Epidemiological, clinical, and prognostic differences between the diseases caused by Mycobacterium kansasii and Mycobacterium tuberculosis in patients infected with human immunodeficiency virus: a multicenter study.
A multicenter, comparative study was performed to determine the epidemiological, clinical, and prognostic differences between the diseases caused by Mycobacterium tuberculosis and Mycobacterium kansasii in human immunodeficiency virus (HIV)-infected patients. From 1 January 1995 through 31 December 1999, 25 HIV-infected patients received diagnoses of M. kansasii infection, and another 75 were selected as control subjects from among patients who had M. tuberculosis infection. Variables associated with M. tuberculosis disease in the multivariate analysis were previous intravenous drug use (odds ratio [OR], 8; 95% confidence interval [CI], 1.5-41.4) and interstitial radiologic pattern (OR, 12.7; 95% CI, 1.7-94.3). Variables associated with M. kansasii were previous diagnosis of acquired immunodeficiency syndrome (OR, 15.8; 95% CI, 4.2-59.6) and concomitant opportunistic infections (OR, 14.2; 95% CI, 2-105.7). Clinical and radiologic features were similar for both groups, but epidemiological characteristics and prognosis were different. M. kansasii disease was associated more closely with level of immunosuppression and progression of HIV infection than was disease caused by M. tuberculosis.
Canueto-Quintero
Jesús
J
Infectious Diseases Section, Punta de Europa Hospital, Algeciras, Spain. j.canueto@comcadiz.com
Caballero-Granado
Francisco Javier
FJ
Herrero-Romero
Marta
M
Domínguez-Castellano
Angel
A
Martín-Rico
Patricia
P
Verdú
Elisa Vidal
EV
Santamaría
Daniel Selma
DS
Cerquera
Ricardo Creagh
RC
Torres-Tortosa
Manuel
M
D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology*; D000328:Adult; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000503:physiopathology*; D019909:Mycobacterium kansasii; D009169:Mycobacterium tuberculosis; D014397:Tuberculosis, Pulmonary / Q000503:physiopathology*