title: Panniculitis secondary to extravasation of clarithromycin in a patient with alpha 1-antitrypsin deficiency (phenotype PiZ).
abstract: alpha 1-Antitrypsin deficiency (AATD) is known to be associated with panniculitis. Although reports of this association are rare, the true incidence may be unappreciated because of underdiagnosis of AATD. We report a case of panniculitis occurring in a 34-year-old woman with severe AATD following the extravasation of clarithromycin infused intravenously for treatment of community-acquired pneumonia. Resolution occurred with conservative management. The histopathology and management of this unusual condition are discussed, with a review of the literature.
authors.affiliation: Department of Pulmonology, University Hospital Birmingham, Birmingham, UK.
authors.forename: D G
authors.initials: DG
authors.lastname: Parr
authors.forename: D G
authors.initials: DG
authors.lastname: Stewart
authors.forename: I
authors.initials: I
authors.lastname: Hero
authors.forename: R A
authors.initials: RA
authors.lastname: Stockley
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D017291:Clarithromycin / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000150:complications; D005260:Female; D005542:Forearm / Q000473:pathology; D006801:Humans; D015434:Panniculitis / Q000139:chemically induced*; D019896:alpha 1-Antitrypsin Deficiency / Q000150:complications*
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin