title: The effect of left ventricular diastolic dysfunction on the pathogenesis of angina decubitus.
abstract: OBJECTIVE
  To investigate the effect of left ventricular diastolic dysfunction on the pathogenesis of angina decubitus (AD).
  
  
  METHODS
  The study population consisted of three groups: 20 individuals without cardiovascular studied as group I. Group II included 20 patents with coronary artery disease and without AD. Thirty-one patients with AD and ejection fraction (EF) > 50% were studied as group III. Group II and III were matched for age, EF and extent of coronary artery disease.
  
  
  RESULTS
  Left ventriculography (LVG) showed that left ventricular (LV) first 1/3 filling fraction (1/3FF) was significantly lower in group III than in group II and I (both P < 0.001), but LV late 1/3 FF was much higher in group III than in group II and I (P < 0.05, P < 0.01). Left ventricular end-diastolic pressure (LVEDP) was markedly increased before and after LVG in group II and III as compared with group I (both P < 0.05, both P < 0.001). The difference of LVEDP caused by left atrial contraction (left atrial contraction pressure difference, LACPD) before and after LVG was much higher in group III than in group I ( P < 0.01, P < 0.001). However, there we significant differences in LVEDP and in LACPD between before and after LVG only in group III (both P < 0.01).
  
  
  CONCLUSIONS
  The patients with AD have LV diastolic dysfunction, which may be closely related to the pathogenesis of angina decubitus.
authors.affiliation: Cardiovascular Institute and Fu Wai Hospital, CAMS & PUMC, Beijing 100037.
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: R
authors.initials: R
authors.lastname: Gao
authors.forename: K
authors.initials: K
authors.lastname: Yao
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: X
authors.initials: X
authors.lastname: Qin
authors.forename: S
authors.initials: S
authors.lastname: Qiao
authors.forename: M
authors.initials: M
authors.lastname: Yao
mesh_terms: D000328:Adult; D000368:Aged; D000788:Angina Pectoris, Variant / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D001794:Blood Pressure; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology; D003971:Diastole / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*