[Optimal recurrence prevention of iodine deficiency related goiter after thyroid gland operation. A prospective clinical study].
In summary the data of our study show: (1) Sonographically determined thyroid volume of patients with euthyroidism after surgery is found to be significantly lower with a combination therapy (iodide 150 microgram +Levothyroxine 75 microgram) compared to patients with iodide monotherapy (200 microgram). (2) Thyroid volume of patients with hypothyroidism after surgery is found to be significantly lower during a combination therapy (150 microgram iodide + 75 microgram L-thyroxine) compared to patients with a Levothyroxine monotherapy.  (3) Patients with hypothyroidism and Levothyroxine monotherapy, however present with a significant increase of thyroid volume after surgery. (4) Urinary iodide excretion in the treatment groups with iodide or combination therapy increases significantly during therapy, however, patients with Levothyroxine monotherapy do not show changes. (5) Thyroid function is well stabilized in all treatment groups with adequate controls and adjustment of Levothyoxine dosage.  There data clearly demonstrate that the combination therapy with Levothyoxine and iodide significantly improves prophylaxis of goiter recurrence.
Schumm-Draeger
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3, Medizinische Klinik, Abteilung Endokrinologie, Diabetologie und Angiologie, Klinikum München-Bogenhausen, Englschalkinger Strasse 77, 81925 München. schumm-draeger@extern.lrz-münchen.de
Encke
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A
Usadel
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D000328:Adult; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006043:Goiter, Endemic / Q000517:prevention & control* / Q000601:surgery; D006044:Goiter, Nodular / Q000517:prevention & control* / Q000601:surgery; D006801:Humans; D007037:Hypothyroidism / Q000517:prevention & control; D007455:Iodine / Q000008:administration & dosage* / Q000172:deficiency*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D055502:Secondary Prevention; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000008:administration & dosage*; D016896:Treatment Outcome
D007455:Iodine; D013974:Thyroxine