Investigation of DNA strand exchange mechanisms mediated by cationic polymers.
It was observed that conjugation of dextran for PLL provided PLL-g-Dex with new properties of enhancing and accelerating inter-nucleotide recognition (1, 2, 3). In this paper, we report the effects of cationic PLL-g-Dex copolymers on base-pair formation of self-complementary octamer oligonucleotide by using NMR and CD analysis. NMR studies revealed that PLL-g-Dex copolymer did not affect hydrogen-bondings between bases in DNA duplex. CD studies also supported inert nature of the copolymer upon hybrid structure.
Sato
Yuichi
Y
Precursory Research for Embryonic Science and Technology, Japan Science and Technology Corporation, 4-1-8 Honcho, Kawaguti, Saitama 332-0012, Japan.
Kim
Won Jong
WJ
Choi
Sung Won
SW
Saito
Minako
M
Kano
Arihiro
A
Akaike
Toshihiro
T
Maruyama
Atsushi
A
D001483:Base Sequence; D002412:Cations; D004247:DNA / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
D002412:Cations; D011108:Polymers; D004247:DNA