title: Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish.
abstract: Selenium is important for embryogenesis in vertebrates but little is known about the expression patterns and biological functions of most selenoprotein genes. Taking advantage of the zebrafish model, systematic analysis of selenoprotein gene expression was performed by in situ hybridization on whole-mount embryos at different developmental stages. Twenty-one selenoprotein mRNAs were analyzed and all of them exhibited expression patterns restricted to specific tissues. Moreover, we demonstrated that highly similar selenoprotein paralogs were expressed within distinct territories. Therefore, tissue- and development-specific expression patterns provided new information for selenoproteins of unknown function.
authors.affiliation: Institut de Génétique et Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur, 1 rue Laurent Fries, BP 10142, CU de Strasbourg, 67404 Illkirch, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Thisse
authors.forename: Agnès
authors.initials: A
authors.lastname: Degrave
authors.forename: Gregory V
authors.initials: GV
authors.lastname: Kryukov
authors.forename: Vadim N
authors.initials: VN
authors.lastname: Gladyshev
authors.forename: Sophie
authors.initials: S
authors.lastname: Obrecht-Pflumio
authors.forename: Alain
authors.initials: A
authors.lastname: Krol
authors.forename: Bernard
authors.initials: B
authors.lastname: Thisse
authors.forename: Alain
authors.initials: A
authors.lastname: Lescure
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D015347:RNA Probes; D012333:RNA, Messenger / Q000378:metabolism; D051140:Selenoproteins; D014018:Tissue Distribution; D015027:Zebrafish / Q000196:embryology*; D029961:Zebrafish Proteins
chemical_list: D011506:Proteins; D015347:RNA Probes; D012333:RNA, Messenger; D051140:Selenoproteins; D029961:Zebrafish Proteins; C495236:selenop protein, zebrafish; C495237:selenop2 protein, zebrafish