Therapy of neurological disorders in systemic vasculitis.
Significant progress has been made in our understanding of the underlying cellular and molecular mechanisms associated with vasculitis. Simultaneous involvement of the nervous system and systemic organs points to shared antigenic targets or immune mechanisms operative at both sites. Although specific immunotherapy is not available, the old and new immunomodulatory therapies have been instrumental in providing effective therapy in most of these chronic autoimmune disorders. The treatment of giant cell arteritis, neurosarcoidosis, Wegener's granulomatosis, systemic lupus erythematosus, polyarteritis, Sjögren's syndrome, and Behcet disease will be reviewed.
Gold
Ralf
R
Department of Neurology, Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Julius-Maximilians-Universität Würzburg, Josef-Schneider-Strasse 11, D-97080 Würzburg, Germany.
Fontana
Adriano
A
Zierz
Stephan
S
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D001528:Behcet Syndrome / Q000628:therapy; D013700:Giant Cell Arteritis / Q000628:therapy; D014890:Granulomatosis with Polyangiitis / Q000628:therapy; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008180:Lupus Erythematosus, Systemic / Q000628:therapy; D009422:Nervous System Diseases / Q000628:therapy*; D010488:Polyarteritis Nodosa / Q000628:therapy; D011111:Polymyalgia Rheumatica / Q000628:therapy; D012507:Sarcoidosis / Q000628:therapy; D012859:Sjogren's Syndrome / Q000628:therapy; D014657:Vasculitis / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*
D000276:Adjuvants, Immunologic