[The inhibitory effect of total flavonoids of hippophae on the activation of NF-kappa B by stretching cultured cardiac myocytes].
OBJECTIVE
To investigate the effect of total flavonoids of hippophae (TFH) on the improvement in myocardial hypertrophy.


METHODS
Immunohistochemical method was used to assess the inhibitory effect of TFH on the activation of NF-kappa B by stretching cultured cardiac myocytes.


RESULTS
It was found that NF-kappa B was activated by stretching cardiac myocytes in 10 hours; that TFH at the concentration of 1:400 partly inhibited the activation of NF-kappa B by stretching in cardiac myocytes; that TFH at the concentration of 1:200 and 1:100 completely inhibited the activation of NF-kappa B by stretching in cardiac myocytes.


CONCLUSIONS
The results supported that the blockade of activation of NF-kappa B might be a potential access to the improvement in myocardial function with the use of TFH for treatment of hypertension and chronic cardiac insufficiency.
Xiao
Zhun
Z
Biomedical Engineering Department, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Peng
Wenzhen
W
Zhu
Bin
B
Wang
Zhengrong
Z
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D047309:Flavones; D005419:Flavonoids / Q000494:pharmacology*; D031281:Hippophae / Q000737:chemistry*; D008465:Mechanoreceptors / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000473:pathology*; D016328:NF-kappa B / Q000378:metabolism*; D051381:Rats; D012026:Reflex, Stretch
D004365:Drugs, Chinese Herbal; D047309:Flavones; D005419:Flavonoids; D016328:NF-kappa B; C043562:flavone