title: The compliance score as a regressor in randomized trials.
abstract: The compliance score in randomized trials is a measure of the effect of randomization on treatment received. It is in principle a group-level pretreatment variable and so can be used where individual-level measures of treatment received can produce misleading inferences. The interpretation of models with the compliance score as a regressor of interest depends on the link function. Using the identity link can lead to valid inference about the effects of treatment received even in the presence of nonrandom noncompliance; such inference is more problematic for nonlinear links. We illustrate these points with data from two randomized trials.
authors.affiliation: Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 602 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104-6021, USA. mjoffe@cceb.upenn.edu
authors.forename: Marshall M
authors.initials: MM
authors.lastname: Joffe
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Ten Have
authors.forename: Colleen
authors.initials: C
authors.lastname: Brensinger
mesh_terms: D015982:Bias; D015984:Causality; D002784:Cholesterol / Q000097:blood; D002792:Cholestyramine Resin / Q000627:therapeutic use; D006801:Humans; D010349:Patient Compliance; D016032:Randomized Controlled Trials as Topic / Q000379:methods* / Q000592:standards; D013223:Statistics as Topic / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D002792:Cholestyramine Resin; D002784:Cholesterol