title: The effect of a micronutrient-fortified complementary food on micronutrient status, growth and development of 6- to 12-month-old disadvantaged urban South African infants.
abstract: The study was conducted to look at the effectiveness of a multimicronutrient-fortified complementary food on the micronutrient status, linear growth and psychomotor development of 6- to 12-month-old infants from a black urban disadvantaged community in the Western Cape, South Africa. The study was designed as an intervention study. In both the experimental and control groups, serum retinol concentration showed a decline over the intervention period of 6 months. The decline was less pronounced in the experimental group. This resulted in a significantly (P<005) higher serum retinol concentration at 12 months in the experimental group (26.8+/-5.8 microg/dl) compared with the control group (21.4+/-5 microg/dl). Serum iron concentration also declined over the intervention period. The decline was less pronounced in the experimental group. No difference was observed in haemoglobin levels between the groups at 12 months. Serum zinc concentration did not differ significantly between the two groups at follow up. Weight gain over the 6 months period did not differ significantly between the experimental (2.1+/-0.9 kg) and control groups (2.1+/-1.2 kg). There was no difference in linear growth between the experimental (10.0+/-1.5 cm) and control group (10.1+/-2.1 cm) at the end of the follow-up period. Weight and length at 6 months significantly predicted weight and length at 12 months. No difference was observed in psychomotor developmental scores between the two groups after 6 months of intervention. Introducing a multimicronutrient-fortified complementary food into the diet of 6- to 12-month-old infants seemed to have an arresting effect on declining serum retinol and iron concentration in the experimental group. No benefit was observed in serum zinc concentration, linear growth and psychomotor development.
authors.affiliation: Nutrition Intervention Research Unit, Medical Research Council of South Africa, PO Box 19070, Tygerberg 7505, South Africa. aoelofse@mrc.ac.za
authors.forename: A
authors.initials: A
authors.lastname: Oelofse
authors.forename: J M A
authors.initials: JM
authors.lastname: Van Raaij
authors.forename: A J S
authors.initials: AJ
authors.lastname: Benade
authors.forename: M A
authors.initials: MA
authors.lastname: Dhansay
authors.forename: J J M
authors.initials: JJ
authors.lastname: Tolboom
authors.forename: J G A J
authors.initials: JG
authors.lastname: Hautvast
mesh_terms: D002657:Child Development; D005260:Female; D005527:Food, Fortified; D006801:Humans; D007223:Infant; D007225:Infant Food; D007501:Iron / Q000097:blood; D018977:Micronutrients; D008895:Milk, Human; D009752:Nutritional Status; D011597:Psychomotor Performance; D013019:South Africa; D018709:Statistics, Nonparametric; D014505:Urban Population; D014801:Vitamin A / Q000097:blood
chemical_list: D018977:Micronutrients; D014801:Vitamin A; D007501:Iron