[Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios].
OBJECTIVE
To investigate the relationship between two polymorphisms (Intronic VNTR and 5-HTTLPR) of the serotonin transporter gene and schizophrenia.


METHODS
A set of 314 schizophrenic trio samples collected from Shanghai, Xi'an and Jilin regions of China independently was subjected to analysis of the polymorphisms by transmission/disequilibrium test(TDT).


RESULTS
No significantly preferential transmission of any allele was detected from both polymorphisms investigated.


CONCLUSIONS
The results suggest that the serotonin transporter gene is unlikely to have a major contribution to susceptibility to schizophrenia in Han Chinese population.
Sun
Wei-wei
WW
Bio-X Life Science Research Center, Shanghai Jiaotong University, Shanghai, 200030 PR China.
Fan
Jin-bo
JB
Qian
Xue-qing
XQ
Tang
Jun-xia
JX
Xing
Yang-lin
YL
Shi
Jian-guo
JG
Zhu
Shao-min
SM
Liu
Hui-jun
HJ
Gu
Niu-fan
NF
Feng
Guo-yin
GY
He
Lin
L
D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics; D009679:Nuclear Family; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
D050486:Serotonin Plasma Membrane Transport Proteins