[Study of the gene expression pattern in the Kkay mouse with type 2 diabetes by genomic-scale gene expression analysis].
OBJECTIVE
To study the genes differentially expressed in the liver of Kkay diabetic and normal mice by genomic-scale gene expression analysis.


METHODS
cDNA microarray chips containing 8,192 cDNAs were used to explore the gene expression pattern of Kkay mouse liver.


RESULTS
One hundred and fifty-four genes were screened out, including 68 complete cDNAs and expressed sequence tags, and among them 40 genes were up-regulated and 114 genes were down-regulated respectively.


CONCLUSIONS
Most of the gene expression analysis results were consistent with previous study, and the gene expression pattern of Kkay mouse based on cDNA microarray could be used for high-throughout screening out the genes associated with type 2 diabetes.
Guo
Qing-hua
QH
Endocrinology Department, General Hospital of PLA, Beijing 100853, China.
Lu
Ju-ming
JM
Yin
Ling
L
Pan
Chang-yu
CY
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D015870:Gene Expression; D020869:Gene Expression Profiling; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D012333:RNA, Messenger