Ultrastructural changes of retinal ganglion cells in rabbits of New Zealand breed after experimental administration of 2-CDA (Cladribine).
The experiment was carried out on rabbit females of New Zealand breed weighing about 3 kg. The animals from the experimental group received. Cladribine in the dose of 0.1 mg/kg for 7 days. Specimens of retina were collected for ultrastructural examinations. It was revealed that administration of Cladribine in the dose corresponding to the therapeutic dose used in human for the treatment of the hairy cell leukemia causes morphological changes in ultrastructure of retinal ganglion cells which are classified as reversible in cytophysiology. The necessity of periodic, regular ophthalmological examinations during Cladribine treatment was indicated.
Kwietniewska
Małgorzata
M
Department of Histology and Embryology, Lab of Experimental Cytology, Medical University of Lublin, Department of Histology and Embryology, Agricultural University of Lublin.
Cybulska
Regina
R
Kwietniewski
Piotr
P
Sekita-Krzak
Joanna
J
Czerny
Krystyna
K
D000818:Animals; D017338:Cladribine / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D007943:Leukemia, Hairy Cell / Q000188:drug therapy; D011817:Rabbits; D012016:Reference Values; D012165:Retinal Ganglion Cells / Q000187:drug effects* / Q000648:ultrastructure*
D007166:Immunosuppressive Agents; D017338:Cladribine