title: Particle assembly and genome packaging.
abstract: Foamy virus (FV) replication is distinct from that of all other retroviruses in many respects, including viral assembly. In fact, the viral assembly pathway is rather similar to that of hepadnaviruses such as hepatitis B virus. Foamy virus Gag does not contain landmark retroviral assembly domains such as the major homology region, Cys-His boxes, or a defined M domain. Like hepadnaviruses, the FV Gag protein is not cleaved and contains arginine-rich regions at the carboxyl terminus. In addition, egress of FV particles requires presence of the envelope glycoproteins. Finally, the cis-acting sequences in the FV genome required for genome incorporation, although poorly defined, differ in location from other retroviruses.
authors.affiliation: Division of Basic Sciences A3-015, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, WA 98109, USA. mlinial@fhcrc.org
authors.forename: M L
authors.initials: ML
authors.lastname: Linial
authors.forename: S W
authors.initials: SW
authors.lastname: Eastman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006224:Cricetinae; D015683:Gene Products, gag / Q000235:genetics / Q000378:metabolism; D015684:Gene Products, pol / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D016679:Genome, Viral; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid; D012190:Retroviridae / Q000737:chemistry / Q000648:ultrastructure; D016415:Sequence Alignment; D016092:Spumavirus / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism*; D014771:Virion / Q000378:metabolism / Q000502:physiology; D019065:Virus Assembly; D017201:Virus Shedding
chemical_list: D015683:Gene Products, gag; D015684:Gene Products, pol; D012367:RNA, Viral; D014759:Viral Envelope Proteins