[Patient-controlled analgesia with lornoxicam in patients undergoing gynecological surgery].
OBJECTIVE
To assess the analgesic effect and side effects of PCA with lornoxicam compared with morphine and tramadol.


METHODS
89 patients, scheduled for elective hysterectomy or hysteromyomectomy, were randomly divided into Group L, Group M and Group T. Three drugs administered i.v. via a patient-controlled analgesia for up to 24 h postoperatively.


RESULTS
Efficacy was assessed by comparing total pain relief (TOTPAR) and sum of pain intensity difference (SPID) over 24 h. Statistically significant equivalence of lornoxicam, morphine and tramadol was shown by TOTPAR values 15.2 +/- 3.9, 16.4 +/- 3.5 and 15.9 +/- 4.4, by SPID values 10.3 +/- 3.1, 9.0 +/- 2.0 and 9.2 +/- 4.7, respectively (P > 0.05). Lornoxicam caused fewer adverse events than morphine and tramadol (10.0%, 26.7% and 17.2% of patients, respectively).


CONCLUSIONS
The study suggests that lornoxicam provides an alternative to morphine or tramadaol for the treatment of postoperative pain.
Gong
Z Y
ZY
Department of Anesthesiology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China. gongzy@csc.pumch.ac.cn
Ye
T H
TH
Qin
X T
XT
Yu
G X
GX
Guo
X Y
XY
Luo
A L
AL
D000328:Adult; D000368:Aged; D016058:Analgesia, Patient-Controlled / Q000379:methods*; D000701:Analgesics, Opioid / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D014147:Tramadol / Q000627:therapeutic use; D016896:Treatment Outcome
D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D014147:Tramadol; D009020:Morphine; C059451:lornoxicam