[Evaluation on monkeys of reactogenicity and effectiveness of the complex immunoglobulin preparation formulation].
Experiments on 75 monkeys, 20--healthy and 75--with diarrhea, showed that ready medicinal forms of the complex immunoglobulin preparation in tablets, capsules or in a dried form (vials) were safe, well tolerated, clinically and bacteriologically effective. When used simultaneously with antiparasitic treatment, this preparation, irrespective of the kind of its ready medicinal form, showed high curative effect (80-90%). The diarrhea ceasing was accompanied by the gradual normalization of intestinal microbiocenosis (an increased concentrations of Escherichia coli and Bifidobacterium, a decreased amount of opportunistic bacteria). The complex method of the treatment of diarrhea in monkeys (antibiotics, trichopol, phage and probiotics) made it possible to achieve curative effect only in 60% of cases, which required the additional course of treatment, namely the use of rehydration therapy.
Lapin
B A
BA
Gabrichevsky Research Institute of Epidemiology and Microbiology, Moscow, Russia.
Aleshkin
V A
VA
Davydkin
V Iu
VIu
Vorob'ev
A A
AA
Dzhikidze
E K
EK
Afanas'ev
S S
SS
Stasilevich
Z K
ZK
Kebu
T I
TI
Davydkin
I Iu
IIu
Borisova
I V
IV
Gvozdik
T E
TE
Kalashnikova
V A
VA
Gavrin
A G
AG
Zorik
A V
AV
Novikova
L I
LI
D000818:Animals; D000907:Antibodies, Bacterial / Q000494:pharmacology / Q000627:therapeutic use; D000914:Antibodies, Viral / Q000494:pharmacology / Q000627:therapeutic use; D003967:Diarrhea / Q000188:drug therapy*; D004339:Drug Compounding; D004353:Drug Evaluation, Preclinical; D004361:Drug Tolerance; D000882:Haplorhini; D007136:Immunoglobulins / Q000494:pharmacology / Q000627:therapeutic use*
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D007136:Immunoglobulins