title: Magnesium-orotate supplementation for idiopathic infertile male patients: a randomized, placebo-controlled clinical pilot study.
abstract: A randomized, placebo-controlled clinical pilot study was performed in order to examine the effect of magnesium-orotate in male idiopathic infertility. Ten males were treated daily for 90 consecutive days with 3000 mg magnesium-orotate (Magnerot) tablets (Group M). As a control, ten other males were treated in the same way with placebo (Group P). Conventional microscopic sperm characteristics (sperm concentration, motility ratio, total number of motile sperm cells, normal morphology ratio), plus total and ionized magnesium levels in seminal plasma and blood serum were evaluated both prior to treatment and on day 90, at the conclusion of the study. No significant changes in sperm characteristics, blood ionized or total Mg, or ejaculate total Mg levels were detected. However, ejaculate ionized Mg levels increased in Group M from 0.18 +/- 0.05 to 0.30 +/- 0.05 (mmol/l; mean +/- SD, p < 0.05). Within the observation period of 3 months, one pregnancy occurred in the partner of a male from Group M. In conclusion, magnesium-orotate treatment at a dose of 3000 mg/day leads neither to a significant improvement of sperm variables nor does it increase the pregnancy rates of female partners of treated males as compared to those of controls. Thus, magnesium-orotate treatment was not shown to be effective therapy for idiopathic male infertility.
authors.affiliation: Division of Andrology, University of Szeged, Albert Szent-Györgyi Medical and Pharmaceutical Center, Semmelweis u.1. H-6720 Szeged, Hungary. zavaczkiz@hotmail.com
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Závaczki
authors.forename: János
authors.initials: J
authors.lastname: Szöllõsi
authors.forename: Sándor A
authors.initials: SA
authors.lastname: Kiss
authors.forename: Sándor
authors.initials: S
authors.lastname: Koloszár
authors.forename: Imre
authors.initials: I
authors.lastname: Fejes
authors.forename: László
authors.initials: L
authors.lastname: Kovács
authors.forename: Attila
authors.initials: A
authors.lastname: Pál
mesh_terms: D000328:Adult; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D008274:Magnesium / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D008297:Male; D009963:Orotic Acid / Q000627:therapeutic use*; D010865:Pilot Projects; D010919:Placebos; D011247:Pregnancy; D018873:Pregnancy Rate; D012661:Semen / Q000378:metabolism; D013081:Sperm Motility; D013094:Spermatozoa / Q000473:pathology; D013997:Time Factors
chemical_list: D010919:Placebos; D009963:Orotic Acid; D008274:Magnesium