Myosin VI: two distinct roles in endocytosis.
Actin is found at the cortex of the cell where endocytosis occurs, but does it play a role in this essential process? Recent studies on the unconventional myosin, myosin VI, an actin-based molecular motor, provide compelling evidence that this myosin and therefore actin is involved in two distinct steps of endocytosis in higher eukaryotes: the formation of clathrin-coated vesicles and the movement of nascent uncoated vesicles from the actin-rich cell periphery to the early endosome. Three distinct adapter proteins--GIPC, Dab2 and SAP97--that associate with the cargo-binding tail domain of myosin VI have been identified. These proteins may recruit myosin VI to its sites of action.
Hasson
Tama
T
Division of Biological Sciences, Section of Cell and Developmental Biology, University of California at San Diego, 2129 Bonner Hall, MC 0368, 9500 Gilman Drive, La Jolla, CA 92093-0368, USA. tama@ucsd.edu
D000199:Actins / Q000378:metabolism*; D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism; D000818:Animals; D051017:Apoptosis Regulatory Proteins; D002352:Carrier Proteins / Q000378:metabolism; D022163:Clathrin-Coated Vesicles / Q000378:metabolism*; D000074288:Discs Large Homolog 1 Protein; D004705:Endocytosis / Q000502:physiology*; D011992:Endosomes / Q000378:metabolism*; D016147:Genes, Tumor Suppressor; D006801:Humans; D008565:Membrane Proteins; D018995:Myosin Heavy Chains / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D022161:Transport Vesicles / Q000378:metabolism; D025521:Tumor Suppressor Proteins
D000199:Actins; D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport; D051017:Apoptosis Regulatory Proteins; D002352:Carrier Proteins; C102885:DAB2 protein, human; C513314:DLG1 protein, human; D000074288:Discs Large Homolog 1 Protein; C492009:GIPC1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D025521:Tumor Suppressor Proteins; C089785:myosin VI; D018995:Myosin Heavy Chains