[Serum levels of interleukin-10 in patients with ovarian carcinoma in response to chemotherapy].
The levels of IL-10 and CA-125 were measured in 48 patients with ovarian carcinoma in different histological types and stages of clinical advance. The measurements were performed before surgical procedure and after chemotherapy. Pretreatment levels of IL-10 and CA-125 were significantly increased in carcinoma patients relatively to the control group. The frequency of higher levels and absolute value of IL-10 and CA-125 increased with the stage of disease. They decreased after chemotherapy in patients responding, while they remained elevated in non-responding to the treatment. The presents study shows, that IL-10 especially in the combination with CA-125 may be useful in the diagnosis and the monitoring of therapy results in patients with ovarian carcinoma.
Zakrzewska
Irena
I
Zakład Laboratoryjnej, Diagnostyki Klinicznej Akademii Medycznej 15-274 Białystok, ul. Waszyngtona 15 a.
Poznański
Janusz
J
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000276:immunology*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000276:immunology*; D013997:Time Factors; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D016753:Interleukin-10