Breast tumor resembling the tall cell variant of papillary thyroid carcinoma: report of 5 cases.
Five cases of a hitherto undescribed breast tumor having histologic features similar to those of the tall cell variant papillary thyroid carcinoma are described. They were composed of columnar mitochondrion-rich to oxyphilic cells arranged in nests, papillae, and follicle-like structures. In addition, the neoplastic cells showed numerous nuclear grooves and, in two cases, nuclear pseudo-inclusions. None of the patients had previous concomitant or subsequent evidence of a thyroid tumor. Immunohistochemistry further excluded a metastasis from the thyroid in the four cases tested, as they were consistently thyroglobulin and thyroid transcription factor 1 negative.
Eusebi
V
V
Department of Oncologic Science, Section of Anatomic Pathology, University of Bologna, Italy. vicenzo.eusebi@ausl.bo.it
Damiani
S
S
Ellis
I O
IO
Azzopardi
J G
JG
Rosai
J
J
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D018265:Carcinoma, Papillary, Follicular / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D024862:Oxyphil Cells / Q000737:chemistry / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor