Time course of ultraviolet B-induced erythema in people with red hair harbouring homozygous melanocortin 1 receptor mutations.
It has previously been reported that the time course of erythema may be delayed in those with sun-sensitive skin types and those with skin cancer. One molecular explanation for this putative phenotype would be that it is caused by mutations of the melanocortin 1 receptor (MC1R). In the present study of 20 persons, 10 of whom were MC1R homozygous, we measured erythema over a 21-day period in response to a range of ultraviolet B doses using methods that improved on previous studies. We could detect no consistent differences in ultraviolet radiation-induced erythema between the groups studied. The pharmacological mechanisms underpinning such prolonged inflammatory responses merit further investigation.
Ha
Thomas K K
TK
Systems Group, Dermatology, University of Edinburgh, Edinburgh, UK.
Waterston
Karen
K
Bisset
Yvonne
Y
Ray
Amanda
A
Rees
Jonathan L
JL
D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D004307:Dose-Response Relationship, Radiation; D004890:Erythema / Q000209:etiology* / Q000235:genetics*; D006200:Hair Color / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D009154:Mutation; D044102:Receptor, Melanocortin, Type 1 / Q000235:genetics*; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*
D044102:Receptor, Melanocortin, Type 1