Effects of papillary muscle position on in-vitro dynamic strain on the porcine mitral valve.
OBJECTIVE
Improved knowledge of mitral valve (MV) mechanics is essential to understand normal MV function and design and evaluate new surgical repair procedures. Initially, the dynamic deformation of the central region of the porcine MV anterior leaflet was quantified under simulated physiological conditions to explore the effects of varying papillary muscle (PM) position.


METHODS
Fresh porcine MVs were mounted in an in-vitro physiological flow loop. The PM positions were set to normal, taut, and slack states to simulate physiological and pathological PM positions. Leaflet deformation was measured by tracking the displacement of 16 markers (approximately 250 microm diameter) placed in a 5 x 5 mm section of the central region of the anterior leaflet, approximately 5 mm from the annulus and coaptation line. Local leaflet tissue strain and strain rates were calculated from measured displacements under dynamic loading conditions. A total of 11 mitral valves was studied.


RESULTS
Under the normal PM positional state, the average areal strain rate during valve closure was typically approximately 620% per second. While not measurably altering the maximal areal strain rate, the slack PM position led to a delay in complete valve closure and more rapid leaflet loading (defined as delta transvalvular pressure/delta areal strain) in late systole compared to the other two PM positions.


CONCLUSIONS
It was shown that PM position influenced the MV loading process in the central area of the anterior leaflet. The slack PM position led to a delay in complete valve closure and more rapid leaflet loading in late systole. This increase in loading rate may have long-term consequences in MV function.
He
Zhaoming
Z
Cardiovascular Fluid Mechanics Laboratory, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA 30332-0535, USA.
Sacks
Michael S
MS
Baijens
Lotte
L
Wanant
Sumanas
S
Shah
Parina
P
Yoganathan
Ajit P
AP
D000818:Animals; D001705:Bioprosthesis; D001794:Blood Pressure / Q000502:physiology; D006350:Heart Valve Prosthesis; D008943:Mitral Valve / Q000502:physiology* / Q000637:transplantation*; D023421:Models, Animal; D008955:Models, Cardiovascular; D010210:Papillary Muscles / Q000502:physiology* / Q000601:surgery*; D013552:Swine; D013599:Systole / Q000502:physiology; D013997:Time Factors; D016896:Treatment Outcome