title: Determination of the CCR2-64I/CCR5-59653T haplotype linkage disequilibrium in a sample of Polish population.
abstract: It has been reported that different polymorphisms in the regulatory regions of CCR5 and in the CCR2 gene of the chemokine receptors are associated with AIDS. We decided to determine the congruence between CCR5-59653T and CCR2-64I alleles in a group of 281 persons. Frequencies of combined CCR5-59653T and CCR2-64I haplotypes were examined in a group of 281 persons. Among 281 individuals 26 (9.3%) and 24 (8.5%) respectively were carriers of the CCR5-59653T and the CCR2-64I alleles. We also found that 24 persons (8.5%) were carriers of combined CCR2-64I/CCR5-59653T allele. The calculation of the congruence revealed that 92.0% of individuals exhibited the same genotype for both CCR2-64I and CCR5-59653T polymorphisms. Our results confirm that linkage between CCR5-59653T and CCR2-64I alleles is not absolute.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Medical Sciences, 60-781 Poznan, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Lewandowska
authors.forename: W H
authors.initials: WH
authors.lastname: Trzeciak
authors.forename: P P
authors.initials: PP
authors.lastname: Jagodzinski
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics; D001483:Base Sequence; D005828:Genetics, Population; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008969:Molecular Sequence Data; D011044:Poland; D011110:Polymorphism, Genetic; D054390:Receptors, CCR2; D019713:Receptors, CCR5 / Q000235:genetics*; D019707:Receptors, Chemokine / Q000235:genetics*
chemical_list: C515334:CCR2 protein, human; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019707:Receptors, Chemokine