title: Transactivation joins multiple tracks to the ERK/MAPK cascade.
abstract: Many agonists of G-protein-coupled receptors (GPCRs) can stimulate receptor tyrosine kinases and the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway. A 'transactivation' mechanism, which links these events in one signalling chain, inspired many researchers, but inevitably raised new questions. A 'multi-track' model for GPCR signalling to the ERK/MAPK pathway might resolve some of the puzzles in the transactivation field.
authors.affiliation: Institute for Molecular Cell Biology, Jena University Hospital, Drackendorfer Strasse 1, D-07747 JENA, Germany. i5rewe@rz.uni-jena.de
authors.forename: Reinhard
authors.initials: R
authors.lastname: Wetzker
authors.forename: Frank-D
authors.initials: FD
authors.lastname: Böhmer
mesh_terms: D000818:Animals; D004789:Enzyme Activation; D066246:ErbB Receptors / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology*; D008666:Metalloendopeptidases / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D066246:ErbB Receptors; D020928:Mitogen-Activated Protein Kinases; D008666:Metalloendopeptidases; D019204:GTP-Binding Proteins