Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women.
OBJECTIVE
The purpose of this study was to determine changes in adiponectin levels with moderate weight loss, weight loss plus aerobic exercise, or weight loss plus resistive exercise in overweight and obese, sedentary postmenopausal women.


METHODS
Longitudinal, clinical intervention study of 6-month (3 x /week) program of either weight loss (WL, n=15), weight loss + aerobic exercise (WL+AEX, n=16), or weight loss + resistive exercise (WL+RT, n=9)


METHODS
We studied 40 sedentary, overweight and obese (body mass index, BMI=32+/-1 kg/m(2), X+/-s.e.m.) postmenopausal (57+/-1y) women.


METHODS
Fat mass and fat-free mass (FFM) by dual-energy X-ray absorptiometry, plasma insulin, leptin, and adiponectin by radioimmunoassay.


RESULTS
Age, body weight, BMI, waist and hip circumferences, waist-to-hip ratio, VO(2)max, percent fat, total body fat mass, FFM, and fasting plasma glucose, insulin, leptin, and adiponectin concentrations were similar among WL, WL+AEX, and WL+RT groups before the interventions. In all women combined, body weight, BMI, and waist and hip circumferences decreased (P < 0.001). There was a significant absolute decrease in percent body fat from 47 to 44%, representing a 13% decrease in total fat mass and a -1.6% change in FFM. Fasting concentrations of plasma adiponectin did not change (40+/-16%, P=NS), whereas fasting plasma glucose, insulin, and leptin all decreased (P<0.001).


CONCLUSIONS
Plasma adiponectin levels do not change with a 6-month moderate weight reduction program even when accompanied by aerobic or resistive exercise training in overweight and obese postmenopausal women.
Ryan
A S
AS
Department of Medicine, Division of Gerontology at the University of Maryland School of Medicine, Baltimore, MD 21201, USA. aryan@grecc.umaryland.edu
Nicklas
B J
BJ
Berman
D M
DM
Elahi
D
D
D052242:Adiponectin; D000273:Adipose Tissue / Q000503:physiopathology; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin / Q000097:blood; D008137:Longitudinal Studies; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology; D009765:Obesity / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D017698:Postmenopause / Q000097:blood* / Q000502:physiology; D011506:Proteins / Q000032:analysis*; D015431:Weight Loss / Q000502:physiology*
D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D011506:Proteins