Linezolid clearance during continuous venovenous hemodiafiltration: a case report.
OBJECTIVE
To determine the linezolid clearance and serum concentrations in a critically ill man receiving continuous venovenous hemodiafiltration (CVVHDF).


METHODS
Intravenous linezolid 600 mg every 12 hours was administered to a critically ill, 85-year-old man with anuria who was receiving CVVHDF at a dialysate flow rate of 2000 ml/hour and a mean ultrafiltrate production rate of 775 ml/hour. Samples of blood and spent dialysate and ultrafiltrate were obtained at the time of linezolid peaks and troughs, and linezolid concentrations were determined.


RESULTS
The CVVHDF yielded a mean linezolid clearance of 36.5 ml/minute and an elimination half-life of 7.5 hours. The linezolid saturation coefficient ranged from 0.77-0.81. Administration of intravenous linezolid 600 mg every 12 hours yielded suitable serum trough concentrations.


CONCLUSIONS
Administration of intravenous linezolid 600 mg every 12 hours maintained therapeutic serum trough concentrations in this critically ill patient receiving CVVHDF.
Kraft
Michael D
MD
Department of Clinical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA. mdkraft@umich.edu
Pasko
Deborah A
DA
DePestel
Daryl D
DD
Ellis
Jessica J
JJ
Peloquin
Charles A
CA
Mueller
Bruce A
BA
D000081:Acetamides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001002:Anuria / Q000628:therapy*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D016638:Critical Illness / Q000628:therapy; D004334:Drug Administration Schedule; D006207:Half-Life; D006440:Hemofiltration; D006801:Humans; D000069349:Linezolid; D008297:Male; D023303:Oxazolidinones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid