Tricuspid regurgitation in patients with repaired Tetralogy of Fallot and its relation to right ventricular dilatation.
In a cohort of 56 school-aged children with repaired tetralogy of Fallot, significant (moderate to severe) tricuspid regurgitation was common (32% of patients) and was related to both tricuspid annulus dilatation and structural valve abnormalities that were potentially related to previous surgery. Even after adjusting for pulmonary regurgitation, tricuspid regurgitation was significantly correlated with right ventricular volume (r= 0.39, p = 0.009), suggesting that tricuspid regurgitation as well as pulmonary regurgitation may contribute significantly to progressive right ventricular dilatation in this population.
Mahle
William T
WT
Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia 30329, USA. wmahle@emory.edu
Parks
W James
WJ
Fyfe
Derek A
DA
Sallee
Denver
D
D002306:Cardiac Volume; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D018618:Echocardiography, Doppler, Color; D005500:Follow-Up Studies; D006801:Humans; D017380:Hypertrophy, Right Ventricular / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D007223:Infant; D008279:Magnetic Resonance Imaging; D011183:Postoperative Complications / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D015995:Prevalence; D011665:Pulmonary Valve Insufficiency / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D012307:Risk Factors; D012720:Severity of Illness Index; D013318:Stroke Volume; D013599:Systole; D013771:Tetralogy of Fallot / Q000150:complications* / Q000601:surgery*; D013997:Time Factors; D014262:Tricuspid Valve Insufficiency / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology