Effect of ethanolic extract of Khaya senegalensis on some biochemical parameters of rat kidney.
The effect of administration of ethanolic extract of Khaya senegalensis (2mg/kg body weight) on some biochemical parameters of rat kidney were investigated. Experimental animals were randomly divided into the control, those administered with the extract for 6 days and those administered with extract for 18 days, respectively. The prolonged administration of the extract resulted in significant reduction in the alkaline phosphatase activities of the kidney and its body weight ratio (P<0.05). In contrast, the same prolonged administration of the extract resulted in significant increase in the serum sodium ion concentration (P<0.05) while there was no significant difference in serum potassium ion concentration when compared to control (P>0.05). Administration of the extract for 6 days produced no significant difference from the control values in all the parameters investigated except in serum urea concentration which produced a significant increase (P<0.05). The available evidence in this study suggest that the ethanolic extract of Khaya senegalensis exerted more deleterious effect on the kidney when administered continuously over a prolonged period than a short one and this will adversely affect the functioning of the kidney.
Adebayo
Joseph O
JO
Department of Physiology and Biochemistry, Faculty of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Yakubu
Musa T
MT
Egwim
Evans C
EC
Owoyele
Victor B
VB
Enaibe
Bernard U
BU
D000284:Administration, Oral; D000469:Alkaline Phosphatase / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D006955:Hypernatremia / Q000139:chemically induced; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D029582:Meliaceae; D009549:Nigeria; D009929:Organ Size / Q000187:drug effects; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage* / Q000009:adverse effects*; D051381:Rats; D013997:Time Factors; D014508:Urea / Q000097:blood
D010936:Plant Extracts; D000431:Ethanol; D014508:Urea; D000469:Alkaline Phosphatase