Immunologic memory with no detectable bactericidal antibody response to a first dose of meningococcal serogroup C conjugate vaccine at four years.
Fourteen children with no detectable bactericidal antibody response to a first dose of meningococcal C conjugate vaccine at 4 years of age were given a booster dose of the same vaccine 2 years later. A rapid 1000-fold rise in postimmunization bactericidal antibody titers, a measured either 7 or 14 days later, suggested previous immunologic priming.
McVernon
Jodie
J
Oxford Vaccine Group, Department of Paediatrics, John Radcliffe Hospital, Headington, UK. jodie.mcvernon@imm.ox.ac.uk
MacLennan
Jenny
J
Pollard
Andrew J
AJ
Oster
Philipp
P
Wakefield
Mark J
MJ
Danzig
Lisa
L
Moxon
E Richard
ER
D000907:Antibodies, Bacterial / Q000276:immunology*; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary; D007156:Immunologic Memory / Q000276:immunology*; D008297:Male; D008589:Meningococcal Infections / Q000276:immunology* / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D009345:Neisseria meningitidis / Q000276:immunology*; D011336:Probability; D011446:Prospective Studies; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D013997:Time Factors
D000907:Antibodies, Bacterial; D022401:Meningococcal Vaccines; C410218:serogroup C meningococcal conjugate vaccine