An efficient synthesis of the C-23 deoxy, 17 alpha-hydroxy South 1 hemisphere and its cephalostatin 1 analog.
[reaction: see text] Methods for functionalization of the D ring of diene 1 were investigated. This study led to efficient syntheses of 3 and the subsequent 23'-deoxy,17'alpha-hydroxy cephalostatin 1 analog (4). The bioactivity data of 2 and 4 are in the low nanomolar range for a 10-cell-line minipanel.
Li
Wei
W
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
Fuchs
Philip L
PL
D002460:Cell Line; D010619:Phenazines / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013256:Steroids
D010619:Phenazines; D013141:Spiro Compounds; D013256:Steroids; C454806:cephalostatin I