title: Intracranial giant cell arteritis with fatal middle cerebral artery territory infarct.
abstract: A 37 year-old man who developed a fatal middle cerebral territory infarct was found at autopsy, to have widespread granulomatous angiitis involving meningeal and intracranial--extracerebral vessels but not intracerebral vessels or other extra-cranial vessels. The findings are unique and overlap with those of granulomatous angiitis of the nervous system (GANS) and classic giant cell arteritis (GCA). A possible precipitant for this devastating illness was a recent Chlamydia infection. The salient clinical and pathologic differences between GANS and GCA of the nervous system are discussed.
authors.affiliation: Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
authors.forename: L
authors.initials: L
authors.lastname: Browne
authors.forename: O
authors.initials: O
authors.lastname: Hardiman
authors.forename: H
authors.initials: H
authors.lastname: O'Dwyer
authors.forename: M
authors.initials: M
authors.lastname: Farrell
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D013700:Giant Cell Arteritis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology*; D020765:Intracranial Arterial Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D008218:Lymphocytosis / Q000134:cerebrospinal fluid; D008297:Male