Probability models and computational models for ANOVA in multicenter clinical trials.
Multicenter trials are usually analyzed by fixed-effects, two-way analysis of variance. A mixed-effects computation with random treatment-by-center interaction may produce better results even if this interaction is considered truly to be a fixed effect. It may be more appropriate, however, to consider the treatment-by-center interaction to be a random effect, anyway.
Permutt
Thomas
T
Food and Drug Administration, Rockville, Maryland 20857, USA. permuttT@cder.fda.gov
D000704:Analysis of Variance; D008432:Mathematical Computing; D015233:Models, Statistical; D015337:Multicenter Studies as Topic / Q000706:statistics & numerical data*