Making proteins into drugs: assisted delivery of proteins and peptides into living neurons.
The introduction of exogenous proteins and peptides into cells is a valuable experimental approach. However, exogenous proteins are not internalized by living cells readily. This limitation has been overcome by the development of peptide-based methods that assist in the delivery of exogenous proteins into the cytoplasm and nucleus. These methods may facilitate the in vivo delivery of reagents in therapies aimed at neurodegenerative disorders and recovery from nervous system injury.
Gallo
Gianluca
G
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA.
D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D004705:Endocytosis / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology*; D011485:Protein Binding / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000502:physiology; D021381:Protein Transport / Q000502:physiology*; D011506:Proteins / Q000494:pharmacology*
D010455:Peptides; D011506:Proteins