title: The enigma of sepsis.
abstract: Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving. This review discusses the search for effective therapeutic interventions, hurdles in translational sepsis research, and new therapies in development in current clinical trials.
authors.affiliation: Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, Michigan 48109-0602, USA.
authors.forename: Niels C
authors.initials: NC
authors.lastname: Riedemann
authors.forename: Ren-Feng
authors.initials: RF
authors.lastname: Guo
authors.forename: Peter A
authors.initials: PA
authors.lastname: Ward
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D017209:Apoptosis; D002986:Clinical Trials as Topic; D015936:Complement C5a / Q000502:physiology; D024243:HMGB1 Protein / Q000502:physiology; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology; D011486:Protein C / Q000627:therapeutic use; D044087:Receptor, Anaphylatoxin C5a; D011951:Receptors, Complement / Q000502:physiology; D018805:Sepsis / Q000175:diagnosis* / Q000209:etiology* / Q000628:therapy*
chemical_list: D015703:Antigens, CD; D024243:HMGB1 Protein; D008263:Macrophage Migration-Inhibitory Factors; D011486:Protein C; D044087:Receptor, Anaphylatoxin C5a; D011951:Receptors, Complement; D015936:Complement C5a