title: DNA dynamics in a microchannel.
abstract: An extended Brownian dynamics simulation method is used to characterize the dynamics of long DNA molecules flowing in microchannels. The relaxation time increases due to confinement in agreement with scaling predictions. During flow the molecules migrate toward the channel center line, and thereby segregate according to molecular weight. Capturing these effects requires the detailed incorporation of solvent flow in the simulation method, demonstrating the importance of hydrodynamic effects in the dynamics of confined macromolecules.
authors.affiliation: Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Jendrejack
authors.forename: Eileen T
authors.initials: ET
authors.lastname: Dimalanta
authors.forename: David C
authors.initials: DC
authors.lastname: Schwartz
authors.forename: Michael D
authors.initials: MD
authors.lastname: Graham
authors.forename: Juan J
authors.initials: JJ
authors.lastname: de Pablo
mesh_terms: D003198:Computer Simulation; D004247:DNA / Q000737:chemistry*; D007700:Kinetics; D008956:Models, Chemical; D013269:Stochastic Processes; D014783:Viscosity
chemical_list: D004247:DNA