title: [Clinical and laboratory studies on childhood acute leukemia with 11q23 abnormalities].
abstract: OBJECTIVE
  To investigate the interrelations among morphology, immunology, cytogenetics and clinical outcome in childhood acute leukemia with 11q23 abnormalities.
  
  
  METHODS
  Eighteen patients with 11q23 abnormalities, from 320 childhood acute leukemia patients, were retrospectively analysed for cell morphology, flow cytometry, immunophenotyping, R-banding karyotype as well as clinical features and prognosis. Twenty cases of childhood AL with normal karyotype during the same period were used as control.
  
  
  RESULTS
  The incidence of 11q23 abnormalities in our childhood acute leukemia patients was 5.63% including 14 acute lymphoblastic leukemia (ALL) and 4 acute myeloid leukemia (AML). Of 16 cases immunophenotypically tested, 13 expressed lymphoid antigens and 3 CD(34) and other myeloid antigens. Karyotype analysis disclosed the following abnormalities: t(4; 11)(q21; q23) in 6 cases, t(10; 11)(p13; q23) in 3, t(11; 19)(q23; p13) in one and del(11)(q23) in 6. The complete remission rate for these patients with 11q23 abnormalities was comparable to that of the control (72.2% vs 80.0%, P > 0.05), while the mortality rate in the former was significantly higher than that in the latter (61.1% vs 25.0%, P < 0.05).
  
  
  CONCLUSIONS
  11q23 abnormalities were mainly seen in childhood ALL and acute monocytic leukemia with unique prognostic features.
authors.affiliation: Children's Hospital of Suzhou University, Suzhou 215003, China.
authors.forename: Ya-xiang
authors.initials: YX
authors.lastname: He
authors.forename: Yong-quan
authors.initials: YQ
authors.lastname: Xue
authors.forename: Jun
authors.initials: J
authors.lastname: He
authors.forename: Xue-lan
authors.initials: XL
authors.lastname: Zhang
authors.forename: Zheng-hua
authors.initials: ZH
authors.lastname: Ji
authors.forename: Yi-ping
authors.initials: YP
authors.lastname: Huang
authors.forename: Xue-ming
authors.initials: XM
authors.lastname: Zhu
authors.forename: Hai-long
authors.initials: HL
authors.lastname: He
authors.forename: Yi-huan
authors.initials: YH
authors.lastname: Chai
authors.forename: Ling-li
authors.initials: LL
authors.lastname: Zhu
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007223:Infant; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies