Robert Feulgen Prize Lecture. Grenzgänger: adult bone marrow cells populate the brain.
While the brain has traditionally been considered a rather secluded site, recent studies suggest that adult bone marrow (BM)-derived stem cells can generate glia and neurons in rodents and humans. Macrophages and microglia are the first to appear in the murine brain after transplantation of genetically marked BM cells. Within weeks after transplantation, some authors have found astrocytes and cells expressing neuronal antigens. We detected cerebellar Purkinje neurons and interneurons, such as basket cells, expressing the green fluorescent protein (GFP) 10-15 months after transplantation of GFP-labeled BM cells. The results push the boundaries of our classic view of lineage restriction.
Priller
Josef
J
Department of Neurology, Charité, Humboldt-University, Schumannstrasse 20/21, 10117 Berlin, Germany. josef.priller@charite.de
D000328:Adult; D000818:Animals; D001253:Astrocytes / Q000166:cytology; D016026:Bone Marrow Transplantation; D001921:Brain / Q000166:cytology* / Q000378:metabolism; D002454:Cell Differentiation; D049452:Green Fluorescent Proteins; D006651:Histocytochemistry; D006801:Humans; D008164:Luminescent Proteins / Q000378:metabolism; D051379:Mice; D017628:Microglia / Q000166:cytology; D009473:Neuronal Plasticity; D011689:Purkinje Cells / Q000166:cytology / Q000378:metabolism; D033581:Stem Cell Transplantation; D023001:Transplantation Tolerance
D008164:Luminescent Proteins; D049452:Green Fluorescent Proteins