title: Synthesis of PNA using a Fmoc/Boc protecting group strategy.
abstract: Syntheses of PNA monomers whose nucleobases are protected with Boc group are described. To overcome the solubility problem of carboxymethyl-guanine derivative, we introduced 2-trimethylsilylethyl group at O6 as a second protecting group.
authors.affiliation: Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kittaka
authors.forename: Yohei
authors.initials: Y
authors.lastname: Takemoto
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takayama
authors.forename: Reiko
authors.initials: R
authors.lastname: Kuroda
mesh_terms: D005449:Fluorenes / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis*
chemical_list: D005449:Fluorenes; D020135:Peptide Nucleic Acids