Eudesmane derivatives and other sesquiterpenes from Laggera alata.
Three new eudesmane sesquiterpenes, 5 beta-hydroxyilicic acid (1), 5 alpha-hydroxyl-4-epi-ilicic acid methyl ester (2), and 3 alpha-hydroxyilicic acid (3), together with 12 known sesquiterpenes were isolated from the aerial part of Laggera alata. Their structures were elucidated primarily by NMR and mass spectroscopic methods. The structures of 1 and 2 were confirmed by X-ray crystallography.
Zheng
Qun Xiong
QX
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, and Institute of Hangzhou Commerce, Hangzhou, People's Republic of China.
Xu
Zhao Jun
ZJ
Sun
Xian Feng
XF
Guéritte
Françoise
F
Cesario
Michele
M
Sun
Han Dong
HD
Cheng
Christopher H K
CH
Hao
Xiao-Jiang
XJ
Zhao
Yu
Y
D019659:Asteraceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells / Q000187:drug effects; D008175:Lung Neoplasms; D008545:Melanoma; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
C479843:3alpha-hydroxyilicic acid; C479841:5 beta-hydroxyilicic acid; C479842:5alpha-hydroxyl-4-epi-ilicic acid methyl ester; D004365:Drugs, Chinese Herbal; D045787:Sesquiterpenes, Eudesmane