title: Glatiramer acetate treatment in patients with childhood and juvenile onset multiple sclerosis.
abstract: BACKGROUND
  Recent data indicate that in multiple sclerosis disease onset before the age of 16 is more common than previously assumed. However, current therapeutic options are limited to the treatment of acute attacks in these patients. Glatiramer acetate has been successfully applied in adults with relapsing-remitting multiple sclerosis, but there are no data available about the use of glatiramer acetate in childhood and juvenile onset multiple sclerosis.
  
  
  METHODS
  Seven patients with relapsing-remitting multiple sclerosis and disease onset between 9 and 16 years of age were treated with daily subcutaneous injection of 20 mg glatiramer acetate (Copaxone). Patients were followed for 24 months. Treatment was initiated in all patients before the age of 18.
  
  
  RESULTS
  The use of glatiramer acetate in our cohort of early onset multiple sclerosis patients was safe and well tolerated. Two out of seven patients remained relapse-free during the two year period. Clinical disability as measured by the EDSS remained stable in three out of seven patients.
  
  
  CONCLUSIONS
  Due to the small number of patients the efficacy of the treatment has to be interpreted with caution. However, there might be a more pronounced treatment benefit in patients with low disability at treatment initiation and early treatment onset.
authors.affiliation: Department of Neuropsychiatry of Childhood and Adolescence, University of Vienna, Vienna, Austria. barbara.kornek@univie.ac.at
authors.forename: B
authors.initials: B
authors.lastname: Kornek
authors.forename: G
authors.initials: G
authors.lastname: Bernert
authors.forename: C
authors.initials: C
authors.lastname: Balassy
authors.forename: J
authors.initials: J
authors.lastname: Geldner
authors.forename: D
authors.initials: D
authors.lastname: Prayer
authors.forename: M
authors.initials: M
authors.lastname: Feucht
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000627:therapeutic use*; D000293:Adolescent; D001921:Brain / Q000473:pathology*; D002648:Child; D003937:Diagnosis, Differential; D004172:Diplopia / Q000175:diagnosis; D004185:Disability Evaluation; D005074:Evoked Potentials, Visual; D005260:Female; D000068717:Glatiramer Acetate; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D010455:Peptides / Q000009:adverse effects / Q000627:therapeutic use*; D012008:Recurrence
chemical_list: D000276:Adjuvants, Immunologic; D010455:Peptides; D000068717:Glatiramer Acetate