Progressive multifocal leukoencephalopathy in a lung transplant recipient.
Progressive multifocal leukoencephalopathy (PML) is a sub-acute, demyelinating disease of the brain caused by a human polyomavirus. We describe a patient with the onset of PML 7 months after lung transplantation. The patient was treated with immunosuppressive modulation and cidofovir, a new anti-viral therapy for PML, with stabilization of the symptoms. We also review the 4 additional reports in the literature of PML after heart and lung transplantation. Progressive multifocal leukoencephalopathy may become more prevalent as the population of heart and lung transplantation recipients increases.
Shitrit
David
D
Pulmonary Institute, Rabin Medical Center, Sackler School of Medicine, Tel Aviv University, Petah Tivka, Israel.
Nirit
Lev
L
Shiran
Sheely I
SI
Izbicki
Gabriel
G
Sofer
Dov
D
Eldad
Melamed
M
Kramer
Mordechai R
MR
D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged