title: Non-steroidal anti-inflammatory drug use is associated with reduction in recurrence of advanced and non-advanced colorectal adenomas (United States).
abstract: OBJECTIVE
  To prospectively examine the association between non-steroidal anti-inflammatory drugs (NSAIDs) use (including dose and dosage schedule) and the recurrence of colorectal adenomas among individuals who were diagnosed with an adenoma at entry into a clinical trial.
  
  
  METHODS
  For this analysis, participants who completed the full follow-up (n = 1905) for the Polyp Prevention Trial (PPT) were evaluated. Information on current use and dose of NSAIDs and other drugs was obtained at baseline and at each subsequent study visit over the duration of the trial. The study endpoint was the recurrence of colorectal adenomas in the 3 years between the 1-year trial colonoscopy (T1) and the end of the trial colonoscopy (T4).
  
  
  RESULTS
  There was a significant reduction in overall adenoma recurrence among NSAIDs users (odds ratio [OR] = 0.77; 95% confidence interval [CI]: 0.63-0.95), with the greatest effect seen in advanced polyps (OR = 0.51; CI: 0.33-0.79). Among aspirin users, we observed a significant dose response for overall adenoma recurrence, with a 40% reduction in the OR association (OR = 0.56; 95% CI: 0.31-0.99) among those taking more than 325 mg per day.
  
  
  CONCLUSIONS
  This prospective study provides further evidence that NSAIDs may play an important role in the chemoprevention of recurrent colorectal adenomas, even those with advanced features.
authors.affiliation: Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-7058, USA. jt48w@nih.gov
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Tangrea
authors.forename: Paul S
authors.initials: PS
authors.lastname: Albert
authors.forename: Elaine
authors.initials: E
authors.lastname: Lanza
authors.forename: Karen
authors.initials: K
authors.lastname: Woodson
authors.forename: Don
authors.initials: D
authors.lastname: Corle
authors.forename: Marsha
authors.initials: M
authors.lastname: Hasson
authors.forename: Randall
authors.initials: R
authors.lastname: Burt
authors.forename: Bette
authors.initials: B
authors.lastname: Caan
authors.forename: Electra
authors.initials: E
authors.lastname: Paskett
authors.forename: Frank
authors.initials: F
authors.lastname: Iber
authors.forename: J Walter
authors.initials: JW
authors.lastname: Kikendall
authors.forename: Peter
authors.initials: P
authors.lastname: Lance
authors.forename: Moshe
authors.initials: M
authors.lastname: Shike
authors.forename: Joel
authors.initials: J
authors.lastname: Weissfeld
authors.forename: Arthur
authors.initials: A
authors.lastname: Schatzkin
mesh_terms: D000236:Adenoma / Q000453:epidemiology / Q000517:prevention & control*; D018256:Adenomatous Polyps; D000368:Aged; D000704:Analysis of Variance; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000517:prevention & control*; D016017:Odds Ratio; D011446:Prospective Studies; D014481:United States / Q000453:epidemiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin