title: Observations at the interface of mutation research and regulatory policy.
abstract: Between 1970 and 1975 developments in environmental mutagenesis proceeded with amazing speed. These developments were both structural and conceptual in nature. A new infrastructure was built and new concepts about how best to protect consumers from exposures to mutagens emerged. The internal dynamics within the Food and Drug Administration played an important role and is discussed with regard to modifications in testing protocols as well as changes in the overall approach used to protect consumers. It is clear that this exciting period in the early days of environmental mutagenesis has provided a base for growth and development of the field and continues to affect and guide future developments.
authors.affiliation: 4401 Sunset Drive, 32963, Vero Beach, FL , USA. wgflamm@attglobal.net
authors.forename: W Gary
authors.initials: WG
authors.lastname: Flamm
mesh_terms: D000818:Animals; D002274:Carcinogens, Environmental / Q000592:standards; D005502:Food / Q000592:standards; D033161:Government Regulation / Q000266:history*; D006291:Health Policy / Q000266:history*; D049673:History, 20th Century; D006801:Humans; D007880:Legislation, Drug / Q000266:history; D007881:Legislation, Food / Q000266:history; D009152:Mutagenicity Tests / Q000266:history* / Q000379:methods; D014116:Toxicology / Q000266:history / Q000379:methods; D014481:United States; D014486:United States Food and Drug Administration / Q000266:history*
chemical_list: D002274:Carcinogens, Environmental