title: Use of QSARs in international decision-making frameworks to predict health effects of chemical substances.
abstract: This article is a review of the use of quantitative (and qualitative) structure-activity relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute toxicity, mutagenicity, carcinogenicity, and other health effects. A number of SAR and QSAR applications, by regulatory agencies and authorities, are reviewed. These include the use of simple QSAR analyses, as well as the use of multivariate QSARs, and a number of different expert system approaches.
authors.affiliation: School of Pharmacy and Chemistry, Liverpool John Moores University, Liverpool, England. m.t.cronin@livjm.ac.uk
authors.forename: Mark T D
authors.initials: MT
authors.lastname: Cronin
authors.forename: Joanna S
authors.initials: JS
authors.lastname: Jaworska
authors.forename: John D
authors.initials: JD
authors.lastname: Walker
authors.forename: Michael H I
authors.initials: MH
authors.lastname: Comber
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Watts
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Worth
mesh_terms: D000818:Animals; D003659:Decision Making, Organizational; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D004785:Environmental Pollutants / Q000009:adverse effects*; D005062:European Union; D005103:Expert Systems; D033161:Government Regulation; D015386:Hazardous Substances / Q000009:adverse effects*; D007391:International Cooperation; D021281:Quantitative Structure-Activity Relationship; D018675:Toxicity Tests; D014481:United States
chemical_list: D004785:Environmental Pollutants; D015386:Hazardous Substances