title: Synthesis and biodistribution of two novel 99mTc( SNN/S) "3+1" mixed ligand complexes as potential brain perfusion agents.
abstract: Two novel [99mTc] [ SNN/S] "3+1" mixed ligand complexes, where L3H2= o-methylthio-glycinanilide (A) or N-(1-methylthio-phenyl)-ethylenediamine (B) and L1H= isopropanethiol, were synthesized using stannous chloride as reductant and glucoheptonate as transfer ligand. The identifications of [99mTc]-A and [99mTc]-B were established by thin layer chromatography. The radiochemical purity of both complexes was over 90%. The initial biodistribution study in mice demonstrated that both complexes can penetrate the intact blood-brain barrier and exhibit retention in mice brain. The brain uptake (%ID/g) values of [99mTc]-A were 1.68, 1.23, 1.24 and of [99mTc]-B were 1.76, 1.08, 0.90 at 2, 30 and 60 min i.v. postinjection, respectively.
authors.affiliation: College of Basic Science and Technology, Beijing Forestry University, Beijing 100083, China.
authors.forename: Xin-hong
authors.initials: XH
authors.lastname: Duan
authors.forename: Gong-xu
authors.initials: GX
authors.lastname: Lu
authors.forename: Xue-bin
authors.initials: XB
authors.lastname: Wang
mesh_terms: D000818:Animals; D001822:Body Burden; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D007275:Injections, Intravenous; D051379:Mice; D009928:Organ Specificity; D015609:Organotechnetium Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D011829:Radiation Dosage; D011874:Radiometry; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000097:blood / Q000138:chemical synthesis / Q000378:metabolism; D014018:Tissue Distribution; D014915:Whole-Body Counting
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C478618:technetium 99m (isopropanethiol)(N-(1-methylthiophenyl)ethylenediamine); C478617:technetium 99m (isopropanethiol)(o-methylthioglycinanilide)