title: Oral subchronic toxicity of aqueous crude extract of Plantago australis leaves.
abstract: The toxic effects of chronic oral administration (60 days) of aqueous crude extract (AE) of Plantago australis Lam. (Plantaginaceae) in rats at doses of 850 and 1700 mg/kg on biochemical (ALT, AST, creatinine, urea, glucose, alkaline phosphatase, total proteins and albumin), hematological (complete hemogram), and histopathological (heart, lung, liver, kidney, esophagus, stomach and gut) parameters were studied. All biochemical and hematological parameters were found to be in the normal range, but ALT in animals that received AE of 850 mg/kg was higher. Histopathological analysis of organs, especially the liver did not present alterations.
authors.affiliation: Department of Physiology, Federal University of Santa Maria, RS 97105-900, Santa Maria, Brazil.
authors.forename: N M S
authors.initials: NM
authors.lastname: Palmeiro
authors.forename: C E
authors.initials: CE
authors.lastname: Almeida
authors.forename: P C
authors.initials: PC
authors.lastname: Ghedini
authors.forename: L S
authors.initials: LS
authors.lastname: Goulart
authors.forename: M C F
authors.initials: MC
authors.lastname: Pereira
authors.forename: S
authors.initials: S
authors.lastname: Huber
authors.forename: J E P
authors.initials: JE
authors.lastname: da Silva
authors.forename: S
authors.initials: S
authors.lastname: Lopes
mesh_terms: D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects; D000818:Animals; D001769:Blood / Q000187:drug effects; D001938:Brazil; D045424:Complex Mixtures / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry / Q000633:toxicity*; D010943:Plantago / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D045424:Complex Mixtures; D010936:Plant Extracts; D000410:Alanine Transaminase