Alteration in thyroid after formaldehyde (HCHO) treatment in rats.
Formaldehyde (HCHO) exposure in industry causes health impairment, especially immune profile. Male albino rats when exposed to HCHO at 5, 10, 15 mg/kg day for 30 days showed decrease in thyroid weight in 10, 15 mg/kg/day HCHO fed group with commensurate follicular regression (epithelial cells), decreased triiodothyronine (T3), thyroxin (T4) deficiency and enhanced thyroid stimulating hormone (TSH). Repeated chemical stimulation might have increased thyroid activity of the follicles and rapidly deteriorated the capacity for synthesis of thyroxin hormone and thus becomes atrophied. The chronic action of HCHO on thyroid may be due to a block at the source of thyroid hormone (s).
Patel
Kumud G
KG
Department of Endocrinology National Institute of Occupational Health, Meghani Nagar, Ahmedabad 380016, Gujarat, India.
Bhatt
H Venkatakrishna
HV
Choudhury
A Roy
AR
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde / Q000633:toxicity*; D007194:India; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects* / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D005557:Formaldehyde; D013972:Thyrotropin; D013974:Thyroxine