Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.
Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative beta-proteobacteria that colonize the respiratory tracts of mammals. B. pertussis is a strict human pathogen of recent evolutionary origin and is the primary etiologic agent of whooping cough. B. parapertussis can also cause whooping cough, and B. bronchiseptica causes chronic respiratory infections in a wide range of animals. We sequenced the genomes of B. bronchiseptica RB50 (5,338,400 bp; 5,007 predicted genes), B. parapertussis 12822 (4,773,551 bp; 4,404 genes) and B. pertussis Tohama I (4,086,186 bp; 3,816 genes). Our analysis indicates that B. parapertussis and B. pertussis are independent derivatives of B. bronchiseptica-like ancestors. During the evolution of these two host-restricted species there was large-scale gene loss and inactivation; host adaptation seems to be a consequence of loss, not gain, of function, and differences in virulence may be related to loss of regulatory or control functions.
Parkhill
Julian
J
The Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. parkhill@sanger.ac.uk
Sebaihia
Mohammed
M
Preston
Andrew
A
Murphy
Lee D
LD
Thomson
Nicholas
N
Harris
David E
DE
Holden
Matthew T G
MT
Churcher
Carol M
CM
Bentley
Stephen D
SD
Mungall
Karen L
KL
Cerdeño-Tárraga
Ana M
AM
Temple
Louise
L
James
Keith
K
Harris
Barbara
B
Quail
Michael A
MA
Achtman
Mark
M
Atkin
Rebecca
R
Baker
Steven
S
Basham
David
D
Bason
Nathalie
N
Cherevach
Inna
I
Chillingworth
Tracey
T
Collins
Matthew
M
Cronin
Anne
A
Davis
Paul
P
Doggett
Jonathan
J
Feltwell
Theresa
T
Goble
Arlette
A
Hamlin
Nancy
N
Hauser
Heidi
H
Holroyd
Simon
S
Jagels
Kay
K
Leather
Sampsa
S
Moule
Sharon
S
Norberczak
Halina
H
O'Neil
Susan
S
Ormond
Doug
D
Price
Claire
C
Rabbinowitsch
Ester
E
Rutter
Simon
S
Sanders
Mandy
M
Saunders
David
D
Seeger
Katherine
K
Sharp
Sarah
S
Simmonds
Mark
M
Skelton
Jason
J
Squares
Robert
R
Squares
Steven
S
Stevens
Kim
K
Unwin
Louise
L
Whitehead
Sally
S
Barrell
Bart G
BG
Maskell
Duncan J
DJ
D001483:Base Sequence; D001884:Bordetella / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D016950:Bordetella bronchiseptica / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D001886:Bordetella pertussis / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D004269:DNA, Bacterial; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D013045:Species Specificity
D004269:DNA, Bacterial