title: Biological variation for N-terminal pro- and B-type natriuretic peptides and implications for therapeutic monitoring of patients with congestive heart failure.
abstract: Given the limitations of low enrollments, this study suggests that a change of 130% for B-type natiuretic peptide (BNP) and 90% for N-terminal (NT)-proBNP are necessary before results of serially collected data can be considered statistically different. This study also shows that there are important differences in the performance of BNP versus NT-proBNP in monitoring patients with congestive heart failure that need to be further explored.
authors.affiliation: Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, Connecticut 06102, USA. awu@harthosp.org
authors.forename: Alan H B
authors.initials: AH
authors.lastname: Wu
authors.forename: Andrew
authors.initials: A
authors.lastname: Smith
authors.forename: Stacey
authors.initials: S
authors.lastname: Wieczorek
authors.forename: Jeffrey F
authors.initials: JF
authors.lastname: Mather
authors.forename: Bret
authors.initials: B
authors.lastname: Duncan
authors.forename: C Michael
authors.initials: CM
authors.lastname: White
authors.forename: Carol
authors.initials: C
authors.lastname: McGill
authors.forename: Deb
authors.initials: D
authors.lastname: Katten
authors.forename: Gary
authors.initials: G
authors.lastname: Heller
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016002:Discriminant Analysis; D016903:Drug Monitoring / Q000379:methods* / Q000592:standards; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007118:Immunoassay / Q000379:methods / Q000592:standards; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain; D015588:Observer Variation; D010865:Pilot Projects; D019095:Point-of-Care Systems / Q000592:standards; D011498:Protein Precursors / Q000097:blood*; D011863:Radioimmunoassay / Q000379:methods / Q000592:standards; D012016:Reference Values; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D015415:Biomarkers; C099254:N-terminal proatrial natriuretic peptide; D011498:Protein Precursors; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor