[Immaturity or hypotrophy? The cord blood leptin levels in preterm and small-for-gestational age neonates].
OBJECTIVE
To assess cord blood leptin levels in preterm and small-for-gestational age neonates and determine whether fetal leptin levels correlate with selected clinical parameters associated with prematurity and undernutrition at birth.


METHODS
Study of preterm newborns (p-AGA; n = 31) and small-for-gestational age (t-SGA; n = 23) cases in a population of neonates born in Szczecin between September 2001 and June 2002.


METHODS
Fetal cord blood was sampled after delivery. Leptin levels were measured by RIA. Anthropometric data (birth weight, birth length, head and chest circumferences, body mass index, Ponderal index) were also recorded.


RESULTS
Cord blood leptin levels did not differ significantly between p-AGA and t-SGA neonates with similar birthweight. Among the two groups of newborns the correlations between fetal leptin and anthropometric data were only observed in p-AGAs, but not in t-SGA group.


CONCLUSIONS
We suggest that cord blood leptin level depends on body mass rather than maturity of newborn. It is also hypothesized that leptin level in SGA neonates is determined by other than anthropometric parameters used in this study.
Garanty-Bogacka
Barbara
B
Samodzielnej Pracownii Propedeutyki Chorób Dzieci Katedry Chorób Dzieci PAM, Szczecinie.
Czeszyńska
Maria Beata
MB
Syrenicz
Małgorzata
M
Gebala
Aneta
A
Kordek
Agnieszka
A
Janus
Dorota
D
Walczak
Mieczysław
M
Krupa
Beata
B
Szołomicka-Kurzawa
Paula
P
Czajka
Ryszard
R
D001724:Birth Weight; D015992:Body Mass Index; D005314:Embryonic and Fetal Development; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007234:Infant, Premature / Q000097:blood*; D007236:Infant, Small for Gestational Age / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D015999:Multivariate Analysis; D011247:Pregnancy
D020738:Leptin