title: Dissolution testing of acetylsalicylic acid by a channel flow method-correlation to USP basket and intrinsic dissolution methods.
abstract: A new modification of the channel flow dissolution method is introduced together with the theoretical basis to extract the solubility and mass transfer parameters from the dissolution experiments. Correlation of drug dissolution profiles in the channel flow apparatus was evaluated with respect to USP basket and intrinsic dissolution methods at pH 1.2 or 6.8. Acetylsalicylic acid (ASA) was studied as a pure drug substance and as three simple tablet compositions with microcrystalline cellulose (MCC) and/or lactose as excipients. The channel flow measurements of 100% ASA tablets correlated well with the results of intrinsic dissolution tests. In the channel flow method as well as in the USP basket method the release of ASA was fastest from the tablet compositions containing lactose, while the slowest dissolution rate was observed with the composition containing MCC as the only excipient. As presumed, the dissolution rate of the weak acid was decreased as the pH of the medium was lowered, which was clearly confirmed also by the three dissolution methods. MCC forms matrix tablets and in the USP basket method the dissolution profiles followed square root of time kinetics indicating that diffusion was the rate-controlling step of ASA dissolution. Also the channel flow results indicated that the dissolution of ASA was controlled by mass transfer. The swelling behaviour of the tablets is different in the channel flow method as compared to the basket method: only one tablet surface is exposed to the dissolution medium in the channel flow system. The contact between the tablet surface and the dissolution medium is more similar between the channel flow and intrinsic dissolution methods.
authors.affiliation: Department of Pharmacy, Pharmaceutical Technology Division and Viikki Drug Discovery Technology Center, University of Helsinki, Helsinki, Finland. leena.peltonen@helsinki.fi
authors.forename: Leena
authors.initials: L
authors.lastname: Peltonen
authors.forename: Peter
authors.initials: P
authors.lastname: Liljeroth
authors.forename: Tiina
authors.initials: T
authors.lastname: Heikkilä
authors.forename: Kyösti
authors.initials: K
authors.lastname: Kontturi
authors.forename: Jouni
authors.initials: J
authors.lastname: Hirvonen
mesh_terms: D000465:Algorithms; D001241:Aspirin / Q000737:chemistry*; D002021:Buffers; D002482:Cellulose; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D005079:Excipients; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007785:Lactose; D010602:Pharmacopoeias as Topic; D012995:Solubility; D013607:Tablets; D014481:United States
chemical_list: D002021:Buffers; D005079:Excipients; D013607:Tablets; D002482:Cellulose; D007785:Lactose; C109691:microcrystalline cellulose; D001241:Aspirin