title: The ion gating effect: using a change in flexibility to allow label free electrochemical detection of DNA hybridisation.
abstract: A label free electrochemical method of detecting DNA hybridisation is presented based on the change in flexibility between a single strand of DNA and a duplex causing an ion-gating effect where hybridisation opens up the electrode to access of ions.
authors.affiliation: School of Chemical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. justin.gooding@unsw.edu.au
authors.forename: J Justin
authors.initials: JJ
authors.lastname: Gooding
authors.forename: Alison
authors.initials: A
authors.lastname: Chou
authors.forename: Freya J
authors.initials: FJ
authors.lastname: Mearns
authors.forename: Elicia Leh-See
authors.initials: EL
authors.lastname: Wong
authors.forename: Kellie L
authors.initials: KL
authors.lastname: Jericho
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D004277:DNA, Single-Stranded / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D007477:Ions; D009693:Nucleic Acid Hybridization / Q000379:methods; D013997:Time Factors
chemical_list: D004277:DNA, Single-Stranded; D007477:Ions; D004247:DNA