Attempt to establish an experimental animal model of moyamoya disease using immuno-embolic material--histological changes of the arterial wall resulting from immunological reaction in cats.
In this study, we investigated the relationship between intimal thickening of the internal carotid artery (ICA) and immunological reaction, and between occlusion of the ICA and development of basal collateral vessels in moyamoya disease. Rod-shaped lactic acid-glycolic acid copolymer (LGA-50) and N-acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide: MDP), and immuno-embolic material, were injected into cats unilaterally via the common carotid artery. Histological changes of duplication of the internal elastic lamina could be seen mainly in the terminal portion of the ICA in the animals injected with rod-shaped LGA-50 containing MDP. No angiographic changes were seen in any of the animals. These findings suggest that the immunological reaction induced by MDP caused histological changes in the intima of the ICA similar to those observed in moyamoya disease. This experimental study, however, could not clarify the development of the basal collateral vessels.
Kamata
Ichiro
I
Department of Neurological Surgery, Okayama University Medical School, Okayama 700-8558 Japan. Kamata@kousei-hp.or.jp
Terai
Yoshinori
Y
Ohmoto
Takashi
T
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage / Q000276:immunology; D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D017536:Carotid Artery, Common; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D002415:Cats; D002533:Cerebral Angiography; D004195:Disease Models, Animal; D004338:Drug Combinations; D007269:Injections, Intra-Arterial; D019344:Lactic Acid / Q000008:administration & dosage; D009072:Moyamoya Disease / Q000139:chemically induced* / Q000473:pathology*; D011100:Polyglycolic Acid / Q000008:administration & dosage; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000008:administration & dosage; D017539:Tunica Intima / Q000473:pathology
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D000119:Acetylmuramyl-Alanyl-Isoglutamine