[Expression of monocyte chemoattractant protein-1 in aorta of early hypertensive rats].
OBJECTIVE
To investigate the expression of monocyte chemoattractant protein-1(MCP-1) of aorta wall in acute phase of hypertension in rats with 2 kidney and 1 clip(2K1C).


METHODS
The MCP-1 mRNA on aorta wall was detected by in situ hybridization and reverse transcription-polymerase chain reaction(RT-PCR).


RESULTS
No MCP-1 was expressed in normal rat, but it was expressed on the aorta wall of rats in 1 week after 2K1C hypertensive model was formed. The expression of MCP-1 increased with the development of hypertension.


CONCLUSIONS
The expression of MCP-1 on aorta wall of 2K1C hypertensive rats increases in the early stage of hypertension, which may play an important role in accelerating atherosclerosis.
Xie
Qi-ying
QY
Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410078, China.
Sun
Ming
M
Yang
Tian-lun
TL
D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001161:Arteriosclerosis / Q000209:etiology; D018932:Chemokine CCL2 / Q000096:biosynthesis* / Q000235:genetics; D006973:Hypertension / Q000150:complications / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar
D018932:Chemokine CCL2; D012333:RNA, Messenger