The D4Mit12 locus on mouse chromosome 4 provides susceptibility to both gamma-ray-induced and N-methyl-N-nitrosourea-induced thymic lymphomas.
Low-penetrance genes control different susceptibilities to gamma-ray-induced thymic lymphomas in mouse strains. Our previous genetic analyses with backcross mice between BALB/c and MSM strains and congenic lines localized one such gene near the D4Mit12 locus on chromosome 4. N-Methyl-N-nitrosourea (MNU) is a guanine base-alkylating agent and differs from gamma-radiation in its mechanism of mutagenic action. Accordingly, in this study, we examined whether or not the locus also provides susceptibility to MNU-induced thymic lymphomas using 84 offsprings derived from congenic mice for D4Mit12. Association analysis provided a suggestive linkage at D4Mit12 (P = 0.0075) and the linkage was sustained by the peak of likelihood ratio statistical values being at the same position as that for the gamma-ray-induced lymphomas. The results strongly suggest that the BALB/c allele near D4Mit12 is associated with susceptibility to lymphomas induced by two carcinogenic agents having different mechanisms of mutagenic action.
Sato
Hiroki
H
Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8122, Asahimachi, Japan.
Tamura
Yasushi
Y
Ochiai
Yukie
Y
Kodama
Yasumitsu
Y
Hatakeyama
Katsuyoshi
K
Niwa
Ohtsura
O
Kominami
Ryo
R
D000818:Animals; D002874:Chromosome Mapping; D017931:DNA Primers; D005720:Gamma Rays; D005819:Genetic Markers; D008223:Lymphoma / Q000139:chemically induced / Q000235:genetics*; D008770:Methylnitrosourea; D051379:Mice; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D013953:Thymus Neoplasms / Q000139:chemically induced / Q000235:genetics*
D017931:DNA Primers; D005819:Genetic Markers; D008770:Methylnitrosourea