[Aneurysmal model induced by elastase].
OBJECTIVE
To induce the aneurysms by corrosion of aneurysmal wall with elastase, imitating clinical intracranial aneurysms patho-morhologically.


METHODS
The elastase-corroded arterial segments were transplanted onto lateral walls of carotid arteries. Follow-up and pathological examination of the aneurysms were made at two weeks and one month after construction.


RESULTS
The aneurysms formed by the transplantation of elastase-corroded arterial segments were found persistent or enlarge a little within one month. The aneurysms were purplish red and easy to rupture when exposed. The walls were deprived of elastic layer, and constructed by thin connective tissue.


CONCLUSIONS
The aneurysms made by transplanting elastase-corroded arterial segments are simple to built, while morphological and pathological characteristics are demonstrated good clinical mimicry, we believe our aneurysm model may well substitute the most popularly used aneurysms made of venous pouches.
Yin
K
K
Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, CAMS, Beijing 100050, China.
Ding
Y L
YL
Wu
Z X
ZX
Yang
X J
XJ
D000783:Aneurysm / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D002340:Carotid Artery Diseases / Q000139:chemically induced* / Q000473:pathology; D004195:Disease Models, Animal; D010196:Pancreatic Elastase; D011817:Rabbits
D010196:Pancreatic Elastase