[Application of intravenous immunoglobulin therapy (IVIG) in pregnant patients with recurrent spontaneous abortions].
OBJECTIVE
Clinical outcome of pregnancy in patients with recurrent pregnancy losses treated with IVIG during their current pregnancy.


METHODS
The study group consisted of 10 pregnant women with 3-5 spontaneous abortions. Any genetic, anatomical or infectious abnormalities were excluded as well as antiphospholipid antibody syndrome and negative lymphocytotoxic test. The treatment consisted of passive immunotherapy by means of intravenous administration of immunoglobulin (IVIG) at a dose of 0.4 g/kg b.w. Therapy was commenced at week 5-6 of gestation, infusions were repeated every 3-4 weeks until 28th week of gestation in 5-, 3- and 1-day protocols. In 2 patients that therapy followed active immunotherapy with paternal lymphocytes.


RESULTS
Eight (80%) patients bore healthy babies (3 preterm); in 2 cases embryos died at 6-7 week of gestation.


CONCLUSIONS
The results confirm the efficacy of IVIG in pregnant patients with recurrent spontaneous abortions in whom likelihood of immunological pattern of pregnancy failures is high.
Sipak-Szmigiel
Olimpia
O
Kliniki Patologii Ciazy i Porodu Pomorskiej Akademii Medycznej, Szczecinie.
Ronin-Walknowska
Elzbieta
E
Mikłaszwicz
Andrzej
A
D000026:Abortion, Habitual / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control*; D000328:Adult; D005260:Female; D005313:Fetal Death / Q000517:prevention & control*; D006801:Humans; D007116:Immunization, Passive / Q000379:methods; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D011247:Pregnancy; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome
D016756:Immunoglobulins, Intravenous