title: Synthesis of muscothiazoles A and B: Critical role of methyl group substitution in RCM-based syntheses of macrocycles.
abstract: [reaction: see text] Muscothiazoles A (2b) and B (2c) have been prepared by two approaches that differ in the order of assembly of the rings. Comparative studies show that substitution of the carbon chains in substrate 5 or 12 (respective precursors to 13-membered and 14-membered rings by RCM), even by a single methyl group, can have a profound effect on increasing the efficiency of the macrocyclization.
authors.affiliation: Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral St., Glasgow, G1 1XL, United Kingdom.
authors.forename: Aurélien G J
authors.initials: AG
authors.lastname: Commeureuc
authors.forename: John A
authors.initials: JA
authors.lastname: Murphy
authors.forename: Mark L
authors.initials: ML
authors.lastname: Dewis