title: Huntington's disease: a decade beyond gene discovery.
abstract: Huntington's disease is a dominantly inherited neurodegenerative disease that causes a progressive movement disorder, cognitive decline, and varying degrees of psychiatric dysfunction. The identification of the mutant gene in 1993 paved the way for a decade of basic research. The resultant advances in our understanding of the pathogenesis of the disorder are moving us toward rational therapies to slow the progression and delay the onset of the illness.
authors.affiliation: Oregon Health & Science University, Campus Mail OP-32, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA. hogarthp@ohsu.edu
authors.forename: Penelope
authors.initials: P
authors.lastname: Hogarth
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic / Q000379:methods; D015316:Genetic Therapy / Q000379:methods / Q000639:trends*; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology