Tumour's angiogenesis--the function of VEGF and bFGF in colorectal cancer.
The main objective of this paper was to present the view on the vascular endothelial growth factor (VEGF) and basis fibroblast growth factor (bFGF) in the angiogenesis in the colorectal career. The analysis includes the works of these scientists, who proved the relationship between VEGF and bFGF expression and the advancement level of colorectal cancer and the survival of the patients ill with this disease. It was stated that the highest levels of these factors were connected with the advancement of neoplastic process, especially when metastases coexisted at the same time. It was also proved that the higher levels of VEGF and bFGF gave worse prognosis as far as survival was concerned. Apart from this, other factors effecting angiogenesis and inhibiting factors were also presented.
Kos
Marek
M
2nd Department of General Surgery, Medical University of Lublin.
Dabrowski
Andrzej
A
D015179:Colorectal Neoplasms / Q000098:blood supply* / Q000378:metabolism* / Q000503:physiopathology; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2