A unification of mosaic structures in the human genome.
The human genome is a mosaic structure on many levels: there exist cytogenetic bands, GC composition bands (isochores) and clusters of broadly expressed genes. How might these inter-relate? It has been proposed that to optimize gene regulation, housekeeping genes should concentrate on transcriptionally competent chromosomal domains. Prior evidence suggests that regions of high GC and R bands are associated with such domains. Here we report that broadly expressed genes cluster in regions of high GC, and in R and lightest Giemsa bands. This is not only a confirmation of the adaptive hypothesis, but is also the first direct systematic evidence of a general interdependence of expression patterns with base composition and chromosome structure.
Lercher
Martin J
MJ
Department of Biology and Biochemistry, University of Bath, UK. m.j.lercher@bath.ac.uk
Urrutia
Araxi O
AO
Pavlícek
Adam
A
Hurst
Laurence D
LD
D001399:Azure Stains / Q000378:metabolism; D001482:Base Composition; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000737:chemistry / Q000378:metabolism*; D002880:Chromosomes, Human, Pair 11; D020224:Expressed Sequence Tags; D020862:GC Rich Sequence; D005786:Gene Expression Regulation; D023061:Gene Order; D005796:Genes / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007438:Introns; D032085:Isochores / Q000737:chemistry / Q000235:genetics*; D016014:Linear Models; D012333:RNA, Messenger / Q000737:chemistry; D011995:Recombination, Genetic; D014158:Transcription, Genetic
D001399:Azure Stains; D032085:Isochores; D012333:RNA, Messenger