title: Community-acquired Klebsiella pneumoniae central nervous system infections in adults in Singapore.
abstract: A series of successfully managed community-acquired Klebsiella pneumoniae infections of the central nervous system (CNS) that occurred in six non-neurosurgical adult patients in Singapore over a 2-year period is reported. Three patients had abscesses that were drained, and three had meningitis; all were treated with third-generation cephalosporins. All six patients were middle-aged adults, three of whom were food handlers. Clinicians should be aware of Klebsiella pneumoniae as an important CNS pathogen, particularly in East Asia. Although third-generation cephalosporins have had a major impact on the outcome of Klebsiella pneumoniae CNS infections, the emergence of extended-spectrum beta-lactamase-producing strains may lead to their reduced efficacy in this clinical setting.
authors.affiliation: Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, 119074, Singapore, Singapore.
authors.forename: A G
authors.initials: AG
authors.lastname: Habib
authors.forename: P A
authors.initials: PA
authors.lastname: Tambyah
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents; D020806:Central Nervous System Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015994:Incidence; D007710:Klebsiella Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000302:isolation & purification*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment; D012494:Sampling Studies; D012846:Singapore / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents