title: Lymphadenopathy of sinus histiocytosis mimicking metastatic bladder cancer: a case report.
abstract: A case of invasive bladder cancer accompanied with enlarged pelvic lymph nodes, which were interpreted as metastasis, is reported. The lymphadenopathy eventually regressed spontaneously while the bladder cancer increased in size. Total cystectomy and pelvic lymph node dissection were performed. Histopathological examination of the lymph nodes revealed dilation of the sinuses and marked increase in the number of histiocytes, which suggested sinus histiocytosis. Sinus histiocytosis is often associated with malignant tumor. It is considered as a sign of the host's immune activation with favorable prognostic significance. Nevertheless, such lymphadenopathy mimics a metastatic lymph node, making proper staging difficult.
authors.affiliation: Department of Urology, Tokyo Metropolitan Tama Geriatric Hospital, Japan. touko@bg7.so-net.ne.jp
authors.forename: Touko
authors.initials: T
authors.lastname: Asano
authors.forename: Yukirhio
authors.initials: Y
authors.lastname: Ohtsuka
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takagi
authors.forename: Junko
authors.initials: J
authors.lastname: Aida
authors.forename: Yume
authors.initials: Y
authors.lastname: Okada
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ito
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000473:pathology*; D015653:Cystectomy / Q000379:methods; D003937:Diagnosis, Differential; D015618:Histiocytosis, Sinus / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008206:Lymphatic Diseases / Q000473:pathology*; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000473:pathology*