Necrolytic migratory erythema as the only presenting sign of a glucagonoma.
We describe a 39-year-old man with a 3-year history of a recalcitrant psoriasiform eruption that was accentuated in the intertriginous areas. Hsitopathology was consistent with psoriasis. A glucagon level was 744 pg/mL with the upper limit of normal being 130 pg/mL. Computed tomographic scan of the abdomen revealed a 5-cm mass in the tail of the pancreas. The tumor was removed and found to be a glucagonoma (pancreatic islet tumor). The clinical eruption resolved promptly with surgical excision. Neither the clinical eruption nor the tumor has recurred for 6 months. The course of disease confirms the diagnosis of necrolytic migratory erythema associated with a glucagonoma.
Johnson
Sandra Marchese
SM
Departments of Dermatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA. Johnsonsandram@exchange.uams.edu
Smoller
Bruce R
BR
Lamps
Laura W
LW
Horn
Thomas D
TD
D000328:Adult; D003937:Diagnosis, Differential; D004890:Erythema / Q000209:etiology* / Q000473:pathology; D005935:Glucagonoma / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D009336:Necrosis; D010190:Pancreatic Neoplasms / Q000150:complications / Q000175:diagnosis*