Delayed gastric emptying after pancreatoduodenectomy.
With pylorus-preserving pancreatoduodenectomy (PPPD) the goal is to reduce long-term morbidities such as gastric dumping, marginal ulceration or bile-reflux gastritis. Compared with te classical Whipple procedure, PPPD is affected by an equal postoperative morbidity but is known to induce delayed gastric emptying (DGE). It is   difficult to evaluate the true incidence of DGE after  PPPD (from 5 to 50% according to the literature). Early and low doses of erythromycin in the postoperative period could prevent the onset of  DGE and the administration of cisapride 15 mg/day improves gastric emptying up to 6 months after PPPD.
Closset
J
J
Medicosurgical Department of gastro-enterology, ULB-Erasme Hospital, Brussels, Belgium.
Gelin
M
M
D020117:Cisapride / Q000494:pharmacology; D005746:Gastric Emptying / Q000187:drug effects; D005765:Gastrointestinal Agents / Q000494:pharmacology; D005772:Gastrointestinal Transit; D006801:Humans; D016577:Pancreaticoduodenectomy / Q000009:adverse effects*
D005765:Gastrointestinal Agents; D020117:Cisapride