title: [Complications of intraoperative radiotherapy and adjuvant chemotherapy in patients with lung cancer].
abstract: A high single dose of radiation can be delivered precisely to tumor or regional metastasis area by means of intraoperative radiation therapy (IORT). A program of combined treatment including radical IORT, postoperative distant gamma-therapy and adjuvant polychemotherapy with cisplatin and etoposide has been developed at the Center. Treatment was given to 43 patients with stage III lung cancer. Complications were reported in 23.3 +/- 6.0%. Prophylactic methods have been worked out to minimize IORT--related postoperative complications. The postoperative lethality rate was 2.3 +/- 1.4%. No program-related hazards have been observed. Complications from adjuvant polychemotherapy were moderate.
authors.affiliation: Research Institute of Oncology, Research Center, Russian Academy of Medical Sciences, Siberian Branch, Tomsk.
authors.forename: B N
authors.initials: BN
authors.lastname: Zyrianov
authors.forename: A A
authors.initials: AA
authors.lastname: Zav'ialov
authors.forename: S V
authors.initials: SV
authors.lastname: Miller
authors.forename: B S
authors.initials: BS
authors.lastname: Khodkevich
authors.forename: S A
authors.initials: SA
authors.lastname: Kolomiets
authors.forename: V A
authors.initials: VA
authors.lastname: Evtushenko
authors.forename: O V
authors.initials: OV
authors.lastname: Cheremisina
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Rudyk
authors.forename: S V
authors.initials: SV
authors.lastname: Tropin
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D002945:Cisplatin / Q000009:adverse effects; D005047:Etoposide / Q000009:adverse effects; D005260:Female; D005720:Gamma Rays; D006801:Humans; D007432:Intraoperative Period; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome
chemical_list: D005047:Etoposide; D002945:Cisplatin