[Therapy strategy in the treatment of patients with drug-resistant pulmonary tuberculosis].
The article contains a clinical- X-ray- and laboratory description of 56 patients with tuberculosis (disease length ranging from 2 to 5 years), who, during the previous treatment stage, received a therapy in compliance with the generally accepted methods and without any effect. All patients discharged bacteria. Drug-resistance to 3 and more preparations was registered in all patients. A complex approach to the therapy of patients with destructive pulmonary tuberculosis is suggested, within the study, with regard for the presence of multidrug-resistance of Mycobacterium tuberculosis (MBT), for a degree of inactivation of isoniazid and for a degree of bacterial-static activity of patient's blood, which provides for a higher treatment efficiency.
Ivanova
L A
LA
Pavlova
M V
MV
Archakova
L I
LI
D000904:Antibiotics, Antitubercular / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D007611:Aprotinin / Q000627:therapeutic use*; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D012293:Rifampin / Q000627:therapeutic use*; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D000904:Antibiotics, Antitubercular; D000998:Antiviral Agents; D007611:Aprotinin; D007538:Isoniazid; D012293:Rifampin