title: [FDG PET as an early nuclear medical diagnostic tool for aseptic wear-induced loosening of hip joint endoprostheses--a report of two cases].
abstract: To date, 2-[F-18]fluoro-2-deoxy-D-glucose PET (FDG PET) is used as a tool in oncology as well as myocardiological and cerebral functional diagnostics in the clinical routine. False positive results of tumor search imply new possibilities for use in diagnostics of inflammation. The two case reports presented here on aseptic loosening of endoprostheses caused by the rub of polyethylene with histological and immunohistological refurbishing call attention to the possible diagnostic valency of FDG PET as an early warning system regarding aseptic artificial limb loosening induced by the rub of polyethylene. By quantification of glucose metabolism with the "standard uptake value" (SUV) as well as specific storage samples from around the artificial limb, it is the aim of our study group in further examinations to develop an algorithm which permits to distinguish between septic and aseptic loosening.
authors.affiliation: Orthopädische Klinik, UK Aachen. torsten.mumme@gmx.de
authors.forename: T
authors.initials: T
authors.lastname: Mumme
authors.forename: U
authors.initials: U
authors.lastname: Cremerius
authors.forename: B
authors.initials: B
authors.lastname: Hermanns
authors.forename: M
authors.initials: M
authors.lastname: Neuss
authors.forename: R
authors.initials: R
authors.lastname: Müller-Rath
authors.forename: U
authors.initials: U
authors.lastname: Büll
authors.forename: D C
authors.initials: DC
authors.lastname: Wirtz
mesh_terms: D000077:Acetabulum / Q000000981:diagnostic imaging; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D042241:Early Diagnosis; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D019788:Fluorodeoxyglucose F18; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging*; D011475:Prosthesis Failure; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18