[Gene expression of the MAGE-1, -3, and -6 antigens in hepatic carcinoma].
MAGE is a family of genes specifically associated to human melanoma, but also found in hepatocellular carcinoma (HCC). In this study we evaluated the expression of such genes in 41 HCC patients, their correlation with pathological and clinical aspects of cancer, and the impact on prognosis. MAGE are expressed in most of HCC samples (28/41), no correlation was found with type and stage but they may be used as potential target for IT.
Lupo
L
L
Dipartimento Emergenza e Trapianto d'Organi, Unità di Chirurgia Generale e Trapianto di Fegato, Università di Bari.
Ranieri
E
E
Rotelli
M T
MT
Aquilino
F
F
D'Elia
G
G
Gallerani
A
A
Di Palma
G
G
Memeo
V
V
D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000096:biosynthesis / Q000235:genetics*; D019496:Cancer Vaccines; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D008297:Male; D058950:Melanoma-Specific Antigens; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics*; D011446:Prospective Studies
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; C072011:MAGEA1 protein, human; C072013:MAGEA3 protein, human; C095203:MAGEA6 protein, human; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins