title: Fatal lactic acidosis and mimicking Guillain-Barré syndrome in an adolescent with human immunodeficiency virus infection.
abstract: We report a case of antiretroviral therapy-related fatal lactic acidosis occurring in a vertically infected HIV-positive 17-year-old patient. While receiving antiretroviral therapy with stavudine, didanosine, tenofovir and amprenavir, the patient developed severe acidosis and rapid neuromuscular and respiratory failure mimicking Guillain-Barré syndrome.
authors.affiliation: Department of Infectious Diseases, University of Genoa, School of Medicine, San Martino Hospital, Italy. raffaellarusso@hotmail.com
authors.forename: Rafaella
authors.initials: R
authors.lastname: Rosso
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Biagio
authors.forename: Antonio
authors.initials: A
authors.lastname: Ferrazin
authors.forename: Matteo
authors.initials: M
authors.lastname: Bassetti
authors.forename: Barbara Wenda
authors.initials: BW
authors.lastname: Ciravegna
authors.forename: Dante
authors.initials: D
authors.lastname: Bassetti
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives*; D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D002219:Carbamates; D003937:Diagnosis, Differential; D016049:Didanosine / Q000008:administration & dosage; D018450:Disease Progression; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D005663:Furans; D020275:Guillain-Barre Syndrome / Q000175:diagnosis*; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000635:transmission; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000009:adverse effects; D018570:Risk Assessment; D012720:Severity of Illness Index; D018119:Stavudine / Q000009:adverse effects; D013449:Sulfonamides / Q000009:adverse effects; D000068698:Tenofovir
chemical_list: D002219:Carbamates; D005663:Furans; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D013449:Sulfonamides; C095108:amprenavir; D000068698:Tenofovir; D018119:Stavudine; D000225:Adenine; D016049:Didanosine