Myxoid liposarcoma confirmed by TLS/FUS-CHOP fusion transcripts.
Described here is the use of detecting TLS/FUS-CHOP fusion transcripts to confirm the diagnosis of a myxoid liposarcoma by nested reverse transcription-polymerase chain reaction assay using archival formalin-fixed, paraffin-embedded tissues of a young man with a benign-looking myxoid tumor on his upper extremity, which is often misdiagnosed clinically or histopathologically as a benign tumor.
Huang
Yau-Li
YL
Department of Dermatology, Chang Gung Memorial Hospital, 199 Tung-Hwa North Road, Taipei 105, Taiwan.
Hong
Hong-Shang
HS
Kuo
Tseng-Tong
TT
Chung
Chi-Jung
CJ
D000328:Adult; D017398:Alternative Splicing / Q000235:genetics*; D001132:Arm; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics*; D006801:Humans; D018208:Liposarcoma, Myxoid / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D012334:RNA, Neoplasm / Q000235:genetics*; D034702:RNA-Binding Protein FUS / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000235:genetics*; D051742:Transcription Factor CHOP
D022762:CCAAT-Enhancer-Binding Proteins; D015514:Oncogene Proteins, Fusion; D012334:RNA, Neoplasm; D034702:RNA-Binding Protein FUS; C106030:TLS-CHOP fusion protein, human; D051742:Transcription Factor CHOP