title: [Immunoenzyme technique for analysis of cystatin C in serum of patients with hemoblastosis].
abstract: Cystatin C is a low-molecular endogenous inhibitor of cysteic proteinases. Sets for immune-enzyme assay of cystatin C in human blood serum (KRKK, Slovenia) were made used of in the case study. The concentration of cystatin C (CCC) in blood serum was found to be higher in cases of certain hemoblastoses (Non-Hodgkin's disease, lymphogranulomatosis and multiple myeloma), with the highest concentration of the inhibitor being observed in patients with resistance to the conducted polychemotherapy and a poor prognostication. The treatment of Non-Hodgkin's disease and of lymphogranulomatosis brought about a normalized CCC in blood serum. It was suggested that CCC in blood serum reflects a nature of tumor growth and, obviously, it can be a criterion in assessing the therapy efficiency. The concentration of alpha 1-proteinases inhibitor remained unchanged before and after treatment.
authors.forename: O N
authors.initials: ON
authors.lastname: Poteriaeva
authors.forename: T A
authors.initials: TA
authors.lastname: Usova
authors.forename: O A
authors.initials: OA
authors.lastname: Levina
authors.forename: E S
authors.initials: ES
authors.lastname: Iarygina
authors.forename: T A
authors.initials: TA
authors.lastname: Korolenko
mesh_terms: D000208:Acute Disease; D000307:Adrenal Gland Diseases / Q000097:blood / Q000188:drug therapy; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D019008:Drug Resistance, Neoplasm; D019337:Hematologic Neoplasms / Q000097:blood* / Q000188:drug therapy; D006689:Hodgkin Disease / Q000097:blood / Q000188:drug therapy; D006801:Humans; D007124:Immunoenzyme Techniques; D007938:Leukemia / Q000097:blood / Q000188:drug therapy; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000188:drug therapy; D009101:Multiple Myeloma / Q000097:blood / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins