[Functional evaluation for neural progenitor cells transplantation to treat spinal cord injury in rats].
OBJECTIVE
To evaluate the functional recovery of acute spinal cord-injured rats treated by immortalized neural progenitor cells transplantation.


METHODS
Spinal cord injury (SCI) model was built by revised Allen method. Immortalized neural progenitor cells (G3 line) transplantation was performed on day 9 after injury. Culture medium and nontreatment groups were used as control. BBB scores were checked every week to show the motor function recovery and Motor Evoked Potentials (MEPs) were recorded 8 and 12 weeks after transplantation to display the conduction of injured spinal cord.


RESULTS
There were not significantly differences for BBB scores among the three groups within 12 weeks after grafting; but MEPs were significantly enhanced in G3 group compared with control and sham groups.


CONCLUSIONS
Immortalized neural progenitor cells transplantation can significantly improve the conduction of spinal cord injured rats.
Xu
Guanghui
G
Department of Orthopedics, Peking University Third Hospital, Beijing 100083, China.
Li
Xiaoxia
X
Bai
Jinzhu
J
Cai
Qinlin
Q
Li
Lingsong
L
Shen
Li
L
D000818:Animals; D019054:Evoked Potentials, Motor; D005260:Female; D009474:Neurons / Q000637:transplantation*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000628:therapy*; D033581:Stem Cell Transplantation