[Antibodies to herpesvirus type 8 in Kaposi's sarcoma patients and controls in Russia].
The purpose of the present study was to investigate the HH-8 seroprevalence among patients with Kaposi's sarcoma (KS), melanoma and gastric carcinoma (GC) as well as among renal recipients and blood donors. The obtained data revealed a high percentage of seropositive KS patients, which ranged from 83.6% in the classical disease type to 68.8% and to 71.4% in the immunosuppressive and AIDS-associated disease types, respectively. On the whole, the positive humoral response to HHV-8 reliably correlated with the positive findings if the viral genetic information in tumor tissue samplings. An unexpectedly high percentage of seropositive persons was found among the GC patients (41.8%) and among the renal recipients (26%), which is apparently predetermined by the immunosuppressive condition of such patients. Seroprevalence was found only in 4% of blood donors. Thus, the obtained data make it possible to conclude that KS cases, as diagnosed in Russia, are tensely associated with HHV-8 in spite of a low virus spread among the healthy population. Patients with pathology concomitant with a pronounced immunosuppression are characterized by a high prevalence of HHV-8 and belong to the category of persons with a KS risk.
Gurtsevich
V E
VE
Iakovleva
L S
LS
Kadyrova
E L
EL
Chernova
V A
VA
Molochkov
A V
AV
Kosukhina
N V
NV
Agrba
V Z
VZ
Molochkov
V A
VA
D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D000914:Antibodies, Viral / Q000097:blood*; D004279:DNA, Viral / Q000032:analysis; D019084:Fluorescent Antibody Technique, Indirect; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007165:Immunosuppression Therapy; D012426:Russia / Q000453:epidemiology; D012514:Sarcoma, Kaposi / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral; D004279:DNA, Viral