Disadvantageous effects of nonsteroidal anti-inflammatory drugs on the alimentary tract.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequently recommended pharmaceutical agents worldwide. These drugs are known to damage the gastric and duodenal mucosa and also esophagus, small and large intestine mucosa. Severe complications are thought to develop in 1-2% patients after the 3-month treatment with NSAIDs. The most severe complications include erosions, ulceration accompanied by bleeding and perforation. These severe adverse reactions may occur in patients without any complaints. The factors of increased risk of complications during NSAIDs therapy are well known. The most important are: morbus ulcerosus disease, above 60 years of age, larger doses of NSAIDs, simultaneous steroid therapy, anticoagulants and Helicobacter pylori infection. NSAIDs may cause strictures and enteropathy in small intestine; and may exacerbate already existing diseases of the large bowel or also cause strictures. So, before NSAIDs prescribing one should take into account all possible harmful effects and identify the patients who are particularly at risk.
Cichoz-Lach
Halina
H
Department of Gastroenterology, Medical University of Lublin.
Celiński
Krzysztof
K
D015746:Abdominal Pain / Q000139:chemically induced; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D004064:Digestive System / Q000187:drug effects*; D004415:Dyspepsia / Q000139:chemically induced; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D010437:Peptic Ulcer / Q000139:chemically induced; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal