title: [Transition from intravenous to subcutaneous prostacyclin in pulmonary hypertension].
abstract: Treatment of arterial pulmonary hypertension with epoprostenol (intravenous prostacyclin) improves survival and quality of life, but the need for an implanted central venous catheter is associated with frequent complications, that often (as in the case of infection or dislodgment) are serious and require catheter replacement. Treprostinil is a prostacyclin analogue suitable for continuous subcutaneous administration. We report the successful transition from intravenous epoprostenol to subcutaneuos treprostinil in four patients with severe pulmonary hypertension who suffered from serious complications associated with the epoprostenol infusion system.
authors.affiliation: Servicio de Cardiología. Unidad de Hipertensión Pulmonar, Insuficiencia Cardíaca y Trasplante Cardíaco. Hospital Universitario 12 de Octubre. Madrid. España. med022585@saludalia.com
authors.forename: Pilar
authors.initials: P
authors.lastname: Escribano Subías
authors.forename: Luis
authors.initials: L
authors.lastname: Cea-Calvo
authors.forename: Rocío
authors.initials: R
authors.lastname: Tello de Menesses
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Gómez Sánchez
authors.forename: Juan F
authors.initials: JF
authors.lastname: Delgado Jiménez
authors.forename: Carlos
authors.initials: C
authors.lastname: Sáenz de la Calzada
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control; D002405:Catheterization, Central Venous / Q000009:adverse effects; D011464:Epoprostenol / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D007262:Infusions, Intravenous / Q000009:adverse effects; D007279:Injections, Subcutaneous; D008875:Middle Aged
chemical_list: D000959:Antihypertensive Agents; D011464:Epoprostenol; C427248:treprostinil