A simplified and comprehensive computational model to study the behavior of T cell populations in the thymus during normal maturation and in infection with mouse moloney leukemiavirus.
Based on a previously developed theory of dysregulative lymphoma pathogenesis, an advanced mathematical model was developed for simulation of thymic T cell populations and their differentiation stages. The model subsequently was tested in comparison to thymic changes in mice with Moloneyvirus infection and leukemia development. Numerical examples are given, which suggest that the model is useful to study T cell proliferation, differentiation, and may probably also be useful to simulate T cell changes in various lymphoproliferative diseases.
Wang
Guanyu
G
Department of Pathology, University of Texas Houston Medical School, School of Health Information Sciences, University of Texas Health Science Center, Houston, 77030, USA. Guanyu.Wang@uth.tmc.edu
Krueger
Gerhard R F
GR
Buja
L Maximilian
LM
D000818:Animals; D004195:Disease Models, Animal; D007700:Kinetics; D007942:Leukemia, Experimental / Q000276:immunology* / Q000821:virology; D008213:Lymphocyte Activation; D051379:Mice; D008979:Moloney murine leukemia virus / Q000472:pathogenicity*; D012016:Reference Values; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000254:growth & development / Q000276:immunology*; D013997:Time Factors