title: Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.
abstract: Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative beta-proteobacteria that colonize the respiratory tracts of mammals. B. pertussis is a strict human pathogen of recent evolutionary origin and is the primary etiologic agent of whooping cough. B. parapertussis can also cause whooping cough, and B. bronchiseptica causes chronic respiratory infections in a wide range of animals. We sequenced the genomes of B. bronchiseptica RB50 (5,338,400 bp; 5,007 predicted genes), B. parapertussis 12822 (4,773,551 bp; 4,404 genes) and B. pertussis Tohama I (4,086,186 bp; 3,816 genes). Our analysis indicates that B. parapertussis and B. pertussis are independent derivatives of B. bronchiseptica-like ancestors. During the evolution of these two host-restricted species there was large-scale gene loss and inactivation; host adaptation seems to be a consequence of loss, not gain, of function, and differences in virulence may be related to loss of regulatory or control functions.
authors.affiliation: The Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. parkhill@sanger.ac.uk
authors.forename: Julian
authors.initials: J
authors.lastname: Parkhill
authors.forename: Mohammed
authors.initials: M
authors.lastname: Sebaihia
authors.forename: Andrew
authors.initials: A
authors.lastname: Preston
authors.forename: Lee D
authors.initials: LD
authors.lastname: Murphy
authors.forename: Nicholas
authors.initials: N
authors.lastname: Thomson
authors.forename: David E
authors.initials: DE
authors.lastname: Harris
authors.forename: Matthew T G
authors.initials: MT
authors.lastname: Holden
authors.forename: Carol M
authors.initials: CM
authors.lastname: Churcher
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Bentley
authors.forename: Karen L
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authors.lastname: Mungall
authors.forename: Ana M
authors.initials: AM
authors.lastname: Cerdeño-Tárraga
authors.forename: Louise
authors.initials: L
authors.lastname: Temple
authors.forename: Keith
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authors.lastname: James
authors.forename: Barbara
authors.initials: B
authors.lastname: Harris
authors.forename: Michael A
authors.initials: MA
authors.lastname: Quail
authors.forename: Mark
authors.initials: M
authors.lastname: Achtman
authors.forename: Rebecca
authors.initials: R
authors.lastname: Atkin
authors.forename: Steven
authors.initials: S
authors.lastname: Baker
authors.forename: David
authors.initials: D
authors.lastname: Basham
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bason
authors.forename: Inna
authors.initials: I
authors.lastname: Cherevach
authors.forename: Tracey
authors.initials: T
authors.lastname: Chillingworth
authors.forename: Matthew
authors.initials: M
authors.lastname: Collins
authors.forename: Anne
authors.initials: A
authors.lastname: Cronin
authors.forename: Paul
authors.initials: P
authors.lastname: Davis
authors.forename: Jonathan
authors.initials: J
authors.lastname: Doggett
authors.forename: Theresa
authors.initials: T
authors.lastname: Feltwell
authors.forename: Arlette
authors.initials: A
authors.lastname: Goble
authors.forename: Nancy
authors.initials: N
authors.lastname: Hamlin
authors.forename: Heidi
authors.initials: H
authors.lastname: Hauser
authors.forename: Simon
authors.initials: S
authors.lastname: Holroyd
authors.forename: Kay
authors.initials: K
authors.lastname: Jagels
authors.forename: Sampsa
authors.initials: S
authors.lastname: Leather
authors.forename: Sharon
authors.initials: S
authors.lastname: Moule
authors.forename: Halina
authors.initials: H
authors.lastname: Norberczak
authors.forename: Susan
authors.initials: S
authors.lastname: O'Neil
authors.forename: Doug
authors.initials: D
authors.lastname: Ormond
authors.forename: Claire
authors.initials: C
authors.lastname: Price
authors.forename: Ester
authors.initials: E
authors.lastname: Rabbinowitsch
authors.forename: Simon
authors.initials: S
authors.lastname: Rutter
authors.forename: Mandy
authors.initials: M
authors.lastname: Sanders
authors.forename: David
authors.initials: D
authors.lastname: Saunders
authors.forename: Katherine
authors.initials: K
authors.lastname: Seeger
authors.forename: Sarah
authors.initials: S
authors.lastname: Sharp
authors.forename: Mark
authors.initials: M
authors.lastname: Simmonds
authors.forename: Jason
authors.initials: J
authors.lastname: Skelton
authors.forename: Robert
authors.initials: R
authors.lastname: Squares
authors.forename: Steven
authors.initials: S
authors.lastname: Squares
authors.forename: Kim
authors.initials: K
authors.lastname: Stevens
authors.forename: Louise
authors.initials: L
authors.lastname: Unwin
authors.forename: Sally
authors.initials: S
authors.lastname: Whitehead
authors.forename: Bart G
authors.initials: BG
authors.lastname: Barrell
authors.forename: Duncan J
authors.initials: DJ
authors.lastname: Maskell
mesh_terms: D001483:Base Sequence; D001884:Bordetella / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D016950:Bordetella bronchiseptica / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D001886:Bordetella pertussis / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D004269:DNA, Bacterial; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D013045:Species Specificity
chemical_list: D004269:DNA, Bacterial