A novel 5-HT receptor ligand and related cytotoxic compounds from an acid mine waste extremophile.
Berkeley Pit Lake in Butte, Montana, is an acid mine waste reservoir rich in toxic metals. A Pithomycessp. isolated from the Pit Lake yielded three tyrosine derivatives (1-3), one of which acts as a 5-HT((2a)) receptor ligand. This type of activity has been associated with migraine preventative and antihypertensive drugs. The isolation and characterization of compounds 1-3 and three sesquiterpenes (5-7) that have been isolated previously from higher plants are reported here.
Stierle
Andrea A
AA
Department of Chemistry, Montana Tech of The University of Montana, Butte, Montana 59701, USA. astierle@mtech.edu
Stierle
Donald B
DB
Goldstein
Eric
E
Parker
Keith
K
Bugni
Tim
T
Baarson
Chad
C
Gress
Julie
J
Blake
Danielle
D
D000818:Animals; D005658:Fungi / Q000737:chemistry; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009009:Montana; D041681:NIH 3T3 Cells / Q000187:drug effects; D051381:Rats; D044402:Receptor, Serotonin, 5-HT2A / Q000187:drug effects*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014443:Tyrosine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D014866:Waste Products / Q000032:analysis*; D014867:Water / Q000032:analysis*
D008024:Ligands; D044402:Receptor, Serotonin, 5-HT2A; D012717:Sesquiterpenes; D014866:Waste Products; D014867:Water; D014443:Tyrosine