title: [Clinical study on chitosan in curing irreducible anterior disc displacement of tempormandibular joint].
abstract: OBJECTIVE
  To evaluate the clinical efficacy of intra-articular injection with 2% chitosan as a treatment for irreducible anterior disc displacement of the TMJ.
  
  
  METHODS
  Total 30 patients with irreducible anterior disc displacement were divided into two groups according to quasi-randomizaion. The patients in test group received intra-articular injection with 1.0 ml of 2% chitosan into upper cavities of the suffered joints, in control group with 12.5 mg of prednisolone. The patients were followed up at the 1st day and 14th day after injection and the maximal mouth opening was measured.
  
  
  RESULTS
  The maximal mouth opening at 14th day was (36.73 +/- 4.69) mm in test group, with 11.73 mm increase from baseline; and (28.53 +/- 5.81) mm in control group, with 3.86 mm increase, respectively. The increase of maximal mouth opening in test group was significantly higher than that of control group (P < 0.05).
  
  
  CONCLUSIONS
  Chitosan is an effective biomaterial in curing irreducible anterior disc displacement of TMJs.
authors.affiliation: Department of Stomatology, Medical College of Jinan University, Guangzhou 510632, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Liu
authors.forename: Zhao
authors.initials: Z
authors.lastname: Tang
authors.forename: Wenbing
authors.initials: W
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D001672:Biocompatible Materials / Q000008:administration & dosage; D002686:Chitin / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D048271:Chitosan; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage; D016059:Range of Motion, Articular; D019224:Temporomandibular Joint Disc / Q000293:injuries / Q000473:pathology*; D013705:Temporomandibular Joint Disorders / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D002686:Chitin; D048271:Chitosan; D011239:Prednisolone