Monitoring the effect of chemotherapy in a mixed glioma by C-11-methionine PET.
The effect of chemotherapy with procarbazine, CCNU, and vincristine in an anaplastic oligoastrocytoma was monitored by repeated positron emission tomography (PET) with C-11-methionine (C-11-MET). Chemotherapy caused a continuous decline of active tumor volume at a rate of approximately 2.4% per day, resulting in complete remission that persisted until the end of follow-up at 3 years. Thus, the authors conclude that C-11-MET PET may be useful for monitoring chemotherapy in gliomas and deserves further study.
Herholz
K
K
Neurologische Universitätsklinik, Max-Planck-Institut für Neurologische Forschung, Gleueler Str 50, 50931 Köln, Germany. karl.herholz@pet.mpin-koeln.mpg.de
Kracht
L W
LW
Heiss
W D
WD
D000328:Adult; D001254:Astrocytoma / Q000000981:diagnostic imaging* / Q000188:drug therapy; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000187:drug effects; D017024:Chemotherapy, Adjuvant; D016903:Drug Monitoring / Q000379:methods*; D005260:Female; D006801:Humans; D008715:Methionine; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed / Q000379:methods*; D016896:Treatment Outcome
D019275:Radiopharmaceuticals; C086242:carbon-11 methionine; D008715:Methionine