Usefulness of magnetic motor evoked potentials in the surgical treatment of hemiplegic patients with intractable epilepsy.
Five hemiplegic patients with intractable epilepsy were studied with transcranial magnetic stimulation (TMS) before and after various surgical treatments. These patients had unilateral widespread cerebral lesions acquired at various times, including congenital, infantile and childhood injury. Motor evoked potentials (MEPs) of the abductor pollicis brevis (APB) muscles were simultaneously recorded on both sides following TMS of the motor cortex in the respective hemisphere using a figure-8 or circular coil. In all patients with congenital disease, the abolition of motor function in the affected hemisphere was estimated by magnetic MEPs, and the hemiplegia did not deteriorate after functional hemispherectomy (HS) was performed in two of them. In two patients with acquired disease, HS was not performed because it was shown by magnetic maps that the motor function in the affected hemisphere remained. Furthermore, it was shown by electric MEPs using subdural electrodes that a patient who had had encephalitis in early childhood had a reorganised motor area in the parietal cortex of the affected hemisphere. The present findings indicate that magnetic MEPs are a very useful non-invasive method of assessing whether the motor area in the affected hemisphere can be resected in hemiplegic patients with intractable epilepsy.
Kamida
Tohru
T
Department of Neurosurgery, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita 879-55, Japan.
Baba
Hiroshi
H
Ono
Kenji
K
Yonekura
Masato
M
Fujiki
Minoru
M
Kobayashi
Hidenori
H
D000293:Adolescent; D002540:Cerebral Cortex / Q000503:physiopathology / Q000601:surgery; D004558:Electric Stimulation; D004574:Electromagnetic Fields; D004827:Epilepsy / Q000503:physiopathology / Q000601:surgery*; D019054:Evoked Potentials, Motor; D005260:Female; D006429:Hemiplegia / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology* / Q000601:surgery*; D018482:Muscle, Skeletal; D011300:Preoperative Care / Q000379:methods*