title: Gastric myoelectrical activity in patients with recurrent gastric or duodenal ulcers.
abstract: The aim of this study was to characterize gastric myoelectrical activity in patients with recurrent gastric ulcer (GU) or duodenal ulcer (DU), and to compare gastric motility between these two groups of patients. Studies were performed in 59 patients with recurrent active peptic-ulcer disease as diagnosed by gastrointestinal endoscopy: 31 patients had a GU and 28 patients had a DU. Gastric myoelectrical activity was evaluated by cutaneous electro-gastrography (EGG). The following EGG parameters were assessed: the percentage of normogastria (regular 2.4-3.6 cpm slow waves); the EGG power ratio; and the occurrence of a postprandial dip (PD), which is the transient decrease in EGG frequency after a meal. In the GU group, no significant change occurred in the percentage of normogastria or in the EGG power ratio observed after treatment with a proton-pump inhibitor. During the healed stage, the occurrence of PD remained unchanged. In contrast, in the DU group, the percentage of normogastria and the EGG power ratio were significantly increased after treatment. Moreover, during the healed stage, the occurrence of PD significantly increased compared with that during the active stage. These findings suggest that abnormal gastric myoelectrical activity plays an important role in the pathophysiology of recurrent GU rather than DU.
authors.affiliation: Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Science, Nagoya 467-8601, Japan. kamitake@med.nagoya-cu.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kamiya
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Naoko
authors.initials: N
authors.lastname: Misu
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirako
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Adachi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nagao
authors.forename: Michiko
authors.initials: M
authors.lastname: Shikano
authors.forename: Eriko
authors.initials: E
authors.lastname: Matsuhisa
authors.forename: Takashi
authors.initials: T
authors.lastname: Ando
authors.forename: Genjiro
authors.initials: G
authors.lastname: Kimura
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology*; D016145:Endoscopy, Digestive System; D005260:Female; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D064747:Lansoprazole; D008297:Male; D008875:Middle Aged; D016065:Myoelectric Complex, Migrating; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D054328:Proton Pump Inhibitors; D013270:Stomach / Q000503:physiopathology*; D013276:Stomach Ulcer / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology*; D014945:Wound Healing
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D064747:Lansoprazole; D009853:Omeprazole