After Hrs with HIV.
To efficiently bud off from infected cells, HIV and other enveloped viruses hijack the host cellular machinery that is normally involved in vacuolar protein sorting and multivesicular body (MVB) biogenesis. The HIV Gag protein mimics hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs), a modular adaptor protein that links membrane cargo recognition to its degradation after delivery to MVBs. In contrast to T cells, where HIV budding occurs at the plasma membrane, virus buds into vacuoles of macrophages, a process that may facilitate its spread within the infected host.
Amara
Ali
A
Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Littman
Dan R
DR
D056827:Endosomal Sorting Complexes Required for Transport; D011992:Endosomes / Q000378:metabolism / Q000821:virology; D015683:Gene Products, gag / Q000378:metabolism*; D006678:HIV / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D008264:Macrophages / Q000378:metabolism / Q000821:virology*; D018716:Molecular Mimicry / Q000502:physiology; D010750:Phosphoproteins / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D014779:Virus Replication / Q000502:physiology*; D017201:Virus Shedding / Q000502:physiology*; D054301:gag Gene Products, Human Immunodeficiency Virus
D056827:Endosomal Sorting Complexes Required for Transport; D015683:Gene Products, gag; D010750:Phosphoproteins; D054301:gag Gene Products, Human Immunodeficiency Virus; C083868:gag protein p1, Human immunodeficiency virus; C096164:hepatocyte growth factor-regulated tyrosine kinase substrate