title: Successful management of acute renal artery thromboembolism by intra-arterial thrombolytic therapy with recombinant tissue plasminogen activator.
abstract: Acute renal artery thromboembolism (ARAT), a rare event in native kidneys, potentially result in severe renal injury if it is not appropriately managed. The optimal therapy still remains controversial today even though various methods of managements for ARTA were applied in these decades including surgical intervention and medical approach such as thrombolytic therapy. Recombinant tissue plasminogen activator (rt-PA) reveals a better bioavailability and lower incidence of adverse effects and it has been widely used to treat a number of clinical conditions but only very few cases have been reported where rt-PA was used to treat ARAT. We described a case of ARAT, which was successfully treated by the administration of rt-PA via intra-arterial infusion within a period of 60 min without residual renal impairment. It may be a useful choice for ARAT and renal infarction sufferers.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC.
authors.forename: Ben-Chung
authors.initials: BC
authors.lastname: Cheng
authors.forename: Sheung-Fat
authors.initials: SF
authors.lastname: Ko
authors.forename: Feng-Rong
authors.initials: FR
authors.lastname: Chuang
authors.forename: Chih-Hsiung
authors.initials: CH
authors.lastname: Lee
authors.forename: Jin-Bor
authors.initials: JB
authors.lastname: Chen
authors.forename: Kuo-Tai
authors.initials: KT
authors.lastname: Hsu
mesh_terms: D000208:Acute Disease; D000328:Adult; D019468:Disease Management; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging / Q000188:drug therapy*; D013923:Thromboembolism / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator