title: A case report of multicentric verrucous carcinoma of the female genital tract.
abstract: BACKGROUND
  Verrucous carcinoma is a variant of squamous cell carcinoma with distinct features including slow locally invasive growth and verrucous appearance. Verrucous carcinoma of the vagina is considered an extremely rare lesion because only 17 cases have been reported in the literature.
  
  
  METHODS
  We report a case of vaginal verrucous carcinoma with a second focus in the cervix. The patient was treated with surgery and adjuvant interferon therapy for local recurrence. Human papillomavirus was detected in both vaginal and cervical tumor tissue by immunohistochemistry.
  
  
  CONCLUSIONS
  Diagnosis of verrucous carcinoma may be difficult, particularly if biopsy specimen involves only the surface epithelium. The role of human papillomavirus as an etiologic agent in verrucous carcinoma is still a matter of discussion. Effective management requires surgical resection. The efficiencies of radiotherapy and interferon therapy are discussed.
authors.affiliation: Ankara Numune Research and Training Hospital, Clinic of Obstetrics, Ankara, Turkey. aycagyorganci@hotmail.com
authors.forename: Aycag
authors.initials: A
authors.lastname: Yorganci
authors.forename: Ebru
authors.initials: E
authors.lastname: Serinsoz
authors.forename: Arzu
authors.initials: A
authors.lastname: Ensari
authors.forename: Ayse
authors.initials: A
authors.lastname: Sertcelik
authors.forename: Firat
authors.initials: F
authors.lastname: Ortac
mesh_terms: D000368:Aged; D018289:Carcinoma, Verrucous / Q000473:pathology*; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000473:pathology*