[Light- and temperature-induced degradation of fumagillin].
The antibiotic fumagillin with amebicidal and fungicidal effects isolated from Aspergillus fumigatus is the only presently known agent for the treatment of life threatening serious microsporidiosis occurring in patients with AIDS. Fumagillin and its degradation products were measured by HPLC at given time intervals after storage under defined conditions (temperature, relative humidity). Significant degradation took place even in samples stored in freezer; therefore fumagillin drug substance should be stored below -60 degrees C. Light also induced a degradation process in fumagillin, thus it is proposed to be stored and transported in brown glass.
Agner
Gabriella
G
Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt., Budapest, Tó u. 1-5.-1045.
Gyórbíró
Andrea
A
Valkó
István
I
Vasvári-Debreczy
Lelle
L
Szabó
Anna
A
Farkas
Gyula
G
Halász
Judit
J
Podányi
Benjámin
B
Brlik
János
J
Simon
Kálmán
K
Hermecz
Istvan
I
D000563:Amebicides / Q000737:chemistry / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000627:therapeutic use; D003510:Cyclohexanes; D004355:Drug Stability; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000528:radiation effects / Q000627:therapeutic use; D006801:Humans; D008027:Light; D012717:Sesquiterpenes; D013816:Thermodynamics
D000563:Amebicides; D000900:Anti-Bacterial Agents; D003510:Cyclohexanes; D005231:Fatty Acids, Unsaturated; D012717:Sesquiterpenes; C026211:fumagillin