Capture of Ni(II), Cu(I) and Z(II) by thiolate sulfurs of an N2S2Ni complex: a role for a metallothiolate ligand in the acetyl-coenzyme A synthase active site.
The metal binding affinity of an (N2S2)Ni bridging metallothiolate ligand (Zn2+ < Ni2+ < Cu+) gives precedent for the observed heterogeneity in ACS/CODH.
Golden
Melissa L
ML
Texas A&M University, Department of Chemistry, College Station, Texas, USA.
Rampersad
Marilyn V
MV
Reibenspies
Joseph H
JH
Darensbourg
Marcetta Y
MY
D000106:Acetate-CoA Ligase / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D003300:Copper / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D019216:Metals, Heavy / Q000737:chemistry* / Q000378:metabolism; D008956:Models, Chemical; D009532:Nickel / Q000737:chemistry / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry; D010084:Oxidation-Reduction; D013455:Sulfur / Q000737:chemistry* / Q000378:metabolism; D015032:Zinc / Q000737:chemistry / Q000378:metabolism
D008024:Ligands; D019216:Metals, Heavy; D009942:Organometallic Compounds; D013455:Sulfur; D003300:Copper; D009532:Nickel; D000106:Acetate-CoA Ligase; D015032:Zinc