[Role of neuraminidase in pathogenesis of influenza].
The influenza neuraminidase (NA) possesses, both in vivo and in vitro, the anticoagulant and fibrinolytic activity. A computerized comparative analysis of the influenza NA viruses, type A, showed nine regions of amino-acid sequences compatible with the tissue activator of human plasminogen. The mentioned regions are highly conservative for each NA subtype irrespective of a source or a year, when an influenza strain was isolated. The role of NA in pathogenesis of influenza infection is under consideration.
Zhilinskaia
I N
IN
Liapina
L A
LA
Reshetnikova
O Iu
OIu
Kisleev
O I
OI
D000595:Amino Acid Sequence; D005342:Fibrinolysis; D006801:Humans; D009980:Influenza A virus / Q000201:enzymology / Q000472:pathogenicity*; D007251:Influenza, Human / Q000201:enzymology*; D008969:Molecular Sequence Data; D009439:Neuraminidase / Q000378:metabolism*
D009439:Neuraminidase