Physical and cytological characters of carbon, titanium surface modified intraocular lens in rabbit eyes.
OBJECTIVE
To evaluate the physical and cytological characters of carbon (C), titanium (T) surface-modified intraocular lenses (IOLs) in rabbit eyes.


METHODS
Water contact angle in air of C, T-IOLs was measured by goniometer using the sessile drop method. Extracapsular cataract extraction (ECCE) and IOL implantation were performed in rabbit eyes. Cells adhering to IOLs were measured using the MIAS-2000 Computer Analyzer System at 12 months after operation. The diopters and resolution of C, T-IOLs were measured after 1 year of implantation.


RESULTS
Water contact angle in air of C, T-IOLs (80, 84.5 deg) were significant lower than that of PMMA-IOL (74.8 deg). C, T-IOLs became hydrophobic compared with PMMA-IOLs. C, T-IOLs did not change significantly in diopters and resolution after 1 year of implantation in rabbit eyes. There were fibroblasts, epitheloid cells, giant cells, lymphocyte cells and fibrous membrane attached to the surface of IOLs.


CONCLUSIONS
The optical characteristics of C, T-IOL) were stable in rabbit eyes after 1 year of implantation. The C, T-IOLs became hydrophobic compared with PMMA-IOLs. They also induced foreign body reactions similar to those seen with PMMA-IOLs in rabbit eyes.
Yuan
Zhaoxu
Z
College of Optometry, State University of New York, 33 West 42nd Street, New York, NY 10036, USA. yuanzhaoxu3@yahoo.com
D000818:Animals; D002244:Carbon; D002387:Cataract Extraction; D002448:Cell Adhesion; D020099:Coated Materials, Biocompatible / Q000009:adverse effects*; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology*; D015743:Giant Cells, Foreign-Body / Q000473:pathology; D019654:Lens Implantation, Intraocular / Q000009:adverse effects; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D019904:Polymethyl Methacrylate; D011817:Rabbits; D014025:Titanium
D020099:Coated Materials, Biocompatible; D002244:Carbon; D019904:Polymethyl Methacrylate; D014025:Titanium