Low dose, one-week triple therapy (lanzoprazole, amoxycillin, clarithromycin) for eradication of Helicobacter pylori infection.
OBJECTIVE
To evaluate the efficacy and safety of low dose one week triple therapy with lansoprazole, amoxycillin and clarithromycin for the eradication of Helicobacter pylori (H. pylori).


METHODS
A total of 103 patients with H. pylori infection who had gastritis, duodenal ulcer (DU) or gastric ulcer (GU) received 1 week's triple therapy of lansoprazole 30 g once daily (OD), amoxycillin 250 mg qid and clarithromycin 250 mg tid. The status of H. pylori infection was determined using the CLO test and histology (gram stain) of biopsy specimens during endoscopic examination.


RESULTS
After treatment with triple therapy H. pylori infection was eradicated in 98 of 103 patients (95.15%), dyspeptic symptoms and upper gastrointestinal hemorrhage improved in 99 of 103 patients (96.1%). No adverse effect was observed in all the patients was received treatment.


CONCLUSIONS
Low dose one-week triple therapy with lansoprazole, amoxycillin and clarithromycin is effective for eradication of H. pylori infection.
Uthaisaengsook
W
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Medicine Unit, Putachinnaraj Hospital, Phitsanulok 65000, Thailand.
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage*; D017291:Clarithromycin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000382:microbiology; D005260:Female; D005756:Gastritis / Q000382:microbiology; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D064747:Lansoprazole; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage* / Q000031:analogs & derivatives; D010406:Penicillins / Q000627:therapeutic use; D011446:Prospective Studies; D054328:Proton Pump Inhibitors; D013276:Stomach Ulcer / Q000382:microbiology; D016896:Treatment Outcome
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D010406:Penicillins; D054328:Proton Pump Inhibitors; D064747:Lansoprazole; D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole