Gender differences in oxidative stress in spinal cord of rats submitted to repeated restraint stress.
Behavioral and neurochemical gender-specific effects have been observed following repeated stress. The aim of this study is to verify the effects of repeated restraint stress on free radical production (evaluated by DCF test), lipoperoxidation (evaluated by TBARS levels), and total antioxidant reactivity (TAR) in the spinal cord of male and female rats. Results demonstrate no effect on lipoperoxidation; chronic stress decreased TAR both in male and female spinal cord. In addition, gender differences were observed both in TAR and in the production of free radicals, both being increased in females. These results may be relevant to the gender-specific differences observed after exposure to repeated stress.
Tabajara
Angela Sampaio
AS
Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, UFRGS. Porto Alegre, Brazil.
Fontella
Fernanda Urruth
FU
Torres
Iraci Lucena da Silva
IL
Dalmaz
Carla
C
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D012149:Restraint, Physical; D012737:Sex Factors; D013116:Spinal Cord / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism*
D000975:Antioxidants; D005609:Free Radicals; D017382:Reactive Oxygen Species