title: Structure-activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone).
abstract: This paper describes the discovery of a novel free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone, 1), as a potent antioxidant agent against lipid peroxidation. The structure-activity relationship of edaravone indicated that lipophilic substituents were essential to show its lipid peroxidation-inhibitory activity. In vivo studies revealed that edaravone showed brain-protective activity in a transient ischemia model.
authors.affiliation: Research and Development Division, Mitsubishi Pharma Corporation, Yokohama, Japan. Watanabe.Kazutoshi@mb.m-pharma.co.jp
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Watanabe
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Morinaka
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Iseki
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Watanabe
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yuki
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Nishi
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology*; D000077553:Edaravone; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine