Systemic lupus erythematosus-like autoimmune abnormalities induced by bacterial infection.
Recent evidence has revealed that bacterial DNA can promote several of the autoimmune abnormalities observed in systemic lupus erythematosus (SLE), and a possible pathogenic role in the induction of SLE has been highlighted. We have recently encountered patients in whom bacterial infection (septicemia) triggered the production of several autoantibodies. This seems to be interesting with respect to the consideration of the relationship between SLE and bacterial infection.
Tomita
H
H
Department of Medicine, Juntendo University Izu-Nagaoka Hospital, Shizuoka, Japan.
Yamada
M
M
Sekigawa
I
I
Yoshiike
T
T
Iida
N
N
Hashimoto
H
H
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D016470:Bacteremia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D018570:Risk Assessment; D012720:Severity of Illness Index; D013203:Staphylococcal Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013212:Staphylococcus epidermidis / Q000302:isolation & purification*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D001323:Autoantibodies; D007166:Immunosuppressive Agents