Tissue plasminogen activator for the treatment of intraabdominal abscesses in a neonate.
Fibrinolytic agents have been used successfully in the management of loculated empyema; however, their use in the treatment of intraabdominal abscesses is limited. The authors describe the case of a 4-week-old girl with intraabdominal abscesses secondary to intestinal perforation that were not amenable to percutaneous drainage, but were managed successfully with intracavitary administration of tissue-plasminogen activator. This case represents the first report in a human, in which tissue-plasminogen activator was used to facilitate percutaneous drainage of an intraabdominal abscess. It is also the first time a fibrinolytic agent has been used for this purpose in a child.
Diamond
Ivan R
IR
Division of Pediatric General Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.
Wales
Paul W
PW
Connolly
Bairbre
B
Gerstle
Ted
T
D018784:Abdominal Abscess / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D003968:Diarrhea, Infantile / Q000150:complications; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007077:Ileal Diseases / Q000150:complications / Q000601:surgery; D007082:Ileum / Q000601:surgery; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D007416:Intestinal Perforation / Q000150:complications / Q000601:surgery; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator