title: Impact of dietary n-3 FA deficiency on rat bone tissue FA composition.
abstract: The effect of dietary n-3 FA deficiency on bone tissue FA composition was evaluated in growing rats. Two mixtures combining hydrogenated coconut oil with safflower oil served as the n-3-deficient dietary treatments and provided two levels of linoleic acid (LA). The n-3 treatments were formulated with added alpha-linolenic acid (LNA) from flaxseed oil (diet LNA) or LNA plus DHA, and both were balanced for LA. This study showed that bone is sensitive to changes in dietary n-3 FA and that DHA is more effective than LNA in maintaining DHA levels in these tissues.
authors.affiliation: Center for Enhancing Foods to Protect Health, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Greiner
authors.forename: Norman
authors.initials: N
authors.lastname: Salem
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Watkins
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000737:chemistry / Q000187:drug effects; D001842:Bone and Bones / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000494:pharmacology; D005227:Fatty Acids / Q000032:analysis*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000032:analysis*; D005260:Female; D005269:Femur / Q000737:chemistry / Q000187:drug effects; D008043:Linseed Oil / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D020318:Rats, Long-Evans; D013977:Tibia / Q000737:chemistry / Q000187:drug effects; D017962:alpha-Linolenic Acid / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D017962:alpha-Linolenic Acid; D004281:Docosahexaenoic Acids; D008043:Linseed Oil