[Clinical value of induced sputum test in monitoring airway inflammation in asthma].
OBJECTIVE
To explore the clinical value of induced sputum test in monitoring airway inflammation in asthmatic patients.


METHODS
The induced sputum test was done in 12 normal subjects and 21 asthmatic subjects; The levels of interleukin-8 (IL-8), eosinophil cation protein (ECP), malondialdehyde (MDA) in plasma and induced sputum in all subjects were measured.


RESULTS
The levels of IL-8, ECP, MDA in plasma and induced sputum in unstable asthmatic patients were significantly higher than those in stable asthmatic (P < 0.01), in which the levels of IL-8, ECP, MDA in both plasma and induced sputum were significantly higher than those in normal subjects(P < 0.05); In all asthmatic patients, the levels of IL-8, ECP, MDA in induced sputum were significantly higher than those in plasma.


CONCLUSIONS
The levels of IL-8, ECP, MDA in induced sputum could be used for monitoring airway inflammation in asthmatic patients.
Zhang
H B
HB
Department of Respiratory Diseases, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.
Lin
Y G
YG
Zhao
X M
XM
D000328:Adult; D001249:Asthma / Q000378:metabolism / Q000473:pathology*; D001798:Blood Proteins / Q000032:analysis; D001980:Bronchi / Q000378:metabolism*; D047091:Eosinophil Granule Proteins; D006801:Humans; D007249:Inflammation; D016209:Interleukin-8 / Q000032:analysis; D008315:Malondialdehyde / Q000032:analysis; D012260:Ribonucleases / Q000032:analysis; D013183:Sputum / Q000737:chemistry*
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D016209:Interleukin-8; D008315:Malondialdehyde; D012260:Ribonucleases