title: An association between the acute phase response and patterns of antigen induced T cell proliferation in juvenile idiopathic arthritis.
abstract: The aim of this research was to determine whether all memory T cells have the same propensity to migrate to the joint in patients with juvenile idiopathic arthritis. Paired synovial fluid and peripheral blood mononuclear cell proliferative responses to a panel of antigens were measured and the results correlated with a detailed set of laboratory and clinical data from 39 patients with juvenile idiopathic arthritis. Two distinct patterns of proliferative response were found in the majority of patients: a diverse pattern, in which synovial fluid responses were greater than peripheral blood responses for all antigens tested; and a restricted pattern, in which peripheral blood responses to some antigens were more vigorous than those in the synovial fluid compartment. The diverse pattern was generally found in patients with a high acute phase response, whereas patients without elevated acute phase proteins were more likely to demonstrate a restricted pattern. We propose that an association between the synovial fluid T cell repertoire and the acute phase response suggests that proinflammatory cytokines may influence recruitment of memory T cells to an inflammatory site, independent of their antigen specificity. Additionally, increased responses to enteric bacteria and the presence of alphaEbeta7 T cells in synovial fluid may reflect accumulation of gut associated T cells in the synovial compartment, even in the absence of an elevated acute phase response. This is the first report of an association between the acute phase response and the T cell population recruited to an inflammatory site.
authors.affiliation: Department of Rheumatology, Division of Immunity and Infection, University of Birmingham, Birmingham, UK.
authors.forename: Antony P B
authors.initials: AP
authors.lastname: Black
authors.forename: Hansha
authors.initials: H
authors.lastname: Bhayani
authors.forename: Clive A J
authors.initials: CA
authors.lastname: Ryder
authors.forename: Mark T
authors.initials: MT
authors.lastname: Pugh
authors.forename: Janet M M
authors.initials: JM
authors.lastname: Gardner-Medwin
authors.forename: Taunton R
authors.initials: TR
authors.lastname: Southwood
mesh_terms: D000210:Acute-Phase Reaction / Q000473:pathology*; D000293:Adolescent; D000942:Antigens, Bacterial / Q000276:immunology*; D001171:Arthritis, Juvenile / Q000097:blood / Q000473:pathology*; D001426:Bacterial Proteins; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016023:Integrins / Q000096:biosynthesis; D008297:Male; D010641:Phenotype; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000096:biosynthesis; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine / Q000096:biosynthesis; D013301:Streptolysins / Q000276:immunology; D013582:Synovial Fluid / Q000166:cytology; D013601:T-Lymphocytes / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D013745:Tetanus Toxoid / Q000276:immunology; D013997:Time Factors
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C515187:CXCR3 protein, human; D016023:Integrins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D054367:Receptors, CXCR3; D019707:Receptors, Chemokine; D013301:Streptolysins; D013745:Tetanus Toxoid; C071777:integrin alpha4beta7; C070709:integrin alphaEbeta7; C025964:streptolysin O