Non-occlusive mesenteric ischemia and its associated intestinal gangrene in acute pancreatitis.
OBJECTIVE
Non-occlusive mesenteric ischemia (NOMI) has been defined as diffuse intestinal ischemia that often results in intestinal gangrene in the presence of a patent arterial trunk. The prevalence and nature of NOMI in acute pancreatitis was investigated.


METHODS
A total of 120 consecutive patients with acute pancreatitis managed in the Department of Surgery II, Kumamoto University Medical School, from April 1992 through December 2002, were investigated retrospectively. Among them, 60 patients had the severe form.


RESULTS
The overall mortality of acute pancreatitis patients was 8.3% (10/120). The prevalence and mortality of acute pancreatitis associated with NOMI were 6.7% (8/120) and 63% (5/8), respectively, while those of patients with NOMI-associated intestinal gangrene were 4.2% (5/120) and 100% (5/5), respectively. The mortality of patients with severe acute pancreatitis who did not develop NOMI was 10% (5/52). All patients with NOMI-associated intestinal gangrene quickly progressed and subsequently died of multiple organ failure. Plasma creatine phosphokinase (CPK) and lactate levels were elevated significantly in patients with NOMI.


CONCLUSIONS
Acute pancreatitis associated with NOMI was extremely severe. If the plasma CPK and lactate levels are extremely high, NOMI should be suspected.
Hirota
Masahiko
M
Department of Surgery II, Kumamoto University Medical School, Kumamoto City, Kumamoto, Japan.
Inoue
Kotaro
K
Kimura
Yu
Y
Mizumoto
Takao
T
Kuwata
Kinumo
K
Ohmuraya
Masaki
M
Ishiko
Takatoshi
T
Beppu
Toru
T
Ogawa
Michio
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D002648:Child; D002675:Child, Preschool; D005260:Female; D005734:Gangrene / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D007410:Intestinal Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D007511:Ischemia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000000981:diagnostic imaging / Q000473:pathology; D010186:Pancreatic Function Tests; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications* / Q000000981:diagnostic imaging / Q000401:mortality; D011169:Portal Vein / Q000000981:diagnostic imaging; D013152:Splanchnic Circulation / Q000502:physiology*; D014057:Tomography, X-Ray Computed