Drosophila metabolize 1,4-butanediol into gamma-hydroxybutyric acid in vivo.
A solvent, 1,4-butanediol, is also abused as a recreational drug. In mammals, 1,4-butanediol is metabolized into gamma-hydroxybutyric acid (GHB), which stimulates metabotropic gamma-aminobutyric acid (GABA) GABAB and putative GHB receptors. Here we show that in vivo injection of 1,4-butanediol into adult Drosophila leads to GHB synthesis (GHB was detectable 5 min after 1,4-butanediol injection and increased dramatically 1-2 h later). This synthesis of GHB was accompanied by an impairment of locomotor activity that was mimicked by a direct injection of GHB into flies. We propose Drosophila as a model to study the molecular actions of 1,4-butanediol and GHB.
Satta
Rosalba
R
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA.
Dimitrijevic
Nikola
N
Manev
Hari
H
D000818:Animals; D002072:Butylene Glycols / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D012978:Sodium Oxybate / Q000378:metabolism*; D013997:Time Factors
D002072:Butylene Glycols; D012978:Sodium Oxybate; C039681:1,4-butanediol