title: Comparison of the response to ovarian stimulation between women with one ovary and those with two ovaries, in a program of ICSI/ET.
abstract: BACKGROUND
  Women with a single ovary form a group of special interest in assisted reproduction. The aim of this study was to compare the outcome of intracytoplasmic sperm injection cycles between women with one and two ovaries. To our knowledge, this is the first study reporting the outcome of intracytoplasmic sperm injection cycles with women with a single ovary.
  
  
  METHODS
  Sixty-three intracytoplasmic sperm injection cycles in 24 women with a single ovary were compared with 191 intracytoplasmic sperm injection cycles in 109 women with both ovaries. All cycles were stimulated with triptorelin-long protocol.
  
  
  RESULTS
  Statistically significant differences were found in the following parameters between women with a single ovary and women with two ovaries: total number of administrated gonadotropins (63.22 +/- 45.03 vs. 44.72 +/- 21.92), number of follicles (8.29 +/- 5.02 vs. 14.45 +/- 7.94), estradiol peak levels (1695.05 +/- 1177.34 vs. 2728.51 +/- 1852.67), number of retrieved metaphase II oocytes (6.95 +/- 3.78 vs. 11.72 +/- 6.11) and number of 2 PN oocytes (4.07 +/- 2.85 vs. 6.53 +/- 4.14). There were no differences in duration of stimulation, number of transferred embryos, and cumulative embryo score. In the group of women with a single ovary 14 pregnancies were achieved (22.2%), whereas 33 pregnancies were achieved in the group of women with two ovaries (17.28%).
  
  
  CONCLUSIONS
  Women with a single ovary have a decreased response to external ovarian stimulation than women with both ovaries, but they present a higher, although not statistically significant, pregnancy rate.
authors.affiliation: Department of Obstetrics/Gynecology, Medical University Lübeck, Lübeck, Germany. sf_alhasani@hotmail.com
authors.forename: Safaa
authors.initials: S
authors.lastname: Al-Hasani
authors.forename: Byron
authors.initials: B
authors.lastname: Asimakopoulos
authors.forename: Nikos
authors.initials: N
authors.lastname: Nikolettos
authors.forename: Klaus
authors.initials: K
authors.lastname: Diedrich
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005858:Germany; D006115:Greece; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009865:Oocytes; D010053:Ovary; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D017329:Triptorelin Pamoate / Q000008:administration & dosage
chemical_list: D017329:Triptorelin Pamoate; D004958:Estradiol