title: Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance.
abstract: In this paper we show that Clostridium perfringens epsilon-toxin accumulates predominantly in the mouse kidney, where it is distributed mainly in glomeruli, capillaries, and collecting ducts. Although some pycnotic and exfoliated epithelial cells were observed in distal tubuli and collecting ducts, there were no findings indicative of severe renal injury. Bilateral nephrectomy increased the mouse lethality of the toxin, suggesting that the kidney contributes to the host defense against the lethal toxicity of epsilon-toxin.
authors.affiliation: Department of Microbiology, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Kita-gun, Kagawa 761-0793, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Tamai
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ishida
authors.forename: Shigeru
authors.initials: S
authors.lastname: Miyata
authors.forename: Osamu
authors.initials: O
authors.lastname: Matsushita
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Suda
authors.forename: Shoji
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sonobe
authors.forename: Akinobu
authors.initials: A
authors.lastname: Okabe
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000493:pharmacokinetics* / Q000633:toxicity*; D003015:Clostridium Infections / Q000209:etiology / Q000382:microbiology / Q000473:pathology; D003016:Clostridium perfringens / Q000472:pathogenicity*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D009392:Nephrectomy; D011994:Recombinant Proteins / Q000493:pharmacokinetics / Q000633:toxicity; D014018:Tissue Distribution
chemical_list: D001427:Bacterial Toxins; C039811:Clostridium perfringens epsilon-toxin; D011994:Recombinant Proteins