title: [Ototoxicity of gentamicin assessed by the vestibular evoked potentials].
abstract: OBJECTIVE
  To assess ototoxicity of gentamicin by the vestibular evoked potentials (VsEPs) and auditory brainstem response (ABR).
  
  
  METHODS
  40 guinea pigs were divided randomly into 4 groups, 10 animals of group A were injected gentamicin intramuscularly 60 mg/(kg.d). 10 of group B were injected Ns intramuscularly 0.5 ml/d as control. 10 of group C were given gentamicin intratympanic 5 mg/d(0.1 ml). 10 of group D were given Ns intratympanic 0.1 ml/d as control. ABR and VsEPs were measured prior to and following the administration.
  
  
  RESULTS
  After treatment group A 21 days, 40 days, group C 5 days, 10 days, ABR and VsEPs showed significant changes, corresponding to histopathological examination of the temporal bones.
  
  
  CONCLUSIONS
  VsEPs used in assessing ototoxicity of gentamicin just as ABR.
authors.affiliation: Department of Otolaryngology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. zidongjiang@263.net
authors.forename: Z
authors.initials: Z
authors.lastname: Jiang
authors.forename: L
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000287:Administration, Topical; D000818:Animals; D007758:Ear, Inner / Q000187:drug effects* / Q000503:physiopathology; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D005839:Gentamicins / Q000008:administration & dosage / Q000633:toxicity*; D006168:Guinea Pigs; D007273:Injections, Intramuscular; D014722:Vestibule, Labyrinth / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D005839:Gentamicins