title: Synthesis of oligonucleotides using the 2-(levulinyloxymethyl)-5-nitrobenzoyl group for the 5'-position of nucleoside 3'-H-phosphonate and -H-phosphonothioate derivatives.
abstract: Synthetic studies on phosphodiester, phosphorothioate, and phosphorodithioate-linked oligonucleotides in terms of 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBz) group as the base-labile protecting group for the 5'-hydroxyl groups of nucleoside 3'-H-phosphonate and -H-phosphonothioate derivatives, are described.
authors.affiliation: Laboratory of Pharmaceutical Chemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kamaike
authors.forename: K
authors.initials: K
authors.lastname: Hirose
authors.forename: E
authors.initials: E
authors.lastname: Kawashima
mesh_terms: D002851:Chromatography, High Pressure Liquid; D007982:Levulinic Acids / Q000737:chemistry; D015394:Molecular Structure; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D013873:Thionucleotides / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D007982:Levulinic Acids; D009841:Oligonucleotides; D013873:Thionucleotides