title: Foxy, a designer tryptamine hallucinogen.
abstract: Foxy is slang for 5-methoxy-N,N-diisopropyltryptamine. It has hallucinogenic properties, similar to other tryptamine compounds, and is mildly euphoric. This case report describes a 21-year-old Caucasian man who ingested a pill called Foxy containing an unknown amount of drug. He was observed in hospital for 2 h, during which time he had mild hallucinations and could not move his limbs. A urine sample was collected approximately 4 h after drug ingestion. The patient was then discharged with no follow up assessment. The 5-methoxy-N,N-diisopropyltryptamine was identified in the urine by gas chromatography-mass spectrometry. Standards prepared from the pure material were used in the identification. Quantitative analysis using the same analytical technique resulted in a urinary concentration of 1.7 micro g/mL. Through oxidative deamination, the metabolite, 5-methoxy-indole acetic acid, was formed. It was identified in the urine, and the concentration was determined to be 1.3 micro g/mL using gas chromatography-mass spectrometry. Two other compounds were discovered in the urine sample as a result of a routine drug screen. From their mass spectra, they were tentatively identified as 5-methoxy-N-isopropyltryptamine and 5-methoxy-N,N-diisopropyltryptamine-N'-oxide.
authors.affiliation: Laboratory Medicine, St. Boniface General Hospital, Winnipeg, Manitoba, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Meatherall
authors.forename: Pankaj
authors.initials: P
authors.lastname: Sharma
mesh_terms: D008735:5-Methoxytryptamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine*; D000284:Administration, Oral; D000328:Adult; D003497:Cyclic N-Oxides / Q000652:urine; D015198:Designer Drugs; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006213:Hallucinogens / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000031:analogs & derivatives* / Q000652:urine; D008297:Male; D012680:Sensitivity and Specificity; D013607:Tablets; D013997:Time Factors
chemical_list: C487455:5-methoxy-N,N-diisopropyltryptamine N-oxide; C487454:5-methoxy-N-isopropyltryptamine; D003497:Cyclic N-Oxides; D015198:Designer Drugs; D006213:Hallucinogens; D013607:Tablets; C033696:5-methoxy-N,N-diisopropyltryptamine; C001736:5-methoxyindoleacetic acid; D008735:5-Methoxytryptamine; D006897:Hydroxyindoleacetic Acid