New perspectives on mitochondrial morphology in cell function.
Mitochondria are a node of integration for intracellular signaling pathways and their morphology changes seem to be tightly associated with their function. New data show that morphology is one of the parameters involved in mitochondria's choice between promoting cell death and protecting cells against general metabolic jeopardy.
Brocard
Jacques B
JB
Department of Pharmacology, School of Medicine, University of Pittsburgh, PA 15261, Pittsburgh, USA. jbrocard@cea.fr
Rintoul
Gordon L
GL
Reynolds
Ian J
IJ
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D005057:Eukaryotic Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008561:Membrane Fusion / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D008928:Mitochondria / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure; D024101:Mitochondrial Proteins / Q000235:genetics / Q000502:physiology; D008933:Mitochondrial Swelling / Q000502:physiology
D024101:Mitochondrial Proteins