Displacement of primary sensorimotor cortex activation after subcortical stroke: a longitudinal PET study with clinical correlation.
Five patients with left striatocapsular infarction were studied twice with PET during auditory-cued right thumb-index tapping, around 2 months after stroke and again around 8 months after stroke. At PET1 and PET2, the ipsilesional primary sensorimotor (SM1) activation peak Talairach coordinates were compared to those from seven aged-matched healthy controls. At PET1, there was a significant posterior displacement of SM1 activation peak, which confirms a previous report and may represent unmasking/disinhibition of motor representations. Over time, there was no significant change in the coordinates, and no significant correlation between coordinate changes from PET1 to PET2 and concomitant motor recovery. The implications of posterior displacement of SM1 activation peak for recovery therefore remain elusive.
Calautti
Cinzia
C
Department of Neurology, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
Leroy
Francois
F
Guincestre
Jean-Yves
JY
Baron
Jean-Claude
JC
D000161:Acoustic Stimulation; D001931:Brain Mapping; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006429:Hemiplegia / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D020772:Internal Capsule / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011597:Psychomotor Performance / Q000502:physiology*; D013003:Somatosensory Cortex / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014055:Tomography, Emission-Computed / Q000379:methods*