Zinc regulation of food intake: new insights on the role of neuropeptide Y.
The role of neuropeptide Y (NPY) in feeding behavior and zinc deficiency-induced anorexia has been controversial because hypothalamic NPY levels are elevated in both zinc deficiency and food restriction. A recent report shows that while NPY is released from terminals in the paraventricular nucleus of the hypothalamus of food-restricted animals, this release is significantly impaired in zinc-deficient animals. Zinc deficiency may therefore cause anorexia by inhibiting the release of NPY that is required for receptor activation.
Levenson
Cathy W
CW
Florida State University, Program in Neuroscience, Department of Nutrition, Food & Exercise Sciences, 237 Biomedical Research Facility, Tallahassee, FL 32306-4340, USA.
D000293:Adolescent; D000328:Adult; D000818:Animals; D000856:Anorexia Nervosa / Q000188:drug therapy / Q000378:metabolism*; D004435:Eating / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D015032:Zinc / Q000172:deficiency* / Q000378:metabolism / Q000494:pharmacology
D009478:Neuropeptide Y; D015032:Zinc