title: [Perioperative management of ventricular assist devices].
abstract: OBJECTIVE
  To review the perioperative anaesthetic management of ventricular assist devices.
  
  
  METHODS
  Extraction from Pubmed database of french and english articles on the perioperative anaesthetic management of ventricular assist devices for 15 years.
  
  
  METHODS
  The collected articles were reviewed and selected according to their quality and originality. The more recent data were selected.
  
  
  RESULTS
  Cardiac transplantation is an effective treatment for patients in end stage cardiac failure, but the average waiting time of 17 months, associated with the lack of organs (357 out of 832 candidates were transplanted in 1996) results in a high number of deaths in patients awaiting transplantation. The appearance in the 1980's, of the first ventricular assist device (VAD) provided a new possibility for the management of patients with end-stage cardiac failure awaiting transplantation ("bridge to transplant"). The perioperative anaesthetic management of these patients is complex. End stage cardiac failure, poorly responsive to pharmacological interventions, results rapidly in secondary organ dysfunctions. VADs produce a rapid improvement in haemodynamic, renal, hepatic and neuro-endocrine functions over a 2 months period, allowing transplantation to take place under optimal conditions. However VADs are not without complications (1 year mortality of 20%), of which the major are: infections (40%), perioperative haemorrhage (30%) and thrombo-embolic sequelae (30%). A best knowledge of pathophysiology of these complications is necessary to an optimal management of patients with ventricular assist devices.
authors.affiliation: Département d'anesthésie-réanimation adulte, CHU La Timone, 126, rue Saint-Pierre, 13385 Marseille 5, France. fkerbaul@yahoo.fr
authors.forename: F
authors.initials: F
authors.lastname: Kerbaul
authors.forename: F
authors.initials: F
authors.lastname: Collart
authors.forename: M
authors.initials: M
authors.lastname: Bonnet
authors.forename: J
authors.initials: J
authors.lastname: Villacorta
authors.forename: C
authors.initials: C
authors.lastname: Guidon
authors.forename: F
authors.initials: F
authors.lastname: Gouin
mesh_terms: D000758:Anesthesia; D002986:Clinical Trials as Topic; D006331:Heart Diseases / Q000601:surgery; D006353:Heart-Assist Devices / Q000009:adverse effects; D006801:Humans; D019990:Perioperative Care; D011182:Postoperative Care; D011300:Preoperative Care; D019919:Prosthesis Implantation / Q000009:adverse effects / Q000401:mortality