Polyhydroxylated steroids and other constituents of the soft coral Nephthea chabroli.
Polyhydroxylated steroids and other metabolites were isolated from the soft coral Nephthea chabroli collected in South China Sea. The structures of two new compounds were determined to be 24-methylcholesta-9(11), 24(28)-diene-3beta,12alpha,19-triol and 4alpha-methyl-3beta,14beta-dihydroxy-5alpha-ergost-24(28)-en-23-one on the basis of spectroscopic analysis. Cytotoxic activities of the polyhydroxylated sterols were evaluated on prostate carcinoma LNCaP cell line.
Zhang
Weihan
W
Hutchison Medipharma Ltd., Shanghai, China. chect@cuhk.edu.hk
Liu
Wing Keung
WK
Che
Chun-Tao
CT
D000818:Animals; D037421:Anthozoa; D045744:Cell Line, Tumor; D006801:Humans; D006900:Hydroxylation; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
D013256:Steroids