title: Apolipoprotein E genotype in patients with Alzheimer's disease.
abstract: OBJECTIVE
  To explore the frequency and significance of ApoE gene polymorphisms in patients with sporadic Alzheimer's disease (AD).
  
  
  METHODS
  Single nucleotide polymorphisms of the ApoE gene were analyzed in 32 cases of AD and 26 controls, using PCR and gene sequencing.
  
  
  RESULTS
  The single nucleotide polymorphism of ApoE gene 462C/G was significantly associated with AD (P < 0.05).
  
  
  CONCLUSIONS
  The 462C/G polymorphism might be a specific genotype in Chinese patients with sporadic AD.
authors.affiliation: Department of Neurology, First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310003, China. lobenyan@263.net
authors.forename: Benyan
authors.initials: B
authors.lastname: Luo
authors.forename: Zhi
authors.initials: Z
authors.lastname: Chen
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Pan
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D001057:Apolipoproteins E