[A 3-amino acid deletion of apolipoprotein E found in 3 Chinese lipoprotein glomerulopathy patients].
OBJECTIVE
To analyze the mutation of apolipoprotein E (apoE) gene so as to investigate the pathogenesis of lipoprotein glomerulopathy (LPG).


METHODS
Restriction fragment length polymorphism methods was used to analyze the apoE genotypes of three Chinese patients with LPG and 3 of their relatives. Automated DNA sequencing was performed upon their apoE genes.


RESULTS
A 9-bp deletion in exon 4 of apoE, resulting in a 3-amino acid deletion (residues 142-144-0) was identified.


CONCLUSIONS
A 3-amino acid deletion of apoE has been discovered which is associated with LPG.
Chen
Yu-qing
YQ
Department of Nephrology, First Hospital of Peking University, Beijing 100034, China.
Zhang
Hong
H
Zhu
Shi-le
SL
Zou
Wan-zhong
WZ
Wang
Mei
M
Liu
Zhang-suo
ZS
Wang
Hai-yan
HY
D000293:Adolescent; D000328:Adult; D000595:Amino Acid Sequence; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics* / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion
D001057:Apolipoproteins E