LPO and antioxidant defense in the stomach of albino rats injected with angiotensin II and enalapril maleate.
The effects of components of angiotensin II system on LPO and antioxidant defense in the stomach of adult albino rats were studied using biochemical and chemiluminescent methods. Five intraperitoneal injections of angiotensin II in a dose of 100 micro/kg activated LPO and inhibited antioxidant processes in the studied tissues. Oral therapy with enalapril maleate (inhibitor of angiotensin-converting enzyme) in a daily dose of 10 mg/kg for 2 weeks normalized stress-activated LPO processes in gastric tissue.
Pikalova
V M
VM
Central Research Laboratory, Department of Biochemistry, Far-Eastern State Medical University, Khabarovsk. nive@mail.ru
Postupaev
V V
VV
Timoshin
S S
SS
D000804:Angiotensin II / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D004656:Enalapril / Q000008:administration & dosage / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D051381:Rats; D013270:Stomach / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000975:Antioxidants; D008054:Lipid Peroxides; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D004656:Enalapril