[The effect of analysed hypotensive drugs on certain metabolic parameters].
The aim of this study was to assess the influence of 3 hypotensive drugs on the metabolic disorders: dyslipidemia, insulin resistance, hyperuricemia. There were 39 patients aged 20-55, with mild-to-moderate essential hypertension. The patients with other serious diseases or treated earlier with cholesterol or uric acid lowering drugs were excluded. Patients were divided into 3 groups, each was treated during 8 weeks with one drug: gr 1--trandolapril (T), gr 2--felodipine ER (F), gr 3--rilmenidine (R). Glucose and insulin in oral glucose tolerance test, I/G proportion, serum lipids and uric acid were tested before and after therapy. The therapy did not influence lipid parameters: LDL, HDL, triglyceride. In the T group there could be observed a significant reduction of total cholesterol value. Examined drugs did not induce changes in serum carbohydrate. The significant reduction of serum uric acid could be observed only after F therapy. Analysed drugs are very useful in therapy of hypertension with metabolic disorders.
Miczke
Anna
A
Katedra i Klinika Chorób Wewnetrznych i Zaburzeń Metabolicznych w Poznaniu.
Pupek-Musialik
Danuta
D
Cymerys
Maciej
M
Bryl
Wiesław
W
Kujawska-Łuczak
Magdalena
M
Bogdański
Paweł
P
D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects*; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced; D015736:Felodipine / Q000009:adverse effects; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced* / Q000453:epidemiology / Q000378:metabolism; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D033461:Hyperuricemia / Q000139:chemically induced*; D007211:Indoles / Q000009:adverse effects; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced*; D008875:Middle Aged; D010080:Oxazoles / Q000009:adverse effects; D000077769:Rilmenidine
D000959:Antihypertensive Agents; D007211:Indoles; D010080:Oxazoles; C052035:trandolapril; D015736:Felodipine; D000077769:Rilmenidine