title: [Methotrexate therapy in rheumatologic diseases--an update].
abstract: This article summarizes the recent literature on low-dose methotrexate in the rheumatologic illnesses. It reviews the efficacy of these agents, the use of combination therapy, and the importance of early treatment with this disease modifying antirheumatic drug. The anti-inflammatory and immunosuppressive effects as well as the toxicity of the drug in rheumatoid arthritis and other diseases are further defined.
authors.affiliation: 5. Medizinische Abteilung mit Rheumatologie, Stoffwechselerkrankungen und Rehabilitation, Wilhelminenspital der Stadt Wien, Montleartstrasse 37, A-1160 Wien. edmund.cauza@akh-wien.ac.at
authors.forename: Edmund
authors.initials: E
authors.lastname: Cauza
authors.forename: Attila
authors.initials: A
authors.lastname: Dunky
mesh_terms: D018501:Antirheumatic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects; D012216:Rheumatic Diseases / Q000188:drug therapy*
chemical_list: D018501:Antirheumatic Agents; D007166:Immunosuppressive Agents; D008727:Methotrexate