[Areas of brain involved in immunoregulation].
OBJECTIVE
To study the location of brain areas involved in immunoregulation.


METHODS
Immunohistochemistry and immunofluorescence were used to detect the different distribution of cytokines immunopositive cells in the brain of rats immunized via both intraperitoneal and subcutaneous injections.


RESULTS
The cytokines immunopositive cells were distributed in the supraoptic (SO) and paraventricular (PV) nuclei of the hypothalamus, the anterior hypothalamic (AH) nucleus, arcuate and median eminence, the lateral hypothalamic nucleus (LH) and the amygdaloid nuclear complex while only the appearance of the cytokines immunopositive cells in LH and amygdaloid nuclear complex in hypothalamus was related with immunization status of the animals. Double-labelling results showed that the cytokines immunopositive cells were neurons.


CONCLUSIONS
We have observed that neurons of the LH and amygdaloid nuclear complex in hypothalamus as a main source of the neuroimmunoregulation played a key role in neuroimmunoregulation and they participated in the neuroimmunoregulation at an early stage of the immune response.
Gao
Y
Y
Department of Immunology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China. gaoyang_1956@hotmail.com
Huang
Y
Y
Lin
J
J
Wang
D
D
Lin
R
R
D000679:Amygdala / Q000276:immunology*; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000276:immunology*; D015200:Fluoroimmunoassay; D007026:Hypothalamic Area, Lateral / Q000276:immunology*; D007150:Immunohistochemistry; D007378:Interleukins / Q000378:metabolism; D008297:Male; D015213:Neuroimmunomodulation / Q000502:physiology*; D051381:Rats; D011917:Rats, Inbred Lew; D016212:Transforming Growth Factor beta / Q000378:metabolism
D007378:Interleukins; D016212:Transforming Growth Factor beta