title: Maternal serum and amniotic fluid hydroxyproline levels in neural tube defects.
abstract: OBJECTIVE
  The present study was aimed to evaluate the alterations of maternal serum and amniotic fluid OH- proline levels in neural tube defects (NTD).
  
  
  METHODS
  38 patients and 23 control subjects were selected from the patients followed up by the Departments of Genetics and Antenatal Care, Zekai Tahir Burak Women's Health, Education and Research Hospital. Amnion fluid and blood samples were synchronously obtained from NTD and control subjects. OH-proline levels were detected spectrophotometrically.
  
  
  RESULTS
  Amniotic fluid OH-proline levels were found to be increased in NTD patients compared to control subjects (p < 0.05). There was no statistically significant difference in serum OH-proline levels between the groups.
  
  
  CONCLUSIONS
  The results showed an increase in amniotic fluid OH-proline levels in NTD compared to the control group. It may be suggested that the increased OH-proline levels reflect increased collagen turnover in NTD patients. Indeed, amniotic fluid OH-proline levels may be a candidate as an additional diagnostic parameter in NTD.
authors.affiliation: Department of Biochemistry, Inönü University Medical Faculty, Malatya, Turkey. huseyinozyurt@hotmail.com
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Ozyurt
authors.forename: Aylin
authors.initials: A
authors.lastname: Totan
authors.forename: Semsettin
authors.initials: S
authors.lastname: Sahin
authors.forename: Cumhur
authors.initials: C
authors.lastname: Kilinç
authors.forename: Sadik
authors.initials: S
authors.lastname: Söğüt
authors.forename: Omer
authors.initials: O
authors.lastname: Akyol
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism*; D015415:Biomarkers; D003094:Collagen / Q000378:metabolism; D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D006909:Hydroxyproline / Q000097:blood*; D009436:Neural Tube Defects / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D003094:Collagen; D006909:Hydroxyproline