Mechanical injury and repair of cells.
OBJECTIVE
To concisely review the field of cell plasma membrane disruption (torn cell surface) and repair.


RESULTS
Plasma membrane disruption is a common form of cell injury under physiologic conditions, after trauma, in certain muscular dystrophies, and during certain forms of clinical intervention. Rapid repair of a disruption is essential to cell survival and involves a complex and active cell response that includes membrane fusion and cytoskeletal activation. Tissues, such as cardiac and skeletal muscle, adapt to a disruption injury by hypertrophying. Cells adapt by increasing the efficiency of their resealing response.


CONCLUSIONS
Plasma membrane disruption is an important cellular event in both health and disease. The disruption repair mechanism is now well understood at the cellular level, but much remains to be learned at the molecular level. Cell and tissue level adaptational responses to the disruption either prevent its further occurrence or facilitate future repairs. Therapeutically useful drugs might result if, using this accumulating knowledge, chemical agents can be developed that can enhance repair or adaptive responses.
Miyake
Katsuya
K
Department of Cellular Biology and Anatomy and the Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, 30912, USA.
McNeil
Paul L
PL
D000222:Adaptation, Physiological / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D002470:Cell Survival / Q000502:physiology*; D003422:Critical Care; D016638:Critical Illness / Q000628:therapy*; D005089:Exocytosis / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000502:physiology; D006801:Humans; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000503:physiopathology* / Q000628:therapy
D005346:Fibroblast Growth Factors