[Binucleated lymphocyte lymphocytosis].
We reported here a case of persistent polyclonal B-cell lymphocytosis (PPBL) in a 31-year-old female patient. Peripheral blood smears showed atypical binucleated lymphocytes which were polyclonal B-cells with kappa and lambda expression, and without clonal rearrangement of immunoglobulin heavy chain. Cytogenetic analysis found a trisomy 8, with premature chromosome condensation. Clinically, PPBL is associated with moderated splenomegaly, adenopathy, and smoking. It remains to be established whether PPBL is a real pathology or a simple cytological abnormality.
Vincenot-Blouin
A
A
Laboratoire d'hématologie, Centre hospitalier, 77100 Meaux. a-vincenot@ch-meaux.fr
Timbely
O
O
Abarah-Atassi
W
W
Mossafa
H
H
Allard
C
C
Michel
F
F
André-Kerneïs
E
E
D000328:Adult; D001402:B-Lymphocytes / Q000473:pathology; D002467:Cell Nucleus; D005260:Female; D006801:Humans; D008218:Lymphocytosis / Q000473:pathology*