title: Neonatal transection of the corpus callosum affects paw preference lateralization of adult Swiss mice.
abstract: In the present work, the hypothesis that the ontogenetic development of the corpus callosum (CC) affects the establishment of behavioral lateralization was tested by studying paw preference performance in adult Swiss mice that were subjected to mid-sagittal transection of the CC on the first postnatal day. Magnitude and direction of laterality were evaluated independently. No significant differences between groups were found for the magnitude of paw preference. On the other hand, the transected group presented a significant populational bias favoring the left paw that was not present in the control groups. These results lend support to the hypothesis that the development of the CC plays a role in the establishment of the normal pattern of behavioral lateralization.
authors.affiliation: Laboratório de Neurofisiologia, Departamento de Ciências Fisiológicas, IBRAG, Universidade do Estado do Rio de Janeiro, Boulevard 28 de Setembro, 87, fundos, 5 andar, Vila Isabel, Rio de Janeiro, RJ 20.551-030, Brazil. amanhaes@uerj.br
authors.forename: Alex C
authors.initials: AC
authors.lastname: Manhães
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Krahe
authors.forename: Egas
authors.initials: E
authors.lastname: Caparelli-Dáquer
authors.forename: Anderson
authors.initials: A
authors.lastname: Ribeiro-Carvalho
authors.forename: Sergio L
authors.initials: SL
authors.lastname: Schmidt
authors.forename: Cláudio C
authors.initials: CC
authors.lastname: Filgueiras
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation / Q000502:physiology; D003337:Corpus Callosum / Q000254:growth & development* / Q000293:injuries / Q000502:physiology*; D003714:Denervation; D005552:Forelimb / Q000294:innervation / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology*; D020439:Growth Cones / Q000502:physiology; D008297:Male; D051379:Mice; D009044:Motor Cortex / Q000254:growth & development* / Q000502:physiology*; D009068:Movement / Q000502:physiology