title: Timed Pediatric Risk of Mortality Scores predict outcomes in pediatric liver transplant recipients.
abstract: More reliable methods are needed to identify children at risk for poor outcomes following liver transplantation. The Pediatric Risk of Mortality (PRISM) Score is a physiology-based scoring system used to quantify risk of mortality in pediatric intensive care unit (ICU) populations. We evaluated the PRISM Score as a predictor of outcomes including survival in the pediatric liver transplant (LT) population. We retrospectively reviewed the records of 67 consecutive LTs performed between August 1997 and February 2000 at an urban, tertiary children's hospital in Chicago, IL, USA. Four PRISM Scores were calculated to determine which periods were most meaningful. A Classic PRISM Score was calculated during first 24 h of ICU admission, and three PRISM Scores were timed with the patient's transplant: a pre-LT PRISM Score (24 h prior to transplant whether in ICU or not), a 24-h post-LT PRISM Score and a 48-h post-LT PRISM Score. These PRISM Scores and other predictors including transplant number, UNOS status and PELD Score were compared with outcomes including survival using univariate methods. The pre-LT, the 24- and the 48-h PRISM Score were associated with the post-LT number of ventilated days (p < 0.05), ICU days (p < 0.05) and with 1-yr survival (p < 0.04). The PRISM Scores were not related to the post-LT hospital length of stay (LOS) or to 1-yr re-transplantation. The PELD Score correlated with the post-LT hospital LOS, but was not associated with mortality or with the ICU LOS. A patient's UNOS status and Classic PRISM Score were not associated with any of the outcomes measured. PRISM Scores are valid predictors of outcome including survival in pediatric LT recipients. These findings help to demonstrate the importance in this population of a patient's general physiologic condition and its influence on the overall hospital course and survival.
authors.affiliation: Department of Pediatrics, Children's Memorial Hospital and Northwestern University Medical School, Chicago, IL, USA. ccarroll@ccmckids.org
authors.forename: C L
authors.initials: CL
authors.lastname: Carroll
authors.forename: D M
authors.initials: DM
authors.lastname: Goodman
authors.forename: R A
authors.initials: RA
authors.lastname: Superina
authors.forename: P F
authors.initials: PF
authors.lastname: Whitington
authors.forename: E M
authors.initials: EM
authors.lastname: Alonso
mesh_terms: D000293:Adolescent; D002641:Chicago / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D006776:Hospitals, Pediatric / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007902:Length of Stay; D016031:Liver Transplantation / Q000401:mortality*; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D012121:Respiration, Artificial; D012189:Retrospective Studies; D018570:Risk Assessment