title: Prospective identification of risk factors for wound infection after lower extremity oncologic surgery.
abstract: BACKGROUND
  Surgical site infections (SSI) are frequent causes of morbidity and mortality after orthopaedic oncologic procedures. This study was conducted to identify the surgical site infection rate following a lower extremity or pelvic procedure and assess the risk factors for acquiring SSI by direct observation of orthopaedic oncology patients' wounds at a comprehensive cancer center.
  
  
  METHODS
  One hundred ten consecutive patients were prospectively studied. The surveillance of surgical site infections was carried out by a surgeon-trained nurse from the Infectious Disease Service. Nineteen variables were analyzed as risk factors.
  
  
  RESULTS
  The overall SSI rate was 13.6% (15 of 110). Excluding those patients with known preoperative infections, the SSI rate was 9.5% (10 of 105). Two statistically significant risk factors for surgical site infection in these patients emerged in the multivariate analysis: blood transfusion (P =.007) and obesity (P =.016). Procedure category was significant in univariate analysis only. Preoperative length of stay, length of procedure, prior adjuvant treatment (chemotherapy or radiotherapy), prior surgery, and use of an implant or allograft were not statistically significant risk factors for wound infection. Antibiotic usage patterns did not influence SSI rate.
  
  
  CONCLUSIONS
  Blood transfusion and obesity should be considered individual risk factors for the development of wound infection in patients having orthopaedic oncologic procedures.
authors.affiliation: Division of Orthopaedic Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
authors.forename: Carol D
authors.initials: CD
authors.lastname: Morris
authors.forename: Kent
authors.initials: K
authors.lastname: Sepkowitz
authors.forename: Claudette
authors.initials: C
authors.lastname: Fonshell
authors.forename: Neil
authors.initials: N
authors.lastname: Margetson
authors.forename: Janet
authors.initials: J
authors.lastname: Eagan
authors.forename: Jeremy
authors.initials: J
authors.lastname: Miransky
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Boland
authors.forename: John
authors.initials: J
authors.lastname: Healey
mesh_terms: D001803:Blood Transfusion; D001859:Bone Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors; D012983:Soft Tissue Neoplasms / Q000601:surgery*; D013530:Surgical Wound Infection / Q000453:epidemiology*