Experimental membrane-destructive model of cardiac arrhythmia.
We propose a method for experimental modeling of cardiac arrhythmias. The method consists in intravenous injection of LPO inductors: 5% ascorbic acid (50 mg/kg), 1 min later 1% iron sulfate (10 mg/kg), and after the appearance of giant T waves on ECG infusion of 10% calcium chloride in a nonarrhythmogenic dose 100 mg/kg. Cardiac arrhythmias were induced in 100% animals. A significant relationship between increased permeability of erythrocyte membranes and development of fatal cardiac arrhythmias was detected. We assumed that this methodologically simple membrane-destructive model of cardiac arrhythmia is pathogenetically close to arrhythmogenesis in patients with coronary heart disease.
Lipnitskii
T N
TN
Vinnitsa State Medical University.
Kozlovskii
V A
VA
Kutnyak
V P
VP
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D001205:Ascorbic Acid / Q000378:metabolism; D002122:Calcium Chloride / Q000378:metabolism; D002463:Cell Membrane Permeability; D004195:Disease Models, Animal; D004562:Electrocardiography; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D058085:Iron Compounds / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051381:Rats
D000975:Antioxidants; D058085:Iron Compounds; D008315:Malondialdehyde; D002122:Calcium Chloride; D001205:Ascorbic Acid