Synthesis and structural study of two new heparin-like hexasaccharides.
Two new heparin-like hexasaccharides, 5 and 6, have been synthesised using a convergent block strategy and their solution conformations have been determined by NMR spectroscopy and molecular modelling. Both hexasaccharides contain the basic structural motif of the regular region of heparin but with negative charge distributions which have been designed to get insight into the mechanism of fibroblast growth factors (FGFs) activation.
Lucas
Ricardo
R
Grupo de Carbohidratos, Instituto de Investigaciones Químicas, CSIC, Américo Vespucio s/n, Isla de la Cartuja, 41092 Sevilla, Spain.
Angulo
Jesús
J
Nieto
Pedro M
PM
Martín-Lomas
Manuel
M
D002240:Carbohydrate Sequence; D006493:Heparin / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment
D009844:Oligosaccharides; D006493:Heparin