Breast cancer in association with thyroid disorders.
BACKGROUND
The relationship between breast cancer and thyroid diseases is controversial. Discrepant results have been reported in the literature. The incidences of autoimmune and nonautoimmune thyroid diseases were investigated in patients with breast cancer and age-matched control individuals without breast or thyroid disease.


METHODS
Clinical and ultrasound evaluation of thyroid gland, determination of serum thyroid hormone and antibody levels, and fine-needle aspiration of thyroid gland were performed in 150 breast cancer patients and 100 control individuals.


RESULTS
The mean values for anti-thyroid peroxidase antibodies were significantly higher in breast cancer patients than in control individuals (P = 0.030). The incidences of autoimmune and nonautoimmune thyroid diseases were higher in breast cancer patients than in control individuals (38% versus 17%, P = 0.001; 26% versus 9%, P = 0.001, respectively).


CONCLUSIONS
Our results indicate an increased prevalence of autoimmune and nonautoimmune thyroid diseases in breast cancer patients.
Turken
Orhan
O
GATA Haydarpasa Training Hospital, Medical Oncology Department, KadIkoy, Istanbul, Turkey. oturken@hotmail.com
NarIn
Yavuz
Y
DemIrbas
Sezai
S
Onde
M Emin
ME
Sayan
Ozkan
O
KandemIr
E Gokhan
EG
YaylacI
Mustafa
M
Ozturk
Ahmet
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood; D001943:Breast Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009195:Peroxidase / Q000276:immunology; D015995:Prevalence; D013959:Thyroid Diseases / Q000145:classification / Q000150:complications / Q000201:enzymology / Q000453:epidemiology*; D013963:Thyroid Hormones / Q000097:blood; D013967:Thyroiditis, Autoimmune / Q000145:classification / Q000201:enzymology / Q000453:epidemiology
D001323:Autoantibodies; D013963:Thyroid Hormones; D009195:Peroxidase