Differential channelling of liver lipids in relation to susceptibility to hepatic steatosis in two species of ducks.
In the human, hepatic steatosis can be associated with an imbalance between synthesis, secretion and storage of hepatic lipids, and exhibits a genetic susceptibility. The effect of overfeeding on hepatic lipid channelling was investigated in two genotypes of ducks that differ in their susceptibility to fatty liver, i.e. the common duck, Anas platyrhynchos, and the Muscovy duck, Cairina moschata. Before overfeeeding, the Muscovy duck exhibited a lower subcutaneous adiposity and a higher muscular development, whereas hepatic composition was similar in both genotypes (>5% lipids and triglycerides accounting for 6-10% lipids). In the plasma lipoprotein profile, HDL predominated (5.5-7.8 g/l) over VLDL (0.09-0.25 g/l) and LDL (0.65-1.06 g/l). All lipid and lipoprotein concentrations were lower in the Muscovy duck. In response to overfeeding, the Muscovy duck exhibited a higher degree of hepatic steatosis (62 vs. 50% lipids), and a lower increase in adiposity and in the concentration of plasma triglycerides (6-fold vs. 10-fold) and VLDL (23-fold vs. 34-fold). Thus, certain genotypes may be more responsive to the dietary induction of fatty liver because of a less efficient channelling of hepatic lipids towards secretion into plasma and adipose storage, and the duck may represent a suitable model in which to study the development of hepatic steatosis and its pathogenesis.
Hermier
Dominique
D
Laboratoire de Physiologie de la Nutrition-INRA, Bâtiment 447, Centre Scientifique d'Orsay, Orsay 91405, France. dominique.hermier@ibaic.u-psud.fr
Guy
Gérard
G
Guillaumin
Solange
S
Davail
Stéphane
S
André
Jean-Marc
JM
Hoo-Paris
Robert
R
D000818:Animals; D001835:Body Weight; D004032:Diet; D004198:Disease Susceptibility; D004372:Ducks / Q000502:physiology*; D005234:Fatty Liver / Q000235:genetics / Q000378:metabolism*; D005838:Genotype; D006801:Humans; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D008297:Male; D018482:Muscle, Skeletal / Q000737:chemistry / Q000378:metabolism; D009929:Organ Size
D008074:Lipoproteins