Pharmacological activity of phenazepam and flunitrazepam in ultralow doses.
Experiments on male outbred albino rats showed that benzodiazepine tranquilizers phenazepam and flunitrazepam in ultralow doses (10(-9)-10(-15) mol/kg) produced an anxiolytic effect in the conflict situation test. This effect was not accompanied by myorelaxing and sedative side effects typical of standard doses of tranquilizers.
Molodavkin
G M
GM
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Voronina
T A
TA
Chernyavskaya
L I
LI
Burlakova
E B
EB
Khorseva
N I
NI
Seredenin
S B
SB
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001569:Benzodiazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005445:Flunitrazepam / Q000494:pharmacology*; D008297:Male; D008472:Medazepam / Q000494:pharmacology; D051381:Rats; D014149:Tranquilizing Agents / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D014149:Tranquilizing Agents; D001569:Benzodiazepines; C017928:phenazepam; D005445:Flunitrazepam; D008472:Medazepam