title: [Nasal/nasopharyngeal T/NK-cell lymphomas with evident angiogenic activity].
abstract: OBJECTIVE
  To search the difference of the angiogenic activity between T/NK-cell lymphomas and B-cell lymphomas.
  
  
  METHODS
  The T/NK-cell was stained immunohistochemically by CD56 and CD45 RO, the B-cell was by CD20, the microvessel endothelium was by CD34. Sixty-one cases were studied to examine the immunophenotype and to estimate the intratumoral microvessel density (iMVD).
  
  
  RESULTS
  Forty in 61 cases (65.6%) expressed the immunophenotype of both T-cell and Natural Killer cell, were diagnosed T/NK-cell lymphomas. Fifteen in 61 cases (24.6%) expressed the immunophenotype of B-cell. There was a significant difference in incidence between the two types of lymphomas (chi 2 = 22.4, P < 0.01). The mean of iMVD/HPF was 24.1 +/- 8.7 in 40 cases of T/NK-cell lymphomas, while the mean of iMVD/HPF was 14.9 +/- 3.8 in 15 cases of B-cell lymphomas. The difference (t = 3.7, P < 0.05) was significant.
  
  
  CONCLUSIONS
  The angiogenic activity of T/NK-cell lymphomas is much more than that of B-cell lymphomas. This study shows nasal/nasopharyngeal T/NK-cell lymphomas are with evident angiogenic activity.
authors.affiliation: Department of Pathology, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: H Y
authors.initials: HY
authors.lastname: Zhang
authors.forename: G S
authors.initials: GS
authors.lastname: Huang
authors.forename: H T
authors.initials: HT
authors.lastname: Zhu
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology*; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000098:blood supply* / Q000276:immunology; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D009669:Nose Neoplasms / Q000098:blood supply* / Q000276:immunology