title: Progressive dysgraphia in a case of posterior cortical atrophy.
abstract: Dysgraphia (agraphia) is a common feature of posterior cortical atrophy (PCA). However, detailed analyses of these spelling and writing impairments are infrequently conducted. LM is a 59-year-old woman with dysgraphia associated with PCA. She presented with a two-year history of decline in her writing and dressmaking skills. A 3D T1-weighted MRI scan confirmed selective bi-parietal atrophy, with relative sparing of the hippocampi and other cortical regions. Analyses of LM's preserved and impaired spelling abilities indicated mild physical letter distortions and a significant spelling deficit characterised by letter substitutions, insertions, omissions, and transpositions that was systematically sensitive to word length while insensitive to real word versus nonword category, word frequency, regularity, imagery, grammatical class and ambiguity. Our findings suggest a primary graphemic buffer disorder underlies LM's spelling errors, possibly originating from disruption to the operation of a fronto-parietal network implicated in verbal working memory.
authors.affiliation: Centre for Magnetic Resonance, University of Queensland, Brisbane, Australia. brona.odowd@cmr.uq.edu.au
authors.forename: B S
authors.initials: BS
authors.lastname: O'Dowd
authors.forename: G I
authors.initials: GI
authors.lastname: de Zubicaray
mesh_terms: D000381:Agraphia / Q000209:etiology* / Q000523:psychology; D001284:Atrophy; D018450:Disease Progression; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008568:Memory; D008875:Middle Aged; D010296:Parietal Lobe / Q000473:pathology*