Chemoprevention of nonmelanoma skin cancer: experience with a polyphenol from green tea.
Nonmelanoma skin cancer is extremely common and is increasing in incidence. It would be very useful to have forms of therapy that would prevent precancerous changes from going on to form cancer, or to reverse the precancerous changes. Epidemiologic evidence in humans, in vitro studies on human cells, and clinical experiments in animals have identified polyphenol compounds found in tea to be possibly useful in reducing the incidence of various cancers, including skin cancer. To examine the potential for a polyphenol from green tea, epigallocatechin gallate, to act as a chemopreventive agent for nonmelanoma skin cancer, a randomized, double-blind, placebo-controlled phase II clinical trial of topical epigallocatechin gallate in the prevention of nonmelanoma skin cancer was performed.
Linden
Kenneth G
KG
Department of Dermatology, University of California, Irvine, 101 The City Drive, Orange, CA 92868, USA.
Carpenter
Philip M
PM
McLaren
Christine E
CE
Barr
Ronald J
RJ
Hite
Pamela
P
Sun
Joannie D
JD
Li
Kou-Tung
KT
Viner
Jaye L
JL
Meyskens
Frank L
FL
D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002392:Catechin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D018890:Chemoprevention; D002986:Clinical Trials as Topic; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D010636:Phenols / Q000627:therapeutic use*; D059808:Polyphenols; D012878:Skin Neoplasms / Q000517:prevention & control*; D013662:Tea; D014466:Ultraviolet Rays
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate