Stereospecific total synthesis of the antiviral agent hamigeran B--use of large silyl groups to enforce facial selectivity and to suppress hydrogenolysis.
Clive
Derrick L J
DL
Chemistry Department, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada. derrick.clive@ualberta.ca
Wang
Jian
J
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D006865:Hydrogenation; D008956:Models, Chemical; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry; D012825:Silicon / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D009285:Naphthoquinones; C483756:hamigeran B; D012825:Silicon