title: Activity of chemotherapy with carboplatin plus paclitaxel in a recurrent mesonephric adenocarcinoma of the uterine corpus.
abstract: BACKGROUND
  Malignant lesions derived from mesonephric (Wolffian) remnants are uncommon. The course of these tumors is usually indolent, and the recurrence has only been documented in nine cases. Because of the small number of cases, no current recommendations exist regarding treatment, and little is known about the response to chemotherapeutic agents.
  
  
  METHODS
  A 33-year-old woman was diagnosed with a mesonephric adenocarcinoma arising in the uterine corpus. Ten months after initial surgery and radiotherapy she presented with local and pulmonary relapse. Salvage chemotherapy with carboplatin plus paclitaxel was administered with a good response.
  
  
  CONCLUSIONS
  Mesonephric adenocarcinomas are uncommon neoplasms. Their treatment remains elusive. We report a case of a recurrent uterine mesonephric adenocarcinoma that presented a good response to therapy with carboplatin plus paclitaxel. A review of the previous literature is also presented.
authors.affiliation: Department of Medical Oncology, Institute of Oncology and Haematology, University of Barcelona, Hospital Clinic, Barcelona, Spain.
authors.forename: Clara
authors.initials: C
authors.lastname: Montagut
authors.forename: Maribel
authors.initials: M
authors.lastname: Mármol
authors.forename: Victoria
authors.initials: V
authors.lastname: Rey
authors.forename: Jaume
authors.initials: J
authors.lastname: Ordi
authors.forename: Jaume
authors.initials: J
authors.lastname: Pahissa
authors.forename: Angeles
authors.initials: A
authors.lastname: Rovirosa
authors.forename: Pedro
authors.initials: P
authors.lastname: Gascón
authors.forename: Begoña
authors.initials: B
authors.lastname: Mellado
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008649:Mesonephroma / Q000188:drug therapy*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage; D014594:Uterine Neoplasms / Q000188:drug therapy*
chemical_list: D016190:Carboplatin; D017239:Paclitaxel