6-(Levulinyloxymethyl)-3-methoxy-2-nitrobenzoyl and 2-(levulinyloxymethyl)-5-methoxy-4-nitrobenzoyl groups as novel base-labile groups for 5'-hydroxy protection in solid-phase oligonucleotide synthesis.
The 6-(levulinyloxymethyl)-3-methoxy-2-nitrobenzoyl (LMMoNBz) and 2-(levulinyloxymethyl)-5-methoxy-4-nitrobenzoyl (LMMpNBz) groups were developed as novel base-labile groups for 5'-hydroxy protection in solid-phase oligonucleotide synthesis. A comparative study of the utility of LMMoNBz, LMMpNBz, and 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBz) groups is described.
Kamaike
Kazuo
K
School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan. kamaikek@ps.toyaku.ac.jp
Namiki
Takashi
T
Kawashima
Etsuko
E
D002851:Chromatography, High Pressure Liquid; D007982:Levulinic Acids / Q000737:chemistry*; D009578:Nitrobenzenes / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
C482612:2-(levulinyloxymethyl)-5-methoxy-4-nitrobenzoyl; C482611:6-(levulinyloxymethyl)-3-methoxy-2-nitrobenzoyl; D007982:Levulinic Acids; D009578:Nitrobenzenes; D009841:Oligonucleotides