title: From model complexes to metalloprotein inhibition: a synergistic approach to structure-based drug discovery.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.
authors.forename: David T
authors.initials: DT
authors.lastname: Puerta
authors.forename: Julie R
authors.initials: JR
authors.lastname: Schames
authors.forename: Richard H
authors.initials: RH
authors.lastname: Henchman
authors.forename: J Andrew
authors.initials: JA
authors.lastname: McCammon
authors.forename: Seth M
authors.initials: SM
authors.lastname: Cohen
mesh_terms: D001665:Binding Sites; D018360:Crystallography, X-Ray; D015195:Drug Design; D007202:Indicators and Reagents; D019278:Matrix Metalloproteinase 3 / Q000737:chemistry; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000737:chemistry; D008670:Metals / Q000737:chemistry; D008958:Models, Molecular; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D007202:Indicators and Reagents; D061965:Matrix Metalloproteinase Inhibitors; D008670:Metals; D011480:Protease Inhibitors; D020782:Matrix Metalloproteinases; D019278:Matrix Metalloproteinase 3