title: [Human hepatitis B virus infection of tree shrews and Macaca assamensis in vivo].
abstract: OBJECTIVE
  To examine sensitivity of the tree shrews and Macaca assamensis to human hepatitis B virus (HHBV) by serologic methods.
  
  
  METHODS
  Totally 233 tree shrews and 28 Macaca assamensis were inoculated with human sera containing HBV. After inoculation, the sera were collected weekly from them and HBV markers were detected with HBV ditecting ELISA kits.
  
  
  RESULTS
  Ninety percent of the tree shrews developed acute infection, among them, 44.4 % persisted for over one year, 33.3% of them developed chronic infection persisted for 2 years and one month; the persistence of HBV in Macaca assamensis was much shorter.
  
  
  CONCLUSIONS
  These data clearly indicated that tree shrew may be used as an animal model for study of chronic HBV infection, whereas, Macaca assamensis, showed only a transient sensitivity to HHBV.
authors.affiliation: Guangxi Anti-Epidemic and Health Center, Nanning, China.
authors.forename: Shu-sheng
authors.initials: SS
authors.lastname: Wang
authors.forename: Jian-jia
authors.initials: JJ
authors.lastname: Su
authors.forename: Hua-yuan
authors.initials: HY
authors.lastname: Zhang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: You-chun
authors.initials: YC
authors.lastname: Wang
authors.forename: Guo-yong
authors.initials: GY
authors.lastname: Huang
authors.forename: Liu-liang
authors.initials: LL
authors.lastname: Qin
authors.forename: Xian-min
authors.initials: XM
authors.lastname: Ge
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: He-min
authors.initials: HM
authors.lastname: Li
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000276:immunology / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000302:isolation & purification; D006801:Humans; D008251:Macaca; D008297:Male; D014418:Tupaiidae
chemical_list: D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens