[Human leucocyte antigen-DPA1 polymorphism distribution in Chengdu Chinese families with intrahepatic cholestasis of pregnancy].
OBJECTIVE
To investigate the relationship between human leucocyte antigen (HLA)-DPA1 region gene polymorphism and intrahepatic cholestasis of pregnancy (ICP).


METHODS
The HLA-DPA1 alleles of 25 ICP families and 25 normal control group families were analysed by polymerase chain reaction-sequence specific primers(PCR-SSP) method.


RESULTS
The analysis of the frequencies and feto-maternal or couples sharing of the DPA1 alleles showed that no statistically significant difference was observed between the two study groups.


CONCLUSIONS
It is unlikely that an HLA-DPA1 allele is primarily associated with susceptibility or resistance to ICP.
Zhang
Li
L
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Liu
Shuyun
S
Chen
Qiang
Q
Yang
Xuemei
X
Chen
Xianhui
X
D000483:Alleles; D002780:Cholestasis, Intrahepatic / Q000235:genetics*; D005260:Female; D006682:HLA-DP Antigens / Q000235:genetics*; D059867:HLA-DP alpha-Chains; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018807:Polymorphism, Single-Stranded Conformational; D011247:Pregnancy; D011248:Pregnancy Complications
D006682:HLA-DP Antigens; D059867:HLA-DP alpha-Chains; C071172:HLA-DPA1 antigen