[Effects of NaBT and NSAIDs on colorectal adenoma-carcinoma cells].
OBJECTIVE
We investigated the primary adenoma cells and HT-29 cells in an attempt to know whether NaBT and two NSAIDs (aspirin and NS-398) could be used as effective adjuvant for reducing cell proliferation, and to explore the possible mechanisms therein involved.


METHODS
MTT was employed in detecting the anti-proliferative effects on both adenoma and HT-29 culture cells.


RESULTS
Both butyrate and NSAIDs could inhibit the proliferation of cells. The effects of the NSAIDs could be synergistically strengthened by combining with butyrate.


CONCLUSIONS
NaBT and the two NSAIDs could inhibit the cell proliferation when used separately, and a combination of butyrate with aspirin or NS-398 could enhance the inhibitory effects.
Zhang
Zhihong
Z
Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China.
Ouyang
Qin
Q
Gan
Huatian
H
D000230:Adenocarcinoma / Q000473:pathology*; D000236:Adenoma / Q000473:pathology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001241:Aspirin / Q000494:pharmacology; D002087:Butyrates / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000473:pathology*; D005434:Flow Cytometry / Q000379:methods; D019073:HT29 Cells; D006801:Humans; D009578:Nitrobenzenes / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002087:Butyrates; D009578:Nitrobenzenes; D013449:Sulfonamides; C080955:N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; D001241:Aspirin