Histological changes in the pancreas of white rats after administering cephalexin and ethanol.
The research was conducted on male Wistar rats weighing approximately 200 g. Animals of experimental group I were administered 20% ethyl alcohol for drinking, animals of experimental group II--cephalexin in the dose of 42 mg daily, animals of experimental group III--simultaneously alcohol and cephalexin in the mentioned doses. After 10 days the animals were guillotined and pancreas was taken for research. On paraffin sections 7 mu thick there were carried out H + E stain and PAS reaction aimed at discovering neutral mucopolysaccharides. After administering alcohol there was stated a decrease in the activity of exocrime cells and after administering of cephalexim--an increase in this activity. A simultaneous administration of ethyl alcohol and antibiotic causes trophic changes, which can be noticed as introductory, but at this stage--reversible, degenerative changes.
Zarebska
Alicja
A
Department and Institute of Histology and Embryology, Laboratory for Experimental Cytology, Medical University of Lublin.
Bakiera
Katarzyna
K
Visconti
Józef
J
Kwietniewska
Małgorzata
M
Czerny
Krystyna
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D002506:Cephalexin / Q000633:toxicity*; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004347:Drug Interactions; D000431:Ethanol / Q000633:toxicity*; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology; D010195:Pancreatitis / Q000139:chemically induced* / Q000473:pathology; D019512:Pancreatitis, Alcoholic / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
D000900:Anti-Bacterial Agents; D000431:Ethanol; D002506:Cephalexin