Comparison of different risk factors that result in endothelial damage leading to diabetic microangiopathy.
In this study, the effect of different risk factors (hyperglycemia, hypertension, hyperlipidemia, hyperuricemia) on endothelial damage was evaluated in 61 (two of them were type 1; the other patients were type 2) diabetic patients. von Willebrand factor antigen was used as the marker of the endothelial damage. Although there was no significant decrease (P > 0.05) in von Willebrand factor level after regulation of nonregulated diabetes, a significant decrease was determined in nonregulated and hypertensive diabetic patients after improvement of risk factors (P < 0.05). As a result, nonregulated diabetes alone has less effect than nonregulated diabetes plus other risk factors (particularly hypertension) on diabetic angiopathy.
Kayacan
Seyit Mehmet
SM
Division of Nephrology, Department of Internal Medicine, Istanbul School of Medicine, Istanbul, Turkey. kayacansm@yahoo.com
Kazancioğlu
Rümeyza
R
Oflaz
Hüseyin
H
Tuna
Serafettin
S
D000328:Adult; D000941:Antigens / Q000097:blood*; D048909:Diabetes Complications; D003925:Diabetic Angiopathies / Q000209:etiology*; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D008875:Middle Aged; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood; D014841:von Willebrand Factor / Q000276:immunology
D000941:Antigens; C029417:Von Willebrand antigen; D014841:von Willebrand Factor; D014527:Uric Acid