Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus.
Six lanostane-type triterpene acids were isolated from the fruiting bodies of Piptoporus betulinus. They were identified as polyporenic acids A (1) and C (2), three derivatives of polyporenic acid A (3-5), and a novel compound, (+)-12 alpha,28-dihydroxy-3 alpha-(3'-hydroxy-3'-methylglutaryloxy)-24-methyllanosta-8,24(31)-dien-26-oic acid (6). All these compounds suppressed the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced edema on mouse ears by 49-86% with a 400 nmol/ear application.
Kamo
Tsunashi
T
Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, 8304 Minami-minowa, Kami-ina, Nagano 399-4598, Japan.
Asanoma
Masashi
M
Shibata
Hisao
H
Hirota
Mitsuru
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004423:Ear; D004487:Edema; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008745:Methylation; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011124:Polyporaceae / Q000737:chemistry*; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D014315:Triterpenes; D007810:Lanosterol