Anti-HIV-1 activity of L-DNA quadruplex.
Zintevir is a DNA 17mer that forms a quadruplex and shows strong anti-human immunodeficiency virus (HIV)-1 activity. The quadruplex formation is thought to be essential for the anti-HIV-1 activity of Zintevir. We synthesized the enantiomer of Zintevir and evaluated its structure and anti-HIV-1 activity. The results showed that the enantiomer has anti-HIV-1 activity comparable to that of Zintevir although it forms the mirror image quadruplex structure of Zintevir.
Urata
Hidehito
H
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
Kumashiro
Tetsuya
T
Otake
Toru
T
Kawahata
Takuya
T
Akagi
Masao
M
D019380:Anti-HIV Agents / Q000494:pharmacology*; D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects*; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000494:pharmacology*
D019380:Anti-HIV Agents; D009841:Oligonucleotides; D004247:DNA; C098172:T 30177