Coral as a carrier for recombinant human bone morphogenetic protein-2.
By combining coral with recombinant human bone morphogenetic protein-2 (rhBMP-2), rhBMP-2/coral composite was obtained in this study. Following implantation of the composite into the muscle pouches of mice, cartilage growth was induced in the pores or on the surface of the implants at one week, woven bone at three week and lamellar bone with bone marrow at six week, and coral was absorbed partially. The induced formation of endochondral bone was time-related and rhBMP-2 dose-related. The results of this study indicate that the composite possesses a superior ability of osteogenesis, and coral acts as one of the most suitable rhBMP-2 slowrelease carriers currently available. The composite will be a new type of bone substitute to be used in orthopaedics and maxillofacial surgery.
Zhang
S
S
Department of Stomatology, Nanjing General Hospital of PLA, Nanjing 210002.
Mao
T
T
Meng
Z
Z
Wang
H
H
D000818:Animals; D037421:Anthozoa; D001853:Bone Marrow / Q000254:growth & development; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage* / Q000494:pharmacology; D018786:Bone Substitutes; D002356:Cartilage / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D006801:Humans; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage / Q000494:pharmacology; D051379:Mice; D010012:Osteogenesis / Q000187:drug effects*; D011994:Recombinant Proteins / Q000494:pharmacology; D013997:Time Factors; D016212:Transforming Growth Factor beta
C525718:BMP2 protein, human; C525719:Bmp2 protein, mouse; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D004337:Drug Carriers; D008419:Materia Medica; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2