[The diagnostic value of determining the level of acetaldehyde in blood, urine, and cerebrospinal fluid].
The contents of acetaldehyde (AA) in biological fluids obtained from the dead with the confirmed lethality causes, i.e. ischemic heart disease (IHD), alcoholic cardiomyopathy (ACMP) and mechanical traumas (MT), were examined on an actual forensic-medical material (AFMM). 14 death cases of males, aged 18 to 45, were studied. The method of gas-liquid chromatography (GLC), or rather its variation of vaporphase analysis, was used to state the presence and to assess the concentration of acetaldehyde. The results revealed differences between concentrations of acetaldehyde in the examined groups depending on the presence or absence of alcoholemia. Thus, the AA concentrations were found in trace quantities in the MT group free of alcoholic intoxication; while, when it was present in this group, the concentrations went up several-fold. A higher AA content was typical of the ACMP group in all examined subjects both with and without alcoholic intoxication. The final study results are suggestive of that the AA determination in blood, urine and liquor by GLC could be used, within the forensic medical practice, in assessing a severity degree of alcoholic intoxication while establishing the lethal outcome cause due to chronic pathologies and MT.
Morozov
Iu E
IuE
Vasil'eva
E V
EV
Mammadov
V K
VK
Salomatin
E M
EM
D000079:Acetaldehyde / Q000097:blood / Q000134:cerebrospinal fluid / Q000652:urine; D000293:Adolescent; D000328:Adult; D000435:Alcoholic Intoxication / Q000175:diagnosis*; D001344:Autopsy; D002849:Chromatography, Gas; D005554:Forensic Medicine / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged
D000079:Acetaldehyde