Influence of cyclosporin A therapy on bone healing around titanium implants: a histometric and biomechanic study in rabbits.
BACKGROUND
Immunosuppressive agents may induce severe changes on bone metabolism. The purpose of the present study was to evaluate the influence of the administration of cyclosporin A (CsA) on the bone tissue around titanium implants.


METHODS
Eighteen New Zealand rabbits were randomly divided into 2 groups of 9 each. The test group (CsA) received daily subcutaneous injection of CsA (10 mg/kg body weight) and the control group (CTL) received saline solution by the same administration route. Three days after therapy began, 2 implants (7.0 mm long and 3.75 mm in diameter) were inserted bilaterally at the region of the tibial methaphysis. After 4, 8, and 12 weeks the animals were sacrificed and biomechanical tests and histometrical procedures, consisting of the determination of the percentages of bone-implant contact and bone area within the limits of the implant threads, were performed.


RESULTS
Intergroup analysis showed that the removal torque and the percentage of bone contact with the implant surface for CsA group were significantly lower than those of the CTL group at 12 weeks (28.5 and 39.2 N cm, P = 0.01; 7.76% and 18.52%, P = 0.02, respectively).


CONCLUSIONS
The data from the present study suggest that long-term administration of cyclosporin A may negatively influence bone healing around dental implants.
Sakakura
Celso E
CE
Department of Periodontology, Dental School of Araraquara, State University of São Paulo, Araraquara, SP, Brazil.
Margonar
Rogério
R
Holzhausen
Marinella
M
Nociti
Francisco H
FH
Alba
Rodolfo Candia
RC
Marcantonio
Elcio
E
D000818:Animals; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D016572:Cyclosporine / Q000627:therapeutic use*; D015921:Dental Implants; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007279:Injections, Subcutaneous; D016348:Osseointegration; D011817:Rabbits; D011897:Random Allocation; D012965:Sodium Chloride; D018709:Statistics, Nonparametric; D013499:Surface Properties; D013977:Tibia; D013997:Time Factors; D014025:Titanium / Q000737:chemistry; D019415:Torque; D014945:Wound Healing / Q000187:drug effects
D015921:Dental Implants; D007166:Immunosuppressive Agents; D012965:Sodium Chloride; D016572:Cyclosporine; D014025:Titanium