[Clinical and experimental studies on condyloma acuminata].
Condyloma acuminata(CA) is one of sexually transmitted diseases(STD) caused by human papillomavirus(HPV). We have done systemic study on the CA in recent years. Analyzing the morbidity of CA in our STD clinics showed that CA was in the first or second place of STD. Tissue specimens from CA were detected HPV DNA by dot blot hybridization and PCR. The result showed PCR was more sensitive than dot blot hybridization. HPV DNA were detected by PCR in tissue specimens of cervical squamous carcinoma, as well as cervical and vulvar CA. The result confirmed that HPV 16 was main type in cervical squamous carcinoma, and HPV 6 and 11 were main types in cervical and vulvar CA. To differentiate pseudocodyloma of vulva from CA, electron microscopy and HPV DNA detection were done. Certain ultrastructural changes were helpful, and detection of HPV DNA was better method in differentiating CA from pseudocondyloma. High purification of podophyllintoxin was studied and the effectiveness of podophyllintoxin was observed, compared to imported podophyllintoxin to treat CA, both cure rates were more than 80% after 3 week's therapy. Intralesional injection of different interferons for CA was effective.
Wang
J
J
Department of Dermatology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. wangjb@csc.pumch.ac.cn
Liu
Y
Y
Jin
H
H
Wang
B
B
Wang
H
H
D003218:Condylomata Acuminata / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use; D008297:Male; D027383:Papillomaviridae / Q000235:genetics; D011034:Podophyllotoxin / Q000627:therapeutic use; D016133:Polymerase Chain Reaction; D016896:Treatment Outcome
D004279:DNA, Viral; D007641:Keratolytic Agents; D011034:Podophyllotoxin