Evaluation of antipyretic potential of Vernonia cinerea extract in rats.
The methanol extract of the whole plant of Vernonia cinerea (MEVC) was evaluated for its antipyretic potential on normal body temperature and yeast-induced pyrexia in rats. MEVC significantly reduced the normal body temperature at doses of 250 and 500 mg/kg body weight p.o. MEVC also lowered the elevated body temperature in the case of yeast-induced pyrexia in a dose dependent manner. The antipyretic effect of the extract at a dose of 500 mg/kg was identical to that of the standard drug paracetamol.
Gupta
Malaya
M
Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700032, India.
Mazumder
U K
UK
Manikandan
L
L
Bhattacharya
S
S
Haldar
P K
PK
Roy
S
S
D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005334:Fever / Q000517:prevention & control*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018514:Plant Structures; D051381:Rats; D035741:Vernonia; D015003:Yeasts
D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts