New and emerging therapies for short bowel syndrome in children.
This review provides an overview of traditional as well as emerging therapies useful in the management of pediatric short bowel syndrome. Pediatric short bowel syndrome is relatively uncommon; however, when it does occur, it presents a unique challenge to medical care providers. The use of parenteral and enteral nutrition to maximize growth and enhance intestinal adaptation so as to increase absorptive surface area has been the primary focus of therapy. In recent years, the advent of pharmacologic advances, including the use of antibacterial drugs, anti-motility drugs and hormonal therapies, has had a significant impact on this condition. At times, surgery may be indicated for dealing with complications, or providing alternative therapy such as transplantation. With ongoing research, it is likely that improved pharmacologic therapy will be available for enhanced intestinal adaptation, control of gut motility, treatment of small bowel bacterial overgrowth, and treatment of rejection following small intestinal transplantation.
Vanderhoof
Jon A
JA
Department of Pediatric Gastroenterology and Nutrition, University of Nebraska Medical Center, Omaha, Nebraska 68198-5160, USA. jvanderh@unmc.edu
Young
Rosemary J
RJ
Thompson
Jon S
JS
D001419:Bacteria / Q000254:growth & development; D004750:Enteral Nutrition; D005764:Gastroesophageal Reflux / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007421:Intestine, Small / Q000637:transplantation*; D008107:Liver Diseases / Q000209:etiology; D010288:Parenteral Nutrition / Q000009:adverse effects; D018805:Sepsis / Q000209:etiology; D012778:Short Bowel Syndrome / Q000150:complications / Q000382:microbiology / Q000601:surgery / Q000628:therapy*