Frequent gains of 20q and losses of 18q are associated with lymph node metastasis in intestinal-type gastric cancer.
BACKGROUND
The genetic aberrations associated with development and progression of gastric carcinomas (GCs) are poorly understood. The aim of this study was to identify chromosomal aberrations associated with the development and/or progression of intestinal-type GC.


METHODS
Comparative genomic hybridization (CGH) analysis was applied to 36 intestinal-type GCs. We compared chromosomal aberrations detected by CGH analysis with clinicopathological parameters.


RESULTS
Frequent gains of DNA copy number were found on 8q, 13q, 20q, 3q, 6q and losses were found on 17p, 18q in intestinal-type GCs. No significant differences were observed in the chromosomal aberrations between tumor stage, tumor location, peritoneal dissemination, liver metastasis or other distant metastasis. However, the frequencies of 20q12-13 gain and 18q21-22 loss were significantly higher in tumors with lymph node metastasis than in those without metastasis.


CONCLUSIONS
Gains of 20q and losses of 18q may contribute to lymph node metastasis and the malignant phenotype in intestinal-type GCs.
Hidaka
Shigekazu
S
Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto Machi, Nagasaki City, Nagasaki 852-8501, Japan. hidaka-s@net.nagasaki-u.ac.jp
Yasutake
Toru
T
Kondo
Masamichi
M
Takeshita
Hiroak
H
Yano
Hiroshi
H
Haseba
Masatoshi
M
Tsuji
Takashi
T
Sawai
Terumitsu
T
Nakagoe
Tohru
T
Tagawa
Yutaka
Y
D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D018450:Disease Progression; D006801:Humans; D008207:Lymphatic Metastasis; D009693:Nucleic Acid Hybridization; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*
D004273:DNA, Neoplasm