title: [Expression of inducible nitric oxide synthase in human esophageal biopsies from carcinoma and precancerous lesions].
abstract: OBJECTIVE
  To investigate the possible role of inducible nitric oxide synthase (iNOS) in esophageal carcinogenesis.
  
  
  METHODS
  iNOS expressions in normal epithelial cells(NC), hyperplastic cells(HC), atypical hyperplastic cells(AHC) from grade I to III, carcinoma in situ(CIS), squamous cell carcinoma(SCC), and adenocarcinoma(ADC) were detected with immunohistochemistry.
  
  
  RESULTS
  The positive rates of immunohistochemistry staining was 0 for NC, 2.5% for HC, 4.0%, 7.5% and 2.5% for AHC grade I to III respectively, 1.4% for CIS, 8.5% for SCC and 71.4% for ADC.
  
  
  CONCLUSIONS
  There is a high expression of iNOS in human esophageal adenocarcinomas. Frequent expression of iNOS may be a potential event in ADC carcinogenesis. There is no correlation between iNOS and SCC carcinogenesis.
authors.affiliation: Detection Center of Tumor Biology, Cancer Institute, CAMS and PUMC, Beijing 100021, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Jin
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: B
authors.initials: B
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: Z
authors.initials: Z
authors.lastname: Han
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Jin
authors.forename: P
authors.initials: P
authors.lastname: Qu
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: Ding
authors.forename: P
authors.initials: P
authors.lastname: Lin
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology*; D004938:Esophageal Neoplasms / Q000201:enzymology*; D006801:Humans; D007150:Immunohistochemistry; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II; D011230:Precancerous Conditions / Q000201:enzymology*
chemical_list: C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II