Sox15 is up regulated in the embryonic mouse testis.
The mammalian sex determining region on the Y chromosome, SRY, is the founding member of the SOX gene family. SOX genes share a common DNA-binding motif termed the HMG box and have diverse roles in vertebrate embryonic development and tissue differentiation. Sox15 expression was analysed during mouse embryogenesis by whole-mount in situ hybridisation and Real Time RT-PCR. Sox15 was found to be expressed in developing mouse gonads from 11.5 dpc to 13.5 dpc with a peak of expression at 12.5 dpc. Expression was approximately twice as high in the male gonad as in the female gonad.
Sarraj
Mai A
MA
Department of Paediatrics, Centre for Hormone Research, Murdoch Children's Research Institute, Royal Children's Hospital, University of Melbourne, Melbourne, Vic 3052, Australia.
Wilmore
Helen P
HP
McClive
Peter J
PJ
Sinclair
Andrew H
AH
D000818:Animals; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006609:High Mobility Group Proteins / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D051379:Mice; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055747:SOX Transcription Factors; D055758:SOX9 Transcription Factor; D013737:Testis / Q000196:embryology*; D014157:Transcription Factors / Q000378:metabolism*; D015854:Up-Regulation
D006609:High Mobility Group Proteins; D055747:SOX Transcription Factors; D055758:SOX9 Transcription Factor; C080886:Sox15 protein, mouse; C527933:Sox9 protein, mouse; D014157:Transcription Factors