[Polymorphism of xenobiotic detoxication genes in patients with iron deficiency anemia].
Polymorphism of genes of cytochrome P-4501A1 (CYP1A1), of glutathione S-transferase M1 (GSTM1), and of N-acetyltransferase 2 (Nat2) was investigated in 102 patients with iron-deficiency anemia (IDA) and in 105 virtually healthy persons (control group). A prevalence of a mutant form of gene CYP1A1 was found in patients with IDA versus the controls. Combinations of genotypes according to polymorphous systems of CYP1A1, GSTM1 and Nat2 were detected, which is typical of IDA patients and which can be used as molecular-genetic markers of the disease.
Safuanova
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D000293:Adolescent; D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000378:metabolism*; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008658:Inactivation, Metabolic; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015262:Xenobiotics / Q000493:pharmacokinetics*
D001191:Arylamine N-Acetyltransferase; D019363:Cytochrome P-450 CYP1A1; D005819:Genetic Markers; D005982:Glutathione Transferase; D015262:Xenobiotics; C478900:NAT2 protein, human