Genetics in rheumatoid arthritis.
This chapter reviews the latest original research on the genetics of rheumatoid arthritis (RA), with a focus on its relevance for the clinical rheumatologist. The following questions will be dealt with in order to appreciate the recent progress in this field. * Why is a knowledge of genetics useful for an understanding of the pathogenesis of RA? * Is a knowledge of genetic risk factors relevant for day-to-day clinical practice? * What methods are used for identifying genetic risk factors? * Which genetic regions have been identified in susceptibility to RA? * What risk factors have been identified? * What are the future prospects and research agenda?
Huizinga
Tom W J
TW
Department of Rheumatology, C4-R, Leiden University Medical Center, P.O. Box 9600, RC 2300, Leiden, The Netherlands. t.w.j.huizinga@lumc.nl
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005826:Genetics, Medical; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D012307:Risk Factors
D006680:HLA Antigens