title: Management of infection in the surgical patient: an update.
abstract: Management of severe surgical infections remains difficult and requires a multifaceted approach. In this review, we briefly summarise our approach to surgical infection, concentrating on the underlying pathological processes of intraabdominal infection. Two promising new therapies--activated protein C (ACP) and stress-dose hydrocortisone--are reviewed as adjunctive management in treatment of patients with septic shock.
authors.affiliation: Department of Surgery, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Ian D
authors.initials: ID
authors.lastname: McGilvray
authors.forename: Ori D
authors.initials: OD
authors.lastname: Rotstein
mesh_terms: D000900:Anti-Bacterial Agents; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D007813:Laparotomy / Q000009:adverse effects* / Q000379:methods; D008297:Male; D010538:Peritonitis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D011183:Postoperative Complications / Q000175:diagnosis / Q000628:therapy; D011379:Prognosis; D011486:Protein C / Q000627:therapeutic use*; D018570:Risk Assessment; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D013514:Surgical Procedures, Operative / Q000009:adverse effects / Q000379:methods; D013530:Surgical Wound Infection / Q000175:diagnosis / Q000628:therapy; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D011486:Protein C; D006854:Hydrocortisone