title: Aggressive angiomyxoma: an ultrastructural study of four cases.
abstract: The histogenesis of the aggressive angiomyxoma of the vulvo-vaginal region was studied. Four cases of aggressive angiomyxoma were examined by using light microscopy, electron microscopy, and immunohistochemistry. Myofibroblastic from smooth muscle cell differentiation was distinguished by paying close attention to the structures of the neoplastic cell membrane. Aggressive angiomyxomas exhibit subtle features of smooth muscle differentiation, suggesting that the neoplastic cells differentiate from a multipotent perivascular cell.
authors.affiliation: Departamento de Anatomia Patolgica, Hospital 12 de Octubre, Madrid, Spain. mmartinez.hdoc@salud.madrid.org
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Martinez
authors.forename: Claudio
authors.initials: C
authors.lastname: Ballestín
authors.forename: Esperanza
authors.initials: E
authors.lastname: Carabias
authors.forename: Carmen
authors.initials: C
authors.lastname: González Lois
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic; D005260:Female; D005347:Fibroblasts / Q000737:chemistry / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008875:Middle Aged; D032389:Myocytes, Smooth Muscle / Q000737:chemistry / Q000648:ultrastructure; D009232:Myxoma / Q000737:chemistry / Q000473:pathology*; D009363:Neoplasm Proteins / Q000032:analysis; D014625:Vaginal Neoplasms / Q000737:chemistry / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins