title: [Inverse association between smoking and idiopathic Parkinson's disease].
abstract: An evaluation is made of the effect of smoking during the period of life between 20 and 50 years of age and idiopathic Parkinson's disease in a case-control study carried out in Navarra. An inverse association is observed: for the number of smokers (OR = 0.66, CI 90% 0.41-1.05); for the number of years smoking (OR =0.22, CI 90% 0.05-0.97); and for the quantity of cigarettes smoked (z = 2.2298, p = 0.02). Likewise, a dose-response relationship exists between the number of cigarettes consumed and the risk of Parkinson's disease (p = 0.01). The same effect is maintained on analysing the data by matching 1:1 (OR = 0.59, CI 90% 0.31-1.10). All of this contributes to giving consistency to the protective effect of smoking against idiopathic Parkinson's disease. The anti-oxidant status, measured by means of different parameters in peripheral blood, is lower in the cases than in the tests for reduced glutathione (GSH) (p = 0.001) and is an independent variable with respect to smoking.
authors.affiliation: Servicio Docencia, Investigación y Desarrollo Sanitarios, Gobierno de Navarra, Pamplona.
authors.forename: R
authors.initials: R
authors.lastname: Larumbe
authors.forename: J J
authors.initials: JJ
authors.lastname: Viñes
authors.forename: F
authors.initials: F
authors.lastname: Guillén
authors.forename: I
authors.initials: I
authors.lastname: Gaminde
authors.forename: M T
authors.initials: MT
authors.lastname: Artácoz