[Conformational aspects of biological activity of functional fragments of the p21ras oncoproteins. 3. Fragment 34-46 of the native oncoprotein and the decapeptide corresponding to its 35-44 sequence].
Theoretical conformational analysis was used to study the spatial structure of a putative binding site responsible for binding of p21 oncoproteins to other oncoproteins. Conformational properties of the isolated address sequence localized in fragment 34-46 of native p21 and of the decapeptide molecule corresponding to the 35-44 sequence in the primary structure of oncoproteins of this family were revealed. Our calculations demonstrated a similarity between the spatial structures of the peptides, which confirms the hypothesis on the identity of their biological functions.
Mzareulov
K D
KD
Baku State University, Moskovskii pr. 66-20, Baku, 370033 Azerbaijan. stegocefal@mail.ru
D008958:Models, Molecular; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D016283:Proto-Oncogene Proteins p21(ras) / Q000737:chemistry* / Q000378:metabolism; D040681:Structural Homology, Protein; D018631:ras Proteins / Q000737:chemistry / Q000378:metabolism
D010446:Peptide Fragments; D010455:Peptides; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins