The role of dendritic cell subsets in immunity to viruses.
Dendritic cells orchestrate the adaptive immune response. As well as presenting MHC-restricted antigen for T-cell activation, they provide all the co-receptor signals required for full T-cell priming. As a consequence, they play a central role in the immune response to infections caused by many pathogenic agents, including viruses. In recent times, it has become apparent that dendritic cells represent a particularly heterogeneous population with individual subsets playing specialized roles in response to infection.
Carbone
Francis R
FR
Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia. fcarbone@unimelb.edu.au
Heath
William R
WR
D000818:Animals; D003713:Dendritic Cells / Q000145:classification / Q000276:immunology* / Q000821:virology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology