title: Cardiovascular hemodynamics: relationships with insulin resistance in obese children.
abstract: We investigated blood pressure (BP), cardiac output (CO), and systemic vascular resistance (SVR) and their relationships with insulin and glucose blood levels in a group of 24 obese children (mean age, 11.9 +/- 2.1 years; 19 males). The data were compared to those obtained from a group of 19 healthy controls of the same age (12.4 +/- 2.1 years; p = NS; 13 males). BP at rest was measured and all subjects underwent an exercise testing on the treadmill (Bruce Prot.), time of exercise, maximal heart rate, maximum systolic blood pressure, CO, and SVR at rest and at peak exercise were considered. Only in the OC group were an oral glucose tolerance test were performed to calculate insulin sensitivity index (ISI) and echocardiography performed to determine the left ventricular mass (LVM). The relationships between cardiovascular and metabolic parameters were investigated. Student's t-test and linear regression analysis were used when appropriate. OC had a significant reduction in TE and higher BP, and linear regression analysis showed significant correlations between BP, ISI, and LVM. We speculate that OC need a regular cardiovascular and metabolic screening to prevent the development of early cardiovascular damage.
authors.affiliation: Sports Medicine Unit, Pediatrics Department, Bambino Gesù Children's Hospital, Research Institute, Piazza S. Onofrio, 4, 00165 Rome, Italy. giordano@opbg.net
authors.forename: U
authors.initials: U
authors.lastname: Giordano
authors.forename: P
authors.initials: P
authors.lastname: Ciampalini
authors.forename: A
authors.initials: A
authors.lastname: Turchetta
authors.forename: l A
authors.initials: lA
authors.lastname: Santilli
authors.forename: F
authors.initials: F
authors.lastname: Calzolari
authors.forename: A
authors.initials: A
authors.lastname: Crinò
authors.forename: E
authors.initials: E
authors.lastname: Pompei
authors.forename: B S
authors.initials: BS
authors.lastname: Alpert
authors.forename: A
authors.initials: A
authors.lastname: Calzolari
mesh_terms: D002302:Cardiac Output; D016022:Case-Control Studies; D002648:Child; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D005951:Glucose Tolerance Test; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006439:Hemodynamics; D006801:Humans; D007333:Insulin Resistance; D016014:Linear Models; D008297:Male; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology*