Fatal lactic acidosis and mimicking Guillain-Barré syndrome in an adolescent with human immunodeficiency virus infection.
We report a case of antiretroviral therapy-related fatal lactic acidosis occurring in a vertically infected HIV-positive 17-year-old patient. While receiving antiretroviral therapy with stavudine, didanosine, tenofovir and amprenavir, the patient developed severe acidosis and rapid neuromuscular and respiratory failure mimicking Guillain-Barré syndrome.
Rosso
Rafaella
R
Department of Infectious Diseases, University of Genoa, School of Medicine, San Martino Hospital, Italy. raffaellarusso@hotmail.com
Di Biagio
Antonio
A
Ferrazin
Antonio
A
Bassetti
Matteo
M
Ciravegna
Barbara Wenda
BW
Bassetti
Dante
D
D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives*; D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D002219:Carbamates; D003937:Diagnosis, Differential; D016049:Didanosine / Q000008:administration & dosage; D018450:Disease Progression; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D005663:Furans; D020275:Guillain-Barre Syndrome / Q000175:diagnosis*; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000635:transmission; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000009:adverse effects; D018570:Risk Assessment; D012720:Severity of Illness Index; D018119:Stavudine / Q000009:adverse effects; D013449:Sulfonamides / Q000009:adverse effects; D000068698:Tenofovir
D002219:Carbamates; D005663:Furans; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D013449:Sulfonamides; C095108:amprenavir; D000068698:Tenofovir; D018119:Stavudine; D000225:Adenine; D016049:Didanosine