A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice.
We have studied the genetics of susceptibility to infection by Streptococcus pneumoniae in mice. Linkage analysis of the F(2) generation from a cross between resistant BALB/cO1aHsd and susceptible CBA/CaO1aHsd strains allowed us to map a major locus controlling the development of bacteremia and survival after intranasal infection.
Denny
Paul
P
MRC UK Mouse Genome Centre & Mammalian Genetics Unit, Harwell, Oxon, OX11 0RD, UK. paul@har.mrc.ac.uk
Hopes
Elaine
E
Gingles
Neill
N
Broman
Karl W
KW
McPheat
William
W
Morten
John
J
Alexander
Janet
J
Andrew
Peter W
PW
Brown
Steve D M
SD
D000818:Animals; D003433:Crosses, Genetic; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D011008:Pneumococcal Infections / Q000235:genetics*; D013296:Streptococcus pneumoniae