title: Frequency of stent thrombosis after acute coronary syndromes (from the SYMPHONY and 2nd SYMPHONY trials).
abstract: We studied stent thrombosis in 4,607 patients with acute coronary syndromes who received a coronary stent as part of routine care during 2 trials of aspirin versus sibrafiban for secondary prevention. In these patients, stent thrombosis occurred more often than in previous patients who underwent elective percutaneous coronary intervention. These patients and their outcomes may be more representative of patients with typical acute coronary syndromes undergoing stenting in clinical practice.
authors.affiliation: Duke Clinical Research Institute, Durham, North Carolina, USA.
authors.forename: Thaddeus R
authors.initials: TR
authors.lastname: Tolleson
authors.forename: L Kristin
authors.initials: LK
authors.lastname: Newby
authors.forename: Robert A
authors.initials: RA
authors.lastname: Harrington
authors.forename: Manjushri V
authors.initials: MV
authors.lastname: Bhapkar
authors.forename: Freek W A
authors.initials: FW
authors.lastname: Verheugt
authors.forename: Peter B
authors.initials: PB
authors.lastname: Berger
authors.forename: David J
authors.initials: DJ
authors.lastname: Moliterno
authors.forename: Harvey D
authors.initials: HD
authors.lastname: White
authors.forename: E Magnus
authors.initials: EM
authors.lastname: Ohman
authors.forename: Frans
authors.initials: F
authors.lastname: Van de Werf
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Topol
authors.forename: Robert M
authors.initials: RM
authors.lastname: Califf
mesh_terms: D000208:Acute Disease; D001241:Aspirin / Q000627:therapeutic use; D015984:Causality; D003327:Coronary Disease / Q000628:therapy*; D003328:Coronary Thrombosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000517:prevention & control; D010091:Oximes / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011183:Postoperative Complications / Q000453:epidemiology*; D015607:Stents / Q000009:adverse effects*; D013577:Syndrome
chemical_list: D010091:Oximes; D010880:Piperidines; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin; C100917:sibrafiban