Waiting for ON: a major problem in patients with Parkinson disease and ON/OFF motor fluctuations.
The authors compared the two portions of the OFF period in patients with Parkinson disease and response fluctuations: time to ON (the latency from levodopa intake to turning ON) and wearing off (time from termination of the beneficial dose effect until the time when the next dose was taken). Time to ON was more than twice the duration of wearing off. Although underrecognized, time to ON is the major component of total daily OFF.
Merims
Doron
D
Department of Neurology, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49100, Israel.
Djaldetti
Ruth
R
Melamed
Eldad
E
D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000188:drug therapy* / Q000503:physiopathology*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology
D000978:Antiparkinson Agents