A short synthesis of antimalarial peroxides.
A concise and efficient synthesis of two simplified diastereomeric analogues of a natural peroxide is presented. Both compounds could be isolated in high purity and fully identified. They exhibited moderate antimalarial activity.
Cointeaux
L
L
UPRES A 8076 BioCIS, Faculté de Pharmacie, rue J.-B. Clément, F-92296, Châtenay Malabry, France.
Berrien
J-F
JF
Mahuteau
J
J
Huu-Dâu
M E Trân
ME
Cicéron
L
L
Danis
M
M
Mayrargue
J
J
D000962:Antimalarials / Q000138:chemical synthesis* / Q000302:isolation & purification; D010545:Peroxides / Q000138:chemical synthesis* / Q000302:isolation & purification; D013237:Stereoisomerism
D000962:Antimalarials; D010545:Peroxides