title: An efficient synthesis of the C-23 deoxy, 17 alpha-hydroxy South 1 hemisphere and its cephalostatin 1 analog.
abstract: [reaction: see text] Methods for functionalization of the D ring of diene 1 were investigated. This study led to efficient syntheses of 3 and the subsequent 23'-deoxy,17'alpha-hydroxy cephalostatin 1 analog (4). The bioactivity data of 2 and 4 are in the low nanomolar range for a 10-cell-line minipanel.
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Philip L
authors.initials: PL
authors.lastname: Fuchs
mesh_terms: D002460:Cell Line; D010619:Phenazines / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013256:Steroids
chemical_list: D010619:Phenazines; D013141:Spiro Compounds; D013256:Steroids; C454806:cephalostatin I