title: Meningio-angiomatosis in a patient with focal epilepsy: value of PET in diagnoses and preoperative planning of surgery.
abstract: A 17-year-old boy with epileptic seizures due to meningio-angiomatosis without neurofibromatosis type 2 is presented. Low grade astrocytoma in the left temporal lobe was resected when he was 11 years old. A recurrence was suspected on following-up MRI and a positive PET scan with 11C-methionine PET 6 years later around the resected area. The language area was mapped using H2(15)O PET activation technique. The lesion was completely resected while preserving the verbal area assisted by three-dimensional imaging protocol of MR-registered PET. The patient was well and seizure-free for 8 years thereafter without antiepileptic drugs. Histologically, there was an increase of dilated arterioles and meningothelial cell-like spindle cells around them, which are characteristic pathological features of meningio-angiomatosis. It is most likely that angiomatous tissue developed perivascular meningiomatous components and formed the meningio-angiomatosis in our presented case. In addition, we presented our protocol of functional neuro-imaging which was useful in terms of the functional neurosurgery.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan. ohtay@tdmc.hosp.go.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Ohta
authors.forename: T
authors.initials: T
authors.lastname: Nariai
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: K
authors.initials: K
authors.lastname: Ishiwata
authors.forename: M
authors.initials: M
authors.lastname: Senda
authors.forename: R
authors.initials: R
authors.lastname: Okeda
authors.forename: K
authors.initials: K
authors.lastname: Ohno
authors.forename: K
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D000293:Adolescent; D000798:Angiomatosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery; D001927:Brain Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery; D002648:Child; D002985:Clinical Protocols; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging* / Q000209:etiology / Q000601:surgery*; D006801:Humans; D008297:Male; D008578:Meninges / Q000000981:diagnostic imaging* / Q000601:surgery; D011300:Preoperative Care; D015203:Reproducibility of Results; D014055:Tomography, Emission-Computed