The influence of alpha-zearalenol on magnesium concentration in cellular subfractions of certain tissues of female rats and their progeny.
The purpose of the research work was to study the influence of alpha-zearalenol on magnesium concentration in cellular subfractions of certain tissues of female rats and their progeny. Pregnant female rats received alpha-zearalenol at the doses of: 0.05, 0.5 or 1 mg x kg(-1) b.w. After delivery, brain, liver and kidneys of female rats and their progeny were removed and magnesium concentration was measured in cellular subfractions of these tissues. Alpha-zearalenol reduced Mg-level in all the cellular subfractions of female rat tissues. In progeny tissues, alpha-zearalenol decreased magnesium concentration in nuclear subfraction only. In mitochondrial and cytosol subfractions it increased Mg-concentration. The changes in magnesium concentration were depended on alpha-zearalenol doses and tissue nature. The magnesium concentration decrease was higher in female rats than in progeny tissues.
Pasternak
Kazimierz
K
Department of General Chemistry, Medical University of Lublin, Poland.
Kiełczykowska
Małgorzata
M
Sztanke
Małgorzata
M
Borzecki
Andrzej
A
D000818:Animals; D001921:Brain / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism*; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D008928:Mitochondria / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D017208:Rats, Wistar; D013347:Subcellular Fractions / Q000378:metabolism; D015029:Zeranol / Q000031:analogs & derivatives* / Q000494:pharmacology*
C029659:zearalenol; D015029:Zeranol; D008274:Magnesium