title: Effects of hachimi-jio-gan (ba-wei-di-huang-wan) on blood flow in the human central retinal artery.
abstract: Hachimi-jio-gan (HJG), a Chinese herbal formula, and a placebo were given to 12 healthy adults, and the changes in blood flow in the central retinal artery were observed with the latest ultrasonic diagnosis device before and after administration. After administration of HJG, the systolic flow velocity, diastolic flow velocity and mean flow velocity in the central retinal artery showed significant increases. No change was observed in vascular resistance. The subjects deemed suitable for use of HJG showed remarkable increases in blood flow. No changes in blood flow velocities and vascular resistance were observed after administration of the placebo. HJG is frequently used in the aged, often with eye diseases such as cataract. It has been reported that a decrease of blood flow in the central retinal artery becomes more marked in proportion to the progress of various eye diseases. As increases in blood flow were obvious in the cases that were treated with HJG, it is suggested that increases in blood flow in the central retinal artery due to HJG give direct evidence supporting the positive effects of HJG on eye diseases.
authors.affiliation: Department of Bioregulatory Function, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Isobe
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Jong-Chol
authors.initials: JC
authors.lastname: Cyong
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002386:Cataract / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005123:Eye / Q000098:blood supply; D005260:Female; D006801:Humans; D008297:Male; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D012016:Reference Values; D012161:Retinal Artery / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D014463:Ultrasonography; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D014665:Vasodilator Agents; C054591:hachimijiogan