[New thrombophilia markers in digestive tract neoplasia].
Haemostatic system compounds not routinely studied, have been evaluated to define the individual risk of VTE (venous thromboembolism) and to influence the prognosis using selective drugs. Significantly high values of fibrinogen, free-TFPI, F1 + 2 fragments and TAT complexes on coagulation side and PAI-1 and TAFI on fibrinolysis side have been detected. Thrombin seems to have a role in the inhibition of TAFI dependent fibrinolysis not inhibited by heparin.
Parisi
V
V
Unità Operativa Complessa di Chirurgia Oncologica C, Istituto Nazionale Tumori Fondazione Pascale, Napoli.
Capasso
F
F
Pudore
L
L
Torre
S
S
Russo
V
V
Vitale
S
S
Delrio
P
P
Palaia
R
R
Ruffolo
F
F
Papa
M L
ML
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D025901:Carboxypeptidase B2 / Q000097:blood; D004067:Digestive System Neoplasms / Q000097:blood / Q000150:complications*; D029968:Escherichia coli Proteins / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008297:Male; D026901:Membrane Transport Proteins / Q000097:blood; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011237:Predictive Value of Tests; D011379:Prognosis; D011516:Prothrombin; D012306:Risk; D019851:Thrombophilia / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology
D015415:Biomarkers; D029968:Escherichia coli Proteins; D008074:Lipoproteins; D026901:Membrane Transport Proteins; D010446:Peptide Fragments; D017395:Plasminogen Activator Inhibitor 1; C051928:lipoprotein-associated coagulation inhibitor; C045879:prothrombin fragment 1.2; C408585:twin-arginine translocase complex, E coli; D011516:Prothrombin; D005340:Fibrinogen; D006493:Heparin; D025901:Carboxypeptidase B2