Phenotypic linkage between single-nucleotide polymorphisms of beta3-adrenergic receptor gene and NADH dehydrogenase subunit-2 gene, with special reference to eating behavior.
The beta(3)-adrenergic receptor gene (BAR-3) allelic variant (Trp64Arg and Arg64Arg) is correlated with obesity or non-insulin-dependent diabetes mellitus. The mitochondrial NADH dehydrogenase subunit-2 gene (ND2) variant (Mt5178A) is associated with longevity or less susceptibility to adult-onset diseases. The frequencies of both the variants are high among the Japanese population. Cross-sectional analysis of these variants was conducted to determine if they correlated well with life-style-related phenotypes and nutrient intake. The body fat rate in the BAR-3 variant+ND2 variant group was higher than those rates in the BAR-3 normal+ND2 variant, BAR-3 normal+ND2 normal. The BAR-3 normal+ND2 variant group preferred much carbohydrate and less animal protein compared with other three groups. A combination of SNPs of the nuclear BAR-3 and the mitochondrial ND2 genes may affect eating behavior besides the biochemical and metabolic process of signal transduction and electron transfer system.
Aoyama
Misako
M
Department of Nutrition and Health Sciences, Faculty of Nursing and Nutrition, Siebold University of Nagasaki, Japan. aoyama@sun.ac.jp
Shidoji
Yoshihiro
Y
Saimei
Mari
M
Tsunawake
Noriaki
N
Ichinose
Makoto
M
D000293:Adolescent; D000328:Adult; D000483:Alleles; D050260:Carbohydrate Metabolism; D002467:Cell Nucleus / Q000378:metabolism; D004583:Electrons; D005247:Feeding Behavior; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan; D008928:Mitochondria / Q000378:metabolism; D009245:NADH Dehydrogenase / Q000737:chemistry*; D010641:Phenotype; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D015398:Signal Transduction
C098483:NADH dehydrogenase subunit 4; D022702:Receptors, Adrenergic, beta-3; D009245:NADH Dehydrogenase