[Mechanisms of development of neurodegenerative processes in multiple sclerosis: neuroprotective influence of beta-interferons today and neurotrophic factors -- tomorrow].
The review addresses an analysis of the causes of neurodegenerative process development in multiple sclerosis (MS) as well as the modern approaches to the treatment of the disease. The best-studied mechanisms of degenerative alterations and clinical and experimental evidence supported the protective influence of beta-interferons treatment in MS are discussed. Neuroprotection is highlighted among the future directions. The main features of the various groups of neurotrophic factors and the possible ways of their therapy-targeted transport into brain tissues are analyzed.
Boĭko
A N
AN
Petrov
S V
SV
Nesterova
V A
VA
Gusev
E I
EI
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D001284:Atrophy / Q000473:pathology; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002531:Cerebellum / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use*; D009682:Magnetic Resonance Spectroscopy; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*
D000276:Adjuvants, Immunologic; D019208:Brain-Derived Neurotrophic Factor; D016899:Interferon-beta