title: Levels of metal ions after small- and large-diameter metal-on-metal hip arthroplasty.
abstract: Metal-on-metal (MOM) bearings for hip arthroplasty are increasing in popularity. Concern remains, however, regarding the potential toxicological effects of the metal ions which these bearings release. The serum levels of cobalt and chromium in 22 patients who had undergone MOM resurfacing arthroplasty were compared with a matched group of 22 patients who had undergone 28 mm MOM total hip arthroplasty (THA). At a median of 16 months (7 to 56) after resurfacing arthroplasty, we found the median serum levels of cobalt and chromium to be 38 nmol/l (14 to 44) and 53 nmol/l (23 to 165) respectively. These were significantly greater than the levels after 28 mm MOM THA which were 22 nmol/l (15 to 87, p = 0.021) and 19 nmol/l (2 to 58, p < 0.001) respectively. Since the upper limit for normal patients without implants is typically 5 nmol/l, both groups had significantly raised levels of metal ions. MOM bearings of large diameter, however, result in a greater systemic exposure of cobalt and chromium ions than bearings of small diameter. This may be of relevance for potential long-term side-effects. It is not known to what extent this difference is due to corrosion of the surfaces of the component or of the wear particles produced.
authors.affiliation: Orthopaedic Surgery, SUNY-Upstate Medical University, Syracuse, New York 13202, USA.
authors.forename: M T
authors.initials: MT
authors.lastname: Clarke
authors.forename: P T H
authors.initials: PT
authors.lastname: Lee
authors.forename: A
authors.initials: A
authors.lastname: Arora
authors.forename: R N
authors.initials: RN
authors.lastname: Villar
mesh_terms: D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000379:methods; D016022:Case-Control Studies; D002857:Chromium / Q000097:blood*; D003035:Cobalt / Q000097:blood*; D006622:Hip Prosthesis; D006801:Humans; D008670:Metals / Q000009:adverse effects*; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values
chemical_list: D008670:Metals; D002857:Chromium; D003035:Cobalt