Antioxidant status and lipid peroxidation in type II diabetes mellitus.
Diabetes Mellitus (DM), a state of chronic hyperglycaemia, is a common disease affecting over 124 million individuals worldwide. In this study, erythrocyte glutathione levels, lipid peroxidation, superoxide dismutase, catalase, and glutathione peroxidase and some extracellular antioxidant protein levels of patients with type II diabetes mellitus and healthy controls were investigated. Thirty-eight patients (21 males; with age of mean +/- SD, 53.1+/-9.7 years) and 18 clinically healthy subjects (10 males; with age of mean +/- SD, 49.3+/-15.2 years) were included in the study. Levels of erythrocyte lipid peroxidation, serum ceruloplasmin and glucose levels, HbA1C levels, and erythrocyte catalase activity were significantly increased, whereas serum albumin and transferrin levels, erythrocyte glutathione levels, and glutathione peroxidase activity were significantly decreased compared to those of controls. There was no significant difference in superoxide dismutase activity compared to controls. The results suggest that the antioxidant deficiency and excessive peroxide-mediated damage may appear in non-insulin dependent diabetes mellitus.
Memisoğullari
Ramazan
R
Department of Biochemistry, Medical School, Atatürk University, Erzurum, Turkey. rmemisogullari@hotmail.com
Taysi
Seyithan
S
Bakan
Ebubekir
E
Capoglu
Ilyas
I
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D002374:Catalase / Q000097:blood; D002570:Ceruloplasmin / Q000378:metabolism; D003627:Data Interpretation, Statistical; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000097:blood; D014168:Transferrin / Q000378:metabolism
D000975:Antioxidants; D001786:Blood Glucose; D002374:Catalase; D002570:Ceruloplasmin; D005978:Glutathione; D005979:Glutathione Peroxidase; D006442:Glycated Hemoglobin; D008315:Malondialdehyde; D012709:Serum Albumin; D013482:Superoxide Dismutase; D014168:Transferrin