Synthesis, characterization, and blood compatibility of polyamidoamines copolymers.
This work reports the development of new non-thrombogenic polymers based on the linear polymers of polyamidoamines (PAAs), having heparin binding ability, obtained by polyaddition of secondary amines to N,N'-methylene bis-acrylamide. PAAs could not be used directly in the making of blood-contacting materials due to their poor mechanical strength. In order to overcome this lacuna, copolymers of amidoamine with methylmethacrylate (MMA) were prepared. Characterization studies indicated that the PAAs have been suitably incorporated into the MMA matrix. The relative hydrophilic nature of the synthesized copolymers was established from the measurement of water contact angle. The heparinized copolymers showed significant improvement in non-thrombogenic characteristics.
Dey
Ratan K
RK
Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi 110 016, India.
Ray
Alok R
AR
D000178:Acrylamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001769:Blood / Q000187:drug effects*; D001777:Blood Coagulation / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003514:Cyclohexylamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004355:Drug Stability; D006493:Heparin / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008422:Materials Testing; D020366:Methylmethacrylate / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012995:Solubility; D013499:Surface Properties; D014783:Viscosity
D000178:Acrylamides; C481128:CHA-MBA-MMA; D020099:Coated Materials, Biocompatible; D003514:Cyclohexylamines; C481127:Pip-MBA-MMA; D020366:Methylmethacrylate; D006493:Heparin