title: Developing risk-based target concentrations for carcinogenic polycyclic aromatic hydrocarbon compounds assuming human consumption of aquatic biota.
abstract: As part of the remediation process at a former creosote-handling facility in Washington, target groundwater concentrations were developed as goals for the planned cleanup efforts. Considering state regulatory requirements and site-specific conditions, these concentrations were established to protect surface water in the lake adjacent to the site. These risk-based values were calculated assuming that chemicals will (1) be transported in groundwater, (2) discharge into the lake, and (3) be taken up by aquatic organisms that may be consumed by humans. Among the primary chemicals driving remediation decisions at this site are carcinogenic polycyclic aromatic hydrocarbon (cPAH) compounds, which have limited environmental mobility and are metabolized by many types of potentially edible aquatic organisms. This work included assessing the validity for cPAH compounds of the required default regulatory assumptions and deriving alternative risk-based concentrations. These analyses focused on factors that would modify the generic assumption regarding bioconcentration of cPAH compounds in aquatic biota and influence bioavailability of cPAH compounds to humans consuming the biota. Modifications based on these factors and the use of toxicity equivalency factors resulted in alternative risk-based concentrations for individual cPAH compounds that ranged from approximately 7 to 700 times greater than the default value of 0.03 microg/l.
authors.affiliation: Gradient Corporation, Mercer Island, Washington 98040, USA. cpboyce@gradientcorp.com
authors.forename: Catherine
authors.initials: C
authors.lastname: Petito Boyce
authors.forename: Michael
authors.initials: M
authors.lastname: Garry
mesh_terms: D000818:Animals; D002274:Carcinogens, Environmental / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity; D004781:Environmental Exposure / Q000032:analysis; D004784:Environmental Monitoring / Q000379:methods; D005506:Food Contamination; D006801:Humans; D008452:Maximum Allowable Concentration; D011083:Polycyclic Compounds / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity; D018570:Risk Assessment; D017747:Seafood / Q000009:adverse effects* / Q000145:classification / Q000592:standards; D018505:Waste Management; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity
chemical_list: D002274:Carcinogens, Environmental; D011083:Polycyclic Compounds; D014874:Water Pollutants, Chemical