title: Antinociceptive and anti-inflammatory effects of Croton malambo bark aqueous extract.
abstract: Croton malambo (K.) bark aqueous extract, popularly known in Venezuela as "palomatias" or "torco" was tested for acute toxicity and for its anti-inflammatory and antinociceptive effects using tail flick and writhing syndrome tests models, respectively. Croton malambo aqueous extract (6.15 mg/kg i.p.) administered intraperitoneally had a significant antinociceptive and anti-inflammatory effects compared to acetylsalicylic acid (200mg/kg p.o.) and sodium diclofenac (5.64 mg/kg p.o.). Studies to determine correlation between chemical composition and pharmacological activity are underway.
authors.affiliation: Facultad de Farmacia, Universidad Central de Venezuela, Apartado 40109, Caracas, Venezuela. asuarez@strix.ciens.ucv.ve
authors.forename: Alírica I
authors.initials: AI
authors.lastname: Suárez
authors.forename: Reinaldo S
authors.initials: RS
authors.lastname: Compagnone
authors.forename: Maria M
authors.initials: MM
authors.lastname: Salazar-Bookaman
authors.forename: Stephen
authors.initials: S
authors.lastname: Tillett
authors.forename: Franco
authors.initials: F
authors.lastname: Delle Monache
authors.forename: Camilo
authors.initials: C
authors.lastname: Di Giulio
authors.forename: Gustavo
authors.initials: G
authors.lastname: Bruges
mesh_terms: D000418:Albumins / Q000009:adverse effects; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D016227:Benzoquinones / Q000009:adverse effects / Q000037:antagonists & inhibitors; D029802:Croton; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D009020:Morphine / Q000494:pharmacology / Q000627:therapeutic use; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000188:drug therapy*; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D023382:Toxicity Tests, Acute; D014687:Venezuela
chemical_list: D000418:Albumins; D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016227:Benzoquinones; D010936:Plant Extracts; C029322:phenylbenzoquinone; D009020:Morphine