[Fc receptors of endothelial cells of cardiac valves: comparison of IgG Fc binding activity of these receptors and of Fc receptors of group A streptococci].
Normal human and rabbit sera, as well as IgG isolated from them, have proved to be capable of reacting with the cells of the valve endothelium of the human and bovine heart. As shown in this study, these reactions are linked with the presence of Fc receptors on the epithelial cells. This is confirmed by the positive reactions of the endothelial cells with the Fc fragments of IgG, as well as with pure antibodies to egg albumin and to group A streptococcal polysaccharide and their complexes. As revealed in this study, Fc receptors on endothelial cells and staphylococcal Fc receptors bind with the definite fraction of normal human serum IgG with, probably, more pronounced cytophil properties. This fraction is not linked with IgG subclasses. The suggestion may be made that the presence of IgG Fc binding activity in group A streptococci, coinciding with the binding activity of Fc receptors in some cells of the human body, is probably of importance for pathogenic streptococci, facilitating their successful invasion.
Danilova
T A
TA
Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
D000818:Animals; D000906:Antibodies / Q000378:metabolism; D001665:Binding Sites; D002417:Cattle; D004730:Endothelium, Vascular / Q000276:immunology* / Q000378:metabolism; D006351:Heart Valves / Q000276:immunology*; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000378:metabolism; D011485:Protein Binding; D011817:Rabbits; D011961:Receptors, Fc / Q000276:immunology*; D017452:Receptors, IgG / Q000276:immunology; D013045:Species Specificity; D013297:Streptococcus pyogenes / Q000276:immunology
D000906:Antibodies; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D011135:Polysaccharides, Bacterial; D011961:Receptors, Fc; D017452:Receptors, IgG; C036112:streptococcal polysaccharide group A