title: Serum Levels of IL-4, IL-10, IL-12, IL-13 and IFN-gamma in Behçet's disease.
abstract: Behçet's disease (BD) is an inflammatory disease of unknown etiology. Although its pathogenesis is not fully understood, recent studies have suggested that immunological abnormalities and neutrophil hyperfunction may be involved in its etiology and pathophysiology. The immune system in BD can be characterized as a divergent cytokine production profile of the mixed Th1/Th2 cell type. In this study, we investigated the levels of interleukin (IL)-4, IL-10, IL-12, IL-13 and interferon-g in the sera of patients with BD, in comparison with recurrent aphthous stomatitis and healthy controls, to determine the Th1/Th2 profile of the disease. The levels of IL-4, IL-10 and IL-13 were found to be high in active BD patients, and IL-12 and interferon-gamma levels were lower in active BD patients than in inactive BD, recurrent aphthous stomatitis, and control patients.
authors.affiliation: Department of Microbiology, Faculty of Medicine, University of Suleyman Demirel, Isparta, Turkey.
authors.forename: Buket Cicioglu
authors.initials: BC
authors.lastname: Aridogan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yildirim
authors.forename: Vahide
authors.initials: V
authors.lastname: Baysal
authors.forename: H Serhat
authors.initials: HS
authors.lastname: Inaloz
authors.forename: Kiymet
authors.initials: K
authors.lastname: Baz
authors.forename: Selcuk
authors.initials: S
authors.lastname: Kaya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001528:Behcet Syndrome / Q000097:blood / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013281:Stomatitis, Aphthous / Q000097:blood / Q000150:complications / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D007378:Interleukins; D007371:Interferon-gamma