title: Quantitative perfusion mapping of the human lung using 1H spin labeling.
abstract: OBJECTIVE
  To evaluate the feasibility and reproducibility of a noninvasive, rapid and quantitative pulmonary perfusion mapping method using a two-compartment tissue model in combination with a (1)H spin labeling technique.
  
  
  METHODS
  Ten healthy volunteers and three patients with cystic fibrosis (CF) were examined on a 1.5-T whole-body scanner. Global and selective lung T(1) maps based on an inversion recovery Snapshot FLASH technique were acquired from each subject with breath-holds at end-expiration. For comparison, corresponding Gd-DTPA-enhanced (1)H MR perfusion images were also obtained from each CF patient.
  
  
  RESULTS
  Quantitative perfusion maps were calculated from the global and selective T(1) maps. The measured perfusion rates of the upper right lung in volunteers ranged from 400 to 600 mL/100 g/minute. The method showed a high intra-study reproducibility and low relative errors. In CF-patients, perfusion defects detected using Gd-DTPA-enhanced MR imaging were also detected using the spin labeling method. The perfusion rates of diseased lung tissues were less than 200 mL/100 g/minute.
  
  
  CONCLUSIONS
  Noninvasive, robust and quantitative (1)H MR mapping of pulmonary perfusion was successfully performed using a rapid lung T(1) mapping in combination with spin labeling within the imaging slice. The proposed method has the potential to provide both important qualitative functional information and quantitative pulmonary perfusion rates in various lung diseases at various stages without the need of contrast agents.
authors.affiliation: Department of Physics, University of Würzburg, Würzburg, Germany.
authors.forename: Tungte
authors.initials: T
authors.lastname: Wang
authors.forename: Georg
authors.initials: G
authors.lastname: Schultz
authors.forename: Helge
authors.initials: H
authors.lastname: Hebestreit
authors.forename: Alexandra
authors.initials: A
authors.lastname: Hebestreit
authors.forename: Dietbert
authors.initials: D
authors.lastname: Hahn
authors.forename: Peter M
authors.initials: PM
authors.lastname: Jakob
mesh_terms: D000328:Adult; D003287:Contrast Media; D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000473:pathology; D005240:Feasibility Studies; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008168:Lung / Q000033:anatomy & histology / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008954:Models, Biological; D011652:Pulmonary Circulation / Q000502:physiology*; D012016:Reference Values; D015203:Reproducibility of Results; D013113:Spin Labels
chemical_list: D003287:Contrast Media; D013113:Spin Labels; D019786:Gadolinium DTPA