title: Delta-opioid receptor agonists as a therapeutic approach in Parkinson's disease.
abstract: Current symptomatic treatments for Parkinson's disease are based largely on dopamine replacement therapies; however, the fact that these treatments are characterized by many long-term side effects has led to widespread interest in nondopaminergic therapies. To date, a nondopaminergic therapy with comparable efficacy to dopamine replacement has not been devised. Here the authors discuss recent findings that systemic administration of a selective delta-opioid receptor agonist has powerful antiparkinsonian effects in rodent and primate models of Parkinson's disease that are equivalent to those of dopamine replacement. delta-Opioid receptor agonists may prove to be useful for the symptomatic treatment of Parkinson's disease in humans.
authors.affiliation: Motac Neuroscience Ltd., Incubator Building, Grafton St., Manchester, UK.
authors.forename: M P
authors.initials: MP
authors.lastname: Hill
authors.forename: C J
authors.initials: CJ
authors.lastname: Hille
authors.forename: J M
authors.initials: JM
authors.lastname: Brotchie