In vivo gadolinium neutron capture therapy using a potentially effective compound (Gd-BOPTA).
BACKGROUND
In a previous study, we found that Gadobenate dimeglumine (Gd-BOPTA) resulted in a significantly greater Gd uptake by brain tumor tissue than Gadopentate dimeglumine (Gd-DTPA). Therefore, we investigated whether Gd-BOPTA is an efficient agent for neutron capture therapy (NCT).


METHODS
Four groups of Fisher344 rats (control, neutron (n), n+ Gd-DTPA, n+ Gd-BOPTA) were subcutaneously injected 9L gliosarcoma cells in both hind legs. Gd-BOPTA and Gd-DTPA (0.05 mmol/g tumor weight) were injected directly into the tumor. At the peak of Gd uptake, thermal neutron irradiation was applied.


RESULTS
Two Gd+ groups showed pronounced tumor growth delay as compared with the control and neutron groups (p = 0.0053, 0.0064, respectively). Furthermore, the BOPTA group showed significantly prolonged delay of tumor growth as compared to the DTPA group (p = 0.033).


CONCLUSIONS
This is the first report of Gd-NCT to demonstrate that Gd-BOPTA serve as an effective compound for NCT. Better cytocidal effects of Gd-BOPTA warrant further investigation of subcellular Gd distribution.
Matsumura
Akira
A
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. matsumur@md.tsukuba.ac.jp
Zhang
Tian
T
Yamamoto
Tetsuya
T
Yoshida
Fumiyo
F
Sakurai
Yoshinori
Y
Shimojo
Nobuhiro
N
Nose
Tadao
T
D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D019786:Gadolinium DTPA / Q000493:pharmacokinetics / Q000494:pharmacology; D018316:Gliosarcoma / Q000378:metabolism / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D008536:Meglumine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology*; D017247:Neutron Capture Therapy / Q000379:methods*; D009942:Organometallic Compounds / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D019786:Gadolinium DTPA