title: The effect of perioperative corticosteroids on the outcome of microscopic lumbar disc surgery.
abstract: Eighty adult patients with lumbar disc herniation verified by magnetic resonance imaging (MRI) and clinical findings corresponding to the radiological level underwent microscopic disc removal to evaluate the outcome of perioperatively given corticosteroids in a prospective randomized double-blind study. In the treatment group the patient received 250 mg Solu-Medrol intravenously and 160 mg Depo-Medrol intramuscularly. Before closure of the wound, a free fat transplant soaked in 80 mg Depo-Medrol was placed on the dural sac. In the control group the same procedure was performed, but sodium chloride was given instead of Depo-Medrol. All patients underwent a clinical examination before surgery and at 2, 6, 12, 26, 52 and 104 weeks postoperatively, rating their pain with the visual analog scale (VAS) and function with the Disability Rating Index (DRI). The postoperative hospital stay was significantly shorter (P=0.01) in the treatment group (1.7 days) compared to the control group (2.3 days). Time taken to return to full-time work was also significantly shorter in the treatment group (P=0.003). VAS-W (Worst Pain during last week) was significantly lower in the treatment group (P=0.02). Postoperative spondylitis occurred in one patient in the control group and no adverse corticosteroids effect was seen. Our study shows that perioperatively given corticosteroids improve the outcome of microscopic disc surgery in terms of length of hospital stay and time taken to return to full-time work. The results also indicate that corticosteroid treatment reduces pain and improves functional outcome.
authors.affiliation: Department of Orthopaedics, Orebro University Hospital, 701 85 Orebro, Sweden. anders.lundin@orebroll.se
authors.forename: Anders
authors.initials: A
authors.lastname: Lundin
authors.forename: Anders
authors.initials: A
authors.lastname: Magnuson
authors.forename: Kjell
authors.initials: K
authors.lastname: Axelsson
authors.forename: Heinz
authors.initials: H
authors.lastname: Kogler
authors.forename: Lars
authors.initials: L
authors.lastname: Samuelsson
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D002921:Cicatrix / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control*; D004185:Disability Evaluation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control*; D007405:Intervertebral Disc Displacement / Q000601:surgery*; D007902:Length of Stay; D008159:Lumbar Vertebrae / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008775:Methylprednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077555:Methylprednisolone Acetate; D008866:Microsurgery; D010149:Postoperative Pain / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control*; D019990:Perioperative Care / Q000379:methods* / Q000706:statistics & numerical data; D011446:Prospective Studies; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000077555:Methylprednisolone Acetate; D008775:Methylprednisolone