title: [Study of the renal acidification capacity in children diagnosed of idiopathic hypercalciuria].
abstract: OBJECTIVE
  To study the capacity of renal acidification in a group of children diagnosed of idiopathic hypercalciuria.
  
  
  METHODS
  36 children were studied, to those that were determined the pCO2 (UpCO2) maximum urinary with two different stimuli, acetazolamide and sodium bicarbonate (NaHCO3). At 33 of them, was performed an acidification test with frusemide stimulus. We studied a control group of 13 healthy children so much for the first one as the second tests and other 14 healthy children for the acidification test with frusemide.
  
  
  RESULTS
  In the tests performed with NaHCO3 and acetazolamide stimulus, they were not proven differences in the values of UpCO2 neither in the urinary concentration of HCO3- (UHCO3-) than control children. Nevertheless, the UpCO2 and the concentration of UHCO3- in the patients were significantly lower with acetazolamide with regard to the NaHCO3 stimulus. In the acidification test with frusemide, significantly lower values of titratable acid and ammonium were obtained than control children.
  
  
  CONCLUSIONS
  In children with idiopathic hypercalciuria, the capacity of secretion of H+ is normal, what is evidenced, especially, when studying the maximum UpCO2 after stimulus with NaHCO3. When diuretics are used as stimuli, exists more negative results that can be due to a certain partial resistance to the action of the same ones or to that are less potent to induce the secretion of H+.
authors.affiliation: Unidad de Nefrología Pediátrica, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife.
authors.forename: V
authors.initials: V
authors.lastname: García Nieto
authors.forename: M
authors.initials: M
authors.lastname: Monge
authors.forename: L
authors.initials: L
authors.lastname: Hernández Hernández
authors.forename: A
authors.initials: A
authors.lastname: Callejón
authors.forename: M I
authors.initials: MI
authors.lastname: Yanes
authors.forename: V E
authors.initials: VE
authors.lastname: García Rodríguez
mesh_terms: D000141:Acidosis, Renal Tubular / Q000175:diagnosis / Q000503:physiopathology / Q000652:urine; D000293:Adolescent; D002118:Calcium / Q000652:urine*; D002128:Calcium Metabolism Disorders / Q000503:physiopathology* / Q000652:urine; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007684:Kidney Tubules / Q000503:physiopathology*; D008297:Male
chemical_list: D002118:Calcium