Monoamine oxidase A gene polymorphism, 5-HT 2A receptor gene polymorphism and incidence of nausea induced by fluvoxamine.
Selective serotonin reuptake inhibitors cause a side effect of nausea with high frequency, but there have been no accurate methods to predict its incidence. The authors first investigated whether a functional polymorphism in the monoamine oxidase A (MAOA-VNTR) and a -1438G/A polymorphism in the promoter region of the 5-HT(2A) gene were associated with the incidence of nausea induced by fluvoxamine. Fluvoxamine was administered for 6 weeks with a specific dosage plan (50-200 mg/day) in 66 Japanese major depressive patients. The frequency of MAOA-VNTR allele 1 was significantly higher in the patients without nausea than in ones with nausea in the statistical analysis including the patients whose plasma levels were below the average and who were considered to be pharmacodynamically more sensitive to nausea. This study showed that the genetic polymorphism of MAOA-VNTR might affect the incidence of nausea induced by SSRIs. If this finding is replicated in other studies with more subjects, MAOA-VNTR polymorphism would be of great clinical use to predict the incidence of nausea induced by SSRIs.
Yoshida
Keizo
K
Department of Psychiatry, Akita University School of Medicine, Akita, Japan. cxw01076@nifty.com
Naito
Shingo
S
Takahashi
Hitoshi
H
Sato
Kazuhiro
K
Ito
Kenichi
K
Kamata
Mitsuhiro
M
Higuchi
Hisashi
H
Shimizu
Tetsuo
T
Itoh
Kunihiko
K
Inoue
Kazuyuki
K
Suzuki
Toshio
T
Ohkubo
Tadashi
T
D000328:Adult; D000368:Aged; D000409:Alanine / Q000235:genetics; D000704:Analysis of Variance; D004334:Drug Administration Schedule; D005260:Female; D016666:Fluvoxamine / Q000009:adverse effects* / Q000097:blood; D005787:Gene Frequency; D005838:Genotype; D005998:Glycine / Q000235:genetics; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D008995:Monoamine Oxidase / Q000235:genetics*; D009325:Nausea / Q000139:chemically induced / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012702:Serotonin Antagonists / Q000009:adverse effects* / Q000097:blood
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D008995:Monoamine Oxidase; D016666:Fluvoxamine; D000409:Alanine; D005998:Glycine