Regulation of matrix metalloproteinase (matrixin) genes in blood vessels: a multi-step recruitment model for pathological remodelling.
Matrix metalloproteinases (MMPs; matrixins) are a family of structurally related enzymes that collectively promote turnover of all components of the extracellular matrix. Matrix turnover is required for vascular repair, but, if excessive, leads to pathologies that include aneurysm formation and atherosclerotic plaque instability. We review the positive and negative regulation of metalloproteinase gene induction. We propose that multiple steps of gene induction recruit a wider spectrum of MMPs, which may ultimately lead to a transition from matrix turnover to matrix destruction. Studying the detailed mechanisms involved may suggest possibilities for intervening selectively against pathological MMP induction.
Chase
Alex J
AJ
Bristol Heart Institute, University of Bristol, Bristol, UK.
Newby
Andrew C
AC
D000818:Animals; D001808:Blood Vessels / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000235:genetics*; D015533:Transcriptional Activation; D014652:Vascular Diseases / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology*
D020782:Matrix Metalloproteinases