[Research progress on oxidative stress and apoptosis].
Many research findings revealed that oxidative stress may induce apoptosis. At present, the explanations for this phenomenon are: 1) ROS activated nuclear factor-KB and induction of the expression of nuclear factor-KB; 2) mitochondria-mediated cell apoptosis; 3) ROS mediated DNA damage and P53 activation; 4) ROS activated SAPK pathway to apoptosis. In this paper, the progress on oxidative stress and apoptosis was reviewed.
Chu
Qilong
Q
School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Yang
Kedi
K
Wang
Aiguo
A
D017209:Apoptosis / Q000502:physiology*; D004249:DNA Damage; D008928:Mitochondria / Q000502:physiology; D016328:NF-kappa B / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D016328:NF-kappa B; D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53