New benzo[g]isoquinoline-5,10-diones and dihydrothieno [2,3-b]naphtho-4,9-dione derivatives: synthesis and biological evaluation as potential antitumoral agents.
Novel antitumoral agents with quinonic structure were synthesized and evaluated for their in vitro cytotoxic activities. This study examines the cytotoxic activities of several aryl benzo[g]isoquinoline-5,10-dione derivatives and a number of aminoacyl dihydrothieno[2,3-b]naphtho-4,9-dione (DTNQ) derivatives containing amino acids in position 3 of the ring system. Compound 6 showed remarkable cytotoxic activity at submicromolar concentration not only against several human leukaemia and solid tumour cell lines, but also toward sensitive and resistant human cell lines.
Gomez-Monterrey
Isabel
I
Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli Federico II, Naples, Italy.
Campiglia
Pietro
P
Grieco
Paolo
P
Diurno
Maria Vittoria
MV
Bolognese
Adele
A
La Colla
Paolo
P
Novellino
Ettore
E
D000596:Amino Acids / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity*; D044182:Benzylisoquinolines / Q000138:chemical synthesis* / Q000633:toxicity*; D045744:Cell Line, Tumor; D006801:Humans; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000633:toxicity*
D000596:Amino Acids; D000970:Antineoplastic Agents; D044182:Benzylisoquinolines; D009285:Naphthoquinones