title: [From clone selection to danger model].
abstract: How is the balance between immune response and immune tolerance dynamically kept in the complicated immune system of human body? To answer this question, many scientists have proposed various models since 1950's. A brief introduction to these models is given in this mini-review, which might reflect the historical process in the development of immunology in the past half century.
authors.affiliation: Department of Clinical Medicine, PUMC, Beijing 100730, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Huang
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Zhu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017635:Clonal Anergy; D002999:Clone Cells; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D018448:Models, Immunological