title: Early amidation approach to 3-[(4-amido)pyrrol-2-yl]-2-indolinones.
abstract: A new synthesis of 3-[(4-amido)pyrrol-2-yl]-2-indolinones has been developed, where the amide side chain was installed prior to pyrrole formation. This strategy precludes the need to use any coupling reagents to install the amide side chain. This process includes a zinc-free alternative to the Knorr pyrrole synthesis.
authors.affiliation: Chemical Research and Development, Pfizer Inc, 0200-1500-91-201, 7000 Portage Road, Kalamazoo, Michigan 49001, USA.
authors.forename: Jerad M
authors.initials: JM
authors.lastname: Manley
authors.forename: Monica J
authors.initials: MJ
authors.lastname: Kalman
authors.forename: Brian G
authors.initials: BG
authors.lastname: Conway
authors.forename: Cynthia C
authors.initials: CC
authors.lastname: Ball
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Havens
authors.forename: Rajappa
authors.initials: R
authors.lastname: Vaidyanathan
mesh_terms: D000577:Amides / Q000138:chemical synthesis; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D015032:Zinc
chemical_list: D000577:Amides; D007202:Indicators and Reagents; D007211:Indoles; D011758:Pyrroles; D015032:Zinc