title: [Initial analysis of complete genome sequences of SARS coronavirus].
abstract: Multiple sequence alignment among 12 complete SARS coronavirus (SARS-CoV) sequences reveals that the major parts of 29708 b of the genomes have 99.82% identical bases. Forty two nucleotide mismatches were found in addition to the five and six gaps in two genomes. Among them, 28 mismatches result in changes of amino acid in the encoded proteins. Analysis of the changes implies possible effect on the Spike and Membrane protein of the virus, while most of the other changes seem not very significant to alter the structure and function of the proteins. These results have been released on the anti-sars web site maintained by the Centre of Bioinformatics, Peking University (antisars.cbi.pku.edu.cn) and may be of help for further experimental study.
authors.affiliation: Collge of Life Sciences, Centre of Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, Peking University, Beijing 100871, China.
authors.forename: Yun-Jia
authors.initials: YJ
authors.lastname: Chen
authors.forename: Ge
authors.initials: G
authors.lastname: Gao
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Bao
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Lopez
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Wu
authors.forename: Tao
authors.initials: T
authors.lastname: Cai
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Ye
authors.forename: Xiao-Cheng
authors.initials: XC
authors.lastname: Gu
authors.forename: Jing-Chu
authors.initials: JC
authors.lastname: Luo
mesh_terms: D000595:Amino Acid Sequence; D017934:Coronavirus / Q000235:genetics; D016679:Genome, Viral; D008969:Molecular Sequence Data; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins