[Studies on the relationship between D6S1581, a high frequency allele imbalance locus, and genetic susceptibility to nasopharyngeal carcinoma].
OBJECTIVE
To investigate the relationship of nasopharyngeal carcinoma (NPC) with the high frequency allele imbalance locus D6S1581, and the NPC associated gene FBXO30 which is located near D6S1581.


METHODS
Genescan was used to genotype D6S1581 of 12 NPC pedigrees, 85 sporadic NPC patients and 181 normal volunteers. Then parametric/nonparametric linkage analysis and association analysis were performed.


RESULTS
D6S1581 was linked with NPC, a Lod score of 2.611436 (P=0.00245) was obtained, and a significant difference in allele frequency was observed between familial NPC and control (P<0.005).


CONCLUSIONS
These results suggest that D6S1581 is highly associated with NPC, and there may be one or more NPC associated genes near D6S1581, including FBXO30.
Xiong
Wei
W
Cancer Research Institute, Xiangya Medical School, Changsha, Hunan, PR China.
Zeng
Zhao-yang
ZY
Shen
Shou-rong
SR
Li
Xiao-ling
XL
Li
Wei-fang
WF
Wang
Rong
R
Xiong
Fang
F
Peng
Cong
C
Zhang
Qiu-hong
QH
Zhou
Ming
M
Yang
Yi-xin
YX
Zhou
Hou-de
HD
Huang
He
H
Li
Gui-yuan
GY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002681:China; D044783:F-Box Proteins / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D010375:Pedigree
D044783:F-Box Proteins