Variant Creutzfeldt-Jakob disease.
A variant form of Creutzfeldt-Jakob disease (vCJD) has had major impact in Europe during the last decade. In this article, we review the aetiology of vCJD and its relation with bovine spongiform encephalopathy. Further, treatment of the disease, the strategies focusing on prevention of transmission, future prospects, and the limitations encountered in epidemiological research of vCJD are discussed.
Croes
Esther A
EA
Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands. e.croes@erasmusmc.nl
van Duijn
Cornelia M
CM
D000818:Animals; D002417:Cattle; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D016643:Encephalopathy, Bovine Spongiform / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D005060:Europe / Q000453:epidemiology; D006801:Humans