[Ionic mechanisms underlying the regulation of cell proliferation, differentiation and death].
Ion channels and transporters act as major components that regulate membrane excitability in neurons, muscles, and some secretory glands, but may also contribute to the regulation of proliferation, differentiation, and death in a greater variety of cells including non-excitable ones. The molecular basis of ionic mechanisms underlying the later regulation has been partly identified in the last several years and is a hot issue now. In this short review, some of the molecular mechanisms underlying these regulations and novel compounds acting on the mechanisms were introduced as exciting topics in this area. Several types of transient receptor potential (TRP), identified as Ca(2+)-permeable, non-selective cation channels, may play obligatory roles in functional complexes, which regulate multiple signal transduction pathways triggering proliferation, differentiation, or death of many cell types. In addition, the relation between Cl(-) pump activity and the induction of beta-amyloid protein toxicity for neuronal cell death in Alzheimer disease was described. Unique functions of H(+) channel and pump in osteoclasts in bone mineral homeostasis and remodeling were also discussed. Finally, topics about activation of specific types of Cl(-) channels and K(+) channels, which are responsible for the induction of apoptosis or proliferation in several types of cells, were introduced.
Mori
Yasuo
Y
Ctr. Integ. Biosci., Okazaki Natl. Res. Inst., Japan.
Inagaki
Chiyoko
C
Kuno
Miyuki
M
Inoue
Ryuji
R
Okada
Yasunobu
Y
Imaizumi
Yuji
Y
D000544:Alzheimer Disease / Q000209:etiology; D000818:Animals; D017209:Apoptosis; D016723:Bone Remodeling; D002454:Cell Differentiation; D002455:Cell Division; D015195:Drug Design; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D017136:Ion Transport / Q000502:physiology*; D008565:Membrane Proteins; D010010:Osteoclasts / Q000502:physiology; D015398:Signal Transduction; D050053:TRPM Cation Channels
D007473:Ion Channels; D008565:Membrane Proteins; D050053:TRPM Cation Channels; C121934:TRPM2 protein, human