title: High-frequency oscillatory ventilation in adult acute respiratory distress syndrome.
abstract: OBJECTIVE
  This study examined whether ARDS patients in whom predefined ventilator settings fail to maintain oxygenation and CO2 removal can be safely transitioned to high-frequency oscillatory ventilation (HFOV), and whether HFOV use is efficacious.
  
  
  METHODS
  Prospective observational study in the 14-bed intensive care unit of a university hospital.
  
  
  METHODS
  42 patients with ARDS (APACHE II score 28 (IQR 24-37) and ventilation time prior HFOV 3.0 days (0.7-9.1).
  
  
  RESULTS
  Gas exchange parameters and ventilator data were recorded before and during HFOV treatment (-12 h, -6 h, baseline, 10 min, 1 h, 6 h, 12 h, 24 h). Primary endpoints included: (a) PaO2/FIO2 ratio 24 h after start of HFOV treatment or the last point of measurement if HFOV ended within the first 24 h; (b) HFOV-related complications. Post hoc analysis assessed the relationship between outcome and the response to HFOV, and between outcome and time of mechanical ventilation prior to HFOV. At baseline the median PaO2/FIO2 ratio was 95 (IQR 62-129); after 24 h of HFOV the PaO2/FIO2 ratio had increased significantly to 165 (88-225); only one patient developed a unilateral pneumothorax. Of the 42 patients 18 (43%) had died by day 30. Subset analyses showed a significantly higher 30-day mortality rate in patients with at least 3 days of mechanical ventilation prior to HFOV (64%) and in patients without oxygenation improvement after 24 h on HFOV (71%).
  
  
  CONCLUSIONS
  HFOV is an effective and safe method to ventilate ARDS patients. Failure to improve oxygenation within 24 h of HFOV is associated with high mortality.
authors.affiliation: Department of Anesthesiology, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: David
authors.forename: Norbert
authors.initials: N
authors.lastname: Weiler
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Heinrichs
authors.forename: Markus
authors.initials: M
authors.lastname: Neumann
authors.forename: Thilo
authors.initials: T
authors.lastname: Joost
authors.forename: Klaus
authors.initials: K
authors.lastname: Markstaller
authors.forename: Balthasar
authors.initials: B
authors.lastname: Eberle
mesh_terms: D000328:Adult; D005260:Female; D006612:High-Frequency Ventilation / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage; D011446:Prospective Studies; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D013997:Time Factors
chemical_list: D010100:Oxygen