title: Lack of association of the plasminogen activator inhibitor-1 4G/5G promoter polymorphism with cardiovascular disease in the elderly.
abstract: Elevated circulating plasminogen activator inhibitor-1 (PAI-1) may increase risk of cardiovascular disease (CVD). The 4G allele of the 4G/5G PAI-1 promoter polymorphism is associated with higher levels of PAI-1. We examined the association of PAI-1 4G/5G genotype and CVD events in the elderly participants of the Cardiovascular Health Study (CHS). We measured 4G/5G genotype in a nested case-control study within the CHS. Cases included incident angina, myocardial infarction (MI), and stroke. 4G/5G genotype was not found to be associated with markers of fibrinolysis or CVD risk in the selected elderly cohort. There were no differences in genotype frequencies by case-control status (5G/5G frequency 16-22%; chi2P= 0.07). The 5G allele was not associated with incident CVD events when individuals with at least one 5G allele were compared to 4G/4G homozygotes. The presence of at least one 4G allele was likewise not associated with incident CVD when those with 4G/4G and 4G/5G genotypes were compared to 5G/5G homozygotes. Our results suggest that the PAI-1 4G/5G promoter polymorphism is not associated CVD risk factors or incident CVD events in the elderly.
authors.affiliation: Department of Pathology, College of Medicine, University of Vermont, Burlington, Vermont 05446, USA.
authors.forename: P
authors.initials: P
authors.lastname: Crainich
authors.forename: N S
authors.initials: NS
authors.lastname: Jenny
authors.forename: Z
authors.initials: Z
authors.lastname: Tang
authors.forename: A M
authors.initials: AM
authors.lastname: Arnold
authors.forename: L H
authors.initials: LH
authors.lastname: Kuller
authors.forename: T
authors.initials: T
authors.lastname: Manolio
authors.forename: A R
authors.initials: AR
authors.lastname: Sharrett
authors.forename: R P
authors.initials: RP
authors.lastname: Tracy
mesh_terms: D000368:Aged; D000483:Alleles; D044383:Black People; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000235:genetics; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012306:Risk; D044465:White People
chemical_list: D017395:Plasminogen Activator Inhibitor 1