title: Effect of dietary intake and protease inhibitors on serum vitamin B12 levels in a cohort of human immunodeficiency virus-positive patients.
abstract: The dietary intake of micronutrients and serum micronutrient status have been topics of concern in relation to human immunodeficiency virus (HIV) progression. Most data, however, were collected prior to the introduction of protease inhibitors (PIs). We analyzed dietary intake and serum values of vitamin B(12), including the effect of PIs, in a cohort of persons with HIV infection. During intervals with no PI use, each 1 microg/day increase in B(12) intake was associated with a 1.06 pg/mL increase in serum B(12) levels. However, during intervals with PI use, each 1 microg/day increase in intake was associated with only a 0.12 increase in serum B(12) levels. Adequate serum B(12) levels (>350 pg/mL) cannot be assumed even in the presence of PIs, and dietary supplementation may not be adequate to significantly increase serum B(12) levels. Serum B(12) levels should be determined yearly in persons with HIV infection, regardless of whether they are receiving PI treatment.
authors.affiliation: Division of Nutrition and Infection, Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, MA 02111, USA. margo.woods@tufts.edu
authors.forename: Margo N
authors.initials: MN
authors.lastname: Woods
authors.forename: Alice M
authors.initials: AM
authors.lastname: Tang
authors.forename: Janet
authors.initials: J
authors.lastname: Forrester
authors.forename: Clara
authors.initials: C
authors.lastname: Jones
authors.forename: Kristy
authors.initials: K
authors.lastname: Hendricks
authors.forename: Bei
authors.initials: B
authors.lastname: Ding
authors.forename: Tamsin A
authors.initials: TA
authors.lastname: Knox
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D006801:Humans; D008297:Male; D015596:Nutrition Assessment; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000097:blood*
chemical_list: D017320:HIV Protease Inhibitors; D014805:Vitamin B 12