title: The influence of Atorvastatin on ultrastructure of rat pancreatic exocrine cells in the course of experimental intoxication with ethanol.
abstract: The experiment was carried out on mature Wistar male rats. The animals from experimental group I received Atorvastatin in the dose 0.28 mg/24 h for 3 weeks. Experimental group II received 20% ethanol ad libitum apart from Atorvastatin. Ultrastructural examinations of pancreatic exocrine cells showed the stimulation of secretory processes in cells of animals receiving Atorvastatin and considerable damage of cell organelles in experimental group II, more intense than in the pancreas of control animals which drank ethanol.
authors.affiliation: Department of Histology and Embryology, Laboratory of Experimental Cytology, Medical University of Lublin.
authors.forename: Józef
authors.initials: J
authors.lastname: Visconti
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Celiński
authors.forename: Maria
authors.initials: M
authors.lastname: Stepniewska
authors.forename: Joanna
authors.initials: J
authors.lastname: Sekita-Krzak
mesh_terms: D000435:Alcoholic Intoxication / Q000473:pathology*; D000818:Animals; D000924:Anticholesteremic Agents / Q000633:toxicity*; D000069059:Atorvastatin; D004347:Drug Interactions; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity*; D006538:Heptanoic Acids / Q000633:toxicity*; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D019512:Pancreatitis, Alcoholic / Q000473:pathology*; D011758:Pyrroles / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D011758:Pyrroles; D000431:Ethanol; D000069059:Atorvastatin