title: The influence of nonsteroidal anti-inflammatory drugs abuse and chronic stress on the development of necrotizing fasciitis--case report.
abstract: In this report we present the case of a 19-year-old woman who was admitted to hospital due to an intense pain of the left gluteofemoral region and the symptoms of toxic shock. For 5 days before admission to hospital the patient had a strong pain and fever, up to 40 degrees C, treated with high doses of nonsteroidal anti-inflammatory drugs administered by oral and intramuscular routes. During the next 20 hours a large oedema of the left femoral region developed, the skin became purplish, and bullae filled with the hemorrhagic fluid appeared. On the group of typical skin changes, results of computed tomography and findings during surgical treatment necrotizing fasciitis was recognized. The patient was transferred by plane to the National Center of Hyperbaric Medicine Institute of Sea and Tropical Medicine where she was successfully treated with hyperbaric oxygen therapy. In this paper we discuss the problem of the association between the use of nonsteroidal anti-inflammatory drugs, chronic stress and the development of necrotizing fasciitis.
authors.affiliation: Department of Internal Medicine, Department of Dermatology and Venereology, Department of Radiology, Medical University of Lublin.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Myśliński
authors.forename: Jerzy
authors.initials: J
authors.lastname: Mosiewicz
authors.forename: Maria
authors.initials: M
authors.lastname: Kazubek
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Przyszlak-Szabała
authors.forename: Witold
authors.initials: W
authors.lastname: Krupski
authors.forename: Ewelina
authors.initials: E
authors.lastname: Pegiel-Sićko
authors.forename: Janusz
authors.initials: J
authors.lastname: Hanzlik
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002908:Chronic Disease; D019115:Fasciitis, Necrotizing / Q000209:etiology* / Q000628:therapy*; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D007869:Leg Injuries / Q000209:etiology / Q000628:therapy; D012772:Shock, Septic / Q000209:etiology* / Q000628:therapy; D013312:Stress, Physiological / Q000150:complications*; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal