title: In vitro biocompatibility evaluation of the dynamic bubble trap.
abstract: The goal of this study was to evaluate the biocompatibility of the dynamic bubble trap (DBT) prior to the clinical trial. It was set up as an in vitro model, which simulates physiological conditions. Twenty runs were performed (ten with the DBT, ten without the DBT) at a blood flow of 3 l/min, each lasting 180 min. Fifteen blood parameters (hemogram, hemostasis, complement system, and cytokines) were measured at five time intervals. None of the tested parameters showed a statistically significant difference between the DBT and control group. The data assessed in this in vitro model show that the DBT has no adverse influence on hemocompatibility. It may be concluded that the DBT is a safe tool to be used in vivo.
authors.affiliation: Kerckhoff-Klinik, Bad Nauheim, Augsburg, Germany. utaborski@aol.com
authors.forename: Uwe
authors.initials: U
authors.lastname: Taborski
authors.forename: Petr
authors.initials: P
authors.lastname: Urbanek
authors.forename: Gunther
authors.initials: G
authors.lastname: Erhardt
authors.forename: Markus
authors.initials: M
authors.lastname: Schönburg
authors.forename: Svetlana
authors.initials: S
authors.lastname: Basser
authors.forename: Larisa
authors.initials: L
authors.lastname: Wohlgemuth
authors.forename: Kathrin
authors.initials: K
authors.lastname: Heidinger
authors.forename: Wolf-Peter
authors.initials: WP
authors.lastname: Klövekorn
mesh_terms: D001792:Blood Platelets; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D066298:In Vitro Techniques; D007958:Leukocyte Count; D008422:Materials Testing; D045423:Microbubbles; D008954:Models, Biological