[Psoriasis: pathogenesis and treatment].
Psoriasis is a T-cell mediated disease. Its pathogenesis is linked to the activation of T-cells by antigen-presenting cells and secretion of cytokines able to modulate keratinocyte proliferation and differentiation. Antigens involved in psoriasis triggering are unidentified. Several new biological immunomodulatory treatments able to block T-cell activation and epidermal cells modifications are currently investigated.
Heenen
M
M
Service de Dermatologie, Hôpital Erasme, U.L.B.
D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D011565:Psoriasis / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology