Importance of cytochrome P450-mediated metabolism in the mechanism of action of vitamin D analogs.
The elucidation of the metabolic pathway for vitamin D, including the delineation of the specific cytochrome P450s (CYPs) involved in activation and catabolism, has emphasized the overall importance of metabolic considerations in vitamin D analog design. This short review attempts to summarize recent findings with isolated CYPs and animal models in which CYPs are genetically manipulated to draw attention to structural features of vitamin D analogs that make them more or less resistant to metabolic enzymes. We conclude by placing metabolic considerations in the context of the other important aspects of vitamin D analogs.
Masuda
Sonoko
S
Department of Biochemistry, Queen's University, Kingston, ON K7L 3N6, Canada.
Gao
Mian
M
Zhang
Anqi
A
Kaufmann
Martin
M
Jones
Glenville
G
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology*; D004351:Drug Resistance; D005544:Forecasting; D006801:Humans; D008658:Inactivation, Metabolic; D009369:Neoplasms / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D014807:Vitamin D / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology
D014807:Vitamin D; D003577:Cytochrome P-450 Enzyme System