[Phytoestrogen and cancer prevention].
Phytoestrogens are defined to be plant chemicals that modify estrogenic effects in the body by binding to the estrogen receptors in mammals. Isoflavones, coumestane, lignan, and prenylflavones are examples of these, with isoflavones from soy foods and lignans from rye being a major dietary contribution. Mechanisms of cancer prevention by these phytoestrogens are reviewed, and human epidemiological studies, especially for breast and prostate cancers, are summarized and the results discussed.
Watanabe
Shaw
S
Department of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuraoka, Setagaya-ku, Tokyo 156-8502, Japan.
Uesugi
Sayo
S
Zhuo
XingGang
X
Kimira
Mitsuru
M
D001943:Breast Neoplasms / Q000517:prevention & control*; D004032:Diet; D004968:Estrogens, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D048789:Phytoestrogens; D028321:Plant Preparations; D011471:Prostatic Neoplasms / Q000517:prevention & control*; D012306:Risk; D030262:Soybean Proteins / Q000737:chemistry
D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D017705:Lignans; D048789:Phytoestrogens; D028321:Plant Preparations; D030262:Soybean Proteins