title: Low blood glutathione levels in acute myocardial infarction.
abstract: BACKGROUND
  Although experimental studies have demonstrated that reduced glutathione (GSH) is involved in cellular protection from deleterious effects of oxygen free radicals in ischaemia and reperfusion, there are controversial data on the correlation between levels of GSH and the ischaemic process.
  
  
  OBJECTIVE
  The present study was planned to evaluate erythrocyte GSH levels in patients with acute myocardial infarction (AMI).
  
  
  METHODS
  Erythrocyte GSH levels were determined in 22 patients with AMI and 15 age matched healthy volunteers served as control.
  
  
  METHODS
  Erythrocyte GSH levels were measured by using Bentler in AMI and control patients. Also lipid profile was analyzed enzymatically in these subject.
  
  
  METHODS
  The values were expressed as means +/- standard deviation (SD) and data from patients and controls was compared using student's 't'-test.
  
  
  CONCLUSIONS
  GSH levels were significantly decreased in AMI as compared to control (p<0.001). Also, total cholesterol and triglycerides were higher is AMI subjects (p<0.05). These finding suggest that depressed GSH levels may be associated with enhanced protective mechanism to oxidative stress in AMI.
authors.affiliation: Department of Biochemistry, Pt. B.D. Sharma PGIMS, Rohtak, Haryana. simmikh@rediffmail.com
authors.forename: Simmi
authors.initials: S
authors.lastname: Kharb
mesh_terms: D015415:Biomarkers; D002784:Cholesterol / Q000097:blood; D005978:Glutathione / Q000097:blood*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009203:Myocardial Infarction / Q000097:blood*; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D014280:Triglycerides; D008315:Malondialdehyde; D002784:Cholesterol; D005978:Glutathione