A cyclic carbonate and related polyketides from a marine-derived fungus of the genus Phoma.
Two metabolites, phomoxin and phomoxide, as well as the previously synthesized antibiotic eupenoxide, have been isolated from the fermentation broth of a marine-derived fungus of the genus Phoma (strain CNC-651). The new compounds are highly oxygenated polyketides of a new structural class. Phomoxin contains an unusual cyclic carbonate functionality that is rare among natural products. The structures of the new metabolites were assigned by spectroscopic methods that relied heavily on 2D NMR spectroscopic analysis.
Liu
Zimin
Z
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA.
Jensen
Paul R
PR
Fenical
William
W
D002254:Carbonates / Q000737:chemistry* / Q000302:isolation & purification*; D005285:Fermentation; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D013098:Xylariales / Q000737:chemistry*
D002254:Carbonates; D018942:Macrolides