Synthesis and properties of a new type DNA dendrimer.
We have designed a new type of a DNA dendrimer which has rigid branched structure. The branching molecule was prepared from 1,3,5-tribromobenzene. The dendrimer unit, in which three oligonucleotide-chains, two molecules of T15 and one molecule of A15, linked to the branching molecule, was synthesized by an automated DNA synthesizer. The properties of the dendrimer unit and dendrimer formation by inter-molecular association of T15 and A15 chains of the dendrimer unit will be presented.
Suzuki
Y
Y
Faculty of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
Otomo
T
T
Ozaki
H
H
Sawai
H
H
D001555:Benzene Derivatives; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry*; D015195:Drug Design; D008722:Methods; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry
D001555:Benzene Derivatives; D009838:Oligodeoxyribonucleotides; C055383:1,3,5-tribromobenzene; D004247:DNA