title: Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease.
abstract: We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP-1) and CC chemokine receptor (CCR)-2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP-1 -2518A/G genotype affected the age-at-onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP-1 in PD.
authors.affiliation: Department of Clinical Neuroscience, Tokushima University Hospital, Tokushima, Japan. mnishim@clin.tokushima-u.ac.jp
authors.forename: Masataka
authors.initials: M
authors.lastname: Nishimura
authors.forename: Sadako
authors.initials: S
authors.lastname: Kuno
authors.forename: Ikuko
authors.initials: I
authors.lastname: Mizuta
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Ohta
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Maruyama
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kaji
authors.forename: Hideshi
authors.initials: H
authors.lastname: Kawakami
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D018932:Chemokine CCL2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D018932:Chemokine CCL2