title: Efficacy of selected oral chemotherapeutants against Ichthyophthirius multifiliis (Ciliophora: Ophyroglenidae) infecting rainbow trout Oncorhynchus mykiss.
abstract: The chemotherapeutic efficacy of 6 in-feed compounds against Ichthyophthirius multifiliis Fouquet, 1876 was assessed using experimental infections of rainbow trout Oncorhynchus mykiss (Walbaum) fingerlings. Trial doses of 104 ppm amprolium hydrochloride or 65 ppm clopidol fed to fish for 10 d prior to infection significantly reduced the number of trophonts establishing in trout fingerlings by 62.0 and 35.2% respectively. In-feed treatments of infected trout with either 63 or 75 ppm amprolium hydrochloride, 92 ppm clopidol, or 38, 43 or 47 ppm salinomycin sodium for 10 d also significantly reduced the number of surviving trophonts by 77.6 and 32.2% for amprolium, 20.1% for clopidol and 80.2, 71.9 and 93.3% respectively for salinomycin sodium.
authors.affiliation: Institute of Aquaculture, University of Stirling, Stirling FK9 4LA, United Kingdom. aps1@stir.ac.uk
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Shinn
authors.forename: Rodney
authors.initials: R
authors.lastname: Wootten
authors.forename: Isabelle
authors.initials: I
authors.lastname: Côté
authors.forename: Christina
authors.initials: C
authors.lastname: Sommerville
mesh_terms: D000284:Administration, Oral; D000670:Amprolium / Q000627:therapeutic use; D000821:Animal Feed; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016798:Ciliophora / Q000187:drug effects* / Q000254:growth & development; D016770:Ciliophora Infections / Q000188:drug therapy / Q000662:veterinary*; D003007:Clopidol / Q000008:administration & dosage / Q000627:therapeutic use; D003667:Decoquinate / Q000008:administration & dosage / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005393:Fish Diseases / Q000188:drug therapy* / Q000469:parasitology; D008985:Monensin / Q000008:administration & dosage / Q000627:therapeutic use; D009528:Nicarbazin / Q000008:administration & dosage / Q000627:therapeutic use; D017686:Oncorhynchus mykiss / Q000469:parasitology*; D011714:Pyrans / Q000008:administration & dosage / Q000627:therapeutic use; D011897:Random Allocation; D016896:Treatment Outcome; D000095662:Polyether Polyketides
chemical_list: D000670:Amprolium; D000981:Antiprotozoal Agents; D003007:Clopidol; D003667:Decoquinate; D008985:Monensin; D009528:Nicarbazin; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides