[Characteristic immunodeficiency syndrome of rapid fatal type of simian immunodeficiency virus infected monkeys].
OBJECTIVE
To observe the characteristic immunodeficiency syndrome of the rapid fatal type of simian immunodeficiency virus (SIV) infected monkeys.


METHODS
Eighty rhesus monkeys and 4 cynomolgus monkeys were intravenously inoculated with SIVmac or SIVmac251. The virus isolation and viral titer, estimation by indirect immunofluroresence and viral antibody were determined periodically from monkeys' plasma; lymph node biopsies were performed for pathohistological examination.


RESULTS
Twelve out of 84 macaque (14.2%) died of rapid progressive type after inoculation of SIVmac and SIVmac251 in the duration 3 to 4 months. Dying monkeys showed persistent high viremia and low level titre antibody. Eight of 10 pathohistological changes showed severe depletion of lymphoid tissue in spleen and lymph nodes, there were remarkable immunodeficiency with opportunity infection. The other two monkeys appeared moderate lymphoid tissue deletion and hyperplasia without opportunity infections. The survived monkeys' (72/84) lymph nodes biopsies revealed hypoplasia of lymphoid tissue.


CONCLUSIONS
The characteristic immunodeficiency syndrome of rapid fatal type of simian immunodeficiency virus infected monkeys could be made with persistent high viremia, low level antibody, severe lymphoid tissue deletion in lymph nodes and spleen, as well as complicated opportunity infections.
Wu
X
X
Department of Virology and Pathology, Institute of Laboratory Animal Sciences, CAMS, PUMC, Beijing 100021, China.
Lu
Y
Y
He
F
F
Qing
C
C
Song
H
H
Cong
Z
Z
Tong
W
W
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology / Q000821:virology