Gene amplification and splice variants of 25-hydroxyvitamin D3 1,alpha-hydroxylase (CYP27B1) in glioblastoma multiforme--a possible role in tumor progression?
We report a gene amplification of 25-hydroxyvitamin D3 1,alpha-hydroxylase and the appearance of various splice variants in glioblastoma multiforme. Some protein products of the widespread expressed variants may exert a biological function. The analysis of amplification and overexpression of alternative transcripts will provide new insights in the regulation of the 25-hydroxyvitamin D3 1,alpha-hydroxylase expression and may have implications for prognosis in glioblastoma.
Diesel
Britta
B
Universität des Saarlandes, Kirrberger Strasse, Geb. 60, 66421 Homburg/Saar, Germany.
Fischer
Ulrike
U
Meese
Eckart
E
D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000235:genetics* / Q000378:metabolism; D017398:Alternative Splicing; D001932:Brain Neoplasms / Q000201:enzymology / Q000378:metabolism; D005784:Gene Amplification; D005909:Glioblastoma / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D006801:Humans
D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase