Development of beta-keto 1,3-dithianes as versatile intermediates for organic synthesis.
beta-Keto 1,3-dithianes can be generated by the double conjugate addition of dithiols to propargylic ketones, esters and aldehydes in excellent yields. As masked 1,3-dicarbonyl systems these substrates can be converted to a range of functionalised oxygen-containing heterocycles that can be used in natural product synthesis.
Gaunt
Matthew J
MJ
University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW.
Sneddon
Helen F
HF
Hewitt
Peter R
PR
Orsini
Paolo
P
Hook
David F
DF
Ley
Steven V
SV