title: Four glycosides from the leaves of Abeliophyllum distichum with inhibitory effects on angiotensin converting enzyme.
abstract: The bioassay-guided fractionation of the n-BuOH extract of Abeliophyllum distichum afforded acteoside (1), isoacteoside (2), rutin (3), and hirsutrin (4). Compounds 1-3 moderately inhibited the angiotensin I converting enzyme activity in a dose-dependent manner. Compounds 1-3 showed the 50% inhibitory concentration values of 228 micro g/mL, 290 micro g/mL, and 278 micro g/mL, respectively.
authors.affiliation: Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, Republic of Korea.
authors.forename: Hyuncheol
authors.initials: H
authors.lastname: Oh
authors.forename: Dae-Gill
authors.initials: DG
authors.lastname: Kang
authors.forename: Tae-Oh
authors.initials: TO
authors.lastname: Kwon
authors.forename: Kyu Kwan
authors.initials: KK
authors.lastname: Jang
authors.forename: Kyu-Yun
authors.initials: KY
authors.lastname: Chai
authors.forename: Young-Gab
authors.initials: YG
authors.lastname: Yun
authors.forename: Hun-Taeg
authors.initials: HT
authors.lastname: Chung
authors.forename: Ho-Sub
authors.initials: HS
authors.lastname: Lee
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000494:pharmacology; D006027:Glycosides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D029592:Oleaceae; D007703:Peptidyl-Dipeptidase A / Q000187:drug effects*; D010636:Phenols / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D012431:Rutin / Q000494:pharmacology; D059808:Polyphenols
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D005960:Glucosides; D006027:Glycosides; D007703:Peptidyl-Dipeptidase A; D010636:Phenols; D010936:Plant Extracts; D012431:Rutin; C058956:acteoside; D059808:Polyphenols; C064683:isoacteoside