Modification of the functional capacity of sarcoplasmic reticulum membranes in patients suffering from chronic fatigue syndrome.
In chronic fatigue syndrome, several reported alterations may be related to specific oxidative modifications in muscle. Since sarcoplasmic reticulum membranes are the basic structures involved in excitation-contraction coupling and the thiol groups of Ca(2+) channels of SR terminal cisternae are specific targets for reactive oxygen species, it is possible that excitation-contraction coupling is involved in this pathology. We investigated the possibility that abnormalities in this compartment are involved in the pathogenesis of chronic fatigue syndrome and consequently responsible for characteristic fatigue. The data presented here support this hypothesis and indicate that the sarcolemmal conduction system and some aspects of Ca(2+) transport are negatively influenced in chronic fatigue syndrome. In fact, both deregulation of pump activities (Na(+)/K(+) and Ca(2+)-ATPase) and alteration in the opening status of ryanodine channels may result from increased membrane fluidity involving sarcoplasmic reticulum membranes.
Fulle
Stefania
S
Laboratorio Interuniversitario di Miologia, Università 'G. d'Annunzio', Nuovo Polo Didattico, 66013 Chieti Scalo, Italy. s.fulle@unich.it
Belia
Silvia
S
Vecchiet
Jacopo
J
Morabito
Caterina
C
Vecchiet
Leonardo
L
Fanò
Giorgio
G
D000328:Adult; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D015673:Fatigue Syndrome, Chronic / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008560:Membrane Fluidity; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D002118:Calcium