[Human hepatitis B virus infection of tree shrews and Macaca assamensis in vivo].
OBJECTIVE
To examine sensitivity of the tree shrews and Macaca assamensis to human hepatitis B virus (HHBV) by serologic methods.


METHODS
Totally 233 tree shrews and 28 Macaca assamensis were inoculated with human sera containing HBV. After inoculation, the sera were collected weekly from them and HBV markers were detected with HBV ditecting ELISA kits.


RESULTS
Ninety percent of the tree shrews developed acute infection, among them, 44.4 % persisted for over one year, 33.3% of them developed chronic infection persisted for 2 years and one month; the persistence of HBV in Macaca assamensis was much shorter.


CONCLUSIONS
These data clearly indicated that tree shrew may be used as an animal model for study of chronic HBV infection, whereas, Macaca assamensis, showed only a transient sensitivity to HHBV.
Wang
Shu-sheng
SS
Guangxi Anti-Epidemic and Health Center, Nanning, China.
Su
Jian-jia
JJ
Zhang
Hua-yuan
HY
Li
Yuan
Y
Zhang
Tao
T
Wang
You-chun
YC
Huang
Guo-yong
GY
Qin
Liu-liang
LL
Ge
Xian-min
XM
Yu
Yang
Y
Li
He-min
HM
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000276:immunology / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000302:isolation & purification; D006801:Humans; D008251:Macaca; D008297:Male; D014418:Tupaiidae
D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens