[Determination of enantiomeric purity of (S)-(-)-alpha-phenylethylamine by NMR].
It was reported the determination of enantiomeric purities of (S)-(-)-alpha-phenylethylamine by 1H NMR, using (2R, 3R)-dibenzoyl-tartaric acid as chiral solvating agent. 1H NMR chemical shift non-equivalence of the methyl doublet of alpha-phenylethylamine was 0.08 ppm(base-line separation) in solvent CDCl3, when the concentration of the sample was 0.051 mol.L-1, the molar ratio between chiral solvating agent and the sample was 0.33. The enantiomeric purities could be determined by the peak areas of the methyl doublet of alpha-phenylethylamine. The relative standard deviation depended upon the enantiomeric purities of sample. With enantiomeric purities as high as 99.1% ee, the RSD was 0.3% (n = 4).
Jiang
X
X
Petrochemical Institute, ECUST, 201512 Shanghai.
Su
K
K
Cai
S
S
D009682:Magnetic Resonance Spectroscopy; D010627:Phenethylamines / Q000737:chemistry* / Q000302:isolation & purification*; D012997:Solvents; D013237:Stereoisomerism
D010627:Phenethylamines; D012997:Solvents; C033198:1-phenethylamine