[Study on the role of interleukin-5 and eosinophil cationic protein and the correlation between them in nasal polyp].
OBJECTIVE
To evaluate the degree of recruitment and activation of eosinophils; to confirm the concentration and expression of IL-5 in nasal polyps; to study the correlation between eosinophilic activation and cytokine such as IL-5.


METHODS
Blood and nasal specimens were collected from 30 patients with nasal polyps and 8 controls with deviation of nasal septum or OSAS. The serum ECP levels in two groups and the IL-5 and ECP in nasal polyp specimens or inferior turbinate mucosa were examined.


RESULTS
Concentration of IL-5 and ECP in nasal polyps tissue homogenates were significantly higher than those in inferior turbinate mucosas (P < 0.05). The same result was showed in serum ECP. The elevated IL-5 levels in polyp homogenates had a significant correlation with serum ECP(r = 0.598, P < 0.05) and polyp tissues ECP(r = 0.451, P < 0.05).


CONCLUSIONS
The concentration of IL-5 increased in the nasal polyp tissues and the degree of expression showed a significant correlation with activated eosinophils.
Wang
Jianling
J
Department of Otolaryngology, Tianjin Medical University General Hospital, Tianjin 300052.
Ma
Ruiqin
R
Yang
Haiyi
H
Zhou
Huifang
H
Liu
Yuzhi
Y
D001798:Blood Proteins / Q000032:analysis / Q000502:physiology*; D047091:Eosinophil Granule Proteins; D005260:Female; D006801:Humans; D015848:Interleukin-5 / Q000032:analysis / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology; D012260:Ribonucleases / Q000032:analysis / Q000502:physiology*
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D015848:Interleukin-5; D012260:Ribonucleases