Relationship between circulating E-selectin, DD genotype of angiotensin-converting-enzyme, and cardiovascular damage in central obese subjects.
Fifty-six young central obese patients were investigated to evaluate relationships between soluble E-selectin (sE-S), angiotensin-converting enzyme (ACE) gene polymorphism, left ventricular function and structure, and carotid morphology by determination of sE-S and ACE genotypes. Our results indicated that central obese subjects with concomitant higher levels of sE-S and ACE DD genotype may be characterized by early cardiovascular alterations and then considered a particular subset of subjects at higher risk of cardiovascular disease.
Licata
Giuseppe
G
Department of Internal Medicine, University of Palermo, Palermo, Italy.
Di Chiara
Tiziana
T
Licata
Anna
A
Triolo
Giovanni
G
Argano
Christiano
C
Pinto
Antonio
A
Parrinello
Gaspare
G
Corrao
Salvatore
S
Duro
Giovanni
G
Scaglione
Rosario
R
D000328:Adult; D000483:Alleles; D001161:Arteriosclerosis / Q000235:genetics / Q000473:pathology; D001794:Blood Pressure; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000473:pathology*; D002339:Carotid Arteries / Q000502:physiology; D019040:E-Selectin / Q000378:metabolism*; D004452:Echocardiography; D005260:Female; D005838:Genotype; D005951:Glucose Tolerance Test; D006321:Heart / Q000502:physiology; D006439:Hemodynamics / Q000235:genetics / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood; D007527:Isoenzymes / Q000235:genetics* / Q000378:metabolism*; D008297:Male; D009765:Obesity / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics* / Q000378:metabolism*; D012044:Regression Analysis; D012307:Risk Factors
D019040:E-Selectin; D007328:Insulin; D007527:Isoenzymes; D007703:Peptidyl-Dipeptidase A