Selective formation of homo- and heterobivalent peptidomimetics.
Methodology is presented for assembling fluorescently labeled bivalent molecules from monovalent constituents, without side chain protection or coupling agents. To illustrate the procedure, a series of bivalent peptidomimetics directed toward the Trk receptors were prepared and screened via fluorescent activated cell sorting scan assays.
Pattarawarapan
Mookda
M
Department of Chemistry, Texas A & M University, Box 30012, College Station, TX 77842-3012, USA.
Reyes
Samuel
S
Xia
Zebin
Z
Zaccaro
Maria C
MC
Saragovi
H Uri
HU
Burgess
Kevin
K
D000596:Amino Acids / Q000737:chemistry*; D002352:Carrier Proteins / Q000378:metabolism; D002460:Cell Line; D020650:Combinatorial Chemistry Techniques; D019281:Dimerization; D005434:Flow Cytometry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D008565:Membrane Proteins / Q000378:metabolism; D018716:Molecular Mimicry; D009414:Nerve Growth Factors / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D020917:Receptor, trkA; D020812:Receptor, trkC / Q000378:metabolism
D000596:Amino Acids; D002352:Carrier Proteins; D005456:Fluorescent Dyes; D006574:Heterocyclic Compounds, 2-Ring; D008565:Membrane Proteins; D009414:Nerve Growth Factors; D010455:Peptides; D020917:Receptor, trkA; D020812:Receptor, trkC