Antioxidant therapy in intensive care.
OBJECTIVE
This review intends to summarize the recent findings regarding the presence of increased oxidative stress in critically ill patients and its potential pathophysiologic role, as well as the results of recent clinical trials of antioxidant therapies.


RESULTS
Several lines of evidence confirm the increase in oxidative stress during critical illness. The oxidative damage to cells and tissues eventually contributes to organ failure. Prophylactic administration of antioxidant vitamins or glutamine, incorporated in the nutritional support or given as separate medications, efficiently attenuates the oxidative stress and in some studies improves the outcome of critically ill patients. Few data on the effects of N-acetylcysteine or trace elements have been published during the last two years.


CONCLUSIONS
Patients at risk of organ failure could benefit from the early adjunction of antioxidant treatment, including vitamins and glutamine.
Lovat
Robin
R
Department of Intensive Care Centre hospitalo-Universitaire du Sart-Tilman, Liége, Belgium.
Preiser
Jean-Charles
JC
D000975:Antioxidants / Q000627:therapeutic use*; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000628:therapy*; D006801:Humans; D018384:Oxidative Stress
D000975:Antioxidants