A randomized trial comparing 35Gy in ten fractions with 60Gy in 30 fractions of cerebral irradiation for glioblastoma multiforme and older patients with anaplastic astrocytoma.
A randomized prospective clinical trial was conducted to compare conventional high dose radiotherapy with hypofractionated, short course radiotherapy in poor prognosis patients with high grade glioma. The primary endpoint was overall survival.
Phillips
Claire
C
Division of Radiation Oncology, Peter MacCallum Cancer Centre, Victoria, East Melbourne, Australia.
Guiney
Michael
M
Smith
Jennifer
J
Hughes
Peter
P
Narayan
Kailash
K
Quong
George
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001254:Astrocytoma / Q000401:mortality / Q000532:radiotherapy*; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D005260:Female; D005909:Glioblastoma / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011788:Quality of Life; D015996:Survival Rate; D016896:Treatment Outcome