title: Gadobutrol-enhanced moving-table magnetic resonance angiography in patients with peripheral vascular disease: a prospective, multi-centre blinded comparison with digital subtraction angiography.
abstract: The purpose of this study was to compare moving-table three-dimensional contrast-enhanced magnetic resonance angiography (CE MRA), using 1.0-mol gadobutrol, with intra-arterial digital subtraction angiography (i.a. DSA) for evaluation of pelvic and peripheral arteries in patients with peripheral arterial occlusive disease. A total of 203 patients were examined in a prospective, multi-centre study at 1.0/1.5 T. Ten vessel segments of one leg were evaluated on-site and by three independent blinded reviewers off-site. One hundred eighty-two patients were evaluable in blinded reading. For pelvis and thigh, there was statistically significant diagnostic agreement between CE MRA and i.a. DSA on-site (94%) and off-site (86-88%). Overall, for detection of clinically significant stenoses, 93% sensitivity and 90% specificity were achieved in on-site evaluation, with 71-76 and 87-93% off-site; for detection of occlusion, sensitivity and specificity on-site were 91 and 97%, with 75-82 and 94-98% off-site. Evaluation was more sensitive on-site than off-site for detection of stenoses and occlusion, whereas specificity was similar. The CE MRA with 1.0-mol gadobutrol gave results comparable to those of i.a. DSA for the larger arteries of pelvis and thigh. Results for calf arteries were compromised by spatial resolution and technical limitations.
authors.affiliation: Schering AG, Berlin, Germany. ashentsch@aol.com
authors.forename: Annette
authors.initials: A
authors.lastname: Hentsch
authors.forename: Manuela A
authors.initials: MA
authors.lastname: Aschauer
authors.forename: Jörn O
authors.initials: JO
authors.lastname: Balzer
authors.forename: Joachim
authors.initials: J
authors.lastname: Brossmann
authors.forename: Hans P
authors.initials: HP
authors.lastname: Busch
authors.forename: Kirsten
authors.initials: K
authors.lastname: Davis
authors.forename: Philippe
authors.initials: P
authors.lastname: Douek
authors.forename: Franz
authors.initials: F
authors.lastname: Ebner
authors.forename: Jos M A
authors.initials: JM
authors.lastname: van Engelshoven
authors.forename: Michaela
authors.initials: M
authors.lastname: Gregor
authors.forename: Christian
authors.initials: C
authors.lastname: Kersting
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Knüsel
authors.forename: Edward
authors.initials: E
authors.lastname: Leen
authors.forename: Tim
authors.initials: T
authors.lastname: Leiner
authors.forename: Christian
authors.initials: C
authors.lastname: Loewe
authors.forename: Simon
authors.initials: S
authors.lastname: McPherson
authors.forename: Peter
authors.initials: P
authors.lastname: Reimer
authors.forename: Fritz K W
authors.initials: FK
authors.lastname: Schäfer
authors.forename: Matthias
authors.initials: M
authors.lastname: Taupitz
authors.forename: Siegfried A
authors.initials: SA
authors.lastname: Thurnher
authors.forename: Bernd
authors.initials: B
authors.lastname: Tombach
authors.forename: Robin
authors.initials: R
authors.lastname: Wegener
authors.forename: Dominik
authors.initials: D
authors.lastname: Weishaupt
authors.forename: James F M
authors.initials: JF
authors.lastname: Meaney
mesh_terms: D015901:Angiography, Digital Subtraction; D001157:Arterial Occlusive Diseases / Q000175:diagnosis*; D003287:Contrast Media; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007866:Leg / Q000098:blood supply; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010388:Pelvis / Q000098:blood supply; D016491:Peripheral Vascular Diseases / Q000175:diagnosis*; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C090600:gadobutrol