Can't learn without you: predictive value coding in orbitofrontal cortex requires the basolateral amygdala.
Basolateral amygdala and orbitofrontal cortex are implicated in cue-outcome learning. In this issue of Neuron, Schoenbaum et al. show that, following basolateral amygdala lesions, cue-selective neurons in orbitofrontal cortex are more sensory driven and less sensitive to the motivational value of an outcome, suggesting that predictive value coding in orbitofrontal cortex is dependent on input from basolateral amygdala.
O'Doherty
John
J
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom.
D000679:Amygdala / Q000166:cytology / Q000502:physiology*; D000818:Animals; D005625:Frontal Lobe / Q000166:cytology / Q000502:physiology*; D007858:Learning / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D012201:Reward