title: A prospective clinical study of Mineral Trioxide Aggregate and IRM when used as root-end filling materials in endodontic surgery.
abstract: OBJECTIVE
  To assess the success rate of the root-end filling material, Mineral Trioxide Aggregate (MTA).
  
  
  METHODS
  Referred adult patients were recruited using strict entry criteria and randomly allocated to receive MTA or IRM. A standardized surgical technique was employed: the root end was resected perpendicularly and a root-end cavity was prepared ultrasonically and filled. A radiograph taken immediately after surgery was compared with those taken at 12 and 24 months. Customised film holders and the paralleling technique were used; radiographs were assessed by two trained observers using agreed criteria. The results from 122 patients (58 in IRM group, 64 in MTA group) after 12 months and 108 patients (47 in IRM group, 61 in MTA group) for the 24-month review period were analysed using the chi2 test.
  
  
  RESULTS
  The highest number of teeth with complete healing at both times was observed when MTA was used. When the numbers of teeth with complete and incomplete (scar) healing, and those with uncertain and unsatisfactory healing were combined, the success rate for MTA was higher (84% after 12 months, 92% after 24 months) compared with IRM (76% after 12 months, 87% after 24 months). However, statistical analysis showed no significant difference in success between materials (P > 0.05) at both 12 and 24 months.
  
  
  CONCLUSIONS
  In this study, the use of MTA as a root-end filling material resulted in a high success rate that was not significantly better than that obtained using IRM.
authors.affiliation: Department of Conservative Dentistry, GKT Dental Institute, King's College London, Guy's Hospital, London, UK. bunsan.chong@kcl.ac.uk
authors.forename: B S
authors.initials: BS
authors.lastname: Chong
authors.forename: T R
authors.initials: TR
authors.lastname: Pitt Ford
authors.forename: M B
authors.initials: MB
authors.lastname: Hudson
mesh_terms: D000328:Adult; D017607:Aluminum Compounds; D001047:Apicoectomy; D017610:Calcium Compounds; D019232:Dental Restoration Failure; D004338:Drug Combinations; D006801:Humans; D008768:Methylmethacrylates; D015588:Observer Variation; D010087:Oxides; D011446:Prospective Studies; D012184:Retrograde Obturation / Q000379:methods*; D012387:Root Canal Filling Materials; D017640:Silicates; D015035:Zinc Oxide-Eugenol Cement
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D008768:Methylmethacrylates; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; D015035:Zinc Oxide-Eugenol Cement; C086631:mineral trioxide aggregate; C031667:IRM cement