Abnormal oesophageal motility in patients with chronic cough.
BACKGROUND
Although gastro-oesophageal reflux is a recognised cause of chronic cough, the role of oesophageal dysmotility is unknown. The aim of this study was to determine the prevalence of abnormal oesophageal motility in a selected group of patients with chronic cough.


METHODS
Oesophageal manometry and 24 hour pH monitoring were performed in 43 patients with chronic cough, 34 of whom had symptoms suggestive of gastro-oesophageal reflux. Comparative manometric measurements were made in 21 healthy subjects.


RESULTS
Nine patients with chronic cough had normal manometry and 24 hour pH. Of the remaining 34 patients, 11 (32%) had abnormal manometry alone, five (15%) had abnormal 24 hour pH monitoring alone, and in 18 (53%) both tests were abnormal. Only one patient in the control group had manometric abnormalities.


CONCLUSIONS
These results point to a previously unrecognised high prevalence of abnormal oesophageal manometry in patients presenting with chronic cough. Oesophageal dysmotility may therefore be important in the pathogenesis of cough in these patients.
Kastelik
J A
JA
Division of Academic Medicine, Postgraduate Medical Institute, University of Hull, Hull, UK.
Redington
A E
AE
Aziz
I
I
Buckton
G K
GK
Smith
C M
CM
Dakkak
M
M
Morice
A H
AH
D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D002908:Chronic Disease; D002940:Circadian Rhythm; D003371:Cough / Q000209:etiology* / Q000503:physiopathology; D015154:Esophageal Motility Disorders / Q000150:complications*; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011312:Pressure