title: TT virus loads and lymphocyte subpopulations in children with acute respiratory diseases.
abstract: TT virus (TTV) produces chronic plasma viremia in around 90% of healthy individuals of all ages and has, therefore, been proposed as a commensal human virus. We recently demonstrated that in children hospitalized for acute respiratory diseases high TTV loads were associated with severe forms of disease. Here, we report that in such children TTV loads showed an inverse correlation with the percentage of circulating total T and helper T cells and a direct correlation with the percentage of B cells. Thus, florid TTV replication might contribute to lymphocyte imbalances and, possibly, immunosuppressive effects, thus resembling related animal viruses.
authors.affiliation: Virology Section and Retrovirus Center, Department of Experimental Pathology, University of Pisa, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Maggi
authors.forename: Massimo
authors.initials: M
authors.lastname: Pifferi
authors.forename: Elena
authors.initials: E
authors.lastname: Tempestini
authors.forename: Claudia
authors.initials: C
authors.lastname: Fornai
authors.forename: Letizia
authors.initials: L
authors.lastname: Lanini
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Andreoli
authors.forename: Marialinda
authors.initials: M
authors.lastname: Vatteroni
authors.forename: Silvano
authors.initials: S
authors.lastname: Presciuttini
authors.forename: Angelo
authors.initials: A
authors.lastname: Pietrobelli
authors.forename: Attilio
authors.initials: A
authors.lastname: Boner
authors.forename: Mauro
authors.initials: M
authors.lastname: Pistello
authors.forename: Mauro
authors.initials: M
authors.lastname: Bendinelli
mesh_terms: D000208:Acute Disease; D002648:Child; D004279:DNA, Viral / Q000097:blood; D006801:Humans; D016131:Lymphocyte Subsets; D012140:Respiratory Tract Diseases / Q000821:virology*; D022783:Torque teno virus / Q000235:genetics / Q000302:isolation & purification*; D019562:Viral Load
chemical_list: D004279:DNA, Viral