title: Salt sensitivity is not associated with hyperinsulinaemia in a sample of rural black Zimbabweans.
abstract: OBJECTIVE
  To investigate the relationship between salt sensitivity and hyperinsulinaemia in rural black African subjects.
  
  
  METHODS
  An intervention study where 27 subjects were divided into two groups; group 1 was initially salt loaded (300 mmol Na+/day), while group 2 was salt restricted (25 mmol Na+/day), each for 4 days, after which a cross-over study was done.
  
  
  METHODS
  Chidamoyo, a rural area 383 km north of Harare, Zimbabwe.
  
  
  METHODS
  Twenty-seven rural volunteers (16 women, 11 men).
  
  
  METHODS
  Systolic and diastolic blood pressures, salt sensitivity, insulin and glucose levels, body mass index and mean arterial pressure.
  
  
  RESULTS
  Mean arterial pressure, which was 91 +/- 2 mmHg on a low-salt diet, increased significantly (P < 0.01) to 105 +/- 3 mmHg on high-salt diet in the salt-sensitive subjects. In the same salt-sensitive subjects, the fasting insulin level was 8.4 +/- 0.8 microU/ml on a low-salt and 6.1 +/- 1.0 microU/ml on a high-salt diet. The difference was not statistically significant.
  
  
  CONCLUSIONS
  Although salt pressor sensitivity was demonstrated in the subjects, there was no accompanying increase but rather a decrease in fasting insulin levels, suggesting that in the short term, salt sensitivity and hyperinsulinaemia are not linked in raising blood pressure in this sample of rural Zimbabwean subjects.
authors.affiliation: Department of Physiology, University of Zimbabwe, Harare, Zimbabwe.
authors.forename: J
authors.initials: J
authors.lastname: Mufunda
authors.forename: J
authors.initials: J
authors.lastname: Chifamba
authors.forename: N
authors.initials: N
authors.lastname: Chitate
authors.forename: P M
authors.initials: PM
authors.lastname: Vengesa
mesh_terms: D000328:Adult; D001741:Black or African American; D044383:Black People; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D015992:Body Mass Index; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000208:ethnology* / Q000209:etiology*; D007004:Hypoglycemic Agents / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D012424:Rural Population; D017673:Sodium Chloride, Dietary / Q000009:adverse effects*; D015030:Zimbabwe
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D017673:Sodium Chloride, Dietary