Metabolism of PGP peptide after administration via different routes.
Main pathways of degradation of PGP peptide possessing antiulcer and antithrombotic activities were studied after its intraperitoneal, intragastric, and intraintestinal administration. In experiments on rabbits we showed by HPLC that unmodified PGP is released into the blood after administration by all three routes and is detected in the plasma over 3-5 h. PG dipeptide is a more stable PGP metabolite presumably determining (together with tripeptide) its pharmacological properties.
Zolotarev
Yu A
YA
Department of Chemistry of Physiologically Active Substances, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow.
Zhuikova
S E
SE
Ashmarin
I P
IP
Myasoedov
N F
NF
Vas'kovskii
B V
BV
Samonina
G E
GE
D000818:Animals; D004333:Drug Administration Routes; D005260:Female; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism*; D011817:Rabbits; D014316:Tritium / Q000378:metabolism
D010455:Peptides; D014316:Tritium