title: [Methodological issues relevant to clinical research in rare diseases].
authors.affiliation: Direction Médicale, Laboratoire Aventis, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Dib
authors.forename: V
authors.initials: V
authors.lastname: Meininger
authors.forename: J-P
authors.initials: JP
authors.lastname: Boissel
mesh_terms: D000818:Animals; D006801:Humans; D035583:Rare Diseases / Q000175:diagnosis*; D012106:Research / Q000458:organization & administration*