Slit-Robo: neuronal guides signal in tumor angiogenesis.
Slit and Roundabout (Robo) are well-characterized for neuron and leukocyte guidance. Their governing roles have now been expanded to control tumor-endothelial cell communication and mediate tumor-induced angiogenesis.
Liu
Zhao Jun
ZJ
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA. herlynm@wistar.upenn.edu
Herlyn
Meenhard
M
D000818:Animals; D029721:Drosophila Proteins; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009474:Neurons / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000502:physiology*; D015398:Signal Transduction; D000097905:Roundabout Proteins
D029721:Drosophila Proteins; D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins; C066819:sli protein, Drosophila