Fatal disseminated Acremonium strictum infection in a preterm newborn: a very rare cause of neonatal septicaemia.
Species of the genus Acremonium (Cephalosporium) are opportunistic micro-organisms that are environmentally widespread saprophytes in soil and can, very rarely, be pathogenic in humans. Disseminated infection has been described in patients with immunodeficiency, but has previously been reported in only one neonate. A preterm infant with Acremonium strictum fungaemia is reported here. The patient was born at 27 weeks gestation and weighed 870 g at birth. She needed intensive respiratory management and became septic on day 11 of life. Blood and cerebrospinal fluid (CSF) cultures were positive for A. strictum. The patient did not respond to therapy with amphotericin B plus fluconazole and died on day 25 of life. The autopsy showed foci due to A. strictum in the brain, liver and heart.
Yalaz
Mehmet
M
Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
Hilmioglu
Suleyha
S
Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
Metin
Dilek
D
Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
Akisu
Mete
M
Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
Nart
Deniz
D
Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
Cetin
Hasan
H
Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
Ozturk
Cengiz
C
Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
Isik
Ecmel
E
Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
Kultursay
Nilgun
N
Division of Neonatology, Department of Pediatrics1, Department of Microbiology and Clinical Microbiology2 and Department of Pathology3, Ege University Faculty of Medicine, Izmir, Turkey.
D000164:Acremonium / Q000302:isolation & purification*; D017809:Fatal Outcome; D005260:Female; D016469:Fungemia / Q000382:microbiology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D009181:Mycoses / Q000382:microbiology*