Histological examination of the Loeventhal gland after experimental administration of Metizol.
The Loeventhal gland of the white Wistar rats was examined. The animals were given Metizol for 21 days and 42 days at the dose of 1 mg/kg b.m./24 h. The Loeventhal gland's samples were taken for histological and histochemical examination. Then they there stained with hematoxylin and eosin, Masson's, PAS's, and Feulgen's method. The mean area of section of cell nuclei was measured. Results of examination were counted statistically. The following changes were noticed: after 21 days of administration of Metizol in the Loeventhal gland the mean area of the section of cells nuclei was decreased; after 42 days of administration of Metizol the mean area of the section of cell nuclei was decreased as well, but to a lesser degree than in group 1. New follicles appeared which can be the expression of cell mitotic activity.
Lis-Sochocka
Marta
M
Department and Institute of Histology and Embryology, Medical University of Lublin.
Zarebska
Alicja
A
Cichacz-Kwiatkowska
Beata
B
Łańcut
MirosŁaw
M
Koziej
Jacek
J
Czerny
Krystyna
K
D000818:Animals; D013956:Antithyroid Agents / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects / Q000473:pathology; D004334:Drug Administration Schedule; D008297:Male; D008713:Methimazole / Q000633:toxicity*; D010306:Parotid Gland / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D013956:Antithyroid Agents; D008713:Methimazole