Impaza and sildenafil: comparison of clinical effectiveness in patients with erectile dysfunction.
A blind, placebo-controlled, randomized trial showed clinical effectiveness of the preparation Impaza containing antibodies to endothelial NO synthase in ultralow doses. Impaza surpassed placebo, but was less potent than sildenafil in the ability to improve erectile function and other parameters characterizing sexual activity of men. Safety of Impaza was greater than that of other test preparations.
Petrov
V I
VI
Volgograd Medical Academy.
Vekel'yan
A S
AS
Martyushev
A V
AV
Sergeeva
S A
SA
Smolenov
I V
IV
Epstein
O I
OI
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects / Q000627:therapeutic use*; D011687:Purines / Q000009:adverse effects / Q000627:therapeutic use; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
D000906:Antibodies; C534505:IMPAZA; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate