title: [Acute rheumatic fever: problems and outlooks].
abstract: The issue related with acute rheumatic fever still remains to be topical at the present stage, which is accentuated by a high prevalence of rheumatic heart diseases. The results of multiple studies point out at the presence of "rheumatogenetic" A-streptococcal strains possessing certain biological properties. Although there were no changes in the disease semiotics, the intensity degree of clinical signs went down, due to which an early diagnosis of the disease became more complicated. The issues related with the nosological classification of post-streptococcal reactive arthritis and with PANDAS syndrome need to be solved. There is also an urgent necessity in creating high-technological domestic benzathine-penicillins intended for secondary prevention of the disease.
authors.forename: B S
authors.initials: BS
authors.lastname: Belov
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D003937:Diagnosis, Differential; D004008:Diclofenac / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use; D010401:Penicillin G Benzathine / Q000008:administration & dosage / Q000627:therapeutic use; D012213:Rheumatic Fever / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control; D012214:Rheumatic Heart Disease / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control; D013290:Streptococcal Infections / Q000175:diagnosis / Q000188:drug therapy; D013297:Streptococcus pyogenes; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002317:Cardiovascular Agents; D004008:Diclofenac; D010401:Penicillin G Benzathine; D007213:Indomethacin