title: The level of total sialic acid, alfa-antitrypsin, ceruloplasmin in the serum of patients with choroidal melanoma.
abstract: Melanoma of the choroid is a fatal disease because of its metastases. The quest is ongoing for more reliable serum markers for detecting and staging ocular melanoma. Total serum sialic acid and acute phase proteins are valuable adjuncts in the management of malignancies, including melanoma. The aim of the paper was to asses the level of total sialic acid (TSA), total sialic acid to total protein (TP) ratio (TSA/TP) and the level of alfa-antitrypsin (AAT) and ceruloplasmin (CER) in patients with choroidal melanoma. The concentrations of TSA, TP, AAT and CER were evaluated in 61 patients with choroidal melanoma and 84 healthy controls. 36 patients had larger tumors and 25 patients had smaller melanomas. 36 patients were treated with brachytherapy. The mean concentration of TSA in all intraocular melanoma patients was 84.86 +/- 19.37 mg/dl and was significantly higher than in control group 53.63 +/- 8.47 mg/dl (p < 0.001). TSA level was significantly higher in patients with large tumors than in those with smaller choroidal melanomas. There were not differences between groups of patients treated with brachy-therapy and those not treated. TSA/TP in melanoma patients was 11.88 +/- 2.97 and it was higher than in control group 7.32 +/- 1.21 (p < 0.001). AAT level was 236.56 +/- 141.53 mg/dl in the group of melanoma patients and in the control group was 226.42 +/- 46.74 mg/dl but the differences were not statistically significant. The concentration of CER in the study group was 28.25 +/- 11.01 mg/dl and in the control group it was 29.56 + 6.33 mg/dl but the differences were not statistically significant. The assessment of TSA in blood serum may be useful in evaluation of patients with choroidal melanoma.
authors.affiliation: 2nd Department of Ophthalmology, Medical University of Lublin.
authors.forename: Anna
authors.initials: A
authors.lastname: Matysik
authors.forename: Jerzy
authors.initials: J
authors.lastname: Toczołowski
authors.forename: Maria
authors.initials: M
authors.lastname: Starzycka
authors.forename: Beata
authors.initials: B
authors.lastname: Jakubowska-Solarska
authors.forename: Janusz
authors.initials: J
authors.lastname: Solski
authors.forename: Bozena
authors.initials: B
authors.lastname: Romanowska-Dixon
authors.forename: Maria
authors.initials: M
authors.lastname: Lewandowska-Furmanik
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002570:Ceruloplasmin / Q000378:metabolism*; D002830:Choroid Neoplasms / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000097:blood / Q000175:diagnosis*; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D011237:Predictive Value of Tests; D012016:Reference Values; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D000515:alpha 1-Antitrypsin; D002570:Ceruloplasmin; D019158:N-Acetylneuraminic Acid