title: High sensitivity CRP and serum amyloid A as expressions of low grade inflammation do not correlate with bFGF or VEGF.
abstract: High sensitivity CRP (hsCRP) and serum amyloid component A (SAA) are two acute phase proteins that have been shown to be prognostic markers in cardiovascular diseases. Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are two angiogenic growth factors involved in the growth and invasion of solid tumors and hematological malignancies. They also play an important role in cardiovascular and inflammatory diseases. The acute phase response induces the production of angiogenic peptides and angiogenic peptides have also been shown to induce the synthesis of inflammatory cytokines. HsCRP and SAA, bFGF and VEGF in serum and EDTA plasma were measured in samples from 80 human blood donors. There were strong correlations between hsCRP and SAA but there were no significant correlation between hsCRP or SAA and any of the angiogenic peptides. Low-grade inflammation did not induce bFGF or VEGF production.
authors.affiliation: Department of Clinical Chemistry and Pharmacology, University Hospital, Uppsala, Sweden. anders.larsson@clm.uas.lul.se
authors.forename: A
authors.initials: A
authors.lastname: Larsson
authors.forename: L O
authors.initials: LO
authors.lastname: Hansson
mesh_terms: D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000378:metabolism*; D001782:Blood Donors; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D000685:Serum Amyloid A Protein / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D001053:Apolipoproteins; D000685:Serum Amyloid A Protein; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D002097:C-Reactive Protein