title: Residue formation of fumonisin B1 in porcine tissues.
abstract: The residues derived from the uptake of fumonisin B1, a toxic metabolite of Fusarium verticillioides frequently occurring in corn and corn products, were determined in growing pigs. After oral administration of 100 mg FB(1)/animal/day for 5-11 days, serum, bile, lung, liver, kidney, brain, spleen, pancreas, heart, muscle, eye, and fat samples were collected immediately and analysed by LC-MS. The highest values were measured in kidney (833 +/- 1329 microg kg(-1), mean +/- SD), liver (231 +/- 163 microg kg(-1)), lung (170 +/- 311 microg kg(-1)) and spleen (854 +/- 2212 microg kg(-1)). Muscle contained 26 +/- 41 microg kg(-1), while in fat only 2 +/- 3 microg kg(-1) were traceable. Despite the potential accumulation over extended feeding periods as well as the large variations in the residue formation of FB(1), a carry-over in edible tissues from swine was considered not to be of toxicological relevance.
authors.affiliation: Technische Universität München, Institute of Animal Hygiene, Freising, Germany. Karsten.Meyer@wzm.tum.de
authors.forename: K
authors.initials: K
authors.lastname: Meyer
authors.forename: K
authors.initials: K
authors.lastname: Mohr
authors.forename: J
authors.initials: J
authors.lastname: Bauer
authors.forename: P
authors.initials: P
authors.lastname: Horn
authors.forename: M
authors.initials: M
authors.lastname: Kovács
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000284:Administration, Oral; D000821:Animal Feed / Q000009:adverse effects; D000818:Animals; D001826:Body Fluids / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D037341:Fumonisins / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008460:Meat / Q000009:adverse effects; D009132:Muscles / Q000378:metabolism; D009183:Mycotoxins / Q000494:pharmacology; D011634:Public Health; D013154:Spleen / Q000378:metabolism; D013552:Swine / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D037341:Fumonisins; D009183:Mycotoxins; C056933:fumonisin B1