Invitro comparative evaluation of aminoglycosides at a cancer centre.
A comparative study of in vitro activity of amikacin, gentamicin, netilmicin, tobramycin and isepamicin was done. A total of 200 clinical isolates of Gram negative organisms from various clinical sources were tested. E.Coli was the most frequently isolated organism followed by Pseudomonas spp., Klebsiella spp., Proteus spp., Acinetobacter spp. and Enterobacter spp. Of the 5 aminoglycosides tested, isepamicin showed the highest numbers of susceptible isolates followed by amikacin, netilmicin, gentamicin and tobramycin. MIC 90 value of isepamicin was lower as compared to amikacin.
Biswas
S K
SK
Dept. of Microbiology, Tata Memorial Hospital, Parel, Mumbai 400 012, India.
Kelkar
R S
RS
D000150:Acinetobacter / Q000187:drug effects / Q000302:isolation & purification; D000583:Amikacin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004754:Enterobacter / Q000187:drug effects / Q000302:isolation & purification; D005839:Gentamicins / Q000494:pharmacology; D066298:In Vitro Techniques; D007709:Klebsiella / Q000187:drug effects / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D009369:Neoplasms / Q000382:microbiology* / Q000473:pathology; D009428:Netilmicin / Q000494:pharmacology; D011511:Proteus / Q000187:drug effects / Q000302:isolation & purification; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification; D014031:Tobramycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009428:Netilmicin; D000583:Amikacin; C016927:isepamicin; D014031:Tobramycin