[Studies on the chemical constituents of the aerial part of Cimicifuga foetida L].
OBJECTIVE
To look for new active constituents from the aerial part of Cimicifuga foetida L.


METHODS
Various column chromatographic techniques were used for the isolation and purification of the principles. The structures were elucidated on the basis of spectral data and chemical evidences.


RESULTS
Five 9,19-cycloartane triterpenoid saponins and one sitosterol saponin were obtained and identified as cimifoetiside I [12 beta-hydroxycimigenol-3-O-beta-D-galactoyranoside, (1)], cimifoetiside II [(23R,24R) cimigenol-3-O-beta-D-galactopyranoside, (2)], cimigenol-3-O-beta-D-galactopyranoside (3), 12 beta-hydroxycimigenol-3-O-beta-D-xylopyranoside (4), 12 beta-hydroxycimigenol-3-O-alpha-L-arabinopyranoside (5), daucosterol (6).


CONCLUSIONS
Compounds 1 and 2 are new and compounds 4 and 5 were isolated from this plant for the first time.
Pan
Rui-le
RL
Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China.
Chen
Di-hua
DH
Si
Jian-yong
JY
Zhao
Xiao-hong
XH
Shen
Lian-gang
LG
D031885:Cimicifuga / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification*
D004365:Drugs, Chinese Herbal; D012855:Sitosterols; C483647:cimifoetiside I; C483648:cimifoetiside II; C011015:lyoniside