No alteration in platelet function or coagulation induced by EGb761 in a controlled study.
Some cases of spontaneous bleeding have been reported in patients treated with Ginkgo biloba. A prospective, double-blind, randomized, placebo-controlled study was carried out in 32 young male healthy volunteers to evaluate the effect of three doses of Ginkgo biloba extract (120, 240 and 480 mg/day for 14 days) on hemostasis, coagulation and fibrinolysis. This study did not reveal any alteration of platelet function or coagulation. This suggests that the reported clinical bleeding events in patients receiving Ginkgo biloba extract are not related to pharmacological properties of EGb761.
Bal Dit Sollier
C
C
Experimental Thrombosis and Atherosclerosis Laboratory, IVS, Lariboisière Hospital, Paris, France.
Caplain
H
H
Drouet
L
L
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005342:Fibrinolysis / Q000187:drug effects; D020441:Ginkgo biloba / Q000009:adverse effects / Q000737:chemistry*; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011446:Prospective Studies; D013917:Thrombin / Q000096:biosynthesis / Q000235:genetics; D010959:Tissue Plasminogen Activator / Q000032:analysis; D000096983:Ginkgo Extract
D000244:Adenosine Diphosphate; D010936:Plant Extracts; D013917:Thrombin; D010959:Tissue Plasminogen Activator; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract