Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994.
BACKGROUND
In adults the metabolic syndrome imposes a substantial risk for type 2 diabetes mellitus and premature coronary heart disease. Even so, no national estimate is currently available of the prevalence of this syndrome in adolescents.


OBJECTIVE
To estimate the prevalence and distribution of a metabolic syndrome among adolescents in the United States.


METHODS
Analyses of cross-sectional data obtained from the Third National Health and Nutrition Examination Survey (1988-1994), which was administered to a representative sample of the noninstitutionalized civilian population of the United States.


METHODS
Male and female respondents aged 12 to 19 years (n = 2430).


METHODS
The prevalence and distribution of a metabolic syndrome among US adolescents, using the National Cholesterol Education Program (Adult Treatment Panel III) definition modified for age.


RESULTS
The overall prevalence of the metabolic syndrome among adolescents aged 12 to 19 years was 4.2%; 6.1% of males and 2.1% of females were affected (P=.01). The syndrome was present in 28.7% of overweight adolescents (body mass index [BMI], >/=95th percentile) compared with 6.8% of at-risk adolescents (BMI, 85th to <95th percentile) and 0.1% of those with a BMI below the 85th percentile (P<.001). Based on population-weighted estimates, approximately 910 000 US adolescents have the metabolic syndrome.


CONCLUSIONS
Perhaps 4% of adolescents and nearly 30% of overweight adolescents in the United States meet these criteria for a metabolic syndrome, a constellation of metabolic derangements associated with obesity. These findings may have significant implications for both public health and clinical interventions directed at this high-risk group of mostly overweight young people.
Cook
Stephen
S
Strong Children's Research Center, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY 14642, USA. stephen_cook@urmc.rochester.edu
Weitzman
Michael
M
Auinger
Peggy
P
Nguyen
Michael
M
Dietz
William H
WH
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D010641:Phenotype; D015995:Prevalence; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology