title: Fluorescence microscopic visualization of a DNA-cationic fullerene complex.
abstract: Cationic fullerene derivative 1, which is soluble in aqueous medium, bound to double stranded DNA. Observation of Coliphage T4 DNA in the absence and presence of 1 by fluorescence microscopy suggested that 1 bound to DNA along its groove. Upon irradiation of visible light on the DNA complex of 1, DNA was cleaved dramatically. The process of DNA photo-cleavage could be monitored continuously by fluorescence microscopy.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Iwataki
authors.forename: T
authors.initials: T
authors.lastname: Hatta
authors.forename: K
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: O
authors.initials: O
authors.lastname: Tsuge
authors.forename: M
authors.initials: M
authors.lastname: Takagi
authors.forename: S
authors.initials: S
authors.lastname: Takenaka
mesh_terms: D017122:Bacteriophage T4 / Q000737:chemistry; D001665:Binding Sites; D002412:Cations; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects / Q000648:ultrastructure*; D004279:DNA, Viral / Q000737:chemistry / Q000528:radiation effects / Q000648:ultrastructure; D037741:Fullerenes / Q000737:chemistry* / Q000528:radiation effects; D066298:In Vitro Techniques; D046911:Macromolecular Substances; D008856:Microscopy, Fluorescence; D008958:Models, Molecular; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D010777:Photochemistry
chemical_list: D002412:Cations; D004279:DNA, Viral; D037741:Fullerenes; D046911:Macromolecular Substances; D004247:DNA