Inhibitory effects of resveratrol derivatives from dipterocarpaceae plants on tyrosinase activity.
Stilbene derivatives, which are resveratrol (3,4',5-trihydroxy-trans-stilbene) oligomers ranging from monomer to tetramer, isolated from Dipterocarpaceae plants were tested for their inhibitory effects against murine tyrosinase activity. The structure-activity relationships obtained in this study suggest that the double bond in the stilbene skeleton is critical for the inhibition, and also that molecular size is important for inhibitory potency.
Ohguchi
Kenji
K
Gifu International Institute of Biotechnology, Kakamigahara, Japan. kohguchi@giib.or.jp
Tanaka
Toshiyuki
T
Ito
Tetsuro
T
Iinuma
Munekazu
M
Matsumoto
Kenji
K
Akao
Yukihiro
Y
Nozawa
Yoshinori
Y
D000818:Animals; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D020448:Ericales / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D011753:Pyrones; D013267:Stilbenes; C011890:kojic acid; D014442:Monophenol Monooxygenase; D000077185:Resveratrol