title: [Combination therapy with fluvastatin and fenofibrate in ischemic heart disease patients with combined hyperlipidemia and type 2 diabetes].
abstract: OBJECTIVE
  To assess efficacy of combination therapy with fluvastatin and fenofibrate in ischemic heart disease (IHD) patients with combined hyperlipidemia and type 2 diabetes.
  
  
  METHODS
  Patients with IHD and combined hyperlipidemia with (n=56)) or without type 2 diabetes (n=30).
  
  
  METHODS
  After 8-week diet period the patients were randomized to 4 weeks monotherapy with either fluvastatin (40 mg/day) or micronized fenofibrate (200 mg/day). In patients whose low-density lipoprotein cholesterol (LDL CH) remained > 2,6 mmol/1 and triglycerides (TG) > 2.3 mmol/1 combination of fluvastatin 40 mg/day and fenofibrate 200 mg/day was used for the next 12 weeks.
  
  
  RESULTS
  Target levels of LDL CH and TG were achieved in 75 and 88%, respectively, of diabetics, and in 73 and 88%, respectively, of non-diabetics.
  
  
  CONCLUSIONS
  The use of combination of fluvastatin and fenofibrate was more effective then monotherapy for correction of lipid abnormalities in combined hyperlipidemia both in diabetics and non-diabetics with IHD.
authors.forename: N E
authors.initials: NE
authors.lastname: Sarano
authors.forename: S G
authors.initials: SG
authors.lastname: Kozlov
authors.forename: M G
authors.initials: MG
authors.lastname: Tvorogova
authors.forename: A A
authors.initials: AA
authors.lastname: Liakishev
authors.forename: V G
authors.initials: VG
authors.lastname: Naumov
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004359:Drug Therapy, Combination; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D005260:Female; D011345:Fenofibrate / Q000008:administration & dosage*; D000077340:Fluvastatin; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D007211:Indoles / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D005229:Fatty Acids, Monounsaturated; D000960:Hypolipidemic Agents; D007211:Indoles; D000077340:Fluvastatin; D011345:Fenofibrate