Adult carotid chemoafferent responses to hypoxia after 1, 2, and 4 wk of postnatal hyperoxia.
Exposing newborn rats to postnatal hyperoxia (60% O2) for 1-4 wk attenuates the ventilatory and phrenic nerve responses to acute hypoxia in adult rats. The goal of this research was to increase our understanding of the carotid chemoreceptor afferent neural input in this depressed response with different durations of postnatal hyperoxic exposure. Rats were exposed from a few days before birth to 1, 2, or 4 wk of 60% O2 and studied after 3-5 mo in normoxia. The rats were anesthetized with urethane. Whole carotid sinus nerve (CSN) responses to NaCN (40 microg/kg iv), 10 s of asphyxia and acute isocapnic hypoxia (arterial Po2 45 Torr) were determined. Mean CSN responses to stimuli after postnatal hyperoxia were reduced compared with controls. Responses in rats exposed to 1 wk of postnatal hyperoxia were less affected than those exposed to 2 and 4 wk of hyperoxia, which were equivalent to each other. These studies illustrate the importance of normoxia during the first 2 wk of life in development of carotid chemoreceptor afferent function.
Bisgard
G E
GE
Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA. bisgardg@svm.vetmed.wisc.edu
Olson
E B
EB
Wang
Z-Y
ZY
Bavis
R W
RW
Fuller
D D
DD
Mitchell
G S
GS
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001237:Asphyxia / Q000503:physiopathology; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000502:physiology; D002344:Carotid Body / Q000187:drug effects / Q000502:physiology*; D002628:Chemoreceptor Cells / Q000502:physiology*; D004594:Electrophysiology; D005260:Female; D006863:Hydrogen-Ion Concentration; D018496:Hyperoxia / Q000473:pathology / Q000503:physiopathology*; D000860:Hypoxia / Q000473:pathology / Q000503:physiopathology*; D009475:Neurons, Afferent / Q000502:physiology*; D009929:Organ Size / Q000187:drug effects; D011042:Poisons / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012966:Sodium Cyanide / Q000494:pharmacology; D013997:Time Factors
D011042:Poisons; D012966:Sodium Cyanide