Gastric function measurements in drug development.
The function of the stomach includes initiation of digestion by exocrine secretions such as acid and pepsin, which are under the control of the endocrine secretion of hormones that also coordinate intestinal motility. The stomach also stores and mechanically disrupts ingested food. Various techniques have been developed to assess gastric physiology, the most important of which is assessment of acid secretion, as well as gastric motility and gastric emptying. The influence of drugs on gastric function and the effect of gastric secretion and mechanical actions on the bioavailability of novel compounds are of critical importance in drug development and hence to clinical pharmacologists. The control of acid secretion is essential in the treatment of peptic ulcer disease as well as gastrooesophageal reflux disease (GORD); pH-metry can be used to determine the necessary dose of an acid suppressant to heal mucosal damage. Disturbed gastric myoelectric activity leading to gastroparesis can cause delayed gastric emptying, often found in patients with diabetes mellitus. Electrogastrography (EGG) may be used to evaluate the influence of prokinetics and other drugs on this condition and aid in determining effective therapy.
Pohle
Thorsten
T
Department of Medicine B, University of Münster, Albert-Schweitzer-Strasse 33, D-48129 Münster, Germany. pohlet@uni-muenster.de
Domschke
Wolfram
W
D004702:Endocrine Glands / Q000502:physiology; D005088:Exocrine Glands / Q000502:physiology; D005746:Gastric Emptying; D005755:Gastrins / Q000097:blood / Q000378:metabolism; D005764:Gastroesophageal Reflux / Q000188:drug therapy / Q000503:physiopathology; D018589:Gastroparesis / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013270:Stomach / Q000502:physiology*
D005755:Gastrins