Cholesteryl ester oxidation products in atherosclerosis.
Lipid oxidation products are formed at sites of increased oxidant stress and have been shown to accumulate in atherosclerotic lesions. Although recent studies have focused on the formation and metabolism of oxidized lipids, very little is known about their biological activities and possible (patho)physiological functions. Oxidation of cholesteryl esters containing unsaturated fatty acids leads to the formation of hydroperoxides that are either reduced to alcohols or degrade into biologically active "core-aldehydes". In this review, the mechanisms of formation and metabolic fate of oxidized cholesteryl esters, their occurrence, as well as possible biological activities are discussed. Based on the current knowledge, cholesteryl ester oxidation leads to the formation of biologically active substances, which could actively contribute to the progression of atherosclerotic lesions and their resulting complications.
Leitinger
Norbert
N
Department of Vascular Biology and Thrombosis Research, University of Vienna, Schwarzspanierstrasse 17, 1090 Vienna, Austria. norbert.leitinger@univie.ac.at
D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism*; D002788:Cholesterol Esters / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D010084:Oxidation-Reduction; D010949:Plasma / Q000378:metabolism
D000447:Aldehydes; D002788:Cholesterol Esters; C021976:cholesteryl linoleate; D020928:Mitogen-Activated Protein Kinases