Study of the relationship between psoriasis and the polymorphic site C677T of methylenetetrahydrofolate reductase.
OBJECTIVE
In order to investigate 5,10-methylenetetrahydrofolate reductase (MTHFR)'s polymorphic changes in psoriasis vulgaris.


METHODS
We detected mutation of site C677V of MTHFR in 39 psoriastics by PCR-RFLP.


RESULTS
Genotype frequencies of the psoriastics were C/C=20.15%, C/T=48.72% and T/T=30.77%; the allelic frequencies were C=0.4487 and T=0.5513. Homozygous mutant (TT) of the psoriastics was significantly different from the normal control group by X2 test.


CONCLUSIONS
C677V mutant of MTHFR might be related with psoriasis.
Baiqiu
W
W
Department of Medical Genetics, Harbin Medical University, Harbin 150086.
Songbin
F
F
Guiyin
Z
Z
Pu
L
L
D005787:Gene Frequency; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D017354:Point Mutation; D012150:Polymorphism, Restriction Fragment Length; D011565:Psoriasis / Q000201:enzymology / Q000235:genetics*
D042965:Methylenetetrahydrofolate Reductase (NADPH2)