Histological and immunohistochemical study of a neuroblastoma in a dog.
A 13-year-old, male German Shepherd dog was euthanasized for a frontal temporal mass revealed by the MRI. The histological examination showed a proliferation composed of small round undifferentiated cells arranged in sheets or nests and sometimes in pseudorosettes interrupted by hypocellular zones of fibrovascular stroma. Immunohistochemical studies revealed the expression of neuroblastic epitopes. The presented neoplasm has many histological and immunohistochemical features in common with the group of olfactory neuroblastomas reported in man, so it could be classified as primitive neuroectodermal tumor with neuronal differentiation.
Capucchio
M T
MT
Department of Animal Pathology, Faculty of Veterinary Medicine, University of Turin, Grugliasco, Italy. capucchio@veter.unito.it
Lotti
D
D
Cornaglia
E
E
Valenza
F
F
Schiffer
D
D
D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D005625:Frontal Lobe / Q000378:metabolism / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009447:Neuroblastoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D016900:Neurofilament Proteins / Q000378:metabolism; D009830:Olfactory Bulb / Q000378:metabolism / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
D005904:Glial Fibrillary Acidic Protein; D016900:Neurofilament Proteins; D009418:S100 Proteins; D014746:Vimentin; D010751:Phosphopyruvate Hydratase