Duplex and triplex formation of oligodeoxyribonucleotides containing nucleobase-intercalater conjugates.
Novel nucleoside analogues constituting of 2'-deoxyinosine and aromatic rings, which are connected by short linker groups, were synthesized and incorporated into oligodeoxyribonucleotides (ODNs). ODNs containing the nucleoside analogues formed stable duplexes and triplexes with target nucleic acids. The stacking interaction between base residues in the target nucleic acids and the aromatic groups of the nucleoside analogues appears to be a major cause of stabilization.
Kubota
Mio
M
Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University 1-1 Minami-ohsawa, Hachioji, Tokyo, 192-0397, Japan.
Ono
Akira
A
D001483:Base Sequence; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*
D009838:Oligodeoxyribonucleotides