Answers and questions from the KvAP structures.
The recent landmark structures of KvAP, a voltage-gated potassium (Kv) channel, provide the first high-resolution experimental structural models of this class of proteins. Previous extensive studies of Kv channels provide a means to evaluate and interpret the KvAP structures. In this minireview, we survey different experimental approaches to Kv channels and map these findings to KvAP, showing that the relationship between the KvAP structures and other Kv channels is uncertain.
Cohen
Bruce E
BE
Howard Hughes Medical Institute and Departments of Physiology and Biochemistry, University of California, San Francisco, San Francisco, California 94143, USA.
Grabe
Michael
M
Jan
Lily Yeh
LY
D000818:Animals; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D009154:Mutation; D024642:Potassium Channels, Voltage-Gated / Q000737:chemistry* / Q000502:physiology*; D013329:Structure-Activity Relationship
D024642:Potassium Channels, Voltage-Gated