title: Relation of local platelet glycoprotein IIb/IIIa independent activation during coronary angioplasty in acute myocardial infarction to recovery of left ventricular function.
abstract: We assessed glycoprotein (GP) IIb/IIIa independent platelet activation in coronary sinus and peripheral blood from patients who underwent angioplasty for acute myocardial infarction and stable angina. Despite complete blockade of the activated GP IIb/IIIa receptor with abciximab in patients with acute myocardial infarction, unsuppressed local GP IIb/IIIa independent activation was associated with a lack of recovery of left ventricular function.
authors.affiliation: Alfred Hospital and Baker Medical Research Institute, Prahan, Melbourne, Australia. andrew.taylor@baker.edu.au
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Taylor
authors.forename: Alex
authors.initials: A
authors.lastname: Bobik
authors.forename: Michael C
authors.initials: MC
authors.lastname: Berndt
authors.forename: Victor
authors.initials: V
authors.lastname: Kalff
authors.forename: Alexandra
authors.initials: A
authors.lastname: Michaelides
authors.forename: Garry L R
authors.initials: GL
authors.lastname: Jennings
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease / Q000097:blood / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D015539:Platelet Activation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000502:physiology*; D016277:Ventricular Function, Left
chemical_list: D019039:Platelet Glycoprotein GPIIb-IIIa Complex