Frequency of stent thrombosis after acute coronary syndromes (from the SYMPHONY and 2nd SYMPHONY trials).
We studied stent thrombosis in 4,607 patients with acute coronary syndromes who received a coronary stent as part of routine care during 2 trials of aspirin versus sibrafiban for secondary prevention. In these patients, stent thrombosis occurred more often than in previous patients who underwent elective percutaneous coronary intervention. These patients and their outcomes may be more representative of patients with typical acute coronary syndromes undergoing stenting in clinical practice.
Tolleson
Thaddeus R
TR
Duke Clinical Research Institute, Durham, North Carolina, USA.
Newby
L Kristin
LK
Harrington
Robert A
RA
Bhapkar
Manjushri V
MV
Verheugt
Freek W A
FW
Berger
Peter B
PB
Moliterno
David J
DJ
White
Harvey D
HD
Ohman
E Magnus
EM
Van de Werf
Frans
F
Topol
Eric J
EJ
Califf
Robert M
RM
D000208:Acute Disease; D001241:Aspirin / Q000627:therapeutic use; D015984:Causality; D003327:Coronary Disease / Q000628:therapy*; D003328:Coronary Thrombosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000517:prevention & control; D010091:Oximes / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011183:Postoperative Complications / Q000453:epidemiology*; D015607:Stents / Q000009:adverse effects*; D013577:Syndrome
D010091:Oximes; D010880:Piperidines; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin; C100917:sibrafiban