title: An unusual case of CV junction tuberculosis presenting with quadriplegia.
abstract: METHODS
  Isolated tubercular involvement of craniovertebral junction in a human immunodeficiency virus-positive patient causing paraplegia and sudden death with radiologic features is presented.
  
  
  OBJECTIVE
  Isolated involvement of craniovertebral junction by tuberculosis causing quadriparesis is a rare entity. The role of imaging features is presented in diagnosis of craniovertebral junction tuberculosis, which is a treatable disease. Early detection of this entity with prompt treatment can prevent a fatal outcome.
  
  
  BACKGROUND
  Tuberculosis of the cervical spine is a rare and potentially dangerous manifestation of extrapulmonary tuberculosis. The incidence is probably less than 1% of all cases of spinal tuberculosis. However, in the developing countries this constitutes an increasingly important cause of craniovertebral junction instability and cervicomedullary compression. Most of the patients present with pain in the neck and local tenderness. Neurologic deficits of varying degrees have been reported in 24-40% of cases of craniovertebral junction tuberculosis. Quadriplegia followed by sudden death is exceptional (as seen in our case). The incidence of craniovertebral junction tuberculosis in immunocompromised patients is not known. Dramatic recovery is possible if craniovertebral junction tuberculosis is detected early in its course. Prompt medical and surgical treatment may avert a potential catastrophic event in such cases. Imaging methods such as computed tomography and magnetic resonance imaging are diagnostic of this condition and aid in the detection and prompt treatment of the same.
  
  
  METHODS
  Frontal radiograph of the cervical spine and chest, and lateral view of cervical spine followed by plain and contrast enhanced computed tomography scan of the cervical spine was performed to detect the lesion.
  
  
  RESULTS
  These radiographic features were correlated with the clinical findings. The computed tomography findings of bone destruction, prevertebral and extradural peripherally enhancing soft tissue and infiltrating opacities in the lung apexes were consistent with tuberculosis.
  
  
  CONCLUSIONS
  The computed tomography findings described in this report are very specific for tuberculosis of the craniovertebral junction. Clinical and radiologic correlation could help in making the early diagnosis and prompt treatment possible.
authors.affiliation: Department of Radiology, K.E.M. Hospital, Parel Mumbai, India. abhijitaraut@hotmail.com
authors.forename: Abhijit A
authors.initials: AA
authors.lastname: Raut
authors.forename: Ranjeet S
authors.initials: RS
authors.lastname: Narlawar
authors.forename: Arpit
authors.initials: A
authors.lastname: Nagar
authors.forename: Nadeem
authors.initials: N
authors.lastname: Ahmed
authors.forename: Priya
authors.initials: P
authors.lastname: Hira
mesh_terms: D000328:Adult; D001270:Cervical Atlas / Q000000981:diagnostic imaging; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging* / Q000473:pathology; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006679:HIV Seropositivity / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D009777:Occipital Bone / Q000000981:diagnostic imaging; D011782:Quadriplegia / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging; D014399:Tuberculosis, Spinal / Q000150:complications / Q000175:diagnosis* / Q000473:pathology