[Expressions of chloride channel ClC-2 and ClC-3 in human nasal polyps].
OBJECTIVE
To investigate the role of chloride channel ClC-2 and ClC-3 in human nasal polyps.


METHODS
Two chloride channels ClC-2 and ClC-3 were studied in 27 cases of nasal polyps with immunochemistric staining.


RESULTS
Nasal polyps revealed strong positive staining of ClC-2 and ClC-3, the ClC-2 and ClC-3 proteins localized mainly in epithelial cells, sub-epithelial mucous glands without significant distinction. The number of positive cells of ClC-2 and ClC-3 are 17.6 +/- 6.33 and 23.49 +/- 6.14.


CONCLUSIONS
The chloride channels ClC-2 and ClC-3 may play a role in the formation of nasal polyps.
Li
Huabin
H
Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing Institute of Otolaryngology, Beijing 100005.
Han
Demin
D
Zhou
Bing
B
Fan
Erzhong
E
Liu
Zhongyan
Z
D000328:Adult; D018118:Chloride Channels / Q000096:biosynthesis*; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism*
D018118:Chloride Channels; C115376:ClC-3 channel