title: [Protective effects of green tea on mice with the irradiating damage induced by gamma-ray].
abstract: OBJECTIVE
  To evaluate the protective effects of green tea on mice with the irradiating damage induced by 60Co-gamma-ray.
  
  
  METHODS
  Thirty-five mice were divided into normal control group, irradiating control group and three experiment groups. The mice of the experiment groups drank in water soluble extractives of green tea (1.25%, 2.5%, 5%) for two weeks. Then all animals were irradiated by 60Co-gamma-ray except those of the normal control group. The animals of three experiment groups continued drinking the water soluble extractives of green tea for one week, after that all mice of the five groups were killed. The levels of malondiadehyde (MDA) and the activities of superoxide dismutase (SOD) in serums, the optical density (OD) value of DNA and the number of karyota of femur, the frequency of micronuclei in polychromatophilic erythrocytes of bone marrow in mice of all groups were measured.
  
  
  RESULTS
  Compared with the measurements in the irradiating control group, the level of MDA in serums and the frequency of micronuclei in polychromatophilic erythrocytes of bone marrow in the three experiment groups were decreased significantly (P < 0.05), while the activities of SOD in serums, the OD value of DNA and the number of karyota of femur in mice of the three experiment groups were increased significantly (P < 0.05).
  
  
  CONCLUSIONS
  The water soluble extractives of green tea have protective effects on mice with the irradiating damage induced by gamma-ray.
authors.affiliation: Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu 610041, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Wang
authors.forename: Lingfu
authors.initials: L
authors.lastname: Zeng
authors.forename: Yuanmei
authors.initials: Y
authors.lastname: Xiao
authors.forename: Suling
authors.initials: S
authors.lastname: Lü
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
mesh_terms: D000818:Animals; D004249:DNA Damage / Q000187:drug effects*; D005260:Female; D005720:Gamma Rays; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood; D013662:Tea / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D011837:Radiation-Protective Agents; D013662:Tea; D013482:Superoxide Dismutase