[Experimental study of magnetic pingyangmycine-bearing microspheres in the treatment of cavernous hemangioma].
OBJECTIVE
To investigate the probability and mechanism magnetic pingyangmycine-bearing microspheres(MPMs) in the treatment of cavernous hemangioma.


METHODS
Twenty rabbits were divided into four groups. MPMs, pingyangmycine and magnetic nonpingyangmycine-bearing microspheres were injected into marginal ear veins respectively. All animals were killed after 21 days and histological varations of the veins were observed under the light microscope and transmission electron microscope.


RESULTS
The occlusion of the veins in the group of MPMs with the external magnetic field was more prominent than that in the other groups.


CONCLUSIONS
MPMs can occlude veins by means of its embolized effect and PYM drug effect. MPMs may be better used in the therapy of cavernous hemangioma.
Zhang
Sheng
S
Department of Stomatology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Wu
Han-jiang
HJ
Ling
Tian-you
TY
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005260:Female; D006392:Hemangioma, Cavernous / Q000188:drug therapy*; D008280:Magnetics; D008297:Male; D008863:Microspheres; D011817:Rabbits
D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D001761:Bleomycin; C021771:zhengguangmycin