title: Cutaneous ulceration caused by methotrexate.
abstract: Methotrexate has been associated with the development of skin ulceration in small numbers of patients with psoriasis. We describe a 58-year-old man with a 15-year history of plaque-type psoriasis. He had been treated with methotrexate therapy (15 mg orally per week for 32 weeks) and had ulcers develop within psoriatic plaques on both elbows, on the mucosal aspect of the lower lip, and in an appendectomy scar on the right lower quadrant of the abdomen. Ulcers healed upon discontinuation of methotrexate, but the scar eroded again upon reintroduction of methotrexate.
authors.affiliation: Department of Dermatology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029, USA.
authors.forename: Dana W
authors.initials: DW
authors.lastname: Kazlow
authors.forename: David
authors.initials: D
authors.lastname: Federgrun
authors.forename: Stephen
authors.initials: S
authors.lastname: Kurtin
authors.forename: Mark G
authors.initials: MG
authors.lastname: Lebwohl
mesh_terms: D000284:Administration, Oral; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D011565:Psoriasis / Q000175:diagnosis / Q000188:drug therapy*; D018570:Risk Assessment; D012720:Severity of Illness Index; D012883:Skin Ulcer / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D008727:Methotrexate