[Two hypotheses about preeclampsia: endothelium injury and inflammation].
The paper is a survey of literature on the two hypotheses about preeclampsia: a) one according to which the endothelium injury is a key complication; b) another one according to which the injury is a side effect of inflammation and adhesive reaction. Those reactions consist in the activation of the endothelium and activation of blood platelets, as well as activation of neutrophils and monocytes/macrophages. That complex activation is induced by cytokines and integrins from the placenta, deported cytotrophoblast and procoagulant debris of the trophoblast. The two hypotheses are complementary rather than competitive.
Uszyński
Waldemar
W
Katedry i Zakładu Propedeutyki Medycyny Akademii Medycznej w Bydgoszczy.
Uszyński
Mieczysław
M
D001792:Blood Platelets / Q000378:metabolism; D004730:Endothelium, Vascular / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008264:Macrophages / Q000378:metabolism; D009000:Monocytes / Q000378:metabolism; D018375:Neutrophil Activation; D010920:Placenta / Q000378:metabolism; D015539:Platelet Activation; D011225:Pre-Eclampsia / Q000276:immunology / Q000378:metabolism*; D011247:Pregnancy