babA2- and cagA-positive Helicobacter pylori strains are associated with duodenal ulcer and gastric carcinoma in Brazil.
The babA2 and cagA genes were investigated in 208 Brazilian Helicobacter pylori strains. A strong association between babA2 and duodenal ulcer or gastric carcinoma was observed, even after adjusting for confounding factors, such as age, gender, and cagA status. cagA-positive strains were also independently associated with H. pylori-related diseases.
Oliveira
Adriana Gonçalves
AG
Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Santos
Adriana
A
Guerra
Juliana Becattini
JB
Rocha
Gifone Aguiar
GA
Rocha
Andreia Maria Camargos
AM
Oliveira
Celso Affonso
CA
Cabral
Mônica Maria Demas Alvares
MM
Nogueira
Ana Margarida Miguel Ferreira
AM
Queiroz
Dulciene Maria Magalhães
DM
D018829:Adhesins, Bacterial / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000942:Antigens, Bacterial / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D001938:Brazil / Q000453:epidemiology; D002352:Carrier Proteins / Q000235:genetics; D004381:Duodenal Ulcer / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D005756:Gastritis / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000382:microbiology*
D018829:Adhesins, Bacterial; D000942:Antigens, Bacterial; C400429:BabA protein, Helicobacter pylori; D001426:Bacterial Proteins; D002352:Carrier Proteins; C080866:cagA protein, Helicobacter pylori