Immunological mechanisms of adaptation to the low-weight chemical compounds in ontogenesis.
It is postulated that adaptation to the low-weight chemical compounds includes six consistent ontogenetic periods: the reciprocal selection of the marriage partners; the maturation of the gametes; the formation of the zygote; the development of the fetus; the birth and nursing of the child; and the sexual maturation of a human being. The main immunological parts of adaptation are: the antibodies to the low-weight xeno- and endobiotics; the reciprocal immune-like recognition of the maternal and paternal gametes; and the maternal immune reaction on the paternal histocompatibility antigens of the fetus. The main immunological mechanisms of adaptation are: the promotion of the selectivity in the smell recognition of the marriage partners by the antibodies to the xeno- and endobiotics expanding the individual spectrum of their metabolites; the inhibition of the xenobiotic genotoxic action on the gametes, fetus and child by the antibodies; the prevention of the development of gene-damaged gametes and fetus by antibodies to the sexual hormones; and the immune preservation (elimination) of the heterozygote (homozygote) fetus.
Glushkov
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Department of Cancer Immunology, Kemerovo Science Center, Russian Academy of Sciences, Kemerovo, Russia. glushkov@ksma.kuzstu.ac.ru
D000222:Adaptation, Physiological / Q000276:immunology*; D000818:Animals; D001711:Biotransformation; D005260:Female; D006649:Histocompatibility Antigens / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology*; D008297:Male; D008970:Molecular Weight; D011247:Pregnancy; D013997:Time Factors; D015262:Xenobiotics / Q000633:toxicity*
D006649:Histocompatibility Antigens; D015262:Xenobiotics