[Spectral properties of new photosensitizers for photodynamic diagnosis and therapy].
The spectral properties of new photosensitizer ZnPcS2P2, PsD-007 and HMME, as well as traditional photosensitizer HpD have been studied by comparing their spectra in physiological saline and in physiological saline with 10 percent serum. Experimental results show that the maximum absorption peaks for PsD-007, HMME and HpD in the physiological saline with 10 percent serum appear at 400 nm in the soret region, while at 670 nm for ZnPcS2P2. The fluorescence excitation spectra closely resemble the absorption spectra. When excited by the light at the wavelengths of 413 and 514.5 nm, the fluorescence emission peaks for PsD-007, HMME and HpD appear at 625 and 690 nm, respectively. The fluorescent excitation efficiency of the same photosensitizer with the same concentration excited by the light at the wavelength of 413 nm is about three fold higher than that at 514.5 nm. Furthermore, the fluorescent excitation efficiency is the highest for HMME, but is lower for HpD and lowest for PsD-007. These results are significant in the selection of photosensitizers for photodynamic diagnosis and therapy.
Li
Bu-hong
BH
National Research Center of Engineering and Technology for Optical Instrumentation, Zhejiang University, Hangzhou 310027, China.
Xie
Shu-sen
SS
Lu
Zu-kang
ZK
D017324:Hematoporphyrin Derivative / Q000737:chemistry* / Q000627:therapeutic use; D006414:Hematoporphyrin Photoradiation; D006415:Hematoporphyrins / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
D006415:Hematoporphyrins; D017319:Photosensitizing Agents; D017324:Hematoporphyrin Derivative