Rodent models for ovarian cancer research.
Animal models that are biologically and clinically relevant are essential for conducting research to investigate the pathophysiologic progression of disease and to develop diagnostic or therapeutic strategies. Several rodent models that vary in methods of induction allow appropriate in vivo evaluation for ovarian cancer. The types of rodent models discussed include chemically (nonhormonal and hormonal) induced, genetic (knockout and transgenic), xenograft, and syngeneic. A summary of the available rodent models is provided with a discussion of the advantages and disadvantages of each. Optimization and application of these rodent models to future research may benefit the detection and treatment of ovarian cancer.
Stakleff
K D Sloan
KD
Kenneth Calhoun Research Laboratory, Akron General Medical Center, Akron, Ohio USA. kstakleff@agmc.org
Von Gruenigen
V E
VE
D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008822:Mice, Transgenic; D009374:Neoplasms, Experimental; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000473:pathology; D012107:Research Design; D012377:Rodentia; D012680:Sensitivity and Specificity; D014183:Transplantation, Heterologous