[Generation of antibodies to Yersinia pseudotuberculosis antigens using the colloid gold particles as an adjuvant].
Serum titer achieved while producing antibodies to Y. pseudotuberculosis surface antigens with the use of colloid gold as adjuvant was as high as that achieved with the use of Freund's complete adjuvant (1:10,240). Still the amount of the antigen introduced when colloid gold particles were used as adjuvant was lower by 2 orders. The study revealed that colloid gold used as antigen carrier activated the phagocytic activity of lymphoid cells.
Staroverov
S A
SA
Institute of Biochemistry and Physiology of Plants and Microorganisms (Rus. Acad. Sci.), Vavilov State Agrarian University, Closed Joint-Stock Company Nita-Pharm, Saratov, Russia.
Ermilov
D N
DN
Shcherbakov
A A
AA
Semenov
S V
SV
Shchegolev
S Iu
SIu
Dykman
L A
LA
D000276:Adjuvants, Immunologic; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology; D017979:Gold Colloid / Q000276:immunology; D007114:Immunization / Q000379:methods; D011817:Rabbits; D015011:Yersinia pseudotuberculosis / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D017979:Gold Colloid