Effects of peak concentrations on the neurotoxicity of styrene in volunteers.
The manufacture of fibreglass reinforced plastic products may give rise to substantial peak exposures to styrene. Such exposure patterns need further consideration in terms of styrene neurotoxicity. The aim of this study was to evaluate the neurotoxic effects of short-term peak exposures in volunteers, at levels respecting the Quebec occupational exposure limits (8 hours time weighed average of 213 mg/m3 and 15 min average of 426 mg/ m3). The volunteers had not been previously exposed to styrene and they had no documented exposure to known neurotoxicants during the study. Twenty-four volunteers were exposed to five exposure scenarios during 6 hours: a, stable exposure to 106 mg/m3; b, variable exposure with a mean concentration of 106 mg/m3 with four 15 min peaks mounting up to 213 mg/m3; c, stable exposure to 213 mg/m3; d, variable exposure with a mean concentration of 213 mg/m3 and four peaks of 426 mg/m3 and e, two stable exposures to 5 mg/m3 (control). Before and after each exposure scenario, volunteers were submitted to a battery of sensory tests (visual and olfactory), neuropsychological tests (reaction time, attention, memory, psychomotor function), and self-evaluation questionnaires (mood and symptoms) in a test-retest design. The results show that the different exposure scenarios involving peak exposures did not influence either the performance to any test or subjective signs and symptoms. However, due caution must be exercised in extrapolation of the current results to occupational exposure since only acute exposures were tested and volunteers were at rest during exposure, which resulted in lower doses than those experienced by physically active workers.
Ska
B
B
Ecole d'orthophonie et d'audiologie, Faculté de médecine, Université de Montréal, Montréal, Québec, Canada.
Vyskocil
A
A
Tardif
R
R
Carrier
G
G
Thuot
R
R
Muray
K
K
Viau
C
C
D000280:Administration, Inhalation; D000328:Adult; D000339:Affect / Q000187:drug effects; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D003118:Color Perception / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000187:drug effects; D012684:Sensory Thresholds / Q000187:drug effects*; D012903:Smell / Q000187:drug effects; D020058:Styrene / Q000008:administration & dosage / Q000633:toxicity*; D023382:Toxicity Tests, Acute; D014785:Vision, Ocular / Q000187:drug effects
D000395:Air Pollutants, Occupational; D020058:Styrene