title: HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women.
abstract: Incidence of cervical cancer is high among Bolivian Andean women. Human papillomavirus (HPV) infection is known as the major risk factor of cervical cancer. The host immune system plays an important role in the outcome of HPV infection and associated malignancies. In order to study the immunogenetic background of Bolivian Andean women with regard to HPV infection status, we compared HLA class I and class II allele frequencies between 37 HPV positive and 68 HPV negative Bolivian women. Demographic variables, including distribution of Andean ethnicities, were similar in both groups. Comparison of HLA class I allele frequencies between both groups indicated no significant difference. In contrast, HLA class II DRB1*1602 allele, an Amerindian allele, was significantly higher in the HPV positive women compared with HPV negative controls (chi(2) = 5.2, p < 0.05, odds ratio = 3.17; 95% confidence interval = 1.4-8.8). HPV types present in the HPV positive group were HPV-18, -16, -31, -33, and -58. These results suggest that HLA class II DRB1*1602 may confer susceptibility to infection with genetically related HPV types. This is the first report of an HLA class II association with HPV infection in an Andean population.
authors.affiliation: Department of Virology, Kagoshima University, Kagoshima, Japan.
authors.forename: Jorge
authors.initials: J
authors.lastname: Cervantes
authors.forename: Carolina
authors.initials: C
authors.lastname: Lema
authors.forename: Luisa
authors.initials: L
authors.lastname: Valentina Hurtado
authors.forename: Ronald
authors.initials: R
authors.lastname: Andrade
authors.forename: Luis
authors.initials: L
authors.lastname: Hurtado Gomez
authors.forename: Lorena
authors.initials: L
authors.lastname: Torrico
authors.forename: Lourdes
authors.initials: L
authors.lastname: Zegarra
authors.forename: Gladys
authors.initials: G
authors.lastname: Quiroga
authors.forename: David
authors.initials: D
authors.lastname: Asturizaga
authors.forename: Alfredo
authors.initials: A
authors.lastname: Dulon
authors.forename: Raul
authors.initials: R
authors.lastname: Prada
authors.forename: Wilge
authors.initials: W
authors.lastname: Panoso
authors.forename: Shinji
authors.initials: S
authors.lastname: Yashiki
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Fujiyoshi
authors.forename: Shunro
authors.initials: S
authors.lastname: Sonoda
mesh_terms: D000293:Adolescent; D000328:Adult; D001838:Bolivia; D003710:Demography; D005260:Female; D005787:Gene Frequency; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000821:virology*
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II