title: Rasmussen syndrome: multifocal spread of inflammation suggested from MRI and PET findings.
abstract: BACKGROUND
  A 6-year-old girl with Rasmussen syndrome (RS) showed multiple small high-signal-intensity areas independently in the right hemisphere by fluid-attenuated inversion recovery (FLAIR) imaging on magnetic resonance imaging (MRI) 1 year after the onset of epilepsy.
  
  
  METHODS
  MRI performed 4 months later demonstrated a further increase in the number of these foci and enlargement in the size of the previous FLAIR lesions.
  
  
  RESULTS
  An [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) study showed a strong, spotty uptake in the right temporooccipital regions, corresponding to the sites of continuous EEG seizure discharges. In contrast, [11C]methionine PET demonstrated multifocal uptake regions, which corresponded anatomically to the FLAIR lesions, suggesting sites of underlying chronic inflammation.
  
  
  CONCLUSIONS
  These neuroimaging findings suggested that the inflammatory process in RS spreads either multifocally at the same time, as seen in this case, or from one discrete area to the adjacent region, as reported previously.
authors.affiliation: Department of Pediatrics, Tokyo Woman's Medical University, Tokyo, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Maeda
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Oguni
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Saitou
authors.forename: Ayako
authors.initials: A
authors.lastname: Mutoh
authors.forename: Kaoru
authors.initials: K
authors.lastname: Imai
authors.forename: Makiko
authors.initials: M
authors.lastname: Osawa
authors.forename: Yukio
authors.initials: Y
authors.lastname: Fukuyama
authors.forename: Tomokatsu
authors.initials: T
authors.lastname: Hori
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Yamane
authors.forename: Osamu
authors.initials: O
authors.lastname: Kubo
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishii
authors.forename: Kiichi
authors.initials: K
authors.lastname: Ishiwata
mesh_terms: D001342:Autonomic Nervous System Diseases / Q000175:diagnosis; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D002648:Child; D018450:Disease Progression; D004292:Dominance, Cerebral / Q000502:physiology*; D004660:Encephalitis / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D017036:Epilepsia Partialis Continua / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D004827:Epilepsy; D020938:Epilepsy, Partial, Motor / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008715:Methionine; D009778:Occipital Lobe / Q000473:pathology / Q000503:physiopathology; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D019788:Fluorodeoxyglucose F18; D008715:Methionine