title: Successful treatment of human granulocytic ehrlichiosis in children using rifampin.
abstract: Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne infectious disease caused by Anaplasma phagocytophilum. Clinical features include a flu-like illness that usually resolves within 1 week. More serious infection may occur that requires hospital admission or culminates in death. Doxycycline is the treatment of choice for HGE but may cause permanent staining of teeth in children younger than 8 years of age. We report successful treatment of HGE with rifampin in 2 children, 4 and 6 years old. A course of rifampin for 5 to 7 days should be considered in children younger than 8 years of age who experience non-life-threatening A phagocytophilum infection.
authors.affiliation: Department of Pediatrics, University of Connecticut School of Medicine and Connecticut Children's Medical Center, Hartford, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Krause
authors.forename: Cathy L
authors.initials: CL
authors.lastname: Corrow
authors.forename: Johan S
authors.initials: JS
authors.lastname: Bakken
mesh_terms: D041081:Anaplasma phagocytophilum / Q000187:drug effects / Q000276:immunology / Q000302:isolation & purification; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D002648:Child; D002675:Child, Preschool; D016873:Ehrlichiosis / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D012293:Rifampin / Q000627:therapeutic use*
chemical_list: D000907:Antibodies, Bacterial; D012293:Rifampin