[Effects of statins on coronary artery disease. Review of the recent publications].
This review describes the role of statins in the primary and secondary prevention of coronary artery disease and the clinical benefit of therapy with statins in different forms of coronary artery disease (stable, unstable and myocardial infarction). Presented clinical trials have provided data that statins not only reduce plasma total cholesterol and LDL-cholesterol levels but also reduce major coronary event rate and all-cause mortality. Treatment with statins is usually well tolerated. The mean total cost of care to reach LDL-cholesterol target is significantly lower with atorvastatin than with the other statins.
Bednarz
Bronisław
B
Szpital Grochowski, Klinika Kardiologii CMKP 04-073 Warszawa, ul. Grenadierów 51/59. bednarz@kkcmkp.pl
D000924:Anticholesteremic Agents / Q000191:economics / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000069059:Atorvastatin; D008078:Cholesterol, LDL / Q000187:drug effects; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000517:prevention & control; D006538:Heptanoic Acids / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000191:economics / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011758:Pyrroles / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic
D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin