Multiple pulmonary nodules in a patient with Crohn's disease.
Crohn's disease (CD) can be associated with respiratory involvement. Multiple pulmonary nodules are an infrequent finding in patients with CD. When they are found, histology usually shows sterile necrobiotic nodules, which are spherical aggregates of neutrophils, which frequently cavitate. We report a patient with inactive CD treated with mesalazine, who presented with multiple pulmonary nodules. Transthoracic biopsy of one of the nodules disclosed a benign, nongranulomatous inflammatory lymphoid infiltration. The radiographic abnormalities responded well to oral prednisone. Focal, nongranulomatous lymphoid infiltration thus must be considered in the differential diagnosis of multiple pulmonary nodules in patients with CD.
Golpe
Rafael
R
Respiratory, Pathology and Gastroenterology Sections and Radiology Service, Monforte De Lemos Hospital, Lugo, Spain. rafa898@separ.es
Mateos
Alfonso
A
Pérez-Valcárcel
Javier
J
Lapeña
José A
JA
García-Figueiras
Roberto
R
Blanco
Joaquín
J
D000368:Aged; D003424:Crohn Disease / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000150:complications*; D008214:Lymphocytes / Q000473:pathology