[Survivin--a new tumor-specific anti-apoptosis factor].
Survivin (SVV) is a new member of IAP-family (inhibitor of apoptosis, IAP) proteins. It can inhibit apoptosis induced by a variety of factors, and plays important roles during mitosis and cytokinesis of cells. Studies indicated that it is a tumor-specific anti-apoptosis factor. Survivin is expressed during embryonal development but lacks expression in terminally differentiated adult tissues. Interestingly, it becomes reexpressed in transformed cell lines and in a variety of human tumors. Its overexpression is prognostic of tumors and is implicated in the resistance to chemotherapy of tumor cells. SVV may be a new and widely applicable target for gene- and protein-based therapy of tumors.
Guan
J
J
Department of Pathology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China. guanjianpumch@sina.com
Chen
J
J
D017209:Apoptosis / Q000502:physiology; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D009363:Neoplasm Proteins; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D000077022:Survivin
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin