title: Insulinomimetic zinc(II) complexes with natural products: in vitro evaluation and blood glucose lowering effect in KK-Ay mice with type 2 diabetes mellitus.
abstract: In vitro insulinomimetic activities of Zn(II) complexes with three natural products, betaine, L-lactic acid, and D-(-)-quinic acid (qui), were found in rat adipocytes treated with epinephrine in terms of the inhibition of free fatty acid release. Based on the results, the blood glucose lowering effect in KK-A(y) mice with type 2 diabetes mellitus was observed by daily i.p. injections of a monomeric zinc(II) complex, Zn(qui)(2), for 13 d.
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka City University, Osaka, Japan. kojima@sci.osaka-cu.ac.jp
authors.forename: Yoshitane
authors.initials: Y
authors.lastname: Kojima
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Eriko
authors.initials: E
authors.lastname: Ueda
authors.forename: Rie
authors.initials: R
authors.lastname: Ueda
authors.forename: Shuhei
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Katsumi
authors.initials: K
authors.lastname: Kumekawa
authors.forename: Naohisa
authors.initials: N
authors.lastname: Yanagihara
authors.forename: Hiromu
authors.initials: H
authors.lastname: Sakurai
mesh_terms: D000818:Animals; D001688:Biological Products / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007328:Insulin / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D051381:Rats; D017967:Zinc Compounds / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D001688:Biological Products; D001786:Blood Glucose; D007328:Insulin; D017967:Zinc Compounds