Concentration of caveolin-3 at the neuromuscular junction in young and old rat skeletal muscle fibers.
Caveolin-3, a muscle-specific member of the caveolin family, is strongly localized to the neuromuscular junction (NMJ) in adult rat muscle fibers, where it co-localizes with alpha-bungarotoxin staining. In 24-month-old rats, less distinct staining corresponds with the normal aging changes in the NMJ. After denervation, the pattern and intensity of staining begin to break up as early as 3 days, and by 10 days little staining remains. The functional implications of this concentration of caveolin-3 at the NMJ remain obscure, but it is possible that its absence could account for some of the phenotypic characteristics of individuals with caveolin-3 mutations.
Carlson
Bruce M
BM
Department of Cell and Developmental Biology, University of Otago, Dunedin, New Zealand. bcarl@umich.edu
Carlson
Jean A
JA
Dedkov
Eduard I
EI
McLennan
Ian S
IS
D000367:Age Factors; D000818:Animals; D051244:Caveolin 3; D022461:Caveolins / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D008856:Microscopy, Fluorescence; D018485:Muscle Fibers, Skeletal / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000648:ultrastructure; D009469:Neuromuscular Junction / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar
C495549:Cav3 protein, rat; D051244:Caveolin 3; D022461:Caveolins