title: [Mycobacterium haemophilum as the cause of lymphadenitis in the neck in an otherwise healthy boy].
abstract: In an 8.5-year-old boy with severe recurring unilateral swelling of the neck, infection with Mycobacterium haemophilum was established. In addition to the more usual causative agents, cervical lymphadenopathy in children can, in rare cases, be caused by M. haemophilum. The skin tests did not differentiate between Mycobacterium avium and Mycobacterium tuberculosis infection. There was no evidence of specific immune deficiencies. The swelling did not respond to treatment with four tuberculostatic drugs (rifampicin, isoniazid, pyrazinamide and ethambutole), nor to repeated surgical excision. Finally, M. haemophilum grew on the culture despite sub-optimal culture conditions. Thereupon the patient was treated with co-trimoxazole and recovered in two weeks. This is the first patient with cervical lymphadenopathy caused by M. haemophilum to be described in the Netherlands. M. haemophilum grows on an iron-rich medium at a relatively low temperature (30-32 degrees C). In cases of cervical lymphadenopathy, it is advisable to consider M. haemophilum as a cause and to adjust the culture conditions accordingly.
authors.affiliation: Onze Lieve Vrouwe Gasthuis, afd. Kindergeneeskunde, Amsterdam. ej.griendt@vumc.nl
authors.forename: E J
authors.initials: EJ
authors.lastname: van de Griendt
authors.forename: P J
authors.initials: PJ
authors.lastname: Rietra
authors.forename: R N
authors.initials: RN
authors.lastname: van Andel
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D008199:Lymphadenitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D009164:Mycobacterium Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D018393:Mycobacterium haemophilum / Q000254:growth & development / Q000302:isolation & purification*; D009333:Neck
chemical_list: D000995:Antitubercular Agents