Antinociceptive effects of supraspinal rat cart (55-102) peptide in mice.
We investigated the effects of rat cocaine- and amphetamine-regulated transcript CART (55-102) after i.c.v. administration in mouse models of acute and persistent pain. CART was not active in the tail-flick or PPQ tests. It increased the latency to paw licking in the hot-plate test but only at doses that impaired motor function. CART produces antinociception in the formalin test in both phases. Our results suggest that CART is involved in supraspinal pain transmission.
Damaj
M Imad
MI
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298-0613, USA. mdamj@hsc.vcu.edu
Martin
Billy R
BR
Kuhar
Michael J
MJ
D000700:Analgesics; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde; D006358:Hot Temperature; D007276:Injections, Intraventricular; D051379:Mice; D008813:Mice, Inbred ICR; D009419:Nerve Tissue Proteins; D010147:Pain Measurement / Q000187:drug effects; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
D000700:Analgesics; D005557:Formaldehyde; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; C428723:cocaine- and amphetamine-regulated transcript protein (55-102); D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein