Discovery of a novel route to 2'-deoxy and 2'-functional pyrimidine nucleosides via 3',5'-O-sulfinyl xylo-nucleosides.
We synthesized 2,2'-anhydro-pyrimidine nucleosides through a novel and efficient rearrangement with 3',5'-O-sulfinyl xylo nucleosides which were prepared from an inexpensive starting material, D-xylose. A variety of 2'-deoxy and 2'-functional pyrimidine nucleosides can be prepared from 2,2'-anhydro-pyrimidine nucleosides.
Takatsuki
Ken-ichi
K
Ichikawa Research Institute, Kobayashi Perfumery CO., LTD., 4-12-1 Ohwada, Ichikawa-City 272-0025, Japan.
Kohmoto
Shigeo
S
Kishikawa
Keiki
K
Yamashita
Haruhiro
H
Yamamoto
Makoto
M
D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D011741:Pyrimidine Nucleosides