Newer substituted benzoxazepinyl-quinazolinones as potent antipsychotic and anticonvulsant agents.
3-Amino-[2'-substitutedaryl-3'-substitutedarylaminomethylene-2',3'- dihydro-1',5'-benzoxazepin-4'-yl]-2-methyl-quinazolin-4(3H)-ones 11-18 and 3-amino-[2'-substituted aryl-3'-substitutedaryl-azo-2',3'- dihydro-1',5'-benzoxazepin-4'-yl]-2-methyl-quinazolin-4(3H)-ones 19-26 were synthesized from 3-amino-[2'-substitutedaryl-2',3'-dihydro-1',5'- benzoxazepin-4'-yl]-2-methyl-quinazolin-4(3H)-ones 7-10 by Mannich's reaction and by diazotisation, respectively, on the 3rd position of the benzoxazepine ring of the compounds 7-10. The newly synthesized compounds showed potent antipsychotic and anticonvulsant activities.
Bajaj
Kiran
K
Medicinal Chemistry Division, Department of Pharmacology, Lala Lajpat Rai Memorial Medical College, Meerut, U.P., India.
Srivastava
Virendra Kishor
VK
Kumar
Ashok
A
D000661:Amphetamine / Q000037:antagonists & inhibitors; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D002375:Catalepsy / Q000139:chemically induced; D000697:Central Nervous System Stimulants / Q000037:antagonists & inhibitors; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002746:Chlorpromazine / Q000494:pharmacology; D004597:Electroshock; D005260:Female; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis / Q000494:pharmacology; D007202:Indicators and Reagents; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010077:Oxazepines / Q000737:chemistry* / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology; D011799:Quinazolines / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D006993:Hypnotics and Sedatives; D007202:Indicators and Reagents; D010077:Oxazepines; D011799:Quinazolines; D000661:Amphetamine; D010424:Pentobarbital; D002746:Chlorpromazine