title: [Expression of annexin II in human esophageal squamous cell carcinoma].
abstract: OBJECTIVE
  To evaluate the expression of annexin II in human esophageal squamous cell carcinoma (ESCC) and its relation with clinicopathological data.
  
  
  METHODS
  The expression of annexin II mRNA and protein in paired cancer tissues and their adjacent quasi-normal tissues were detected by RT-PCR, immunohistochemical method and densitometric scanning. The relation between annexin II expression and the status of tumor differentiation was analyzed.
  
  
  RESULTS
  The expression of annexin II was significantly lower in the tumor tissue than that in its paired normal counterpart both in mRNA and protein level (P < 0.05, P < 0.01). The protein expression of annexin II was significantly lower in moderately and poorly differentiated tumors than those in well differentiated ones (P < 0.05).
  
  
  CONCLUSIONS
  Down-regulation of annexin II in esophageal carcinogenesis may play an important role in squamous cell differentiation.
authors.affiliation: Department of Pathology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Zhang
authors.forename: Hui-ying
authors.initials: HY
authors.lastname: Zhi
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiu-qin
authors.initials: XQ
authors.lastname: Wang
authors.forename: Chuan-nong
authors.initials: CN
authors.lastname: Zhou
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.forename: Yun-tian
authors.initials: YT
authors.lastname: Sun
authors.forename: Zhi-hua
authors.initials: ZH
authors.lastname: Liu
mesh_terms: D017306:Annexin A2 / Q000096:biosynthesis* / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D015536:Down-Regulation; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
chemical_list: D017306:Annexin A2; D012333:RNA, Messenger