RNA as a transcriptional activator.
Two recent reports demonstrate that in vivo selection can isolate novel RNAs that activate transcription when tethered to a gene promoter. This highlights the structural plasticity that allows RNA to fulfill many functions normally carried out by proteins.
Gottesfeld
Joel M
JM
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Barbas
Carlos F
CF
D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D009154:Mutation / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics; D012313:RNA / Q000737:chemistry / Q000494:pharmacology*; D014157:Transcription Factors; D014158:Transcription, Genetic / Q000187:drug effects*
D014157:Transcription Factors; D012313:RNA