[Gliosis as a trigger of pathomorphological changes in prion diseases].
Experiments with three cell lines revealed that the scraplecontaining cerebral extract, obtained from preliminarily infected 6-month mice, sharply induced the cellular proliferation, which was registered yet in 3 days after incubation. However, the cerebral extract of healthy 6-month mice did not virtually influence the velocity of cells' reproduction in all three cultures. The authors suggest, with respect to published data and to their independently found research results, that the gliosis of primary importance in shaping up the pathomorphological alterations in the cerebral tissue in prion diseases of man and animal.
Zuev
V A
VA
Roĭkhel'
V M
VM
Ignatova
N G
NG
D000818:Animals; D001921:Brain / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line / Q000187:drug effects; D005911:Gliosis / Q000473:pathology*; D051379:Mice; D009457:Neuroglia / Q000473:pathology; D011328:Prions / Q000494:pharmacology; D012608:Scrapie / Q000473:pathology*; D013997:Time Factors; D014020:Tissue Extracts / Q000494:pharmacology
D011328:Prions; D014020:Tissue Extracts