title: [Effectiveness of syndromic approach for management of urethral discharge in Senegal].
abstract: The World Health Organization has proposed the syndromic approach for management of sexually transmissible diseases (STD) in countries where diagnostic laboratory tests are not consistently available. The purpose of this study was to evaluate the effectiveness of this approach for treatment of ureteral discharge in Senegal. Twenty seven men presenting ureteral discharge underwent two-week treatment using a combination of cotrimoxazole plus tetracycline for suspected gonococcal and a chlamydial infections. Ureteral samples were collected before and after treatment to detect Neisseria gonorrhoeae by culture and Chlamydia trachomatis by direct immunofluorescence and ELISA. Results demonstrated successful treatment of all patients presenting gonococcal and chlamydial infections i.e. 84.6% of cases. Neither germ was detected in 15.4% of cases. Before treatment, Neisseria gonorrhoeae, Chlamydia trachomatis or both were found respectively in 53.9%, 5.1% and 25.6% of samples respectively. Based on these findings we conclude that the syndromic approach was effective in 84.6% of cases but treatment was in adequation with STD biologically documented only with 25.6% of cases.
authors.affiliation: Laboratoire de Pharmacologie et de Physiologie, Faculté de Médecine, de Pharmacie et d'Odonto-Stomatologie, Université Cheikh Anta DIOP, BP 5005, Dakar, Sénégal. ctdieye@yahoo.fr
authors.forename: A M
authors.initials: AM
authors.lastname: Dieye
authors.forename: N G
authors.initials: NG
authors.lastname: Samb
authors.forename: A
authors.initials: A
authors.lastname: Ba
authors.forename: M
authors.initials: M
authors.lastname: Tardy
authors.forename: K
authors.initials: K
authors.lastname: Seck
authors.forename: A S
authors.initials: AS
authors.lastname: Wade
authors.forename: M
authors.initials: M
authors.lastname: Gueye
authors.forename: M
authors.initials: M
authors.lastname: N'Diaye
authors.forename: G Y
authors.initials: GY
authors.lastname: Sy
authors.forename: B
authors.initials: B
authors.lastname: Faye
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002690:Chlamydia Infections / Q000188:drug therapy; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D004359:Drug Therapy, Combination; D006069:Gonorrhea / Q000188:drug therapy; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D012675:Senegal; D013577:Syndrome; D013752:Tetracycline / Q000008:administration & dosage; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage; D014522:Urethral Diseases / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D013752:Tetracycline