Axonal recovery after severe traumatic brain injury demonstrated in vivo by 1H MR spectroscopy.
Proton magnetic resonance spectroscopy (MRS) suggested almost complete axonal recovery 21 months after trauma in a patient with severe diffuse axonal injury. MRS while the patient was comatose showed evidence of severe diffuse axonal injury in occipitoparietal white matter, but occipital grey matter was relatively spared. At 21 months N-acetylaspartate was normal. At 33 months examination showed a Functional Independence Measure of 83 and a Rancho Los Amigos Scale of Cognitive Function of 7-8, a remarkable improvement considering all the initial findings, except those of MRS.
Danielsen
E R
ER
Department of Neuroradiology, Section 3023, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. erdanielsen@rh.dk
Christensen
P B
PB
Arlien-Søborg
P
P
Thomsen
C
C
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001369:Axons / Q000473:pathology*; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001930:Brain Injuries / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology; D003071:Cognition; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011522:Protons; D020127:Recovery of Function; D015599:Trauma Severity Indices
D011522:Protons; D001224:Aspartic Acid; C000179:N-acetylaspartate