title: Leptomeningeal metastases from recurrent squamous cell cancer of the skin.
abstract: We report two patients with leptomeningeal metastases from squamous cell cancer of the skin. In one patient cauda equina metastases appeared 6 years after initial presentation; the tumor from radical neck dissection demonstrated perineural invasion suggesting a possible route for subarachnoid dissemination. The other patient presented 2 years after initial diagnosis with confusion and cranial nerve seven and twelve palsies. Both patients died from complications of leptomeningeal metastases.
authors.affiliation: Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. begemanm@mskcc.org
authors.forename: Martin
authors.initials: M
authors.lastname: Begemann
authors.forename: Marc K
authors.initials: MK
authors.lastname: Rosenblum
authors.forename: John
authors.initials: J
authors.lastname: Loh
authors.forename: Dennis
authors.initials: D
authors.lastname: Kraus
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Raizer
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D002420:Cauda Equina / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000166:cytology; D017809:Fatal Outcome; D005682:Gadolinium; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000556:secondary*; D008875:Middle Aged; D037981:Neck Dissection; D010524:Peripheral Nervous System Neoplasms / Q000175:diagnosis / Q000473:pathology; D011379:Prognosis; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D005682:Gadolinium