Blood purification therapies using dextran sulfate cellulose columns Liposorber and Selesorb.
Liposorber is a column used for plasma purification that adsorbs low-density lipoproteins with high selectivity, while Selesorb is a column that selectively adsorbs anti-DNA antibodies, anticardiolipin antibodies, and immune complexes. Both columns are packed with carriers, where a dextran sulfate ligand is bound to porous cellulose beads. Liposorber is used to treat familial hypercholesterolemia (FH), peripheral arterial disease (PAD), and focal segmental glomerulosclerosis (FGS): Selesorb is used to treat systemic lupus erythematosus (SLE). Treatment utilizing both columns is being used effectively in patients with refractory disease that is resistant to pharmacotherapy.
Asahi
Takashi
T
Medical Devices Division, Kaneka Corporation, Osaka, Japan.
Yamamoto
Takashi
T
Kutsuki
Hidetoshi
H
D000042:Absorption; D001672:Biocompatible Materials; D002482:Cellulose; D016264:Dextran Sulfate; D004867:Equipment Design; D004869:Equipment Safety; D005923:Glomerulosclerosis, Focal Segmental / Q000628:therapy; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000628:therapy; D008074:Lipoproteins / Q000097:blood*; D008567:Membranes, Artificial; D016491:Peripheral Vascular Diseases / Q000628:therapy; D010956:Plasmapheresis / Q000295:instrumentation* / Q000379:methods; D012680:Sensitivity and Specificity
D001672:Biocompatible Materials; D008074:Lipoproteins; D008567:Membranes, Artificial; D002482:Cellulose; D016264:Dextran Sulfate