Cerebrospinal fluid (CSF) and serum S100B: release and wash-out pattern.
S100B is an important brain specific protein for monitoring damage and activation of astrocytes. Using a straight forward, non-resource demanding in-house ELISA technique we measured S100B in cerebrospinal fluid (CSF) and serum in patients with traumatic brain injury (TBI) (serum), subarachnoid hemorrhage (SAH) (CSF, serum), intracranial hemorrhage (ICH) (CSF, serum), normal controls (NC) (serum) and a reference population (CSF, N=409). The release and wash-out pattern found in CSF and serum are discussed in relation to the three main determinants for increased brain specific protein levels in body fluids: (i) total mass effect; (ii) pathology; and (iii) time effect.
Petzold
A
A
Department of Neuroimmunology of the Institute of Neurology, Queen Square, WC1N 3BG London, UK.
Keir
G
G
Lim
D
D
Smith
M
M
Thompson
E J
EJ
D000328:Adult; D001253:Astrocytes / Q000473:pathology; D001927:Brain Diseases / Q000097:blood / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid; D009418:S100 Proteins / Q000097:blood / Q000134:cerebrospinal fluid*; D013997:Time Factors
D009418:S100 Proteins; C110294:S100A1 protein