title: Secondary rifampin resistance following multi-drug therapy--a case report.
abstract: This is the first report of secondary resistance to rifampin following MDT in a patient with prolonged, but irregular treatment. Repeated mouse foot-pad studies demonstrated resistance to dapsone after several years of monotherapy, and following subsequent MDT the studies demonstrated the development of resistance to rifampin.
authors.affiliation: Department of Community Health, Schieffelin Leprosy Research and Training Center, Karigiri, Vellore-632106, India. oculep@vsnl.com
authors.forename: Gift
authors.initials: G
authors.lastname: Norman
authors.forename: Geetha
authors.initials: G
authors.lastname: Joseph
authors.forename: Gigi
authors.initials: G
authors.lastname: Ebenezer
authors.forename: Sundar P
authors.initials: SP
authors.lastname: Rao
authors.forename: Charles K
authors.initials: CK
authors.lastname: Job
mesh_terms: D003622:Dapsone / Q000494:pharmacology / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple; D004359:Drug Therapy, Combination; D006801:Humans; D007917:Leprostatic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D007918:Leprosy / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D007917:Leprostatic Agents; D003622:Dapsone; D012293:Rifampin