Effects of potentiated antibodies against brain-specific S100 protein on biogenic amine content and lipid peroxidation in rats under conditions of alcoholization.
Antibodies against S100 protein in ultralow doses specifically affected catecholamine metabolism in rats withdrawn from chronic ethanol exposure. The contents of tryptophan, tyrosine, and norepinephrine in brain structures returned to normal. The concentrations of dopamine, epinephrine, and norepinephrine in the peripheral blood decreased. Modulation of monoamine content in the peripheral blood suggests that antibodies against S100 protein possess stress-protective activity during ethanol withdrawal.
Titkova
A M
AM
Institute of Neurology, Psychiatry, and Narcology, Ukrainian Academy of Medical Sciences, Kharkov.
Pan
I R
IR
Epstein
O I
OI
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D000431:Ethanol / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism; D051381:Rats; D009418:S100 Proteins / Q000276:immunology*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy; D014364:Tryptophan / Q000097:blood; D014443:Tyrosine / Q000097:blood
D000906:Antibodies; D001679:Biogenic Amines; D009418:S100 Proteins; D000431:Ethanol; D014443:Tyrosine; D014364:Tryptophan; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine