title: Healthy children as subjects in pharmaceutical research.
abstract: Recruitment of healthy children for drug research has emerged due in part to several new American laws and policies that have led to a surge in pharmaceutical research involving children-subjects. In this paper, I review the ethical and scientific issues and the arguments in favor and against this new practice.
authors.affiliation: Division of Clinical Pharmacology and Toxicology, Toronto, ON, Canada. gkoren@sickkids.ca
authors.forename: Gideon
authors.initials: G
authors.lastname: Koren
mesh_terms: D002648:Child; D002986:Clinical Trials as Topic / Q000941:ethics*; D004341:Drug Evaluation / Q000941:ethics*; D015507:Drugs, Investigational; D028744:Ethics Committees, Research; D006801:Humans; D009042:Motivation; D033282:Parental Consent / Q000941:ethics; D018579:Patient Selection / Q000941:ethics*; D010372:Pediatrics / Q000941:ethics*; D014481:United States
chemical_list: D015507:Drugs, Investigational