title: Design, synthesis, and biological properties of highly potent epothilone B analogues.
authors.affiliation: Department of Chemistry and, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. kcn@scripps.edu
authors.forename: K C
authors.initials: KC
authors.lastname: Nicolaou
authors.forename: Pradip K
authors.initials: PK
authors.lastname: Sasmal
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Rassias
authors.forename: Mali Venkat
authors.initials: MV
authors.lastname: Reddy
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Altmann
authors.forename: Markus
authors.initials: M
authors.lastname: Wartmann
authors.forename: Aurora
authors.initials: A
authors.lastname: O'Brate
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Giannakakou
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D015195:Drug Design; D004351:Drug Resistance; D004354:Drug Screening Assays, Antitumor; D034261:Epothilones / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D017239:Paclitaxel / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D034261:Epothilones; D017239:Paclitaxel; C093788:epothilone B