title: Assessing clinical and functional outcomes in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial.
abstract: Schizophrenia is a symptomatically heterogeneous disorder characterized by the presence of positive and negative symptoms, and variable impairment in community functioning. Given the diversity of symptom presentations and functioning associated with schizophrenia, one of the key challenges facing the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial was the selection of efficient assessment measures appropriate to a community-based effectiveness trial. This article describes the rationale for the measurement approach adopted for the trial, provides a brief overview of the selected measures, and describes the process of training assessment raters for a large and geographically dispersed study group.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3173, Durham, NC 27710, USA. marvin.swartz@duke.edu
authors.forename: Marvin S
authors.initials: MS
authors.lastname: Swartz
authors.forename: Diana O
authors.initials: DO
authors.lastname: Perkins
authors.forename: T Scott
authors.initials: TS
authors.lastname: Stroup
authors.forename: Joseph P
authors.initials: JP
authors.lastname: McEvoy
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Nieri
authors.forename: David C
authors.initials: DC
authors.lastname: Haak
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001294:Attitude to Health; D002986:Clinical Trials as Topic; D003863:Depression / Q000175:diagnosis; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D008019:Life Style; D010043:Outcome and Process Assessment, Health Care; D011595:Psychomotor Agitation / Q000175:diagnosis; D011788:Quality of Life; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D019966:Substance-Related Disorders / Q000175:diagnosis; D011795:Surveys and Questionnaires
chemical_list: D014150:Antipsychotic Agents