Intramural plasminogen activator inhibitor type-1 and coronary atherosclerosis.
Altered expression of plasminogen activator inhibitor type-1 in vessel walls, reviewed here, might affect coronary atherogenesis. Upregulation might exacerbate vasculopathy by potentiating thrombosis and by inhibiting vascular smooth muscle cell migration, resulting in attenuation of thickness of elaborated fibrous caps implicated in the vulnerability of atheroma to rupture.
Sobel
Burton E
BE
Department of Medicine, University of Vermont, Burlington, USA. Burt.sobel@vtmednet.org
Taatjes
Douglas J
DJ
Schneider
David J
DJ
D000818:Animals; D003324:Coronary Artery Disease / Q000378:metabolism*; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology; D007333:Insulin Resistance / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*; D017539:Tunica Intima / Q000378:metabolism
D007328:Insulin; D017395:Plasminogen Activator Inhibitor 1