title: [Locoregional chemotherapy of locally advanced breast cancer in a pre-treated patient: case report].
abstract: We report of the use of intra-arterial chemotherapy in one case of locally advanced breast cancer, that had been systemically pre-treated. Locoregional chemotherapy was delivered via percutaneous access. The catheter tip was placed into the subclavian artery and into origin of the internal mammary artery; it was removed after every cycle of treatment. The schedule of chemotherapy was: epirubicin 30 mg/m2, mitomycin 7 mg/m2 and 5 fluouracil 1000 mg. Three cycles were administered, and the treatment was well tolerated. The patient responded to intra-arterial chemotherapy, and she subsequently underwent complete surgical resection. Intra-arterial chemotherapy for breast cancer in an uncommon approach to the treatment of locally advanced disease. Nevertheless, in selected cases, it could be a more effective therapeutic option for patients with systemic chemotherapy-resistant disease.
authors.affiliation: UO Chirurgia Generale 2, Modulo di Chirurgia Oncologica, Ospedale GB Morgagni-Pierantoni, Forlì.
authors.forename: A
authors.initials: A
authors.lastname: Vagliasindi
authors.forename: L
authors.initials: L
authors.lastname: Valmori
authors.forename: A
authors.initials: A
authors.lastname: Bertagni
authors.forename: A
authors.initials: A
authors.lastname: Campisi
authors.forename: C
authors.initials: C
authors.lastname: Milandri
authors.forename: E
authors.initials: E
authors.lastname: Gianpalma
authors.forename: F
authors.initials: F
authors.lastname: Calzolai
authors.forename: D R
authors.initials: DR
authors.lastname: Golfieri
authors.forename: G M
authors.initials: GM
authors.lastname: Verdecchia
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D047072:Aromatase Inhibitors; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D007261:Infusions, Intra-Arterial; D008323:Mammary Arteries; D008408:Mastectomy / Q000379:methods; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D020360:Neoadjuvant Therapy; D012883:Skin Ulcer / Q000209:etiology
chemical_list: D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D015251:Epirubicin; D016685:Mitomycin; D003520:Cyclophosphamide; D005472:Fluorouracil; D006854:Hydrocortisone; D008727:Methotrexate