Signaling molecules as therapeutic targets in allergic diseases.
A molecular understanding of physiologic and pathologic processes requires complete knowledge about the signal transduction mechanism of involved cells. Signal transduction research is a rapidly growing field in basic science. Unlike intercellular inflammatory mediators, signaling molecules show less functional redundancy. This allows inhibition of multiple cytokines/mediators by blocking one common signaling molecule. Interference with signaling pathways has shown significant potential for inhibition of fundamental processes as well as clinical phenotype of allergic diseases. The purpose of this review was to provide a theoretical classification of signaling molecules based on their function and to analyze various strategies for developing effective signaling inhibitors for allergic diseases.
Gorska
Magdalena M
MM
Division of Allergy and Immunology, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver, CO, USA.
Alam
Rafeul
R
D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000235:genetics; D010641:Phenotype; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D012313:RNA / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects*
D012313:RNA