title: Oral UFT and cyclophosphamide combination chemotherapy for metastatic breast cancer.
abstract: BACKGROUND
  Effective long-term chemotherapy yielding good quality of life is essential. The clinical benefits of oral UFT and cyclophosphamide (CPA) combination chemotherapy for metastatic breast cancer (MBC) were evaluated.
  
  
  METHODS
  Twenty cases with MBC were enrolled. The mean age was 54 years. Five cases had loco-regional and others had distant metastasis. Nineteen cases had previous therapies. Daily treatment consisted of UFT (300 to 400 mg/body) and CPA (100 to 150 mg/body), both given orally.
  
  
  RESULTS
  The treatment period ranged from 4 to 80 weeks. The response rate was 35%, while it was 65% in the "stable disease > 6 months" category. The mean time to the first sign of response was 7 weeks and the time to tumor progression was 37 weeks. The frequent adverse effects were leukocytopenia (55%) and gastrointestinal symptoms (35%). The incidence of adverse grade > or = 3 effects was 25%.
  
  
  CONCLUSIONS
  Oral UFT and CPA combination chemotherapy may be suitable for MBC.
authors.affiliation: Department of Surgery, Osaka City General Hospital, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Sung-Haw
authors.initials: SH
authors.lastname: Chung
authors.forename: Katsumi
authors.initials: K
authors.lastname: Ikeda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takashima
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Onoda
authors.forename: Bunzo
authors.initials: B
authors.lastname: Nakata
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nishiguchi
authors.forename: Kosei
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010865:Pilot Projects; D005641:Tegafur / Q000008:administration & dosage / Q000009:adverse effects; D014498:Uracil / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D005641:Tegafur; D014498:Uracil; D003520:Cyclophosphamide