title: Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species.
abstract: Bioassay-guided fractionation resulted in the isolation of four antifungal agents from the roots of Cudrania cochinchinensis. Two of these were new compounds, cudraxanthone S [1, 1,3,5,6-tetrahydroxy-2-(1,1-dimethyl-2-propenyl)xanthone] and cudraflavanone B (2, 2',4',5,7-tetrahydroxy-6-prenylflavanone). The remaining two compounds were known compounds, toxyloxanthone C (3) and wighteone (4). Among these compounds, 1, 3, and 4 exhibited antifungal activities against Cryptococcus neoformans, Aspergillusfumigatus, and A. nidulans (MICs = 2-8 microg/mL). Compounds 1 and 3 also showed antifungal activity against Candida glabrata (MICs = 4-8 microg/mL).
authors.affiliation: School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. fukai@phar.tohu-u.ac.jp
authors.forename: Toshio
authors.initials: T
authors.lastname: Fukai
authors.forename: Makiko
authors.initials: M
authors.lastname: Yonekawa
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Hou
authors.forename: Taro
authors.initials: T
authors.lastname: Nomura
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Uno
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects*; D002175:Candida / Q000187:drug effects*; D003454:Cryptococcus / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D004365:Drugs, Chinese Herbal; D044004:Xanthones