Electrochemical characterization and DNA-binding property of dipyridophenazine complexes of osmium (II).
Novel dipyridophenazine (DPPZ) complexes of osmium (II), [Os(L)2(DPPZ)]2+ [L = 2,2'-bipyridyl (bpy)(1), 4,4'-diamino-2,2'-bipyridyl (DA-bpy)(2), 4,4'-dimethyl-2,2'-bipyridyl(DM-bpy)(3), and 4,4'-dicarboxyl-2,2'-bipyridyl (DC-bpy)(4)] have been synthesized and characterized. The DNA-binding properties of the complexes were studied by electrochemical methods. As the results, complex 2 shows higher affinity to DNA than other osmium complexes. The binding constant, K of complex 2 to calf thymus DNA has been determined to be 2.3 x 10(7) M-1 by normal pulse voltammetry (NPV).
Maruyama
K
K
Department of Chemical Science and Technology, University of Tokushima, Minamijosanjima 2-1, Tokushima 770-8506, Japan.
Mishima
Y
Y
Nakabayashi
Y
Y
Motonaka
J
J
D000818:Animals; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D004563:Electrochemistry; D066298:In Vitro Techniques; D007700:Kinetics; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism*; D009992:Osmium / Q000737:chemistry* / Q000378:metabolism*
C476357:(4,4'-diamino-2,2'-bipyridine)(dipyrido(a-2',3'-c)phenazine)osmium(II); D009942:Organometallic Compounds; D009992:Osmium; D004247:DNA