[Effect of dalarginum on the level of nitric oxide stable metabolites in rat kidneys during apoptosis activation].
The influence of dalarginum on the level of nitric oxide stable metabolites in the rat kidneys was investigated at various models of apoptosis activation (formed by two methods of acute renal failure). Dalarginum (synthetic leu-enkephaline) was entered in a dose of 100 micrograms/kg a day. Detection of apoptosis was carried out by determination of DNA fragmentation. Administration of dalarginum resulted in the significant decrease of NO--nitrite- and nitrate anions stable metabolites content, the latter is capable to be one of the mechanisms of the preparation antiapoptotic effect.
Orlova
E A
EA
Lugansk State Medical University, Ukraine.
Komarevtseva
I A
IA
D058186:Acute Kidney Injury / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D017209:Apoptosis; D004334:Drug Administration Schedule; D016308:Enkephalin, Leucine-2-Alanine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats
D000975:Antioxidants; D009569:Nitric Oxide; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-