Apolipoprotein E genotype and temperament: a longitudinal study from infancy to the late teens.
OBJECTIVE
To replicate an earlier Finnish study by Keltikangas-Järvinen et al. (5) reporting that the APOE genotype is associated with temperamental traits involving increased activity.


METHODS
DNA was collected from 683 Australian children who had participated in a longitudinal study of childhood temperament from 4 to 8 months up to 17 to 18 years. Associations were examined between APOE genotype and a range of measures of activity and hyperactivity.


RESULTS
No associations were found.


CONCLUSIONS
The earlier Finnish finding could not be replicated despite adequate statistical power.
Jorm
Anthony F
AF
Centre for Mental Health Research, Australian National University, Canberra, ACT, Australia. Anthony.Jorm@anu.edu.au
Prior
Margot
M
Sanson
Ann
A
Smart
Diana
D
Zhang
Yafei
Y
Easteal
Simon
S
D000293:Adolescent; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D001315:Australia; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004247:DNA / Q000235:genetics; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005387:Finland; D005838:Genotype; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D010551:Personality / Q000235:genetics*; D013694:Temperament / Q000502:physiology*; D044465:White People / Q000235:genetics
D001057:Apolipoproteins E; D004247:DNA