Microdosimetric spectra of the THOR neutron beam for boron neutron capture therapy.
A primary objective of the BNCT project in Taiwan, involving THOR (Tsing Hua Open Pool Reactor), was to examine the potential treatment of hepatoma. To characterise the epithermal neutron beam in THOR, the microdosimetry distributions in lineal energy were determined using paired tissue-equivalent proportional counters with and without boron microfoils. Microdosimetry results were obtained in free-air and at various depths in a PMMA phantom near the exit of the beam port. A biological weighting function, dependent on lineal energy, was used to estimate the relative biological effectiveness of the beam. An effective RBE of 2.7 was found at several depths in the phantom.
Hsu
F Y
FY
Department of Nuclear Science, National Tsing Hua University, Hsinchu 300, Taiwan.
Tung
C J
CJ
Watt
D E
DE
D000465:Algorithms; D001822:Body Burden; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D018499:Linear Energy Transfer; D009502:Neutrons / Q000627:therapeutic use; D009688:Nuclear Reactors; D019047:Phantoms, Imaging; D011829:Radiation Dosage; D011835:Radiation Protection / Q000295:instrumentation* / Q000379:methods*; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation* / Q000379:methods*; D012062:Relative Biological Effectiveness; D012098:Reproduction; D012680:Sensitivity and Specificity