[Ototoxicity of gentamicin assessed by the vestibular evoked potentials].
OBJECTIVE
To assess ototoxicity of gentamicin by the vestibular evoked potentials (VsEPs) and auditory brainstem response (ABR).


METHODS
40 guinea pigs were divided randomly into 4 groups, 10 animals of group A were injected gentamicin intramuscularly 60 mg/(kg.d). 10 of group B were injected Ns intramuscularly 0.5 ml/d as control. 10 of group C were given gentamicin intratympanic 5 mg/d(0.1 ml). 10 of group D were given Ns intratympanic 0.1 ml/d as control. ABR and VsEPs were measured prior to and following the administration.


RESULTS
After treatment group A 21 days, 40 days, group C 5 days, 10 days, ABR and VsEPs showed significant changes, corresponding to histopathological examination of the temporal bones.


CONCLUSIONS
VsEPs used in assessing ototoxicity of gentamicin just as ABR.
Jiang
Z
Z
Department of Otolaryngology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. zidongjiang@263.net
Zhang
L
L
D000287:Administration, Topical; D000818:Animals; D007758:Ear, Inner / Q000187:drug effects* / Q000503:physiopathology; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D005839:Gentamicins / Q000008:administration & dosage / Q000633:toxicity*; D006168:Guinea Pigs; D007273:Injections, Intramuscular; D014722:Vestibule, Labyrinth / Q000187:drug effects / Q000503:physiopathology*
D005839:Gentamicins