title: [A simple method for preparation of 18alpha-glycyrretinic acid ant its derivatives].
abstract: Treatment of 18 beta-glycyrrhizic acid with a methanolic solution of HCl resulted in a 1:1 mixture of methyl esters of 18 alpha- and 18 beta-glycyrrhetinic acids. Benzoylation of the mixture led to methyl esters of 3-benzoyl-18 alpha-glycyrrhetinic acid and 3-benzoyl-18 beta-glycyrrhetinic acid, which were separated by chromatography on silica gel. 18 alpha-Glycyrrhetinic acid was prepared by alkaline hydrolysis of methyl 3-benzoyl-18 alpha-glycyrrhetinate and was further used for the syntheses of 3-keto-18 alpha-glycyrrhetinic acid and methyl esters of 18 alpha-glycyrrhetinic acid and 3-keto-18 alpha-glycyrrhetinic acid.
authors.affiliation: Orekhovich Research Institute of Biomedicinal Chemistry, Russian Academy of Medical Sciences, Pogodinskaya ul. 10, Moscow, 119832 Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Ignatov
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Prokof'ev
authors.forename: O M
authors.initials: OM
authors.lastname: Ipatova
authors.forename: V P
authors.initials: VP
authors.lastname: Timofeev
authors.forename: N V
authors.initials: NV
authors.lastname: Medvedeva
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Misharin
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D002853:Chromatography, Liquid / Q000379:methods; D006034:Glycyrrhetinic Acid / Q000138:chemical synthesis*; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
chemical_list: D006034:Glycyrrhetinic Acid