title: Gene expression profile of normal lungs predicts genetic predisposition to lung cancer in mice.
abstract: Genetic susceptibility to lung tumorigenesis shows large variations among mouse strains. To test whether genetic predisposition to lung tumorigenesis is associated with a specific gene expression profile in normal lungs, we analyzed gene expression in 16 inbred strains of known susceptibility/resistance to lung tumorigenesis, using the RIKEN mouse full-length cDNA 19K microarray set. The strain-specific expression profile of 91 cDNA clones correlated with strain lung tumor susceptibility/resistance and predicted, by principal component analysis, the genetic predisposition to lung tumorigenesis in mice.
authors.affiliation: Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Gariboldi
authors.forename: Monica
authors.initials: M
authors.lastname: Spinola
authors.forename: Silvano
authors.initials: S
authors.lastname: Milani
authors.forename: Carmen
authors.initials: C
authors.lastname: Pignatiello
authors.forename: Koji
authors.initials: K
authors.lastname: Kadota
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Bono
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Hayashizaki
authors.forename: Tommaso A
authors.initials: TA
authors.lastname: Dragani
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okazaki
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D017931:DNA Primers; D018076:DNA, Complementary; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity; D014158:Transcription, Genetic
chemical_list: D017931:DNA Primers; D018076:DNA, Complementary