title: Unstructured model for L-lysine fermentation under controlled dissolved oxygen.
abstract: An unstructured model was developed for batch cultivation of Corynebacterium lactofermentum (ATCC 21799) under controlled dissolved oxygen. The model is capable of predicting batch experiments performed at various initial substrate concentrations. By extending the batch culture model to a fed-batch model and using a heuristic approach to optimize the fed-batch cultivation, it is shown that fed-batch cultivation is superior to batch operation due to increased productivity at high substrate concentrations.
authors.affiliation: Biotechnology Development, Schering-Plough Research Institute, 1011 Morris Avenue, U-14-2-20, Union, New Jersey 07083, USA. semsi.ensari@spcorp.com
authors.forename: Semsi
authors.initials: S
authors.lastname: Ensari
authors.forename: Joon Ha
authors.initials: JH
authors.lastname: Kim
authors.forename: Henry C
authors.initials: HC
authors.lastname: Lim
mesh_terms: D019149:Bioreactors / Q000382:microbiology*; D003198:Computer Simulation; D003352:Corynebacterium / Q000254:growth & development* / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D008239:Lysine / Q000096:biosynthesis*; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D005947:Glucose; D008239:Lysine; D010100:Oxygen