Parotid carcinoma after autologous bone marrow transplantation for relapsed nephroblastoma.
Abdominal irradiation, especially if associated with doxorubicin administration, increases the risk of a secondary malignant neoplasm (SMN) after treatment of nephroblastoma. Secondary malignant salivary tumors are rare and usually occur in patients with previous cranial irradiation. The authors describe the case of a parotid mucoepidermoid carcinoma arising 13 years after diagnosis of nephroblastoma. This patient showed no characteristics reported in the literature as statistically significant for the development of an SMN. The authors believe that long-term, regular clinical examination is necessary even in patients at low risk of developing an SMN.
Manzitti
Carla
C
Department of Pediatric Hematology/Oncology, G Gaslini Children's Hospital, Genoa, Italy.
Mereu
Paola
P
Haupt
Riccardo
R
Di Blasi
Arturo
A
Bellani
Franca Fossati
FF
Dallorso
Sandro
S
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000209:etiology* / Q000473:pathology*; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D008297:Male; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000473:pathology; D010307:Parotid Neoplasms / Q000209:etiology* / Q000473:pathology*; D013997:Time Factors; D009396:Wilms Tumor / Q000188:drug therapy* / Q000532:radiotherapy*
D004317:Doxorubicin