Simvastatin.
Simvastatin, or (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-3,4,5,6-tetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate, C(25)H(38)O(5), is almost isostructural with lovastatin, and the general conformational features are closely related to those of other reported crystal structures of statins. The only hydrogen bond present facilitates the formation of infinite chains of molecules along the b axis.
Cejka
Jan
J
Department of Solid State Chemistry, Prague Institute of Chemical Technology, Technická 5, 166 28 Prague 6, Czech Republic.
Kratochvíl
Bohumil
B
Císarová
Ivana
I
Jegorov
Alexandr
A
D000924:Anticholesteremic Agents / Q000737:chemistry*; D008958:Models, Molecular; D019821:Simvastatin / Q000737:chemistry*
D000924:Anticholesteremic Agents; D019821:Simvastatin