[Effect of chloroform and ether narcosis on the activity of basic carboxypeptidases in the hypothalamic-pituitary-adrenal axis in rats].
It is discovered that chloroform narcosis does not influence on carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase activity in the rats hypothalamic-pituitary-adrenal axis. Ether narcosis provokes an increase of PMSF-inhibited carboxypeptidase activity in the pituitary body approximately in 8 times and carboxypeptidase H activity in hypothalamus by 29 percents in comparison with the intact animals. It is supposed that at research neuropeptides and their metabolism enzymes and especially the answer to a stress chloroform narcosis would be the better anaesthesia method than ether narcosis.
Vernigora
A N
AN
Penza State Pedagogical University, Russia.
Gengin
M T
MT
Mukhina
E S
ES
Mikhaĭlova
O E
OE
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D043423:Carboxypeptidase H / Q000378:metabolism; D002268:Carboxypeptidases / Q000378:metabolism*; D002725:Chloroform / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004986:Ether / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000201:enzymology*; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000201:enzymology*; D051381:Rats
D018685:Anesthetics, Inhalation; D004791:Enzyme Inhibitors; D004986:Ether; D010664:Phenylmethylsulfonyl Fluoride; D002725:Chloroform; D002268:Carboxypeptidases; D043423:Carboxypeptidase H