Facile synthesis of an azido-labeled thalidomide analogue.
[reaction: see text] A five-step synthesis of an azido-thalidomide analogue is presented. The sequence requires cheap and readily available starting materials and reagents, and only two steps require purification. Additionally, the azido-labeled analogue possesses activity comparable to that of thalidomide in inhibiting the proliferation of human microvascular endothelial cells, thus providing impetus for its use as a potential photoaffinity label of thalidomide.
Capitosti
Scott M
SM
Department of Chemistry, University of Virginia, P.O. Box 400319, Charlottesville, Virginia 22904, USA.
Hansen
Todd P
TP
Brown
Milton L
ML