title: Fast drug stability determination by LC variable-parameter kinetic experiments.
abstract: Variable-parameter kinetic experiments were carried out using HPLC as analytical instrument. The hydrolysis of aspirin was followed both at variable-temperature and at variable-pH conditions. The peak areas relative to salicylic acid were processed by direct fit to a mathematical model and/or by differential method obtaining, by single experiments, the values of the apparent rate constant in the whole range of temperature and pH studied. The results, although the discontinuity of this kind of analysis, are in agreement with those obtained by constant-parameter kinetics but saving experimental time.
authors.affiliation: Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica, Università di Messina, Salita Sperone 31, Villaggio S. Agata, 98166 Messina, Italy. alibrandi@chem.unime.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Alibrandi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Coppolino
authors.forename: Santi
authors.initials: S
authors.lastname: D'Aliberti
authors.forename: Rita
authors.initials: R
authors.lastname: Ficarra
authors.forename: Norberto
authors.initials: N
authors.lastname: Micali
authors.forename: Antonino
authors.initials: A
authors.lastname: Villari
mesh_terms: D001241:Aspirin / Q000032:analysis / Q000378:metabolism; D002853:Chromatography, Liquid / Q000379:methods; D004355:Drug Stability; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D001241:Aspirin