[Effect of bifolar and chlofiden on DNA synthesis of sarcoma 45 cells and on mitotic activity of rat small intestine epithelium].
Results of the study on the influence of new antitumor preparations chlofiden and bifolar on sarcoma 45 DNA synthesis and on mitotic activity are given. It was shown that bifolar and chlofiden led to inhibition of label incorporation into DNA (3H-thymidine). Inhibition of mitotic activity after injection of both preparations in toxic doses (DL50) was revealed. During injection of the bifolar functional character of changes was established that is mitotic activity of the preparation during injection was restored.
Sharykina
N I
NI
Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv.
Kudriavtseva
I G
IG
Pavlovskaia
G P
GP
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D007928:Lethal Dose 50; D008938:Mitosis / Q000187:drug effects*; D051381:Rats; D012509:Sarcoma / Q000235:genetics*
D000970:Antineoplastic Agents; D004247:DNA