title: [Studies on the relationship between D6S1581, a high frequency allele imbalance locus, and genetic susceptibility to nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To investigate the relationship of nasopharyngeal carcinoma (NPC) with the high frequency allele imbalance locus D6S1581, and the NPC associated gene FBXO30 which is located near D6S1581.
  
  
  METHODS
  Genescan was used to genotype D6S1581 of 12 NPC pedigrees, 85 sporadic NPC patients and 181 normal volunteers. Then parametric/nonparametric linkage analysis and association analysis were performed.
  
  
  RESULTS
  D6S1581 was linked with NPC, a Lod score of 2.611436 (P=0.00245) was obtained, and a significant difference in allele frequency was observed between familial NPC and control (P<0.005).
  
  
  CONCLUSIONS
  These results suggest that D6S1581 is highly associated with NPC, and there may be one or more NPC associated genes near D6S1581, including FBXO30.
authors.affiliation: Cancer Research Institute, Xiangya Medical School, Changsha, Hunan, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
authors.forename: Zhao-yang
authors.initials: ZY
authors.lastname: Zeng
authors.forename: Shou-rong
authors.initials: SR
authors.lastname: Shen
authors.forename: Xiao-ling
authors.initials: XL
authors.lastname: Li
authors.forename: Wei-fang
authors.initials: WF
authors.lastname: Li
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Xiong
authors.forename: Cong
authors.initials: C
authors.lastname: Peng
authors.forename: Qiu-hong
authors.initials: QH
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.forename: Yi-xin
authors.initials: YX
authors.lastname: Yang
authors.forename: Hou-de
authors.initials: HD
authors.lastname: Zhou
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.forename: Gui-yuan
authors.initials: GY
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002681:China; D044783:F-Box Proteins / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D010375:Pedigree
chemical_list: D044783:F-Box Proteins