title: Second-generation tissue Doppler with angle-corrected color-coded wall displacement for quantitative assessment of regional left ventricular function.
abstract: To test the hypothesis that a new tissue Doppler (TD) approach using angle-correction and transformation of velocity data to color-coded displacement data may objectively quantify regional left ventricular function, in vitro experiments were first performed with an oscillating echo target precisely controlled by a microstepping motor. Displacement varied from 1 to 15 mm (60 to 130 cycles/min) at angles of 0 degrees and 45 degrees to the echo transducer. Custom software transformed TD data to displacement data. Sixty-five subjects were then studied: 35 with wall motion abnormalities and 30 normal controls. Results were compared with independent visual assessment and caliper measurements of endocardial excursion from gray-scale images. In vitro displacement imaging strongly correlated with true displacement (r = 0.99, p <0.0001). In humans, peak transmural displacement discriminated normal results (6.3 +/- 3.2 mm) from hypokinesia (2.7 +/- 1.8 mm, p <0.05), akinesia (0.4 +/- 1.2 mm, p <0.05) from hypokinesia, and dyskinesia (-1.9 +/- 1.2 mm, p <0.05) from akinesia. Normal subendocardial displacement was 5.9 +/- 2.9 versus 4.0 +/- 3.9 mm in the epicardial layer (p <0.01). This displacement gradient was absent in abnormal segments. Displacement data correlated with endocardial excursion by calipers (parasternal views: r = 0.86, all views: r = 0.79, both p <0.0001). Overall accuracy of displacement imaging was 82% (kappa = 0.71) versus 66% (kappa = 0.43) for visual assessment with caliper data as the standard of reference. Angle-corrected displacement imaging was superior to routine visual assessment and is a promising new method to quantify regional left ventricular function.
authors.affiliation: Division of Cardiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: L Elif
authors.initials: LE
authors.lastname: Sade
authors.forename: Donald A
authors.initials: DA
authors.lastname: Severyn
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kanzaki
authors.forename: Kaoru
authors.initials: K
authors.lastname: Dohi
authors.forename: John
authors.initials: J
authors.lastname: Gorcsan
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D002311:Cardiomyopathy, Dilated / Q000150:complications; D016022:Case-Control Studies; D003327:Coronary Disease / Q000150:complications; D016002:Discriminant Analysis; D018618:Echocardiography, Doppler, Color / Q000379:methods* / Q000592:standards; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods / Q000592:standards*; D016018:Least-Squares Analysis; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D016037:Single-Blind Method; D012984:Software / Q000592:standards; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology