title: Magnetic resonance imaging and spectroscopy in a patient with treated methylmalonic acidemia.
abstract: Magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (proton MRS) findings before and after carnitine therapy in a patient with methylmalonic acidemia (MMA) are evaluated. The hyperintensity on T2-weighted image and diffusion-weighted image and the decreased apparent diffusion coefficient of bilateral basal ganglia were normalized in parallel with normalization of the elevated lactate levels and the decreased N-acetyl-aspartate levels, corresponding to improvement of clinical symptoms. MRI and proton MRS may serve as a suitable, noninvasive modality for monitoring treated MMA.
authors.affiliation: Department of Radiology, University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima, Japan. mayumi@clin.med.tokushima-u.ac.jp
authors.forename: Mayumi
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Harada
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsuzaki
authors.forename: Sonoka
authors.initials: S
authors.lastname: Hisaoka
authors.forename: Hiromu
authors.initials: H
authors.lastname: Nishitani
authors.forename: Kenji
authors.initials: K
authors.lastname: Mori
mesh_terms: D001479:Basal Ganglia / Q000473:pathology*; D020739:Brain Diseases, Metabolic, Inborn / Q000188:drug therapy / Q000473:pathology*; D002331:Carnitine / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008764:Methylmalonic Acid / Q000032:analysis*
chemical_list: D008764:Methylmalonic Acid; D002331:Carnitine