title: Epidemiological, clinical, and prognostic differences between the diseases caused by Mycobacterium kansasii and Mycobacterium tuberculosis in patients infected with human immunodeficiency virus: a multicenter study.
abstract: A multicenter, comparative study was performed to determine the epidemiological, clinical, and prognostic differences between the diseases caused by Mycobacterium tuberculosis and Mycobacterium kansasii in human immunodeficiency virus (HIV)-infected patients. From 1 January 1995 through 31 December 1999, 25 HIV-infected patients received diagnoses of M. kansasii infection, and another 75 were selected as control subjects from among patients who had M. tuberculosis infection. Variables associated with M. tuberculosis disease in the multivariate analysis were previous intravenous drug use (odds ratio [OR], 8; 95% confidence interval [CI], 1.5-41.4) and interstitial radiologic pattern (OR, 12.7; 95% CI, 1.7-94.3). Variables associated with M. kansasii were previous diagnosis of acquired immunodeficiency syndrome (OR, 15.8; 95% CI, 4.2-59.6) and concomitant opportunistic infections (OR, 14.2; 95% CI, 2-105.7). Clinical and radiologic features were similar for both groups, but epidemiological characteristics and prognosis were different. M. kansasii disease was associated more closely with level of immunosuppression and progression of HIV infection than was disease caused by M. tuberculosis.
authors.affiliation: Infectious Diseases Section, Punta de Europa Hospital, Algeciras, Spain. j.canueto@comcadiz.com
authors.forename: Jesús
authors.initials: J
authors.lastname: Canueto-Quintero
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Caballero-Granado
authors.forename: Marta
authors.initials: M
authors.lastname: Herrero-Romero
authors.forename: Angel
authors.initials: A
authors.lastname: Domínguez-Castellano
authors.forename: Patricia
authors.initials: P
authors.lastname: Martín-Rico
authors.forename: Elisa Vidal
authors.initials: EV
authors.lastname: Verdú
authors.forename: Daniel Selma
authors.initials: DS
authors.lastname: Santamaría
authors.forename: Ricardo Creagh
authors.initials: RC
authors.lastname: Cerquera
authors.forename: Manuel
authors.initials: M
authors.lastname: Torres-Tortosa
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology*; D000328:Adult; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000503:physiopathology*; D019909:Mycobacterium kansasii; D009169:Mycobacterium tuberculosis; D014397:Tuberculosis, Pulmonary / Q000503:physiopathology*