title: Prior knowledge for time domain quantification of in vivo brain or liver 31P MR spectra.
abstract: Prior knowledge is required when quantifying in vivo (31)P magnetic resonance spectra from the brain or liver. The prior knowledge system we have used models both the phosphomonoester and phosphodiester resonances as two peaks of equal linewidth and fixed relative chemical shift. The analysis of the data is carried out in the time domain, which allows the broad component of the spectra to be modelled. This prior knowledge method has been tested for analysis of in vivo (31)P MR spectra from the liver and brain and gives results consistent with other methods that are also used to analyse the spectra, but with reduced variability. This technique may be utilized for studies requiring serial MR spectroscopy examinations, before and after patient treatment.
authors.affiliation: Robert Steiner MR Unit, Imaging Sciences Department, MRC Clinical Sciences Centre Imperial College London, London, UK. g.hamilton@ic.ac.uk
authors.forename: Gavin
authors.initials: G
authors.lastname: Hamilton
authors.forename: Nayna
authors.initials: N
authors.lastname: Patel
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Forton
authors.forename: Joseph V
authors.initials: JV
authors.lastname: Hajnal
authors.forename: Simon D
authors.initials: SD
authors.lastname: Taylor-Robinson
mesh_terms: D000465:Algorithms; D001923:Brain Chemistry; D003198:Computer Simulation; D006801:Humans; D008099:Liver / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D015233:Models, Statistical; D017553:Phosphorus Compounds / Q000032:analysis*; D010759:Phosphorus Isotopes; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D017553:Phosphorus Compounds; D010759:Phosphorus Isotopes