[Effect of chronic ethanol consumption on basic carboxypeptidase activity in regions of the rat brain].
It is discovered that chronic consumption of ethanol induced decrease of carboxypeptidase H activity in striatum by 27%; increase of carboxypeptidase M activity in hippocampus by 67% and decrease in cerebral hemispheres by 34%; phenylmethylsulfonyl fluoride-inhibited carboxypeptidase activity increase in hypothalamus by 141%, in striatum by 60% and in optic and lamina quadrigemina by 34%. The role of basic carboxypeptidases in mechanisms of ethanol influence on the peptidergic systems are discussed.
Vernigora
A  N
A
Penza State Pedagogical University, Russia.
Mikhaĭlova
O E
OE
Gengin
M T
MT
Ryzhkova
Iu A
IuA
Mukhina
E S
ES
D000428:Alcohol Drinking / Q000009:adverse effects*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D043423:Carboxypeptidase H / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D000431:Ethanol / Q000633:toxicity*; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology; D007031:Hypothalamus / Q000187:drug effects / Q000201:enzymology; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology; D051381:Rats; D013687:Telencephalon / Q000187:drug effects / Q000201:enzymology
D004791:Enzyme Inhibitors; D000431:Ethanol; D010664:Phenylmethylsulfonyl Fluoride; D043423:Carboxypeptidase H