title: Regulating transcription: a chemical perspective.
abstract: Many human diseases are characterized by altered gene expression patterns caused by malfunctioning transcriptional regulators. This has spurred new efforts in the development of artificial transcription factors that regulate the expression of specific genes either positively or negatively. Despite impressive advances in the last decade, artificial transcription factors that reconstitute all of the functions of natural regulators are not yet a reality. Such factors will be powerful chemical tools for unraveling the mechanisms by which gene expression is regulated and in the long term offer considerable therapeutic potential.
authors.affiliation: Department of Chemistry and Department of Medicinal Chemistry, University of Michigan, MI, USA.
authors.forename: Anna K
authors.initials: AK
authors.lastname: Mapp
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites / Q000235:genetics; D004247:DNA / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011485:Protein Binding; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D014157:Transcription Factors; D004247:DNA