Pseudoneoplastic appearance of cytomegalovirus-associated colitis in nonimmunocompromised patients: report of 2 cases.
Two cases of human cytomegalovirus (HCMV) colitis with pseudoneoplastic appearance are described. Patients presented with abdominal pain, fever, and diarrhea. Colonoscopy revealed a stenosing lesion in one patient and a broad-based, vegetant mass in the other patient, and histopathological examination of colectomy specimens revealed exuberant inflammatory masses with infiltration of mononuclear cells and ulcers with granulation tissue. Typical intranuclear HCMV inclusions were numerous. Peculiar to both patients was the lack of any apparent causes of immunodeficiency, such as human immunodeficiency virus infection or previous organ transplantation.
Maiorana
Antonio
A
Dipartimento di Anatomia Patologica e Medicina Legale, Universita' di Modena e Reggio Emilia, Modena, Italy. maiorana.antonio@unimo.it
Torricelli
Pietro
P
Giusti
Federica
F
Bellini
Nicola
N
D000368:Aged; D000369:Aged, 80 and over; D003092:Colitis / Q000821:virology*; D003110:Colonic Neoplasms / Q000821:virology*; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000821:virology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008297:Male