title: A case of giant expanding cephalhematoma: does the administration of blood coagulation factor XIII reverse symptoms?
abstract: BACKGROUND
  The mechanism of continuous massive hemorrhage into the subperiosteal space in children without coagulation defects is unknown. We report a case of giant expanding cephalhematoma reversed by the administration of blood coagulation factor XIII concentrate.
  
  
  METHODS
  The patient was an 8-year-old boy with a history of minor head trauma who developed a giant expanding cephalhematoma with intraorbital extension. The laboratory data showed severe anemia, but a routine blood coagulation test showed no abnormalities except for a low factor XIII level.
  
  
  RESULTS
  The administration of factor XIII concentrate completely reversed the symptoms in 2 weeks.
  
  
  CONCLUSIONS
  We speculate that one of the possible mechanisms of cephalhematoma expansion without blood coagulation defects might be acquired factor XIII deficiency from severe hemorrhage in a hematoma.
authors.affiliation: Department of Neurosurgery, Koshigaya Municipal Hospital, Saitama, Japan.
authors.forename: Chikashi
authors.initials: C
authors.lastname: Maruki
authors.forename: Madoka
authors.initials: M
authors.lastname: Nakajima
authors.forename: Akira
authors.initials: A
authors.lastname: Tsunoda
authors.forename: Michimasa
authors.initials: M
authors.lastname: Ebato
authors.forename: Furitsu
authors.initials: F
authors.lastname: Ikeya
mesh_terms: D001847:Bone Diseases / Q000150:complications / Q000188:drug therapy; D002648:Child; D004172:Diplopia / Q000209:etiology; D005176:Factor XIII / Q000008:administration & dosage / Q000627:therapeutic use*; D006261:Headache / Q000209:etiology; D006406:Hematoma / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D010521:Periosteum; D012886:Skull / Q000473:pathology*
chemical_list: D005176:Factor XIII