title: Hereditary ovarian cancer in Poland.
abstract: There is increasing evidence that hereditary factors play a greater role in ovarian cancer than in any of the other common cancers of adulthood. This is attributable, to a large extent, to a high frequency of mutations in the BRCA1 or BRCA2 genes. In Poland, 3 common founder mutations in BRCA1 account for the majority of families with identified BRCA mutations. Our study was conducted in order to estimate the prevalence of any of 3 founder BRCA1 mutations (5382insC, C61G and 4153delA) in 364 unselected women with ovarian cancer, and among 177 women with ovarian cancer and a family history of breast or ovarian cancer. A mutation was identified in 49 out of 364 unselected women with ovarian cancer (13.5%) and in 58 of 177 women with familial ovarian cancer (32.8%). The majority of women with ovarian cancer and a BRCA1 mutation have no family history of breast or ovarian cancer. The high frequency of BRCA1 mutations in Polish women with ovarian cancer supports the recommendation that all Polish women with ovarian cancer should be offered testing for genetic susceptibility, and that counseling services be made available to them and to their relatives. It is important that mutation surveys be conducted in other countries prior to the introduction of national genetic screening programs.
authors.affiliation: Department of Surgical Gynecology and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland. janusz@sz.home.pl
authors.forename: Janusz
authors.initials: J
authors.lastname: Menkiszak
authors.forename: Jacek
authors.initials: J
authors.lastname: Gronwald
authors.forename: Bohdan
authors.initials: B
authors.lastname: Górski
authors.forename: Anna
authors.initials: A
authors.lastname: Jakubowska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Huzarski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Byrski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Foszczyńska-Kłoda
authors.forename: Olga
authors.initials: O
authors.lastname: Haus
authors.forename: Hanna
authors.initials: H
authors.lastname: Janiszewska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Perkowska
authors.forename: Izabela
authors.initials: I
authors.lastname: Brozek
authors.forename: Ewa
authors.initials: E
authors.lastname: Grzybowska
authors.forename: Helena
authors.initials: H
authors.lastname: Zientek
authors.forename: Stanisław
authors.initials: S
authors.lastname: Góźdź
authors.forename: Beata
authors.initials: B
authors.lastname: Kozak-Klonowska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Urbański
authors.forename: Roman
authors.initials: R
authors.lastname: Miturski
authors.forename: Jerzy
authors.initials: J
authors.lastname: Kowalczyk
authors.forename: Anna
authors.initials: A
authors.lastname: Pluzańska
authors.forename: Stanisław
authors.initials: S
authors.lastname: Niepsuj
authors.forename: Jan
authors.initials: J
authors.lastname: Koc
authors.forename: Marek
authors.initials: M
authors.lastname: Szwiec
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Drosik
authors.forename: Andrzej
authors.initials: A
authors.lastname: Mackiewicz
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Lamperska
authors.forename: Elwira
authors.initials: E
authors.lastname: Strózyk
authors.forename: Dariusz
authors.initials: D
authors.lastname: Godlewski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Stawicka
authors.forename: Bernard
authors.initials: B
authors.lastname: Waśko
authors.forename: Marek
authors.initials: M
authors.lastname: Bebenek
authors.forename: Andrzej
authors.initials: A
authors.lastname: Rozmiarek
authors.forename: Izabella
authors.initials: I
authors.lastname: Rzepka-Górska
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
authors.forename: Jan
authors.initials: J
authors.lastname: Lubiński
mesh_terms: D024682:BRCA2 Protein / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011044:Poland / Q000453:epidemiology; D015995:Prevalence
chemical_list: D024682:BRCA2 Protein; D009363:Neoplasm Proteins