title: Effects of ELF and static magnetic fields on calcium oscillations in islets of Langerhans.
abstract: Several experimental studies have produced contradictory results on the effects of extremely low frequency (ELF) magnetic fields on cellular processes involving calcium ions. Furthermore, the few positive results have not been independently replicated. In most of these studies, isolated cells were used. Our study used mouse islets of Langerhans, in which very regular oscillations of calcium concentration can be observed at length. These oscillations are sustained by processes that imply energetic and inter-intracellular communication. Various magnetic fields were applied, either sinusoidal at different frequencies (50 Hz or multiples of the natural oscillation frequency) at 0.1 or 1 mT or static at 1 mT. Islets were also exposed to "cyclotron resonance" conditions. There was neither alteration of the fundamental oscillation frequency nor the degree of organisation under all exposure conditions. Using this sensitive model, we could not show new evidence of alterations of calcium processes under exposure to various magnetic fields.
authors.affiliation: PIOM Laboratory, ENSCPB, University of Bordeaux 1, 16 Pey Berland Avenue, 33607 Cedex, Pessac, France.
authors.forename: F
authors.initials: F
authors.lastname: Madec
authors.forename: B
authors.initials: B
authors.lastname: Billaudel
authors.forename: R
authors.initials: R
authors.lastname: Charlet de Sauvage
authors.forename: P
authors.initials: P
authors.lastname: Sartor
authors.forename: B
authors.initials: B
authors.lastname: Veyret
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D002478:Cells, Cultured; D017357:Cyclotrons; D005260:Female; D007515:Islets of Langerhans / Q000502:physiology*; D008280:Magnetics; D051379:Mice; D008954:Models, Biological