Changing trends in pediatric transplantation: 2001 Annual Report of the North American Pediatric Renal Transplant Cooperative Study.
The North American Pediatric Renal Transplant Cooperative Study has collected clinical information on children undergoing a renal transplantation since 1987. This cooperative group now includes over 150 participating medical centers in the United States, Canada, Mexico, and Costa Rica. This report covers the years from 1987 through 2001 and includes data on 7545 renal transplants in 6878 patients. This report demonstrates changing trends in many areas of pediatric transplantation including increasing numbers of African American and Hispanic children receiving transplantation, remarkable improvements in the rate of acute rejection, rejection reversal, and short- and long-term allograft survival. In the most recent cohorts of patients, we now see that 1-yr allograft survival is no different in cadaver donor compared to living donor recipients and in infants compared to all other age groups. However, this analysis also reveals areas of continued challenges including inferior outcomes in African American and adolescent populations, chronic rejection, and the adverse effects of immunosuppression.
Benfield
Mark R
MR
Division of Pediatric Nephrology, University of Alabama at Birmingham, Birmingham, AL, USA.
McDonald
Ruth A
RA
Bartosh
Sharon
S
Ho
P L
PL
Harmon
William
W
D044383:Black People / Q000706:statistics & numerical data; D002648:Child; D003364:Costa Rica; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000706:statistics & numerical data / Q000639:trends*; D015337:Multicenter Studies as Topic; D009656:North America; D012042:Registries; D001741:Black or African American
D007166:Immunosuppressive Agents