title: Relationship between human lymphocyte antigen-B27 and clinical features of psoriatic arthritis.
abstract: Psoriatic arthritis is a chronic destructive joint disease. About 40% of psoriatic arthritis patients are positive for human lymphocyte antigens (HLA)-B27. This study investigated the relationship between HLA-B27 and clinical manifestations and prognosis in psoriatic arthritis patients. Demographic, clinical, and laboratory data were analyzed from 41 psoriatic arthritis patients with regular follow-ups. The mean percentage of HLA-B27 in psoriatic arthritis was about 39%. Positive HLA-B27 was associated with an increased risk of development of sacroillitis (relative risk 8.75; p<0.01) but not peripheral arthritis (p=0.925). Psoriatic arthritis patients with psoriatic nail disease (41.5% vs 2.4%, p<0.01) and distal interphalangeal joints involvement (26.8% vs 3.4%, p<0.05) had significantly increased risk of developing deformed joints. Psoriatic arthritis patients with positive HLA-B27 tend to develop deformed joints (p=0.068) as well as having elevated levels of C-reactive protein (p=0.072), although these results did not attain significance. HLA-B27 antigen may serve as a useful predictive marker for the development of sacroiliitis in Taiwan.
authors.affiliation: Department of Pediatrics, Christian Hospital, Changhua, ROC.
authors.forename: Yi-Giien
authors.initials: YG
authors.lastname: Tsai
authors.forename: Deh-Ming
authors.initials: DM
authors.lastname: Chang
authors.forename: San-Yuan
authors.initials: SY
authors.lastname: Kuo
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Wang
authors.forename: Yi-Chueng
authors.initials: YC
authors.lastname: Chen
authors.forename: Jenn-Haung
authors.initials: JH
authors.lastname: Lai
mesh_terms: D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000097:blood / Q000276:immunology* / Q000473:pathology; D001799:Blood Sedimentation; D002097:C-Reactive Protein; D005260:Female; D015796:HLA-B27 Antigen / Q000032:analysis*; D006801:Humans; D007596:Joints / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D015796:HLA-B27 Antigen; D002097:C-Reactive Protein