Pitfalls of toxicological analysis.
Pitfalls are a permanent risk in all fields of forensic- and clinical-toxicological analysis and are not only concerned with immunoassays, although they are at present mostly discussed with regard to this subject. There are risks inherent in the field of preanalysis (e.g. the sampling, transportation, storage und treatment of the samples immediately prior to analysis). Furthermore, various pitfalls during measurement itself are to be avoided in connection with derivatization, choice of analysis parameters, memory-effects and many other sources of error. Another important section concerns the pharmacokinetic and pharmacodynamic interpretation of analytical results. Many toxicokinetic (e.g. enzyme induction) and toxicodynamic factors (e.g. tolerance effects) must be considered with special regard to plausibility controls (e.g. constellation, longitudinal, transversal and trend monitoring).
Schütz
Harald
H
Institute of Legal Medicine, University Giessen, Frankfurter Str. 58, D-35392 Giessen, Germany. harald.f.schuetz@forens.med.uni-giessen.de
Erdmann
Freidoon
F
Verhoff
Marcel A
MA
Weiler
Günter
G
D005188:False Negative Reactions; D005189:False Positive Reactions; D005554:Forensic Medicine / Q000379:methods*; D006801:Humans; D010599:Pharmacokinetics; D010600:Pharmacology; D014116:Toxicology / Q000379:methods*