title: [Fasting plasma insulin and insulin sensitivity in the offspring of parents with a family hypertensive history].
abstract: OBJECTIVE
  To investigate the plasma insulin levels and insulin sensitivity in the offspring of parents with family hypertensive history in Tibetan population.
  
  
  METHODS
  Tibetan hypertensive pedigrees and normotensive pedigrees based on a door-to-door cross section study performed from 1997 to 1998 in stable communities in the ruban district of Lhasa city were set up, 47 offsprings from hypertensive pedigrees (group I) and 21 offsprings from normotensive pedigrees (group II) were enrolled into this study. Plasma insulin levels using by radioimmunoassay and insulin sensitivity with the formulae insulin sensitivity = 1/(fasting plasma glucose x fasting plasma insulin) were compared between two groups.
  
  
  RESULTS
  There were no statistically significant differences in fasting blood glucose levels between group I and group II. But fasting plasma insulin level was 10.20 +/- 6.95 m IU/L in group I and 6.56 +/- 2.81 m IU/L in group II, respectively, and there were statistically significant differences between these two groups. The insulin sensitivity index in group I was significantly lower than that in group II (0.036 +/- 0.024 and 0.046 +/- 0.022, respectively).
  
  
  CONCLUSIONS
  Offspring of Tibetan hypertensive pedigrees were observed to be hyperinsulinemia and reduced insulin sensitivity. These metabolic abnormalities may be associated with hypertension and dyslipidemia in adulthood.
authors.affiliation: Department of Cardiology, Tibet Autonomous Region People's Hospital, Institute of cardiovascular disease and high altitude sickness, Lhasa 850000, China.
authors.forename: Norpu
authors.initials: N
authors.lastname: Gelsang
authors.forename: Wei-jun
authors.initials: WJ
authors.lastname: Cen
authors.forename: Tsering
authors.initials: T
authors.lastname: Dronma
authors.forename: Tashi
authors.initials: T
authors.lastname: Pingtso
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Wen-jun
authors.initials: WJ
authors.lastname: Zhou
authors.forename: Guo-zhang
authors.initials: GZ
authors.lastname: Liu
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D002648:Child; D005215:Fasting; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics*; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D018609:Tibet
chemical_list: D001786:Blood Glucose; D007328:Insulin