title: [Immunity in patients with active tuberculous spondylitis].
abstract: Immunological parameters were studied in 45 patients with active tuberculous spondylitis, admitted for surgical treatment, who were divided into 2 groups in accordance with the prevalence of exudative-necrotic, or productive components of inflammation in the vertebral bodies and paravertebral tissues. The patients with a predominantly exudative-necrotic component of inflammation exhibited a severe clinical course with frequent neurological disorders, large abscesses in the paravertebral tissues, inflammatory changes in the leukogram, enhanced specific T-lymphocytic activity in the PPD blast-transformation reaction, significant increases in the levels of tuberculosis antibodies and IgE, IL-2 and it soluble IL-2 receptor RR-alpha, an excessively high increase in the functional activity of neutrophilic granulocytes, and lower with IgG2. The degree of immunological disorders corresponds to the severity of a course of tuberculous spondylitis.
authors.forename: V N
authors.initials: VN
authors.lastname: Gusev
authors.forename: V M
authors.initials: VM
authors.lastname: Ivanov
authors.forename: E I
authors.initials: EI
authors.lastname: Potapenko
authors.forename: O A
authors.initials: OA
authors.lastname: Iakunova
authors.forename: R I
authors.initials: RI
authors.lastname: Shenderova
authors.forename: A E
authors.initials: AE
authors.lastname: Garbuz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013166:Spondylitis / Q000150:complications* / Q000276:immunology*; D014399:Tuberculosis, Spinal / Q000150:complications* / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D014409:Tumor Necrosis Factor-alpha; D007073:Immunoglobulin E