Short-term biological effects of a new and less acidic fluid for peritoneal dialysis.
BACKGROUND
Conventional peritoneal dialysates are potentially bioincompatible and seem to be a causative factor for peritoneal sclerosis. Recent studies demonstrated that a new type of dialysate has a positive long-term clinical effect on dialysis patients.


METHODS
In this study, to elucidate the short-term biological effects of a newly developed dialysate of higher pH on the peritoneal membrane, we assessed macrophage proportions and several markers (inflammatory cytokines, cancer antigen 125 (CA125) and albumin) in spent dialysates before and 2 weeks after the change to the new fluid from a conventional fluid.


RESULTS
We found that the use of the new dialysate decreased intraperitoneal levels of inflammatory cytokines, CA125 and albumin associated with the decrease of macrophage populations in dialysis effluents.


CONCLUSIONS
These observations suggest that a new and less acidic fluid reduces pro-inflammatory potential in the peritoneum, and thus affords better preservation of peritoneal membrane integrity in uremic patients on peritoneal dialysis.
Matsumoto
Yoshihiro
Y
Department of Hemodialysis, Chukyo Hospital, Nagoya, Japan. matsumoto16@aol.com
Sato
Hideki
H
Miyai
Hironobu
H
Sato
Motoyoshi
M
Morita
Hiroyuki
H
Amano
Izumi
I
D015415:Biomarkers / Q000032:analysis; D018394:CA-125 Antigen / Q000032:analysis; D016207:Cytokines / Q000032:analysis; D015314:Dialysis Solutions / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007249:Inflammation / Q000175:diagnosis / Q000517:prevention & control; D008264:Macrophages / Q000166:cytology; D010530:Peritoneal Dialysis / Q000009:adverse effects / Q000379:methods*; D010537:Peritoneum / Q000187:drug effects / Q000473:pathology; D012709:Serum Albumin / Q000032:analysis
D015415:Biomarkers; D018394:CA-125 Antigen; D016207:Cytokines; D015314:Dialysis Solutions; D012709:Serum Albumin