Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma.
Tropomyosin 1 (TM1) is downregulated in a number of transformed cell types, and exogenous expression of TM1 can restore actin organisation and reverse cellular transformation. We find that TM1 is also downregulated in human neuroblastoma cell lines, correlating with increasing malignancy. However, exogenous TM1 does not restore actin cytoskeleton organisation in neuroblastoma cells.
Yager
M L
ML
The Oncology Research Unit, The Children's Hospital at Westmead, Locked Bag 4001, Westmead 2145, NSW, Australia.
Hughes
J A I
JA
Lovicu
F J
FJ
Gunning
P W
PW
Weinberger
R P
RP
O'Neill
G M
GM
D000199:Actins / Q000648:ultrastructure; D015153:Blotting, Western; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D003599:Cytoskeleton / Q000502:physiology* / Q000648:ultrastructure; D015536:Down-Regulation; D029721:Drosophila Proteins; D005455:Fluorescent Antibody Technique; D006801:Humans; D009447:Neuroblastoma / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis; D014162:Transfection; D014335:Tropomyosin / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000199:Actins; D029721:Drosophila Proteins; D016271:Proto-Oncogene Proteins c-myc; C490775:TPM1 protein, human; C097163:Tm2 protein, Drosophila; D014335:Tropomyosin