Separation of triplet repeat DNA by capillary electrophoresis and the conformational analysis by atomic force microscope.
We investigated the relationship between electrophoretic behaviors and higher order structures of triplet repeat DNA fragments by means of capillary electrophoresis and atomic force microscopy (AFM). It was suggested that the mobility difference between triplet repeat DNA and random sequence DNA should be correlated to differences in their dynamic conformation.
Nakagawa
T
T
Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Tokushima, Tokushima 770-8505, Japan.
Ueda
M
M
Baba
Y
Y
D004247:DNA / Q000737:chemistry* / Q000302:isolation & purification*; D019075:Electrophoresis, Capillary; D006801:Humans; D066298:In Vitro Techniques; D018625:Microscopy, Atomic Force; D009690:Nucleic Acid Conformation; D019680:Trinucleotide Repeat Expansion; D018911:Trinucleotide Repeats
D004247:DNA