title: Application of a two-stage temperature control strategy for enhanced glutathione production in the batch fermentation by Candida utilis.
abstract: In batch culture for glutathione production with Candida utilis, a higher temperature (30 degrees C) was required to hasten cell growth while a lower temperature (26 degrees C) was needed to increase the production of glutathione. A two-stage temperature control strategy was used to enhance both the yield and the productivity of glutathione. As a result, glutathione production was increased by 5% and 23% of that at 26 degrees C and 30 degrees C, respectively, and the intracellular glutathione content reached 2.5% (w/w).
authors.affiliation: Key Laboratory of Industrial Biotechnology, Ministry of Education, Southern Yangtze University, Wuxi 214036, P.R. China.
authors.forename: Gongyuan
authors.initials: G
authors.lastname: Wei
authors.forename: Yin
authors.initials: Y
authors.lastname: Li
authors.forename: Guocheng
authors.initials: G
authors.lastname: Du
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
mesh_terms: D019149:Bioreactors / Q000382:microbiology*; D002175:Candida / Q000145:classification / Q000201:enzymology* / Q000254:growth & development; D005246:Feedback; D005947:Glucose / Q000378:metabolism*; D005978:Glutathione / Q000096:biosynthesis*; D011786:Quality Control; D012680:Sensitivity and Specificity; D013045:Species Specificity; D013696:Temperature
chemical_list: D005978:Glutathione; D005947:Glucose