title: Gender differences in cardiovascular risk factors.
abstract: Coronary heart disease is less common in premenopausal women compared to age-matched men. This difference disappears in the post-fertile years, and is presumably related to the reduced levels of female sex hormones, with subsequent metabolic and hemodynamic modifications. Ovarian exhaustion induces a more atherogenic lipid profile, which may partly explain the increased risk of cardiovascular disease observed in post-fertile women as compared to age-matched fertile women. After the menopause, the combination of aging and estrogen deficiency negatively affects glucose metabolism. Diabetes mellitus blunts the beneficial condition associated with the female gender; furthermore, it increases the incidence of myocardial infarction, claudication and stroke in women more than in men. Finally, the unfavorable effects of menopause on the coronary risk seem to be mediated partly by changes in clotting and fibrinolytic factors.
authors.affiliation: Department of Cardiovascular Sciences, University of Cagliari, Cagliari, Italy. mercuro@pacs.unica.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mercuro
authors.forename: Sandra
authors.initials: S
authors.lastname: Zoncu
authors.forename: Francesco
authors.initials: F
authors.lastname: Dragoni
mesh_terms: D001779:Blood Coagulation Factors / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology*; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008593:Menopause / Q000502:physiology; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D001779:Blood Coagulation Factors; D012739:Gonadal Steroid Hormones