[Non-diabetic renal disease in type II diabetes mellitus].
OBJECTIVE
Several studies have suggested that non-diabetic renal disease (NDRD) was common among non-insulin dependent diabetes mellitus (NIDDM) patients with renal involvement.


METHODS
The prevalence of NDRD among Chinese NIDDM population in PUMC hospital center was retrospectively studied. Renal biopsy specimens were evaluated with light-, immunofluorescence- and electron-microscopy. The cohort consisted of 33 NIDDM patients who received renal biopsy.


RESULTS
Patients with both isolated diabetic nephropathy (DN, n = 7) and NDRD (n = 22) had comparable duration of DM, creatinine clearance, serum creatinine, albumin and 24 hours proteinuria, as well as incidences of retinopathy, neuropathy and hypertension. Significantly more patients with NDRD had haematuria (P = 0.030) or non-nephrotic proteinuria (P = 0.016). IgA nephropathy accounted for 40.9% of the NDRD identified.


CONCLUSIONS
In this study, haematuria and non-nephrotic proteinuria predicted the presence of NDRD among NIDDM patients complicated with renal disease. IgA nephropathy is the most frequent type of NDRD in Chinese.
Li
Hang
H
Department of Nephropathy, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.
Li
Xue-wang
XW
Huang
Qing-yuan
QY
Ye
Wen-ling
WL
Duan
Lin
L
Li
Yan
Y
D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000473:pathology; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies