title: Comparison of different risk factors that result in endothelial damage leading to diabetic microangiopathy.
abstract: In this study, the effect of different risk factors (hyperglycemia, hypertension, hyperlipidemia, hyperuricemia) on endothelial damage was evaluated in 61 (two of them were type 1; the other patients were type 2) diabetic patients. von Willebrand factor antigen was used as the marker of the endothelial damage. Although there was no significant decrease (P > 0.05) in von Willebrand factor level after regulation of nonregulated diabetes, a significant decrease was determined in nonregulated and hypertensive diabetic patients after improvement of risk factors (P < 0.05). As a result, nonregulated diabetes alone has less effect than nonregulated diabetes plus other risk factors (particularly hypertension) on diabetic angiopathy.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Istanbul School of Medicine, Istanbul, Turkey. kayacansm@yahoo.com
authors.forename: Seyit Mehmet
authors.initials: SM
authors.lastname: Kayacan
authors.forename: Rümeyza
authors.initials: R
authors.lastname: Kazancioğlu
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Oflaz
authors.forename: Serafettin
authors.initials: S
authors.lastname: Tuna
mesh_terms: D000328:Adult; D000941:Antigens / Q000097:blood*; D048909:Diabetes Complications; D003925:Diabetic Angiopathies / Q000209:etiology*; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D008875:Middle Aged; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood; D014841:von Willebrand Factor / Q000276:immunology
chemical_list: D000941:Antigens; C029417:Von Willebrand antigen; D014841:von Willebrand Factor; D014527:Uric Acid