title: Regression of intracardiac heparin-induced thrombosis after aortic root surgery.
abstract: Heparin-induced thrombocytopenia and thrombosis syndrome (type II) is associated with thromboembolic complications and a mortality rate up to 30%. We describe a patient who developed intracardiac and aortic Dacron prosthesis heparin-induced thrombosis after aortic root conservative surgery. Successive transoesophageal echocardiographies demonstrated a progressive regression of intracardiac thrombosis with oral anticoagulation by warfarin and antiplatelet therapy combining aspirin and clopidogrel.
authors.affiliation: Department of Cardiac Surgery, Hôpital de la Timone, University of Marseille, Marseille, France. fcollart@univ-aix.fr
authors.forename: Frédéric
authors.initials: F
authors.lastname: Collart
authors.forename: David
authors.initials: D
authors.lastname: Derouck
authors.forename: Francois
authors.initials: F
authors.lastname: Kerbaul
authors.forename: Horea
authors.initials: H
authors.lastname: Feier
authors.forename: Thierry G
authors.initials: TG
authors.lastname: Mesana
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage*; D017545:Aortic Aneurysm, Thoracic / Q000000981:diagnostic imaging / Q000601:surgery; D001241:Aspirin / Q000008:administration & dosage; D001807:Blood Vessel Prosthesis; D000077144:Clopidogrel; D004359:Drug Therapy, Combination; D017548:Echocardiography, Transesophageal; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000139:chemically induced / Q000188:drug therapy*; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D018570:Risk Assessment; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy; D013927:Thrombosis / Q000139:chemically induced* / Q000188:drug therapy*; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D016896:Treatment Outcome; D014859:Warfarin / Q000008:administration & dosage
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D014859:Warfarin; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin