title: [Measurement of epidermal growth factor receptor concentration in the pre- and postoperative serum in patients with meningiomas].
abstract: OBJECTIVE
  To investigate effect of the serum concentration of epidermal growth factor receptor (EGFR) in the pre- and postoperative peripheral blood in patients with meningiomas.
  
  
  METHODS
  Using ELISA, the EGFR concentration were measured in the pre- and postoperative serum in 53 patients with meningiomas. In this study, the patients were divided into preoperative group, postoperative group (including 42 total resection, 11 subtotal resection), and 28 healthy control.
  
  
  RESULTS
  In 53 patients with meningiomas, concentration of preoperative serum EGFR was (352.93 +/- 66.18) fmol/ml, to show higher than control group (159.11 +/- 40.50) fmol/ml (P < 0.0001); Concentration of postoperative serum EGFR was (220.74 +/- 70.63) fmol/ml, to show lower than preoperative group (P < 0.001). Including in 42 patients with meningomas by total resection, serum EGFRs of the 38 patients were decreased (191.20 +/- 32.13) fmol/ml, the 4 patients with peritumoral edema were decreased (248.75 +/- 10.31) fmol/ml, to show lower than preoperative group (P < 0.001); the 11 patients with subtotal resection were decreased (322.14 +/- 89.53) fmol/ml, not to show different than preoperative group (P < 0.05).
  
  
  CONCLUSIONS
  In 92.16% patients with meningiomas, the more poison of the tumor is resected, the less the serum EGFR concentration is detected postoperatively, while the total resection of mangionmas resulted in a lowest level of EGFR. These results support the concept that human meningiomas may be autocrine EGFRs. The measurement of serum EGFR can be useful to patients with meningiomas for follow-up after surgery.
authors.affiliation: Laboratory of Neurosurgery, PUMC Hospital, CAMS, PUMC, Beijing 100730, China. kongyg@yeah.net
authors.forename: Yan-guo
authors.initials: YG
authors.lastname: Kong
authors.forename: Chang-bao
authors.initials: CB
authors.lastname: Su
authors.forename: Zu-yuan
authors.initials: ZY
authors.lastname: Ren
authors.forename: Ren-zhi
authors.initials: RZ
authors.lastname: Wang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D066246:ErbB Receptors / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000097:blood*; D008579:Meningioma / Q000097:blood*; D008875:Middle Aged; D011184:Postoperative Period
chemical_list: D014408:Biomarkers, Tumor; D066246:ErbB Receptors