title: [Extraskeletal myxoid chondrosarcoma of the nasopharynx].
abstract: Extraskeletal myxoid chondrosarcoma is a rare but distinct entity with special clinicopathological, immunohistochemical, cytogenetical and outcome features. This tumor developed from soft tissues. A few cases have been reported in the head and neck in the literature. We report two new cases of extraskeletal myxoid chrondrosarcoma presenting in such an unusual site: one involved the left nasal cavity of a 67-year-old man and the second the sphenoidal sinus of a 71-year-old woman. The microscopic examination revealed nests of round small cells dispersed in a myxoid stroma. The myxoid material was stained with Alcian Blue with and without hyaluronidase application whereas no PAS staining was observed. The immunohistochemical staining showed reactivity with S-100 protein and vimentin in two cases and with EMA in one case. These results allowed us to exclude other differential diagnoses: soft tissue tumors with a myxoid stroma (myxoma, myxoid liposarcoma and myxofibrosarcoma). No staining with anti-KL1 allowed us to exclude chordoma. Curative surgery was not possible. Both patients were given radiotherapy and the tumor regressed in one.
authors.affiliation: Service d'Anatomie et Cytologie Pathologiques, Hôpital Rangueil, Avenue Jean Poulhès, 31000 Toulouse cedex.
authors.forename: Valérie
authors.initials: V
authors.lastname: Jérôme-Marson
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Uro-Coste
authors.forename: Laetitia
authors.initials: L
authors.lastname: Lacoste-Collin
authors.forename: Anne
authors.initials: A
authors.lastname: Gomez-Brouchet
authors.forename: Elie
authors.initials: E
authors.lastname: Serrano
authors.forename: Marie-Bernadette
authors.initials: MB
authors.lastname: Delisle
mesh_terms: D000368:Aged; D002813:Chondrosarcoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000473:pathology*