title: [The role of nutritional status on serum immunoglobulins, body weight and postoperative infectious-related complications in patients with Crohn's disease receiving perioperative parenteral nutrition].
abstract: OBJECTIVE
  To evaluate the role of nutritional status on serum immunoglobulins, body weight and postoperative infectious-related complications in patients with Crohn's disease receiving perioperative parenteral nutrition (PN).
  
  
  METHODS
  32 patients with Crohn's disease receiving perioperative parenteral nutrition in our department between 1984 and 1994 were enrolled in this survey. 16 patients with loss of body weight in the range of 15%-30% were assigned to the malnutrition group, the other 16 patients with normal weight or loss of body weight less than 15% to the control group. Serum IgM, IgG and IgA levels were measured before and after PN by enzyme-linked immunosorbent assays. Liver function, body weight changes and postoperative complications were also analyzed.
  
  
  RESULTS
  IgM levels were elevated before PN in both groups [control group: (133 +/- 16) mg/dl, malnutrition group: (139 +/- 41) mg/dl; normal value: (110 +/- 35) mg/dl; P = 0.04], decreased to normal value [(105 +/- 29) mg/dl, P = 0.02] in the malnutrition group while having no obvious changes in the control group [(129 +/- 13) mg/dl, P = 0.34]. No significant changes in concentrations of IgG and IgA were found (P in the range of 0.20-0.57). The average weight gain was 1.862 kg in malnutrition group [before PN: (45.8 +/- 8.9) kg, after PN: (48.0 +/- 8.8) kg; P = 0.005] and no significant changes in the control group [before PN: (55.6 +/- 6.1) kg, after PN: (56.3 +/- 6.0) kg; P = 0.46]. There was an increase in infectious complications in the control group (control group: 4 cases, 25%, malnourished group: 2 cases, 12.5%; P = 0.13).
  
  
  CONCLUSIONS
  Perioperative parenteral nutrition ameliorated the humoral immunity, increased the body weight in patients with obvious malnutrition, whereas it had little value for those without or with mild malnutrition.
authors.affiliation: Department of Surgery, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.
authors.forename: Guo-xiang
authors.initials: GX
authors.lastname: Yao
authors.forename: Xiu-rong
authors.initials: XR
authors.lastname: Wang
authors.forename: Zhu-ming
authors.initials: ZM
authors.lastname: Jiang
authors.forename: Si-yuan
authors.initials: SY
authors.lastname: Zhang
authors.forename: En-ling
authors.initials: EL
authors.lastname: Ma
authors.forename: An-ping
authors.initials: AP
authors.lastname: Ni
mesh_terms: D000328:Adult; D000368:Aged; D001835:Body Weight; D003424:Crohn Disease / Q000276:immunology / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D008297:Male; D044342:Malnutrition / Q000209:etiology; D008875:Middle Aged; D009752:Nutritional Status; D010288:Parenteral Nutrition; D011014:Pneumonia / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology
chemical_list: D007136:Immunoglobulins