[Investigation on tumor-targeting characteristics of bifidobacterium infantis to melanoma in mice].
OBJECTIVE
To investigate the tumor-targeting of bifidobacterium infantis to melanoma.


METHODS
After bolus administration of bifidobacterium infantis with 3H-TdR tagged, the values of radioactivity in tumor and organs were examined at days 1, 2, 3, 4 and 7. Anaerobic culture and histological observation of tumor and normal organs were taken for the examination of tumor-targeting characteristics of bifidobacterium infantis.


RESULTS
The radioactivity in melanoma tissue increased progressively, while the radioactivity in normal organs became attenuated with time. The anaerobic culture showed an obvious proliferation of bifidobacterium infantis in tumor tissue. A large part of area was Gram positive in the tumor tissue section, whereas the normal tissue was Gram negative.


CONCLUSIONS
Bifidobacterium infantis has good tumor-targeting characteristics in mice melanoma.
Wu
Yu
Y
Department of Pathophysiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Yi
Cheng
C
Wang
Shuren
S
Zhang
Min
M
Zhang
Jing
J
D000818:Animals; D001644:Bifidobacterium / Q000254:growth & development / Q000502:physiology*; D005260:Female; D000922:Immunotoxins; D008545:Melanoma / Q000382:microbiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D019042:Muscle Neoplasms / Q000382:microbiology; D009368:Neoplasm Transplantation
D000922:Immunotoxins