Mycosis fungoides responding to systemic itraconazole.
Mycosis fungoides is a form of cutaneous lymphoma with a typically indolent course. We describe an unexpected, repeated response to a systemic antifungal agent, itraconazole. The mechanism of action is speculative but itraconazole has marked immunosuppressive activity on T-lymphocyte proliferation in vitro.
Cooper
S M
SM
Department of Dermatology, Oxford Radcliffe Hospitals, Oxford OX3 7LJ, UK. sm_nc@btopenworld.com
Sheridan
A
A
Burge
S
S
D000284:Administration, Oral; D001707:Biopsy, Needle; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007150:Immunohistochemistry; D017964:Itraconazole / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D011379:Prognosis; D012720:Severity of Illness Index; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome
D017964:Itraconazole