[Effect T-activin on the activity of the natural killer cells after acute intoxication by toxic chemical substances].
The results of experiments on male mongrel mice showed that a three-day treatment with T-activin in a dose of 2.5 micrograms/kg restored the activity of natural killer cells reduced by acute poisoning (1 LD50) with ethylene glycol (EG), methanol (MeOH), and ethanol (EtOH). In a dose of 5 micrograms/kg, T-activin produced the same action in the test animals upon acute poisoning with dimethyldichlorovinyl phosphate (DDVP), carbophos (CP), dichloroethane (DE), acrylonitrile (AN), Acetonitrile (AcN), atropine (AT). The degree of suppression of the native killer cell activity by the above chemicals increases in the following order: EtOH < EG < MeOH < CP < AT < AcN < DE < AN < DDVP.
Zabrodskiĭ
P F
PF
Saratov Military Institute of Radiation, Chemical, and Biological Defense, Saratov, Russia.
Germanchuk
V G
VG
Kirichuk
V F
VF
Molotkov
A O
AO
Mal'tseva
G M
GM
Osipov
O V
OV
Nodel'
M L
ML
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003602:Cytotoxicity, Immunologic; D015386:Hazardous Substances / Q000633:toxicity*; D007694:Killer Cells, Natural / Q000187:drug effects*; D008297:Male; D051379:Mice; D010455:Peptides / Q000494:pharmacology*; D011041:Poisoning / Q000276:immunology*; D013949:Thymus Extracts / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D015386:Hazardous Substances; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin