title: Metabolite changes resulting from treatment in children with ADHD: a 1H-MRS study.
abstract: Previously the authors noted an increase in glutamatergic tone in children with attention deficit hyperactivity disorder compared with age- and gender-matched control subjects. In this study they examine the effect of treatment on metabolite concentrations. Fourteen children with attention deficit hyperactivity disorder were investigated medication free and after treatment, using proton magnetic resonance spectroscopy. In the prefrontal cortex and striatum, metabolite peaks of N-acetyl-aspartate, glutamate/glutamine/gamma-aminobutyric acid, creatine/phosphocreatine, and choline compounds were measured, and ratios of the peaks were calculated and compared before and after treatment. The glutamate/glutamine/gamma-aminobutyric acid-to-creatine/phosphocreatine ratio decreased significantly in the striatum. No other metabolites demonstrated any change in response to medication. These findings suggest that glutamate may be involved in treatment response in attention deficit hyperactivity disorder, especially in the striatum.
authors.affiliation: Maritime Psychiatry, IWK Health Centre, 5850 University Avenue, Halifax, Nova Scotia, Canada B3J 3G9. Normand.Carrey@iwk.nshealth.ca
authors.forename: Normand
authors.initials: N
authors.lastname: Carrey
authors.forename: Frank P
authors.initials: FP
authors.lastname: MacMaster
authors.forename: Joshua
authors.initials: J
authors.lastname: Fogel
authors.forename: Sandra
authors.initials: S
authors.lastname: Sparkes
authors.forename: Dan
authors.initials: D
authors.lastname: Waschbusch
authors.forename: Sara
authors.initials: S
authors.lastname: Sullivan
authors.forename: Mathias
authors.initials: M
authors.lastname: Schmidt
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002648:Child; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D010865:Pilot Projects; D011522:Protons
chemical_list: D011522:Protons