title: Overexpression of bcl-2 in lymphocytes of psoriatic skin.
abstract: Bcl-2 overexpression in lymphocytes play an important part in immunological and inflammatory diseases. In the present study, we investigated the bcl-2 expression in dermal lymphocytes of psoriatic skin biopsy samples. From the archives of the Department of Pathology, Ondokuz Mayis University Medical School (Samsun, Turkey), tissue sections belonging to 28 psoriasis cases and 10 chronic non-specific inflammatory skin disease cases were immunohistochemically stained by bcl-2. Positive staining was semiquantitatively graded from 1+ to 4+. Of the 28 psoriasis cases 20 were found to express bcl-2. Our data suggest that bcl-2-mediated inflammation plays a part in the pathogenesis and recurrent character of psoriasis.
authors.affiliation: Department of Pathology, Ondokuz Mayis University Medical School, 55139 Kurupelit/Samsun, Turkey. leventy@omu.edu.tr
authors.forename: L
authors.initials: L
authors.lastname: Yildiz
authors.forename: S
authors.initials: S
authors.lastname: Bariş
authors.forename: N
authors.initials: N
authors.lastname: Senturk
authors.forename: B
authors.initials: B
authors.lastname: Kandemir
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D016022:Case-Control Studies; D005260:Female; D005786:Gene Expression Regulation; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism*; D011565:Psoriasis / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D005819:Genetic Markers; D019253:Proto-Oncogene Proteins c-bcl-2