[An experimental study of gastric pacing on postsurgical gastric dynamic dysfunction].
OBJECTIVE
To probe the feasibility and curative effect of gastric pacing on postsurgical gastric dynamic dysfunction.


METHODS
Thirty-two rabbits were divided into four groups. The gastric dynamic indices of applying gastric pacing to the experimental animal model of acute post-vagotomy gastroparesis were compared with those of the groups treated with erythromycin (1 mg/kg).


RESULTS
The measurements of "gastroduodenal pressure at different sites" of the gastric pacing group and erythromycin group were higher than those of the before pacing group respectively (P < 0.001). The gastric pressure of the gastric pacing group was higher than that of the erythromycin group (P < 0.001). No significant difference in the duodenal pressure was observed between the above two groups (P > 0.05). The measurements of pressure at different sites (gastric fundus; gastric corpus; gastric antrum) after stopping pacing were higher than those of the erythromycin group, respectively (P < 0.01, P < 0.05, P < 0.05). The "pressure gradient between gastric antrum and duodenum" of the gastric pacing group was higher than that of the erythromycin group (P < 0.01). The gastric emptying rate of the gastric pacing group (64.41% +/- 6.66%) was significantly higher than that of the erythromycin group (53.73% +/- 7.09%) (P < 0.01).


CONCLUSIONS
Applying higher frequency gastric pacing can markedly enhance the gastric pressure, the pressure gradient between gastric antrum and duodenum, and the gastric emptying rate.
Li
Fuyu
F
Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Yu
Yunhai
Y
He
Sheng
S
Mao
Hui
H
D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D004917:Erythromycin / Q000627:therapeutic use; D005746:Gastric Emptying; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005769:Gastrointestinal Motility; D018589:Gastroparesis / Q000209:etiology / Q000628:therapy*; D011183:Postoperative Complications / Q000628:therapy*; D019736:Prostheses and Implants; D011817:Rabbits; D013270:Stomach; D014628:Vagotomy
D005765:Gastrointestinal Agents; D004917:Erythromycin