Irp9, encoded by the high-pathogenicity island of Yersinia enterocolitica, is able to convert chorismate into salicylate, the precursor of the siderophore yersiniabactin.
The Irp9 protein of Yersinia enterocolitica participates in the synthesis of salicylate, the precursor of the siderophore yersiniabactin. In Pseudomonas species, salicylate synthesis is mediated by two enzymes: isochorismate synthase and isochorismate pyruvate-lyase. Both enzymes are required for complementation of a Yersinia irp9 mutant. However, irp9 is not able to complement Escherichia coli entC for the production of enterobactin, which requires isochorismate as a precursor. These results suggest that Irp9 directly converts chorismate into salicylate.
Pelludat
Cosima
C
Institut für Mikrobiologie, D-BIOL, ETHZ, 8092 Zürich, Switzerland.
Brem
Daniela
D
Heesemann
Jürgen
J
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002827:Chorismic Acid / Q000378:metabolism*; D053138:Cyclohexenes; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D005816:Genetic Complementation Test; D062385:Hydroxybenzoates / Q000494:pharmacology; D019751:Intramolecular Transferases / Q000235:genetics / Q000378:metabolism; D008190:Lyases / Q000235:genetics / Q000378:metabolism*; D005810:Multigene Family; D009154:Mutation; D007652:Oxo-Acid-Lyases / Q000235:genetics / Q000378:metabolism; D010636:Phenols; D011498:Protein Precursors / Q000378:metabolism; D011551:Pseudomonas fluorescens / Q000235:genetics; D012459:Salicylates / Q000378:metabolism*; D017262:Siderophores / Q000378:metabolism*; D013844:Thiazoles; D014774:Virulence / Q000235:genetics; D015008:Yersinia enterocolitica / Q000187:drug effects / Q000378:metabolism* / Q000472:pathogenicity
D001426:Bacterial Proteins; D053138:Cyclohexenes; D062385:Hydroxybenzoates; D010636:Phenols; D011498:Protein Precursors; D012459:Salicylates; D017262:Siderophores; D013844:Thiazoles; C104398:yersiniabactin; C015076:chrome azurol S; C052985:isochorismic acid; D008190:Lyases; C022620:salicylate synthetase; D007652:Oxo-Acid-Lyases; C075960:chorismate pyruvate lyase; D019751:Intramolecular Transferases; C058486:isochorismate synthase; D002827:Chorismic Acid