title: Amygdalar and hippocampal theta rhythm synchronization during fear memory retrieval.
abstract: The amygdalohippocampal circuit plays a pivotal role in Pavlovian fear memory. We simultaneously recorded electrical activity in the lateral amygdala (LA) and the CA1 area of the hippocampus in freely behaving fear-conditioned mice. Patterns of activity were related to fear behavior evoked by conditioned and indifferent sensory stimuli and contexts. Rhythmically synchronized activity at theta frequencies increased between the LA and the CA1 after fear conditioning and became significant during confrontation with conditioned fear stimuli and expression of freezing behavior. Synchronization of theta activities in the amygdalohippocampal network represents a neuronal correlate of conditioned fear, apt to improve neuronal communication during memory retrieval.
authors.affiliation: Institut für Physiologie, Otto-von-Guericke-Universität, Leipziger Strasse 44, Magdeburg D-39120, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Seidenbecher
authors.forename: T Rao
authors.initials: TR
authors.lastname: Laxmi
authors.forename: Oliver
authors.initials: O
authors.lastname: Stork
authors.forename: Hans-Christian
authors.initials: HC
authors.lastname: Pape
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal; D003213:Conditioning, Psychological; D003463:Cues; D004594:Electrophysiology; D004597:Electroshock; D005239:Fear; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D008568:Memory; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity; D013826:Theta Rhythm