title: Evaluation of antipyretic potential of Vernonia cinerea extract in rats.
abstract: The methanol extract of the whole plant of Vernonia cinerea (MEVC) was evaluated for its antipyretic potential on normal body temperature and yeast-induced pyrexia in rats. MEVC significantly reduced the normal body temperature at doses of 250 and 500 mg/kg body weight p.o. MEVC also lowered the elevated body temperature in the case of yeast-induced pyrexia in a dose dependent manner. The antipyretic effect of the extract at a dose of 500 mg/kg was identical to that of the standard drug paracetamol.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700032, India.
authors.forename: Malaya
authors.initials: M
authors.lastname: Gupta
authors.forename: U K
authors.initials: UK
authors.lastname: Mazumder
authors.forename: L
authors.initials: L
authors.lastname: Manikandan
authors.forename: S
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: P K
authors.initials: PK
authors.lastname: Haldar
authors.forename: S
authors.initials: S
authors.lastname: Roy
mesh_terms: D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005334:Fever / Q000517:prevention & control*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018514:Plant Structures; D051381:Rats; D035741:Vernonia; D015003:Yeasts
chemical_list: D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts