Design and synthesis of paromomycin-related heterocycle-substituted aminoglycoside mimetics based on a mass spectrometry RNA-binding assay.
Ding
Yili
Y
Ribapharm, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA. yding@icnpharm.com
Hofstadler
Steven A
SA
Swayze
Eric E
EE
Risen
Lisa
L
Griffey
Richard H
RH
D000617:Aminoglycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D001667:Binding, Competitive; D002240:Carbohydrate Sequence; D015195:Drug Design; D008024:Ligands; D008956:Models, Chemical; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010303:Paromomycin / Q000737:chemistry*; D012336:RNA, Ribosomal, 16S / Q000737:chemistry* / Q000378:metabolism; D012337:RNA, Ribosomal, 18S / Q000737:chemistry* / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D000617:Aminoglycosides; D008024:Ligands; D012336:RNA, Ribosomal, 16S; D012337:RNA, Ribosomal, 18S; D010303:Paromomycin