title: Methamphetamine induces oligodendroglial cell death in vitro.
abstract: We investigated whether the psychostimulant methamphetamine (METH) has a cytotoxic effect on oligodendrocytes and which cell-death pathways are involved in the cytotoxic process. METH caused concentration- and time-dependent cytotoxicity in rat oligodendrocyte cultures. METH induced apoptotic cell death and mRNA expression of pro-apoptotic proteins (bax and DP5), but not anti-apoptotic proteins (bcl-2 and bcl-XL). These results suggest that METH induces cytotoxicity in rat oligodendrocytes via the differential regulation of the expression of genes involved in the apoptotic process.
authors.affiliation: Department of Physiology, Dokuz Eylul University, Inciralti, 35340, Izmir, Turkey. kkursadgenc@hotmail.com
authors.forename: Kursad
authors.initials: K
authors.lastname: Genc
authors.forename: Sermin
authors.initials: S
authors.lastname: Genc
authors.forename: Sefa
authors.initials: S
authors.lastname: Kizildag
authors.forename: Ulker
authors.initials: U
authors.lastname: Sonmez
authors.forename: Osman
authors.initials: O
authors.lastname: Yilmaz
authors.forename: Kazim
authors.initials: K
authors.lastname: Tugyan
authors.forename: Bekir
authors.initials: B
authors.lastname: Ergur
authors.forename: Atac
authors.initials: A
authors.lastname: Sonmez
authors.forename: Zisan
authors.initials: Z
authors.lastname: Buldan
mesh_terms: D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D003603:Cytotoxins / Q000494:pharmacology*; D008694:Methamphetamine / Q000494:pharmacology*; D009479:Neuropeptides / Q000235:genetics; D009836:Oligodendroglia / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D051028:bcl-2-Associated X Protein; D051020:bcl-X Protein
chemical_list: D051017:Apoptosis Regulatory Proteins; C494828:Bax protein, rat; C494813:Bcl2l1 protein, rat; D003603:Cytotoxins; C484585:Hrk protein, rat; D009479:Neuropeptides; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D051028:bcl-2-Associated X Protein; D051020:bcl-X Protein; D008694:Methamphetamine