title: Self-organizing molecular field analysis on alpha(1a)-adrenoceptor dihydropyridine antagonists.
abstract: Self-organizing molecular field analysis (SOMFA), a new three-dimensional quantitative structure-activity relationship (3-D-QSAR) method is used to study the correlation between the molecular properties and the alpha(1a)-AR biological activities of dihydropyridine derivatives. The statistical result, cross-validated q(2) (0.690) and non cross-validated r(2) (0.704) values, show a good predictive ability.
authors.affiliation: .Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Minyong
authors.initials: M
authors.lastname: Li
authors.forename: Lüpei
authors.initials: L
authors.lastname: Du
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.forename: Lin
authors.initials: L
authors.lastname: Xia
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000737:chemistry* / Q000494:pharmacology; D004095:Dihydropyridines / Q000737:chemistry* / Q000494:pharmacology; D008962:Models, Theoretical; D021281:Quantitative Structure-Activity Relationship; D015203:Reproducibility of Results; D055672:Static Electricity; D013223:Statistics as Topic
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D004095:Dihydropyridines