Molecular epidemiology of Haemophilus influenzae type b isolated from children with clinical cases of conjugate vaccine failures.
We analyzed eight invasive Haemophilus influenzae strains isolated from individual children vaccinated appropriately for their ages. Five of the strains were type b and three were nontypeable strains. Children infected with nontypeable strains had a protective level of anti-H. influenzae type b antibodies, while only one of the children whose cases represented true vaccine failure did.
Campos
José
J
Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ministry of Health, Madrid, Spain. jcampos@iscii.es
Aracil
Belén
B
Román
Federico
F
Pérez-Vázquez
María
M
D002675:Child, Preschool; D015658:HIV Infections / Q000150:complications; D006192:Haemophilus Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D018073:Haemophilus Vaccines / Q000627:therapeutic use*; D019741:Haemophilus influenzae type b / Q000145:classification / Q000235:genetics*; D006801:Humans; D007223:Infant; D017720:Molecular Epidemiology; D010802:Phylogeny; D012307:Risk Factors; D017211:Treatment Failure; D018074:Vaccines, Conjugate / Q000627:therapeutic use*
D018073:Haemophilus Vaccines; D018074:Vaccines, Conjugate