Blue rubber bleb nevus syndrome: immunohistochemical study.
Blue rubber bleb nevus is a rare entity consisting of distinctive angiomas in the skin and gastrointestinal tract, leading to occult or profound gastrointestinal bleeding and chronic anemia. The efficacy has been documented of systemic treatment with corticoids, interferon, vincristine, and, more recently, subcutaneous octreotide in the presence of active lesion proliferation or disseminated intravascular coagulation. A case of blue rubber bleb nevus syndrome with oral hemangiomas in a 24-year-old woman is reported. The surgical specimens were subjected to immunohistochemical study, which showed all of the hemangiomas to be in an inactive phase.
Villalain
Lucas
L
Department of Maxillofacial Surgery, University of Oviedo, Asturias Central Hospital, Oviedo, Spain.
Junquera
Luis M
LM
Díaz
Manuel
M
González
Manuel
M
D000328:Adult; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006392:Hemangioma, Cavernous / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D009062:Mouth Neoplasms / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D018329:Nevus, Blue / Q000737:chemistry / Q000473:pathology*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D014062:Tongue Neoplasms / Q000737:chemistry / Q000473:pathology*
D019394:Ki-67 Antigen; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D005169:Factor VIII