Fatal interaction between tranylcypromine and imipramine.
This case report describes a patient on tranylcypromine who erroneously received a single dose of imipramine and subsequently developed a fatal serotonin syndrome. Both the clinical features and the pathophysiology of the serotonin syndrome are discussed.
Otte
Wim
W
Emergis Centre for Mental Health, Goes, The Netherlands.
Birkenhager
Tom K
TK
van den Broek
Walter W
WW
D018759:Adrenergic Uptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D014151:Anti-Anxiety Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy; D004347:Drug Interactions; D017809:Fatal Outcome; D006801:Humans; D007099:Imipramine / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020230:Serotonin Syndrome / Q000139:chemically induced*; D014191:Tranylcypromine / Q000009:adverse effects* / Q000627:therapeutic use
D018759:Adrenergic Uptake Inhibitors; D014151:Anti-Anxiety Agents; D014191:Tranylcypromine; D007099:Imipramine