Does the DABCO-catalysed reaction of 2-hydroxybenzaldehydes with methyl acrylate follow a Baylis-Hillman pathway?
Evidence is presented which supports the intermediacy of dipolar Baylis-Hillman-type adducts in the synthesis of coumarin and chromene derivatives from the reaction of 2-hydroxybenzaldehydes with methyl acrylate in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO).
Kaye
Perry T
PT
Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa. P.Kaye@ru.ac.za
Musa
Musiliyu A
MA
Nocanda
Xolani W
XW
Robinson
Ross S
RS