Variable-ionic strength kinetic experiments in drug stability studies.
The dependence of the pseudo-first-order rate constant on the ionic strength for the alkaline hydrolysis of indomethacin has been obtained, for the first time, in a single kinetic experiment carried out by varying with time the salt concentration inside the reaction vessel. The kinetic profile obtained was processed using as a mathematical model the variable-parameter kinetic equation containing the Bronsted-Bjerrum equation as the dependence function. The results are in good agreement with those obtained by the traditional method but the experimental time is reduced to about one-tenth.
Alibrandi
Giuseppe
G
Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica, Università di Messina, Salita Sperone 31, Vill S Agata, 98166 Messina, Italy. alibrandi@chem.unime.it
Coppolino
Salvatore
S
D'Aliberti
Santi
S
Ficarra
Paola
P
Micali
Norberto
N
Villari
Antonino
A
D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007213:Indomethacin / Q000493:pharmacokinetics*; D008956:Models, Chemical; D009994:Osmolar Concentration
D007213:Indomethacin