Genetic approaches to the study of synaptic plasticity and memory storage.
Long-term memory is believed to depend on long-lasting changes in the strength of synaptic transmission known as synaptic plasticity. Understanding the molecular mechanisms of long-term synaptic plasticity is one of the principle goals of neuroscience. Among the most powerful tools being brought to bear on this question are genetically modified mice with changes in the expression or biological activity of genes thought to contribute to these processes. This article reviews how strains of mice with alterations in the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-response element-binding protein signaling pathway have advanced our understanding of the biological basis of learning and memory.
Kaplan
Michael P
MP
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018, USA. abele@sas.upenn.edu
Abel
Ted
T
D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics; D001921:Brain / Q000502:physiology*; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics; D017868:Cyclic AMP-Dependent Protein Kinases / Q000235:genetics; D006801:Humans; D017774:Long-Term Potentiation / Q000235:genetics / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009473:Neuronal Plasticity / Q000235:genetics*; D012153:Retention, Psychology / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics*; D009435:Synaptic Transmission / Q000235:genetics*
D017362:Cyclic AMP Response Element-Binding Protein; D017868:Cyclic AMP-Dependent Protein Kinases