[Effect of ultra-low dose of ionizing radiation on the surface potential of erythrocytes].
Effect of ionizing radiation in ultralow dose (5 microGy) on responses of erythrocyte electrophoretic motility (EPM) as a result of adrenoreceptor ligands binding (0.01-100 microM) has been investigated. The opposite directional EPM responses to agonists (adrenaline, isoprenaline) and antagonist (propranolol) of beta-adrenoreceptors was shown. At that, EPM response to the radiation coincides both with the direction and value of acting the beta-adrenoreceptor agonists depressing EPM. The EPM response to a combined action of beta-adrenoreceptors antagonist, propranolol (10 microM), and ionizing radiation is additive. The above listed is capable to evidence about the essential role of adrenoreceptors at formation of erythrocyte membrane surface charge under action of ionizing radiation in ultralow doses.
Zhirnov
V V
VV
Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine, Kyiv.
Kalashnikova
L E
LE
Gaviĭ
V N
VN
D000200:Action Potentials; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004837:Epinephrine / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000502:physiology / Q000528:radiation effects*; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011839:Radiation, Ionizing; D011941:Receptors, Adrenergic / Q000502:physiology
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011941:Receptors, Adrenergic; D011433:Propranolol; D007545:Isoproterenol; D004837:Epinephrine