title: A new sesquiterpene hydroperoxide from the aerial parts of Aster oharai.
abstract: Phytochemical works on the aerial parts of Aster oharai (Compositae) led to the isolation of a new sesquiterpene hydroperoxide, 7alpha-hydroperoxy-3,11-eudesmadiene (2) and seven known compounds, teucdiol B (1), alpha-spinasterol (3), oleanolic acid (4), alpha-spinasterol 3-O-beta-D-glucopyranoside (5), methyl 3,5-di-O-caffeoyl quinate (6), 3,5-di-O-caffeoylquinic acid (7), 3,4-di-O-caffeoylquinic acid (8). The chemical structures of 1-8 were established by chemical and spectroscopic methods. Compound 2 showed cytotoxicity against cultured human tumor cell lines in vitro, SK-OV-3 (ovarian), SK-MEL-2 (skin melanoma), and HCT15 (colon) with ED50 values ranging from 3.86-17.21 microg/mL.
authors.affiliation: Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, Suwon, Kyunggi-Do 440-746, Korea.
authors.forename: Sang Zin
authors.initials: SZ
authors.lastname: Choi
authors.forename: Sung Ok
authors.initials: SO
authors.lastname: Lee
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D031173:Aster Plant; D045744:Cell Line, Tumor; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis* / Q000737:chemistry / Q000633:toxicity; D035261:Plant Components, Aerial / Q000633:toxicity; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000633:toxicity; D012717:Sesquiterpenes / Q000032:analysis* / Q000737:chemistry / Q000633:toxicity
chemical_list: D010936:Plant Extracts; D012717:Sesquiterpenes; D006861:Hydrogen Peroxide