Synthesis of a novel anticancer prodrug designed to target telomerase sequence.
A curcumin conjugate viz. 1,7-bis (4-O-glycinoyl-3-methoxyphenyl)-1,6- heptadiene-3, 5, dione (I) was synthesised and after attachment of linker (-CH2-CH2-OH) phosphitylated. This unit was attached to the deoxy-11 mer, 5'-GTT AGG GTT AG-3', a complementary sequence of telomerase RNA template. Its hybridisation with the telomerase RNA sequence, 5'-CUA ACC CUA AC-3' has been studied employing Tm.
Mishra
Satyendra
S
Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211002, India.
Tripathi
Snehlata
S
Misra
Krishna
K
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001483:Base Sequence; D009841:Oligonucleotides; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology; D019098:Telomerase / Q000737:chemistry / Q000187:drug effects*
D000970:Antineoplastic Agents; D009841:Oligonucleotides; D011355:Prodrugs; D019098:Telomerase