CD34-positive stromal cells in primary lung carcinomas.
To investigate the phenotypes of stromal cells in primary lung carcinomas, we examined the distribution of CD34-positive stromal cells in primary lung carcinomas, with special reference to histological types. In total 26 surgically resected primary lung carcinomas (13 adenocarcinomas, 10 squamous cell carcinomas, 2 large cell carcinomas, and 1 small cell carcinoma and their normal tissues were examined. CD34-positive stromal cells were observed in connective tissue adjacent to the bronchiolar and bronchial epithelium in normal lung tissues. Nine of the 13 adenocarcinomas had CD34-positive stromal cells in the tumor stroma, whereas none of the other histological type tumors examined had CD34-positive stromal cells. These results suggest that CD34-positive stromal cells are specific in the stroma of primary lung adenocarcinomas, and there is a possibility that CD34-positive stromal cells may play a supportive role in primary lung adenocarcinomas.
Nakayama
Hirofumi
H
Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan. nakayamh@hiroshima-u.ac.jp
Enzan
Hideaki
H
Yamamoto
Maya
M
Miyazaki
Eriko
E
Hidaka
Chitoshi
C
Okumichi
Tsuneo
T
Okumichi
Atsuo
A
Kajihara
Hiroki
H
D000230:Adenocarcinoma / Q000378:metabolism*; D018952:Antigens, CD34 / Q000096:biosynthesis*; D018287:Carcinoma, Large Cell / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000096:biosynthesis
D018952:Antigens, CD34; D019408:Platelet Endothelial Cell Adhesion Molecule-1