title: Ketamine-induced rotational asymmetry in evaluation of motor disturbances in rats with middle cerebral artery occlusion.
abstract: Intraperitoneal injection of ketamine in subanesthetic doses to Wistar rats with unilateral occlusion of the middle cerebral artery caused ipsilateral rotation (2-10 rpm), which was recorded in an automatic rotameter. The optimal dose of ketamine was 50 mg/kg. The animals were examined in an automatic rotameter for 40 min. Motor asymmetry persisted for no less than 2 months after surgery. According to the neurological test (Menzies scale) motor asymmetry in animals with focal brain ischemia persisted for no more than 30 days. The degree of ketamine-induced motor asymmetry in intact rats was 0.10 0.03 rpm.
authors.affiliation: V. P. Serbskii State Research Center for Social and Forensic Psychiatry, Moscow.
authors.forename: S V
authors.initials: SV
authors.lastname: Lebedev
authors.forename: S V
authors.initials: SV
authors.lastname: Petrov
authors.forename: D V
authors.initials: DV
authors.lastname: Blinov
authors.forename: I P
authors.initials: IP
authors.lastname: Lazarenko
authors.forename: V P
authors.initials: VP
authors.lastname: Chekhonin
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D003943:Diagnostic Techniques, Neurological; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D020244:Infarction, Middle Cerebral Artery; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D045442:Rotarod Performance Test
chemical_list: D018691:Excitatory Amino Acid Antagonists; D007649:Ketamine