title: Modeling stability of photoheterotrophic continuous cultures in photobioreactors.
abstract: Continuous cultures of the purple non-sulfur bacterium Rhodospirillum rubrum were grown in a cylindrical photobioreactor in photoheterotrophic conditions, using acetate as carbon source. A new kinetic and stoichiometric knowledge model was developed, and its ability to simulate experimental results obtained under varying incident light fluxes and residence times is discussed. The model accurately predicts the stable, unstable, or oscillating behavior observed for the reactor productivity. In particular, the values of residence time corresponding to a subcritical bifurcation with a typical hysteresis effect are calculated and analyzed. The robustness of the proposed model allows the engineering operating domain of the photobioreactor function to be set and offers a promising tool for the design and control of such photoheterotrophic processes.
authors.affiliation: Laboratoire de Génie Chimique et Biochimique, Université Blaise Pascal-CUST 24, avenue des Landais, BP 206, F 63174 AUBIERE Cedex, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Cornet
authors.forename: Lidia
authors.initials: L
authors.lastname: Favier
authors.forename: Claude-Gilles
authors.initials: CG
authors.lastname: Dussap
mesh_terms: D000085:Acetates / Q000378:metabolism*; D019149:Bioreactors / Q000382:microbiology*; D018929:Cell Culture Techniques / Q000379:methods*; D002455:Cell Division / Q000502:physiology / Q000528:radiation effects; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D006706:Homeostasis / Q000502:physiology*; D008027:Light; D008954:Models, Biological; D017711:Nonlinear Dynamics; D018462:Photobiology / Q000379:methods*; D015203:Reproducibility of Results; D012244:Rhodospirillaceae / Q000166:cytology / Q000254:growth & development / Q000378:metabolism* / Q000528:radiation effects*; D012680:Sensitivity and Specificity
chemical_list: D000085:Acetates