title: Enantioselective hydrogenation of tetrasubstituted olefins of cyclic beta-(acylamino)acrylates.
abstract: Hydrogenation of a series of cyclic beta-(acylamino)acrylates with tetrasubstituted olefins has been accomplished successfully with the use of Ru catalysts with chiral biaryl ligands such as C3-TunaPhos, and up to over 99% ee's have been achieved. This methodology provides an efficient catalytic method for the synthesis of both cis and trans chiral cyclic beta-amino acid derivatives.
authors.affiliation: Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Tang
authors.forename: Shulin
authors.initials: S
authors.lastname: Wu
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000598:Amino Acids, Cyclic / Q000138:chemical synthesis*; D003516:Cycloparaffins / Q000737:chemistry*; D006865:Hydrogenation; D013237:Stereoisomerism
chemical_list: D000179:Acrylates; D000598:Amino Acids, Cyclic; D003516:Cycloparaffins