title: Multiple spindle cell lipomas of the tongue: report of a case.
abstract: Spindle cell lipoma (SCL) is a relatively uncommon benign lipomatous tumor characterized by a mixture of mature adipocytes and bland spindle cells on a fibromyxoid background. These lipomas usually arise as solitary nodules in the subcutaneous tissue of the posterior neck, shoulder and back in adult men. Multiple SCLs account for 0.5% to 3% of all SCLs. In the literature, there have been 15 cases of intraoral SCL, including 6 cases of SCL in the tongue. We report a case of multiple SCLs on the bilateral margins of the tongue of a 75-year-old Japanese man. The tumors were removed surgically, and they exhibited the classic histopathological features of SCL, being well-circumscribed masses composed of a mixture of adipocytes and fibroblast-like spindle cells within a fibromyxoid stroma. Immunohistochemical analysis revealed that the spindle cells were strongly positive for CD 34 and bcl-2. To our knowledge, this is the first report of a case of multiple SCLs of the tongue.
authors.affiliation: Department of Pathology, Oita Medical University, Oita, Japan. naokaku@oita-med.ac.jp
authors.forename: Naomi
authors.initials: N
authors.lastname: Kaku
authors.forename: Kenji
authors.initials: K
authors.lastname: Kashima
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Daa
authors.forename: Iwao
authors.initials: I
authors.lastname: Nakayama
authors.forename: Hideomi
authors.initials: H
authors.lastname: Kerakawauchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yokoyama
mesh_terms: D017667:Adipocytes / Q000473:pathology; D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008067:Lipoma / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D014062:Tongue Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D018952:Antigens, CD34; D019253:Proto-Oncogene Proteins c-bcl-2