Endocannabinoids and the regulation of body fat: the smoke is clearing.
Endocannabinoids, endogenous ligands of cannabinoid receptor type 1 (CB1), have emerged as novel and important regulators of energy homeostasis. A report in this issue demonstrates reduced body weight, fat mass, and appetite in CB1-/- mice. Examination of the underlying mechanisms reveals a dual role for endocannabinoids as they affect both appetite and peripheral lipolysis.
Horvath
Tamas L
TL
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. tamas.horvath@yale.edu
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000502:physiology*; D000818:Animals; D001066:Appetite; D063385:Cannabinoid Receptor Modulators; D002186:Cannabinoids / Q000378:metabolism*; D063388:Endocannabinoids; D005231:Fatty Acids, Unsaturated / Q000502:physiology*; D006801:Humans; D008024:Ligands; D008066:Lipolysis; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009765:Obesity / Q000188:drug therapy; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000235:genetics / Q000378:metabolism
D063385:Cannabinoid Receptor Modulators; D002186:Cannabinoids; D063388:Endocannabinoids; D005231:Fatty Acids, Unsaturated; D008024:Ligands; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug