title: Plasmodium falciparum cerebral malaria complicated by disseminated intravascular coagulation and symmetrical peripheral gangrene: case report and review.
abstract: The case of a 56-year-old female tourist who survived cerebral Plasmodium falciparum malaria with disseminated intravascular coagulation and symmetrical peripheral gangrene, ultimately requiring amputation of her left-sided fingertips and toes, is reported. While symmetrical peripheral gangrene has been described rarely in Asian, African, and American patients with Plasmodium falciparum malaria and disseminated intravascular coagulation, no such case has been reported in travelers returning from endemic areas.
authors.affiliation: Department of Medicine, University Hospital Zurich, 8091 Zurich, Switzerland.
authors.forename: M E
authors.initials: ME
authors.lastname: Liechti
authors.forename: V
authors.initials: V
authors.lastname: Zumsteg
authors.forename: C F R
authors.initials: CF
authors.lastname: Hatz
authors.forename: T
authors.initials: T
authors.lastname: Herren
mesh_terms: D000818:Animals; D004211:Disseminated Intravascular Coagulation / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D004318:Doxycycline / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005528:Foot; D005734:Gangrene / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D015600:Glasgow Coma Scale; D006801:Humans; D007262:Infusions, Intravenous; D016779:Malaria, Cerebral / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000302:isolation & purification*; D011803:Quinine / Q000008:administration & dosage; D012121:Respiration, Artificial; D018570:Risk Assessment; D012720:Severity of Illness Index; D014195:Travel; D016896:Treatment Outcome
chemical_list: D011803:Quinine; D004318:Doxycycline