Comparison of left ventricular function by echocardiogram in patients with Wilms' tumor treated with anthracyclines versus those not so treated.
The aim of this report was to evaluate late left ventricular function in survivors of Wilms' tumor and to compare patients treated with anthracyclines with those treated without anthracycline and with normal subjects. Wilms' tumor survivors treated without anthracycline had no myocardial abnormalities. A large percentage of patients treated with anthracycline presented with increased end-systolic wall stress. Results indicate that there is a high incidence of subclinical cardiovascular abnormalities in such patients.
Iarussi
Diana
D
Cattedra di Cardiologia, Dipartimento di Scienze Cardio-Chirurgiche, Toraciche e Respiratorie, Naples, Italy. dianal.iarussi@unina2.it
Indolfi
Paolo
P
Pisacane
Carlo
C
Casale
Fiorina
F
Martino
Vincenzo
V
Fusco
Angela
A
De Rosa
Emilia
E
Di Tullio
Maria Teresa
MT
Calabrò
Raffaele
R
D000293:Adolescent; D000328:Adult; D018943:Anthracyclines / Q000627:therapeutic use*; D001837:Body Weights and Measures; D002306:Cardiac Volume / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D012016:Reference Values; D017741:Survivors; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects*; D009396:Wilms Tumor / Q000000981:diagnostic imaging / Q000188:drug therapy*
D018943:Anthracyclines