Cutaneous sarcoidlike lesions in B-cell chronic lymphocytic leukemia.
The development of systemic sarcoidosis in patients with malignancies is a well-known phenomenon. However, cutaneous sarcoidlike lesions are a rare finding. We report 2 patients with B-cell chronic lymphocytic leukemia and hypogammaglobulinemia who presented isolated cutaneous sarcoidlike lesions 9 years after the diagnosis of the hematologic malignancy in one case and after the second course of chemotherapy regimen in the other case. The role of cytokines released from malignant cells and of the hypogammaglobulinemia facilitating an unidentified infectious agent is questionable.
Bachmeyer
Claude
C
Département de Médecine Interne, Centre Hospitalier Laënnec, Boulevard Laënnec, B.P. 72, F-60109 Creil Cedex, France.
Debs
Rima
R
Aractingi
Selim
S
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001707:Biopsy, Needle; D005148:Facial Dermatoses / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012507:Sarcoidosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones