Basal ganglia and supplementary motor area subtend duration perception: an fMRI study.
Brain imaging studies on duration perception usually report the activation of a network that includes the frontal and mesiofrontal cortex (supplementary motor area, SMA), parietal cortex, and subcortical areas (basal ganglia, thalamus, and cerebellum). To address the question of the specific involvement of these structures in temporal processing, we contrasted two visual discrimination tasks in which the relevant stimulus dimension was either its intensity or its duration. Eleven adults had to indicate (by pressing one of two keys) whether they thought the duration or the intensity of a light (LED) was equal to (right hand) or different from (left hand) that of a previously presented standard. In a control task, subjects had to press one of the two keys at random. A similar broad network was observed in both the duration-minus-control and intensity-minus-control comparisons. The intensity-minus-duration comparison pointed out activation in areas known to participate in cognitive operations on visual stimuli: right occipital gyrus, fusiform gyri, hippocampus, precuneus, and intraparietal sulcus. In contrast, the duration-minus-intensity comparison indicated activation of a complex network that included the basal ganglia, SMA, ventrolateral prefrontal cortex, inferior parietal cortex, and temporal cortex. These structures form several subnetworks, each possibly in charge of specific time-coding operations in humans. The SMA and basal ganglia may be implicated in the time-keeping mechanism, and the frontal-parietal areas may be involved in the attentional and mnemonic operations required for encoding and retrieving duration information.
Ferrandez
A M
AM
Unité de Neurosciences Cognitives et Imagerie Cérébrale, CNRS UPR 640, LENA, Hôpital de la Salpêtrière, 75651 Paris Cedex 13, France. Anne-Marie.Fernandez@chups.jussieu.fr
Hugueville
L
L
Lehéricy
S
S
Poline
J B
JB
Marsault
C
C
Pouthas
V
V
D000328:Adult; D001288:Attention / Q000502:physiology*; D001479:Basal Ganglia / Q000502:physiology*; D001931:Brain Mapping; D002531:Cerebellum / Q000502:physiology; D003118:Color Perception / Q000502:physiology*; D004193:Discrimination Learning / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology; D012016:Reference Values; D013702:Temporal Lobe / Q000502:physiology; D013788:Thalamus / Q000502:physiology; D013998:Time Perception / Q000502:physiology*