title: Color M-mode and Doppler tissue evaluation of diastolic function in children: simultaneous correlation with invasive indices.
abstract: OBJECTIVE
  The purpose of this study was to explore the validity of diastolic indices derived from color M-mode Doppler and Doppler tissue imaging in a heterogeneous group of pediatric patients by comparing them with simultaneously obtained invasive indices of diastolic function.
  
  
  METHODS
  A total of 20 children undergoing left heart catheterization had echocardiographic images recorded simultaneously with high-fidelity left ventricular (LV) pressure tracings. Transmitral Doppler, pulmonary vein Doppler, Doppler tissue imaging, and color M-mode Doppler flow propagation velocity were recorded. LV peak negative dP/dt, the time constant of isovolumic relaxation, and LV end-diastolic pressure were compared with the echocardiographic indices.
  
  
  RESULTS
  The ratio of peak E-wave mitral velocity/propagation velocity correlated significantly with LV end-diastolic pressure (r = 0.71; P <.001). Propagation velocity correlated with the time constant of isovolumic relaxation (r = -0.56; P =.01) and peak negative dP/dt (r = 0.50; P <.03). Septal mitral annular myocardial velocity correlated significantly with the time constant of isovolumic relaxation (r = -0.58, P =.01).
  
  
  CONCLUSIONS
  The newer diastolic indices derived from color M-mode Doppler and Doppler tissue imaging appear to be a helpful adjunct in the noninvasive assessment of diastolic function in children.
authors.affiliation: Cincinnati Children's Hospital Medical Center, OH 45229-3039, USA. William.Border@chmcc.org
authors.forename: William L
authors.initials: WL
authors.lastname: Border
authors.forename: Erik C
authors.initials: EC
authors.lastname: Michelfelder
authors.forename: Betty J
authors.initials: BJ
authors.lastname: Glascock
authors.forename: Sandra A
authors.initials: SA
authors.lastname: Witt
authors.forename: Robert L
authors.initials: RL
authors.lastname: Spicer
authors.forename: Robert H
authors.initials: RH
authors.lastname: Beekman
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Kimball
mesh_terms: D000293:Adolescent; D000328:Adult; D001021:Aortic Valve / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000503:physiopathology; D006328:Cardiac Catheterization; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis / Q000503:physiopathology; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D003971:Diastole / Q000502:physiology; D004452:Echocardiography; D018618:Echocardiography, Doppler, Color; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006325:Heart Atria / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000503:physiopathology; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006352:Heart Ventricles / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007229:Infant Welfare; D007231:Infant, Newborn; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000175:diagnosis / Q000503:physiopathology; D015588:Observer Variation; D009820:Ohio; D011667:Pulmonary Veins / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000503:physiopathology; D015203:Reproducibility of Results; D013223:Statistics as Topic; D013318:Stroke Volume / Q000502:physiology*