title: Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia.
abstract: Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug.
authors.affiliation: Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: Aimable
authors.initials: A
authors.lastname: Nahimana
authors.forename: Meja
authors.initials: M
authors.lastname: Rabodonirina
authors.forename: Jannik
authors.initials: J
authors.lastname: Helweg-Larsen
authors.forename: Isabelle
authors.initials: I
authors.lastname: Meneau
authors.forename: Patrick
authors.initials: P
authors.lastname: Francioli
authors.forename: Jacques
authors.initials: J
authors.lastname: Bille
authors.forename: Philippe M
authors.initials: PM
authors.lastname: Hauser
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology; D004271:DNA, Fungal / Q000032:analysis; D004094:Dihydropteroate Synthase / Q000235:genetics* / Q000378:metabolism; D025141:Drug Resistance, Fungal / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D011010:Pneumocystis / Q000187:drug effects / Q000235:genetics*; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy / Q000382:microbiology*; D012008:Recurrence; D013449:Sulfonamides / Q000494:pharmacology*; D013450:Sulfones / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D004271:DNA, Fungal; D013449:Sulfonamides; D013450:Sulfones; D004094:Dihydropteroate Synthase