title: The association of glycolytic enzymes with cellular and model membranes.
abstract: This article deals with the binding of glycolytic enzymes with membranous or protein subcellular structures. The representative papers of the last three decades dealing with this matter are reviewed. The studies evidencing the binding of some glycolytic enzymes to insoluble subcellular proteins and membranous structures are presented. It is currently generally accepted that the glycolytic enzymes work in some organisation. Such organisation undoubtedly plays a marked role, although still poorly known, in the regulation processes of glycolysis. From this review, the conclusion emerges that the regulatory ability of the binding of glycolytic enzymes to cellular membranes should be added to the list of well-known mechanisms of post-translational regulation of the glycolytic enzymes. Some of the results presented are the background for the hypothesis that planar phospholipid domains in/on the membrane surface are capable of functioning as binding sites for these enzymes. Such binding can modify the conformation state of the enzymes, which results in changes in their kinetic properties; thus, it may function as a regulator of catalytic activity
authors.affiliation: Department of Physico-chemistry of Microorganisms, Institute of Genetics and Microbiology, Przybyszewskiego 63/77, Wrocław University, Poland. gutowicz@microb.uni.wroc.pl
authors.forename: Jan
authors.initials: J
authors.lastname: Gutowicz
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Terlecki
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000201:enzymology* / Q000378:metabolism; D006019:Glycolysis; D006801:Humans; D007700:Kinetics; D008051:Lipid Bilayers / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation
chemical_list: D008051:Lipid Bilayers