Protein-deficient diet in pregnant females impairs functional activity of enzyme systems in digestive and non-digestive organs in the offspring.
Activity of disaccharidases in various portions of the small intestine markedly increased in 6-month-old offspring of pregnant females feeding a protein-deficient diet. Activities of amino- and dipeptidases decreased in the kidneys, while alkaline phosphatase activity remained practically unchanged. Probably, information about protein restriction in nutrition of pregnant females is stored in the biochemical memory of adult offspring and promotes the development of metabolic disturbances.
Timofeeva
N M
NM
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. nmtimof@pavlov.infran.ru
Gordova
L A
LA
Egorova
V V
VV
Nikitina
A A
AA
D000367:Age Factors; D000626:Aminopeptidases / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D018753:Diet, Protein-Restricted; D004186:Disaccharidases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007422:Intestines / Q000201:enzymology*; D007668:Kidney / Q000201:enzymology*; D008099:Liver / Q000201:enzymology; D008297:Male; D009747:Nutritional Physiological Phenomena; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D004186:Disaccharidases; D000626:Aminopeptidases