Effect of L-fucose and fucose-rich oligo- and polysaccharides (FROP-s) on skin aging: penetration, skin tissue production and fibrillogenesis.
Skin thickness is decreasing with age. This loss concerns both dermis and epidermis, cells and extracellular matrix. We could show here that percutaneous application of an L-fucose-containing preparation produced an increase of skin thickness and a densification of collagen bundles. We also could show that 3H-L-fucose penetrates in the dermis, a prerequisite for the above mentioned favorable pharmacological activities. These results, together with the previous favorable activities on the downregulation of matrix-degrading enzymes, free radical scavenging and increased cell proliferation confirm the favorable action of fucose and fucose-rich polysaccharides (FROP-s) on the skin by slowing down its aging.
Fodil-Bourahla
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Laboratoire universitaire de recherche en ophtalmologie, faculté de médecine Broussais-Hôtel Dieu, Universite Pierre-et-Marie-Curie (Paris 6), 1, place du Parvis Notre Dame, 75181 Paris cedex 4, France.
Bizbiz
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Schoevaert
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Robert
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Robert
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D000287:Administration, Topical; D000818:Animals; D005260:Female; D024022:Fibrillar Collagens / Q000187:drug effects*; D005643:Fucose / Q000493:pharmacokinetics / Q000494:pharmacology*; D009844:Oligosaccharides / Q000493:pharmacokinetics / Q000494:pharmacology; D011134:Polysaccharides / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012869:Skin Absorption; D015595:Skin Aging / Q000187:drug effects*
D024022:Fibrillar Collagens; D009844:Oligosaccharides; D011134:Polysaccharides; D005643:Fucose