Synthesis of PNA using a Fmoc/Boc protecting group strategy.
Syntheses of PNA monomers whose nucleobases are protected with Boc group are described. To overcome the solubility problem of carboxymethyl-guanine derivative, we introduced 2-trimethylsilylethyl group at O6 as a second protecting group.
Sugiyama
Toru
T
Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan.
Kittaka
Atsushi
A
Takemoto
Yohei
Y
Takayama
Hiroaki
H
Kuroda
Reiko
R
D005449:Fluorenes / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis*
D005449:Fluorenes; D020135:Peptide Nucleic Acids