TT virus loads and lymphocyte subpopulations in children with acute respiratory diseases.
TT virus (TTV) produces chronic plasma viremia in around 90% of healthy individuals of all ages and has, therefore, been proposed as a commensal human virus. We recently demonstrated that in children hospitalized for acute respiratory diseases high TTV loads were associated with severe forms of disease. Here, we report that in such children TTV loads showed an inverse correlation with the percentage of circulating total T and helper T cells and a direct correlation with the percentage of B cells. Thus, florid TTV replication might contribute to lymphocyte imbalances and, possibly, immunosuppressive effects, thus resembling related animal viruses.
Maggi
Fabrizio
F
Virology Section and Retrovirus Center, Department of Experimental Pathology, University of Pisa, Italy.
Pifferi
Massimo
M
Tempestini
Elena
E
Fornai
Claudia
C
Lanini
Letizia
L
Andreoli
Elisabetta
E
Vatteroni
Marialinda
M
Presciuttini
Silvano
S
Pietrobelli
Angelo
A
Boner
Attilio
A
Pistello
Mauro
M
Bendinelli
Mauro
M
D000208:Acute Disease; D002648:Child; D004279:DNA, Viral / Q000097:blood; D006801:Humans; D016131:Lymphocyte Subsets; D012140:Respiratory Tract Diseases / Q000821:virology*; D022783:Torque teno virus / Q000235:genetics / Q000302:isolation & purification*; D019562:Viral Load
D004279:DNA, Viral