[New targets for drug therapeutics: receptors for purines and pyrimidines].
Endogenous nucleoside and nucleotide mediate a lot of functions via cell surface P receptors (receptors for purines and pyrimidines) in many organs. Nucleoside and nucleotide have protective roles in the events such as cancer, apoptosis, ischemia, wound healing, osteoporosis, drug toxicity, inflammation and pain. Moreover, the development of selective agonists and antagonists for P1, P2 receptors and P receptor subtypes may provide novel drugs in therapeutic strategies.
Ren
Lei-Ming
LM
Hebei Medical University School of Pharmacy.
Zhang
Miao
M
Yao
Shu-Kun
SK
Zhu
Zhong-Ning
ZN
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D015195:Drug Design; D006801:Humans; D011687:Purines / Q000378:metabolism; D011743:Pyrimidines / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology*; D011983:Receptors, Purinergic / Q000187:drug effects / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology
D011687:Purines; D011743:Pyrimidines; D011956:Receptors, Cell Surface; D011983:Receptors, Purinergic