Expression of p73 and c-Abl proteins in human ovarian carcinomas.
The p73, a homologue of the p53 tumor suppressor protein, has a pro-apoptotic activity which is induced by the c-Abl, a protein tyrosine kinase appearing in the nucleus and cytoplasm of proliferating cells. However, the role of p73 and c-Abl in ovarian cancer is not well-defined. We investigated immunohistochemical expressions of p73 and c-Abl in 64 ovarian carcinomas, 13 borderline and 14 benign ovarian tumors to elucidate their clinicopathological relevances. Of the malignant, borderline, and benign ovarian tumors, respectively, 33 (51%), 10 (77%) and 13 (93%) had negative or low p73 expression, 31 (48%), 3 (23%) and 1 (7%) had high p73 expression, 23 (36%), 5 (38%) and 10 (71%) had negative or low c-Abl expression, and 41 (64%), 8 (61%) and 4 (29%) had high c-Abl expression. A high p73 or c-Abl expression was significantly associated with ovarian carcinomas as compared to benign tumors (p=0.003 and p=0.03 respectively). In addition, a significant correlation was found between the high p73 expression and disease stage (p=0.04) and patient's survival (p=0.02). No correlation was found with c-Abl expression. These results reveal an association of p73 overexpression with advanced ovarian carcinomas which may suggest the p73 overexpression as an indicator of poor prognosis.
Niyazi
Maynur
M
The Department of Obstetrics and Gynecology, Nippon Medical School, Kawasaki, Kanagawa, Japan.
Ghazizadeh
Mohammad
M
Konishi
Hideki
H
Kawanami
Oichi
O
Sugisaki
Yuichi
Y
Araki
Tsutomu
T
D014408:Biomarkers, Tumor / Q000032:analysis; D004268:DNA-Binding Proteins / Q000032:analysis*; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D007150:Immunohistochemistry; D009687:Nuclear Proteins / Q000032:analysis*; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000401:mortality; D011379:Prognosis; D016315:Proto-Oncogene Proteins c-abl / Q000032:analysis*; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins
D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins; D016315:Proto-Oncogene Proteins c-abl