[Somatostatin mRNA expression in hippocampus of diabetic rats model].
OBJECTIVE
To investigate the relationship between diabetes and somatostatin (SOM).


METHODS
We established a streptozocin-induced diabetic rats model and studied the changes of SOM mRNA in hippocampi of diabetic and normal rats by using in situ hybridication and computer image analysis. We studied the mechanism of chronic diabetes encephalopathy by observing the changes of somatostatin mRNA in the hippocampus of diabetic rats was studied.


RESULTS
The number, light density and average area of positive cells in dentate gyrus area of hippocampus in diabetes model were reduced significantly as compared with normal rats (P < 0.01).


CONCLUSIONS
A decline in SOM mRNA expression may play a role in chronic diabetes encephalopathy because of SOM effect in brain.
Zhang
Xiao-ming
XM
Institute of Cell Biology and Tissue Engineering, Medical College of Zhejiang University, Hangzhou 310006, China. zxm@zju.edu.cn
Zhu
Xi
X
Yuan
Zhang-gen
ZG
Yu
Jun
J
Zhou
Ji-lin
JL
D000818:Animals; D001927:Brain Diseases / Q000209:etiology / Q000378:metabolism; D018891:Dentate Gyrus / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000096:biosynthesis* / Q000235:genetics
D012333:RNA, Messenger; D013004:Somatostatin