Control of DNA photocleavage by oligothiazole derivatives.
Mechanism of DNA damage by the p-cyanobenzamide (pCyBz)-oligothiazole derivatives were investigated by HPLC analysis. The oxidation product of dG by the photocleaver was imidazolone (dIz).
Ninomiya
K
K
Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan.
Kuroda
R
R
D001665:Binding Sites; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000737:chemistry / Q000187:drug effects* / Q000528:radiation effects*; D004249:DNA Damage; D006147:Guanine / Q000737:chemistry; D066298:In Vitro Techniques; D010084:Oxidation-Reduction; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D013844:Thiazoles / Q000494:pharmacology*; D014466:Ultraviolet Rays
D017319:Photosensitizing Agents; D013844:Thiazoles; D006147:Guanine; D004247:DNA