Histological examination of the extrabulbar segment of the optic nerve in experimental animals after administration of Cladribine.
The experiment was carried out on rabbits, females of New Zealand breed, weighting about 3 kg. Rabbits from the experimental group I received Cladribine in the dose corresponding to the schema of the experimental treatment in the hairy cell leukemia and animals from the experimental group II, the dose corresponding to the experimental treatment in multiple sclerosis. The optic nerves were collected for histological examinations in the light microscope. It appeared that administration of Cladribine in the dose corresponding to the therapeutic dose used in therapy of hairy cell leukemia and sclerosis multiplex does not cause evident morphological changes in the extrabulbar segment of the optic nerve on the level of the light microscope.
Kwietniewska
Małgorzata
M
Department of Histology and Embryology with Lab of Experimental Cytology, Department of Neurology, Medical University of Lublin.
Stelmasiak
Zbigniew
Z
Sekita-Krzak
Joanna
J
Visconti
Józef
J
Czerny
Krystyna
K
D000818:Animals; D017338:Cladribine / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D007943:Leukemia, Hairy Cell / Q000188:drug therapy; D009103:Multiple Sclerosis / Q000188:drug therapy; D009900:Optic Nerve / Q000187:drug effects / Q000473:pathology; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000473:pathology*; D011817:Rabbits
D017338:Cladribine