[Cell differentiation in human melanoma cells caused by dicarbamine (ultrastructural investigation)].
The effects of dicarbamine (r) and polytransretinoic acid (PTRA) on human melanoma MEL-6 transplanted into Balb/c nude female mice have been compared by histological and electron microscopic procedures. It was discovered that long-term administration of 1.5 mg/kg dicarbamine caused melanoma MEL-6 cells to undergo terminal differentiation. As a result, the number of melanosome-containing cells was 3-4 times and the number of melanosomes in them--5 times those in intact controls. Dicarbamine effect was double that of PTRA.
Raĭkhlin
N T
NT
N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences.
Nebol'sin
V E
VE
Zheltukhina
G A
GA
Bryzgalov
I P
IP
Sorokina
Iu D
IuD
Andronova
N V
NV
Sedakova
L A
LA
Smirnova
E A
EA
Treshchalina
E M
EM
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002219:Carbamates / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D006801:Humans; D007150:Immunohistochemistry; D008543:Melanins / Q000032:analysis*; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000648:ultrastructure*; D020460:Melanosomes / Q000737:chemistry / Q000187:drug effects*; D051379:Mice; D008819:Mice, Nude; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D014212:Tretinoin / Q000494:pharmacology*
D000970:Antineoplastic Agents; D002219:Carbamates; D008543:Melanins; D014212:Tretinoin