Diffuse bone marrow involvement of Hodgkin lymphoma mimics hematopoietic cytokine-mediated FDG uptake on FDG PET imaging.
Whole-body fluorine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET) has been useful in the management of a variety of malignancies. In patients with chemotherapy followed by bone marrow stimulants such as granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor, the bone marrow will have diffuse, increased FDG accumulation. Therefore, diffuse bone marrow FDG uptake is commonly attributable to the effect of hematopoietic cytokines. However, diffuse bone marrow FDG uptake can also be caused by bone marrow involvement by malignancy. The authors report a patient with diffuse bone marrow involvement of Hodgkin disease that appears indistinguishable from hematopoietic cytokine-mediated FDG bone marrow uptake.
Chiang
Stephen B
SB
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Rebenstock
Alan
A
Guan
Liang
L
Alavi
Abass
A
Zhuang
Hongming
H
D000293:Adolescent; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism; D019046:Bone Marrow Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D016207:Cytokines / Q000008:administration & dosage*; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006410:Hematopoiesis / Q000187:drug effects; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014055:Tomography, Emission-Computed / Q000379:methods
D016207:Cytokines; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18