title: Increased neurogenesis after experimental Streptococcus pneumoniae meningitis.
abstract: Neuronal damage in the hippocampal formation is a common feature in animal models of bacterial meningitis and human disease. In mouse and rabbit models of Streptococcus pneumoniae meningitis, proliferation of neural progenitor cells quantified by bromodeoxyuridine (BrdU) incorporation was enhanced in the subgranular layer of the dentate gyrus. In mice, the density of BrdU-labeled cells was maximal on Day 2 after infection. Approximately 60% of the cells labeled by BrdU between Days 7 and 10 after infection that remained present 28 days later had migrated into deeper layers of the dentate gyrus and differentiated into neurons, as evidenced by immunohistochemical staining for TUC-4, MAP-2 and beta-tubulin. This suggests that endogenous repair mechanisms may limit consequences of neuronal destruction after meningitis.
authors.affiliation: Department of Neurology, Georg-August-University, Göttingen, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Gerber
authors.forename: Tobias
authors.initials: T
authors.lastname: Böttcher
authors.forename: Judith
authors.initials: J
authors.lastname: Bering
authors.forename: Stephanie
authors.initials: S
authors.lastname: Bunkowski
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Brück
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kuhnt
authors.forename: Roland
authors.initials: R
authors.lastname: Nau
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001973:Bromodeoxyuridine / Q000493:pharmacokinetics; D002452:Cell Count; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D018891:Dentate Gyrus / Q000166:cytology / Q000378:metabolism* / Q000382:microbiology; D004195:Disease Models, Animal; D007150:Immunohistochemistry / Q000379:methods; D017403:In Situ Hybridization; D007239:Infections / Q000382:microbiology; D008297:Male; D008586:Meningitis, Pneumococcal / Q000382:microbiology / Q000503:physiopathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011817:Rabbits; D013234:Stem Cells / Q000502:physiology*; D013290:Streptococcal Infections / Q000503:physiopathology*; D013296:Streptococcus pneumoniae; D013997:Time Factors; D014404:Tubulin / Q000378:metabolism
chemical_list: D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D014404:Tubulin; D001973:Bromodeoxyuridine