[A comparative study of EGFR and FGFR-2 expression in fetal and adult skin].
OBJECTIVE
To observe the expression characteristics of EGFR and FGFR-2 in normal skin from fetal and adult, and attempted to probe the molecule mechanism of fetal scarless healing.


METHODS
The skin samples of fetal and adult were taken from abortive fetus of obstetrics unit and donor site of plastic operation patients in our burn unit, respectively. EGFR and FGFR-2 were used as the biochemical markers for reparative cells. Immunohistochemistry staining technique was employed to determine the expressive levels of different epithelial cells markers.


RESULTS
There were EGFR and FGFR-2 antibody positive cells in normal skin from fetal and adult, but the expressive levels of EGFR and FGFR-2 protein had apparent difference, with the time of fetation increasing, the EGFR and FGFR-2 positive expression rate became stronger gradually. The number of FGFR-2 antibody positive cells found in adult skin was much more than that in fetal skin.


CONCLUSIONS
There were the inherent differences of EGFR and FGFR-2 antibody immunohistochemistry staining in cells of adult and fetal skin. which may be an essential facet of fetal scarless healing.
Cheng
Biao
B
Key Research Laboratory of Wound Repair, PLA, 304th Hospital, Beijing 100037, China.
Fu
Xiao-bing
XB
Sheng
Zhi-yong
ZY
Sun
Tong-zhu
TZ
Sun
Xiao-qing
XQ
D000328:Adult; D004847:Epithelial Cells / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D014945:Wound Healing
D066246:ErbB Receptors; D018719:Erb-b2 Receptor Tyrosine Kinases