title: Cytoadherence and sequestration in Plasmodium falciparum: defining the ties that bind.
abstract: Infected erythrocytes containing the more mature stages of the human malaria Plasmodium falciparum may adhere to endothelial cells and uninfected red cells. These phenomena, called sequestration and rosetting, respectively, are involved in both host pathogenesis and parasite survival. This review provides a critical summary of recent advances in the characterization of the molecules of the infected red blood cell involved in adhesion, i.e. parasite-encoded molecules (PfEMP1, MESA, rifins, stevor, clag 9, histidine-rich protein), a modified host membrane protein (band 3) and exofacial exposure of phosphatidylserine, as well as receptors on the endothelium, i.e. thrombospondin, CD36, ICAM-1 (intercellular adhesion molecule), and chondroitin sulfate.
authors.affiliation: Department of Biology, University of California, Riverside, CA 92521, USA. irwin.sherman@ucr.edu
authors.forename: Irwin W
authors.initials: IW
authors.lastname: Sherman
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Eda
authors.forename: Enrique
authors.initials: E
authors.lastname: Winograd
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology*; D004912:Erythrocytes / Q000469:parasitology* / Q000502:physiology*; D006801:Humans; D008288:Malaria / Q000469:parasitology / Q000503:physiopathology*; D008565:Membrane Proteins / Q000378:metabolism; D010963:Plasmodium falciparum / Q000502:physiology*; D015800:Protozoan Proteins / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; D015800:Protozoan Proteins