Antibodies to delta sleep-inducing peptide in ultralow doses: effect on the behavior of male mice with anxiety and depressive syndrome.
We studied the effect of antibodies to delta sleep-inducing peptide in ultralow doses on the behavior of male mice with anxiety and depressive syndrome resulting from competitive interactions. The behavior of animals was studied in the elevated plus-maze, partition, and forced swimming tests. The preparation produced a strong anxiolytic effect, which was especially pronounced in animals with anxiety and depressive syndrome.
Lipina
T V
TV
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk.
Mikhnevich
N V
NV
Epstein
O I
OI
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000906:Antibodies / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy; D001522:Behavior, Animal / Q000187:drug effects*; D003701:Delta Sleep-Inducing Peptide / Q000276:immunology*; D003866:Depressive Disorder / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D005082:Physical Exertion / Q000187:drug effects
D014151:Anti-Anxiety Agents; D000906:Antibodies; D003701:Delta Sleep-Inducing Peptide