title: RETRACTED: Reelin promotes peripheral synapse elimination and maturation.
abstract: Reelin is an extracellular protein that is crucial for layer formation in the embryonic brain. Here, we demonstrate that Reelin functions postnatally to regulate the development of the neuromuscular junction. Reelin is required for motor end-plate maturation and proper nerve-muscle connectivity, and it directly promotes synapse elimination. Unlike layer formation, neuromuscular junction development requires a function of Reelin that is not mediated by Disabled1 or very-low-density lipoprotein receptors and apolipoprotein E receptor 2 receptors but by a distinct mechanism involving its protease activity.
authors.affiliation: The Cain Foundation Laboratories, Houston, TX 77030, USA.
authors.forename: Carlo C
authors.initials: CC
authors.lastname: Quattrocchi
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.forename: Sanyong
authors.initials: S
authors.lastname: Niu
authors.forename: Michael
authors.initials: M
authors.lastname: Sheldon
authors.forename: David
authors.initials: D
authors.lastname: Benhayon
authors.forename: Joiner
authors.initials: J
authors.lastname: Cartwright
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Mosier
authors.forename: Flavio
authors.initials: F
authors.lastname: Keller
authors.forename: Gabriella
authors.initials: G
authors.lastname: D'Arcangelo
mesh_terms: D000200:Action Potentials; D000818:Animals; D001369:Axons / Q000378:metabolism; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D017077:Culture Media, Conditioned; D003964:Diaphragm / Q000294:innervation; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D026502:LDL-Receptor Related Proteins; D051379:Mice; D008818:Mice, Neurologic Mutants; D018613:Microscopy, Confocal; D008854:Microscopy, Electron; D009045:Motor Endplate / Q000648:ultrastructure; D009046:Motor Neurons / Q000378:metabolism; D018482:Muscle, Skeletal / Q000294:innervation; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009469:Neuromuscular Junction / Q000254:growth & development* / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D011973:Receptors, LDL / Q000235:genetics / Q000378:metabolism; D018110:Receptors, Lipoprotein / Q000235:genetics / Q000378:metabolism; D000091042:Reelin Protein; D012583:Schwann Cells / Q000378:metabolism; D012697:Serine Endopeptidases; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology; D013450:Sulfones / Q000494:pharmacology; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D017077:Culture Media, Conditioned; C103773:Dab1 protein, mouse; D016326:Extracellular Matrix Proteins; D026502:LDL-Receptor Related Proteins; D009419:Nerve Tissue Proteins; D011973:Receptors, LDL; D018110:Receptors, Lipoprotein; D000091042:Reelin Protein; D015842:Serine Proteinase Inhibitors; D013450:Sulfones; C036053:VLDL receptor; C098773:low density lipoprotein receptor-related protein 8; C002010:4-(2-aminoethyl)benzenesulfonylfluoride; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases