title: [Albumin kinetics in patients with severe sepsis].
abstract: OBJECTIVE
  To explore the mechanism of hypoalbuminemia in patients with severe sepsis.
  
  
  METHODS
  I(125)-labeled albumin was administered intravenously to 10 health volunteers and 10 patients with severe sepsis. Blood samples were taken at 0, 1, 2, 4, 8, 12, 24 hours and 2, 3, 4, 5, 6, 7, 9, 11, 13, 15, 18, 22, 25 days for the measurement of the dose of gamma-radiation and the curve of concentration and time. Then the half-life time (t(1/2)), apparent volume of distribution (V(d)) and transportation rate (K(12)) from center compartment to side compartment of albumin were calculated.
  
  
  RESULTS
  The half-life time in septic group was obviously shorter than that in control group (8.2 +/- 1.4 vs. 12.5 +/- 1.7, P < 0.01). The transportation rate in the septic group was higher than that in the control group [(4.4 +/- 1.9) x 10(-2)/h vs. (2.4 +/- 0.6) x 10(-2)/h, P < 0.05]. There was no significant difference in apparent volume of distribution between the two groups.
  
  
  CONCLUSIONS
  In patients with severe sepsis, the distribution rate of albumin from vessel to tissue was obviously increased and the decomposition rate of albumin was markedly improved.
authors.affiliation: Research Institute of General Surgery, Nanjing General Hospital of People's Liberation Army, Nanjing 210002, China.
authors.forename: Wei-qin
authors.initials: WQ
authors.lastname: Li
authors.forename: Xin-ying
authors.initials: XY
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.forename: Heng-shan
authors.initials: HS
authors.lastname: Tan
authors.forename: Jian-zhong
authors.initials: JZ
authors.lastname: Rui
authors.forename: Yang
authors.initials: Y
authors.lastname: Bao
authors.forename: Zhu-fu
authors.initials: ZF
authors.lastname: Quan
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Jie-shou
authors.initials: JS
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D012709:Serum Albumin