title: Recurring thrombocytopenia associated with structured treatment interruption in patients with human immunodeficiency virus infection.
abstract: In a structured treatment interruption (STI) trial, 3 of 23 patients in a CD4 cell count-guided treatment arm developed recurring thrombocytopenia associated with the interruption of antiretroviral therapy. All 3 patients had slightly low or normal platelet counts before initiating antiretroviral therapy. STI may play a role in inducing thrombocytopenia in patients with human immunodeficiency virus infection.
authors.affiliation: Human Immunodeficiency Virus Netherlands Australia Thailand Research Collaboration and Thai Red Cross Acquired Immunodeficiency Syndrome Research Center, Pathumwan, Bangkok, Thailand 10330. jintanat.a@chula.ac.th
authors.forename: Jintanat
authors.initials: J
authors.lastname: Ananworanich
authors.forename: Nittaya
authors.initials: N
authors.lastname: Phanuphak
authors.forename: Reto
authors.initials: R
authors.lastname: Nuesch
authors.forename: Wichitra
authors.initials: W
authors.lastname: Apateerapong
authors.forename: Ponlapat
authors.initials: P
authors.lastname: Rojnuckarin
authors.forename: Sasiwimol
authors.initials: S
authors.lastname: Ubolyam
authors.forename: Praphan
authors.initials: P
authors.lastname: Phanuphak
authors.forename: Kiat
authors.initials: K
authors.lastname: Ruxrungtham
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D004334:Drug Administration Schedule; D015658:HIV Infections / Q000188:drug therapy* / Q000201:enzymology; D017320:HIV Protease Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000209:etiology*
chemical_list: D017320:HIV Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors