title: An uncertainty principle in chromosome positioning.
abstract: Chromosomes are non-randomly positioned in the mammalian interphase nucleus. It is not known how patterns of chromosome positions are established or to what degree spatial arrangements of chromosomes change during the cell cycle, especially during mitosis. Two reports have applied in vivo microscopy to track chromosomes in space and time. The results highlight the inherently imperfect and probabilistic nature of chromosome positioning in the cell nucleus.
authors.affiliation: National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Parada
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Roix
authors.forename: Tom
authors.initials: T
authors.lastname: Misteli
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D002455:Cell Division / Q000235:genetics; D002503:Centromere / Q000502:physiology; D002843:Chromatin / Q000502:physiology; D045584:Chromosome Positioning / Q000502:physiology*; D036681:Fluorescence Recovery After Photobleaching; D006801:Humans; D007399:Interphase / Q000235:genetics; D042581:Intranuclear Space / Q000502:physiology*; D008164:Luminescent Proteins / Q000032:analysis; D008856:Microscopy, Fluorescence; D008938:Mitosis / Q000235:genetics; D008954:Models, Biological
chemical_list: D002843:Chromatin; D008164:Luminescent Proteins