title: c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis.
abstract: c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II, which is required for the transition from initiation to elongation of eukaryotic transcription. Inhibiting P-TEFb blocks the transcription of its target genes as well as cellular proliferation and apoptosis induced by c-Myc.
authors.affiliation: Departments of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143-0703, USA.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kanazawa
authors.forename: Laura
authors.initials: L
authors.lastname: Soucek
authors.forename: Gerard
authors.initials: G
authors.lastname: Evan
authors.forename: Takashi
authors.initials: T
authors.lastname: Okamoto
authors.forename: B Matija
authors.initials: BM
authors.lastname: Peterlin
mesh_terms: D000818:Animals; D017209:Apoptosis; D019556:COS Cells; D002455:Cell Division; D016259:Genes, myc / Q000502:physiology*; D042925:Positive Transcriptional Elongation Factor B; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D014158:Transcription, Genetic
chemical_list: D042925:Positive Transcriptional Elongation Factor B; D017346:Protein Serine-Threonine Kinases