[Effect of nooglutil on rats with intracerebral posttraumatic hematoma (hemorrhagic stroke)].
The effect of the new nootropic drug nooglutyl, a positive modulator of AMPA-subtype glutamatergic receptors, was studied in rats with a model hemorrhagic stroke (HS)--posttraumatic hematoma induced by cerebral tissue destruction in the capsule interna region. Single intraperitoneal injections of nooglutyl (10 and 20 mg/kg) 3-4 h after operation decreased the HS-induced neurological deficiency, restored the coordination of movements, improved the passive avoidance reaction retrieval, and prevented the loss of experimental animals. The results show evidence of a pronounced neuroprotector action of nooglutyl in rats with the HS model.
Garibova
T L
TL
Laboratory of Psychopharmacology, Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Galaeva
I P
IP
Voronina
T A
TA
Kraĭneva
V A
VA
Kapitsa
I G
IG
Kirichenko
S V
SV
Makarenko
A N
AN
Mirzoian
G R
GR
Kuznetsova
E A
EA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D020202:Cerebral Hemorrhage, Traumatic / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D003213:Conditioning, Psychological / Q000187:drug effects; D005971:Glutamates / Q000627:therapeutic use*; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009539:Nicotinic Acids / Q000627:therapeutic use*; D051381:Rats
D005971:Glutamates; D018696:Neuroprotective Agents; D009539:Nicotinic Acids; C066295:nooglutil