title: Separation of aminoalkanephosphonic acid enantiomers by indirect UV detection capillary electrophoresis with application of cyclodextrins.
abstract: Indirect UV detection capillary electrophoresis (CE) was used for the separation of aminoalkanephosphonic acid (AP) enantiomers by applying commercially available cyclodextrins as chiral discriminators. The results show that the separation of the enantiomers depends on pH of the background electrolyte, the molar ratio of cyclodextrin to aminophosphonic acid, and on the type of the applied chiral selector. Optimization of process conditions allowed enantiomeric baseline separation or partial separation of 12 out of 14 alpha-aminophosphonic acids studied. This type of CE might therefore be successfully used for routine determination of enantiomeric purity of aminophosphonic acids.
authors.affiliation: Institute of Organic Chemistry, Biochemistry and Biotechnology, Wroclaw University of Technology, Wroclaw, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Rudzińska
authors.forename: Piotr
authors.initials: P
authors.lastname: Wieczorek
authors.forename: Paweł
authors.initials: P
authors.lastname: Kafarski
mesh_terms: D000588:Amines / Q000302:isolation & purification; D003505:Cyclodextrins; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D063065:Organophosphonates / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D003505:Cyclodextrins; D063065:Organophosphonates