[Study on the myocardiac injury in patients with severe acute respiratory syndrome].
OBJECTIVE
To explore the myocardiac injury in patients with severe acute respiratory syndrome (SARS) and its clinical significance.


METHODS
37 SARS patients fulfilled the Guangdong provincial diagnostic criteria for infectious atypical pneumonia and 35 health controls were investigated. The serum levels of creatine kinase (CK), lactate dehydrogenase (LDH), aspartate transaminase (AST), troponin I (TnI), creatine kinase-MB (CK-MB) and myoglobin (MYO) were measured.


RESULTS
CK, LDH and AST levels in patients were higher than those of control group (P < 0.01); furthermore, among patients the levels were higher in fatal cases than in survivors. The positive rates of TnI, CK-MB and MYO in patients were higher than those in controls (P < 0.05).


CONCLUSIONS
The patients with SARS are subject to complicating myocardiac injury. Therefore, careful monitoring of the myocardiac enzyme profiles is of great importance in reducing the complications and mortality in patients with SARS.
Guan
Yu-juan
YJ
Institute of Infectious Diseases, The Eighth People's Hospital of Guangzhou, Guangzhou 510060, China. zhouguand@hotmail.com
Tang
Xiao-ping
XP
Yin
Chi-biao
CB
Hong
Wen-xin
WX
Lei
Chun-liang
CL
D000293:Adolescent; D000328:Adult; D000368:Aged; D001219:Aspartate Aminotransferases / Q000097:blood; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000209:etiology; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood; D045169:Severe Acute Respiratory Syndrome / Q000150:complications*; D019210:Troponin I / Q000097:blood
D007527:Isoenzymes; D009211:Myoglobin; D019210:Troponin I; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form