Loading amplification of radiation grafted polymers (crowns and lanterns) and their application in the solid-phase synthesis of hydantoin libraries.
Solid-phase dendrimer chemistry using a symmetrical 1 --> 3 C-branched isocyanate monomer was used to prepare radiation-grafted polymers with enhanced loading. After evaluation of the physical and chemical properties of these new high-loading supports, they were tested in the multiple parallel synthesis of hydantoins.
Lebreton
Sylvain
S
Department of Chemistry, University of Southampton, Southampton, Hampshire SO17 1BJ, U.K.
Newcombe
Nicholas
N
Bradley
Mark
M
D020650:Combinatorial Chemistry Techniques; D003442:Crowns; D006827:Hydantoins / Q000138:chemical synthesis*; D008029:Lighting; D011108:Polymers / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry; D012117:Resins, Synthetic / Q000138:chemical synthesis
D006827:Hydantoins; D011108:Polymers; D011137:Polystyrenes; D012117:Resins, Synthetic