[Relationship of the expression of CD44v6 and paxillin to the prognosis of non-small cell lung carcinoma].
OBJECTIVE
To investigate the expression and significance of CD44v6 and Paxillin in non-small cell lung carcinoma.


METHODS
Immunohistochemical staining was used to detect the expression of CD44v6 and Paxillin in 79 cases of non-small cell lung carcinoma, and the relationships of the expression with histological type, lymph node metastasis and prognosis were detected.


RESULTS
The expression rates of CD44v6 and Paxillin were 60.8% and 34.1% respectively. The expression of CD44v6 was positively correlated with metastasis and negatively correlated with the 2-year survival rate (P < 0.05). The expression of Paxillin was positively correlated with metastasis (P < 0.05).


CONCLUSIONS
The expression of CD44v6 and Paxillin is closely correlated with the lymph node metastasis and the prognosis of non-small cell lung carcinoma.
Zuo
Wanli
W
Department of Respiratory Disease, Jiangmen City Central Hospital, Guangzhou 529000, China.
Li
Haigang
H
D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry* / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000032:analysis; D003598:Cytoskeletal Proteins / Q000032:analysis* / Q000096:biosynthesis; D005260:Female; D006023:Glycoproteins / Q000032:analysis* / Q000096:biosynthesis; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis* / Q000096:biosynthesis; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry* / Q000378:metabolism; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D051419:Paxillin; D010750:Phosphoproteins / Q000032:analysis* / Q000096:biosynthesis; D011379:Prognosis
C112697:CD44v6 antigen; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D006023:Glycoproteins; D018960:Hyaluronan Receptors; C496061:PXN protein, human; D051419:Paxillin; D010750:Phosphoproteins