title: Free latissimus dorsi flap used in treatment of cerebral aspergillosis: a case report and review of the literature.
abstract: Cerebral aspergillosis infection is a rare disease in children that carries extremely high morbidity and mortality. Although occurring most commonly in the immunosuppressed patient, cerebral aspergillosis infection has been reported after trauma or neurosurgical procedures. Amphotericin B is the main medical therapy for cerebral aspergillosis. However, surgical treatment is often required for cases of abscess or granuloma formation. Despite aggressive antifungal treatment and surgical intervention, aspergillosis of the central nervous system is often fatal. We present a case report in which a free latissimus dorsi muscle flap was used in conjunction with antifungal medication and surgical debridement to treat intracranial and epidural aspergillosis in a young male following complex craniofacial trauma.
authors.affiliation: Division of Plastic Surgery, Lucile Salter Packard Children's Hospital and Stanford University Medical Center, Stanford, CA94305, USA.
authors.forename: Anuja K
authors.initials: AK
authors.lastname: Antony
authors.forename: Roy W
authors.initials: RW
authors.lastname: Hong
authors.forename: Manuel
authors.initials: M
authors.lastname: Amieva
authors.forename: Michael S
authors.initials: MS
authors.lastname: Taekman
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Huhn
authors.forename: Yvonne L
authors.initials: YL
authors.lastname: Karanas
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000601:surgery*; D001927:Brain Diseases / Q000188:drug therapy / Q000601:surgery*; D002648:Child; D003646:Debridement; D006801:Humans; D008297:Male; D013524:Surgical Flaps; D014946:Wound Infection / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery*
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B