title: Alzheimer's disease disrupts arithmetic fact retrieval processes but not arithmetic strategy selection.
abstract: Three groups of healthy younger adults, healthy older adults, and probable AD patients, performed an addition/number comparison task. They compared 128 couples of additions and numbers (e.g., 4 + 9 15) and had to identify the largest item for each problem by pressing one of two buttons located under each item. Manipulations of problem characteristics (i.e., problem difficulty and splits between correct sums and proposed numbers) enabled us to examine strategy selection and specific arithmetic fact retrieval processes. Results showed that arithmetic facts retrieval processes, which were spared with aging, were impaired in AD patients. However, AD patients were able to switch between strategies across trials according to problem characteristics as well as healthy older adults, and less systematically than healthy younger adults. We discuss implications of these findings for further understanding AD-related differences in arithmetic in particular, and problem solving in general.
authors.affiliation: CNRS, Université de Provence, Marseille, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Duverne
authors.forename: Patrick
authors.initials: P
authors.lastname: Lemaire
authors.forename: Bernard François
authors.initials: BF
authors.lastname: Michel
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications*; D001007:Anxiety / Q000175:diagnosis; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology*; D003863:Depression / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008433:Mathematics; D008569:Memory Disorders / Q000175:diagnosis* / Q000209:etiology*; D009483:Neuropsychological Tests; D012647:Self-Assessment; D012720:Severity of Illness Index