[Study of the effect of a short-chain vitamin E analog on the structural and functional state of the plasma membrane of cardiomyocytes in vitro].
The results of study of influence of C6-analog of alpha-tocopherol on the structural and functional state of cardiomyocytes plasma membranes (CPM) in vitro are given. Under condition of incubation of CPM of intact animals the level of phospholipids was decreased, the level of fatty acids was increased, intensity of processes of free-radical oxidation (FRO) was significantly increased and activity of Na+, K(+)-ATPase was decreased in control samples of CPM. The analog of vitamin E supplementation at a concentration of 10 mg/ml of the medium significantly prevented the development of these changes. All of these can be evidence of effective membranes protective action of C6-analog of vitamin E on CPM.
Donchenko
H V
HV
Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv.
Kuchmenko
O B
OB
Mkhitarian
L S
LS
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D002478:Cells, Cultured; D005227:Fatty Acids / Q000378:metabolism; D005609:Free Radicals; D009206:Myocardium / Q000166:cytology*; D010743:Phospholipids / Q000378:metabolism; D011817:Rabbits; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013329:Structure-Activity Relationship; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology*
D005227:Fatty Acids; D005609:Free Radicals; D010743:Phospholipids; D014810:Vitamin E; D000254:Sodium-Potassium-Exchanging ATPase