Humoral responses to defined malaria antigens in children living since birth under insecticide treated curtains in Burkina Faso.
Insecticide treated materials (ITM) are considered a useful malaria control measure for endemic countries, but whether they also delay the acquisition of immunity to malaria remains unclear. This study investigates plasma antibody levels in 160 children aged 3-6 years from five villages protected by insecticide treated curtains (ITC) over 6 years and in 184 children of the same age group from five villages in the same area never covered by ITC. The antigens to which antibodies were investigated were: the Plasmodium falciparum circumsporozoite protein (CSP) repetitive sequence (NANP)5; the C-terminal domain of the P. falciparum exported protein 1 (Cter-PfExp1); three fragments of the glutamate rich protein (GLURP), referred to as R0, R1 and R2; the merozoite surface protein 3 (MSP3). The level of antibodies was lower in children from the ITC area than in children from the non-ITC area for (NANP)5, R0, R2 and MSP3. Prevalence and intensity of P. falciparum infection were similar in the two groups of children. These findings suggest that reducing the level of malaria transmission over a long period may affect the level of antibodies in children to both sporozoite and blood stage malaria antigens.
Nébié
Issa
I
Centre National de Recherche et de Formation sur le Paludisme, 01 BP 2208 Ouagadougou 01, Burkina Faso. issanebie.cnlp@fasonet.bf
Cuzin-Ouattara
N
N
Diallo
D A
DA
Cousens
S N
SN
Theisen
M
M
Corradin
G
G
Traoré
A S
AS
Esposito
F
F
D000818:Animals; D000917:Antibody Formation; D000953:Antigens, Protozoan / Q000097:blood*; D002050:Burkina Faso / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control; D008297:Male; D009032:Mosquito Control; D010963:Plasmodium falciparum / Q000276:immunology*; D015995:Prevalence
D000953:Antigens, Protozoan