Effects of L-tetrahydropalmatine on energy metabolism, endothelin-1 and NO during acute cerebral ischemia-reperfusion of rats.
To investigate the effects of L-tetrahydropalmatine (L-THP) on energy metabolism, endothelin-1 (ET-1) and NO during acute cerebral ischemia-reperfusion of rats, 24 Wistar rats were randomly divided into four groups, with 6 rats in each group: sham-operation group, simple ischemia group, ischemia-reperfusion group and treatment group (L-THP group). Cerebral ATP, lactate, ET-1 and NO levels were measured in all groups. Our results showed that treatment with L-THP could increase cerebral ATP levels, but decrease cerebral lactate, ET-1 and NO concentrations during ischemia-reperfusion in the treatment group. It is concluded that L-THP could improve cerebral energy metabolism and protect the injured brain tissue, the mechanism of which might be related to suppression of overproduction of ET-1 and NO.
Yang
G
G
Department of Emergency, Tongji Hospital, Tongji Medical University, Wuhan 430030.
Wang
P
P
Tang
Y
Y
Jiang
C
C
Wang
D
D
D000818:Animals; D001600:Berberine Alkaloids / Q000494:pharmacology*; D002545:Brain Ischemia / Q000378:metabolism*; D016022:Case-Control Studies; D019332:Endothelin-1 / Q000378:metabolism*; D004734:Energy Metabolism; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury
D001600:Berberine Alkaloids; D019332:Endothelin-1; D009569:Nitric Oxide; C014215:tetrahydropalmatine