[Oxygen deprivation as the initiator of osteogenesis in hypokinesia].
The hypokinesia initiated on the distrophic changes in the rats' femur bones was studied. The interrupted normobaric hypoxia destructive inhibited possibility in the bone tissue was also investigated. It was shown that inspiration the gaz mixture (nitrogen and oxygen (Po2 = 100-110 mm Hg) normalizes the biochemical markers, greatly minimizes the loss of the secondary spongioza due to the decrease of osteoclastic resorption activity; normalizes the compact bone perepheric layers. The decreased osteoblasts activity in comparison with the control in the metaphysis and the smaller length growth indicate non-complete hypokinesia influence compensation after the oxygen deprivation.
Litovka
I H
IH
A.A. Bogomoletz Institute of Physiology, National Academy of Scinces of Ukraine, Kiev.
Berezovs'ka
O P
OP
D000818:Animals; D001274:Atmospheric Pressure; D001851:Bone Diseases, Metabolic / Q000378:metabolism / Q000503:physiopathology; D005269:Femur / Q000254:growth & development / Q000648:ultrastructure; D018476:Hypokinesia / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D010012:Osteogenesis / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar