title: THoR: a tool for domain discovery and curation of multiple alignments.
abstract: We describe a tool, THoR, that automatically creates and curates multiple sequence alignments representing protein domains. This exploits both PSI-BLAST and HMMER algorithms and provides an accurate and comprehensive alignment for any domain family. The entire process is designed for use via a web-browser, with simple links and cross-references to relevant information, to assist the assessment of biological significance. THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases.
authors.affiliation: MRC Functional Genetics Unit, University of Oxford, Department of Human Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK. nicholas.dickens@anat.ox.ac.uk
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Dickens
authors.forename: Chris P
authors.initials: CP
authors.lastname: Ponting
mesh_terms: D000465:Algorithms; D000818:Animals; D019985:Benchmarking / Q000379:methods; D030562:Databases, Protein; D029941:Fish Proteins / Q000737:chemistry*; D016678:Genome; D020407:Internet / Q000639:trends; D010455:Peptides / Q000737:chemistry*; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment / Q000379:methods* / Q000639:trends; D017386:Sequence Homology, Amino Acid; D012984:Software / Q000639:trends*; D023721:Tetraodontiformes
chemical_list: D029941:Fish Proteins; D010455:Peptides