Strains of Streptococcus pyogenes from severe invasive infections bind HEp2 and HaCaT cells more avidly than strains from uncomplicated infections.
Epidemiologically unrelated Streptococcus pyogenes strains isolated from blood, throat, and skin were assayed for adherence to HEp2 and HaCaT cells. Invasive isolates showed significantly higher avidity for these cell lines than isolates from skin and throat. In general, S. pyogenes showed greater binding to HaCaT cells than to HEp2 cells.
Edwards
Mandy L
ML
Menzies School of Health Research. Cooperative Research Centre for Aboriginal and Tropical Health, Darwin, Australia.
Fagan
Peter K
PK
Smith-Vaughan
Heidi
H
Currie
Bart J
BJ
Sriprakash
Kadaba S
KS
D001422:Bacterial Adhesion / Q000502:physiology*; D006801:Humans; D013290:Streptococcal Infections / Q000175:diagnosis*; D013297:Streptococcus pyogenes / Q000145:classification / Q000302:isolation & purification* / Q000502:physiology*; D014407:Tumor Cells, Cultured