title: Effectiveness of a combination of platelet-rich plasma, bovine porous bone mineral and guided tissue regeneration in the treatment of mandibular grade II molar furcations in humans.
abstract: OBJECTIVE
  A combination of platelet-rich plasma (PRP), bovine porous bone mineral (BPBM) and guided tissue regeneration (GTR) has been shown to be effective as regenerative treatment for intrabony periodontal defects. The purpose of this study was to evaluate the effectiveness of PRP, BPBM and GTR used in combination as regenerative treatment for grade II molar furcation defects in humans.
  
  
  METHODS
  Using a split-mouth design, a total of 52 grade II mandibular molar furcation defects were treated either with PRP/BPBM/GTR (experimental group, n=26) or with an open flap debridement (control group, n=26). The primary outcomes evaluated in this study included changes in pocket depth, attachment level and re-entry bone levels (horizontal and vertical) between baseline and 6 months postoperatively.
  
  
  RESULTS
  The results showed that the experimental group presented with significantly greater pocket reduction (4.07+/-0.33 mm for experimental and 2.49+/-0.38 mm for control sites), gain in clinical attachment (3.29 +/- 0.42 mm for experimental and 1.68+/-0.31 mm for control sites), vertical defect fill (2.56+/- 0.36 mm for experimental and -0.19+/-0.02 for control sites) and horizontal defect fill (2.28+/-0.33 mm for experimental and 0.08+/-0.02 mm for control sites) than the control group.
  
  
  CONCLUSIONS
  It was concluded that the PRP/BPBM/GTR combined technique is an effective modality of regenerative treatment for mandibular grade II furcation defects. Further studies are necessary to elucidate the role played by each component of the combined therapy in achieving these results.
authors.affiliation: Division of Associated Clinical Specialties, University of California, School of Dentistry, Los Angeles, CA, USA.
authors.forename: Vojislav
authors.initials: V
authors.lastname: Lekovic
authors.forename: Paulo M
authors.initials: PM
authors.lastname: Camargo
authors.forename: Michael
authors.initials: M
authors.lastname: Weinlaender
authors.forename: Nikola
authors.initials: N
authors.lastname: Vasilic
authors.forename: Zoran
authors.initials: Z
authors.lastname: Aleksic
authors.forename: E Barrie
authors.initials: EB
authors.lastname: Kenney
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D001792:Blood Platelets; D001857:Bone Matrix / Q000637:transplantation*; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D017823:Furcation Defects / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008903:Minerals / Q000627:therapeutic use*; D010983:Plateletpheresis; D016745:Root Planing
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals