Pyrimidifen intoxication.
We present a case of lethal ingestion of pyrimidifen, a new insecticide with an unclear mode of action. The primary manifestations were coma and circulatory shock, leading to irreversible multiorgan failure. Pyrimidifen was detected in the patient's blood, urine, brain tissue, and gastric content samples. Minimal structural homology exists between pyrimidifen and organochlorines. Currently, no antidote is available, and therapy is primarily supportive.
Eisinger
Miruna
M
Division of Internal Medicine, Soroka University Medical Center, and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Almog
Yaniv
Y
D000328:Adult; D003128:Coma / Q000139:chemically induced* / Q000628:therapy; D004638:Emergency Treatment / Q000379:methods; D017809:Fatal Outcome; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry / Q000506:poisoning*; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D009102:Multiple Organ Failure / Q000139:chemically induced* / Q000628:therapy; D011743:Pyrimidines / Q000737:chemistry / Q000506:poisoning*; D012769:Shock / Q000139:chemically induced* / Q000628:therapy
D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D011743:Pyrimidines; C476509:pyrimidifen