Prognostic value of genomic alterations in head and neck squamous cell carcinoma detected by comparative genomic hybridisation.
A total of 45 primary head and neck squamous cell carcinomas were analysed by comparative genomic hybridisation to identify regions of chromosomal deletion and gain. Multiple regions of copy number aberration were identified including gains affecting chromosomes 3q, 8q, 5p, 7q, 12p and 11q and deletion of material from chromosomes 3p, 11q, 4p, 5q, 8p, 10q, 13q and 21. Kaplan-Meier survival analysis revealed significant correlations between gain of 3q25-27 and deletion of 22q with reduced disease-specific survival. In addition, gain of 17q and 20q, deletion of 19p and 22q and amplification of 11q13 were significantly associated with reduced disease-free survival. A Cox proportional hazards regression model identified deletion of 22q as an independent prognostic marker. The data presented here provide further evidence that the creation of a genetically based tumour classification system will soon be possible, complementing current histopathological characterisation.
Ashman
J N E
JN
Academic Department of Otolaryngology Surgery, University of Hull, Hull HU6 7RX, UK.
Patmore
H S
HS
Condon
L T
LT
Cawkwell
L
L
Stafford
N D
ND
Greenman
J
J
D014408:Biomarkers, Tumor / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000401:mortality; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D004273:DNA, Neoplasm / Q000032:analysis*; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000401:mortality; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009693:Nucleic Acid Hybridization; D011379:Prognosis; D016016:Proportional Hazards Models
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm