Operation kinetics of a DNA-based molecular switch.
The influence of temperature variation, salt concentration, and pH on the operation kinetics of a simple DNA-based molecular switch is investigated. The device shows robust behavior over a wide range of temperatures, pH, and salt concentrations. In particular, the device operates well under physiological conditions. The experimental data can be qualitatively understood in terms of the influence temperature, salt concentration, and pH have on DNA strand interactions.
Simmel
Friedrich C
FC
Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey, USA.
Yurke
Bernard
B
Sanyal
Rishi J
RJ
D039301:Computers, Molecular; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D004867:Equipment Design; D031541:Fluorescence Resonance Energy Transfer / Q000379:methods; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008422:Materials Testing / Q000379:methods; D020409:Molecular Motor Proteins / Q000138:chemical synthesis / Q000737:chemistry*; D009038:Motion; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods; D009690:Nucleic Acid Conformation; D012680:Sensitivity and Specificity; D012965:Sodium Chloride / Q000737:chemistry; D013696:Temperature
D020409:Molecular Motor Proteins; D012965:Sodium Chloride; D004247:DNA