Protective efficacy of an AIDS vaccine, a single DNA priming followed by a single booster with a recombinant replication-defective Sendai virus vector, in a macaque AIDS model.
We previously demonstrated the excellent protective efficacy of DNA priming followed by Gag-expressing Sendai virus (SeV) boosting (DNA prime/SeV-Gag boost vaccine) against a pathogenic simian-human immunodeficiency virus (SHIV89.6PD) infection in macaques. Here we show that we established a practical, safer AIDS vaccine protocol, a single DNA priming followed by a single booster with a recently developed replication-defective F deletion SeV-expressing Gag, and show its protective efficacy against SHIV89.6PD infections.
Takeda
Akiko
A
Department of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Igarashi
Hiroko
H
Nakamura
Hiromi
H
Kano
Munehide
M
Iida
Akihiro
A
Hirata
Takahiro
T
Hasegawa
Mamoru
M
Nagai
Yoshiyuki
Y
Matano
Tetsuro
T
D016915:AIDS Vaccines / Q000008:administration & dosage* / Q000235:genetics; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004279:DNA, Viral / Q000008:administration & dosage* / Q000235:genetics; D003673:Defective Viruses / Q000235:genetics; D004195:Disease Models, Animal; D015750:Genes, gag; D005822:Genetic Vectors; D006801:Humans; D007117:Immunization, Secondary; D008252:Macaca fascicularis; D008253:Macaca mulatta; D018449:SAIDS Vaccines / Q000008:administration & dosage / Q000235:genetics; D029082:Sendai virus / Q000235:genetics; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000517:prevention & control; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000235:genetics
D016915:AIDS Vaccines; D004279:DNA, Viral; D018449:SAIDS Vaccines; D019444:Vaccines, DNA