title: Intraventricular rupture of Nocardia brain abscess--case report.
abstract: A 71-year-old male presented with left hemiparesis and confused conversation. Computed tomography showed a mass lesion with rim enhancement in the right parietal lobe. He developed meningeal irritation the day after admission. Emergent fluid-attenuated inversion recovery (FLAIR) magnetic resonance (MR) imaging revealed a clear hyperintense component in the right lateral ventricle and niveau formation inside the intracerebral lesion, indicating intraventricular rupture of the brain abscess. The patient underwent aspiration of the abscess and ventricular drainage with antibiotic administration. Nocardia asteroides was isolated from the aspirated pus, so systemic and direct administration of effective antibiotics was subsequently commenced. These procedures resulted in gradual improvement of his clinical course, and he left our hospital. Several days after discharge, he developed acute pan-peritonitis due to malignant lymphoma. He appeared to be progressively deteriorating after an exploratory laparotomy, and died on the 17th day after the laparotomy. Intraventricular rupture of nocardia brain abscess can be successfully treated after early definitive diagnosis with FLAIR MR imaging.
authors.affiliation: Department of Neurosurgery, Sasebo Central Hospital, Sasebo, Nagasaki, Japan. oshiro_shinya@hosp.pref.okinawa.jp
authors.forename: Shinya
authors.initials: S
authors.lastname: Oshiro
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Ohnishi
authors.forename: Mika
authors.initials: M
authors.lastname: Ohta
authors.forename: Hirohito
authors.initials: H
authors.lastname: Tsuchimochi
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000368:Aged; D001922:Brain Abscess / Q000175:diagnosis* / Q000382:microbiology* / Q000601:surgery; D015780:Carbapenems / Q000627:therapeutic use; D002552:Cerebral Ventricles; D003221:Confusion / Q000175:diagnosis; D003937:Diagnosis, Differential; D004322:Drainage; D017809:Fatal Outcome; D007839:Functional Laterality; D006801:Humans; D007813:Laparotomy / Q000379:methods; D008223:Lymphoma / Q000150:complications; D008279:Magnetic Resonance Imaging; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000382:microbiology; D019635:Neurosurgical Procedures; D009617:Nocardia Infections / Q000175:diagnosis* / Q000382:microbiology* / Q000601:surgery; D009616:Nocardia asteroides / Q000302:isolation & purification*; D010291:Paresis / Q000175:diagnosis; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D010538:Peritonitis / Q000150:complications / Q000601:surgery; D011859:Radiography; D012422:Rupture, Spontaneous / Q000175:diagnosis / Q000382:microbiology
chemical_list: D015780:Carbapenems