title: A novel vitamin D-regulated immediate-early gene, IEX-1, alters cellular growth and apoptosis.
abstract: 1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3) inhibits the expression of an immediate-early gene, IEX-1, which is involved in the regulation of cellular growth and apoptosis in a variety of cells. 1alpha,25(OH)2D3 alters the subcellular localization of IEX-1 by causing an efflux of IEX-1 from the nucleus, and the sterol decreases the expression of IEX-1 messenger RNA in cells via a novel DR3 repeat-type DNA response element.
authors.affiliation: Department of Medicine, Mayo Clinic and Foundation, 911A Guggenheim Building, 200 First Street S.W., Rochester, MN 55905, USA. rkumar@mayo.edu
authors.forename: Rajiv
authors.initials: R
authors.lastname: Kumar
authors.forename: Mark R
authors.initials: MR
authors.lastname: Pittelkow
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Salisbury
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Grande
authors.forename: Hee-Jeong
authors.initials: HJ
authors.lastname: Im
authors.forename: Kathrin A
authors.initials: KA
authors.lastname: Feldmann
authors.forename: David
authors.initials: D
authors.lastname: Schilling
mesh_terms: D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D002117:Calcitriol / Q000494:pharmacology*; D002455:Cell Division; D002467:Cell Nucleus / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D021381:Protein Transport; D020218:Response Elements / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D051017:Apoptosis Regulatory Proteins; C099815:IER3 protein, human; D017874:Immediate-Early Proteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D002117:Calcitriol