title: Quantitative studies of CD8+ T-cell responses during microbial infection.
abstract: MHC class I tetramer staining, intracellular cytokine staining and ELISPOT assays have made it possible to quantify CD8(+) T-cell responses precisely during and following viral and bacterial infection. Although these quantitative methods are by now familiar and trusted components of the immunologist's toolbox, their application to models of microbial infection continues to provide surprising insights into mammalian adaptive immunity. In the past year there have been many exciting new findings on CD8(+) T-cell priming, expansion and memory formation in response to microbial infection.
authors.affiliation: Infectious Diseases Service, Memorial Sloan-Kettering Cancer Center, Immunology Program, Sloan-Kettering Institute, New York 10021, USA. serbinan@mskcc.org
authors.forename: Natalya
authors.initials: N
authors.lastname: Serbina
authors.forename: Eric G
authors.initials: EG
authors.lastname: Pamer
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006678:HIV / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D007239:Infections / Q000276:immunology* / Q000382:microbiology*; D008213:Lymphocyte Activation
chemical_list: D016207:Cytokines