title: Taurine prevents hypercholesterolemia in ovariectomized rats fed corn oil but not in those fed coconut oil.
abstract: We studied whether the type of dietary fatty acid influences the preventive effect of taurine on the ovarian hormone deficiency-induced increase in plasma cholesterol concentration in 6-mo-old ovariectomized rats. Rats were fed one of the following four diets for 28 d: purified diets based on corn oil, which is rich in linoleic acid, with or with out taurine (50 g/kg) or purified diets based on coconut oil, which is rich in lauric and myristic acids, with or without taurine. Body mass gain, food intake, liver weight and plasma apolipoprotein (apo) A-I, apo B, LDL and VLDL concentrations were not affected by the diets. On the other hand, taurine lowered the plasma total cholesterol concentration (P < 0.02) in rats fed corn oil, but not in those fed coconut oil. In rats fed both types of oils, taurine increased the LDL receptor mRNA level (P < 0.01), hepatic cholesterol 7alpha-hydroxylase activity (P < 0.01) and fecal bile acid excretion (P < 0.01). Taurine increased the HMG-CoA reductase mRNA level (P < 0.02) in the liver of rats fed coconut oil, but not in those fed corn oil. Taurine increased liver total lipid (P < 0.05) and triglyceride (P < 0.05) concentrations in rats fed corn oil, but not in those fed coconut oil. These results indicate that the effect of taurine on ovarian hormone deficiency-induced changes in cholesterol metabolism is influenced by the type of dietary fatty acids.
authors.affiliation: Department of Biological Resources, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Kishida
authors.forename: Shouko
authors.initials: S
authors.lastname: Miyazato
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogawa
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ebihara
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D000074263:Coconut Oil; D003314:Corn Oil / Q000494:pharmacology*; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D005243:Feces / Q000737:chemistry; D005260:Female; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics; D006937:Hypercholesterolemia / Q000517:prevention & control*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D010052:Ovariectomy; D010938:Plant Oils / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011973:Receptors, LDL / Q000235:genetics; D013654:Taurine / Q000494:pharmacology*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D004042:Dietary Fats, Unsaturated; D010938:Plant Oils; D012333:RNA, Messenger; D011973:Receptors, LDL; D014280:Triglycerides; D013654:Taurine; D003314:Corn Oil; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D002790:Cholesterol 7-alpha-Hydroxylase; D000074263:Coconut Oil