title: Experience of minimally invasive treatment in 520 patients with intracranial aneurysms.
abstract: OBJECTIVE
  To summarize the experience of minimally invasive treatment in 520 patients with intracranial aneurysms on a retrospective study.
  
  
  METHODS
  The measures used in the treatment of 520 patients were reviewed in terms of timing of surgery, induced-hypotensive anesthesia, brain protection combined with temporal occlusion of the feeding artery, external drainage of CSF, dynamic monitoring of intracranial pressure, blood flow velocity, serum osmolality and CT scanning, anti-vasospasm therapy as well as selected interventional endovascular embolization of aneurysms.
  
  
  RESULTS
  Of the 520 patients, 485 were treated with either direct clipping or endovascular embolization and 35 patients were treated non-surgically. In 449 patients undergoing direct clipping and 36 undergoing endovascular embolization, intraoperative rupture of aneurysm occurred in 27 (6.0%) and 0%, respectively. Death occurred in 13 (2.6%), hemiplegia in 8 (1.6%), and vegetative state in 2 (0.4%). The operative mortality of direct clipping was 3.8% in 210 patients before 1990 and 1.8% in 275 patients after 1990 (36 patients undergoing endovascular embolization, the operative mortality was 0%).
  
  
  CONCLUSIONS
  The outcome of patients with intacranial aneurysms can be markedly improved and the operative mortality can be lowered by minimally invasive treatment.
authors.affiliation: Department of Neurosurgery, Xuan Wu Hospital, Capital University of Medical Sciences, Beijing 100053.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ding
authors.forename: Shenmao
authors.initials: S
authors.lastname: Li
authors.forename: An'an
authors.initials: A
authors.lastname: Duan
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Yu
authors.forename: Yang
authors.initials: Y
authors.lastname: Hua
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Wang
authors.forename: Jiakang
authors.initials: J
authors.lastname: Cao
authors.forename: Ruilin
authors.initials: R
authors.lastname: Zhao
authors.forename: Geng
authors.initials: G
authors.lastname: Xu
authors.forename: Chun
authors.initials: C
authors.lastname: Gu
authors.forename: Zhongpu
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured / Q000401:mortality / Q000628:therapy; D004621:Embolization, Therapeutic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000401:mortality / Q000601:surgery*; D007431:Intraoperative Complications / Q000401:mortality; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome