Comparison of clinical benefits of clopidogrel therapy in patients with acute coronary syndromes taking atorvastatin versus other statin therapies.
In clinical practice, we found no significant difference between atorvastatin therapy or other statin therapies in the clinical outcomes of patients with acute coronary syndromes receiving clopidogrel therapy. In patients receiving atorvastatin therapy, clopidogrel therapy was associated with a significant decrease in mortality and stroke during univariate analysis and a moderate trend of reduced mortality and stroke without statistical significance in the multivariate analysis.
Wienbergen
Harm
H
Herzzentrum Ludwigshafen, Ludwigshafen, Germany. HarmWnbrgn@aol.com
Gitt
Anselm Kai
AK
Schiele
Rudolf
R
Juenger
Claus
C
Heer
Tobias
T
Meisenzahl
Christina
C
Limbourg
Peter
P
Bossaller
Claus
C
Senges
Jochen
J
D000208:Acute Disease; D000368:Aged; D000069059:Atorvastatin; D000077144:Clopidogrel; D015897:Comorbidity; D003327:Coronary Disease / Q000188:drug therapy* / Q000401:mortality; D004347:Drug Interactions; D004363:Drug Utilization / Q000706:statistics & numerical data; D005260:Female; D005858:Germany / Q000453:epidemiology; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011758:Pyrroles / Q000627:therapeutic use*; D012042:Registries / Q000706:statistics & numerical data; D020521:Stroke / Q000453:epidemiology; D016019:Survival Analysis; D013577:Syndrome; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D016896:Treatment Outcome
D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin; D000077144:Clopidogrel; D013988:Ticlopidine