Synthesis of N2 2'-deoxyguanosine adducts formed by 1-nitropyrene.
[reaction: see text] Synthesis of N(2) 2'-deoxyguanosine adducts formed by the ubiquitous carcinogen, 1-nitropyrene, is reported. Various conditions of Buchwald-Hartwig palladium-catalyzed amination are examined. The most convenient synthetic approach involved a straightforward coupling between protected 2'-deoxyguanosine and bromonitropyrenes, which, upon reductive deprotection, provided excellent yield of the two 1-nitropyrene adducts.
Chakraborti
Debasis
D
Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, USA.
Colis
Laureen
L
Schneider
Renee
R
Basu
Ashis K
AK
D003849:Deoxyguanosine / Q000138:chemical synthesis* / Q000737:chemistry; D011721:Pyrenes / Q000737:chemistry*
D011721:Pyrenes; D003849:Deoxyguanosine; C032668:1-nitropyrene