title: Functional regulation of biomolecule using DNA-conjugation.
abstract: 3'-methacryloyl-oligodeoxynucleotide having antisense sequence against messenger RNA of green fluorescent protein and N-isopropylacrylamide were co-polymerized. The conjugate can reversibly change its conformation at around a transition temperature, similarly to N-isopropylacrylamide homopolymer. We achieved artificially regulation of gene expression depending on temperature using the conjugate.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 6-10-1, Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Anada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kano
authors.forename: Wataru
authors.initials: W
authors.lastname: Kaku
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Katayama
authors.forename: Mizuo
authors.initials: M
authors.lastname: Maeda
authors.forename: Masaharu
authors.initials: M
authors.lastname: Murata
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D016376:Oligonucleotides, Antisense / Q000737:chemistry
chemical_list: D016376:Oligonucleotides, Antisense; D004247:DNA