Protective effects of ACTH (4-9) in degeneration of hippocampal nerve cells caused by dexamethasone: ultrastructural studies.
The purpose of this research was an assessment of protective action of ACTH (4-9) in dexamethasone-induced neurodegeneneration on the base of ultrastructural examinations of hippocampal neurons in the CA3 region. The experiments were carried out on adult Albino Swiss mouse males. The animals were divided into three groups: control group, experimental group 1-dexamethasone 8 mg/kg/24 h for 28 days, experimental group 2-dexamethasone and ACTH (4-9) 50 micrograms/kg twice a week. Results of our investigations show that ACTH (4-9) prevents neurotoxic influence of dexamethasone and its protective action is connected with the ability to inhibit degenerative processes in neurons having a character of apoptosis.
Sekita-Krzak
Joanna
J
Department of Histology and Embryology with Lab of Experimental Cytology, Department of Clinical Pharmacology, Medical University of Lublin.
Czerny
Krystyna
K
Zebrowska-Łupina
Iwona
I
Stepniewska
Maria
M
Visconti
Józef
J
Wieczorski
Marcin
M
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D003907:Dexamethasone / Q000008:administration & dosage* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006624:Hippocampus / Q000187:drug effects / Q000648:ultrastructure; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009410:Nerve Degeneration / Q000139:chemically induced / Q000473:pathology*; D018696:Neuroprotective Agents / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000187:drug effects* / Q000648:ultrastructure*
D018696:Neuroprotective Agents; D010446:Peptide Fragments; C028024:ACTH (4-9); D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone