Lead acetate induced cytotoxicity in male germinal cells of Swiss mice.
Single intraperitoneal injection of lead acetate (200 mg/kg b.w) to Swiss mice stimulated testicular weight loss with a constant increase in the incidence of abnormal sperm population and decrease in the total sperm count. Testicular ascorbic acid also declined significantly during the post-treatment phase with significant rise in Lipid Peroxidation Potential (LPP) of the tissue. Elevated LPP is indicative of oxidative stress in treated mice testes. The possible role of lead-induced oxidative stress in culminating increased sperm abnormality and decreased sperm count have been discussed. Further, possible antioxidative role of testicular ascorbic acid in minimizing oxidative stress in lead-treated mice has been demonstrated.
Acharya
U R
UR
Department of Zoology, Berhampur University, Berhampur, 760007, Orissa, India.
Acharya
S
S
Mishra
M
M
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000633:toxicity*; D013076:Sperm Count; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects*; D013737:Testis / Q000187:drug effects / Q000378:metabolism
D009942:Organometallic Compounds; D001205:Ascorbic Acid; C008261:lead acetate