title: Sulfemodin 8-O-beta-D-glucoside, a new sulfated anthraquinone glycoside, and antioxidant phenolic compounds from Rheum emodi.
abstract: A sulfated emodin glucoside, emodin 8-O-beta-D-glucopyranosyl-6-O-sulfate (1), was isolated from the roots of Rheum emodi in an investigation of the active constituents of this Nepalese medicinal plant, and its structure was determined by spectroscopic and chemical methods. Additionally, two rare auronols, carpusin (2) and maesopsin (3), besides other anthraquinones and phenolics, were isolated and identified. Compounds 2 and 3 showed significant antioxidant activity in the DPPH assay, while chrysophanol, physcion, and emodin and their 8-O-glucosides were found to be inactive.
authors.affiliation: Institute of Pharmacognosy, University of Vienna, Pharmacy-Center, Althanstrasse 14, A-1090 Vienna, Austria.
authors.forename: Liselotte
authors.initials: L
authors.lastname: Krenn
authors.forename: Armin
authors.initials: A
authors.lastname: Presser
authors.forename: Riddhi
authors.initials: R
authors.lastname: Pradhan
authors.forename: Beate
authors.initials: B
authors.lastname: Bahr
authors.forename: Dietrich H
authors.initials: DH
authors.lastname: Paper
authors.forename: Klaus K
authors.initials: KK
authors.lastname: Mayer
authors.forename: Brigitte
authors.initials: B
authors.lastname: Kopp
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009390:Nepal; D019906:Nuclear Magnetic Resonance, Biomolecular; D010851:Picrates / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012250:Rheum / Q000737:chemistry*
chemical_list: D000880:Anthraquinones; D000975:Antioxidants; D001572:Benzofurans; D001713:Biphenyl Compounds; D006027:Glycosides; D010851:Picrates; C479846:sulfemodin 8-O-beta-D-glucopyranosyl-6-O-sulfate; C107973:maesopsin; C004931:1,1-diphenyl-2-picrylhydrazyl