Identification of two new members of the CSMD gene family.
CSMD1 is a putative suppressor of squamous cell carcinomas mapping to human chromosomal region 8p23. We have cloned two new members of this gene family, CSMD2 and CSMD3. The three CSMD proteins have very similar structures, each consisting of 14 CUB domains separated from one another by a sushi domain, an additional uninterrupted array of sushi domains, a single transmembrane domain, and a short cytoplasmic tail. CUB and sushi domains are thought to be sites of protein-protein or protein-ligand interactions, suggesting that CSMD proteins are either transmembrane receptors or adhesion proteins. The cytoplasmic tail sequences are highly conserved within the vertebrate lineage. CSMD2 maps to a chromosomal region that may contain a suppressor of oligodendrogliomas, yet its expression is elevated in some head and neck cancer cell lines. Functional overlap between the CSMD1 and the CSMD2 proteins may modify the phenotype resulting from the loss of either protein in tumors.
Lau
Wei Ling
WL
Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, Box 8115, 517 S. Euclid Avenue, St. Louis, MO 63110, USA.
Scholnick
Steven B
SB
D000595:Amino Acid Sequence; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D016415:Sequence Alignment
C477879:CSMD2 protein, human; C477878:CSMD3 protein, human; D008565:Membrane Proteins