Use of QSARs in international decision-making frameworks to predict health effects of chemical substances.
This article is a review of the use of quantitative (and qualitative) structure-activity relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute toxicity, mutagenicity, carcinogenicity, and other health effects. A number of SAR and QSAR applications, by regulatory agencies and authorities, are reviewed. These include the use of simple QSAR analyses, as well as the use of multivariate QSARs, and a number of different expert system approaches.
Cronin
Mark T D
MT
School of Pharmacy and Chemistry, Liverpool John Moores University, Liverpool, England. m.t.cronin@livjm.ac.uk
Jaworska
Joanna S
JS
Walker
John D
JD
Comber
Michael H I
MH
Watts
Christopher D
CD
Worth
Andrew P
AP
D000818:Animals; D003659:Decision Making, Organizational; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D004785:Environmental Pollutants / Q000009:adverse effects*; D005062:European Union; D005103:Expert Systems; D033161:Government Regulation; D015386:Hazardous Substances / Q000009:adverse effects*; D007391:International Cooperation; D021281:Quantitative Structure-Activity Relationship; D018675:Toxicity Tests; D014481:United States
D004785:Environmental Pollutants; D015386:Hazardous Substances