[Acute alterations of neurotransmitters levels in striatum of young rat after pilocarpine-induced status epilepticus].
High doses of the muscarinic cholinergic agonist, pilocarpine, result in behavioural changes, seizures and status epilepticus in rats. The purpose of the present work is to invetigate the striatal neurotransmissors level in young rats after status epilepticus induced by pilocarpine. Wistar rats were treated with a single dose of pilocarpine (400mg/Kg; s.c.). Controls received saline. Young animals were closed observed for behavioural changes during 1 and 24h. In these periods, the animals that developed status epilepticus and didn't survive this acute phase of seizures had the brains removed and striatal neurotransmissors level determined by HPLC. The concentration of dopamine, serotonine, dihydroxyphenylacetic acid, 5-hydroxyindolacetic acid was reduced and an increase in 4-hydroxy-3-methoxy-phenylacetic acid was observed. These results suggest that cholinergic activation can interage with dopaminergic and serotonergic systems in acute phase of the convulsive process in immature striatum.
de Freitas
Rivelilson Mendes
RM
Universidade Federal do Ceará (UFC), Fortaleza, CE, Brasil.
de Sousa
Francisca Cléa Florenço
FC
Vasconcelos
Silvânia Maria Mendes
SM
Viana
Glauce Socorro Barros
GS
Fonteles
Marta Maria de França
MM
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D018721:Muscarinic Agonists; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010862:Pilocarpine; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000139:chemically induced / Q000378:metabolism*
D018721:Muscarinic Agonists; D018377:Neurotransmitter Agents; D010862:Pilocarpine; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine