[Expression of CD44 variant exon 6 in lung cancers].
Immunohistochemical staining was carried out on 79 samples of lung cancers using anti-CD44v6 antibody. Strong positivity for CD44v6 was observed in the basal cells of bronchial epithelium, squamous metaplasia, and type II pneumocytes. The expression of CD44v6 in primary lesions of non-small cell lung cancers and small cell lung cancers was 67.6% (48/71) and 0% (0/8) respectively, while the expression of CD44v6 in metastases of lymph nodes was 57.6% (19/33) and 0% (0/5), respectively. It is suggest that expression of CD44v6 is correlated with histologic type, differentiation and metastasis of lung cancer.
Wang
F L
FL
Department of Pathology, PLA General Hospital, Beijing 100853, China.
Wei
L X
LX
D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology; D018288:Carcinoma, Small Cell / Q000276:immunology; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology; D008207:Lymphatic Metastasis
C112697:CD44v6 antigen; D006023:Glycoproteins; D018960:Hyaluronan Receptors