title: 6-(Levulinyloxymethyl)-3-methoxy-2-nitrobenzoyl and 2-(levulinyloxymethyl)-5-methoxy-4-nitrobenzoyl groups as novel base-labile groups for 5'-hydroxy protection in solid-phase oligonucleotide synthesis.
abstract: The 6-(levulinyloxymethyl)-3-methoxy-2-nitrobenzoyl (LMMoNBz) and 2-(levulinyloxymethyl)-5-methoxy-4-nitrobenzoyl (LMMpNBz) groups were developed as novel base-labile groups for 5'-hydroxy protection in solid-phase oligonucleotide synthesis. A comparative study of the utility of LMMoNBz, LMMpNBz, and 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBz) groups is described.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan. kamaikek@ps.toyaku.ac.jp
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kamaike
authors.forename: Takashi
authors.initials: T
authors.lastname: Namiki
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kawashima
mesh_terms: D002851:Chromatography, High Pressure Liquid; D007982:Levulinic Acids / Q000737:chemistry*; D009578:Nitrobenzenes / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C482612:2-(levulinyloxymethyl)-5-methoxy-4-nitrobenzoyl; C482611:6-(levulinyloxymethyl)-3-methoxy-2-nitrobenzoyl; D007982:Levulinic Acids; D009578:Nitrobenzenes; D009841:Oligonucleotides