title: Usefulness of bovine pericardium as interpositional graft in the surgical repair of nasal septal perforations (experimental study).
abstract: A 2.5-cm nasal septal perforation was performed in 18 pigs and repaired as follows: group I (n = 6), septal perforation without treatment; group II (n = 6), surgical repair with interpositional graft of glutaraldehyde-preserved bovine pericardium (GPBP); group III (n = 6), surgical repair with interpositional graft of lyophilized GPBP (LGPBP). The animals were evaluated clinically and radiologically (x-ray and CT scan) 2 days before surgery, daily during the first postoperative week, and weekly during the next 6 months. At the end of the study the animals were euthanized with an overdose of pentobarbital. Macroscopic and microscopic examination of the grafts and nasal septum was performed. All the animals survived the surgical procedure. Five pigs in group I showed persistence of the septal perforation. All the animals in groups II and III showed total closure of the septal perforation, with the presence of fibrotic tissue on the pericardial grafts as well as in the septal cartilage, and overall good healing. In conclusion, GPBP and LGPBP are adequate materials that can be used as interpositional grafts in the surgical closure of septal perforations in pigs
authors.affiliation: Department of Experimental Surgery, National Institute of Respiratory Diseases, Mexico City, Mexico.
authors.forename: Rogelio
authors.initials: R
authors.lastname: Jasso-Victoria
authors.forename: J Raul
authors.initials: JR
authors.lastname: Olmos-Zuñiga
authors.forename: L Miguel
authors.initials: LM
authors.lastname: Gutierrez-Marcos
authors.forename: Avelina
authors.initials: A
authors.lastname: Sotres-Vega
authors.forename: J Ramon
authors.initials: JR
authors.lastname: Manjarrez Velazquez
authors.forename: Miguel
authors.initials: M
authors.lastname: Gaxiola-Gaxiola
authors.forename: Arturo
authors.initials: A
authors.lastname: Avila-Chavez
authors.forename: Guillermo
authors.initials: G
authors.lastname: Avendaño Moreno
authors.forename: Patricio
authors.initials: P
authors.lastname: Santillan-Doherty
mesh_terms: D000818:Animals; D002417:Cattle; D002425:Cautery / Q000009:adverse effects; D003452:Cryosurgery / Q000009:adverse effects; D005260:Female; D008297:Male; D009300:Nasal Septum / Q000293:injuries* / Q000601:surgery*; D010496:Pericardium / Q000637:transplantation*; D011183:Postoperative Complications / Q000601:surgery; D034421:Sus scrofa; D014183:Transplantation, Heterologous; D014945:Wound Healing