Gas chromatographic separation of saturated aliphatic hydrocarbon enantiomers on permethylated beta-cyclodextrin.
Enantiomers of chiral aliphatic hydrocarbons are generally difficult to separate because they lack functional groups to be derivatized in order to generate diastereomers. The systematic and quantitative separation of a series of branched hydrocarbon enantiomers using a chiral cyclodextrin stationary phase and a cryostat-controlled gas chromatograph is described. The use of a cryogenic system allows the improvement of separations for various chiral aliphatic hydrocarbons. The molecular cyclodextrin-based mechanism of the achieved enantiomeric separations is discussed briefly. Possible applications of this analytical technique are summarized, with special emphasis on the planned enantiomeric separation experiment on a cometary nucleus.
Meierhenrich
Uwe J
UJ
University of Bremen, Department of Physical Chemistry, Bremen, Germany.
Nguyen
Mai-Julie
MJ
Barbier
Bernard
B
Brack
André
A
Thiemann
Wolfram H P
WH
D002849:Chromatography, Gas / Q000379:methods*; D003505:Cyclodextrins / Q000737:chemistry*; D006838:Hydrocarbons / Q000737:chemistry*; D008745:Methylation; D012833:Siloxanes / Q000737:chemistry; D013696:Temperature; D013997:Time Factors; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D006838:Hydrocarbons; D012833:Siloxanes; D047392:beta-Cyclodextrins; C031215:betadex