Hereditary ovarian cancer in Poland.
There is increasing evidence that hereditary factors play a greater role in ovarian cancer than in any of the other common cancers of adulthood. This is attributable, to a large extent, to a high frequency of mutations in the BRCA1 or BRCA2 genes. In Poland, 3 common founder mutations in BRCA1 account for the majority of families with identified BRCA mutations. Our study was conducted in order to estimate the prevalence of any of 3 founder BRCA1 mutations (5382insC, C61G and 4153delA) in 364 unselected women with ovarian cancer, and among 177 women with ovarian cancer and a family history of breast or ovarian cancer. A mutation was identified in 49 out of 364 unselected women with ovarian cancer (13.5%) and in 58 of 177 women with familial ovarian cancer (32.8%). The majority of women with ovarian cancer and a BRCA1 mutation have no family history of breast or ovarian cancer. The high frequency of BRCA1 mutations in Polish women with ovarian cancer supports the recommendation that all Polish women with ovarian cancer should be offered testing for genetic susceptibility, and that counseling services be made available to them and to their relatives. It is important that mutation surveys be conducted in other countries prior to the introduction of national genetic screening programs.
Menkiszak
Janusz
J
Department of Surgical Gynecology and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland. janusz@sz.home.pl
Gronwald
Jacek
J
Górski
Bohdan
B
Jakubowska
Anna
A
Huzarski
Tomasz
T
Byrski
Tomasz
T
Foszczyńska-Kłoda
Małgorzata
M
Haus
Olga
O
Janiszewska
Hanna
H
Perkowska
Magdalena
M
Brozek
Izabela
I
Grzybowska
Ewa
E
Zientek
Helena
H
Góźdź
Stanisław
S
Kozak-Klonowska
Beata
B
Urbański
Krzysztof
K
Miturski
Roman
R
Kowalczyk
Jerzy
J
Pluzańska
Anna
A
Niepsuj
Stanisław
S
Koc
Jan
J
Szwiec
Marek
M
Drosik
Kazimierz
K
Mackiewicz
Andrzej
A
Lamperska
Katarzyna
K
Strózyk
Elwira
E
Godlewski
Dariusz
D
Stawicka
Małgorzata
M
Waśko
Bernard
B
Bebenek
Marek
M
Rozmiarek
Andrzej
A
Rzepka-Górska
Izabella
I
Narod
Steven A
SA
Lubiński
Jan
J
D024682:BRCA2 Protein / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011044:Poland / Q000453:epidemiology; D015995:Prevalence
D024682:BRCA2 Protein; D009363:Neoplasm Proteins