title: Effectiveness of auto-cross-linked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic adhesiolysis: a prospective, randomized, controlled study.
abstract: BACKGROUND
  A prospective, randomized, controlled study was performed to assess the efficacy of auto-cross-linked hyaluronic acid (ACP) gel in preventing the development of intrauterine adhesions following hysteroscopic adhesiolysis.
  
  
  METHODS
  Ninety-two patients with irregular menses and intrauterine adhesions referred to the Hysteroscopic Unit of the University of Naples "Federico II". Patients were randomized to two different groups. Group A were randomized to hysteroscopic adhesiolysis plus intrauterine application of ACP gel (10 ml) and group B were randomized to operative hysteroscopy alone (control group). Baseline adhesion scores were calculated for each patient and at 3 months after surgery.
  
  
  RESULTS
  Group A showed a significant decrease in intrauterine adhesions at 3 months follow-up in comparison with the control group. Staging of adhesions showed a significant decrease in adhesion severity in patients treated with ACP gel.
  
  
  CONCLUSIONS
  ACP gel significantly reduces the development of intrauterine adhesions postoperatively and its use is likely to be associated with a reduction of severe adhesions.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy. nappi@unina.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Acunzo
authors.forename: Maurizio
authors.initials: M
authors.lastname: Guida
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Pellicano
authors.forename: Giovanni Antonio
authors.initials: GA
authors.lastname: Tommaselli
authors.forename: Attilio
authors.initials: A
authors.lastname: Di Spiezio Sardo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bifulco
authors.forename: Domenico
authors.initials: D
authors.lastname: Cirillo
authors.forename: Alex
authors.initials: A
authors.lastname: Taylor
authors.forename: Carmine
authors.initials: C
authors.lastname: Nappi
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D015907:Hysteroscopy; D011134:Polysaccharides / Q000737:chemistry* / Q000627:therapeutic use*; D012720:Severity of Illness Index; D000267:Tissue Adhesions / Q000517:prevention & control / Q000601:surgery*; D014591:Uterine Diseases / Q000175:diagnosis / Q000517:prevention & control* / Q000601:surgery*
chemical_list: D005782:Gels; D011134:Polysaccharides; C431864:auto-cross-linked polysaccharide