A family of macrocyclic antibiotics with a mixed peptide-peptoid beta-hairpin backbone conformation.
Macrocyclic peptidomimetics having a mixed peptide-peptoid backbone have been synthesized and shown to possess antibiotic activity against gram-positive and -negative bacteria with a low hemolytic activity against human erythrocytes; one is shown to adopt a regular beta-hairpin conformation by NMR in aqueous solution.
Shankaramma
Sasalu C
SC
Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Moehle
Kerstin
K
James
Sonya
S
Vrijbloed
Jan W
JW
Obrecht
Daniel
D
Robinson
John A
JA
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D006860:Hydrogen Bonding; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D011487:Protein Conformation; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic