title: Cellular and molecular mechanisms of neuronal migration in neocortical development.
abstract: The complicated mammalian brain structure arises from accurate movements of neurons from their birthplace to their final locations. Detailed observation of this migration process by various methods revealed that neuronal migration is highly motile and that there are different modes of migration. Moreover, mouse mutants or human disorders that disrupt normal migration have provided significant insights into molecular pathways that control the neuronal migration. Although our knowledge is still fragmentary, it is becoming clear that various molecules are participating in this process. In this review, we outline about the cellular and molecular mechanisms of neuronal migration in the cerebral cortex.
authors.affiliation: Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Honda
authors.forename: Hidenori
authors.initials: H
authors.lastname: Tabata
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nakajima
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D019579:Neocortex / Q000166:cytology* / Q000196:embryology*; D009474:Neurons / Q000166:cytology* / Q000502:physiology*