title: A concise total synthesis of (+/-)-alantrypinone by a novel hetero-Diels-Alder reaction.
abstract: [reaction: see text] An efficient total synthesis of (+/-)-alantrypinone (1) and its 17-epi isomer (17) has been accomplished employing a novel aza-Diels-Alder reaction as the key step. The reaction sequence comprises 8 steps starting from anthranilic acid and proceeds in 13.5% overall yield. An interesting anionic equilibration between 1 and its epimer 17 has also been discovered.
authors.affiliation: Department of Chemistry, University of Rochester, Rochester, New York 14627, USA. kende@chem.rochester.edu
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Kende
authors.forename: Junfa
authors.initials: J
authors.lastname: Fan
authors.forename: Zecheng
authors.initials: Z
authors.lastname: Chen