title: Mutation of the photoreceptor specific homeodomain gene Pph13 results in defects in phototransduction and rhabdomere morphogenesis.
abstract: The expression and organization of the phototransduction signaling proteins into a specialized light-sensing organelle, the rhabdomere, is required for photoreceptor cells to detect light. We report the characterization of the mutant Pph13(hazy). Pph13 is a homeodomain transcription factor expressed only in photoreceptor cells. Pph13 expression correlates with the differentiation and not specification of photoreceptor cells. In agreement with its expression profile, we find Pph13 is required for both rhabdomere morphogenesis and for the proper detection of light. In addition, we demonstrate that Pph13 exerts its effect by the regulation of photoreceptor specific gene expression.
authors.affiliation: Division of Biology, University of California San Diego, La Jolla, CA 92093, USA. azelhof@biomail.ucsd.edu.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Zelhof
authors.forename: Edmund
authors.initials: E
authors.lastname: Koundakjian
authors.forename: Audra L
authors.initials: AL
authors.lastname: Scully
authors.forename: Robert W
authors.initials: RW
authors.lastname: Hardy
authors.forename: Linda
authors.initials: L
authors.lastname: Pounds
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage; D004330:Drosophila / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000196:embryology* / Q000235:genetics; D005136:Eye Proteins / Q000235:genetics / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D008027:Light; D009024:Morphogenesis; D009154:Mutation; D017956:Photoreceptor Cells, Invertebrate / Q000033:anatomy & histology / Q000473:pathology / Q000502:physiology; D014158:Transcription, Genetic; D014785:Vision, Ocular / Q000502:physiology*
chemical_list: D029721:Drosophila Proteins; D005136:Eye Proteins; D018398:Homeodomain Proteins; C411858:Pph13 protein, Drosophila