title: Positive end-expiratory pressure modulates perfluorochemical evaporation from the lungs.
abstract: To study the effects of positive end-expiratory pressure (PEEP) level on perfluorochemical (PFC) elimination profiles (E(L)), 6 ml/kg of perflubron were instilled into healthy anesthetized rabbits. The ventilation strategy was to maintain constant minute ventilation (300 ml/kg/min) and mean airway pressure (7-8 cm H(2)O) while randomly changing the PEEP levels from 5 to 0, 1, 3, and 10 cm H(2)O, each for a period of 15 min. The PFC content in the expired gas was measured and the E(L) was calculated. There was a significant reduction in the E(L) when decreasing the PEEP levels from 5 to 0 cm H(2)O, but no differences were seen when the PEEP was increased from 5 to 10 cm H(2)O. The results indicate that PEEP levels influence PFC elimination profiles; therefore, the measurement of the E(L) and PEEP levels should be considered when optimizing supplemental PFCs during partial liquid ventilation.
authors.affiliation: Department of Pediatrics, Padua University, Padua, Italy. trevo@child.pedi.unipd.it
authors.forename: D
authors.initials: D
authors.lastname: Trevisanuto
authors.forename: M J
authors.initials: MJ
authors.lastname: Jeng
authors.forename: C M
authors.initials: CM
authors.lastname: Weis
authors.forename: W W
authors.initials: WW
authors.lastname: Fox
authors.forename: M R
authors.initials: MR
authors.lastname: Wolfson
authors.forename: T H
authors.initials: TH
authors.lastname: Shaffer
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000008:administration & dosage; D004655:Emulsions; D005466:Fluorocarbons / Q000008:administration & dosage* / Q000032:analysis; D006339:Heart Rate; D006842:Hydrocarbons, Brominated; D021061:Liquid Ventilation; D010100:Oxygen / Q000032:analysis / Q000097:blood; D011175:Positive-Pressure Respiration; D011817:Rabbits; D014867:Water / Q000032:analysis
chemical_list: D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D014867:Water; D002245:Carbon Dioxide; C003072:perflubron; D010100:Oxygen