title: Fasting insulin concentration is highly correlated with quantitative insulin sensitivity check index.
abstract: Given that the "gold standard" method for evaluating insulin sensitivity in vivo (hyperinsulinemic euglycemic glucose clamp technique) cannot be routinely applied because of technical reasons, simple methods and indexes were developed and are currently available to assess insulin sensitivity in vivo. Quantitative insulin sensitivity check index (QUICKI) has recently been described and is able to accurately estimate insulin sensitivity from a fasting blood sample. We demonstrated that fasting insulin levels strongly inversely correlated with QUICKI in three different groups: 215 healthy nondiabetic nonobese subjects, 62 nondiabetic obese subjects, and 44 patients with glucose intolerance or type 2 diabetes mellitus. Fasting insulin measurement is a simple way of assessing insulin sensitivity in obese and nonobese humans, with or without glucose intolerance or type 2 diabetes mellitus.
authors.affiliation: Department of Endocrinology, Fleury Medical Diagnostic Center, São Paulo, Brazil. omar.hauache@fleury.com.br
authors.forename: Omar M
authors.initials: OM
authors.lastname: Hauache
authors.forename: José G H
authors.initials: JG
authors.lastname: Vieira
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis; D005215:Fasting / Q000097:blood*; D005260:Female; D015309:Glucose Clamp Technique / Q000379:methods; D018149:Glucose Intolerance / Q000097:blood* / Q000175:diagnosis; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin