5-lipoxygenase and FLAP.
The initial steps in the biosynthesis of leukotrienes from arachidonic acid are carried out by the enzyme 5-lipoxygenase (5-LO). In intact cells, the helper protein 5-LO activating protein (FLAP) is necessary for efficient enzyme utilization of endogenous substrate. The last decade has witnessed remarkable progress in our understanding of these two proteins. Here we review the molecular and cellular aspects of the expression, function, and regulation of 5-LO and FLAP.
Peters-Golden
M
M
Department of Internal Medicine, University of Michigan Health System, 1150 W Medical Center Drive, Ann Arbor, MI 48109-0642, USA. petersm@umich.edu
Brock
T G
TG
D058927:5-Lipoxygenase-Activating Proteins; D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D016718:Arachidonic Acid / Q000378:metabolism; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D020134:Catalytic Domain; D002451:Cell Compartmentation; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D015289:Leukotrienes / Q000096:biosynthesis; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
D058927:5-Lipoxygenase-Activating Proteins; D002352:Carrier Proteins; D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D008565:Membrane Proteins; D016718:Arachidonic Acid; D001094:Arachidonate 5-Lipoxygenase