Cell polarity: the ups and downs of the Par6/aPKC complex.
A signaling complex in which atypical protein kinase C associates with a regulatory protein, Par6, plays an essential role in establishing cell polarity. Recent studies in organisms ranging from worms to mammals have highlighted some of the conserved mechanisms by which the assembly, localization and activity of this complex are regulated. Recent work is also beginning to unravel how this complex acts in concert with additional molecular complexes to establish and maintain polarity.
Henrique
Domingos
D
Instituto Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Portugal. henrique@fm.ul.pt
Schweisguth
François
F
D000818:Animals; D016764:Cell Polarity / Q000235:genetics*; D004848:Epithelium / Q000196:embryology; D019143:Evolution, Molecular; D011493:Protein Kinase C / Q000235:genetics* / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D018179:Receptors, Thrombin / Q000378:metabolism; D015398:Signal Transduction; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism
D011506:Proteins; D018179:Receptors, Thrombin; C105295:protease-activated receptor 3; C115015:PKC-3 protein; D011493:Protein Kinase C; D020764:cdc42 GTP-Binding Protein