Effects of passive-avoidance training on sleep-wake state-specific activity in the basolateral and central nuclei of the amygdala.
This study examined the effects of intense emotional learning on the sleep-wake state-specific electroencephalographic (EEG) activities of the basolateral (BLA) and central (CeA) nuclei of the amygdala. Rats were trained on a passive-avoidance learning (PAL) protocol that was followed by 6 hr of undisturbed polygraphic recording and a PAL test. After PAL training, the total amount of REM sleep decreased: high-frequency EEG power decreased in the CeA during REM sleep and increased in the BLA during all sleep-wake stages. These results suggest that there is no homeostatic demand for REM sleep after intense emotional learning. However, the PAL-specific changes in the local EEG suggest that some form of memory processing may occur within the amygdala during REM sleep.
Mavanji
Vijayakumar
V
Department of Psychiatry, Boston University School of Medicine, Massachusetts 02118, USA.
Siwek
Donald F
DF
Patterson
Elissa H
EH
Spoley
Eric E
EE
Datta
Subimal
S
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning; D004569:Electroencephalography / Q000662:veterinary; D008297:Male; D008568:Memory; D051381:Rats; D017207:Rats, Sprague-Dawley; D012895:Sleep, REM / Q000502:physiology*