Twenty years of renal transplantation at Ohio State University: the results of five eras of immunosuppression.
Over the past 20 years, more than 4,000 patients have undergone an abdominal solid organ transplant at Ohio State University. The 20-year period can be divided into five eras, each defined by an immunosuppressive protocol used during that period. With each successful era came a new immunosuppressive protocol that produced an incremental improvement in outcomes of patients and graft survival resulting from the application of the newest and most sophisticated combination of immunosuppressive drugs. The incidence of acute rejection episodes and graft survival from each era are compared and demonstrate the substantial improvement in results that has been achieved over the past 20 years.
Ferguson
Ronald M
RM
Department of Surgery, Ohio State University College of Medicine and Public Health, Ohio State University Medical Center, 363 Means Hall,1654 Upham Dr., Columbus, OH 43210, USA. ferguson-2@medctr.osu.edu
Henry
Mitchell L
ML
Elkhammas
Elmahdi A
EA
Davies
Elizabeth A
EA
Bumgardner
Ginny L
GL
Pelletier
Ronald P
RP
Rajab
Amer
A
D006084:Graft Rejection / Q000517:prevention & control; D006085:Graft Survival; D049673:History, 20th Century; D006801:Humans; D007165:Immunosuppression Therapy / Q000266:history*; D007166:Immunosuppressive Agents / Q000266:history* / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000266:history* / Q000276:immunology; D007902:Length of Stay; D009820:Ohio; D012577:Schools, Medical / Q000266:history*; D016019:Survival Analysis
D007166:Immunosuppressive Agents