title: Identification of the hypervirulent lineages of Neisseria meningitidis, the ST-8 and ST-11 complexes, by using monoclonal antibodies specific to NmeDI.
abstract: Most cases of serogroup C meningococcal disease are caused by the clonal lineages ST-8 and ST-11. The gene encoding the putative restriction-modification system NmeDI is specific to these lineages. We report here a monoclonal antibody directed against the NmeDI endonuclease as a tool for their rapid and spe-cific identification.
authors.affiliation: Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
authors.forename: Heike
authors.initials: H
authors.lastname: Claus
authors.forename: Hanne
authors.initials: H
authors.lastname: Weinand
authors.forename: Matthias
authors.initials: M
authors.lastname: Frosch
authors.forename: Ulrich
authors.initials: U
authors.lastname: Vogel
mesh_terms: D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D015373:Bacterial Typing Techniques; D002353:Carrier State / Q000382:microbiology; D006801:Humans; D009345:Neisseria meningitidis / Q000145:classification / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D015183:Restriction Mapping; D014774:Virulence
chemical_list: D000911:Antibodies, Monoclonal