Preparation and characterization of glassy celecoxib.
Celecoxib, a poorly water-soluble drug, was converted into a glassy state by melt quenching. The properties of glassy celecoxib were studied using infrared (IR) spectroscopy, differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), intrinsic dissolution rate (IDR), and thin-layer-chromatography (TLC). Glass transition occurred at 51.8 degrees C. Infrared spectrum of glass has revealed significant changes due to H-bonding. Celecoxib glass shows around 15 times faster dissolution as compared with the crystalline state. Heckel plot analysis has shown better compressibility in glassy state. Unpulverized glass remained stable for 3 months, whereas after pulverization about 70% crystallinity was gained in 100 hours. Further attempts may be carried out to stabilize the glass.
Paradkar
A R
AR
Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune, Maharashtra State, India. arparadkar@rediffmail.com
Chauhan
B
B
Yamamura
S
S
Pawar
A P
AP
D002152:Calorimetry, Differential Scanning / Q000379:methods; D000068579:Celecoxib; D002855:Chromatography, Thin Layer / Q000379:methods; D003460:Crystallization / Q000379:methods*; D004355:Drug Stability; D066298:In Vitro Techniques; D033362:Powder Diffraction / Q000379:methods; D011720:Pyrazoles; D012996:Solutions; D013055:Spectrophotometry, Infrared / Q000379:methods; D013449:Sulfonamides / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors; D014961:X-Ray Diffraction / Q000379:methods
D011720:Pyrazoles; D012996:Solutions; D013449:Sulfonamides; D000068579:Celecoxib