title: Conditional live virus as a novel approach towards a safe live attenuated HIV vaccine.
abstract: To control the worldwide spread of HIV, a safe and effective prophylactic vaccine is urgently needed. Studies with the simian immunodeficiency virus demonstrated that a live attenuated virus can be effective as a vaccine, but serious concerns about the safety of such a vaccine virus have arisen. We propose a conditional live virus, of which the replication can be switched on and off at will, as a novel approach for an HIV vaccine.
authors.affiliation: Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands. a.t.das@amc.uva.nl
authors.forename: Atze T
authors.initials: AT
authors.lastname: Das
authors.forename: Xue
authors.initials: X
authors.lastname: Zhou
authors.forename: Monique
authors.initials: M
authors.lastname: Vink
authors.forename: Bep
authors.initials: B
authors.lastname: Klaver
authors.forename: Ben
authors.initials: B
authors.lastname: Berkhout
mesh_terms: D016915:AIDS Vaccines / Q000009:adverse effects / Q000276:immunology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D004318:Doxycycline / Q000494:pharmacology; D015316:Genetic Therapy; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1 / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D018449:SAIDS Vaccines / Q000276:immunology; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology*
chemical_list: D016915:AIDS Vaccines; D000900:Anti-Bacterial Agents; D018449:SAIDS Vaccines; D014613:Vaccines, Attenuated; D004318:Doxycycline