title: Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBF.
abstract: The ribosomal DNA transcription-specific factor, UBF, is a key target for the regulation of ribosomal RNA synthesis and hypertrophic growth of isolated neonatal cardiomyocytes. In this study, we have examined whether UBF expression is also an important determinant of cardiac growth rates in vivo. We show that rDNA transcription, rRNA synthesis and UBF expression in left ventricular myocytes isolated from mice 1-6 weeks following transverse aortic constriction were significantly increased (2.5-3.5-fold) compared to the levels in myocytes from the left ventricle of sham-operated mice.
authors.affiliation: Molecular Cardiology, Baker Heart Research Institute, P.O. Box 6492, St Kilda Road Central, Melbourne, Vic., 8008, Australia.
authors.forename: Yves
authors.initials: Y
authors.lastname: Brandenburger
authors.forename: Jane F
authors.initials: JF
authors.lastname: Arthur
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Woodcock
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Du
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Gao
authors.forename: Dominic J
authors.initials: DJ
authors.lastname: Autelitano
authors.forename: Lawrence I
authors.initials: LI
authors.lastname: Rothblum
authors.forename: Ross D
authors.initials: RD
authors.lastname: Hannan
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics; D006332:Cardiomegaly / Q000209:etiology / Q000473:pathology*; D006352:Heart Ventricles / Q000473:pathology; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000473:pathology; D051379:Mice; D032342:Muscle Cells / Q000473:pathology; D035463:Pol1 Transcription Initiation Complex Proteins / Q000096:biosynthesis* / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D012335:RNA, Ribosomal / Q000096:biosynthesis; D014158:Transcription, Genetic; D015854:Up-Regulation
chemical_list: D035463:Pol1 Transcription Initiation Complex Proteins; D012333:RNA, Messenger; D012335:RNA, Ribosomal; C063844:transcription factor UBF; D009320:Atrial Natriuretic Factor