Risperidone-responsive segmental dystonia and pallidal deep brain stimulation.
A 67-year-old man with risperidone-responsive segmental dystonia underwent bilateral deep brain stimulation (DBS) of the globus pallidus internus. Prospectively, the authors assessed the Burke-Fahn-Marsden Dystonia Rating Scale in medication (M) and stimulation (S) "on"/"off" states. With DBS at 9 months, the score improved by 86% to 8.5 in M-"on"/S-"on" and 12.5 in M-"off"/S-"on." Studies of the effects of DBS and concomitant medication may be warranted in selected patients treated by DBS for dystonia.
Wöhrle
J C
JC
Departments of Neurology,Universitätsklinikum, Mannheim, Germany. woehrle@neuro.ma.uni-heidelberg.de
Weigel
R
R
Grips
E
E
Blahak
C
C
Capelle
H H
HH
Krauss
J K
JK
D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003511:Cyclohexanols / Q000627:therapeutic use; D003863:Depression / Q000139:chemically induced / Q000188:drug therapy; D018492:Dopamine Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D020821:Dystonic Disorders / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D004599:Electric Stimulation Therapy; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010302:Parkinson Disease, Secondary / Q000139:chemically induced; D018967:Risperidone / Q000009:adverse effects / Q000627:therapeutic use*; D012720:Severity of Illness Index; D000069470:Venlafaxine Hydrochloride
D000928:Antidepressive Agents; D003511:Cyclohexanols; D018492:Dopamine Antagonists; D000069470:Venlafaxine Hydrochloride; D018967:Risperidone