title: Progression of renal disease measured by the reciprocal of serum creatinine.
abstract: BACKGROUND
  This study aims to quantify the decrease in the reciprocal of serum creatinine during the two years prior to the start of dialysis and to identify the factors associated with the progression of renal disease.
  
  
  METHODS
  The study included 76 patients who were monitored for an average of 26.27 months. During the study 52 patients began dialysis treatments. The clinical and analytical variables were analyzed using the t-student test, ANOVA or the Kruskall-Wallis test. A multiple regression analysis was carried out with the decrease in the reciprocal of serum creatinine as the dependent variable.
  
  
  RESULTS
  There was a decrease between the mean value during the two years prior to dialysis, the mean value during the previous year and the value at the start of dialysis treatments of 0.29, 0.21 and 0.17 respectively. The nephropathy having the sharpest drop in the reciprocal of serum creatinine, expressed as a percentage of the initial value, was found to be nephroangiosclerosis (46.29%). A greater decline in the reciprocal of serum creatinine was exhibited by low albumin values and adjusted by means of different variables with LDL levels (p = 0.141). For different levels of haemoglobin, proteinuria and cholesterol, the drop in the reciprocal of serum creatinine was greater in patients having a diastolic blood pressure reading of 90 or greater.
  
  
  CONCLUSIONS
  The decrease in the reciprocal of serum creatinine was associated with different variables in patients who required dialysis.
authors.affiliation: Unidad de Epidemiología Clinica y Bioestadistica, Complexo Hospitalario Juan, Canalejo, A Coruña, Spain. spita@canalejo.org
authors.forename: Salvador
authors.initials: S
authors.lastname: Pita-Fernández
authors.forename: Dolores
authors.initials: D
authors.lastname: Lorenzo-Aguiar
authors.forename: Sonia
authors.initials: S
authors.lastname: Pértega-Díaz
authors.forename: Francisco
authors.initials: F
authors.lastname: Valdés-Cañedo
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D003404:Creatinine / Q000097:blood*; D003971:Diastole / Q000502:physiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012709:Serum Albumin / Q000378:metabolism; D012737:Sex Factors; D013223:Statistics as Topic; D013997:Time Factors; D014508:Urea / Q000097:blood
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; D012709:Serum Albumin; D014508:Urea; D003404:Creatinine