title: Cisplatin may be a valid alternative approach in ovarian carcinoma with carboplatin hypersensitivity. Report of three cases.
abstract: Platinum-based therapy is considered the standard treatment for patients with advanced ovarian cancer. Carboplatin has a more favorable toxicity profile than cisplatin; however, hypersensitivity reactions to carboplatin have been reported occasionally. We reviewed 112 cases of ovarian cancer treated with carboplatin at our institute to identify the hypersensitivity reactions to this chemotherapeutic agent. Hypersensitivity reactions were documented in nine cases (8%). No deaths occurred, but the reactions were judged severe in three of the 112 patients (2.6%). In our own experience with patients showing idiosyncrasy to carboplatin we observed successful resolution after retreatment with cisplatin. Since patients who relapse after initial treatment with carboplatin often respond to it a second time, it is important to continue this treatment.
authors.affiliation: Division of Medical Ontology, Centro di Riferimento Oncologico, Aviano, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Libra
authors.forename: Roberto
authors.initials: R
authors.lastname: Sorio
authors.forename: Angela
authors.initials: A
authors.lastname: Buonadonna
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Berretta
authors.forename: Peter
authors.initials: P
authors.lastname: Stefanovski
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Toffoli
authors.forename: Giovanna
authors.initials: G
authors.lastname: Mazzaglia
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Cordani
authors.forename: Franca
authors.initials: F
authors.lastname: Stivala
authors.forename: Mauro
authors.initials: M
authors.lastname: Boiocchi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D016190:Carboplatin / Q000009:adverse effects* / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016879:Salvage Therapy; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin; D002945:Cisplatin