Antiprotozoal activity of the constituents of Teloxys graveolens.
Antiprotozoal activity-guided fractionation of a methanol extract of the aerial parts of Teloxys graveolens led to the isolation of one coumarinic acid derivative, melilotoside, and five flavonoids, pinocembrine, pinostrobin, chrysin, narcissin and rutin. Among them, melilotoside exhibited the most potent activity toward Entamoeba histolytica and Giardia lamblia (IC(50) 12.5 and 16.8 micro g/mL, respectively). Narcissin showed selectivity against E. histolytlica (IC(50) 17.2 micro g/mL). The results support data for the traditional use of T. graveolens in some gastrointestinal diseases.
Calzada
Fernando
F
Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatría, 2 piso, Centro Médico Nacional Siglo XXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores, CP 06725, México, D. F. fercalberl@hotmail.com
Velázquez
Claudia
C
Cedillo-Rivera
Roberto
R
Esquivel
Baldomero
B
D027703:Amaranthaceae; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004748:Entamoeba histolytica / Q000187:drug effects; D004749:Entamoebiasis / Q000188:drug therapy; D016829:Giardia lamblia / Q000187:drug effects; D005873:Giardiasis / Q000188:drug therapy; D020128:Inhibitory Concentration 50; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000981:Antiprotozoal Agents; D010936:Plant Extracts