Evaluation of nucleotide derivatives and sugar nucleotide analogs as inhibitors of glycosyltransferases.
The inhibition of glycosyltransferases was studied using uridine monophosphate derivatives and uridine diphosphate sugar analogs. Modification in the nucleoside portion caused selective inhibition of glycosyltransferases.
Osumi
K
K
Research Department, Noguchi Institute, 1-8-1, Kaga, Itabashi-ku, Tokyo 173-0003, Japan.
Kawauchi
N
N
Lu
A H
AH
Hindsgaul
O
O
Palcic
M M
MM
D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D016695:Glycosyltransferases / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D007700:Kinetics; D017351:N-Acetylglucosaminyltransferases / Q000037:antagonists & inhibitors; D009711:Nucleotides / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014530:Uridine Diphosphate / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D014542:Uridine Monophosphate / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology
D004791:Enzyme Inhibitors; D009711:Nucleotides; D014530:Uridine Diphosphate; D014542:Uridine Monophosphate; D016695:Glycosyltransferases; D017351:N-Acetylglucosaminyltransferases; C052254:alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase