[Effects of SDF-1 alpha and its receptor on regulation of hematopoiesis].
Hematopoietic stem/progenitor cell transplantation is one of main choices for treating patients with malignant tumor or heredity diseases in recently year. The homing of hematopoietic stem cells(HSC) is a committed step to ensure the bone marrow hematopoiesis reconstitution. Recent studies have showed that stromal cell derived factor-1 (SDF-1) and its receptor has important effects on proliferation, differentiation, homing of HSC to bone marrow and hematopoiesis reconstitution. The purpose of this review is to give a recent update informations on mechanism of hematopoiesis regulation mediated by SDF-1 and its receptor.
Fu
J X
JX
Department of Immunology, Biotechnology Institute, Suzhou University, Suzhou 215007, China. uufjxly@public1.sz.js.cn
Zhang
X G
XG
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology*; D019650:Hematopoietic Stem Cell Mobilization; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology; D006801:Humans; D051379:Mice; D019718:Receptors, CXCR4 / Q000502:physiology*
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; C515256:Cxcl12 protein, mouse; D019718:Receptors, CXCR4