Is the soluble KDI domain of gamma1 laminin a regeneration factor for the mammalian central nervous system?
Regeneration of adult mammalian CNS is poor as a result of environmental factors that prevent axon growth. The major factors hampering regeneration of central axons include proteins released from the damaged myelin sheets of the injured neuronal pathways and formation of the glial scar. By using an experimental model of human CNS injury, we show that survival and neurite outgrowth of human central neurons are significantly enhanced by the soluble KDI domain of gamma1 laminin. Our results indicate that the KDI domain appears to neutralize both glia-derived inhibitory signals and inhibitory molecules released from the myelin of the adult human spinal cord. We propose that the KDI domain may enhance regeneration of injuries in the adult mammalian CNS.
Liebkind
Ron
R
The Brain Laboratory, Institute of Biomedicine (Anatomy), Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.
Laatikainen
Timo
T
Liesi
Päivi
P
D000328:Adult; D001253:Astrocytes / Q000473:pathology / Q000502:physiology*; D002470:Cell Survival; D002478:Cells, Cultured; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology / Q000502:physiology; D005333:Fetus; D006801:Humans; D007797:Laminin / Q000378:metabolism*; D009186:Myelin Sheath / Q000378:metabolism; D009414:Nerve Growth Factors / Q000378:metabolism*; D009416:Nerve Regeneration / Q000502:physiology*; D016501:Neurites / Q000378:metabolism / Q000648:ultrastructure; D009474:Neurons / Q000473:pathology / Q000502:physiology* / Q000648:ultrastructure; D017434:Protein Structure, Tertiary / Q000502:physiology
D007797:Laminin; D009414:Nerve Growth Factors; C089141:laminin gamma 1