title: Immunocytochemical examinations of hippocampal nerve cells after experimental administration of dexamethasone.
abstract: The purpose of this research was an assessment of MAP2 immunoreactivity in hippocampal neurons after administration of toxic doses of dexamethasone. Experiments were led on Albino-Swiss mouse males. The obtained results indicate that dexamethasone causes significant decrease of MAP2 immunoreactivity in hippocampal nerve cells of the CA3 region. Our results show damage of neuronal cytoskeleton in this area of the brain.
authors.affiliation: Department of Histology and Embryology with the Lab of Experimental Cytology, Department of Clinical Pharmacology, Medical University of Lublin.
authors.forename: Joanna
authors.initials: J
authors.lastname: Sekita-Krzak
authors.forename: Krystyna
authors.initials: K
authors.lastname: Czerny
authors.forename: Iwona
authors.initials: I
authors.lastname: Zebrowska-Łupina
authors.forename: Maria
authors.initials: M
authors.lastname: Stepniewska
authors.forename: Józef
authors.initials: J
authors.lastname: Visconti
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Pedrycz-Wieczorska
mesh_terms: D000818:Animals; D003907:Dexamethasone / Q000008:administration & dosage* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D009410:Nerve Degeneration / Q000139:chemically induced* / Q000378:metabolism* / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D017966:Pyramidal Cells / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D012016:Reference Values
chemical_list: D008869:Microtubule-Associated Proteins; D018696:Neuroprotective Agents; D003907:Dexamethasone