title: Detection of cervical intraepithelial neoplasia in women with atypical squamous or glandular cells of undetermined significance cytology: a prospective study.
abstract: BACKGROUND
  (1) To assess the prevalence of histologically confirmed cervical intraepithelial neoplasia in patients with cervical smears diagnosed as atypical squamous or glandular cells of undetermined significance. (2) To evaluate the role of colposcopy and the presence of human papillomavirus in detecting underlying cervical intraepithelial neoplasia.
  
  
  METHODS
  In this prospective cohort, 148 women with atypical squamous or glandular cells of undetermined significance were evaluated by colposcopy, histological sampling, and human papillomavirus deoxyribonucleic acid testing.
  
  
  RESULTS
  Histological diagnosis of >/= cervical intraepithelial neoplasia II was found in 10/148 women. Women with a histological >/= cervical intraepithelial neoplasia II had a higher prevalence of >/= two abnormal quadrants (90% vs. 38%</= cervical intraepithelial neoplasia I, p = 0.002) and of high/intermediate-risk human papillomavirus (90% vs. 42% </= cervical intraepithelial neoplasia I, p = 0.005).
  
  
  CONCLUSIONS
  Our study shows that premalignant lesions of the cervix were present in 7% of the patients with a cytological diagnosis of atypical squamous or glandular cells of undetermined significance. Colposcopy and human papillomavirus deoxyribonucleic acid testing are both important parameters in detecting >/= cervical intraepithelial neoplasia II.
authors.affiliation: Department of Obstetrics and Gynecology, the Medical Center Haaglanden, Westeinde Hospital, the Hague, The Netherlands. Wenscel@euronet.nl
authors.forename: Celesta
authors.initials: C
authors.lastname: Wensveen
authors.forename: Marjolein
authors.initials: M
authors.lastname: Kagie
authors.forename: Roel
authors.initials: R
authors.lastname: Veldhuizen
authors.forename: Christianne
authors.initials: C
authors.lastname: De Groot
authors.forename: Lynette
authors.initials: L
authors.lastname: Denny
authors.forename: Koos
authors.initials: K
authors.lastname: Zwinderman
authors.forename: Baptist
authors.initials: B
authors.lastname: Trimbos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000821:virology; D003127:Colposcopy / Q000592:standards*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009426:Netherlands / Q000453:epidemiology; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D011237:Predictive Value of Tests; D015995:Prevalence; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology / Q000821:virology
chemical_list: D004279:DNA, Viral