title: Iris and anterior chamber involvement in acute lymphoblastic leukemia.
abstract: The authors describe a 6-year-old child, with a history of acute lymphoblastic leukemia, who presented with leukemic infiltration of the anterior segment of one eye mimicking anterior uveitis. After tissue diagnosis, administration of radiation therapy to the affected eye resulted in dramatic improvement of the condition. Involvement of the iris and anterior chamber is a recognized but unusual manifestation of leukemia. In the absence of systemic relapse, local radiation therapy without chemotherapy is highly effective, although the prognosis in these patients may be guarded.
authors.affiliation: Department of Opthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Sanjay V
authors.initials: SV
authors.lastname: Patel
authors.forename: David C
authors.initials: DC
authors.lastname: Herman
authors.forename: Peter M
authors.initials: PM
authors.lastname: Anderson
authors.forename: Naser J
authors.initials: NJ
authors.lastname: Al-Zein
authors.forename: Helmut
authors.initials: H
authors.lastname: Buettner
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D015811:Iris Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000473:pathology*; D011379:Prognosis; D014605:Uveitis / Q000175:diagnosis* / Q000473:pathology