title: [Antroduodenal motility and pH changes after partial gastrectomy including the pacemaker region of the dog's stomach].
abstract: BACKGROUND
  Functional alterations of antroduodenal motility are not well defined at present. The gastric pacemaker is located at the greater curvature, next to the fundus.
  
  
  OBJECTIVE
  The aim was to evaluate the influence of the gastric pacemaker on the gastroduodenal motility in dogs.
  
  
  METHODS
  The study was designed in three steps and performed with 20 dogs: first, construction of a cervical esophagostomy to measure the antroduodenal motility and gastric pH-metry as validation step. The manometry was performed by means of a six point electronic manometry probe and both manometry and pH-metry were recorded during 4 hours. Second, the stomach's pacemaker region and gastric reservoir were resected by videolaparoscopy. Third, the antroduodenal motility and gastric pH-metry were measured again.
  
  
  RESULTS
  In the validation step, there was established a typical dogs' antroduodenal motility pattern, with a three-shaped interdigestive motility complex (IMC) (phases 1 to 3); the gastric pH-metry showed a baseline at pH 1,15. After partial gastric resection, overall there was an increase in contractions' frequency, an increase in phase 2 and a decrease in phase 3 participation on the IMC's. Regarding the gastric pH measurements, there was an increase in pH intervals 0-1 and 1-2 and a decrease in pH intervals 6-7; overall, there was a decrease in the stomach's pH and a decrease in the prandial time.
  
  
  CONCLUSIONS
  The resection of the stomach's pacemaker region and gastric reservoir correlated with alterations in antroduodenal motility, maintaining however the typical IMC pattern.
authors.affiliation: Programa de Pós-graduação em Clínica Cirúrgica da Universidade Federal do Paraná em cooperação com o Instituto de Pesquisas Médicas da Faculdade Evangélica de medicina do Paraná e a Clínica Cirúrgica da Universidade de Wûrzburg - Almanha, Brasil.
authors.forename: Paulo Afonso Nunes
authors.initials: PA
authors.lastname: Nassif
authors.forename: Karl-Hermann
authors.initials: KH
authors.lastname: Fuchs
authors.forename: Johannes
authors.initials: J
authors.lastname: Heimbucher
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Malafaia
authors.forename: Nicolau Gregori
authors.initials: NG
authors.lastname: Czeczko
authors.forename: Jurandir Marcondes
authors.initials: JM
authors.lastname: Ribas Filho
authors.forename: Arnulf
authors.initials: A
authors.lastname: Thiede
authors.forename: Ulrich Andreas
authors.initials: UA
authors.lastname: Dietz
mesh_terms: D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000502:physiology*; D005743:Gastrectomy / Q000379:methods*; D005745:Gastric Acidity Determination; D005769:Gastrointestinal Motility; D006863:Hydrogen-Ion Concentration; D008365:Manometry; D016065:Myoelectric Complex, Migrating; D010138:Pacemaker, Artificial; D011184:Postoperative Period