title: [The correlation between DDVP resistance of Culex pipiens pallens and esterase activity].
abstract: OBJECTIVE
  To detect the resistance index and esterase activity of each generation of DDVP-resistant Culex mosquitoes and analyze the relationship between insecticide resistance and esterase.
  
  
  METHODS
  WHO bioassay and micro-plate measurement were used for the detection.
  
  
  RESULTS
  The resistance index increased to 12.17 after 43 generations' insecticide selection compared to 1.00 as sensitive isolate. The nonspecific esterase(NSE) activity of the mosquitoes became strengthened with the extension of the generations, and the individual frequency of those with OD values no less than 0.9 increased gradually, consistent basically to the bioassay. The AChE average inhibition rate decreased with the extended generation and increased resistance, and the individual frequency of those with inhibition rate less than 30% became strengthened with the extension of generations, showing a positive correlation.
  
  
  CONCLUSIONS
  The activity of NSE and AChE shows a correlation with DDVP resistance.
authors.affiliation: Shandong Institute of Parasitic Diseases, Jining 272033.
authors.forename: Xin-guo
authors.initials: XG
authors.lastname: Wang
authors.forename: Tian-min
authors.initials: TM
authors.lastname: Zhen
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Tan
authors.forename: Huai-wei
authors.initials: HW
authors.lastname: Wang
authors.forename: Mao-qing
authors.initials: MQ
authors.lastname: Gong
authors.forename: Chuan-hong
authors.initials: CH
authors.lastname: Sun
authors.forename: Yu-qiang
authors.initials: YQ
authors.lastname: Zhao
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D043182:Carboxylesterase / Q000378:metabolism; D003465:Culex / Q000187:drug effects / Q000201:enzymology*; D004006:Dichlorvos / Q000494:pharmacology*; D004950:Esterases / Q000378:metabolism*; D007305:Insecticide Resistance; D007306:Insecticides / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D004006:Dichlorvos; D004950:Esterases; D043182:Carboxylesterase; D000110:Acetylcholinesterase