[Hypoglycemic activity of derivatives of succinic acid amides and hydrazides].
A series of 20 substituted amides and hydrazides of succinic acid were synthesized and studied with respect to their action upon the blood glucose level in intact rats. The structure-activity relationship is considered. Substances exhibiting maximum hypoglycemic activity were additionally characterized by the acute toxicity and the hypoglycemic effect on the model of alloxan diabetes in rats. It was found that 4-aminobenzoyl hydrazide is more effective and less toxic than the reference compounds metformin and glyclazide.
Dolzhenko
A V
AV
Physiology Department and Analytical Chemistry Department, Perm State Pharmaceutical Academy, ul. Lenina 48, Perm, 641990 Russia.
Kotegov
V P
VP
Godina
A T
AT
Syropiatov
B Ia
BIa
Kolotova
N V
NV
Koz'minykh
V O
VO
D000577:Amides / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002087:Butyrates / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D005260:Female; D006834:Hydrazines / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship; D023382:Toxicity Tests, Acute
D000577:Amides; D001786:Blood Glucose; D002087:Butyrates; D006834:Hydrazines; D007004:Hypoglycemic Agents