title: Hypophosphatemic rickets and osteomalacia in polyostotic fibrous dysplasia.
abstract: A 17 year-old girl with polyostotic fibrous dysplasia and hypophosphatemia had inappropriately low tubular reabsorption of phosphate. She had radiological evidence of rickets and osteomalacia. The patient showed clinical improvement after treatment with phosphate supplementation, active vitamin D (calcitriol) and alendronate. It is postulated that either a phosphaturic substance elaborated from the dysplastic bone or target-organ (kidney) unresponsiveness may interfere with phosphate reabsorption in the renal tubule.
authors.affiliation: Department of Endocrinology, PGIMER, Chandigarh, India.
authors.forename: Arijit
authors.initials: A
authors.lastname: Chattopadhyay
authors.forename: Anil
authors.initials: A
authors.lastname: Bhansali
authors.forename: Sambit K
authors.initials: SK
authors.lastname: Mohanty
authors.forename: N
authors.initials: N
authors.lastname: Khandelwal
authors.forename: S K
authors.initials: SK
authors.lastname: Mathur
authors.forename: R J
authors.initials: RJ
authors.lastname: Dash
mesh_terms: D019386:Alendronate / Q000627:therapeutic use; D000469:Alkaline Phosphatase / Q000097:blood; D001842:Bone and Bones / Q000473:pathology; D002118:Calcium / Q000097:blood / Q000652:urine; D002648:Child; D003404:Creatinine / Q000652:urine; D019587:Dietary Supplements; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D010018:Osteomalacia / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D010710:Phosphates / Q000097:blood / Q000627:therapeutic use / Q000652:urine; D011859:Radiography; D011885:Radius Fractures / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology
chemical_list: D010710:Phosphates; D003404:Creatinine; D000469:Alkaline Phosphatase; D002118:Calcium; D019386:Alendronate