Single-dose pharmacokinetics of ofloxacin during continuous venovenous hemofiltration in critical care patients.
BACKGROUND
Ofloxacin is a quinolone administered to patients with severe infections. Pharmacokinetic data on ofloxacin in critically ill patients on renal replacement therapy are sparse and conflicting.


METHODS
Eight patients with anuric acute renal failure were administered 400 mg of ofloxacin intravenously. The pharmacokinetics of ofloxacin was analyzed during continuous venovenous hemofiltration (CVVH) with a high-flux polysulfone membrane. Serum and ultrafiltrate levels of ofloxacin were measured by means of high-performance liquid chromatography.


RESULTS
Mean serum ofloxacin concentration peak was 5.5 +/- 0.7 mg/L. Elimination half-life, hemofiltration clearance, and total removal were 2.8 +/- 0.5 hours, 89.9 +/- 4.5 mL/min, and 76.9% +/- 7.1%, respectively.


CONCLUSIONS
Ofloxacin is significantly and rapidly eliminated by CVVH with a high-flux polysulfone membrane.
Fuhrmann
Valentin
V
Department of Internal Medicine 4, Intensive Care Unit, University of Vienna, Allgemeines Krankenhaus, Waehringer Guertel, Vienna, Austria.
Schenk
Peter
P
Mittermayer
Christoph
C
El Menyawi
Ibrahim
I
Ratheiser
Klaus
K
Thalhammer
Florian
F
D058186:Acute Kidney Injury / Q000150:complications / Q000188:drug therapy*; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D003422:Critical Care; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000150:complications / Q000188:drug therapy*; D006207:Half-Life; D006440:Hemofiltration; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D015242:Ofloxacin / Q000493:pharmacokinetics* / Q000627:therapeutic use
D000890:Anti-Infective Agents; D015242:Ofloxacin