title: Biological activity of serotonin conjugates from the seeds of Centaurea nigra.
abstract: Two serotonin conjugates, N-(trans-p-coumaroyl)-serotonin (1) and N-(trans-feruloyl)-serotonin (maoschamine, 2), isolated from the methanol extract of the seeds of Centaurea nigra, have been assessed for antibacterial and free radical scavenging activities. The general toxicity of 1 and 2 has also been determined by the brine shrimp lethality bioassay.
authors.affiliation: Phytopharmaceutical Research Laboratory, School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen, AB10 1FR, Scotland, UK.
authors.forename: Y
authors.initials: Y
authors.lastname: Kumarasamy
authors.forename: M
authors.initials: M
authors.lastname: Middleton
authors.forename: R G
authors.initials: RG
authors.lastname: Reid
authors.forename: L
authors.initials: L
authors.lastname: Nahar
authors.forename: S D
authors.initials: SD
authors.lastname: Sarker
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001156:Artemia / Q000187:drug effects; D031179:Centaurea; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012639:Seeds; D012701:Serotonin / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D016166:Free Radical Scavengers; D010936:Plant Extracts; D012701:Serotonin