title: Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain.
abstract: Caldendrin defines a novel family of neuronal calcium-sensor proteins, the C-terminal moiety of which displays high similarity to calmodulin. We now report that the protein is recruited to the postsynaptic density (PSD) of cortical and hippocampal neurons in response to kainate-induced epileptic seizures, an animal model of human temporal lobe epilepsy. The translocation of caldendrin to the PSD did not occur in kainate-treated rats that did not develop seizures. The enhanced PSD levels of caldendrin are not due to increased protein synthesis and most likely reflect a recruitment from the soluble caldendrin protein pool. These findings suggest that the transduction of dendritic Ca2+-signals via caldendrin is altered by epileptic seizures and that caldendrin might be involved in the pathophysiology of temporal lobe epilepsy.
authors.affiliation: AG Molecular Mechanisms of Plasticity, Department of Neurochemistry/Molecular Biology, Leibniz-Institute for Neurobiology, Brenneckestrasse 6, Magdeburg 39118, Germany.
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Smalla
authors.forename: Constanze I
authors.initials: CI
authors.lastname: Seidenbecher
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Tischmeyer
authors.forename: Horst
authors.initials: H
authors.lastname: Schicknick
authors.forename: Ursula
authors.initials: U
authors.lastname: Wyneken
authors.forename: Tobias M
authors.initials: TM
authors.lastname: Böckers
authors.forename: Eckart D
authors.initials: ED
authors.lastname: Gundelfinger
authors.forename: Michael R
authors.initials: MR
authors.lastname: Kreutz
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D003720:Densitometry; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D018690:Excitatory Amino Acid Agonists; D015151:Immunoblotting; D007608:Kainic Acid; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism
chemical_list: D002135:Calcium-Binding Proteins; D018690:Excitatory Amino Acid Agonists; D009419:Nerve Tissue Proteins; D020033:Protein Isoforms; C085577:Ca2+-binding protein-1; D007608:Kainic Acid