Selective aldosterone blockade reduces mortality after MI.
Eplerenone, a selective mineralocorticoid receptor antagonist currently approved by the Food and Drug Administration for treatment of hypertension, reduces mortality following myocardial infarction in patients with left ventricular dysfunction and clinical signs of congestive heart failure. Previous research by the same group established that spironolactone does the same at lower cost than eplerenone.
Stephens
Mark B
MB
Flight Line Clinic Naval Hospital, Sigonella, Italy. mbstephens@sig.med.navy.mil