title: The interaction of 2-phenylbenzimidazole compounds with DNA: the influence of terminal substituents.
abstract: We have studied the influence of terminal substituents, amidinium group and N-methylpiperazine ring, of 2-phenylbenzimidazole compounds (1-6; Figure 1) on their DNA-binding modes. Experimental results reveal that 1-3 are accepted in intercalation pockets owing to structural flexibility of the N-methylpiperazine ring, while 4-6 bind to the groove of DNA because of steric hindrance between the amidinium group and the DNA phosphate-sugar backbone.
authors.affiliation: Department of Chemistry, Faculty of Science, Yamaguchi University, Yamaguchi 753-8512, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kubota
authors.forename: Seiji
authors.initials: S
authors.lastname: Tani
authors.forename: Junichi
authors.initials: J
authors.lastname: Nakamura
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry*; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001562:Benzimidazoles; D004247:DNA; C117755:2-phenylbenzimidazole