title: Stimulation of mouse resistance to bacterial infection with muramyl dipeptide glycoside.
abstract: We studied the capacity of 9 new muramyl dipeptide glycosides to stimulate mouse resistance to experimental sepsis induced by intraperitoneal injection of salmonella typhimurium culture. Preventive intraperitoneal injections of muramyl dipeptide beta-glycosides better improved survival of infected animals compared to the original (unmodified) muramyl dipeptide and muramyl dipeptide alpha-glycosides. The most effective drug muramyl dipeptide beta-heptylglycoside injected during sepsis development also reduced animal mortality, decreased bacterial contamination of the viscera, and increased phagocytic activity of peritoneal macrophages in infected animals.
authors.affiliation: Laboratory of Cellular Immunopathology and Biotechnology, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow. kalyuzhin@mtu-net.ru
authors.forename: O V
authors.initials: OV
authors.lastname: Kalyuzhin
authors.forename: N G
authors.initials: NG
authors.lastname: Kalina
authors.forename: A F
authors.initials: AF
authors.lastname: Bashtanenko
authors.forename: M V
authors.initials: MV
authors.lastname: Shkalev
authors.forename: F N
authors.initials: FN
authors.lastname: Kuzovlev
authors.forename: V V
authors.initials: VV
authors.lastname: Kalyuzhin
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D001424:Bacterial Infections / Q000276:immunology*; D007113:Immunity, Innate / Q000502:physiology*; D017737:Macrophages, Peritoneal / Q000276:immunology / Q000378:metabolism; D051379:Mice; D012486:Salmonella typhimurium / Q000276:immunology / Q000378:metabolism; D018805:Sepsis; D015996:Survival Rate
chemical_list: D000119:Acetylmuramyl-Alanyl-Isoglutamine