title: Eruptive xanthomas associated with olanzapine use.
abstract: BACKGROUND
  Since their introduction to the US market, atypical antipsychotic drugs, such as olanzapine, have been widely prescribed for the management of psychosis and have increasingly been used in dermatologic settings for the treatment of psychogenic dermatoses. Mild hyperglycemia and hypertriglyceridemia have been documented from the use of these medications, but the range of effects on metabolism and the effects on skin are poorly characterized. OBSERVETION: We describe 3 patients who developed eruptive xanthomas, 1 of whom had relative insulin insufficiency, after starting olanzapine therapy. These cases further support the association of severe dyslipidemia with olanzapine use in selected patients.
  
  
  CONCLUSIONS
  With the increasing use of atypical antipsychotic agents in the dermatologic setting, the dyslipidemia that develops in association with olanzapine use emphasizes the need for periodic metabolic studies in high-risk patients.
authors.affiliation: Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, Calif. 94305, USA.
authors.forename: Howard Y
authors.initials: HY
authors.lastname: Chang
authors.forename: Todd W
authors.initials: TW
authors.lastname: Ridky
authors.forename: Alexandra B
authors.initials: AB
authors.lastname: Kimball
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Hughes
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Oro
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001569:Benzodiazepines; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D010890:Pirenzepine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D014973:Xanthomatosis / Q000139:chemically induced* / Q000473:pathology
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine