Targeted toxins in pain.
Although only recently applied to the study of nociception, 'molecular neurosurgery', producing highly selective neural lesions using targeted cytotoxins, has proven a valuable tool for analysis of nociceptive systems and promises to yield much more information on the role of specific types of neurons in pain perception and possibly new pain therapies. Neuropeptide-toxin conjugates, particularly, substance P-saporin, have proven useful research tools and may find clinical applications. Targeting non-lethal moieties (enzymes, genes, viruses) also may prove useful for research and therapeutic purposes.
Wiley
Ronald G
RG
Department of Neurology, Vanderbilt University, Nashville, TN 37212, USA. ronald.g.wiley@vanderbilt.edu
Lappi
Douglas A
DA
D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D000922:Immunotoxins / Q000008:administration & dosage / Q000627:therapeutic use*; D009479:Neuropeptides / Q000008:administration & dosage / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy*; D012270:Ribosomes / Q000187:drug effects
D000922:Immunotoxins; D009479:Neuropeptides