[Role of reactive oxygen species in functional activity of neurons].
The review covers participation of reactive oxygen species (ROS) in the metabolism of neuronal cells, their detrimental action on proteins, lipids and nucleic acids. Oxidative stress is associated with imbalance of ROS generation and dissipation that results in increase in ROS stationary level in the cells. Under normal conditions, ROS become involved in implementation of signal transduction, mechanisms ensuring metabolic response of cells to the external factors.
Boldyrev
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International Biotechnological Center, V.V. Lomonosov Moscow State University, Department of Biochemistry, Moscow.
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D050356:Lipid Metabolism; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D009696:Nucleic Acids / Q000378:metabolism; D018384:Oxidative Stress; D011506:Proteins / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1
D000975:Antioxidants; D009696:Nucleic Acids; D011506:Proteins; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1