[A case of multiple lung metastases of colon cancer with long-term survival following 5'-DFUR and cimetidine therapy].
A 77-year-old woman treated for diabetes mellitus was admitted to our hospital for further examination of abnormal findings on chest plain radiograph. Many nodular shadows in both lung fields were seen on chest X ray and chest CT scan. Colonoscopic examination revealed a type 2 tumor in the ascending colon. We diagnosed this case as ascending colon carcinoma with multiple lung metastases, and performed right hemicolectomy and D1 lymph node dissection. After surgery, the patient was administered 5'-DFUR 600 mg/body/day, cimetidine 800 mg/body/day orally. Though no remarkable reduction of tumors was recognized, the increase of tumor size was relatively slow. The patient remains alive 3 years after surgery.
Fujiwara
Shozo
S
Dept. of Surgery, Nagato Memorial Hospital.
Noguchi
Tsuyoshi
T
Suehiro
Syuji
S
Kikuchi
Ryuichi
R
Noguchi
Takuya
T
Uchida
Yuzo
Y
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D002927:Cimetidine / Q000008:administration & dosage*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D004359:Drug Therapy, Combination; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*
D000276:Adjuvants, Immunologic; D000964:Antimetabolites, Antineoplastic; D006635:Histamine H2 Antagonists; D005467:Floxuridine; D002927:Cimetidine; C025034:doxifluridine