Acquired narcolepsy in an acromegalic patient who underwent pituitary irradiation.
The authors report the case of a 60-year-old man with acromegaly, who developed narcolepsy 2 weeks after completing radiotherapy for a pituitary adenoma. Cataplexy and sleepiness were predominant symptoms. Onset of narcolepsy is unusual at this age and the temporal relationship following radiotherapy suggests this treatment was implicated. His CSF hypocretin levels were normal, indicating other factors may be important in his narcolepsy.
Dempsey
Owen J
OJ
Department of Respiratory Medicine, Aberdeen Royal Infirmary, Grampian University Hospital Trust, Aberdeen, Scotland, UK. O.Dempsey@arh.grampian.scot.nhs.uk
McGeoch
Paul
P
de Silva
Rajith N
RN
Douglas
Neil J
NJ
D000172:Acromegaly / Q000532:radiotherapy*; D002352:Carrier Proteins / Q000134:cerebrospinal fluid; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008454:Mazindol / Q000627:therapeutic use; D008875:Middle Aged; D009290:Narcolepsy / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000209:etiology*; D009479:Neuropeptides / Q000134:cerebrospinal fluid; D000068797:Orexins; D010910:Pituitary Irradiation / Q000009:adverse effects*; D011832:Radiation Injuries / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000209:etiology*; D020188:Sleep Paralysis / Q000209:etiology
D002352:Carrier Proteins; D000697:Central Nervous System Stimulants; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins; D008454:Mazindol