[Effects of overdriving pacing preconditioning on the activity of antioxidase in the coronary sinus during the ischemia-reperfusion].
OBJECTIVE
To evaluate the effects of early and delayed overdriving pacing preconditioning on the concentration of nitric oxide (NO), superoxide dismutase (SOD) and malondialdehyde (MDA) in blood.


METHODS
Forty-eight rabbits were divided into control (C) group, ischemia-reperfusion (IR) group, overdriving pacing preconditioning (PP) group and delayed protection (DP) group. The concentrations of NO, SOD, MDA in the coronary sinus were detected during the ischemia-reperfusion.


RESULTS
The levels of NO in the coronary sinus of PP and DP group were higher than that of IR group, the levels of MDA of PP and DP group were lower than that of IR group.


CONCLUSIONS
PP and DP could alleviate the injury by the oxygen free radicals during the myocardial ischemia-reperfusion.
Lin
Xiao-hong
XH
Department of Emergency, The Affiliated Union Hospital, Fujian Medical University, Fuzhou 350001, Fujian, China.
Wu
Li-ming
LM
D000818:Animals; D054326:Coronary Sinus / Q000503:physiopathology*; D019194:Ischemic Preconditioning; D015428:Myocardial Reperfusion Injury; D009569:Nitric Oxide / Q000378:metabolism*; D011817:Rabbits
D009569:Nitric Oxide