title: Changes in immunological parameters in patients with opium abuse receiving ANAR therapy.
abstract: We studied the effects of ANAR containing antibodies to morphine in ultralow doses on immunological parameters in patients with opium abuse. Changes in blood content of immunocompetent CD3+, CD16+, and HLA-DR+ cells, lymphocytes carrying receptors for serotonin and dopamine, and humoral immune factors were evaluated. As differentiated from standard preparations, ANAR possessed immunomodulatory properties, increased the content of HLA-DR+ lymphocytes and immunoglobulins in the blood, and normalized the number of CD16+ cells.
authors.affiliation: Laboratory of Clinical Psychoneuroimmunology, Department of Addictions, Institute of Mental Health, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
authors.forename: T P
authors.initials: TP
authors.lastname: Vetlugina
authors.forename: S A
authors.initials: SA
authors.lastname: Ivanova
authors.forename: N A
authors.initials: NA
authors.lastname: Bokhan
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use*; D017252:CD3 Complex / Q000276:immunology; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009020:Morphine / Q000276:immunology; D009293:Opioid-Related Disorders / Q000188:drug therapy* / Q000276:immunology*; D017452:Receptors, IgG / Q000276:immunology; D055815:Young Adult
chemical_list: D000906:Antibodies; D017252:CD3 Complex; D006684:HLA-DR Antigens; D007136:Immunoglobulins; D017452:Receptors, IgG; D009020:Morphine