The fallacy of behavioral phenotyping without standardisation.
Behavioral phenotyping of mutant mice is a new and challenging task for the behavioral neuroscientist. Therefore, standardisation of the experimental conditions is required to permit comparisons between the results of experiments within and between laboratories. Once mutation-induced behavioral changes have been identified, phenotyping of mouse mutants should be performed along a systematic trajectory, which allows for an in-depth characterisation of the mutant under investigation.
van der Staay
F J
FJ
Cognitive Neurobiology, Institute for Anatomy II, University of Köln, Joseph Stelzmann Str., Cologne, Germany.
Steckler
T
T
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D004777:Environment; D005824:Genetics, Behavioral; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics / Q000523:psychology; D010641:Phenotype; D012015:Reference Standards; D015203:Reproducibility of Results