title: Restoration of red blood cell volume following 2-unit red blood cell apheresis.
abstract: OBJECTIVE
  Blood donors who weigh at least 130 lbs (59 kg) and have a haematocrit of at least 40 V per cent can donate 2 units of blood, from which a 360-ml volume of red blood cells (RBC) can be isolated. This study was carried out in seven healthy male blood donors to assess the restoration of the RBC volume 1 month following a 2-unit RBC apheresis procedure.
  
  
  METHODS
  RBC volumes were measured prior to donation and 4 weeks after the 2-unit RBC apheresis procedure without oral iron supplementation.
  
  
  RESULTS
  Four weeks after the removal of 2 units of RBC from the male donors not supplemented with oral iron, the RBC volume was restored to 92% of the precollection value. The 360-ml volume of RBC collected represented 12-19% of the donor's original RBC volume.
  
  
  CONCLUSIONS
  Male donors can safely donate 2 units of RBC and will restore a mean of 92% of their RBC volume within 1 month without iron supplementation.
authors.affiliation: Naval Blood Research Laboratory, Boston University School of Medicine, Boston, MA 02118, USA. navblood@bu.edu
authors.forename: C R
authors.initials: CR
authors.lastname: Valeri
authors.forename: G
authors.initials: G
authors.lastname: Ragno
authors.forename: R
authors.initials: R
authors.lastname: Srey
mesh_terms: D000328:Adult; D001781:Blood Component Removal; D001782:Blood Donors; D017707:Erythrocyte Transfusion; D004911:Erythrocyte Volume; D006400:Hematocrit; D006801:Humans; D008297:Male; D013997:Time Factors