[Acute renal insufficiency secondary to interferon].
Alpha interferon is increasingly used in the treatment of malignancies and viral hepatitis. Renal involvement after its use consist in more cases on proteinuria. We report one case of acute renal failure without nephrotic syndrome but with tubulointerstitiel infiltration by mononuclear cells in 65 old man who had before interferon therapy 151 mumol/l of serum creatinine. Interferon was administrated for digestive carcinoid neoplasia and bone and liver metastasis. Outcome was improvement of renal function after withdrawn of interferon, dialysis and steroid treatment.
Laboudi
A
A
Service de néphrologie et de médecine interne, Hôpital Sud, Amiens.
Makdassi
R
R
Choukroun
G
G
Fournier
A
A
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary; D002276:Carcinoid Tumor / Q000188:drug therapy; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D007414:Intestinal Neoplasms / Q000188:drug therapy; D007421:Intestine, Small; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced; D011994:Recombinant Proteins
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins