title: Solution structure of the DNA complexes with an alkyl-linked bis(benzimidazole) compound, 1,4-bis[5-(4-methyl-1-piperazinyl)-2-benzimidazolyl]butane.
abstract: Solution structures of the 1:1 complexes of an alkyl-linked bis(benzimidazole) compound (4; Figure 1(a)) with the self-complementary DNA duplexes, d(CGCGAATTCGCG)2 and d(CGCAAATTTGCG)2, have been studied by 1H NMR spectroscopy and molecular mechanics calculations. The intermolecular NOE data and the energy-minimized geometries of the 1:1 complexes indicate that 4 binds in the minor groove of the 5'-GAATTCG and 5'-CAAATTT regions of the DNA duplexes.
authors.affiliation: Department of Chemistry, Faculty of Science, Yamaguchi University, Yamaguchi 753-8512, Japan.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Seiji
authors.initials: S
authors.lastname: Tani
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kubota
mesh_terms: D001483:Base Sequence; D001562:Benzimidazoles / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D011487:Protein Conformation; D012996:Solutions
chemical_list: C476815:1,4-bis(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)butane; D001562:Benzimidazoles; D012996:Solutions; D004247:DNA