title: Soluble E-selectin and soluble ICAM-1 levels as markers of the activity of atopic dermatitis in children.
abstract: The expression of adhesion molecules is up-regulated in the skin of atopic dermatitis (AD) patients, and the levels of the soluble adhesion molecules sE-selectin and sICAM-1 have been reported to reflect the endothelial activation in the skin of AD patients. The objective of the study was to investigate the relationship between symptom score and levels of sE-selectin, sICAM-1 and sVCAM-1 before and after 2 weeks of treatment. Eighteen children with an exacerbation of AD were admitted and treated with corticosteroid dilutions under occlusive wet dressings (wet-wrap treatment). Symptom score (objective SCORAD) and levels of sE-selectin, sICAM-1, and sVCAM-1 were assessed before and after 2 weeks of treatment. A significant correlation between the objective SCORAD before treatment and the level of sE-selectin (p < 0.05), but not the level of sICAM-1 (p = 0.7) or sVCAM-1 (p = 0.5) was observed. The treatment resulted in a high degree of remission, which was reflected by a significant decrease in the level of sICAM-1 (p < 0.01), whereas there was only a trend in the level of sE-selectin to decrease (p = 0.08). The level of sE-selectin after 2 weeks of treatment still correlated significantly with the objective SCORAD before treatment (p < 0.005). Soluble E-selectin is a relative objective marker for the severity of AD. SCORAD is a treatment-sensitive symptom of AD, whereas E-selectin may be a more stable underlying systemic representation of AD.
authors.affiliation: Department of Dermato-Venereology (Pediatric Dermatology), Erasmus MC--Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: Albert
authors.initials: A
authors.lastname: Wolkerstorfer
authors.forename: Huub F J
authors.initials: HF
authors.lastname: Savelkoul
authors.forename: Flora B
authors.initials: FB
authors.lastname: de Waard van der Spek
authors.forename: Herman J
authors.initials: HJ
authors.lastname: Neijens
authors.forename: Tim
authors.initials: T
authors.lastname: van Meurs
authors.forename: Arnold P
authors.initials: AP
authors.lastname: Oranje
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001249:Asthma / Q000097:blood / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood* / Q000628:therapy; D019040:E-Selectin / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007229:Infant Welfare; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D009779:Occlusive Dressings; D012135:Respiratory Sounds / Q000187:drug effects; D012720:Severity of Illness Index; D012995:Solubility; D013223:Statistics as Topic; D016896:Treatment Outcome; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D000305:Adrenal Cortex Hormones; D015415:Biomarkers; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1