Labeling of organic biomolecules with ethynylferrocene.
The Sonogashira coupling reaction of ethynylferrocene with adenine, uracil, tyrosine and steroid derivatives was studied; with the exception of tyrosine it was proved to be a good route for the attachment of ferrocene to these representative biomolecules. In addition the transformation of alkynyl uracil to furanopyrimidone derivatives was investigated and the formation of the furanopyrimidone ring was confirmed by an X-ray crystallographic analysis carried out on product 16.
Coutouli-Argyropoulou
Evdoxia
E
Department of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece. evd@chem.auth.gr
Tsitabani
Maria
M
Petrantonakis
Georgios
G
Terzis
Aris
A
Raptopoulou
Catherine
C
D018360:Crystallography, X-Ray; D005296:Ferrous Compounds / Q000737:chemistry*; D008958:Models, Molecular; D009930:Organic Chemicals / Q000737:chemistry*
D005296:Ferrous Compounds; D009930:Organic Chemicals; C480779:ethynylferrocene