title: Mapping the kinase domain of Janus Kinase 3.
abstract: The utilization and impact of parallel synthesis on lead exploration around initial hit oxindole (1) are described. The emergent SAR, analogue design and functional impact will also be detailed.
authors.affiliation: Aventis Pharmaceuticals, 1041 Route 202-206, PO Box 6800, Bridgewater, NJ 08807, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Adams
authors.forename: David J
authors.initials: DJ
authors.lastname: Aldous
authors.forename: Shelley
authors.initials: S
authors.lastname: Amendola
authors.forename: Paul
authors.initials: P
authors.lastname: Bamborough
authors.forename: Colin
authors.initials: C
authors.lastname: Bright
authors.forename: Sarah
authors.initials: S
authors.lastname: Crowe
authors.forename: Paul
authors.initials: P
authors.lastname: Eastwood
authors.forename: Garry
authors.initials: G
authors.lastname: Fenton
authors.forename: Martyn
authors.initials: M
authors.lastname: Foster
authors.forename: Trevor K P
authors.initials: TK
authors.lastname: Harrison
authors.forename: Sue
authors.initials: S
authors.lastname: King
authors.forename: Justine
authors.initials: J
authors.lastname: Lai
authors.forename: Christopher
authors.initials: C
authors.lastname: Lawrence
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Letallec
authors.forename: Clive
authors.initials: C
authors.lastname: McCarthy
authors.forename: Neil
authors.initials: N
authors.lastname: Moorcroft
authors.forename: Kenneth
authors.initials: K
authors.lastname: Page
authors.forename: Sudha
authors.initials: S
authors.lastname: Rao
authors.forename: Jane
authors.initials: J
authors.lastname: Redford
authors.forename: Shazia
authors.initials: S
authors.lastname: Sadiq
authors.forename: Keith
authors.initials: K
authors.lastname: Smith
authors.forename: John E
authors.initials: JE
authors.lastname: Souness
authors.forename: Sukanthini
authors.initials: S
authors.lastname: Thurairatnam
authors.forename: Mark
authors.initials: M
authors.lastname: Vine
authors.forename: Barry
authors.initials: B
authors.lastname: Wyman
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry*; D000818:Animals; D001665:Binding Sites; D002455:Cell Division / Q000187:drug effects; D015195:Drug Design; D004487:Edema / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000737:chemistry; D007211:Indoles / Q000737:chemistry; D020128:Inhibitory Concentration 50; D007376:Interleukin-2 / Q000494:pharmacology; D053616:Janus Kinase 3; D051379:Mice; D015125:Oxyquinoline / Q000737:chemistry; D010766:Phosphorylation / Q000187:drug effects; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011505:Protein-Tyrosine Kinases / Q000737:chemistry* / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000276:Adjuvants, Immunologic; D004791:Enzyme Inhibitors; D007211:Indoles; D007376:Interleukin-2; D015125:Oxyquinoline; D011505:Protein-Tyrosine Kinases; C507935:Jak3 protein, mouse; D053616:Janus Kinase 3