title: Components of the smooth pursuit function in deficit and nondeficit schizophrenia.
abstract: The diagnosis of schizophrenia likely encompasses a heterogeneous group of disorders, complicating the search for its causes. Studies of deficit schizophrenia represent an attempt to reduce this heterogeneity by identifying biologically distinct subgroups. Supplementing clinical phenotypes with biological markers of risk (e.g., eye-tracking and sensory-gating deficits) have also been used to reduce disease heterogeneity. In this study, we examined smooth pursuit eye movements in healthy controls (n = 37), and deficit (n = 18) and nondeficit (n = 32) patients with schizophrenia to determine what aspects of abnormal smooth pursuit are associated with the two patient groups, and which, if any, specifically mark the deficit phenotype. A small sample of relatives of deficit (n = 12) and nondeficit (n = 35) patients was also examined. Positive symptoms were equally present in deficit and nondeficit patients. Subtle, psychotic-like positive traits were also equally present in the relatives of both deficit and nondeficit probands, whereas negative symptoms were significantly more prevalent among the relatives of deficit probands. Deficits in predictive pursuit were present in both patient groups and both groups of relatives. Deficit patients showed significantly lower initiation acceleration. A similar pattern of results was seen in our pilot sample of relatives of deficit patients. These findings suggest that predictive smooth pursuit abnormality is associated with positive symptoms in schizophrenia, and that initiation abnormalities may be associated with the deficit syndrome.
authors.affiliation: Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P.O. Box 21247, Baltimore, MD 21228, USA. ehong@mprc.umaryland.edu
authors.forename: L Elliot
authors.initials: LE
authors.lastname: Hong
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Avila
authors.forename: Helene
authors.initials: H
authors.lastname: Adami
authors.forename: Amie
authors.initials: A
authors.lastname: Elliot
authors.forename: Gunvant K
authors.initials: GK
authors.lastname: Thaker
mesh_terms: D000328:Adult; D015415:Biomarkers; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000150:complications; D008297:Male; D019964:Mood Disorders / Q000150:complications; D009042:Motivation; D010641:Phenotype; D010865:Pilot Projects; D011237:Predictive Value of Tests; D012307:Risk Factors; D012438:Saccades / Q000502:physiology*; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D012720:Severity of Illness Index; D012919:Social Behavior
chemical_list: D015415:Biomarkers