Coupling the cell cycle to cell growth.
In order to multiply, both prokaryotic and eukaryotic cells go through a series of events that are collectively called the cell cycle. However, DNA replication, mitosis and cell division may also be viewed as having their own, in principle independent, cycles, which are tied together by mechanisms extrinsic to the cell cycle--the checkpoints--that maintain the order of events. We propose that our understanding of cell-cycle regulation is enhanced by viewing each event individually, as an independently regulated process. The nature of the parameters that regulate cell-cycle events is discussed and, in particular, we argue that cell mass is not such a parameter.
Boye
Erik
E
Department of Cell Biology, Institute for Cancer Research, Montebello, Oslo, Norway. eboye@labmed.uio.no
Nordström
Kurt
K
D018929:Cell Culture Techniques; D002453:Cell Cycle / Q000235:genetics; D018797:Cell Cycle Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D002455:Cell Division; D004261:DNA Replication; D018816:Genes, cdc; D008938:Mitosis / Q000502:physiology
D018797:Cell Cycle Proteins