Risperidone, but not olanzapine, decreases bone mineral density in female premenopausal schizophrenia patients.
BACKGROUND
The hyperprolactinemia induced by conventional antipsychotics often leads to osteoporosis. The commonly used atypical antipsychotics risperidone and olanzapine vary in their hyperprolactinemic properties. Therefore, we compared hormone profiles and bone properties in female premenopausal schizophrenia patients treated with either risperidone or olanzapine.


METHODS
In a cross-sectional study, consecutive premenopausal, female, DSM-IV schizophrenia patients who were treated with either risperidone (N = 12) or olanzapine (N = 14) for at least 2 years were included. Dual energy X-ray absorptiometry evaluated bone mineral density, and multisite quantitative ultrasound measured bone speed of sound. In addition, profiles of urinary excretion of deoxypyridinoline and circulating levels of hormones and lipids were assessed.


RESULTS
Serum prolactin levels were higher in the risperidone-treated group as compared with the olanzapine subjects (123 +/- 144 and 25.9 +/- 25.7, p <.05). Whereas bone mineral density was similar in the treatment groups, bone speed of sound was lower in the risperidone group as compared with the olanzapine-treated group. Expressed as age-adjusted Z score, bone speed of sound at the radius was -0.31 and 0.58, respectively, p <.05, and at the phalanx, -1.41 and 0.04, respectively, p <.05. The bone speed of sound in the risperidone-treated patients inversely correlated with urinary deoxypyridinoline excretion (r = 0.73, p <.05).


CONCLUSIONS
Risperidone treatment, as opposed to olanzapine, for female premenopausal schizophrenia results in hyperprolactinemia and clinically relevant decrease in bone mineral density. The calculated relative risk for fragility fracture of women treated with risperidone as compared to those treated with olanzapine is 1.78 when bone speed of sound was measured at the phalanx and 1.23 when measured at the radius.
Becker
Daniel
D
Ness Ziona Mental Health Center, Ness Ziona, Israel.
Liver
Olga
O
Mester
Roberto
R
Rapoport
Micha
M
Weizman
Abraham
A
Weiss
Mordechai
M
D015502:Absorptiometry, Photon / Q000379:methods; D000293:Adolescent; D000328:Adult; D001569:Benzodiazepines; D015519:Bone Density / Q000187:drug effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D000077152:Olanzapine; D010024:Osteoporosis / Q000139:chemically induced* / Q000175:diagnosis; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D017697:Premenopause; D011388:Prolactin / Q000097:blood / Q000187:drug effects; D018967:Risperidone / Q000009:adverse effects*; D012559:Schizophrenia / Q000188:drug therapy*; D012702:Serotonin Antagonists / Q000009:adverse effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
D001569:Benzodiazepines; D000077152:Olanzapine; D010890:Pirenzepine; D011388:Prolactin; D018967:Risperidone; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors