[Prevention of adverse reactions of antituberculous drugs in pulmonary tuberculosis in patients with different genetic background].
A hundred and sixty-seven patients with pulmonary tuberculosis were examined to study the genetic predisposition to adverse reactions (AR) from chemical drugs. The phenotype of haptoglobin carriage, the type of, the activity of the enzyme glucose-6-phosphate dehydrogenase inactivation were used as a genetic marker. If with a poor combination of the above parameters AR developed in 100%; with their relative combination, it occurred in 78%. With other types of their combinations, AR took place only in 38%. A new method for preventing AR in pulmonary tuberculosis is proposed by using non-traditional methods, such as phytotherapy alone and in combination with ultraviolet autoblood irradiation. The use of this method is shown to reduce the incidence of AR, to attenuate their severity and clinical manifestations particularly in patients with a relatively poor genetic background.
Tashpulatova
F K
FK
D000995:Antitubercular Agents / Q000009:adverse effects*; D003131:Combined Modality Therapy; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008517:Phytotherapy / Q000379:methods*; D014397:Tuberculosis, Pulmonary / Q000235:genetics* / Q000628:therapy*
D000995:Antitubercular Agents; D005819:Genetic Markers