High circulating frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4+ T cells in patients with HTLV-1-associated neurological disease.
Significantly higher frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4(+) T cells were present in the peripheral blood mononuclear cells of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients than in those of asymptomatic carriers with similar provirus loads. The data suggest that HTLV-1-specific CD4(+) T cells play a role in the pathogenesis of HAM/TSP.
Goon
Peter K C
PK
Department of Immunology, Imperial College London, London W2 1PG, United Kingdom.
Igakura
Tadahiko
T
Hanon
Emmanuel
E
Mosley
Angelina J
AJ
Asquith
Becca
B
Gould
Keith G
KG
Taylor
Graham P
GP
Weber
Jonathan N
JN
Bangham
Charles R M
CR
D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000821:virology*; D002353:Carrier State / Q000276:immunology; D004768:Enterotoxins / Q000494:pharmacology; D015368:Human T-lymphotropic virus 1 / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis*; D008233:Lymphotoxin-alpha / Q000096:biosynthesis; D015493:Paraparesis, Tropical Spastic / Q000209:etiology / Q000276:immunology*; D011533:Proviruses / Q000276:immunology / Q000302:isolation & purification; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D004768:Enterotoxins; D007376:Interleukin-2; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha; C031818:enterotoxin B, staphylococcal; D007371:Interferon-gamma; D013755:Tetradecanoylphorbol Acetate