title: Cardiac dysfunction in portal hypertension among patients with cirrhosis and non-cirrhotic portal fibrosis.
abstract: OBJECTIVE
  In cirrhosis, diastolic dysfunction of heart is well documented. Contribution of portal hypertension towards cardiac changes in cirrhosis is difficult to assess. We examined the patients of non-cirrhotic portal fibrosis who have portal hypertension without liver insufficiency to understand the contribution of portal hypertension in causing cardiac changes.
  
  
  METHODS
  Cardiac function was studied in four groups of patients: normal controls, patients with non-cirrhotic portal fibrosis (having portal hypertension without liver dysfunction) and cirrhotics with and without ascites. Cardiac function was evaluated by echocardiography. Additional measurements of plasma renin activity and aldosterone levels were performed.
  
  
  RESULTS
  Diastolic function as assessed by the ratio between E wave and A wave (E/A ratio), was significantly lower in patients with non-cirrhotic portal fibrosis (median 1.3) compared to normal controls (median 1.52). However, even lower values were observed in cirrhotics without ascites (median 1.05) and with ascites (median 0.94). There was a significant correlation (r=-0.75) between plasma aldosterone levels and the E/A ratio in cirrhotics.
  
  
  CONCLUSIONS
  Diastolic dysfunction is not only present in cirrhosis but also in non-cirrhotic portal fibrosis. It indicates that portal hypertension is an important factor in the genesis of cardiac dysfunction.
authors.affiliation: Department of Medicine, Institute of Post Graduate Medical Education and Research, 244, Acharya J.C. Bose Road, 64/4A/1A, Dr. SC Banerjee Road, Calcutta 700 020, India. binaykde@apexmail.com
authors.forename: Binay K
authors.initials: BK
authors.lastname: De
authors.forename: Debabrata
authors.initials: D
authors.lastname: Majumdar
authors.forename: Debasish
authors.initials: D
authors.lastname: Das
authors.forename: Pranab K
authors.initials: PK
authors.lastname: Biswas
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Mandal
authors.forename: Sujay
authors.initials: S
authors.lastname: Ray
authors.forename: Kausik
authors.initials: K
authors.lastname: Bandopadhyay
authors.forename: Tapas K
authors.initials: TK
authors.lastname: Das
authors.forename: Sanjay
authors.initials: S
authors.lastname: Dasgupta
authors.forename: Supriya
authors.initials: S
authors.lastname: Guru
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D001794:Blood Pressure; D016022:Case-Control Studies; D003971:Diastole; D004452:Echocardiography; D005260:Female; D005355:Fibrosis; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology*; D008297:Male; D011168:Portal System / Q000473:pathology*; D012083:Renin / Q000097:blood
chemical_list: D000450:Aldosterone; D012083:Renin