[Study on the genic polymorphism of HLA-DRB1 in a population in the north of China].
OBJECTIVE
To investigate at the DNA level the polymorphism of HLA-DRB1 gene in Han population in Beijing of China.


METHODS
This study was conducted in the Hans in Beijing. A total of 2810 normal and unrelated neonates were analyzed and subjected to HLA-DRB1 low resolution typing, and from among them 217 neonates were randomly selected for DRB1 high resolution typing by polymerase chain reaction-sequence specific primers technique.


RESULTS
Fourteen HLA-DRB1 specificity and 39 alleles were found with HLA-DRB1 *09012, *1501, *07011, *08032 as the most common genes. Their gene frequencies and allelic distributions were compared to those observed in other ethnic populations.


CONCLUSIONS
The results showed the characteristic of HLA-DRB1 distribution, and provided more comprehensive and accurate gene data that may serve as normal reference values for the population in Beijing, China.
Li
Dan
D
HLA Laboratory, People's Hospital and Institute of Hematology, Beijing University, Beijing, 100044 PR China. lee-adan@Yahoo.com.cn
Liu
Hai-yan
HY
Xi
Bin
B
Yu
Yan
Y
D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553509:HLA-DRB1*09:01:02 antigen