title: Parenteral fat emulsions based on olive and soybean oils: a randomized clinical trial in preterm infants.
abstract: OBJECTIVE
  To evaluate in premature infants a new parenteral lipid emulsion based on olive and soybean oils (ratio 4:1), with less polyunsaturated fatty acids (PUFA) and more alpha-tocopherol than standard soybean oil emulsion.
  
  
  METHODS
  Premature infants (gestational age, 28-<37 weeks) were randomized to receive one of the two emulsions within the first 72 hours of life. The triglyceride dose was increased to 2 g/kg/day within 3 days. Plasma phospholipid fatty acids, alpha-tocopherol/lipid ratio, and urinary malondialdehyde (MDA) excretion were determined at baseline and after 7 days.
  
  
  RESULTS
  Of 45 recruited infants, 33 completed the study per protocol (15 soybean oil, 18 olive oil emulsion). At study end, groups did not differ in plasma phospholipid arachidonic acid, total n-6 and n-3 metabolites, but the olive oil group showed higher values of the PUFA intermediates C18:3n-6 (0.19% +/- 0.01% vs. 0.13% +/- 0.02%, P < 0.05) and C20:3n-6 (2.92% +/- 0.12% vs. 2.21% +/- 0.17%, P = 0.005). The plasma alpha-tocopherol/total lipd ratio was higher in the olive oil group (2.45 +/- 0.27 micromol/mmol vs. 1.90 +/- 0.08 micromol/mmol, P = 0.001), whereas urinary MDA excretion did not differ.
  
  
  CONCLUSIONS
  The lower PUFA supply with the olive/soybean oil emulsion appears to enhance linoleic acid conversion. The reduced PUFA content, combined with a higher antioxidant intake in the olive oil group, results in an improved vitamin E status. The olive oil-based emulsion is a valuable alternative for parenteral feeding of preterm infants who are often exposed to oxidative stress, while their antioxidative defense is weak.
authors.affiliation: Dr. von Haunersches Kinderspital, Ludwig-Maximilians-University of Munich, Germany.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Göbel
authors.forename: Berthold
authors.initials: B
authors.lastname: Koletzko
authors.forename: Hans-Josef
authors.initials: HJ
authors.lastname: Böhles
authors.forename: Ilse
authors.initials: I
authors.lastname: Engelsberger
authors.forename: Dominique
authors.initials: D
authors.lastname: Forget
authors.forename: Alexia
authors.initials: A
authors.lastname: Le Brun
authors.forename: Jochen
authors.initials: J
authors.lastname: Peters
authors.forename: Andrea
authors.initials: A
authors.lastname: Zimmermann
mesh_terms: D000975:Antioxidants; D004311:Double-Blind Method; D005217:Fat Emulsions, Intravenous / Q000737:chemistry*; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D000069463:Olive Oil; D010288:Parenteral Nutrition; D010938:Plant Oils / Q000008:administration & dosage* / Q000737:chemistry; D013024:Soybean Oil / Q000008:administration & dosage* / Q000737:chemistry; D024502:alpha-Tocopherol / Q000097:blood
chemical_list: D000975:Antioxidants; D005217:Fat Emulsions, Intravenous; D005231:Fatty Acids, Unsaturated; D000069463:Olive Oil; D010938:Plant Oils; D008315:Malondialdehyde; D013024:Soybean Oil; D024502:alpha-Tocopherol