Early amidation approach to 3-[(4-amido)pyrrol-2-yl]-2-indolinones.
A new synthesis of 3-[(4-amido)pyrrol-2-yl]-2-indolinones has been developed, where the amide side chain was installed prior to pyrrole formation. This strategy precludes the need to use any coupling reagents to install the amide side chain. This process includes a zinc-free alternative to the Knorr pyrrole synthesis.
Manley
Jerad M
JM
Chemical Research and Development, Pfizer Inc, 0200-1500-91-201, 7000 Portage Road, Kalamazoo, Michigan 49001, USA.
Kalman
Monica J
MJ
Conway
Brian G
BG
Ball
Cynthia C
CC
Havens
Jeffrey L
JL
Vaidyanathan
Rajappa
R
D000577:Amides / Q000138:chemical synthesis; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D015032:Zinc
D000577:Amides; D007202:Indicators and Reagents; D007211:Indoles; D011758:Pyrroles; D015032:Zinc