System maps for retention of neutral organic compounds under isocratic conditions on a reversed-phase monolithic column.
The solvation parameter model is used to create systems maps for the separation of neutral organic compounds on a Chromolith Performance RP-18e octadecylsiloxane-bonded silica-based monolithic column for water-acetonitrile and water-methanol mobile phase compositions from 10 to 70% (v/v) organic solvent. These results demonstrate that the retention properties of the monolithic column are similar to those of conventional octadecylsiloxane-bonded silica particle-packed columns. It is further shown that the selectivity for the monolithic column falls within the selectivity range for typical particle-packed columns at two mobile phase compositions for which a direct comparison is possible.
Chu
Yun
Y
Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Poole
Colin F
CF
D000097:Acetonitriles; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D007202:Indicators and Reagents; D008433:Mathematics; D000432:Methanol; D008956:Models, Chemical; D009930:Organic Chemicals / Q000302:isolation & purification*; D012680:Sensitivity and Specificity; D012822:Silicon Dioxide; D012997:Solvents; D014867:Water
D000097:Acetonitriles; D007202:Indicators and Reagents; D009930:Organic Chemicals; D012997:Solvents; C026679:octadecylsilica; D014867:Water; D012822:Silicon Dioxide; D000432:Methanol; C032159:acetonitrile