[The multidrug resistance modulators heterocondensed quinazolones].
Exploration for new MDR-modulators utilizing pyrazino[2,1-b]quinazolones as scaffolds disclosed after systematic synthetic investigation highly hydrophobic N-substituted derivatives as a readily accessible active tricyclic compounds. A versatile synthesis of 2-substituted-1,2,3,4-tetrahydro-6H-pyrazino[2,1-b]quinazoline-3,6-diones is presented starting from 2,3-substituted quinazolines. The new compounds have been characterized by elemental analyses, 1H nmr and in some cases by 13C ruler, and X-ray investigations.
Kökösi
József
J
Semmelweis Egyetem, Gyógyszerészi Kémiai Intézet, Budapest, Hógyes E. u. 9.-1092.
Almási
János
J
Podányi
Benjamin
B
Hermecz
István
I
D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000378:metabolism; D018432:Drug Resistance, Multiple; D007202:Indicators and Reagents; D008958:Models, Molecular; D015394:Molecular Structure; D011487:Protein Conformation; D011719:Pyrazines / Q000737:chemistry; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry*; D014961:X-Ray Diffraction
D018528:ATP-Binding Cassette Transporters; D007202:Indicators and Reagents; D011719:Pyrazines; D011799:Quinazolines