[Combination chemotherapy with nedaplatin and 5-fluorouracil for oral squamous cell carcinomas].
We used a new combination chemotherapy with nedaplatin (CDGP) and 5-fluorouracil (5-FU) in eleven fresh patients with oral squamous cell carcinomas. 5-FU was administered at a dose of 1,000 mg/body by continuous infusion for 24 hours on days 1 to 5. CDGP was administered at a dose of 80 or 100 mg/m2 by drip infusion for 120 minutes on day 5. The response rates of total (1- or 2-course) and 2-course group were 54. 5% and 83.3%, respectively. Adverse drug reactions were limited to two cases of grade 3 toxicity with anorexia. The combination chemotherapy with 5-FU and CDGP in place of cisplatin and 5-FU seemed to play an important role as neo-adjuvant chemotherapy for oral squamous cell carcinomas.
Yamaoka
Kaoru
K
Division of Dentistry and Oral Surgery, Akita University School of Medicine.
Fukuda
Masayuki
M
Kuwajima
Seiichi
S
Hagiwara
Hisako
H
Toshima
Shinichi
S
Matsuoka
Atsushi
A
Ohnuki
Takayoshi
T
Seki
Hiroshi
H
Nagai
Hirokazu
H
Iino
Mitsuyoshi
M
Sageshima
Masato
M
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy*; D009944:Organoplatinum Compounds / Q000008:administration & dosage
D009944:Organoplatinum Compounds; C053989:nedaplatin; D005472:Fluorouracil