title: [Toll-like receptor and innate immunity in phylogenesis].
abstract: In protection against microbes, an organism recognizes the pathogen associated molecular pattern (PAMP) on microbes by pattern recognition receptor (PRR). Toll-like receptor is called innate immunity. A family of cell membrane receptor was found in recent years that can mediate innate immune responses through the activation of a series of immune-related genes. In phylogenesis, it is highly conservative. However, its functions are getting more diversified with the complication of the immune functions of organisms.
authors.affiliation: Department of Clinical Medicine, PUMC, Beijing 100730, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Zhu
authors.forename: Wei
authors.initials: W
authors.lastname: He
mesh_terms: D000818:Animals; D006801:Humans; D007109:Immunity; D008562:Membrane Glycoproteins / Q000276:immunology*; D010802:Phylogeny; D011956:Receptors, Cell Surface / Q000276:immunology*; D051193:Toll-Like Receptors
chemical_list: D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors