title: Haplotype blocks and linkage disequilibrium in the human genome.
abstract: There is great interest in the patterns and extent of linkage disequilibrium (LD) in humans and other species. Characterizing LD is of central importance for gene-mapping studies and can provide insights into the biology of recombination and human demographic history. Here, we review recent developments in this field, including the recently proposed 'haplotype-block' model of LD. We describe some of the recent data in detail and compare the observed patterns to those seen in simulations.
authors.affiliation: Department of Human Genetics, The University of Chicago, 920 East 58th Street, CLSC 507, Chicago, Illinois 60637, USA. jwall@genetics.bsd.uchicago.edu
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Wall
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Pritchard
mesh_terms: D002874:Chromosome Mapping; D015894:Genome, Human; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D011995:Recombination, Genetic