title: [Somatostatin mRNA expression in hippocampus of diabetic rats model].
abstract: OBJECTIVE
  To investigate the relationship between diabetes and somatostatin (SOM).
  
  
  METHODS
  We established a streptozocin-induced diabetic rats model and studied the changes of SOM mRNA in hippocampi of diabetic and normal rats by using in situ hybridication and computer image analysis. We studied the mechanism of chronic diabetes encephalopathy by observing the changes of somatostatin mRNA in the hippocampus of diabetic rats was studied.
  
  
  RESULTS
  The number, light density and average area of positive cells in dentate gyrus area of hippocampus in diabetes model were reduced significantly as compared with normal rats (P < 0.01).
  
  
  CONCLUSIONS
  A decline in SOM mRNA expression may play a role in chronic diabetes encephalopathy because of SOM effect in brain.
authors.affiliation: Institute of Cell Biology and Tissue Engineering, Medical College of Zhejiang University, Hangzhou 310006, China. zxm@zju.edu.cn
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Zhang
authors.forename: Xi
authors.initials: X
authors.lastname: Zhu
authors.forename: Zhang-gen
authors.initials: ZG
authors.lastname: Yuan
authors.forename: Jun
authors.initials: J
authors.lastname: Yu
authors.forename: Ji-lin
authors.initials: JL
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000209:etiology / Q000378:metabolism; D018891:Dentate Gyrus / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D013004:Somatostatin