[Changes of plasma nitric oxide and tumor necrosis factor-alpha in lung elastase injury induced inflammatory response of hamster].
OBJECTIVE
To investigate the role of the NO and TNF-alpha in lung elastase injury induced inflammatory response of hamster.


METHODS
Lung elastase injury induced inflammatory hamster model was established. NOS activity in airway epithelial cells and lung monocytes/macrophage, as well as the serum content of NO and TNF-alpha were measured respectively.


RESULTS
The results indicated that iNOS activity in epithelium and monocytes/macrophages were significantly enhanced. In the early period of inflammation the NO and TNF-alpha content in serum increased obviously and maintained in a high level (P < 0.001).


CONCLUSIONS
This Study suggested that both NO and TNF-alpha are important mediators participating in the lung elastase injury-induced inflammatory response. Our data suggested NO might play a regulatory role in the release of TNF-alpha.
Li
X
X
Department of Physiology, Institute of Basic Medical Science, CAMS, PUMC, Beijing 100005, China. Lxyw315@ns.cetin.net.cn
Cai
Y
Y
Cai
Q
Q
Yang
Y
Y
Su
S
S
D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D008297:Male; D009569:Nitric Oxide / Q000097:blood* / Q000502:physiology; D010196:Pancreatic Elastase / Q000633:toxicity*; D011014:Pneumonia / Q000097:blood* / Q000139:chemically induced; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism* / Q000502:physiology
D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D010196:Pancreatic Elastase