title: [Gutteral pouch tympany in German warmblood foals: influence of sex, inbreeding and blood proportions of founding breeds as well as estimation of heritability].
abstract: The objective of the present study was to analyse the importance of the influences of sex, inbreeding coefficient, proportion of genes of the original breeds and the additive genetic contribution to the occurrence of guttural pouch tympany in foals belonging to German Warmblood breeds. Foals affected by guttural pouch tympany were ascertained in the Clinic of Horses, School of Veterinary Medicine Hannover. This data set comprised 22 German Warmblood foals with guttural pouch tympany, which were patients of the Clinic for Horses between 1994 and 2001. Information on the pedigrees and all available relatives of these patients allowed us to group the affected foals into five families with a total of 289 animals. Female foals were significantly more often affected by guttural pouch tympany. The difference was 16.6% in favour of female foals. The size of the inbreeding coefficient was not important for the occurrence of guttural pouch tympany. The proportion of the genes of the breeds Arabian, Thoroughbred and Trakehner were not significantly different from a randomly selected sample of 10% of foals born in the same birth years and the same region. The heritability estimates for the frequency of guttural pouch tympany using a threshold model was 0.81 +/- 0.16. This is the first report that could show a genetic component responsible for guttural pouch tympany in horses.
authors.affiliation: Institut für Tierzucht und Vererbungsforschung, Hannover.
authors.forename: Ingild
authors.initials: I
authors.lastname: Blazyczek
authors.forename: Henning
authors.initials: H
authors.lastname: Hamann
authors.forename: Bernhard
authors.initials: B
authors.lastname: Ohnesorge
authors.forename: Eckehard
authors.initials: E
authors.lastname: Deegen
authors.forename: Ottmar
authors.initials: O
authors.lastname: Distl
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D005260:Female; D006734:Horse Diseases / Q000453:epidemiology / Q000235:genetics*; D006736:Horses / Q000235:genetics*; D007178:Inbreeding; D008297:Male; D008957:Models, Genetic; D010608:Pharyngeal Diseases / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D010614:Pharynx / Q000473:pathology; D015995:Prevalence; D012737:Sex Factors