[Lipid peroxidation in the pathogenesis of primary open-angle glaucoma].
19 tissue samplings of the iris and trabecula from 17 patients, aged 49 to 79, with primary open-angle glaucoma (POAG) of different stages were examined for the purpose of studying the condition of lipid membranes in the iridial and trabecular tissues by electron microscopy. The results are indicative of that the key role, in the POAG pathogenesis, belongs to lipid peroxidation of posterior and anterior leaves of the retinal pigment epithelium, which is an activator of apoptotic processes in the trabecular endothelium. Therefore, it is advisable to use the lipid- and water-soluble antioxidative drugs to correct the physiological antioxidative deficiency within a complex POAG treatment.
Ziangirova
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Antonova
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000627:therapeutic use; D017209:Apoptosis; D003593:Cytoplasm / Q000378:metabolism; D004727:Endothelium / Q000378:metabolism / Q000648:ultrastructure; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007498:Iris / Q000378:metabolism / Q000648:ultrastructure; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008544:Melanocytes / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism; D008854:Microscopy, Electron; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism; D010857:Pigment Epithelium of Eye / Q000378:metabolism / Q000648:ultrastructure; D014129:Trabecular Meshwork / Q000378:metabolism / Q000648:ultrastructure
D000975:Antioxidants; D008563:Membrane Lipids