title: [Expression of chloride channel in nasal mucosa with allergic rhinitis].
abstract: OBJECTIVE
  To evaluate the role of chloride channel ClC-3 in perennial allergic rhinitis.
  
  
  METHODS
  The nasal mucosa from 19 patients with perennial allergic rhinitis were studied by immunohistochemistric staining and reverse transcriptase polymerase chain reaction (RT-PCR) for the expression of ClC-3.
  
  
  RESULTS
  ClC-3 was positively stained in 17 cases of 19 patients, with a rate of 89.6%. It mainly distributed in cytoplasm of epithelium and submucosal gland. All tissues displayed expected DNA length after PCR. The relative density of ClC-3 in mucosa with allergic rhinitis was 0.685 +/- 0.114 and 0.140 +/- 0.075 in normal.
  
  
  CONCLUSIONS
  ClC-3 played an important role in the over-secretion of liquor in allergic rhinitis.
authors.affiliation: Beijing Institute of Otolaryngology, Department of Otolaryngology Head and Neck Surgery, Tongren Hospital, Capital Medical University, Beijing, 100005, China. lhb7351@hotmail.com
authors.forename: Hua-bin
authors.initials: HB
authors.lastname: Li
authors.forename: De-min
authors.initials: DM
authors.lastname: Han
authors.forename: Bing
authors.initials: B
authors.lastname: Zhou
authors.forename: Xiang-dong
authors.initials: XD
authors.lastname: Wang
authors.forename: Zhong-yan
authors.initials: ZY
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D018118:Chloride Channels / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*
chemical_list: D018118:Chloride Channels; C115376:ClC-3 channel