title: [Preparation and the characteristic test of magnetic pingyangmycine-bearing microspheres].
abstract: OBJECTIVE
  To prepare the magnetic pingyangmycine-bearing microspheres (MPMs), test its characteristics, and evaluate the target ability of MPMs.
  
  
  METHODS
  MPMs were prepared by a cold-condensation method at first. Then the scan electron microscope, high performance liquid chromatography (HPLC) and atomic absorption spectrometry were used to measure the diameter of MPMs and the contents of PYM and Fe3O4 in MPMs. Drug-releasing instrument was used to test the quantity of PYM released from MPMs. The distribution of intravenously injected MPMs in SD rat liver was investigated under an externally magnetic field.
  
  
  RESULTS
  MPMs are spherical with the mean diameter of 32.23 microns. The content of pingyangmycine in MPMs was 3.8% and Fe3O4 was 11.7% (w/w). The quantity of PYM released from MPMs in 3 hours was 63.1%. The content of Fe3O4 in the targeting sites of rats was obviously higher than that in the non-targeting sites (P < 0.01).
  
  
  CONCLUSIONS
  MPMs have good properties of drug-targeting and drug sustain releasing. MPMs may be ideal for the use of the treatment of cavernous hemangioma.
authors.affiliation: Department of Stomatology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.forename: Han-jiang
authors.initials: HJ
authors.lastname: Wu
authors.forename: Tian-you
authors.initials: TY
authors.lastname: Ling
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004333:Drug Administration Routes; D016503:Drug Delivery Systems; D006392:Hemangioma, Cavernous / Q000188:drug therapy; D006801:Humans; D008863:Microspheres; D009062:Mouth Neoplasms / Q000188:drug therapy; D004364:Pharmaceutical Preparations; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D001761:Bleomycin; C021771:zhengguangmycin