The synthesis of pyrrole(Py)/imidazole(Im) polyamide CPI conjugates which possess DNA interstrand cross-linking activity.
Covalent dimers of ImPyLDu86 with various linkers were synthesized and their DNA interstrand cross-linking abilities were examined. Denaturing polyacrylamide gel electrophoresis indicated that dimer molecule with tetramethylene linker efficiently produced interstrand cross-link only in the presence of appropriate partner PyIm triamides.
Bando
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Division of Biofunctional Molecules, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda, Tokyo 101-0062, Japan.
Iida
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Saito
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Sugiyama
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D001483:Base Sequence; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D019281:Dimerization; D015195:Drug Design; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D009757:Nylons / Q000138:chemical synthesis / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry
D003432:Cross-Linking Reagents; D007093:Imidazoles; D009757:Nylons; D009838:Oligodeoxyribonucleotides; D011758:Pyrroles; D004247:DNA