title: A comparison of the haemostatic effect of Vivostat patient-derived fibrin sealant with oxidised cellulose (Surgicel) in multiple surgical procedures.
abstract: OBJECTIVE
  To evaluate the haemostatic properties of Vivostat patient-derived fibrin sealant in a broad range of surgical procedures.
  
  
  METHODS
  In a prospective, randomised, multicentre, clinical study, typical surgical wounds of 69 patients (cardiothoracic, general, obstetric and gynaecologic, and vascular), requiring intervention to control bleeding, were treated with either Vivostat-derived sealant (n = 35) or Surgicel (n = 34) as required and the time taken to arrest bleeding was assessed.
  
  
  RESULTS
  Compared with Surgicel, the mean time to haemostasis of Vivostat-derived sealant was significantly shorter (1.6 vs. 3.3 min, p < 0.0001) and more patients were successfully treated (i.e. no additional haemostatic measures required; 94 vs. 65%, p = 0.003).
  
  
  CONCLUSIONS
  Vivostat-derived sealant is a more reliable and rapidly effective surgical haemostat than Surgicel.
authors.affiliation: Department of Surgery, University of Virginia Health System, Charlotteville, VA, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Hanks
authors.forename: H K
authors.initials: HK
authors.lastname: Kjaergard
authors.forename: D A
authors.initials: DA
authors.lastname: Hollingsbee
mesh_terms: D000328:Adult; D000368:Aged; D002483:Cellulose, Oxidized / Q000627:therapeutic use*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006489:Hemostatic Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D002483:Cellulose, Oxidized; D015718:Fibrin Tissue Adhesive; C013695:Surgicel