Antioxidant properties of scopoletin isolated from Sinomonium acutum.
Scopoletin was isolated from Sinomonium acutum and studied using four experimental models designed to assess antioxidant properties. The results indicated that scopoletin scavenged superoxide anion in the xanthine/xanthine oxidase reaction system in a concentration-dependent manner, but did not inhibit xanthine oxidase. Scopoletin may therefore be responsible for the superoxide anion scavenging activity seen in Sinomonium acutum extracts and may be of use in preventing superoxide anion-induced damage in vivo.
Shaw
Chin-Ying
CY
Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan, Republic of China.
Chen
Chen-Hui
CH
Hsu
Chih-Chieh
CC
Chen
Chien-Chih
CC
Tsai
Ying-Chieh
YC
D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001713:Biphenyl Compounds; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006861:Hydrogen Peroxide; D017665:Hydroxyl Radical; D008517:Phytotherapy; D010851:Picrates; D018547:Plant Stems / Q000737:chemistry; D012603:Scopoletin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D032841:Sinomenium / Q000737:chemistry*; D013481:Superoxides
D000975:Antioxidants; D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D010851:Picrates; D013481:Superoxides; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl; D012603:Scopoletin