[Fasting plasma insulin and insulin sensitivity in the offspring of parents with a family hypertensive history].
OBJECTIVE
To investigate the plasma insulin levels and insulin sensitivity in the offspring of parents with family hypertensive history in Tibetan population.


METHODS
Tibetan hypertensive pedigrees and normotensive pedigrees based on a door-to-door cross section study performed from 1997 to 1998 in stable communities in the ruban district of Lhasa city were set up, 47 offsprings from hypertensive pedigrees (group I) and 21 offsprings from normotensive pedigrees (group II) were enrolled into this study. Plasma insulin levels using by radioimmunoassay and insulin sensitivity with the formulae insulin sensitivity = 1/(fasting plasma glucose x fasting plasma insulin) were compared between two groups.


RESULTS
There were no statistically significant differences in fasting blood glucose levels between group I and group II. But fasting plasma insulin level was 10.20 +/- 6.95 m IU/L in group I and 6.56 +/- 2.81 m IU/L in group II, respectively, and there were statistically significant differences between these two groups. The insulin sensitivity index in group I was significantly lower than that in group II (0.036 +/- 0.024 and 0.046 +/- 0.022, respectively).


CONCLUSIONS
Offspring of Tibetan hypertensive pedigrees were observed to be hyperinsulinemia and reduced insulin sensitivity. These metabolic abnormalities may be associated with hypertension and dyslipidemia in adulthood.
Gelsang
Norpu
N
Department of Cardiology, Tibet Autonomous Region People's Hospital, Institute of cardiovascular disease and high altitude sickness, Lhasa 850000, China.
Cen
Wei-jun
WJ
Dronma
Tsering
T
Pingtso
Tashi
T
Chen
Yong
Y
Zhou
Wen-jun
WJ
Liu
Guo-zhang
GZ
D001786:Blood Glucose / Q000032:analysis; D002648:Child; D005215:Fasting; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D018609:Tibet
D001786:Blood Glucose; D007328:Insulin