Angiostatin expression in ovarian cancer.
Angiostatin is a potent inhibitor of neovascularization, tumor growth and metastasis. We examined the expression of angiostatin and vascular endothelial growth factor (VEGF) through immunohistochemical analysis, along with microvessel density, in primary tumors obtained from 55 ovarian carcinoma patients. Angiostatin expression was not related to either stage of disease or histology. However, VEGF expression and microvessel density were related to stage of disease. Angiostatin expression did not correlate with VEGF expression. Microvessel density correlated with VEGF, but not angiostatin expression. Univariate analysis revealed that lack of angiostatin expression, VEGF expression, microvessel density and advanced stage of disease were significant risk factors for reduced survival. Multivariate analysis revealed that lack of angiostatin expression and advanced stage of disease were significant risk factors for reduced survival. Survival time was longer in patients with angiostatin-positive and VEGF-negative tumors than in patients with angiostatin-negative and VEGF-positive tumors. The presence of angiostatin expression and absence of VEGF expression are favorable prognostic factors with regard to survival in ovarian carcinoma patients.
Yabushita
Hiromitsu
H
Department of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Aichi 480-1195, Japan. yab@aichi-med-u-ac.jp
Noguchi
Mari
M
Obayashi
Yukihiko
Y
Kishida
Tameko
T
Noguchi
Yasuyuki
Y
Sawaguchi
Keizo
K
Noguchi
Masayoshi
M
D043168:Angiostatins / Q000096:biosynthesis* / Q000378:metabolism; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008833:Microcirculation; D015999:Multivariate Analysis; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000401:mortality; D011379:Prognosis; D012307:Risk Factors; D013997:Time Factors; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis / Q000378:metabolism
D042461:Vascular Endothelial Growth Factor A; D043168:Angiostatins