[Synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol].
OBJECTIVE
To study the synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol.


METHODS
Pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol were synthesized primarily from 2-methyl-5-nitroimidazol, norfloxacin, ciprofloxacin, enoxacin via nucleophilic substitution and esterification. The antibacterial activity of the nine target compounds were tested.


RESULTS
Nine new compounds were synthesized (IIa-c and IIIa-f). The structure of the title compounds were identified by 1HNMR, MS as well as elementary analysis.


CONCLUSIONS
Compounds IIa, IIb and IIc showed antibacterial activity, and were worth further studying.
Ye
Fa-qing
FQ
Department of Chemistry, Wenzhou Medical College, Wenzhou 325027, China. YZYFQ-mail@sina.com
Chen
Li
L
Huang
Jin-min
JM
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002939:Ciprofloxacin / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D015365:Enoxacin / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009593:Nitroimidazoles / Q000737:chemistry*; D009643:Norfloxacin / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
D000890:Anti-Infective Agents; D009593:Nitroimidazoles; C052586:2-methyl-5-nitroimidazole; D015365:Enoxacin; D002939:Ciprofloxacin; D009643:Norfloxacin