title: Improving spatiotemporal resolution of USPIO-enhanced dynamic imaging of rat kidneys.
abstract: This paper addresses the problem of enhancing spatiotemporal resolution of ultra-small superparamagnetic iron oxide (USPIO)-enhanced dynamic MRI of rat kidneys. To alleviate the limited resolution problem of conventional full-scan Fourier imaging methods, we use a generalized series-based imaging scheme to reduce coverage of kappa-space. Experimental results demonstrate that the generalized series imaging method with basis functions constructed using two references (pre- and post-contrast) can reduce the number of phase encodings measured during the dynamic contrast wash-in process by a factor of 4 with a negligible or minimal loss of image quality. The method is expected to make 3D studies possible using USPIO-enhanced dynamic imaging of rat kidneys, and prove valuable for early detection of renal rejection after kidney transplantation.
authors.affiliation: Department of Electrical and Computer Engineering Carnegie Mellon University, Pittsburgh, PA, USA.
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.forename: Dewen
authors.initials: D
authors.lastname: Yang
authors.forename: Qing
authors.initials: Q
authors.lastname: Ye
authors.forename: Mangay
authors.initials: M
authors.lastname: Williams
authors.forename: José M F
authors.initials: JM
authors.lastname: Moura
authors.forename: Fernando
authors.initials: F
authors.lastname: Boada
authors.forename: Zhi-Pei
authors.initials: ZP
authors.lastname: Liang
authors.forename: Chien
authors.initials: C
authors.lastname: Ho
mesh_terms: D000818:Animals; D003287:Contrast Media; D003911:Dextrans; D052203:Ferrosoferric Oxide; D006084:Graft Rejection / Q000175:diagnosis; D007091:Image Processing, Computer-Assisted; D007501:Iron; D007668:Kidney / Q000033:anatomy & histology*; D016030:Kidney Transplantation / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D010087:Oxides; D051381:Rats
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D007501:Iron; D052203:Ferrosoferric Oxide