[Expression of inducible nitric oxide synthase in human esophageal biopsies from carcinoma and precancerous lesions].
OBJECTIVE
To investigate the possible role of inducible nitric oxide synthase (iNOS) in esophageal carcinogenesis.


METHODS
iNOS expressions in normal epithelial cells(NC), hyperplastic cells(HC), atypical hyperplastic cells(AHC) from grade I to III, carcinoma in situ(CIS), squamous cell carcinoma(SCC), and adenocarcinoma(ADC) were detected with immunohistochemistry.


RESULTS
The positive rates of immunohistochemistry staining was 0 for NC, 2.5% for HC, 4.0%, 7.5% and 2.5% for AHC grade I to III respectively, 1.4% for CIS, 8.5% for SCC and 71.4% for ADC.


CONCLUSIONS
There is a high expression of iNOS in human esophageal adenocarcinomas. Frequent expression of iNOS may be a potential event in ADC carcinogenesis. There is no correlation between iNOS and SCC carcinogenesis.
Jin
Y
Y
Detection Center of Tumor Biology, Cancer Institute, CAMS and PUMC, Beijing 100021, China.
Zhang
W
W
Liu
B
B
Wang
H
H
Han
Z
Z
Wang
L
L
Liu
Y
Y
Jin
Y
Y
Qu
P
P
Li
M
M
Ding
Z
Z
Lin
P
P
D000230:Adenocarcinoma / Q000201:enzymology*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology*; D004938:Esophageal Neoplasms / Q000201:enzymology*; D006801:Humans; D007150:Immunohistochemistry; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II; D011230:Precancerous Conditions / Q000201:enzymology*
C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II