title: A concise route to benzofused macrolactones via ynolides: cycloproparadicicol.
abstract: A new facile synthesis has been developed for nanomolar Hsp90 inhibitor, cycloproparadicicol (2). Our approach relied on cobalt-complexation promoted RCM, in combination with tandem Diels-Alder/retro-Diels-Alder reactions to assemble the resorcycinylic macrolactone.
authors.affiliation: Laboratory for Bioorganic Chemistry, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Yang
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Danishefsky
mesh_terms: D003500:Cyclization; D003521:Cyclopropanes / Q000134:cerebrospinal fluid*; D007783:Lactones / Q000134:cerebrospinal fluid*; D018942:Macrolides / Q000138:chemical synthesis*; D012118:Resorcinols / Q000138:chemical synthesis*
chemical_list: D003521:Cyclopropanes; D007783:Lactones; D018942:Macrolides; D012118:Resorcinols; C477936:cycloproparadicicol