title: Peripheral T-cell lymphoma associated consecutively with hemophagocytic lymphohistiocytosis and hypereosinophilic syndrome.
abstract: Both hemophagocytic lymphohistiocytosis and hypereosinophilic syndrome have been associated with hematologic neoplasms and are respectively related to an overproduction of the cytokines Thelper 1 (Th1) and Th2 by tumor cells or reactive cells. To our knowledge, this is the first time a case of a peripheral T-cell lymphoma consecutively associated with both paraneoplastic conditions has been reported. Importantly, in this case when the lymphoma exclusively involved the bone marrow, severe paraneoplastic systemic damage, a CD8+ suppressor/cytotoxic phenotype and a hypereosinophilia not related to high levels of interleukin (IL)-5 was found. Interestingly, progression of the lymphoma coincided with an increase in the serum levels of several Th2 cytokines and IL-2, a decrease in tumor necrosis factor and granulocyte-macrophage colony-stimulating factor levels and the onset of a hypereosinophilic syndrome.
authors.affiliation: Hematology and Medical Oncology Department, Pathology Department, Hospital Clínico, University of Valencia, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gutiérrez
authors.forename: Carlos
authors.initials: C
authors.lastname: Solano
authors.forename: Antonio
authors.initials: A
authors.lastname: Ferrández
authors.forename: Isabel
authors.initials: I
authors.lastname: Marugán
authors.forename: María José
authors.initials: MJ
authors.lastname: Terol
authors.forename: Isabel
authors.initials: I
authors.lastname: Benet
authors.forename: Mar
authors.initials: M
authors.lastname: Tormo
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Bea
authors.forename: José
authors.initials: J
authors.lastname: Rodríguez
mesh_terms: D001706:Biopsy; D001854:Bone Marrow Cells / Q000378:metabolism; D017252:CD3 Complex / Q000096:biosynthesis; D016827:CD8 Antigens / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood; D015616:Histiocytosis, Non-Langerhans-Cell / Q000473:pathology*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000473:pathology*; D015848:Interleukin-5 / Q000096:biosynthesis / Q000378:metabolism; D008223:Lymphoma; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications*; D008875:Middle Aged; D010641:Phenotype; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D017252:CD3 Complex; D016827:CD8 Antigens; D015848:Interleukin-5; D016178:Granulocyte-Macrophage Colony-Stimulating Factor