[Role of leptin in the pathogenesis of obesity-related hypertension].
OBJECTIVE
To assess the role of leptin in the pathogenesis of obesity-related hypertension and the relationship between blood pressure (BP), and body mass index (BMI), insulin resistance and leptin were examined.


METHODS
560 non-diabetic men, aged 35 - 75, selected from volunteers of health screening test during 2 000 were divided into hypertension group (n = 321, BP >or= 140/90 mm Hg without antihypertensive medication). and normal blood pressure group (n = 239). The body weight, waist hip ratio,BP, plasma glucose, serum lipids, true insulin (TI) and leptin were measured after overnight fast. Insulin sensitivity was assessed by the HOMA insulin resistance index (HOMA-R).


RESULTS
Fasting leptin level showed good correlation with BMI, fasting TI, HOMA-R, BP and also triglycerides (all P < 0.01). After adjustment for age, BMI and HOMA-R, serum leptin was still positively correlated to SBP (r = 0.11, P < 0.05), and was significantly higher in hypertensive subjects than in normotensive subjects (geometric mean 6.4 vs 4.7 micro g/L, P < 0.001). Logistic regression analysis demonstrated that leptin remained significantly associated with hypertension after adjustment for potentially confounding factors.


CONCLUSIONS
Leptin may play an important role in the pathogenesis of obesity related hypertension.
Li
Ming
M
Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
Wu
Cong-yuan
CY
Zhan
Zhi-wei
ZW
Yang
Jing
J
Zhang
Kui
K
Li
Xiao-guang
XG
Gan
Li-hong
LH
Ji
Bao-hua
BH
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology*; D020738:Leptin / Q000097:blood*; D016015:Logistic Models; D008875:Middle Aged; D009765:Obesity / Q000150:complications*
D020738:Leptin