[Cardiovascular consequences of obstructive sleep apnea syndrome].
OBJECTIVE
This article is an update of past and current data on the relationship between obstructive sleep apnea syndrome and cardiovascular diseases.


BACKGROUND
Obstructive sleep apnea syndrome is a common, but under-recognised, condition and should not be considered simplistically as the association of snoring and obesity. It may be suspected by the clinical history but a definite diagnosis requires the practice of polysomnography. Numerous studies have found a significant relationship between the presence of obstructive sleep apnea syndrome and the occurrence of cardiovascular events. Nonetheless, a definite causal relationship has only been established for the occurrence of hypertension. There are multiple immediate and delayed cardiovascular responses to the apneic events and thus there are many possible physiopathological mechanisms to explain the association of obstructive sleep apnea and cardiac and vascular events, the primary one being sympathetic hyperactivity. The prognosis of obstructive sleep apnea syndrome is closely related to the incidence of cardiovascular events. FUTURE PROSPECTS AND PROJECS: The existence of an independent relationship between obstructive sleep apnea syndrome and atherosclerosis is not yet demonstrated. The beneficial effects of continuous positive airway pressure, the treatment of choice for this condition, on the incidence of cardiovascular diseases remains to be confirmed although recent studies suggest that correct treatment of obstructive sleep apnea syndrome by continuous positive airway pressure may reduce the cardiovascular risk and in particular that of hypertension.
Baguet
J-P
JP
Service de cardiologie et hypertension artérielle, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France. JPBaguet@chu-grenoble.fr
Pépin
J-L
JL
Hammer
L
L
Lévy
P
P
Mallion
J-M
JM
D001161:Arteriosclerosis / Q000150:complications / Q000209:etiology; D002318:Cardiovascular Diseases / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000209:etiology; D011379:Prognosis; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications*