title: Patient with Kabuki syndrome and acute leukemia.
abstract: Kabuki syndrome is a multiple congenital anomaly/mental retardation syndrome which often involves recurrent infections. There is cumulative evidence of an immunodeficiency in Kabuki patients. We report a 2-year-old girl with typical Kabuki syndrome, who developed acute lymphocytic leukemia. The patient showed low levels of immunoglobulins G and A and a history of recurrent infections, that might indicate an immunodeficiency leading to an increased susceptibility to cancer. The girl was treated according to BFM protocols adapted to the patient's impaired cardiac situation and severe underweight. She achieved continual complete remission. Classical and molecular cytogenetic analyzes did not detect any abnormality.
authors.affiliation: Children's Hospital Kemperhof, Koblenz, Germany. schrerhs@t-online.de
authors.forename: Sabine
authors.initials: S
authors.lastname: Scherer
authors.forename: Ursel
authors.initials: U
authors.lastname: Theile
authors.forename: Vera
authors.initials: V
authors.lastname: Beyer
authors.forename: Rudolf
authors.initials: R
authors.lastname: Ferrari
authors.forename: Christiane
authors.initials: C
authors.lastname: Kreck
authors.forename: Manfred
authors.initials: M
authors.lastname: Rister
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000235:genetics / Q000503:physiopathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000503:physiopathology*