[TCR-mediated signaling].
In recent years, major progress has been obtained in studying the early events in TCR-mediated signaling. c-Cb1 has been found to be a negative regulatory factor of the tyrosine kinases in ZAP-70/SyK family. The studies on LAT, SLP-76, ItK and Vav have shown their roles in the signal transduction of Ras and phospholipase Cx1 to Ca2+. Micro-glycolipid raft also plays important role in T cell activation. This minireview shows a brief introduction to the process of TCR-mediated signaling.
Yang
Chun
C
Department of Clinical Medicine, PUMC, Beijing 100730, China.
Zhu
Li-ping
LP
Zhang
Wei
W
D000818:Animals; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D050721:Proto-Oncogene Proteins c-cbl; D011948:Receptors, Antigen, T-Cell / Q000276:immunology* / Q000502:physiology; D015398:Signal Transduction / Q000276:immunology* / Q000502:physiology; D044767:Ubiquitin-Protein Ligases
D011518:Proto-Oncogene Proteins; D011948:Receptors, Antigen, T-Cell; D050721:Proto-Oncogene Proteins c-cbl; D044767:Ubiquitin-Protein Ligases; C067419:CBL protein, human