Genome-wide linkage analysis of serum adiponectin in the Pima Indian population.
Adiponectin is a circulating protein secreted by adipocytes and is thought to have insulin-sensitizing effects. We present genetic analysis of adiponectin levels in 517 Pima Indians without diabetes (from 162 families, 750 sib-pairs). Adiponectin concentrations were heritable, with 39% of the variance of age- and sex-adjusted adiponectin potentially accounted for by additive genetic influences in this population. In genome-wide linkage analyses, suggestive linkage (logarithm of odds [LOD] = 3.0) of adiponectin adjusted for age and sex was found on chromosome 9p at 18 cM. Linkage was also present after inclusion of adiponectin concentrations of siblings with type 2 diabetes not treated pharmacologically (total siblings 582, 182 families, 860 sib-pairs: LOD = 3.5). Tentative evidence of linkage was also found on chromosomes 2 (LOD = 1.7 at 89 cM), 3 (LOD = 1.9 at 124 cM), and 10 (LOD = 1.7 at 70 cM), offering some support to findings of a previous genome-wide scan of adiponectin. Our data suggest that quantitative trait loci on chromosomes 2, 3, 9, and 10 may influence circulating adiponectin concentrations in the Pima population.
Lindsay
Robert S
RS
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA.
Funahashi
Tohru
T
Krakoff
Jonathan
J
Matsuzawa
Yuji
Y
Tanaka
Sachiyo
S
Kobes
Sayuko
S
Bennett
Peter H
PH
Tataranni
P Antonio
PA
Knowler
William C
WC
Hanson
Robert L
RL
D052242:Adiponectin; D000328:Adult; D002879:Chromosomes, Human, Pair 10; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D002899:Chromosomes, Human, Pair 9; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D005260:Female; D015894:Genome, Human; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D036341:Intercellular Signaling Peptides and Proteins; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*
D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins