[Occult pancreatobiliary reflux and gallbladder carcinoma].
A total of 108 patients with a normal pancreaticobiliary junction who had gallbladder wall thickness as shown by ultrasonography or computed tomography underwent secretin injection magnetic resonance cholangiopancreatography. Based on the changes in the diameter of the biliary system after secretin injection, patients were categorized into the intensified group (n = 19) or the non-intensified group (n = 89). The mean (+/- SD) biliary amylase level in the bile duct was 41674 (+/- 59779) IU/L in the intensified group, which was significantly higher than that in the non-intensified group (210 (+/- 418)) IU/L (p < 0.0001). There were four patients with carcinoma of the gallbladder in the intensified group and their biliary amylase level in the bile duct was 90783 (+/- 82528) IU/L. Pancreatobiliary reflux similar to that seen in patients with pancreaticobiliary maljunction can occur in persons with a normal pancreaticobiliary junction and this may be associated with carcinoma of the gallbladder. Secretin injection magnetic resonance cholangiopancreatography proved useful to identify such persons.
Sai
Jin Kan
JK
Department of Gastroenterology, Juntendo University.
Suyama
Masafumi
M
Kubokawa
Yoshihiro
Y
Tadokoro
Hiroyuki
H
Koshikawa
Hitoshi
H
Ookubo
Hironao
H
Kato
Kei
K
Matsumura
Yuji
Y
Satou
Nobuhiro
N
Kawasaki
Seiji
S
Kojima
Kuniaki
K
Nobukawa
Bunsei
B
Suda
Kouichi
K
Suzuki
Yasushi
Y
Tsushima
Hidefumi
H
Mori
Hideki
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001652:Bile Ducts / Q000473:pathology*; D001655:Bile Reflux / Q000175:diagnosis*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D005260:Female; D005706:Gallbladder Neoplasms / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010183:Pancreatic Ducts / Q000473:pathology*; D012633:Secretin
D012633:Secretin