title: Strains of Streptococcus pyogenes from severe invasive infections bind HEp2 and HaCaT cells more avidly than strains from uncomplicated infections.
abstract: Epidemiologically unrelated Streptococcus pyogenes strains isolated from blood, throat, and skin were assayed for adherence to HEp2 and HaCaT cells. Invasive isolates showed significantly higher avidity for these cell lines than isolates from skin and throat. In general, S. pyogenes showed greater binding to HaCaT cells than to HEp2 cells.
authors.affiliation: Menzies School of Health Research. Cooperative Research Centre for Aboriginal and Tropical Health, Darwin, Australia.
authors.forename: Mandy L
authors.initials: ML
authors.lastname: Edwards
authors.forename: Peter K
authors.initials: PK
authors.lastname: Fagan
authors.forename: Heidi
authors.initials: H
authors.lastname: Smith-Vaughan
authors.forename: Bart J
authors.initials: BJ
authors.lastname: Currie
authors.forename: Kadaba S
authors.initials: KS
authors.lastname: Sriprakash
mesh_terms: D001422:Bacterial Adhesion / Q000502:physiology*; D006801:Humans; D013290:Streptococcal Infections / Q000175:diagnosis*; D013297:Streptococcus pyogenes / Q000145:classification / Q000302:isolation & purification* / Q000502:physiology*; D014407:Tumor Cells, Cultured