Bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP): structure, function and regulation in host defence against Gram-negative bacteria.
Lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI) are closely related endotoxin-binding proteins that function in a co-ordinated manner to facilitate an integrated host response to invading Gram-negative bacteria. Differences in the structure and function of BPI and LBP, as well as differences in their mobilization, permit highly sensitive pro-inflammatory responses to small numbers of bacteria at the onset of bacterial invasion and, later, efficient elimination of viable bacteria and their remnants and of endotoxin-driven inflammation.
Weiss
J
J
Departments of Internal Medicine and Microbiology, Division of Infectious Diseases and The Inflammation Program, Roy J. and Lucille A. Carver, College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA. jerrold-weiss@uiowa.edu
D000209:Acute-Phase Proteins; D000818:Animals; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins / Q000737:chemistry / Q000276:immunology*; D002352:Carrier Proteins / Q000737:chemistry / Q000276:immunology*; D004731:Endotoxins / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism; D016905:Gram-Negative Bacterial Infections / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D008958:Models, Molecular; D013329:Structure-Activity Relationship; D000099231:Lipopolysaccharide-Binding Protein
D000209:Acute-Phase Proteins; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D002352:Carrier Proteins; D004731:Endotoxins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D000099231:Lipopolysaccharide-Binding Protein; C021623:bactericidal permeability increasing protein