Haplotype blocks and linkage disequilibrium in the human genome.
There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans and other species. Characterizing LD is of central importance for gene-mapping studies and can provide insights into the biology of recombination and human demographic history. Here, we review recent developments in this field, including the recently proposed 'haplotype-block' model of LD. We describe some of the recent data in detail and compare the observed patterns to those seen in simulations.
Wall
Jeffrey D
JD
Department of Human Genetics, The University of Chicago, 920 East 58th Street, CLSC 507, Chicago, Illinois 60637, USA. jwall@genetics.bsd.uchicago.edu
Pritchard
Jonathan K
JK
D002874:Chromosome Mapping; D015894:Genome, Human; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D011995:Recombination, Genetic