title: [B cell activated co-receptor].
abstract: B cell activated co-receptor plays important roles in linkage of innate and acquired humoral immune responses. CD21 molecule in the co-receptor complex is a receptor for C3dg and CD19 molecule enhances BCR signal transduction. CD21 also expresses on the surface of follicular dendritic cells, which mediates the long-term maintenance of antigens and is indispensable for maintaining the memory of B cells. B cell activated co-receptor also has an effect on the negative selection of B cells reactive to autoantigens.
authors.affiliation: Department of Clinical Medicine, PUMC, Beijing 100730, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Ruan
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Zhu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D018941:Antigens, CD19 / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D017464:Receptors, Complement 3d / Q000276:immunology; D011971:Receptors, Immunologic
chemical_list: D018941:Antigens, CD19; D001324:Autoantigens; D017464:Receptors, Complement 3d; D011971:Receptors, Immunologic