[Use of pentaglobin in the treatment of sepsis in the patient undergoing intraperitoneal hyperthermic chemotherapy].
In patients subjected to cytoreduction and hyperthermic antiblastic peritoneal perfusion (HAPP), their immunocompromized conditions claim a very aggressive therapeutic approach in case of periotonitis and sepsis. Therefore, we use an adjuvant therapy of severe bacterial infections additional to antibiotic therapy by using Pentaglobin. It contains human plasma proteins, of which immunoglobulin at least 95%, with high rate of IgG, IgM and IgA, infused intravenously at 12 mL/h for 3 days continuously. From November 2000 to March 2003, we combined this approach for the treatment of peritonitis/sepsis in 11 patients. In 10 patients we obtained a complete control of the infective status in 8 days, while 1 patient died for MOFF. So, even with the exiguity of our casuistry, we obtained a better and more rapid clinical control of the patients respect to the previous period when the Pentaglobin was not used.
Vaira
M
M
Centro di Chirurgia Oncologica Avanzata, Torino.
Scuderi
S
S
Costamagna
D
D
Barone
R
R
De Simone
M
M
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D006979:Hyperthermia, Induced; D016867:Immunocompromised Host; D007070:Immunoglobulin A / Q000627:therapeutic use*; D007075:Immunoglobulin M / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D007263:Infusions, Parenteral; D007710:Klebsiella Infections / Q000188:drug therapy / Q000209:etiology; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000209:etiology; D018805:Sepsis / Q000188:drug therapy* / Q000209:etiology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007070:Immunoglobulin A; D007075:Immunoglobulin M; C060166:pentaglobulin