[Structural-geometric changes of the myocardium and the state of central hemodynamics during left ventricular remodeling after myocardial infarction].
Intergroup analysis of parameters of central hemodynamics in the process of increase of left ventricular dimensions has shown that changes of pump function of the heart correspond to stages of left ventricular remodeling after myocardial infarction. Decreases of ejection fraction and cardiac output occur in patients with postinfarction aneurysm. At various stages of pathogenesis of remodeling multiple factors facilitate adaptation to novel conditions of functioning. They include structural reorganization of ventricular wall, hypertrophy of myocytes, and augmentation of muscular mass without wall thickening (exocentric hypertrophy). At other equal conditions characteristic for the patients studied starting point of maladaptational left ventricular remodeling and consequent development of cardiac failure can be value of left ventricular diastolic volume 182.7+/-3.28 ml. This volume according to data obtained by the authors represents a threshold over which 'rescue' for the body Staring law is not able to maintain adequate stroke volume and cardiac output.
Belov
Iu V
IuV
Varaksin
V A
VA
D000208:Acute Disease; D000328:Adult; D000368:Aged; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006984:Hypertrophy / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology*; D013997:Time Factors; D020257:Ventricular Remodeling / Q000502:physiology*