title: Progressive multifocal leukoencephalopathy in a lung transplant recipient.
abstract: Progressive multifocal leukoencephalopathy (PML) is a sub-acute, demyelinating disease of the brain caused by a human polyomavirus. We describe a patient with the onset of PML 7 months after lung transplantation. The patient was treated with immunosuppressive modulation and cidofovir, a new anti-viral therapy for PML, with stabilization of the symptoms. We also review the 4 additional reports in the literature of PML after heart and lung transplantation. Progressive multifocal leukoencephalopathy may become more prevalent as the population of heart and lung transplantation recipients increases.
authors.affiliation: Pulmonary Institute, Rabin Medical Center, Sackler School of Medicine, Tel Aviv University, Petah Tivka, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Shitrit
authors.forename: Lev
authors.initials: L
authors.lastname: Nirit
authors.forename: Sheely I
authors.initials: SI
authors.lastname: Shiran
authors.forename: Gabriel
authors.initials: G
authors.lastname: Izbicki
authors.forename: Dov
authors.initials: D
authors.lastname: Sofer
authors.forename: Melamed
authors.initials: M
authors.lastname: Eldad
authors.forename: Mordechai R
authors.initials: MR
authors.lastname: Kramer
mesh_terms: D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged