Promoter hypermethylation in cancer silences LDHB, eliminating lactate dehydrogenase isoenzymes 1-4.
Maekawa
Masato
M
Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan. mmaekawa@hama-med.ac.jp
Taniguchi
Terumi
T
Ishikawa
Jinko
J
Sugimura
Haruhiko
H
Sugano
Kokichi
K
Kanno
Takashi
T
D015179:Colorectal Neoplasms / Q000201:enzymology / Q000378:metabolism; D019175:DNA Methylation; D020868:Gene Silencing; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D018807:Polymorphism, Single-Stranded Conformational; D011401:Promoter Regions, Genetic; D021122:Protein Subunits / Q000235:genetics; D013274:Stomach Neoplasms / Q000201:enzymology / Q000378:metabolism; D014407:Tumor Cells, Cultured
D007527:Isoenzymes; D021122:Protein Subunits; D007770:L-Lactate Dehydrogenase; C409676:lactate dehydrogenase 2; C409677:lactate dehydrogenase 3; C409678:lactate dehydrogenase 4; C409667:lactate dehydrogenase 1