Identification of the hypervirulent lineages of Neisseria meningitidis, the ST-8 and ST-11 complexes, by using monoclonal antibodies specific to NmeDI.
Most cases of serogroup C meningococcal disease are caused by the clonal lineages ST-8 and ST-11. The gene encoding the putative restriction-modification system NmeDI is specific to these lineages. We report here a monoclonal antibody directed against the NmeDI endonuclease as a tool for their rapid and spe-cific identification.
Claus
Heike
H
Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany.
Weinand
Hanne
H
Frosch
Matthias
M
Vogel
Ulrich
U
D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D015373:Bacterial Typing Techniques; D002353:Carrier State / Q000382:microbiology; D006801:Humans; D009345:Neisseria meningitidis / Q000145:classification / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D015183:Restriction Mapping; D014774:Virulence
D000911:Antibodies, Monoclonal