title: Expression of estrogen receptor-beta in normal mammary and tumor tissues: is it protective in breast carcinogenesis?
abstract: Using messenger RNA (mRNA) in situ hybridization, we investigated estrogen receptor-beta (ERbeta) mRNA levels in normal mammary, benign breast tumor (BBT), breast cancer (BC), and metastatic lymph node tissues to verify the role of ERbeta in BC development and progression. ERbeta expression was significantly decreased in BC and metastatic lymph node tissues compared with normal mammary and BBT tissues (p < 0.01). The intensity and extent of ERbeta mRNA signals were also significantly lower in BC and metastatic lymph node tissues than in the normal mammary and BBT tissues (p < 0.01). An inverse relationship was found between ERbeta mRNA level and both histologic grade (p = 0.091) and progesterone receptor expression (p = 0.052) with marginal significance, but no significant association was noted between ERbeta expression in cancer tissues and the other clinico-pathologic data. The 3-year distant relapse-free survival probability was found to be independent of ERbeta expression. Collectively, ERbeta mRNA decreases in the process of BC development, but seems to be associated with poor differentiation.
authors.affiliation: Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea. bwpark@yumc.yonsei.ac.kr
authors.forename: Byeong-Woo
authors.initials: BW
authors.lastname: Park
authors.forename: Ki-Suk
authors.initials: KS
authors.lastname: Kim
authors.forename: Min-Kyu
authors.initials: MK
authors.lastname: Heo
authors.forename: Seung-Sang
authors.initials: SS
authors.lastname: Ko
authors.forename: Soon Won
authors.initials: SW
authors.lastname: Hong
authors.forename: Woo-Ick
authors.initials: WI
authors.lastname: Yang
authors.forename: Joo-Hang
authors.initials: JH
authors.lastname: Kim
authors.forename: Gwi Eon
authors.initials: GE
authors.lastname: Kim
authors.forename: Kyong Sik
authors.initials: KS
authors.lastname: Lee
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D018572:Disease-Free Survival; D047629:Estrogen Receptor beta; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017403:In Situ Hybridization; D008207:Lymphatic Metastasis; D011379:Prognosis; D012333:RNA, Messenger / Q000378:metabolism; D012334:RNA, Neoplasm / Q000378:metabolism; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D047629:Estrogen Receptor beta; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D011960:Receptors, Estrogen