title: [Amiodarone-induced keratopathy].
abstract: Amiodarone is an iodinated benzofuran derivate class III antiarrhythmic that is a highly effective agent for the prophylaxis and treatment of various cardiac arrhythmias. Amiodarone induced corneal deposits are the most common reversible side effects (70-100%) in humans. This study was conducted to determine ocular effects of long-term therapy with amiodarone. We studied 298 patients who received oral amiodarone. The patients were 146 males and 152 females (mean age 48,0+/-0,8 years). During follow-up for 1-122 months (mean 27,3+/-1,5 months) signs of keratopathy were found in 280 patients (93,9%). Severity of keratopathy depended on cumulative drug dose and duration of administration. Neither type of deposits impaired visual activity, and their presence was not considered as indication for interruption of amiodarone treatment. Ophthalmological monitoring of long-term oral amiodarone therapy did not reveal other ocular side effects.
authors.forename: D I
authors.initials: DI
authors.lastname: Reĭngardiene
authors.forename: A P
authors.initials: AP
authors.lastname: Azaravichiene
authors.forename: I I
authors.initials: II
authors.lastname: Vashkeliene
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D003316:Corneal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D013997:Time Factors; D014792:Visual Acuity
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone