[Transdermal delivery of insulin].
A possibility is studied of the transdermal delivery of insulin by using a mixture of synthetic analogues of phosphoglycerides (SAP), as a potential activator of hormone diffusion, through the skin. Experimentally in vitro, it was proven that the diffusion of insulin through the skin of two types of transdermal therapeutic form (TTF)--matrix-type and matrix-hydrogel-type--is possible only in presence of activator SAP-M-99. The detected optimal composition of insulin matrix TTF with the area of 40 sq cm enabled a trandermal hormone diffusion speed of 0.26 UNITS/h, which is compatible with the secretion of insulin by the pancreas of an adult (0.25-1.5 UNITS/h). A change-over for the matrix-hydrogel system of insulin delivery based on a 40 sq cm collagenous sponge enabled to increase the insulin diffusion up to 0.54 UNITS/h.
Sevast'ianov
V I
VI
Salomatina
L A
LA
Kuznetsova
E G
EG
Iakovleva
N V
NV
Shumakov
V I
VI
D000269:Adhesives; D000277:Adjuvants, Pharmaceutic; D000279:Administration, Cutaneous; D000818:Animals; D004058:Diffusion; D016503:Drug Delivery Systems / Q000379:methods*; D005240:Feasibility Studies; D020404:Glycerophospholipids / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D020100:Hydrogels; D007328:Insulin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011817:Rabbits; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D013552:Swine
D000269:Adhesives; D000277:Adjuvants, Pharmaceutic; D020404:Glycerophospholipids; D020100:Hydrogels; D007328:Insulin