Sensitivity of immunocompetent cells of DBA/2 and C57Bl/6 mice to cyclophosphamide.
T cells were most sensitive to cyclophosphamide in DBA/2 mice, while in C57Bl/6 mice both T and B cells were sensitive. The formation of antibody-producing cells and the production of specific antibodies were delayed in DBA/2 mice immunized after pretreatment with antitumor drug. Accumulation of antibody-producing cells in the spleen was more active in immunized C57Bl/6 mice treated with cyclophosphamide compared to animals not treated with cyclophosphamide.
Masnaya
N V
NV
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk. ach@pharm.tsu.ru
Churin
A A
AA
Borsuk
O S
OS
Sherstoboev
E Yu
EY
D000818:Animals; D000938:Antigen-Presenting Cells / Q000187:drug effects; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000276:immunology; D003520:Cyclophosphamide / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects*
D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide