title: Microdialysis in pain research.
abstract: In vivo microdialysis has been used in preclinical pain research for more than a decade. This valuable tool allows correlations between nociceptive behavior and neurotransmitter release in pain-related CNS sites. However, several methodological issues must be considered to adequately interpret microdialysis data. Thus, the aim of this review is to describe key considerations, potential pitfalls, and important control experiments. We focus on animal experiments which evaluate the effects of noxious stimulation on CNS neurotransmitter release, particularly those that address clinically relevant problems in patients with long-lasting painful conditions.
authors.affiliation: Division of Clinical Pharmacology, Department of Medicine, Karolinska Hospital, SE-17177, Stockholm, Sweden.
authors.forename: Carl-Olav
authors.initials: CO
authors.lastname: Stiller
authors.forename: Bradley K
authors.initials: BK
authors.lastname: Taylor
authors.forename: Bengt
authors.initials: B
authors.lastname: Linderoth
authors.forename: Henrik
authors.initials: H
authors.lastname: Gustafsson
authors.forename: Abdullahi
authors.initials: A
authors.lastname: Warsame Afrah
authors.forename: Ernst
authors.initials: E
authors.lastname: Brodin
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001921:Brain; D006801:Humans; D017551:Microdialysis; D018377:Neurotransmitter Agents / Q000378:metabolism; D010146:Pain / Q000188:drug therapy*; D013116:Spinal Cord
chemical_list: D000700:Analgesics; D018377:Neurotransmitter Agents