Insulinomimetic zinc(II) complexes with natural products: in vitro evaluation and blood glucose lowering effect in KK-Ay mice with type 2 diabetes mellitus.
In vitro insulinomimetic activities of Zn(II) complexes with three natural products, betaine, L-lactic acid, and D-(-)-quinic acid (qui), were found in rat adipocytes treated with epinephrine in terms of the inhibition of free fatty acid release. Based on the results, the blood glucose lowering effect in KK-A(y) mice with type 2 diabetes mellitus was observed by daily i.p. injections of a monomeric zinc(II) complex, Zn(qui)(2), for 13 d.
Kojima
Yoshitane
Y
Department of Chemistry, Graduate School of Science, Osaka City University, Osaka, Japan. kojima@sci.osaka-cu.ac.jp
Yoshikawa
Yutaka
Y
Ueda
Eriko
E
Ueda
Rie
R
Yamamoto
Shuhei
S
Kumekawa
Katsumi
K
Yanagihara
Naohisa
N
Sakurai
Hiromu
H
D000818:Animals; D001688:Biological Products / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007328:Insulin / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D051381:Rats; D017967:Zinc Compounds / Q000494:pharmacology* / Q000627:therapeutic use
D001688:Biological Products; D001786:Blood Glucose; D007328:Insulin; D017967:Zinc Compounds