[Expression of glucose transporter-1 in endometrial hyperplasia and well-differentiated endometrioid adenocarcinoma].
OBJECTIVE
To investigate the expression of glucose transporter-1 (GLUT1) in endometrial hyperplasia and well-differentiated endometrioid adenocarcinomas.


METHODS
Sixty formalin fixed, paraffin-embedded sections of various endometrial hyperplasia and well-differentiated endometrioid adenocarcinomas were immunostained with rabbit anti-GLUT1 antibody using streptavidin-biotin method.


RESULTS
Two of 12 simple hyperplasia and one of seven complex hyperplasia without atypia were focally positive in metaplastic epithelia. All complex atypical hyperplasia showed positive in varied degree, and 26 among 28 cases of adenocarcinoma were stained positively.


CONCLUSIONS
Overexpression of GLUT1 is a consistent feature of atypical hyperplasia and adenocarcinoma. GLUT1 immunostaining is found to be helpful in distinguishing hyperplasia with atypia from those without atypia.
Liu
A J
AJ
Department of Pathology, PLA General Hospital, Beijing 100853, China. chenlezh@public.bta.net.cn
Hou
N
N
Chen
L Z
LZ
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D000328:Adult; D003937:Diagnosis, Differential; D004714:Endometrial Hyperplasia / Q000175:diagnosis* / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D005260:Female; D051272:Glucose Transporter Type 1; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009004:Monosaccharide Transport Proteins / Q000032:analysis / Q000096:biosynthesis*
D051272:Glucose Transporter Type 1; D009004:Monosaccharide Transport Proteins; C495677:SLC2A1 protein, human