title: Antipyretic properties of the aqueous and ethanol extracts of the leaves of Ocimum suave and Ocimum lamiifolium in mice.
abstract: Numerous plant species are used to treat ailments associated with pyrexia in the indigenous health care delivery system of Ethiopia. Notable among these are Ocimum suave and Ocimum lamiifolium. The objective of the present study was thus to evaluate the antipyretic effects of the aqueous and ethanol extracts of the leaves of Ocimum suave and Ocimum lamiifolium in mice. Rectal temperatures were recorded before and after inducing pyrexia as well as after administration of the respective extracts every half an hour for 3h. Parallel experiments were run with a standard antipyretic (acetylsalicylic acid) and the vehicle (distilled water). All the plant extracts showed antipyretic property with reasonable onset and duration of action. Both ethanol and aqueous extracts of Ocimum suave were observed to be more potent than those of Ocimum lamiifolium. Aqueous extract of Ocimum suave and ethanol extract of Ocimum lamiifolium were more potent than their other counterpart extracts. Time dependent antipyretic effect was also observed with some extracts; reduced with time with aqueous extract of Ocimum suave and increased with time with both extracts of Ocimum lamiifolium.
authors.affiliation: Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia. eyasumakonnen@yahoo.com
authors.forename: Eyasu
authors.initials: E
authors.lastname: Makonnen
authors.forename: Asfaw
authors.initials: A
authors.lastname: Debella
authors.forename: Legesse
authors.initials: L
authors.lastname: Zerihun
authors.forename: Dawit
authors.initials: D
authors.lastname: Abebe
authors.forename: Frehiwot
authors.initials: F
authors.lastname: Teka
mesh_terms: D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D000431:Ethanol; D005002:Ethiopia; D005334:Fever / Q000139:chemically induced* / Q000188:drug therapy*; D051379:Mice; D031339:Ocimum; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000493:pharmacokinetics*; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal; D014867:Water; D015002:Yeast, Dried / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D014867:Water; D000431:Ethanol