title: Do patients with a higher body mass index have a greater risk of advanced-stage renal cell carcinoma?
abstract: OBJECTIVE
  To evaluate whether patients with a higher body mass index (BMI) are at elevated risk of an advanced tumor stage for renal cell carcinoma at diagnosis. A high BMI has recently been proved to be associated with advanced tumor stages for some malignant diseases.
  
  
  METHODS
  From January 1994 to December 2000, 693 operations for renal cell carcinoma were performed in 683 patients at our institution. Ten patients underwent surgery twice for bilateral tumors. Of the 683 patients, 417 were men and 266 women. The mean age at surgery was 62.2 years, and the mean tumor diameter was 5.2 cm. Seventy-eight percent of the patients were asymptomatic at tumor diagnosis. The following parameters were evaluated with regard to a possible correlation to tumor stage and/or tumor diameter: BMI, presence of symptoms, age, sex, hemoglobin, lactate dehydrogenase, erythrocyte sedimentation rate, serum cholesterol, and triglycerides. For statistical analysis, the Spearman rank correlation test was used.
  
  
  RESULTS
  The mean BMI was 26.8 +/- 4.4 (range 16.9 to 44.3). Statistical analysis showed a significant positive correlation between advanced T stage and the presence of symptoms (P <0.0001), erythrocyte sedimentation rate (P <0.0001), lactate dehydrogenase (P = 0.0015), and age (P = 0.046), and an inverse correlation with hemoglobin (P <0.0001) and serum cholesterol (P <0.0001). For all other investigated parameters, including BMI, no significant correlation could be proved.
  
  
  CONCLUSIONS
  Our data indicate that obese patients are not at greater risk of advanced tumor stages of renal cell carcinoma at the time of diagnosis compared with a population of normal weight.
authors.affiliation: Department of Urology, University Hospital, Karl Franzens University Graz, Graz, Austria.
authors.forename: Luigi
authors.initials: L
authors.lastname: Schips
authors.forename: Richard
authors.initials: R
authors.lastname: Zigeuner
authors.forename: Katja
authors.initials: K
authors.lastname: Lipsky
authors.forename: Franz
authors.initials: F
authors.lastname: Quehenberger
authors.forename: Michael
authors.initials: M
authors.lastname: Salfellner
authors.forename: Susanne
authors.initials: S
authors.lastname: Winkler
authors.forename: Karl
authors.initials: K
authors.lastname: Pummer
authors.forename: Gerhart
authors.initials: G
authors.lastname: Hubmer
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002292:Carcinoma, Renal Cell / Q000453:epidemiology* / Q000473:pathology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009765:Obesity / Q000453:epidemiology*; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution