Mediastinal T-cell lymphoma in a boy 7 years after treatment of supratentorial primitive neuroectodermal tumor.
Medulloblastoma/primitive neuroectodermal tumor (PNET) is one of the most common central nervous system tumors in children and requires aggressive multimodality therapy. The authors describe a patient who developed mediastinal T-cell lymphoma 7 years after treatment of supratentorial PNET. Despite a good tumor response, the patient died during induction therapy because of invasive pulmonary aspergillosis. The authors conclude from this case that patients treated for medulloblastoma/PNET should be followed carefully for years. In addition, patients with second malignancies should be considered as a high-risk population for opportunistic infections.
Lehrnbecher
Thomas
T
Department of Pediatric Hematology and Oncology, Children's Hospital III, Frankfurt, Germany. thomas_lehrnbecher@yahoo.com
Deinlein
Frank
F
Marx
Alexander
A
Kühl
Joachim
J
D001229:Aspergillosis, Allergic Bronchopulmonary / Q000473:pathology; D001932:Brain Neoplasms / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D017809:Fatal Outcome; D006801:Humans; D016399:Lymphoma, T-Cell / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D008527:Medulloblastoma / Q000628:therapy*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D018242:Neuroectodermal Tumors, Primitive / Q000628:therapy*; D012307:Risk Factors