[Relationship of changes in sleep architecture and cognitive function in patients with obstructive sleep apnea syndrome].
OBJECTIVE
To explore the relationship between sleep architecture changes and cognitive impairment in patients with obstructive sleep apnea syndrome (OSAS).


METHODS
Thirty-six patients with OSAS and 18 controls were administered polysomnography and neuropsychological tests of visual regeneration, digital symbol, comprehensive memory and digital span.


RESULTS
Performances on the visual regeneration test and digital symbol test in patients with OSAS were impaired significantly compared with the control group (P < 0.01). Patients' performance on the visual regeneration test was significantly associated with slow wave sleep duration (r = 0.423, P < 0.05) and that on the digital symbol test was significantly associated with REM sleep duration (r = 0.378, P < 0.05).


CONCLUSIONS
Slow wave sleep and REM sleep derivation may play a role in the cognitive impairment in patients with OSAS.
Xu
Yan
Y
Department of Neurology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China. xuyan6246@sina.com
Li
Shun-wei
SW
Huang
Xi-zhen
XZ
Cong
Bo
B
D000328:Adult; D003072:Cognition Disorders / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D020187:REM Sleep Behavior Disorder / Q000209:etiology; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000523:psychology*; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM