title: Age-associated decrease in 8-hydroxy-2'-deoxyguanosine (8-OHdG) immunoreactivity in the autopsied brain.
abstract: The 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a DNA base modified by reactive oxygen species (NOS). The 8-OHdG has been shown to be generated in the brain during ischemia-reperfusion. We performed the immunohistochemical study of 8-OHdG in the brains of autopsied specimens. Age had a statistically significantly negative correlation with 8-OHdG immunoreactivity in glial cells. The 8-OHdG immunoreactivity in glial cells was not increased in the surrounding border of the infarction compared with the non-ischemic areas in the same cases. There was no statistically significant difference in the disease-free areas between infarction and the age-matched control cases. This indicates that 8-OHdG immunoreactivity may not be a sensitive tool to evaluate the infarction injury in human autopsied specimens.
authors.affiliation: Department of Legal Medicine, Teikyo University School of Medicine, Tokyo, Japan. mnogami@med.teikyo-u.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Nogami
authors.forename: Junji
authors.initials: J
authors.lastname: Shiga
authors.forename: Noriko
authors.initials: N
authors.lastname: Inuzuka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Takatsu