Minichromosome maintenance 2 expression is correlated with mode of invasion and prognosis in oral squamous cell carcinomas.
BACKGROUND
This study examined the immunohistochemical expression of cell-cycle related molecules as well as cell proliferation and pathologic findings in oral squamous cell carcinoma (SCC) in order to clarify their pathobiologic and prognostic significance.


METHODS
A total of 46 oral SCC specimens were analyzed using Ki-67, minichromosome maintenance 2 (MCM2), p53, p27, p21, and TUNEL. Aspects including tumor differentiation, mode of carcinoma invasion, tumor metastasis, and patient prognosis were compared among the specimens.


RESULTS
A significantly higher MCM2 labeling index (LI) was observed in the moderately differentiated SCCs when compared to the well-differentiated SCCs (P<0.05). The higher MCM2 LI was correlated with mode of invasion Grade 4 (infiltrative growth) and patient prognosis. In contrast, the LIs of Ki-67, TUNEL-signal, p53, p27, and p21 were not correlated with patient prognosis.


CONCLUSIONS
Higher MCM2 LI provides useful information for patient prognosis in oral SCCs.
Kodani
Isamu
I
First Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan. ikodani@grape.med.tottori-u.ac.jp
Osaki
Mitsuhiko
M
Shomori
Kohei
K
Araki
Kunio
K
Goto
Eizo
E
Ryoke
Kazuo
K
Ito
Hisao
H
D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000556:secondary; D018797:Cell Cycle Proteins / Q000032:analysis; D050759:Cyclin-Dependent Kinase Inhibitor p21; D050760:Cyclin-Dependent Kinase Inhibitor p27; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors; D016213:Cyclins / Q000032:analysis; D004261:DNA Replication; D004273:DNA, Neoplasm / Q000032:analysis*; D004791:Enzyme Inhibitors / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D020287:In Situ Nick-End Labeling; D019394:Ki-67 Antigen / Q000032:analysis; D008875:Middle Aged; D064111:Minichromosome Maintenance Complex Component 2; D009062:Mouth Neoplasms / Q000473:pathology*; D009361:Neoplasm Invasiveness; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D025521:Tumor Suppressor Proteins / Q000032:analysis
C493956:CDKN1A protein, human; D018797:Cell Cycle Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D004273:DNA, Neoplasm; D004791:Enzyme Inhibitors; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D018844:Cyclin-Dependent Kinases; D064111:Minichromosome Maintenance Complex Component 2