[Determination of sulfamethoxazole in compound sulfamethoxazole tablet by first derivative ratio spectrometry].
The first derivative ratio spectrometry is used for the determination of sulfamethoxazole in compound sulfamethoxazole tablet. According to the first derivative ratio spectrum of sulfamethoxazole, peak-zero method is applied for the determination at 251 nm. There is a good linear correlation between the first derivative ratio spectrum value and concentration (1-15 micrograms.mL-1) for the method that can eliminate the disturbance of trimethoprim, and no difference while comparing the method with pharmacopoeia method (P > 0.05).
Sun
Z
Z
No. 1 Hospital of Lianyungang, Jiangsu, Lianyungang 222002.
Li
R
R
Li
Y
Y
Wang
K
K
Zhang
Q
Q
Zhou
J
J
D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013420:Sulfamethoxazole / Q000032:analysis*; D013607:Tablets; D014295:Trimethoprim / Q000032:analysis; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000737:chemistry*
D013607:Tablets; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole