title: [Radiation sensitivity testing and late neurological complications following radiosurgery for AVM: the use of SF2 from fibroblasts as a predictive factor].
abstract: OBJECTIVE
  To identify SF2 as a prognostic factor of late complications from radiosurgery in patients treated for AVM.
  
  
  METHODS
  Five patients with AVM treated in three canadian institutions and who suffered clinically significant neurological sequelaes secondary to radiosurgery were identified. Their fibroblasts were cultured and their radiation sensitivity tested to determine the SF2 for each patient.
  
  
  RESULTS
  Patients who developed a neurological complication from radionecrosis, secondary to radiosurgery had an SF2 different than the two control patients with AVM and no complications and also from a group of five cancer patients without late radiation complications (P = 0.005).
  
  
  CONCLUSIONS
  Radiosurgery is an elective procedure. The identification of a subgroup of patients who are radiosensitive and at a higher risk of radiation induced complications can allow the treatment team to reduce the risk of such complications. SF2 as a new predictive factor should be incorporated in predictive models of risk from treatment of AVM by radiosurgery. This work needs to be confirmed in a larger cohort of patients.
authors.affiliation: Département de radio-oncologie, centre de cancérologie d'Ottawa, 503 Smyth, Ottawa, K1H 1C4, Ontario, Canada. smalone@orcc.on.ca
authors.forename: S
authors.initials: S
authors.lastname: Malone
authors.forename: J
authors.initials: J
authors.lastname: Szanto
authors.forename: G
authors.initials: G
authors.lastname: Alsbeith
authors.forename: E
authors.initials: E
authors.lastname: Szumacher
authors.forename: L
authors.initials: L
authors.lastname: Souhami
authors.forename: R
authors.initials: R
authors.lastname: Gray
authors.forename: A
authors.initials: A
authors.lastname: Girard
authors.forename: P
authors.initials: P
authors.lastname: Raaphorst
authors.forename: L
authors.initials: L
authors.lastname: Grimard
mesh_terms: D002470:Cell Survival; D005347:Fibroblasts; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery*; D009336:Necrosis; D011237:Predictive Value of Tests; D011379:Prognosis; D011832:Radiation Injuries / Q000209:etiology*; D011836:Radiation Tolerance; D016634:Radiosurgery / Q000009:adverse effects*