title: [Optic disk neovascularization in fungal endophthalmitis].
abstract: A case of optic disk neovascularization is reported in a 30-year-old female heroin addict with suspected fungal endophthalmitis treated with an intravitreal injection of amphotericin B and fluconazole (200mg/day). Membrane healing was characterized by densification and contraction leading to tractional retinal detachment; excision by vitrectomy was required. Electron microscopy analysis of the membrane removed the tenth month revealed a poorly vascularized fibrous tissue infiltrated by chronic inflammatory cells. Visual improvement was poor owing to a postoperative macular disorder and a full-thickness retinal scar.
authors.affiliation: Service d'Ophtalmologie, Hôpital St Roch, 5, rue Pierre Dévoluy, 06006 Nice Cedex 01. betis@unice.fr
authors.forename: F
authors.initials: F
authors.lastname: Bétis
authors.forename: J-M
authors.initials: JM
authors.lastname: Leguay
authors.forename: C
authors.initials: C
authors.lastname: Zur
authors.forename: P
authors.initials: P
authors.lastname: Hofman
authors.forename: P
authors.initials: P
authors.lastname: Gastaud
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D009877:Endophthalmitis / Q000175:diagnosis*; D015821:Eye Infections, Fungal / Q000175:diagnosis*; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007267:Injections; D009389:Neovascularization, Pathologic / Q000209:etiology*; D009898:Optic Disk / Q000098:blood supply*; D012163:Retinal Detachment / Q000209:etiology / Q000601:surgery; D014821:Vitrectomy
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole