title: Low serum apolipoprotein AI levels in amyloidosis related to familial Mediterranean fever.
abstract: Amyloidosis (A) related to familial Mediterranean fever (FMF) causes serious morbidity and mortality in children. Our study evaluates serum levels of apolipoprotein (Apo) AI, AII, B, and E and Apo AII/AI ratios as a non-invasive diagnostic tool for amyloidosis in children with FMF and FMF-A. Results were compared with those of patients with childhood nephrotic syndrome (NS) and healthy children (controls). Significantly lower serum levels of Apo AI (90.20+/-28.30 mg/dl) were documented in patients with FMF-A than in all other groups (FMF 126.89+/-51.07 mg/dl, NS 140.38+/-33.73 mg/dl, and controls 134.67+/-12.73 mg/dl) ( P<0.01). Diagnostic sensitivity, specificity, and predictive value for this test were 85%, 80%, and 85%, respectively. Apo AII/AI ratio results were essentially equal in all groups ( P>0.05). It is concluded that a decreased Apo AI serum level, but not Apo AII/AI ratio, is a useful, non-invasive test for the early diagnosis of FMF-A in children.
authors.affiliation: Department of Pediatrics, Ondokuz Mayis University, 55139 Samsun, Turkey. iislek@omu.edu.tr
authors.forename: Ismail
authors.initials: I
authors.lastname: Işlek
authors.forename: Tülin
authors.initials: T
authors.lastname: Simşek
authors.forename: Esra
authors.initials: E
authors.lastname: Baskin
authors.forename: Behçet
authors.initials: B
authors.lastname: Simşek
authors.forename: Sükrü
authors.initials: S
authors.lastname: Küçüködük
authors.forename: Abdülkerim
authors.initials: A
authors.lastname: Bedir
authors.forename: Ayşin
authors.initials: A
authors.lastname: Bakkaloğlu
authors.forename: Nesrin
authors.initials: N
authors.lastname: Beşbaş
authors.forename: Rezzan
authors.initials: R
authors.lastname: Topaloğlu
authors.forename: Seza
authors.initials: S
authors.lastname: Ozen
authors.forename: Umit
authors.initials: U
authors.lastname: Saatçi
mesh_terms: D000293:Adolescent; D000686:Amyloidosis / Q000097:blood* / Q000175:diagnosis*; D016632:Apolipoprotein A-I / Q000097:blood*; D016633:Apolipoprotein A-II / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D001057:Apolipoproteins E / Q000097:blood; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D010505:Familial Mediterranean Fever / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood / Q000175:diagnosis; D012680:Sensitivity and Specificity
chemical_list: D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001055:Apolipoproteins B; D001057:Apolipoproteins E; D015415:Biomarkers