Ciprofloxacin-induced acute interstitial nephritis and autoimmune hemolytic anemia.
Ciprofloxacin has been associated with several side effects including interstitial nephritis and hemolytic anemia. The combination of both side effects is extremely rare. In this report, we describe a case of ciprofloxacin-induced interstitial nephritis and autoimmune hemolytic anemia. Hemolytic anemia improved after stopping the drug and initiation of steroid therapy. Unfortunately, acute interstitial nephritis was irreversible and the patient developed end-stage renal disease.
Lim
Salim
S
Division of Renal Medicine, Department of Internal Medicine, Tan Tock Seng Hospital, Singapore, Singapore. Salim_Lim@ttsh.com.sg
Alam
Muhammad G
MG
D000208:Acute Disease; D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced* / Q000201:enzymology; D000890:Anti-Infective Agents / Q000009:adverse effects*; D002939:Ciprofloxacin / Q000009:adverse effects*; D005954:Glucosephosphate Dehydrogenase / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000201:enzymology
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D005954:Glucosephosphate Dehydrogenase