title: Synthesis of micron diameter polybutadiene-encapsulated non-porous zirconia particles for ultrahigh pressure liquid chromatography.
abstract: In this study, 1-microm diameter polybutadiene-encapsulated non-porous zirconia particles were synthesized, slurry packed into 50-microm I.D. fused-silica capillary columns, and evaluated using ultrahigh pressure liquid chromatography. The dependencies of column efficiency and solute retention factor on pressure were investigated. Efficiencies as high as 280000 plates per meter were obtained for the separation of anti-inflammatory drugs at a pressure of 1351 MPa. Comparing the reversed-phase behavior of the polybutadiene-encapsulated non-porous zirconia with octadecylsilane bonded non-porous silica, greater selectivity was found using the zirconia-based material for the applications reported in this study. The encapsulated non-porous zirconia particles demonstrated excellent thermal stability in the separation of polycyclic aromatic hydrocarbons at a temperature of 100 degrees C and a pressure of 1351 MPa.
authors.affiliation: Department of Chemistry and Biochemistry, C267 Benson Science Building, Brigham Young University, P.O. Box 25700, Provo, UT 84602-5700, USA.
authors.forename: Yanqiao
authors.initials: Y
authors.lastname: Xiang
authors.forename: Bingwen
authors.initials: B
authors.lastname: Yan
authors.forename: Clayton V
authors.initials: CV
authors.lastname: McNeff
authors.forename: Peter W
authors.initials: PW
authors.lastname: Carr
authors.forename: Milton L
authors.initials: ML
authors.lastname: Lee
mesh_terms: D000893:Anti-Inflammatory Agents / Q000302:isolation & purification*; D002070:Butadienes / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D020724:Elastomers; D006358:Hot Temperature; D011108:Polymers / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D002070:Butadienes; D020724:Elastomers; D011108:Polymers; C028834:polybutadiene; D015040:Zirconium; C028541:zirconium oxide