title: Neurophysiological changes in demyelinating and axonal forms of acute experimental autoimmune neuritis in the Lewis rat.
abstract: Myelin-sensitized T- and B-cells (lymph node cells) induced experimental autoimmune neuritis (EAN) in Lewis rats after passive transfer to naive recipients. After 6 days, all recipient rats developed tail paresis that progressed to limb paresis within 12-72 h. Progressive nerve conduction changes consistent with demyelination in the sciatic nerve (conduction block and prolongation of the distal motor latencies) and lumbar nerve roots (initial low F-wave frequencies followed by later prolongation in F-wave latencies) were observed during the disease. For comparison, adoptive transfer experimental autoimmune neuritis (AT-EAN) of differing disease severity was induced by titrating the dose of P2-specific T-cells. In contrast to EAN induced by myelin-sensitized T- and B-cells, AT-EAN was predominantly associated with rapid nerve conduction changes consistent with axonal dysfunction and degeneration. These findings demonstrate that distinct forms of EAN with different pathophysiological mechanisms are induced by the passive transfer of P2-specific T-cell lines or myelin-specific T-cells and B-cells. The electrophysiological changes in EAN induced by myelin-specific T- and B-cells are very similar to those seen clinically during acute inflammatory demyelinating polyneuropathy, whereas AT-EAN has less resemblance to axonal forms of Guillain-Barré syndrome.
authors.affiliation: Department of Medicine, University of Sydney, Sydney, NSW 2006, Australia. jtaylor@med.usyd.edu.au
authors.forename: Jude M
authors.initials: JM
authors.lastname: Taylor
authors.forename: John D
authors.initials: JD
authors.lastname: Pollard
mesh_terms: D000200:Action Potentials / Q000276:immunology; D019264:Adoptive Transfer; D000818:Animals; D001369:Axons / Q000276:immunology / Q000473:pathology; D001402:B-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D004195:Disease Models, Animal; D018450:Disease Progression; D005073:Evoked Potentials, Somatosensory / Q000276:immunology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology; D009186:Myelin Sheath / Q000276:immunology / Q000473:pathology; D009431:Neural Conduction / Q000276:immunology; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014855:Wallerian Degeneration / Q000276:immunology / Q000473:pathology / Q000503:physiopathology