Comparison of three different purification methods for the routine preparation of [11C] Metomidate.
PET with (R)-[O-methyl-11C] metomidate ([11C] MTO) is an attractive method for the characterisation of adrenal masses discriminating lesions of adrenal cortical origin from noncortical lesions. [11C] MTO was prepared by the reaction of [11C] methyliodide with the corresponding free acid. Three purification methods have been compared. The method of choice uses preparative HPLC with a ready-to-use weak acidic solvent.
Mitterhauser
Markus
M
Department of Nuclear Medicine, University of Vienna, AKH Wein, Waehringer Guertel 18-20, 1090 Vienna, Austria. markus.mitterhauser@akh-wien.ac.at
Wadsak
Wolfgang
W
Langer
Oliver
O
Schmaljohann
Joern
J
Zettinig
Georg
G
Dudczak
Robert
R
Viernstein
Helmut
H
Kletter
Kurt
K
D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging; D002250:Carbon Radioisotopes / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D005045:Etomidate / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000302:isolation & purification*; D007553:Isotope Labeling / Q000379:methods*; D011786:Quality Control; D014055:Tomography, Emission-Computed / Q000379:methods*
D002250:Carbon Radioisotopes; C084586:metomidate; D005045:Etomidate