Alterations in brain metabolism induced by chronic morphine treatment: NMR studies in rat CNS.
High-resolution (500 MHz) multiresonance/multinuclear proton (1H) nuclear magnetic resonance (NMR) spectroscopy was used to detect metabolic changes and cellular injury in the rat brain stem and spinal cord following chronic morphine treatment. Compensatory changes were observed in glycine, glutamate, and inositols in the brain stem, but not the spinal cord, of chronic morphine-treated rats. In spinal cord, increases were detected in lactate and N-acetyl-aspartate (NAA), suggesting that there is anaerobic glycolysis, plasma membrane damage, and altered pH preferentially in the spinal cord of chronic morphine-treated rats.
Sharma
Sushil K
SK
Department of Physiology, McGill University, Montreal, Quebec, Canada.
Yashpal
Kiran
K
Fundytus
Marian E
ME
Sauriol
Françoise
F
Henry
James L
JL
Coderre
Terence J
TJ
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009020:Morphine / Q000009:adverse effects / Q000494:pharmacology*; D051381:Rats; D020318:Rats, Long-Evans; D013116:Spinal Cord / Q000187:drug effects* / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000378:metabolism
D009020:Morphine