Immunoglobulin G profiles in different forms of periodontitis.
BACKGROUND
Races and Gm(23) allotypes can modify the serum levels of IgG subclasses. The average serum levels of IgG subclasses of African-Americans have been reported to be higher than those of Caucasians in both healthy young adults and patients with aggressive periodontitis; Gm(23)-positive subjects generally had higher IgG2 levels than Gm(23)-negative subjects.


OBJECTIVE
We examined serum immunoglobulin G (IgG) concentrations in Taiwanese patients with different forms of periodontitis.


METHODS
The serum levels of four IgG subclasses were determined by enzyme-linked immunosorbent assay and Gm(23) allotypes were verified by radial immunodiffusion tests in 50 patients with chronic periodontitis, 30 patients with aggressive periodontitis, and 74 healthy controls.


RESULTS
There were no differences in the concentrations of four IgG subclasses in patients with chronic periodontitis compared with age-matched controls. However, in subjects younger than 35 years, levels of IgG2 were significantly elevated in patients with aggressive periodontitis compared with controls. We also found significant differences in IgG2 levels within the control group when stratified by age (< or = 35 years and > 35 years). Gm(23) allotypes were not correlated with the serum levels of IgG2 in either patient group.


CONCLUSIONS
Microbial challenge might not provoke significant changes in systemic IgG response in patients with chronic periodontitis. However, in patients with aggressive periodontitis, IgG2 levels were increased when compared with age-matched controls. Gm(23) allotypes had no influence on IgG2 levels in well-established generalized chronic periodontitis or aggressive periodontitis.
Chung
Hsien-Yang
HY
Department of Dentistry, China Medical College Hospital, Taiwan.
Lu
Hsi-Chi
HC
Chen
Woan-Ling
WL
Lu
Chun-Tai
CT
Yang
Yi-Hsin
YH
Tsai
Chi-Cheng
CC
D000328:Adult; D000367:Age Factors; D010520:Aggressive Periodontitis / Q000097:blood / Q000276:immunology; D044466:Asian People; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007129:Immunoglobulin Gm Allotypes; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000097:blood / Q000276:immunology*; D013624:Taiwan
D007074:Immunoglobulin G; D007129:Immunoglobulin Gm Allotypes