Chronic hepatitis C: modern notions of pathogenesis and morphogenesis. Concept of antiviral protection in hepatocytes.
Here we review modern notions about biological properties of hepatitis C virus, geographic distribution of its genotypes, peculiarities of immune reactions during chronic HCV infection, and role of viral replication in the infectious process. The concept of antiviral protection in liver parenchymal cells suggests suppression of biosynthetic reactions in hepatocytes resulting in inhibition of viral replication and focal degradation of the cytoplasm in infected cells followed by exocytosis and elimination of viral particles (cytosanation without cytodestruction). The recovery of structural characteristics in hepatocytes is associated with intracellular regeneration. Special accent is placed on reversibility of liver fibrosis in chronic HCV infection due to resorption of collagen fibers by hepatocytes. These data indicate that the therapy of liver fibrosis holds much promise.
Pokrovskii
V I
VI
Central Research Institute of Epidemiology, Russian Ministry of Health, Moscow.
Nepomnyashchikh
G I
GI
Tolokonskaya
N P
NP
D005355:Fibrosis / Q000473:pathology; D016174:Hepacivirus / Q000235:genetics / Q000378:metabolism; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000276:immunology; D022781:Hepatocytes / Q000378:metabolism*; D006801:Humans; D007107:Immune System / Q000502:physiology; D008099:Liver / Q000166:cytology / Q000473:pathology / Q000821:virology; D008115:Liver Regeneration / Q000502:physiology; D012189:Retrospective Studies; D014779:Virus Replication