title: Pathology of the temporomandibular joint of patients with rheumatoid arthritis--case reports of secondary amyloidosis and macrophage populations.
abstract: BACKGROUND
  The pathogenetic features of rheumatoid arthritis of the temporomandibular joint (TMJ) are not well defined. In this paper the histological features of TMJs affected by rheumatoid arthritis, and the detection of secondary amyloidosis and macrophage populations in the TMJs of two patients with progressive rheumatoid arthritis are described.
  
  
  METHODS
  In two patients (64-year-old man and 61-year-old woman) with rheumatoid arthritis total TMJ replacement were performed. The surgical specimens were studied histologically.
  
  
  RESULTS
  It was found that the articular cartilage had been completely replaced by proliferating fibrous tissue. Congo red staining and polarizing microscopy revealed amyloid deposition in the connective tissue of the joint space. Immunohistochemical staining showed CD 68 positive macrophages around the amyloid deposition in the proliferating soft tissue.
  
  
  CONCLUSIONS
  TMJ involvement in rheumatoid arthritis followed the same destructive pathway as in other joints. Amyloid deposition and macrophage populations were detected in two TMJs affected by rheumatoid arthritis.
authors.affiliation: Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University, Graduate School of Medicine and Dentistry, Shikata, Okayama, Japan. ueno@md.okayama-u.ac.jp
authors.forename: Takaaki
authors.initials: T
authors.lastname: Ueno
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Kagawa
authors.forename: Miwa
authors.initials: M
authors.lastname: Kanou
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Ishida
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujii
authors.forename: Joji
authors.initials: J
authors.lastname: Fukunaga
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Mizukawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Sugahara
mesh_terms: D000682:Amyloid / Q000032:analysis; D000686:Amyloidosis / Q000150:complications / Q000473:pathology*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000473:pathology*; D002358:Cartilage, Articular / Q000473:pathology; D002452:Cell Count; D003238:Connective Tissue / Q000473:pathology; D005260:Female; D005355:Fibrosis; D006801:Humans; D008264:Macrophages / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013705:Temporomandibular Joint Disorders / Q000150:complications / Q000473:pathology*
chemical_list: D000682:Amyloid