[Assessment of preoperative localization techniques for patients with primary hyperparathyroidism].
OBJECTIVE
To evaluate the sensitivity and usefulness of 99mTc-sestamibi scintigraphy (SS) and neck ultrasonography (US) as preoperative localization procedures in patients with primary hyperparathyroidism (pHPT).


METHODS
160 patients with proved pHPT in Peking Union Medical College Hospital from June 1983 to June 2002 were studied. There were 107 women(66.9%) and 53 men (33.1%), with a mean age of 38.9 years (10-73 years). 100 patients were underwent SS and 148 patients were underwent US prior to surgery, and the results were compared with operative and histological findings.


RESULTS
The sensitivity of SS and US in localization of the enlarged parathyroid glands was 94.0% and 85.1% respectively, and the positive predictive value of SS and US was 100% and 89.1% respectively, the overall sensitivity was 98.9% by combination of SS and US. In solitary parathyroid adenomas group (n = 145), the sensitivity of SS and US was 93.3% and 84.7% respectively; There was no significant difference (P = 0.428) in sensitivity of SS between the parathyroid glands correctly identified and undetected in classical neck location as compared with ectopic parathyroid glands, whereas significantly (P = 0.026) influenced by the US sensitivity.


CONCLUSIONS
Different sensitivity exit between SS and VS in preoperative localization in patients with pHPT undergoing parathyroidectomy. The combined use of SS and US could increase the sensitivity of localization technique. Ectopic parathyroid had no influence on the sensitivity of 99mTc-MIBI scanning, but decreased the sensitivity of ultrasonography. The size of parathyroid tumors had effects on the sensitivity of ultrasonography. Otherwise, various conditions causing SS false negative were observed. Some interfere factors should be excluded when SS negative results were encountered in clinical practice.
Ning
Zhi-wei
ZW
Department of Endocrinology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China. ningzhw@csc.pumch.ac.cn
Wang
Ou
O
Xu
Jing-ying
JY
Zhang
Jin-xi
JX
Li
Fang
F
Xing
Xiao-ping
XP
Meng
Xun-wu
XW
Xia
Wei-bo
WB
Li
Mei
M
Guan
Heng
H
Zhu
Yu
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000000981:diagnostic imaging; D010280:Parathyroid Glands / Q000000981:diagnostic imaging / Q000473:pathology*; D011300:Preoperative Care; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi / Q000627:therapeutic use*; D014463:Ultrasonography
D017256:Technetium Tc 99m Sestamibi