title: Differential spectral interferometry: an imaging technique for biomedical applications.
abstract: Differential spectral interferometry (DSI), a novel method of biomedical imaging that combines the high dynamic range of optical coherence tomography (OCT) with inherently parallel low-bandwidth image acquisition of spectral interferometry (SI), is described. DSI efficiently removes the deleterious dc background inherent in SI measurements while maintaining the parallel nature of SI. We demonstrate DSI on both synthetic and biological samples. Because DSI preserves the low-bandwidth, parallel nature of SI, it is competitive with OCT for biomedical applications in terms of image quality and acquisition rate.
authors.affiliation: Southwest Sciences, Inc., 1570 Pacheco Street, Suite E-12, Santa Fe, New Mexico 87505, USA. avaktin@swsciences.com
authors.forename: Andrei B
authors.initials: AB
authors.lastname: Vakhtin
authors.forename: Kristen A
authors.initials: KA
authors.lastname: Peterson
authors.forename: William R
authors.initials: WR
authors.lastname: Wood
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Kane
mesh_terms: D019412:Anatomy, Cross-Sectional; D000818:Animals; D005583:Fourier Analysis; D007368:Interferometry; D007814:Larva / Q000033:anatomy & histology; D008027:Light; D008962:Models, Theoretical; D014982:Xenopus laevis / Q000254:growth & development