Cytomegalovirus retinitis and FK 506.
OBJECTIVE
To report a case of cytomegalovirus (CMV) retinitis in a patient immunosuppressed with FK 506.


METHODS
Interventional case report.


METHODS
Retrospective institutional study. One patient, diagnosed with bilateral CMV retinitis while on immunosuppressive treatment with FK 506, received systemic ganciclovir and intravitreal, slow-release ganciclovir implant in one eye, combined with reduction in FK 506 dose. Main outcome measures were visual acuity and regression of CMV retinitis.


RESULTS
Visual acuity at presentation was 20/20 in the right eye and 20/50 in the left eye. During the 6 months of follow-up, there was no change in visual acuity in either eye. The areas of CMV retinitis demonstrated progressive regression, leaving diffuse retinal atrophy.


CONCLUSIONS
Cytomegalovirus retinitis can be a sight-threatening complication of immunosuppressive treatment with FK 506. Ganciclovir treatment together with a reduction in FK 506 dose was effective in preserving vision.
Ciardella
Antonio P
AP
Department of Ophthalmology, Edward S. Harkness Eye Institute, New York Presbyterian Hospital, New York, New York 10032, USA. aciardella@yahoo.com
Barile
Gaetano
G
Langton
Kevin
K
Chang
Stanley
S
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D017726:Cytomegalovirus Retinitis / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D004343:Drug Implants; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation; D009894:Opportunistic Infections / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D012189:Retrospective Studies; D016559:Tacrolimus / Q000627:therapeutic use*; D014792:Visual Acuity
D000998:Antiviral Agents; D004343:Drug Implants; D007166:Immunosuppressive Agents; D015774:Ganciclovir; D016559:Tacrolimus