[The role of a radical surgical debridement and mesh graft tissue transfer for treatment of venous ulcers].
Many studies are published demonstrating remarkable results of skin grafting in venous ulcers, but only a few controlled randomised trials including a low number of patients are available. A review based on two controlled randomised trials concludes that there is no significant benefit for mesh graft tissue transfer compared to standard treatment. However, in all studies no adequate initial radical surgical debridement including fasciectomy for wound bed preparation has been performed. In a prospective study on 57 patients with venous ulceration we found significant lower recurrence rates after mesh graft tissue transfer and radical surgical debridement. In clinical practice the results of mesh graft tissue transfer following surgical debridement in the management of larger chronic venous ulcers have been encouraging, although the evidence-based recommendation is lacking. It may not be the treatment of first choice and should be preserved for large ulcers of long duration or history of recurrence. There is need for more randomised controlled studies comparing also cost effectiveness while ensuring baseline comparability.
Beckert
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Klinik für Allgemeine Chirurgie und Poliklinik, Universitätsklinikum Tübingen. Stefan.Beckert@med.uni-tuebingen.de
Coerper
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Becker
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D000818:Animals; D002478:Cells, Cultured; D003646:Debridement; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000637:transplantation; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D012189:Retrospective Studies; D016038:Skin Transplantation; D017768:Skin, Artificial; D013552:Swine; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014647:Varicose Ulcer / Q000601:surgery*