title: Synthetic studies on nonthrombogenic biomaterials 14: synthesis and characterization of poly(ether-urethane) bearing a Zwitterionic structure of phosphorylcholine on the surface.
abstract: A new Zwitterionic compound of the phosphorylcholine analogue, 4-hydroxylbutyl phosphorylcholine (HBPC), was synthesized and characterized. HBPC was chemically tethered onto the surface of poly(ether-urethane) (PEU) films with hexamethylene diisocyanate (HDI) as a coupling agent. The existence of a phosphorylcholine structure on the PEU surface was demomstrated by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FT-IR), X-ray photoelectron spectroscopy (XPS) and water contact angle measurements. The nonthrombogenicity of the modified films was evaluated by platelet-rich plasma (PRP) assay. The results showed that films grafted with HBPC have excellent platelet adhesion resistance.
authors.affiliation: Research Center of Surface Interface Science and Technology, Nanjing University, Nanjing 210093, P.R. China.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Yang
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Yuan
authors.forename: J
authors.initials: J
authors.lastname: Shen
authors.forename: S C
authors.initials: SC
authors.lastname: Lin
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D010767:Phosphorylcholine / Q000737:chemistry*; D010974:Platelet Aggregation; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000737:chemistry*; D013499:Surface Properties; D013927:Thrombosis
chemical_list: D001672:Biocompatible Materials; D011140:Polyurethanes; D010767:Phosphorylcholine