[Recent advances in islet transplantation and pancreatic stem cell research].
This paper reviewed recent advances in pancreatic islet transplantation research, including islet isolation, purification, culture, cryopreservation and immunoisolation. Latest progresses in induction of pancreatic stem cell and embryonic stem cell to differentiate into insulin-producing islets were also introduced. On the basis of the present situation and future development of islet transplantation-based therapies for diabetes, the author thought that allogeous islet transplantation is a main choice for type I diabetes today and pancreatic stem cell transplantation for tomorrow.
Guo
Xi-min
XM
Tissue Engineering Research Center, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China. guoxim@sohu.com
Wang
Chang-yong
CY
D000818:Animals; D002469:Cell Separation; D002478:Cells, Cultured; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000379:methods; D033581:Stem Cell Transplantation