Familial leiomyomatosis: a review and discussion of pathogenesis.
Multiple cutaneous leiomyomas of pilar origin have long been recognized to have an autosomal dominant inheritance. While the skin tumors are relatively uncommon and benign, women of affected families often develop uterine fibroids with associated infertility, pain and bleeding. In addition, a subset of these families harbors a predisposition to papillary renal cell carcinoma. Germline mutations in a recently identified classical tumor suppressor gene encoding fumarate hydratase are observed in these individuals. Appropriate screening measures for associated disorders are mandatory.
Garman
M E
ME
Baylor College of Medicine, Houston, Tex., USA.
Blumberg
M A
MA
Ernst
R
R
Raimer
S S
SS
D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics; D018231:Leiomyomatosis / Q000175:diagnosis / Q000235:genetics*; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D012878:Skin Neoplasms / Q000175:diagnosis / Q000235:genetics*; D014594:Uterine Neoplasms / Q000235:genetics