Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira.
From the aerial parts of Cissampelos pareira L. (Menispermaceae), a chalcone-flavone dimer has been isolated which, mainly from NMR spectroscopic and MS data, was proved to be 2-(4-hydroxy-3-methoxyphenyl)-7-(4-methoxyphenyl)-6-(2-hydroxy-4,6-dimethoxybenzoyl)-furano[3,2-g]benzopyran-4-one. This has been assigned the trivial name cissampeloflavone. The compound has good activity against Trypanosoma cruzi and T. brucei rhodesiense and has a low toxicity to the human KB cell line.
Ramírez
Irama
I
Faculty of Pharmacy, University of Los Andes, Mérida ZP-5101, Venezuela.
Carabot
Alfredo
A
Meléndez
Pablo
P
Carmona
Juan
J
Jimenez
Manuel
M
Patel
Asmita V
AV
Crabb
Trevor A
TA
Blunden
Gerald
G
Cary
Peter D
PD
Croft
Simon L
SL
Costa
Manuel
M
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002599:Chalcone / Q000031:analogs & derivatives* / Q000302:isolation & purification* / Q000494:pharmacology; D031606:Cissampelos / Q000737:chemistry*; D019281:Dimerization; D056890:Eukaryota / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D035261:Plant Components, Aerial / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D000981:Antiprotozoal Agents; D005419:Flavonoids; D002599:Chalcone