Effect of antibodies to histamine in ultralow doses on production of allergen-specific antibodies.
We studied the effects of potentiated antibodies to histamine on production of IgE and IgG1 in response to 3-fold immunization of mice with ovalbumin in doses of 0.5, 10, and 100 microg. The course of treatment with antibodies to histamine suppressed production of allergen-specific IgE and IgG1 in mice 2-fold immunized with ovalbumin in doses of 100 and 0.5 microg, respectively. In mice immunized 3 times with ovalbumin in various doses the preparation suppressed production of IgE and IgG1.
Agafonov
V I
VI
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Bel'skaya
N V
NV
Danilets
M G
MG
Bel'skii
Yu B
YB
Trofimova
E S
ES
Dugina
Yu L
YL
Epstein
O I
OI
D000485:Allergens / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000276:immunology*; D007110:Immunity, Active / Q000187:drug effects*; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007136:Immunoglobulins / Q000097:blood* / Q000276:immunology; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D051381:Rats
D000485:Allergens; D000906:Antibodies; D007074:Immunoglobulin G; D007136:Immunoglobulins; D007073:Immunoglobulin E; D006632:Histamine; D010047:Ovalbumin