title: [Sildenafil in the treatment of pulmonary hypertension].
abstract: Pulmonary hypertension (PHT) is a rare entity that is difficult to treat. Prognosis is poor. Sildenafil, a selective inhibitor of type 5 phosphodiesterase, has been proposed among the many treatments available for primary and secondary pulmonary hypertension. We report our experience with an infant with pulmonary hypertension due to congenital mitral stenosis and persistent ductus arteriosus, who developed congestive cardiac failure with persistent PHT despite surgical correction. Conventional treatment was unsuccessful and the patient was treated with sildenafil. The clinical course was satisfactory, allowing extubation and withdrawal of vasoactive drugs; pulmonary and left atrial pressure decreased and the patient was discharged. She is currently being treated on an outpatient basis with oral sildenafil and shows satisfactory hemodynamic status. We review alternatives to conventional treatments for pulmonary hypertension with special reference to pediatrics.
authors.affiliation: Servicio de Críticos y Urgencias de Pediatría. Departamento de Pediatría. Hospital Universitario Reina Sofia. Cordoba. Spain.
authors.forename: E
authors.initials: E
authors.lastname: García Martínez
authors.forename: I
authors.initials: I
authors.lastname: Ibarra de la Rosa
authors.forename: J L
authors.initials: JL
authors.lastname: Pérez Navero
authors.forename: I
authors.initials: I
authors.lastname: Tejero Mateo
authors.forename: J F
authors.initials: JF
authors.lastname: Expósito Montes
authors.forename: J
authors.initials: J
authors.lastname: Suárez de Lezo y Cruz Conde
mesh_terms: D004374:Ductus Arteriosus, Patent / Q000150:complications; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D007223:Infant; D008946:Mitral Valve Stenosis / Q000150:complications; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate