Twin pregnancy obtained with frozen-thawed embryos after in vitro maturation in a patient with polycystic ovarian syndrome.
OBJECTIVE
A twin pregnancy was obtained in a patient with polycystic ovary syndrome after the transfer of three in vitro maturation-derived day 3 embryos that has been frozen and thawed.


METHODS
The patient had received mild hMG stimulation followed by hCG injection. After culture for 24-48 h, mature oocytes were fertilized by ICSI. Embryos were cultured until day 3; supernumerary embryos were cryopreserved using a slow protocol.


RESULTS
Among 15 nonatretic oocytes, 9 matured, 8 were fertilized. Four embryos were transferred but they did not implant. The subsequent transfer of three frozen-thawed embryos resulted in the delivery of two healthy girls.


CONCLUSIONS
These results indicate that a pregnancy could be obtained with in vitro maturation-derived day-3 frozen-thawed embryos.
Godin
P-A
PA
Gynecology-Obstetrics Department, Citadelle Hospital, Liège, Belgium.
Gaspard
O
O
Thonon
F
F
Jouan
C
C
Wijzen
F
F
Dubois
M
M
Foidart
J-M
JM
D000328:Adult; D015925:Cryopreservation; D004624:Embryo Transfer; D004622:Embryo, Mammalian; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D011085:Polycystic Ovary Syndrome; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D014427:Twins