FK506-associated limbic injury following umbilical cord blood transplantation.
A 5-year-old girl with Ph-positive chronic myelogenous leukemia, who underwent umbilical cord blood transplantation, developed two episodes of electrical status epilepticus while receiving tacrolimus (FK506) then cyclosporin A (CsA), as treatment against graft-versus-host disease. MRI including diffusion weighted MR imaging of the brain revealed abnormalities in the hippocampus and posterior white matter following FK506 and CsA treatment, respectively. While posterior white matter injury has been described with both FK506 and CsA, no previous report describes hippocampal injury from either drug. The MRI changes in the hippocampus in our case suggest possible increased susceptibility to hippocampal injury with FK506.
Yoshida
Y
Y
Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.
Shimada
H
H
Mori
T
T
Yoshihara
H
H
Takeoka
M
M
Takahashi
T
T
D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D004827:Epilepsy / Q000139:chemically induced*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000628:therapy; D008032:Limbic System / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D016559:Tacrolimus / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D016559:Tacrolimus