title: [2-(2'-hydroxy 2'-substituted) ethyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazines--a novel group of substances with anti-arrhythmia activity].
abstract: The antiarrhythmic activity and acute toxicity of a series of 2-(2'-hydroxy-2'-substituted) ethyl-1,2,3,4-tetrahydropyrrolo[1,2- a]pyrazines were studied. Two most promising compounds (PV-168 PV-174) are characterized by a high antiarrhythmic activity, a broad spectrum of action, and low toxicity.
authors.affiliation: Pharmacology Department, Voronezh State Medical Academy, ul. Studencheskya 10, Voronezh, 394000 Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Filippova
authors.forename: S A
authors.initials: SA
authors.lastname: Kryzhanovskiĭ
authors.forename: V P
authors.initials: VP
authors.lastname: Peresada
authors.forename: A M
authors.initials: AM
authors.lastname: Likhosherstov
authors.forename: M B
authors.initials: MB
authors.lastname: Vititnova
authors.forename: N V
authors.initials: NV
authors.lastname: Kaverina
authors.forename: K M
authors.initials: KM
authors.lastname: Reznikov
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000401:mortality; D005260:Female; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D023382:Toxicity Tests, Acute
chemical_list: D000889:Anti-Arrhythmia Agents; D011758:Pyrroles