Effects of preweaning doxazosin treatment on adult pressure in the spontaneously hypertensive rat.
1. The neonatal/preweaning period appears to represent a critical period of involvement of the sympathetic nervous system in the development of hypertension in spontaneously hypertensive rats (SHR). 2. We tested whether alpha1-adrenoceptor-mediated effects during the preweaning period are involved in the development of hypertension in the adult SHR. 3. Male SHR were treated with the alpha1-adrenoceptor antagonist doxazosin (10 mg/kg per day, s.c.) from postnatal day 1 to 21 inclusive. Direct conscious blood pressure and heart rate were measured via the caudal artery at 12 weeks of age. 4. Preweaning treatment with doxazosin had no significant effect on mean arterial blood pressure or heart rate in male SHR at 12 weeks of age. 5. These findings do not support the involvement of alpha1-adrenoceptor-mediated effects during the preweaning period in the development of hypertension in adult SHR.
Boesen
Erika I
EI
Department of Physiology Monash University, Melbourne, Victoria, Australia. Erika.Boesen@med.monash.edu.au
Lewis
Tamara V
TV
Kett
Michelle M
MM
Anderson
Warwick P
WP
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D000833:Animals, Suckling; D001794:Blood Pressure / Q000187:drug effects*; D006332:Cardiomegaly / Q000503:physiopathology / Q000517:prevention & control; D017292:Doxazosin / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D011247:Pregnancy; D051381:Rats; D011918:Rats, Inbred SHR; D018340:Receptors, Adrenergic, alpha-1 / Q000008:administration & dosage
D000317:Adrenergic alpha-Antagonists; D018340:Receptors, Adrenergic, alpha-1; D017292:Doxazosin