Effect of antioxidants on glucose metabolism and plasma lipids in HIV-infected subjects with lipoatrophy.
Ten HIV-infected nucleoside reverse transcriptase inhibitor-treated subjects with lipoatrophy or sustained hyperlactatemia were given antioxidants: vitamins C, E, and N-acetyl cysteine. After 24 weeks, anthropometrics did not change significantly, except for a modest decrease in the waist-to-hip ratio. Fasting low-density lipoprotein cholesterol trended toward lower values. Fasting glucose significantly increased along with a significant increase in homeostatic model assessment values, reflecting an increase in insulin resistance. Controlled trials are required to evaluate directly the effects of these agents on lipid and glucose metabolism.
McComsey
Grace
G
Rainbow Babies and Children's Hospital, Cleveland, Ohio 44106, USA. mccomsey.grace@clevelandactu.org
Southwell
Heather
H
Gripshover
Barbara
B
Salata
Robert
R
Valdez
Hernan
H
D000111:Acetylcysteine / Q000627:therapeutic use; D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D001823:Body Composition; D002784:Cholesterol / Q000097:blood; D005260:Female; D005947:Glucose / Q000032:analysis / Q000378:metabolism*; D039682:HIV-Associated Lipodystrophy Syndrome / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D006785:Hospitals, University; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009820:Ohio; D010865:Pilot Projects; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
D000975:Antioxidants; D008055:Lipids; D018894:Reverse Transcriptase Inhibitors; D014810:Vitamin E; D002784:Cholesterol; D005947:Glucose; D001205:Ascorbic Acid; D000111:Acetylcysteine