Evidence of Toscana virus circulation in Umbria: first report.
To evaluate, for the first time, circulation and clinical expression of Toscana virus (ToSv) in Umbria region we studied: (1) 93 cases of aseptic meningitis and meningoencephalitis admitted to our Department from 1989 to 2001 with negative results for common neurotropic virus; (2) 50 healthy subjects. Specific antibodies (IgM and IgG) anti-TOSv were found in 36.6% of aseptic meningitis, in 6.06% of meningoencephalitis and (IgG) in 16% of healthy subjects.
Francisci
D
D
Clinica Malattie Infettive, Policlinico Monteluce, Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy. francisd@unipg.it
Papili
R
R
Camanni
G
G
Morosi
S
S
Ferracchiato
N
N
Valente
M
M
Ciufolini
M G
MG
Baldelli
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D007558:Italy / Q000453:epidemiology; D008297:Male; D008581:Meningitis / Q000097:blood* / Q000453:epidemiology / Q000821:virology; D008590:Meningoencephalitis / Q000097:blood / Q000453:epidemiology / Q000821:virology; D008875:Middle Aged; D029301:Sandfly fever Naples virus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D016036:Seroepidemiologic Studies
D007074:Immunoglobulin G; D007075:Immunoglobulin M