Utilization of in vivo ultrafiltration in biomedical research and clinical applications.
Ultrafiltration (UF) is a filtrate selection method with a wide range of biomedical and clinical applications, including detoxification of blood in hemodialysis and peritoneal dialysis. New is, however, the use of UF as a convenient in vivo sampling method that, for example, has been used in diabetics. Ultrafiltration avoids complicated and time-consuming recovery calculations that are necessary when using in vivo microdialysis, as recoveries of low molecular weight molecules are near 100%. The subcutaneously or intravenously placed UF probes have been studied for off-line sample analysis and for continuous on-line monitoring, in a wide variety of species, including dogs, rats, pigs and humans. This review discusses the potential of in vivo UF as a continuous tissue sampling technique in clinical research areas, and in several major biomedical applications including glucose and lactate monitoring and drug kinetic studies.
Leegsma-Vogt
Gea
G
Department of Psychiatry, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands. g.vogt@acggn.azg.nl
Janle
Elsa
E
Ash
Stephen R
SR
Venema
Kor
K
Korf
Jakob
J
D000818:Animals; D035843:Biomedical Research; D001786:Blood Glucose / Q000032:analysis; D015510:Clinical Medicine / Q000379:methods*; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D004364:Pharmaceutical Preparations / Q000378:metabolism; D014462:Ultrafiltration
D001786:Blood Glucose; D004364:Pharmaceutical Preparations; D019344:Lactic Acid