title: Recalcitrant oral pyoderma gangrenosum in a child responsive to cyclosporine.
abstract: We report a case of recalcitrant pyoderma gangrenosum which developed on the tongue of an 8-year-old, previously healthy boy without any systemic associated disease. The lesion was confined to the tongue and was not responsive to conventional treatment with prednisolone and sulfa drug, but it showed dramatic improvement with oral cyclosporine therapy. In addition, the histopathology of the lesion included many eosinophils, which caused difficulties in diagnosis to differentiate this condition from other oral ulcerative diseases showing tissue eosinophilia including eosinophilic ulcer of the tongue.
authors.affiliation: Department of Dermatology, College of Medicine, Dankook University, Korea.
authors.forename: Hyang-Joon
authors.initials: HJ
authors.lastname: Park
authors.forename: Bong-Gyun
authors.initials: BG
authors.lastname: Han
authors.forename: You-Chan
authors.initials: YC
authors.lastname: Kim
authors.forename: Yong-Woo
authors.initials: YW
authors.lastname: Cinn
mesh_terms: D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D017511:Pyoderma Gangrenosum / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine