title: [TCR-mediated signaling].
abstract: In recent years, major progress has been obtained in studying the early events in TCR-mediated signaling. c-Cb1 has been found to be a negative regulatory factor of the tyrosine kinases in ZAP-70/SyK family. The studies on LAT, SLP-76, ItK and Vav have shown their roles in the signal transduction of Ras and phospholipase Cx1 to Ca2+. Micro-glycolipid raft also plays important role in T cell activation. This minireview shows a brief introduction to the process of TCR-mediated signaling.
authors.affiliation: Department of Clinical Medicine, PUMC, Beijing 100730, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Zhu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D050721:Proto-Oncogene Proteins c-cbl; D011948:Receptors, Antigen, T-Cell / Q000276:immunology* / Q000502:physiology; D015398:Signal Transduction / Q000276:immunology* / Q000502:physiology; D044767:Ubiquitin-Protein Ligases
chemical_list: D011518:Proto-Oncogene Proteins; D011948:Receptors, Antigen, T-Cell; D050721:Proto-Oncogene Proteins c-cbl; D044767:Ubiquitin-Protein Ligases; C067419:CBL protein, human