Chondroprotective agents: glucosamine and chondroitin.
The near universal finding of the safety of glucosamine and chondroitin combined with some compelling evidence of their efficacy should spur further research into their mechanism of action, optimal dosing, long-term effects on disease modification, and clinical applicability. When recommending a supplement to patients, the clinician should take into account the purity of the ingredients, reputation of the manufacturer, and the molecular weight of chondroitin supplied.
Hungerford
Marc W
MW
Johns Hopkins University, Suite G-1 Professional Office Building, 5601 Loch Raven Boulevard, Baltimore, MD 21239, USA. mhunger@Jhmi.edu
Valaik
Daniel
D
D001682:Biological Availability; D002356:Cartilage / Q000033:anatomy & histology / Q000502:physiology / Q000503:physiopathology; D002807:Chondroitin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005944:Glucosamine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy* / Q000378:metabolism
D002807:Chondroitin; D005944:Glucosamine