First one-pot copper-catalyzed synthesis of alpha-hydroxy-beta-amino acids in water. A new protocol for preparation of optically active norstatines.
Alpha-hydroxy-beta-amino acids were synthesized with excellent yields for the first time in water and by a simple procedure based on a copper catalytic cycle, which included the recovery and reuse of the catalyst and is possible to realize by using only water as reaction medium.
Fringuelli
Francesco
F
Dipartimento di Chimica, Università di Perugia, 06123 Perugia, Italy. firfra@unipg.it
Pizzo
Ferdinando
F
Rucci
Mauro
M
Vaccaro
Luigi
L
D000596:Amino Acids / Q000138:chemical synthesis*; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000596:Amino Acids; D001386:Azides; D008670:Metals; D014867:Water; D003300:Copper