[Growth factor and regeneration of intervertebral disc].
OBJECTIVE
To review research progress of the relation between growth factor and repair of intervertebral disc.


METHODS
The recent articles on growth factor and repair of intervertebral disc were extensively reviewed. The expression of growth factor in intervertebral disc and the effect of growth factor on disc cells were investigated.


RESULTS
Some growth factors play roles in the development and degeneration of intervertebral disc. Exogenous growth factor can increase proliferation of disc cells and production of proteoglycans and collagens. Gene of growth factor can be transferred to intervertebral disc cell by adenovirus.


CONCLUSIONS
Growth factor plays an important role in the regulation of development and degeneration of interertebral disc. The above results show that the feasibility of usage of growth factor in the treatment of disc degeneration and in repair and reconstruction of disc.
Wang
Fei
F
Department of Spine Surgery, Nanfang Hospital, First Military University, Gungzhou, Guangdong, P. R. China 510515.
Qu
Dong-bin
DB
Jin
Da-di
DD
D002455:Cell Division; D004815:Epidermal Growth Factor / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D018014:Gene Transfer Techniques; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism / Q000502:physiology*; D011509:Proteoglycans / Q000096:biosynthesis; D012038:Regeneration; D014162:Transfection; D015291:Transforming Growth Factors / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*
D011509:Proteoglycans; D004815:Epidermal Growth Factor; D015291:Transforming Growth Factors