Does ACE inhibitor modify the morphofunctional state of the nephron?
Captopril, the inhibitor of the angiotensin convertase (ACE) was administered to white rats in two doses: 0.23 mg/day/rat and 0.71 mg/day/rat. The preparation was being applied for the period of 3 weeks. Observations were carried out in a transmission electron microscope. In the kidneys of the animals subjected to the experiment, in the cells of the proximal canaliculi dilution of the cytoplasm, numerous vacuoles in the apical and basal part of the cell, dilation of the intercellular space as well as more numerous lysosomes were observed. The above-described changes were more distinctly marked in animals which were given a higher dose of the drug. The studies in the electron microscope revealed morphofunctional changes of the nephron related to the application of the Captopril. Application of the Captopril may temporarily modulate the morphofunctional status of certain structures of the nephron, which was demonstrated in the foregoing experiment.
Kifer-Wysocka
Ewa
E
Department of Histology and Embryology, Medical University of Lublin.
Romanowska-Sarlej
Jadwiga
J
Matysiak
Włodzimierz
W
Milewska
Jolanta
J
Zakrzewski
Paweł
P
Czerny
Krystyna
K
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000633:toxicity*; D000818:Animals; D002216:Captopril / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008854:Microscopy, Electron; D015388:Organelles / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D014882:Water-Electrolyte Balance / Q000187:drug effects* / Q000502:physiology
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril