[Ciclosporine A-induced gingival hyperplasia].
The increasing use of cyclosporine A (CSA) in organ transplants and in the treatment of autoimmune diseases has increased the incidence of cyclosporine A-related adverse effects, including gingival hyperplasia (GH). GH causes esthetic, speech, mastication and tooth growth problems in the affected patients. The prevalence of cyclosporine-induced GH varies in different studies and may be as high as 85%, depending on the diagnostic criteria. This review approaches etiological, histological and clinical issues, as well as the prevention and treatment of this important injury.
Ramalho
Vera Lúcia Costa
VL
Faculdade de Medicina de São José do Rio Preto, Brasil.
Ramalho
Horácio José
HJ
Cipullo
José Paulo
JP
Burdmann
Emmanuel A
EA
D016572:Cyclosporine / Q000009:adverse effects*; D005885:Gingival Hyperplasia / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016377:Organ Transplantation
D007166:Immunosuppressive Agents; D016572:Cyclosporine