title: The scope of catalytic enantioselective tandem carbonyl ylide formation-intramolecular [3 + 2] cycloadditions.
abstract: Catalytic enantioselective tandem carbonyl ylide formation-intramolecular 1,3-dipolar cycloaddition reactions of 2-diazo-3,6-diketoesters show promising scope in terms of asymmetric induction as the tethered alkene/alkyne dipolarophile component is varied. Cycloadditions were found to occur in moderate to very good yields, with a difference in ee exhibited by the electronically different 2-diazo-3,6-diketoesters 1, 25 and 33, 34. Values for ee of up to 90% for alkene dipolarophiles and up to 86% for alkyne dipolarophiles were obtained.
authors.affiliation: Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QY, UK. david.hodgson@chem.ox.ac.uk
authors.forename: David M
authors.initials: DM
authors.lastname: Hodgson
authors.forename: Agnès H
authors.initials: AH
authors.lastname: Labande
authors.forename: Françoise Y T M
authors.initials: FY
authors.lastname: Pierard
authors.forename: María A
authors.initials: MA
authors.lastname: Expósito Castro