[Study on the inclusion interaction of beta-cyclodextrin with phosphatidylcholine by UV spectra].
A kind of cyclic oligosaccharides, beta-cyclodextrin (beta-CD) was found to possess inclusion ability with phosphatidylcholine (PC). The inclusion compound of beta-CD with PC was studied by elemental analysis of solid inclusion compound and UV spectra of different mole ratios beta-CD/PC in H2O-MeOH solution. The results indicate that two moles of beta-CD include one mole PC to form inclusion compound by Van Der Waals force, hydrophobic interaction and hydrogen bounds, etc. The selective binding ability of beta-CD with PC has been discussed from the viewpoint of size/shape-fitting and geometry fitting between the host cavity and the gust molecular. The solubility in aqueous solution, the oxidation stability of PC was increased by inclusion with beta-CD.
Xie
W
W
Department of Chemistry and Chemical Engineering, Zhengzhou Institute of Technology, Zhengzhou 450052, China.
Xu
W
W
Feng
G
G
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003505:Cyclodextrins / Q000737:chemistry*; D004347:Drug Interactions; D006860:Hydrogen Bonding; D010713:Phosphatidylcholines / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D003505:Cyclodextrins; D010713:Phosphatidylcholines