title: The synthesis of pyrrole(Py)/imidazole(Im) polyamide CPI conjugates which possess DNA interstrand cross-linking activity.
abstract: Covalent dimers of ImPyLDu86 with various linkers were synthesized and their DNA interstrand cross-linking abilities were examined. Denaturing polyacrylamide gel electrophoresis indicated that dimer molecule with tetramethylene linker efficiently produced interstrand cross-link only in the presence of appropriate partner PyIm triamides.
authors.affiliation: Division of Biofunctional Molecules, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda, Tokyo 101-0062, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Bando
authors.forename: H
authors.initials: H
authors.lastname: Iida
authors.forename: I
authors.initials: I
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Sugiyama
mesh_terms: D001483:Base Sequence; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D019281:Dimerization; D015195:Drug Design; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D009757:Nylons / Q000138:chemical synthesis / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D003432:Cross-Linking Reagents; D007093:Imidazoles; D009757:Nylons; D009838:Oligodeoxyribonucleotides; D011758:Pyrroles; D004247:DNA