title: Postural and neurological deficits in broiler chicks after cervical vaccination with live vaccine.
abstract: A disease characterized by paresis and paralysis was seen in 7-9-day-old broiler chicks after vaccination in the neck area at day-of-age with a live virus vaccine containing viruses of Marek's disease, fowl pox, and infectious bursal disease. Affected birds presented with variable signs of ataxia, lateral recumbency, leg paralysis, and twisting or S-shaped flexure of the neck. Gross lesions noted at necropsy included swelling and edema of the subcutaneous tissues and muscles of the neck at the injection site area. A heavy mononuclear inflammatory cell infiltration was seen in the subcutaneous tissues, connective tissues, and muscles of the neck at the injection site. In some cases, the inflammatory process extended along fascial planes to involve the epidural spaces surrounding the spinal cord. Fatty changes with possible demyelination of nerve fibers were noted in some sections of the spinal cord adjacent to the inflammatory lesions. Clusters of poxviruses were found within some inflammatory lesions on transmission electron photomicrographs.
authors.affiliation: From Embrex Inc., 1040 Swabia Court, Research Triangle Park, NC 27709-3989, USA.
authors.forename: C R
authors.initials: CR
authors.lastname: Gustafson
authors.forename: G L
authors.initials: GL
authors.lastname: Cooper
authors.forename: B R
authors.initials: BR
authors.lastname: Charlton
authors.forename: A A
authors.initials: AA
authors.lastname: Bickford
authors.forename: R
authors.initials: R
authors.lastname: Nordhausen
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D018175:Birnaviridae Infections / Q000517:prevention & control / Q000821:virology; D002645:Chickens; D003711:Demyelinating Diseases / Q000209:etiology / Q000662:veterinary; D005586:Fowlpox / Q000517:prevention & control / Q000821:virology; D007249:Inflammation; D008380:Marek Disease / Q000517:prevention & control / Q000821:virology; D009333:Neck; D009422:Nervous System Diseases / Q000209:etiology / Q000662:veterinary*; D011187:Posture; D011201:Poultry Diseases / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination / Q000009:adverse effects* / Q000662:veterinary*; D014765:Viral Vaccines / Q000009:adverse effects*
chemical_list: D014765:Viral Vaccines