title: Pyothorax-associated angiosarcoma of the pleura with metastasis to the brain.
abstract: Pleural angiosarcoma is an extremely rare, highly malignant neoplasm. Chronic tuberculous pyothorax is one of the etiological factors associated with the development of pleural angiosarcoma. This report details a case of pleural angiosarcoma in a 70-year-old woman with a history of tuberculous pyothorax. Coagulated blood surrounded by thickened pleura in the right thorax and hematoma-like multiple metastases in the brain were noted on autopsy. The pleural lesion was presumed to be the primary site. Microscopic examination revealed rudimentary channels lined by plump neoplastic cells in the coagulated blood of the pleura and the brain. These neoplastic cells stained positive for endothelial markers. A literature review of English language journals revealed this to be the first patient described in detail who developed cerebral metastasis secondary to pleural angiosarcoma.
authors.affiliation: Second Department of Pathology, Kinki University School of Medicine, Osaka-Sayama, Japan. kimura-mu@med.kindai.ac.jp
authors.forename: Masatomo
authors.initials: M
authors.lastname: Kimura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ito
authors.forename: Tomoko
authors.initials: T
authors.lastname: Furuta
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Tsumoto
authors.forename: Seiji
authors.initials: S
authors.lastname: Hayashi
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D016724:Empyema, Pleural / Q000150:complications* / Q000209:etiology; D004654:Empyema, Tuberculous / Q000150:complications; D017809:Fatal Outcome; D005260:Female; D006394:Hemangiosarcoma / Q000209:etiology* / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology*; D014057:Tomography, X-Ray Computed