title: Tumor recurrence and its timing following curative resection of early gastric carcinoma.
abstract: BACKGROUND
  Although the prognosis of patients with early gastric carcinoma has improved, we still sometimes encounter recurrences following curative resection. Which carcinomas will recur and when a patient will die of recurrence are difficult to predict.
  
  
  METHODS
  We retrospectively analyzed clinicopathological findings in 552 patients with early gastric carcinoma in terms of predicting recurrent cases and postoperative intervals to death from tumor recurrence. Predictive factors for postoperative recurrence were examined by multivariate analysis.
  
  
  CONCLUSIONS
  Patients developing recurrence were significantly older, and regional lymph node metastasis, lymphatic invasion and limited surgery were significantly more frequent. Two-thirds of patients who died of tumor recurrence survived more than 2 years after gastrectomy. The predictive factors for recurrence of early gastric carcinoma were regional lymph node metastasis, limited lymphadectomy and invasion of carcinoma into the submucosa. Extended radical lymphadectomy with gastrectomy and long-term intensive follow-up are needed for patients showing these factors.
authors.affiliation: Department of Surgery, Kyoto Prefectural University of Medicine, Kawaramachi, Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. otsuji@koto.kpu-m.ac.jp
authors.forename: Eigo
authors.initials: E
authors.lastname: Otsuji
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kuriu
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ichikawa
authors.forename: Kazuma
authors.initials: K
authors.lastname: Okamoto
authors.forename: Akeo
authors.initials: A
authors.lastname: Hagiwara
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Yamagishi
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery*; D013997:Time Factors