Conditional gene targeting.
Precise chromosomal alterations can be made in restricted tissues at chosen times in the living experimental animal. The engineering of such conditional systems has been successfully tackled in transgenic mice during the last decade. This review focuses on how several different genetic regulatory elements from lower organisms can be applied in combination to achieve this goal.
Lindeberg
Jonas
J
Developmental Biology Unit, Department of Neuroscience, Uppsala University, Biomedical Center, Sweden. jonas.lindeberg@nln.dll.se
D000818:Animals; D018390:Gene Targeting; D051379:Mice