title: Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer's disease trial.
abstract: This article describes the development of the protocol for the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Alzheimer's disease trial, which was developed in collaboration with the National Institute of Mental Health to assess the effectiveness of atypical antipsychotics for psychosis and/or agitation occurring in outpatients with Alzheimer's disease. The article provides a detailed description of the methodology used in the trial as well as the clinical outcomes and effectiveness measures incorporated into it, discussing the most salient issues encountered in developing the design of the trial, as well as the unique features of the trial.
authors.affiliation: Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA. lschneid@usc.edu
authors.forename: Lon S
authors.initials: LS
authors.lastname: Schneider
authors.forename: M Saleem
authors.initials: MS
authors.lastname: Ismail
authors.forename: Karen
authors.initials: K
authors.lastname: Dagerman
authors.forename: Sonia
authors.initials: S
authors.lastname: Davis
authors.forename: Jason
authors.initials: J
authors.lastname: Olin
authors.forename: Dennis
authors.initials: D
authors.lastname: McManus
authors.forename: Eric
authors.initials: E
authors.lastname: Pfeiffer
authors.forename: J Michael
authors.initials: JM
authors.lastname: Ryan
authors.forename: David L
authors.initials: DL
authors.lastname: Sultzer
authors.forename: Pierre N
authors.initials: PN
authors.lastname: Tariot
mesh_terms: D000368:Aged; D000465:Algorithms; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004311:Double-Blind Method; D006801:Humans; D010043:Outcome and Process Assessment, Health Care; D011595:Psychomotor Agitation / Q000188:drug therapy* / Q000209:etiology*; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000209:etiology*; D016032:Randomized Controlled Trials as Topic / Q000592:standards*
chemical_list: D014150:Antipsychotic Agents