Therapeutic applications in the chemokine superfamily.
The chemokine superfamily is probably complete. There are 42 human chemokines that through interaction with 18 receptors (which belong to the GPCR superfamily-class A) play pivotal roles in many important human diseases. Here we review some of the most compelling opportunities for drug development in this area.
Houshmand
Pantea
P
Neurocrine Biosciences, 10555 Science Center Drive, San Diego, CA 92121, USA.
Zlotnik
Albert
A
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D000906:Antibodies / Q000276:immunology; D000917:Antibody Formation / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D065100:CCR5 Receptor Antagonists; D054428:Chemokine CX3CL1; D054382:Chemokine CXCL13; D018925:Chemokines / Q000276:immunology / Q000627:therapeutic use*; D020523:Chemokines, CX3C / Q000276:immunology; D019743:Chemokines, CXC / Q000276:immunology; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D007375:Interleukin-1 / Q000276:immunology; D008024:Ligands; D008562:Membrane Glycoproteins / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology; D019707:Receptors, Chemokine / Q000819:agonists* / Q000037:antagonists & inhibitors*
D000276:Adjuvants, Immunologic; D000906:Antibodies; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D065100:CCR5 Receptor Antagonists; C063419:CTAGE1 protein, human; C515538:CX3CL1 protein, human; C110663:CXCL13 protein, human; D054428:Chemokine CX3CL1; D054382:Chemokine CXCL13; D018925:Chemokines; D020523:Chemokines, CX3C; D019743:Chemokines, CXC; D007375:Interleukin-1; D008024:Ligands; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D019707:Receptors, Chemokine