title: Simvastatin.
abstract: Simvastatin, or (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-3,4,5,6-tetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate, C(25)H(38)O(5), is almost isostructural with lovastatin, and the general conformational features are closely related to those of other reported crystal structures of statins. The only hydrogen bond present facilitates the formation of infinite chains of molecules along the b axis.
authors.affiliation: Department of Solid State Chemistry, Prague Institute of Chemical Technology, Technická 5, 166 28 Prague 6, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Cejka
authors.forename: Bohumil
authors.initials: B
authors.lastname: Kratochvíl
authors.forename: Ivana
authors.initials: I
authors.lastname: Císarová
authors.forename: Alexandr
authors.initials: A
authors.lastname: Jegorov
mesh_terms: D000924:Anticholesteremic Agents / Q000737:chemistry*; D008958:Models, Molecular; D019821:Simvastatin / Q000737:chemistry*
chemical_list: D000924:Anticholesteremic Agents; D019821:Simvastatin