Neuroprotective effect of ACTH (4-9) in degeneration of hippocampal nerve cells caused by dexamethasone: morphological studies.
The purpose of this research was an assessment of neuroprotective effect of ACTH (4-9) in degenerative changes of nerve cells induced by dexamethasone. Experiments were led on Albino-Swiss mouse males. We examine morphological changes of neurons in the dorsal hippocampus in slides stained with cresyl violet and we performed quantitative analysis of neurodegenerative changes using a computer analyser of histological pictures. Achieved results indicate that ACTH (4-9) shows neuroprotective effect against neurotoxic influence of dexamethasone. This chemical inhibits dexamethasone induced degeneration of hippocampal nerve cells having morphological features characteristic of apoptosis.
Sekita-Krzak
Joanna
J
Department of Histology and Embryology with the Lab of Experimental Cytology, Department of Clinical Pharmacology, Medical University of Lublin.
Czerny
Krystyna
K
Zebrowska-Łupina
Iwona
I
Stepniewska
Maria
M
Visconti
Józef
J
Koziej
Jacek
J
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects*; D002452:Cell Count; D003907:Dexamethasone / Q000008:administration & dosage* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009410:Nerve Degeneration / Q000139:chemically induced / Q000473:pathology*; D018696:Neuroprotective Agents / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000187:drug effects* / Q000473:pathology*; D012016:Reference Values
D018696:Neuroprotective Agents; D010446:Peptide Fragments; C028024:ACTH (4-9); D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone