Genetic dissection of psychopathological symptoms: insomnia in mood disorders and CLOCK gene polymorphism.
We investigated the possible effect of the 3111T/C CLOCK gene polymorphism on sleep disorders in a sample of 620 patients affected by major depressive disorder (MDD) and bipolar disorder (BP). We detected a significantly higher recurrence of initial (P = 0.0001), middle (P = 0.0009), and early (P = 0.0008) insomnia in homozygotes for the C variant and a similar trend concerning decreased need of sleep in BP (P = 0.0074). Other demographic and clinical features were found not related with CLOCK polymorphisms. This preliminary observation leads to hypothesize a possible involvement of the CLOCK gene polymorphism in the sleep disregulations in MDD and BP.
Serretti
Alessandro
A
Department of Psychiatry, Vita-Salute University, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy. serretti.alessandro@hsr.it
Benedetti
Francesco
F
Mandelli
Laura
L
Lorenzi
Cristina
C
Pirovano
Adele
A
Colombo
Cristina
C
Smeraldi
Enrico
E
D000328:Adult; D056926:CLOCK Proteins; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000235:genetics*; D007319:Sleep Initiation and Maintenance Disorders / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics*
D015534:Trans-Activators; D056926:CLOCK Proteins; C538943:CLOCK protein, human