title: Recurrent delayed brain hemorrhage over years after irradiation and chemotherapy for astrocytoma.
abstract: We report on an adult patient with a right frontal astrocytoma, classification WHO II, who suffered from radionecrosis 3.5 years after surgery and combined radio- and chemotherapy. Beginning 8 years after initial diagnosis, repeated episodes of bilateral cerebral hemorrhage and cavitation occurred. This case description emphasizes the possibility of repeated hemorrhage as a delayed reaction to brain irradiation and chemotherapy.
authors.affiliation: Department of Neuroradiology, Eberhard Karls University, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany. andreas.hillemanns@med.uni-tuebingen.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Hillemanns
authors.forename: Rolf-Dieter
authors.initials: RD
authors.lastname: Kortmann
authors.forename: Ulrich
authors.initials: U
authors.lastname: Herrlinger
authors.forename: Martin
authors.initials: M
authors.lastname: Skalej
authors.forename: Hilmar
authors.initials: H
authors.lastname: Krapf
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000188:drug therapy* / Q000532:radiotherapy*; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009336:Necrosis; D009607:Nitrosourea Compounds / Q000627:therapeutic use; D011832:Radiation Injuries / Q000150:complications; D011879:Radiotherapy Dosage; D012008:Recurrence; D013997:Time Factors
chemical_list: D009607:Nitrosourea Compounds