title: [Role of leptin in the pathogenesis of obesity-related hypertension].
abstract: OBJECTIVE
  To assess the role of leptin in the pathogenesis of obesity-related hypertension and the relationship between blood pressure (BP), and body mass index (BMI), insulin resistance and leptin were examined.
  
  
  METHODS
  560 non-diabetic men, aged 35 - 75, selected from volunteers of health screening test during 2 000 were divided into hypertension group (n = 321, BP >or= 140/90 mm Hg without antihypertensive medication). and normal blood pressure group (n = 239). The body weight, waist hip ratio,BP, plasma glucose, serum lipids, true insulin (TI) and leptin were measured after overnight fast. Insulin sensitivity was assessed by the HOMA insulin resistance index (HOMA-R).
  
  
  RESULTS
  Fasting leptin level showed good correlation with BMI, fasting TI, HOMA-R, BP and also triglycerides (all P < 0.01). After adjustment for age, BMI and HOMA-R, serum leptin was still positively correlated to SBP (r = 0.11, P < 0.05), and was significantly higher in hypertensive subjects than in normotensive subjects (geometric mean 6.4 vs 4.7 micro g/L, P < 0.001). Logistic regression analysis demonstrated that leptin remained significantly associated with hypertension after adjustment for potentially confounding factors.
  
  
  CONCLUSIONS
  Leptin may play an important role in the pathogenesis of obesity related hypertension.
authors.affiliation: Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Cong-yuan
authors.initials: CY
authors.lastname: Wu
authors.forename: Zhi-wei
authors.initials: ZW
authors.lastname: Zhan
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Kui
authors.initials: K
authors.lastname: Zhang
authors.forename: Xiao-guang
authors.initials: XG
authors.lastname: Li
authors.forename: Li-hong
authors.initials: LH
authors.lastname: Gan
authors.forename: Bao-hua
authors.initials: BH
authors.lastname: Ji
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology*; D020738:Leptin / Q000097:blood*; D016015:Logistic Models; D008875:Middle Aged; D009765:Obesity / Q000150:complications*
chemical_list: D020738:Leptin