Endocrine aspects of coeliac disease.
Coeliac disease (CD) is a permanent intolerance to gluten that results in damage of the small intestinal mucosa, and it is one of the common causes of chronic malabsorption in children. It is well known that patients with CD are at great risk of malignant complications, but in patients with CD many other disorders have been recognized. Autoimmunity diseases, such as type 1 diabetes mellitus, thyroid diseases, and autoimmune polyglandular syndromes are known to be associated with CD, and they seem to be related to gluten exposure. Growth, bone metabolism, and fertility can be affected in patients with CD, especially if they are not on a gluten-free diet. We review the literature on endocrine aspects of CD, because patients with CD are at great risk of developing endocrine disorders.
Iughetti
Lorenzo
L
Department of Pediatrics, University of Modena & Reggio Emilia, Italy.
Bulgarelli
Sabrina
S
Forese
Silvia
S
Lorini
Renata
R
Balli
Fiorella
F
Bernasconi
Sergio
S
D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D001842:Bone and Bones / Q000378:metabolism; D002446:Celiac Disease / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D004702:Endocrine Glands / Q000503:physiopathology*; D004700:Endocrine System Diseases / Q000150:complications; D005260:Female; D005831:Genital Diseases, Female / Q000150:complications; D005983:Glutens / Q000276:immunology; D006130:Growth Disorders / Q000503:physiopathology; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications
D005983:Glutens