Xenotransplantation of stem/progenitor cells from human fetal brain to adult rats with spinal trauma.
In vitro grown neural stem cells from human fetal brain were transplanted to adult rats with spinal trauma. The spinal cord was examined morphologically using histological and immunohistochemical methods on days 5, 15, 30, and 110. Human neural stem/progenitor cells were viable, migrated, and differentiated into neurons and glia in the traumatized spinal cord in adult rats.
Stepanov
G A
GA
Central Institute of Traumatology and Orthopedics, Moscow.
Karpenko
D O
DO
Aleksandrova
M A
MA
Podgornyi
O V
OV
Poltavtseva
R A
RA
Pevishchin
A V
AV
Marey
M V
MV
Sukhikh
G T
GT
D000818:Animals; D006690:Bisbenzimidazole / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement; D002470:Cell Survival; D005260:Female; D016332:Fetal Tissue Transplantation; D005456:Fluorescent Dyes / Q000378:metabolism; D006801:Humans; D007381:Intermediate Filament Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D064231:Nestin; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000166:cytology / Q000473:pathology; D013119:Spinal Cord Injuries / Q000473:pathology / Q000628:therapy*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology*; D014183:Transplantation, Heterologous
D005456:Fluorescent Dyes; D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; C577486:Nes protein, rat; D064231:Nestin; D006690:Bisbenzimidazole