Polypropionate lactones of deoxysugars glycosides from slime mold Lycogala epidendrum.
Two novel polypropionate lactone glycosides (1 and 2, i.e. lycogalinosides A and B) were isolated from the slime mold Lycogala epidendrum. Their structures, including the absolute configurations of the hydroxyl and methyls groups, were determined by means of extensive spectroscopic data such as mass, IR, UV, and 1D and 2D NMR spectra and chemical degradation followed by spectroscopic and chromatographic analysis. Compounds 1 and 2 are unique in structure containing a 2-deoxy-alpha-L-fucopyranosyl-(1-4)-6-deoxy-beta-D-gulopyranosyl unit and a beta-D-olivopyranosyl-(1-4)-beta-D-fucopyranosyl unit, respectively, and showed growth inhibitory activities against Gram-positive bacteria.
Rezanka
Tomás
T
Institute of Microbiology, Vídenská 1083, 14220 Prague, Czech Republic. rezanka@biomed.cas.cz
Dvoráková
Radmila
R
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002849:Chromatography, Gas / Q000379:methods; D004926:Escherichia coli / Q000187:drug effects; D005643:Fucose / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010804:Physarum / Q000737:chemistry*; D011422:Propionates / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism
D000890:Anti-Infective Agents; D006027:Glycosides; D007783:Lactones; D011422:Propionates; D005643:Fucose