Kinases in clathrin-mediated endocytosis.
The process of clathrin-coated vesicle (CCV) formation/disassembly has been studied intensively, and numerous proteins have been identified which aid this process. We have learnt a great deal about individual components of the CCV machinery, and now the ultimate aim is to elucidate the mechanisms regulating clathrin-mediated trafficking. One of the fundamental processes governing the complicated network of interactions is phosphorylation. It has been known for some time that several proteins associated with clathrin-coated vesicles are substrates for protein kinases. These proteins include clathrin, three of the four adaptor complex subunits, dynamin 1, synaptojanin 1 and the amphiphysins. However, the identities of the kinases involved in this process remained largely unknown until recently. This short review discusses advances in our knowledge of how CCV formation/disassembly is regulated by the phosphorylation/dephosphorylation cycle and the role played by specific protein kinases in that process.
Korolchuk
V
V
Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK.
Banting
G
G
D000818:Animals; D022163:Clathrin-Coated Vesicles / Q000502:physiology*; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D010766:Phosphorylation; D010770:Phosphotransferases / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism
D033921:Vesicular Transport Proteins; D010770:Phosphotransferases