Comparison of sotalol versus amiodarone in maintaining stability of sinus rhythm in patients with atrial fibrillation (Sotalol-Amiodarone Fibrillation Efficacy Trial [Safe-T]).
The Sotalol-Amiodarone Fibrillation Efficacy Trial (SAFE-T) is a randomized, double-blind, multicenter, placebo-controlled trial in which the effects of sotalol and amiodarone in maintaining stability of sinus rhythm are being examined in patients with persistent atrial fibrillation at 20 Veterans Affairs medical centers. The time to the occurrence of atrial fibrillation or flutter in patients with atrial fibrillation converted to sinus rhythm is the primary outcome measure, with a number of parameters as secondary end points. SAFE-T had randomized 665 patients when enrollment terminated on October 31, 2001. Follow-up of patients continued until October 31, 2002, for a maximum period of 54 months and a minimum period of 12 months for all patients.
Singh
Steven N
SN
Division of Cardiology, Veterans Affairs Medical Center, Washington, DC 20422, USA. steve.singh@med.va.gov
Singh
Bramah N
BN
Reda
Domenic J
DJ
Fye
Carol L
CL
Ezekowitz
Michael D
MD
Fletcher
Ross D
RD
Sharma
Satish C
SC
Atwood
J Edwin
JE
Jacobson
Alan K
AK
Lewis
H Daniel
HD
Antman
Eliott M
EM
Falk
Rodney H
RH
Lopez
Becky
B
Tang
X Charlene
XC
D000368:Aged; D000638:Amiodarone / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D013015:Sotalol / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D013015:Sotalol; D000638:Amiodarone