title: Acute coronary and peripheral arterial thrombosis following percutaneous coronary intervention in a patient with previously undiagnosed inherited thrombophilia.
abstract: Following pretreatment with ticlopidine 250 mg bid for three days, a 40-year-old man underwent successful angioplasty and stenting of the proximal left anterior descending coronary artery and balloon dilation of the midcircumflex coronary artery without stenting. He subsequently developed acute coronary thromboses at both arterial sites and cardiogenic shock. The patient survived after an additional percutaneous coronary intervention (PCI) and intra-aortic balloon pump assistance. This was followed by peripheral arterial thrombosis requiring repeated therapeutic interventions. Laboratory tests for thrombophilia revealed the presence of a G20210A prothrombin gene mutation. Two years later the patient remained free of angina and claudication, and underwent an unremarkable maximum exercise treadmill test. This is the first reported case of acute, multiple coronary and peripheral arterial thrombosis following PCI in a patient with previously unsuspected inherited thrombophilia. Inherited thrombophilia should be considered as a possible cause of arterial thrombosis following PCI.
authors.affiliation: University of Athens School of Medicine, Department of Clinical Therapeutics, Alexandra Hospital, Athens, Greece. Jnanas@ath.forthnet.gr
authors.forename: John N
authors.initials: JN
authors.lastname: Nanas
authors.forename: Alekos
authors.initials: A
authors.lastname: Gougoulakis
authors.forename: John
authors.initials: J
authors.lastname: Kanakakis
mesh_terms: D000208:Acute Disease; D000328:Adult; D015906:Angioplasty, Balloon, Coronary; D003328:Coronary Thrombosis / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D004252:DNA Mutational Analysis; D005263:Femoral Artery; D020022:Genetic Predisposition to Disease; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D007866:Leg / Q000098:blood supply; D008297:Male; D009203:Myocardial Infarction / Q000628:therapy*; D011516:Prothrombin / Q000235:genetics; D019233:Retreatment; D015607:Stents; D017131:Thrombectomy; D019851:Thrombophilia / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D013927:Thrombosis / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy
chemical_list: D011516:Prothrombin