[Activity of cytokines in immunization with a vaccine against experimental tick-borne encephalitis].
An experimental double immunization of BALB/c mice with a vaccine against tick-borne encephalitis was accompanied by the production of IL-1b, IL-2, IL-4, IL-6, IL-10, IL-12, TNFa and gamma-IFN in the blood serum of animals. After the first immunization of animals with the vaccine against tick-borne encephalitis, the activity of cytokine was indicative of an activation of macrophages as well as of an activation and differentiation of T- and B-lymphocytes. After the second immunization and unlike the first one, there were changes in the production only of IL-10, IL-12 and gamma-IFN, which can be indicative of a regulation of balance between Th1 and Th2.
Ignat'ev
G M
GM
Otrashevskaia
E V
EV
Vorob'eva
M S
MS
D000818:Animals; D016207:Cytokines / Q000276:immunology*; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
D016207:Cytokines; D014765:Viral Vaccines