title: [Free flap pedicle loss: clinical study on 8 cases].
abstract: The authors report on 8 cases of free flaps with vascular pedicle disruption that were encountered between postoperative days 8 to 18. In one case, the inflow disappeared 18 months after the transfer without any trouble. This resulted in 2 partial and one complete flap losses. The 4 other flaps survived completely. This complete survival is related to the angiogenesis process coming from the surrounding tissues. The most obvious causal factor responsible for the 2 partial losses was the coverage of large, non viable areas, such as a prosthetic material and bone deprived of periosteum. The only causal factor that could be assessed in the case of total necrosis was the presence of an immunosuppressive treatment. Variables participating in the installation of an adequate angiogenic response are then discussed in accordance to this experience and to the literature. Limited contact with viable tissue, ischemia-reperfusion or drugs limiting the angiogenesis seems to promote failure when the pedicle is quickly disrupted. Hypoxia seems to be the most important cellular mechanism promoting the angiogenesis in this context.
authors.affiliation: Service de chirurgie plastique et maxillofaciale, CHU Sart-Tilman, B-4000 Liège, Belgique. maxiplast@ulg.ac.be
authors.forename: O
authors.initials: O
authors.lastname: Heymans
authors.forename: V
authors.initials: V
authors.lastname: Lemaire
authors.forename: L
authors.initials: L
authors.lastname: Preud'Homme
authors.forename: X
authors.initials: X
authors.lastname: Nélissen
authors.forename: N
authors.initials: N
authors.lastname: Verhelle
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D000860:Hypoxia; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D018919:Neovascularization, Physiologic; D011183:Postoperative Complications; D019651:Plastic Surgery Procedures; D012307:Risk Factors; D013524:Surgical Flaps; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents