Design, synthesis, and biological properties of highly potent epothilone B analogues.
Nicolaou
K C
KC
Department of Chemistry and, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. kcn@scripps.edu
Sasmal
Pradip K
PK
Rassias
Gerasimos
G
Reddy
Mali Venkat
MV
Altmann
Karl-Heinz
KH
Wartmann
Markus
M
O'Brate
Aurora
A
Giannakakou
Paraskevi
P
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D015195:Drug Design; D004351:Drug Resistance; D004354:Drug Screening Assays, Antitumor; D034261:Epothilones / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D017239:Paclitaxel / Q000494:pharmacology; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D034261:Epothilones; D017239:Paclitaxel; C093788:epothilone B