Sickle cell crisis and endothelin antagonists.
Sickle cell crisis may be more complex than a vaso-occlusive event in response to hypoxia. Endothelin-1 (ET-1) is a potent vasoconstrictor and mitogen secreted in response to hypoxia. ET-1 contributes to the vaso-occlusion and inflammation in sickle cell crisis. ET-1 antagonists may be useful in the prevention and treatment of crisis.
Angerio
Allan D
AD
School of Nursing and Health Studies, Georgetown University, Washington, DC 20057-1107, USA. angerioa@georgetown.edu
Lee
Nicole D
ND
D000208:Acute Disease; D000755:Anemia, Sickle Cell / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D000077300:Bosentan; D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1 / Q000037:antagonists & inhibitors*; D006801:Humans; D000860:Hypoxia; D010146:Pain / Q000209:etiology; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B; D013449:Sulfonamides / Q000008:administration & dosage*
D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B; D013449:Sulfonamides; D000077300:Bosentan