[Expression of annexin II in human esophageal squamous cell carcinoma].
OBJECTIVE
To evaluate the expression of annexin II in human esophageal squamous cell carcinoma (ESCC) and its relation with clinicopathological data.


METHODS
The expression of annexin II mRNA and protein in paired cancer tissues and their adjacent quasi-normal tissues were detected by RT-PCR, immunohistochemical method and densitometric scanning. The relation between annexin II expression and the status of tumor differentiation was analyzed.


RESULTS
The expression of annexin II was significantly lower in the tumor tissue than that in its paired normal counterpart both in mRNA and protein level (P < 0.05, P < 0.01). The protein expression of annexin II was significantly lower in moderately and poorly differentiated tumors than those in well differentiated ones (P < 0.05).


CONCLUSIONS
Down-regulation of annexin II in esophageal carcinogenesis may play an important role in squamous cell differentiation.
Zhang
Xun
X
Department of Pathology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
Zhi
Hui-ying
HY
Zhang
Jian
J
Wang
Xiu-qin
XQ
Zhou
Chuan-nong
CN
Wu
Min
M
Sun
Yun-tian
YT
Liu
Zhi-hua
ZH
D017306:Annexin A2 / Q000096:biosynthesis* / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D015536:Down-Regulation; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
D017306:Annexin A2; D012333:RNA, Messenger