title: Effects of aminoglycoside antibiotics on renal antioxidants, malondialdehyde levels, and some serum biochemical parameters.
abstract: Effects of amikacin, gentamicin, kanamycin, and streptomycin on renal tissue superoxide dismutase, glutathione peroxidase, glutathione and malondialdehyde, serum creatinine, potassium, sodium, total protein, glucose, uric acid, and total bilirubin levels were investigated. All aminoglycoside antibiotics decreased renal tissue glutathione levels.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, Konya, Turkey. eyazar@selcuk.edu.tr
authors.forename: Enver
authors.initials: E
authors.lastname: Yazar
authors.forename: Muammer
authors.initials: M
authors.lastname: Elmas
authors.forename: Vahdettin
authors.initials: V
authors.lastname: Altunok
authors.forename: Abdullah
authors.initials: A
authors.lastname: Sivrikaya
authors.forename: Esma
authors.initials: E
authors.lastname: Oztekin
authors.forename: Yavuz Osman
authors.initials: YO
authors.lastname: Birdane
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism*; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D003404:Creatinine / Q000097:blood; D005979:Glutathione Peroxidase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D011188:Potassium / Q000097:blood; D011897:Random Allocation; D012964:Sodium / Q000097:blood; D013482:Superoxide Dismutase / Q000378:metabolism; D014527:Uric Acid / Q000097:blood
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001786:Blood Glucose; D001798:Blood Proteins; D014527:Uric Acid; D008315:Malondialdehyde; D012964:Sodium; D003404:Creatinine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001663:Bilirubin; D011188:Potassium