[Collagen type I expression in squamous cell carcinoma of the oral cavity].
An analysis of the extracellular matrix at the invasive front of squamous cell carcinoma of the oral cavity may improve the understanding of tumour cell matrix interactions during malignancy growth. Alterations in collagen I expression may influence cellular invasion and metastasis. In this work, 23 cases of squamous cell carcinoma were submitted to the Anneroth's malignancy grading system. H. E. and sirius red staining were used. Immuno-histochemical expression of collagen type I protein was observed in different malignancy scores. As a result, it was observed that the extracellular matrix in squamous cell carcinoma of the oral cavity shows different patterns of collagen I expression in low and high scores of malignancy.
Martins
Gabriela Botelho
GB
Faculdade de Medicina, Universidade Federal da Bahia.
Reis
Sílvia Regina
SR
Silva
Tânia Maria
TM
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D024042:Collagen Type I / Q000737:chemistry / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000378:metabolism*
D024042:Collagen Type I; D009363:Neoplasm Proteins