title: Escherichia coli cells bearing a ribosomal ambiguity mutation in rpsD have a mutator phenotype that correlates with increased mistranslation.
abstract: Escherichia coli cells bearing certain mutations in rpsD (coding for the 30S ribosomal protein S4) show a ribosomal ambiguity (Ram) phenotype characterized by increased translational error rates. Here we show that spontaneous mutagenesis increases in Ram cells bearing the rpsD14 allele, suggesting that the recently described translational stress-induced mutagenesis pathway is activated in Ram cells.
authors.affiliation: University of Medicine and Dentistry of New Jersey--New Jersey Medical School, Department of Microbiology and Molecular Genetics, International Center for Public Health, Newark, New Jersey 07101-1709, USA.
authors.forename: Sergey
authors.initials: S
authors.lastname: Balashov
authors.forename: M Zafri
authors.initials: MZ
authors.lastname: Humayun
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development / Q000502:physiology*; D008826:Microbial Sensitivity Tests; D009154:Mutation; D010641:Phenotype; D014176:Protein Biosynthesis / Q000187:drug effects; D012269:Ribosomal Proteins / Q000235:genetics*; D013307:Streptomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D012269:Ribosomal Proteins; C031798:ribosomal protein S4; D013307:Streptomycin