Central non-NMDA receptors of a honey bee with hereditary kynurenine deficiency.
Pharmacological characteristics of non-NMDA receptors involved in associative learning were studied in wild honey bees (normal) and carriers of snow laranja mutation (kynurenine deficiency) by pharmacological analysis and behavioral criteria. The effects of systemic injections of non-NMDA receptor agonists (AMPA, kainic, quisqualic, and domoic acids), AMPA receptor antagonist (NS257-HCl), and AMPA receptor modulator (cyclothiaside) on retention of conditioned reflexes in short-term memory (1 min after the end of learning) were studied. The pharmacological characteristics of non-NMDA receptors were changed in snow laranja mutants with kynurenine deficiency.
Lopatina
N G
NG
Laboratory of Higher Nervous Activity Genetics, Russian Academy of Sciences, St. Petersburg.
Ryzhova
I V
IV
Chesnokova
E G
EG
Zachepilo
T G
TG
Voike
E
E
D000818:Animals; D000959:Antihypertensive Agents / Q000378:metabolism; D001516:Bees / Q000235:genetics* / Q000378:metabolism*; D001581:Benzothiadiazines / Q000378:metabolism; D003214:Conditioning, Classical; D018690:Excitatory Amino Acid Agonists / Q000378:metabolism; D018691:Excitatory Amino Acid Antagonists / Q000378:metabolism; D007737:Kynurenine / Q000172:deficiency*; D008568:Memory / Q000502:physiology; D017470:Receptors, Glutamate / Q000378:metabolism*
D000959:Antihypertensive Agents; D001581:Benzothiadiazines; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D017470:Receptors, Glutamate; D007737:Kynurenine; C004639:cyclothiazide