title: Multinucleation of the sodC-deficient Dictyostelium discoideum.
abstract: The cellular slime mold Dictyostelium discoideum expresses three genes (sodA, sodB and sodC) encoding the extracellular Cu/Zn superoxide dismutases. Following H(2)O(2) treatment, the expression of sodA and sodB increased while that of sodC decreased. The sodC null strain formed multinucleate cells in a shaking culture. These results suggest that sodC plays a unique role in Dictyostelium discoideum.
authors.affiliation: Division of Bioengineering, Faculty of Engineering, Toyama University, Toyama, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tsuji
authors.forename: Yuya
authors.initials: Y
authors.lastname: Akaza
authors.forename: Shogo
authors.initials: S
authors.lastname: Nakamura
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Kodaira
authors.forename: Hiro
authors.initials: H
authors.lastname: Yasukawa
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004023:Dictyostelium / Q000166:cytology / Q000235:genetics* / Q000378:metabolism*; D029968:Escherichia coli Proteins; D017125:Genes, Protozoan / Q000187:drug effects; D015726:Giant Cells / Q000166:cytology / Q000187:drug effects / Q000201:enzymology*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D017421:Sequence Analysis; D013482:Superoxide Dismutase / Q000096:biosynthesis / Q000172:deficiency* / Q000235:genetics*
chemical_list: D029968:Escherichia coli Proteins; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase; C116114:sodC protein, E coli