Activity of superoxide dismutase and glutathione peroxidase in human semen in normozoospermia and spermatopathy.
The aim of the study was to assess the levels of antioxidative enzymes--superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the whole semen of men treated for infertility. The first group consisted of the patients with normozoospermia; the second--included the men with oligozoospermia. According to sperm motility, the patients were divided into the third group--motility higher than 50% and the fourth group--motility lower than 50%. The study showed that the levels of both enzymes were higher in men with oligozoospermia than those with normozoospermia. It was also found that the activities of SOD and GSH-Px were higher in men with low motility(< 50%) compared to high motility patients. The results confirm that the activity of superoxide dismutase and glutathione peroxidase is related to the parameters of human semen assessed according to the WHO standards.
Tkaczuk-Włach
Joanna
J
Department of Reproduction and Andrology, Medical University of Lublin, Department of Biochemistry, Faculty of Veterinary Medicine, Agricultural University of Lublin.
Kankofer
Marta
M
Jakiel
Grzegorz
G
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D004789:Enzyme Activation; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D007248:Infertility, Male / Q000145:classification / Q000201:enzymology*; D008297:Male; D012661:Semen / Q000201:enzymology*; D013076:Sperm Count; D013081:Sperm Motility / Q000502:physiology*; D013094:Spermatozoa / Q000145:classification* / Q000201:enzymology*; D013223:Statistics as Topic; D013482:Superoxide Dismutase / Q000378:metabolism*
D000975:Antioxidants; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase