Photolysis of diacyl peroxides: a radical-based approach for the synthesis of functionalized amino acids.
[reaction: see text] Photolysis of the amino acid derived symmetrical and unsymmetrical diacyl peroxides at 254 nm at low temperature (-78 to -196 degrees C) generates various bis(amino acids) in a concise manner and with orthogonal protection. The methodology was applied to the synthesis of (4R)-5-propyl-L-leucine (PrLeu), a component of HUN-7293.
Spantulescu
M Daniel
MD
Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2.
Jain
Rajendra P
RP
Derksen
Darren J
DJ
Vederas
John C
JC
D000596:Amino Acids / Q000138:chemical synthesis*; D010545:Peroxides / Q000737:chemistry*; D010782:Photolysis
D000596:Amino Acids; D010545:Peroxides