Does endothelial nitric oxide synthase gene variation play a role in the occurrence of hypertension in pregnancy?
OBJECTIVE
Nitric oxide is suggested to play a role in the development of preeclampsia.


METHODS
We studied 61 patients with gestational hypertension (GH), 77 with GH and significant proteinuria (urine protein excretion > or = 300 mg/24 h), 82 with essential hypertension (EH) and 188 normotensive women with at least one normal pregnancy.


METHODS
A polymorphism within the constitutive endothelial nitric oxide synthase (ecNOS) gene in various types of hypertension in pregnancy was explored.


RESULTS
Allelic and genotypic frequencies did not differ between controls and case groups. A significant difference was observed between the frequency of the rare allele in GH patients and that in EH group (chi2: 4.47, P <.04). This difference approximated the significance when GH subjects with or without proteinuria were grouped (chi2 square: 3.33; P =.068). Cigarette smoking or gravidity did not interact with the ecNOS polymorphism in identifying different types of hypertension in this setting.


CONCLUSIONS
Our findings argue against an association between ecNOS polymorphism and preeclampsia and support the hypothesis for a different pathogenesis of GH in respect to EH.
Grandone
Elvira
E
Atherosclerosis and Thrombosis Unit, Division of Obstetrics and Gynaecology, I.R.C.C.S., "Casa Sollievo della Sofferenza", S. Giovanni Rotondo (FG), Italy. ate.tro@operapadrepio.it
Colaizzo
Donatella
D
Martinelli
Pasquale
P
Pavone
Giuseppe
G
Errico
Massimo
M
Vecchione
Gennaro
G
Margaglione
Maurizio
M
D000328:Adult; D000483:Alleles; D000704:Analysis of Variance; D001483:Base Sequence; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D015994:Incidence; D016015:Logistic Models; D008969:Molecular Sequence Data; D019001:Nitric Oxide Synthase / Q000235:genetics*; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis* / Q000453:epidemiology; D011256:Pregnancy Outcome; D018570:Risk Assessment
D019001:Nitric Oxide Synthase