Iron absorption from fish sauce and soy sauce fortified with sodium iron EDTA.
BACKGROUND
Fish sauce and soy sauce have been suggested as food vehicles for iron fortification in Asia. NaFeEDTA is a potentially useful fortificant because it can be added to these condiments without causing precipitation during storage.


OBJECTIVE
The objectives were to evaluate iron absorption from NaFeEDTA-fortified fish sauce and soy sauce against a reference fortificant (FeSO(4)), to compare iron absorption from NaFeEDTA-fortified fish sauce and soy sauce, and to evaluate the influence of fish sauce and soy sauce per se on iron absorption.


METHODS
Five separate iron-absorption studies were made in adult women (10 women per study). Iron absorption was measured on the basis of erythrocyte incorporation of (57)Fe or (58)Fe 14 d after the intake of labeled meals of rice or rice and vegetables. Fish sauce or soy sauce (10 g) fortified with 5 mg Fe as NaFeEDTA or FeSO(4) was fed with selected meals. The results are presented as geometric means.


RESULTS
Iron absorption from NaFeEDTA- and FeSO(4)-fortified fish sauce (3.3% and 3.1%, respectively) and soy sauce (6.1% and 5.6%, respectively) was not significantly different. No significant difference was observed when NaFeEDTA-fortified fish sauce and soy sauce were compared directly (6.7% and 7.9%, respectively). Soy sauce inhibited iron absorption from rice-based meals (8.5% without and 6.0% with soy sauce; P < 0.02), whereas fish sauce did not affect iron absorption significantly.


CONCLUSIONS
The relatively high iron absorption from NaFeEDTA-fortified fish sauce and soy sauce and the acceptable organoleptic properties of NaFeEDTA indicate the potential usefulness of this iron fortificant in fish sauce and soy sauce fortification programs.
Fidler
Meredith C
MC
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zurich, Switzerland.
Davidsson
Lena
L
Walczyk
Thomas
T
Hurrell
Richard F
RF
D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000378:metabolism; D001682:Biological Availability; D003676:Deferoxamine; D004032:Diet; D004492:Edetic Acid / Q000627:therapeutic use*; D005260:Female; D005290:Ferric Compounds / Q000627:therapeutic use*; D005293:Ferritins / Q000378:metabolism; D005395:Fish Oils / Q000627:therapeutic use*; D005527:Food, Fortified; D006801:Humans; D007408:Intestinal Absorption; D007503:Iron Isotopes; D019266:Iron, Dietary / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009752:Nutritional Status; D010833:Phytic Acid; D013025:Glycine max
D005290:Ferric Compounds; D005395:Fish Oils; D007503:Iron Isotopes; D019266:Iron, Dietary; D010833:Phytic Acid; D005293:Ferritins; D004492:Edetic Acid; D003676:Deferoxamine; C019179:Fe(III)-EDTA