Micelles from polyethylene glycol/phosphatidylethanolamine conjugates for tumor drug delivery.
Micelles prepared from polyethylene glycols of various lengths conjugated with phosphatidylethanolamine (PEG-PE) were loaded with various poorly soluble anticancer agents. PEG-PE micelles selectively accumulated in Lewis lung carcinoma (LLC) tumors implanted in mice. Modification of the micelles with tumor specific antibodies further enhanced the efficiency of tumor accumulation.
Lukyanov
Anatoly N
AN
Department of Pharmaceutical Sciences, Bouve College of Health Sciences, 312 Mugar Bldg., Northeastern University, Boston, MA 02115, USA. a.lukyanov@nea.edu
Gao
Zhonggao
Z
Torchilin
Vladimir P
VP
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D004797:Enzyme-Linked Immunosorbent Assay; D005079:Excipients; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008823:Micelles; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010316:Particle Size; D010714:Phosphatidylethanolamines; D011092:Polyethylene Glycols; D012995:Solubility
D000970:Antineoplastic Agents; D005079:Excipients; D008823:Micelles; D010714:Phosphatidylethanolamines; D011092:Polyethylene Glycols