title: [A case of coronary artery spasm during epidural anesthesia with continuous infusion of propofol].
abstract: A 50-year-old male patient was scheduled for left partial pulmonary resection and biopsy. The patient had neither complication nor history of ischemic heart disease. After arriving in the operation room, an epidural catheter was inserted into the epidural space at the T 4-5 intervertebral space. Anesthesia was induced with intravenous propofol 100 mg, fentanyl 100 microgram and vecuronium 6 mg and then a double lumen endotracheal tube was inserted. Anesthesia was maintained with O2 and air (FIO2 0.3-1.0), continuous infusion of propofol, intermittent intravenous administration of fentanyl and epidural injection of 1% lidocaine. Forty-five minutes after the start of operation, ECG showed an elevation of ST segment and soon it passed into ventricular tachycardia and ventricular fibrillation. The patient was treated with cardiopulmonary resuscitation. Fifteen minutes later, ECG returned to sinus rhythm but the elevation of ST segment remained. We considered that these cardiac events were due to coronary spasm, and started continuous infusion of nitroglycerin and nicorandil. One hour later, ST segment returned to normal. The possible inducing factors in this case were altered balance between sympathetic and parasympathetic nervous activity caused by infusion of propofol and epidural block, and alpha-stimulation caused by ephedrine.
authors.affiliation: Department of Anesthesiology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya 343-8555.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Inoue
authors.forename: Katsumi
authors.initials: K
authors.lastname: Ogawa
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Takano
authors.forename: Isao
authors.initials: I
authors.lastname: Sato
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Okuda
mesh_terms: D000767:Anesthesia, Epidural / Q000009:adverse effects*; D001706:Biopsy; D003329:Coronary Vasospasm / Q000209:etiology*; D006801:Humans; D007262:Infusions, Intravenous; D007431:Intraoperative Complications / Q000209:etiology*; D008168:Lung / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects
chemical_list: D015742:Propofol