title: Results and complications of hydrophobic acrylic vs PMMA posterior chamber lenses in children under 17 years of age.
abstract: OBJECTIVE
  To compare results and complications of implantation of hydrophobic acrylic foldable intraocular lenses in children with those of polymethylmethacrylate (PMMA) intraocular lenses.
  
  
  METHODS
  In a retrospective study, we analyzed results of cataract surgery with posterior chamber lens implantation in 30 eyes of 30 patients aged 1-16 years. In 10 eyes, acrylic (Alcon AcrySof) intraocular lenses, and in 20 eyes, single-piece PMMA posterior chamber lenses were implanted. Indications for cataract surgery (blunt or penetrating trauma, zonular cataract, cataracta polaris posterior, posterior lenticonus) and mean age at implantation were comparable in the two groups. Mean patient age at surgery was 8.6+/-4.6 years (range 3-16 years) for the acrylic vs 6.3+/-4.3 years (range 1-16 years) for the PMMA group. Mean follow-up was 1.0+/-0.7 years (range 0.1-2.2 years) in the acrylic group and 1.8+/-1.5 years (range 0.1-5.7 years) in the PMMA group. Primary anterior vitrectomy was performed in 7 eyes in the PMMA group and in 3 eyes in the acrylic group. In addition, one additional posterior capsulorhexis without anterior vitrectomy was performed in each group. Primary outcome measure was the occurrence of postoperative "complications" (fibrin, synechiae, posterior capsular opacification). For statistical evaluation, the Fisher exact test was used.
  
  
  RESULTS
  When evaluating all complications together (at least one complication vs no complication), there were significantly less complications in the acrylic group (2 of 10 vs 15 of 20; p=0.007. For early complications (postoperative fibrin, synechiae) the difference was also significant (1 of 10 in the acrylic vs 11 of 20 in the PMMA group; p=0.02). The rate of posterior capsular opacification necessitating YAG capsulotomy was lower in the acrylic group (1 of 10 eyes) than in the PMMA group (7 of 20 eyes), but the difference did not reach statistical significance ( p=0.67). The postoperative time point of YAG capsulotomy was 21 months in the acrylic group and 19+/-10 months (range 6-33 months) in the PMMA group. IOL dislocation was not observed in any of the patients. Postoperative visual acuity was comparable in the two groups: 0.57+/-0.35 (0.03-1.0) in the acrylic vs 0.39+/-0.34 (0.001-0.9) in the PMMA group ( p=0.83).
  
  
  CONCLUSIONS
  Implantation of hydrophobic acrylic intraocular lenses in the capsular bag in children may be associated with less postoperative complications compared with implantation of PMMA lenses. This appears also to be true in children under age 6 years. The visual results seem comparable and correspond mainly to the underlying ocular pathology.
authors.affiliation: Department of Ophthalmology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany. kuechle@augen.imed.uni-erlangen.de
authors.forename: Michael
authors.initials: M
authors.lastname: Küchle
authors.forename: Berthold
authors.initials: B
authors.lastname: Lausen
authors.forename: Gabriele-Charlotte
authors.initials: GC
authors.lastname: Gusek-Schneider
mesh_terms: D000179:Acrylates; D000293:Adolescent; D002386:Cataract / Q000453:epidemiology / Q000209:etiology; D002387:Cataract Extraction; D005260:Female; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D015994:Incidence; D053685:Laser Therapy; D007908:Lens, Crystalline / Q000601:surgery; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008297:Male; D019904:Polymethyl Methacrylate; D012189:Retrospective Studies; D014792:Visual Acuity
chemical_list: D000179:Acrylates; D019904:Polymethyl Methacrylate