[Research into simultaneous spectrophotometric determination of components in cough syrup by principal component regression method].
Principal component regression (PCR) method is used to analyse five components: acetaminophen, p-aminophenol, caffeine, chlorphenamine maleate and guaifenesin. The basic principle and the analytical step of the approach are described in detail. The computer program of LHG is based on VB language. The experimental result shows that the PCR method has no systematical error as compared to classical method. The experimental result shows that the average recovery of each component is all in the range from 96.43% to 107.14%. Each component obtains satisfactory result without any pre-separation. The approach is simple, rapid and suitable for the computer-aid analysis.
Zhang
Li-qing
LQ
Department of Biological and Chemistry Engineering, Zhejiang University of Science and Technology, Hangzhou 310012, China.
Wu
Xiao-hua
XH
Tang
Xi
X
Zhu
Xian-liang
XL
Su
Wen-ting
WT
D000082:Acetaminophen / Q000032:analysis*; D000627:Aminophenols / Q000032:analysis*; D018712:Analgesics, Non-Narcotic / Q000032:analysis*; D002110:Caffeine / Q000032:analysis*; D002744:Chlorpheniramine / Q000032:analysis; D004338:Drug Combinations; D005100:Expectorants / Q000032:analysis; D006140:Guaifenesin / Q000032:analysis; D006634:Histamine H1 Antagonists / Q000032:analysis; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D000627:Aminophenols; D018712:Analgesics, Non-Narcotic; D004338:Drug Combinations; D005100:Expectorants; D006634:Histamine H1 Antagonists; D000082:Acetaminophen; D002110:Caffeine; D002744:Chlorpheniramine; D006140:Guaifenesin; C026729:4-aminophenol