Characterization of mapacalcine-sensitive Ca(2+) channels in rat kidney.
Mapacalcine receptors have been found to be associated with a Ca(2+) permeability insensitive to all known calcium blockers. Recently, high densities of mapacalcine receptors have been detected in the choroid plexus of rat brain. To determine a possible role for these channels, we have investigated their presence on other structures which, like choroid plexus, are involved in the secretion of biological fluids. Our data demonstrate that there are specific mapacalcine receptors on kidney membranes and glomeruli preparations. The mapacalcine receptors were present in all structures of the kidney. However, autoradiographic data demonstrated that superficial part of the cortex was more labeled than the other part of the kidney. These data would suggest that mapacalcine receptors could play a role in calcium homeostasis.
Mourre
C
C
Neurobiologie Intégrative et Adaptative, CNRS-UMR 6149, Faculté des Sciences, Université de Provence, avenue Escadrille Normandie-Niemen, Marseille, France.
Lazou
B
B
Cambar
J
J
Neuilly
G
G
Hugues
M
M
D000311:Adrenal Glands / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D002121:Calcium Channel Blockers / Q000378:metabolism*; D015220:Calcium Channels / Q000032:analysis*; D002462:Cell Membrane / Q000378:metabolism; D007668:Kidney / Q000033:anatomy & histology / Q000737:chemistry* / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism; D007700:Kinetics; D008297:Male; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D011506:Proteins; C106560:mapacalcine