[The frequency distribution of flavin-containing monooxygenase 3 mutant alleles in 28 populations from Yunnan].
OBJECTIVE
To study the frequency distribution of flavin-containing monooxygenase 3 (FMO3) mutant alleles in 28 populations originating from 24 ethnic minorities in Yunnan of China.


METHODS
FMO3 genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism.


RESULTS
The average frequencies of FMO3/Stop(148), FMO3/Lys(158) and FMO3/Gly(308) were 0.395(0.174-0.803), 0.208 (0.056-0.414), 0.046(0-0.217), respectively. The frequencies of FMO3/Gly(308) in Blang, Huayaodai, Shuidai, Zhuang, De'ang, Jingpo, Nu and Hui populations were null.


CONCLUSIONS
It was found that the frequencies of FMO3 mutant alleles varied not only in different ethnic groups, but also in different populations that stemmed from the same ethnic group.
Zeng
Wei-min
WM
Human Genetics Center, Yunnan University, Kunming, Yunnan, 650091 PR China.
Yang
Jie
J
Dong
Yong-li
YL
Shi
Hong
H
Gao
Lu
L
Yang
Zhi-li
ZL
Lu
Jin
J
Hao
Zhao-jing
ZJ
Xiao
Chun-jie
CJ
D000483:Alleles; D002681:China; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D009154:Mutation; D010105:Oxygenases / Q000235:genetics*
D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming)