[Effect of nebivolol on the state of pituitary-gonadal system and lipid peroxidation in young and middle aged men with hypertension].
Nebivolol (5-10 mg/day) was given for 12 weeks to 32 patients aged 30-65 years with mild and moderate hypertension. Parameters of pituitary-gonadal system, lipid peroxidation and antioxidant system were determined before nebivolol, and after 1 and 3 months. Normalization of diastolic blood pressure effect was achieved in 87.5% of patients with maximal blood pressure lowering (by 18-20%) after 3 months. Administration of nebivolol was associated with decreases of follicle-stimulating and luteinizing hormones, significant elevation of testosterone concentration (p<0.001), suppression of processes of lipid peroxidation and improvement of activity of antioxidant system. The drug was well tolerated.
Rakhmatullaeva
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D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants; D001578:Benzopyrans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004983:Ethanolamines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005640:Follicle Stimulating Hormone / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D000068577:Nebivolol; D010902:Pituitary Gland / Q000187:drug effects*; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
D000959:Antihypertensive Agents; D000975:Antioxidants; D001578:Benzopyrans; D004983:Ethanolamines; D000068577:Nebivolol; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone