Transgenic mouse models of dopamine deficiency.
The dopamine system is implicated in several neurological and psychiatric disorders. Genetic mutations or variations that affect dopamine system functions either directly cause or contribute to these disorders, even though other genetic and environmental factors may contribute significantly to some of these disorders as well. Transgenic mice increasingly become important tools in revealing functions of genes that are essential components of the dopamine system as well as in modeling human genetic disorders. We have reviewed a comprehensive list of those genes and compared genetic mutations/variations in humans and transgenic mouse models. The significance and limitations of these animal models as well as future directions are discussed.
Chen
Linan
L
Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, IL 60637, USA.
Zhuang
Xiaoxi
X
D000818:Animals; D004195:Disease Models, Animal; D004298:Dopamine / Q000172:deficiency* / Q000235:genetics* / Q000502:physiology; D006801:Humans; D001523:Mental Disorders / Q000235:genetics / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic; D009422:Nervous System Diseases / Q000235:genetics / Q000503:physiopathology; D011954:Receptors, Dopamine / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
D011954:Receptors, Dopamine; D004298:Dopamine