title: Genetic variation at the adipsin locus and response to long-term overfeeding.
abstract: OBJECTIVE
  The role of adipsin and adipsin Hinc II polymorphisms on the metabolic and body composition changes in response to overfeeding was studied.
  
  
  METHODS
  A total of 12 pairs of male monozygotic twins ate a 4.2 MJ/day energy surplus, 6 days a week, during a period of 100 days.
  
  
  RESULTS
  The preoverfeeding plasma adipsin concentration correlated positively with the change in CT-measured abdominal total and subcutaneous (P<0.05) fat. The changes in abdominal total fat and abdominal subcutaneous fat correlated negatively with changes in plasma adipsin concentrations (P<0.005). Overfeeding induced greater increases in body weight, fat mass, abdominal total and subcutaneous fat (P<0.05) in 6.1 kb noncarriers (n=10) than in 6.1 kb carriers (n=14) of the adipsin Hinc II polymorphism. The 6.1 kb noncarriers had a greater increase in plasma leptin levels (P<0.01). Also the total (P<0.01) and very-low-density lipoprotein (VLDL)-triglycerides (P<0.05), apolipoprotein B (P<0.05) and VLDL-cholesterol (P<0.05) levels increased more in the 6.1 kb noncarriers than in the 6.1 kb carriers.
  
  
  CONCLUSIONS
  Adipsin plasma level could be a predictor of the changes in abdominal subcutaneous fat during times of increased energy intake. However, a greater increase in the abdominal subcutaneous fat was related to a lower increase in the plasma adipsin level. The adipsin Hinc II 6.1 kb allele noncarriers gained more abdominal subcutaneous fat and had a greater increase in plasma levels of leptin- and triglyceride-rich lipoproteins when exposed to a long-term positive energy balance. These findings provide new information on the role of adipsin on individual differences in response to chronically elevated food intake.
authors.affiliation: Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland.
authors.forename: O
authors.initials: O
authors.lastname: Ukkola
authors.forename: M
authors.initials: M
authors.lastname: Chagnon
authors.forename: A
authors.initials: A
authors.lastname: Tremblay
authors.forename: C
authors.initials: C
authors.lastname: Bouchard
mesh_terms: D000005:Abdomen / Q000502:physiology; D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000502:physiology; D000328:Adult; D015992:Body Mass Index; D011416:Complement Factor D; D005260:Female; D014644:Genetic Variation / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D044343:Overnutrition / Q000097:blood* / Q000235:genetics*; D012697:Serine Endopeptidases / Q000097:blood* / Q000235:genetics*; D012885:Skinfold Thickness; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed; D014430:Twins, Monozygotic
chemical_list: D007328:Insulin; D020738:Leptin; D008055:Lipids; D012697:Serine Endopeptidases; C493488:CFD protein, human; D011416:Complement Factor D