title: Influence of human T lymphotrophic virus type I on cryptogenic fibrosing alveolitis - HTLV-I associated fibrosing alveolitis: proposal of a new clinical entity.
abstract: Human T lymphotrophic virus type-I (HTLV-I), a human retrovirus, infects CD4+ lymphocytes and is thought to modify their function; a possible association with pulmonary diseases has also been suggested. However, little is known about the influence of HTLV-I on cryptogenic fibrosing alveolitis (CFA), a chronic inflammatory interstitial lung disease of unknown aetiology. In order to clarify the influence of HTLV-I infection on CFA, 72 CFA patients with and without HTLV-I infection were examined. HTLV-I positive CFA patients were likely to have larger affected areas and to show traction bronchiectasis with honeycombing change. An imbalance of matrix metalloproteinases and tissue inhibitor of metalloproteinases were also observed in the BALF of HTLV-I positive CFA patients. CD3+/CD25+ lymphocyte percentage was significantly higher in the BALF of HTLV-I positive patients compared to negative patients. MIP-1alpha, IP-10 and sICAM levels in BALF were also significantly higher in HTLV-I positive patients than in negative patients. The levels of MCP-1 and IL-8 were not significantly different. In HTLV-I positive patients, the MIP-1alpha and IP-10 levels showed a significant positive correlation with percentage of CD3+/CD25 lymphocytes. HTLV-I positive CFA patients showed a larger lesion than negative patients and exhibited increased levels of certain cytokines that correlated with activated T cells in the BALF. We suggest that HTLV-I infection may contribute to the development of CFA via activation of T cells. We also propose that these features should be taken into consideration in the treatment of CFA in HTLV-I infected individuals.
authors.affiliation: Third Department of Internal Medicine, Kagoshima University Faculty of Medicine, Kagoshima, Japan. vega@xa2.so-net.ne.jp
authors.forename: W
authors.initials: W
authors.lastname: Matsuyama
authors.forename: M
authors.initials: M
authors.lastname: Kawabata
authors.forename: A
authors.initials: A
authors.lastname: Mizoguchi
authors.forename: F
authors.initials: F
authors.lastname: Iwami
authors.forename: J
authors.initials: J
authors.lastname: Wakimoto
authors.forename: M
authors.initials: M
authors.lastname: Osame
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D017252:CD3 Complex / Q000032:analysis; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000032:analysis; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D054357:Chemokine CXCL10; D016009:Chi-Square Distribution; D015481:HTLV-I Antibodies / Q000097:blood; D015490:HTLV-I Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology; D015368:Human T-lymphotropic virus 1; D006801:Humans; D008168:Lung / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D019402:Macrophage Inflammatory Proteins / Q000032:analysis; D020782:Matrix Metalloproteinases / Q000032:analysis; D008875:Middle Aged; D015995:Prevalence; D011658:Pulmonary Fibrosis / Q000276:immunology / Q000473:pathology / Q000821:virology*; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000276:immunology; D019714:Tissue Inhibitor of Metalloproteinases / Q000032:analysis
chemical_list: D017252:CD3 Complex; D015815:Cell Adhesion Molecules; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D054357:Chemokine CXCL10; D015481:HTLV-I Antibodies; D019402:Macrophage Inflammatory Proteins; D015375:Receptors, Interleukin-2; D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases