SCA2 and SCA3 mutations in young-onset dopa-responsive parkinsonism.
In this study no one of our 85 patients of Serbian origin with young-onset (</= 45 years) dopa-responsive parkinsonism (YOP), previously proved negative for PARK1 and PARK2 mutations, had either spinocerebellar ataxia type 2 (SCA2) or SCA3 mutation. These data do not prove the significance of these two mutations in either sporadic or familial YOP suggestive of Parkinson's disease.
Svetel
M
M
Institute of Neurology CCS, School of Medicine, University of Belgrade, Belgrade, Serbia.
Djarmati
A
A
Dragasević
N
N
Savić
D
D
Culjković
B
B
Romac
S
S
Kostić
V S
VS
D000328:Adult; D017668:Age of Onset; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D017827:Machado-Joseph Disease / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020734:Parkinsonian Disorders / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D020754:Spinocerebellar Ataxias / Q000235:genetics*; D015022:Yugoslavia
D007980:Levodopa