title: Review of the use of neuraminidase inhibitors for prophylaxis of influenza.
abstract: Influenza causes significant morbidity and mortality particularly in vulnerable population groups. Although vaccination is recommended as the primary method of preventing influenza, antiviral drugs may play a complementary role. The National Institute for Clinical Effectiveness (NICE) has recently published guidance on the use of anti-viral drugs in the treatment of influenza, and further guidance on their use for prophylaxis is expected later in the year. In anticipation of this guidance this paper reviews the evidence for the effectiveness of the prophylactic use of neuraminidase inhibitors. Results of this review show that neuraminidase inhibitors are effective in preventing laboratory-confirmed clinical influenza in healthy adults, both when used as post-exposure prophylaxis for close and household contacts, and as seasonal prophylaxis in the wider community. Direct evidence in the elderly and institutions is too limited to draw firm conclusions about their effectiveness in that setting. However it seems probable that neuraminidase inhibitors would also be effective in these groups.
authors.affiliation: Health Protection Agency, Communicable Disease Surveillance Centre, 61 Colindale Avenye, London NW9 5EQ. hilary.kirkbride@hpa.org.uk
authors.forename: H A
authors.initials: HA
authors.lastname: Kirkbride
authors.forename: J
authors.initials: J
authors.lastname: Watson
mesh_terms: D000081:Acetamides / Q000627:therapeutic use; D000547:Amantadine / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006146:Guanidines; D006285:Health Planning; D006801:Humans; D007251:Influenza, Human / Q000517:prevention & control*; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D053139:Oseltamivir; D017410:Practice Guidelines as Topic; D011714:Pyrans; D012299:Rimantadine / Q000627:therapeutic use; D012794:Sialic Acids / Q000627:therapeutic use; D053243:Zanamivir
chemical_list: D000081:Acetamides; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D006146:Guanidines; D011714:Pyrans; D012794:Sialic Acids; D012299:Rimantadine; D053139:Oseltamivir; D000547:Amantadine; D009439:Neuraminidase; D053243:Zanamivir