Response to systemic HIV viral load suppression correlates with psychomotor speed performance.
The authors evaluated the association of a virologic response to highly active antiretroviral therapy, or a subsequent rebound, with performance on two measures of psychomotor speed in HIV-positive subjects. Virologic suppression was associated with improved performance on measures of psychomotor speed, and virologic rebound was associated with psychomotor speed performance decline. Changes in plasma HIV viral load in HIV-positive individuals with cognitive slowing correlate with performance on tests of psychomotor speed.
Sacktor
N
N
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. sacktor@jhmi.edu
Skolasky
R L
RL
Tarwater
P M
PM
McArthur
J C
JC
Selnes
O A
OA
Becker
J
J
Cohen
B
B
Visscher
B
B
Miller
E N
EN
D015526:AIDS Dementia Complex / Q000188:drug therapy / Q000523:psychology / Q000821:virology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D018450:Disease Progression; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011597:Psychomotor Performance; D019562:Viral Load; D014766:Viremia / Q000188:drug therapy* / Q000523:psychology