Novel P,N-bidentate phosphite ligands in asymmetric catalysis.
Results achieved by the authors in the synthesis of chiral P,N-phosphite ligands are summarized. Three groups of new chiral P,N-phosphites are discussed, namely, ligands derived from 1,1'-bi-2-naphthol, ligands possessing an acyclic phosphorus center, and P*-chiral ligands derived from (S)-2-anilinomethylpyrrolidine. An overview of complexation of the ligands with Rh(I) and Pd(II) precursors is given. Accessibility and stability of chiral phosphite ligands possessing acyclic phosphorus was analyzed for the first time along with their efficiency in terms of stereoselectivity. The title ligands are shown to be highly efficient in the Pd-catalyzed allylic alkylation (up to 85% ee) and, especially, allylic sulfonylation (up to 97% ee) reactions in certain cases outperformed all known catalytic systems.
Gavrilov
Konstantin N
KN
Department of Chemistry, Ryazan State Pedagogic University, Ryazan, Russia.
Bondarev
Oleg G
OG
Korostylev
Andrei V
AV
Polosukhin
Alexei I
AI
Tsarev
Vassily N
VN
Kadilnikov
Nikolay E
NE
Lyubimov
Sergey E
SE
Shiryaev
Alexei A
AA
Zheglov
Sergey V
SV
Gais
Hans-Joachim
HJ
Davankov
Vadim A
VA