title: Does imprint cytology of brain tumours improve intraoperative diagnoses?
abstract: OBJECTIVE
  To evaluate the diagnostic accuracy using frozen sections only and a combination of imprint cytology and frozen sections.
  
  
  METHODS
  After introduction of imprint cytology as a supplement to frozen sections in 1999, 153 patients with brain tumours underwent stereotactic or open surgery. An equal number of cases prior to 1999 were chosen for comparison. Intraoperative diagnoses were compared with final diagnoses based on paraffin sections of the same tissue samples. The number of delayed intraoperative diagnoses was noted in each patient group.
  
  
  RESULTS
  The combined use of the two techniques improved intraoperative diagnostic accuracy from 87 to 91% while the delayed intraoperative diagnoses were significantly reduced from 30 to 8. The choice of surgical procedure did not affect the outcome of the pathological investigations.
  
  
  CONCLUSIONS
  A combination of frozen sections and imprints significantly reduced the number of delayed intraoperative diagnoses. Intraoperative diagnostic accuracy was improved, although not to a statistically significant level. Choice of surgical procedure did not affect the diagnostic outcome.
authors.affiliation: Department of Neurosurgery, University Hospital of Northern Norway, Tromsø, Norway. torbrom@frisurf.no
authors.forename: T
authors.initials: T
authors.lastname: Brommeland
authors.forename: S
authors.initials: S
authors.lastname: Lindal
authors.forename: B
authors.initials: B
authors.lastname: Straume
authors.forename: I L
authors.initials: IL
authors.lastname: Dahl
authors.forename: R
authors.initials: R
authors.lastname: Hennig
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002675:Child, Preschool; D003399:Craniotomy; D003937:Diagnosis, Differential; D005260:Female; D005629:Frozen Sections; D006801:Humans; D007223:Infant; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D016612:Paraffin Embedding; D012189:Retrospective Studies