[Study on the chromosome aberration of peripheral blood lymphocytes in patients with nasopharyngeal carcinoma].
OBJECTIVE
To study the peripheral lymphocyte chromosome aberration in the patients with nasopharyngeal carcinoma.


METHODS
The peripheral blood lymphocytes, from 28 patients with nasopharyngeal carcinoma and 20 normal controls were cultured with TC199 medium for this study on chromosome aberration.


RESULTS
The chromosome number aberration rate, structure aberration rate, micronucleus rate and cell aberration rate of the peripheral lymphocytes from the patients with nasopharyngeal carcinoma were 8.68%, 10.89%, 1.83% and 8.65%, and these rates were significantly higher than those of normal controls, respectively (P < 0.05 or P < 0.01).


CONCLUSIONS
The above findings demonstrated the instability of chromosomes in the peripheral blood lymphocytes of nasopharyngeal carcinoma patients.
Gao
Chunsheng
C
Department of Otorhinolaryngology, Nanshang Hospital, Shenzhen 518052, China.
Xia
Fuzhen
F
D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*