Modification of chemotherapeutic activity in adriablastine with the synthetic antioxidant in low doses.
Synthetic antioxidant potassium phenosan in ultralow doses administrated in combination with antitumor antibiotic adriamycin in a therapeutic dose (8 mg/kg) markedly prolonged the mean life span of tumor-bearing animals compared to adriamycin monotherapy. This effect depended on the dose of antioxidant and was maximum at phenosan concentrations of 10(-17) and 10(-15) M. Potassium phenosan in these concentrations not only increased the mean life span, but also determined survival of 10-20% animals (as differentiated from adriamycin monotherapy).
Pal'mina
N P
NP
N. M. Emanuel' Institute of Biochemical Physics, Russian Academy of Sciences, Moscow.
Gaintseva
V D
VD
Burlakova
Ye B
YB
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D004317:Doxorubicin / Q000627:therapeutic use; D004347:Drug Interactions; D007938:Leukemia / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D010640:Phenothiazines / Q000627:therapeutic use
D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D010640:Phenothiazines; D004317:Doxorubicin; C031637:phenothiazine