Control of photo-induced drug release by the use of conformational change of DNA.
Photo-induced drug release system which was controlled by triplet quenching using the molecular beacon strategy of photoreactive oligodeoxynucleotides (P-ODN) was developed. The strand ends of P-ODN were modified with a phenacyl ester of biotin and naphthalene as photoreactive group and triplet quencher, respectively. Photoirradiation to P-ODN in the presence of complementary DNA caused an efficient release of biotin. In contrast, the biotin release was suppressed in the absence of complementary DNA by the intramolecular triplet quenching in the stem-and-loop structure of P-ODN.
Tanabe
Kazuhito
K
Department of Energy and Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606-8501, Japan.
Inasaki
Takeshi
T
Okamoto
Akimitsu
A
Nishimoto
Sei-ichi
S
Saito
Isao
I
D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D016503:Drug Delivery Systems; D009690:Nucleic Acid Conformation; D010777:Photochemistry
D004247:DNA