Enantioselective hydrogenation of tetrasubstituted olefins of cyclic beta-(acylamino)acrylates.
Hydrogenation of a series of cyclic beta-(acylamino)acrylates with tetrasubstituted olefins has been accomplished successfully with the use of Ru catalysts with chiral biaryl ligands such as C3-TunaPhos, and up to over 99% ee's have been achieved. This methodology provides an efficient catalytic method for the synthesis of both cis and trans chiral cyclic beta-amino acid derivatives.
Tang
Wenjun
W
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Wu
Shulin
S
Zhang
Xumu
X
D000179:Acrylates / Q000737:chemistry*; D000598:Amino Acids, Cyclic / Q000138:chemical synthesis*; D003516:Cycloparaffins / Q000737:chemistry*; D006865:Hydrogenation; D013237:Stereoisomerism
D000179:Acrylates; D000598:Amino Acids, Cyclic; D003516:Cycloparaffins