The immunology of psoriasis and biologic immunotherapy.
In this review, we will discuss the immunological basis for psoriasis with special emphasis on the role of effector T cells. With the understanding of this immunologic process, we will present a model for the development of targeted immune response modifiers, termed biologic immunotherapies, and their potential role for the benefit of patients with psoriasis.
Mehlis
Stephanie L
SL
Division of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Gordon
Kenneth B
KB
D016207:Cytokines / Q000378:metabolism / Q000627:therapeutic use; D015195:Drug Design; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008213:Lymphocyte Activation; D011565:Psoriasis / Q000276:immunology* / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines