Transplantation in Parkinson's disease: PET changes correlate with the amount of grafted tissue.
We compared the striatal uptake of [(18)F]fluorodopa with [(76)Br]-FE-CBT, a positron emission tomography (PET) ligand of the dopamine transporter (DAT), which estimates the density of dopamine nerve terminals, in 6 patients with Parkinson's disease grafted with fetal mesencephalic cells. There was no change in DAT ligand binding in the grafted putamen, despite a significant increase of [(18)F]fluorodopa uptake. This finding suggests that the clinical benefit induced by the graft is more related to increased dopaminergic activity than improved dopaminergic innervation in the host striatum and, therefore, that [(18)F]fluorodopa remains the optimal tracer to evaluate grafted PD patients. Further analysis showed that the clinical and [(18)F]fluorodopa uptake changes after the grafts were correlated with the number of ventral mesencephalae used for implantation.
Cochen
Valérie
V
Unité de Recherche Associée Commissariat à l'Energie Atomique (CEA)-Centre National de la Recherche Scientifique (CNRS) 2210, Orsay, France.
Ribeiro
Maria-Joao
MJ
Nguyen
Jean-Paul
JP
Gurruchaga
Jean-Marc
JM
Villafane
Gabriel
G
Loc'h
Christian
C
Defer
Gilles
G
Samson
Yves
Y
Peschanski
Marc
M
Hantraye
Philippe
P
Cesaro
Pierre
P
Remy
Philippe
P
D000368:Aged; D003342:Corpus Striatum / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D016332:Fetal Tissue Transplantation / Q000379:methods; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000378:metabolism; D008636:Mesencephalon / Q000196:embryology / Q000378:metabolism* / Q000637:transplantation*; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D010300:Parkinson Disease / Q000175:diagnosis* / Q000601:surgery*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D014055:Tomography, Emission-Computed
D050483:Dopamine Plasma Membrane Transport Proteins; D007166:Immunosuppressive Agents; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals; C493214:SLC6A3 protein, human; D019788:Fluorodeoxyglucose F18