Glycolaldehyde induces apoptosis in a human breast cancer cell line.
Activated phagocytes employ myeloperoxidase to generate glycolaldehyde, 2-hydroxypropanal, and acrolein. Because alpha-hydroxy and alpha,beta-unsaturated aldehydes are highly reactive, phagocyte-mediated formation of these products may play a role in killing bacteria and tumor cells. Using breast cancer cells, we demonstrate that glycolaldehyde inactivates glucose-6-phosphate dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, and Cu,Zn superoxide dismutase, suppresses cell growth, and induces apoptosis. These results suggest that glycolaldehyde might be an important mediator of neutrophil anti-tumor activity.
Al-Maghrebi
May A
MA
The Department of Biochemistry, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait.
Al-Mulla
Fahd
F
Benov
Ludmil T
LT
D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001943:Breast Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000378:metabolism; D024581:Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000378:metabolism; D006037:Glyoxal / Q000032:analysis; D006801:Humans; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000378:metabolism
D006037:Glyoxal; D005954:Glucosephosphate Dehydrogenase; D013482:Superoxide Dismutase; D024581:Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); D000079:Acetaldehyde