[The antiarrhythmic activity of the trimecain ammonium derivative in myocardial ischemia].
The results of experiments on cats and dogs showed that quaternidine, a quaternary ammonium derivative of trimecaine, exceeds the structural precursors (trimecaine and lidocaine), as well as the reference drugs quinidine and propranolol, in intensity of the antiarrhythmic action upon single administration on the occlusive and reperfusive arrhythmia models. The therapeutic effect of quaternidine in animals with acute myocardial ischemia lasts for about 8 h, which more than 20 times longer as compared to the duration of action of both lidocaine and trimecaine.
Kostin
Ia V
IaV
Department of Pharmacology, Mordvinian State University, ul. Bol'shevistskaya 68, Saransk, Mordvinia, 430000 Russia.
Blinov
D S
DS
Moiseeva
I Ia
IIa
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D002415:Cats; D004285:Dogs; D017202:Myocardial Ischemia / Q000150:complications*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D014288:Trimecaine / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000889:Anti-Arrhythmia Agents; D000644:Quaternary Ammonium Compounds; D014288:Trimecaine