title: [Disc-like changes and type II collagen mRNA expression in the bilaminar zone of rabbit temporomandibular joint following disc displacement].
abstract: OBJECTIVE
  To study the adaptive alteration in bilaminar zone of rabbits' temporomandibular joint following disc displacement.
  
  
  METHODS
  Twenty-six Japanese white rabbits were used in this study. Among these rabbits,6 were used as controls. The right discs of other 20 rabbits were displaced anteriorly by operation. Four of these rabbits were killedatn 1, 2, 4, 6 and 8 weeks respectively after surgery. The TMJS were studied by HE staining, Alcin bluen staining and in situ detection of type II collagen mRNA expression.
  
  
  RESULTS
  There appeared cartilage metaplasia after one week following disc displacement. Typical chondrocytes could be found in the bilaminar zone. The new chondrocytes expressed type II collagen.
  
  
  CONCLUSIONS
  The bilaminar zone of TMJ will be remodeled following disc displacement and become a disc-like tissue to function as a disc.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, College of Medicine, Zhejiang University, Hangzhou 310006, China.
authors.forename: Zhi-yuan
authors.initials: ZY
authors.lastname: Gu
authors.forename: Ji-an
authors.initials: JA
authors.lastname: Hu
authors.forename: Jian-ying
authors.initials: JY
authors.lastname: Feng
authors.forename: Zhen-kang
authors.initials: ZK
authors.lastname: Zhang
authors.forename: Yin-kai
authors.initials: YK
authors.lastname: Zhang
mesh_terms: D000818:Animals; D024043:Collagen Type II / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D004204:Joint Dislocations / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis; D011817:Rabbits; D019224:Temporomandibular Joint Disc / Q000378:metabolism / Q000473:pathology*; D013705:Temporomandibular Joint Disorders / Q000378:metabolism / Q000473:pathology*
chemical_list: D024043:Collagen Type II; D012333:RNA, Messenger