title: Replicative helicase loaders: ring breakers and ring makers.
abstract: Helicase loaders transfer the ring-shaped replicative helicases onto DNA. They assort into two classes: ring breakers, which place stabile hexameric rings on DNA via transient gaps at subunit interfaces; and helicase makers, which assemble hexameric rings around DNA from monomeric helicase units.
authors.affiliation: Howard Hughes Medical Institute, 1230 York Ave., New York, NY 10021, USA.
authors.forename: Megan J
authors.initials: MJ
authors.lastname: Davey
authors.forename: Mike
authors.initials: M
authors.lastname: O'Donnell
mesh_terms: D004247:DNA / Q000378:metabolism*; D004265:DNA Helicases / Q000378:metabolism*; D004261:DNA Replication / Q000235:genetics*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D008958:Models, Molecular
chemical_list: C071702:DnaC protein, E coli; D029968:Escherichia coli Proteins; D004247:DNA; D004265:DNA Helicases