title: Melatonin prevents free radical formation due to the interaction between beta-amyloid peptides and metal ions [Al(III), Zn(II), Cu(II), Mn(II), Fe(II)].
abstract: Alzheimer's disease, among other pathological features, is characterized by an over-accumulation of amyloid-beta peptide, metal ions, and oxidative stress proteins in the brain. Amyloid-beta aggregated peptides with bound metal ions may initiate free radical generation with consequent protein and lipid oxidation, reactive oxygen species formation and eventually neuronal death. Melatonin is able to dramatically reduce the free radical formation which follows the interaction between transition metal ions and amyloid-beta. This paper reports the scavenging effect of melatonin of reactants generated by amyloid peptides in combination with some metal ions.
authors.affiliation: CNR-Institute for Biomedical Technologies, Padova Unit Metalloproteins Department of Biology, University of Padova, Padova, Italy. zatta@mail.bio.unipd.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Zatta
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tognon
authors.forename: Paolo
authors.initials: P
authors.lastname: Carampin
mesh_terms: D016229:Amyloid beta-Peptides / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005609:Free Radicals / Q000378:metabolism*; D008550:Melatonin / Q000494:pharmacology*; D008670:Metals / Q000378:metabolism*; D008854:Microscopy, Electron; D010455:Peptides / Q000187:drug effects* / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016166:Free Radical Scavengers; D005609:Free Radicals; D008670:Metals; D010455:Peptides; D008550:Melatonin