[Nitrite reductase activity of deoxyhemoglobin in diabetes and its correction by nicotinamide].
The increase of deoxyhemoglobin nitrite-reductase activity was established at streptozotocin-induced diabetes in rats. The deoxyhemoglobin nitrosilation in the streptozotocin-induced diabetic rats was shown to increase the optical density in the aromatic acid region and cause additional absorption peak at 334 nm. The two-week injection of nicotinamide causes reduction in the nitrite reductase activity of the deoxyhemoglobin and the absorption peak at 334 nm disappearance.
Korobov
V M
VM
Ivan Franko Lviv State University, Ukraine.
Biront
N V
NV
Fedorovych
A M
AM
Burda
V A
VA
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D006454:Hemoglobins / Q000378:metabolism*; D009536:Niacinamide / Q000627:therapeutic use*; D009572:Nitrite Reductases / Q000378:metabolism*; D051381:Rats; D013057:Spectrum Analysis
D006454:Hemoglobins; D009536:Niacinamide; C100003:deoxyhemoglobin; D009572:Nitrite Reductases