Bioactive flavonoids of Tanacetum parthenium revisited.
Bio-guided fractionation of an extract from Tanacetum parthenium showing activity as mitotic blocker allowed the isolation and identification of santin 3, jaceidin 2 and centaureidin 1. The latter two closely related flavonols, which, to the best of our knowledge, are isolated here together for the first time, form a mixture difficult to resolve and which is probably the reason for the confusion in the literature regarding their occurrence. Centaureidin 1 had an IC50 of 1 microM while jaceidin 2 and santin 3 were 200 times less active.
Long
Christophe
C
UMR CNRS 1973, Institut de Recherche Pierre Fabre, 3 rue Ariane, 31527 Ramonville, France.
Sauleau
Pierre
P
David
Bruno
B
Lavaud
Catherine
C
Cassabois
Valérie
V
Ausseil
Frédéric
F
Massiot
Georges
G
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005591:Chemical Fractionation / Q000379:methods; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008938:Mitosis / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry; D020903:Tanacetum parthenium / Q000737:chemistry*
D000970:Antineoplastic Agents; D005419:Flavonoids; D044948:Flavonols; D010936:Plant Extracts; C104803:santin; C083161:centaureidin