[Disc-like changes and type II collagen mRNA expression in the bilaminar zone of rabbit temporomandibular joint following disc displacement].
OBJECTIVE
To study the adaptive alteration in bilaminar zone of rabbits' temporomandibular joint following disc displacement.


METHODS
Twenty-six Japanese white rabbits were used in this study. Among these rabbits,6 were used as controls. The right discs of other 20 rabbits were displaced anteriorly by operation. Four of these rabbits were killedatn 1, 2, 4, 6 and 8 weeks respectively after surgery. The TMJS were studied by HE staining, Alcin bluen staining and in situ detection of type II collagen mRNA expression.


RESULTS
There appeared cartilage metaplasia after one week following disc displacement. Typical chondrocytes could be found in the bilaminar zone. The new chondrocytes expressed type II collagen.


CONCLUSIONS
The bilaminar zone of TMJ will be remodeled following disc displacement and become a disc-like tissue to function as a disc.
Gu
Zhi-yuan
ZY
Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, College of Medicine, Zhejiang University, Hangzhou 310006, China.
Hu
Ji-an
JA
Feng
Jian-ying
JY
Zhang
Zhen-kang
ZK
Zhang
Yin-kai
YK
D000818:Animals; D024043:Collagen Type II / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D004204:Joint Dislocations / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis; D011817:Rabbits; D019224:Temporomandibular Joint Disc / Q000378:metabolism / Q000473:pathology*; D013705:Temporomandibular Joint Disorders / Q000378:metabolism / Q000473:pathology*
D024043:Collagen Type II; D012333:RNA, Messenger