Vaccination with heat shock protein-peptide complexes: from basic science to clinical applications.
There are currently over 150 medical centers worldwide enrolling patients in randomized, controlled Phase III clinical trials testing autologous cancer-derived heat-shock protein (HSP)-peptide complexes for the treatment of renal cell carcinoma and melanoma. In addition, autologous HSP-peptide complexes have been or are being tested in Phase I and II trials of chronic myelogenous leukemia, lymphoma and pancreatic, gastric and colorectal cancers. The door has more recently opened to clinical testing of off-the-shelf HSP-based treatments for infectious diseases. This review recounts the long history of basic research on HSPs in immune response. A keen understanding of how these ancient molecules orchestrate the immune response to cancer and infections has been gained, providing a clear rationale for translating this knowledge into clinical medicine.
Hoos
Axel
A
Antigenics Inc., New York City, NY 10111, USA. ahoos@antigenics.com
Levey
Daniel L
DL
D000818:Animals; D001324:Autoantigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D019496:Cancer Vaccines / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000276:immunology / Q000628:therapy; D002986:Clinical Trials as Topic; D004067:Digestive System Neoplasms / Q000276:immunology / Q000628:therapy; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000276:immunology*; D019337:Hematologic Neoplasms / Q000276:immunology / Q000628:therapy; D006801:Humans; D007113:Immunity, Innate; D016233:Immunotherapy, Active; D007680:Kidney Neoplasms / Q000276:immunology / Q000628:therapy; D051379:Mice; D018832:Molecular Chaperones / Q000276:immunology; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D009928:Organ Specificity; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014611:Vaccination; D022223:Vaccines, Subunit / Q000627:therapeutic use
D001324:Autoantigens; D019496:Cancer Vaccines; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D022223:Vaccines, Subunit