Selective deficiency of naïve CD4+ T-lymphocytes in a child with congenital lymphoedema.
We describe the first known case of congenital lymphoedema associated with selective deficit of naïve CD4+ T-lymphocytes. A high proportion of naïve CD4+ T-lymphocytes was found in the ascitic fluid, supporting the hypothesis of extra-vascular sequestration of these cells into lymphoedematous tissue.
Chiappini
Elena
E
Division of Paediatrics and Infectious Diseases, Department of Paediatrics, University of Florence, Via Luca Giordano 13, 50132 Florence, Italy.
Galli
Luisa
L
Giudizi
Maria Grazia
MG
Azzari
Chiara
C
Niccoli
Augusto Antonio
AA
Romagnani
Sergio
S
de Martino
Maurizio
M
D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D000013:Congenital Abnormalities / Q000175:diagnosis; D006801:Humans; D007223:Infant; D007558:Italy; D019041:L-Selectin / Q000378:metabolism*; D008209:Lymphedema / Q000151:congenital* / Q000175:diagnosis*; D008297:Male; D011379:Prognosis; D035583:Rare Diseases; D018570:Risk Assessment
D019041:L-Selectin