title: Primary CD30/Ki-1 positive anaplastic large cell lymphoma of the central nervous system occurring in a patient with a seventeen-year history of essential thrombocythemia.
abstract: We present a rare case of central nervous system lymphoma that occurred in a patient who had essential thrombocythemia for 17 years. MRI examinations disclosed multiple ring-enhanced lesions that had shown bilateral spreading in the different period. Pathological examinations confirmed CD30/Ki-1-positive ALK negative anaplastic large cell lymphoma. The possible pathogenic mechanisms of this disease are discussed.
authors.affiliation: Department of Neurology, Sapporo City General Hospital, N 11, W13, Chu-o-ku, Sapporo, 060-8604, Japan. fwkc2023@mb.infoweb.ne.jp
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Tajima
authors.forename: Yusei
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Takuya
authors.initials: T
authors.lastname: Higashi
authors.forename: Ri-Ichiro
authors.initials: R
authors.lastname: Kishimoto
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Sudoh
authors.forename: Akihisa
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Seiji
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Kunio
authors.initials: K
authors.lastname: Tashiro
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000378:metabolism; D017728:Lymphoma, Large-Cell, Anaplastic / Q000378:metabolism / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011379:Prognosis; D013920:Thrombocythemia, Essential / Q000150:complications*
chemical_list: D017730:Ki-1 Antigen