title: Concomitant boost of stratified target area with gamma knife radiosurgery: a treatment planning study.
abstract: Conventional Gamma Knife Stereotactic Radiosurgery (GKSRS) has been focused on delivering a single peripheral dose to the gross target volume based on the anatomic information derived from the magnetic resonance or computed tomography (CT) studies. In this study, we developed a treatment planning approach that allows a boost dose to be delivered concomitantly to the desired subtarget area while maintaining the peripheral isodose coverage of the target volume. The subtarget area is defined as the high-risk or the tumor burden areas based on the functional imaging information such as the magnetic resonance spectroscopy (MRS) studies or the physician's clinical diagnosis. Treatment plan comparisons were carried out between the concomitant boost plans and the conventional treatment plans using dose volume histogram (DVH), tissue volume ratio (TVR), and the maximum dose to the peripheral dose ratio (MD/PD) analysis. Using the concomitant boost approach, more conformal and higher dose was delivered to the desired subtarget area while maintaining the peripheral isodose coverage of the gross target volume (GTV). Additionally, the dose to the normal brain tissue was found to be equivalent between the concomitant boost plans and the conventional plans. As a result, we conclude that concomitant boost of a stratified target area is feasible for GKSRS.
authors.affiliation: Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore 21201, USA. lma001@umaryland.edu
authors.forename: Lijun
authors.initials: L
authors.lastname: Ma
authors.forename: Lawrence S
authors.initials: LS
authors.lastname: Chin
authors.forename: Steven J
authors.initials: SJ
authors.lastname: DiBiase
authors.forename: Rao
authors.initials: R
authors.lastname: Gullapalli
authors.forename: Andrew
authors.initials: A
authors.lastname: Kennedy
authors.forename: J Marc
authors.initials: JM
authors.lastname: Simard
authors.forename: Robert
authors.initials: R
authors.lastname: Slawson
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D016634:Radiosurgery / Q000379:methods*; D013813:Therapy, Computer-Assisted