title: Clinical use of dexmedetomidine as premedicant in cats undergoing propofol-sevoflurane anaesthesia.
abstract: The purpose of this report was to evaluate the cardiorespiratory effects and efficacy of dexmedetomidine as a premedicant agent in cats undergoing ovariohysterectomy anaesthetized with propofol-sevoflurane. Cats were randomly divided into two groups of eight animals each. Dexmedetomidine (0.01 mg/kg) or 0.9% saline was administered intravenously (D and S, respectively). After 5 min, propofol was administered intravenously and anaesthesia was maintained with sevoflurane. Heart and respiratory rates, arterial blood pressure, oxygen saturation, rectal temperature and the amount of propofol needed for induction were measured. Premedication with dexmedetomidine reduced the requirement of propofol (6.7+/-3.8 mg/kg), but induced bradycardia, compared with the administration of saline (15.1+/-5.1 mg/kg). Recovery quality was significantly better in D but no significant difference in time to return of swallowing reflex was observed between groups (D=2.5+/-0.5 min; S=3.2+/-1.8 min). In conclusion, dexmedetomidine is a safe and effective agent for premedication in cats undergoing propofol-sevoflurane anaesthesia with minimal adverse effects.
authors.affiliation: Faculdade de Agronomia e Medicina Veterinária, Universidade de Brasília, Distrito Federal CEP 70910-970, Brasília, Brazil.
authors.forename: G M
authors.initials: GM
authors.lastname: Mendes
authors.forename: A L
authors.initials: AL
authors.lastname: Selmi
authors.forename: G R
authors.initials: GR
authors.lastname: Barbudo-Selmi
authors.forename: B T
authors.initials: BT
authors.lastname: Lins
authors.forename: J P
authors.initials: JP
authors.lastname: Figueiredo
mesh_terms: D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats / Q000502:physiology*; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D007044:Hysterectomy / Q000662:veterinary; D007262:Infusions, Intravenous / Q000662:veterinary; D008738:Methyl Ethers / Q000008:administration & dosage*; D010052:Ovariectomy / Q000662:veterinary; D011292:Premedication / Q000662:veterinary; D015742:Propofol / Q000008:administration & dosage*; D012119:Respiration / Q000187:drug effects; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D008738:Methyl Ethers; D000077149:Sevoflurane; D020927:Dexmedetomidine; D015742:Propofol