Embolization of experimental aneurysms using a heparin-loaded stent graft with micropores.
OBJECTIVE
For percutaneous transluminal angioplasty (PTA), a heparin-loaded stent graft, composed of a commercially available metallic stent with a microporous and surface-modified thin film, has been developed. Early controlled endothelialization is promoted by a regular array of micropores produced by an excimer laser ablation technique. Early thrombus is prevented by a drug delivery system established by impregnation of photoreactive gelatin with heparin. Our stent grafts were used for embolization of experimental carotid aneurysms with an autologous external jugular vein patch in dogs.


METHODS
At 1 month after formation, the aneurysms were occluded with stent grafts. Affected arteries were removed with the aneurysms, immediately (two aneurysms in one dog), 1 week (four aneurysms in two dogs), 1 month (three aneurysms in two dogs) and 3 months (four aneurysms in two dogs) after embolization, and were studied histologically to evaluate patency and endothelialization over the intraluminal surface of the thin film.


RESULTS
Treated carotid arteries were all patent with occluded aneurysms completely at any periods. Even at 1 week after embolization, endothelialization was confirmed on the surface of the stent graft on the lumen side. At 1 and 3 months, all treated aneurysms with enough patent parent arteries were filled with organized tissues and completely occluded.


CONCLUSIONS
Our developed stent graft appears to be promising for the treatment of aneurysms, especially with respect to immediate termination of blood inflow and early endothelialization in the neck of the aneurysm.
Nishi
Shogo
S
Department of Neurosurgery, Takatsuki Red Cross Hospital, 1-1-1 Abuno, Takatsuki, Osaka 569-1096, Japan. snishi@ja3.so-net.ne.jp
Nakayama
Yasuhide
Y
Ueda-Ishibashi
Hatsue
H
Matsuda
Takehisa
T
D000783:Aneurysm / Q000628:therapy*; D000818:Animals; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation*; D002340:Carotid Artery Diseases / Q000628:therapy*; D004285:Dogs; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D005343:Fibrinolytic Agents; D006493:Heparin / Q000627:therapeutic use; D023421:Models, Animal; D015607:Stents
D005343:Fibrinolytic Agents; D006493:Heparin