title: [Telomerase expression in various lesions of adrenal cortex].
abstract: OBJECTIVE
  To investigate the expression of telomerase in various lesions of adrenal cortex.
  
  
  METHODS
  By autoradiography-based telomeric repeat amplification protocol, telomerase expression was detected in 36 samples of adrenocortical lesions, including 29 cases adrenocortical adenoma (8 Cushing's syndrome, 17 aldosteronism and 4 nonfunctional adenomas), 5 cases of hyperplasia of adrenal cortex (presented with Chushing' syndrome), 2 cases adrenocortical carcinoma, and 4 samples of normal adrenal cortex.
  
  
  RESULTS
  Of the 40 samples, 2 cases of adrenocortical carcinomas had telomerase expression, and the others had no telomerase expression detected.
  
  
  CONCLUSIONS
  No significant telomerase expression was found among different endocrine functional benign adrenocortical lesions. Telomerase expression may be used as an important marker of malignant adrenocortical tumor.
authors.affiliation: Department of Urology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China. Maoqz@csc.pumch.ac.cn
authors.forename: Quan-zong
authors.initials: QZ
authors.lastname: Mao
authors.forename: Shi
authors.initials: S
authors.lastname: Rong
authors.forename: Jin-hai
authors.initials: JH
authors.lastname: Fan
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Ji
authors.forename: Han-zhong
authors.initials: HZ
authors.lastname: Li
authors.forename: Mei-fu
authors.initials: MF
authors.lastname: Zang
mesh_terms: D000302:Adrenal Cortex / Q000201:enzymology*; D000306:Adrenal Cortex Neoplasms / Q000201:enzymology*; D018246:Adrenocortical Adenoma / Q000201:enzymology; D014408:Biomarkers, Tumor / Q000032:analysis; D003480:Cushing Syndrome / Q000201:enzymology; D006801:Humans; D019098:Telomerase / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D019098:Telomerase