The completed human genome: implications for chemical biology.
The recently completed human genome sequence represents an enormous opportunity to understand biology and accelerate the development of new therapeutics. However, it also presents equally large logistical, scientific and paradigmatic challenges to efficiently translate the enormous cache of sequence data into functional information that will be the precursor of new drug development. Small-molecule chemical biology applied on a genomic scale promises to speed this translation to novel therapeutics.
Austin
Christopher P
CP
National Human Genome Research Institute, National Institutes of Health Building 31, Room 4B09, 31 Center Drive, Bethesda, MD 20892, USA. austinc@mail.nih.gov
D000818:Animals; D030541:Databases, Genetic; D015195:Drug Design; D015723:Gene Library; D015894:Genome, Human; D006801:Humans; D008967:Molecular Biology / Q000639:trends*; D012045:Regulatory Sequences, Nucleic Acid; D017422:Sequence Analysis, DNA; D016324:Sequence Tagged Sites