[The association between glucocorticoid receptor gene G1666T polymorphism and cerebral infarction in Chinese].
OBJECTIVE
To ascertain whether the human glucocorticoid receptor (GR) gene polymorphism is associated with cerebral infarction (CI) and essential hypertension (EH) in Chinese.


METHODS
This is a case-control study of Chinese DNA samples abstracted from 163 subjects. The samples were analysed by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to determine the intron 4 variant of human GR gene.


RESULTS
By analysis of the samples from both sexes as a whole, no association was observed between the EH+CI group and control group, and between the CI group and control group. However, by analysis of the samples from the females, weak association was observed between the EH+CI group and control group, and between the CI group and control group; the frequency of allele G was 0.64 for the EH+CI group, 0.69 for CI group and 0.46 for control group.


CONCLUSIONS
The G allele may be a predisposing gene marker, GR gene intron 4 polymorphism contributes to the development of CI in females.
Chi
Lan-qin
LQ
Department of Neurology, Laiyang Central Hospital, Yantai, Shandong, 265200 PR China. LINZHIXD@public.ytptt.sd.cn
Zhang
Chen
C
Luo
Bing
B
Sun
Hao-yun
HY
D044466:Asian People / Q000235:genetics; D002544:Cerebral Infarction / Q000208:ethnology / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011965:Receptors, Glucocorticoid / Q000235:genetics*
D011965:Receptors, Glucocorticoid