title: The tethered aminohydroxylation (TA) reaction.
abstract: Since Sharpless' discovery of the asymmetric aminohydroxylation (AA) reaction, a major challenge for chemists has been to find ways of controlling the regio- and stereochemical outcome of this important reaction. Detailed herein is a review of our novel approach towards gaining reliable and predictable regio- and stereocontrol through the use of a tethered carbamate to promote an intramolecular AA reaction, along with a description of the mechanism proposed for this new methodology.
authors.affiliation: The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, UK OX1 3QY. timothy.donohoe@chem.ox.ac.uk
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Donohoe
authors.forename: Peter D
authors.initials: PD
authors.lastname: Johnson
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Pye