title: [Effect of chloroform and ether narcosis on the activity of basic carboxypeptidases in the hypothalamic-pituitary-adrenal axis in rats].
abstract: It is discovered that chloroform narcosis does not influence on carboxypeptidase H and phenylmethylsulfonyl fluoride-inhibited carboxypeptidase activity in the rats hypothalamic-pituitary-adrenal axis. Ether narcosis provokes an increase of PMSF-inhibited carboxypeptidase activity in the pituitary body approximately in 8 times and carboxypeptidase H activity in hypothalamus by 29 percents in comparison with the intact animals. It is supposed that at research neuropeptides and their metabolism enzymes and especially the answer to a stress chloroform narcosis would be the better anaesthesia method than ether narcosis.
authors.affiliation: Penza State Pedagogical University, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Vernigora
authors.forename: M T
authors.initials: MT
authors.lastname: Gengin
authors.forename: E S
authors.initials: ES
authors.lastname: Mukhina
authors.forename: O E
authors.initials: OE
authors.lastname: Mikhaĭlova
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D043423:Carboxypeptidase H / Q000378:metabolism; D002268:Carboxypeptidases / Q000378:metabolism*; D002725:Chloroform / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004986:Ether / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000201:enzymology*; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000201:enzymology*; D051381:Rats
chemical_list: D018685:Anesthetics, Inhalation; D004791:Enzyme Inhibitors; D004986:Ether; D010664:Phenylmethylsulfonyl Fluoride; D002725:Chloroform; D002268:Carboxypeptidases; D043423:Carboxypeptidase H