Interleukin-18 serum concentration in patients with psoriasis triggered by infection.
The blood serum concentrations of IL-18 and the subpopulation of blood lymphocytes in peripheral blood were investigated in 14 patients with psoriasis preceded by a bacterial infection. The IL-18 concentrations were measured with the ELISA method, and the lymphocyte subpopulation--by flow cytometry. The elevated IL-18 concentrations in blood serum were observed; however, the increase was statistically insignificant in the group of psoriatic patients in comparison with the control (p > 0.4). The result of flow cytometry showed that a statistically significant increase of the percentage of CD45RO4 and CD45RO cells, and a statistically significant decrease of MFI expression of CD19+ and CD3+ cells (p < 0.004; p < 0.02; p < 0.05; p < 0.05) occurred in the patients.
Pietrzak
Aldona
A
Department of Dermatology, Department of Clinical Immunology, Medical University of Lublin.
Lecewicz-Toruń
Barbara
B
Roliński
Jacek
J
D000328:Adult; D001424:Bacterial Infections / Q000150:complications*; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D011565:Psoriasis / Q000097:blood* / Q000209:etiology*
D020382:Interleukin-18