Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy.
The ATP-binding cassette (ABC) transporters belong to the largest known transporter gene family and translocate a variety of substrates including chemotherapy agents. ABC multidrug transporter expression has been implicated in tumor cell resistance to anticancer therapy, altered disposition of chemotherapy drugs, and associated chemotherapy toxicity. More recently, genetic heterogeneity has been described in a number of the ABC transporter genes, including ABC transporters that contribute to the pharmacokinetics and/or pharmacodynamics of chemotherapy drugs. The role of these transporters and their naturally occurring genetic polymorphisms in cancer and chemotherapy is reviewed.
Lockhart
A Craig
AC
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Tirona
Rommel G
RG
Kim
Richard B
RB
D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D004358:Drug Therapy; D015870:Gene Expression / Q000187:drug effects / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D010597:Pharmacogenetics / Q000639:trends*
D018528:ATP-Binding Cassette Transporters