Designing proteins for therapeutic applications.
Protein design is becoming an increasingly useful tool for optimizing protein drugs and creating novel biotherapeutics. Recent progress includes the engineering of monoclonal antibodies, cytokines, enzymes and viral fusion inhibitors.
Lazar
Greg A
GA
Xencor, 111 West Lemon Avenue, Monrovia, CA 91016, USA.
Marshall
Shannon A
SA
Plecs
Joseph J
JJ
Mayo
Stephen L
SL
Desjarlais
John R
JR
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D016207:Cytokines / Q000494:pharmacology; D006801:Humans; D015202:Protein Engineering; D011506:Proteins / Q000494:pharmacology*
D000911:Antibodies, Monoclonal; D000998:Antiviral Agents; D016207:Cytokines; D011506:Proteins