[IL-15 and autoimmune disease].
This review attempts to define the relationship between IL-15 and autoimmune disease (AID) from IL-15's tissue distribution, expression regulation and biologic function. Meanwhile, five IL-15 dysregulation-related AIDs and four IL-15/IL-15R-targeted AID therapies are described.
Li
Wen-xin
WX
Medical Biotechnology Institute, Soochow University, Suzhou 215007, China.
Zhang
Xue-guang
XG
D000818:Animals; D001327:Autoimmune Diseases / Q000378:metabolism*; D006801:Humans; D019409:Interleukin-15 / Q000378:metabolism*; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism*; D009103:Multiple Sclerosis / Q000378:metabolism
D019409:Interleukin-15