Nicotinamide ribosyl uptake mutants in Haemophilus influenzae.
The gene for the nicotinamide riboside (NR) transporter (pnuC) was identified in Haemophilus influenzae. A pnuC mutant had only residual NR uptake and could survive in vitro with high concentrations of NR, but could not survive in vivo. PnuC may represent a target for the development of inhibitors for preventing H. influenzae disease.
Herbert
Mark
M
Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom. mherbert@molbiol.ox.ac.uk
Sauer
Elizabeta
E
Smethurst
Graeme
G
Kraiss
Anita
A
Hilpert
Anna-Karina
AK
Reidl
Joachim
J
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D001693:Biological Transport, Active; D004269:DNA, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D005816:Genetic Complementation Test; D006192:Haemophilus Infections / Q000209:etiology / Q000382:microbiology; D006193:Haemophilus influenzae / Q000235:genetics* / Q000378:metabolism*; D007700:Kinetics; D009154:Mutation; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000378:metabolism*; D011726:Pyridinium Compounds
D001426:Bacterial Proteins; D004269:DNA, Bacterial; C422464:NadV protein, Haemophilus ducreyi; D011726:Pyridinium Compounds; C018613:nicotinamide-beta-riboside; D009536:Niacinamide