title: Olanzapine pharmacokinetics are similar in Chinese and Caucasian subjects.
abstract: OBJECTIVE
  To compare the pharmacokinetic profiles and dose proportionality of olanzapine in Chinese and Caucasian subjects.
  
  
  METHODS
  Randomized, three-period study with 12 Chinese and 12 Caucasian, healthy, male subjects administered 2.5, 5 and 10 mg olanzapine. Noncompartmental pharmacokinetic parameters were derived.
  
  
  RESULTS
  No statistically significant racial differences in the weight-normalized pharmacokinetic parameters were observed except for Vz/Fnorm, which was 17% lower at the 5- and 10-mg dose in the Chinese group (95% confidence interval 8.49, 10.1 and 8.05, 9.73, respectively), compared with the Caucasian group (9.53, 12.8 and 9.39, 12.0, respectively). Olanzapine's pharmacokinetics were linear and dose proportional in both racial groups.
  
  
  CONCLUSIONS
  The pharmacokinetics of olanzapine are similar in both Chinese and Caucasian racial groups.
authors.affiliation: Lilly-NUS Centre for Clinical Pharmacology, National University of Singapore, Singapore.
authors.forename: Korbtham
authors.initials: K
authors.lastname: Sathirakul
authors.forename: Clark
authors.initials: C
authors.lastname: Chan
authors.forename: Leyan
authors.initials: L
authors.lastname: Teng
authors.forename: Richard F
authors.initials: RF
authors.lastname: Bergstrom
authors.forename: Kwee Poo
authors.initials: KP
authors.lastname: Yeo
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Wise
mesh_terms: D000284:Administration, Oral; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D044466:Asian People; D001569:Benzodiazepines; D006801:Humans; D008297:Male; D000077152:Olanzapine; D010890:Pirenzepine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D044465:White People
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine