Magnetic resonance imaging and spectroscopy in a patient with treated methylmalonic acidemia.
Magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (proton MRS) findings before and after carnitine therapy in a patient with methylmalonic acidemia (MMA) are evaluated. The hyperintensity on T2-weighted image and diffusion-weighted image and the decreased apparent diffusion coefficient of bilateral basal ganglia were normalized in parallel with normalization of the elevated lactate levels and the decreased N-acetyl-aspartate levels, corresponding to improvement of clinical symptoms. MRI and proton MRS may serve as a suitable, noninvasive modality for monitoring treated MMA.
Takeuchi
Mayumi
M
Department of Radiology, University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima, Japan. mayumi@clin.med.tokushima-u.ac.jp
Harada
Masafumi
M
Matsuzaki
Kenji
K
Hisaoka
Sonoka
S
Nishitani
Hiromu
H
Mori
Kenji
K
D001479:Basal Ganglia / Q000473:pathology*; D020739:Brain Diseases, Metabolic, Inborn / Q000188:drug therapy / Q000473:pathology*; D002331:Carnitine / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008764:Methylmalonic Acid / Q000032:analysis*
D008764:Methylmalonic Acid; D002331:Carnitine