Lack of association of the interleukin-1 receptor antagonist gene with palmoplantar pustulosis in Japanese.
We analysed a polymorphism of the interleukin (IL)-1 receptor antagonist (IL1RN) gene in 93 Japanese patients with palmoplantar pustulosis (PPP). None of the IL1RN alleles was significantly increased in the patients compared with controls. Because PPP has been reported to be associated with the tumour necrosis factor (TNF) region, we examined the association between the TNF and IL1RN genes. There was a difference in IL1RN*2 positivity between patients with and without the AA genotype of the TNF gene. In contrast, such a difference was not found in controls. These data indicate a possible epistatic effect between TNF and IL1RN linked genes for susceptibility to the pathogenesis of PPP.
Niizeki
H
H
Department of Dermantolgy and Clinical Research Institute, National Tokyo Medical Center, Japan.
Yokoyama
M
M
Inamoto
N
N
Nishikawa
T
T
Naruse
T
T
Inoko
H
H
Hashigucci
K
K
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007564:Japan; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D011565:Psoriasis / Q000235:genetics* / Q000378:metabolism; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D012795:Sialoglycoproteins / Q000235:genetics* / Q000378:metabolism
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins