title: Degenerative encephalopathy in a coastal mountain kingsnake (Lampropeltis zonata multifasciata) due to adenoviral-like infection.
abstract: In March 2000, an approximately 30-yr-old, male coastal mountain kingsnake (Lampropeltis zonata multifasciata) presented with disequilibrium and unresponsiveness to stimuli that ultimately lead to euthanasia. Histologically, there were foci of gliosis primarily within the caudal cerebrum, brainstem, and cervical spinal cord. Several glial cells and endothelial cells contained magenta, intranuclear inclusion bodies. Electron microscopy of the inclusions revealed paracrystalline arrays of 79-82 nm, viral-like particles. DNA in situ hybridization of sections of formalin-fixed brain using a mixture of two digoxigenin-end-labeled, adenovirus specific, oligonucleotide probes at low and high stringency was positive for adenovirus.
authors.affiliation: Northwest ZooPath, 18210 Waverly Drive, Snohomish, Washington 98296-4815, USA. Zoopath2@aol.com
authors.forename: James T
authors.initials: JT
authors.lastname: Raymond
authors.forename: Marnie
authors.initials: M
authors.lastname: Lamm
authors.forename: Robert
authors.initials: R
authors.lastname: Nordhausen
authors.forename: Ken
authors.initials: K
authors.lastname: Latimer
authors.forename: Michael M
authors.initials: MM
authors.lastname: Garner
mesh_terms: D000256:Adenoviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000648:ultrastructure; D000257:Adenoviridae Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D000818:Animals; D001927:Brain Diseases / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D017812:Colubridae; D004279:DNA, Viral / Q000302:isolation & purification; D037901:Euthanasia, Animal; D017809:Fatal Outcome; D017403:In Situ Hybridization / Q000662:veterinary; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary; D013687:Telencephalon / Q000473:pathology / Q000648:ultrastructure / Q000821:virology
chemical_list: D004279:DNA, Viral