Estrogen receptor alpha gene polymorphisms and breast cancer risk.
We conducted a hospital-based case-control study to evaluate the association between the XbaI and PvuII restriction fragment length polymorphisms (RFLPs) in intron I of the estrogen receptor alpha (ER alpha) gene and breast cancer risk. The study population consisted of 205 histologically confirmed incident breast cancer cases and 205 age-matched controls with no present and previous history of cancer. The PvuII genotype distribution did not show any difference between cases and controls, but the adjusted odds ratio (OR) for the XbaI X allele containing genotypes was 0.4 (95% CI: 0.3-0.6) compared with the xx genotype. The decrease in the OR appeared to be more attributable to the postmenopausal women; the ORs were 0.3 (95% CI: 0.1-0.5) and 0.5 (95% CI: 0.3-0.9) for postmenopausal and premenopausal women, respectively. Our results therefore suggest that the ER alpha XbaI polymorphism modifies individual susceptibility to breast cancer in Korean women.
Shin
Aesun
A
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Kang
Daehee
D
Nishio
Hisahide
H
Lee
Myeong Jin
MJ
Park
Sue Kyung
SK
Kim
Sook-Un
SU
Noh
Dong-Young
DY
Choe
Kuk-Jin
KJ
Ahn
Se-Hyun
SH
Hirvonen
Ari
A
Kim
Ju Han
JH
Yoo
Keun-Young
KY
D000328:Adult; D000368:Aged; D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D047628:Estrogen Receptor alpha; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D016017:Odds Ratio; D012150:Polymorphism, Restriction Fragment Length; D011960:Receptors, Estrogen / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors
D047628:Estrogen Receptor alpha; D011960:Receptors, Estrogen