[Intra-arterial thrombolysis in patients with acute ischemic stroke of the cervical internal carotid artery occlusive disease].
OBJECTIVE
To observe the safety and efficacy of local intra-arterial thrombolysis (LIT) in patients with acute ischemic stroke of cervical internal carotid artery occlusive disease.


METHODS
10 patients were treated by LIT. 2 of 10 patients were further treated by either angioplasty or endarterectomy. Primary neuroradiological assessment was performed with CT in all patients. Angiographic recanalization level was classified according to thrombolysis in myocardial infarction (TIMI) grades. Clinical outcome was classified as good for Modified Rankin Scale (MRS) scores of 0 to 3 and as poor for MRS scores of 4 to 6.


RESULTS
Complete/partial recanalization after infusion was accomplished in 8 patients, seven of whom had good clinical outcome. Cerebral hemorrhage occurred in 2 of 10 patients.


CONCLUSIONS
The results of this study suggest that LIT may be helpful to improve the outcome in patients with acute cervical internal carotid artery occlusive disease if it is performed within 6 hours of stroke onset.
Zhang
Qing
Q
Department of Radiology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China. qingzhangs@yahoo.com.cn
Jin
Zheng-yu
ZY
Huang
Yi-ning
YN
Xu
Wei-hai
WH
Ren
Zu-yuan
ZY
Su
Chang-bao
CB
Wang
Ren-zhi
RZ
Liu
Wei
W
Pan
Jie
J
Cui
Li-ying
LY
Gao
Shan
S
Ye
Jian
J
Dai
Jian-ping
JP
D000293:Adolescent; D000328:Adult; D000368:Aged; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000188:drug therapy* / Q000209:etiology; D015912:Thrombolytic Therapy / Q000379:methods; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
D014568:Urokinase-Type Plasminogen Activator