Synthesis and cytotoxicity evaluation of novel C7-c7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamide conjugates.
The C7-C7, C7-N3 and N3-N3 dimers of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benzo[e]indole (seco-CBI) with pyrrole and imidazole polyamides were synthesized and preliminary anti-cancer evaluation carried out by NCI against three types of cancer cells.
Kumar
Rohtash
R
Department of Chemistry, University of Alberta, Edmonton, AB, Canada T6G2G2.
Lown
J William
JW
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D019281:Dimerization; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D007093:Imidazoles / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D007093:Imidazoles; D007211:Indoles; D011758:Pyrroles; C470729:polyamide 1-(chloromethyl)-5-hydroxyl-1,2-dihydro--3H-benz(e)indole conjugate