Respiratory activity of bulbospinal preparations from newborn rats subjected to periodic hypercapnia in the prenatal period.
Periodic exposure of pregnant rats to hypercapnia (10% CO(2)) delayed the development of mechanisms underlying respiratory rhythmogenesis in newborn animals during the early postnatal period. In vitro studies showed that rhythmic activity of the respiratory center in newborn rats (days 0-3) was 2-3-fold lower than that in intact preparations. Age-related changes of respiratory activity were absent, while the reactions of the respiratory center to CO(2) were suppressed compared to the control.
Miroshnichenko
I V
IV
Samara State Medical University. miv2000@mailru.com
Pyatin
V F
VF
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D004525:Efferent Pathways; D004622:Embryo, Mammalian / Q000502:physiology; D005260:Female; D006935:Hypercapnia; D018811:Maternal Exposure; D008526:Medulla Oblongata / Q000166:cytology* / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D012119:Respiration; D013116:Spinal Cord / Q000166:cytology* / Q000378:metabolism