Leptomeningeal metastases from recurrent squamous cell cancer of the skin.
We report two patients with leptomeningeal metastases from squamous cell cancer of the skin. In one patient cauda equina metastases appeared 6 years after initial presentation; the tumor from radical neck dissection demonstrated perineural invasion suggesting a possible route for subarachnoid dissemination. The other patient presented 2 years after initial diagnosis with confusion and cranial nerve seven and twelve palsies. Both patients died from complications of leptomeningeal metastases.
Begemann
Martin
M
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. begemanm@mskcc.org
Rosenblum
Marc K
MK
Loh
John
J
Kraus
Dennis
D
Raizer
Jeffrey J
JJ
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D002420:Cauda Equina / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000166:cytology; D017809:Fatal Outcome; D005682:Gadolinium; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000556:secondary*; D008875:Middle Aged; D037981:Neck Dissection; D010524:Peripheral Nervous System Neoplasms / Q000175:diagnosis / Q000473:pathology; D011379:Prognosis; D012878:Skin Neoplasms / Q000473:pathology*
D005682:Gadolinium