[The study of biological properties of gliomas].
In order to explore the new methods of biological treatment of human gliomas, this project is to study the biological properties of gliomas from four different aspects, the results show that there is a IL-6 autocrine loop in human gliomas and the growth of gliomas will be inhibited when the autocrine loop is broken. There is a magnificent predominant expression of Th2 cytokines in human gliomas and human glioma cells, the switching of Th2 to Th1 can inhibit the proliferation of glioma cells. The dosage of 100 micrograms/ml of erythromycin is the best of therapeutic effect. Angiostatin can not only inhibit the vascular endothelial growth, but also have the inhibitory role on the growth of glioma cells in vivo. The above studies have provided some new ideas and will be very helpful for the treatment of glioma patients.
Li
Gang
G
Department of Neurosurgery, No. 2 Hospital of Shandong University, Jinan 250033, China.
Zhang
Qing-lin
QL
Wang
Jie-zhen
JZ
Liu
Fu-sheng
FS
Hu
Yong-sheng
YS
Wang
Cheng-wei
CW
Li
Xin-gang
XG
Pang
Qi
Q
D043168:Angiostatins / Q000494:pharmacology; D000818:Animals; D001691:Biological Therapy; D001932:Brain Neoplasms / Q000378:metabolism* / Q000628:therapy; D019008:Drug Resistance, Neoplasm; D005910:Glioma / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000378:metabolism
D015850:Interleukin-6; D012333:RNA, Messenger; D043168:Angiostatins