General and efficient synthesis of arylamino- and alkylamino-substituted diphenylporphyrins and tetraphenylporphyrins via palladium-catalyzed multiple amination reactions.
A series of arylamino- and alkylamino-substituted diphenylporphyrins and tetraphenylporphyrins were efficiently synthesized by reactions of brominated porphyrin precursors with amines via palladium-catalyzed amination. The multiple amination reactions are general and suitable for a variety of amines, affording the desired aminoporphyrins in good to excellent yields. Examples include aromatic and aliphatic amines, primary and secondary amines, electron-rich, -neutral, and -poor amines as well as heteroaromatic amines and imines.
Gao
Guangyao Y
GY
Department of Chemistry, University of Tennessee, Knoxville, Tennessee 37996-1600, USA.
Chen
Ying
Y
Zhang
X Peter
XP