title: Psychosocial distress during pregnancy and the risk of infantile colic: a follow-up study.
abstract: OBJECTIVE
  To examine the association between psychosocial exposures during pregnancy and the risk of infantile colic.
  
  
  METHODS
  The study included 378 infants and was conducted as a substudy of the Danish National Birth Cohort from 1997 to 1999, with prenatal data collected twice during pregnancy. A diary with a record for postpartum weeks 4-8 was used to quantify the amount of the infants' crying and fussing.
  
  
  RESULTS
  The cumulative incidence proportion of infantile colic was 8.2%. A threefold increased risk of infantile colic (OR = 3.7; 95% CI: 1.1-13.2) was found for mothers who reported distress during pregnancy. Close to a twofold increased risk of IC was found for the women who scored higher than 8 on the psychological distress scale (adjusted OR = 1.9; 95% CI: 0.5-7.2).
  
  
  CONCLUSIONS
  The results indicate that general distress during pregnancy influences the risk of infantile colic. Whether or not this relationship is causal requires further investigations.
authors.affiliation: The Danish Epidemiology Science Centre, University of Aarhus, Denmark. cos@dadlnet.dk
authors.forename: C
authors.initials: C
authors.lastname: Søndergaard
authors.forename: J
authors.initials: J
authors.lastname: Olsen
authors.forename: E
authors.initials: E
authors.lastname: Friis-Haschè
authors.forename: M
authors.initials: M
authors.lastname: Dirdal
authors.forename: N
authors.initials: N
authors.lastname: Thrane
authors.forename: H Toft
authors.initials: HT
authors.lastname: Sørensen
mesh_terms: D000328:Adult; D003085:Colic / Q000453:epidemiology*; D003863:Depression / Q000453:epidemiology* / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008016:Life Change Events; D008499:Medical Records; D009035:Mothers / Q000523:psychology* / Q000706:statistics & numerical data*; D010500:Perinatology; D011247:Pregnancy; D011248:Pregnancy Complications; D011584:Psychology; D011795:Surveys and Questionnaires