Analysis of the antiepileptic drug keppra by capillary electrophoresis.
A simple and rapid method for determination of the new antiepileptic drug keppra (levetiracetam) by capillary electrophoresis in borate buffer containing sodium dodecyl sulfate is described. The serum was injected without any treatment. The method compared well to high performance liquid chromatography. The mean of keppra in the serum of 35 patients was 25 mg/l (range 7-77 mg/l).
Shihabi
Z K
ZK
Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. zshihabi@wfubmc.edu
Oles
K
K
Hinsdale
M
M
D000927:Anticonvulsants / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary / Q000379:methods*; D006801:Humans; D000077287:Levetiracetam; D010889:Piracetam / Q000031:analogs & derivatives / Q000097:blood*; D012015:Reference Standards; D015203:Reproducibility of Results
D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam