title: Case report: Schistosoma mansoni infection: failure of standard treatment with praziquantel in a returned traveller.
abstract: Heavy reliance upon praziquantel for the treatment of schistosomiasis raises concerns over potential development of drug resistance. We describe a British traveller who acquired Schistosoma mansoni infection in East Africa and in whom repeated standard 40 mg/kg doses of praziquantel failed to clear the infection despite no opportunity for reinfection.
authors.affiliation: Hospital for Tropical Diseases, London, UK. stevelawn@yahoo.co.uk
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Lawn
authors.forename: Sebastian B
authors.initials: SB
authors.lastname: Lucas
authors.forename: Peter L
authors.initials: PL
authors.lastname: Chiodini
mesh_terms: D000328:Adult; D000871:Anthelmintics / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D008297:Male; D011223:Praziquantel / Q000627:therapeutic use*; D012555:Schistosomiasis mansoni / Q000188:drug therapy*; D014195:Travel; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D011223:Praziquantel