title: Seitomycin: isolation, structure elucidation and biological activity of a new angucycline antibiotic from a terrestrial Streptomycete.
abstract: A new antibiotic, named seitomycin (1c), and the known microbial metabolite tetrangulol methyl ether (2) were found in the ethyl acetate extract of two terrestrial Streptomyces sp. isolates. The structure of the new antibiotic was elucidated by spectroscopic studies and by comparison of the NMR data with the structurally related hatomarubigin C (1a) and SM-196 B (1b). Seitomycin (1c) showed moderate antimicrobial and weak phytotoxic activity, similar to tetrangulol methyl ether (2).
authors.affiliation: Department of Organic Chemistry, University of Göttingen, Tammanstrasse 2, Göttingen D-37077, Germany.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abdelfattah
authors.forename: Rajendra P
authors.initials: RP
authors.lastname: Maskey
authors.forename: Ratnakar N
authors.initials: RN
authors.lastname: Asolkar
authors.forename: Iris
authors.initials: I
authors.lastname: Grün-Wollny
authors.forename: Hartmut
authors.initials: H
authors.lastname: Laatsch
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001551:Benz(a)Anthracenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001551:Benz(a)Anthracenes; C476913:seitomycin