title: PEHO and PEHO-like syndromes: report of five Australian cases.
abstract: PEHO syndrome is a rare progressive infantile encephalopathy with onset within the first few months of life. Few patients fulfilling the diagnostic criteria for PEHO syndrome have been reported outside Finland. Affected infants have facial dysmorphism and suffer from severe hypotonia, profound mental retardation, convulsions (often with a hypsarrhythmic EEG pattern), transient or persistent peripheral oedema, and optic atrophy. Cerebellar and brainstem atrophy are usually present on neuroimaging. A PEHO-like syndrome has been described, in which the affected individuals have neither optic atrophy nor the typical neuroradiological findings. We report five Australian patients, the first with classical features of PEHO syndrome, and four who have a PEHO-like disorder. We compare their features with other published cases. We suggest that PEHO or a PEHO-like syndrome may affect more patients than are currently identified, based on the original diagnostic criteria for this disorder.
authors.affiliation: Department of Clinical Genetics, The Children's Hospital at Westmead, New South Wales, Australia. mfield@ivf.com.au
authors.forename: M J
authors.initials: MJ
authors.lastname: Field
authors.forename: P
authors.initials: P
authors.lastname: Grattan-Smith
authors.forename: S M
authors.initials: SM
authors.lastname: Piper
authors.forename: E M
authors.initials: EM
authors.lastname: Thompson
authors.forename: E A
authors.initials: EA
authors.lastname: Haan
authors.forename: M
authors.initials: M
authors.lastname: Edwards
authors.forename: S
authors.initials: S
authors.lastname: James
authors.forename: I
authors.initials: I
authors.lastname: Wilkinson
authors.forename: L C
authors.initials: LC
authors.lastname: Adès
mesh_terms: D020739:Brain Diseases, Metabolic, Inborn / Q000235:genetics / Q000503:physiopathology*; D002675:Child, Preschool; D004487:Edema / Q000235:genetics / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009896:Optic Atrophy / Q000235:genetics / Q000503:physiopathology*; D013036:Spasms, Infantile / Q000235:genetics / Q000503:physiopathology*