Localization of a novel autosomal recessive non-syndromic hearing impairment locus (DFNB38) to 6q26-q27 in a consanguineous kindred from Pakistan.
For autosomal recessive nonsyndromic hearing impairment over 30 loci have been mapped and 19 genes have been identified. DFNB38, a novel locus for autosomal recessive nonsyndromic hearing impairment, was localized in a consanguineous Pakistani kindred to 6q26-q27. The affected family members present with profound prelingual sensorineural hearing impairment and use sign language for communications. Linkage was established to microsatellite markers located on chromosome 6q26-q27 (Multipoint lod score 3.6). The genetic region for DFNB38 spans 10.1 cM according to the Marshfield genetic map and is bounded by markers D6S980 and D6S1719. This genetic region corresponds to 3.4 MB on the sequence-based physical map.
Ansar
Muhammad
M
Department of Biological Sciences, Quaid-I-Azam University Islamabad, Pakistan.
Ramzan
Mohammad
M
Pham
Thanh L
TL
Yan
Kai
K
Jamal
Syed Muhammad
SM
Haque
Sayedul
S
Ahmad
Wasim
W
Leal
Suzanne M
SM
D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D003241:Consanguinity; D003638:Deafness / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D005819:Genetic Markers; D006720:Homozygote; D006801:Humans; D008126:Lod Score; D008297:Male; D010154:Pakistan; D010375:Pedigree; D011995:Recombination, Genetic
D005819:Genetic Markers