Aporphine alkaloids from Guatteria spp. with leishmanicidal activity.
Fractionation of Guatteria amplifolia yielded the alkaloids xylopine (1), nornuciferine (4), lysicamine (6), and laudanosine (5). Fractionation of Guatteria dumetorum yielded the alkaloids cryptodorine (2) and nornantenine (3). Compounds 1-4 demonstrated significant activity against Leishmania mexicana and L. panamensis. Xylopine (1) was among the most active compounds (LD 50 = 3 microM) and showed a 37-fold higher toxicity towards L. mexicana than macrophages, the regular host cells of Leishmania spp.
Montenegro
Hector
H
Gutiérrez
Marcelino
M
Romero
Luz I
LI
Ortega-Barría
Eduardo
E
Capson
Todd L
TL
Rios
Luis Cubilla
LC
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D031043:Guatteria / Q000737:chemistry*; D006801:Humans; D007891:Leishmania / Q000187:drug effects*; D007894:Leishmania mexicana / Q000187:drug effects*
D000470:Alkaloids