title: [Immune mechanisms in HIV infection and their role in antiretroviral therapy].
abstract: In this article mechanisms of CD4 cells depletion, apoptosis, necrosis and T-cell activation, cellular immune responses to HIV infection, with emphasis on involvement of CD4 and CD8 HIV-specific cytotoxic T lymphocytes in human immunodeficiency virus infection are being discussed. Author reviews recent reports on immune restoration resulting from antiretroviral therapy, T-cell turnover within CD4 and CD8 subsets, including rapidly (activated effector and memory) and slowly (naïve) proliferating T-cells and the influence of IL-7 on regeneration of T lymphocytes. Finally function of dendritic cells in pathomechanisms of HIV disease is summarized.
authors.affiliation: Klinika Chorób Zakaźnych Instytutu Chorób Wewnetrznych Akademii Medycznej w Gdańsku.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Smiatacz
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D015704:CD4 Antigens / Q000276:immunology*; D016827:CD8 Antigens / Q000276:immunology*; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D015851:Interleukin-7 / Q000276:immunology*
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens; D015851:Interleukin-7