[The analysis of S gene phylogenetic tree of HBV in transmission from father to infant].
OBJECTIVE
To study HBV transmission from father to infants, the study was carried out.


METHODS
The study contained 16 pairs of fathers who was HBV carriers, and infants whose mothers wasn't HBV carriers. The infants infected HBV in womb. The homogenous of HBV S gene were compared between fathers and infants, meanwhile HBV gene phylogenetic tree were analyzed.


RESULTS
The genotype of 16 pairs fathers and infants were HBV adw. The homogenous of HBV S gene were 98% approximately 100%. The mutation of 488, 491, 494, 530, 531, 546, 581, 621 nucleotide of HBV S gene caused in 112, 113, 114, 126, 131, 143, 156 amino acid substitution. The mutation of 126 amino acid from Threonine to Alanine didn't existed in the gene bank. The sequence was difference from gene classification.


CONCLUSIONS
The homogenous of HBV S gene of fathers and infants was very high. The HBV gene characteristic in China was difference from gene bank.
Wang
Shan-shan
SS
Military medical Institute, Guangzhou Command PLA, Guangzhou 510507, China.
Li
Wen-ling
WL
Peng
Gui-fu
GF
Li
Min-min
MM
Xiao
Hong
H
Jin
Hui-ling
HL
Zeng
Nian-hua
NH
Wang
Zhi-bin
ZB
Su
Jian-xin
JX
D000328:Adult; D002353:Carrier State / Q000635:transmission*; D006509:Hepatitis B / Q000635:transmission* / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D018812:Paternal Exposure; D010802:Phylogeny; D014759:Viral Envelope Proteins / Q000235:genetics*
C118669:S envelope protein, hepatitis B virus; D014759:Viral Envelope Proteins