title: Polyhydroxylated steroids and other constituents of the soft coral Nephthea chabroli.
abstract: Polyhydroxylated steroids and other metabolites were isolated from the soft coral Nephthea chabroli collected in South China Sea. The structures of two new compounds were determined to be 24-methylcholesta-9(11), 24(28)-diene-3beta,12alpha,19-triol and 4alpha-methyl-3beta,14beta-dihydroxy-5alpha-ergost-24(28)-en-23-one on the basis of spectroscopic analysis. Cytotoxic activities of the polyhydroxylated sterols were evaluated on prostate carcinoma LNCaP cell line.
authors.affiliation: Hutchison Medipharma Ltd., Shanghai, China. chect@cuhk.edu.hk
authors.forename: Weihan
authors.initials: W
authors.lastname: Zhang
authors.forename: Wing Keung
authors.initials: WK
authors.lastname: Liu
authors.forename: Chun-Tao
authors.initials: CT
authors.lastname: Che
mesh_terms: D000818:Animals; D037421:Anthozoa; D045744:Cell Line, Tumor; D006801:Humans; D006900:Hydroxylation; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D013256:Steroids