[Statistical approaches to gene mapping of human diseases].
Gene Mapping of human diseases, especially the complex genetic diseases, has been the difficulty and hotspot in medical genetics and gene study. In this article, the principle and application of several gene mapping methods are discussed, including linkage analysis (parametric and nonparametric linkage analysis), association study and linkage disequilibrium analysis.
Sun
H X
HX
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS, PUMC, Beijing 100005, China.
Fang
F D
FD
D002874:Chromosome Mapping / Q000379:methods*; D005819:Genetic Markers; D005828:Genetics, Population; D006801:Humans; D016013:Likelihood Functions; D015810:Linkage Disequilibrium; D008126:Lod Score; D019655:Quantitative Trait, Heritable; D013223:Statistics as Topic / Q000379:methods*
D005819:Genetic Markers