title: Antisaccade performance is abnormal in schizophrenia patients but not in their biological relatives.
abstract: Numerous studies have replicated the finding that schizophrenia patients make an increased number of errors on an antisaccade task. Some studies have reported that relatives of schizophrenia patients also make an increased number of antisaccade errors, a finding that has been interpreted to support the usefulness of compromised antisaccade performance as an index of genetic liability for schizophrenia. We examined performance on an antisaccade task in schizophrenia patients, nonpsychiatric controls, first-degree relatives of schizophrenia patients and first-degree relatives of nonpsychiatric controls. Schizophrenia patients made significantly more errors than did nonpsychiatric controls, but relatives of schizophrenia patients did not differ from relatives of controls or from all controls. Increased antisaccade errors on the standard version of the antisaccade task are associated with schizophrenia, but do not seem to be a co-familial trait for schizophrenia.
authors.affiliation: Psychology Research Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.
authors.forename: Joanna
authors.initials: J
authors.lastname: Brownstein
authors.forename: Olga
authors.initials: O
authors.lastname: Krastoshevsky
authors.forename: Courtney
authors.initials: C
authors.lastname: McCollum
authors.forename: Sapna
authors.initials: S
authors.lastname: Kundamal
authors.forename: Steven
authors.initials: S
authors.lastname: Matthysse
authors.forename: Philip S
authors.initials: PS
authors.lastname: Holzman
authors.forename: Nancy R
authors.initials: NR
authors.lastname: Mendell
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Levy
mesh_terms: D000328:Adult; D001767:Blinking / Q000502:physiology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005403:Fixation, Ocular; D006801:Humans; D008297:Male; D008875:Middle Aged; D012438:Saccades / Q000502:physiology*; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology*