Synthesis characterization and anticancer activity studies on some Mannich bases derived from 1,2,4-triazoles.
A series of 3-substituted 4-[5-(4-methoxy-2-nitrophenyl)-2-furfurylidene] amino-5-mercapto-1,2,4-triazoles (3) were synthesized. Aminomethylation of compounds 3 with formaldehyde and various secondary amines furnished Mannich bases 4 and 5. These compounds were characterized on the basis of IR, 1H-NMR, mass spectral data and elemental analysis. The newly synthesized compounds were screened for their anticancer activity against a panel of 60 cell lines derived from seven cancer types namely, lung, colon, melanoma, renal, ovarian, CNS and leukemia. Some of the compounds were slightly more potent.
Shivarama Holla
B
B
Department of P.G. Studies and Research in Chemistry, Mangalore University, Mangalagangotri, 574199, India. bhadrasettyv@yahoo.com
Veerendra
B
B
Shivananda
M K
MK
Poojary
Boja
B
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008352:Mannich Bases / Q000138:chemical synthesis / Q000494:pharmacology*; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared; D014230:Triazoles / Q000737:chemistry*
D000970:Antineoplastic Agents; D005663:Furans; D008352:Mannich Bases; D014230:Triazoles