Gastritis associated with Helicobacter-like organisms in baboons.
Subclinical gastritis was observed in 10 of 10 baboons (Papio spp.) from a toxicity study in a research facility. The lesions were similar in xenobiotic-treated and control animals, suggesting a spontaneous rather than chemical-induced disease. Histologic examination revealed lymphoplasmacytic gastritis in the antral mucosa. The fundic mucosa contained minor, scattered aggregates of lymphocytes and plasma cells. A Warthin-Starry silver stain and ultrastructural examination revealed numerous spiral-shaped bacteria morphologically resembling Helicobacter pylori in antral glands and numerous spiral-shaped bacteria morphologically consistent with H. heilmannii-like organisms in fundic glands. Polymerase chain reaction assay of paraffin-embedded antral and fundic tissue using primers for the urease gene and 16S ribosomal ribonucleic acid gene amplified deoxyribonucleic acid fragments with a high degree of sequence homology for H. pylori and H. heilmannii. This is the first report of gastritis associated with Helicobacter-like organisms in baboons.
Mackie
J T
JT
IDEXX-Veterinary Pathology Services, PO Box 1119, Coorparoo DC, Qld 4151, Australia. john-mackie@idexx.com
O'Rourke
J L
JL
D000818:Animals; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology / Q000648:ultrastructure; D005756:Gastritis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D016481:Helicobacter Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D018247:Helicobacter heilmannii / Q000235:genetics / Q000302:isolation & purification*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006651:Histocytochemistry / Q000662:veterinary; D008297:Male; D010215:Papio / Q000382:microbiology*