Histological examination of the retinal ganglion layer in rabbits after experimental administration of the new immunosuppressive medicine--Cladribine.
The experiment was carried out on rabbit females of New Zealand breed weighing about 3 kg. Animals from the experimental group received Cladribine according to the schema of experimental treatment in the hairy cell leukemia and rabbits from the experimental group II--according to the schema of experimental treatment in multiple sclerosis. Specimens of retina were collected for histological examinations in the light microscope. It was revealed that administration of Cladribine in the dose corresponding to the therapeutic dose used in human for the treatment of the hairy cell leukemia and multiple sclerosis does not cause evident morphological changes in retinal ganglion cells on the level of light microscope.
Kwietniewska
Małgorzata
M
Department of Histology and Embryology, Lab of Experimental Cytology, Medical University of Lublin, Department of Histology and Embryology, Agricultural University of Lublin.
Cybulska
Regina
R
Kwietniewski
Piotr
P
Sekita-Krzak
Joanna
J
Czerny
Krystyna
K
D000818:Animals; D017338:Cladribine / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007943:Leukemia, Hairy Cell / Q000188:drug therapy; D009103:Multiple Sclerosis / Q000188:drug therapy; D011817:Rabbits; D012016:Reference Values; D012162:Retinal Degeneration / Q000139:chemically induced* / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000187:drug effects* / Q000473:pathology*
D007166:Immunosuppressive Agents; D017338:Cladribine