[Significance of the unbalanced expression of Th1/Th2 type cytokines in human glioma].
OBJECTIVE
To study the significance of the unbalanced expression of Th1/Th2 type cytokines in human glioma.


METHODS
The gene expressions of Th1/Th2 type cytokines in 62 specimens of human glioma tissues, 4 glioma cell lines, peripheral blood mononuclear cell (PBMC) of 15 glioma patients, 5 specimens of normal adult brain tissue and 5 brain meningioma tissues were detected by semiquantitative reverse transcription polymerase chain reaction. IFN-gamma and IL-2 represent Th1 type cytokines. IL-4, IL-6, IL-10 and IL-13 represent Th2 type cytokines.


RESULTS
There were obviously predominant expression of Th2 type cytokines in glioma cell lines (P < 0.01) and specimens of human glioma tissues (P < 0.01). The tendency of distinct expression of Th2 type cytokines in PBMC was also existent. There wasn't obvious discrepancy of the expression of two type cytokines in normal adult brain tissues and meningioma tissues.


CONCLUSIONS
It is likely that the switching of Th1/Th2 type cytokines in gliomas as predominant expression of Th2 type cytokine genes is related to the origination of gliomas and the evasion of glioma cells from immune surveillance.
Hu
Y S
YS
Department of Neurosurgery, Second Hospital, Shandong University, Jinan 250033, China. hysh69@hotmail.com
Zhang
Q L
QL
Tian
Z G
ZG
Wei
H M
HM
Li
G
G
Pang
Q
Q
Feng
J B
JB
Xu
X Q
XQ
Wang
C W
CW
Sun
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000276:immunology* / Q000378:metabolism; D045744:Cell Line, Tumor; D002648:Child; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D005910:Glioma / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007378:Interleukins / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism
D016207:Cytokines; D007378:Interleukins