title: New insights into drug resistance in cancer.
abstract: New findings by Kavallaris et al. characterize mechanisms of resistance to epothilones and paclitaxel in cell lines. One significant discovery is a novel tubulin point mutation positioned outside the paclitaxel binding site, which confers a high degree of drug resistance.
authors.affiliation: Institute of Chemical Biology & Drug Discovery, Department of Chemistry, State University of New York, Stony Brook, Stony Brook, NY 11794, USA.
authors.forename: Iwao
authors.initials: I
authors.lastname: Ojima
authors.forename: Cristiano
authors.initials: C
authors.lastname: Ferlini
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D019008:Drug Resistance, Neoplasm; D008870:Microtubules / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents