Genetics of autoimmune myasthenia gravis, a model for antibody-mediated autoimmunity in man.
Autoimmune myasthenia gravis is an antibody-mediated autoimmune disease of the neuromuscular junction aimed at the muscle acetylcholine receptor. Recent genetic analyses focusing on a nonclass II HLA-linked locus, MYAS1, and on one of the genes encoding the AChR self-antigen, CHRNA1, are discussed.
Garchon
Henri-Jean
HJ
INSERM U580, 161 rue de Sèvres, 75743 Paris Cedex 15, France. garchon@necker.fr
D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000378:metabolism; D015551:Autoimmunity; D005260:Female; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D008297:Male; D009157:Myasthenia Gravis / Q000235:genetics* / Q000276:immunology; D010641:Phenotype; D011950:Receptors, Cholinergic / Q000235:genetics / Q000378:metabolism; D014429:Twins, Dizygotic / Q000235:genetics; D014430:Twins, Monozygotic / Q000235:genetics
D001323:Autoantibodies; D001324:Autoantigens; D011950:Receptors, Cholinergic