[Early diagnosis of Kawasaki disease complicated by coronary artery lesions].
OBJECTIVE
To explore the possibility of early diagnosis of Kawasaki disease (KD) complicated by coronary artery lesions (CAL).


METHODS
Medical records of 84 children with KD (2 months to 8 years of age) were reviewed retrospectively. Diagnosis of KD was based on current diagnostic criteria of KD. Laboratory examinations were performed for white blood cells (WBC), hemoglobin (HB), platelet counts (Plt), and C-reactive protein (CRP), along with electrocardiography (ECG) and echocardiography within 7 days after the onset of the disease. The Pearson correlation and multivariate analysis (logistic) were used for statistical analysis.


RESULTS
During the first 7 days, clinical manifestations of the patients included fever (100%), conjunctivitis (71.46%), skin rash (66.7%), extremity change (54%), oral mucosa change (80%), and cervical lymphadenopathy (25%). Laboratory examinations revealed elevated WBC, CRP, and ECG (P<0.05, 0.05,0.01, respectively) in patients with CAL. Multivariate logistic regression analysis indicated that ECG positivity (P<0.01) and WBC increases (P<0.01) were independently correlated with CALs in acute KD.


CONCLUSIONS
CRP (+), ECG (+), WBC count increase during the acute phase of KD are important indicators to predict CAL caused by KD.
Hu
Xiao-hong
XH
Department of Pediatrics, General Hospital of the Navy, Beijing 100037, China.
Xu
Shi-xia
SX
Luan
Zuo
Z
D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003327:Coronary Disease / Q000175:diagnosis*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D016015:Logistic Models; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D010976:Platelet Count; D012189:Retrospective Studies
D006454:Hemoglobins; D002097:C-Reactive Protein