title: [Association of calcitonin receptor gene polymorphism with bone mineral density in Shanghai women].
abstract: OBJECTIVE
  To investigate the association of calcitonin receptor (CTR) gene polymorphism with bone mineral density (BMD) in premenopausal and postmenopausal women.
  
  
  METHODS
  CTR genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 184 premenopausal women and 199 postmenopausal women in Shanghai area. BMD at lumbar spine (L2-4) and femoral neck (FN) were measured by dual-energy X-ray absorptiometry (DEXA).
  
  
  RESULTS
  The distribution of CTR genotypes in 383 Shanghai women were CC genotype 83.8%, TC genotype 14.6%, TT genotype 1.6%, respectively. BMD at FN of CC genotype was significantly higher than TC and TT genotypes (P < 0.01) in postmenopausal women. But there was no difference in BMD of different CTR genotypes in premenopausal women. Multiple regression analysis showed that CTR genotypes were associated with FN BMD in postmenopausal women (P < 0.05).
  
  
  CONCLUSIONS
  The polymorphism of CTR gene was associated with BMD in postmenopausal women.
authors.affiliation: Department of Endocrinology, Ruijin Hospital, Shanghai Second Medical University, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai 200025, China. zhyan725@hotmail.com
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Zhao
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Liu
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
authors.forename: Lian-zhen
authors.initials: LZ
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Jiang
authors.forename: Meng
authors.initials: M
authors.lastname: Dai
authors.forename: Man-yin
authors.initials: MY
authors.lastname: Xu
authors.forename: Jia-lun
authors.initials: JL
authors.lastname: Chen
mesh_terms: D000328:Adult; D000483:Alleles; D015519:Bone Density; D005260:Female; D005272:Femur Neck; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D017698:Postmenopause; D017697:Premenopause; D018003:Receptors, Calcitonin / Q000235:genetics*
chemical_list: D018003:Receptors, Calcitonin