title: Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins.
abstract: SNARE proteins function at the center of membrane fusion reactions by forming complexes with each other via their coiled-coil domains. Several SNAREs have N-terminal domains (NTDs) that precede the coiled-coil domain and have critical functions in regulating the fusion cascade. This review will highlight recent findings on NTDs of syntaxins, the longin domain of VAMP proteins and SNAP-23/25 homologues in yeast. Biochemical and genetic experiments as well as the resolution of several NMR and crystal structures of SNARE NTDs shed light on their diverse function.
authors.affiliation: Biochemie Zentrum Heidelberg (BZH), University of Heidelberg, Im Neuenheimer Feld 328, 69120, Heidelberg, Germany. cu2@ix.urz.uni-heidelberg.de
authors.forename: Lars E P
authors.initials: LE
authors.lastname: Dietrich
authors.forename: Christine
authors.initials: C
authors.lastname: Boeddinghaus
authors.forename: Tracy J
authors.initials: TJ
authors.lastname: LaGrassa
authors.forename: Christian
authors.initials: C
authors.lastname: Ungermann
mesh_terms: D000818:Animals; D006801:Humans; D008561:Membrane Fusion / Q000502:physiology*; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology*; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D050600:SNARE Proteins; D013329:Structure-Activity Relationship; D033921:Vesicular Transport Proteins
chemical_list: D008565:Membrane Proteins; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins