Superinfecting microorganisms in patients under treatment with cyclosporin-A and its correlation to gingival overgrowth.
The aim of this study was to identify the presence of superinfecting microorganisms (Gram-negative enteric rods and Candida sp.) in heart transplant patients and correlate this with gingival overgrowth. Thirty patients (10 females, 20 males--mean age 45 years) were examined. All were under cyclosporin-A (CsA) therapy. Patients who had taken any antibiotics 3 months prior the study or had been submitted to periodontal therapy were not enrolled. Patients were required to have at least 6 teeth. The plaque index (PI), gingival index (GI), pocket depth (PD) and clinical attachment level (CAL) were recorded. Microbiological samples were taken from sulcus/pocket (s/p) and from stimulated saliva (ss) and submitted to analysis. Patients were divided into two groups: the ones with gingival overgrowth (GO) and those without gingival overgrowth (WGO). After statistical analysis (chi-square test, Student's t-test, Fisher test, p < or = 0.05), we concluded that there was no statistical difference between groups in the parameters of gender, CsA dosage, time since transplantation, PI, GI, PD and CAL. Gram-negative rods from either the sulcus/pocket or saliva samples were not found. Candida sp. was detected (s/p-30% and ss-30%). Stimulated saliva samples analysis determined that the presence of Candida sp. was associated with patients without gingival overgrowth.
Romito
Giuseppe Alexandre
GA
Department of Stomatology, School of Dentistry, University of São Paulo.
Lotufo
Roberto Fraga
RF
Saraiva
Luciana
L
Pustiglioni
Alessandro Nautili
AN
Pustiglioni
Francisco Emílio
FE
Stolf
Noedir Antônio
NA
D000293:Adolescent; D000328:Adult; D000368:Aged; D002176:Candida albicans / Q000302:isolation & purification; D016572:Cyclosporine / Q000009:adverse effects*; D003774:Dental Plaque Index; D005260:Female; D005881:Gingiva / Q000382:microbiology; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000382:microbiology; D005888:Gingival Pocket / Q000382:microbiology; D006090:Gram-Negative Bacteria / Q000302:isolation & purification*; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000382:microbiology*; D009061:Mouth Mucosa / Q000382:microbiology; D011183:Postoperative Complications / Q000382:microbiology
D007166:Immunosuppressive Agents; D016572:Cyclosporine