title: The effects of endurance exercise and vitamin E on oxidative stress in the elderly.
abstract: To examine the effects of exercise and vitamin E supplementation on oxidative stress in older adults, 59 participants, age 76.3 +/- 4.2 years, were randomly assigned to 1 of 4 groups: an exercise group taking placebos (EGP) or vitamin E (EGE) or a sedentary group taking placebos (SGP) or vitamin E (SGE). Measures included weight, VO2max, blood pressure (BP), and serum concentrations of vitamin E and lipid hydroperoxide (LOOH). At the end of the 16-week trial, the EGP and EGE had significant increases in VO2max and significant decreases in resting BP, weight, and LOOH concentrations (P < 0.05). The SGE had significant decreases in LOOH and BP (P < 0.05). There were no significant changes in the SGP (P > 0.05). The results suggest that endurance exercise in combination with vitamin E reduces oxidative stress, improves aerobic fitness, and reduces BP and weight in older adults. Even sedentary participants who take vitamin E may reduce oxidative stress and lower BP.
authors.affiliation: University of Florida, College of Nursing, Box 100187, Gainesville, FL 32610-0187, USA. jessujv@nursing.ufl.edu
authors.forename: James V
authors.initials: JV
authors.lastname: Jessup
authors.forename: Claydell
authors.initials: C
authors.lastname: Horne
authors.forename: Hossein
authors.initials: H
authors.lastname: Yarandi
authors.forename: John
authors.initials: J
authors.lastname: Quindry
mesh_terms: D000368:Aged / Q000502:physiology*; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003131:Combined Modality Therapy; D005080:Exercise Test; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006339:Heart Rate; D006801:Humans; D016014:Linear Models; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology*; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D010807:Physical Endurance / Q000187:drug effects* / Q000502:physiology*; D010809:Physical Fitness / Q000502:physiology; D016896:Treatment Outcome; D014810:Vitamin E / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D014810:Vitamin E