title: Effect of coxsackievirus b3 on ion channel currents in rat ventricular myocytes.
abstract: OBJECTIVE
  To investigate the effects of coxsackievirus B3(CVB3) on ion channel currents in rat ventricular myocytes.
  
  
  METHODS
  Rat hearts were isolated with collagenase to acquire single ventricular myocytes, L-type voltage-dependent calcium channel (VDCC) current (I(Ca)), Na+ current (I(Na)), outward potassium current (I(out)), inwardly rectifying potassium current(I(KI)) were recorded using whole cell patch clamp techniques.
  
  
  RESULTS
  CVB3 infection increased I(Ca) and I(out), while decreased I(KI); but it had no obvious effect on I(Na).
  
  
  CONCLUSIONS
  The effects of CVB3 an I(Ca), I(out), I(KI) may be one of the mechanisms of myocytes damage and the occurrence of abnormal electroactivities induced by CVB3 infection.
authors.affiliation: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital of Shanghai Medical University, Shanghai 200032.
authors.forename: W
authors.initials: W
authors.lastname: Bao
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.forename: C
authors.initials: C
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: Q
authors.initials: Q
authors.lastname: Guo
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D020746:Calcium Channels, L-Type; D002469:Cell Separation; D029822:Enterovirus B, Human / Q000472:pathogenicity; D004769:Enterovirus Infections / Q000503:physiopathology*; D006352:Heart Ventricles / Q000821:virology; D007473:Ion Channels; D032383:Myocytes, Cardiac / Q000502:physiology* / Q000821:virology; D018408:Patch-Clamp Techniques; D024661:Potassium Channels, Inwardly Rectifying; D051381:Rats; D017207:Rats, Sprague-Dawley; D015222:Sodium Channels; D016276:Ventricular Function
chemical_list: D020746:Calcium Channels, L-Type; D007473:Ion Channels; D024661:Potassium Channels, Inwardly Rectifying; D015222:Sodium Channels