title: Design of a molecular beacon PNA.
abstract: We have designed a novel dual-labeled PNA oligomer, having both a fluorescent dye and a quencher, by utilizing key compounds 1 and 2. We showed that the designed dual-labeled PNA oligomer works as a molecular beacon PNA. We also investigated the optimization of a stem-loop structure which can supersensitize the function as a molecular beacon PNA.
authors.affiliation: Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda Chiba 278-8510, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kitagawa
authors.forename: Youji
authors.initials: Y
authors.lastname: Ohori
authors.forename: Hisafumi
authors.initials: H
authors.lastname: Ikeda
authors.forename: Humihiro
authors.initials: H
authors.lastname: Fujimori
authors.forename: Yasuhumi
authors.initials: Y
authors.lastname: Murakami
authors.forename: Yushin
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D001704:Biopolymers; D015195:Drug Design; D005456:Fluorescent Dyes / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000737:chemistry*
chemical_list: D001704:Biopolymers; D005456:Fluorescent Dyes; D020135:Peptide Nucleic Acids