Four glycosides from the leaves of Abeliophyllum distichum with inhibitory effects on angiotensin converting enzyme.
The bioassay-guided fractionation of the n-BuOH extract of Abeliophyllum distichum afforded acteoside (1), isoacteoside (2), rutin (3), and hirsutrin (4). Compounds 1-3 moderately inhibited the angiotensin I converting enzyme activity in a dose-dependent manner. Compounds 1-3 showed the 50% inhibitory concentration values of 228 micro g/mL, 290 micro g/mL, and 278 micro g/mL, respectively.
Oh
Hyuncheol
H
Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Chonbuk, Republic of Korea.
Kang
Dae-Gill
DG
Kwon
Tae-Oh
TO
Jang
Kyu Kwan
KK
Chai
Kyu-Yun
KY
Yun
Young-Gab
YG
Chung
Hun-Taeg
HT
Lee
Ho-Sub
HS
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000494:pharmacology; D006027:Glycosides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D029592:Oleaceae; D007703:Peptidyl-Dipeptidase A / Q000187:drug effects*; D010636:Phenols / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D012431:Rutin / Q000494:pharmacology; D059808:Polyphenols
D000806:Angiotensin-Converting Enzyme Inhibitors; D005960:Glucosides; D006027:Glycosides; D007703:Peptidyl-Dipeptidase A; D010636:Phenols; D010936:Plant Extracts; D012431:Rutin; C058956:acteoside; D059808:Polyphenols; C064683:isoacteoside