title: T1a breast carcinoma and the role of axillary dissection.
abstract: OBJECTIVE
  Axillary dissection (AD) does not affect recurrence or survival in T1a breast cancer.
  
  
  METHODS
  Cohort study comparing patients who underwent AD and those who did not.
  
  
  METHODS
  Provincial cancer agency.
  
  
  METHODS
  Six hundred ninety-one women with pathologically diagnosed T1a tumors.
  
  
  METHODS
  Rates of axillary metastases stratified according to grade and lymphovascular and/or neural invasion, rates of relapse, and disease-specific survival.
  
  
  RESULTS
  Grade 1, 2, and 3 tumors without lymphovascular and/or neural invasion had axillary nodal involvement rates of 0.7%, 7%, and 7.8% of patients, respectively; with lymphovascular and/or neural invasion, axillary nodes were involved in 9.1%, 39.3%, and 44.4%, respectively. No statistically significant differences were found between the cohorts in relapse rates (P =.70) or survival (P =.84).
  
  
  CONCLUSIONS
  Higher tumor grade and lymphovascular and/or neural invasion increased the rate of nodal metastases in T1a tumors, but AD did not improve relapse rates or breast cancer-specific survival.
authors.affiliation: Department of Surgery, University of British Columbia, Vancouver.
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Schneidereit
authors.forename: Noelle
authors.initials: N
authors.lastname: Davis
authors.forename: Murray
authors.initials: M
authors.lastname: Mackinnon
authors.forename: Caroline H
authors.initials: CH
authors.lastname: Speers
authors.forename: Pauline T
authors.initials: PT
authors.lastname: Truong
authors.forename: Ivo A
authors.initials: IA
authors.lastname: Olivotto
mesh_terms: D001365:Axilla; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate