Cytotoxic anthraquinones from the stems of Rubia wallichiana Decne.
From the stems of Rubia wallichiana DECNE, thirty-four structurally related compounds were isolated and identified. Three of them, namely rubiawallin-A (1), -B (2), and -C (3), constitute the first report of their occurrence from the natural source. Their structures were determined by comprehensive analyses of their 1D and 2D NMR, and electron impact (EI) mass spectral data. Furthermore, an in vitro screening of cytotoxicity of the isolated compounds was also evaluated. Among the testing compounds, 1-hydroxy-2-hydroxymethyl-3-methoxyanthraquinone (4) demonstrated most effective cytotoxicity towards Hepa-3B and Colo-205 cells.
Wu
Tian-Shung
TS
Department of Chemistry, National Cheng Kung University, Taiwan. tswu@mail.ncu.edu.tw
Lin
Dau-Min
DM
Shi
Li-Shian
LS
Damu
Amooru Gangaiah
AG
Kuo
Ping-Chung
PC
Kuo
Yao-Hau
YH
D000880:Anthraquinones / Q000737:chemistry / Q000633:toxicity*; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry*; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity; D018547:Plant Stems; D045470:Rubia / Q000633:toxicity*
D000880:Anthraquinones; D003603:Cytotoxins; D010936:Plant Extracts