The final player in the coenzyme A biosynthetic pathway.
The determination of the crystal structure of human phosphopantothenoylcysteine synthetase completes our knowledge of the enzyme structures involved in all steps of coenzyme A biosynthesis. This structure provides insight into the differences between bacterial and mammalian forms of the enzyme and may guide the structure-based development of novel antibacterial compounds.
O'Toole
Nicholas
N
Biotechnology Research Institute, NRC, 6100 Royalmount Avenue, Montréal, Québec H4P 2R2, Canada.
Cygler
Miroslaw
M
D003065:Coenzyme A / Q000096:biosynthesis*; D018360:Crystallography, X-Ray; D019281:Dimerization; D004926:Escherichia coli / Q000201:enzymology; D006801:Humans; D010453:Peptide Synthases / Q000737:chemistry* / Q000235:genetics; D020836:Protein Structure, Quaternary; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
D010453:Peptide Synthases; C022374:phosphopantothenoyl-cysteine synthetase; D003065:Coenzyme A