5-Formyl-2-furylboronic acid as a versatile bifunctional reagent for the synthesis of pi-extended heteroarylfuran systems.
5-Formyl-2-furylboronic acid reacts cleanly with a range of heteroaryl bromides under Suzuki-Miyaura cross-coupling conditions to produce 2-formyl-5-heteroarylfuran derivatives. Subsequent Wittig olefination reactions afford pi-conjugated alkene-pyridyl-furan derivatives.
Parry
Paul R
PR
Department of Chemistry, University of Durham, Durham, UK DH1 3LE.
Bryce
Martin R
MR
Tarbit
Brian
B