Mammary tumors in HER-2/NEU mice are characterized by low content of estrogen receptors-alpha and absence of progesterone receptors.
Transgenic mice carrying erbB2(HER-2)neu gene are characterized by high incidence of mammary adenocarcinoma. The content of estrogen receptor was no more than 10 fmol/mg protein in 8 of 14 studied tumors, while the content of progesterone receptors was even lower in all 14 studied tumors. Based on these data, we distinguish two subtypes of HER-2/neu-adenocarcinomas in mice: ER+,PR- and ER-,PR-, which can be used for the development of new approaches to the treatment of receptor-negative mammary gland tumors.
Bershtein
L M
LM
N. N. Petrov Institute of Oncology, Ministry of Health of Russian Federation, St. Petersburg.
Alimova
I N
IN
Tsyrlina
E V
EV
Anisimov
V N
VN
D000230:Adenocarcinoma / Q000378:metabolism*; D000818:Animals; D047628:Estrogen Receptor alpha; D005260:Female; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*
D047628:Estrogen Receptor alpha; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone