Autologous recovery with protractedly undetectable donor chimerisms can precede stable donor engraftment in a nonmyeloablative cord blood transplant.
Low levels of donor chimerism on day 28 after hematopoietic stem cell transplantation are highly predictive of a subsequent rejection of donor cells A recent report on nonmyeloablative transplants has demonstrated that patients who engrafted after transplantation had at least 10% donor cells detectable at this time point. A patient is described who received a nonmyeloablative umbilical cord blood transplant and experienced subsequent full engraftment of donor cells despite the absence of donor chimerism at 4 weeks posttransplantation.
Khee
William Hwang Ying
WH
Department of Haematology, Singapore General Hospital, Singapore, Republic of Singapore. ghehyk@sgh.com.sg
Chye
Patrick Tan Huat
PT
Hoe
Tan Cheng
TC
Fung
How Gee
HG
Khiang
Heng Khee
HK
Tee
Goh Yeow
GY
D000328:Adult; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D006085:Graft Survival; D006801:Humans; D008297:Male; D013997:Time Factors; D018183:Transplantation Chimera; D019172:Transplantation Conditioning / Q000379:methods; D014182:Transplantation, Autologous