title: Undertreatment strongly decreases prognosis of breast cancer in elderly women.
abstract: OBJECTIVE
  No consensus exists on therapy of elderly cancer patients. Treatments are influenced by unclear standards and are usually less aggressive. This study aims to evaluate determinants and effect of treatment choice on breast cancer prognosis among elderly patients.
  
  
  METHODS
  We reviewed clinical files of 407 breast cancer patients aged >/= 80 years recorded at the Geneva Cancer Registry between 1989 and 1999. Patient and tumor characteristics, general health status, comorbidity, treatment, and cause of death were considered. We evaluated determinants of treatment by logistic regression and effect of treatment on mortality by Cox model, accounting for prognostic factors.
  
  
  RESULTS
  Age was independently linked to the type of treatment. Overall, 12% of women (n = 48) had no treatment, 32% (n = 132) received tamoxifen only, 7% (n = 28) had breast-conserving surgery only, 33% (n = 133) had mastectomy, 14% (n = 57) had breast-conserving surgery plus adjuvant therapy, and 2% (n = 9) received miscellaneous treatments. Five-year specific breast cancer survival was 46%, 51%, 82%, and 90% for women with no treatment, tamoxifen alone, mastectomy, and breast-conserving surgery plus adjuvant treatment, respectively. Compared with the nontreated group, the adjusted hazard ratio of breast cancer mortality was 0.4 (95% CI, 0.2 to 0.7) for tamoxifen alone, 0.4 (95% CI, 0.1 to 1.4) for breast-conserving surgery alone, 0.2 (95% CI, 0.1 to 0.7) for mastectomy, and 0.1 (95% CI, 0.03 to 0.4) for breast-conserving surgery plus adjuvant treatment.
  
  
  CONCLUSIONS
  Half of elderly patients with breast cancer are undertreated, with strongly decreased specific survival as a consequence. Treatments need to be adapted to the patient's health status, but also should offer the best chance of cure.
authors.affiliation: Geneva Cancer Registry, 55 Boulevard de la Cluse 55, 1205 Geneva, Switzerland. christine.bouchardymagnin@imsp.unige.ch.
authors.forename: Christine
authors.initials: C
authors.lastname: Bouchardy
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Rapiti
authors.forename: Gérald
authors.initials: G
authors.lastname: Fioretta
authors.forename: Paul
authors.initials: P
authors.lastname: Laissue
authors.forename: Isabelle
authors.initials: I
authors.lastname: Neyroud-Caspar
authors.forename: Peter
authors.initials: P
authors.lastname: Schäfer
authors.forename: John
authors.initials: J
authors.lastname: Kurtz
authors.forename: André-Pascal
authors.initials: AP
authors.lastname: Sappino
authors.forename: Georges
authors.initials: G
authors.lastname: Vlastos
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D010347:Patient Care Planning; D011379:Prognosis; D011787:Quality of Health Care; D018714:Radiotherapy, Adjuvant; D012044:Regression Analysis; D012189:Retrospective Studies