title: [Experience with vaccine prophylaxis of hepatitis B among different groups of children].
abstract: The immunological activity of different vaccines against hepatitis B was evaluated in the Hepatological Center organized on the basis of the Infectious Hospital in Tula. Newborn infants were immunized with the use of the following vaccines: Engerix B (Belgium), Combiotech (Russia), Euvax B (Aventis Pastèur, South Korea). Altogether, after the full course of immunization anti-HBs were detected in 76 children out of 81 (in 93.8%). Vaccine Engerix B, when introduced according to the schedule 0-1-2-12 months, exhibited high immunogenic properties in a group of infants born of women with persistent HBs-antigenemia. Anti-HBs at a concentration exceeding 1000 I.U./I could be detected in 84.6%. In another group of children immunized according to the schedule 0-1-6 months first with vaccine Combiotech at the age of 0 and 1 month, then (at the age of 6 months) with vaccine Euvax, the presence of postvaccinal anti HBs at protective concentration was registered in all children. After immunization against hepatitis B with the use of all above-mentioned vaccines introduced according to both schedules high immunological activity and safety of immunization were noted.
authors.affiliation: Hepatological Center of Infectious Hospital No. 2, Tula, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Moskovskaia
authors.forename: L E
authors.initials: LE
authors.lastname: Kuzina
authors.forename: T V
authors.initials: TV
authors.lastname: Anichkina
authors.forename: I K
authors.initials: IK
authors.lastname: Aleshin
authors.forename: L A
authors.initials: LA
authors.lastname: Ul'ianova
authors.forename: S N
authors.initials: SN
authors.lastname: Kuzin
mesh_terms: D002353:Carrier State / Q000276:immunology; D004341:Drug Evaluation; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D012426:Russia; D013997:Time Factors; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic