title: Synthesis and properties of N-t-butylaminoxyl nucleosides.
abstract: Novel purine nucleosides with a N-tert-butylhydroxylamino group at the 2-position of purine nucleus (1-3) were synthesized, which might prefer anti conformation and would not perturb DNA structure when incorporated into oligonucleotide. Oxidation of 1-3 by treatment with Ag2O or air afforded stable aminoxyl radicals (1'-3') and their properties were studied by EPR spectroscopy. 5-N-tert-butylhydroxylamino uridine (4) was also synthesized.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kaneko
authors.forename: Mariko
authors.initials: M
authors.lastname: Aso
authors.forename: Morihide
authors.initials: M
authors.lastname: Nakamura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Matsui
authors.forename: Noboru
authors.initials: N
authors.lastname: Koga
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suemune
mesh_terms: D004578:Electron Spin Resonance Spectroscopy; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013113:Spin Labels
chemical_list: D009705:Nucleosides; D013113:Spin Labels