Polymer/carrier composites as materials and reactors for organic synthesis.
In this work new polymer/carrier composites are described which serve as novel materials in flow-through reactors for polymer-supported organic solution-phase synthesis. Monolithic polymer/carrier columns are prepared by a new precipitation polymerization process inside the void pore volume of megaporous glass carrier materials. Chemical functionalization of the internal polymer phase with chlorosulfonic acid or trimethylamine generates small, interconnected ion-exchange resin beads with a diameter of 1-3 microm which can be used for a large variety of organic syntheses. These monolithic rods are incorporated into an appropriate casing and can conveniently be operated in the flow-through mode. Important successful applications are polymer-assisted solution-phase reductions, oxidations and Horner-Emmons olefinations. Additionally, the use of these monolithic columns as catalytic microreactors and their performance in selected reactions are described.
Kunz
Ulrich
U
Institut für Chemische Verfahrenstechnik, Technische Universität Clausthal, Leibnizstrasse 17, D-38678 Clausthal-Zellerfeld, Germany. kunz@icvt.tu-clausthal.de
Schönfeld
Hagen
H
Kirschning
Andreas
A
Solodenko
Wladimir
W
D002384:Catalysis; D009930:Organic Chemicals / Q000138:chemical synthesis*; D011108:Polymers / Q000737:chemistry*
D009930:Organic Chemicals; D011108:Polymers