title: Early endoderm development in vertebrates: lineage differentiation and morphogenetic function.
abstract: Gastrulation of the vertebrate embryo culminates in the formation of three primary germ layers: ectoderm, mesoderm and endoderm. The endoderm contributes to the lining of the gut and the associated organs. New components of the molecular pathway for endoderm specification have been identified in the zebrafish and Xenopus. In the mouse, the activity of orthologous factors is involved with the allocation and differentiation of the definitive endoderm. Morphogenetic interactions between the endoderm and the other germ layer derivatives are critical for the morphogenesis of head structures and organogenesis of gut derivatives.
authors.affiliation: Embryology Unit, Children's Medical Research Institute, Locked Bag 23, Wentworthville, New South Wales 2145, Australia. ptam@cmri.usyd.edu.au
authors.forename: Patrick P L
authors.initials: PP
authors.lastname: Tam
authors.forename: Masami
authors.initials: M
authors.lastname: Kanai-Azuma
authors.forename: Yoshiakira
authors.initials: Y
authors.lastname: Kanai
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology; D004627:Embryonic Induction / Q000502:physiology*; D004707:Endoderm / Q000502:physiology*; D006609:High Mobility Group Proteins / Q000502:physiology; D008954:Models, Biological; D009024:Morphogenesis; D055457:Nodal Protein; D055760:SOXF Transcription Factors; D015398:Signal Transduction / Q000502:physiology*; D020825:T-Box Domain Proteins / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D014714:Vertebrates / Q000196:embryology*; D029867:Xenopus Proteins; D029961:Zebrafish Proteins
chemical_list: D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D055457:Nodal Protein; C526008:Nodal protein, mouse; D055760:SOXF Transcription Factors; D020825:T-Box Domain Proteins; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; C103966:VegT protein, Xenopus; D029867:Xenopus Proteins; D029961:Zebrafish Proteins; C491603:sox17 protein, zebrafish; C491602:sox17a protein, Xenopus; C491601:sox17b.1 protein, Xenopus