title: Antioxidant properties of scopoletin isolated from Sinomonium acutum.
abstract: Scopoletin was isolated from Sinomonium acutum and studied using four experimental models designed to assess antioxidant properties. The results indicated that scopoletin scavenged superoxide anion in the xanthine/xanthine oxidase reaction system in a concentration-dependent manner, but did not inhibit xanthine oxidase. Scopoletin may therefore be responsible for the superoxide anion scavenging activity seen in Sinomonium acutum extracts and may be of use in preventing superoxide anion-induced damage in vivo.
authors.affiliation: Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan, Republic of China.
authors.forename: Chin-Ying
authors.initials: CY
authors.lastname: Shaw
authors.forename: Chen-Hui
authors.initials: CH
authors.lastname: Chen
authors.forename: Chih-Chieh
authors.initials: CC
authors.lastname: Hsu
authors.forename: Chien-Chih
authors.initials: CC
authors.lastname: Chen
authors.forename: Ying-Chieh
authors.initials: YC
authors.lastname: Tsai
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001713:Biphenyl Compounds; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006861:Hydrogen Peroxide; D017665:Hydroxyl Radical; D008517:Phytotherapy; D010851:Picrates; D018547:Plant Stems / Q000737:chemistry; D012603:Scopoletin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D032841:Sinomenium / Q000737:chemistry*; D013481:Superoxides
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D010851:Picrates; D013481:Superoxides; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl; D012603:Scopoletin