title: Wiring the olfactory bulb--activity-dependent models of axonal targeting in the developing olfactory pathway.
abstract: Two recent experimental studies /20,21/ revealed that odorant-evoked activity-dependent competition is significant in the organisation and maintenance of the olfactory system. In this paper, we investigate the generation of a chemotopic sensory map in the olfactory bulb through three models driven by high-density optical chemosensor arrays which have similar properties to olfactory receptor neurons. By exposing the sensor arrays to various odours, these models were subjected to Hebbian learning to achieve self-organisation, potentially explaining the activity-dependent competition demonstrated by these recent studies. Our final model also predicts a role for periglomerular cells in the formation of the chemotopic sensory map in the olfactory bulb.
authors.affiliation: Department of Engineering, University of Leicester, Leicester, UK.
authors.forename: Daljeet S
authors.initials: DS
authors.lastname: Gill
authors.forename: Tim C
authors.initials: TC
authors.lastname: Pearce
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D001931:Brain Mapping; D016000:Cluster Analysis; D003198:Computer Simulation; D005071:Evoked Potentials / Q000502:physiology*; D051379:Mice; D008959:Models, Neurological; D009473:Neuronal Plasticity; D009812:Odorants; D009830:Olfactory Bulb / Q000502:physiology*; D009833:Olfactory Pathways / Q000166:cytology / Q000254:growth & development* / Q000502:physiology; D018034:Olfactory Receptor Neurons / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D018035:Receptors, Odorant / Q000502:physiology; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology
chemical_list: D018035:Receptors, Odorant