[Mechanism of nootropic digam action in hypofunction of brain dopaminergic system].
Using microchemical methods for detection of dopamine (DA), noradrenaline (NA), serotonin (S) and its metabolite--5'-hydroxyindolilacetic acid (5'-HIAA) as well as the activity of neuromediator-utilising enzymes--MAO A and B and enzymes of acetylcholine metabolism--cholinacetyltranspherase (ChAT) and acetylcholinesterase (AChE), we revealed that synthetic GABA-derivative compound diagram (250 mg/kg during 10 days) normalized functioning of dopaminergic and acetylcholinergic systems in sensormotor cortex and caudate nucleus of Wistar rats with haloperidol-induced (0.5 mg/kg during 30 days) bradykinesia. Measured by quantitative interpherometric method, a specific response of functionally different sensomotor cortex (layers III and V) neurons and caudate nucleus by such characteristics as cytoplasm and nuclei sizes, protein content and concentration was found. Control for rat's behavior in open field revealed that diagram restored emotional activity disturbed by haloperidol injections and improved the indices of the animals searching activity.
Gerstein
L M
LM
Dovedova
E L
EL
Popova
N S
NS
D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects* / Q000503:physiopathology; D018492:Dopamine Antagonists / Q000009:adverse effects; D018682:GABA Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006220:Haloperidol / Q000009:adverse effects; D018697:Nootropic Agents / Q000494:pharmacology / Q000627:therapeutic use; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology*
D018492:Dopamine Antagonists; D018682:GABA Agents; D018697:Nootropic Agents; C479872:digam; D005680:gamma-Aminobutyric Acid; D006220:Haloperidol