Antinociceptive and anti-inflammatory effects of Croton malambo bark aqueous extract.
Croton malambo (K.) bark aqueous extract, popularly known in Venezuela as "palomatias" or "torco" was tested for acute toxicity and for its anti-inflammatory and antinociceptive effects using tail flick and writhing syndrome tests models, respectively. Croton malambo aqueous extract (6.15 mg/kg i.p.) administered intraperitoneally had a significant antinociceptive and anti-inflammatory effects compared to acetylsalicylic acid (200mg/kg p.o.) and sodium diclofenac (5.64 mg/kg p.o.). Studies to determine correlation between chemical composition and pharmacological activity are underway.
Suárez
Alírica I
AI
Facultad de Farmacia, Universidad Central de Venezuela, Apartado 40109, Caracas, Venezuela. asuarez@strix.ciens.ucv.ve
Compagnone
Reinaldo S
RS
Salazar-Bookaman
Maria M
MM
Tillett
Stephen
S
Delle Monache
Franco
F
Di Giulio
Camilo
C
Bruges
Gustavo
G
D000418:Albumins / Q000009:adverse effects; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D016227:Benzoquinones / Q000009:adverse effects / Q000037:antagonists & inhibitors; D029802:Croton; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D009020:Morphine / Q000494:pharmacology / Q000627:therapeutic use; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000188:drug therapy*; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D023382:Toxicity Tests, Acute; D014687:Venezuela
D000418:Albumins; D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016227:Benzoquinones; D010936:Plant Extracts; C029322:phenylbenzoquinone; D009020:Morphine