Synthetic studies on nonthrombogenic biomaterials 14: synthesis and characterization of poly(ether-urethane) bearing a Zwitterionic structure of phosphorylcholine on the surface.
A new Zwitterionic compound of the phosphorylcholine analogue, 4-hydroxylbutyl phosphorylcholine (HBPC), was synthesized and characterized. HBPC was chemically tethered onto the surface of poly(ether-urethane) (PEU) films with hexamethylene diisocyanate (HDI) as a coupling agent. The existence of a phosphorylcholine structure on the PEU surface was demomstrated by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR), X-ray photoelectron spectroscopy (XPS) and water contact angle measurements. The nonthrombogenicity of the modified films was evaluated by platelet-rich plasma (PRP) assay. The results showed that films grafted with HBPC have excellent platelet adhesion resistance.
Yang
Z M
ZM
Research Center of Surface Interface Science and Technology, Nanjing University, Nanjing 210093, P.R. China.
Wang
L
L
Yuan
J
J
Shen
J
J
Lin
S C
SC
D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D010767:Phosphorylcholine / Q000737:chemistry*; D010974:Platelet Aggregation; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000737:chemistry*; D013499:Surface Properties; D013927:Thrombosis
D001672:Biocompatible Materials; D011140:Polyurethanes; D010767:Phosphorylcholine