title: Fibrillary glomerulonephritis with hypocomplementemia.
abstract: A 59-year-old man was referred for evaluation of nephrotic syndrome. The patient was diagnosed to have rheumatoid arthritis and had been treated for 10 years. Renal biopsy showed mesangial proliferation with small nodular formations, which were determined as fibrillary deposits (average diameter: 20 nm) by electromicroscopy. Congo-red stain was negative. The laboratory findings revealed hypocomplementemia and lambda type of Bence-Jones protein in urine without other systemic diseases including multiple myeloma. Immunosuppressive therapy did not attenuate the nephrotic-range proteinuria. Such a case of fibrillary glomerulonephritis with hypocomplementemia is rare.
authors.affiliation: First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Konta
authors.forename: Ryo
authors.initials: R
authors.lastname: Koizumi
authors.forename: Wakako
authors.initials: W
authors.lastname: Nishida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Abiko
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications; D001536:Bence Jones Protein / Q000652:urine; D003165:Complement System Proteins / Q000032:analysis / Q000276:immunology*; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000209:etiology*; D017211:Treatment Failure
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D001536:Bence Jones Protein; D003165:Complement System Proteins