title: The impact of adverse childhood experiences on health problems: evidence from four birth cohorts dating back to 1900.
abstract: BACKGROUND
  We examined the relationship of the number of adverse childhood experiences (ACE score) to six health problems among four successive birth cohorts dating back to 1900 to assess the strength and consistency of these relationships in face of secular influences the 20th century brought in changing health behaviors and conditions. We hypothesized that the ACE score/health problem relationship would be relatively "immune" to secular influences, in support of recent studies documenting the negative neurobiologic effects of childhood stressors on the developing brain.
  
  
  METHODS
  A retrospective cohort study of 17,337 adult health maintenance organization (HMO) members who completed a survey about childhood abuse and household dysfunction, as well as their health. We used logistic regression to examine the relationships between ACE score and six health problems (depressed affect, suicide attempts, multiple sexual partners, sexually transmitted diseases, smoking, and alcoholism) across four successive birth cohorts: 1900-1931, 1932-1946, 1947-1961, and 1962-1978.
  
  
  RESULTS
  The ACE score increased the risk for each health problem in a consistent, strong, and graded manner across four birth cohorts (P < 0.05). For each unit increase in the ACE score (range: 0-8), the adjusted odds ratios (ORs) for depressed affect, STDs, and multiple sexual partners were increased within a narrow range (ORs: 1.2-1.3 per unit increase) for each of the birth cohorts; the increase in risk for suicide attempts was stronger but also in a narrow range (ORs: 1.5-1.7).
  
  
  CONCLUSIONS
  Growing up with ACEs increased the risk of numerous health behaviors and outcomes for 20th century birth cohorts, suggesting that the effects of ACEs on the risk of various health problems are unaffected by social or secular changes. Research showing detrimental and lasting neurobiologic effects of child abuse on the developing brain provides a plausible explanation for the consistency and dose-response relationships found for each health problem across birth cohorts, despite changing secular influences.
authors.affiliation: National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341-3717, USA. skd7@cdc.gov
authors.forename: Shanta R
authors.initials: SR
authors.lastname: Dube
authors.forename: Vincent J
authors.initials: VJ
authors.lastname: Felitti
authors.forename: Maxia
authors.initials: M
authors.lastname: Dong
authors.forename: Wayne H
authors.initials: WH
authors.lastname: Giles
authors.forename: Robert F
authors.initials: RF
authors.lastname: Anda
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000209:etiology; D002648:Child; D015331:Cohort Studies; D003863:Depression / Q000209:etiology; D005260:Female; D006262:Health; D006801:Humans; D008016:Life Change Events; D016015:Logistic Models; D008297:Male; D012307:Risk Factors; D012747:Sexual Partners; D012749:Sexually Transmitted Diseases / Q000453:epidemiology; D012907:Smoking; D013406:Suicide, Attempted; D011795:Surveys and Questionnaires