title: [Nasal remodeling in patient with perennial allergic rhinitis].
abstract: BACKGROUND
  Remodeling is considered a new or different reconstruction of tissues. The airway remodeling is a consequence of changes induced by endothelial cells and extra-cellular matrix as a result of chronic inflammation.
  
  
  OBJECTIVE
  To show histological changes into mucosa in patients with perennial allergic rhinitis.
  
  
  METHODS
  We studied 26 patients with perennial allergic rhinitis, with evolution of 3 to 6 years, between 20 to 40 years old, without medical or immunological treatment. A turbinate biopsy was taken in all of them.
  
  
  RESULTS
  We found enlargement of the basal membrane in 92.3%, subepithelial fibrosis in 92.4%, neutrophils in 100% of the cases, eosinophils in 100%, lymphocytes in 100%, edema in 46.2%, fragmented reticular fibers in 19.2%, and vascular dilatation in 11.1%.
  
  
  CONCLUSIONS
  These results suggest nasal remodeling in patients with allergic rhinitis, although more structural studies about this pathology are necessary.
authors.affiliation: Servicio de alergia e inmunología clínica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, col. Doctores, CP 06720, México, DF.
authors.forename: Patricia
authors.initials: P
authors.lastname: Montero Mora
authors.forename: Enrique
authors.initials: E
authors.lastname: Blanco
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Matta Campos
authors.forename: Alicia
authors.initials: A
authors.lastname: González Espinosa
authors.forename: Guillermo
authors.initials: G
authors.lastname: Guidos Fogelbach
authors.forename: Olga Adriana
authors.initials: OA
authors.lastname: Tinajeros Castañeda
mesh_terms: D000328:Adult; D001706:Biopsy; D006801:Humans; D009297:Nasal Mucosa / Q000473:pathology*; D012221:Rhinitis, Allergic, Perennial / Q000473:pathology*