[Antiischemic efficacy of trimetazidine in patients with intermittent claudication and effort angina].
Male patients (n=42) with atherosclerosis obliterans and stage IIA-III ischemia of lower extremities combined with class II-III angina pectoris were divided into 2 groups. Patients of group 1 (n=21) were given simvastatin (10-20 mg/day), clopidogrel (75 mg/day) and trimetazidine (60 mg/day) for 6 months, those of group 2 - simvastatin and clopidogrel also for 6 months. Statistically significant decreases of frequency of attacks of angina, nitroglycerine consumption and increases of walking distance occurred only in group 1.
Syrkin
A L
AL
Moskovskaia meditsinskaia akademiia im. I. M. Sechenova, Moskva.
Artiukhina
E G
EG
Kanorskiĭ
S G
SG
Chuntyzheva
M M
MM
D000368:Aged; D000787:Angina Pectoris / Q000150:complications / Q000188:drug therapy*; D001161:Arteriosclerosis / Q000150:complications / Q000188:drug therapy*; D001162:Arteriosclerosis Obliterans / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007383:Intermittent Claudication / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014292:Trimetazidine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents; D014292:Trimetazidine