title: [Migration of water in soft gelatin capsules].
abstract: Manufacture of soft gelatine capsules in a one-cycle manufacturing process dependent on the quality of gelatine mass and the properties of the filling. Capsules are sensitive to aerial moisture and require observance of the temperature prescribed for their manufacture and storing. Moisture (water) can migrate into the shell, or into the filling of capsules and thus affect both the quality and stability of the capsules produced. The quality of capsules is also influenced by the composition of gelatine mass, composition of the filling, and migration of the components of the filing into the shell. The present experimental paper is devoted to the effect of viscosity of gelatine mass, thickness of gelatine ribbons, and the selected method of drying of capsules on the migration of water from the shell into the filling of capsules. The appearance of the filling of capsules in connection with the above-stated factors is also examined.
authors.affiliation: Ustav technologie léků Farmaceutické fakulty Veterinární a farmaceutické univerzity, Brno. jan.kolcak@seznam.cz
authors.forename: J
authors.initials: J
authors.lastname: Kolcák
authors.forename: M
authors.initials: M
authors.lastname: Stuchlík
authors.forename: M
authors.initials: M
authors.lastname: Rabisková
mesh_terms: D002214:Capsules; D002626:Chemistry, Pharmaceutical; D005780:Gelatin; D014867:Water
chemical_list: D002214:Capsules; D014867:Water; D005780:Gelatin