Design of intelligent nucleobases and DNA HOMO mapping.
We have designed a new nucleobase, benzodeazaadenine (BDA) that has a stronger charge transport ability than guanine and is not destroyed during charge transport process. By incorporating this new nucleobase into DNA, we demonstrated a protocol for real DNA nano-wire that is far superior to natural DNA. We also demonstrated that the selectivity for the interaction of Mn(II) ion with guanine N7 in G runs is a HOMO-controlled process, and as a consequence, the selectivity for G-metal ion interactions obtained by 15N-NMR studies would directly reflect the HOMO distribution of G-containing sequences in B-DNA.
Saito
Isao
I
Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Kyoto 606-8501, Japan.
D000225:Adenine / Q000031:analogs & derivatives / Q000737:chemistry*; D001483:Base Sequence; D004247:DNA / Q000737:chemistry*
C474395:benzodeazaadenine; D004247:DNA; D000225:Adenine