title: [Clinical observation on the efficacy of ivermectin in the treatment of intestinal nematode infections].
abstract: OBJECTIVE
  To observe the efficacy and side effects of ivermectin in the treatment of intestinal nematode infections.
  
  
  METHODS
  A single dose of ivermectin 0.1, 0.2, 0.2 and 0.2 mg/kg was orally administered to cases with infection of Ascaris, hookworm, Trichuris and Enterobius respectively. A single dose of albendazole 400 mg was used as control.
  
  
  RESULTS
  The egg negative conversion rates of ivermectin and albendazole were both 100% (34/34) for Ascaris infection, 17.6% (6/34) and 76.5% (26/34) respectively for hookworm infection, 67.6% (23/34) and 47.1% (16/34) respectively for Trichuris infection, 58.8% (20/34) and 100% (34/34) respectively for Enterobius infection. The worm discharge reached a peak in 1-2 days after treatment. The side effect of ivermectin was mild and transient showing no adverse effect on blood picture, liver function, renal function or ECG.
  
  
  CONCLUSIONS
  Ivermectin shows similar effect on Ascaris with albendazole, better effect on Trichuris and poorer effect on hookworm and Enterobius than albendazole.
authors.affiliation: Institute of Parasitic Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013.
authors.forename: Li-yong
authors.initials: LY
authors.lastname: Wen
authors.forename: Si-wen
authors.initials: SW
authors.lastname: Li
authors.forename: Ling-juan
authors.initials: LJ
authors.lastname: Wu
authors.forename: Ji-shun
authors.initials: JS
authors.lastname: Yang
authors.forename: Xiao-lan
authors.initials: XL
authors.lastname: Yan
authors.forename: Ming-jin
authors.initials: MJ
authors.lastname: Yang
authors.forename: Lei-jun
authors.initials: LJ
authors.lastname: Lou
authors.forename: Fu-chu
authors.initials: FC
authors.lastname: Zhan
authors.forename: Xu-yang
authors.initials: XY
authors.lastname: Wang
authors.forename: Tu-rong
authors.initials: TR
authors.lastname: Li
authors.forename: Jian-qiang
authors.initials: JQ
authors.lastname: Shao
authors.forename: Jin-chun
authors.initials: JC
authors.lastname: Zheng
authors.forename: Mei-hua
authors.initials: MH
authors.lastname: Fu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015766:Albendazole / Q000627:therapeutic use; D000969:Antinematodal Agents / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy*; D007559:Ivermectin / Q000627:therapeutic use*; D008875:Middle Aged; D009349:Nematode Infections / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000969:Antinematodal Agents; D007559:Ivermectin; D015766:Albendazole