[Change of 5-fluorouracil penetration in blood-pancreatic barrier of rats after high-dose radiotherapy].
OBJECTIVE
The high-dose intraoperative radiotherapy has become an important therapy to control local recur of pancreatic carcinoma. But the relevant effect of high-dose radiotherapy on chemotherapy is not clear now.


METHODS
We studied the effect of high-dose radiotherapy to the penetration of 5-FU (5-Fluorouracil) in blood-pancreatic barrier of rats after the pancreatic region of the rats had treated with 10(Gy) external beam radiotherapy, the penetration ratio (PR) of 5-FU in the pancreatic tissue was investigated with HPLC assay.


RESULTS
We found the PR increased with the time processing. And reached the peak on the 6th day, (PR = 0.8300 +/- 0.1662, P < 0.05). Then, the PR began to descend and was 0.7028 on the 10th day. But it was still significantly higher than control group (P < 0.05).


CONCLUSIONS
After the treatment of high-dose radiotherapy, in addition to chemotherapy on the 4th day, and finished the course on the 10th day, the effect of radiotherapy may improve chemotherapy significantly.
Kang
W
W
Department of Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. Kangweiming@Chinaren.com
Zhao
Y
Y
Tao
W
W
Cai
L
L
Zhu
Y
Y
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002199:Capillary Permeability / Q000528:radiation effects*; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male; D010179:Pancreas / Q000378:metabolism* / Q000528:radiation effects; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D051381:Rats; D017208:Rats, Wistar
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil