[Correlation between prognosis and the expression of eukaryotic translation initiation factor 4E in surgical margin specimen of laryngeal squamous cell carcinoma].
OBJECTIVE
To reveal the correlation between prognosis and the expression of eIF4E in the pathological negative surgical margin patients of laryngeal squamous cell carcinoma (SCC).


METHODS
Immunohistochemistry was used to detect the expression of eIF4E protein in the pathological negative margin specimen and primary site of cancer of 67 patients, and 5 year survival rate data of those patients was analyzed retrospectively.


RESULTS
The positive expression rate of eIF4E protein in surgical margin and primary site of cancer was 32.8% (22/67) and 100% (67/67) respectively. As for the control group, in which the eIF4E protein expression was not be found. The local recurrence rate was 63.6% for patients with eIF4E positive margin and 28.9% for patients with eIF4E negative margin (P = 0.006). The 5-year survival rate of patients with eIF4E positive margin was lower than those with negative margin (43.31% vs 77.52%, P = 0.0006).


CONCLUSIONS
The prognosis of patients with eIF4E protein positive expression in the pathological negative surgical margin may be worse than those of the negative.
Xia
Liang-ping
LP
Department of Head and Neck Surgery, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.
Xu
Guang-pu
GP
Zeng
Zong-yuan
ZY
Rao
Hui-lan
HL
Zeng
Jing
J
Hou
Jing-hui
JH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D039561:Eukaryotic Initiation Factor-4E / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
D039561:Eukaryotic Initiation Factor-4E