title: Spectrophotometric determination of cimetidine in pharmaceuticals and urine using batch and flow-injection methods.
abstract: Two sensitive and fast spectrophotometric methods using batch and flow-injection procedures for the determination of cimetidine (CMT) are proposed. The methods are based on the formation of a green complex between this drug and Cu(II) in acetic/acetate medium of pH 5.9. The calibration graphs resulting from measuring the absorbance at 330 nm are linear over the ranges 2.5 x 10(-6)-1.0 x 10(-3) and 5 x 10(-6)-2.0 x 10(-3) M with detection limits of 9.5 x 10(-7) and 2.1 x 10(-6) for batch and flow-injection methods, respectively. The methods are applied to the routine analysis of CMT in pharmaceuticals and human urine.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071 Murcia, Spain.
authors.forename: Ma Soledad
authors.initials: MS
authors.lastname: Garcia
authors.forename: Ma Isabel
authors.initials: MI
authors.lastname: Albero
authors.forename: Concepción
authors.initials: C
authors.lastname: Sánchez-Pedreño
authors.forename: M S
authors.initials: MS
authors.lastname: Abuherba
mesh_terms: D002927:Cimetidine / Q000652:urine*; D017022:Flow Injection Analysis / Q000379:methods; D006801:Humans; D004364:Pharmaceutical Preparations / Q000652:urine; D013053:Spectrophotometry / Q000379:methods; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations; D013607:Tablets; D002927:Cimetidine