title: Selective deficiency of naïve CD4+ T-lymphocytes in a child with congenital lymphoedema.
abstract: We describe the first known case of congenital lymphoedema associated with selective deficit of naïve CD4+ T-lymphocytes. A high proportion of naïve CD4+ T-lymphocytes was found in the ascitic fluid, supporting the hypothesis of extra-vascular sequestration of these cells into lymphoedematous tissue.
authors.affiliation: Division of Paediatrics and Infectious Diseases, Department of Paediatrics, University of Florence, Via Luca Giordano 13, 50132 Florence, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Chiappini
authors.forename: Luisa
authors.initials: L
authors.lastname: Galli
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Giudizi
authors.forename: Chiara
authors.initials: C
authors.lastname: Azzari
authors.forename: Augusto Antonio
authors.initials: AA
authors.lastname: Niccoli
authors.forename: Sergio
authors.initials: S
authors.lastname: Romagnani
authors.forename: Maurizio
authors.initials: M
authors.lastname: de Martino
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D000013:Congenital Abnormalities / Q000175:diagnosis; D006801:Humans; D007223:Infant; D007558:Italy; D019041:L-Selectin / Q000378:metabolism*; D008209:Lymphedema / Q000151:congenital* / Q000175:diagnosis*; D008297:Male; D011379:Prognosis; D035583:Rare Diseases; D018570:Risk Assessment
chemical_list: D019041:L-Selectin