title: Physicochemical compatibility between ketoprofen lysine salt injections (Artrosilene) and pharmaceutical products frequently used for combined therapy by intravenous administration.
abstract: Ketoprofen lysine salt (Artrosilene) Fiale) is a non-steroidal anti-inflammatory agent frequently administered by intravenous infusion in association regimen with other drugs, such as steroidal anti-inflammatory, anti-hemorrhagic, anti-spastic, anti-ulcer, and antibacterial drugs. The aim of this study was to investigate the physicochemical compatibility between ketoprofen lysine salt (Artrosilene) Fiale) and other injectable drugs frequently used in association. Physicochemical properties of ketoprofen lysine salt mixtures with different drugs, including colour, clarity, pH and drug content were observed or measured before and after (up to 5 h) mixing at room temperature and under light protection. Results show that the association of Artrosilene Fiale with different drugs does not cause, up to 5 h from mixing, any significant variation in the physicochemical parameters mentioned above. In conclusion, the results obtained demonstrated the physicochemical compatibility of ketoprofen lysine salt (Artrosilene) Fiale) with several drugs.
authors.affiliation: Research and Development, L'Aquila Research Centre, Dompé SpA, via Campo di Pile, 67100, L'Aquila, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Anacardio
authors.forename: Orietta
authors.initials: O
authors.lastname: Perilli
authors.forename: Sandro
authors.initials: S
authors.lastname: Bartolini
authors.forename: Marco M
authors.initials: MM
authors.lastname: Gentile
authors.forename: Pietro
authors.initials: P
authors.lastname: Mazzeo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Carlucci
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D007660:Ketoprofen / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry*; D008239:Lysine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004364:Pharmaceutical Preparations; C029946:ketoprofen lysine; D007660:Ketoprofen; D008239:Lysine