title: Pharmacological activity of phenazepam and flunitrazepam in ultralow doses.
abstract: Experiments on male outbred albino rats showed that benzodiazepine tranquilizers phenazepam and flunitrazepam in ultralow doses (10(-9)-10(-15) mol/kg) produced an anxiolytic effect in the conflict situation test. This effect was not accompanied by myorelaxing and sedative side effects typical of standard doses of tranquilizers.
authors.affiliation: Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
authors.forename: G M
authors.initials: GM
authors.lastname: Molodavkin
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
authors.forename: L I
authors.initials: LI
authors.lastname: Chernyavskaya
authors.forename: E B
authors.initials: EB
authors.lastname: Burlakova
authors.forename: N I
authors.initials: NI
authors.lastname: Khorseva
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001569:Benzodiazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005445:Flunitrazepam / Q000494:pharmacology*; D008297:Male; D008472:Medazepam / Q000494:pharmacology; D051381:Rats; D014149:Tranquilizing Agents / Q000494:pharmacology*
chemical_list: D014151:Anti-Anxiety Agents; D014149:Tranquilizing Agents; D001569:Benzodiazepines; C017928:phenazepam; D005445:Flunitrazepam; D008472:Medazepam