title: Comparative study on conventional and low-flow nebulizers for arsenic speciation by means of microbore liquid chromatography with inductively coupled plasma mass spectrometry.
abstract: The performance of conventional and low-flow nebulizer systems with liquid chromatography in differentiating four arsenic species in urine was evaluated. Two low-flow (DIN and MCN) chamber assemblies and a conventional (CFN) nebulizer-spray chamber assembly were compared in the hyphenation of anion-exchange microbore liquid chromatography with inductively coupled plasma mass spectrometry. Under optimal analytical conditions, the detection limits of the four arsenic species were 0.2-0.6 ng ml(-1) for all the nebulizer systems tested. The chromatographic resolution was best in the case of DIN due to its minimal off-column dead volume and superior transport efficiency. Four arsenic species were determined in the certified reference materials NIST SRM 2670E and 2670N.
authors.affiliation: Nuclear Science and Technology Department Center, National Tsing-Hua University, 30043 Hsinchu, Taiwan. ycsun@mx.nthu.edu.tw
authors.forename: Y C
authors.initials: YC
authors.lastname: Sun
authors.forename: Y S
authors.initials: YS
authors.lastname: Lee
authors.forename: T L
authors.initials: TL
authors.lastname: Shiah
authors.forename: P L
authors.initials: PL
authors.lastname: Lee
authors.forename: W C
authors.initials: WC
authors.lastname: Tseng
authors.forename: M H
authors.initials: MH
authors.lastname: Yang
mesh_terms: D001151:Arsenic / Q000737:chemistry* / Q000302:isolation & purification; D002852:Chromatography, Ion Exchange / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D009330:Nebulizers and Vaporizers
chemical_list: D001151:Arsenic