[Study on the distribution of vitamin D receptor gene start codon polymorphism in the Achangs and Hans].
OBJECTIVE
To detect the difference between the Chinese Achang and Han ethnic groups in Yunnan province in the distribution of vitamin D receptor (VDR) gene start codon polymorphism.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism, gene sequencing and genetic analysis methods were used. A restriction fragment length polymorphism in the start codon of VDR (Fok I) gene was tested in the Achangs (n=68) and the Hans (n=92).


RESULTS
The frequencies of FF, Ff and ff genotypes were found to be 18%, 35% and 47% in the Achangs, and 22%, 52% and 26% in the Hans, respectively. A significant difference was seen in the frequency distribution of VDR genotype between the Achangs and the Hans(Chi2=7.716, P=0.021).


CONCLUSIONS
The Achang and Han ethnic groups differ in the frequency distribution of VDR gene start codon polymorphism.
Li
Ji-mei
JM
Clinical Research Center, the First Affiliated Hospital, Kunming Medical College, Kunming, Yunnan, 650032 PR China.
Lu
Hua-jun
HJ
Li
Hai-lin
HL
Tang
Rui-zhu
RZ
Wang
Xiao-xian
XX
Hao
Ping
P
D002681:China; D018387:Codon, Initiator / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*
D018387:Codon, Initiator; D018167:Receptors, Calcitriol