Drug-induced stabilisation of a mismatched C-T base pair in a DNA hairpin.
We have shown that a key feature of drug binding, namely specific G-C base pair recognition at a 5'-TG step, can induce a number of novel structural features when an extrahelical base is inserted in close proximity to the drug binding site; we have clearly demonstrated the formation of a stabilised C-T mismatched base pair at a non-terminal site.
Gallagher
Cathal T
CT
School of Chemistry, University Park, Nottingham, UK NG7 2RD.
Searle
Mark S
MS
D020137:Base Pair Mismatch; D004247:DNA / Q000737:chemistry* / Q000187:drug effects / Q000235:genetics; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009621:Nogalamycin / Q000737:chemistry* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D009690:Nucleic Acid Conformation / Q000187:drug effects; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry / Q000187:drug effects / Q000235:genetics
D009692:Nucleic Acid Heteroduplexes; D004247:DNA; D009621:Nogalamycin