[Detection of eosinophil cationic protein and E-selectin in serum and nasal lavage fluid in patients with allergic rhinitis].
OBJECTIVE
To evaluate the role of eosinophil cationic protein (ECP) and serum soluble E-selectin (sE-selectin) in patients with allergic rhinitis.


METHODS
The sE-selectin were detected from 30 allergic patients and 20 normal individuals by enzyme-linked immunosorbent assay (ELISA). The ECP in serum and nasal lavage fluid was assayed with pharmacia CAP system.


RESULTS
The level of sE-selectin in patients with allergic rhinitis was(41.846 +/- 12.21) ng/ml, higher than that in control (10.678 +/- 2.458) ng/ml. The level of ECP in serum and nasal lavage fluid from patients with allergic rhinitis was significantly higher than that from normal controls. The level of ECP in nasal lavage fluid was much higher than that in serum.


CONCLUSIONS
ECP and sE-selectin play a role in pathogenesis of allergic rhinitis.
Hong
Su-ling
SL
Department of Otorhinolaryngology, First Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China.
Liu
Qing
Q
Huang
Jiang-ju
JJ
Yang
Yu-cheng
YC
Kang
Hou-yong
HY
Wang
Yi-qin
YQ
Sun
Rong
R
D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000032:analysis* / Q000502:physiology; D019040:E-Selectin / Q000032:analysis* / Q000502:physiology; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000737:chemistry; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008875:Middle Aged; D017817:Nasal Lavage Fluid / Q000737:chemistry*; D012221:Rhinitis, Allergic, Perennial / Q000097:blood / Q000378:metabolism*; D012260:Ribonucleases / Q000032:analysis* / Q000502:physiology
D001798:Blood Proteins; D019040:E-Selectin; D047091:Eosinophil Granule Proteins; D007073:Immunoglobulin E; D012260:Ribonucleases