title: Phosphorylcholine-endcapped oligomer and block co-oligomer and surface biological reactivity.
abstract: Phosphorylcholine (PC)-endcapped oligomer and block co-oligomer were prepared by employing a photoiniferter-based quasi-living polymerization technique. The designed oligomer had a PC polar head group attached to an alkylene chain at one end of the molecule and an oligo(styrene) (oligoST) segment at the other end. In the co-oligomer, an oligo(N,N-dimethylacrylamide) (oligoDMAAm) segment was inserted between both ends of the oligomer mentioned above. Surface coating of these amphiphilic substances, using an appropriate coating procedure, resulted in a very hydrophilic characteristic, suggesting that the oligoST anchored on the substrate and the PC polar head group was exposed to or located on the outer coating layer. Non-cell adhesivity in serum-containing medium was observed, while slightly reduced protein adsorption was observed. Thus, PC-endcapped oligomer and block co-oligomer appear to function as a biocompatible coating.
authors.affiliation: National Cardiovascular Center Research Institute, Department of Bioengineering, 5-7-1, Fujishiro-dai, Suita, Osaka 565-8565, Japan. matsuda@med.kyushu-u.ac.jp
authors.forename: Takehisa
authors.initials: T
authors.lastname: Matsuda
authors.forename: Junichi
authors.initials: J
authors.lastname: Nagase
authors.forename: Akane
authors.initials: A
authors.lastname: Ghoda
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hirano
authors.forename: Satoru
authors.initials: S
authors.lastname: Kidoaki
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Nakayama
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis; D004121:Dimethyl Sulfoxide; D009682:Magnetic Resonance Spectroscopy; D010767:Phosphorylcholine / Q000737:chemistry*; D012997:Solvents; D020349:Surface Plasmon Resonance; D013499:Surface Properties
chemical_list: D012997:Solvents; D010767:Phosphorylcholine; D004121:Dimethyl Sulfoxide