title: Correlation between increased platelet-associated IgG and thrombocytopenia in secondary dengue virus infections.
abstract: Although the public health impact of dengue is increasing rapidly, the mechanism of thrombocytopenia in this disease remains unknown. To elucidate this mechanism, the relationship between platelet-associated IgG (PAIgG) and platelet count in 53 patients in the acute phase of secondary dengue virus infection was investigated in a prospective-hospital-based study. A significant inverse correlation between the two parameters was found in these patients, while no correlation was observed in healthy volunteers. The low baseline platelet counts during the acute phase in 12 patients with secondary dengue virus infection significantly increased during the convalescent phase, while the increased PAIgG levels during the acute phase in these patients significantly decreased during the convalescent phase. Anti-platelet IgG autoantibody was detected rarely in the plasma of 53 patients with secondary dengue infection. The involvement of anti-dengue virus IgG was also shown in platelets from all of 8 patients in the acute phase of secondary dengue virus infection. These findings suggest that PAIgG formation involving anti-dengue virus IgG plays a pivotal role in the induction of transient thrombocytopenia during the acute phase of secondary dengue virus infection.
authors.affiliation: Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan. oishi-k@net.nagasaki-u.ac.jp
authors.forename: Kazunori
authors.initials: K
authors.lastname: Oishi
authors.forename: Shingo
authors.initials: S
authors.lastname: Inoue
authors.forename: Maria T D D
authors.initials: MT
authors.lastname: Cinco
authors.forename: Efren M
authors.initials: EM
authors.lastname: Dimaano
authors.forename: Maria T P
authors.initials: MT
authors.lastname: Alera
authors.forename: Jhoe A R
authors.initials: JA
authors.lastname: Alfon
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Abanes
authors.forename: Deu J M
authors.initials: DJ
authors.lastname: Cruz
authors.forename: Ronald R
authors.initials: RR
authors.lastname: Matias
authors.forename: Hiromi
authors.initials: H
authors.lastname: Matsuura
authors.forename: Futoshi
authors.initials: F
authors.lastname: Hasebe
authors.forename: Susumu
authors.initials: S
authors.lastname: Tanimura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kumatori
authors.forename: Kouichi
authors.initials: K
authors.lastname: Morita
authors.forename: Filipinas F
authors.initials: FF
authors.lastname: Natividad
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nagatake
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology*; D002648:Child; D003715:Dengue / Q000150:complications*; D003716:Dengue Virus / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D008297:Male; D010976:Platelet Count; D013921:Thrombocytopenia / Q000209:etiology*
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G