title: Inhaled nitric oxide induces cerebrovascular effects in anesthetized pigs.
abstract: Although inhaled nitric oxide (NO(i)) is considered to act selectively on pulmonary vessels, EEG abnormalities and even occasional neurotoxic effects of NO(i) have been proposed. Here, we investigated cerebrovascular effects of increasing concentrations of 5, 10 and 50 ppm NO(i) in seven anesthetized pigs. Cerebral hemodynamics were assessed non-invasively by use of near-infared spectroscopy and indicator dilution techniques. NO(i) increased cerebral blood volume significantly and reversibly. This effect was not attributable to changes of macrohemodynamic parameters or arterial blood gases. Simultaneously, cerebral transit time increased while cerebral blood flow remained unchanged. These data demonstrate a vasodilatory action of NO(i) in the cerebral vasculature, which may occur preferentially in the venous compartment.
authors.affiliation: Institute for Surgical Research, University of Munich, Munich, Germany. kuebler@zedat.fr-berlin.de
authors.forename: W M
authors.initials: WM
authors.lastname: Kuebler
authors.forename: H
authors.initials: H
authors.lastname: Kisch-Wedel
authors.forename: G I
authors.initials: GI
authors.lastname: Kemming
authors.forename: F
authors.initials: F
authors.lastname: Meisner
authors.forename: S
authors.initials: S
authors.lastname: Bruhn
authors.forename: C
authors.initials: C
authors.lastname: Koehler
authors.forename: M
authors.initials: M
authors.lastname: Flondor
authors.forename: K
authors.initials: K
authors.lastname: Messmer
authors.forename: B
authors.initials: B
authors.lastname: Zwissler
mesh_terms: D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D002536:Cerebral Arteries / Q000187:drug effects* / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D004333:Drug Administration Routes; D005260:Female; D006439:Hemodynamics; D008297:Male; D009569:Nitric Oxide / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D034421:Sus scrofa; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology
chemical_list: D000777:Anesthetics; D009569:Nitric Oxide