Silylative carbocyclization of allenyl-carbonyl units with Et3SiH catalyzed by rhodium: cis-stereoselective synthesis of homoallylic cycloalkanols.
[reaction: see text] A new procedure for the synthesis of cis-2-triethylsilylvinyl-cyclopentanols and -cyclohexanols from allenyl-aldehydes and -ketones with Et(3)SiH through rhodium-catalyzed silylative carbocyclization is described. The use of Rh(acac)(CO)(2) (1 mol %) to promote the reaction results in a mild and convenient protocol for the three-component assembly.
Kang
Suk-Ku
SK
Department of Chemistry and Laboratory for Metal-Catalyzed Reactions (NRL), Sungkyunkwan University, Suwon 440-746, Korea.
Hong
Young-Taek
YT
Lee
Joon-Hwan
JH
Kim
Won-Yeol
WY
Lee
Inhee
I
Yu
Chan-Mo
CM