[Biologic function of p21WAF1/CIP1 gene and its association with carcinogenesis].
p21WAF1/CIP1 gene is known for a most important cell cycle regulator as well as its roles in appoptosis and differentiation. This review focuses on p21WAF1/CIP1 gene functions and its association with carcinogenesis. Better understanding of the structure and function of p21WAF1/CIP1 gene may help to comprehend molecular mechanisms of cancers and to facilitate diagnosis and treatment of malignancy.
Xi
Yaguang
Y
Peking University School of Oncology, Department of Genetic, Beijing Institute for Cancer Research, Beijing 100034, China.
Ren
Yinghui
Y
Su
Xiulan
X
Ke
Yang
Y
D063646:Carcinogenesis; D002454:Cell Differentiation; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000235:genetics*; D006801:Humans
C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21