Making recombinant proteins in animals--different systems, different applications.
Transgenic animal bioreactors represent a powerful tool to address the growing need for therapeutic recombinant proteins. The ability of transgenic animals to produce complex, biologically active recombinant proteins in an efficient and economic manner has stimulated a great deal of interest in this area. As a result, genetically modified animals of several species, expressing foreign proteins in various tissues, are currently being developed. However, the generation of transgenic animals is a cumbersome process and remains problematic in the application of this technology. The advantages and disadvantages of different transgenic systems in relation to other bioreactor systems are discussed.
Dyck
Michael K
MK
Centre de Recherche en Biologie de la Reproduction, Dépt des Sciences Animals, Pavillon Paul Comtois, Cité Universitaire, Université Laval, Sainte-Foy, Québec, Canada, G1K 7P4.
Lacroix
Dan
D
Pothier
François
F
Sirard
Marc-André
MA
D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics* / Q000502:physiology; D019149:Bioreactors / Q000191:economics; D001798:Blood Proteins / Q000235:genetics / Q000378:metabolism; D002478:Cells, Cultured; D003132:Commerce / Q000191:economics / Q000331:legislation & jurisprudence; D003257:Consumer Product Safety; D004777:Environment; D005818:Genetic Engineering / Q000941:ethics / Q000331:legislation & jurisprudence / Q000379:methods; D008894:Milk Proteins / Q000235:genetics / Q000378:metabolism; D010063:Ovum / Q000502:physiology; D010330:Patents as Topic / Q000331:legislation & jurisprudence; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000191:economics / Q000235:genetics; D012661:Semen / Q000502:physiology
D001798:Blood Proteins; D008894:Milk Proteins; D011994:Recombinant Proteins