title: [Changes of plasma nitric oxide and tumor necrosis factor-alpha in lung elastase injury induced inflammatory response of hamster].
abstract: OBJECTIVE
  To investigate the role of the NO and TNF-alpha in lung elastase injury induced inflammatory response of hamster.
  
  
  METHODS
  Lung elastase injury induced inflammatory hamster model was established. NOS activity in airway epithelial cells and lung monocytes/macrophage, as well as the serum content of NO and TNF-alpha were measured respectively.
  
  
  RESULTS
  The results indicated that iNOS activity in epithelium and monocytes/macrophages were significantly enhanced. In the early period of inflammation the NO and TNF-alpha content in serum increased obviously and maintained in a high level (P < 0.001).
  
  
  CONCLUSIONS
  This Study suggested that both NO and TNF-alpha are important mediators participating in the lung elastase injury-induced inflammatory response. Our data suggested NO might play a regulatory role in the release of TNF-alpha.
authors.affiliation: Department of Physiology, Institute of Basic Medical Science, CAMS, PUMC, Beijing 100005, China. Lxyw315@ns.cetin.net.cn
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Cai
authors.forename: Q
authors.initials: Q
authors.lastname: Cai
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: S
authors.initials: S
authors.lastname: Su
mesh_terms: D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D008297:Male; D009569:Nitric Oxide / Q000097:blood* / Q000502:physiology; D010196:Pancreatic Elastase / Q000633:toxicity*; D011014:Pneumonia / Q000097:blood* / Q000139:chemically induced; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism* / Q000502:physiology
chemical_list: D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D010196:Pancreatic Elastase