Antifungal flavanones and prenylated hydroquinones from Piper crassinervium Kunth.
Bioactivity-guided fractionation of the EtOAc extract from leaves of Piper crassinervium yielded three prenylated hydroquinones together with two known flavanones naringenin and sakuranetin. Their structures were determined by means of spectroscopic analysis (NMR, IR, UV and MS) including two-dimensional NMR spectroscopy experiments (1H-1H COSY, HMQC, HMBC and NOESY). The antifungal activity was determined by direct bioautography against Cladosporium cladosporioides and C. sphaerospermum.
Danelutte
Ana Paula
AP
Instituto de Química, Universidade de São Paulo, C.P. 26077, CEP 05599-970, São Paulo, SP, Brazil.
Lago
João Henrique G
JH
Young
Maria Claudia M
MC
Kato
Massuo J
MJ
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002963:Cladosporium / Q000187:drug effects; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006873:Hydroquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D026321:Piperaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D000094162:Phytoalexins
D000935:Antifungal Agents; D044950:Flavanones; D005419:Flavonoids; D006873:Hydroquinones; D010936:Plant Extracts; C099724:sakuranetin; D000094162:Phytoalexins; C005273:naringenin