Native extracellular matrix coating on Ti surfaces.
Osteoblast-like SAOS-2 cells were allowed to synthesize and assemble their extracellular matrix (ECM) on titanium surfaces. After the selective removal of cells, Ti coated with a native ECM was obtained (ECM-Ti). The responses of SAOS-2 cells to ECM-Ti compared with those to peptide sequence RGDS- or fibronectin-immobilized Ti were examined, demonstrating the compositional and structural effects needed to trigger the native cell behavior.
Pham
Minh T
MT
Forschungszentrum Rossendorf e V, Institut für Ionenstrahlphysik und Materialforschung, Postfach 510119, 01314 Dresden, Deutschland. pham@fz-rossendorf.de
Reuther
Helfried
H
Maitz
Manfred F
MF
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D005109:Extracellular Matrix / Q000737:chemistry* / Q000648:ultrastructure; D006801:Humans; D008856:Microscopy, Fluorescence; D010006:Osteoblasts / Q000502:physiology; D014025:Titanium / Q000737:chemistry*
D014025:Titanium