Synthesis and biological evaluation of cytostatin analogues.
Analogues of the serine/threonine phosphatase 2A inhibitor cytostatin were synthesized and evaluated as inhibitors of various phosphatases in order to establish a basic structure-activity relationship (SAR) of the natural product.
Bialy
Laurent
L
Max-Planck-Institut für molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Str. 11, 44227 Dortmund, Germany.
Waldmann
Herbert
H
D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008956:Models, Chemical; D015394:Molecular Structure; D010755:Organophosphates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D054648:Protein Phosphatase 2; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D010755:Organophosphates; D011753:Pyrones; C088526:cytostatin; D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2