Effect of glyprolines on norepinephrine tone of isolated rat aortic rings.
Glyprolines, short proline-containing peptides (Pro-Gly-Pro, Pro-Gly, and Gly-Pro) in concentrations of 10(-8)-10(-4) M decreased norepinephrine tone of the isolated rat aortic rings. The vasodilatory effect of Pro-Gly-Pro and Pro-Gly was associated with NO release from endotheliocytes, while Gly-Pro directly affected vascular smooth muscle cells.
Bakaeva
Z V
ZV
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University.
Badmaeva
K E
KE
Sergeev
I Yu
IY
Samonina
G E
GE
D000818:Animals; D001011:Aorta / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D042783:Endothelial Cells / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D005998:Glycine / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D011392:Proline / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D014662:Vasoconstrictor Agents / Q000378:metabolism*; D014665:Vasodilator Agents / Q000494:pharmacology*
D010455:Peptides; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009569:Nitric Oxide; D011392:Proline; D005998:Glycine; D009638:Norepinephrine