Mechanisms of action of extracorporeal photochemotherapy in the control of GVHD: involvement of dendritic cells.
Despite the fact that extracorporal photochemotherapy (ECP) is now broadly used for the treatment of graft versus host disease or T-cell lymphomas, the mechanisms of its action remain enigmatic. This work provides a synthesis of the main results suggesting the initiation by ECP of an immune reaction responsible for the down modulation of pathogenic T-cell functions, with a special focus on the role of dendritic cells in this phenomenon.
Plumas
J
J
Department of Research and Development and Cell Therapy Unit, EFS Rhône-Alpes, CHU Michalon, UJF, Grenoble, France.
Manches
O
O
Chaperot
L
L
D015703:Antigens, CD / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006086:Graft vs Host Disease / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D017893:Photopheresis; D033581:Stem Cell Transplantation; D014184:Transplantation, Homologous / Q000276:immunology
D015703:Antigens, CD