title: [Syndrome of impaired tolerance to dietary fats in coronary heart disease].
abstract: Changes of main lipid and apolipoprotein parameters of lipid transport system during postprandial hyperlipidemia were studied in subjects without (n=72) and with (n=167) overt coronary heart disease (CHD) including patients with noninsulin dependent diabetes (n=48). Tolerance to dietary fat was evaluated by oral fat load test (consumption of 639+/-7 ml of 20% cream after fast). In subjects without CHD reaction of lipid transport system to fat load was characterized by lowered total, low density lipoprotein cholesterol, apolipoprotein apo B and apo B/apo A-1 ratio, lowered or unchanged triglycerides, stable high density lipoprotein cholesterol level at the background of apo A-1 elevation by 6-th hour after load. Patients with CHD exhibited signs of impaired tolerance to dietary fat: elevation of triglycerides, apo B and apo B/apo A-1 ratio, lowering of high density lipoprotein cholesterol, increase of percentage of subfractions of small high density lipoproteins particles, increase of triglyceride content in low and high density lipoprotein fraction during 6 hours after fat load.
authors.forename: M G
authors.initials: MG
authors.lastname: Bubnova
authors.forename: N V
authors.initials: NV
authors.lastname: Perova
authors.forename: D M
authors.initials: DM
authors.lastname: Aronov
authors.forename: A M
authors.initials: AM
authors.lastname: Olfer'ev
authors.forename: R G
authors.initials: RG
authors.lastname: Oganov
mesh_terms: D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D004041:Dietary Fats / Q000008:administration & dosage*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000150:complications; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D013577:Syndrome
chemical_list: D001053:Apolipoproteins; D004041:Dietary Fats; D008075:Lipoproteins, HDL