[Renal protective effect of nilestriol in aged women with hypertension].
OBJECTIVE
To investigate the renal protective effect of nilestriol in aged hypertensive women.


METHODS
Forty-one aged hypertensive women treated with antihypertensive drugs were randomly divided into two groups. The women in Group A (n = 21) received nilestriol, whereas those in Group B (n = 20) received a placebo for six months. Antihypertensive drugs were unchanged. Twenty-four healthy subjects were set as the normal control group.


RESULTS
1. Before the treatment, the levels of urinary transferrin (TRF), retinol binding protein (RBP), P-selectin, vWF, and ET-1 were significantly higher in the aged hypertensive women than those in the control group. 2. The levels of TRF and RBP significantly decreased in both Group A and Group B after the 6-month treatment, but these levels in Group A were significantly lower than those in Group B (P < 0.05). 3. The levels of P-selectin, vWF, and ET-1 in Group A were significantly lower than those in Group B (P < 0.05-0.01) after the treatment.


CONCLUSIONS
1. In aged hypertensive women treated with antihypertensive drugs, the renal function is still damaged; 2. Nilestriol can significantly decrease the levels of TRF and RBP; 3. The renal protective effect of nilestriol may be related to the protection of endothelin function and antithrombosis activity.
Yang
Kan
K
Department of Cardiology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Pan
Hong-wei
HW
Jiang
Wei-hong
WH
D000368:Aged; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007674:Kidney Diseases / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000652:urine; D017698:Postmenopause; D011800:Quinestrol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D012177:Retinol-Binding Proteins / Q000652:urine; D014168:Transferrin / Q000652:urine
D019007:P-Selectin; D012177:Retinol-Binding Proteins; D014168:Transferrin; C010722:nylestriol; D011800:Quinestrol