Effects of hormone replacement therapy on platelet activation in postmenopausal women.
OBJECTIVE
To assess the effects of hormone replacement therapy (HRT) on platelet activation in postmenopausal women compared with premenopausal women.


METHODS
The expressions of CD41 and CD62P in fifteen postmenopausal women before and after HRT were detected using flow cytometry (FCM), with fifteen premenopausal women with a mean age of 47 years as controls.


RESULTS
The expressions of CD41 and CD62P in postmenopausal women were higher than those in the control group. CD62P(%), CD62P(I) and CD41 were reduced from 36.40 +/- 5.9, 37.75 +/- 5.8, and 470.11 +/- 74.0 to 27.97 +/- 5.6, 26.64 +/- 4.9, and 303.23 +/- 72.8 after six months of HRT (P < 0.05).


CONCLUSIONS
Platelet activation in postmenopausal women was higher than in premenopausal women and was reduced significantly after six months of HRT. HRT may have a favorable effect on reduction of platelet activity.
Gu
Jian
J
Department of Obstetrics and Gynecology, Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China. doctorguj@yahoo.com.cn
Yang
Dongzi
D
Wang
Liang'an
L
Yin
Songmei
S
Kuang
Jianquan
J
D000328:Adult; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008875:Middle Aged; D015539:Platelet Activation / Q000187:drug effects*; D017698:Postmenopause / Q000502:physiology*