title: Treatment of myxoid liposarcoma by marginal or intralesional resection combined with radiotherapy.
abstract: Local recurrence-free survival rate for myxoid liposarcoma (MLS) is related to negative surgical margins. The goal of surgery in the treatment of MLS is to obtain tumor-free surgical margins. When a tumor is adjacent to critical structures, wider resection, which can result in amputation, would be selected for local control. While recognizing that marginal or intralesional resection is associated with high risk of recurrence, circumstances occur that lead surgeons to conduct conservative surgery. To determine whether marginal or intralesional resection combined with radiotherapy can achieve local control, 10 cases (12 tumors) were reviewed involving MLS treated with marginal (8 tumors) or intralesional resection (4 tumors) followed by postoperative radiotherapy (50-70 Gy, average 59.2 Gy). No recurrences of MLS were observed locally at the mean follow-up of 58.1 months. The development of severe radiation-related complications was not detected. This medium follow-up study suggested that this method can achieve a high rate of local control.
authors.affiliation: Department of Orthopedic Surgery, Niigata University School of Medicine, Niigata City, 950-8510, Japan. hatanoh@niigata-cc.niigata.niigata.jp
authors.forename: H
authors.initials: H
authors.lastname: Hatano
authors.forename: A
authors.initials: A
authors.lastname: Ogose
authors.forename: T
authors.initials: T
authors.lastname: Hotta
authors.forename: H
authors.initials: H
authors.lastname: Kawashima
authors.forename: T
authors.initials: T
authors.lastname: Sugita
authors.forename: R
authors.initials: R
authors.lastname: Sasamoto
authors.forename: N
authors.initials: N
authors.lastname: Endo
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D018208:Liposarcoma, Myxoid / Q000532:radiotherapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome