title: Expression of cyclin-D1 in uveal malignant melanoma.
abstract: BACKGROUND
  Uveal malignant melanoma (MM) is characterized by a marked variability in biological behavior and by an unpredictable clinical course. Therefore the search for reliable prognostic parameters is active. In this study we investigated the immunohistochemical expression of cyclin D1, a cell cycle regulatory molecule, to analyze the possible significance of the protein in the prognostic evaluation of these neoplasms.
  
  
  METHODS
  Forty-five selected uveal MM were incubated with the anti-cyclin D-1 antibody; the findings were compared with the follow-up data, with the cell type and with the largest tumor dimension.
  
  
  RESULTS
  The overexpression of cyclin D1 was found to be inversely related to disease-free interval (p < 0.001) and to the spindle A/B tumors with good prognosis (p = 0.05). On the other hand, a direct correlation was found with epithelioid/spindle B melanomas with poor clinical course (p = 0.05) and with sclera infiltration (p = 0.01). No statistically significant relation emerged between cyclin D1 expression and LTD.
  
  
  CONCLUSIONS
  These data may suggest a possible role of the overexpression of cyclin D1 in the tumorigenesis of uveal MM and in the prognostic evaluation of these tumors, representing a useful tool to subclassify lesions with similar morphological features.
authors.affiliation: Pathology Section, Department of Biomorphologic and Functional Sciences, University of Naples Federico II, Italy.
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Errico
authors.forename: Stefania
authors.initials: S
authors.lastname: Staibano
authors.forename: Fausto
authors.initials: F
authors.lastname: Tranfa
authors.forename: Giulio
authors.initials: G
authors.lastname: Bonavolonta
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Lo Muzio
authors.forename: Pasquale
authors.initials: P
authors.lastname: Somma
authors.forename: Antonio
authors.initials: A
authors.lastname: Lucariello
authors.forename: Gelsomina
authors.initials: G
authors.lastname: Mansueto
authors.forename: Antonella
authors.initials: A
authors.lastname: D'Aponte
authors.forename: Gerardo
authors.initials: G
authors.lastname: Ferrara
authors.forename: Gaetano
authors.initials: G
authors.lastname: De Rosa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019938:Cyclin D1 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D014604:Uveal Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D019938:Cyclin D1