title: The ability of Candida spp. strains to induce production of tumor necrosis factor and interleukin-6 by whole blood cells.
abstract: The aim of this study was to investigate the ability of C. albicans, C. glabrata, C. kefyr, C. krusei, and C. parapsilosis to induce production of TNF and IL-6 by whole blood cells of healthy subjects. The highest secretion of TNF and IL-6 was obtained with the 10(7) cells mL(-1) and 10(5) mL(-1) heat killed Candida cells, respectively, for all the species of Candida tested. C. albicans was a better stimulator of TNF and C. glabrata was a better stimulator of IL-6 than other Candida spp. C. krusei was the weakest inductor of IL-6 production.
authors.affiliation: Department of Microbiology, Medical University of Wrocław, Poland.
authors.forename: Urszula
authors.initials: U
authors.lastname: Nawrot
authors.forename: Kryspina
authors.initials: K
authors.lastname: Grzybek-Hryncewicz
authors.forename: Anna
authors.initials: A
authors.lastname: Czarny
mesh_terms: D002175:Candida / Q000276:immunology*; D002478:Cells, Cultured; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000276:immunology
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha