title: Use of functional analysis methodology in the evaluation of medication effects.
abstract: The atypical antipsychotic medication risperidone was evaluated using a double-blind, placebo-controlled design in the treatment of destructive behavior in two individuals with autism. Pre-medication functional analyses indicated that destructive behavior was maintained by escape from demands, attention, or access to tangible items. For both individuals, destructive behavior during the demand condition was significantly reduced during the medication phases, whereas destructive behavior continued to occur to obtain tangible items (Reggie) and attention (Sean). In addition, there appeared to be a differential effect of the medication on self-injurious behavior (SIB) versus aggression for Sean. Results of the study demonstrate how functional analysis may provide information on those conditions and behaviors that are most likely to be affected by a specific medication.
authors.affiliation: University of Kansas, Lawrence, Kansas 66045-7555, USA.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Crosland
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Zarcone
authors.forename: Steven E
authors.initials: SE
authors.lastname: Lindauer
authors.forename: Maria G
authors.initials: MG
authors.lastname: Valdovinos
authors.forename: Troy J
authors.initials: TJ
authors.lastname: Zarcone
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Hellings
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Schroeder
mesh_terms: D000328:Adult; D000374:Aggression / Q000187:drug effects; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000188:drug therapy; D001321:Autistic Disorder / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D006801:Humans; D008297:Male; D018967:Risperidone / Q000008:administration & dosage / Q000627:therapeutic use*; D016728:Self-Injurious Behavior / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone