[Principle of evidence-based medicine and its application in clinical trial practice for glutamine and gut permeability].
Evidence-based medicine (EBM) was developed from the progress of traditional clinical model trial patterns. EBM was based on well-designed, randomized, double blind, controlled, multiple center trails in order to assess end pont parameters, prognosis parameters (as: mortality, morbidity of complications and hospital stay etc.), quality of life and cost/effect ratio. It has been accepted in developed countries and could be the guidelines for Chinese clinical trials in the future. This article summarized the principle of EBM and attached with a clinical trial sample about effects of glutamine dipeptide on gut barrier function, post-operative complications and the hospital stay.
Jiang
Z
Z
Department of Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. jiangzm@cdm.imicams.ac.cn
Huang
Y
Y
Li
Z
Z
Li
D
D
Yu
K
K
D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D019317:Evidence-Based Medicine / Q000379:methods*; D005260:Female; D005973:Glutamine / Q000627:therapeutic use*; D006801:Humans; D007902:Length of Stay; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D010289:Parenteral Nutrition, Total / Q000379:methods*; D011183:Postoperative Complications / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
D005973:Glutamine