Association between low-density lipoprotein receptor-related protein gene, butyrylcholinesterase gene and Alzheimer' s disease in Chinese.
OBJECTIVE
To research the relations between low-density lipoprotein receptor-related protein gene (LRP) polymorphism, butyrylcholinesterase gene (BchE) polymorphism and Alzheimer's disease (AD) in Chinese.


METHODS
The gene polymorphisms of LRP and BchE were genotyped in 38 AD cases and 40 controls with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. AD groups were classified according to the LRP C/C genotype and compared with matched controls.


RESULTS
AD group had higher frequencies of C/C homozygote (81.69% vs 60.0%, P < 0.05) and of C allele (89.5% vs 76.3%, P < 0.05), with no significant difference between any of these LRP genotypes classified AD groups and their respective control groups.


CONCLUSIONS
A positive correlation was found between LRP gene polymorphism and AD, but not between BchE gene polymorphism and AD in Chinese AD cases.
Bi
S
S
Department of Neurology, First Clinical College of Harbin Medical University, Harbin 150001. bisheng98@sina.com
Zhang
Y
Y
Wu
J
J
Wang
D
D
Zhao
Q
Q
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D044466:Asian People; D002091:Butyrylcholinesterase / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D026503:Low Density Lipoprotein Receptor-Related Protein-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged
D026503:Low Density Lipoprotein Receptor-Related Protein-1; D002091:Butyrylcholinesterase