title: Neonatal craniopharyngioma and inference of tumor inception time: case report and review of the literature.
abstract: BACKGROUND
  Craniopharyngioma is a rare neonatal tumor, although it is the most common tumor of the parasellar region in childhood. Only a few cases have been antenatally diagnosed. We report a case of neonatal craniopharyngioma surgically treated after birth and its inferred tumor inception time.
  
  
  METHODS
  A routine ultrasound at 33 weeks of gestation revealed a high echoic mass at the center of the head in this fetus. The baby was delivered normally at 40 weeks with no abnormal appearance of its body surface. Hypotonicity of her lower limbs was observed. The tumor was totally removed uneventfully by an interhemispheric trans-lamina-terminalis approach at 8 months after birth.
  
  
  CONCLUSIONS
  A kinetic study of the tumor showed that tumor inception time was on the 45.6th day of gestation. The present case is the fourth successful resection of neonatal craniopharyngioma. The literature is reviewed.
authors.affiliation: Department of Neurosurgery, Tokyo Metropolitan Hospital, Tokyo, Japan.
authors.forename: Toshinari
authors.initials: T
authors.lastname: Arai
authors.forename: K
authors.initials: K
authors.lastname: Ohno
authors.forename: Y
authors.initials: Y
authors.lastname: Takada
authors.forename: M
authors.initials: M
authors.lastname: Aoyagi
authors.forename: K
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D003397:Craniopharyngioma / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016216:Ultrasonography, Prenatal