title: [In vivo Terbinafine inefficacy on cutaneous leishmaniasis caused by Leishmania (Leishmania) amazonensis in C57BL/6 mice].
abstract: The efficiency of terbinafine was tested in C57BL/6 mice inoculated with the Leishmania (Leishmania) amazonensis strain MHOM/BR/PH8. The mice were administered: terbinafine at a dose of 100mg/kg/d by via oral; 0.9% saline solution orally as the control; and subcutaneous sodium stibogluconate 400mg SbV/kg/d as gold standard, for 20 days. Terbinafine was demonstrated to be ineffective when compared to the controls, using clinical and parasitological parameters and the limiting dilution assay.
authors.affiliation: Laboratório de Dermatomicologia, Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brasil. mrsampaio@hotmail.com
authors.forename: Raimunda Nonata Ribeiro
authors.initials: RN
authors.lastname: Sampaio
authors.forename: Gustavo Henrique Soares
authors.initials: GH
authors.lastname: Takano
authors.forename: Ana Cristina Barbieri
authors.initials: AC
authors.lastname: Malacarne
authors.forename: Tércio Rodrigues
authors.initials: TR
authors.lastname: Pereira
authors.forename: Albino Verçosa
authors.initials: AV
authors.lastname: de Magalhães
mesh_terms: D000818:Animals; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009281:Naphthalenes / Q000627:therapeutic use*; D000077291:Terbinafine
chemical_list: D000981:Antiprotozoal Agents; D004791:Enzyme Inhibitors; D009281:Naphthalenes; D000077291:Terbinafine; D000967:Antimony Sodium Gluconate