title: Effect of Sinomenine on IL-8, IL-6, IL-2 produced by peripheral blood mononuclear cells.
abstract: The effect of Sinomenine on IL-8, IL-6, IL-2 and mIL-2R produced by peripheral blood mononuclear cells was investigated by using cell culture, radioimmunoassay and flow cytometry. It was showed that production of IL-8 and mIL-2R was inhibited, but the levels of IL-6 were enhanced by Sinomenine. Our results also demonstrated that Sinomenine did not have any effect on the production of IL-2. The study demonstrated that Sinomenine was able to regulate the production of cytokines. This may be one of the mechanisms by which Sinomenine works on rheumatoid arthritis.
authors.affiliation: Department of Traditional Chinese Medicine, Tongji Hospital, Tongji Medical University, Wuhan 430030.
authors.forename: S
authors.initials: S
authors.lastname: Tu
authors.forename: Y
authors.initials: Y
authors.lastname: Hu
authors.forename: F
authors.initials: F
authors.lastname: Lu
mesh_terms: D018501:Antirheumatic Agents / Q000494:pharmacology*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D006801:Humans; D007376:Interleukin-2; D015850:Interleukin-6; D016209:Interleukin-8; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D009019:Morphinans / Q000494:pharmacology*
chemical_list: D018501:Antirheumatic Agents; D007376:Interleukin-2; D015850:Interleukin-6; D016209:Interleukin-8; D009019:Morphinans; C009271:sinomenine