title: Transient detection of proinflammatory cytokines in sera of colostrum-fed newborn calves.
abstract: To obtain basic information on the state of proinflammatory cytokines in newborn calves, we determined the kinetics of 5 cytokines (IL-1beta, IL-6, TNF-alpha, IFN-gamma and IL-1 receptor antagonist) in sera of newborns during the first 4 weeks of life. At birth, none of the 5 cytokines were detected in almost all serum samples, but the cytokines became detectable within 12 hr after being fed colostram. The mean concentrations of the cytokines reached peak levels by 24 hr and then gradually decreased and became undetectable by 4 weeks after birth. Cytokine mRNA expressions in peripheral blood mononuclear cells of newborns were observed without reference to the cytokine concentrations in sera. Serum cytokines detected in newborn calves are probably colostral origin.
authors.affiliation: Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
authors.forename: Hitoki
authors.initials: H
authors.lastname: Yamanaka
authors.forename: Katsuro
authors.initials: K
authors.lastname: Hagiwara
authors.forename: Rikio
authors.initials: R
authors.lastname: Kirisawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwai
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002417:Cattle / Q000097:blood* / Q000235:genetics; D003126:Colostrum; D016207:Cytokines / Q000097:blood* / Q000235:genetics; D004032:Diet; D005786:Gene Expression Regulation; D012333:RNA, Messenger / Q000097:blood / Q000378:metabolism
chemical_list: D016207:Cytokines; D012333:RNA, Messenger