Blood-gas and acid-base profile in dogs with severe pancreatitis.
A number of systemic disorders develop in the clinical course of acute pancreatitis. Among these important are the respiratory disorders occurring in 35-55% of the patients. They develop in the first hours after onset of pancreatitis and are the cause of death in 60% of the severe forms of acute pancreatitis. We studied the changes in the arterial blood oxygen status and acid-base status in experimentally induced severe acute pancreatitis in dogs. The animals were divided into two groups--one receiving sandostatin treatment and the other without treatment. Quickly progressing acute arterial hypoxemia was observed in the dogs with severe acute pancreatitis. Hypoxemia development was delayed by administration of sandostatin.
Uchikov
Angel P
AP
Clinic of Thoracic and Abdominal Surgery, University Hospital St. George, Plovdiv, Bulgaria.
Nedev
Petko I
PI
Shipkov
Hristo D
HD
Markova
Desislava M
DM
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D001784:Blood Gas Analysis; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D006728:Hormones / Q000494:pharmacology; D008297:Male; D015282:Octreotide / Q000494:pharmacology; D010100:Oxygen / Q000097:blood*; D019283:Pancreatitis, Acute Necrotizing / Q000188:drug therapy / Q000662:veterinary*
D006728:Hormones; D015282:Octreotide; D010100:Oxygen