Bullous eruption: a manifestation of lupus erythematosus.
Bullous lupus erythematosus (BSLE) is a rare subset of systemic lupus erythematosus (SLE), often associated with autoimmunity to type VII collagen. Generally, patients with BSLE meet the criteria for SLE as defined by the American College of Rheumatology. We present a case of a 17-year-old adolescent girl who presented with a vesiculobullous eruption without detectable type VII collagen antibodies and without full criteria for SLE. Differential staining was characteristic for lupus erythematosus (LE), suggesting her eruption is related to LE. We review the spectrum of bullous disease in patients with LE and discuss the pathogenesis and histology of these eruptions, as well as current therapeutic options.
Harris-Stith
Ronea
R
Goodfellow Air Force Base, Texas, USA.
Erickson
Quenby L
QL
Elston
Dirk M
DM
David-Bajar
Kathleen
K
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D001741:Black or African American; D001707:Biopsy, Needle; D003078:Colchicine / Q000008:administration & dosage; D003622:Dapsone / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D018570:Risk Assessment; D012720:Severity of Illness Index; D012867:Skin / Q000648:ultrastructure; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D003622:Dapsone; D003078:Colchicine