title: [Effect of nooglutil on rats with intracerebral posttraumatic hematoma (hemorrhagic stroke)].
abstract: The effect of the new nootropic drug nooglutyl, a positive modulator of AMPA-subtype glutamatergic receptors, was studied in rats with a model hemorrhagic stroke (HS)--posttraumatic hematoma induced by cerebral tissue destruction in the capsule interna region. Single intraperitoneal injections of nooglutyl (10 and 20 mg/kg) 3-4 h after operation decreased the HS-induced neurological deficiency, restored the coordination of movements, improved the passive avoidance reaction retrieval, and prevented the loss of experimental animals. The results show evidence of a pronounced neuroprotector action of nooglutyl in rats with the HS model.
authors.affiliation: Laboratory of Psychopharmacology, Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
authors.forename: T L
authors.initials: TL
authors.lastname: Garibova
authors.forename: I P
authors.initials: IP
authors.lastname: Galaeva
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
authors.forename: V A
authors.initials: VA
authors.lastname: Kraĭneva
authors.forename: I G
authors.initials: IG
authors.lastname: Kapitsa
authors.forename: S V
authors.initials: SV
authors.lastname: Kirichenko
authors.forename: A N
authors.initials: AN
authors.lastname: Makarenko
authors.forename: G R
authors.initials: GR
authors.lastname: Mirzoian
authors.forename: E A
authors.initials: EA
authors.lastname: Kuznetsova
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D020202:Cerebral Hemorrhage, Traumatic / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D003213:Conditioning, Psychological / Q000187:drug effects; D005971:Glutamates / Q000627:therapeutic use*; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009539:Nicotinic Acids / Q000627:therapeutic use*; D051381:Rats
chemical_list: D005971:Glutamates; D018696:Neuroprotective Agents; D009539:Nicotinic Acids; C066295:nooglutil