[Efficacy of losartan treatment of right ventricular cardiac insufficiency in patients with chronic obstructive bronchitis].
We examined 44 patients with chronic obstructive bronchitis (COB) and clinical symptoms of right ventricular failure (RVF). Hemodynamic parameters were registered at echocardiography in M- and B-doppler modes. Gas composition of the blood was studied with Astrrope micromethod. Rheological properties of venous blood were studied on rotation viscosimeter AKP-2. Losartan addition to combined therapy of COB and RVI improves clinical status of the patients and corrects the indices of central, pulmonary and peripheral hemodynamics, the number of patients with ischemic episodes diminished by 60%. The drug does not deteriorate the external respiration function, electrolytic balance, gas composition and blood rheology. Thus, losartan is effective in combined therapy of RVF in COB patients.
Butorov
I V
IV
Verbitskiĭ
O N
ON
Butorov
S I
SI
Paraska
V I
VI
D000328:Adult; D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D029481:Bronchitis, Chronic / Q000150:complications; D004359:Drug Therapy, Combination; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D019808:Losartan / Q000627:therapeutic use*; D008173:Lung Diseases, Obstructive / Q000150:complications; D008875:Middle Aged; D016896:Treatment Outcome; D018497:Ventricular Dysfunction, Right / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology
D000804:Angiotensin II; D019808:Losartan