title: Synthesis of N2 2'-deoxyguanosine adducts formed by 1-nitropyrene.
abstract: [reaction: see text] Synthesis of N(2) 2'-deoxyguanosine adducts formed by the ubiquitous carcinogen, 1-nitropyrene, is reported. Various conditions of Buchwald-Hartwig palladium-catalyzed amination are examined. The most convenient synthetic approach involved a straightforward coupling between protected 2'-deoxyguanosine and bromonitropyrenes, which, upon reductive deprotection, provided excellent yield of the two 1-nitropyrene adducts.
authors.affiliation: Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, USA.
authors.forename: Debasis
authors.initials: D
authors.lastname: Chakraborti
authors.forename: Laureen
authors.initials: L
authors.lastname: Colis
authors.forename: Renee
authors.initials: R
authors.lastname: Schneider
authors.forename: Ashis K
authors.initials: AK
authors.lastname: Basu
mesh_terms: D003849:Deoxyguanosine / Q000138:chemical synthesis* / Q000737:chemistry; D011721:Pyrenes / Q000737:chemistry*
chemical_list: D011721:Pyrenes; D003849:Deoxyguanosine; C032668:1-nitropyrene