusern, Switzerland. Christian.Griot@ivi.admin.ch
Vandevelde
Marc
M
Schobesberger
Martina
M
Zurbriggen
Andreas
A
D000818:Animals; D002531:Cerebellum / Q000473:pathology / Q000821:virology; D021821:Communicable Diseases, Emerging / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D003711:Demyelinating Diseases / Q000473:pathology / Q000662:veterinary / Q000821:virology; D004216:Distemper / Q000473:pathology / Q000821:virology; D004217:Distemper Virus, Canine / Q000472:pathogenicity; D004283:Dog Diseases / Q000473:pathology / Q000821:virology*; D004285:Dogs; D009186:Myelin Sheath / Q000473:pathology / Q000821:virology; D018184:Paramyxoviridae Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D018098:Paramyxovirinae / Q000472:pathogenicity*; D015047:Zoonoses