Stimulation of mouse resistance to bacterial infection with muramyl dipeptide glycoside.
We studied the capacity of 9 new muramyl dipeptide glycosides to stimulate mouse resistance to experimental sepsis induced by intraperitoneal injection of salmonella typhimurium culture. Preventive intraperitoneal injections of muramyl dipeptide beta-glycosides better improved survival of infected animals compared to the original (unmodified) muramyl dipeptide and muramyl dipeptide alpha-glycosides. The most effective drug muramyl dipeptide beta-heptylglycoside injected during sepsis development also reduced animal mortality, decreased bacterial contamination of the viscera, and increased phagocytic activity of peritoneal macrophages in infected animals.
Kalyuzhin
O V
OV
Laboratory of Cellular Immunopathology and Biotechnology, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow. kalyuzhin@mtu-net.ru
Kalina
N G
NG
Bashtanenko
A F
AF
Shkalev
M V
MV
Kuzovlev
F N
FN
Kalyuzhin
V V
VV
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D001424:Bacterial Infections / Q000276:immunology*; D007113:Immunity, Innate / Q000502:physiology*; D017737:Macrophages, Peritoneal / Q000276:immunology / Q000378:metabolism; D051379:Mice; D012486:Salmonella typhimurium / Q000276:immunology / Q000378:metabolism; D018805:Sepsis; D015996:Survival Rate
D000119:Acetylmuramyl-Alanyl-Isoglutamine