Conditional live virus as a novel approach towards a safe live attenuated HIV vaccine.
To control the worldwide spread of HIV, a safe and effective prophylactic vaccine is urgently needed. Studies with the simian immunodeficiency virus demonstrated that a live attenuated virus can be effective as a vaccine, but serious concerns about the safety of such a vaccine virus have arisen. We propose a conditional live virus, of which the replication can be switched on and off at will, as a novel approach for an HIV vaccine.
Das
Atze T
AT
Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands. a.t.das@amc.uva.nl
Zhou
Xue
X
Vink
Monique
M
Klaver
Bep
B
Berkhout
Ben
B
D016915:AIDS Vaccines / Q000009:adverse effects / Q000276:immunology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D004318:Doxycycline / Q000494:pharmacology; D015316:Genetic Therapy; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1 / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D018449:SAIDS Vaccines / Q000276:immunology; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology*
D016915:AIDS Vaccines; D000900:Anti-Bacterial Agents; D018449:SAIDS Vaccines; D014613:Vaccines, Attenuated; D004318:Doxycycline