title: Occurrence of hematogenous metastasis and serum levels of thymidine phosphorylase in colorectal cancer.
abstract: Thymidine phosphorylase (dThdPase) is known to promote the development of new blood vessels. Increased dThdPase expression in solid tumors has been shown to correlate with tumor growth, invasion and metastasis. In the present study, we measured dThdPase levels in the tumor tissue and in the serum from the tumor drainage and peripheral venous blood obtained from patients with resectable colorectal cancer. Serum dThdPase levels, measured by a modified ELISA method, were significantly higher in patients with hematogenous metastasis. In the tumor tissue specimens, no significant difference was observed between patients with or without hematogenous metastasis. These results suggest that the serum dThdPase levels are a novel marker to predict occurrence of hematogenous metastasis in patients with resectable colorectal cancer.
authors.affiliation: Department of Surgery, Graduate School of Biochemical Sciences, Nagasaki University, Nagasaki 852-8501, Japan. haraguci@mb.ejnet.ne.jp
authors.forename: Masashi
authors.initials: M
authors.lastname: Haraguchi
authors.forename: Ko
authors.initials: K
authors.lastname: Komuta
authors.forename: Arifumi
authors.initials: A
authors.lastname: Akashi
authors.forename: Junichiro
authors.initials: J
authors.lastname: Furui
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanematsu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000096:biosynthesis; D015214:Antigens, Differentiation, Myelomonocytic / Q000096:biosynthesis; D015179:Colorectal Neoplasms / Q000097:blood / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic; D013939:Thymidine Phosphorylase / Q000097:blood*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D013939:Thymidine Phosphorylase; C067980:CD68 antigen, human; D000097382:CD68 Molecule