Nuclear receptors: a rendezvous for chromatin remodeling factors.
Nuclear receptors (NRs) are a large family of ligand-induced transcription factors that include the vitamin D receptor. The recent discovery of WINAC, a novel ATP-dependent chromatin remodeling complex, has shed new light on the molecular mechanisms by which the vitamin D receptor controls gene expression with unexpected clinical implications.
Belandia
Borja
B
Institute of Reproductive and Developmental Biology, Imperial College London, Faculty of Medicine, Du Cane Road, London, W12 ONN, United Kingdom.
Parker
Malcolm G
MG
D002843:Chromatin / Q000378:metabolism*; D006801:Humans; D008957:Models, Genetic; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D014157:Transcription Factors; D014807:Vitamin D / Q000235:genetics / Q000378:metabolism; D018980:Williams Syndrome / Q000235:genetics
D002843:Chromatin; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D014807:Vitamin D