title: [A case of advanced gallbladder cancer with biliary tract stenosis which responded to TS-1 chemotherapy].
abstract: TS-1 is reported to be beneficial for advanced gastric cancer, but there is no report on its use for advanced gallbladder cancer. The present patient was a 64-year-old woman with advanced gallbladder cancer with severe biliary tract stenosis. The primary tumor was located in the neck of the gallbladder and peripancreatic lymph node metastasis was detected. TS-1 100 mg/day was administered orally for 21 days and CDDP 30 mg/day on days 1, 8 by drip infusion. Grade 4 neutropenia was observed in the first cycle, and TS-1 alone was used for further treatment. After 2 courses, primary tumor showed PR and lymph node metastasis had disappeared. Biliary stenosis was remarkably improved. We conclude that TS-1 might be beneficial in the treatment of advanced gallbladder cancer.
authors.affiliation: Dept. of Surgery, Tsukuba Gastroenterogical Hospital.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Kuramochi
authors.forename: Nobuo
authors.initials: N
authors.lastname: Tenma
authors.forename: Masaki
authors.initials: M
authors.lastname: Ohashi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001660:Biliary Tract Diseases / Q000150:complications*; D002945:Cisplatin / Q000008:administration & dosage; D003251:Constriction, Pathologic / Q000150:complications; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D005706:Gallbladder Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D011725:Pyridines / Q000008:administration & dosage; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin