title: Fundamentals of transcription factors and their impact on pancreatic development and cancer.
abstract: Transcription factors are proteins that regulate gene expression by modulating the synthesis of messenger RNA. Since this process, known as gene transcription, is often the dominant control point in the production of many proteins, transcription factors are key regulators of numerous cellular functions, including secretion, proliferation, differentiation, and apoptosis. Most transcription factors are also the final effectors of signaling pathways that transduce signals from the cell membrane to the nucleus. Therefore alterations in the activity or expression of some transcription factors have a significant impact on the biology of human cells and may lead to the development of diseases. In this article we review this field of research with a particular emphasis on the role of transcription factors in pancreatic development and cancer.
authors.affiliation: Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Martin E
authors.initials: ME
authors.lastname: Fernandez-Zapico
authors.forename: Patricia S
authors.initials: PS
authors.lastname: Bramati
authors.forename: Shaheen
authors.initials: S
authors.lastname: Zakaria
authors.forename: Joanna A
authors.initials: JA
authors.lastname: Kaczynski
authors.forename: Raul
authors.initials: R
authors.lastname: Urrutia
mesh_terms: D000818:Animals; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology; D006801:Humans; D010179:Pancreas / Q000254:growth & development* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
chemical_list: D014157:Transcription Factors