title: Delineating the sites and progression of in vivo atrophy in multiple system atrophy using fluid-registered MRI.
abstract: We describe the pattern and progression of atrophy delineated using fluid registration of serial magnetic resonance imaging scans in a case of multiple system atrophy (MSA). The in vivo findings were consistent with those found at postmortem, including significant supratentorial atrophy concurrent with an unusual degree of cognitive impairment for MSA.
authors.affiliation: Dementia Research Group, Institute of Neurology, London, United Kingdom.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Schott
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Simon
authors.forename: Nick C
authors.initials: NC
authors.lastname: Fox
authors.forename: Andrew P
authors.initials: AP
authors.lastname: King
authors.forename: M Nadeem
authors.initials: MN
authors.lastname: Khan
authors.forename: Lisa
authors.initials: L
authors.lastname: Cipolotti
authors.forename: Dominic C
authors.initials: DC
authors.lastname: Paviour
authors.forename: John M
authors.initials: JM
authors.lastname: Stevens
authors.forename: Martin N
authors.initials: MN
authors.lastname: Rossor
mesh_terms: D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000150:complications / Q000473:pathology*; D009483:Neuropsychological Tests