The emerging role of lysophosphatidic acid in cancer.
The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.
Mills
Gordon B
GB
MD Anderson Cancer Center, Houston, Texas 77030, USA. gmills@mdanderson.org
Moolenaar
Wouter H
WH
D014408:Biomarkers, Tumor / Q000032:analysis; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008246:Lysophospholipids / Q000032:analysis / Q000737:chemistry / Q000502:physiology*; D009369:Neoplasms / Q000175:diagnosis / Q000209:etiology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled; D049368:Receptors, Lysophosphatidic Acid; D015398:Signal Transduction
D014408:Biomarkers, Tumor; D008246:Lysophospholipids; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D049368:Receptors, Lysophosphatidic Acid; D020962:Heterotrimeric GTP-Binding Proteins