title: The pathogenesis of Schmorl's nodes.
abstract: We examined the pathogenesis of Schmorl's nodes, correlating the histological findings from 12 lumbar vertebrae with the corresponding conventional radiographs, tomographs, MR images and CT scans. The last revealed round, often multiple cystic lesions with indistinct sclerotic margins beneath the cartilaginous endplate. The appearances are similar to the typical CT changes of osteonecrosis. Histological examination of en-bloc slices through Schmorl's nodes gave clear evidence of subchondral osteonecrosis. Beneath the cartilage endplate, we found fibrosis within the marrow cavities with the disappearance of fat cells. Osteocytes within bone trabeculae were either dead or had disappeared. We suggest that Schmorl's nodes are the end result of ischaemic necrosis beneath the cartilaginous endplate and that herniation into the body of the vertebra is secondary.
authors.affiliation: Department of Orthopaedics, 304th Hospital, Beijing, China.
authors.forename: B
authors.initials: B
authors.lastname: Peng
authors.forename: W
authors.initials: W
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Hou
authors.forename: W
authors.initials: W
authors.lastname: Shang
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D001416:Back Pain / Q000209:etiology; D001845:Bone Cysts / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D011859:Radiography; D013122:Spinal Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*