title: [Successful treatment with foscarnet for disseminated varicella-zoster infection after reduced intensity stem cell transplantation in a case of relapsed refractory central nervous system lymphoma].
abstract: Visceral disseminated varicella-zoster virus (VZV) infection occurred with acute graft-versus-host disease in a 33-year-old Japanese male with non-Hodgkin lymphoma who had undergone allogeneic stem cell transplantation from an HLA-identical sibling after reduced intensity conditioning chemotherapy. Although ganciclovir and acyclovir treatment was effective temporarily, the number of VZV-DNA copies in the blood remained at a high level, and the hepatitis was prolonged. The patient was treated with foscarnet, which led to improvement of the VZV viremia and the hepatic dysfunction. Foscarnet therapy should be considered for acyclovir-resistant VZV infection in the setting of allogeneic hematopoietic stem cell transplantation.
authors.affiliation: Graduate School of Medicine, Osaka City University.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Aoyama
authors.forename: Ryousuke
authors.initials: R
authors.lastname: Yamamura
authors.forename: Etsuko
authors.initials: E
authors.lastname: Shima
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Nakamae
authors.forename: Kaori
authors.initials: K
authors.lastname: Makita
authors.forename: Taro
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Chikahiko
authors.initials: C
authors.lastname: Sakamoto
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Terada
authors.forename: Genzyu
authors.initials: G
authors.lastname: Kho
authors.forename: Kensuke
authors.initials: K
authors.lastname: Ohta
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamane
authors.forename: Takayuki
authors.initials: T
authors.lastname: Takubo
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hino
mesh_terms: D000212:Acyclovir / Q000494:pharmacology; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D016543:Central Nervous System Neoplasms / Q000150:complications / Q000628:therapy*; D024882:Drug Resistance, Viral; D017245:Foscarnet / Q000627:therapeutic use*; D006086:Graft vs Host Disease / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006562:Herpes Zoster / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000628:therapy*; D008297:Male; D012008:Recurrence; D014184:Transplantation, Homologous
chemical_list: D000998:Antiviral Agents; D017245:Foscarnet; D000212:Acyclovir