title: Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori.
abstract: To search for cancer chemopreventive agents from natural resources, many phytochemicals and food additives have been screened. Consequently, two natural sweeteners, mogroside V and 11-oxo-mogroside V isolated from the fruits of Momordica grosvenori, exhibited strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen (EBV-EA) by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). These sweet glycosides, having cucurbitane triterpenoid aglycon, exhibited the significant inhibitory effects on the two-stage carcinogenesis test of mouse skin tumors induced by peroxynitrite (ONOO-) as an initiator and TPA as a promoter. Further, 11-oxo-mogroside V also exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumor induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter.
authors.affiliation: Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. midori@mb.kyoto-phu.ac.jp
authors.forename: Midori
authors.initials: M
authors.lastname: Takasaki
authors.forename: Takao
authors.initials: T
authors.lastname: Konoshima
authors.forename: Yuji
authors.initials: Y
authors.lastname: Murata
authors.forename: Masaki
authors.initials: M
authors.lastname: Sugiura
authors.forename: Hoyoku
authors.initials: H
authors.lastname: Nishino
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kasai
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamasaki
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D003043:Cocarcinogenesis; D005260:Female; D008214:Lymphocytes; D051379:Mice; D008813:Mice, Inbred ICR; D029775:Momordica / Q000737:chemistry*; D030421:Peroxynitrous Acid / Q000494:pharmacology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D013549:Sweetening Agents / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: C477379:11-oxo-mogroside V; D016588:Anticarcinogenic Agents; D013549:Sweetening Agents; D014315:Triterpenes; D030421:Peroxynitrous Acid; D015127:9,10-Dimethyl-1,2-benzanthracene; C041740:mogroside V; D013755:Tetradecanoylphorbol Acetate