The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.).
We report that the anti-retroviral and anti-hepadnavirus molecules, adefovir, tenofovir and 9-(2-phosphonomethoxyethyl)-2,6-diaminopurine (PMEDAP), efficiently eradicate the episomal form of Banana streak virus (BSV) from banana plants. Up to 90% of plants regenerated from BSV-infected highly proliferating meristems were virus free following a 6-month treatment period with 10 microg/ml (a non-phytotoxic concentration) of either compounds.
Helliot
B
B
Plant Pathology Unit, Gembloux Agricultural University, 5030 Gembloux, Belgium.
Panis
B
B
Frison
E
E
De Clercq
E
E
Swennen
R
R
Lepoivre
P
P
Neyts
J
J
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D000998:Antiviral Agents / Q000494:pharmacology* / Q000633:toxicity; D019195:Badnavirus / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D028521:Musa / Q000187:drug effects* / Q000821:virology*; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000494:pharmacology / Q000633:toxicity; D010935:Plant Diseases / Q000821:virology*; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology / Q000633:toxicity; D000068698:Tenofovir; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D018894:Reverse Transcriptase Inhibitors; C059499:9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine; C053001:adefovir; D000068698:Tenofovir; D000225:Adenine