[Correlation of Helicobacter pylori infection with symptoms and gastric electrical activity in functional dyspepsia].
OBJECTIVE
To investigate correlation of Helicobacter pylori (Hp) infection with symptoms and gastric electrical activity in patients with functional dyspepsia (FD).


METHODS
Sixty patients with FD confirmed by gastroscopy and pathology were enrolled in this study. Of them, 30 Hp positive (Hp+) and 30 Hp negative (Hp-). Ten dyspeptic symptoms were scored according to severity (0-3) and frequency (0-3), including abdominal bloating, abdominal pain, nausea, vomiting, early satiety, heartburn, and so on. Digitrapper EGG was used for recording 30 min during fasting and 60 min after a test meal (1890 kJ, C:F:P = 3.9:3.4:1).


RESULTS
(1) The total symptom score (TSS) was 26.57 +/- 9.16 and 24.37 +/- 6.86 in Hp+ and Hp- groups respectively (NS). There was no significance of each symptom score between both groups, except the score of heartburn in Hp+ were higher than in Hp- group (2.30 +/- 2.04 vs 1.13 +/- 1.78, P < 0.05). (2) The percentage of normal EGG rhythm (2.4-3.7 cpm) was (64.80 +/- 4.74)% in fasting and (55.84 +/- 4.71)% in postprandial stage in Hp+ group and (64.89 +/- 5.04)%, (62.72 +/- 4.57)% in Hp- group. There was no significance of the percentage of normal EGG rhythm, power ratio(PR), and dominant frequency(DF) between HP+ and HP- groups. (3) However, there was close negative correlation of TSS with normal rhythm in postprandial stage in Hp+ group (r = 0.41, P < 0.05).


CONCLUSIONS
There may be different pathophysiologic basis in FD with or without Hp infection. Hp infection may influence postprandial gastric electrical activity. Further study needs to be investigated.
Zhang
L
L
Department of Gastroenterology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Fang
X
X
Ke
M
M
Wang
Z
Z
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004415:Dyspepsia / Q000382:microbiology / Q000503:physiopathology*; D004594:Electrophysiology; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged