Chiral separation of organic phosphonate compounds on cellulose CSP (chiral stationary phase) under reversed phase mode.
The enantiomers of fourteen O,O-dialkyl-2-benzyloxycarbonyl-aminoarylmethyl-phosphonates are directly separated on the tris(3,5-dimethylphenylcarbamate) cellulose column (Chiralcel OD-R) under reversed phase mode. The results of the chiral separation are different from the results obtained in the normal phase mode. The mobile phase plays an essential role in chiral discrimination when using Chiralcel OD-R. The influences of the mobile phase composition on the retention and the enantioselectivity are investigated. The influences on chiral separation of the length and steric hindrance of alkoxy groups of the phosphonate ester and of the nature of the substituent on the benzene ring that is attached to the chiral carbon atom are also discussed.
Yang
Guo-Sheng
GS
Department of Chemistry, Shandong University, Jinan 250100, PR China.
Parrilla Vazquez
Piedad
P
Garrido Frenich
Antonia
A
Martinez Vidal
Jose L
JL
Aboul-Enein
Hassan Y
HY