title: Isolation and identification of sodium 2-propenyl thiosulfate from boiled garlic (Allium sativum) that oxidizes canine erythrocytes.
abstract: Sodium 2-propenyl thiosulfate was identified in boiled garlic (Allium sativum). When canine erythrocytes were incubated with sodium 2-propenyl thiosulfate, the methemoglobin concentration and Heinz body percentage in erythrocytes were both increased, indicating that the compound induced oxidative damage in canine erythrocytes. It seems that this compound is one of the causative agents of garlic-induced hemolysis in dogs.
authors.affiliation: Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan. osam@vetmed.hokudai.ac.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamato
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Matsuura
authors.forename: Keun-Woo
authors.initials: KW
authors.lastname: Lee
authors.forename: Koichi
authors.initials: K
authors.lastname: Goto
authors.forename: Mohammad Alamgir
authors.initials: MA
authors.lastname: Hossain
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Maede
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Yoshihara
mesh_terms: D000818:Animals; D004285:Dogs; D004912:Erythrocytes / Q000187:drug effects*; D005737:Garlic / Q000737:chemistry*; D006366:Heinz Bodies / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008706:Methemoglobin / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry; D013885:Thiosulfates / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D013885:Thiosulfates; D008706:Methemoglobin; C017717:sodium thiosulfate