Effects of some traditional plant extracts on rat oestrous cycle compared with Clomid.
It is well known that the plant kingdom contains numerous bioactive substances affecting the regulation of reproduction. The present study was undertaken to examine the putative contraceptive effects of three traditional plant extracts from Côte d'Ivoire Pharmacopea. It concerns Afrormosia laxiflora (Papilionacea), Pterocarpus erinaceus (Papilionacea) and Cola nitida (Sterculiacea) stem bark. Data showed that treatment of rats with these plant extracts induced ovulation and oestrous cycle blockade at the dioestrous II stage. The analysis of the principal hormones involved in oestrous cycle regulation showed that the plant extracts decreased gonadotropin release (both LH and FSH). In fact, A. laxiflora, P. erinaceus and C. nitida extracts inhibited gonadotropin release as an antiestrogen-like substance.
Benie
T
T
Laboratoire Endocrinologie et de Biologie de la Reproduction, UFR Biosciences, Université de Cocody, 22 BP 582 Abidjan, Côte d'Ivoire.
Duval
J
J
Thieulant
M-L
ML
D000818:Animals; D002996:Clomiphene / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D004965:Estrogen Antagonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D030762:Estrous Cycle / Q000187:drug effects*; D007887:Fabaceae; D005260:Female; D006062:Gonadotropins / Q000378:metabolism; D007274:Injections, Intraperitoneal; D019660:Malvaceae; D016488:Medicine, African Traditional; D010060:Ovulation / Q000187:drug effects*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D035721:Pterocarpus; D051381:Rats; D017208:Rats, Wistar; D011980:Receptors, Progesterone / Q000187:drug effects; D014599:Uterus / Q000187:drug effects
D004965:Estrogen Antagonists; D006062:Gonadotropins; D010936:Plant Extracts; D011980:Receptors, Progesterone; D002996:Clomiphene; D004958:Estradiol