Implantation: can immunological parameters of implantation failure be of interest for pre-eclampsia?
We restate briefly why we consider that the Th1/Th2 paradigm, as useful as it has been, is now no longer adequate and is obsolete. We take as an example the role of IL-18, abortifacient at high doses but cardinal for the control of natural killer (NK) cell effects on spiral artery remodelling in mice, and likely also in humans. We then describe briefly our recent studies on cytokine defects and implantation failure in humans, a key feature being the link between uterine cytokine dysregulation and abnormal uterine vascular scores. We draw lessons for preeclampsia, and describe features of a model for its immune aetiology.
Chaouat
Gerard
G
U131 INSERM, Unite Cytokines dans la Relation Materno-Fetale, 32 Rue des Carnets, 92141 Clamart, France.
Ledee-bataille
Natalie
N
Zourbas
Sandrine
S
Dubanchet
Sylvie
S
Sandra
Olivier
O
Martal
Jacques
J
Ostojojic
Sasa
S
Frydman
René
R
D000818:Animals; D000911:Antibodies, Monoclonal; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism; D010064:Embryo Implantation / Q000276:immunology / Q000502:physiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015870:Gene Expression; D006801:Humans; D018664:Interleukin-12 / Q000096:biosynthesis / Q000276:immunology*; D020382:Interleukin-18 / Q000096:biosynthesis / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D020411:Oligonucleotide Array Sequence Analysis; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013194:Staining and Labeling; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014599:Uterus / Q000098:blood supply* / Q000276:immunology
D000911:Antibodies, Monoclonal; D016207:Cytokines; D020382:Interleukin-18; D018664:Interleukin-12