[Neuroimmunoendocrine interaction in the pathogenesis of chronic heart failure].
Chronic heart failure (CHF) is a common complication of patients with heart dysfunction and of those suffering from various chronic illnesses. Although recently developed therapies revolutionized treatment of CHF, life expectancy of the survivors is still significantly reduced. Proposed neurohoromonal approach in CHF treatment is on the whole rather unsatisfactory. Recently the interest of clinical investigators has been focused on immune mechanisms in the pathogenesis of CHF. In this review we tried to summarize data concerning contribution of inflammatory cytokines to pathogenesis of CHF. The source and site of action of pro- and antiinflammatory cytokines and number of interactions among cytokines and neuroendocrine systems under CHF are considered. Finally we discuss novel therapies managing correction of both immune and neurohormonal status of the patient.
Poskrebysheva
A S
AS
Russian State Medical University, Russian Research Endocrinology Center RAMS, Institute of General Pathology and Pathological Physiology RAMS, Moscow.
Grinevich
V V
VV
Smurova
Iu V
IuV
Shostak
N A
NA
Akmaev
I G
IG
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology; D018925:Chemokines / Q000502:physiology; D002908:Chronic Disease; D016207:Cytokines / Q000502:physiology; D006333:Heart Failure / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology; D016753:Interleukin-10 / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D015213:Neuroimmunomodulation; D009490:Neurosecretory Systems / Q000503:physiopathology*; D012084:Renin-Angiotensin System / Q000502:physiology; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D018925:Chemokines; D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D009320:Atrial Natriuretic Factor