title: Autologous recovery with protractedly undetectable donor chimerisms can precede stable donor engraftment in a nonmyeloablative cord blood transplant.
abstract: Low levels of donor chimerism on day 28 after hematopoietic stem cell transplantation are highly predictive of a subsequent rejection of donor cells A recent report on nonmyeloablative transplants has demonstrated that patients who engrafted after transplantation had at least 10% donor cells detectable at this time point. A patient is described who received a nonmyeloablative umbilical cord blood transplant and experienced subsequent full engraftment of donor cells despite the absence of donor chimerism at 4 weeks posttransplantation.
authors.affiliation: Department of Haematology, Singapore General Hospital, Singapore, Republic of Singapore. ghehyk@sgh.com.sg
authors.forename: William Hwang Ying
authors.initials: WH
authors.lastname: Khee
authors.forename: Patrick Tan Huat
authors.initials: PT
authors.lastname: Chye
authors.forename: Tan Cheng
authors.initials: TC
authors.lastname: Hoe
authors.forename: How Gee
authors.initials: HG
authors.lastname: Fung
authors.forename: Heng Khee
authors.initials: HK
authors.lastname: Khiang
authors.forename: Goh Yeow
authors.initials: GY
authors.lastname: Tee
mesh_terms: D000328:Adult; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D006085:Graft Survival; D006801:Humans; D008297:Male; D013997:Time Factors; D018183:Transplantation Chimera; D019172:Transplantation Conditioning / Q000379:methods; D014182:Transplantation, Autologous