title: Reference values for the geometric centre analysis of colonic transit measurements with 111indium-labelled diethylenetriamine penta-acetic acid.
abstract: The geometric centre analysis is often used for evaluating colonic transit data obtained by scintigraphy after oral intake of 111indium-labelled diethylenetriamine penta-acetic acid (111In-DTPA). The purpose of this study was to establish reference values for the geometric centre analysis in adult humans. Forty-eight healthy volunteers (24 women, 24 men) who were equally distributed among three age groups (young, middle-aged, elderly) were studied. In all subjects the geometric centre of radioactivity in the colon was calculated from abdominal gamma camera images acquired 24, 48, 72, and 96 h after oral administration of 111In-DTPA. Overall, the men had a higher geometric centre value than women after both 24 and 48 h indicating a faster progress of colonic contents in men at these time points. At each time point the geometric centre value was higher in both the young and middle-aged subjects than in the elderly subjects, whereas we did not find any difference between young and middle-aged subjects. Furthermore, the smokers had a higher geometric centre value than non-smokers at each time point. The geometric centre value was not influenced by body mass index at any time point.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, University Hospital of Copenhagen, Denmark. jan.lysgaard.madsen@hh.hosp.dk
authors.forename: Jan Lysgård
authors.initials: JL
authors.lastname: Madsen
authors.forename: Stefan
authors.initials: S
authors.lastname: Fuglsang
authors.forename: Jesper
authors.initials: J
authors.lastname: Graff
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003106:Colon / Q000502:physiology*; D003108:Colonic Diseases / Q000000981:diagnostic imaging*; D005260:Female; D015902:Gamma Cameras / Q000592:standards*; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D012016:Reference Values
chemical_list: D004369:Pentetic Acid