title: Ultrastructure of the pineal gland after gamma-irradiation under conditions of inhibition of adrenocortical function.
abstract: Electron microscopy showed that whole-body gamma-irradiation in sublethal doses led to the appearance of injuries in pinealocytes, glial cells, and vessels of the pineal gland in rats. Limitation of the nonspecific effect of gamma-irradiation via inhibition of adrenocortical function with metopirone in physiological doses reduced the radiation-induced ultrastructural damage to the pineal gland.
authors.affiliation: Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. popoutch@mrrc.obninsk.ru
authors.forename: V V
authors.initials: VV
authors.lastname: Popuchiev
authors.forename: N D
authors.initials: ND
authors.lastname: Yakovleva
authors.forename: A G
authors.initials: AG
authors.lastname: Konoplyannikov
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoi
authors.forename: K
authors.initials: K
authors.lastname: Kita
authors.forename: I
authors.initials: I
authors.lastname: Kita
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005720:Gamma Rays; D008297:Male; D008797:Metyrapone / Q000494:pharmacology*; D010870:Pineal Gland / Q000528:radiation effects* / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000963:Antimetabolites; D004791:Enzyme Inhibitors; D008797:Metyrapone