title: Comorbidity of parkinsonism and schizophrenia in a patient treated with clozapine.
abstract: Clozapine is the least likely anti-psychotic to induce extrapyramidal symptoms (EPS). We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS. Single photon emission computed tomography (SPECT) revealed a low density of presynaptic dopamine transporters in our patient's brain. A comorbid diagnosis of Parkinson's disease in schizophrenia was confirmed in this way. This helped us to find a proper therapeutic strategy for our patient.
authors.affiliation: Department of Psychiatry, University Hospital, 500 05 Hradec Králové, Czech Republic. urban@fnhk.cz
authors.forename: A
authors.initials: A
authors.lastname: Urban
authors.forename: J
authors.initials: J
authors.lastname: Libiger
authors.forename: L
authors.initials: L
authors.lastname: Hosák
authors.forename: K
authors.initials: K
authors.lastname: Kupka
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging; D003024:Clozapine / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000175:diagnosis; D020734:Parkinsonian Disorders / Q000150:complications* / Q000000981:diagnostic imaging / Q000523:psychology; D012008:Recurrence; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine