title: Aporphine alkaloids from Guatteria spp. with leishmanicidal activity.
abstract: Fractionation of Guatteria amplifolia yielded the alkaloids xylopine (1), nornuciferine (4), lysicamine (6), and laudanosine (5). Fractionation of Guatteria dumetorum yielded the alkaloids cryptodorine (2) and nornantenine (3). Compounds 1-4 demonstrated significant activity against Leishmania mexicana and L. panamensis. Xylopine (1) was among the most active compounds (LD 50 = 3 microM) and showed a 37-fold higher toxicity towards L. mexicana than macrophages, the regular host cells of Leishmania spp.
authors.forename: Hector
authors.initials: H
authors.lastname: Montenegro
authors.forename: Marcelino
authors.initials: M
authors.lastname: Gutiérrez
authors.forename: Luz I
authors.initials: LI
authors.lastname: Romero
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ortega-Barría
authors.forename: Todd L
authors.initials: TL
authors.lastname: Capson
authors.forename: Luis Cubilla
authors.initials: LC
authors.lastname: Rios
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D031043:Guatteria / Q000737:chemistry*; D006801:Humans; D007891:Leishmania / Q000187:drug effects*; D007894:Leishmania mexicana / Q000187:drug effects*
chemical_list: D000470:Alkaloids