Studies on the large scale synthesis and anti-tumor activity of YSL.
H-Tyr-Ser-Leu-OH (YSL), isolated from the degradation products of porcine spleen, was synthesized by a solution method on a large scale via two synthetic strategies. Its structure was confirmed by spectroscopic and related analyses. The in vivo anti-tumor activity was evaluated with murine H22 tumor models. The result indicated that, with the administration of YSL, the survival time of the murine H22 implanted mice was significantly prolonged.
Wang
Chao
C
College of Pharmaceutical Sciences, Peking University, Beijing, P.R. China.
Ding
Wenfeng
W
Zhao
Ming
M
Lin
Gang
G
Peng
Shiqi
S
D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008969:Molecular Sequence Data; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D015996:Survival Rate
D000970:Antineoplastic Agents; D009842:Oligopeptides; C484773:H-Tyr-Ser-Leu-OH