[Effect of epithalamin on free-radical reactions in the formed elements of blood from breast cancer patients].
Translocation of cytomedins into the cell is determined by their interaction with cellular membranes. The investigation concerned membrane-associated free-radical reactions in the formed elements of blood incubated with epithalamin. The antioxidative effect of epithalamin on such elements as red blood cells and lymphocytes sampled from breast cancer patients manifested itself as enhanced activity of antioxidative enzymes and elevated concentrations of fat-soluble antioxidative vitamins in the membranes. These changes are likely to be brought about by the intensification of their regeneration from the oxidized forms. It is suggested that the stimulating effect of epithalamin on immunocompetent cells is due to its modulating influence on free-radical reactions. This effect gives epithalamin significant advantage over many immunotropic drugs and makes a case for its large-scale application for immunological rehabilitation of cancer patients.
Sidorenko
Iu S
IuS
Research Institute of Oncology, Rostov-on-Don.
Khavinson
V Kh
VKh
Vladimirova
L Iu
LIu
Frantsiiants
E M
EM
Musienko
N V
NV
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001773:Blood Cells / Q000187:drug effects* / Q000276:immunology*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000276:immunology*; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology; D005609:Free Radicals / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010455:Peptides / Q000494:pharmacology*; D014815:Vitamins / Q000378:metabolism
D000970:Antineoplastic Agents; D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D010455:Peptides; D014815:Vitamins; C027437:epithalamin