title: [Study on the genic polymorphism of HLA-DRB1 in a population in the north of China].
abstract: OBJECTIVE
  To investigate at the DNA level the polymorphism of HLA-DRB1 gene in Han population in Beijing of China.
  
  
  METHODS
  This study was conducted in the Hans in Beijing. A total of 2810 normal and unrelated neonates were analyzed and subjected to HLA-DRB1 low resolution typing, and from among them 217 neonates were randomly selected for DRB1 high resolution typing by polymerase chain reaction-sequence specific primers technique.
  
  
  RESULTS
  Fourteen HLA-DRB1 specificity and 39 alleles were found with HLA-DRB1 *09012, *1501, *07011, *08032 as the most common genes. Their gene frequencies and allelic distributions were compared to those observed in other ethnic populations.
  
  
  CONCLUSIONS
  The results showed the characteristic of HLA-DRB1 distribution, and provided more comprehensive and accurate gene data that may serve as normal reference values for the population in Beijing, China.
authors.affiliation: HLA Laboratory, People's Hospital and Institute of Hematology, Beijing University, Beijing, 100044 PR China. lee-adan@Yahoo.com.cn
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Xi
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553509:HLA-DRB1*09:01:02 antigen