title: [Dendritic cells and their role in inflammation in the central nervous system].
abstract: Dendritic cells play a key role in initiation and regulation of adaptive immunity against pathogens and tumors, as well as in autoimmune disease. In this article we review recent data regarding distribution of dendritic cells in the central nervous system, their role in responses and possible role in pathogenesis of multiple sclerosis. We also consider possibilities to use dendritic cells as immunotherapeutic targets in multiple sclerosis.
authors.forename: M V
authors.initials: MV
authors.lastname: Pashchenkov
authors.forename: B V
authors.initials: BV
authors.lastname: Pinegin
authors.forename: Kh
authors.initials: Kh
authors.lastname: Link
authors.forename: A N
authors.initials: AN
authors.lastname: Boĭko
mesh_terms: D001692:Biological Transport / Q000502:physiology; D015704:CD4 Antigens / Q000276:immunology; D002465:Cell Movement / Q000502:physiology; D002490:Central Nervous System / Q000276:immunology* / Q000473:pathology*; D016207:Cytokines / Q000276:immunology; D003712:Dendrites / Q000276:immunology / Q000473:pathology / Q000502:physiology*; D006684:HLA-DR Antigens / Q000276:immunology; D059810:HLA-DR Serological Subtypes; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology* / Q000473:pathology*; D013601:T-Lymphocytes / Q000502:physiology
chemical_list: D015704:CD4 Antigens; D016207:Cytokines; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C106559:HLA-DR15 antigen