title: Malignant obstructive jaundice: comparison of MRCP and ERCP in the evaluation of distal lesions.
abstract: OBJECTIVE
  To compare the diagnostic accuracy of MR cholangiopancreatography (MRCP) and endoscopic retrograde cholangiopancreatography (ERCP) in the diagnosis of malignant stenosis of the distal common bile duct.
  
  
  METHODS
  Twenty-one patients (12 males and 9 females, mean age 62 years) with a clinical suspicion of malignancy of the distal biliary tract and pancreatic head underwent tomographic RM evaluation and diagnostic MRCP, followed by diagnostic and, where possible, therapeutic ERCP. The images obtained with ERCP and MRCP were reviewed blind by two experts who evaluated the presence, site, signal features and locoregional extension of the tumours. Histology performed by brushing or biopsy during ERCP and after surgical resection provided the standard of reference for all 21 patients.
  
  
  RESULTS
  CPRM correctly identified the presence and site of the distal biliary stenosis in 21/21 (100%) cases, as well as allowing evaluation of the upper abdomen by associating it with conventional MRI. ERCP, instead, allowed detection of the presence and site of biliary stenosis in 20/21 (95%) cases.
  
  
  CONCLUSIONS
  ERCP may have some limitations as regards identification of distal bile duct stenosis in cases of critical stenosis. The non-invasive nature and panoramic capabilities of MRCP and the fact that no contrast material is needed make MRCP the examination of reference in the diagnosis of malignant stenosis of the distal bile duct, also thanks to its ability to visualise the entire biliary tree in the presence of critical strictures of the common bile duct. The rationale for the use of ERCP lies in the possibility of taking histological samples and performing minimally invasive surgical interventions.
authors.affiliation: Cattedra di Radiologia, Università degli Studi di l'Aquila, L'Aquila, Italy. ernesto.dicesare@cc.univaq.it
authors.forename: Ernesto
authors.initials: E
authors.lastname: Di Cesare
authors.forename: Edoardo
authors.initials: E
authors.lastname: Puglielli
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Michelini
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Pistoi
authors.forename: Loreto
authors.initials: L
authors.lastname: Lombardi
authors.forename: Mauro
authors.initials: M
authors.lastname: Rossi
authors.forename: Antonio
authors.initials: A
authors.lastname: Barile
authors.forename: Carlo
authors.initials: C
authors.lastname: Masciocchi
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002779:Cholestasis / Q000175:diagnosis / Q000000981:diagnostic imaging; D001651:Cholestasis, Extrahepatic / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003135:Common Bile Duct; D003138:Common Bile Duct Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging