Aplastic anaemia: a review.
Aplastic anaemia is featured by bone marrow hypocellularity and peripheral pancytopenia and is a potentially fatal disease. In recent years, insight in it pathogenesis has increased. It appears that activated autoreactive T lymphocytes induce apoptosis of haematopoietic stem cells resulting in a hypocellular bone marrow. Nowadays, it can be treated by stem cell transplantation or immunosuppressive therapy. This review focuses on the pathophysiology and treatment of aplastic anaemia.
Sleijfer
S
S
Department of Internal Medicine, Erasmus Medical Centre, University Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
Lugtenburg
P J
PJ
D000741:Anemia, Aplastic / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans