title: Gene therapy of hepatocarcinoma: a long way from the concept to the therapeutical impact.
abstract: Hepatocellular carcinoma (HCC), the most prevalent histological form of primary liver cancer is one of the most frequent cancer worldwide. This pathology still requires the development of new therapeutical approaches. Gene therapy strategies focusing on the genetic manipulation of accessory cells involved in the immune reaction against cancer cells, or on the direct transduction of tumor cells with transgenes able to "suicide" cancer cells have been largely developed for more than ten years.
authors.affiliation: Département de thérapie cellulaire et génique, EFS Alpes Méditerranée, Marseille, France.
authors.forename: René
authors.initials: R
authors.lastname: Gérolami
authors.forename: Rathviro
authors.initials: R
authors.lastname: Uch
authors.forename: Christian
authors.initials: C
authors.lastname: Bréchot
authors.forename: Patrice
authors.initials: P
authors.lastname: Mannoni
authors.forename: Claude
authors.initials: C
authors.lastname: Bagnis
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D015316:Genetic Therapy / Q000639:trends; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D019076:Transgenes / Q000235:genetics