Fertility after chemotherapy for testicular cancer.
Disseminated testicular cancer has largely become curable with cisplatin-based chemotherapy. The prospect of fertility after treatment is an important consideration for both patients and clinicians. While there may be an irreversible impairment of spermatogenesis at a cumulative cisplatin dose of greater than 400 mg/m2, a low sperm count does not necessarily appear to prevent fatherhood. This review summarizes currently available data on the effects of chemotherapy on male fertility and steps that can be taken to preserve fertility in this patient population.
Taksey
J
J
Department of Medicine and Urology, Medical University of South Carolina, Charleston, SC 29425, USA.
Bissada
N K
NK
Chaudhary
U B
UB
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy* / Q000503:physiopathology; D013091:Spermatogenesis / Q000187:drug effects; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000503:physiopathology
D002945:Cisplatin