Linkage and association between serotonin 2A receptor gene polymorphisms and bipolar I disorder.
Several inconsistent associations between bipolar I disorder (BD1) and polymorphisms of the genes encoding the serotonin 2A receptor (HTR2A) have been published. We conducted the Transmission Disequilibrium Test (TDT) and case-control comparisons involving nine single nucleotide polymorphisms at the serotonin 2A receptor gene (four SNPs of HTR2A exons and five flanking SNPs). Comparison of BD1 cases (n = 93) with a group of unrelated population based controls (n = 92) revealed associations with SNPs on exons 2 and 3 (516C/T and 1354C/T, respectively), consistent with haplotype-based differences. Analysis of the cases and their available parents using the TDT suggested significant linkage and associations with 1354C/T, as well as haplotypes bearing this SNP. Our results support an etiological role for HTR2A in BD1. In view of the relatively small sample, replicate studies using large samples are needed.
Ranade
Swati S
SS
Departments of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
Mansour
Hader
H
Wood
Joel
J
Chowdari
Kodavali V
KV
Brar
Laurie K
LK
Kupfer
David J
DJ
Nimgaonkar
Vishwajit L
VL
D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005312:Fetal Blood; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin