title: The association between osteoporotic fractures and health-related quality of life as measured by the Health Utilities Index in the Canadian Multicentre Osteoporosis Study (CaMos).
abstract: Osteoporotic fractures can be a major cause of morbidity. It is important to determine the impact of fractures on health-related quality of life (HRQL). A total of 3,394 women and 1,122 men 50 years of age and older, who were recruited for the Canadian Multicentre Osteoporosis Study (CaMos), participated in this cross-sectional study. Minimal trauma fractures of the hip, pelvis, spine, lower body (included upper and lower leg, knee, ankle, and foot), upper body (included arm, elbow, sternum, shoulder, and clavicle), wrist and hand (included forearm, hand, and finger), and ribs were studied. Participants with subclinical vertebral deformities were also examined. The Health Utilities Index Mark II and III Systems were used to assess HRQL. Past osteoporotic fractures varied in prevalence from 1.2% (pelvis) to 27.8% (lower body) in women and 0.3% (pelvis) to 29.3% (wrist) in men. Multivariate linear regression analyses [parameter estimates and corresponding 95% confidence intervals (CI)] indicated that minimal trauma fractures were negatively associated with HRQL and that this relationship depends on fracture type and gender. The multi-attribute scores for the Mark II system were negatively related to hip (-0.05; 95% CI: -0.09, -0.01), lower body (-0.02; 95% CI: -0.03, -0.000), and subclinical vertebral fractures (-0.02; 95% CI: -0.03, -0.00) for women. The multi-attribute scores for the Mark III system were negatively related to hip (-0.09; 95% CI: -0.14, -0.03) and rib fractures (-0.06; 95% CI: -0.11, -0.00) for women, and rib fractures (-0.06; 95% CI: -0.12, -0.00) for men. In conclusion, this study demonstrates a negative association between osteoporotic fractures and quality of life in both women and men.
authors.affiliation: Department of Medicine, St. Joseph's Hospital, McMaster University, Charlton Avenue East, Suite 501, L8 N 1Y2 Hamilton, Ontario, Canada. jd.adachi@sympatico.ca
authors.forename: J D
authors.initials: JD
authors.lastname: Adachi
authors.forename: G
authors.initials: G
authors.lastname: Ioannidis
authors.forename: L
authors.initials: L
authors.lastname: Pickard
authors.forename: C
authors.initials: C
authors.lastname: Berger
authors.forename: J C
authors.initials: JC
authors.lastname: Prior
authors.forename: L
authors.initials: L
authors.lastname: Joseph
authors.forename: D A
authors.initials: DA
authors.lastname: Hanley
authors.forename: W P
authors.initials: WP
authors.lastname: Olszynski
authors.forename: T M
authors.initials: TM
authors.lastname: Murray
authors.forename: T
authors.initials: T
authors.lastname: Anastassiades
authors.forename: W
authors.initials: W
authors.lastname: Hopman
authors.forename: J P
authors.initials: JP
authors.lastname: Brown
authors.forename: S
authors.initials: S
authors.lastname: Kirkland
authors.forename: C
authors.initials: C
authors.lastname: Joyce
authors.forename: A
authors.initials: A
authors.lastname: Papaioannou
authors.forename: S
authors.initials: S
authors.lastname: Poliquin
authors.forename: A
authors.initials: A
authors.lastname: Tenenhouse
authors.forename: E A
authors.initials: EA
authors.lastname: Papadimitropoulos
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D050723:Fractures, Bone / Q000209:etiology* / Q000534:rehabilitation*; D006305:Health Status Indicators; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications*; D015663:Osteoporosis, Postmenopausal / Q000150:complications; D011788:Quality of Life