[Clinical observation and histological research of vocal cord's reformation after laser cordectomy].
OBJECTIVE
Explore the reformation of new vocal cord after laser cordectomy and the histological change of new vocal cord by animal experiment.


METHODS
The reforming course of new vocal cord was observed by follow-up. 4 dogs underwent bilateral cordectomy (type II operation) and their larynx were analyzed anatomically and histologically eight months later. 100 cases who underwent KTP laser cordectomy were divided into 3 types according to the range and depth of the excision.


RESULTS
All the dogs had reformation of vocal cords eight months later. On the surface of the reformed vocal cord, no mucous cell but squamous cells was found. Newborn ligament-like connective tissues and loose muscle fibers were found under membrane. Complete reconstruction of larynx was found in 16 cases of type I (16/16) and 54 of type II 86% (54/63). But in type III no new vocal cord was found.


CONCLUSIONS
Formation of the new vocal cord is the result of hypertrophy of the remained vocal cord muscle, influenced by depth of the excised vocal cord using laser. The histological construction is nearly normal cord. Whether or not the laser radiation stimulate the tissue hypertrophy is need more research.
Yang
Huai-an
HA
Department of Otorhinolaryngology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China. huaian@online.ln.cn
Ji
Wen-yue
WY
Guo
Xing
X
Cao
Zhi-wei
ZW
Pan
Zi-min
ZM
Ren
Zhong
Z
D000328:Adult; D000368:Aged; D000818:Animals; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007825:Laryngectomy; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D014827:Vocal Cords / Q000473:pathology* / Q000601:surgery