Electrophysiological analysis of visual function in mutant mice.
The mouse has become a key animal model for ocular research. This situation reflects the fact that genes implicated in human retinal disorders or in mammalian retinal function may be readily manipulated in the mouse. Visual electrophysiology provides a means to examine retinal function in mutant mice, and stimulation and recording protocols have been developed that allow the activity of many classes of retinal neurons to be examined and which take into account unique features of the mouse retina. Here, we review the mouse visual electrophysiology literature, covering techniques used to record the mouse electroretinogram and visual evoked potential, and how these have been applied to characterize the functional implications of gene mutation or manipulation in the mouse retina.
Peachey
Neal S
NS
Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. peachen@ccf.org
Ball
Sherry L
SL
D000818:Animals; D004195:Disease Models, Animal; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005818:Genetic Engineering; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D009410:Nerve Degeneration / Q000235:genetics; D010786:Photoreceptor Cells; D012162:Retinal Degeneration / Q000235:genetics; D012164:Retinal Diseases / Q000235:genetics; D014785:Vision, Ocular / Q000502:physiology*