title: Bilateral subthalamic nucleus stimulation for the treatment of Parkinson's disease: results of six patients.
abstract: In this study, researchers evaluated the effect of bilateral subthalamic nucleus stimulation on various measures of Parkinson's disease. Assessments were completed before and after surgery in a double-blind fashion under the following six conditions: (a) on medication, (b) off medication, (c) on medication/on stimulation, (d) on medication/off stimulation, (e) off medication/on stimulation, and (f) off medication/off stimulation. On average, improvement was noted in all areas including the Unified Parkinson's Disease Rating Scale, Schwab and England Activities of Daily Living Scale, Modified Hoehn and Yahr Staging, and timed tests: In addition, dyskinesia duration and dyskinesia disability were reduced.
authors.affiliation: Neurosurgical Associates, LTD, Minneapolis, MN, USA. sreriksen@aol.com
authors.forename: Sharon K
authors.initials: SK
authors.lastname: Eriksen
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Tuite
authors.forename: Robert E
authors.initials: RE
authors.lastname: Maxwell
authors.forename: Mary
authors.initials: M
authors.lastname: Sullivan
authors.forename: Walter C
authors.initials: WC
authors.lastname: Low
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Ebner
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D004599:Electric Stimulation Therapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009722:Nurse Practitioners; D010300:Parkinson Disease / Q000534:rehabilitation / Q000601:surgery* / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000601:surgery*; D016896:Treatment Outcome