Cytokinesis: a logical GAP.
Two complexes localize to the central spindle and regulate completion of cytokinesis: one, centralspindlin, contains a kinesin-like protein and a Rho-family GAP; the second contains Aurora B kinase. Aurora B kinase is known to regulate localization of centralspindlin and may regulate the activity of the RhoGAP component of centralspindlin.
Mishima
Masanori
M
Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030, Vienna, Austria.
Glotzer
Michael
M
D000595:Amino Acid Sequence; D064127:Aurora Kinases; D002455:Cell Division / Q000502:physiology*; D020690:GTPase-Activating Proteins / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism / Q000502:physiology*; D008969:Molecular Sequence Data; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D008941:Spindle Apparatus / Q000502:physiology
D020690:GTPase-Activating Proteins; D008869:Microtubule-Associated Proteins; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases