title: Dose distributions in bifurcated coronary vessels treated with catheter-based photon and beta emitters in intravascular brachytherapy.
abstract: The dose distributions in the bifurcated vessels treated with intravascular brachytherapyline sources are complicated and depend on the bifurcation geometry consisting of a main and a branch vessel at different angles. To investigate the dosimetric effects at the bifurcation, calculations were performed on branching vessels of various bifurcation angles ranging from 20 degrees to 90 degrees. Two catheter based delivery systems were considered in the calculations using a 40 mm long radioactive sources of 192Ir or 90Sr/Y. It was assumed that the bifurcated vessel was treated in twoseparate source insertions, once for the main vessel and later for the branch vessel. Calculations were performed for different values of source gap from 0 to 9 mm, at the junction of main and branch vessels. Our results indicate that main vessel always receives a higher dose (up to 200%) when the branch vessel is also treated. Hot spots at portions of the main vessel near the junction cannot be totally avoided without severely underdosing the branch vessel. For bifurcation angle greater than 45 degrees, a 4 mm source gap can almost ensure that overdosing of the main vessel does not exceed 60% and underdosing of the branch vessel does not exceed 10% for 192Ir. However, for 90Sr/Y, the same is not possible unless the bifurcation angle is larger than 70 degrees. Dose heterogeneity using 90Sr/Y is more sensitive to the value of source gap than 192Ir because 90Sr/Y source provides a sharper dose-fall-off than 192Ir. For both photon and beta emitters, there is no acceptable solution for bifurcation angles less than 30 degrees, where the activity of the line source has a uniform distributions. Appropriate choice of gap at the junction can only help to reduce either overdosing of the main vessel or underdosing of the branch vessel, but not both.
authors.affiliation: Department of Therapeutic Radiology, PO Box 208040, Yale University School of Medicine, New Haven, Connecticut 06520-8040, USA.
authors.forename: Ning
authors.initials: N
authors.lastname: Yue
authors.forename: Kenneth B
authors.initials: KB
authors.lastname: Roberts
authors.forename: Steven E
authors.initials: SE
authors.lastname: Pfau
authors.forename: Ravinder
authors.initials: R
authors.lastname: Nath
mesh_terms: D001610:Beta Particles / Q000627:therapeutic use*; D001918:Brachytherapy / Q000379:methods*; D002406:Catheterization, Peripheral / Q000379:methods*; D003198:Computer Simulation; D023903:Coronary Restenosis / Q000517:prevention & control / Q000532:radiotherapy; D003331:Coronary Vessels / Q000503:physiopathology* / Q000528:radiation effects; D005240:Feasibility Studies; D006801:Humans; D008955:Models, Cardiovascular; D017785:Photons / Q000627:therapeutic use*; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity