title: Activity of daptomycin against recent North American isolates of Streptococcus pneumoniae.
abstract: Daptomycin MICs at which 50% of isolates were inhibited (MIC(50)s) and MIC(90)s determined by the NCCLS broth microdilution method were both 0.25 microg/ml (range, 0.06 to 2 microg/ml) for 350 pneumococcal isolates. MICs determined by E test strips on commercially prepared Mueller-Hinton sheep blood agars with different calcium contents were 2 to 3 dilutions higher than those determined by strips that contained daptomycin plus calcium. Daptomycin zone diameters varied little on the same media.
authors.affiliation: Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA.
authors.forename: M I
authors.initials: MI
authors.lastname: Restrepo
authors.forename: J A
authors.initials: JA
authors.lastname: Velez
authors.forename: M L
authors.initials: ML
authors.lastname: McElmeel
authors.forename: C G
authors.initials: CG
authors.lastname: Whitney
authors.forename: J H
authors.initials: JH
authors.lastname: Jorgensen
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D003470:Culture Media; D017576:Daptomycin / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009656:North America; D011008:Pneumococcal Infections / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D017576:Daptomycin; D002118:Calcium