title: Overuse of high stability antibiotics and its consequences in public and environmental health.
abstract: In this paper the ecological aspects of widespread antibiotic consumption are described. Many practitioners, veterinarians, breeders, farmers and analysts work on the assumption that a antibiotics undergo spontaneous degradation. It is well documented that the indiscriminate use of antibiotics has led to the water contamination, selection and dissemination of antibiotic-resistant organisms, alteration of fragile ecology of the microbial ecosystems. The damages caused by the overuse of antibiotics include hospital, waterborne and foodborne infections by resistant bacteria, enteropathy (irritable bowel syndrome, antibiotic-associated diarrhea etc.), drug hypersensitivity, biosphere alteration, human and animal growth promotion, destruction of fragile interspecific competition in microbial ecosystems etc. The consequences of heavy antibiotic use for public and environmental health are difficult to assess: utilization of antibiotics from the environment and reduction of irrational use is the highest priority issue. This purpose may be accomplished by bioremediation, use of probenecid for antibiotic dosage reduction and by adoption of hospital infections methodology for control resistance in natural ecosystems.
authors.affiliation: Department of Infectious Disease, Medical University, Wrocław, Poland. p.zdziarski@pharmanet.com.pl
authors.forename: Przemysław
authors.initials: P
authors.lastname: Zdziarski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Simon
authors.forename: Jacek
authors.initials: J
authors.lastname: Majda
mesh_terms: D000383:Agriculture; D000818:Animals; D000900:Anti-Bacterial Agents; D024881:Drug Resistance, Bacterial; D017753:Ecosystem; D006801:Humans; D011634:Public Health; D014877:Water Pollution, Chemical
chemical_list: D000900:Anti-Bacterial Agents