title: [Study on the distribution of vitamin D receptor gene start codon polymorphism in the Achangs and Hans].
abstract: OBJECTIVE
  To detect the difference between the Chinese Achang and Han ethnic groups in Yunnan province in the distribution of vitamin D receptor (VDR) gene start codon polymorphism.
  
  
  METHODS
  Polymerase chain reaction-restriction fragment length polymorphism, gene sequencing and genetic analysis methods were used. A restriction fragment length polymorphism in the start codon of VDR (Fok I) gene was tested in the Achangs (n=68) and the Hans (n=92).
  
  
  RESULTS
  The frequencies of FF, Ff and ff genotypes were found to be 18%, 35% and 47% in the Achangs, and 22%, 52% and 26% in the Hans, respectively. A significant difference was seen in the frequency distribution of VDR genotype between the Achangs and the Hans(Chi2=7.716, P=0.021).
  
  
  CONCLUSIONS
  The Achang and Han ethnic groups differ in the frequency distribution of VDR gene start codon polymorphism.
authors.affiliation: Clinical Research Center, the First Affiliated Hospital, Kunming Medical College, Kunming, Yunnan, 650032 PR China.
authors.forename: Ji-mei
authors.initials: JM
authors.lastname: Li
authors.forename: Hua-jun
authors.initials: HJ
authors.lastname: Lu
authors.forename: Hai-lin
authors.initials: HL
authors.lastname: Li
authors.forename: Rui-zhu
authors.initials: RZ
authors.lastname: Tang
authors.forename: Xiao-xian
authors.initials: XX
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Hao
mesh_terms: D002681:China; D018387:Codon, Initiator / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018387:Codon, Initiator; D018167:Receptors, Calcitriol