[Co-expression of TrkA and p75 neurotrophin receptor in extracranial olfactory neuroblastoma cells].
OBJECTIVE
To determine whether TrkA and p75 are expressed in olfactory neuroblastoma (ON) and whether the evaluation of their expression by immunohistochemistry is useful to predict the outcome of ON.


METHODS
Ten cases of ON and 5 nasopharyngeal carcinoma and 5 normal olfactory neuroepithelial of nasal cavity were examined for the expression of TrkA and p75 neurotrophin receptors using immunohistochemistry and double fluorescence labeling.


RESULTS
The 10 cases of ON showed positive immunohistochemical staining for both TrkA and p75. Double staining revealed that almost all TrkA immunoreactive ON cells also contained p75 immunoreactive. In contrast, no TrkA or p75 immunoreactivity was detected in nasopharyngeal cells and normal olfactory neuroepithelial cells.


CONCLUSIONS
Nerve growth factor may play a role in the generation of ON and staining of TrkA and p75 may assist diagnosis of ON.
Zhao
Su-ping
SP
Department of Otorhinolaryngology, Xiangya Hospital, Central South University, Changsha 410008, China.
D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor; D002648:Child; D018304:Esthesioneuroblastoma, Olfactory / Q000737:chemistry*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000737:chemistry*; D009669:Nose Neoplasms / Q000737:chemistry*; D020800:Receptor, Nerve Growth Factor / Q000032:analysis*; D020917:Receptor, trkA / Q000032:analysis*
D014408:Biomarkers, Tumor; D020800:Receptor, Nerve Growth Factor; D020917:Receptor, trkA