[The research development of single nucleotide polymorphism].
Single nucleotide polymorphism(SNP) is a novel set of polymorphism based on the single nucleotide variations at the genomic level, which distributes widely across the human genome and has high polymorphism information content (PIC). Now, tens of thousands SNPs have been discovered among the human genome and are introduced by many biological medicine networks. With the development of identification and analysis technique for SNP, especially the combination with DNA chips, they, as the third generation of genetic markers, are gradually fitable for fine-scale mapping of diseases, especially the complex diseases susceptibility genes and will eventually substitute for the most commonly used microsatellite markers presently.
Du
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National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS, PUMC, Beijing 100005, China.
Sun
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H
Fang
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F
D005819:Genetic Markers; D006801:Humans; D009693:Nucleic Acid Hybridization / Q000379:methods; D020641:Polymorphism, Single Nucleotide; D017421:Sequence Analysis / Q000379:methods
D005819:Genetic Markers