Acute bullous purpura associated with hyperhomocysteinemia and antiphospholipid antibodies.
We describe a female patient with an acute purpuric and bullous eruption mainly affecting the lower aspect of the legs. Skin biopsy specimens demonstrated microvascular occlusions with fibrin thrombi but no dermal inflammation. Intermediate hyperhomocysteinemia and transient antiphospholipid antibodies were evidenced as factors of thrombophilia. The responsibility of the latter in the onset of the cutaneous lesions is discussed.
Martin
Ludovic
L
Service de Dermatologie, Hôpital Porte-Madeleine, BP 2439, CHR d'Orléans, 45032 Orléans Cedex, France. Ludovic.martin@chr.orleans.fr
Armingaud
Pierre
P
Georgescu
Voichita
V
Matre
Frédéric
F
Legac
Eric
E
Estève
Eric
E
D000208:Acute Disease; D000368:Aged; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011241:Prednisone / Q000008:administration & dosage; D011379:Prognosis; D011693:Purpura / Q000276:immunology / Q000473:pathology; D018570:Risk Assessment; D012720:Severity of Illness Index; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D019851:Thrombophilia / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D016896:Treatment Outcome
D017152:Antibodies, Antiphospholipid; D011241:Prednisone