The total synthesis and stereochemical revision of yanucamide A.
[reaction: see text] The first total synthesis of yanucamide A is reported via amide and ester couplings of the key components. This synthesis has established the configuration at the previously ambiguous 3-position, and also revised the stereochemistry at the 22-position, to give 3S,12S,17S,22S for the natural product.
Xu
Zhengshuang
Z
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
Peng
Yungui
Y
Ye
Tao
T
D047630:Depsipeptides; D009682:Magnetic Resonance Spectroscopy; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D047630:Depsipeptides; D010456:Peptides, Cyclic; C406625:yanucamide A