title: Effects of a large-scale intervention with influenza and 23-valent pneumococcal vaccines in elderly people: a 1-year follow-up.
abstract: To assess the effectiveness of influenza and pneumococcal vaccination in reducing hospitalisation and deaths in elderly people, the population aged > or =65 years in Stockholm County, Sweden (n = 259627) were invited to take part in a vaccination campaign with influenza and 23-valent pneumococcal vaccine (PV). A no. of persons (100,242) (vaccinated cohort) were vaccinated with one or both vaccines during the campaign. The incidence of hospital admissions during 1 year after the vaccination campaign, adjusted for sex and age, was significantly lower in the vaccinated than in the unvaccinated cohort for influenza (relative risk [RR] 0.68), pneumonia (RR 0.78), and invasive pneumococcal disease (RR 0.46). In the vaccinated cohort, the in-hospital mortality was lower for pneumonia (RR 0.55), COPD (RR 0.53) and cardiac failure (RR 0.72).
authors.affiliation: Department of Infectious Diseases, Karolinska Institutet, Karolinska Hospital, S-17176 Stockholm, Sweden. jonas.hedlund@ks.se
authors.forename: J
authors.initials: J
authors.lastname: Hedlund
authors.forename: B
authors.initials: B
authors.lastname: Christenson
authors.forename: P
authors.initials: P
authors.lastname: Lundbergh
authors.forename: A
authors.initials: A
authors.lastname: Ortqvist
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D015331:Cohort Studies; D023381:Endpoint Determination; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D017589:Immunization Programs; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D008297:Male; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000276:immunology*; D012621:Seasons; D013548:Sweden / Q000453:epidemiology; D014611:Vaccination
chemical_list: D007252:Influenza Vaccines; D022242:Pneumococcal Vaccines