title: [Thyroid gland ultrasound screening (Papillon Initiative). Report of 15 incidentally detected thyroid cancers].
abstract: In the framework of the Thyroid initiative Papillon 2001 - 2002 thyroid nodules and sonographically detectable focal lesions with a diameter more than 5 mm were verified in 23.1% of  64.123 persons without a history of thyroid disease.  The frequency of such findings was with 33.0% in 46-65 years old persons three times higher then in persons aged 18-30 years (9.6%).  In the diagnostic workup thyroid cancer was detected in 15 patients operated on up to now (6 women and 9 men; papillary cancers in 12 cases, follicular cancers in 3 cases)  The smallest tumor had a diameter of 1.3 cm, the mean diameter was 2.3 +/- 91 cm.  In 3 patients the tumor had invaded the tissue  beyond the thyroid capsule, in 4 cases multicentric growth was detected.  Lymph node metastases were found in 7/15 cases and distant metastases in 2/15 cases. These result reveal, that thyroid cancer detected by chance may be relatively aggressive.  In daily routine, sonographically detectable lesions with poor echogenicity, irregular margins or internal calcifications with a diameter of more than 1 cm should be clarified by fine needle aspiration biopsy.
authors.affiliation: Klinik und Poliklinik für Nuklearmedizin, Universität Würzburg. Reiners_C@klinik.uni-wuerzburg.de
authors.forename: C
authors.initials: C
authors.lastname: Reiners
authors.forename: P M
authors.initials: PM
authors.lastname: Schumm-Draeger
authors.forename: M
authors.initials: M
authors.lastname: Geling
authors.forename: C
authors.initials: C
authors.lastname: Mastbaum
authors.forename: J
authors.initials: J
authors.lastname: Schönberger
authors.forename: A
authors.initials: A
authors.lastname: Laue-Savic
authors.forename: K
authors.initials: K
authors.lastname: Hackethal
authors.forename: R
authors.initials: R
authors.lastname: Hampel
authors.forename: U
authors.initials: U
authors.lastname: Heinken
authors.forename: W
authors.initials: W
authors.lastname: Kullak
authors.forename: R
authors.initials: R
authors.lastname: Linke
authors.forename: W
authors.initials: W
authors.lastname: Uhde
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001707:Biopsy, Needle; D003430:Cross-Sectional Studies; D005260:Female; D006043:Goiter, Endemic / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology; D006044:Goiter, Nodular / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008403:Mass Screening / Q000706:statistics & numerical data*; D008875:Middle Aged; D009367:Neoplasm Staging; D009786:Occupational Health Services / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D012737:Sex Factors; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology; D016606:Thyroid Nodule / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D014463:Ultrasonography