Ultralow doses of anti-idiotypic antibodies to human gamma-interferon: immunotropic properties.
We studied the effects of ultralow doses of anti-idiotypic antibodies to human gamma-interferon on humoral immune response in experimental animals immunized with a thymus-dependent antigen, delayed-type hypersensitivity, and phagocytic activity of neutrophils in the peritoneal exudate. This preparation stimulated the humoral immune response and activated phagocytosis, but had no effect on functional activity of T cells.
Sherstoboev
E Yu
EY
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk.
Masnaya
N M
NM
Churin
A A
AA
Borsuk
O S
OS
Martyushev
A V
AV
Epstein
O I
OI
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007371:Interferon-gamma / Q000276:immunology*; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D007371:Interferon-gamma