title: [Synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol].
abstract: OBJECTIVE
  To study the synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol.
  
  
  METHODS
  Pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol were synthesized primarily from 2-methyl-5-nitroimidazol, norfloxacin, ciprofloxacin, enoxacin via nucleophilic substitution and esterification. The antibacterial activity of the nine target compounds were tested.
  
  
  RESULTS
  Nine new compounds were synthesized (IIa-c and IIIa-f). The structure of the title compounds were identified by 1HNMR, MS as well as elementary analysis.
  
  
  CONCLUSIONS
  Compounds IIa, IIb and IIc showed antibacterial activity, and were worth further studying.
authors.affiliation: Department of Chemistry, Wenzhou Medical College, Wenzhou 325027, China. YZYFQ-mail@sina.com
authors.forename: Fa-qing
authors.initials: FQ
authors.lastname: Ye
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Jin-min
authors.initials: JM
authors.lastname: Huang
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002939:Ciprofloxacin / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D015365:Enoxacin / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009593:Nitroimidazoles / Q000737:chemistry*; D009643:Norfloxacin / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D009593:Nitroimidazoles; C052586:2-methyl-5-nitroimidazole; D015365:Enoxacin; D002939:Ciprofloxacin; D009643:Norfloxacin