PRV-1 mRNA expression and other molecular markers in polycythemia rubra vera.
During the past 4 years, the first molecular markers for polycythemia vera (PV) have been described. These markers include decreased expression of the thrombopoietin receptor c-Mpl, increased expression of the surface receptor polycythemia rubra vera-I, and insulin-like growth factor-I hypersensitivity. Characterization of these abnormalities has allowed the development of the first molecular diagnostic tools for PV. However, despite these advances, the molecular mechanisms leading to the development of PV remain poorly understood. This review summarizes and evaluates recent advances in our understanding of molecular aberrations in PV.
Pahl
Heike L
HL
Division of Experimental Anaesthesiology, University Hospital Freiburg, Center for Clinical Research, Breisacher Street 66, 79106 Freiburg, Germany. pahl@uni-freiburg.de
D015415:Biomarkers; D058851:GPI-Linked Proteins; D015972:Gene Expression Regulation, Neoplastic; D006133:Growth Substances; D006801:Humans; D007519:Isoantigens; D008562:Membrane Glycoproteins; D011087:Polycythemia Vera / Q000235:genetics* / Q000473:pathology; D012333:RNA, Messenger / Q000096:biosynthesis; D011956:Receptors, Cell Surface / Q000235:genetics*
D015415:Biomarkers; C407242:CD177 protein, human; D058851:GPI-Linked Proteins; D006133:Growth Substances; D007519:Isoantigens; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface