title: CD34-positive stromal cells in primary lung carcinomas.
abstract: To investigate the phenotypes of stromal cells in primary lung carcinomas, we examined the distribution of CD34-positive stromal cells in primary lung carcinomas, with special reference to histological types. In total 26 surgically resected primary lung carcinomas (13 adenocarcinomas, 10 squamous cell carcinomas, 2 large cell carcinomas, and 1 small cell carcinoma and their normal tissues were examined. CD34-positive stromal cells were observed in connective tissue adjacent to the bronchiolar and bronchial epithelium in normal lung tissues. Nine of the 13 adenocarcinomas had CD34-positive stromal cells in the tumor stroma, whereas none of the other histological type tumors examined had CD34-positive stromal cells. These results suggest that CD34-positive stromal cells are specific in the stroma of primary lung adenocarcinomas, and there is a possibility that CD34-positive stromal cells may play a supportive role in primary lung adenocarcinomas.
authors.affiliation: Department of Molecular Pathology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan. nakayamh@hiroshima-u.ac.jp
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Nakayama
authors.forename: Hideaki
authors.initials: H
authors.lastname: Enzan
authors.forename: Maya
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Eriko
authors.initials: E
authors.lastname: Miyazaki
authors.forename: Chitoshi
authors.initials: C
authors.lastname: Hidaka
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Okumichi
authors.forename: Atsuo
authors.initials: A
authors.lastname: Okumichi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kajihara
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D018952:Antigens, CD34 / Q000096:biosynthesis*; D018287:Carcinoma, Large Cell / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000096:biosynthesis
chemical_list: D018952:Antigens, CD34; D019408:Platelet Endothelial Cell Adhesion Molecule-1