title: [Toxicity study of epidermal growth factor eye medicine liquid].
abstract: OBJECTIVE
  To apply for a new medicine certificate, the experiments of acute, long toxicity and side effects of EGF eye medicine liquid were investigated in animals.
  
  
  METHODS
  All of examinations were done according to the instructions of "Requirements of the Toxicity Study of New Medicine"
  
  
  RESULTS
  No toxicity or side-effect of EGF eye medicine liquid given by i.v., i.p., s.c. or eye-drop were been found.
  
  
  CONCLUSIONS
  For the results of whole experiments are in complete accord with "the requirements of the toxicity study of new medicine", EGF eye medicine liquid will be safety in clinical application.
authors.affiliation: Department of Pharmacology, Institute of Basic Medical Sciences, CAMS, PUMC, Beijing 100005, China. wanping@hns.cifh.ac.cn
authors.forename: Y X
authors.initials: YX
authors.lastname: Ye
authors.forename: B R
authors.initials: BR
authors.lastname: Huang
authors.forename: D H
authors.initials: DH
authors.lastname: Mo
mesh_terms: D000818:Animals; D004815:Epidermal Growth Factor / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D009883:Ophthalmic Solutions; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000633:toxicity; D018675:Toxicity Tests
chemical_list: D009883:Ophthalmic Solutions; D011994:Recombinant Proteins; D004815:Epidermal Growth Factor