Penetration of cefprozil to middle ear effusion in children with chronic otitis media with effusion.
BACKGROUND
Because of chronic otitis media with effusion (COME) demonstrates pathogenic bacteria, treatment with appropriate antibiotic is reasonable.


OBJECTIVE
We determined the penetration of cefprozil into the middle ear effusion (MEE) in children with COME.


METHODS
25 patients 2-13 years of age with COME were eligible for study. After the single dose of 15 mg/kg patients were assigned to have MEE, and serum samples were obtained during ventilation tube insertion at 0.5, 2, 3, 5, or 6 h after administration of the dose. The concentration of cefprozil was measured using validated high performance liquid chromatography method.


RESULTS
The mean concentrations of cefprozil in the MEE ranged from 0.4 to 4.4 microg/ml. The penetration into MEE was rapid and effective. Cefprozil in the MEE was maintained at a greater level than MIC 90 in S. pneumoniae for at least 6 h after administration of 15 mg/kg.


CONCLUSIONS
Cefprozil penetrated well into the MEE in children with COME.
Jang
Chul Ho
CH
Department of Otolaryngology, Wonkwang Medical School, Iksan 570-711, South Korea. chul@wonkwang.ac.kr
Park
See Young
SY
D000284:Administration, Oral; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004432:Ear, Middle / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D010034:Otitis Media with Effusion / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D000097670:Cefprozil
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000097670:Cefprozil