title: Therapy of neurological disorders in systemic vasculitis.
abstract: Significant progress has been made in our understanding of the underlying cellular and molecular mechanisms associated with vasculitis. Simultaneous involvement of the nervous system and systemic organs points to shared antigenic targets or immune mechanisms operative at both sites. Although specific immunotherapy is not available, the old and new immunomodulatory therapies have been instrumental in providing effective therapy in most of these chronic autoimmune disorders. The treatment of giant cell arteritis, neurosarcoidosis, Wegener's granulomatosis, systemic lupus erythematosus, polyarteritis, Sjögren's syndrome, and Behcet disease will be reviewed.
authors.affiliation: Department of Neurology, Clinical Research Group for Multiple Sclerosis and Neuroimmunology, Julius-Maximilians-Universität Würzburg, Josef-Schneider-Strasse 11, D-97080 Würzburg, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Gold
authors.forename: Adriano
authors.initials: A
authors.lastname: Fontana
authors.forename: Stephan
authors.initials: S
authors.lastname: Zierz
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D001528:Behcet Syndrome / Q000628:therapy; D013700:Giant Cell Arteritis / Q000628:therapy; D014890:Granulomatosis with Polyangiitis / Q000628:therapy; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008180:Lupus Erythematosus, Systemic / Q000628:therapy; D009422:Nervous System Diseases / Q000628:therapy*; D010488:Polyarteritis Nodosa / Q000628:therapy; D011111:Polymyalgia Rheumatica / Q000628:therapy; D012507:Sarcoidosis / Q000628:therapy; D012859:Sjogren's Syndrome / Q000628:therapy; D014657:Vasculitis / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*
chemical_list: D000276:Adjuvants, Immunologic