title: Biological dosimetry of complex ion radiation fields.
abstract: We report on a set of cell survival experiments performed in complex field combinations of therapeutic 12C ion beams. CHO cells were exposed to the superposition of two or three fields of 12C ions arranged in a similar way to real patient treatments. Two-dimensional survival distributions were measured and compared with the predictions of the TRiP98 treatment planning system. Good agreement was found in general. In particular the method of tissue sparing using dose ramps could be verified.
authors.affiliation: GSI Biophysik, Planck-Str. 1, D-64291 Darmstadt, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Krämer
authors.forename: J F
authors.initials: JF
authors.lastname: Wang
authors.forename: W
authors.initials: W
authors.lastname: Weyrather
mesh_terms: D000818:Animals; D016466:CHO Cells; D002250:Carbon Radioisotopes / Q000032:analysis*; D002470:Cell Survival / Q000528:radiation effects*; D003198:Computer Simulation; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D007477:Ions; D008954:Models, Biological; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D002250:Carbon Radioisotopes; D007477:Ions