[Plasma haemostatic and fibrinolytic activities and their relationship to levels of serum lipids and apolipoproteins in endogenous hypertriglyceridemic patients].
OBJECTIVE
To investigate the changes of plasma haemostatic and fibrinolytic activities and their relationship to serum lipids and apolipoproteins levels in endogenous hypertriglyceridemic patients.


METHODS
We determined the plasma prothrombin time(PT), activated partial thromplastin time(APTT), activity of tissue-type plasminogen activator(t-PA), activity of plasminogen activator inhibitor-1 (PAI-1) and fibrinogen(Fg) level of 24 endogenous hyper-triglyceridemic patients and 34 healthy controls, and observed their relationship to serum lipids and apolipoproteins.


RESULTS
The PT and APTT of patients with hypertriglyceridemia were obviously shorter than those of control subjects (P < 0.01, P < 0.05); PAI-1 of patients was significant higher than that of control group (P < 0.01); there was no statistically significant difference in t-PAI-1: a between the control subjects and the hypertriglyceridemic patients; the levels of Fg in patients was 27% higher than that in healthy control (P < 0.01). The correlation analysis indicated that PT was significantly associated with the levels of plasma HDL-C (r = 0.445, P < 0.01), and inversely associated with the levels of plasma TG, apoC III, BG and BMI (r = -0.294, -0.320, -0.282, -0.272, P < 0.05); APTT was negatively correlated with serum TG and apoC III levels (r = -0.345, -0.320, P < 0.05); t-PA was negatively correlated with BG levels (r = -0.336, P < 0.01). PAI-1 and Fg levels were strongly correlated with serum TG, apoC II, C III and E levels (r = 0.400, 0.408, 0.497, 0.454, P < 0.01 and r = 0.642, 0.581, 0.673, 0.304, P < 0.01, respectively), and negatively correlated with HDL-C (r = -0.366, -0.524, P < 0.01).


CONCLUSIONS
Increasing of coagulating activity and decreasing of fibrinolytic activity in hypertriglyceridemic patients were significantly associated with serum lipids and apolipoproteins levels.
Shen
Tao
T
Apolipoprotein Research Unit, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Bai
Huai
H
Liu
Bingwen
B
Liu
Yu
Y
Zhang
Zuhui
Z
Deng
Zuyue
Z
D001053:Apolipoproteins / Q000097:blood; D005342:Fibrinolysis; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood* / Q000150:complications; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D019851:Thrombophilia / Q000097:blood* / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D017395:Plasminogen Activator Inhibitor 1; D014280:Triglycerides; D010959:Tissue Plasminogen Activator