[Study on the characters of hydrogen bonds in protein and nucleic acid of the breast cancer tissues].
Some remarkable spectral differences are observed between the normal breast tissues and breast cancer tissues, including those of association pattern and degree of the hydrogen bonds in the protein and nucleic acid biomacromolecules. These differences are found in the relative intensity, absorption position and shape of the characteristic bands: (1) amide I band, stretching vibration bands of N-H group and C-O(H) in the residues of some amino-acids, and (2) the relative intensity of asymmetric stretching vibration of the phosphodiester group in nucleic acid. The hydrogen bond is the major force which maintain and promote the formation of the high structure of protein and nucleic acid. It is possible to diagnose the breast cancer and forecast the possibility of canceration using above spectral characters of the hydrogen bond with other spectral characters.
Huo
H
H
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116012, China.
Wang
X F
XF
Che
X
X
Huang
W D
WD
D000577:Amides; D000596:Amino Acids; D001940:Breast / Q000737:chemistry; D001943:Breast Neoplasms / Q000737:chemistry*; D004273:DNA, Neoplasm / Q000737:chemistry*; D006801:Humans; D006860:Hydrogen Bonding; D046911:Macromolecular Substances; D009363:Neoplasm Proteins / Q000737:chemistry*; D009696:Nucleic Acids / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D014732:Vibration
D000577:Amides; D000596:Amino Acids; D004273:DNA, Neoplasm; D046911:Macromolecular Substances; D009363:Neoplasm Proteins; D009696:Nucleic Acids; D011506:Proteins