Successful reduced-intensity stem cell transplantation from an HLA haploidentical 3-loci-mismatched donor on the basis of fetomaternal microchimerism in a patient with advanced acute myeloid leukemia.
A 31-year-old woman with advanced acute myeloid leukemia underwent non-T-cell-depleted (TCD) peripheral blood stem cell transplantation (PBSCT) with a reduced-intensity conditioning regimen. The donor was an HLA haploidentical 3-loci-mismatched complementary sibling who had not inherited maternal HLA antigens. Long-term fetomaternal microchimerism was detected by nested polymerase chain reaction with specific primer typing. Graft-versus-host disease (GVHD) prophylaxis consisted of tacrolimus with minidose methotrexate. Durable engraftment was achieved without severe acute GVHD, and complete remission was obtained. Thus non-TCD HLA haploidentical reduced-intensity PBSCT based on fetomaternal immunological tolerance appears to be feasible. Our results have important implications in the selection of alternative donors and conditioning regimens for allogeneic hematopoietic stem cell transplantation.
Uoshima
Nobuhiko
N
Department of Internal Medicine, Matsushita Memorial Hospital, Moriguchi, Osaka, Japan. PAN08902@pas.mei.co.jp
Kamitsuji
Yuri
Y
Maruya
Etsuko
E
Saji
Hiroh
H
D000208:Acute Disease; D000328:Adult; D005260:Female; D006239:Haplotypes; D006648:Histocompatibility / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007108:Immune Tolerance; D007951:Leukemia, Myeloid / Q000628:therapy*; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D011247:Pregnancy; D012074:Remission Induction; D035781:Siblings; D018183:Transplantation Chimera; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous; D016896:Treatment Outcome