Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus.
Fruiting bodies of Phellinus linteus were extracted with 70% ethanol at room temperature. The Phellinus linteus extract (PL) showed strong anti-angiogenic activity, which was detected using the chick embryo chorioallantoic membrane (CAM) assay. The in vitro antioxidant activities of PL were evaluated using two different bioassays. PL was comparable to Vitamin C in scavenging the stable free radical 1,1-diphenyl-2-picrylhyrazyl (DPPH). It also inhibited lipid peroxidation (LPO) in a concentration-dependent manner. These results suggest that antioxidant and anti-angiogenic activities of Phellinus linteus would be partly responsible for its anti-tumor effect.
Song
Yun Seon
YS
Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, 130-650 Seoul, South Korea.
Kim
Sun-Hyoung
SH
Sa
Jae-Hoon
JH
Jin
Changbae
C
Lim
Chang-Jin
CJ
Park
Eun-Hee
EH
D000363:Agaricales / Q000737:chemistry* / Q000378:metabolism; D020533:Angiogenesis Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002642:Chick Embryo; D016166:Free Radical Scavengers / Q000378:metabolism / Q000494:pharmacology; D006834:Hydrazines / Q000378:metabolism; D007723:Korea; D015227:Lipid Peroxidation / Q000187:drug effects; D010851:Picrates; D051381:Rats; D017207:Rats, Sprague-Dawley; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000494:pharmacology*
D020533:Angiogenesis Inhibitors; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006834:Hydrazines; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl; D014969:Xanthine Oxidase; D001205:Ascorbic Acid