title: In vitro activities of ABT-492, a new fluoroquinolone, against 155 aerobic and 171 anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis.
abstract: ABT-492 exhibited excellent in vitro activities against all 326 aerobic and anaerobic antral puncture sinus isolates tested with MICs (in micrograms per milliliter) at which 90% of the isolates tested were inhibited as follows: Haemophilus influenzae, 0.001; Moraxella catarrhalis, 0.008; and Streptococcus pneumoniae, 0.015. It was four- to sixfold more active than other fluoroquinolones, including against levofloxacin-resistant strains of S. pneumoniae, methicillin-resistant Staphylococcus aureus, and Prevotella species.
authors.affiliation: RM Alden Research Laboratory, Santa Monica, California 90404, USA. EJCGMD@aol.com
authors.forename: Ellie J C
authors.initials: EJ
authors.lastname: Goldstein
authors.forename: Diane M
authors.initials: DM
authors.lastname: Citron
authors.forename: C Vreni
authors.initials: CV
authors.lastname: Merriam
authors.forename: Yumi A
authors.initials: YA
authors.lastname: Warren
authors.forename: Kerin L
authors.initials: KL
authors.lastname: Tyrrell
authors.forename: Helen T
authors.initials: HT
authors.lastname: Fernandez
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests; D010256:Paranasal Sinuses / Q000382:microbiology*; D015363:Quinolones / Q000494:pharmacology*; D012852:Sinusitis / Q000382:microbiology*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C477891:delafloxacin