The use of solid self-emulsifying systems in the delivery of diclofenac.
Goat fat and Tween 65 admixtures were used to formulate self-emulsifying tablets containing diclofenac. The tablets were formulated by pour moulding using a plastic mould. The tablets were evaluated using the following parameters: weight uniformity, absolute drug content, and liquefaction time. The dissolution profile of diclofenac from the self-emulsifying tablets was determined in simulated gastric fluid (SGF) without pepsin. Results obtained indicated that diclofenac could be comfortably administered in the form of self-emulsifying tablets using goat fat and Tween 65 admixtures.
Attama
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AA
Department of Pharmaceutics, Drug Delivery Research Unit, University of Nigeria, Nsukka, Enugu State, Nigeria. aaattama@yahoo.com
Nzekwe
I T
IT
Nnamani
P O
PO
Adikwu
M U
MU
Onugu
C O
CO
D000273:Adipose Tissue; D000818:Animals; D002626:Chemistry, Pharmaceutical; D004008:Diclofenac / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding; D016503:Drug Delivery Systems; D004655:Emulsions; D006041:Goats; D007700:Kinetics; D011136:Polysorbates / Q000737:chemistry; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry*; D013607:Tablets
D004655:Emulsions; D011136:Polysorbates; D013501:Surface-Active Agents; D013607:Tablets; D004008:Diclofenac