Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori.
To search for cancer chemopreventive agents from natural resources, many phytochemicals and food additives have been screened. Consequently, two natural sweeteners, mogroside V and 11-oxo-mogroside V isolated from the fruits of Momordica grosvenori, exhibited strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen (EBV-EA) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). These sweet glycosides, having cucurbitane triterpenoid aglycon, exhibited the significant inhibitory effects on the two-stage carcinogenesis test of mouse skin tumors induced by peroxynitrite (ONOO-) as an initiator and TPA as a promoter. Further, 11-oxo-mogroside V also exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumor induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.
Takasaki
Midori
M
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. midori@mb.kyoto-phu.ac.jp
Konoshima
Takao
T
Murata
Yuji
Y
Sugiura
Masaki
M
Nishino
Hoyoku
H
Tokuda
Harukuni
H
Matsumoto
Kazuhiro
K
Kasai
Ryoji
R
Yamasaki
Kazuo
K
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D003043:Cocarcinogenesis; D005260:Female; D008214:Lymphocytes; D051379:Mice; D008813:Mice, Inbred ICR; D029775:Momordica / Q000737:chemistry*; D030421:Peroxynitrous Acid / Q000494:pharmacology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D013549:Sweetening Agents / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate; D014315:Triterpenes / Q000494:pharmacology*
C477379:11-oxo-mogroside V; D016588:Anticarcinogenic Agents; D013549:Sweetening Agents; D014315:Triterpenes; D030421:Peroxynitrous Acid; D015127:9,10-Dimethyl-1,2-benzanthracene; C041740:mogroside V; D013755:Tetradecanoylphorbol Acetate