title: Comparison of left ventricular function by echocardiogram in patients with Wilms' tumor treated with anthracyclines versus those not so treated.
abstract: The aim of this report was to evaluate late left ventricular function in survivors of Wilms' tumor and to compare patients treated with anthracyclines with those treated without anthracycline and with normal subjects. Wilms' tumor survivors treated without anthracycline had no myocardial abnormalities. A large percentage of patients treated with anthracycline presented with increased end-systolic wall stress. Results indicate that there is a high incidence of subclinical cardiovascular abnormalities in such patients.
authors.affiliation: Cattedra di Cardiologia, Dipartimento di Scienze Cardio-Chirurgiche, Toraciche e Respiratorie, Naples, Italy. dianal.iarussi@unina2.it
authors.forename: Diana
authors.initials: D
authors.lastname: Iarussi
authors.forename: Paolo
authors.initials: P
authors.lastname: Indolfi
authors.forename: Carlo
authors.initials: C
authors.lastname: Pisacane
authors.forename: Fiorina
authors.initials: F
authors.lastname: Casale
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Martino
authors.forename: Angela
authors.initials: A
authors.lastname: Fusco
authors.forename: Emilia
authors.initials: E
authors.lastname: De Rosa
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Di Tullio
authors.forename: Raffaele
authors.initials: R
authors.lastname: Calabrò
mesh_terms: D000293:Adolescent; D000328:Adult; D018943:Anthracyclines / Q000627:therapeutic use*; D001837:Body Weights and Measures; D002306:Cardiac Volume / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D012016:Reference Values; D017741:Survivors; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects*; D009396:Wilms Tumor / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: D018943:Anthracyclines