title: Differentiation therapy.
abstract: Differentiation therapy is an area of oncology that is in its infancy. Theoretically, the concept of differentiation therapy involves turning a cancer cell "off" biologically and reverting to a more "benign" phenotype. Many agents have been studied over the past few years, with many already either in use clinically or showing future promise.
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, CRB Room 1M89, Baltimore, MD 21231, USA. spiraal@jhmi.edu
authors.forename: Alexander I
authors.initials: AI
authors.lastname: Spira
authors.forename: Michael A
authors.initials: MA
authors.lastname: Carducci
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001151:Arsenic / Q000494:pharmacology / Q000627:therapeutic use; D002087:Butyrates / Q000494:pharmacology / Q000627:therapeutic use; D002454:Cell Differentiation / Q000187:drug effects*; D002986:Clinical Trials as Topic; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010654:Phenylbutyrates / Q000494:pharmacology / Q000627:therapeutic use; D012176:Retinoids / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D002087:Butyrates; D056572:Histone Deacetylase Inhibitors; D010654:Phenylbutyrates; D012176:Retinoids; D001151:Arsenic