title: Evaluation of nucleotide derivatives and sugar nucleotide analogs as inhibitors of glycosyltransferases.
abstract: The inhibition of glycosyltransferases was studied using uridine monophosphate derivatives and uridine diphosphate sugar analogs. Modification in the nucleoside portion caused selective inhibition of glycosyltransferases.
authors.affiliation: Research Department, Noguchi Institute, 1-8-1, Kaga, Itabashi-ku, Tokyo 173-0003, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Osumi
authors.forename: N
authors.initials: N
authors.lastname: Kawauchi
authors.forename: A H
authors.initials: AH
authors.lastname: Lu
authors.forename: O
authors.initials: O
authors.lastname: Hindsgaul
authors.forename: M M
authors.initials: MM
authors.lastname: Palcic
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D016695:Glycosyltransferases / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D007700:Kinetics; D017351:N-Acetylglucosaminyltransferases / Q000037:antagonists & inhibitors; D009711:Nucleotides / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014530:Uridine Diphosphate / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D014542:Uridine Monophosphate / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D009711:Nucleotides; D014530:Uridine Diphosphate; D014542:Uridine Monophosphate; D016695:Glycosyltransferases; D017351:N-Acetylglucosaminyltransferases; C052254:alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase