title: Synthesis and photoinduced DNA cleaving activity of hairpin polyamide-chlorobenzenesulfonyl conjugates.
abstract: A hairpin polyamide-chlorobenzenesulfonyl conjugate was synthesized in solution by a haloform reaction and the dicyclohexylcarbodiimide/1-hydroxybenzotriazole (DCC/HOBT) coupling reaction. Its ability to cleave DNA was investigated with supercoiled DNA (pBluescript SK), and the DNA cleaving efficiency of chlorobenzenesulfonyl group was enhanced by the hairpin polyamide under UV irradiation (365 nm).
authors.affiliation: Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Education Ministry, Department of Chemical Biology, College of Chemistry, Peking University, Beijing, People's Republic of China.
authors.forename: Fei Li
authors.initials: FL
authors.lastname: Tang
authors.forename: Gu
authors.initials: G
authors.lastname: Yuan
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology*; D004247:DNA / Q000138:chemical synthesis / Q000187:drug effects / Q000528:radiation effects*; D004278:DNA, Superhelical / Q000737:chemistry / Q000187:drug effects; D008968:Molecular Conformation; D013449:Sulfonamides / Q000138:chemical synthesis / Q000494:pharmacology*; D014466:Ultraviolet Rays; D000096926:Benzenesulfonamides
chemical_list: D000577:Amides; D004247:DNA; D004278:DNA, Superhelical; D013449:Sulfonamides; C479130:N-PyPyPygammaImImImbetaCO-4-aza-4-methylheptyl 4-chlorobenzenesulfonamide; D000096926:Benzenesulfonamides