Metoclopramide and unintended weight gain.
OBJECTIVE
This paper describes the case of a 19-year-old female with anorexia nervosa (restricting type) who was prescribed metoclopramide (Reglan, Robins, Richmond, VA) for delayed gastric emptying. She subsequently experienced dramatic and unintended weight gain.


RESULTS
The initial treatment of delayed gastric emptying with metoclopramide did not result in a significant change in body weight. However, an increase in the dose resulted in a 20% increase in the patient's body weight over a 2-month period.


CONCLUSIONS
The risks of weight gain that accompany the administration of metoclopramide are discussed, as well as the postulated etiology and psychological implications for the patient.
Sansone
Randy A
RA
Department of Psychiatry, Wright State University School of Medicine, Dayton, Ohio, USA. Randy.sansone@kmcnetwork.org
Sansone
Lori A
LA
D000328:Adult; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D000932:Antiemetics / Q000009:adverse effects* / Q000627:therapeutic use; D001824:Body Constitution; D001828:Body Image; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D018589:Gastroparesis / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008787:Metoclopramide / Q000009:adverse effects* / Q000627:therapeutic use; D011320:Primary Health Care; D015430:Weight Gain / Q000187:drug effects*
D000932:Antiemetics; D008787:Metoclopramide