Synthesis and properties of N-t-butylaminoxyl nucleosides.
Novel purine nucleosides with a N-tert-butylhydroxylamino group at the 2-position of purine nucleus (1-3) were synthesized, which might prefer anti conformation and would not perturb DNA structure when incorporated into oligonucleotide. Oxidation of 1-3 by treatment with Ag2O or air afforded stable aminoxyl radicals (1'-3') and their properties were studied by EPR spectroscopy. 5-N-tert-butylhydroxylamino uridine (4) was also synthesized.
Kaneko
Toshiyuki
T
Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Aso
Mariko
M
Nakamura
Morihide
M
Matsui
Yasuhiro
Y
Koga
Noboru
N
Suemune
Hiroshi
H
D004578:Electron Spin Resonance Spectroscopy; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013113:Spin Labels
D009705:Nucleosides; D013113:Spin Labels