title: An intermediate in a new synthesis approach to beta-substituted beta-hydroxyaspartame.
abstract: The crystal and molecular structure of 1-tert-butyl 4-ethyl (2'R,3'R,5'R,2S,3S)-3-bromomethyl-3-hydroxy-2-[(2'-hydroxy-2',6',6'-trimethylbicyclo[3.1.1]hept-3'-ylidene)amino]succinate, C(21)H(34)BrNO(6), is presented. This compound is an intermediate in the new synthetic route to beta-substituted beta-hydroxyaspartates, which are blockers of glutamate transport.
authors.affiliation: Laboratoire des Aminoacides, Peptides et Protéines, Université Montpellier I et II, Faculté de Pharmacie, UMR CNRS 5810, 15 Avenue Charles Flahault, 34060 Montpellier Cedex 2, France.
authors.forename: Johny
authors.initials: J
authors.lastname: Wehbe
authors.forename: Valérie
authors.initials: V
authors.lastname: Rolland
authors.forename: Jean
authors.initials: J
authors.lastname: Martinez
authors.forename: Marc
authors.initials: M
authors.lastname: Rolland
mesh_terms: D001218:Aspartame / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: C484985:beta-hydroxyaspartame; D001218:Aspartame