title: Multi-pumping flow system for the spectrophotometric determination of dipyrone in pharmaceutical preparations.
abstract: A novel flow system for the spectrophotometric determination of dipyrone with p-dimethylaminobenzaldehyde exploiting the multi-pumping approach was developed. The proposed methodology utilises several micro-pumps for propelling the involved fluids under improved mixing conditions, introducing sample/reagent aliquots and providing commuting facilities. As a consequence the multi-pumping system presents high versatility and manifold simplicity, as well as a straightforward operational control and enhanced analytical capabilities. Linearity of the analytical curve was observed within 10 and 400 mg l(-1) dipyrone (r=0.9997; n=6), results were precise (r.s.d.<0.12%; n=20) and sampling rate was 50 h(-1). Detection limit was estimated as 1 mg l(-1) dipyrone. The method was applied to pharmaceutical preparations and the results were in agreement with those obtained by the reference procedure with relative deviations within -1.7 and +2.2%.
authors.affiliation: REQUIMTE/Departamento det Química-Fisica, Faculdade de Farmácia, Universidade do Porto, Rua Anibal Cunha 164, 4050 Porto, Portugal.
authors.forename: José L F C
authors.initials: JL
authors.lastname: Lima
authors.forename: Sandra M
authors.initials: SM
authors.lastname: Oliveira Sá
authors.forename: João L M
authors.initials: JL
authors.lastname: Santos
authors.forename: Elias A G
authors.initials: EA
authors.lastname: Zagatto
mesh_terms: D004177:Dipyrone / Q000032:analysis* / Q000737:chemistry; D004304:Dosage Forms; D017022:Flow Injection Analysis / Q000379:methods; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004304:Dosage Forms; D004364:Pharmaceutical Preparations; D004177:Dipyrone