title: Reliability of perioperative SSEP recordings in spine surgery.
abstract: OBJECTIVE
  The reproducibility and clinical reliability of perioperative somatosensory-evoked potentials (SSEP) were prospectively evaluated in uneventful scoliosis surgery. The influence of anesthesia owing to induction of total intravenous anesthesia (TIVA) upon preoperative SSEP and the variability of intraoperative SSEP were calculated. The potential effect of spine surgery was assessed by comparing pre- to postoperative SSEP.
  
  
  METHODS
  A total of 2,143 pre-, intra- and postoperative tibial and median SSEP recorded in 25 patients undergoing spine surgery owing to idiopathic scoliosis were analyzed. The anesthesia protocol consisted of a computerized target controlled infusion (TCI) device for propofol and intravenous application of an opioid.
  
  
  RESULTS
  Anesthesia induced a significant and comparable prolongation of the tibial SSEP onset, P40 and P60 latencies, while the N50 latency was less changed. Throughout anesthesia, latencies of median (onset, N20, P25 and N35) and tibial (onset, P40, N50 and P60) SSEP showed mean variations of less than 6%. The intraoperative SSEP amplitudes were less stable with a relative standard deviation of 30-40%. In uneventful spine surgery, the postoperative tibial SSEP were not significantly changed in comparison to preoperative recordings.
  
  
  CONCLUSIONS
  By using a standardized anesthesia protocol, the impact of anesthesia on preoperative SSEP can be predicted. Furthermore, the controlled application of sedatives and analgesics allows recording of stable SSEP parameters for intraoperative monitoring purposes. As in uneventful spine surgery pre- to postoperative SSEP are unchanged the latter comparison can be applied as an additional perioperative neuromonitoring procedure to assess the influence of spine surgery or other invasive interventions on spinal cord function.
authors.affiliation: ParaCare Balgrist, University Hospital Balgrist, University of Zürich, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Strahm
authors.forename: K
authors.initials: K
authors.lastname: Min
authors.forename: N
authors.initials: N
authors.lastname: Boos
authors.forename: Y
authors.initials: Y
authors.lastname: Ruetsch
authors.forename: A
authors.initials: A
authors.lastname: Curt
mesh_terms: D000293:Adolescent; D000328:Adult; D000777:Anesthetics / Q000494:pharmacology; D002648:Child; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D019635:Neurosurgical Procedures / Q000379:methods; D011446:Prospective Studies; D011930:Reaction Time; D015203:Reproducibility of Results; D012600:Scoliosis / Q000503:physiopathology* / Q000601:surgery*; D025321:Surgery, Computer-Assisted
chemical_list: D000777:Anesthetics