In B-cell chronic lymphocytic leukemias, 7q21 translocations lead to overexpression of the CDK6 gene.
Hayette
Sandrine
S
Tigaud
Isabelle
I
Callet-Bauchu
Evelyne
E
Ffrench
Martine
M
Gazzo
Sophie
S
Wahbi
Kamal
K
Callanan
Mary
M
Felman
Pascale
P
Dumontet
Charles
C
Magaud
Jean-Pierre
JP
Rimokh
Ruth
R
D000368:Aged; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D051361:Cyclin-Dependent Kinase 6; D018844:Cyclin-Dependent Kinases / Q000096:biosynthesis / Q000235:genetics*; D015973:Gene Expression Regulation, Leukemic; D015321:Gene Rearrangement; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic / Q000235:genetics
C495911:CDK6 protein, human; D051361:Cyclin-Dependent Kinase 6; D018844:Cyclin-Dependent Kinases