Long coiled-coil proteins and membrane traffic.
Protein transport between organelles is mediated by vesicles which must accurately dock and fuse with appropriate compartments. Over the past several years a large number of long coiled-coil proteins have been identified on the Golgi and on endosomes, mostly as auto-antigens in autoimmune disorders. Based on their restricted intracellular distributions and their predicted rod-like structure, these proteins have been proposed to play a role in tethering vesicles to target organelles prior to fusion. However, such proteins may also play a structural role, for example as components of a Golgi matrix, or as scaffolds for the assembly of other factors important for fusion. This review will examine what is known about the function of these large coiled-coil proteins in membrane traffic.
Gillingham
Alison K
AK
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK. sean@mrc-lmb.cam.ac.uk
Munro
Sean
S
D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000502:physiology; D011992:Endosomes / Q000502:physiology; D006056:Golgi Apparatus / Q000502:physiology; D006801:Humans; D026901:Membrane Transport Proteins / Q000502:physiology*; D021381:Protein Transport
D026901:Membrane Transport Proteins