Is beta-amyloid fibrillogenesis a strict process of deposition inherently interactive in molecular terms?
Amyloid fibrillogenesis as a process of interactive molecular processes of deposition in Alzheimer's disease might function as a phenomenon that transforms intracellular amyloid segregation to a state of equilibration with extracellular deposition. beta-Amyloidosis might dynamically implicate loss of viability of vascular tunica media myofibers as a strict reflection of loss of viability of neurons in such an overall system of equilibration between intracellular and extracellular amyloid fibrillogenesis. In terms beyond simple concepts of strict biophysical equilibration, deposition of beta-amyloid in Alzheimer's disease might constitute a phenomenon of congophilic angiopathy as a strict pathobiologic index of activity of the Alzheimer process; such a correlate would perhaps involve a quantitative index that would qualitatively characterize the Alzheimer process as an interactive series of reactions between the intracellular and extracellular microenvironment.
Agius
L M
LM
St Luke's Hospital, University of Malta, Msida, Malta. lawrence.agius@um.edu.mt
D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000686:Amyloidosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000378:metabolism; D001927:Brain Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D002470:Cell Survival; D006801:Humans; D008954:Models, Biological; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology; D009410:Nerve Degeneration; D016874:Neurofibrillary Tangles / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D011485:Protein Binding
D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4; D001057:Apolipoproteins E