[Minor fatty acids of biological fluids of urogenital organs and their significance in the diagnosis of inflammatory processes].
Minor lipid components (less than 1%), not occurring in the cells of mammals, have been detected in the profile of fatty acids (FA) in urine and vaginal fluid in females, as well as in ejaculate in males, by the method of gas chromatography and mass spectrometry. Their origin is supposedly attributed to microorganisms colonizing urogenital organs under normal conditions and in infectious pathology. Minor FA in the biological fluids of the urogenital tract (UGT) in man are compared with the FA composition of pure microbial cultures. The statistical analysis of FA concentrations in 500 specimens of UGT biological fluids indicates that lipid markers of microbial origin (in UGT inflammatory diseases) have a range of quantitative changes exceeding the limits of values characteristic of healthy persons and in a number of cases correlate with the diagnosis of the disease or the results of the bacteriological study. The reliability of the interpretation of the results of the marker analysis is confirmed by the difference in the composition of UGT microorganisms under normal conditions and in pathology, correlation with the clinical picture of pathological deviations, a decrease (to zero or normal values) in the concentration of the markers of pathogens as the result of treatment with antibiotics, as well as by the adequate composition of UGT microorganisms, determined by the marker method in comparison with the cultural biochemical method.
Krymtseva
T A
TA
Academic Group of Acad. Med. Sci. Yu.F. Isakov, State Research Institute for Design of Biological Instruments, Moscow, Russia.
Osipov
G A
GA
Boĭko
N B
NB
Sokolov
Ia A
IaA
Demina
A M
AM
Radiushina
T V
TV
Osipov
D G
DG
D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology*; D015415:Biomarkers / Q000032:analysis; D002849:Chromatography, Gas; D005227:Fatty Acids / Q000032:analysis* / Q000302:isolation & purification / Q000652:urine; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis*; D008297:Male; D013058:Mass Spectrometry; D014566:Urogenital System / Q000378:metabolism* / Q000382:microbiology*
D015415:Biomarkers; D005227:Fatty Acids