POPing the fire into the pyrin?
Initiation of an inflammatory response requires the co-ordinated participation of proteins within a scaffold in the cytosol of responding cells. The scaffold proteins contain members of a newly discovered family of pyrin-domain adaptor proteins that regulate complex assembly for initiation of nuclear factor kappaB and interleukin-1beta signalling. A paper in this issue of the Biochemical Journal by Stehlik et al. identifies a new member of the pyrin family that may control signalling by sequestering pro-inflammatory components, shedding light on the origin of human inflammatory disorders.
Mariathasan
Sanjeev
S
Department of Molecular Oncology, Genentech, Inc., South San Francisco, CA 94080, USA.
Vucic
Domagoj
D
D000818:Animals; D051017:Apoptosis Regulatory Proteins; D053468:CARD Signaling Adaptor Proteins; D002352:Carrier Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000235:genetics; D017434:Protein Structure, Tertiary / Q000235:genetics / Q000502:physiology; D012261:Ribonucleoproteins; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
D051017:Apoptosis Regulatory Proteins; D053468:CARD Signaling Adaptor Proteins; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; C490350:POP1 protein, human; C402202:PYCARD protein, human; D012261:Ribonucleoproteins