Difference of rejection in single versus combined pancreas and kidney transplantation in rats.
OBJECTIVE
To investigate the difference of rejection in single versus combined pancreas and kidney transplantation in rats.


METHODS
Allograft models including simultaneous pancreas and kidney (SPK) transplant and pancreas or kidney transplant alone were established in SD-Wistar rats, rejections of pancreas and kidney in different models were compared morphologically and functionally.


RESULTS
Mean survival time (MST) of pancreas was significantly prolonged in SPK than in pancreas transplant alone (PTA) (11.5 days vs. 9.2 days, P < 0.05). Incidence of interstitial pancreatic rejection at gade II and grade III was much obvious in PTA than in SPK (42.9% vs. 12.5% at grade II and 28.6% vs 6.3% at grade II , P < 0.05). No significant difference was found in MST between SPK and kidney transplant alone( KTA). Administration of cyclosporine A prolonged the MST of pancreas and kidney, without altering the tendency stated above.


CONCLUSIONS
In SPK, the function of pancreas is protected by kidney hence the severity of rejection is reduced, whereas the function of kidney is not protected by pancreas. It suggests that different organs differ in immunoallergization and immunoregulation, and immune response tend to attack organs with greater immunoactivity, those organs with minor one could be protected. Cyclosporine A is effective on prolonging the MST of pancreas and kidney.
Qiao
H
H
Department of General Surgery, First Clinical Medical School of Harbin Medical University, Harbin 150001.
Jiang
H
H
Dai
W
W
Zhu
Y
Y
Xiao
Y
Y
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D006084:Graft Rejection / Q000097:blood; D006085:Graft Survival; D016030:Kidney Transplantation / Q000276:immunology / Q000401:mortality; D008297:Male; D016035:Pancreas Transplantation / Q000276:immunology / Q000401:mortality; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar
D001786:Blood Glucose