Receptor-ligand binding: 'catch' bonds finally caught.
Leukocyte recruitment to sites of inflammation is initiated by the selectin family of adhesion receptors. Recent research reveals that P-selectin binding to its ligand exhibits 'catch' to 'slip' bond transition that may help explain the shear threshold phenomenon.
Konstantopoulos
Konstantinos
K
Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.
Hanley
William D
WD
Wirtz
Denis
D
D002448:Cell Adhesion; D008024:Ligands; D008562:Membrane Glycoproteins / Q000378:metabolism; D008958:Models, Molecular; D019007:P-Selectin / Q000378:metabolism*; D016028:Receptors, Leukocyte-Adhesion / Q000378:metabolism*; D033081:Shear Strength
D008024:Ligands; D008562:Membrane Glycoproteins; D019007:P-Selectin; C084882:P-selectin ligand protein; D016028:Receptors, Leukocyte-Adhesion