title: Antimicrobial activity of native chitosan, degraded chitosan, and O-carboxymethylated chitosan.
abstract: The antimicrobial activity of native chitosan was compared to that of lipase-degraded chitosan. The effects of O-carboxymethylated (O-CM) substitution on native (molecular weight, 120; degree of deacetylation, 84.71%) and lipase-degraded chitosans were also investigated. The antimicrobial activity of native chitosan was more extensive than that of lipase-degraded chitosan; however, lipase-degraded chitosan was still highly effective and more water-soluble. O-CM chitosan derived from degraded chitosan was more effective than O-CM chitosan derived from native chitosan. O-CM substitution enhanced lipase-degraded chitosan's antimicrobial activity without reducing its solubility.
authors.affiliation: Department of Packaging Science, Clemson University, Clemson, South Carolina 29634-0370, USA.
authors.forename: Kyung W
authors.initials: KW
authors.lastname: Kim
authors.forename: R L
authors.initials: RL
authors.lastname: Thomas
authors.forename: Chan
authors.initials: C
authors.lastname: Lee
authors.forename: Hyun J
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000107:Acetylation; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D048271:Chitosan; D004305:Dose-Response Relationship, Drug; D008049:Lipase / Q000378:metabolism; D008970:Molecular Weight; D012995:Solubility
chemical_list: D000890:Anti-Infective Agents; D002686:Chitin; D048271:Chitosan; D008049:Lipase