[Genetic variability of hepatitis C virus in the health area of Elche (Spain). Correlation between core antigen and viral load].
We investigated the prevalence of the various genotypes of hepatitis C virus (HCV) in 281 patients evaluated between March, 2000 and March, 2002 in the health area of Elche. Of these patients, 55 were coinfected with human immunodeficiency virus (HIV). The genotype was related to viral load and the co-existence of HIV infection. Likewise, the relationship between these parameters and the presence of the HCV core antigen was established. The results indicate that genotype 1b was the most prevalent (38.4%) followed by genotype 3a (23.1%). Patients coinfected with HIV presented fewer infections due to group 1 genotypes (p < 0.05).Patients with HIV presented a greater viral load in all the genotypes, with genotype 3 presenting a high viral load. Detection of the HCV core antigen showed a close correlation with viral load determinations. Although not yet sufficiently assessed, determination of the HCV core antigen constitutes a simple technique that could eventually contribute to improving the management of patients with chronic HCV hepatitis.
Rodríguez
J C
JC
Servicio de Microbiología. Hospital General Universitario de Elche. Universidad Miguel Hernández. Elche. Alicante. España. micro_elx@gva.es
García
J
J
Moya
I
I
Ayelo
A
A
Vázquez
N
N
Sillero
C
C
Royo
G
G
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000821:virology*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics* / Q000276:immunology; D006526:Hepatitis C / Q000453:epidemiology* / Q000821:virology*; D018937:Hepatitis C Antibodies / Q000097:blood; D018936:Hepatitis C Antigens / Q000097:blood; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood; D013030:Spain / Q000453:epidemiology; D019562:Viral Load
D018937:Hepatitis C Antibodies; D018936:Hepatitis C Antigens; D012367:RNA, Viral