Synthesis of 1,2,3-triazolo-carbanucleoside analogues of ribavirin targeting an HCV in replicon.
The synthesis of carbocyclic and phosphonocarbocyclic analogues of ribavirin, an anti-HCV inhibitor, are described. Those compounds were evaluated against HCV but also against other important viruses in order to determine their spectrum of antiviral activity. Compounds 6 and 13 displayed a moderate IC(50) against HIV-1 of 43.8 and 37 microM, respectively.
Saito
Yoshio
Y
Institut de Chimie Organique et Analytique, ICOA UMR 6005, UFR Sciences, BP 6759, 45067 Cedex 2, Orléans, France.
Escuret
Vanessa
V
Durantel
David
D
Zoulim
Fabien
F
Schinazi
Raymond F
RF
Agrofoglio
Luigi A
LA
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016174:Hepacivirus / Q000737:chemistry / Q000187:drug effects* / Q000235:genetics; D009705:Nucleosides / Q000138:chemical synthesis; D012093:Replicon; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000998:Antiviral Agents; D009705:Nucleosides; D012254:Ribavirin