Relation of local platelet glycoprotein IIb/IIIa independent activation during coronary angioplasty in acute myocardial infarction to recovery of left ventricular function.
We assessed glycoprotein (GP) IIb/IIIa independent platelet activation in coronary sinus and peripheral blood from patients who underwent angioplasty for acute myocardial infarction and stable angina. Despite complete blockade of the activated GP IIb/IIIa receptor with abciximab in patients with acute myocardial infarction, unsuppressed local GP IIb/IIIa independent activation was associated with a lack of recovery of left ventricular function.
Taylor
Andrew J
AJ
Alfred Hospital and Baker Medical Research Institute, Prahan, Melbourne, Australia. andrew.taylor@baker.edu.au
Bobik
Alex
A
Berndt
Michael C
MC
Kalff
Victor
V
Michaelides
Alexandra
A
Jennings
Garry L R
GL
D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease / Q000097:blood / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D015539:Platelet Activation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000502:physiology*; D016277:Ventricular Function, Left
D019039:Platelet Glycoprotein GPIIb-IIIa Complex