Chemical synthesis of novel taurine-containing uridine derivatives.
Recently, novel taurine-containing uridine derivatives were discovered in mammalian mitochondrial tRNAs, and these modified ribonucleosides existed at the first position of the anti-codon. This paper describes the chemical synthesis of these novel uridine derivatives, 5-taurinomethyluridine (tau m5U) and 5-taurinomethyl-2-thiouridine (tau m5s2U). These taurine-containing uridine derivatives were synthesized in the good yields by the reaction of the corresponding 5-hydroxymethyluridine derivatives with taurine under basic conditions.
Wada
Takeshi
T
Department of Integrated Biosciences, Graduate School of Frontier Science, University of Tokyo, Bioscience Bldg 702, Kashiwa, Chiba 277-8562, Japan.
Shimazaki
Tomomi
T
Nakagawa
Shingo
S
Otuki
Takashi
T
Kurata
Shinya
S
Suzuki
Tsutomu
T
Watanabe
Kimitsuna
K
Saigo
Kazuhiko
K
D002851:Chromatography, High Pressure Liquid; D019906:Nuclear Magnetic Resonance, Biomolecular; D013654:Taurine / Q000737:chemistry*; D014529:Uridine / Q000138:chemical synthesis* / Q000737:chemistry
D013654:Taurine; D014529:Uridine