Qualitative assessment of selective blockade of M(4)-cholinoreceptors in the whole organism.
Quantitative assessment of selective blockade of M4-subtype muscarinic receptors was performed by the number of pilocarpine-induced movements of lower jaw in rats. Three antagonists (atropine, cyclodol, and glipin) were used in the experiments. Glipin produced the most potent blockade of M4 receptors in the whole organism compared to other test antagonist.
Dagaev
S G
SG
Institute of Toxicology, Ministry of Health of the Russian Federation, St Petersburg.
Kosmachev
A B
AB
Libman
N M
NM
Kubarskaya
L G
LG
Khrabrova
A V
AV
Sanotskii
V I
VI
Fil'ko
O A
OA
Dolgo-Saburov
V B
VB
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D009043:Motor Activity / Q000187:drug effects*; D018721:Muscarinic Agonists / Q000494:pharmacology; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D043588:Receptor, Muscarinic M4 / Q000378:metabolism*; D014282:Trihexyphenidyl / Q000494:pharmacology; D014326:Tropanes / Q000494:pharmacology
D018721:Muscarinic Agonists; D018727:Muscarinic Antagonists; D043588:Receptor, Muscarinic M4; D014326:Tropanes; D010862:Pilocarpine; C026280:glipin; D014282:Trihexyphenidyl; D001285:Atropine