title: Effect of L-fucose and fucose-rich oligo- and polysaccharides (FROP-s) on skin aging: penetration, skin tissue production and fibrillogenesis.
abstract: Skin thickness is decreasing with age. This loss concerns both dermis and epidermis, cells and extracellular matrix. We could show here that percutaneous application of an L-fucose-containing preparation produced an increase of skin thickness and a densification of collagen bundles. We also could show that 3H-L-fucose penetrates in the dermis, a prerequisite for the above mentioned favorable pharmacological activities. These results, together with the previous favorable activities on the downregulation of matrix-degrading enzymes, free radical scavenging and increased cell proliferation confirm the favorable action of fucose and fucose-rich polysaccharides (FROP-s) on the skin by slowing down its aging.
authors.affiliation: Laboratoire universitaire de recherche en ophtalmologie, faculté de médecine Broussais-Hôtel Dieu, Universite Pierre-et-Marie-Curie (Paris 6), 1, place du Parvis Notre Dame, 75181 Paris cedex 4, France.
authors.forename: I
authors.initials: I
authors.lastname: Fodil-Bourahla
authors.forename: L
authors.initials: L
authors.lastname: Bizbiz
authors.forename: D
authors.initials: D
authors.lastname: Schoevaert
authors.forename: A M
authors.initials: AM
authors.lastname: Robert
authors.forename: L
authors.initials: L
authors.lastname: Robert
mesh_terms: D000287:Administration, Topical; D000818:Animals; D005260:Female; D024022:Fibrillar Collagens / Q000187:drug effects*; D005643:Fucose / Q000493:pharmacokinetics / Q000494:pharmacology*; D009844:Oligosaccharides / Q000493:pharmacokinetics / Q000494:pharmacology; D011134:Polysaccharides / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012869:Skin Absorption; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D024022:Fibrillar Collagens; D009844:Oligosaccharides; D011134:Polysaccharides; D005643:Fucose