Antigen presentation to naive CD4 T cells in the lymph node.
Although the presentation of peptide-major histocompatibility complex class II (pMHC class II) complexes to CD4 T cells has been studied extensively in vitro, knowledge of this process in vivo is limited. Unlike the in vitro situation, antigen presentation in vivo takes place within a complex microenvironment in which the movements of antigens, antigen-presenting cells (APCs) and T cells are governed by anatomic constraints. Here we review developments in the areas of lymph node architecture, APC subsets and T cell activation that have shed light on how antigen presentation occurs in the lymph nodes.
Itano
Andrea A
AA
Department of Microbiology and the Center for Immunology, University of Minnesota, MMC 334, 420 Delaware St. SE, Minneapolis, Minnesota 55455, USA.
Jenkins
Marc K
MK
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000938:Antigen-Presenting Cells / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology*
D000949:Histocompatibility Antigens Class II