title: Gold coating and restenosis after primary stenting of ostial renal artery stenosis.
abstract: Predictors of restenosis after stent angioplasty of ostial renal artery stenosis (RAS) and long-term technical success, particularly the influence of gold coating, are unknown. During a 4-year period (1996-2000), we treated 156 consecutive patients with 219 ostial RAS of > or = 70% diameter stenosis. Gold-coated stents were used in 29% of RAS (n = 64); the vessel diameter ranged from 3 to 9 mm. The restenosis rate was 11.4% at 12 months, 12.2% for gold-coated stents and 11.1% for noncoated stents. Restenosis rates were 16% for < or = 4 mm, 17% for 5 mm, 10% for 6 mm, and 0% for > or = 7 mm (P < or = 0.05). In a backward stepwise logistic regression analysis including gold coating, vessel diameter, gender, diabetes, smoking status, as well as lesion diameter stenosis before and after stenting, vessel diameter was found the only independent predictor of restenosis (odds ratio = 0.57; 95% CI = 0.35-0.93; P = 0.02, for an increase in vessel diameter of 1 mm). Gold coating was not a significant predictor (odds ratio = 1.09; 95% CI = 0.39-3.03; P = 0.87). Seven major (4.5%) complications occurred. There were no procedural fatalities. The restenosis rate after stent angioplasty of ostial RAS is influenced by the vessel diameter but not by gold coating.
authors.affiliation: Department of Angiology, Herz Zentrum Bad Krozingen, Bad Krozingen, Germany. thomas.zeller@herzzentrum.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Zeller
authors.forename: Christian
authors.initials: C
authors.lastname: Müller
authors.forename: Ulrich
authors.initials: U
authors.lastname: Frank
authors.forename: Karlheinz
authors.initials: K
authors.lastname: Bürgelin
authors.forename: Lutz
authors.initials: L
authors.lastname: Sinn
authors.forename: Barbara
authors.initials: B
authors.lastname: Horn
authors.forename: Helmut
authors.initials: H
authors.lastname: Roskamm
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019917:Blood Vessel Prosthesis Implantation; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006046:Gold / Q000627:therapeutic use*; D006083:Graft Occlusion, Vascular / Q000209:etiology* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012078:Renal Artery Obstruction / Q000401:mortality / Q000601:surgery*; D015607:Stents / Q000009:adverse effects; D016019:Survival Analysis; D013997:Time Factors; D017211:Treatment Failure
chemical_list: D020099:Coated Materials, Biocompatible; D006046:Gold