Moonlighting proteins: old proteins learning new tricks.
Recently, several laboratories identifying proteins involved in the complex processes of replication, transcription and tumor suppression found that the 'new' protein they discovered had another, previously identified, function. A single protein with multiple functions might seem surprising, but there are actually many cases of proteins that 'moonlight', or have more than one role in an organism. As well as adding to the number and types of proteins that are known to moonlight, these new examples add to our understanding of the potential importance of moonlighting proteins.
Jeffery
Constance J
CJ
Laboratory for Molecular Biology, MC567, Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA. cjeffrey@uic.edu
D000818:Animals; D003546:Cysteine Endopeptidases / Q000235:genetics* / Q000378:metabolism; D004261:DNA Replication / Q000235:genetics / Q000502:physiology; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D009097:Multienzyme Complexes / Q000235:genetics* / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism
D029721:Drosophila Proteins; D009097:Multienzyme Complexes; D025521:Tumor Suppressor Proteins; C069204:crn protein, Drosophila; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex