title: Dietary treatment of gluten ataxia.
abstract: BACKGROUND
  Gluten ataxia is an immune mediated disease, part of the spectrum of gluten sensitivity, and accounts for up to 40% of cases of idiopathic sporadic ataxia. No systematic study of the effect of gluten-free diet on gluten ataxia has ever been undertaken.
  
  
  OBJECTIVE
  To study the effect of gluten-free diet on patients presenting with ataxia caused by gluten sensitivity.
  
  
  METHODS
  43 patients with gluten ataxia were studied. All were offered a gluten-free diet and monitored every six months. All patients underwent a battery of tests to assess their ataxia at baseline and after one year on diet. Twenty six patients (treatment group) adhered to the gluten-free diet and had evidence of elimination of antigliadin antibodies by one year. Fourteen patients refused the diet (control group). Three patients had persistently raised antigliadin antibodies despite adherence to the diet and were therefore excluded from the analysis.
  
  
  RESULTS
  After one year there was improvement in ataxia reflected in all of the ataxia tests in the treatment group. This was significant when compared with the control group. The diet associated improvement was apparent irrespective of the presence of an enteropathy.
  
  
  CONCLUSIONS
  Gluten ataxia responds to a strict gluten-free diet even in the absence of an enteropathy. The diagnosis of gluten ataxia is vital as it is one of the very few treatable causes of sporadic ataxia.
authors.affiliation: Department of Clinical Neurology, The Royal Hallamshire Hospital, Sheffield, UK. m.hadjivassiliou@sheffield.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Hadjivassiliou
authors.forename: G A B
authors.initials: GA
authors.lastname: Davies-Jones
authors.forename: D S
authors.initials: DS
authors.lastname: Sanders
authors.forename: R A
authors.initials: RA
authors.lastname: Grünewald
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000917:Antibody Formation; D001259:Ataxia / Q000178:diet therapy* / Q000209:etiology*; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications* / Q000178:diet therapy*; D005983:Glutens / Q000276:immunology* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D016896:Treatment Outcome
chemical_list: D005983:Glutens