title: Diabetes mellitus adversely affects the outcomes of thrombolytic therapy in patients with acute myocardial infarction.
abstract: This study was performed to evaluate whether coexistent diabetes mellitus has any adverse effect on the outcomes of thrombolytic therapy in patients with acute myocardial infarction. Although the early reperfusion rates were similar between the two groups of patients who had acute myocardial infarction with and without diabetes mellitus (42% vs 45.4%, p > 0.05), the results of late angiographic examination showed a significantly lower rate of patency in infarct-related coronary artery (defined as TIMI 3 flow) in diabetics compared to nondiabetics (28.9% vs 41.3%, p < 0.001). The global left ventricular function was also poorer in diabetics (left ventricular wall motion score was 18.6 +/- 7.3 in diabetics and 14.1 +/- 4.6 in nondiabetics, p < 0.01).
authors.affiliation: University of Celal Bayar, Department of Cardiology, Manisa, Turkey. hakancant@superonline.com
authors.forename: Hakan
authors.initials: H
authors.lastname: Tikiz
authors.forename: Ugur
authors.initials: U
authors.lastname: Tezcan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ileri
authors.forename: Yücel
authors.initials: Y
authors.lastname: Balbay
authors.forename: Ramazan
authors.initials: R
authors.lastname: Atak
authors.forename: Emine
authors.initials: E
authors.lastname: Kütük
mesh_terms: D009202:Cardiomyopathies / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D003097:Collateral Circulation / Q000502:physiology; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013300:Streptokinase / Q000627:therapeutic use*; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase; D010959:Tissue Plasminogen Activator