Patassium sensing oligonucleotide, PSO, based on DNA tetraplex formation.
Potassium Sensing Oligonucleotide, PSO, showing a high selectivity for K+ was synthesized by connecting 6-FAM and 6-TAMRA at the 5'- and 3'-termini of d(GGG TTA GGG TTA GGG TTA GGG), respectively. Circular dichroism (CD) spectra of PSO in the absence and presence of a various amount of KCl or NaCl revealed that PSO assumes an intramolecular or intermolecular antiparallel tetraplex structure in the presence of K+ and Na+, respectively.
Nojima
Takahiko
T
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
Ueyama
Hiroyuki
H
Takagi
Makoto
M
Takenaka
Shigeori
S
D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*; D011188:Potassium / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
D009841:Oligonucleotides; D004247:DNA; D011188:Potassium