Blood-brain barrier changes during invasion of the central nervous system by HIV-1. Old and new insights into the mechanism.
The mechanism underlying the early invasion of the central nervous system by HIV-1 is unclear. Here, we summarize old and new findings supporting blood-brain barrier changes during HIV and experimental simian immunodeficiency virus (SIV) infection. The effect of inflammatory and toxic molecules secreted by monocytes and microglia on the functional integrity of tight junctions of brain endothelium is highlighted. Furthermore, recent findings on a possible direct role of the envelope and regulatory HIV-1 proteins (gp120, Tat, Nef) in causing the blood-brain barrier changes are reviewed. The possibility that these proteins, as circulating molecules, may bind to microvessel endothelial cells and cause blood-brain changes with no direct participation of the virus is raised. Several issues deserve further investigation and answers to these questions may provide keys for new therapeutic strategies in HIV-1 infection of the central nervous system.
Annunziata
Pasquale
P
Dipartimento di Scienze Neurologiche e del Comportamento, Centro per lo Studio della Sclerosi multipla e delle Malattie Neuroimmunologiche, Università di Siena, Viale Bracci, 2, 53100 Siena, Italy. annunziata@unisi.it
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D002493:Central Nervous System Diseases / Q000209:etiology / Q000821:virology*; D004195:Disease Models, Animal; D015696:Gene Products, tat / Q000378:metabolism; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D006801:Humans; D015302:Simian Immunodeficiency Virus / Q000378:metabolism / Q000472:pathogenicity; D054334:Viral Regulatory and Accessory Proteins / Q000378:metabolism; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D015699:HIV Envelope Protein gp120; C429284:NEF protein, SIV; D054334:Viral Regulatory and Accessory Proteins; D054322:tat Gene Products, Human Immunodeficiency Virus