title: The role of hyperbaric oxygen in the management of subarachnoid hemorrhage.
abstract: OBJECTIVE
  To determine the role of hyperoxic and hyperbaric therapy following experimental subarachnoid hemorrhage (SAH).
  
  
  METHODS
  Prospective, randomized, controlled animal study.
  
  
  METHODS
  Thirty male Wistar rats.
  
  
  METHODS
  Thirty rats were assessed for an initial neurologic status as double-blinded by two different neurosurgeons using a neurologic severity score (NSS) and then underwent an initial angiographic examination. Two days later, 0.3 ml of homologous blood was injected into the cisterna magna to produce a SAH-induced cerebral vasospasm. The NSS and angiographic examination were then repeated. The rats having no spasm or a spasm under 50% (n=8) and 50% or over 50% (n=22) were grouped separately, as groups 1 and 2, respectively. The rats having 50% or more spasm were further divided randomly into group 2A and 2B. The rats in groups 1 and 2A (n=11) underwent a 60-min course of 100% oxygen at the atmospheric pressure 1 atmosphere absolute (ata), and group 2B (n=11) received 100% oxygen at 3 ata for 1 h. Neurologic assessment was repeated on the next day and 7 days later.
  
  
  RESULTS
  The animals having no spasm or less than 50% spasm had a better NSS and outcome when compared with the animals having 50% or more spasm. But the animals with 50% or more spasm which underwent hyperbaric therapy were shown to have a better outcome compared to the animals having hyperoxic therapy.
  
  
  CONCLUSIONS
  Exposure to hyperbaric oxygen therapy seemed to accelerate the recovery of neurologic deficits secondary to experimental SAH.
authors.affiliation: Department of Neurosurgery, Selçuk University Medical School, Konya, Turkey. kyalcin34@hotmail.com
authors.forename: Yalçin
authors.initials: Y
authors.lastname: Kocaoğullar
authors.forename: M Erkan
authors.initials: ME
authors.lastname: Ustün
authors.forename: Emel
authors.initials: E
authors.lastname: Avci
authors.forename: Aydin
authors.initials: A
authors.lastname: Karabacakoglu
authors.forename: Damirez
authors.initials: D
authors.lastname: Fossett
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure; D002533:Cerebral Angiography; D016009:Chi-Square Distribution; D004195:Disease Models, Animal; D004311:Double-Blind Method; D006339:Heart Rate; D006931:Hyperbaric Oxygenation / Q000379:methods*; D008297:Male; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function; D012720:Severity of Illness Index; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors; D020301:Vasospasm, Intracranial / Q000209:etiology