title: Influence of creatine monohydrate ingestion on muscle metabolites and intense exercise capacity in individuals with multiple sclerosis.
abstract: OBJECTIVE
  To evaluate the effectiveness of ingesting creatine monohydrate in elevating intramuscular creatine stores and improving exercise capacity in individuals with multiple sclerosis (MS).
  
  
  METHODS
  Randomized, double-blind, placebo-controlled, pre-posttrial.
  
  
  METHODS
  A university-based exercise physiology laboratory.
  
  
  METHODS
  Sixteen individuals with relapsing-remitting MS (median Expanded Disability Status Scale score, 4.75; range, 1.5-6.0).
  
  
  METHODS
  Eight individuals with MS were randomized to the creatine group (20g/d of creatine monohydrate for 5d), and 8 others were randomized to the placebo group. Needle biopsies were performed on the vastus lateralis at rest before and after treatment. Subjects performed 3 bouts of 30 maximal knee extensions and flexions at 180 degrees /s with 1 minute of recovery between bouts before and after treatment.
  
  
  METHODS
  Intramuscular total creatine, phosphocreatine, free creatine, and total work output.
  
  
  RESULTS
  Creatine ingestion did not significantly elevate intramuscular total creatine, phosphocreatine, or free creatine or improve total work production.
  
  
  CONCLUSIONS
  Creatine ingestion had no significant effect on muscle creatine stores or high-intensity exercise capacity in individuals with MS.
authors.affiliation: Nutrition, Metabolism, and Exercise Laboratory, Donald W. Reynolds Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA. LamberCharlesP@uams.edu
authors.forename: Charles P
authors.initials: CP
authors.lastname: Lambert
authors.forename: R Lee
authors.initials: RL
authors.lastname: Archer
authors.forename: John A
authors.initials: JA
authors.lastname: Carrithers
authors.forename: William J
authors.initials: WJ
authors.lastname: Fink
authors.forename: William J
authors.initials: WJ
authors.lastname: Evans
authors.forename: Todd A
authors.initials: TA
authors.lastname: Trappe
mesh_terms: D000328:Adult; D001707:Biopsy, Needle / Q000379:methods; D003401:Creatine / Q000008:administration & dosage*; D004185:Disability Evaluation; D004311:Double-Blind Method; D016552:Ergometry / Q000379:methods; D015444:Exercise / Q000502:physiology; D017079:Exercise Tolerance / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000378:metabolism*; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000378:metabolism*; D010725:Phosphocreatine / Q000032:analysis; D015990:Placebo Effect; D016896:Treatment Outcome
chemical_list: D010725:Phosphocreatine; D003401:Creatine