title: Photolysis of diacyl peroxides: a radical-based approach for the synthesis of functionalized amino acids.
abstract: [reaction: see text] Photolysis of the amino acid derived symmetrical and unsymmetrical diacyl peroxides at 254 nm at low temperature (-78 to -196 degrees C) generates various bis(amino acids) in a concise manner and with orthogonal protection. The methodology was applied to the synthesis of (4R)-5-propyl-L-leucine (PrLeu), a component of HUN-7293.
authors.affiliation: Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2.
authors.forename: M Daniel
authors.initials: MD
authors.lastname: Spantulescu
authors.forename: Rajendra P
authors.initials: RP
authors.lastname: Jain
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Derksen
authors.forename: John C
authors.initials: JC
authors.lastname: Vederas
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D010545:Peroxides / Q000737:chemistry*; D010782:Photolysis
chemical_list: D000596:Amino Acids; D010545:Peroxides