Gli proteins and the control of spinal-cord patterning.
The secreted protein sonic hedgehog (Shh) is crucial for the specification of neuronal subtype identity in the vertebrate neural tube. Zinc-finger proteins of the Gli family are known to be transcriptional mediators of Shh signalling, and to coordinately pattern the dorsal-ventral axis of the spinal cord. Recent studies indicate that additional signals may provide positional information in parallel to Shh to specify neuronal fate in this tissue. We review the role of Gli proteins in spinal-cord development and propose that various upstream patterning signals may be integrated by the Gli proteins to direct a coherent programme of neurogenesis.
Jacob
John
J
Division of Developmental Neurobiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.
Briscoe
James
J
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002490:Central Nervous System / Q000196:embryology* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins / Q000378:metabolism; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013116:Spinal Cord / Q000196:embryology* / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D000071676:Zinc Finger Protein GLI1; D000075746:Zinc Finger Protein Gli2; D000074290:Zinc Finger Protein Gli3
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C082593:GLI2 protein, human; C065683:GLI3 protein, human; C000618551:Gli2 protein, mouse; C465571:Gli3 protein, mouse; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins; D051741:Kruppel-Like Transcription Factors; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D012097:Repressor Proteins; C509239:SHH protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1; D000075746:Zinc Finger Protein Gli2; D000074290:Zinc Finger Protein Gli3; C092937:ci protein, Drosophila