title: Synthesis of amide compounds of ferulic acid, and their stimulatory effects on insulin secretion in vitro.
abstract: We prepared amide compounds which were derived from ferulic acid using various amines, and investigated their stimulatory effects on insulin secretion using rat pancreatic RIN-5F cells. Most of these compounds exhibited significant promotion of the insulin-release at a concentration of 10 microM and in particular, the amides having n-butyl, n-pentyl, pyrrolidine, and piperidine groups showed high activity.
authors.affiliation: Industrial Technology Center of Wakayama Prefecture, 60 Ogura, 649-6261, Wakayama, Japan. nomura@wakayama-kg.go.jp
authors.forename: Eisaku
authors.initials: E
authors.lastname: Nomura
authors.forename: Ayumi
authors.initials: A
authors.lastname: Kashiwada
authors.forename: Asao
authors.initials: A
authors.lastname: Hosoda
authors.forename: Kozo
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hideko
authors.initials: H
authors.lastname: Morishita
authors.forename: Takuo
authors.initials: T
authors.lastname: Tsuno
authors.forename: Hisaji
authors.initials: H
authors.lastname: Taniguchi
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D002470:Cell Survival; D003373:Coumaric Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007328:Insulin / Q000096:biosynthesis*; D051381:Rats
chemical_list: D000577:Amides; D003373:Coumaric Acids; D007328:Insulin; C004999:ferulic acid