Enterostatin (VPDPR) and its peptide fragment DPR reduce serum cholesterol levels after oral administration in mice.
We found that enterostatin (VPDPR), an anorexigenic peptide for a high-fat diet, significantly reduces serum cholesterol levels after oral administration of 100 mg/kg for 3 days in mice fed a high cholesterol-cholic acid diet. DPR, a peptide fragment of VPDPR, also had hypocholesterolemic activity at a dose of 50 mg/kg. Food intake was not suppressed under these dietary conditions. Fecal excretion of cholesterol and bile acids was increased significantly by both VPDPR and DPR. Interestingly, DPR induced hypocholesterolemic effects just two hours after a single oral administration at a dose of 100 mg/kg.
Takenaka
Yasuyuki
Y
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Japan.
Nakamura
Futoshi
F
Yamamoto
Taichi
T
Yoshikawa
Masaaki
M
D000284:Administration, Oral; D000818:Animals; D002784:Cholesterol / Q000032:analysis / Q000097:blood*; D004041:Dietary Fats / Q000008:administration & dosage; D005243:Feces / Q000737:chemistry; D008099:Liver / Q000737:chemistry / Q000187:drug effects; D051379:Mice; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*
D004041:Dietary Fats; D009842:Oligopeptides; D010446:Peptide Fragments; C107385:valyl-prolyl-aspartyl-prolyl-arginine; D002784:Cholesterol