A new Co(2)(CO8-mediated tandem [5 + 1]/[2 + 2 + 1]-cycloaddition reaction: a one-pot synthesis of tricyclic delta-lactones from cis-epoxy ene-ynes.
In the presence of Co2(CO)8 and CO, cis-epoxyalkynes bearing a tether olefin undergo a tandem [5 + 1]/[2 + 2 + 1]-cycloaddition to give tricyclic delta-lactones efficiently in a one-pot operation. The reaction mechanism is proposed to involve a cobalt-coordinated cyclic allene species.
Odedra
Arjan
A
Department of Chemistry, National Tsing-Hua University, Hsinchu, Taiwan, ROC.
Wu
Chang-Jung
CJ
Madhushaw
Reniguntala J
RJ
Wang
Su-Lein
SL
Liu
Rai-Shung
RS