title: [New targets for drug therapeutics: receptors for purines and pyrimidines].
abstract: Endogenous nucleoside and nucleotide mediate a lot of functions via cell surface P receptors (receptors for purines and pyrimidines) in many organs. Nucleoside and nucleotide have protective roles in the events such as cancer, apoptosis, ischemia, wound healing, osteoporosis, drug toxicity, inflammation and pain. Moreover, the development of selective agonists and antagonists for P1, P2 receptors and P receptor subtypes may provide novel drugs in therapeutic strategies.
authors.affiliation: Hebei Medical University School of Pharmacy.
authors.forename: Lei-Ming
authors.initials: LM
authors.lastname: Ren
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.forename: Shu-Kun
authors.initials: SK
authors.lastname: Yao
authors.forename: Zhong-Ning
authors.initials: ZN
authors.lastname: Zhu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D015195:Drug Design; D006801:Humans; D011687:Purines / Q000378:metabolism; D011743:Pyrimidines / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology*; D011983:Receptors, Purinergic / Q000187:drug effects / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology
chemical_list: D011687:Purines; D011743:Pyrimidines; D011956:Receptors, Cell Surface; D011983:Receptors, Purinergic