title: Herpesviruses in brains in Alzheimer's and Parkinson's diseases.
abstract: We evaluated the association of HSV-1, HHV-6, and VZV with Alzheimer's disease (AD) and Parkinson's disease (PD). Brain specimens for viral DNA polymerase chain reaction represented 34 patients with AD, 40 with PD, and 40 controls. One AD patient (2.9%) was positive for HSV-1 DNA, 88.2% for HHV-6 DNA, and 26.5% for VZV DNA; 17.5% of PD patients were HSV-1 DNA-positive and 75% HHV-6-positive, whereas 40% had VZV DNA. Twenty-five percent of the controls were positive for HSV-1 DNA, 87.5% for HHV-6, and 27.5% for VZV. HSV-1, VZV, or HHV-6 DNA in brains was no additional risk factor for AD.
authors.affiliation: Department of Virology, University of Turku, Turku, Finland.
authors.forename: Niina
authors.initials: N
authors.lastname: Hemling
authors.forename: Matias
authors.initials: M
authors.lastname: Röyttä
authors.forename: Juha
authors.initials: J
authors.lastname: Rinne
authors.forename: Paju
authors.initials: P
authors.lastname: Pöllänen
authors.forename: Eeva
authors.initials: E
authors.lastname: Broberg
authors.forename: Virpi
authors.initials: V
authors.lastname: Tapio
authors.forename: Tero
authors.initials: T
authors.lastname: Vahlberg
authors.forename: Veijo
authors.initials: V
authors.lastname: Hukkanen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000821:virology*; D001057:Apolipoproteins E / Q000235:genetics; D001921:Brain / Q000821:virology*; D015342:DNA Probes; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D006564:Herpesviridae; D018259:Herpesvirus 1, Human / Q000235:genetics; D014645:Herpesvirus 3, Human / Q000235:genetics; D015654:Herpesvirus 6, Human / Q000235:genetics; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000821:virology*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D001057:Apolipoproteins E; D015342:DNA Probes; D004279:DNA, Viral