title: [A 3-amino acid deletion of apolipoprotein E found in 3 Chinese lipoprotein glomerulopathy patients].
abstract: OBJECTIVE
  To analyze the mutation of apolipoprotein E (apoE) gene so as to investigate the pathogenesis of lipoprotein glomerulopathy (LPG).
  
  
  METHODS
  Restriction fragment length polymorphism methods was used to analyze the apoE genotypes of three Chinese patients with LPG and 3 of their relatives. Automated DNA sequencing was performed upon their apoE genes.
  
  
  RESULTS
  A 9-bp deletion in exon 4 of apoE, resulting in a 3-amino acid deletion (residues 142-144-0) was identified.
  
  
  CONCLUSIONS
  A 3-amino acid deletion of apoE has been discovered which is associated with LPG.
authors.affiliation: Department of Nephrology, First Hospital of Peking University, Beijing 100034, China.
authors.forename: Yu-qing
authors.initials: YQ
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Shi-le
authors.initials: SL
authors.lastname: Zhu
authors.forename: Wan-zhong
authors.initials: WZ
authors.lastname: Zou
authors.forename: Mei
authors.initials: M
authors.lastname: Wang
authors.forename: Zhang-suo
authors.initials: ZS
authors.lastname: Liu
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000595:Amino Acid Sequence; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics* / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion
chemical_list: D001057:Apolipoproteins E