title: Exposure to animals and selected risk factors among Canadian farm residents with Hodgkin's disease, multiple myeloma, or soft tissue sarcoma.
abstract: Exposures to farm animals has been associated with certain rare cancers. Simultaneously, using the same methodology and control group, we conducted a six-province incident, population-based study of Hodgkin's disease (HD), multiple myeloma (MM), and soft tissue sarcoma (STS). Farm residence or work was reported by 38% (n = 119) of HD, 45% (n = 178) of MM, 43% (n = 156) of STS cases and 45% (n = 673) of controls. We conducted conditional logistic regression analyses and report odds ratios (OR(adj)) and 95% confidence intervals. After adjustment for covariates, exposure to farm animals had minimal effect on risk. The independent risk factors after adjustment for covariates were a family history of cancer (MM, STS), occupational uranium exposure (HD), professional driving (MM), and personal previous cancer (MM) or shingles (HD, MM).
authors.affiliation: Institute of Agricultural Rural and Environmental Health, Saskatchewan Cancer Agency, Saskatoon SK S7N 0W8, Canada.
authors.forename: Punam
authors.initials: P
authors.lastname: Pahwa
authors.forename: Helen H
authors.initials: HH
authors.lastname: McDuffie
authors.forename: James A
authors.initials: JA
authors.lastname: Dosman
authors.forename: Diane
authors.initials: D
authors.lastname: Robson
authors.forename: John R
authors.initials: JR
authors.lastname: McLaughlin
authors.forename: John J
authors.initials: JJ
authors.lastname: Spinelli
authors.forename: Shirley
authors.initials: S
authors.lastname: Fincham
mesh_terms: D000293:Adolescent; D000328:Adult; D000382:Agricultural Workers' Diseases / Q000139:chemically induced / Q000453:epidemiology*; D000822:Animal Husbandry; D000818:Animals; D000829:Animals, Domestic; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D003625:Data Collection; D006540:Herbicides / Q000506:poisoning; D006689:Hodgkin Disease / Q000139:chemically induced / Q000453:epidemiology*; D006801:Humans; D009101:Multiple Myeloma / Q000139:chemically induced / Q000453:epidemiology*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D010575:Pesticides / Q000506:poisoning; D012307:Risk Factors; D012509:Sarcoma / Q000139:chemically induced / Q000453:epidemiology*; D011795:Surveys and Questionnaires; D000078329:Workforce
chemical_list: D006540:Herbicides; D010575:Pesticides