[Assay for paracetamol by derivative spectrophotometry in compound amantadine tablets].
Compound amantadine tablets is a new drug for virus-common cold. It was consisted of paracetamol, amantadine hydrochloride and caffeine etc. Because of the disturbing of the caffeine, the paracetamol can not be determined by UV directly. So the paracetamol in compound amantadine tablets was determined by derivative spectrophotometry. This method is simple and rapid, no distillation and no separation, with average recovery of 100.0%, and RSD of 0.36%.
Zhang
Jin
J
Chongqing Institute for Drug Control, Chongqing 400015, China.
Zhang
Xiao-song
XS
D000082:Acetaminophen / Q000032:analysis*; D000547:Amantadine / Q000032:analysis*; D000998:Antiviral Agents / Q000737:chemistry*; D002110:Caffeine / Q000032:analysis*; D004338:Drug Combinations; D004364:Pharmaceutical Preparations; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013607:Tablets
D000998:Antiviral Agents; D004338:Drug Combinations; D004364:Pharmaceutical Preparations; D013607:Tablets; D000082:Acetaminophen; D002110:Caffeine; D000547:Amantadine