Hairy cell leukaemia with advanced treatment - a case report.
A case of hairy cell leukaemia (HCL), a rare leukaemia, is reported here. The patient was presented with high grade continuous fever with left upper abdominal discomfort for 6 days. He was moderately anaemic, had no peripheral lymphadenopathy with mild hepatosplenomegaly. He was anaemic (Hb-7.8 gm/dl), total leukocyte count was 20 x 109/L. Peripheral blood film showed lymphocytosis (92%) with neutropenia (8%) and absolute neutophil count (ANC) was 1 x 109/L. On review, 88% of the peripheral cells had peripheral hairy projections resembling hairy cell (HC). Bone marrow examination was consistent with HCL (morrow hairy cell = 52%) including marker studies. Tartrate resistant acid phosphatase test (TRAP) was also positive. He had opportunistic mycobecterial infection giving a positive bronchial lavage for acid fast bacilli. After controlling the infection he was advised a single dose chemotherapy of 2-chlorodeoxyadenosine (2-CDA). After that he was in partial remission and after 25 months clinical and pathological relapses occurred and a second dose of 2-CDA was given and the patient went into complete remission.
Momen
A
A
Assistant Registrar, Department of Medicine, MMCH, Bangladesh.
Sarker
C B
CB
Siddiqui
N I
NI
Huq
M H
MH
Jamal
M F
MF
Talukder
S I
SI
Rahman
K M
KM
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000627:therapeutic use; D001856:Bone Marrow Examination; D017338:Cladribine / Q000627:therapeutic use*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D009164:Mycobacterium Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D012074:Remission Induction; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D017338:Cladribine