title: Inflammatory aortic aneurysm is associated with increased incidence of autoimmune disease.
abstract: OBJECTIVE
  It has been suggested that certain genetic risk factors indicative of an autoimmune mechanism can be identified in patients with inflammatory aortic aneurysm (IAA). We therefore investigated whether there was a higher incidence of autoimmune diseases in patients with IAA. Further, we explored risk factors, need for in-hospital resources, and early results of treatment, in a case-control study in a university hospital setting. Material and methods From 1983 to 1994, 520 patients were operated because of abdominal aortic aneurysm (AAA). Thirty-one patients had IAA. Control subjects were matched for aneurysm rupture, emergency or elective hospital admission, and date of operation. Two noninflammatory AAA were included for every IAA.
  
  
  RESULTS
  Of the 31 patients with IAA, 6 patients (19%) had autoimmune disease, compared with none of the control subjects (P =.0017). Two patients had rheumatoid arthritis, 2 patients had systemic lupus erythematosus, 1 had giant cell arteritis, and 1 patient had an undifferentiated seronegative polyarthritis diagnosed as rheumatoid arthritis. Nineteen patients (61%) with IAA had involvement of the duodenum, and 8 patients (26%) had hydronephrosis with ureteral involvement. Operating time was longer in the IAA group, which also had a higher need for blood transfusion. Hospital stay, intensive care unit stay, and 30-day mortality were similar in the two groups.
  
  
  CONCLUSIONS
  Except for longer operating time and more need for blood transfusions in the IAA group, use of hospital resources was similar after operations to treat IAA or noninflammatory AAA. The study findings indicate an association between IAA and autoimmune disease. This is in accordance with other reports that showed a genetic risk determinant mapped to the human leukocyte antigen (HLA) molecule in these patients. Further research is necessary to explore whether IAA might be a separate entity with a role of antigen binding in the origin of the disease.
authors.affiliation: Department of Surgery, University Hospital of Trondheim, Trondheim, Norway.
authors.forename: E S
authors.initials: ES
authors.lastname: Haug
authors.forename: J F
authors.initials: JF
authors.lastname: Skomsvoll
authors.forename: G
authors.initials: G
authors.lastname: Jacobsen
authors.forename: T B
authors.initials: TB
authors.lastname: Halvorsen
authors.forename: O D
authors.initials: OD
authors.lastname: Saether
authors.forename: H O
authors.initials: HO
authors.lastname: Myhre
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000785:Aneurysm, Infected / Q000453:epidemiology* / Q000473:pathology* / Q000601:surgery; D017544:Aortic Aneurysm, Abdominal / Q000453:epidemiology* / Q000473:pathology* / Q000601:surgery; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000453:epidemiology*; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D011336:Probability; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D014656:Vascular Surgical Procedures