DNA mismatch repair proteins: potential guardians against genomic instability and tumorigenesis induced by ultraviolet photoproducts.
In addition to their established role in repairing post-replicative DNA errors, DNA mismatch repair proteins contribute to cell cycle arrest and apoptosis in response to a wide range of exogenous DNA damage (e.g., alkylation-induced lesions). The role of DNA mismatch repair in response to ultraviolet-induced DNA damage has been historically controversial. Recent data, however, suggest that DNA mismatch repair proteins probably do not contribute to the removal of ultraviolet-induced DNA damage, but may be important in suppressing mutagenesis, effecting apoptosis, and suppressing tumorigenesis following exposure to ultraviolet radiation.
Young
Leah C
LC
Department of Medical Genetics, University of Alberta, Edmonton, Alberta, Canada T6G 2H7. leah.young@ualberta.ca
Hays
John B
JB
Tron
Victor A
VA
Andrew
Susan E
SE
D000818:Animals; D004260:DNA Repair / Q000502:physiology / Q000528:radiation effects*; D004268:DNA-Binding Proteins / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic / Q000528:radiation effects*; D006801:Humans; D014466:Ultraviolet Rays / Q000009:adverse effects*
D004268:DNA-Binding Proteins