title: RNA as a transcriptional activator.
abstract: Two recent reports demonstrate that in vivo selection can isolate novel RNAs that activate transcription when tethered to a gene promoter. This highlights the structural plasticity that allows RNA to fulfill many functions normally carried out by proteins.
authors.affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: Joel M
authors.initials: JM
authors.lastname: Gottesfeld
authors.forename: Carlos F
authors.initials: CF
authors.lastname: Barbas
mesh_terms: D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D009154:Mutation / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics; D012313:RNA / Q000737:chemistry / Q000494:pharmacology*; D014157:Transcription Factors; D014158:Transcription, Genetic / Q000187:drug effects*
chemical_list: D014157:Transcription Factors; D012313:RNA