Retinoprotective effect of Epithalon in campbell rats of various ages.
We studied the retinoprotective effect of Epithalon administered to the offspring of Campbell rats during postnatal ontogeny and to mothers before mating and during pregnancy. After this treatment the morphological structure and functional activity of the retina were preserved for a longer period compared to control rats (by 2 times) and to the animals receiving the peptide only during postnatal ontogeny (by 30%).
Khavinson
V Kh
VKh
St Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences.
Razumovsky
M I
MI
Trofimova
S V
SV
Razumovskaya
A M
AM
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001284:Atrophy; D015785:Eye Diseases, Hereditary / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006801:Humans; D009842:Oligopeptides / Q000627:therapeutic use*; D010857:Pigment Epithelium of Eye / Q000033:anatomy & histology / Q000378:metabolism / Q000473:pathology*; D011247:Pregnancy; D051381:Rats; D012162:Retinal Degeneration / Q000188:drug therapy* / Q000473:pathology*
D009842:Oligopeptides; C421253:alanyl-glutamyl-aspartyl-glycine