title: Evidence of Toscana virus circulation in Umbria: first report.
abstract: To evaluate, for the first time, circulation and clinical expression of Toscana virus (ToSv) in Umbria region we studied: (1) 93 cases of aseptic meningitis and meningoencephalitis admitted to our Department from 1989 to 2001 with negative results for common neurotropic virus; (2) 50 healthy subjects. Specific antibodies (IgM and IgG) anti-TOSv were found in 36.6% of aseptic meningitis, in 6.06% of meningoencephalitis and (IgG) in 16% of healthy subjects.
authors.affiliation: Clinica Malattie Infettive, Policlinico Monteluce, Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy. francisd@unipg.it
authors.forename: D
authors.initials: D
authors.lastname: Francisci
authors.forename: R
authors.initials: R
authors.lastname: Papili
authors.forename: G
authors.initials: G
authors.lastname: Camanni
authors.forename: S
authors.initials: S
authors.lastname: Morosi
authors.forename: N
authors.initials: N
authors.lastname: Ferracchiato
authors.forename: M
authors.initials: M
authors.lastname: Valente
authors.forename: M G
authors.initials: MG
authors.lastname: Ciufolini
authors.forename: F
authors.initials: F
authors.lastname: Baldelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D007558:Italy / Q000453:epidemiology; D008297:Male; D008581:Meningitis / Q000097:blood* / Q000453:epidemiology / Q000821:virology; D008590:Meningoencephalitis / Q000097:blood / Q000453:epidemiology / Q000821:virology; D008875:Middle Aged; D029301:Sandfly fever Naples virus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D016036:Seroepidemiologic Studies
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M