title: The 245 kb amplified chromosome of Leishmania (V.) braziliensis contains a biopterin transporter gene.
abstract: Leishmania (V.) braziliensis M2903 presents a small linear and stable 245 kb chromosome originating from a genomic amplification. Similar amplifications present in other species of Leishmania contain a gene coding for a biopterin transporter. Since Leishmania is auxotrophic for this metabolite, this amplification could result from the need to better capture biotpterin from growth media under specific circumstances. In this paper we show that this gene is also present in L. (V.) braziliensis small chromosome, which shares sequences with other genomic amplifications already described.
authors.affiliation: Departamento de Biologia Celular e Genética, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. csampaio@uerj.br
authors.forename: M C R
authors.initials: MC
authors.lastname: Sampaio
authors.forename: Y M
authors.initials: YM
authors.lastname: Traub-Cseko
mesh_terms: D000818:Animals; D001708:Biopterins / Q000235:genetics*; D002875:Chromosomes; D016521:Electrophoresis, Gel, Pulsed-Field; D005784:Gene Amplification; D017125:Genes, Protozoan / Q000235:genetics; D007892:Leishmania braziliensis / Q000235:genetics*
chemical_list: D001708:Biopterins