The power of the 3' UTR: translational control and development.
Many crucial decisions, such as the location and timing of cell division, cell-fate determination, and embryonic axes establishment, are made in the early embryo, a time in development when there is often little or no transcription. For this reason, the control of variation in gene expression in the early embryo often relies on post-transcriptional control of maternal genes. Although the early embryo is rife with translational control, controlling mRNA activity is also important in other developmental processes, such as stem-cell proliferation, sex determination, neurogenesis and erythropoiesis.
Kuersten
Scott
S
Laboratory of Genetics, University of Wisconsin-Madison, 445 Henry Mall, Madison, Wisconsin 53706, USA. rskuersten@wisc.edu
Goodwin
Elizabeth B
EB
D020413:3' Untranslated Regions / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans; D002455:Cell Division; D019070:Cell Lineage; D002467:Cell Nucleus / Q000378:metabolism; D004330:Drosophila; D005260:Female; D018507:Gene Expression Regulation, Developmental; D008540:Meiosis; D051379:Mice; D008938:Mitosis; D008954:Models, Biological; D009035:Mothers; D014176:Protein Biosynthesis; D012313:RNA / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D019849:Sex Determination Processes
D020413:3' Untranslated Regions; D012333:RNA, Messenger; D012313:RNA