[Cytogenetic abnormalities in acute lymphoblastic leukemia].
Acute lymphoblastic leukemias (ALL) represent malignant clonal proliferations of stem cells committed in lymphoid differentiation, B or T-cell ALL. Clonal chromosomal abnormalities are found in 80% children and 70% adult cases. They are associated with an independent prognostic value which modifies the therapeutic approach and therefore karyotyping at diagnosis is mandatory. Molecular techniques such as FISH and RT-PCR are very helpful too as cryptic chromosomal abnormalities have been described. In this review, numerical and structural abnormalities are described: frequency, diagnosis and prognosis value as well as genes involved in structural abnormalities.
Lafage-Pochitaloff
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M
Département de biopathologie, Institut Paoli-Calmettes, 232, boulevard Sainte-Marguerite, 13009 Marseille, Inserm U119 et Université de la Méditerranée, France. lafagem@marseille.fnclcc.fr
Charrin
C
C
D001402:B-Lymphocytes; D002869:Chromosome Aberrations; D002999:Clone Cells; D003582:Cytogenetics; D006801:Humans; D007621:Karyotyping; D011003:Ploidies; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011379:Prognosis; D013601:T-Lymphocytes; D014178:Translocation, Genetic