[Serum lipofuscin level after renal transplantation].
BACKGROUND
Lipofuscin is believed to be the last product of lipid peroxidation. Elevated serum lipofuscin in chronic renal insufficiency and in multiple organ failure after major surgery has been detected.


OBJECTIVE
To compare serum lipofuscin level after renal transplantation with hemodialysed patients and healthy adults.


METHODS
Lipofuscin has been determined according to Tsuchida with Roumen's modification and expressed in arbitrary units (u.), in serum of 56 healthy adults, 11 renal transplant recipients and nine hemodialysed patients. Blood was collected before hemodialysis in uremic patients, or within 24 h after renal transplantation.


RESULTS
Serum lipofuscin in hemodialysed patients and renal recipients was significantly higher about 80% and 180% respectively, comparing to healthy adults.


CONCLUSIONS
Elevated serum lipofuscin levels after renal transplantations show high oxidative stress due to several mechanisms of lipid peroxidation in this group of patients.
Chmiel
Bogdan
B
I Katedy I Kliniki Chirurgii Ogólnej i Transplantacyjnej Slaskiej Akademii Medycznej w Katowicach. Chmiel@infomed.slam.katowice.pl
Kuśmierski
Stanisław
S
Kokocińska
Danuta
D
Cierpka
Lech
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000601:surgery* / Q000628:therapy; D016030:Kidney Transplantation; D008062:Lipofuscin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood; D018384:Oxidative Stress; D006435:Renal Dialysis; D013997:Time Factors
D015415:Biomarkers; D008062:Lipofuscin