title: Suspected lamotrigine-induced toxic epidermal necrolysis.
abstract: Toxic epidermal necrolysis and Stevens-Johnson syndrome are rare, life treating cutaneous reactions. Most cases of toxic epidermal necrolysis are drug induced. The drugs with the highest estimated incidence include co-trimoxazloe (trimethoprim-sulfamethoxazole), sulfadoxine-pyrethamine, and carbamazepine. Among other drugs, the reported reaction rates are relatively low for lamotrigine and sulbactam-ampicillin. We describe a patient who developed toxic epidermal necrolysis after either administration of lamotrigine or of ampicillin.
authors.affiliation: Baskent University Faculty of Medicine, Neurology Department.
authors.forename: Aysegül
authors.initials: A
authors.lastname: Söğüt
authors.forename: Aynur
authors.initials: A
authors.lastname: Yilmaz
authors.forename: Münire
authors.initials: M
authors.lastname: Kilinç
authors.forename: Arif G
authors.initials: AG
authors.lastname: Söğüt
authors.forename: Ebru
authors.initials: E
authors.lastname: Demiralay
authors.forename: Hatice
authors.initials: H
authors.lastname: Uzar
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D020190:Myoclonic Epilepsy, Juvenile / Q000188:drug therapy; D012867:Skin / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000209:etiology*; D014227:Triazines / Q000009:adverse effects* / Q000627:therapeutic use; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D014635:Valproic Acid; D000077213:Lamotrigine