Spectrophotometric determination of cimetidine in pharmaceuticals and urine using batch and flow-injection methods.
Two sensitive and fast spectrophotometric methods using batch and flow-injection procedures for the determination of cimetidine (CMT) are proposed. The methods are based on the formation of a green complex between this drug and Cu(II) in acetic/acetate medium of pH 5.9. The calibration graphs resulting from measuring the absorbance at 330 nm are linear over the ranges 2.5 x 10(-6)-1.0 x 10(-3) and 5 x 10(-6)-2.0 x 10(-3) M with detection limits of 9.5 x 10(-7) and 2.1 x 10(-6) for batch and flow-injection methods, respectively. The methods are applied to the routine analysis of CMT in pharmaceuticals and human urine.
Garcia
Ma Soledad
MS
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071 Murcia, Spain.
Albero
Ma Isabel
MI
Sánchez-Pedreño
Concepción
C
Abuherba
M S
MS
D002927:Cimetidine / Q000652:urine*; D017022:Flow Injection Analysis / Q000379:methods; D006801:Humans; D004364:Pharmaceutical Preparations / Q000652:urine; D013053:Spectrophotometry / Q000379:methods; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
D004364:Pharmaceutical Preparations; D013607:Tablets; D002927:Cimetidine