A form of presynaptic coincidence detection.
In this issue of Neuron, Sjöström et al. provide evidence for a novel presynaptic mechanism for coincidence detection in induction of timing-dependent LTD. In their scheme, simultaneous activation of presynaptic NMDA receptors and CB1 endocannabinoid receptors induces a long-lasting reduction in presynaptic transmitter release.
Froemke
Robert C
RC
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Li
Cheng-yu
CY
Dan
Yang
Y
D000818:Animals; D063385:Cannabinoid Receptor Modulators; D018698:Glutamic Acid / Q000378:metabolism; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D017661:Receptors, Presynaptic / Q000502:physiology*
D063385:Cannabinoid Receptor Modulators; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D016194:Receptors, N-Methyl-D-Aspartate; D017661:Receptors, Presynaptic; D018698:Glutamic Acid