title: [Phase III additional clinical study of 111In-pentetreotide (MP-1727): diagnosis of gastrointestinal hormone producing tumors based on the presence of somatostatin receptors].
abstract: Additional phase III multicenter clinical study was performed to investigate the efficacy, safety, and usefulness of somatostatin receptor scintigraphy using 111In-pentetreotide (MP-1727), which binds to somatostatin receptors. Forty patients were included in the study; Group A: 18 patients, gastrointestinal hormone producing tumors had been detected with conventional imaging modalities, Group B: 22 patients, no tumors had been detected with conventional imaging modalities in spite of high serum hormone levels. By comparing the results of the octreotide suppression test, 12/16 cases (75.0%) of Group A and 11/19 cases (57.9%) of Group B were assessed as "effective." By comparing the results of immunohistological examination, 5/9 cases (55.6%) of Group A and 2/4 cases (50.0%) of Group B were assessed as "effective." Severe adverse events were not observed in any of the evaluable 35 cases. MP-1727 was judged as clinically useful in 11/16 cases (68.8%) of Group A and 5/19 cases (26.3%) of group B. These results suggest that MP-1727 scintigraphy is very useful for the diagnosis and decision of the therapeutic strategy of gastrointestinal hormone producing tumors.
authors.affiliation: Department of Nuclear Medicine, Kyoto University Faculty of Medicine.
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Saga
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Itoi
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Keigo
authors.initials: K
authors.lastname: Endo
authors.forename: Goro
authors.initials: G
authors.lastname: Watanabe
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Maruno
authors.forename: Rikuo
authors.initials: R
authors.lastname: Machinami
authors.forename: Kiyoshi
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authors.lastname: Koizumi
authors.forename: Taro
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authors.lastname: Ichikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takami
authors.forename: Miyuki
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authors.lastname: Ishibashi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kubo
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Kusakabe
authors.forename: Yukio
authors.initials: Y
authors.lastname: Hirata
authors.forename: Yuji
authors.initials: Y
authors.lastname: Murata
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Miyachi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsubuku
authors.forename: Harumi
authors.initials: H
authors.lastname: Sakahara
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Katada
authors.forename: Norihisa
authors.initials: N
authors.lastname: Tonami
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Junji
authors.initials: J
authors.lastname: Konishi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Imamura
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Doi
authors.forename: Akira
authors.initials: A
authors.lastname: Shimatsu
authors.forename: Shinzaburo
authors.initials: S
authors.lastname: Noguchi
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishikawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nakajo
mesh_terms: D000368:Aged; D005260:Female; D005768:Gastrointestinal Hormones / Q000096:biosynthesis*; D006801:Humans; D007205:Indium Radioisotopes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000378:metabolism; D017481:Receptors, Somatostatin / Q000378:metabolism*; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D005768:Gastrointestinal Hormones; D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; D013004:Somatostatin; C081788:pentetreotide