[Changes in the activity of NO-synthase, energy metabolism enzymes and ultrastructure in neurons of the cerebral cortex in the model of short-term ischemia].
Experiments were performed on male Wistar rats under nembutal-urethan anesthesia. Short-time (10 min) cerebral ischemia was induced by bilateral ligation of carotid arteries. This was followed by an increased synthesis of NO and activity of energy metabolism enzymes (SDH, LDH) in a part of neurons of the parietal cortex and in endotheliocytes of blood vessels. The ultrastructural changes of some neurons and synaptic formations indicated functional tension, while in the others the irreversible changes (disturbed lipid metabolism, destructive alterations of the nucleus and cytoplasm) were found.
Lapsha
V I
VI
Laboratory of the Physiology of Functional Systems, National Academy of Sciences, Institute of Physiology, Minsk, Belarus.
Bocharova
V N
VN
Gurin
V N
VN
D000818:Animals; D002545:Brain Ischemia / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D004734:Energy Metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D009252:NADPH Dehydrogenase / Q000378:metabolism; D009474:Neurons / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D010296:Parietal Lobe / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013997:Time Factors
D007770:L-Lactate Dehydrogenase; D019001:Nitric Oxide Synthase; D013385:Succinate Dehydrogenase; D009252:NADPH Dehydrogenase