title: Diagnosis and management of anaphylaxis.
abstract: Anaphylaxis is a severe systemic allergic reaction that is potentially fatal. It requires prompt recognition and immediate management. Anaphylaxis has a rapid onset with multiple organ-system involvement and is mostly caused by specific antigens in sensitized individuals. Reactions typically follow a uniphasic course, however, 20% will be biphasic in nature. The second phase usually occurs after an asymptomatic period of 1-8 hours, but there may be a 24-hour delay. Protracted anaphylaxis may persist beyond 24 hours. Concurrent beta-blocker therapy may adversely affect the response to management. Epinephrine is the treatment of choice and should be administered immediately. Secondary measures include circulatory support, H(1) and H(2) antagonists, corticosteroids and, occasionally, bronchodilators. Post-treatment observation of these patients is necessary, and they should remain within ready access of emergency care for the following 48 hours.
authors.affiliation: Department of Medicine, Queen's University, and the Division of Allergy and Immunology, Kingston General Hospital, Kingston, ON. ellisa@kgh.kari.net
authors.forename: Anne K
authors.initials: AK
authors.lastname: Ellis
authors.forename: James H
authors.initials: JH
authors.lastname: Day
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects
chemical_list: D018926:Anti-Allergic Agents