Osteoporosis: genetic analysis of multifactorial disease.
Osteoporosis is a common disorder with a complex pathophysiology involving both endogenous and environmental factors. Family and twin studies have shown that genetic factors play an essential role in bone mass regulation and that apart from rare instances the heritability of bone mineral density (BMD) and osteoporosis is polygenic. Linkage analysis and association studies with numerous DNA markers (single nucleotide polymorphisms or microsatellites) have analysed several bone-related candidate genes encoding vitamin D, calcium-sensing, calcitonin and estrogen alpha receptors, insulin growth factor I, collagen type I alpha 1 chain and others. Despite this, the definite polymorphic marker has not been found in different populations which reflects the divergent results of association studies with their frequent limitations, and probably the fact that the relevant polymorphism is still awaiting identification. Once the genetic determinants can be defined, the clinical implications would be extensive both in diagnostics and in pharmacogenetics.
Zajickova
Katerina
K
Institute of Endocrinology, 116 94 Prague, Czech Republic. katka2222@volny.cz
Zofkova
Ivana
I
D000818:Animals; D000090602:Collagen Type I, alpha 1 Chain; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D020412:Multifactorial Inheritance / Q000235:genetics*; D010024:Osteoporosis / Q000235:genetics*
C000716127:COL1A1 protein, human; D000090602:Collagen Type I, alpha 1 Chain; D005819:Genetic Markers