title: A regressive model analysis of congenital sensorineural deafness in German Dalmatian dogs.
abstract: The objective of the present study was to analyze the mode of inheritance for congenital sensorineural deafness (CSD) in German Dalmatian dogs by consideration of association between phenotypic breed characteristics and CSD. Segregation analysis with regressive logistic models was employed to test for different mechanisms of genetic transmission. Data were obtained from all three Dalmatian kennel clubs associated with the German Association for Dog Breeding and Husbandry (VDH). CSD was tested by veterinary practitioners using standardized protocols for Brainstem Auditory-Evoked Response (BAER). The sample included 1899 Dalmatian dogs from 354 litters in 169 different kennels. BAER testing results were from the years 1986 to 1999. Pedigree information was available for up to seven generations. The segregation analysis showed that a mixed monogenic-polygenic model including eye color as covariate among all other tested models best explained the segregation of affected animals in the pedigrees. The recessive major gene segregated in dogs with blue and brown eye color as well as in dogs with and without pigmented coat patches. Models which took into account the occurrence of patches, percentage of puppies tested per litter, or inbreeding coefficient gave no better adjustment to the most general (saturated) model. A procedure for the simultaneous prediction of breeding values and the estimation of genotype probabilities for CSD is expected to improve breeding programs significantly.
authors.affiliation: Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Buenteweg 17p, 30559 Hannover, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Juraschko
authors.forename: Andrea
authors.initials: A
authors.lastname: Meyer-Lindenberg
authors.forename: Ingo
authors.initials: I
authors.lastname: Nolte
authors.forename: Ottmar
authors.initials: O
authors.lastname: Distl
mesh_terms: D000818:Animals; D001947:Breeding / Q000379:methods; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005127:Eye Color / Q000235:genetics; D005858:Germany; D006197:Hair; D006319:Hearing Loss, Sensorineural / Q000235:genetics / Q000662:veterinary*; D040582:Inheritance Patterns / Q000235:genetics*; D016015:Logistic Models; D010375:Pedigree; D010858:Pigmentation / Q000235:genetics; D012044:Regression Analysis; D012737:Sex Factors