title: Increased levels of syndecan-1 in serum during acute graft-versus-host disease.
abstract: Acute graft-versus-host disease (GVHD) may affect several organs. Syndecan-1 is a heparan sulfate proteoglycan that can be shed from the surface of most epithelial cells (skin, liver, and gut among others), which are target organs for GVHD. Syndecan-1 was measured in serum samples from 60 patients after allogeneic stem-cell transplantation and was related to the degree of GVHD. Syndecan-1 levels increased in patients who developed acute GVHD but not in patients without GVHD. The difference between groups was significant 3 to 10 weeks after transplantation. The peak level of syndecan-1 in serum correlated with the degree of acute GVHD (r=0.46, P<0.001). Combined, the peak levels of syndecan-1 and soluble interleukin-2 receptor detected patients with acute GVHD (sensitivity 82%, specificity 89%). This study shows that syndecan-1 levels are increased during acute GVHD. Syndecan-1 may be a marker for acute GVHD, especially if combined with determination of soluble interleukin-2 receptor.
authors.affiliation: Division of Pathology, Department of Laboratory Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden. carina.seidel@labmed.ki.se.
authors.forename: Carina
authors.initials: C
authors.lastname: Seidel
authors.forename: Olle
authors.initials: O
authors.lastname: Ringdén
authors.forename: Mats
authors.initials: M
authors.lastname: Remberger
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000628:therapy; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000628:therapy; D011509:Proteoglycans / Q000097:blood*; D012680:Sensitivity and Specificity; D033581:Stem Cell Transplantation; D053668:Syndecan-1; D053667:Syndecans
chemical_list: D015415:Biomarkers; D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508241:SDC1 protein, human; D053668:Syndecan-1; D053667:Syndecans