title: Controlled, randomized trial in maintenance treatment of intravenous buprenorphine dependence with naltrexone, methadone or buprenorphine: a novel study.
abstract: OBJECTIVE
  To test the effect of a 50-mg day-1 dose of naltrexone in the maintenance treatment of intravenous-buprenorphine dependence in comparison with a 50-mg day-1 dose of methadone and also a 5-mg day-1 dose of buprenorphine over a 24-week treatment period.
  
  
  METHODS
  Two hundred and four intravenous-buprenorphine-dependent patients who met the DSM-IV criteria for opioid dependence were randomized to three equal groups and were treated in a clinic in Iran where they were also offered a weekly 0.5-h counselling session, in 2002.
  
  
  RESULTS
  The mean age was 31.2 years (range 17-53). The majority [63.2%] was between 20 and 34 years of age. The educational level of most of them [55.4%] was between 6 and 12 years of study. Completion rates by groups were 83.8% for the 50-mg dose methadone group, 58.8% for the 5-mg dose buprenorphine group and 20.6% for the 50-mg dose naltrexone group (P = 0.000). Retention in the 50-mg methadone group was significantly better than in the 5-mg dose buprenorphine group (P = 0.001) and the 50-mg dose naltrexone group (P = 0.000). Retention in the 5-mg buprenorphine group was significantly better than in the 50-mg naltrexone dose group (P = 0.000).
  
  
  CONCLUSIONS
  Evaluation of the Iranian experience on this subject may be useful for other countries.
authors.affiliation: Shiraz University of Medical Sciences, Kuwait University, Iran. jamshid_ahmadi@yahoo.com
authors.forename: J
authors.initials: J
authors.lastname: Ahmadi
authors.forename: K
authors.initials: K
authors.lastname: Ahmadi
authors.forename: J
authors.initials: J
authors.lastname: Ohaeri
mesh_terms: D000284:Administration, Oral; D000286:Administration, Sublingual; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D002047:Buprenorphine / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D009271:Naltrexone / Q000008:administration & dosage* / Q000009:adverse effects; D012959:Socioeconomic Factors; D015819:Substance Abuse, Intravenous / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D002047:Buprenorphine; D009271:Naltrexone; D008691:Methadone