title: Electrochemical monitoring of the interaction of doxorubicin with nicotinamide and Fe(III) ions under aerobic and anaerobic conditions.
abstract: The interaction of doxorubicin with Fe(III) ions and nicotinamide (NA) has been followed by square-wave voltammetry, cyclic voltammetry and UV-VIS. spectroscopy techniques at aerobic and anaerobic conditions. Fe(III)-doxorubicin complex gives a 1-electron reversible step at -0.494 V and a shoulder at 580 nm. Further, the Fe(III)-doxorubicin complex was found to be more stable at aerobic conditions. In the presence of NA, an intermediate (NA-Fe(III)-DQ) forms at -0.462 V under aerobic conditions. Because of the formation of this intermediate, nicotinamide may reduce the cardiotoxic effect of doxorubicin and cause to its detoxification.
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, Nineteen May University, 55139 Kurupelit, Samsun, Turkey. scakir@omu.edu.tr
authors.forename: S
authors.initials: S
authors.lastname: Cakir
authors.forename: E
authors.initials: E
authors.lastname: Biçer
authors.forename: E
authors.initials: E
authors.lastname: Coşkun
authors.forename: O
authors.initials: O
authors.lastname: Cakir
mesh_terms: D004317:Doxorubicin / Q000737:chemistry*; D004563:Electrochemistry; D007477:Ions / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D009536:Niacinamide / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D013053:Spectrophotometry; D013997:Time Factors
chemical_list: D007477:Ions; D009536:Niacinamide; D004317:Doxorubicin; D007501:Iron; D010100:Oxygen