title: Comparative performances of selected chiral HPLC, SFC, and CE systems with a chemically diverse sample set.
abstract: Pharmaceutical companies have a continuous need to resolve new racemates. Analysis may be required in aqueous and nonaqueous media, or in the presence of several different sets of potentially interfering compounds. There is often a preparative requirement. For these reasons analysts may require a number of different separation systems capable of resolving a given pair of enantiomers. We wished to improve upon existing approaches that address this situation and undertook a program of work to screen over 100 racemates, selected for their chemical diversity, on over 100 different chiral HPLC, SFC, and CE systems. Here we report results of this comparison and illustrate the use of rapid gradient screening as a valuable tool for chiral method development.
authors.affiliation: Strategic Technologies, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.
authors.forename: Phil
authors.initials: P
authors.lastname: Borman
authors.forename: Bob
authors.initials: B
authors.lastname: Boughtflower
authors.forename: Kaye
authors.initials: K
authors.lastname: Cattanach
authors.forename: Kathy
authors.initials: K
authors.lastname: Crane
authors.forename: Keith
authors.initials: K
authors.lastname: Freebairn
authors.forename: Greg
authors.initials: G
authors.lastname: Jonas
authors.forename: Ian
authors.initials: I
authors.lastname: Mutton
authors.forename: Asha
authors.initials: A
authors.lastname: Patel
authors.forename: Matt
authors.initials: M
authors.lastname: Sanders
authors.forename: Duncan
authors.initials: D
authors.lastname: Thompson