title: New benzo[g]isoquinoline-5,10-diones and dihydrothieno [2,3-b]naphtho-4,9-dione derivatives: synthesis and biological evaluation as potential antitumoral agents.
abstract: Novel antitumoral agents with quinonic structure were synthesized and evaluated for their in vitro cytotoxic activities. This study examines the cytotoxic activities of several aryl benzo[g]isoquinoline-5,10-dione derivatives and a number of aminoacyl dihydrothieno[2,3-b]naphtho-4,9-dione (DTNQ) derivatives containing amino acids in position 3 of the ring system. Compound 6 showed remarkable cytotoxic activity at submicromolar concentration not only against several human leukaemia and solid tumour cell lines, but also toward sensitive and resistant human cell lines.
authors.affiliation: Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli Federico II, Naples, Italy.
authors.forename: Isabel
authors.initials: I
authors.lastname: Gomez-Monterrey
authors.forename: Pietro
authors.initials: P
authors.lastname: Campiglia
authors.forename: Paolo
authors.initials: P
authors.lastname: Grieco
authors.forename: Maria Vittoria
authors.initials: MV
authors.lastname: Diurno
authors.forename: Adele
authors.initials: A
authors.lastname: Bolognese
authors.forename: Paolo
authors.initials: P
authors.lastname: La Colla
authors.forename: Ettore
authors.initials: E
authors.lastname: Novellino
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity*; D044182:Benzylisoquinolines / Q000138:chemical synthesis* / Q000633:toxicity*; D045744:Cell Line, Tumor; D006801:Humans; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000633:toxicity*
chemical_list: D000596:Amino Acids; D000970:Antineoplastic Agents; D044182:Benzylisoquinolines; D009285:Naphthoquinones