[Weekly cyclophosphamide pulse therapy combined with corticosteroids in the treatment of pemphigus].
OBJECTIVE
To investigate the better regimen of combined cyclophosphamide pulse therapy with corticosteroids in the treatment of Pemphigus.


METHODS
Intravenous cyclophosphamide was given weekly in a dosage of 600 mg to those Pemphigus patients whose conditions couldn't be improved by corticosteroids (oral prednisone 1.2-1.5 mg/kg/d) alone.


RESULTS
Ten patients with Pemphigus received weekly cyclophosphamide therapy in addition to corticosteroid. Patients conditions improved quickly, without side effects.


CONCLUSIONS
Cyclophosphamide weekly pulse therapy combined with corticosteroids is a good regimen in the treatment of Pemphigus.
Jia
G Q
GQ
Department of Clinical Research, Institute of Dermatology, CAMS, PUMC, Nanjing 210042, China.
Chen
Z Q
ZQ
Li
H L
HL
Cui
P G
PG
Xu
W Y
WY
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D007275:Injections, Intravenous; D010392:Pemphigus / Q000188:drug therapy*; D020551:Pulse Therapy, Drug; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide