Reference values for the geometric centre analysis of colonic transit measurements with 111indium-labelled diethylenetriamine penta-acetic acid.
The geometric centre analysis is often used for evaluating colonic transit data obtained by scintigraphy after oral intake of 111indium-labelled diethylenetriamine penta-acetic acid (111In-DTPA). The purpose of this study was to establish reference values for the geometric centre analysis in adult humans. Forty-eight healthy volunteers (24 women, 24 men) who were equally distributed among three age groups (young, middle-aged, elderly) were studied. In all subjects the geometric centre of radioactivity in the colon was calculated from abdominal gamma camera images acquired 24, 48, 72, and 96 h after oral administration of 111In-DTPA. Overall, the men had a higher geometric centre value than women after both 24 and 48 h indicating a faster progress of colonic contents in men at these time points. At each time point the geometric centre value was higher in both the young and middle-aged subjects than in the elderly subjects, whereas we did not find any difference between young and middle-aged subjects. Furthermore, the smokers had a higher geometric centre value than non-smokers at each time point. The geometric centre value was not influenced by body mass index at any time point.
Madsen
Jan Lysgård
JL
Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, University Hospital of Copenhagen, Denmark. jan.lysgaard.madsen@hh.hosp.dk
Fuglsang
Stefan
S
Graff
Jesper
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003106:Colon / Q000502:physiology*; D003108:Colonic Diseases / Q000000981:diagnostic imaging*; D005260:Female; D015902:Gamma Cameras / Q000592:standards*; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D012016:Reference Values
D004369:Pentetic Acid