The aging of the retina.
This mini-review summarizes our current knowledge concerning the age-related changes that affect the retina. Over the last 10 years, our understanding of the genetics of hereditary retinal diseases has improved considerably. However, the modifications that occur in the retina as a result of aging are still under investigation. In this review, we place particular emphasis on the normal retinal alterations that occur with aging (gene modulation; psychophysical, structural and cellular alterations). We describe the events that occur during the pathological aging process, such as in age-related macular degeneration. Understanding these different modifications is essential if we are to find key players on which to base therapeutic interventions that may help to prevent the passage of normal aging process to the pathological aging process.
Bonnel
Sébastien
S
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, 28 rue de Charenton, F-75012 Paris, France.
Mohand-Said
Saddek
S
Sahel
José-Alain
JA
D000368:Aged; D000375:Aging / Q000502:physiology*; D043924:Angiogenesis Modulating Agents / Q000627:therapeutic use; D006801:Humans; D008268:Macular Degeneration / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D011601:Psychophysics; D012160:Retina / Q000473:pathology / Q000502:physiology* / Q000503:physiopathology; D012164:Retinal Diseases / Q000473:pathology / Q000503:physiopathology*; D014785:Vision, Ocular / Q000502:physiology
D043924:Angiogenesis Modulating Agents