title: Reversion of 'early worsening' of diabetic retinopathy by deliberate restoration of poor metabolic control.
abstract: Acutely lowering long-standing severe hyperglycaemia can trigger progression ('early worsening') of diabetic retinopathy, most likely by up-regulation of the circulating insulin-like growth factor 1 (IGF-1). This condition, also called 'florid retinopathy', rarely responds to standard laser coagulation treatment. In this retrospective report, 2 young patients with type 2 diabetes are described, in whom deliberate restoration of poor diabetes control reduced the serum IGF-1 levels and improved 'early worsened' diabetic retinopathy.
authors.affiliation: Diabetesambulanz MNR-Klinik, Heinrich Heine University, Düsseldorf, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Chantelau
authors.forename: R
authors.initials: R
authors.lastname: Meyer-Schwickerath
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D005260:Female; D005451:Fluorescein Angiography; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy* / Q000503:physiopathology*; D007328:Insulin / Q000627:therapeutic use; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D012189:Retrospective Studies; D015854:Up-Regulation; D014792:Visual Acuity
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D007334:Insulin-Like Growth Factor I