title: Design and synthesis of paromomycin-related heterocycle-substituted aminoglycoside mimetics based on a mass spectrometry RNA-binding assay.
authors.affiliation: Ribapharm, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA. yding@icnpharm.com
authors.forename: Yili
authors.initials: Y
authors.lastname: Ding
authors.forename: Steven A
authors.initials: SA
authors.lastname: Hofstadler
authors.forename: Eric E
authors.initials: EE
authors.lastname: Swayze
authors.forename: Lisa
authors.initials: L
authors.lastname: Risen
authors.forename: Richard H
authors.initials: RH
authors.lastname: Griffey
mesh_terms: D000617:Aminoglycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D001667:Binding, Competitive; D002240:Carbohydrate Sequence; D015195:Drug Design; D008024:Ligands; D008956:Models, Chemical; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010303:Paromomycin / Q000737:chemistry*; D012336:RNA, Ribosomal, 16S / Q000737:chemistry* / Q000378:metabolism; D012337:RNA, Ribosomal, 18S / Q000737:chemistry* / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D000617:Aminoglycosides; D008024:Ligands; D012336:RNA, Ribosomal, 16S; D012337:RNA, Ribosomal, 18S; D010303:Paromomycin