Role of MAP kinase in tumor progression and invasion.
Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that are essential for successful completion of metastasis. In this review, we discuss the potential role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and apoptosis.
Reddy
Kaladhar B
KB
Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA. kreddy@med.wayne.edu
Nabha
Sanaa M
SM
Atanaskova
Natasha
N
D017209:Apoptosis; D002465:Cell Movement; D018450:Disease Progression; D006801:Humans; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology*; D009389:Neovascularization, Pathologic; D015398:Signal Transduction