Regulation of plasma membrane H+-ATPase activity by the membrane environment.
The plant plasma membrane H(+)-ATPase is a proton pump which plays a central role in physiological functions such as nutrient uptake and intracellular pH regulation. This pump belongs to the P(3)-type ATPase family and creates an electrochemical gradient across the plasma membrane. The generation of this gradient has a major role in providing the energy for secondary active transport across the plasma membrane. The activity of the proton pump is regulated by the transcriptional and post-translational levels and by membrane environmental factors such as membrane lipids. Several reviews have appeared during the last few years concerning the regulatory mechanism at transcriptional and post-translational levels. The plasma membrane H(+)-ATPase requires lipids for activity. This lipid dependency suggests a possible mode of regulation of the H(+)-ATPase via modification of its lipid environment. This review focuses on the regulation of plasma membrane H(+)-ATPase by membrane lipids surrounding H(+)-ATPase molecules.
Kasamo
Kunihiro
K
Research Institute for Bioresources, Okayama University, Kurashiki, Okayama 710-0046, Japan. hn@rib.okayama-u.ac.jp
D000595:Amino Acid Sequence; D002462:Cell Membrane / Q000201:enzymology* / Q000502:physiology; D017124:Conserved Sequence; D004563:Electrochemistry; D004789:Enzyme Activation / Q000187:drug effects; D008081:Liposomes / Q000378:metabolism; D008958:Models, Molecular; D012275:Oryza / Q000201:enzymology* / Q000235:genetics; D010743:Phospholipids / Q000494:pharmacology; D011487:Protein Conformation; D006180:Proton-Translocating ATPases / Q000145:classification / Q000235:genetics / Q000378:metabolism*
D008081:Liposomes; D010743:Phospholipids; D006180:Proton-Translocating ATPases