title: Plasma cytokine profiles in patients with celiac disease and selective IgA deficiency.
abstract: Celiac disease (CD) and selective IgA deficiency (IgAD) are frequently associated, and share the same genetic background. The aim of the present study was to evaluate both Type 1 and 2 plasma cytokine levels in CD and in CD-IgAD. IL-2, TNF-alpha, IL-10, IL-4 and IL-13 plasma levels were measured both at diagnosis and after a gluten-free diet (GFD) in 32 CD patients, in 27 CD-IgAD patients and in 30 healthy controls. IFN-gamma levels were significantly higher in CD and CD-IgAD than in controls, TNF-alpha displayed significantly higher levels in CD-IgAD when compared both with controls and with CD, and IL-2 was in CD-IgAD significantly increased respect to controls. Kinetics of the Type 1 cytokine plasma levels did not show a clear relationship with the GFD in both groups of CD patients, and particularly in those with IgAD. IL-4 and IL-13, both at diagnosis and after a GFD, were not significantly different in controls and in celiac patients (with and without IgAD). IL-10, whose production is stimulated by the TNF-alpha, had significantly higher plasma levels in CD-IgAD, but not in CD patients, with a significant decrease after a GFD. CD and especially CD-IgAD patients display persistently higher pro-inflammatory cytokine levels, suggesting a persistent state of activation of pro-phlogistic signals in CD, particularly when IgAD coexists. Serial measurement of serum IL-10 may be an adjunctive evaluating criterion in the follow-up of CD-IgAD patients.
authors.affiliation: Clinica Pediatrica R, University of Palermo, Palermo, Italy. cescocat@freemail.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Cataldo
authors.forename: Domenico
authors.initials: D
authors.lastname: Lio
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Marino
authors.forename: Letizia
authors.initials: L
authors.lastname: Scola
authors.forename: Antonio
authors.initials: A
authors.lastname: Crivello
authors.forename: G R
authors.initials: GR
authors.lastname: Corazza
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002446:Celiac Disease / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004032:Diet; D005260:Female; D005983:Glutens / Q000008:administration & dosage; D006801:Humans; D017098:IgA Deficiency / Q000097:blood*; D007223:Infant; D018836:Inflammation Mediators / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D018793:Interleukin-13 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D018793:Interleukin-13; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D015847:Interleukin-4; D005983:Glutens