title: [Microcirculation in hypertension].
abstract: Changes of microcirculatory vascular bed play important role in pathogenesis of essential hypertension. All components of the system of microcirculation including vessels and circulating blood are involved into pathological process. Resistance to blood flow is mostly formed in this system. Resistance depends on length, diameter of microvessels and viscosity of blood. In the process of the disease development the following signs of remodeling at the level of microcirculation emerge: decrease of density of vasculature, modification of the media/lumen ratio, increase of blood viscosity, slowing of angiogenesis, impairment of endothelial function. These phenomena can be both cause and consequence of hypertensive disease. Their heterogeneity depends on a variety of factors (duration, stage of the disease, etc.). It seems feasible to differentiate therapy in accordance with character and severity of changes in the system of microcirculation.
authors.forename: V I
authors.initials: VI
authors.lastname: Makolkin
authors.forename: V I
authors.initials: VI
authors.lastname: Podzolkov
authors.forename: V I
authors.initials: VI
authors.lastname: Pavlov
authors.forename: V V
authors.initials: VV
authors.lastname: Samoĭlenko
mesh_terms: D000818:Animals; D001160:Arterioles / Q000502:physiology / Q000503:physiopathology; D001809:Blood Viscosity; D002196:Capillaries / Q000502:physiology; D002200:Capillary Resistance; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation; D018919:Neovascularization, Physiologic; D051381:Rats; D013997:Time Factors; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology; D014699:Venules / Q000502:physiology / Q000503:physiopathology
chemical_list: D042461:Vascular Endothelial Growth Factor A