[Antibiotic susceptibility of Neisseria gonorrhoeae epidemic strains in Changsha].
OBJECTIVE
To evaluate the antibiotic susceptibility of Neisseria gonorrhoeae epidemic strains in Changsha and to provide a reference for the prevention and treatment of gonorrhea.


METHODS
beta-Lactamase was determined by a modified iodometric method and the susceptibility to 9 antibiotic agents was tested by the disc diffusion method in 86 isolates.


RESULTS
Plasmid-mediated penicillinase-producing Neisseria gonorrhoeae and plasmid-mediated tetracycline-resistant Neisseria gonorrhoeae were 40.69% and 23.26%, respectively. Of all the 9 antibiotic agents, tetracycline, cefmetazole, penicillin, ciprofloxacin, and ofloxacin had a higher resistance and the percentages of resistance were 45.35%, 50.00%, 62.79%, 77.91%, and 87.21%, respectively. On the other hand, cefuroxime, ceftriaxone, cefepime, and spectinomycin had a higher susceptibility and the percentages of susceptibility were 77.91%, 80.23%, 86.05%, and 98.84%, respectively.


CONCLUSIONS
Penicillin, tetracycline and fluoroquinolone can not be used as routine agents to cure gonorrhea; and spectinomycin can be used as primary medicine to cure gonorrhea in Changsha, but clinical doctors need to pay more attention to it because resistant strains have come into existence.
Zou
Ming-xiang
MX
Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha 410008, China.
Xia
Zhong-di
ZD
Liang
Xiang-hui
XH
D015311:Cefmetazole / Q000494:pharmacology; D002681:China; D002939:Ciprofloxacin / Q000494:pharmacology; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D010403:Penicillin Resistance; D000198:Spectinomycin / Q000494:pharmacology*; D013753:Tetracycline Resistance; D018440:beta-Lactam Resistance; D001618:beta-Lactamases
D024841:Fluoroquinolones; D015311:Cefmetazole; D002939:Ciprofloxacin; D000198:Spectinomycin; D001618:beta-Lactamases