title: [Correlation between prognosis and the expression of eukaryotic translation initiation factor 4E in surgical margin specimen of laryngeal squamous cell carcinoma].
abstract: OBJECTIVE
  To reveal the correlation between prognosis and the expression of eIF4E in the pathological negative surgical margin patients of laryngeal squamous cell carcinoma (SCC).
  
  
  METHODS
  Immunohistochemistry was used to detect the expression of eIF4E protein in the pathological negative margin specimen and primary site of cancer of 67 patients, and 5 year survival rate data of those patients was analyzed retrospectively.
  
  
  RESULTS
  The positive expression rate of eIF4E protein in surgical margin and primary site of cancer was 32.8% (22/67) and 100% (67/67) respectively. As for the control group, in which the eIF4E protein expression was not be found. The local recurrence rate was 63.6% for patients with eIF4E positive margin and 28.9% for patients with eIF4E negative margin (P = 0.006). The 5-year survival rate of patients with eIF4E positive margin was lower than those with negative margin (43.31% vs 77.52%, P = 0.0006).
  
  
  CONCLUSIONS
  The prognosis of patients with eIF4E protein positive expression in the pathological negative surgical margin may be worse than those of the negative.
authors.affiliation: Department of Head and Neck Surgery, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.
authors.forename: Liang-ping
authors.initials: LP
authors.lastname: Xia
authors.forename: Guang-pu
authors.initials: GP
authors.lastname: Xu
authors.forename: Zong-yuan
authors.initials: ZY
authors.lastname: Zeng
authors.forename: Hui-lan
authors.initials: HL
authors.lastname: Rao
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
authors.forename: Jing-hui
authors.initials: JH
authors.lastname: Hou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D039561:Eukaryotic Initiation Factor-4E / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D039561:Eukaryotic Initiation Factor-4E