Condensation reaction of hexanucleotides containing guanine and cytosine with water soluble carbodiimide.
The condensation reactions of hexanucleotides involving guanine and cytosine in the presence of water-soluble carbodiimide (WSC) have been investigated as a model reaction of the prebiotic formation of RNA under primitive earth. The reactions formed cyclic hexanucleotides and dimers in which the product yields were dependent on the sequence.
Kawamura
K
K
Department of Applied Chemistry, College of Engineering, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
Okamoto
F
F
D001483:Base Sequence; D002234:Carbodiimides; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D003596:Cytosine / Q000737:chemistry; D006147:Guanine / Q000737:chemistry; D007202:Indicators and Reagents; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D012995:Solubility; D014867:Water
D002234:Carbodiimides; D007202:Indicators and Reagents; D009841:Oligonucleotides; D014867:Water; C074139:1-ethyl-3-(3-dimethylaminoethyl)carbodiimide; D006147:Guanine; D003596:Cytosine