title: Usefulness of [123I]metaiodobenzylguanidine ([123I]MIBG) myocardial scintigraphy in differentiating between Alzheimer's disease and dementia with Lewy bodies.
abstract: OBJECTIVE
  To confirm the clinical usefulness of [123I] metaiodobenzylguanidine ([123I]MIBG) myocardial scintigraphy in the antemortem differential diagnosis between patients with Alzheimer's disease (AD) and those with dementia with Lewy bodies (DLB).
  
  
  METHODS
  We compared cardiac [123I] MIBG uptake in 10 patients with AD with that in 10 patients with DLB. We selected the patients with AD or DLB by using stringent diagnostic criteria that combined commonly used clinical criteria with tau protein levels in cerebrospinal fluid and radiographical examinations.
  
  
  RESULTS
  The heart to mediastinum ratio of [123I]MIBG uptake in all the patients with DLB was significantly lower than that in the patients with AD (p<0.01).
  
  
  CONCLUSIONS
  This study confirms that [123I]MIBG myocardial scintigraphy is useful in the antemortem differential diagnosis of AD and DLB.
authors.affiliation: Third Department of Medicine, Shinshu University School of Medicine, Matsumoto.
authors.forename: Takashi
authors.initials: T
authors.lastname: Oide
authors.forename: Takahiko
authors.initials: T
authors.lastname: Tokuda
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Momose
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Oguchi
authors.forename: Akinori
authors.initials: A
authors.lastname: Nakamura
authors.forename: Shinji
authors.initials: S
authors.lastname: Ohara
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging*; D003704:Dementia / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D019275:Radiopharmaceuticals; D016875:tau Proteins; D019797:3-Iodobenzylguanidine