title: Chemical synthesis of novel taurine-containing uridine derivatives.
abstract: Recently, novel taurine-containing uridine derivatives were discovered in mammalian mitochondrial tRNAs, and these modified ribonucleosides existed at the first position of the anti-codon. This paper describes the chemical synthesis of these novel uridine derivatives, 5-taurinomethyluridine (tau m5U) and 5-taurinomethyl-2-thiouridine (tau m5s2U). These taurine-containing uridine derivatives were synthesized in the good yields by the reaction of the corresponding 5-hydroxymethyluridine derivatives with taurine under basic conditions.
authors.affiliation: Department of Integrated Biosciences, Graduate School of Frontier Science, University of Tokyo, Bioscience Bldg 702, Kashiwa, Chiba 277-8562, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Wada
authors.forename: Tomomi
authors.initials: T
authors.lastname: Shimazaki
authors.forename: Shingo
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Otuki
authors.forename: Shinya
authors.initials: S
authors.lastname: Kurata
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kimitsuna
authors.initials: K
authors.lastname: Watanabe
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Saigo
mesh_terms: D002851:Chromatography, High Pressure Liquid; D019906:Nuclear Magnetic Resonance, Biomolecular; D013654:Taurine / Q000737:chemistry*; D014529:Uridine / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D013654:Taurine; D014529:Uridine