title: Cutaneous fibropapilloma in a mountain lion (Felis concolor).
abstract: A 12-yr-old mountain lion (Felis concolor) developed a 0.5-cm3 raised nonpigmented and nonulcerated mass between the lip and the nasal planum. The tumor was surgically removed and diagnosed histologically as a fibropapilloma. The tumor recurred 1 yr later, at which time it was again excised, and the diagnosis was reconfirmed by biopsy. Frozen tissue from the second excision was submitted for polymerase chain reaction testing for papillomavirus. The 176-base pair polymerase chain reaction product recovered from the tumor was cloned and sequenced. The papillomavirus had 96% homology with a papillomavirus previously retrieved from a fibropapilloma in a domestic cat and is the next most closely related to bovine papillomavirus type 1. This is the first report of a virus-associated fibropapilloma in a mountain lion.
authors.affiliation: Department of Veterinary Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA.
authors.forename: F Y
authors.initials: FY
authors.lastname: Schulman
authors.forename: A E
authors.initials: AE
authors.lastname: Krafft
authors.forename: T
authors.initials: T
authors.lastname: Janczewski
authors.forename: I
authors.initials: I
authors.lastname: Mikaelian
authors.forename: J
authors.initials: J
authors.lastname: Irwin
authors.forename: K
authors.initials: K
authors.lastname: Hassinger
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D001483:Base Sequence; D002335:Carnivora; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000473:pathology / Q000601:surgery / Q000662:veterinary* / Q000821:virology; D008969:Molecular Sequence Data; D009364:Neoplasm Recurrence, Local / Q000662:veterinary; D010212:Papilloma / Q000473:pathology / Q000601:surgery / Q000662:veterinary* / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D016415:Sequence Alignment; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary* / Q000821:virology