[Lipids disorder, macrovascular diseases, and insulin resistance in Chinese diabetic patients].
OBJECTIVE
To investigate the types of lipid disorder and its relationship with macrovascular diseases and insulin resistance in Chinese diabetic patients.


METHODS
2,430 diabetic patients finished the diabetes complications assessment and were surveyed on their blood lipids, insulin level and macrovascular diseases. The insulin resistance (HOMA-IR) was calculated based on HOMA model.


RESULTS
Prevalence of lipids disorder was as high as 63.8% in this group, including 23.9% with both hypercholesterolemia and hypertriglyceridemia (HY-C-T), 16.1% with hypercholesterolemia only (HY-C), 15.0% with hypertriglyceridemia only (HY-T), 5.5% with lower HDL level (L-HDL), 3.3% with hypercholesterolemia, hypertriglyceridemia and lower HDL level together. Compared with the patients with normal lipid level (control group), no duration differences existed among these groups. There were more female patients in HY-C and HY-C-T groups. BMI and WHR were higher in all groups with lipid disorder except in HY-C group. Macrovascular diseases were more common in HY-C-T patients than in control group (33.6% vs 24.0%, P < 0.001). Average blood pressure and the prevalence of hypertension were significantly higher in HY-C-T, HY-C, HY-T groups than in control group (139/79, 138/76, 134/77 vs. 132/75 mmHg; 53.2%, 50.1%, 46.2% vs. 39.2%). Fasting insulin level was significantly higher in HY-C-T and HY-C-T-L-LDL groups than in controls. Insulin resistance was more severe in all patients with lipid disorder except in L-HDL group, particularly in the HY-C-T-L-HDL group.


CONCLUSIONS
(1) BMI, WHR increased significantly with the severity of lipid disorder. (2) Nearly two thirds of Chinese diabetic patients have lipid disorder, which is the strong risk factor of macrovascular diseases and aggravates insulin resistance. (3) There was severe insulin resistance in patients with hypertriglyceridemia or with hypertriglyceridemia plus other lipid disorder.
Xu
Zhang-rong
ZR
Diabetes Center, 306 Hospital of PLA, Beijing 100101, China. xzhr@95777.com
Wang
Yu-zhen
YZ
Jing
Hua
H
Liu
Yan-jun
YJ
Huang
Lie-jun
LJ
Wu
Chun-rong
CR
Yang
Wen-sheng
WS
Yang
Jin-de
JD
Song
Wei
W
Wang
Ai-hong
AH
D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D048909:Diabetes Complications; D003928:Diabetic Nephropathies / Q000209:etiology; D003930:Diabetic Retinopathy / Q000209:etiology; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology / Q000209:etiology*; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D015995:Prevalence