title: Investigation of DNA strand exchange mechanisms mediated by cationic polymers.
abstract: It was observed that conjugation of dextran for PLL provided PLL-g-Dex with new properties of enhancing and accelerating inter-nucleotide recognition (1, 2, 3). In this paper, we report the effects of cationic PLL-g-Dex copolymers on base-pair formation of self-complementary octamer oligonucleotide by using NMR and CD analysis. NMR studies revealed that PLL-g-Dex copolymer did not affect hydrogen-bondings between bases in DNA duplex. CD studies also supported inert nature of the copolymer upon hybrid structure.
authors.affiliation: Precursory Research for Embryonic Science and Technology, Japan Science and Technology Corporation, 4-1-8 Honcho, Kawaguti, Saitama 332-0012, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sato
authors.forename: Won Jong
authors.initials: WJ
authors.lastname: Kim
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Choi
authors.forename: Minako
authors.initials: M
authors.lastname: Saito
authors.forename: Arihiro
authors.initials: A
authors.lastname: Kano
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Akaike
authors.forename: Atsushi
authors.initials: A
authors.lastname: Maruyama
mesh_terms: D001483:Base Sequence; D002412:Cations; D004247:DNA / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D002412:Cations; D011108:Polymers; D004247:DNA