title: Frequent gains of 20q and losses of 18q are associated with lymph node metastasis in intestinal-type gastric cancer.
abstract: BACKGROUND
  The genetic aberrations associated with development and progression of gastric carcinomas (GCs) are poorly understood. The aim of this study was to identify chromosomal aberrations associated with the development and/or progression of intestinal-type GC.
  
  
  METHODS
  Comparative genomic hybridization (CGH) analysis was applied to 36 intestinal-type GCs. We compared chromosomal aberrations detected by CGH analysis with clinicopathological parameters.
  
  
  RESULTS
  Frequent gains of DNA copy number were found on 8q, 13q, 20q, 3q, 6q and losses were found on 17p, 18q in intestinal-type GCs. No significant differences were observed in the chromosomal aberrations between tumor stage, tumor location, peritoneal dissemination, liver metastasis or other distant metastasis. However, the frequencies of 20q12-13 gain and 18q21-22 loss were significantly higher in tumors with lymph node metastasis than in those without metastasis.
  
  
  CONCLUSIONS
  Gains of 20q and losses of 18q may contribute to lymph node metastasis and the malignant phenotype in intestinal-type GCs.
authors.affiliation: Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto Machi, Nagasaki City, Nagasaki 852-8501, Japan. hidaka-s@net.nagasaki-u.ac.jp
authors.forename: Shigekazu
authors.initials: S
authors.lastname: Hidaka
authors.forename: Toru
authors.initials: T
authors.lastname: Yasutake
authors.forename: Masamichi
authors.initials: M
authors.lastname: Kondo
authors.forename: Hiroak
authors.initials: H
authors.lastname: Takeshita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yano
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Haseba
authors.forename: Takashi
authors.initials: T
authors.lastname: Tsuji
authors.forename: Terumitsu
authors.initials: T
authors.lastname: Sawai
authors.forename: Tohru
authors.initials: T
authors.lastname: Nakagoe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tagawa
mesh_terms: D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D018450:Disease Progression; D006801:Humans; D008207:Lymphatic Metastasis; D009693:Nucleic Acid Hybridization; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm