Regulation of septin organization and function in yeast.
Septins are a conserved eukaryotic family of GTP-binding filament-forming proteins with functions in cytokinesis and other processes. In the budding yeast Saccharomyces cerevisiae, septins initially localize to the presumptive bud site and then to the cortex of the mother-bud neck as an hourglass structure. During cytokinesis, the septin hourglass splits and single septin rings partition with each of the resulting cells. Septins are thought to function in diverse processes in S. cerevisiae, mainly by acting as a scaffold to direct the neck localization of septin-associated proteins.
Longtine
Mark S
MS
Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK 74075-3035, USA.
Bi
Erfei
E
D018797:Cell Cycle Proteins / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000502:physiology*; D005089:Exocytosis / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics / Q000502:physiology; D004718:Saccharomycetales / Q000166:cytology / Q000235:genetics / Q000502:physiology*; D008941:Spindle Apparatus / Q000502:physiology; D020846:cdc42 GTP-Binding Protein, Saccharomyces cerevisiae / Q000502:physiology
D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; D019204:GTP-Binding Proteins; D020846:cdc42 GTP-Binding Protein, Saccharomyces cerevisiae