Hypotensive activity of ultralow doses of antibodies to factors involved in the regulation of vascular tone.
Hypotensive activity of ultralow doses of antibodies to some endogenous substances involved in the regulation of vascular tone was studied on NISAG rats with hereditary stress-induced arterial hypertension. It was found that antibodies to angiotensin II and its receptor in ultralow doses markedly reduced systolic blood pressure, which was reproducible after repeated treatment. The course of peroral treatment with antibodies to endothelin and endothelial NO synthase in ultralow doses did not decrease systolic blood pressure.
Markel'
A L
AL
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk.
Kudryashova
D R
DR
Martyushev
A V
AV
Epstein
O I
OI
Shtark
M B
MB
D000804:Angiotensin II / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D016232:Endothelins / Q000276:immunology*; D008297:Male; D019001:Nitric Oxide Synthase / Q000276:immunology*; D051381:Rats
D000906:Antibodies; D000959:Antihypertensive Agents; D016232:Endothelins; D000804:Angiotensin II; D019001:Nitric Oxide Synthase