Topical inhibition of oral carcinoma cell with polymer delivered celecoxib.
Celecoxib has a potential role for oral cancer chemoprevention but its systemic side effects are a concern. Topical chemoprevention is a promising way to reduce the toxicity. This study was designed to determine whether topical application of polymer delivered celecoxib would have an inhibitory effect on human oral carcinoma cells. Seventeen nude mice were intradermally inoculated with the carcinoma cells, and then were divided into control and treatment groups. Tumor growth was measured for 15 days, at which significant difference was found between two groups (P<0.001). This study indicates a potential role of polymer film delivered celecoxib for topical inhibition of oral cancer.
Wang
Zhi
Z
Department of Otolaryngology, Head and Neck Surgery, Boston Medical Center, Boston University School of Medicine, D616, 88 East Newton Street, Boston, MA 02118, USA. zwang@bu.edu
Polavaram
Raju
R
Shapshay
Stanley M
SM
D000284:Administration, Oral; D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009062:Mouth Neoplasms / Q000517:prevention & control*; D009368:Neoplasm Transplantation; D011108:Polymers / Q000008:administration & dosage; D011720:Pyrazoles; D013449:Sulfonamides / Q000008:administration & dosage* / Q000627:therapeutic use; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
D016588:Anticarcinogenic Agents; D016861:Cyclooxygenase Inhibitors; D011108:Polymers; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib