Dead-ended autologous connective tissue chambers in peripheral nerve repair--early observations.
The effects of the repair of nerve gap injuries are still unsatisfactory, despite the great progress in microsurgery. Until now, there is no effective method to induce the regeneration of the transected peripheral nerve when its distal stump is missing. The aim of this work was to examine whether the implantation of dead-ended connective tissue chambers can promote the outgrowth of injured peripheral neurites. This method differs from all previous nerve guides because it totally eliminates the distal part of the nerve and restricts the influence of surrounding tissues. We have also tried to establish whether some neurotrophic factors can be applied by means of these chambers. The results of this work show that dead-ended autologous connective tissue chambers can be a useful tool in peripheral nerve injuries treatment, even when the distal part of the nerve is missing.
Lewin-Kowalik
J
J
Department of Physiology, Medical University of Silesia, Katowice, Poland. fzjkatpl@infomed.slam.katowice.pl
Marcol
W
W
Kotulska-Wolwender
K
K
Larysz-Brysz
M
M
Swiech-Sabuda
E
E
Górka
D
D
Gołka
B
B
Małecka-Tendera
E
E
D020341:Absorbable Implants; D000704:Analysis of Variance; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology*; D003238:Connective Tissue / Q000294:innervation / Q000637:transplantation*; D003714:Denervation; D004343:Drug Implants; D008297:Male; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D016501:Neurites / Q000187:drug effects / Q000502:physiology*; D009482:Neurophysiology / Q000379:methods; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000601:surgery; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000293:injuries / Q000601:surgery*
D019208:Brain-Derived Neurotrophic Factor; D004343:Drug Implants