title: The X-ray crystallographic study of long chain left handed Z-DNA and polyamine complex and structural chemistry study of effection by polyamine for the Z-DNA.
abstract: We cleared the stabilization mechanism of Z-DNA by using the molecular dynamics calculation and the grid map simulated annealing docking method. Then, we clarified Z-DNA was stabilized by the metal counter ions whose electrical charge and the number of electrons are too many and by polyamine to go into the minor groove. We succeeded in stabilizing Z-DNA of the long chain by using these methods, and succeeded in the crystallization and the data collection up to 1.7 A resolution.
authors.affiliation: Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Ohishi
authors.forename: Kenji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Grzeskowiak
authors.forename: Keiichi
authors.initials: K
authors.lastname: Fukuyama
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Ishida
mesh_terms: D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*
chemical_list: D011073:Polyamines; D004247:DNA