Hyperresponsiveness to phencyclidine in animals lesioned in the amygdala on day 7 of life. Implications for an animal model of schizophrenia.
Phencyclidine (PCP) has been described to exacerbate psychotic symptoms in patients suffering from schizophrenia. In rats, PCP, dose-dependently, induces hyperactivity, stereotyped behaviour and social isolation, postulated to represent the positive (hyperactivity, stereotypy) and negative (social isolation) symptoms of schizophrenia. Based on previous studies, ibotenic acid lesions in the amygdala on day 7 of life have been proposed as an animal model of psychiatric neurodevelopmental disorders like schizophrenia. The purpose of the present study was to determine whether the responsiveness to PCP on locomotor activity in animals lesioned in the amygdala on day 7 of life is different from the response to this drug in sham-operated animals. The effect of graded doses of PCP on behaviour was assessed in a small open field. Animals lesioned in the amygdala on day 7 of life appeared to be hyperresponsive to PCP compared to sham-operated animals. The hyperresponsiveness to PCP in rats lesioned in the amygdala on day 7 of life further contributes to the validation of this putative animal model of schizophrenia.
Daenen
E W P M
EW
Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Pharmacology and Anatomy, P.O. Box 85060, 3508 AB Utrecht, The Netherlands.
Wolterink
G
G
Van Ree
J M
JM
D000679:Amygdala / Q000293:injuries*; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000209:etiology*; D004434:Early Ambulation / Q000662:veterinary; D018691:Excitatory Amino Acid Antagonists / Q000009:adverse effects*; D005106:Exploratory Behavior; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D006948:Hyperkinesis; D008297:Male; D009043:Motor Activity; D010622:Phencyclidine / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D012559:Schizophrenia / Q000139:chemically induced / Q000503:physiopathology*; D013239:Stereotyped Behavior
D018691:Excitatory Amino Acid Antagonists; D010622:Phencyclidine