title: [Heat shock proteins as chaperones of the immune response. The optimal stress of life].
abstract: The author reviews the complex role of heat-shock proteins during the immune reaction, especially the cellular effects of heat-shock proteins during recognition processes by innate immunity. The pathogenetic role of heat-shock proteins in two multifactorial diseases, inflammatory bowel disease and atherosclerosis, is summarized. A new hypothesis is presented dealing with the "immunodeficiency burden" as the aggregate effect of the genetic polymorphisms resulting in disease susceptibility. According to this mechanism the aggregate effect of polymorphisms resulting in failure of protective immunity determines the susceptibility for the disease in the given subject, when a specific environmental factor is present.
authors.affiliation: Semmelweis Egyetem, Altalános Orvostudományi Kar, III. sz. Belgyógyászati Klinika, Budapest. prohoz@kut.sote.hu
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Prohászka
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D001161:Arteriosclerosis / Q000276:immunology; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology; D008070:Lipopolysaccharides / Q000378:metabolism; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic / Q000378:metabolism; D013312:Stress, Physiological / Q000276:immunology*; D051193:Toll-Like Receptors
chemical_list: D015703:Antigens, CD; D006360:Heat-Shock Proteins; C475476:LRP1 protein, human; D008070:Lipopolysaccharides; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D051193:Toll-Like Receptors