Maternal serum and amniotic fluid hydroxyproline levels in neural tube defects.
OBJECTIVE
The present study was aimed to evaluate the alterations of maternal serum and amniotic fluid OH- proline levels in neural tube defects (NTD).


METHODS
38 patients and 23 control subjects were selected from the patients followed up by the Departments of Genetics and Antenatal Care, Zekai Tahir Burak Women's Health, Education and Research Hospital. Amnion fluid and blood samples were synchronously obtained from NTD and control subjects. OH-proline levels were detected spectrophotometrically.


RESULTS
Amniotic fluid OH-proline levels were found to be increased in NTD patients compared to control subjects (p < 0.05). There was no statistically significant difference in serum OH-proline levels between the groups.


CONCLUSIONS
The results showed an increase in amniotic fluid OH-proline levels in NTD compared to the control group. It may be suggested that the increased OH-proline levels reflect increased collagen turnover in NTD patients. Indeed, amniotic fluid OH-proline levels may be a candidate as an additional diagnostic parameter in NTD.
Ozyurt
Hüseyin
H
Department of Biochemistry, Inönü University Medical Faculty, Malatya, Turkey. huseyinozyurt@hotmail.com
Totan
Aylin
A
Sahin
Semsettin
S
Kilinç
Cumhur
C
Söğüt
Sadik
S
Akyol
Omer
O
D000653:Amniotic Fluid / Q000378:metabolism*; D015415:Biomarkers; D003094:Collagen / Q000378:metabolism; D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D006909:Hydroxyproline / Q000097:blood*; D009436:Neural Tube Defects / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011446:Prospective Studies
D015415:Biomarkers; D003094:Collagen; D006909:Hydroxyproline