Gastrocystoplasty in pigs and effect of selective antral vagotomy on acid secretion of the reconstructed bladder.
BACKGROUND
The aim of this study was to investigate the outcome of gastrocystoplasty and the effects of selective antral vagotomy (SAV) on the postprandial gastrin secretion from the antrum as well as on the acid secretion from the augmented bladder.


METHODS
In this study on 12 male pigs, we applied subtotal cystectomy plus gastric augmentation plus SAV to the study group and the same procedure without SAV to the control group. The animals were followed up for 3 months with respect to feeding, weight, and urine output. The urine pH levels and the gastrin levels of the pigs in the two groups were then followed up and compared.


RESULTS
The use of gastric segments in bladder reconstruction was found to be appropriate in terms of both gastric function and urinary system function. Nevertheless, regarding the effect of SAV, the differences between either the urinary pH levels or the gastrin levels of the pigs in the two groups were statistically significant.


CONCLUSIONS
Although gastric segments in the bladder reconstruction were found to be appropriate in terms of both gastric function and urinary system function, SAV did not prevent postprandial gastrin secretion and the resulting increase of the urine acidity.
Acar
O
O
Department of Urology, Kocaeli University Medical Faculty, Kocaeli, Turkey. oguzacar@superonline.com
Demirtas
M
M
Kacar
S
S
Vural
P
P
Devecioglu
Y
Y
Saroglu
M
M
Culha
M
M
Gökalp
A
A
D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism*; D008297:Male; D011706:Pyloric Antrum / Q000378:metabolism; D019651:Plastic Surgery Procedures; D013270:Stomach / Q000601:surgery*; D013552:Swine; D001743:Urinary Bladder / Q000378:metabolism / Q000601:surgery*; D014629:Vagotomy, Proximal Gastric
D005755:Gastrins