title: Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer.
abstract: The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population-dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within a Japanese population. Fifty-seven women with HPV16-positive cervical cancer were analyzed for E6 sequence variation and its relationship to HLA class II alleles. Compared with local controls (n = 138) and published controls (n = 916), DRB1*1501 and DQB1*0602 frequencies were significantly increased among patients with HPV16 E6 prototype (n = 11). Additionally, DRB1*1502 was positively associated with a particular E6 variant designated D25E (n = 25), although we could not find a significant association between HLA class II alleles and L83V variants (n = 16). Our observations suggest that a specific match between E6 variant proteins and HLA types may contribute to HPV16-related cervical carcinogenesis.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan. matsumok@mui.biglobe.ne.jp
authors.forename: Koji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Yasugi
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Okubo
authors.forename: Ranko
authors.initials: R
authors.lastname: Hirata
authors.forename: Hiroo
authors.initials: H
authors.lastname: Maeda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Taketani
mesh_terms: D002278:Carcinoma in Situ / Q000453:epidemiology / Q000378:metabolism / Q000821:virology; D016022:Case-Control Studies; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005802:Genes, MHC Class II; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D009154:Mutation / Q000235:genetics*; D009361:Neoplasm Invasiveness; D009856:Oncogene Proteins, Viral / Q000145:classification / Q000235:genetics*; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology; D011110:Polymorphism, Genetic; D012097:Repressor Proteins; D012307:Risk Factors; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014412:Tumor Virus Infections / Q000150:complications / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000378:metabolism / Q000821:virology*
chemical_list: D004279:DNA, Viral; C068651:E6 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; D012097:Repressor Proteins