title: Molecular epidemiology of Haemophilus influenzae type b isolated from children with clinical cases of conjugate vaccine failures.
abstract: We analyzed eight invasive Haemophilus influenzae strains isolated from individual children vaccinated appropriately for their ages. Five of the strains were type b and three were nontypeable strains. Children infected with nontypeable strains had a protective level of anti-H. influenzae type b antibodies, while only one of the children whose cases represented true vaccine failure did.
authors.affiliation: Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ministry of Health, Madrid, Spain. jcampos@iscii.es
authors.forename: José
authors.initials: J
authors.lastname: Campos
authors.forename: Belén
authors.initials: B
authors.lastname: Aracil
authors.forename: Federico
authors.initials: F
authors.lastname: Román
authors.forename: María
authors.initials: M
authors.lastname: Pérez-Vázquez
mesh_terms: D002675:Child, Preschool; D015658:HIV Infections / Q000150:complications; D006192:Haemophilus Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D018073:Haemophilus Vaccines / Q000627:therapeutic use*; D019741:Haemophilus influenzae type b / Q000145:classification / Q000235:genetics*; D006801:Humans; D007223:Infant; D017720:Molecular Epidemiology; D010802:Phylogeny; D012307:Risk Factors; D017211:Treatment Failure; D018074:Vaccines, Conjugate / Q000627:therapeutic use*
chemical_list: D018073:Haemophilus Vaccines; D018074:Vaccines, Conjugate