title: Effect of soluble dietary fibre fraction of Trigonella foenum graecum on glycemic, insulinemic, lipidemic and platelet aggregation status of Type 2 diabetic model rats.
abstract: The soluble dietary fibre (SDF) fraction of Trigonella foenum graecum (Tf-sdf) has previously been shown to reduce postprandial elevation in blood glucose level of Type 2 model diabetic rats by delaying the digestion of sucrose. The Tf-sdf has now been investigated for its chronic effect on serum fructosamine, insulin and lipid levels, and on platelet aggregation in Type 2 diabetic rats. Tf-sdf was administered orally twice daily at a dose of 0.5 g kg(-1) for 28 days. It lowered the serum fructosamine level (P<0.05) with no significant change in the insulin level as compared with the control. Atherogenic lipids, i.e. triglycerides, cholesterol and LDL-cholesterol were found to decrease significantly in Tf-sdf fed rats (P<0.01). HDL-cholesterol showed an opposite trend (P=0.024), but serum non-esterified fatty acid (NEFA) values paralleled the atherogenic lipids (P=0.001). No significant effect on platelet aggregation (%) was found although there was a tendency to lower the aggregation (P=0.069). It is concluded that Tf-sdf has a beneficial effect on dyslipidemia and has a tendency to inhibit platelet aggregation in Type 2 model diabetic rats.
authors.affiliation: Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders, 1000 Dhaka, Bangladesh.
authors.forename: J M A
authors.initials: JM
authors.lastname: Hannan
authors.forename: B
authors.initials: B
authors.lastname: Rokeya
authors.forename: O
authors.initials: O
authors.lastname: Faruque
authors.forename: N
authors.initials: N
authors.lastname: Nahar
authors.forename: M
authors.initials: M
authors.lastname: Mosihuzzaman
authors.forename: A K
authors.initials: AK
authors.lastname: Azad Khan
authors.forename: L
authors.initials: L
authors.lastname: Ali
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004043:Dietary Fiber / Q000494:pharmacology* / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D019270:Fructosamine / Q000097:blood / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007194:India; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D020318:Rats, Long-Evans; D012639:Seeds; D013997:Time Factors; D029910:Trigonella
chemical_list: D004043:Dietary Fiber; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D010936:Plant Extracts; D019270:Fructosamine