Identification of 46 novel SNPs in the 130-kb region containing a myocardial infarction susceptibility gene on chromosomal band 6p21.
We identified a total of 187 single-nucleotide polymorphisms (SNPs) at 11 gene loci in the 130-kb region on chromosome 6p21 containing a gene strongly associated with myocardial infarction (MI). By comparing our data with SNPs deposited in the dbSNP database at the National Center for Biotechnology Information, 46 of these SNPs (24.6%) were considered to be novel: four were identified in the P5-1 locus, 14 in the MICB locus, nine in the BAT1 locus, one in the ATP6V1G2 locus, six in the NFKBIL1 locus, one in the LTA locus, one in the TNF locus, five in the LST1 locus, four in the LY117a locus, and one in the AIF-1 locus. The SNP map presented here should provide as useful resource not only for examining the relationships between genotypes and susceptibility to the MI phenotype, but also for scanning of complex diseases mapped to this local segment on chromosome 6.
Iida
Aritoshi
A
Laboratory for Genotyping, RIKEN SNP Research Center, Kanagawa, Japan.
Ozaki
Kouichi
K
Laboratory for Cardiovascular Diseases, RIKEN SNP Research Center, Tokyo, Japan.
Ohnishi
Yozo
Y
Laboratory for Cardiovascular Diseases, RIKEN SNP Research Center, Tokyo, Japan.
Tanaka
Toshihiro
T
Laboratory for Cardiovascular Diseases, RIKEN SNP Research Center, Tokyo, Japan.
Nakamura
Yusuke
Y
Laboratory for Genotyping, RIKEN SNP Research Center, Kanagawa, Japan. yusuke@ims.u-tokyo.ac.jp.|Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. yusuke@ims.u-tokyo.ac.jp.
D020413:3' Untranslated Regions / Q000235:genetics; D020121:5' Untranslated Regions / Q000235:genetics; D016022:Case-Control Studies; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D004198:Disease Susceptibility; D005091:Exons; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007438:Introns; D009203:Myocardial Infarction / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D005819:Genetic Markers