[Identification and assessment of multiple human papillomavirus types in condyloma acuminata lesions from patients with genital warts in Beijing area].
OBJECTIVE
To identify and assess multiple human papillomavirus types in condyloma acuminatum lesions from patients with genital warts in Beijing area, and compare different features between otherwise healthy and immunosuppressed patients.


METHODS
PCR, RFLP and nucleotide sequencing analysis were used to determine HPV types from individual lesions.


RESULTS
The predominant type from other healthy patients was HPV6, secondly HPV11. The mean age of patients infected by HPV6 was lower than that of HPV11 and HPV6 + 11. While lesions from immunosuppressed patients were often contained HPV11 or mixed with HPV6. Besides, HPV types 16 and 53 were detected from infected lesions than other HPV types.


CONCLUSIONS
HPV6 was the major pathogen of condyloma acuminatum, but infected patients were at lower ages. While HPV11 was most often detected from immunosuppressed patients. As a low risk virus in normal genital tract, HPV53 also could be a pathogen in genital warts.
Hong
Shao-lin
SL
Department of Dermatology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.
Wang
Jia-bi
JB
Liu
Yue-hua
YH
Si
Jing-yi
JY
Xu
Xue-mei
XM
Guo
Xiu-chan
XC
Zeng
Yi
Y
D000328:Adult; D003218:Condylomata Acuminata / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification*; D030361:Papillomavirus Infections; D014412:Tumor Virus Infections; D014860:Warts / Q000821:virology