title: Solution structure of the DNA complex with a quinacrine-netropsin hybrid molecule by NMR spectroscopy.
abstract: The solution structures of 1:1 complexes of a quinacrine-netropsin hybrid molecule with the self-complementary DNA duplexes, d(CGCGAATTCGCG)2 and d(CGAATTCG)2, have been studied by one- and two-dimensional 1H NMR spectroscopy. The NOE data indicate that the acridine ring of the hybrid intercalates into the 5'-GpA step and its netropsin moiety spans the minor groove of the central AATT region.
authors.affiliation: Department of Chemistry, Faculty of Science, Yamaguchi University, Yamaguchi 753-8512, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: S
authors.initials: S
authors.lastname: Tani
authors.forename: R
authors.initials: R
authors.lastname: Uchida
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry*; D015394:Molecular Structure; D009429:Netropsin / Q000031:analogs & derivatives* / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D011522:Protons; D011796:Quinacrine / Q000031:analogs & derivatives* / Q000737:chemistry; D012996:Solutions
chemical_list: D007364:Intercalating Agents; D009838:Oligodeoxyribonucleotides; D011522:Protons; D012996:Solutions; D009429:Netropsin; D004247:DNA; D011796:Quinacrine