[State of the blood phagocytic system in the Nitroblue tetrazolium test conducted in clean-up workers following an extended period of time after the Chernobyl nuclear plant accident].
The functional-and-metabolic status of neutrophil granulocytes was studied in liquidators of consequences of the accident (LCA) at the Chernobyl nuclear power station (CNPS) by using the nitroblue tetrazolium test (NTT). Tests, involving the recovery of nitroblue tetrazolium in both spontaneous and stimulated variants, were made in LCAs and the obtained data were compared with the results of similar tests in the control groups. High NTT parameters were found in spontaneous tests. A lack of the activation in response to zymosan is a specific feature of LCA blood granulocytes. Profound disorders were detected in the phagocyte systems of LCAs, which is indicative of disrupted enzymatic processes in neutrophil granulocytes. On the whole, a sharp functional reduction of neutrophils inhibits their bactericidity. The obtained results were used to work out and to patient "The method of detecting a radioactive irradiation of the body."
Bykova
A A
AA
Sedinina
N S
NS
D000328:Adult; D001770:Blood Bactericidal Activity; D003584:Cytological Techniques; D006801:Humans; D007202:Indicators and Reagents; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology / Q000276:immunology*; D009580:Nitroblue Tetrazolium; D010587:Phagocytosis; D011210:Power Plants; D018788:Radioactive Hazard Release; D013997:Time Factors; D014455:Ukraine
D007202:Indicators and Reagents; D009580:Nitroblue Tetrazolium