title: [Biomarkers for toxicity and metabolic abnormalities of the main severe poisonings. Clinical and toxicologic symptoms. Conservative determination].
abstract: The members of the joint group "Toxicology and Clinical Biology" of the French Society of Clinical Biology (SFBC), the French Society of Analytical Toxicology (SFTA), and the Society of Clinical Toxicology (STC), suggest guidelines to meet the requirements of clinical biologists who are not specialized in toxicology. Based on good laboratory practice they propose a number of guidelines. Three synthetic tables have been established. They are not only toxicity biomarkers and metabolic disorders associated with the main severe intoxications, but also clinical signs that are observed during these intoxications, finally biological sampling as a precautionary measure. The table also takes into account approximately fifty xenobiotics: main clinical signs emergency, identification or quantification of the suspected product, useful biological markers, therapeutic, quantitations necessary to take into consideration patient care, and poison antidotes, are described. Recommendations regarding medical and forensic techniques are also proposed by the group. It is also necessary to collect and store biological samples when the individual patients are in charge. These samples will be analyzed or not depending on the individual case history.
authors.affiliation: Laboratoire de pharmacocinétique et de toxicologie cliniques GH, Le Havre.
authors.forename: J-P
authors.initials: JP
authors.lastname: Goullé
authors.forename: M
authors.initials: M
authors.lastname: Lhermitte
authors.forename: M
authors.initials: M
authors.lastname: Bartholi
authors.forename: J-C
authors.initials: JC
authors.lastname: Boyer
authors.forename: B
authors.initials: B
authors.lastname: Capolaghi
authors.forename: C
authors.initials: C
authors.lastname: Charlier
authors.forename: V
authors.initials: V
authors.lastname: Danel
authors.forename: G
authors.initials: G
authors.lastname: Desch
authors.forename: A
authors.initials: A
authors.lastname: Feuillu
authors.forename: B
authors.initials: B
authors.lastname: Flouvat
authors.forename: D
authors.initials: D
authors.lastname: Mathieu
authors.forename: P
authors.initials: P
authors.lastname: Nisse
authors.forename: N
authors.initials: N
authors.lastname: Sadeg
authors.forename: A
authors.initials: A
authors.lastname: Szymanowicz
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D019963:Clinical Chemistry Tests / Q000379:methods; D006801:Humans; D008659:Metabolic Diseases / Q000175:diagnosis*; D011041:Poisoning / Q000175:diagnosis*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers