title: Lower risk of Parkinson's disease in an admixed population of European and Indian origins.
abstract: We studied whether the occurrence of Parkinson's disease (PD) in the Anglo-Indians, an admixed population of European and Asian Indian origin, differs from Indians living in the same environment. Epidemiological studies show considerably higher prevalence of PD amongst white compared to non-white populations. Normal Indians contain a approximately 40% lower number of melanized nigral neurons compared to Caucasians from the UK. Anglo-Indians are an admixed population of European and Indian origin. We used the UK Parkinson's Disease Society Brain Bank clinical diagnostic criteria (steps 1 and 2) to diagnose PD in 84 of 493 residents (Indians, 409; Anglo-Indians, 84) living in elderly homes in Bangalore, India. Of these 84, 80 were Indians (19.5%) and 4 were Anglo-Indians (4.8%). Occurrence of PD is nearly five times higher amongst Indians compared to the Anglo-Indians (odds ratio, 3.9; 95% confidence interval, 1.3-12.9). We conclude that an admixture population of European and Indian origins, rather than averaging, might result in reduced occurrences of PD. Hence, studying an admixed population could provide crucial insights into understanding genetic mechanisms in the etiopathogenesis of PD.
authors.affiliation: Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors.forename: Mona
authors.initials: M
authors.lastname: Ragothaman
authors.forename: Uday A
authors.initials: UA
authors.lastname: Murgod
authors.forename: Gopalkrishna
authors.initials: G
authors.lastname: Gururaj
authors.forename: Subbakrishna D
authors.initials: SD
authors.lastname: Kumaraswamy
authors.forename: Uday
authors.initials: U
authors.lastname: Muthane
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005060:Europe / Q000208:ethnology; D005260:Female; D006801:Humans; D007194:India / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000208:ethnology*; D010641:Phenotype; D011157:Population Dynamics; D015995:Prevalence; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology