title: [Angiotensin1-receptor antagonist losartan. Part I. Basic clinical pharmacology].
abstract: This is the initial part in a series of papers dealing with various aspects of clinical pharmacology of the first AT(1)-receptor antagonist losartan and its therapeutic use in hypertension, diabetic nephropathy, chronic heart failure, and acute phase of myocardial infarction. Mechanisms of action, pharmacological effects of losartan and other AT(1)-receptor antagonists, as well as data on pharmacokinetics of losartan, its long term tolerability and safety are reviewed in this communication.
authors.forename: B A
authors.initials: BA
authors.lastname: Sidorenko
authors.forename: D V
authors.initials: DV
authors.lastname: Preobrazhenskiĭ
authors.forename: T M
authors.initials: TM
authors.lastname: Stetsenko
authors.forename: N V
authors.initials: NV
authors.lastname: Malysheva
authors.forename: V V
authors.initials: VV
authors.lastname: Tsurko
authors.forename: E V
authors.initials: EV
authors.lastname: Tarykina
mesh_terms: D057911:Angiotensin Receptor Antagonists; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D019808:Losartan / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D010601:Pharmacology, Clinical / Q000379:methods*; D044140:Receptor, Angiotensin, Type 1; D012697:Serine Endopeptidases
chemical_list: D057911:Angiotensin Receptor Antagonists; D000889:Anti-Arrhythmia Agents; D044140:Receptor, Angiotensin, Type 1; D012697:Serine Endopeptidases; C061710:angiotensin II-producing serum enzyme III; D019808:Losartan