Secondary rifampin resistance following multi-drug therapy--a case report.
This is the first report of secondary resistance to rifampin following MDT in a patient with prolonged, but irregular treatment. Repeated mouse foot-pad studies demonstrated resistance to dapsone after several years of monotherapy, and following subsequent MDT the studies demonstrated the development of resistance to rifampin.
Norman
Gift
G
Department of Community Health, Schieffelin Leprosy Research and Training Center, Karigiri, Vellore-632106, India. oculep@vsnl.com
Joseph
Geetha
G
Ebenezer
Gigi
G
Rao
Sundar P
SP
Job
Charles K
CK
D003622:Dapsone / Q000494:pharmacology / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple; D004359:Drug Therapy, Combination; D006801:Humans; D007917:Leprostatic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D007918:Leprosy / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000494:pharmacology* / Q000627:therapeutic use*
D007917:Leprostatic Agents; D003622:Dapsone; D012293:Rifampin