[Effect of calcium antagonists verapamil and amlodipine on the risk of development of atrial fibrillation after coronary artery bypass grafting].
OBJECTIVE
To assess effect of calcium antagonists amlodipine and verapamil on the risk of development of atrial fibrillation after coronary artery bypass surgery.


METHODS
Of 74 patients subjected to mammary artery and venous coronary bypass grafting with the use of cardiopulmonary bypass 19 received amlodipine and 21 - verapamil.


CONCLUSIONS
Attacks of atrial fibrillation during 24 hour ECG monitoring were registered in 22.9% of patients mostly on days 2 and 3 after surgery. In verapamil treated patients atrial fibrillation occurred 1.5-2 times more often than in amlodipine treated patients or in patients receiving no calcium antagonists. This could possibly be explained by pronounced slowing of atrio-ventricular conduction by verapamil at the background of postoperative general "irritation" of the atrial myocardium.
Popov
S V
SV
NII kardiologii Tomskogo nauchnogo tsentra Sibirskogo otdeleniia RAMN, Tomsk.
Kandinskiĭ
M L
ML
Kozlov
B N
BN
Antonchenko
I V
IV
Evtushenko
A V
AV
Dzhavadova
G K
GK
Vecherskiĭ
Iu Iu
IuIu
Akhmedov
Sh D
ShD
Afanas'ev
S A
SA
Shipulin
V M
VM
D000328:Adult; D000368:Aged; D017311:Amlodipine / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000139:chemically induced*; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D001026:Coronary Artery Bypass; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000601:surgery*; D011183:Postoperative Complications / Q000139:chemically induced*; D014700:Verapamil / Q000009:adverse effects*
D002121:Calcium Channel Blockers; D017311:Amlodipine; D014700:Verapamil