title: Tissue plasminogen activator for the treatment of intraabdominal abscesses in a neonate.
abstract: Fibrinolytic agents have been used successfully in the management of loculated empyema; however, their use in the treatment of intraabdominal abscesses is limited. The authors describe the case of a 4-week-old girl with intraabdominal abscesses secondary to intestinal perforation that were not amenable to percutaneous drainage, but were managed successfully with intracavitary administration of tissue-plasminogen activator. This case represents the first report in a human, in which tissue-plasminogen activator was used to facilitate percutaneous drainage of an intraabdominal abscess. It is also the first time a fibrinolytic agent has been used for this purpose in a child.
authors.affiliation: Division of Pediatric General Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Ivan R
authors.initials: IR
authors.lastname: Diamond
authors.forename: Paul W
authors.initials: PW
authors.lastname: Wales
authors.forename: Bairbre
authors.initials: B
authors.lastname: Connolly
authors.forename: Ted
authors.initials: T
authors.lastname: Gerstle
mesh_terms: D018784:Abdominal Abscess / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D003968:Diarrhea, Infantile / Q000150:complications; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007077:Ileal Diseases / Q000150:complications / Q000601:surgery; D007082:Ileum / Q000601:surgery; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D007416:Intestinal Perforation / Q000150:complications / Q000601:surgery; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator