title: Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment.
abstract: Leukotriene B4 (LTB4) was originally described as a potent lipid myeloid cell chemoattractant, rapidly generated from innate immune cells, that activates leukocytes through the G protein-coupled receptor BLT1. We report here that BLT1 is expressed on effector CD4+ T cells generated in vitro as well as in vivo when effector T cells migrate out of the lymphoid compartment and are recruited into peripheral tissues. BLT1 mediated LTB4-induced T helper type 1 (T(H)1) and T(H)2 cell chemotaxis and firm adhesion to endothelial cells under flow, as well as early CD4+ and CD8+ T cell recruitment into the airway in an asthma model. Our findings show that the LTB4-BLT1 pathway is involved in linking early immune system activation and early effector T cell recruitment.
authors.affiliation: Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Tager
authors.forename: Shannon K
authors.initials: SK
authors.lastname: Bromley
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Medoff
authors.forename: Sabina A
authors.initials: SA
authors.lastname: Islam
authors.forename: Scott D
authors.initials: SD
authors.lastname: Bercury
authors.forename: Erik B
authors.initials: EB
authors.lastname: Friedrich
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Carafone
authors.forename: Robert E
authors.initials: RE
authors.lastname: Gerszten
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Luster
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D005434:Flow Cytometry; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007975:Leukotriene B4 / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018102:Receptors, Leukotriene B4 / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D018102:Receptors, Leukotriene B4; D007975:Leukotriene B4; D007073:Immunoglobulin E