Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.
Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and of the whole organism.
Khavinson
V Kh
VKh
St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences. ibg@medport.ru
Bondarev
I E
IE
Butyugov
A A
AA
D000818:Animals; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology*; D005434:Flow Cytometry; D006367:HeLa Cells; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009842:Oligopeptides / Q000494:pharmacology*; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D019098:Telomerase / Q000235:genetics / Q000378:metabolism*; D016615:Telomere / Q000378:metabolism*
D009842:Oligopeptides; D021122:Protein Subunits; D019098:Telomerase; C421253:alanyl-glutamyl-aspartyl-glycine