Nervous system involvement by pancreatic cancer.
From 1,229 consecutive patients with pancreatic cancer, seven patients who developed nervous system metastasis were evaluated retrospectively. Nervous system metastasis frequently antedated the diagnosis of the primary cancer (five out of seven patients). Four patients had cerebral metastasis. Brain computed tomography or magnetic resonance imaging revealed single or multiple cyst-like lesions with ring enhancement in half of these patients. Three patients had spinal metastasis which caused myelopathy in two. The metastatic lesions were localized to the thoracic level. Radiation therapy directed to the metastatic sites could not change the clinical course.
Park
Kyung-Seok
KS
Department of Neurology, Inje University Seoul Paik Hospital, Seoul, South Korea.
Kim
Manho
M
Park
Seong-Ho
SH
Lee
Kwang-Woo
KW
D000328:Adult; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D011829:Radiation Dosage; D012189:Retrospective Studies; D013120:Spinal Cord Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure