Interleukin-6 and oligoclonal IgG synthesis in children with acute disseminated encephalomyelitis.
Interleukin-6 (IL-6) has a number of roles including recruitment of T lymphocytes and differentiation of B lymphocytes into IgG-secreting plasma cells. Furthermore, IL-6 is a neuropoietic cytokine with effects on neuronal differentiation, function and survival. We studied IL-6 concentrations in children with acute disseminated encephalomyelitis (ADEM; n = 14), and compared the values with those obtained from control patients with other inflammatory (OIND; n = 13) and non-inflammatory (NIND; n = 10) neurological disorders. Patients with ADEM had a significantly increased CSF IL-6 concentration compared with both OIND and NIND groups ( P < 0.01). Serum IL-6 was also increased in the ADEM group compared with the OIND group ( P < 0.05). CSF: serum IL-6 ratios were significantly increased in the ADEM group compared with the NIND group ( P < 0.05), suggesting an intrathecal production of IL-6 rather than its passive transfer across the blood-brain barrier alone. In ADEM, there was a significant correlation between an increased CSF IL-6 and an identical pattern of oligoclonal IgG synthesis in both serum and CSF ( P < 0.05). These results would suggest a role for IL-6 in the pathology of ADEM, and a possible direct link between an increased IL-6 and a proliferation of B lymphocytes with consequent IgG production.
Dale
R C
RC
Neurosciences Unit, Institute of Child health and Great Ormond Street Hospital NHS Trust, London, UK. R.Dale@ion.ucl.ac.uk
Morovat
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A
D000293:Adolescent; D001921:Brain / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003711:Demyelinating Diseases / Q000473:pathology; D004673:Encephalomyelitis, Acute Disseminated / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D008279:Magnetic Resonance Imaging; D008297:Male; D043025:Oligoclonal Bands
D007136:Immunoglobulins; D015850:Interleukin-6; D043025:Oligoclonal Bands