Differential increase in natriuretic peptides in elite dynamic and static athletes.
The echocardiographic measures and plasma concentrations of either atrial natriuretic peptide (ANP) or brain natriuretic peptide (BNP) were compared in elite judo practitioners (static athletes), elite marathon runners (dynamic athletes) and healthy controls to investigate the relationship between the different types of left ventricular (LV) hypertrophy and plasma concentrations of natriuretic peptides in athletes. The LV mass and LV wall thickness of marathon runners and judo practitioners were significantly greater than those of controls. The LV end-diastolic dimension index was significantly larger in the marathon group, but smaller in the judo group. The left atrial dimension (LAD) index was significantly larger only in marathon runners. Plasma BNP concentrations were higher in both the judo and marathon groups than in controls, and positively correlated with LV mass as well as with deceleration time. Plasma ANP concentrations were significantly higher in marathon runners than in the controls and judo groups, and positively correlated with the LAD index, but negatively correlated with ejection fraction. Multivariate analyses showed that the type of athlete and LAD index were independent predictors of plasma BNP and ANP concentrations, respectively. Thus, there is an intimate link between plasma concentrations of natriuretic peptides and cardiac morphology in different types of athletes.
Date
Haruhiko
H
First Department of Internal Medicine, Miyazaki Medical College, Japan.
Imamura
Takuroh
T
Onitsuka
Hisamitsu
H
Maeno
Masakazu
M
Watanabe
Reiko
R
Nishihira
Kensaku
K
Matsuo
Takeshi
T
Eto
Tanenao
T
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D004452:Echocardiography; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D016139:Martial Arts; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009994:Osmolar Concentration; D012420:Running; D013318:Stroke Volume
D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor