[A preliminary study on the relationship between TF-1 cell apoptosis-related gene 19 and thyroid tumor].
OBJECTIVE
To investigate whether TF-1 cell apoptosis-related gene 19 (TFAR19), a novel apoptosis-related protein, is expressed in the tissue of thyroid adenoma (TA) or papillary thyroid carcinoma (PTC) and the cellular location of the expression.


METHODS
Thyroid tumor tissue specimens were obtained from six patients with TA and six patients with PTC by surgical biopsies for pathological diagnosis. Normal peri-tumor thyroid tissue from the six TA patients served as control. Immunohistochemical staining was used to detect TFAR19 expression.


RESULTS
TFAR19 expression was barely detectable in normal thyroid tissue. However, TFAR19 expression was strongly positive in the thyroid tumor tissue of TA group but negative in that of PTC group.


CONCLUSIONS
Our preliminary data have demonstrated for the first time that TFAR19-related apoptotic pathway is activated in the tumor cells of TA and inhibited in those of PTC. The imbalance between cell apoptosis and proliferation might have an important role in the pathogenesis of PTC.
Du
Ying
Y
Department of Endocrinology, Peking University Third Hospital, Beijing 100083, China.
Hong
Tian-pei
TP
D000236:Adenoma / Q000378:metabolism / Q000473:pathology; D000328:Adult; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000473:pathology; D002455:Cell Division; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology
D051017:Apoptosis Regulatory Proteins; D009363:Neoplasm Proteins; C117283:PDCD5 protein, human