Vaccination against measles: a neverending story.
Measles, a highly contagious viral disease, is a major childhood killer in developing countries, accounting for almost 1 million deaths every year globally. Measles virus normally does not cause a persistent infection, no animal reservoir for measles virus exists, no vector is involved in its spread, only one serotype exists, the virus is antigenically stable and vaccination with the currently used live attenuated vaccines proved to be highly effective in preventing disease. Therefore, theoretically measles should be considered eradicable. This article provides a review of past and current measles vaccination efforts and development and need of new generation experimental measles vaccines.
Stittelaar
Koert J
KJ
Institute of Virology, Erasmus MC, Rotterdam, The Netherlands. stittelaar@viro.fgg.eur.nl
de Swart
Rik L
RL
Osterhaus
Albert D M E
AD
D000818:Animals; D002648:Child; D006801:Humans; D008457:Measles / Q000517:prevention & control*; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology*; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology
D008458:Measles Vaccine; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated