title: [Binucleated lymphocyte lymphocytosis].
abstract: We reported here a case of persistent polyclonal B-cell lymphocytosis (PPBL) in a 31-year-old female patient. Peripheral blood smears showed atypical binucleated lymphocytes which were polyclonal B-cells with kappa and lambda expression, and without clonal rearrangement of immunoglobulin heavy chain. Cytogenetic analysis found a trisomy 8, with premature chromosome condensation. Clinically, PPBL is associated with moderated splenomegaly, adenopathy, and smoking. It remains to be established whether PPBL is a real pathology or a simple cytological abnormality.
authors.affiliation: Laboratoire d'hématologie, Centre hospitalier, 77100 Meaux. a-vincenot@ch-meaux.fr
authors.forename: A
authors.initials: A
authors.lastname: Vincenot-Blouin
authors.forename: O
authors.initials: O
authors.lastname: Timbely
authors.forename: W
authors.initials: W
authors.lastname: Abarah-Atassi
authors.forename: H
authors.initials: H
authors.lastname: Mossafa
authors.forename: C
authors.initials: C
authors.lastname: Allard
authors.forename: F
authors.initials: F
authors.lastname: Michel
authors.forename: E
authors.initials: E
authors.lastname: André-Kerneïs
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000473:pathology; D002467:Cell Nucleus; D005260:Female; D006801:Humans; D008218:Lymphocytosis / Q000473:pathology*