title: Serum biochemical markers in carcinoma breast.
abstract: BACKGROUND
  Despite the extensive research for many years throughout the world, the etiopathogenesis of cancer still remains obscure. For the early detection of carcinoma of various origins, a number of biochemical markers have been studied to evaluate the malignancy.
  
  
  OBJECTIVE
  To analyse serum gamma glutamyl transpeptidase (GGTP), lactate dehydrogenase (LDH) and superoxide dismutase (SOD) in carcinoma breast patients.
  
  
  METHODS
  The serum biochemical markers were estimated in twenty five histopathologically confirmed patients with carcinoma breast and equal number of healthy age- matched individuals served as control.
  
  
  METHODS
  Serum gamma glutamyl transpeptidase (GGTP), lactate dehydrogenase (LDH) and superoxide dismutase (SOD) were estimated and their sensitivity determined.
  
  
  METHODS
  Data was analysed with student's 't'-test and sensitivity score of these markers was determined.
  
  
  CONCLUSIONS
  The mean serum GGTP, LDH and SOD activities in patients with carcinoma breast were tremendously increased as compared to controls, and a steady increase was observed in their activities from stage I through stage IV as well as following distant metastasis. Serum GGTP, LDH and SOD might prove to be most sensitive biomarkers in carcinoma breast in early detection of the disease.
authors.affiliation: Department of Biochemistry, Pt. B.D. Sharma PGIMS, Rohtak, Haryana.
authors.forename: Late R K
authors.initials: LR
authors.lastname: Seth
authors.forename: Simmi
authors.initials: S
authors.lastname: Kharb
authors.forename: D P
authors.initials: DP
authors.lastname: Kharb
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000097:blood; D018275:Carcinoma, Lobular / Q000097:blood; D018450:Disease Progression; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D009367:Neoplasm Staging; D012016:Reference Values; D012680:Sensitivity and Specificity; D013482:Superoxide Dismutase / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D005723:gamma-Glutamyltransferase