title: Fatal sodium valproate-induced hypersensitivity syndrome with lichenoid dermatitis and fulminant hepatitis.
abstract: Anticonvulsant hypersensitivity syndrome caused by sodium valproate (Depakene) has rarely been reported. Here we describe a patient who presented with nonspecific polymorphous eruptions, fulminant hepatitis, and jaundice. Lichenoid dermatitis was found in the skin biopsy specimen. Toxic hepatitis and microvesicular steatosis were found in the liver biopsy specimen, consistent with valproate hepatotoxicity.
authors.affiliation: Department of Dermatology Chang Gung Memorial Hospital, Taipei, Taiwan.
authors.forename: Yau-Li
authors.initials: YL
authors.lastname: Huang
authors.forename: Hong-Shang
authors.initials: HS
authors.lastname: Hong
authors.forename: Zen-Whe
authors.initials: ZW
authors.lastname: Wang
authors.forename: Tseng-tong
authors.initials: TT
authors.lastname: Kuo
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017512:Lichenoid Eruptions / Q000139:chemically induced*; D017093:Liver Failure / Q000139:chemically induced*; D009207:Myoclonus / Q000188:drug therapy; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid