title: Neonatologists are using much less dexamethasone.
abstract: Two historical cohorts (1993-1994 and 2001) of preterm infants ventilated for respiratory distress syndrome were compared. Dexamethasone administration fell from 22% to 6%. Chronic lung disease in survivors rose slightly from 13% to 17%, and mortality fell from 21% to 15% (other causes). The effect of restriction of dexamethasone use on chronic lung disease and mortality remains to be seen.
authors.affiliation: Kaplan Medical Center, Rehovot, Israel. Soroka Medical Center, Beersheva, Israel. eric_w@clalit.org.il
authors.forename: E S
authors.initials: ES
authors.lastname: Shinwell
authors.forename: M
authors.initials: M
authors.lastname: Karplus
authors.forename: D
authors.initials: D
authors.lastname: Bader
authors.forename: S
authors.initials: S
authors.lastname: Dollberg
authors.forename: I
authors.initials: I
authors.lastname: Gur
authors.forename: Z
authors.initials: Z
authors.lastname: Weintraub
authors.forename: S
authors.initials: S
authors.lastname: Arnon
authors.forename: E
authors.initials: E
authors.lastname: Gottfreid
authors.forename: A
authors.initials: A
authors.lastname: Zaritsky
authors.forename: I R
authors.initials: IR
authors.lastname: Makhoul
authors.forename: D
authors.initials: D
authors.lastname: Reich
authors.forename: L
authors.initials: L
authors.lastname: Sirota
authors.forename: I
authors.initials: I
authors.lastname: Berger
authors.forename: A
authors.initials: A
authors.lastname: Kogan
authors.forename: S
authors.initials: S
authors.lastname: Yurman
authors.forename: M
authors.initials: M
authors.lastname: Goldberg
authors.forename: D
authors.initials: D
authors.lastname: Kohelet
mesh_terms: D001724:Birth Weight; D015331:Cohort Studies; D003907:Dexamethasone / Q000627:therapeutic use*; D005865:Gestational Age; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D007226:Infant Mortality; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D007557:Israel / Q000453:epidemiology; D008171:Lung Diseases / Q000139:chemically induced*; D012121:Respiration, Artificial / Q000379:methods*; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone