title: Molluscicidal activity of Physalis angulata L. extracts and fractions on Biomphalaria tenagophila (d'Orbigny, 1835) under laboratory conditions.
abstract: The main objective of this research is to evaluate the molluscicide activity of Physalis angulata L. Biomphalaria tenagophila specimens under laboratory conditions. Extracts and fractions were supplied by the Laborat rio de Qu mica de Produtos Naturais, Farmanguinhos-Fiocruz. Experiments were performed according to the methodology described by the World Health Organization for molluscicide tests using the concentrations from 0.1 to 500 mg/l of the extracts, fractions and of a pool of physalins modified steroids present in this species. The results show that ethyl acetate and acetone extracts from the whole plant, the ethanolic extracts of the roots and the physalins pool from stems and leaves were active. Only the whole plant extracts were available in sufficient quantity for the determination of LD50 and LD90 values.
authors.affiliation: Núcleo de Biologia e Controle de Endo e Ectoparasita de Interesse Médico e Veterinário, Departamento de Biologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, 21045-900, Brasil. santosja@ioc.fiocruz.br
authors.forename: José Augusto A
authors.initials: JA
authors.lastname: dos Santos
authors.forename: Therezinha Coelho B
authors.initials: TC
authors.lastname: Tomassini
authors.forename: Deise Cristina Drummond
authors.initials: DC
authors.lastname: Xavier
authors.forename: Ivone Maria
authors.initials: IM
authors.lastname: Ribeiro
authors.forename: Melissa Teixeira G
authors.initials: MT
authors.lastname: da Silva
authors.forename: Zenildo Buarque
authors.initials: ZB
authors.lastname: de Morais Filho
mesh_terms: D000818:Animals; D001700:Biomphalaria / Q000187:drug effects*; D007928:Lethal Dose 50; D008975:Molluscacides / Q000494:pharmacology*; D032321:Physalis / Q000737:chemistry*; D010936:Plant Extracts / Q000145:classification / Q000494:pharmacology
chemical_list: D008975:Molluscacides; D010936:Plant Extracts