Biosynthesis of epothilone intermediates with alternate starter units: engineering polyketide-nonribosomal interfaces.
O'Connor
Sarah E
SE
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA.
Walsh
Christopher T
CT
Liu
Fei
F
D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D001665:Binding Sites; D034261:Epothilones / Q000096:biosynthesis* / Q000737:chemistry; D005818:Genetic Engineering; D018942:Macrolides / Q000737:chemistry; D008969:Molecular Sequence Data; D010453:Peptide Synthases / Q000737:chemistry / Q000378:metabolism; D020836:Protein Structure, Quaternary
D000970:Antineoplastic Agents; D034261:Epothilones; D018942:Macrolides; D010453:Peptide Synthases; C104385:non-ribosomal peptide synthase