Synthesis of amide compounds of ferulic acid, and their stimulatory effects on insulin secretion in vitro.
We prepared amide compounds which were derived from ferulic acid using various amines, and investigated their stimulatory effects on insulin secretion using rat pancreatic RIN-5F cells. Most of these compounds exhibited significant promotion of the insulin-release at a concentration of 10 microM and in particular, the amides having n-butyl, n-pentyl, pyrrolidine, and piperidine groups showed high activity.
Nomura
Eisaku
E
Industrial Technology Center of Wakayama Prefecture, 60 Ogura, 649-6261, Wakayama, Japan. nomura@wakayama-kg.go.jp
Kashiwada
Ayumi
A
Hosoda
Asao
A
Nakamura
Kozo
K
Morishita
Hideko
H
Tsuno
Takuo
T
Taniguchi
Hisaji
H
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D002470:Cell Survival; D003373:Coumaric Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007328:Insulin / Q000096:biosynthesis*; D051381:Rats
D000577:Amides; D003373:Coumaric Acids; D007328:Insulin; C004999:ferulic acid