title: [Investigation of a fetal heart-rate pattern that shows a reduced oscillation amplitude].
abstract: A fetal heart-rate pattern that has a reduced oscillation amplitude may indicate a physiological fetal dormant period but could also be an indication of fetal hypoxemia. In some rare cases such a fetal heart rate-pattern can be an indicator of cerebral or cardial fetal malformation or of an intoxication caused by sedative drugs. Our patient is a 32-year-old Para III in the phase of 29 weeks and 3 days gestation. Upon admission to the clinic, the fetal heart-rate pattern showed a reduced oscillation amplitude, and there were no signs of fetal movement. The ultrasound examination gave us no reason to suspect fetal malformation, and the results of the Doppler ultrasonography were also normal. However, although the patient had denied taking any medication at all, the results of an toxicological blood test confirmed our suspicion of benzodiazepine intoxication. Throughout the night the fetal heart-rate pattern was continuously measured, and in the early hours of the morning, after breaking down of the oxazepam medication, a normalization of the fetal heart-rate pattern was observed. This case report definitively demonstrates that Doppler ultrasonography is a valuable method for assessing any uncertainty regarding a fetal heart-rate pattern.
authors.affiliation: Universitäts-Frauenklinik Mannheim, Fakultät für klinische Medizin der Ruprecht-Karls-Universität Heidelberg, Mannheim.
authors.forename: C
authors.initials: C
authors.lastname: Stähle
authors.forename: F
authors.initials: F
authors.lastname: Melchert
authors.forename: M
authors.initials: M
authors.lastname: Weigel
mesh_terms: D000328:Adult; D015148:Cardiotocography / Q000187:drug effects; D003937:Diagnosis, Differential; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis; D005311:Fetal Hypoxia / Q000175:diagnosis*; D006340:Heart Rate, Fetal / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000175:diagnosis*; D009991:Oscillometry; D010076:Oxazepam / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D015145:Tocolysis; D016216:Ultrasonography, Prenatal
chemical_list: D010076:Oxazepam