Chemo- and regio-selective modifications of nucleic acids by acetaldehyde and crotonaldehyde.
The reactions of guanine nucleosides and nucleotides with acetaldehyde or crotonaldehyde were significantly accelerated even under mild conditions by the presence of a basic amino acid such as arginine and lysine to form smoothly and selectively the corresponding cyclic 1,N2-propano adducts.
Sako
Magoichi
M
Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan.
Yaekura
Isamu
I
Deyashiki
Yoshihiro
Y
D000079:Acetaldehyde / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D009696:Nucleic Acids / Q000737:chemistry*
D000447:Aldehydes; D009696:Nucleic Acids; C012796:2-butenal; D000079:Acetaldehyde