[Relation of hypertension to diabetic nephropathy in patients with non-insulin-dependent diabetes mellitus--a pair-matched case-control study].
OBJECTIVE
The study aimed to assess the role of hypertension in the cause of nephropathy in patients with NIDDM.


METHODS
A retrospective analysis was done on two groups of non-insulin-dependent diabetes mellitus (NIDDM) patients, one group without proteinuria (< 300 mg/24 h, n = 106) and the other group with proteinuria (> or = 500 mg/24 h, n = 106). The groups were matched by age (< or = +/- 3) years, sex, race, and resident place. Some information of these subjects including demographic, history of disease, family history of diseases, life and behavior style variables were obtained by questionnaire, some variables were measured including systolic blood pressure(SBP), diastolic blood pressure(DBP), fasting blood glucose, and quantity of protein in 24 h urine. Finally the conditional logistic regression analysis was done.


RESULTS
Some factors were independently associated with the occurrence risk of diabetic nephropathy (DN) associated history of hypertension, longer duration of hypertension, higher levels of the past highest SBP and DBP. Their corresponding odd ratios(OR) with 95% confidence intervals(CI) were 2.00(1.17-3.43), 1.25(1.08-1.46), 1.38(1.15-1.66), and 1.33(1.09-1.62) respectively. But family history of hypertension was not significantly associated with the development of DN. When the above-mentioned relations were adjusted by some relevant confounding factors, the associations were still present.


CONCLUSIONS
History and longer duration of hypertension, history of the highest SBP and DBP are independent risk factors for DN.
Hou
X H
XH
Department of Epidemiology, Tianjin Medical University, Tianjin 300070, China.
Wang
J H
JH
Feng
P
P
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003928:Diabetic Nephropathies / Q000209:etiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors