Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease.
We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP-1) and CC chemokine receptor (CCR)-2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP-1 -2518A/G genotype affected the age-at-onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP-1 in PD.
Nishimura
Masataka
M
Department of Clinical Neuroscience, Tokushima University Hospital, Tokushima, Japan. mnishim@clin.tokushima-u.ac.jp
Kuno
Sadako
S
Mizuta
Ikuko
I
Ohta
Mitsuhiro
M
Maruyama
Hirofumi
H
Kaji
Ryuji
R
Kawakami
Hideshi
H
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D018932:Chemokine CCL2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
D018932:Chemokine CCL2