title: Meloxicam and selective COX-2 inhibitors in the management of pain in the palliative care population.
abstract: This paper discusses the treatment of pain in the palliative care patient, specifically the use of meloxicam and recent advances in agents with cyclooxygenase-2 (COX-2) selectivity. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that preferentially inhibits COX-2 more than cyclooxygenase-1 (COX-1), especially at low doses, thereby offering advantages over traditional nonselective NSAIDs. New COX-2 selective agents are discussed, including valdecoxib, parecoxib, etoricoxib, and COX-189.
authors.affiliation: UPMC Presbyterian Pain Medicine, Department of Anesthesiology, Pittsburgh, Pennsylvania, USA.
authors.forename: Howard S
authors.initials: HS
authors.lastname: Smith
authors.forename: Whitney
authors.initials: W
authors.lastname: Baird
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D004008:Diclofenac / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D000077613:Etoricoxib; D006801:Humans; D007555:Isoxazoles / Q000627:therapeutic use; D000077239:Meloxicam; D009930:Organic Chemicals / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D010166:Palliative Care / Q000379:methods*; D011725:Pyridines / Q000627:therapeutic use; D013449:Sulfonamides / Q000627:therapeutic use; D013450:Sulfones / Q000627:therapeutic use; D013843:Thiazines / Q000494:pharmacology / Q000627:therapeutic use*; D013844:Thiazoles / Q000494:pharmacology / Q000627:therapeutic use*; D000096926:Benzenesulfonamides
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D004008:Diclofenac; D000077613:Etoricoxib; D007555:Isoxazoles; D000077239:Meloxicam; D009930:Organic Chemicals; D011725:Pyridines; D013449:Sulfonamides; D013450:Sulfones; D013843:Thiazines; D013844:Thiazoles; C406224:valdecoxib; D000096926:Benzenesulfonamides; C409945:parecoxib; C473384:lumiracoxib