Anti-ulcerogenic activity of some plants used as folk remedy in Turkey.
Five herbal remedies used as gastroprotective crude drugs in Turkey were assessed for anti-ulcerogenic activity using the EtOH-induced ulcerogenesis model in rat. The crude drugs investigated comprises fruits of Elaeagnus angustifolia L. (Elaeagnaceae), fresh fruits of Hibiscus esculentus L. (Malvaceae), fresh roots of Papaver rhoeas L. (Papaveraceae), leaves of Phlomis grandiflora H.S. Thomson (Lamiaceae) and fresh fruits of Rosa canina L. (Rosaceae). Extracts were prepared according to the traditional indications of use. Under our experimental conditions, all extracts exhibited statistically significant gastroprotective effect with better results for Phlomis grandiflora and Rosa canina (100%). At the concentration under study, both crude drugs were more effective than the reference compound misoprostol at 0.4 mg/kg. Even the weakest anti-ulcerogenic effect observed for Papaver rhoeas roots was found statistically potent (95.6%). Histopathological studies confirmed the results of the in vivo test.
Gürbüz
Ilhan
I
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, 6330 Ankara, Turkey.
Ustün
Osman
O
Yesilada
Erdem
E
Sezik
Ekrem
E
Kutsal
Osman
O
D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D031263:Elaeagnaceae / Q000737:chemistry / Q000502:physiology; D000431:Ethanol / Q000633:toxicity; D005260:Female; D005638:Fruit / Q000737:chemistry; D008297:Male; D019660:Malvaceae / Q000737:chemistry / Q000502:physiology; D008519:Medicine, Traditional; D028101:Papaveraceae / Q000737:chemistry / Q000502:physiology; D010437:Peptic Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D031345:Phlomis / Q000737:chemistry / Q000502:physiology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D027824:Rosaceae / Q000737:chemistry / Q000502:physiology; D014421:Turkey
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D000431:Ethanol