Modeling of a possible evolutional process from a ribozyme to a catalytic RNP.
A model process for molecular evolution from an RNA enzyme to a catalytic RNA-protein complex (RNP) is proposed. In the model, one RNA-RNA interaction in the enzyme is replaced by an RNA-protein interaction via an intermediary state where the original RNA-RNA and newly introduced RNA-protein interaction co-exist. To test the model, a catalytic RNP was designed and examined by employing the Tetrahymena ribozyme.
Ikawa
Yoshiya
Y
Graduate School of Biostudies, Kyoto University, Kyoto, 606-8502, Japan.
Tsuda
Kentaro
K
Matsumura
Shigeyoshi
S
Atsumi
Shota
S
Inoue
Tan
T
D000818:Animals; D002384:Catalysis; D019143:Evolution, Molecular; D016337:RNA, Catalytic / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D012261:Ribonucleoproteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D013768:Tetrahymena / Q000201:enzymology
D016337:RNA, Catalytic; D012261:Ribonucleoproteins