title: Efficacy of a canarypox virus-vectored vaccine against feline leukaemia.
abstract: Canarypox virus recombinant vaccines have a unique efficacy and safety profile for the vaccinated host because the canarypox virus is non-replicative in mammalian hosts. After the vaccination of a mammalian species, recombinant canarypox viruses express the inserted genes but cannot multiply in the host. They stimulate a strong immune response in the absence of any virus amplification in the host or any viral spread into the environment. A new canarypox-based recombinant vaccine is the canarypox-feline leukaemia virus (FeLV) vaccine (EURIFEL FeLV; Merial) that expresses the FeLV env and gag protective genes. This paper describes experiments which demonstrate that it is effective against any oronasal FeLV challenge. The protection was shown to be solid against an oronasal challenge one year after the initial vaccination, and was effective against a very severe 'in-contact' challenge. Furthermore, the canarypox virus-FeLV vaccine was effective without an adjuvant.
authors.affiliation: Merial, Laboratoire de Lyon Gerland, 254 rue Marcel Merieux, 69007 Lyon, France.
authors.forename: H
authors.initials: H
authors.lastname: Poulet
authors.forename: S
authors.initials: S
authors.lastname: Brunet
authors.forename: C
authors.initials: C
authors.lastname: Boularand
authors.forename: A L
authors.initials: AL
authors.lastname: Guiot
authors.forename: V
authors.initials: V
authors.lastname: Leroy
authors.forename: J
authors.initials: J
authors.lastname: Tartaglia
authors.forename: J
authors.initials: J
authors.lastname: Minke
authors.forename: J C
authors.initials: JC
authors.lastname: Audonnet
authors.forename: P
authors.initials: P
authors.lastname: Desmettre
mesh_terms: D000818:Animals; D000917:Antibody Formation; D028121:Canarypox virus / Q000235:genetics*; D002415:Cats; D002642:Chick Embryo; D005786:Gene Expression Regulation; D005256:Leukemia Virus, Feline / Q000276:immunology*; D016582:Leukemia, Feline / Q000276:immunology / Q000517:prevention & control*; D014614:Vaccines, Synthetic / Q000276:immunology* / Q000494:pharmacology*
chemical_list: D014614:Vaccines, Synthetic