Glucosides from Vitex agnus-castus.
The methanolic extract of the flowering stems of Vitex agnus-castus yielded three new iridoids: 6'-O-foliamenthoylmussaenosidic acid (agnucastoside A), 6'-O-(6,7-dihydrofoliamenthoyl)mussaenosidic acid (agnucastoside B) and 7-O-trans-p-coumaroyl-6'-O-trans-caffeoyl-8-epiloganic acid (agnucastoside C) in addition to four known iridoids (aucubin, agnuside, mussaenosidic acid and 6'-O-p-hydroxybenzoylmussaenosidic acid) and one known phenylbutanone glucoside (myzodendrone). The structure elucidations were mainly done by spectroscopic methods (1D and 2D NMR spectra) and MS data interpretation. The purified compounds were tested for biological activities against various microorganisms and cancer cell lines.
Kuruüzüm-Uz
Ayşe
A
Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy, TR-06100 Ankara, Turkey. ayseuz@hacettepe.edu.tr
Ströch
Karsten
K
Demirezer
L Omür
LO
Zeeck
Axel
A
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D039823:Iridoids / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D018547:Plant Stems / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013211:Staphylococcus aureus / Q000187:drug effects; D014407:Tumor Cells, Cultured; D020950:Vitex / Q000737:chemistry*
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D006027:Glycosides; D039823:Iridoids