Airway responsiveness of rabbits after exposure to 2-octyl dodecanol.
Cooling lubricants are used in the metal industry during drilling or turning. Vapors and aerosols of these lubricants are suspected to induce airway hyperresponsiveness (AHR) in exposed workers. In a previous study the authors demonstrated that water-soluble lubricants induce AHR after acute exposure of rabbits to concentrations near the German MAK value (10 mg/m(3)). In the present investigation the influence of a fatty alcohol as special non-water-soluble cooling lubricant was examined to determine its influence on airway responsiveness (AR). The effects of an aerosolized non-water-soluble lubricant (40, 90, and 220 mg/m(3)) on AR to acetylcholine in a rabbit model were studied. Lubricant atmosphere analysis was performed with infrared spectroscopy. Before exposure, after 2 and 4 hours of application, AR to aerosols from 0.2 and 2% acetylcholine was tested. Basal airway and cardiovascular parameters as well as blood gases did not change during exposure. Lubricant aerosol concentration of 40 and 220 mg/m(3) for 4 hours did not significantly alter AR. Inhalation of 90 mg/m(3) lubricant increased contractile response to ACH significantly. In contrast to formerly investigated water-soluble cooling lubricants, the examined non-water-soluble lubricant did not increase AR in concentrations near the MAK; however, in higher concentrations a significant (p<.05) increase was obtained.
Mensing
Thomas
T
Research Institute for Occupational Medicine of the Institutions for Statutory Accident Insurance and Prevention (BGFA), Institute of the Ruhr University, Bürkle-de-la-Camp-Platz 1, D-44789 Bochum, Germany. mensing@bgfa.ruhr-uni-bochum.de
Fricke
Hajo-H
HH
Marek
Wolfgang
W
Voss
Bruno
B
Brüning
Thomas
T
Wilhelm
Michael
M
D000109:Acetylcholine / Q000008:administration & dosage; D000336:Aerosols; D000403:Airway Resistance; D000818:Animals; D001985:Bronchial Provocation Tests / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D005233:Fatty Alcohols / Q000633:toxicity*; D019570:Inhalation Exposure; D011817:Rabbits; D012119:Respiration / Q000187:drug effects*
D000336:Aerosols; D005233:Fatty Alcohols; C456972:octyl dodecanol; D000109:Acetylcholine