title: [Abnormal chromatin clumping syndrome during treatment with mycophenolate mofetil].
abstract: We describe an abnormal chromatin clumping phenomenon (ACC) with nuclear loss of segmentation on circulating neutrophils in three patients receiving mycophenolate mofetil (Cellcept). It is worth being aware of this rare adverse event because of its unknown origin and of its possible clinical consequences.
authors.affiliation: Service d'hématologie biologique, Hôpital européen Georges Pompidou, Paris. Davis.SMADJA@hop.egp.ap-hop-paris.fr
authors.forename: D
authors.initials: D
authors.lastname: Smadja
authors.forename: P
authors.initials: P
authors.lastname: Lemaire
authors.forename: N
authors.initials: N
authors.lastname: Atkhen
mesh_terms: D000328:Adult; D000368:Aged; D042002:Chromatin Assembly and Disassembly / Q000187:drug effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000009:adverse effects* / Q000031:analogs & derivatives*; D009504:Neutrophils / Q000473:pathology*; D013577:Syndrome
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid