title: Mosaic trisomy 2 in myelodysplastic syndromes and acute myeloblastic leukemias.
abstract: We present a short report here of two more patients with trisomy 2 as the sole chromosomal abnormality in a hematologic malignancy. Although trisomy 2 is a recognized abnormality in neoplasms, particularly hepatoblastomas, to the best of our knowledge only three other cases have been reported with trisomy 2, in patients with a hematologic malignancy. The two cases presented here of myelodysplastic syndrome transforming to acute myeloblastic leukemia and chronic myelomonocytic leukemia showed trisomy 2 as the sole abnormality.
authors.affiliation: Department of Cytogenetics, The Rayne Institute, King's College Hospital, London, UK. barbara.czepulkowski@kingsch.nhs.uk
authors.forename: B
authors.initials: B
authors.lastname: Czepulkowski
authors.forename: K
authors.initials: K
authors.lastname: Saunders
authors.forename: C
authors.initials: C
authors.lastname: Pocock
authors.forename: S
authors.initials: S
authors.lastname: Sadullah
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002889:Chromosomes, Human, Pair 2; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D009030:Mosaicism; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D014314:Trisomy