Delineating the sites and progression of in vivo atrophy in multiple system atrophy using fluid-registered MRI.
We describe the pattern and progression of atrophy delineated using fluid registration of serial magnetic resonance imaging scans in a case of multiple system atrophy (MSA). The in vivo findings were consistent with those found at postmortem, including significant supratentorial atrophy concurrent with an unusual degree of cognitive impairment for MSA.
Schott
Jonathan M
JM
Dementia Research Group, Institute of Neurology, London, United Kingdom.
Simon
Jessica E
JE
Fox
Nick C
NC
King
Andrew P
AP
Khan
M Nadeem
MN
Cipolotti
Lisa
L
Paviour
Dominic C
DC
Stevens
John M
JM
Rossor
Martin N
MN
D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000150:complications / Q000473:pathology*; D009483:Neuropsychological Tests