title: The 5 Ps of acute ischemic stroke treatment: parenchyma, pipes, perfusion, penumbra, and prevention of complications.
abstract: Stroke is a treatable disease. Despite the therapeutic nihilism of the past, the advent of thrombolysis has changed the way stroke is approached. Acute ischemic stroke is a challenging and heterogeneous disease. Treatment needs to be based on an understanding of the underlying pathophysiology of ischemia. Interventions are designed to improve neuronal salvage and outcome. The underlying tenets of stroke therapy focus on the brain parenchyma, arterial flow (pipes), perfusion, the ischemic milieu or penumbra, and prevention of complications. This article focuses on the practical issues of ischemic stroke care, with a brief review of supporting literature.
authors.affiliation: Department of Neurology, Ochsner Foundation Clinic and Hospital, New Orleans, LA 70121, USA. rfelberg@Ochsner.org
authors.forename: Robert A
authors.initials: RA
authors.lastname: Felberg
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Naidech
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D020521:Stroke / Q000145:classification / Q000188:drug therapy / Q000503:physiopathology; D015912:Thrombolytic Therapy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D006493:Heparin; D001241:Aspirin