[Studies on the phenolic acid constituents from Chinese medicine "sheng-ma", rhizome of Cimicifuga foetida L].
OBJECTIVE
To look for new active constituents from Chinese medicine "Sheng-ma", rhizome of Cimicifuga foetida L.


METHODS
The compounds were separated and purified by chromatography on silica gel and Sephadex LH-20. Their structures were determined by spectral analysis and chemical reaction.


RESULTS
Eight compounds were obtained and identified as cimicifugic acid (1), esculetin (2), caffeic acid methyl ester (3), 4-O-acetyl-caffeic acid (4), sinapic acid (5), caffeic acid (6), ferulic acid (7), isoferulic acid (8).


CONCLUSIONS
Compound 1 is a new compound, and compounds 2-7 were isolated from this plant for the first time.
Zhao
Xiao-hong
XH
Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China.
Chen
Di-hua
DH
Si
Jian-yong
JY
Pan
Rui-le
RL
Shen
Lian-gang
LG
D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification*; D031885:Cimicifuga / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification*; D008968:Molecular Conformation; D015394:Molecular Structure; D010648:Phenylacetates / Q000737:chemistry / Q000302:isolation & purification*; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry*; D014468:Umbelliferones / Q000737:chemistry / Q000302:isolation & purification
D002109:Caffeic Acids; D003373:Coumaric Acids; D004365:Drugs, Chinese Herbal; D062385:Hydroxybenzoates; D010648:Phenylacetates; D014468:Umbelliferones; C116092:cimicifugic acid; C073734:sinapinic acid; C017616:phenolic acid; C007628:esculetin