title: Batch and simulated moving bed chromatographic resolution of a pharmaceutical racemate.
abstract: The preparative chromatographic resolution of racemates has become over the past few years a standard approach for the generation of enantiomers in pharmaceutical research and development. This paper will discuss the chromatographic resolution of a racemic pharmaceutical intermediate. Initial analytical method development to determine the best preparative conditions will be presented. Batch resolution of kg quantities of racemate followed by the simulated moving bed resolution of tens and hundreds of kg of racemate will also be discussed. Finally the different approaches used for the separation will be compared.
authors.affiliation: Pharmacia, 4901 Searle Parkway, Skokie, IL, USA. lawrence.m.miller@pharmacia.com
authors.forename: Larry
authors.initials: L
authors.lastname: Miller
authors.forename: Charles
authors.initials: C
authors.lastname: Grill
authors.forename: Tony
authors.initials: T
authors.lastname: Yan
authors.forename: Olivier
authors.initials: O
authors.lastname: Dapremont
authors.forename: Elke
authors.initials: E
authors.lastname: Huthmann
authors.forename: Markus
authors.initials: M
authors.lastname: Juza
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods; D004364:Pharmaceutical Preparations / Q000302:isolation & purification*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D004364:Pharmaceutical Preparations