Effects of aminoglycoside antibiotics on renal antioxidants, malondialdehyde levels, and some serum biochemical parameters.
Effects of amikacin, gentamicin, kanamycin, and streptomycin on renal tissue superoxide dismutase, glutathione peroxidase, glutathione and malondialdehyde, serum creatinine, potassium, sodium, total protein, glucose, uric acid, and total bilirubin levels were investigated. All aminoglycoside antibiotics decreased renal tissue glutathione levels.
Yazar
Enver
E
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey. eyazar@selcuk.edu.tr
Elmas
Muammer
M
Altunok
Vahdettin
V
Sivrikaya
Abdullah
A
Oztekin
Esma
E
Birdane
Yavuz Osman
YO
D000617:Aminoglycosides / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism*; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D003404:Creatinine / Q000097:blood; D005979:Glutathione Peroxidase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D011188:Potassium / Q000097:blood; D011897:Random Allocation; D012964:Sodium / Q000097:blood; D013482:Superoxide Dismutase / Q000378:metabolism; D014527:Uric Acid / Q000097:blood
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001786:Blood Glucose; D001798:Blood Proteins; D014527:Uric Acid; D008315:Malondialdehyde; D012964:Sodium; D003404:Creatinine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001663:Bilirubin; D011188:Potassium