[Quantifying the inflammatory activity in Crohn's disease using CE dynamic MRI].
OBJECTIVE
Evaluation of dynamic contrast enhanced MRI in patients with Crohn's disease to assess local inflammatory activity.


METHODS
Prospective study of 13 patients with histologically proven Crohn's disease. Axial and coronal slices were acquired by a 1.5 T MR (Magnetom Vision, Siemens, Germany): T1 flash 2 D (TR 72.5 ms, TE 4.1 ms), T2 (TR 2730 ms, TE 138 ms), turbo-flash sequences T1 (TR 94.2 ms, TE 4.1 ms) post contrast media fat saturated (Magnevist, 0.2 ml/kg, flow 4 ml/s). In area of maximal thickening of terminal ileal wall, axial dynamic T1 sequences (TR 11 ms, TE 4.2 ms) were acquired every 1.5 s post contrast media application for a total duration of 1 min. Contrast uptake was subjectively measured by semiquantitative score and computed assisted ROI evaluation. MR parameters were correlated with CDAI (Crohn's disease activity index) and SAI (severe activity index).


RESULTS
Contrast uptake in the intestinal wall occurred after 18.5 s (range: 3.0 - 28.0), contrast upslope until plateau phase lasted for 16.1 s (range: 8.0 - 50.0). Maximum contrast enhancement into the bowel wall was 266 % (105 - 450 %) of baseline. After maximum contrast uptake, we observed a plateau phase in all cases for the total duration of measurement. A significant correlation existed for maximum contrast uptake to CDAI (r = 0.591; p = 0.033), for beginning of contrast upslope to the time until plateau phase (r = 0.822; p = 0.001), and for the time until plateau phase to CDAI (r = 0.562; p = 0.046). CDAI was on average 108, median 106; SAI was on average 114, median 115. SAI correlated significantly to CDAI (r = 0.874). Maximum contrast uptake, beginning of contrast upslope, and time until plateau phase were independent to creeping fat, local lymphadenitis, laboratory parameters, temperature, body mass index, heart frequency and systolic blood pressure.


CONCLUSIONS
Dynamic MRI enables to quantify local inflammatory activity of bowel wall in patients with Crohn's disease. Larger studies are necessary to establish this method in clinical routine.
Pauls
S
S
Abteilung Diagnostische Radiologie, Universitätsklinik Ulm. sandra.pauls@medizin.uni-ulm.de
Kratzer
W
W
Rieber
A
A
Schmidt
S A
SA
Mittrach
C
C
Adler
G
G
Brambs
H-J
HJ
Gabelmann
A
A
D000328:Adult; D003287:Contrast Media / Q000493:pharmacokinetics; D003424:Crohn Disease / Q000175:diagnosis*; D005260:Female; D019786:Gadolinium DTPA / Q000493:pharmacokinetics; D006801:Humans; D007082:Ileum / Q000473:pathology; D007089:Image Enhancement; D007413:Intestinal Mucosa / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008432:Mathematical Computing; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity
D003287:Contrast Media; D019786:Gadolinium DTPA