[Studies on structure modification of (+)-praeruptorin A].
OBJECTIVE
In order to look for new active compounds, the structure of (+)-praeruptorin A is modified.


METHODS
(+)-Praeruptorin A was isolated from the root of Peucedanum praeruptorum, basic hydrolysis of (+)-praeruptorin A and acyled reactions of hydrolysis product of (+)-praeruptorin A were carried out.


RESULTS
Eighteen compounds were semi-synthesized from (+)-praeruptorin A.


CONCLUSIONS
Fourteen compounds (5-18) among them are new compounds. Preliminary bioactivity assay indicated that the new compounds show calcium antagonist activity, but they are not as strong as (+)-praeruptorin A.
Wu
Xian-li
XL
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210038, China.
Kong
Ling-yi
LY
Min
Zhi-da
ZD
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D019661:Apiaceae / Q000737:chemistry; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats
D002121:Calcium Channel Blockers; D003374:Coumarins; D004365:Drugs, Chinese Herbal; C441070:praeruptorin A