title: New monordens produced by amidepsine-producing fungus Humicola sp. FO-2942.
abstract: Based on UV spectrum-guided purification, new monordens C, D and E, known monordens A (radicicol) and B and 5-O-methylsclerone were isolated from the fermentation broth of amidepsine-producing Humicola sp. FO-2942 by solvent extraction, silica-gel column chromatography, ODS column chromatography and HPLC. All monordens cause the cell cycle arrest at G1 and G2/M phases in Jurkat cells. But among them, monordens A and E show antifungal activity only against Aspergillus niger.
authors.affiliation: Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Arai
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Ichiji
authors.initials: I
authors.lastname: Namatame
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D005285:Fermentation; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents