title: Effect of pericardial fluid pro-inflammatory cytokines on hemodynamic parameters.
abstract: We investigated the effects of pro-inflammatory cytokines of pericardial fluid on hemodynamic parameters in patients undergoing coronary artery surgery. Seventy-eight patients were included in the study and they were allocated to three groups: group 1, stable angina pectoris (SAP, n = 15); group 2, unstable angina pectoris (USAP, n = 34); group 3, post-myocardial infarction (PMI, n = 29). Pericardial fluid and arterial blood samples were obtained from all patients and interleukin (IL)-1beta, IL-2 receptor, IL-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha) levels were measured. Pericardial IL-1beta concentration (pg/mL) was significantly higher in the USAP group (26.6 +/- 10.9) compared to the SAP (5.0 +/- 0.1) and PMI (5.8 +/- 1.0) groups. IL-2R, IL-6, IL-8 and TNF-alpha concentrations of pericardial fluid were significantly higher than serum in all groups; difference was more prominent in the PMI group compared to the SAP and the USAP groups. Serum IL-1beta concentrations (pg/mL) were significantly higher in the USAP group (21.8 +/- 3.4) compared to the SAP group (5.0 +/- 0.1) and the PMI group (5.4 +/- 1.6). Cardiac index (CI) before opening the pericardial sac was found to be lower in the USAP group (1.6 +/- 0.3 L/min/m2) compared to the SAP (2.2 +/- 0.5 L/min/m2) and the PMI (2.1 +/- 0.5 L/min/m2) groups (p = 0.028 and p = 0.011, respectively). In the USAP group, there was a relationship between reduction of CI and increase of IL-1beta levels in serum and pericardial fluid.
authors.affiliation: Department of Cardiovascular Surgery, Medical Faculty, Trakya University, TR 22030 Edirne, Turkey. turanege@ttnet.net.tr
authors.forename: Turan
authors.initials: T
authors.lastname: Ege
authors.forename: Suat
authors.initials: S
authors.lastname: Canbaz
authors.forename: Volkan
authors.initials: V
authors.lastname: Yuksel
authors.forename: Enver
authors.initials: E
authors.lastname: Duran
mesh_terms: D000704:Analysis of Variance; D002302:Cardiac Output / Q000502:physiology; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006321:Heart / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000378:metabolism*
chemical_list: D016207:Cytokines; D007375:Interleukin-1