Effects of normal aging and Alzheimer's disease on emotional memory.
Recall is typically better for emotional than for neutral stimuli. This enhancement is believed to rely on limbic regions. Memory is also better for neutral stimuli embedded in an emotional context. The neural substrate supporting this effect has not been thoroughly investigated but may include frontal lobe, as well as limbic circuits. Alzheimer's disease (AD) results in atrophy of limbic structures, whereas normal aging relatively spares limbic regions but affects prefrontal areas. The authors hypothesized that AD would reduce all enhancement effects, whereas aging would disproportionately affect enhancement based on emotional context. The results confirmed the authors' hypotheses: Young and older adults, but not AD patients, showed better memory for emotional versus neutral pictures and words. Older adults and AD patients showed no benefit from emotional context, whereas young adults remembered more items embedded in an emotional versus neutral context.
Kensinger
Elizabeth A
EA
Department of Brain and Cognitive Sciences, Clinical Research Center, Massachusetts Institute of Technology, Cambridge 02139, USA. ekensing@mit.edu
Brierley
Barbara
B
Medford
Nick
N
Growdon
John H
JH
Corkin
Suzanne
S
D000328:Adult; D000368:Aged; D000375:Aging / Q000523:psychology*; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology*; D001245:Association Learning; D001288:Attention; D004644:Emotions; D005260:Female; D005364:Field Dependence-Independence; D006801:Humans; D007092:Imagination; D008297:Male; D011939:Mental Recall; D010364:Pattern Recognition, Visual; D011597:Psychomotor Performance; D012016:Reference Values; D012153:Retention, Psychology; D012660:Semantics; D012691:Serial Learning; D014706:Verbal Learning