title: The diagnosis and management of pre-invasive breast disease: pathology of atypical lobular hyperplasia and lobular carcinoma in situ.
abstract: The term lobular neoplasia refers to a spectrum of lesions featuring atypical lobular hyperplasia and lobular carcinoma in situ (LCIS). The histopathological characteristics of these lesions are well documented. What is less well understood is the management implications of a patient diagnosed with LCIS; treatment regimes vary and are somewhat controversial. LCIS is now considered a risk factor and a non-obligate precursor for the subsequent development of invasive cancer.
authors.affiliation: The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Simpson
authors.forename: Theodora
authors.initials: T
authors.lastname: Gale
authors.forename: Laura G
authors.initials: LG
authors.lastname: Fulford
authors.forename: Jorge S
authors.initials: JS
authors.lastname: Reis-Filho
authors.forename: Sunil R
authors.initials: SR
authors.lastname: Lakhani
mesh_terms: D001943:Breast Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D018275:Carcinoma, Lobular / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006965:Hyperplasia; D009361:Neoplasm Invasiveness; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy