title: Does neurofilament phosphorylation regulate axonal transport?
abstract: Phosphorylation of neurofilaments has long been considered to regulate their axonal transport rate and, in doing so, to provide stability to mature axons. Interpretation of data recently obtained following C-terminal deletion experiments has prompted a challenge to this hypothesis. We present evidence that these deletion studies remain consistent with, rather than refute, a role for C-terminal phosphorylation in regulation of neurofilament axonal transport.
authors.affiliation: Center for Cellular Neurobiology and Neurodegeneration Research, Departments of Biological Sciences and Biochemistry, University of Massachusetts (Lowell), One University Avenue, Lowell, MA 01854, USA. thomas_shea@uml.edu
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Shea
authors.forename: Cheolwha
authors.initials: C
authors.lastname: Jung
authors.forename: Harish C
authors.initials: HC
authors.lastname: Pant
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D051379:Mice; D016900:Neurofilament Proteins / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000201:enzymology*; D010744:Phosphoric Monoester Hydrolases / Q000187:drug effects*; D010766:Phosphorylation; D021122:Protein Subunits / Q000378:metabolism; D017384:Sequence Deletion
chemical_list: D004791:Enzyme Inhibitors; D016900:Neurofilament Proteins; D021122:Protein Subunits; D010744:Phosphoric Monoester Hydrolases