Traveling stripes on the skin of a mutant mouse.
In the course of animal development, complex structures form autonomously from the apparently shapeless egg. How cells can produce spatial patterns that are much larger than each cell is one of the key issues in developmental biology. It has been suggested that spatial patterns in animals form through the same principles by which dispatched structures are formed in the nonbiological system. However, because of the complexity of biological systems, molecular details of such phenomena have been rarely clarified. In this article, we introduce an example of a pattern-forming phenomenon that occurs in the skin of mutant mice. The mutant mouse has a defect in splicing of the Foxn1 (Whn or nude) gene, which terminates hair follicle development just after pigment begins to accumulate in the follicle. The immature follicles are rapidly discharged, and a new hair cycle resumes. Eventually, the skin color of the mouse appears to oscillate. The color oscillation is synchronous in juvenile mice, but the phase gradually shifts among skin regions to eventually form traveling, evenly spaced stripes. Although the time scale is quite different, the pattern change in the mutant mouse shares characteristics with the nonlinear waves generated on excitable media, such as the Belousov-Zhabotinskii reaction, suggesting that a common principle underlies the wave pattern formation. Molecular details that underlie the phenomenon can be conjectured from recent molecular studies.
Suzuki
Noboru
N
Institute for Laboratory Animals, Medical School of Mie University, Uehama 1515, Tsu 514-8507, Japan.
Hirata
Masashi
M
Kondo
Shigeru
S
D000367:Age Factors; D017398:Alternative Splicing; D000818:Animals; D019521:Body Patterning / Q000235:genetics / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D051858:Forkhead Transcription Factors; D006197:Hair / Q000254:growth & development; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D008819:Mice, Nude; D008954:Models, Biological; D010641:Phenotype; D012867:Skin / Q000254:growth & development; D012880:Skin Pigmentation / Q000235:genetics* / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; D014157:Transcription Factors; C090140:Whn protein