DSLET and ACTH(4-10) increase mitotic activity of hepatocytes and suppress antibody production.
The mitotic index of hepatocytes remained unchanged after 10 intraperitoneal injections of DSLET and ACTH(4-10) in doses of 0.5, 1.5, and 5 microg/kg, but increased after injection of these substances in doses of 50 and 150 microg/kg. DSLET in doses of 5, 50, and 150 microg/kg decreased the number of antibody-producing cells in the spleen. ACTH(4-10) possessed immunosuppressive activity not only in these doses, but also in a dose of 1.5 microg/kg. As differentiated from mitotic activity of hepatocytes, the degree of immunosuppression increased with increasing the dose of test peptides.
Smakhtin
M Yu
MY
Department of Pathophysiology, Kursk State Medical University.
Konoplya
A I
AI
Sever'yanova
L A
LA
Shveinov
I A
IA
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000906:Antibodies / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D022781:Hepatocytes / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D008938:Mitosis / Q000502:physiology*; D018697:Nootropic Agents / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*
D000700:Analgesics; D000906:Antibodies; D018697:Nootropic Agents; D010446:Peptide Fragments; D004743:Enkephalin, Leucine; C034318:enkephalin, Ser(2), Leu(5), Thr(6)-; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10)