title: The effect of oil as a dietary component on in vitro dissolution of an acid-labile drug.
abstract: The non-benzodiazepine-like anxiolytic agent deramiclane fumarate (EGIA-3886) was used to demonstrate that the presence of high oil/fat content in dissolution media serves as a barrier against accelerated drug degradation in acidic media.
authors.affiliation: Research & Development Directorate, EGIS Pharmaceuticals Ltd., Budapest, Hungary. clindev.rd@egis.hu
authors.forename: S
authors.initials: S
authors.lastname: Al-Behaisi
authors.forename: I
authors.initials: I
authors.lastname: Antal
authors.forename: G
authors.initials: G
authors.lastname: Morovján
authors.forename: S
authors.initials: S
authors.lastname: Marton
authors.forename: I
authors.initials: I
authors.lastname: Klebovich
mesh_terms: D014151:Anti-Anxiety Agents / Q000737:chemistry*; D002138:Calibration; D001892:Camphanes / Q000737:chemistry*; D004042:Dietary Fats, Unsaturated / Q000032:analysis*; D012995:Solubility; D013608:Tablets, Enteric-Coated; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D001892:Camphanes; D004042:Dietary Fats, Unsaturated; D013608:Tablets, Enteric-Coated; C060555:deramciclane