Evaluation of anti-inflammatory potential of Pavetta indica Linn. leaf extract (family: Rubiaceae) in rats.
The anti-inflammatory potential of methanol extract of Pavetta indica Linn. leaves (Family: Rubiaceae) was evaluated against several models of inflammation such as carragenin, histamine and dextran induced pedal inflammation in rats. The extract showed 48.41%, 41.10% and 24.22% inhibition respectively; when compared to that of control animals. The effect was comparable with that of the standard drug indomethacin, a standard non-steroidal anti-inflammatory drug. Simultaneous subplantar administration of the extract and carrageenin in a mixture helps in differentiating true anti-inflammatory action from an apparent anti-inflammatory effect due to counter-irritant activity. The methanol extract also effectively and significantly reduced cotton pellet induced granuloma. The percentage of inhibition was 62.78 at the dose 500 mg/kg, thereby suggesting its activity in the proliferative phase of the inflammatory process.
Mandal
Subhash C
SC
Division of Pharmacognosy & Phytochemistry, Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadavpur University, Calcutta, India. subhashmandal@yahoo.com
Mohana Lakshmi
S
S
Ashok Kumar
C K
CK
Sur
Tapas K
TK
Boominathan
R
R
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D003911:Dextrans; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D015745:Granuloma, Foreign-Body / Q000517:prevention & control; D006632:Histamine; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D019666:Rubiaceae
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003911:Dextrans; D010936:Plant Extracts; D006632:Histamine; D002351:Carrageenan; D007213:Indomethacin