Trypanocidal tetrahydrofuran lignans from inflorescences of Piper solmsianum.
In addition to sitosterol, syringaldehyde, 3,4,5-trimethoxybenzoic acid, isoelemicin and grandisin, two new tetrahydrofuran lignans were isolated from Piper solmsianun and characterized as rel-(7R,8R,7'R,8'R)-3',4'-methylenedioxy-3,4,5,5'-tetramethoxy-7,7'-epoxylignan and rel-(7R,8R,7'R,8'R)-3,4,3',4'-dimethylenedioxy-5,5'-dimethoxy-7,7'-epoxylignan on the basis of spectroscopic data, including 2D NMR spectrometric techniques. Their in vitro activity were determined against the trypomastigote form of Trypanossoma cruzi.
Martins
Roberto C C
RC
Instituto de Química, Universidade de São Paulo, C.P. 26077, 05513-970 São Paulo, Brazil.
Lago
João Henrique G
JH
Albuquerque
Sergio
S
Kato
Massuo J
MJ
D000818:Animals; D001681:Biological Assay / Q000379:methods; D035264:Flowers / Q000737:chemistry; D005663:Furans / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D031701:Piper / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects / Q000235:genetics
D005663:Furans; D017705:Lignans; D014344:Trypanocidal Agents