title: Synthesis and hydrolysis studies of a peptide containing the reactive triad of serine proteases with an associated linker to a dye on a solid phase support.
abstract: The synthesis of a Tentagel-supported peptide incorporating the reactive triad of serine, histidine and aspartic acid, found within serine protease enzymes, is described.
authors.affiliation: Syngenta, Jealott's Hill Research Centre, Bracknell, Berkshire, UK RG42 6EY.
authors.forename: John M
authors.initials: JM
authors.lastname: Clough
authors.forename: Ray V
authors.initials: RV
authors.lastname: Jones
authors.forename: Hannah
authors.initials: H
authors.lastname: McCann
authors.forename: David J
authors.initials: DJ
authors.lastname: Morris
authors.forename: Martin
authors.initials: M
authors.lastname: Wills
mesh_terms: D000595:Amino Acid Sequence; D001224:Aspartic Acid / Q000737:chemistry / Q000378:metabolism; D004396:Coloring Agents / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004950:Esterases / Q000737:chemistry; D006639:Histidine / Q000737:chemistry / Q000378:metabolism; D006868:Hydrolysis; D008863:Microspheres; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D012694:Serine / Q000737:chemistry / Q000378:metabolism; D012697:Serine Endopeptidases / Q000737:chemistry* / Q000378:metabolism
chemical_list: D004396:Coloring Agents; D009842:Oligopeptides; D001224:Aspartic Acid; D012694:Serine; D006639:Histidine; D004950:Esterases; D012697:Serine Endopeptidases