title: Hypodiploidy of 37 chromosomes in an adult patient with acute lymphoblastic leukemia.
abstract: We present a 42-year-old man with acute lymphoblastic leukemia and hypodiploidy at diagnosis. Chromosome count was 37, with a mixture of numerical and structural abnormalities. The patient died 9 months post diagnosis, during which time three further cytogenetic tests were performed. The core abnormalities seen upon diagnosis were present at 7 and 9 months after diagnosis, with a duplication of the abnormal hypodiploid karyotype on the last specimen. While considerable imbalances were present as a result of whole chromosome aneuploidy, no region was obviously nullisomic.
authors.affiliation: Department of Haematology and Bone Marrow Transplantation, Westmead Hospital, Westmead, Australia.
authors.forename: P K
authors.initials: PK
authors.lastname: Das
authors.forename: P
authors.initials: P
authors.lastname: Sharma
authors.forename: J
authors.initials: J
authors.lastname: Koutts
authors.forename: A
authors.initials: A
authors.lastname: Smith
mesh_terms: D000328:Adult; D000782:Aneuploidy; D001854:Bone Marrow Cells / Q000166:cytology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*