title: [Effects of NaBT and NSAIDs on colorectal adenoma-carcinoma cells].
abstract: OBJECTIVE
  We investigated the primary adenoma cells and HT-29 cells in an attempt to know whether NaBT and two NSAIDs (aspirin and NS-398) could be used as effective adjuvant for reducing cell proliferation, and to explore the possible mechanisms therein involved.
  
  
  METHODS
  MTT was employed in detecting the anti-proliferative effects on both adenoma and HT-29 culture cells.
  
  
  RESULTS
  Both butyrate and NSAIDs could inhibit the proliferation of cells. The effects of the NSAIDs could be synergistically strengthened by combining with butyrate.
  
  
  CONCLUSIONS
  NaBT and the two NSAIDs could inhibit the cell proliferation when used separately, and a combination of butyrate with aspirin or NS-398 could enhance the inhibitory effects.
authors.affiliation: Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Qin
authors.initials: Q
authors.lastname: Ouyang
authors.forename: Huatian
authors.initials: H
authors.lastname: Gan
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000236:Adenoma / Q000473:pathology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001241:Aspirin / Q000494:pharmacology; D002087:Butyrates / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000473:pathology*; D005434:Flow Cytometry / Q000379:methods; D019073:HT29 Cells; D006801:Humans; D009578:Nitrobenzenes / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002087:Butyrates; D009578:Nitrobenzenes; D013449:Sulfonamides; C080955:N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; D001241:Aspirin