title: Dynamin recruitment by clathrin coats: a physical step?
abstract: Recent structural findings have shown that dynamin, a cytosol protein playing a key-role in clathrin-mediated endocytosis, inserts partly within the lipid bilayer and tends to self-assemble around lipid tubules. Taking into account these observations, we make the hypothesis that individual membrane-inserted dynamins imprint a local cylindrical curvature to the membrane. This imprint may give rise to long-range mechanical forces mediated by the elasticity of the membrane. Calculating the resulting many-body interaction between a collection of inserted dynamins and a membrane bud, we find a regime in which the dynamins are elastically recruited by the bud to form a collar around its neck, which is reminiscent of the actual process preempting vesicle scission. This physical mechanism might therefore be implied in the recruitment of dynamins by clathrin coats.
authors.affiliation: Laboratoire de physico-chimie théorique, FR CNRS 2438 Matière et Systèmes complexes, ESPCI, 10, rue Vauquelin, 75231 Paris, France. jbf@turner.pct.espci.fr
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Fournier
authors.forename: Paul G
authors.initials: PG
authors.lastname: Dommersnes
authors.forename: Paola
authors.initials: P
authors.lastname: Galatola
mesh_terms: D001696:Biomechanical Phenomena; D002462:Cell Membrane / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure; D022163:Clathrin-Coated Vesicles / Q000378:metabolism*; D034281:Dynamins / Q000378:metabolism*; D004548:Elasticity; D008051:Lipid Bilayers / Q000378:metabolism; D008433:Mathematics; D008954:Models, Biological; D009010:Monte Carlo Method
chemical_list: D008051:Lipid Bilayers; D034281:Dynamins