Change of carbon monoxide in plasma and tissue during acute hypoxia.
OBJECTIVE
To investigate the role of endogenous carbon monoxide (CO) in hypoxia.


METHODS
After rats were inhaled with hypoxic gases and the heme oxygenase inhibitor ZnPPIX was administered, we measured the CO levels in plasma, liver, lung and kidney. Meanwhile plasma cGMP levels were observed. Furthermore, we recorded the change of hemodynamic and blood gases.


RESULTS
Acute mild hypoxia (10% O2) significantly increaed CO levels in plasma as well as liver, kidney and lung, while acute severe hypoxia (5% O2) significantly decreased CO levels in plasma as well as liver, kidney and lung. In addition, the former significantly elevated cGMP levels in plasma while the latter markedly reduced cGMP levels in plasma. The hemodynamic change occurred in accordance with the changes carbon monoxide.


CONCLUSIONS
Our results indicate, for the first time, that the endogenous carbon monoxide plays an important role in regulating the vessel tone during hypoxia.
Ding
Xueqin
X
Department of Anesthesiology and ICU, the First Affiliated Hospital, China Medical University, Shenyang 110001. xueqinding@yahoo.com
Liu
Guiming
G
Wang
Junke
J
Sheng
Zhuoren
Z
D000208:Acute Disease; D000818:Animals; D001784:Blood Gas Analysis; D002248:Carbon Monoxide / Q000097:blood / Q000378:metabolism*; D006152:Cyclic GMP / Q000097:blood; D006419:Heme Oxygenase (Decyclizing) / Q000037:antagonists & inhibitors; D006439:Hemodynamics; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D002248:Carbon Monoxide; D006419:Heme Oxygenase (Decyclizing); D006152:Cyclic GMP