title: Higher plasma 5-hydroxyindoleacetic acid levels are associated with SSRI-induced nausea.
abstract: We investigated the association between selective serotonin reuptake inhibitors (SSRIs; paroxetine or fluvoxamine) and nausea with regard to plasma 5-hydroxyindoleacetic acid (p5-HIAA) levels. Forty-eight patients meeting the DSM-IV criteria for major depressive disorder and treated with paroxetine or fluvoxamine participated in this study. p5-HIAA levels after SSRI administration were significantly higher in the nausea group than those in the nonnausea group (nausea group: 8.0 +/- 4.6 ng/ml; nonnausea group: 3.6 +/- 2.2 ng/ml; p < 0.01). On the other hand, no significant difference was found between the nausea and nonnausea group in terms of p5-HIAA levels before each drug administration. These results suggest that SSRI-induced nausea is associated with serotonergic hyperactivity in the gastrointestinal tract.
authors.affiliation: Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyusyu, Japan. EZD04735@nifty.com
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Ueda
authors.forename: Reiji
authors.initials: R
authors.lastname: Yoshimura
authors.forename: Koji
authors.initials: K
authors.lastname: Shinkai
authors.forename: Yumi
authors.initials: Y
authors.lastname: Sakata
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura
mesh_terms: D000098:Acetophenones / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007211:Indoles / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000097:blood* / Q000139:chemically induced*; D010091:Oximes / Q000009:adverse effects / Q000627:therapeutic use; D017374:Paroxetine / Q000009:adverse effects / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000098:Acetophenones; D007211:Indoles; D010091:Oximes; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; C024139:indole-3-lactic acid; C108005:fluxofenim