The combined treatment with taurine and niacin blocks the bleomycin-induced activation of nuclear factor-kappaB and lung fibrosis.
Giri
Shri N
SN
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA.
D000818:Animals; D001483:Base Sequence; D001761:Bleomycin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D015153:Blotting, Western; D001992:Bronchoalveolar Lavage Fluid; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D017931:DNA Primers; D004195:Disease Models, Animal; D024202:Electrophoretic Mobility Shift Assay; D006909:Hydroxyproline / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism*; D009525:Niacin / Q000008:administration & dosage / Q000494:pharmacology*; D011658:Pulmonary Fibrosis / Q000378:metabolism / Q000517:prevention & control*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013654:Taurine / Q000008:administration & dosage / Q000494:pharmacology*
D016207:Cytokines; D017931:DNA Primers; D016328:NF-kappa B; D001761:Bleomycin; D013654:Taurine; D009525:Niacin; D006909:Hydroxyproline