title: Eudesmane derivatives and other sesquiterpenes from Laggera alata.
abstract: Three new eudesmane sesquiterpenes, 5 beta-hydroxyilicic acid (1), 5 alpha-hydroxyl-4-epi-ilicic acid methyl ester (2), and 3 alpha-hydroxyilicic acid (3), together with 12 known sesquiterpenes were isolated from the aerial part of Laggera alata. Their structures were elucidated primarily by NMR and mass spectroscopic methods. The structures of 1 and 2 were confirmed by X-ray crystallography.
authors.affiliation: Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, and Institute of Hangzhou Commerce, Hangzhou, People's Republic of China.
authors.forename: Qun Xiong
authors.initials: QX
authors.lastname: Zheng
authors.forename: Zhao Jun
authors.initials: ZJ
authors.lastname: Xu
authors.forename: Xian Feng
authors.initials: XF
authors.lastname: Sun
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Michele
authors.initials: M
authors.lastname: Cesario
authors.forename: Han Dong
authors.initials: HD
authors.lastname: Sun
authors.forename: Christopher H K
authors.initials: CH
authors.lastname: Cheng
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells / Q000187:drug effects; D008175:Lung Neoplasms; D008545:Melanoma; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: C479843:3alpha-hydroxyilicic acid; C479841:5 beta-hydroxyilicic acid; C479842:5alpha-hydroxyl-4-epi-ilicic acid methyl ester; D004365:Drugs, Chinese Herbal; D045787:Sesquiterpenes, Eudesmane