title: High dose of tranexamic acid for treatment of severe menorrhagia in patients with von Willebrand disease.
abstract: Menorrhagia is one of the most important and frequent complications in women with congenital von Willebrand disease (vWD). Three cases of menorrhagia with vWD (type 1; 1 case, type 2A; 2 cases) were successfully treated with tranexamic acid at dose of 3 grams daily in four divided doses for the first 5 days of the menstrual cycle. All patients had severe menorrhagia lasted for more than 10 days with iron deficiency anemia of hemoglobin levels of 6.5-8.4 g/dl. Common dosage of tranexamic acid of 1 gram daily in 4 divided doses on days 1-5 of their menstrual cycles did not correct their menorrhagia. The treatment was then changed to the daily dose of 3 grams in 4 divided doses on days 1-5 of their menstrual cycles. Thereafter, their menorrhagia became well-controlled with improvement of their anemia up to hemoglobin of 11.5-12.4 g/dl. High dose of tranexamic acid has been administered safely in all patients for 3-5 years without significant complications. Oral high-dose administration of tranexamic acid is very convenient and useful for treatment of menorrhagia in the patients with vWD.
authors.affiliation: Health Promotion Service, Tokai University School of Medicine Bouseidai, Isehara City 259-1193, Japan. mohrih@is.icc.u-tokai.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mohri
mesh_terms: D000284:Administration, Oral; D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008595:Menorrhagia / Q000150:complications / Q000188:drug therapy*; D014148:Tranexamic Acid / Q000008:administration & dosage*; D014842:von Willebrand Diseases / Q000150:complications / Q000188:drug therapy*
chemical_list: D014148:Tranexamic Acid