Numb and Numblike control cell number during vertebrate neurogenesis.
A fundamental problem in nervous system development is how to control progenitor-cell divisions to generate the correct number of cells for the mature brain and spinal cord. A recent report by Petersen and colleagues has identified an essential role for Numb and a related protein, Numblike, in this process. This study demonstrates that Numb and Numblike function to maintain the self-renewal properties of neural progenitor cells in the vertebrate neural tube.
Johnson
Jane E
JE
Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA. jane.johnson@utsouthwestern.edu
D000818:Animals; D002455:Cell Division / Q000502:physiology; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology* / Q000254:growth & development*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009024:Morphogenesis / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology*; D013234:Stem Cells / Q000378:metabolism; D014714:Vertebrates / Q000196:embryology*
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C113026:NUMB protein, human; C106292:Numbl protein, mouse