IL-13 and adenosine: partners in a molecular dance?
Inflammation and airway remodeling are two responses readily apparent in asthma and other inflammatory disorders of the airway and lungs. Both adenosine and IL-13 play critical roles in contributing pathways. A new study reveals a previously unrecognized interaction between adenosine and IL-13 that indicates a mutual stimulation that may contribute to the nature and severity of airway inflammation and fibrosis.
Grünig
Gabriele
G
Department of Pathology, St Luke's Roosevelt Hospital, New York, New York 10019, USA. gg398@columbia.edu
D000241:Adenosine / Q000502:physiology*; D000818:Animals; D001249:Asthma / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology; D018793:Interleukin-13 / Q000502:physiology*; D055370:Lung Injury; D051379:Mice; D008954:Models, Biological; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000502:physiology
D018793:Interleukin-13; D000241:Adenosine