[Significance and application of nuclear matrix protein 22 in detecting bladder cancer].
OBJECTIVE
To investigate the significance of nuclear matrix protein 22 (NMP22) in the detection of bladder cancer.


METHODS
The level of NMP22 was measured in the urine of 90 patients (40 patients with bladder cancer and 50 patients with non-bladder cancer) by ELISA and compared with urinic cytology (UC).


RESULTS
The level of NMP22 in bladder cancer group was significantly higher than that of control group, and it was not influenced by hematuria. The sensitivity of NMP22 was high, but the specificity was lower than that of UC.


CONCLUSIONS
NMP22 can be used to screen and follow up bladder cancer with high sensitivity.
Liu
G H
GH
Department of Urology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.
Li
H Z
HZ
D000328:Adult; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000652:urine*; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*
D009687:Nuclear Proteins; C100379:nuclear matrix protein 22