Double resection for patients with pancreatic cancer and a second primary renal cell cancer.
BACKGROUND
Reports of synchronous or metachronous double kidney-pancreas cancers are very rare.


METHODS
We present 2 patients with renal cell carcinoma and synchronous (1 patient) or metachronous (1 patient) primary pancreatic ductal adenocarcinoma. The patients underwent resection for both cancer types with a worthwhile outcome.


RESULTS
The appearance of different primaries in an individual may indicate a genetic predisposition to different neoplasms. The study of double primary cancers is important because it might provide understanding of a shared genetic basis of different solid tumors.


CONCLUSIONS
The association between these two cancers demands more detailed epidemiological and molecular investigation. From a clinical viewpoint a resectional policy is recommended.
Alexakis
N
N
Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, Liverpool, UK.
Bosonnet
L
L
Connor
S
S
Ellis
I
I
Sutton
R
R
Campbell
F
F
Hughes
M
M
Garvey
C
C
Neoptolemos
J P
JP
D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000601:surgery*; D016609:Neoplasms, Second Primary / Q000473:pathology / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery*