Behavioral detection of tactile stimuli during 7-12 Hz cortical oscillations in awake rats.
Prominent 7-12 Hz oscillations in the primary somatosensory cortex (S1) of awake but immobile rats might represent a seizure-like state in which neuronal burst firing renders animals unresponsive to incoming tactile stimuli; others have proposed that these oscillations are analogous to human mu rhythm. To test whether rats can respond to tactile stimuli during 7-12 Hz oscillatory activity, we trained head-immobilized awake animals to indicate whether they could detect the occurrence of transient whisker deflections while we recorded local field potentials (LFPs) from microelectrode arrays implanted bilaterally in the S1 whisker representation area. They responded rapidly and reliably, suggesting that this brain rhythm represents normal physiological activity that does not preclude perception.
Wiest
Michael C
MC
Department of Neurobiology, Box 3209, Duke Medical Center, Durham, North Carolina 27710, USA.
Nicolelis
Miguel A L
MA
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001683:Biological Clocks / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D005260:Female; D007103:Immobilization / Q000502:physiology; D010812:Physical Stimulation / Q000379:methods; D051381:Rats; D020318:Rats, Long-Evans; D011930:Reaction Time / Q000502:physiology*; D014110:Touch / Q000502:physiology*; D014738:Vibrissae / Q000502:physiology; D014851:Wakefulness / Q000502:physiology*