title: [Neoadjuvant radiochemotherapy treatment in locally advanced rectal adenocarcinoma].
abstract: A prospective phase II study was conducted to evacuate toxicity and results of preoperative radiochemotherapy in locoregionally advanced rectal cancer (LARC). A total of 33 patients entered the study and received 45 Gy to the pelvis plus a supplemental boost of 5.4-9 Gy concurrently with 5 FU c.i. at a dose of 225-275 mg/m2. Thirty patients were operated after 5-7 weeks (20 anterior resection and 10 abdominoperineal excision). In 14 patients (47%) a downstaging was observed, 5 patients experienced a complete clearance of the primary tumor. After a median of 14 months (range, 5-27), 23 patients, are alive and well. And 8 patients experienced a disease progression (4 local-regional and 4 distant). Our results provide further evidence of the utility and effectiveness of preoperative radiochemotherapy in LARC.
authors.affiliation: Divisione di Radioterapia Oncologica, Ospedale Oncologico Regionale A Businco, Cagliari.
authors.forename: B
authors.initials: B
authors.lastname: Carau
authors.forename: P
authors.initials: P
authors.lastname: Orrù
authors.forename: S
authors.initials: S
authors.lastname: Orrù
authors.forename: M
authors.initials: M
authors.lastname: Dessì
authors.forename: M
authors.initials: M
authors.lastname: Nagliati
authors.forename: G
authors.initials: G
authors.lastname: Lay
authors.forename: V
authors.initials: V
authors.lastname: Maxia
authors.forename: G
authors.initials: G
authors.lastname: Casula
authors.forename: M
authors.initials: M
authors.lastname: Amichetti
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D017785:Photons / Q000627:therapeutic use; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D011882:Radiotherapy, High-Energy; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D012074:Remission Induction; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil