Platelet-associated antibodies mediate protective autoimmune response in schizophrenia.
The peripheral blood platelets of schizophrenic patients were isolated, and the level of the platelet-associated antibodies (SPAA) was correlated with the rating scores of discrete schizophrenic symptom clusters evaluated with the Brief Psychiatric Rating Scale. Irrespective of medication and gender, symptom-dependent correlations were established between the SPAA levels and the relevant psychometric scores. The results indicate a heterogeneous origin of schizophrenia and imply the involvement of an autoimmune arm as a predominantly protective immune response.
Sinyakov
Michael S
MS
Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel. sinyakov@mail.biu.ac.il
Kessler
Bezalel
B
Karp
Leon
L
Weizman
Abraham
A
Kessler
Abraham R
AR
D000328:Adult; D000906:Antibodies / Q000097:blood* / Q000378:metabolism; D016824:Antigens, Human Platelet / Q000097:blood / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology*; D016000:Cluster Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012559:Schizophrenia / Q000097:blood / Q000276:immunology*; D013053:Spectrophotometry / Q000379:methods
D000906:Antibodies; D016824:Antigens, Human Platelet