title: Variable-ionic strength kinetic experiments in drug stability studies.
abstract: The dependence of the pseudo-first-order rate constant on the ionic strength for the alkaline hydrolysis of indomethacin has been obtained, for the first time, in a single kinetic experiment carried out by varying with time the salt concentration inside the reaction vessel. The kinetic profile obtained was processed using as a mathematical model the variable-parameter kinetic equation containing the Bronsted-Bjerrum equation as the dependence function. The results are in good agreement with those obtained by the traditional method but the experimental time is reduced to about one-tenth.
authors.affiliation: Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica, Università di Messina, Salita Sperone 31, Vill S Agata, 98166 Messina, Italy. alibrandi@chem.unime.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Alibrandi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Coppolino
authors.forename: Santi
authors.initials: S
authors.lastname: D'Aliberti
authors.forename: Paola
authors.initials: P
authors.lastname: Ficarra
authors.forename: Norberto
authors.initials: N
authors.lastname: Micali
authors.forename: Antonino
authors.initials: A
authors.lastname: Villari
mesh_terms: D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007213:Indomethacin / Q000493:pharmacokinetics*; D008956:Models, Chemical; D009994:Osmolar Concentration
chemical_list: D007213:Indomethacin