title: [Functional analysis of the single nucleotide polymorphisms in the PRKCZ gene].
abstract: OBJECTIVE
  To study the function of 5 single nucleotide polymorphisms (SNPs) of the PRKCZ gene, a susceptibility gene for type 2 diabetes in Han population of North China, in the pathogenesis of the disease.
  
  
  METHODS
  Bioinformatic methods and reporter gene activity determination were used to analyze the function of the 5 SNPs.
  
  
  RESULTS
  The reporter gene activities of different alleles of 2 SNPs, rs427811 and rs809912, were obviously different, which implies that these 2 SNPs might be susceptibility loci of the disease.
  
  
  CONCLUSIONS
  The PRKCZ gene is further confirmed to be a susceptibility gene for type 2 diabetes in Han population of North China. Two SNPs in the gene play a role in the pathogenesis of the disease by affecting the expression level of PRKCZ gene.
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS, PUMC, Beijing 100005, China.
authors.forename: Hong-xia
authors.initials: HX
authors.lastname: Sun
authors.forename: Wei-nan
authors.initials: WN
authors.lastname: Du
authors.forename: Yun-feng
authors.initials: YF
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Zuo
authors.forename: Guo-dong
authors.initials: GD
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.forename: Bo-qin
authors.initials: BQ
authors.lastname: Qiang
authors.forename: Zhi-jian
authors.initials: ZJ
authors.lastname: Yao
authors.forename: Jian-mei
authors.initials: JM
authors.lastname: Hang
authors.forename: Hui-yuan
authors.initials: HY
authors.lastname: Luo
authors.forename: Heng
authors.initials: H
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Zhu
authors.initials: Z
authors.lastname: Chen
authors.forename: Fu-de
authors.initials: FD
authors.lastname: Fang
mesh_terms: D000483:Alleles; D044466:Asian People; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005006:Ethnicity; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011493:Protein Kinase C / Q000235:genetics*; D051745:Protein Kinase C-delta
chemical_list: C497258:PRKCD protein, human; D011493:Protein Kinase C; D051745:Protein Kinase C-delta