Effects of taurolidine and octreotide on tumor growth and lipid peroxidation after staging-laparoscopy in ductal pancreatic cancer.
Irrigation with taurolidine after laparoscopy decreases tumor growth in colon carcinoma. In pancreatic cancer subcutaneous therapy with octreotide decreases oxidative stress and carcinogenesis as well. However, it is still unclear, whether irrigation with taurolidine or octreotide after laparoscopic pancreatic biopsy reduces tumor growth in pancreatic cancer as well. In 60 Syrian hamsters ductal pancreatic adenocarcinoma was induced by weekly injection of 10mg/kg body weight N-nitrosobis-2-oxopropylamine s.c. for 10 weeks. In week 16 laparoscopic pancreatic biopsy by use of carbon dioxide was performed (gr. 1, n = 20) with subsequent laparoscopic irrigation with taurolidine (gr. 2, n = 20) or octreotide (gr. 3, n = 20). In week 25 hamsters were sacrificed. Our results show that macroscopic visible primary tumors were found in only one animal of the taurolidine group (5.9%), compared to 42.1% in the saline and 62.5% in the octreotide group (P<0.05). Carcinomas were smaller after saline (6+/-23 mm(2)) than after octreotide irrigation (70+/-120 mm(2), P<0.05). In conclusion this study showed that laparoscopic irrigation with taurolidine after pancreatic biopsy inhibited tumor growth in ductal pancreatic adenocarcinoma.
Kilian
M
M
Clinic of General, Visceral, Vascular and Thoracic Surgery, Schumannstrasse 20/21, Charité Campus Mitte, Berlin 10117, Germany.
Mautsch
I
I
Braumann
C
C
Schimke
I
I
Guski
H
H
Jacobi
C A
CA
Wenger
F A
FA
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology; D021441:Carcinoma, Pancreatic Ductal / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D006224:Cricetinae; D010535:Laparoscopy; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008647:Mesocricetus; D015282:Octreotide / Q000008:administration & dosage / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D013654:Taurine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007507:Therapeutic Irrigation; D013829:Thiadiazines / Q000008:administration & dosage / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D013829:Thiadiazines; D017392:Thiobarbituric Acid Reactive Substances; D013654:Taurine; C012566:taurolidine; D015282:Octreotide