Safety of the newer antihypertensive agents in children.
Hypertension is relatively uncommon in children and few children receive antihypertensive medications. This article reviews the safety of calcium channel blockers, angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in children with hypertension. While the newer antihypertensive agents appear to be well-tolerated by children, further studies are needed to determine the safety profile across the developmental continuum, with chronic dosing and in children with complex hypertension.
Blowey
Douglas L
DL
Pediatric Nephrology, School of Medicine, University of Missouri-Kansas City, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA. dblowey@cmh.edu
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology; D007223:Infant; D012449:Safety
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers