title: A model of desynchronizing deep brain stimulation with a demand-controlled coordinated reset of neural subpopulations.
abstract: The coordinated reset of neural subpopulations is introduced as an effectively desynchronizing stimulation technique. For this, short sequences of high-frequency pulse trains are administered at different sites in a coordinated way. Desynchronization is easily maintained by performing a coordinated reset with demand-controlled timing or by periodically administering resetting high-frequency pulse trains of demand-controlled length. Unlike previously developed methods, this novel approach is robust against variations of model parameters and does not require time-consuming calibration. The novel technique is suggested to be used for demand-controlled deep brain stimulation in patients suffering from Parkinson's disease or essential tremor. It might even be applicable to diseases with intermittently emerging synchronized neural oscillations like epilepsy.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Tass
mesh_terms: D003344:Cortical Synchronization; D004558:Electric Stimulation; D004599:Electric Stimulation Therapy; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000145:classification / Q000502:physiology*; D010507:Periodicity; D013997:Time Factors