[Transient dysfunction of the retinal ganglion cells after laser in situ keratomileusis].
OBJECTIVE
To evaluate the influence of high intraocular pressure(IOP) on the retinal ganglion cell function induced by suction during laser in situ keratomileusis(LASIK) using Frequency Doubling Technology(FDT).


METHODS
Twenty-seven eyes of 15 patients were studied. Threshold values of 19 targeted areas, mean deviation(MD), and pattern standard deviation (PSD) were measured before LASIK, and 2 hours, 1 day, and 1 week after LASIK. These parameters obtained by N-30 program of FDT were compared between before and after LASIK.


RESULTS
Significant decrease of MD and threshold value in all areas was recognized at 2 hours, but MD and threshold value in 6 of the 19 areas showed significant increase at 24 hours. Significant increase of PSD value at 2 hours was recognized. After 7 days, there were no significant differences in any parameters between before and after LASIK.


CONCLUSIONS
These results indicated that a transient dysfunction of the magnocellular pathway might be induced by high IOP during LASIK procedure.
Wang
Fan
F
Department of Ophthalmology, China-Japan Union Hospital, Ji Lin University, Japan.
Shoji
Nobuyuki
N
Shimizu
Kimiya
K
Kawai
Hiromi
H
Nagayama
Yuji
Y
Kubo
Yusuke
Y
Nagata
Sayaka
S
D000328:Adult; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D008297:Male; D008875:Middle Aged; D012165:Retinal Ganglion Cells / Q000502:physiology*