[BRCA1 protein expression in sporadic breast and its clinical significance].
OBJECTIVE
To study BRCA1 gene expression in sporadic breast cancer in Han nationality and its relations to clinical pathological parameters.


METHODS
Immunohistochemical method was used to detect the BRCA1 protein in paraffin embedded breast cancer tissue of 51 patients. The relationship between BRCA1 protein and clinical pathological features was analysed.


RESULTS
BRCA1 protein was located in the nuclear of breast cancer cells. The rate of its down regulation of expression was 49.0% (25/51), which correlated reversely with c-erbB-2 protein, but did not correlate with histological grading, tumor size, lymph node involvement and patient age.


CONCLUSIONS
The detection of BRCA1 protein expression may be a reflection of its gene alteration. So it may be a primary method for screening the susceptibility to breast cancer.
Wang
Ben-zhong
BZ
Department of Surgery, First Affiliated Hospital, Anhui Medical University, Hefei 230022, China.
Wang
Jin
J
Wu
Qiang
Q
D000328:Adult; D000368:Aged; D019313:BRCA1 Protein / Q000032:analysis; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D019398:Genes, BRCA1; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged
D019313:BRCA1 Protein