title: [Intra-arterial thrombolysis in patients with acute ischemic stroke of the cervical internal carotid artery occlusive disease].
abstract: OBJECTIVE
  To observe the safety and efficacy of local intra-arterial thrombolysis (LIT) in patients with acute ischemic stroke of cervical internal carotid artery occlusive disease.
  
  
  METHODS
  10 patients were treated by LIT. 2 of 10 patients were further treated by either angioplasty or endarterectomy. Primary neuroradiological assessment was performed with CT in all patients. Angiographic recanalization level was classified according to thrombolysis in myocardial infarction (TIMI) grades. Clinical outcome was classified as good for Modified Rankin Scale (MRS) scores of 0 to 3 and as poor for MRS scores of 4 to 6.
  
  
  RESULTS
  Complete/partial recanalization after infusion was accomplished in 8 patients, seven of whom had good clinical outcome. Cerebral hemorrhage occurred in 2 of 10 patients.
  
  
  CONCLUSIONS
  The results of this study suggest that LIT may be helpful to improve the outcome in patients with acute cervical internal carotid artery occlusive disease if it is performed within 6 hours of stroke onset.
authors.affiliation: Department of Radiology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China. qingzhangs@yahoo.com.cn
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Zheng-yu
authors.initials: ZY
authors.lastname: Jin
authors.forename: Yi-ning
authors.initials: YN
authors.lastname: Huang
authors.forename: Wei-hai
authors.initials: WH
authors.lastname: Xu
authors.forename: Zu-yuan
authors.initials: ZY
authors.lastname: Ren
authors.forename: Chang-bao
authors.initials: CB
authors.lastname: Su
authors.forename: Ren-zhi
authors.initials: RZ
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Pan
authors.forename: Li-ying
authors.initials: LY
authors.lastname: Cui
authors.forename: Shan
authors.initials: S
authors.lastname: Gao
authors.forename: Jian
authors.initials: J
authors.lastname: Ye
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Dai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000188:drug therapy* / Q000209:etiology; D015912:Thrombolytic Therapy / Q000379:methods; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D014568:Urokinase-Type Plasminogen Activator