The ASICs: signaling molecules? Modulators?
Acid-sensing ionic channels (ASICs) are almost ubiquitous in the mammalian nervous system, both at the periphery and in the brain. Strong evidence for the physiological function of these molecules has come from recent knockout experiments. Now it is clear that ASICs are important for certain sensory modalities (mechanoreception and nociception) at the periphery and for learning and memory in the brain. The actual mechanisms by which the acid-gated channels serve these functions remain unclear. The question of whether tissue pH is subject to quick fluctuations of a magnitude sufficient to activate ASICs is a crucial point that will determine the functional significance of these channels.
Krishtal
Oleg
O
Bogomoletz Institute of Physiology, Bogomoletz Str. 4, 01024, Kiev, Ukraine. krishtal@serv.biph.kiev.ua
D062565:Acid Sensing Ion Channels; D000818:Animals; D006863:Hydrogen-Ion Concentration; D007473:Ion Channels / Q000737:chemistry / Q000502:physiology; D007858:Learning / Q000502:physiology; D008565:Membrane Proteins; D008568:Memory / Q000502:physiology; D009419:Nerve Tissue Proteins; D009420:Nervous System / Q000737:chemistry* / Q000378:metabolism; D009424:Nervous System Physiological Phenomena; D009473:Neuronal Plasticity; D010146:Pain / Q000378:metabolism; D010465:Perception / Q000502:physiology; D015222:Sodium Channels / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D014110:Touch / Q000502:physiology
C112231:ASIC3 protein, human; D062565:Acid Sensing Ion Channels; D007473:Ion Channels; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D015222:Sodium Channels