Activity of chemotherapy with carboplatin plus paclitaxel in a recurrent mesonephric adenocarcinoma of the uterine corpus.
BACKGROUND
Malignant lesions derived from mesonephric (Wolffian) remnants are uncommon. The course of these tumors is usually indolent, and the recurrence has only been documented in nine cases. Because of the small number of cases, no current recommendations exist regarding treatment, and little is known about the response to chemotherapeutic agents.


METHODS
A 33-year-old woman was diagnosed with a mesonephric adenocarcinoma arising in the uterine corpus. Ten months after initial surgery and radiotherapy she presented with local and pulmonary relapse. Salvage chemotherapy with carboplatin plus paclitaxel was administered with a good response.


CONCLUSIONS
Mesonephric adenocarcinomas are uncommon neoplasms. Their treatment remains elusive. We report a case of a recurrent uterine mesonephric adenocarcinoma that presented a good response to therapy with carboplatin plus paclitaxel. A review of the previous literature is also presented.
Montagut
Clara
C
Department of Medical Oncology, Institute of Oncology and Haematology, University of Barcelona, Hospital Clinic, Barcelona, Spain.
Mármol
Maribel
M
Rey
Victoria
V
Ordi
Jaume
J
Pahissa
Jaume
J
Rovirosa
Angeles
A
Gascón
Pedro
P
Mellado
Begoña
B
D000230:Adenocarcinoma / Q000188:drug therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008649:Mesonephroma / Q000188:drug therapy*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage; D014594:Uterine Neoplasms / Q000188:drug therapy*
D016190:Carboplatin; D017239:Paclitaxel