Tuning exocytosis for speed: fast and slow modes.
Exocytic fusion reactions triggered by Ca(2+) are widespread in neural, endocrine, exocrine, hemapoetic and perhaps all cell types. These processes exhibit tremendous variation in latencies to fusion following a Ca(2+) rise and in rates of fusion. We review reported differences for synaptic vesicle (SV) and dense-core vesicle (DCV) exocytosis and attempt to identify key features in the molecular mechanisms of docking, priming and fusion of SVs and DCVs that may account for differences in speed.
Martin
Thomas F J
TF
Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA. tfmartin@facstaff.wisc.edu
D000818:Animals; D002118:Calcium / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology*; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D022142:Secretory Vesicles / Q000502:physiology*; D013572:Synaptic Vesicles / Q000502:physiology*
D002118:Calcium