Cytotoxic activity of steroidal glycosides from solanum plants.
Since some Solanum-genera plants have traditionally been used as anti-cancer and anti-herpes agents from olden times, we examined the cytotoxic activity of typical steroidal glycosides with the framework of spirostane, furostane, spirosolane, and pregnane obtained from Solanum plants. Among these steroidal glycosides, the spirostanol glycosides having a beta-lycotetraosyl moiety were the most effective against PC-12 and HCT-116 cell lines. The potency of activity was observed to be decreased in the order of spirostane, furostane, spirosolane, and pregnane type steroid glycosides. It was also suggested that the activity depend on the kind of oligosaccharide moiety and aglycone moiety.
Ikeda
Tsuyoshi
T
Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan. tikeda@gpo.kumamoto-u.ac.jp
Tsumagari
Hidetsugu
H
Honbu
Takehiko
T
Nohara
Toshihiro
T
D000818:Animals; D003603:Cytotoxins / Q000737:chemistry / Q000633:toxicity*; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D045325:HCT116 Cells; D006801:Humans; D016716:PC12 Cells; D010840:Phytosterols / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D032322:Solanum / Q000633:toxicity*
D003603:Cytotoxins; D006027:Glycosides; D010840:Phytosterols