title: Semen parameters in patients with unilateral testicular cancer compared to patients with other malignancies.
abstract: OBJECTIVE
  The aim of our study was to evaluate pretreatment semen quality in patients with unilateral testicular cancer in comparison to semen parameters of patients suffering from other malignancies.
  
  
  METHODS
  Semen analysis according to WHO recommendations were performed in 16 patients suffering from unilateral testicular cancer (group 1) and in 21 patients who were diagnosed to have other malignant tumors (group 2: non-Hodgkin's lymphoma: n=7, Hodgkin's disease: n=6, leukemia: n=3, osteosarcoma: n=2, rectal cancer: n=2, thyroid carcinoma: n=1) prior to anti-cancer treatment.
  
  
  RESULTS
  Normozoospermia was observed in none of the testicular cancer patients but in five of the other patients ( p=0.047). Sperm concentration was significantly decreased in the patients of group 1 compared to those of group 2 (18.7+/-22.3x10(6)/ml versus 35.6+/-31.3x10(6)/ml, p=0.03). The percentage of rapid progressive motile spermatozoa was significantly less in testicular cancer patients than in patients suffering from other malignancies (WHO group a: 1.1+/-2.0% versus 4.7+/-5.6%, p=0.02). Normal morphological findings of spermatozoa were found in a smaller percentage in group 1 (16.2+/-6.0% versus 26.1+/-18.0%, p=0.03).
  
  
  CONCLUSIONS
  Our investigations revealed that especially testicular cancer has an adverse influence on sperm quality. Hence, we advise careful and sufficient cryopreservation of semen in those patients taking the negative impact of cytotoxic treatments on semen parameters into account.
authors.affiliation: Department of Obstetrics and Gynecology, University of Würzburg, Josef-Schneider-Strasse 4, 97080 Würzburg, Germany. frauenklinik@mail.uni-wuerzburg.de
authors.forename: Stefanie
authors.initials: S
authors.lastname: Bussen
authors.forename: Marc
authors.initials: M
authors.lastname: Sütterlin
authors.forename: Thomas
authors.initials: T
authors.lastname: Steck
authors.forename: Johannes
authors.initials: J
authors.lastname: Dietl
mesh_terms: D000328:Adult; D015925:Cryopreservation; D018237:Germinoma / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D009919:Orchiectomy; D012661:Semen / Q000166:cytology*; D012662:Semen Preservation; D018239:Seminoma / Q000473:pathology / Q000601:surgery; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000502:physiology*; D013736:Testicular Neoplasms / Q000473:pathology* / Q000601:surgery