title: A unique subpopulation of CD4+ regulatory T cells controls wasting disease, IL-10 secretion and T cell homeostasis.
abstract: CD25(+)CD4(+) regulatory T cells have major roles in controlling immune responses, and use heterogeneous regulatory mechanisms. It is possible that these different activities are mediated by different subsets. Here we show that CD103(+)CD25(+)CD4(+) T cells (that control inflammatory bowel disease) are highly enriched in gut-associated lymphoid tissue and have unique functional properties. In vivo, only this subpopulation is able to control wasting disease and peripheral T cell homeostasis. In vitro, only this subpopulation is able to regulate IL-10 secretion, and it might also mediate infectious suppression. These results demonstrate that regulatory T cells can be divided into discrete subpopulations with defined functional properties and regulatory mechanisms.
authors.affiliation: INSERM U. 591, Institut Necker, Paris, France. banz@necker.fr
authors.forename: Alice
authors.initials: A
authors.lastname: Banz
authors.forename: António
authors.initials: A
authors.lastname: Peixoto
authors.forename: Christiane
authors.initials: C
authors.lastname: Pontoux
authors.forename: Corinne
authors.initials: C
authors.lastname: Cordier
authors.forename: Benedita
authors.initials: B
authors.lastname: Rocha
authors.forename: Martine
authors.initials: M
authors.lastname: Papiernik
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D006706:Homeostasis / Q000502:physiology*; D016023:Integrins / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism*; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism; D018121:Receptors, Cytokine / Q000096:biosynthesis / Q000235:genetics; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000378:metabolism*; D019282:Wasting Syndrome / Q000378:metabolism*
chemical_list: D016207:Cytokines; D016023:Integrins; D012333:RNA, Messenger; D018121:Receptors, Cytokine; D015375:Receptors, Interleukin-2; C070709:integrin alphaEbeta7; D016753:Interleukin-10