[Effect of metoprolol CR/XL on remodeling of the heart and cardiac rhythm disturbances after myocardial infarction in patients with chronic heart failure].
Metoprolol succinate was given to 60 patients with class I-III heart failure and ejection fraction <45% after myocardial infarction. Forty seven patients (mean age 59.3+/-9.8 years) completed 6 months of therapy. Dynamics of ventricular arrhythmias was assessed by Holter ECG monitoring, registration of parameters of high resolution ECG and heart rate variability. and echocardiography. Functional class of heart failure decreased in 93%, that of angina - in 55% of patients. Antiarrhythmic effect was achieved in 72% of patients. This was associated with diminishment of left ventricular volumes and increased ejection fraction, shortening of TotQRSF, and improvement of autonomic regulation of cardiac action. No dynamics of myocardial contractility and electrophysiological remodeling occurred in patients without antiarrhythmic effect.
Syrkin
A L
AL
Poltavskaia
M G
MG
Shumilova
K M
KM
Ivanov
G G
GG
Churganova
L Iu
LIu
Sheianov
M V
MV
Gavril'eva
S A
SA
D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications; D016896:Treatment Outcome; D020257:Ventricular Remodeling / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; D008790:Metoprolol