title: Parotid carcinoma after autologous bone marrow transplantation for relapsed nephroblastoma.
abstract: Abdominal irradiation, especially if associated with doxorubicin administration, increases the risk of a secondary malignant neoplasm (SMN) after treatment of nephroblastoma. Secondary malignant salivary tumors are rare and usually occur in patients with previous cranial irradiation. The authors describe the case of a parotid mucoepidermoid carcinoma arising 13 years after diagnosis of nephroblastoma. This patient showed no characteristics reported in the literature as statistically significant for the development of an SMN. The authors believe that long-term, regular clinical examination is necessary even in patients at low risk of developing an SMN.
authors.affiliation: Department of Pediatric Hematology/Oncology, G Gaslini Children's Hospital, Genoa, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Manzitti
authors.forename: Paola
authors.initials: P
authors.lastname: Mereu
authors.forename: Riccardo
authors.initials: R
authors.lastname: Haupt
authors.forename: Arturo
authors.initials: A
authors.lastname: Di Blasi
authors.forename: Franca Fossati
authors.initials: FF
authors.lastname: Bellani
authors.forename: Sandro
authors.initials: S
authors.lastname: Dallorso
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000209:etiology* / Q000473:pathology*; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D008297:Male; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000473:pathology; D010307:Parotid Neoplasms / Q000209:etiology* / Q000473:pathology*; D013997:Time Factors; D009396:Wilms Tumor / Q000188:drug therapy* / Q000532:radiotherapy*
chemical_list: D004317:Doxorubicin