title: Differential FDG accumulation associated with GLUT-1 expression in a patient with lymphoma.
abstract: We herein report a case of malignant lymphoma that showed differential FDG accumulation associated with the degree of glucose transporter 1 (GLUT-1) expression. For clinical staging purpose, FDG-PET was performed on a 47-year-old male who had been diagnosed to have malignant lymphoma, diffuse medium B-cell type. Although an X-ray CT showed multiple and bulky lymphadenopathy including bilateral submandibular, deep cervical, supraclavicular, axillar, hilar, mesenteric and paraaortic regions, FDG-PET showed a high accumulation only in the bilateral submandibular and deep cervical region. An immunohistochemical analysis demonstrated a high GLUT-1 expression in the right cervical lymph node, which showed a high FDG uptake. On the other hand, a bone marrow specimen with diffuse lymphoma cell involvement indicated showed no FDG accumulation and also revealed a negative GLUT-1 expression. This case suggests that the differential FDG accumulation shown by lesions is associated with the degree of GLUT-1 expression in patients with lymphoma.
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. hkoga@radiol.med.kyushu-u.ac.jp
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Koga
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Matsuo
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sasaki
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kaneko
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Hayashi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kuwabara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D027342:Excitatory Amino Acid Transporter 2 / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics
chemical_list: D027342:Excitatory Amino Acid Transporter 2; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18