title: 2,5-Disubstituted pyrrolidines: versatile regioselective and diastereoselective synthesis by enamine reduction and subsequent alkylation.
abstract: A direct and versatile route enabling the regio- and diastereoselective synthesis of 2,5-disubstituted pyrrolidines by reduction of enamines derived from pyroglutamic acid is reported.
authors.affiliation: The Department of Chemistry, Dyson Perrins Laboratory, The University of Oxford, South Parks Road, Oxford, OX1 3QY.
authors.forename: Syed Raziullah
authors.initials: SR
authors.lastname: Hussaini
authors.forename: Mark G
authors.initials: MG
authors.lastname: Moloney