title: Comparison of three different purification methods for the routine preparation of [11C] Metomidate.
abstract: PET with (R)-[O-methyl-11C] metomidate ([11C] MTO) is an attractive method for the characterisation of adrenal masses discriminating lesions of adrenal cortical origin from noncortical lesions. [11C] MTO was prepared by the reaction of [11C] methyliodide with the corresponding free acid. Three purification methods have been compared. The method of choice uses preparative HPLC with a ready-to-use weak acidic solvent.
authors.affiliation: Department of Nuclear Medicine, University of Vienna, AKH Wein, Waehringer Guertel 18-20, 1090 Vienna, Austria. markus.mitterhauser@akh-wien.ac.at
authors.forename: Markus
authors.initials: M
authors.lastname: Mitterhauser
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wadsak
authors.forename: Oliver
authors.initials: O
authors.lastname: Langer
authors.forename: Joern
authors.initials: J
authors.lastname: Schmaljohann
authors.forename: Georg
authors.initials: G
authors.lastname: Zettinig
authors.forename: Robert
authors.initials: R
authors.lastname: Dudczak
authors.forename: Helmut
authors.initials: H
authors.lastname: Viernstein
authors.forename: Kurt
authors.initials: K
authors.lastname: Kletter
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging; D002250:Carbon Radioisotopes / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D005045:Etomidate / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000302:isolation & purification*; D007553:Isotope Labeling / Q000379:methods*; D011786:Quality Control; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D002250:Carbon Radioisotopes; C084586:metomidate; D005045:Etomidate