Synthesis of 2'-O-deuteriomethyl ribonucleosides Gm-d3, Am-d3, Um-d3 and Cm-d3.
The synthesis of 2'-O-deuteriomethyl ribonucleosides by iodomethane-d3 (99.5 + atom % D) deuteriomethylation of 3',5'-O-tetra(isopropyldisiloxane)-diyl nucleosides, followed by deprotection, is described.
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Department of Medicinal Chemistry, University of Utah, 30 S 2000 E, Salt Lake City, UT 84112, USA.
D002851:Chromatography, High Pressure Liquid; D003903:Deuterium / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D012313:RNA / Q000138:chemical synthesis / Q000737:chemistry; D020871:RNA Stability; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D012263:Ribonucleosides; D012313:RNA; D003903:Deuterium