Successful treatment of human immunodeficiency virus-related Castleman's disease: a case report and literature review.
Multicentric Castleman's disease is increasingly recognized as an aggressive illness with a rapidly fatal outcome in human immunodeficiency virus (HIV)-infected patients. In the absence of optimal therapy, various therapeutic interventions have been tested with disappointing results; only five reports with a successful outcome have been described. Presented herein is a 66-year-old HIV-infected man with multicentric Castleman's disease. Early administration of cyclophosphamide, doxorubicin, vincristine and prednisone resulted in prolonged clinical recovery. The relevant literature is also reviewed.
Liberopoulos
Evagelos
E
Department of Internal Medicine, University of Ioannina Medical School, Ioannina, Greece.
Tolis
Christos
C
Bai
Mary
M
Efremidis
Stavros
S
Pavlidis
Nikolaos
N
Elisaf
Moses
M
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005871:Castleman Disease / Q000188:drug therapy* / Q000473:pathology* / Q000821:virology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D010950:Plasma Cells / Q000473:pathology; D013163:Splenomegaly / Q000000981:diagnostic imaging / Q000821:virology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome