Pneumocystis carinii, cytomegalovirus, and severe transient immunodeficiency.
Pneumocystis carinii infection is rare in infants, and raises strong concerns of immune deficiency. This report describes the unusual case of a male infant with concurrent chest infections caused by P carinii and cytomegalovirus. Investigation was complicated by the strong suspicion of non-accidental injury, including subdural haematomas. The case illustrates how to investigate for possible immunodeficiency. Low immune function tests at presentation slowly improved and have remained normal on longterm follow up. Possible explanations for the transient severe clinical immunodeficiency in this case are discussed.
Rowling
A J
AJ
Kvalsvig
A J
AJ
Sharples
P M
PM
Foot
A B
AB
Unsworth
D J
DJ
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002649:Child Abuse; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000151:congenital* / Q000188:drug therapy; D015774:Ganciclovir / Q000627:therapeutic use; D006408:Hematoma, Subdural / Q000150:complications / Q000601:surgery; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000150:complications* / Q000188:drug therapy; D012253:Rib Fractures / Q000150:complications; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D015774:Ganciclovir