Distribution of ventilation in lung transplant recipients: evaluation by dynamic 3He-MRI with lung motion correction.
OBJECTIVE
The ability of motion corrected dynamic 3He-magnetic resonance imaging (MRI) to discriminate distributional patterns of inhaled hyperpolarized 3He between different groups of lung transplant recipients was evaluated.


METHODS
An ultrafast low-angle shot 2D sequence (temporal resolution 128 ms) was used for ventilation 3He-MRI of 11 single and 6 double lung transplant recipients. After digital motion correction, signal kinetics were evaluated in a tracheal and 7 pulmonary regions of interest. Results from grafts and native lungs as well as from normal and rejected grafts were compared with each other and to reference values from healthy subjects.


RESULTS
In emphysema patients, median alveolar rise time, a parameter for increase of alveolar signal, was 0.28 seconds for the graft and 0.48 seconds for the native lung, in fibrosis patients its median was 0.46 seconds for the graft and 0.21 seconds for the native lung. In double lung recipients, alveolar rise time was 0.29 seconds in normal and clinically rejected grafts.


CONCLUSIONS
Dynamic ventilation 3He-MRI discriminated normal lung grafts from diseased native lungs in single lung recipients. Graft rejection in double lung recipients could not be discriminated.
Gast
Klaus Kurt
KK
Department of Radiology, Klinikum Universitaet Mainz, Mainz, Germany. kgast@radiologie.klinik.uni-mainz.de
Puderbach
Michael Ulrich
MU
Rodriguez
Ignacio
I
Eberle
Balthasar
B
Markstaller
Klaus
K
Knitz
Frank
F
Schmiedeskamp
Joerg
J
Weiler
Norbert
N
Schreiber
Wolfgang G
WG
Mayer
Eckhardt
E
Thelen
Manfred
M
Kauczor
Hans-Ulrich
HU
D005260:Female; D006371:Helium; D006801:Humans; D007554:Isotopes; D008168:Lung / Q000033:anatomy & histology*; D016040:Lung Transplantation; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009038:Motion; D011656:Pulmonary Emphysema / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000473:pathology; D014692:Ventilation-Perfusion Ratio
D007554:Isotopes; D006371:Helium