Serum levels of intercellular adhesion molecule-1 correlate with advanced and metastatic disease and poor prognosis in gastric cancer.
OBJECTIVE
The aim of this study was to compare the levels of intercellular adhesion molecule-1 in gastric cancer patients and healthy controls and to evaluate their clinical significance.


METHODS
The serum levels of the intercellular adhesion molecule-1 were measured in 53 patients with gastric cancer and in 39 healthy controls by an enzyme linked immunosorbent assay and were associated with clinicopathological features, patient survival and established tumor markers.


RESULTS
Serum levels of intercellular adhesion molecule-1 in patients with gastric cancer were significantly higher in comparison with healthy controls. These levels correlated with tumor stage, and with lymph node and distant metastases. Elevated serum levels of intercellular adhesion molecule-1 were a significant prognostic factor for poor survival but not independent of disease stage and type of resection. Elevated serum ICAM-1 levels correlated significantly with both elevated serum CA 19-9 and elevated CEA levels.


CONCLUSIONS
Serum levels of intercellular adhesion molecule-1 in gastric cancer patients correlate with advanced and metastatic disease and with poor prognosis although their use as tumor markers remains to be determined.
Polychronidis
Alexandros C
AC
Second Department of Surgery, Democritus University of Thrace, Medical School, Alexandroupolis, Greece. polych@med.duth.gr
Tsaroucha
Alexandra K
AK
Samolis
Sofoklis P
SP
Botaitis
Sotirios K
SK
Perente
Sebachedin S
SS
Simopoulos
Constantinos E
CE
D000230:Adenocarcinoma / Q000097:blood* / Q000401:mortality / Q000556:secondary; D000368:Aged; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood* / Q000276:immunology; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology; D016019:Survival Analysis; D015996:Survival Rate
D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D018799:Intercellular Adhesion Molecule-1