Disk diffusion-based methods for determining Candida parapsilosis susceptibility to anidulafungin.
Zone diameters for anidulafungin by disk diffusion for 139 isolates of C. parapsilosis were compared with MICs by NCCLS M27-A2 broth microdilution. The comparison was poor unless the disks were prepared by dissolving anidulafungin in 1% dimethyl sulfoxide plus 0.1% Tween 80 and testing on Mueller-Hinton agar flooded with glucose and methylene blue.
Odabasi
Zekaver
Z
Division of Infectious Diseases, University of Texas-Houston Medical School, Houston, Texas 77030, USA. zekaver.odabasi@uth.tmc.edu
Paetznick
Victor
V
Goldstein
Beth P
BP
Rex
John H
JH
Ostrosky-Zeichner
Luis
L
D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D003470:Culture Media; D004058:Diffusion; D054714:Echinocandins; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000494:pharmacology*; D012997:Solvents
D000935:Antifungal Agents; D003470:Culture Media; D054714:Echinocandins; D010456:Peptides, Cyclic; D012997:Solvents; D000077612:Anidulafungin