title: Acromegaly with multiple cardiovascular complications--cardiomyopathy, chordae rupture of mitral valve, myocardial infarction and sick sinus syndrome.
abstract: A 62-year-old woman had acromegaly and developed congestive heart failure with cardiomyopathy, mitral regurgitation due to chordae rupture, coronary artery disease and sick sinus syndrome. Since congestive heart failure was resistant to medical therapy, mitral valve replacement, aortocoronary bypass surgery and implantation of permanent pacemaker were performed one month after her admission. Although acromegalic patients with cardiomyopathy are usually resistant to therapy, we successfully treated the patient by the surgeries. It appears that all these diseases resulted from an elevated plasma concentration of growth hormone. Untreated acromegaly for more than ten years may contribute to multiple complications such as those in the present patient.
authors.affiliation: Department of Cardiology, Kinki University School of Medicine, Osakasayama.
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakamura
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ogawa
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Saga
authors.forename: Kinji
authors.initials: K
authors.lastname: Ishikawa
mesh_terms: D000172:Acromegaly / Q000097:blood / Q000150:complications* / Q000503:physiopathology*; D002304:Cardiac Pacing, Artificial / Q000379:methods; D009202:Cardiomyopathies / Q000209:etiology / Q000601:surgery*; D001026:Coronary Artery Bypass / Q000379:methods; D005260:Female; D013006:Growth Hormone / Q000009:adverse effects* / Q000097:blood; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006801:Humans; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000209:etiology / Q000601:surgery*; D009203:Myocardial Infarction / Q000209:etiology / Q000601:surgery*; D012804:Sick Sinus Syndrome / Q000209:etiology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D013006:Growth Hormone