title: Association of genetic variation of the RIL gene, encoding a PDZ-LIM domain protein and localized in 5q31.1, with low bone mineral density in adult Japanese women.
abstract: Twin and family studies had shown that genetic factors are important determinants of bone mass. Multiple genes might be involved. One candidate gene, the reversion-induced LIM gene ( RIL), is a PDZ and LIM-domain-containing protein and has been localized within the cytokine cluster of chromosome 5 (5q31.1). In a genetic study of 370 adult Japanese women, we investigated the correlation between radial bone mineral density (BMD) and a genetic variation (-3333T-->C) of the 5'-flanking region of RIL gene. A significant association was identified between the RIL variation -3333T-->C and radial BMD ( r=0.15, P=0.003). The variation of the RIL locus may be an important determinant of osteoporosis.
authors.affiliation: Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan.
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Omasu
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Ezura
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Kajita
authors.forename: Ryota
authors.initials: R
authors.lastname: Ishida
authors.forename: Mina
authors.initials: M
authors.lastname: Kodaira
authors.forename: Hideo
authors.initials: H
authors.lastname: Yoshida
authors.forename: Takao
authors.initials: T
authors.lastname: Suzuki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hosoi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inoue
authors.forename: Masataka
authors.initials: M
authors.lastname: Shiraki
authors.forename: Hajime
authors.initials: H
authors.lastname: Orimo
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Emi
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density; D002681:China; D002895:Chromosomes, Human, Pair 5; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007564:Japan; D060588:LIM Domain Proteins; D008875:Middle Aged; D010024:Osteoporosis / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D017434:Protein Structure, Tertiary
chemical_list: D004268:DNA-Binding Proteins; D060588:LIM Domain Proteins; C486247:PDLIM4 protein, human