title: Late onset of tacrolimus-related posterior leukoencephalopathy after living donor liver transplantation.
abstract: Neurotoxicity is a well-known side effect of tacrolimus-based immunosuppression after liver transplantation. Until now, only 31 cases of immunosuppression-associated leukoencephalopathy in liver transplant recipients reported in the literature are related to tacrolimus therapy. We report a patient who developed a posterior leukoencephalopathy syndrome, secondary to tacrolimus-based immunosuppression, after living donor liver transplantation. The special features of this case are the sudden and late onset of neurologic symptoms, a persistent comatose state, and increased signal intensity in follow-up MRI.
authors.affiliation: Department of General- and Transplant Surgery, University of Essen, Germany. nils.fruehauf@uni-essen.de
authors.forename: Nils R
authors.initials: NR
authors.lastname: Frühauf
authors.forename: Susanne
authors.initials: S
authors.lastname: Koeppen Dagger
authors.forename: Fuat H
authors.initials: FH
authors.lastname: Saner
authors.forename: Thomas
authors.initials: T
authors.lastname: Egelhof Dagger
authors.forename: Gregor
authors.initials: G
authors.lastname: Stavrou
authors.forename: Silvio
authors.initials: S
authors.lastname: Nadalin
authors.forename: Christoph E
authors.initials: CE
authors.lastname: Broelsch
mesh_terms: D003128:Coma / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000209:etiology* / Q000473:pathology; D016031:Liver Transplantation; D019520:Living Donors; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011183:Postoperative Complications; D016559:Tacrolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus