title: Association of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD.
abstract: Several studies have implicated the dopamine transporter gene (DAT1) as conferring susceptibility to attention deficit hyperactivity disorder (ADHD), in particular, a VNTR situated at the 3' end of the gene. In addition, the 10-repeat VNTR allele associated with ADHD has been reported to be associated with an over-active transporter protein (DAT). Thus children possessing this variant might be particularly responsive to methylphenidate, a drug known to act by blocking DAT. We have examined this hypothesis and now report an association between the 10-repeat VNTR DAT1 polymorphism and retrospectively rated methylphenidate response in a sample of 119 Irish children with ADHD (chi(2) = 7.918, df = 1, P = 0.005). Our findings suggest a role for the 10-repeat DAT1 risk allele in medication response and may help to predict positive clinical outcome in ADHD.
authors.affiliation: Departments of Psychiatry and Genetics, Trinity College Dublin, Dublin, Ireland. akirley@tcd.ie
authors.forename: Aiveen
authors.initials: A
authors.lastname: Kirley
authors.forename: Naomi
authors.initials: N
authors.lastname: Lowe
authors.forename: Ziarih
authors.initials: Z
authors.lastname: Hawi
authors.forename: Celine
authors.initials: C
authors.lastname: Mullins
authors.forename: Grainne
authors.initials: G
authors.lastname: Daly
authors.forename: Irwin
authors.initials: I
authors.lastname: Waldman
authors.forename: Mary
authors.initials: M
authors.lastname: McCarron
authors.forename: Deirdre
authors.initials: D
authors.lastname: O'Donnell
authors.forename: Michael
authors.initials: M
authors.lastname: Fitzgerald
authors.forename: Michael
authors.initials: M
authors.lastname: Gill
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000235:genetics*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002648:Child; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006801:Humans; D007494:Ireland; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000235:genetics*; D008774:Methylphenidate / Q000494:pharmacology*; D009419:Nerve Tissue Proteins
chemical_list: D000697:Central Nervous System Stimulants; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493214:SLC6A3 protein, human; D008774:Methylphenidate