title: [Allergic reaction against an emulsifier, HCO-60, contained in multamin and enocitabine].
abstract: We report two cases of an allergic reaction to HCO-60, which is used as an emulsifien for Multamin and enocitabine. A 55-year-old woman with M 4 Eo developed a high fever, urticaria and erythema after induction chemotherapy. After stopping the administration of Multamin, her fever and eruptions subsided. A 51-year-old woman with L 2 developed erythema and hypotension 30 minutes after the third administration of Multamin. When the patient was given enocitabine, she developed anaphylactic shock. During chemotherapy in patients with leukemia, it is important to distinguish the allergic reaction against Multamin-containing HCO-60 from infection and allergies to other drugs.
authors.affiliation: Department of Internal Medicine II, Kumamoto University School of Medicine.
authors.forename: Hiro
authors.initials: H
authors.lastname: Tatetsu
authors.forename: Norio
authors.initials: N
authors.lastname: Asou
authors.forename: Miki
authors.initials: M
authors.lastname: Nakamura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Koh
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tajiri
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Matsuno
authors.forename: Kentaro
authors.initials: K
authors.lastname: Horikawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yonemura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Mitsuya
mesh_terms: D000208:Acute Disease; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002368:Castor Oil / Q000009:adverse effects* / Q000031:analogs & derivatives*; D003561:Cytarabine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D008875:Middle Aged; D013501:Surface-Active Agents / Q000009:adverse effects*; D014581:Urticaria / Q000139:chemically induced; D014815:Vitamins / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D013501:Surface-Active Agents; D014815:Vitamins; D003561:Cytarabine; C023040:polyethoxylated castor oil; D002368:Castor Oil; C015019:enocitabine