title: Performance in the cross-maze and slip funnel tests of four pairs of rat lines selectively bred for divergent alcohol drinking behavior.
abstract: Alcohol naive rats from lines genetically selected for high and low alcohol drinking and founded on either Wistar (P/NP lines) and distinct heterogeneous stocks (AA/ANA and replicate HAD/LAD lines) were tested in the explorative cross-maze and the inescapable slip funnel. Rats of the low alcohol-consuming ANA, NP, LAD1 and LAD2 lines all exhibited a shorter latency before initiating exploration of the maze than did their high alcohol-consuming counterparts (66, 51, 33 and 51% of the values for AA, P, HAD1 and HAD2 lines, respectively). Significant line differences were also found with the slip funnel test (AA > ANA for time in a sprawling posture; P > NP but HAD1 < LAD1 and HAD2 < LAD2 for time escaping), but the directions of line differences were not consistently related to those in alcohol drinking.
authors.affiliation: Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: R M
authors.initials: RM
authors.lastname: Salimov
authors.forename: W J
authors.initials: WJ
authors.lastname: McBride
authors.forename: J D
authors.initials: JD
authors.lastname: Sinclair
authors.forename: L
authors.initials: L
authors.lastname: Lumeng
authors.forename: T
authors.initials: T
authors.lastname: Li