[Platelet membrane Ca(2+) and Na(+), K(+)-ATPase activity and aggregation in myelodysplastic syndrome].
Platelet aggregation was decreased under action of ADP and collagen in patients with myelodysplastic syndrome. The decrease in aggregation started from 3-rd minutes and decreased in 4 and 5 minutes after action of ADP. The study of Ca(2+)-ATPase and Na+, K(+)-ATPase membrane activities showed the decrease in Ca(2+)-ATPase and increase in Na+, K(+)-ATPase activity in the patients with myelodysplastic syndrome.
Bielins'ka
I V
IV
Taras Shevchenko Kyiv National University, Ukraine.
Ostrovs'ka
H V
HV
Rybal'chenko
V K
VK
Koval'chuk
T O
TO
Klymenko
V I
VI
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000166:cytology / Q000201:enzymology*; D000252:Calcium-Transporting ATPases / Q000097:blood / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology*; D003094:Collagen / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D009190:Myelodysplastic Syndromes / Q000201:enzymology*; D010974:Platelet Aggregation / Q000187:drug effects*; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood / Q000378:metabolism*
D000244:Adenosine Diphosphate; D003094:Collagen; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase