title: [Aging features of L-thyroxine action on glycosylphosphatidylinositol metabolism in rat liver].
abstract: L-thyroxine action on GPI and phosphatidylinositol (PI) metabolism in the liver have been investigated in 3- and 24-month-old Wistar rats. PI and GPI were labeled by [14C]acetate Na in vivo and [14C]glucose in vitro. Aging caused a significant decrease in basal PI and GPI levels and reduced [14C]glucose incorporation into GPI of liver. The addition of exogenous PI stimulated the [14C]GPI formation (about 2-3 fold) in 24-month-old rat liver. Thyroxine injection (200 micrograms/100 g weight) to young rats induced triphasic alteration in GPI content in the liver. We observed the marked violation in the thyroxine-mediated GPI-metabolism in the old rats liver. These results indicate that thyroid hormones regulate GPI metabolism in rat liver.
authors.affiliation: Karazin University, Kharkov, Ukraine.
authors.forename: O A
authors.initials: OA
authors.lastname: Krasil'nikova
authors.forename: N S
authors.initials: NS
authors.lastname: Kavok
authors.forename: I V
authors.initials: IV
authors.lastname: Nikitina
authors.forename: N A
authors.initials: NA
authors.lastname: Babenko
mesh_terms: D000085:Acetates / Q000378:metabolism; D000375:Aging; D000818:Animals; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism; D017261:Glycosylphosphatidylinositols / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000494:pharmacology*
chemical_list: D000085:Acetates; D017261:Glycosylphosphatidylinositols; D010716:Phosphatidylinositols; D005947:Glucose; D013974:Thyroxine