[Genome-wide scanning for susceptibility genes in researches on six HLA-associated diseases].
Six human leucocytic antigen(HLA)-associated diseases, including ankylosing spondylitis, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, type 1 diabetes mellitus and psoriasis, were selected as objects of this review. The characteristics of these diseases in whole-genome scans on susceptibility genes or loci undertaken to date were analyzed and compared. Meanwhile, the potential proposals for dealing with the existing problems were put forward.
Gu
Ming-min
MM
Department of Medical Genetics, Shanghai Second Medical University, Shanghai, 200025 PR China. mingmingu@hotmail.com
Wang
Zhu-gang
ZG
Huang
Wei
W
Fan
Li-an
LA
D001172:Arthritis, Rheumatoid / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods*; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics; D011565:Psoriasis / Q000235:genetics; D013167:Spondylitis, Ankylosing / Q000235:genetics
D006680:HLA Antigens