[Study of uncoupling protein-2 gene expression in intraperitoneal adipose tissue of obese humans and normal humans].
In order to determine UCP-2 mRNA levels in intraperitoneal adipose tissue of obese and no-obese humans and its role in the pathogenesis of obesity in humans, RT-PCR method was used for studying UCP-2 mRNA expression in intraperitoneal adipose tissue of 31 obese subjects (BMI > 25) and 34 no-obese subjects (BMI18.5-24). The results showed that compared with no-obese subjects, both male and female obese subjects displayed significantly lower average UCP-2 mRNA expression in the intraperitoneal adipose tissue (P < 0.05). It is concluded that UCP-2 may play a role in the pathophysiology of obesity.
You
Yue
Y
Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Yang
Yiliang
Y
Zhang
Shuhai
S
Zhao
Wenhua
W
Yang
Xiaoguang
X
D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D005260:Female; D015870:Gene Expression; D006801:Humans; D007473:Ion Channels; D008297:Male; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000071246:Uncoupling Protein 2
D007473:Ion Channels; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D012333:RNA, Messenger; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2