title: Health effects in community residents near a uranium plant at Fernald, Ohio, USA.
abstract: OBJECTIVE
  Health outcomes in persons who lived in the area surrounding a U.S. Department of Energy (DOE) uranium processing plant near Fernald, Ohio were evaluated using data of Fernald Medical Monitoring Program (FMMP) participants.
  
  
  METHODS
  Residential history information was used to identify participants who lived in close proximity to the plant (less than 2 miles), in the direction of groundwater runoff (south of the plant), or used a well or cistern as a drinking water source. Standardized prevalence ratios (SPRs) for certain disease endpoints were calculated using the U.S. National Health Interview Survey(NHIS) and the National Health and Nutrition Examination Survey (NHANES) data files for comparison rates.
  
  
  RESULTS
  Findings suggest that prior living within the Fernald exposure domain is related to increased prevalence of urinary system disease. Statistically significant elevations of bladder disease (standardized prevalence ratio or SPR = 1.32) and kidney disease (SPR = 2.15), including sub-categories, kidney stones (SPR = 3.98) and chronic nephritis (SPR = 2.03) were noted, as well as increased rates for hematuria and urethral stricture. In regression analyses with adjustment forage and sex, serum creatinine levels were increased in those who had lived close to the plant. Increased white blood cell count and hemoglobin levels, and decreased mean corpuscular volume were also found in those living less than 2 miles from the plant. Those who used a well or cistern for drinking water were found to have increased urinary microalbumin, red blood cell count and hematocrit.
  
  
  CONCLUSIONS
  These preliminary findings will provide the basis for future hypothesis testing incorporating important determinants of exposure not included in this study, such as duration and calendar year of exposure, location relevant to prevailing wind direction, and age at exposure.
authors.affiliation: Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0056, USA. susan.pinney@uc.edu
authors.forename: Susan M
authors.initials: SM
authors.lastname: Pinney
authors.forename: Ronald W
authors.initials: RW
authors.lastname: Freyberg
authors.forename: Gail E
authors.initials: GE
authors.lastname: Levine
authors.forename: Donald E
authors.initials: DE
authors.lastname: Brannen
authors.forename: Lynn S
authors.initials: LS
authors.lastname: Mark
authors.forename: James M
authors.initials: JM
authors.lastname: Nasuta
authors.forename: Colleen D
authors.initials: CD
authors.lastname: Tebbe
authors.forename: Jeanette M
authors.initials: JM
authors.lastname: Buckholz
authors.forename: Robert
authors.initials: R
authors.lastname: Wones
mesh_terms: D000328:Adult; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D004784:Environmental Monitoring; D062665:Epidemiological Monitoring; D005260:Female; D006306:Health Surveys; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D009820:Ohio / Q000453:epidemiology; D015995:Prevalence; D014501:Uranium / Q000097:blood / Q000633:toxicity* / Q000652:urine; D014570:Urologic Diseases / Q000139:chemically induced* / Q000145:classification; D014875:Water Pollutants, Radioactive / Q000633:toxicity*
chemical_list: D014875:Water Pollutants, Radioactive; D014501:Uranium