The role of hyperbaric oxygen in the management of subarachnoid hemorrhage.
OBJECTIVE
To determine the role of hyperoxic and hyperbaric therapy following experimental subarachnoid hemorrhage (SAH).


METHODS
Prospective, randomized, controlled animal study.


METHODS
Thirty male Wistar rats.


METHODS
Thirty rats were assessed for an initial neurologic status as double-blinded by two different neurosurgeons using a neurologic severity score (NSS) and then underwent an initial angiographic examination. Two days later, 0.3 ml of homologous blood was injected into the cisterna magna to produce a SAH-induced cerebral vasospasm. The NSS and angiographic examination were then repeated. The rats having no spasm or a spasm under 50% (n=8) and 50% or over 50% (n=22) were grouped separately, as groups 1 and 2, respectively. The rats having 50% or more spasm were further divided randomly into group 2A and 2B. The rats in groups 1 and 2A (n=11) underwent a 60-min course of 100% oxygen at the atmospheric pressure 1 atmosphere absolute (ata), and group 2B (n=11) received 100% oxygen at 3 ata for 1 h. Neurologic assessment was repeated on the next day and 7 days later.


RESULTS
The animals having no spasm or less than 50% spasm had a better NSS and outcome when compared with the animals having 50% or more spasm. But the animals with 50% or more spasm which underwent hyperbaric therapy were shown to have a better outcome compared to the animals having hyperoxic therapy.


CONCLUSIONS
Exposure to hyperbaric oxygen therapy seemed to accelerate the recovery of neurologic deficits secondary to experimental SAH.
Kocaoğullar
Yalçin
Y
Department of Neurosurgery, Selçuk University Medical School, Konya, Turkey. kyalcin34@hotmail.com
Ustün
M Erkan
ME
Avci
Emel
E
Karabacakoglu
Aydin
A
Fossett
Damirez
D
D000704:Analysis of Variance; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure; D002533:Cerebral Angiography; D016009:Chi-Square Distribution; D004195:Disease Models, Animal; D004311:Double-Blind Method; D006339:Heart Rate; D006931:Hyperbaric Oxygenation / Q000379:methods*; D008297:Male; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function; D012720:Severity of Illness Index; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D020301:Vasospasm, Intracranial / Q000209:etiology