Fatal sodium valproate-induced hypersensitivity syndrome with lichenoid dermatitis and fulminant hepatitis.
Anticonvulsant hypersensitivity syndrome caused by sodium valproate (Depakene) has rarely been reported. Here we describe a patient who presented with nonspecific polymorphous eruptions, fulminant hepatitis, and jaundice. Lichenoid dermatitis was found in the skin biopsy specimen. Toxic hepatitis and microvesicular steatosis were found in the liver biopsy specimen, consistent with valproate hepatotoxicity.
Huang
Yau-Li
YL
Department of Dermatology Chang Gung Memorial Hospital, Taipei, Taiwan.
Hong
Hong-Shang
HS
Wang
Zen-Whe
ZW
Kuo
Tseng-tong
TT
D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017512:Lichenoid Eruptions / Q000139:chemically induced*; D017093:Liver Failure / Q000139:chemically induced*; D009207:Myoclonus / Q000188:drug therapy; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
D000927:Anticonvulsants; D014635:Valproic Acid