Interstitial magnetic resonance lymphography: comparative animal study of gadofluorine 8 and gadolinium diethylenetriamine-pentaacetic acid.
OBJECTIVE
We evaluated the usefulness of gadofluorine 8 (G8) and gadolinium diethylenetriamine-pentaacetic acid (Gd-DTPA) for interstitial magnetic resonance lymphography (MRL).


METHODS
Phantom imaging studies were conducted with G8 and Gd-DTPA corresponding to 0.1-0.005 micromol Gd/mL, and signal intensity was measured. Popliteal lymph node (PLN) accumulation was investigated in rabbits. Imaging was performed before and after subcutaneous administration of G8 (50 micromol Gd/mL) and Gd-DTPA (50 micromol Gd/mL). Contrast enhancement ratio measurements of PLN were determined both prior to and following the administration.


RESULTS
Signal intensity of phantom for G8 are higher than those for Gd-DTPA from 0.1 to 0.002 micromol Gd/mL (P < 0.0001). Imaging after 5 minutes can clearly detect PLN accumulation on two contrast agents. Nevertheless, PLN accumulation of Gd-DTPA disappeared after about 30 minutes. A statistically significant difference between G8 and Gd-DTPA can be seen from 5 to 90 minutes in CER (P < 0.0001). PLN became clearly visible at 5 minutes after the injection of G8 and Gd-DTPA. Nevertheless, PLN accumulation of Gd-DTPA disappeared at 30 minutes. Otherwise, PLN accumulation of G8 continued up to 90 minutes.


CONCLUSIONS
These studies indicated that G8 was more suitable than Gd-DTPA as a contrast agent for interstitial MRL up to 90 minutes.
Shimada
Morio
M
1st Department of Radiology, Toho University School of Medicine, Omorinishi 5-21-16, Otaku, Tokyo 143-8540, Japan. mshimada@med.toho-u.ac.jp
Yoshikawa
Kohki
K
Suganuma
Tsunetoku
T
Kayanuma
Hideki
H
Inoue
Yusuke
Y
Ito
Kuniko
K
Senoo
Atsushi
A
Hayashi
Sanshin
S
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008220:Lymphography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009942:Organometallic Compounds; D019047:Phantoms, Imaging; D011817:Rabbits
D003287:Contrast Media; D009942:Organometallic Compounds; C401682:gadofluorine 8; D019786:Gadolinium DTPA