Unnatural RNA display libraries.
Combinatorial peptide and protein libraries have now been developed to accommodate unnatural amino acids in a genetically encoded format via in vitro nonsense and sense suppression. General translation features and specific regioselective and stereoselective properties of the ribosome endow these libraries with a broad chemical diversity. Alternatively, amino acid residues can be chemically derivatized post-translationally to add preferred functionality to the encoded peptide. All of these efforts are advancing combinatorial peptide and protein libraries for enhanced ligands against biological targets of interest.
Frankel
Adam
A
Division of Chemistry & Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Li
Shuwei
S
Starck
Shelley R
SR
Roberts
Richard W
RW
D000818:Animals; D015723:Gene Library; D006801:Humans; D019151:Peptide Library; D010455:Peptides / Q000235:genetics; D012313:RNA; D012270:Ribosomes / Q000737:chemistry
D019151:Peptide Library; D010455:Peptides; D012313:RNA