Digestion and absorption of ferulic acid sugar esters in rat gastrointestinal tract.
We estimated the absorption site and absorptivity of ferulic acid (FA) and its sugar esters, namely 5-O-feruloyl-l-arabinofuranose (FAA) and feruloyl-arabinoxylan (FAXn), in rats on the basis of their recovery in intestinal content and feces by comparing the values with those of a nonabsorbable marker, poly R-478. The results indicated that free FA was absorbed almost completely before reaching cecum. About 40% of dietary FAA was absorbed in rat foregut and 57% disappeared in the cecum. In contrast, about 67% of the FA moiety in FAXn was released and then disappeared predominantly in the hindgut. These results suggested that the existing form of FA in diets affects its absorptivity, its absorption site, and its ensuing fate in the gastrointestinal tract. Those ingested FAs esterified with saccharides; especially, polysaccharides have to transit the hindgut where FA might be released and then absorbed and/or degraded by microflora in lumen. Such microbial degradation may be an important factor affecting the bioavailability of dietary FA.
Zhao
Zhaohui
Z
Laboratory of Food and Nutrition, Graduate School of Science and Technology, Chiba University, 648 Matsudo, Matsudo, Chiba 271-8510, Japan. zhaohuizhao@hotmail.com
Egashira
Yukari
Y
Sanada
Hiroo
H
D000818:Animals; D001089:Arabinose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D001682:Biological Availability; D003373:Coumaric Acids / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D004032:Diet; D004063:Digestion; D004064:Digestive System / Q000737:chemistry; D005243:Feces / Q000737:chemistry; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain; D014990:Xylans / Q000737:chemistry / Q000493:pharmacokinetics
D003373:Coumaric Acids; D014990:Xylans; C431714:arabinofuranose; C085118:arabinoxylan; C004999:ferulic acid; D001089:Arabinose