title: Fatal disseminated Acremonium strictum infection in a preterm newborn: a very rare cause of neonatal septicaemia.
abstract: Species of the genus Acremonium (Cephalosporium) are opportunistic micro-organisms that are environmentally widespread saprophytes in soil and can, very rarely, be pathogenic in humans. Disseminated infection has been described in patients with immunodeficiency, but has previously been reported in only one neonate. A preterm infant with Acremonium strictum fungaemia is reported here. The patient was born at 27 weeks gestation and weighed 870 g at birth. She needed intensive respiratory management and became septic on day 11 of life. Blood and cerebrospinal fluid (CSF) cultures were positive for A. strictum. The patient did not respond to therapy with amphotericin B plus fluconazole and died on day 25 of life. The autopsy showed foci due to A. strictum in the brain, liver and heart.
authors.affiliation: Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yalaz
authors.affiliation: Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Suleyha
authors.initials: S
authors.lastname: Hilmioglu
authors.affiliation: Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Metin
authors.affiliation: Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Mete
authors.initials: M
authors.lastname: Akisu
authors.affiliation: Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Nart
authors.affiliation: Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Cetin
authors.affiliation: Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozturk
authors.affiliation: Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Ecmel
authors.initials: E
authors.lastname: Isik
authors.affiliation: Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Nilgun
authors.initials: N
authors.lastname: Kultursay
mesh_terms: D000164:Acremonium / Q000302:isolation & purification*; D017809:Fatal Outcome; D005260:Female; D016469:Fungemia / Q000382:microbiology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D009181:Mycoses / Q000382:microbiology*