Necrobiotic xanthogranuloma associated with a benign monoclonal gammopathy.
Necrobiotic xanthogranuloma (NXG) is a disorder characterized by indurated, yellow-red nodules or plaques, primarily involving the face and, less frequently, the trunk and extremities. NXG may be associated with paraproteinemia, multiple myeloma, and hypertension. Histologically, xanthogranulomatous features with hyaline necrosis or necrobiosis are present. No first-line treatment has been established. This disease is a chronic process, and a patient's prognosis depends on the degree of extracutaneous involvement and the presence of visceral malignancies. We describe a patient with typical cutaneous and histologic findings of NXG with an associated monoclonal gammopathy.
Burdick
Anne E
AE
Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Florida 33136, USA. aburdick@med.miami.edu
Sanchez
Jany
J
Elgart
George W
GW
D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D006099:Granuloma / Q000150:complications / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications / Q000473:pathology*; D017441:Necrobiotic Disorders / Q000150:complications / Q000473:pathology*; D018570:Risk Assessment; D012720:Severity of Illness Index; D014973:Xanthomatosis / Q000150:complications / Q000473:pathology*