Does neurofilament phosphorylation regulate axonal transport?
Phosphorylation of neurofilaments has long been considered to regulate their axonal transport rate and, in doing so, to provide stability to mature axons. Interpretation of data recently obtained following C-terminal deletion experiments has prompted a challenge to this hypothesis. We present evidence that these deletion studies remain consistent with, rather than refute, a role for C-terminal phosphorylation in regulation of neurofilament axonal transport.
Shea
Thomas B
TB
Center for Cellular Neurobiology and Neurodegeneration Research, Departments of Biological Sciences and Biochemistry, University of Massachusetts (Lowell), One University Avenue, Lowell, MA 01854, USA. thomas_shea@uml.edu
Jung
Cheolwha
C
Pant
Harish C
HC
D000595:Amino Acid Sequence; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D051379:Mice; D016900:Neurofilament Proteins / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000201:enzymology*; D010744:Phosphoric Monoester Hydrolases / Q000187:drug effects*; D010766:Phosphorylation; D021122:Protein Subunits / Q000378:metabolism; D017384:Sequence Deletion
D004791:Enzyme Inhibitors; D016900:Neurofilament Proteins; D021122:Protein Subunits; D010744:Phosphoric Monoester Hydrolases