title: [Expression of Fas, FasL, and NF-kappa B in the process of osteoclast-like cell apoptosis effected by sodium fluoride].
abstract: OBJECTIVE
  To detect the changes in the expression of apoptosis signals: Fas, FasL and NF-kappa B in the process of osteoclast-like cell (OLC) apoptosis effected by sodium fluoride.
  
  
  METHODS
  After co-culture of osteoclast-like cells with 0, 5, 10 and 15 mg/L sodium fluoride, Fas, FasL and NF-kappa B antibody expressions were detected by immune-histochemistry.
  
  
  RESULTS
  The expression of Fas and FasL increased with the concentration of the sodium fluoride, however the expression of NF-kappa B decreased with the concentration of sodium fluoride.
  
  
  CONCLUSIONS
  In the process of OLC apoptosis induced by sodium fluoride, the expression of Fas and FasL increased, and that of NF-kappa B decreased with the concentration of sodium fluoride respectively, and the changes of the expression present a dose-dependent pattern.
authors.affiliation: Department of Radiobiology, Institute of Radiation Medicine, CAMS, PUMC, Tianjin 300192, China.
authors.forename: Yuan-ming
authors.initials: YM
authors.lastname: Sun
authors.forename: Fu-jun
authors.initials: FJ
authors.lastname: Yang
authors.forename: Yu-min
authors.initials: YM
authors.lastname: Li
authors.forename: Biao
authors.initials: B
authors.lastname: Lu
authors.forename: Mei
authors.initials: M
authors.lastname: Zhu
authors.forename: Ming-cai
authors.initials: MC
authors.lastname: Qiu
mesh_terms: D000818:Animals; D017209:Apoptosis; D053222:Fas Ligand Protein; D005260:Female; D005459:Fluorides / Q000494:pharmacology*; D008024:Ligands; D008562:Membrane Glycoproteins / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000378:metabolism*; D010010:Osteoclasts / Q000166:cytology* / Q000378:metabolism; D019014:fas Receptor / Q000378:metabolism*
chemical_list: D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D008024:Ligands; D008562:Membrane Glycoproteins; D016328:NF-kappa B; D019014:fas Receptor; D005459:Fluorides