The Ti plasmid of Agrobacterium tumefaciens harbors an attM-paralogous gene, aiiB, also encoding N-Acyl homoserine lactonase activity.
The Agrobacterium tumefaciens C58 genome contains three putative N-acyl homoserine lactone (acyl-HSL) hydrolases, which are closely related to the lactonase AiiA of Bacillus. When expressed in Escherichia coli, two of the putative acyl-HSL hydrolases, AttM and AiiB, conferred the ability to degrade acyl-HSLs on the host. In Erwinia strain 6276, the lactonases reduced the endogenous acyl-HSL level and the bacterial virulence in planta.
Carlier
A
A
Institut des Sciences du Végétal, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.
Uroz
S
S
Smadja
B
B
Fray
R
R
Latour
X
X
Dessaux
Y
Y
Faure
D
D
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000378:metabolism; D016960:Agrobacterium tumefaciens / Q000201:enzymology / Q000235:genetics*; D000595:Amino Acid Sequence; D002265:Carboxylic Ester Hydrolases / Q000235:genetics*; D006867:Hydrolases / Q000235:genetics; D008969:Molecular Sequence Data; D036741:Plant Tumor-Inducing Plasmids
C088386:homoserine lactone; D006867:Hydrolases; D002265:Carboxylic Ester Hydrolases; C432003:N-acyl homoserine lactonase; D015107:4-Butyrolactone