title: First asymmetric total synthesis of Us-7 and -8, novel D-seco Corynanthe-type oxindole alkaloids from Uncaria attenuata: structure revision of Us-7 and determination of absolute stereochemistry.
abstract: [reaction: see text] Starting from (S)-glycidol, the asymmetric total synthesis of novel D-seco Corynanthe-type oxindoles Us-7 and Us-8 was accomplished. The structure of Us-7 was revised from the reported structure 1 with the (3R,7S) form to structure 22 with (3S,7R), and the absolute stereochemistry at C15 of both alkaloids was established.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Takayama
authors.forename: Rika
authors.initials: R
authors.lastname: Fujiwara
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Kasai
authors.forename: Mariko
authors.initials: M
authors.lastname: Kitajima
authors.forename: Norio
authors.initials: N
authors.lastname: Aimi