[Oxygen transport in skeletal muscles working with its maximum consumption during hypoxemia].
The influence of acute hypoxia (35 < or = PaO2 < or = 100 mmHg) on the values of VO2max and parameters of oxygen transport in muscle working at VO2max was studied under different values of muscle blood flow F (80 < or = F < or = 120 ml/(min 100g), blood pH (7.0-7.6), and different diffusion conditions. Investigations were performed on a computer model of O2 delivery to and O2 consumption in the working muscle. VO2max, pvO2, PO2- and VO2-fields in the muscular fiber were calculated. It was shown that the greater the degree of arterial hypoxemia, the lower the muscle VO2max and PvO2 values. The greater the blood flow through muscle, the greater the VO2max. The diffusion conditions produced a powerful influence on the VO2max value. However, with an increasing degree of arterial hypoxemia, the effect of F, intercapillary distances, and blood pH on the value of VO2max is weakened.
Man'kovs'ka
I M
IM
A.A. Bogomoletz Institute of Physiology National Academy, V.M. Glushkov Institute of Cybernetics NAS of Ukraine, Kiev.
Liabakh
K H
KH
D006801:Humans; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000098:blood supply / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*; D010313:Partial Pressure; D012039:Regional Blood Flow / Q000502:physiology
D010100:Oxygen