title: Histopathological evaluation of fluorescence bronchoscopy using resected lungs in cases of lung cancer.
abstract: Objective evaluation of the performance of autofluorescence bronchoscopy based on analysis of thin sections of the bronchus of resected lungs was performed and compared with the results of preoperative autofluorescence bronchoscopy. Conventional bronchoscopy and autofluorescence bronchoscopy were performed prior to surgery for lung cancer. Thin sections of the bronchus were obtained from the resected specimens. The thin sections were pathologically analyzed and the diagnostic accuracy of endoscopy was calculated. The subjects were 30 consecutive operable lung cancer cases who received white light and autofluorescence bronchoscopy before operation. A total of 163 thin sections of the bronchi in the resected lungs were made. The sensitivity of white light bronchoscopy for cancer was 90 and 31% for dysplasia. The respective figures for autofluorescence bronchoscopy were 97 and 50% for cancer and dysplasia. The specificity of white light and autofluorescence was 88 and 84%, respectively. The diagnostic accuracy of autofluorescence bronchoscopy was objectively confirmed. Autofluorescence examination showed better sensitivity for cancerous/precancerous lesions and the evaluation of the extent of cancer invasion was accurate.
authors.affiliation: First Department of Surgery, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. ikeda@wd5.so-net.ne.jp
authors.forename: Norihiko
authors.initials: N
authors.lastname: Ikeda
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Hiyoshi
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Kakihana
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Honda
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Kato
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Okunaka
authors.forename: Kinya
authors.initials: K
authors.lastname: Furukawa
authors.forename: Takaaki
authors.initials: T
authors.lastname: Tsuchida
authors.forename: Harubumi
authors.initials: H
authors.lastname: Kato
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Ebihara
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001999:Bronchoscopy / Q000379:methods*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D005453:Fluorescence; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity