Effects of growth hormone on lipid metabolism in humans.
The most immediate effect of growth hormone (GH) administration in humans is a significant increase in free fatty acids after 1-2 h, reflecting stimulation of lipolysis and ketogenesis. This stimulation represents an important physiological adaptation to stress and fasting. When the capacity of GH to increase lipolysis is blocked, the protein-retaining and insulin-antagonistic effects of GH on glucose metabolism are either abolished or weakened dramatically, compatible with a key role for lipolysis in orchestrating the metabolic actions of GH.
Møller
Niels
N
Medical Department M (Endocrinology and Diabetes), Institute of Experimental Research, University of Aarhus, Aarhus C, 8000, Denmark. nielsem@dadlnet.dk
Gjedsted
Jakob
J
Gormsen
Lars
L
Fuglsang
Jens
J
Djurhuus
Christian
C
D001823:Body Composition; D050260:Carbohydrate Metabolism; D013006:Growth Hormone / Q000502:physiology*; D006801:Humans; D050356:Lipid Metabolism; D011506:Proteins / Q000378:metabolism
D011506:Proteins; D013006:Growth Hormone