Design and synthesis of curcumin-bioconjugates to improve systemic delivery.
Di-O-glycinoyl curcumin (I), di-O-glycinoyl-C4-glycyl-curcumin (II), 5'-deoxy-5'-curcuminyl thymidine (5'-cur-T) (III) and 2'-deoxy-2'-curcuminyl uridine (2'-cur-U) (IV) have been synthesized and characeterised by elemental analysis & 1H NMR. The antibacterial activities of these four bioconjugates has been tested particularly for multiresistant micro-organisms. Best results are shown by I & IV. These bioconjugates serve dual purpose of systemic delivery as well as therapeutic agents against viral diseases.
Kumar
S
S
Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211 002, India.
Dubey
K K
KK
Tripathi
S
S
Fujii
M
M
Misra
K
K
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology; D003474:Curcumin / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D016503:Drug Delivery Systems; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D013936:Thymidine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000138:chemical synthesis; D014529:Uridine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000138:chemical synthesis
D000890:Anti-Infective Agents; D003474:Curcumin; D013936:Thymidine; D014529:Uridine