Traceless solid phase synthesis of 2-substituted pyrimidines using an 'off-the-shelf' chlorogermane-functionalised resin.
The parallel solid phase synthesis of an 18-member library of 2-substituted pyrimidines is described using a chlorogermane-functionalised resin. The success of the key Pinner-type condensations between a resin-bound enaminone and an array of amidine hydrochlorides highlights the stability of arylgermane linkers (cf. arylsilanes) towards strongly basic/nucleophilic conditions.
Spivey
Alan C
AC
Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, Yorkshire, UK S3 7HF. a.c.spivey@imperial.ac.uk
Srikaran
Ratnasothy
R
Diaper
Christopher M
CM
Turner
David J
DJ