A case of antiphospholipid syndrome with cutaneous ulcer and intrauterine fetal growth retardation.
A 28-year-old patient presented with severe intrauterine fetal growth retardation (IUGR) at 34 weeks' gestation. There was a prior history of a recurrent cutaneous ulcer on the left thigh. Serological tests for IgG anticardiolipin antibody were positive. A live premature male infant was delivered by an urgent cesarean section because of fetal distress. Histopathological examination revealed that the causes of the cutaneous ulcer and IUGR were thrombosis of the small blood vessels and placental infarction, respectively. Early diagnosis and proper treatment are important in the management of the antiphospholipid syndrome.
Nakano
Junji
J
Department of Dermatology, Tokuyama Central Hospital, Tokuyama, Japan.
Nakamura
Mitsutaka
M
Ito
Takehisa
T
Murata
Masako
M
Fujiyama
Jun-Ichi
J
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000473:pathology*; D001707:Biopsy, Needle; D002585:Cesarean Section; D005260:Female; D005317:Fetal Growth Retardation / Q000150:complications / Q000473:pathology*; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011256:Pregnancy Outcome; D018570:Risk Assessment; D012883:Skin Ulcer / Q000150:complications / Q000473:pathology*