[Albumin kinetics in patients with severe sepsis].
OBJECTIVE
To explore the mechanism of hypoalbuminemia in patients with severe sepsis.


METHODS
I(125)-labeled albumin was administered intravenously to 10 health volunteers and 10 patients with severe sepsis. Blood samples were taken at 0, 1, 2, 4, 8, 12, 24 hours and 2, 3, 4, 5, 6, 7, 9, 11, 13, 15, 18, 22, 25 days for the measurement of the dose of gamma-radiation and the curve of concentration and time. Then the half-life time (t(1/2)), apparent volume of distribution (V(d)) and transportation rate (K(12)) from center compartment to side compartment of albumin were calculated.


RESULTS
The half-life time in septic group was obviously shorter than that in control group (8.2 +/- 1.4 vs. 12.5 +/- 1.7, P < 0.01). The transportation rate in the septic group was higher than that in the control group [(4.4 +/- 1.9) x 10(-2)/h vs. (2.4 +/- 0.6) x 10(-2)/h, P < 0.05]. There was no significant difference in apparent volume of distribution between the two groups.


CONCLUSIONS
In patients with severe sepsis, the distribution rate of albumin from vessel to tissue was obviously increased and the decomposition rate of albumin was markedly improved.
Li
Wei-qin
WQ
Research Institute of General Surgery, Nanjing General Hospital of People's Liberation Army, Nanjing 210002, China.
Wang
Xin-ying
XY
Zhu
Hong
H
Tan
Heng-shan
HS
Rui
Jian-zhong
JZ
Bao
Yang
Y
Quan
Zhu-fu
ZF
Li
Ning
N
Li
Jie-shou
JS
D000328:Adult; D000368:Aged; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*
D012709:Serum Albumin