title: The toxic and anti-feedant activity of 2H-pyridazin-3-one-substituted 1,3,4-oxadiazoles against the armyworm Pseudaletia separata (Walker) and other insects and mites.
abstract: The toxicities and anti-feedant activities of thirteen asymmetrical 1,3,4-oxadiazoles containing a 2H-pyridazin-3-one group were investigated. The compounds were shown to possess considerable activity in retarding the development of larvae of a number of Lepidoptera, but they were all inactive against Homoptera, Diptera and Acarina. The compounds had powerful anti-feedant activity comparable with that of azadirachtin. The toxic symptoms of the poisoned larvae indicated that the compounds were novel insect growth regulators with a mode of action that might be similar to the chitin-synthesis inhibition of oxadiazole compounds and/or the juvenile hormone effect of pyridazinone compounds.
authors.affiliation: Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, Shanghai, 200237, China.
authors.forename: Qingchun
authors.initials: Q
authors.lastname: Huang
authors.forename: Xuhong
authors.initials: X
authors.lastname: Qian
authors.forename: Gonghua
authors.initials: G
authors.lastname: Song
authors.forename: Song
authors.initials: S
authors.lastname: Cao
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects; D007605:Juvenile Hormones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D007915:Lepidoptera / Q000187:drug effects* / Q000254:growth & development; D008925:Mites / Q000187:drug effects*; D015394:Molecular Structure; D010069:Oxadiazoles / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D007605:Juvenile Hormones; D010069:Oxadiazoles