Phospholipase A(2).
Considerable progress has been made in characterizing the individual participant enzymes and their relative contributions in the generation of eicosanoids, lipid mediators derived from arachidonic acid, such as prostaglandins and leukotrienes. However, the role of individual phospholipase (PL) A(2) enzymes in providing arachidonic acid to the downstream enzymes for eicosanoid generation in biologic processes has not been fully elucidated. In this review, we will provide an overview of the classification of the families of PLA(2) enzymes, their putative mechanisms of action, and their role(s) in eicosanoid generation and inflammation.
Diaz
Bruno L
BL
Division of Cell Biology, National Cancer Institute-INCA, R André Cavalcanti 37, Centro, Rio de Janeiro 20231-050, Brazil. bldiaz@inca.gob.br
Arm
Jonathan P
JP
D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D001095:Arachidonic Acids / Q000096:biosynthesis / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology; D007249:Inflammation / Q000201:enzymology / Q000517:prevention & control; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000201:enzymology / Q000517:prevention & control; D010741:Phospholipases A / Q000145:classification / Q000378:metabolism / Q000502:physiology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism
D001095:Arachidonic Acids; D001094:Arachidonate 5-Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D010741:Phospholipases A