Primary CD30/Ki-1 positive anaplastic large cell lymphoma of the central nervous system occurring in a patient with a seventeen-year history of essential thrombocythemia.
We present a rare case of central nervous system lymphoma that occurred in a patient who had essential thrombocythemia for 17 years. MRI examinations disclosed multiple ring-enhanced lesions that had shown bilateral spreading in the different period. Pathological examinations confirmed CD30/Ki-1-positive ALK negative anaplastic large cell lymphoma. The possible pathogenic mechanisms of this disease are discussed.
Tajima
Yasutaka
Y
Department of Neurology, Sapporo City General Hospital, N 11, W13, Chu-o-ku, Sapporo, 060-8604, Japan. fwkc2023@mb.infoweb.ne.jp
Miyazaki
Yusei
Y
Higashi
Takuya
T
Kishimoto
Ri-Ichiro
R
Sudoh
Kazumasa
K
Matsumoto
Akihisa
A
Kikuchi
Seiji
S
Tashiro
Kunio
K
D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000378:metabolism; D017728:Lymphoma, Large-Cell, Anaplastic / Q000378:metabolism / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011379:Prognosis; D013920:Thrombocythemia, Essential / Q000150:complications*
D017730:Ki-1 Antigen