Spatial control of exocytosis.
During many key biological processes, exocytosis is confined to distinct regions of the plasma membrane. Spatial control of exocytosis correlates with altered membrane skeleton dynamics and assembly of local membrane microdomains. These domains act as local stages for the assembly and the regulation of molecular complexes (targeting patches) that mediate vesicle-membrane fusion. Furthermore, local activation of signaling pathways reinforces formation of these patches and might effect global repositioning of the secretory pathway toward sites of localized exocytosis.
Spiliotis
Elias T
ET
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5435, USA.
Nelson
W James
WJ
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D021961:Cell Membrane Structures / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D008561:Membrane Fusion / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D022161:Transport Vesicles / Q000378:metabolism*
D002352:Carrier Proteins