title: Nifekalant hydrochloride, a novel class III antiarrhythmic agent, suppressed postoperative recurrent ventricular tachycardia in a patient undergoing coronary artery bypass grafting and the Dor approach.
abstract: A patient with 3-vessel coronary artery disease and left ventricular aneurysm underwent coronary artery bypass grafting combined with the Dor approach. Five days later, ventricular tachycardia following short-coupled ventricular premature contractions suddenly occurred and was not responsive to class IB drugs (lidocaine and mexiletine), requiring frequent electrical cardioversion. After the administration of a novel class III drug, nifekalant hydrochloride, this electrical storm of ventricular tachycardia was completely suppressed together with the disappearance of ventricular premature contractions. Nifekalant hydrochloride (MS-551), a pure K(+) channel blocker, might be effective for postoperative recurrent ventricular tachyarrhythmias that are refractory to other antiarrhythmic agents.
authors.affiliation: The Cardiovascular Institute Hospital, Tokyo, Japan. saharam-tky@umin.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Sahara
authors.forename: Kouichi
authors.initials: K
authors.lastname: Sagara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamashita
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iinuma
authors.forename: Long-Tai
authors.initials: LT
authors.lastname: Fu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000145:classification / Q000627:therapeutic use*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D004351:Drug Resistance; D004554:Electric Countershock; D004562:Electrocardiography; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008801:Mexiletine / Q000627:therapeutic use; D026902:Potassium Channel Blockers / Q000627:therapeutic use*; D011744:Pyrimidinones / Q000627:therapeutic use*; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology* / Q000628:therapy
chemical_list: D000889:Anti-Arrhythmia Agents; D026902:Potassium Channel Blockers; D011744:Pyrimidinones; D008801:Mexiletine; C076259:nifekalant; D008012:Lidocaine