Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia.
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug.
Nahimana
Aimable
A
Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Rabodonirina
Meja
M
Helweg-Larsen
Jannik
J
Meneau
Isabelle
I
Francioli
Patrick
P
Bille
Jacques
J
Hauser
Philippe M
PM
D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology; D004271:DNA, Fungal / Q000032:analysis; D004094:Dihydropteroate Synthase / Q000235:genetics* / Q000378:metabolism; D025141:Drug Resistance, Fungal / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D011010:Pneumocystis / Q000187:drug effects / Q000235:genetics*; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy / Q000382:microbiology*; D012008:Recurrence; D013449:Sulfonamides / Q000494:pharmacology*; D013450:Sulfones / Q000494:pharmacology*
D000890:Anti-Infective Agents; D004271:DNA, Fungal; D013449:Sulfonamides; D013450:Sulfones; D004094:Dihydropteroate Synthase