title: Ets-1 expression is associated with cranial neural crest migration and vasculogenesis in the chick embryo.
abstract: The transcription factor Ets-1 is expressed in many different migratory cell types, suggesting that it may play an important role in regulating motility. To determine whether its expression in the neural crest is consistent with such a function, we have performed a detailed analysis of its expression during early chick embryogenesis. Our results show that this transcription factor is up-regulated in the cranial neural folds and dorsal neural tube approximately 4-6 h prior to commencement of neural crest migration. c-Ets-1 continues to be expressed by migrating cranial neural crest cells and subsequently by some neural crest-derived tissues. In addition to neural crest, we find expression of c-Ets-1 in endothelial cells of blood vessels, in somitic and intermediate mesoderm, in limb buds and in the heart.
authors.affiliation: Department of Cell and Neurobiology, University of Southern California, Keck School of Medicine, 1333 San Pablo Street, BMT 401, Los Angeles, CA 90089, USA.
authors.forename: Siroun A
authors.initials: SA
authors.lastname: Tahtakran
authors.forename: Mark A J
authors.initials: MA
authors.lastname: Selleck
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D002642:Chick Embryo; D002645:Chickens; D003391:Cranial Nerves / Q000098:blood supply / Q000166:cytology / Q000196:embryology; D005314:Embryonic and Fetal Development; D018507:Gene Expression Regulation, Developmental; D009432:Neural Crest / Q000098:blood supply* / Q000196:embryology*; D050784:Proto-Oncogene Protein c-ets-1; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D050784:Proto-Oncogene Protein c-ets-1; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors