title: Flavonoids and isoflavonoids with antiplasmodial activities from the root bark of Erythrina abyssinica.
abstract: From the root bark of Erythrina abyssinica a new pterocarpene [3-hydroxy-9-methoxy-10-(3,3-dimethylallyl)pterocarpene] and a new isoflav-3-ene [7,4'-dihydroxy-2',5'-dimethoxyisoflav-3-ene] were isolated. In addition, the known compounds erycristagallin, licoagrochalcone A, octacosyl ferulate and triacontyl 4-hydroxycinnamate were identified. The structures were determined on the basis of spectroscopic evidence. The crude extract and the flavonoids and isoflavonoids obtained from the roots of this plant showed antiplasmodial activities.
authors.affiliation: Department of Chemistry, University of Nairobi, Nairobi, Kenya. ayenesew@uonbi.ac.ke
authors.forename: Abiy
authors.initials: A
authors.lastname: Yenesew
authors.forename: Solomon
authors.initials: S
authors.lastname: Derese
authors.forename: Beatrice
authors.initials: B
authors.lastname: Irungu
authors.forename: Jacob O
authors.initials: JO
authors.lastname: Midiwo
authors.forename: Norman C
authors.initials: NC
authors.lastname: Waters
authors.forename: Pamela
authors.initials: P
authors.lastname: Liyala
authors.forename: Hoseah
authors.initials: H
authors.lastname: Akala
authors.forename: Matthias
authors.initials: M
authors.lastname: Heydenreich
authors.forename: Martin G
authors.initials: MG
authors.lastname: Peter
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology; D004895:Erythrina / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D005419:Flavonoids