Secretion of proinflammatory cytokines by villous chorion tissue in spontaneous abortion.
Secretion of proinflammatory cytokines IL-1 beta, TNF-alpha, IL-6, IFN-alpha, and IFN-gamma by the chorion tissue (8-12 weeks) was studied in normal gestation and spontaneous abortion. The production of IL-1 beta, TNF-alpha, and IFN-alpha virtually did not change in spontaneous abortion, while IFN-gamma was not secreted in all experimental groups. The production of IL-6 increased more than 2-fold in patients with spontaneous abortion during the first trimester. These data confirm the involvement of this cytokine in the reproductive processes and in the pathogenesis of miscarriage.
Pavlov
O V
OV
Laboratory of Immunology, D. O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg.
Sel'kov
S A
SA
Lalayan
D V
DV
Arzhanova
O N
ON
D000022:Abortion, Spontaneous / Q000276:immunology*; D002824:Chorionic Villi / Q000033:anatomy & histology / Q000378:metabolism*; D046508:Culture Techniques; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First
D016207:Cytokines