title: [BRCA1 protein expression in sporadic breast and its clinical significance].
abstract: OBJECTIVE
  To study BRCA1 gene expression in sporadic breast cancer in Han nationality and its relations to clinical pathological parameters.
  
  
  METHODS
  Immunohistochemical method was used to detect the BRCA1 protein in paraffin embedded breast cancer tissue of 51 patients. The relationship between BRCA1 protein and clinical pathological features was analysed.
  
  
  RESULTS
  BRCA1 protein was located in the nuclear of breast cancer cells. The rate of its down regulation of expression was 49.0% (25/51), which correlated reversely with c-erbB-2 protein, but did not correlate with histological grading, tumor size, lymph node involvement and patient age.
  
  
  CONCLUSIONS
  The detection of BRCA1 protein expression may be a reflection of its gene alteration. So it may be a primary method for screening the susceptibility to breast cancer.
authors.affiliation: Department of Surgery, First Affiliated Hospital, Anhui Medical University, Hefei 230022, China.
authors.forename: Ben-zhong
authors.initials: BZ
authors.lastname: Wang
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D019313:BRCA1 Protein / Q000032:analysis; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D019398:Genes, BRCA1; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged
chemical_list: D019313:BRCA1 Protein