title: [Hypersensitivity to celecoxib].
abstract: Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) which acts via specific inhibition of cyclooxygenase-2 (synthesis of prostaglandins mediating pathological inflammation) but which preserves the homeostatic action of cyclooxygenase-1. The efficacy of celecoxib is similar to that of classical NSAIDs and its tolerance is comparable with that of placebo. We nevertheless observed one patient with hypersensitivity to celecoxib who developed fever, toxic skin reaction, and liver involvement.
authors.affiliation: Service de Médecine Interne, Centre Hospitalier Général, Boulevard Renaud, BP 159, 85407 Luçon Cedex.
authors.forename: Gérard
authors.initials: G
authors.lastname: Fradet
authors.forename: Anne
authors.initials: A
authors.lastname: Robin-Le Nechet
authors.forename: Hélène
authors.initials: H
authors.lastname: Huguenin
authors.forename: Anne
authors.initials: A
authors.lastname: Chiffoleau
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D000068579:Celecoxib; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D017116:Low Back Pain / Q000188:drug therapy; D011720:Pyrazoles; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib