Hip dysplasia in Charcot-Marie-Tooth disease: report of a family.
Charcot-Marie-Tooth disease is classified into hereditary motor and sensory neuropathy (HMSN) types I and II, and affected patients present with progressive peripheral neuropathy. Some previous orthopedic studies have revealed the association of hip dysplasia with HMSN, in addition to pes cavovarus, scoliosis, and recurrent dislocation of the patella. We describe three patients from the same family who were each diagnosed as having HMSN type I with associated bilateral severe hip dysplasia, borderline abnormalities of both acetabula, and dysplastic osteoarthritis. Based on our experience with these patients and a review of previous reports, we concluded that routine screening of hip joints, especially for those with a family history of HMSN, is necessary for early diagnosis.
Ushiyama
Toshio
T
Department of Orthopaedic Surgery, Shiga University of Medical Science, Seta, Otsu, 520-2192, Japan.
Tanaka
Chiaki
C
Kawasaski
Taku
T
Matsusue
Yoshitaka
Y
D000328:Adult; D002607:Charcot-Marie-Tooth Disease / Q000150:complications* / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D006617:Hip Dislocation / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009035:Mothers; D035781:Siblings