Cerebellar activation in opsoclonus: an fMRI study.
It is controversial whether opsoclonus is a cerebellar or brainstem disorder. Two patients whose opsoclonus largely disappeared on eye closure underwent fMRI. A comparison of these two states revealed neither vermal nor brainstem activation but rather a bilateral activation in the deep cerebellar nuclei in excess of what the authors found in healthy subjects. The results support a crucial role of the fastigial nucleus in opsoclonus.
Helmchen
C
C
Department of Neurology, University of Lübeck, Germany. helmchen_ch@neuro.mu-luebeck.de
Rambold
H
H
Sprenger
A
A
Erdmann
C
C
Binkofski
F
F
D000328:Adult; D000368:Aged; D002529:Cerebellar Nuclei / Q000503:physiopathology; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005133:Eye Movements / Q000502:physiology; D005260:Female; D005403:Fixation, Ocular; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015835:Ocular Motility Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D012016:Reference Values; D014057:Tomography, X-Ray Computed