title: Intravenous administration of class I antiarrhythmic drug induced T wave alternans in an asymptomatic Brugada syndrome patient.
abstract: A 53-year-old man with an abnormal ECG was referred to the Nihon University School of Medicine. The 12-lead ECG showed right bundle branch block and saddleback-type ST elevation in leads V1-V3 (Brugada-type ECG). Signal-averaged ECG showed positive late potentials. Double ventricular extrastimuli (S1: 500 ms, S2: 250 ms, S3: 210 ms) induced VF. Amiodarone (200 mg/day) was administered for 6 months and programmed ventricular stimulation was repeated. VF was induced again by double ventricular stimuli (S1: 600 ms, S2: 240 ms, S3: 170 ms). Intravenous administration of class Ic antiarrhythmic drug, pilsicainide (1 mg/kg), augmented ST-T elevation in leads V1-V3, and visible ST-T alternans that was enhanced by atrial pacing was observed in leads V2 and V3. Visible ST-T wave alternans disappeared in 15 minutes. However, microvolt T wave alternans was present during atrial pacing at a rate of 70/min without visible ST-T alternans.
authors.affiliation: Second Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Kimie
authors.initials: K
authors.lastname: Ohkubo
authors.forename: Ichiro
authors.initials: I
authors.lastname: Watanabe
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Okumura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamada
authors.forename: Riko
authors.initials: R
authors.lastname: Masaki
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kofune
authors.forename: Naohiro
authors.initials: N
authors.lastname: Oshikawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kasamaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Saito
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ozawa
authors.forename: Katsuo
authors.initials: K
authors.lastname: Kanmatsuse
mesh_terms: D000638:Amiodarone / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002037:Bundle-Branch Block / Q000503:physiopathology*; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography / Q000187:drug effects; D022062:Electrophysiologic Techniques, Cardiac; D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted; D013577:Syndrome; D014693:Ventricular Fibrillation / Q000503:physiopathology*
chemical_list: D000889:Anti-Arrhythmia Agents; D008012:Lidocaine; C042288:pilsicainide; D000638:Amiodarone