title: Neuropharmacological activity of Nigella sativa L. extracts.
abstract: Pharmacological studies have been conducted on the aqueous and methanol extracts of defatted Nigella sativa L. seeds to evaluate their effects on the central nervous system (CNS) and on analgesic activity. The observations suggest that the two extracts of Nigella sativa possesses a potent CNS and analgesic activity (depressant action especially in the case of the methanolic extract).
authors.affiliation: Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
authors.forename: T B
authors.initials: TB
authors.lastname: Al-Naggar
authors.forename: M P
authors.initials: MP
authors.lastname: Gómez-Serranillos
authors.forename: M E
authors.initials: ME
authors.lastname: Carretero
authors.forename: A M
authors.initials: AM
authors.lastname: Villar
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005106:Exploratory Behavior / Q000187:drug effects; D006358:Hot Temperature; D007274:Injections, Intraperitoneal; D000432:Methanol; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009480:Neuropharmacology / Q000379:methods; D031881:Nigella sativa; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement / Q000379:methods; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use*; D045442:Rotarod Performance Test; D012639:Seeds / Q000737:chemistry; D013030:Spain; D014867:Water
chemical_list: D010936:Plant Extracts; D014867:Water; D000432:Methanol