Allylmagnolol, a novel magnolol derivative as potent antioxidant.
We reported the discovery of potent antioxidants based on magnolol, a naturally occurring biphenolic obtained from the bark of Magnolia officinalis. The allylmagnolols 3a,b were synthesized via O-alkylation of the biphenols followed by Claisen rearrangement. In-vitro using enhanced chemiluminescence (CL) and flow cytometric assays in whole cells revealed that both 3a and 3b displayed promising free radical scavenging effects in PMA- and LPS-stimulated models as compared with magnolol. Further DNA labeling analysis for cytotoxicity indicated that these analogues show no cytotoxic effects for the scavenging of the oxygen-derived free radicals under PMA-stimulated concentrations. The results from 3,3'-bisallylmagnolol (3b) suggested that the naturally occurring constituent was suitable to be a lead compound for the development of potential antioxidants for certain diseases.
Li
Chi-Yuan
CY
Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, 325, Chenggung Road, Section 2, 114, Taipei, Taiwan.
Wang
Yvonne
Y
Hu
Ming-Kuan
MK
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000032:analysis; D017705:Lignans; D008163:Luminescent Measurements; D009504:Neutrophils / Q000737:chemistry
D000975:Antioxidants; D001713:Biphenyl Compounds; D017705:Lignans; C483259:allylmagnolol; C005498:magnolol; D006861:Hydrogen Peroxide