title: Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants.
abstract: Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor. X-irradiation of a restricted region of mouse brain containing the hippocampus prevented the neurogenic and behavioral effects of two classes of antidepressants. These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus.
authors.affiliation: Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.
authors.forename: Luca
authors.initials: L
authors.lastname: Santarelli
authors.forename: Michael
authors.initials: M
authors.lastname: Saxe
authors.forename: Cornelius
authors.initials: C
authors.lastname: Gross
authors.forename: Alexandre
authors.initials: A
authors.lastname: Surget
authors.forename: Fortunato
authors.initials: F
authors.lastname: Battaglia
authors.forename: Stephanie
authors.initials: S
authors.lastname: Dulawa
authors.forename: Noelia
authors.initials: N
authors.lastname: Weisstaub
authors.forename: James
authors.initials: J
authors.lastname: Lee
authors.forename: Ronald
authors.initials: R
authors.lastname: Duman
authors.forename: Ottavio
authors.initials: O
authors.lastname: Arancio
authors.forename: Catherine
authors.initials: C
authors.lastname: Belzung
authors.forename: René
authors.initials: R
authors.lastname: Hen
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D003213:Conditioning, Psychological; D018891:Dentate Gyrus / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D005239:Fear; D005247:Feeding Behavior / Q000187:drug effects; D005473:Fluoxetine / Q000494:pharmacology*; D006120:Grooming / Q000187:drug effects; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D017774:Long-Term Potentiation / Q000528:radiation effects; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011985:Receptors, Serotonin / Q000235:genetics / Q000378:metabolism; D044263:Receptors, Serotonin, 5-HT1; D013312:Stress, Physiological / Q000188:drug therapy / Q000503:physiopathology; D009435:Synaptic Transmission / Q000528:radiation effects
chemical_list: D000928:Antidepressive Agents; D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D005473:Fluoxetine; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin