title: Specific protein targeting during cell differentiation: polarized localization of Fus1p during mating depends on Chs5p in Saccharomyces cerevisiae.
abstract: In budding yeast, chs5 mutants are defective in chitin synthesis and cell fusion during mating. Chs5p is a late-Golgi protein required for the polarized transport of the chitin synthase Chs3p to the membrane. Here we show that Chs5p is also essential for the polarized targeting of Fus1p, but not of other cell fusion proteins, to the membrane during mating.
authors.affiliation: Molecular, Cellular, and Developmental Biology Department, Yale University, New Haven, Connecticut 06520-8103, USA.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Santos
authors.forename: Michael
authors.initials: M
authors.lastname: Snyder
mesh_terms: D002451:Cell Compartmentation / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics*; D002462:Cell Membrane / Q000235:genetics / Q000378:metabolism; D016764:Cell Polarity / Q000235:genetics*; D002478:Cells, Cultured; D002686:Chitin / Q000096:biosynthesis; D002687:Chitin Synthase / Q000235:genetics / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D008561:Membrane Fusion / Q000235:genetics; D008565:Membrane Proteins; D009154:Mutation / Q000235:genetics; D021381:Protein Transport / Q000235:genetics*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D012098:Reproduction / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins
chemical_list: C490024:FUS1 protein, S cerevisiae; D005656:Fungal Proteins; D008565:Membrane Proteins; D011993:Recombinant Fusion Proteins; D029701:Saccharomyces cerevisiae Proteins; D002686:Chitin; C491360:CHS5 protein, S cerevisiae; D002687:Chitin Synthase