[Insulin-like growth factor-I(IGF-I), and its binding protein-3 (IGFBP-3) correlated with fetal development].
OBJECTIVE
To study the relations between IGF-I, IGFBP-3 and human fetal growth.


METHODS
The blood samples of maternal serum (MS) and umbilical cord serum (UCS) from 81 cases with singleton term pregnancy including 38 cases of normal pregnancy (NP), 20 cases of gestational diabetic mellitus (GDM), 23 cases of macrosomia of non-diabetic pregnancy (MNDP) were examined for IGF-I and IGFBP-3 levels by immunoassay kit from DSL, USA.


RESULTS
IGF-I in MS of NP and MNDP showed a positive correlation with birth weight (BW) (r = 0.653 and r = 0.640 respectively, both P < 0.01). IGF-I of MS in MNDP was higher than that in NP (P < 0.05). IGF-I of MS and UCS in GDM were higher than that in NP (P < 0.05). IGF-I and IGFBP-3 of UCS in these three groups were significantly lower than that of MS (P < 0.001).


CONCLUSIONS
Detection of IGF-I in MS can assess fetal intra-uterus growth, birth weight and has certain value of predicting macrosomia. IGF-I and IGFBP-3 play important roles for human fetal growth.
Qian
M
M
Department of Gynecology and Obstetrics, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Fan
Q
Q
Bian
X
X
Zhu
L
L
Lang
J
J
D000328:Adult; D001724:Birth Weight; D016640:Diabetes, Gestational / Q000097:blood; D005314:Embryonic and Fetal Development; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005320:Fetal Macrosomia / Q000175:diagnosis; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D011247:Pregnancy; D011863:Radioimmunoassay
D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I