Biological activity of serotonin conjugates from the seeds of Centaurea nigra.
Two serotonin conjugates, N-(trans-p-coumaroyl)-serotonin (1) and N-(trans-feruloyl)-serotonin (maoschamine, 2), isolated from the methanol extract of the seeds of Centaurea nigra, have been assessed for antibacterial and free radical scavenging activities. The general toxicity of 1 and 2 has also been determined by the brine shrimp lethality bioassay.
Kumarasamy
Y
Y
Phytopharmaceutical Research Laboratory, School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen, AB10 1FR, Scotland, UK.
Middleton
M
M
Reid
R G
RG
Nahar
L
L
Sarker
S D
SD
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001156:Artemia / Q000187:drug effects; D031179:Centaurea; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012639:Seeds; D012701:Serotonin / Q000737:chemistry
D000900:Anti-Bacterial Agents; D016166:Free Radical Scavengers; D010936:Plant Extracts; D012701:Serotonin