title: Parathyroid hormone gene with bone phenotypes in Chinese.
abstract: Osteoporosis is a common disorder afflicting old people. The parathyroid hormone (PTH) gene is involved in bone remodeling and calcium homeostasis, and has been considered as an important candidate gene for osteoporosis. In this study, we simultaneously tested linkage and/or association of PTH gene with bone mineral density (BMD) and bone mineral content (BMC), two important risk factors for osteoporosis. A sample of 1263 subjects from 402 Chinese nuclear families was used. The families are composed of both parents and at least one healthy daughter aged from 20 to 45 years. All the subjects were genotyped at the polymorphic BstBI site inside the intron 2 of the PTH gene (a nucleotide substitution of G to A at the position +3244). BMD and BMC were measured at the lumbar spine and the hip region via dual-energy X-ray absorptiometry (DXA). Using QTDT (quantitative trait transmission disequilibrium test), we did not find significant results for association or linkage between the PTH gene and BMD or BMC variation at the spine or hip. Our data do not support the PTH gene as a quantitative trait locus (QTL) underlying the bone phenotypic variation in the Chinese population.
authors.affiliation: Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, PR China.
authors.forename: Xiao-Gang
authors.initials: XG
authors.lastname: Zhou
authors.forename: Yao-Zhong
authors.initials: YZ
authors.lastname: Liu
authors.forename: Miao-Xin
authors.initials: MX
authors.lastname: Li
authors.forename: Wei-Xia
authors.initials: WX
authors.lastname: Jian
authors.forename: Shu-Feng
authors.initials: SF
authors.lastname: Lei
authors.forename: Yue-Juan
authors.initials: YJ
authors.lastname: Qin
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhou
authors.forename: Hong-Wen
authors.initials: HW
authors.lastname: Deng
mesh_terms: D000328:Adult; D015519:Bone Density / Q000235:genetics*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002681:China; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000208:ethnology / Q000235:genetics; D010281:Parathyroid Hormone / Q000235:genetics*; D010641:Phenotype; D040641:Quantitative Trait Loci; D011859:Radiography
chemical_list: D010281:Parathyroid Hormone