title: Cerebral networks linked to the event-related potential P300.
abstract: P300 is an event-related potential that is elicited by an oddball paradigm. In several neuropsychiatric diseases, differences in latencies and amplitude compared to healthy subjects have been reported. Because of its clinical significance, several investigations have tried to elucidate the intracranial origins of the P300 component. In the present study we could demonstrate a network of P300 generators. Investigated were 15 healthy subjects with an acoustical oddball paradigm within a fMRI block design, which enabled us to exclude attention or acoustical processing effects. The inferior and middle frontal, superior temporal, lower parietal cortex, the insula and the anterior cingulum were significantly activated symmetrical in both hemispheres.
authors.affiliation: Dept. of Psychiatric Neurophysiology, University Hospital of Clinical Psychiatry Bern, Bolligenstr. 111, Bern, Switzerland. horn@puk.unibe.ch
authors.forename: Helge
authors.initials: H
authors.lastname: Horn
authors.forename: Nadeem
authors.initials: N
authors.lastname: Syed
authors.forename: Heinrich
authors.initials: H
authors.lastname: Lanfermann
authors.forename: Konrad
authors.initials: K
authors.lastname: Maurer
authors.forename: Thomas
authors.initials: T
authors.lastname: Dierks
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D000704:Analysis of Variance; D001288:Attention; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology