Efficient radical scavenging ability of artepillin C, a major component of Brazilian propolis, and the mechanism.
Hydrogen transfer from artepillin C to cumylperoxyl radical proceeds via one-step hydrogen atom transfer rather than via electron transfer, the rate constant of which is comparable to that of (+)-catechin, indicating that artepillin C can act as an efficient antioxidant.
Nakanishi
Ikuo
I
Redox Regulation Research Group, Research Center for Radiation Safety, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555, Japan. nakanis@nirs.go.jp
Uto
Yoshihiro
Y
Ohkubo
Kei
K
Miyazaki
Kentaro
K
Yakumaru
Haruko
H
Urano
Shiro
S
Okuda
Haruhiro
H
Ueda
Jun-Ichi
J
Ozawa
Toshihiko
T
Fukuhara
Kiyoshi
K
Fukuzumi
Shunichi
S
Nagasawa
Hideko
H
Hori
Hitoshi
H
Ikota
Nobuo
N
D002392:Catechin / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D005609:Free Radicals / Q000037:antagonists & inhibitors / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D007700:Kinetics; D019384:Nucleic Acid Synthesis Inhibitors; D010545:Peroxides / Q000037:antagonists & inhibitors / Q000737:chemistry; D010666:Phenylpropionates / Q000737:chemistry* / Q000494:pharmacology*; D011429:Propolis / Q000737:chemistry*
D016166:Free Radical Scavengers; D005609:Free Radicals; D019384:Nucleic Acid Synthesis Inhibitors; D010545:Peroxides; D010666:Phenylpropionates; C049375:perhydroxyl radical; C102259:artepillin C; D006859:Hydrogen; D002392:Catechin; D011429:Propolis