title: Bilirubin adsorption column Medisorba BL-300.
abstract: Bilirubin adsorption column Medisorba BL-300 (Kuraray Medical Inc.) for the treatment of hyperbilirubinemia is introduced. The adsorbent packed in this column is the porous anion exchange resin coated with hydrophilic 2-hydroxyethyl methacrylate copolymer in order to improve blood compatibility. The adsorbent showed a high adsorption rate for direct bilirubin and indirect bilirubin in patient plasma in vitro. This column is used in plasmaperfusion therapy in clinical use. BL-300 showed high removal rate for direct bilirubin, indirect bilirubin and bile acid in clinical evaluation. BL-300 is approved in Japan and it has been used for the treatment of hyperbilirubinemia caused by many diseases such as liver failure and hepatitis.
authors.affiliation: Medical Products Development Department, Kuraray Medical Inc., Kurashiki, Okayama, Japan. shuhei_nakaji@kuraray.co.jp
authors.forename: Shuhei
authors.initials: S
authors.lastname: Nakaji
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hayashi
mesh_terms: D000327:Adsorption; D000837:Anion Exchange Resins / Q000737:chemistry*; D001663:Bilirubin / Q000097:blood; D002986:Clinical Trials as Topic; D006464:Hemoperfusion; D006801:Humans; D006932:Hyperbilirubinemia / Q000628:therapy*; D010951:Plasma Exchange / Q000379:methods; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D000837:Anion Exchange Resins; D001663:Bilirubin