Antidiabetic activity of Terminalia catappa Linn fruits.
In view of alleged antidiabetic potential, effect of the petroleum ether, methanol, and aqueous extracts of Terminalia catappa Linn (combretaceae) fruit, on fasting blood sugar levels and serum biochemical analysis in alloxan-induced diabetic rats were investigated. All the three extracts of Terminalia catappa produced a significant antidiabetic activity at dose levels 1/5 of their lethal doses. Concurrent histological studies of the pancreas of these animals showed comparable regeneration by methanolic and aqueous extracts which were earlier, necrosed by alloxan.
Nagappa
A N
AN
Pharmacy Group, Birla Institute of Technology and Sciences, Pilani-333031, Rajasthan, India. anantha@bits-pilani.ac.in
Thakurdesai
P A
PA
Venkat Rao
N
N
Singh
Jiwan
J
D000496:Alloxan / Q000009:adverse effects / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D005638:Fruit; D005905:Glyburide / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007194:India; D007515:Islets of Langerhans / Q000187:drug effects / Q000473:pathology; D051379:Mice; D010784:Photomicrography; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D029766:Terminalia; D013997:Time Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan; D005905:Glyburide