Novel HLA B*2714 and B*2708 allele associations in seronegative spondarthritis patients and haemophilia patients with chronic synovitis in India.
HLA B27 association with seronegative spondarthritis (SSA) has been recognized for over a decade and its association with chronic synovitis in Haemophilia patients has been recently reported. We characterized the HLA B27 subtypes in a cohort of 98 B27 positive individuals with SSA (n = 45), haemophilia with chronic synovitis (n = 21) and normal controls (n = 32), using polymerase chain reaction-based sequence specific primers (PCR-SSP) and reverse line strip (RLS) techniques. The results revealed a significant association for a novel allele B*2714 in SSA along with the previously reported B*2705 allele. We also found a significant association between haemophilia patients with chronic synovitis from India and a hitherto unidentified allele, B*2708.
Shankarkumar
U
U
HLA department, Institute of Immunohaematology, K.E.M. Hospital, Mumbai, India. Shankarkumar16@hotmail.com
Ghosh
K
K
Mohanty
D
D
D001168:Arthritis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D015235:HLA-B Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen / Q000235:genetics*; D006467:Hemophilia A / Q000235:genetics*; D006801:Humans; D007194:India; D008297:Male; D013585:Synovitis / Q000235:genetics*
D015235:HLA-B Antigens; C090660:HLA-B protein, human; D015796:HLA-B27 Antigen