Detection of human papillomavirus DNA on the external genitalia of healthy men and male patients with urethritis.
BACKGROUND
Only a few studies have been done involving detection of human papillomavirus (HPV) DNA on the external genitalia of men without genital warts, although many have been done for women. We conducted HPV DNA detection among healthy male volunteers and men with urethritis, both having no visible lesions on their external genitalia.


OBJECTIVE
The goal of the study was to determine the detection rate of HPV DNA in volunteers and patients with urethritis and to determine risk factor(s) for positive DNA.


METHODS
This was a prospective clinical study.


RESULTS
HPV DNA was found in 1.3% of 75 volunteers and in 18.5% of 130 patients with urethritis. DNA of a high-intermediate oncogenic risk was more predominant than the low-risk type. Among various risk factors, only a history of STD was a significant factor for the positive detection of HPV DNA in multiple regression analysis.


CONCLUSIONS
HPV DNA was found in patients with urethritis more frequently than in volunteers, probably because the former had higher sexual activity.
Takahashi
Satoshi
S
Department of Urology, Sapporo Medical University School of Medicine, Japan.
Shimizu
Toshiaki
T
Takeyama
Kou
K
Kunishima
Yasuharu
Y
Hotta
Hiroshi
H
Koroku
Mikio
M
Tanda
Hitoshi
H
Saka
Taketoshi
T
Nishimura
Masahiro
M
Iwasawa
Akihiko
A
Furuya
Ryoji
R
Hirose
Takaoki
T
Kobayashi
Intetsu
I
Kumamoto
Yoshiaki
Y
Tsukamoto
Taiji
T
D000293:Adolescent; D000328:Adult; D004279:DNA, Viral / Q000032:analysis*; D005837:Genitalia, Male / Q000821:virology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D012725:Sexual Behavior; D014526:Urethritis / Q000453:epidemiology / Q000821:virology*
D004279:DNA, Viral