Cytogenetic effects of lambda-cyhalothrin on Wistar rat bone marrow.
In this study, the genotoxic and cytotoxic potential of lambda-cyhalothrin (LCT), a synthetic pyrethroid insecticide, was investigated in Wistar rat bone-marrow cells, using the structural chromosomal aberration (SCA) and micronucleus (MN) test systems. LCT was administrated to adult female albino rats as repeated i.p. doses of 6.12, 3.06, 0.8 mg/kg BW for 13 days at 48 h intervals. Mitomycin C (MMC) was used as a positive control (2 mg/kg BW). All the doses of LCT increased the number of structural chromosomal aberrations and the frequency of micronucleated erythrocytes, compared with the control group. It was also observed that LCT caused a significant decrease in the number of polychromatic erythrocytes. Our results demonstrate that LCT has a clastogenic/genotoxic potential as measured by the bone marrow SCA and MN tests in Wistar rats.
Celik
Ayla
A
Department of Biology, Faculty of Science and Art, Mersin University, 33342 Mersin, Turkey. a.celik@mersin.edu.tr
Mazmanci
Birgül
B
Camlica
Yusuf
Y
Aşkin
Ali
A
Cömelekoglu
Ulkü
U
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D002869:Chromosome Aberrations; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D048629:Micronuclei, Chromosome-Defective; D015162:Micronucleus Tests; D016685:Mitomycin; D009152:Mutagenicity Tests; D009570:Nitriles; D011722:Pyrethrins / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D016685:Mitomycin; C037304:cyhalothrin