title: Changes in some indices of the synthesis of nitric oxide during the early stages of hepatocarcinogenesis.
abstract: Our objective in this study was to determine some indices of the synthesis of nitric oxide during the early periods of diethylnitrosamine-induced hepatocarcinogenesis in mature male rats and to gain insights into their relationship to lipid peroxidation. The basis for the study was the intragastric administration of 10 mg/kg diethylnitrosamine 5 times a week for two months to 28 male rats; 12 additional rats served as untreated controls. During the time-related course of hepatocarcinogenesis, the blood serum level of L-arginine was found to decrease significantly while that of malondialdehyde tended to increase. The superoxide dismutase (SOD) activity increased somewhat during the period of initiation. A significant reduction of SOD was recorded during the period of promotion and a striking increase occurred in the initial period of progression. Unlike SOD, catalase showed a tendency to increase after some initial decline in its activity.
authors.affiliation: Central Scientific Laboratory, Second Tashkent State Medical Institute, Tashkent, Republic of Uzbekistan. tashmi2@online.ru
authors.forename: Kh Ya
authors.initials: KhY
authors.lastname: Karimov
authors.forename: F Kh
authors.initials: FKh
authors.lastname: Inoyatova
authors.forename: M T
authors.initials: MT
authors.lastname: Mukhamedova
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001120:Arginine / Q000097:blood; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity; D002374:Catalase / Q000378:metabolism; D004052:Diethylnitrosamine / Q000008:administration & dosage / Q000633:toxicity; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis*; D009573:Nitrites / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors
chemical_list: D002273:Carcinogens; D009573:Nitrites; D009569:Nitric Oxide; D004052:Diethylnitrosamine; D008315:Malondialdehyde; D001120:Arginine; D002374:Catalase; D013482:Superoxide Dismutase