Recognition of DNA mismatch structures.
A dimeric form of 2-amino-1,8-naphthyridine strongly binds to a G-G mismatch by a zigzag intercalation. To gain insight into the mode of recognition for the G-G mismatch, we have synthesized a series of naphthyridine-heterocycle hybrids and evaluated the binding to G-G mismatches. Furthermore, assuming the G-G mismatch as a special variant of the G-X mismatch where X is G, A, and T, a general scheme for the zigzag binding of naphthyridine-heterocycle hybrids to a G-X mismatch was discussed. These structure activity relationships indicate that the zigzag binding of naphthyridine-heterocycle hybrids to a G-X mismatch could be deduced in a two-step sequence.
Hagihara
Shinya
S
Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 606-8501, Japan.
Nakatani
Kazuhiko
K
Saito
Isao
I
D020137:Base Pair Mismatch; D004247:DNA / Q000737:chemistry*; D009287:Naphthyridines / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D013329:Structure-Activity Relationship
C427025:2-amino-1,8-naphthyridine; D009287:Naphthyridines; D004247:DNA