title: Reversible cortical blindness after lung transplantation.
abstract: Cyclosporine (CYA) is a calcineurin inhibitor widely used in immunosuppressive regimens after organ transplantation. Several neurologic side effects are frequently associated with CYA use; however, reversible cortical blindness is a rare manifestation of CYA toxicity traditionally seen after liver and bone marrow transplantation. This report presents a case of reversible cortical blindness after lung transplantation, then details the risk factors and clinical course of 28 previously well-documented cases of CYA-induced cortical blindness after transplantation. Identification of known risk factors, clinical clues, and typical radiographic findings may aid in the diagnosis of CYA-induced cortical blindness, since reduction in CYA dose or cessation of CYA therapy usually permits resolution of the neurologic effects.
authors.affiliation: Department of Multi-Organ Transplant, Ochsner Clinic Foundation, New Orleans, LA, USA.
authors.forename: Mark T
authors.initials: MT
authors.lastname: Knower
authors.forename: Scott D
authors.initials: SD
authors.lastname: Pethke
authors.forename: Vincent G
authors.initials: VG
authors.lastname: Valentine
mesh_terms: D019575:Blindness, Cortical / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016040:Lung Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D011656:Pulmonary Emphysema / Q000601:surgery; D020127:Recovery of Function / Q000502:physiology*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine