Relationship between human lymphocyte antigen-B27 and clinical features of psoriatic arthritis.
Psoriatic arthritis is a chronic destructive joint disease. About 40% of psoriatic arthritis patients are positive for human lymphocyte antigens (HLA)-B27. This study investigated the relationship between HLA-B27 and clinical manifestations and prognosis in psoriatic arthritis patients. Demographic, clinical, and laboratory data were analyzed from 41 psoriatic arthritis patients with regular follow-ups. The mean percentage of HLA-B27 in psoriatic arthritis was about 39%. Positive HLA-B27 was associated with an increased risk of development of sacroillitis (relative risk 8.75; p<0.01) but not peripheral arthritis (p=0.925). Psoriatic arthritis patients with psoriatic nail disease (41.5% vs 2.4%, p<0.01) and distal interphalangeal joints involvement (26.8% vs 3.4%, p<0.05) had significantly increased risk of developing deformed joints. Psoriatic arthritis patients with positive HLA-B27 tend to develop deformed joints (p=0.068) as well as having elevated levels of C-reactive protein (p=0.072), although these results did not attain significance. HLA-B27 antigen may serve as a useful predictive marker for the development of sacroiliitis in Taiwan.
Tsai
Yi-Giien
YG
Department of Pediatrics, Christian Hospital, Changhua, ROC.
Chang
Deh-Ming
DM
Kuo
San-Yuan
SY
Wang
Wei-Ming
WM
Chen
Yi-Chueng
YC
Lai
Jenn-Haung
JH
D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000097:blood / Q000276:immunology* / Q000473:pathology; D001799:Blood Sedimentation; D002097:C-Reactive Protein; D005260:Female; D015796:HLA-B27 Antigen / Q000032:analysis*; D006801:Humans; D007596:Joints / Q000473:pathology; D008297:Male; D008875:Middle Aged
D015796:HLA-B27 Antigen; D002097:C-Reactive Protein