title: Comparison of positive end-expiratory pressure with reverse Trendelenburg position in morbidly obese patients undergoing bariatric surgery: effects on hemodynamics and pulmonary gas exchange.
abstract: BACKGROUND
  Anesthetized morbidly obese patients often exhibit impaired pulmonary gas exchanges, mostly because of a reduction in functional residual capacity. At present, several approaches are suggested to ventilate these patients.
  
  
  METHODS
  The efficiency of positive end-expiratory pressure (PEEP) and reverse Trendelenburg position (RTP) were compared in order to improve oxygenation in 20 morbidly obese patients undergoing bariatric surgery.
  
  
  RESULTS
  Both PEEP and RTP determined a significant decrease in alveolar-arterial oxygen difference and an increase in total respiratory compliance (Ctot). RTP resulted in lower airway pressures than PEEP with similar improvements in Ctot and oxygenation. Concerning hemodynamic parameters, cardiac output (CO) significantly decreased with both PEEP and RTP.
  
  
  CONCLUSIONS
  RTP and PEEP can be considered adequate ventilatory settings for morbidly obese patients, without any significant difference with regard to gas exchange improvement. However, the decrease in CO may partially counteract the beneficial effects on oxygenation of these ventilatory settings.
authors.affiliation: Department of Anesthesiology and Intensive Care, Catholic University of Sacred Heart, Rome, Italy. perilli.v@libero.it
authors.forename: V
authors.initials: V
authors.lastname: Perilli
authors.forename: L
authors.initials: L
authors.lastname: Sollazzi
authors.forename: C
authors.initials: C
authors.lastname: Modesti
authors.forename: M G
authors.initials: MG
authors.lastname: Annetta
authors.forename: T
authors.initials: T
authors.lastname: Sacco
authors.forename: M G
authors.initials: MG
authors.lastname: Bocci
authors.forename: R M
authors.initials: RM
authors.lastname: Tacchino
authors.forename: R
authors.initials: R
authors.lastname: Proietti
mesh_terms: D000328:Adult; D000758:Anesthesia / Q000009:adverse effects; D015904:Biliopancreatic Diversion; D005260:Female; D018475:Head-Down Tilt / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000503:physiopathology* / Q000601:surgery*; D011175:Positive-Pressure Respiration; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000209:etiology / Q000503:physiopathology / Q000628:therapy