title: Type II transmembrane serine proteases.
abstract: The recent availability of human and mouse genome sequences and expressed sequence tag databases facilitated the identification of a large new family of membrane anchored serine proteases, the type II transmembrane serine proteases or TTSPs. Analyses of human inherited disorders and gene targeting studies in mice have revealed that several members of this new protease family have critical functions in development and health. Preliminary studies also suggest that aberrant expression of type II transmembrane serine proteases may be linked to disease progression. The knowledge gathered thus far of the genetics, physiology, and pathology of this interesting new serine protease family will be reviewed here in brief.
authors.affiliation: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Roman
authors.initials: R
authors.lastname: Szabo
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Wu
authors.forename: Robert B
authors.initials: RB
authors.lastname: Dickson
authors.forename: Sarah
authors.initials: S
authors.lastname: Netzel-Arnett
authors.forename: Toni M
authors.initials: TM
authors.lastname: Antalis
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Bugge
mesh_terms: D000818:Animals; D018450:Disease Progression; D006128:Growth / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D012697:Serine Endopeptidases / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
chemical_list: D007527:Isoenzymes; D012697:Serine Endopeptidases