title: Outcome of surgical treatment in familial mesial temporal lobe epilepsy.
abstract: OBJECTIVE
  To describe postoperative outcome in patients with familial mesial temporal lobe epilepsy (FMTLE).
  
  
  METHODS
  We studied FMTLE patients who underwent surgical treatment for refractory seizures. FMTLE was defined when at least two individuals in a family had a clinical EEG diagnosis of MTLE. Preoperative investigation included magnetic resonance imaging (MRI), interictal/ictal EEGs, and neuropsychological evaluation. We used Engel's classification for postoperative outcome.
  
  
  RESULTS
  To date, 20 FMTLE patients have been operated on, with 1.6 to 9.8 years of follow-up (mean, 5.5 years). Hippocampal atrophy (HA) and other signs of mesial temporal sclerosis (MTS) were present in 18 patients (15 unilateral). Seizures were recorded in 19 patients. Seventeen (85%) patients are in class I. Two patients had normal hippocampal volumes (HcV): one (5%) is in class II and the other (5%) in class IV (extratemporal seizures developed after surgery). One (5%) patient had bilateral HA and is in class III. Qualitative histopathology showed MTS with different degrees of severity.
  
  
  CONCLUSIONS
  Refractory FMTLE patients have good surgical outcome when unilateral or clearly asymmetric HA is identified. Preoperative investigation should be the same as that in patients with sporadic refractory MTLE.
authors.affiliation: Department of Neurology, University of Campinas, UNICAMP, Campinas, SP, Brazil.
authors.forename: Eliane
authors.initials: E
authors.lastname: Kobayashi
authors.forename: Maria Daniela
authors.initials: MD
authors.lastname: D'Agostino
authors.forename: Iscia
authors.initials: I
authors.lastname: Lopes-Cendes
authors.forename: Eva
authors.initials: E
authors.lastname: Andermann
authors.forename: François
authors.initials: F
authors.lastname: Dubeau
authors.forename: Carlos A M
authors.initials: CA
authors.lastname: Guerreiro
authors.forename: André A
authors.initials: AA
authors.lastname: Schenka
authors.forename: Luciano S
authors.initials: LS
authors.lastname: Queiroz
authors.forename: André
authors.initials: A
authors.lastname: Olivier
authors.forename: Fernando
authors.initials: F
authors.lastname: Cendes
authors.forename: Frederick
authors.initials: F
authors.lastname: Andermann
mesh_terms: D000328:Adult; D000679:Amygdala / Q000473:pathology / Q000601:surgery; D038481:Anterior Temporal Lobectomy; D001284:Atrophy; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome