[Aging features of L-thyroxine action on glycosylphosphatidylinositol metabolism in rat liver].
L-thyroxine action on GPI and phosphatidylinositol (PI) metabolism in the liver have been investigated in 3- and 24-month-old Wistar rats. PI and GPI were labeled by [14C]acetate Na in vivo and [14C]glucose in vitro. Aging caused a significant decrease in basal PI and GPI levels and reduced [14C]glucose incorporation into GPI of liver. The addition of exogenous PI stimulated the [14C]GPI formation (about 2-3 fold) in 24-month-old rat liver. Thyroxine injection (200 micrograms/100 g weight) to young rats induced triphasic alteration in GPI content in the liver. We observed the marked violation in the thyroxine-mediated GPI-metabolism in the old rats liver. These results indicate that thyroid hormones regulate GPI metabolism in rat liver.
Krasil'nikova
O A
OA
Karazin University, Kharkov, Ukraine.
Kavok
N S
NS
Nikitina
I V
IV
Babenko
N A
NA
D000085:Acetates / Q000378:metabolism; D000375:Aging; D000818:Animals; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism; D017261:Glycosylphosphatidylinositols / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000494:pharmacology*
D000085:Acetates; D017261:Glycosylphosphatidylinositols; D010716:Phosphatidylinositols; D005947:Glucose; D013974:Thyroxine