Aggressive angiomyxoma: an ultrastructural study of four cases.
The histogenesis of the aggressive angiomyxoma of the vulvo-vaginal region was studied. Four cases of aggressive angiomyxoma were examined by using light microscopy, electron microscopy, and immunohistochemistry. Myofibroblastic from smooth muscle cell differentiation was distinguished by paying close attention to the structures of the neoplastic cell membrane. Aggressive angiomyxomas exhibit subtle features of smooth muscle differentiation, suggesting that the neoplastic cells differentiate from a multipotent perivascular cell.
Martinez
Miguel A
MA
Departamento de Anatomia Patolgica, Hospital 12 de Octubre, Madrid, Spain. mmartinez.hdoc@salud.madrid.org
Ballestín
Claudio
C
Carabias
Esperanza
E
González Lois
Carmen
C
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic; D005260:Female; D005347:Fibroblasts / Q000737:chemistry / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D008875:Middle Aged; D032389:Myocytes, Smooth Muscle / Q000737:chemistry / Q000648:ultrastructure; D009232:Myxoma / Q000737:chemistry / Q000473:pathology*; D009363:Neoplasm Proteins / Q000032:analysis; D014625:Vaginal Neoplasms / Q000737:chemistry / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000737:chemistry / Q000473:pathology*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins