Changes in oxidative stress and microcirculation by low-density lipoprotein apheresis.
Low-density lipoprotein apheresis (LDLA) leads to an improvement of microcirculation during the very early stages of treatment, and continued treatment may produce antiatherogenic effects in patients with peripheral arterial disease (PAD). Suppression of oxidative stress, improvement of endothelial functions and alteration in the action of vasoactive compounds may occur with the improvement of the rheological property of blood as a result of aggressive removal of atherogenic factors including LDL, possibly resulting in the suppression of development of atherosclerosis. As these effects of LDLA may ameliorate not only PAD but also ischemia in other organs, it is suggested that repeated LDLA prevents the progression of atherosclerotic diseases and probably improves the long-term prognosis of patients with PAD.
Sato
Motoyoshi
M
Department of Dialysis Therapy, Social Insurance Chukyo Hospital, Minami-ku, Nagoya, Japan. ca8m-stu@asahi-net.or.jp
Amano
Izumi
I
D001157:Arterial Occlusive Diseases / Q000175:diagnosis / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology*; D016491:Peripheral Vascular Diseases / Q000175:diagnosis / Q000628:therapy*; D010956:Plasmapheresis / Q000379:methods*; D006435:Renal Dialysis / Q000009:adverse effects; D018570:Risk Assessment; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
D008077:Lipoproteins, LDL