Participation of endogenous opioids in pathogenesis of early neuroendocrine manifestations of prenatal stress syndrome.
We studied sex dimorphism in the content of norepinephrine and activity of enzymes involved in testosterone metabolism in the preoptic hypothalamic area of 10-day-old rats. Prenatal stress eliminated sex-related differences in these indices. These disturbances were absent in rats subjected to prenatal stress under conditions of opioid receptor blockade with naltrexone. These data attests to the important role of opioids in the pathogenesis of prenatal stress syndrome.
Reznikov
A G
AG
V P Komissarenko Institute of Endocrinology and Metabolism, Ukrainian Academy of Medical Sciences, Kiev.
Nosenko
N D
ND
Tarasenko
L V
LV
D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D007031:Hypothalamus / Q000737:chemistry / Q000378:metabolism; D008297:Male; D009271:Naltrexone / Q000378:metabolism; D009292:Narcotic Antagonists / Q000378:metabolism; D009490:Neurosecretory Systems / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism*; D018847:Opioid Peptides / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D013315:Stress, Psychological; D013577:Syndrome; D013739:Testosterone / Q000378:metabolism*
D009292:Narcotic Antagonists; D018847:Opioid Peptides; D013739:Testosterone; D009271:Naltrexone; D004298:Dopamine; D009638:Norepinephrine