title: [Intraperitoneal neoplastic dissemination of incidental gallbladder carcinoma after laparoscopic surgery].
abstract: BACKGROUND
  Several laboratory and clinical studies have raised the concern that laparoscopic procedures might worsen the prognosis of patient with malignant disease due to premature intraperitoneal cancer cell dissemination. The aim of the study was to examine the risk of the dissemination in patients with unsuspected gallbladder cancer diagnosed after laparoscopic cholecystectomy (LC).
  
  
  METHODS
  A retrospective clinicopathologic study was performed on 5 patients with unsuspected gallbladder cancer without preoperatively diagnosis among 1280 patients that underwent LC in the period 1993-2002. The possible neoplastic dissemination was compared to that reported in 8 patients affected from unsuspected gallbladder cancer diagnosed after open cholecystectomy.
  
  
  RESULTS
  Two patients with unsuspected gallbladder cancer (T1a-T2) presented a port-site recurrence after respectively six and four months. There was not statistically significant difference between types of cholecystectomy (LC or OC). Survival rate did not change according to whether the operation was carried out using LC or OC.
  
  
  CONCLUSIONS
  After an accurate checking of the factors indicated to explain the early neoplastic dissemination frequently observed in the patients undergone LC and an analysis of their own experience the Authors conclude that LC does not worsen the prognosis of unsuspected gallbladder cancer.
authors.affiliation: Cattedra di Chirurgia Generale, Università degli Studi, Messina.
authors.forename: E
authors.initials: E
authors.lastname: Cucinotta
authors.forename: C
authors.initials: C
authors.lastname: Lorenzini
authors.forename: S
authors.initials: S
authors.lastname: Lazzara
authors.forename: G
authors.initials: G
authors.lastname: Melita
authors.forename: P
authors.initials: P
authors.lastname: Melita
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D002763:Cholecystectomy; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects* / Q000295:instrumentation; D005260:Female; D005706:Gallbladder Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009366:Neoplasm Seeding; D010534:Peritoneal Neoplasms / Q000401:mortality / Q000556:secondary*; D011379:Prognosis; D012189:Retrospective Studies; D012306:Risk; D015996:Survival Rate