title: [Concomitant chemoradiotherapy in the treatment of carcinoma of the uterine cervix].
abstract: Cervical carcinoma represents a serious medical and social problem. Its incidence in the Czech republic is two times higher than it is in countries of the European Union. Initial stages of the disease have the best treatment results. But most of patients at the time of diagnosis have advanced inoperable carcinoma. Radiotherapy plays the main role in the treatment. Even though methods of radiotherapy have developed, treatment results have not been satisfying enough. The aim of chemotherapy is to improve these results. The effectiveness of adjuvant, neoadjuvant and concomitant chemotherapy was studied by number of authors. Concomitant chemoradiotherapy is considered as the most effective treatment. Concomitant weekly application of cis-platinum in the dose of 40-50 mg/m2 is a widely used standard regimen. Radiopotential effect of other cytostatic drugs has been studied in several ongoing trials.
authors.affiliation: Klinika komplexní onkologické péce-oddĕlení radiacní onkologie, Masarykův onkologický ústav, Brno. kalabova@mou.cz
authors.forename: R
authors.initials: R
authors.lastname: Kalábová
authors.forename: R
authors.initials: R
authors.lastname: Soumarová
authors.forename: Z
authors.initials: Z
authors.lastname: Seneklová
mesh_terms: D002277:Carcinoma / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*