Duplex foldamers from assembly induced folding.
Oligoamide strands 1, 2, and 3, consisting of 4-H-bond units, were originally designed to form noncovalent polymers based on the expectation that they would adopt an extended conformation. Instead of assembling into the expected supramolecular polymer through their 4-H-bond units, the 1:1 mixture of 1 and 2 was found to form a highly stable dimeric species. To dimerize, the H-bonding sequences of 1 and 2 can only adopt a folded (stacked) conformation. The self-assembly of 3 was also found to adopt a similar folded duplex conformation. These novel duplex foldamers are very stable. They were characterized by 1D and 2D 1H NMR, VPO, and mass spectral (ESI) studies.
Yang
Xiaowu
X
Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
Martinovic
Suzana
S
Smith
Richard D
RD
Gong
Bing
B
D040761:Biomimetic Materials / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009757:Nylons / Q000737:chemistry*; D017510:Protein Folding
D009757:Nylons; D004247:DNA