[Association of calcitonin receptor gene polymorphism with bone mineral density in Shanghai women].
OBJECTIVE
To investigate the association of calcitonin receptor (CTR) gene polymorphism with bone mineral density (BMD) in premenopausal and postmenopausal women.


METHODS
CTR genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 184 premenopausal women and 199 postmenopausal women in Shanghai area. BMD at lumbar spine (L2-4) and femoral neck (FN) were measured by dual-energy X-ray absorptiometry (DEXA).


RESULTS
The distribution of CTR genotypes in 383 Shanghai women were CC genotype 83.8%, TC genotype 14.6%, TT genotype 1.6%, respectively. BMD at FN of CC genotype was significantly higher than TC and TT genotypes (P < 0.01) in postmenopausal women. But there was no difference in BMD of different CTR genotypes in premenopausal women. Multiple regression analysis showed that CTR genotypes were associated with FN BMD in postmenopausal women (P < 0.05).


CONCLUSIONS
The polymorphism of CTR gene was associated with BMD in postmenopausal women.
Zhao
Hong-yan
HY
Department of Endocrinology, Ruijin Hospital, Shanghai Second Medical University, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai 200025, China. zhyan725@hotmail.com
Liu
Jian-min
JM
Ning
Guang
G
Zhang
Lian-zhen
LZ
Jiang
Ling
L
Dai
Meng
M
Xu
Man-yin
MY
Chen
Jia-lun
JL
D000328:Adult; D000483:Alleles; D015519:Bone Density; D005260:Female; D005272:Femur Neck; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D017698:Postmenopause; D017697:Premenopause; D018003:Receptors, Calcitonin / Q000235:genetics*
D018003:Receptors, Calcitonin