Olanzapine pharmacokinetics are similar in Chinese and Caucasian subjects.
OBJECTIVE
To compare the pharmacokinetic profiles and dose proportionality of olanzapine in Chinese and Caucasian subjects.


METHODS
Randomized, three-period study with 12 Chinese and 12 Caucasian, healthy, male subjects administered 2.5, 5 and 10 mg olanzapine. Noncompartmental pharmacokinetic parameters were derived.


RESULTS
No statistically significant racial differences in the weight-normalized pharmacokinetic parameters were observed except for Vz/Fnorm, which was 17% lower at the 5- and 10-mg dose in the Chinese group (95% confidence interval 8.49, 10.1 and 8.05, 9.73, respectively), compared with the Caucasian group (9.53, 12.8 and 9.39, 12.0, respectively). Olanzapine's pharmacokinetics were linear and dose proportional in both racial groups.


CONCLUSIONS
The pharmacokinetics of olanzapine are similar in both Chinese and Caucasian racial groups.
Sathirakul
Korbtham
K
Lilly-NUS Centre for Clinical Pharmacology, National University of Singapore, Singapore.
Chan
Clark
C
Teng
Leyan
L
Bergstrom
Richard F
RF
Yeo
Kwee Poo
KP
Wise
Stephen D
SD
D000284:Administration, Oral; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D044466:Asian People; D001569:Benzodiazepines; D006801:Humans; D008297:Male; D000077152:Olanzapine; D010890:Pirenzepine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D044465:White People
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine