Detection of a silent myocardial infarction with phosphor-31 two-dimensional chemical shift imaging (31P 2-D CSI).
BACKGROUND
Phosphor-31 two-dimensional chemical shift imaging (3lP 2-D CSI) is a well-established noninvasive technique in experimental research on regional myocardial ischemia, and it permits in vivo monitoring of high-energy phosphate metabolism in the myocardium without requiring external tracers,wherein phosphocreatinine (PCr) and beta-adenosine triphosphate (beta-ATP) are the main components of investigation. The decrease of PCr is one of the earliest reactions to acute myocardial ischemia, but also fixed defects after myocardial infarction (MI) showed a reduced ratio of PCr/beta-ATP, probably because of are modeling process taking place in the noninfarcted tissue.


METHODS
A 55-year-old patient with diabetes mellitus type 1 is reported, who presented within the scope of a study at the University Hospital Innsbruck, Austria, and in whom 31P 2-D CSI helped to detect a so far unknown coronary heart disease (CHD).


CONCLUSIONS
In the presented case, 31P 2-D CSI for the first time helped to reveal a severe CHD and a so far unknown MI,and and if the calculated voxel size was chosen small enough, even a satisfying localization of the lesion became possible.
Steinboeck
Peter
P
Division of Cardiology, University Hospital Innsbruck, Austria.
Metzler
Bernhard
B
Schocke
Michael F H
MF
Lechleitner
Monika
M
Jaschke
Werner
W
Pachinger MD
Otmar
O
D000255:Adenosine Triphosphate / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D004562:Electrocardiography; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010759:Phosphorus Isotopes
D010710:Phosphates; D010759:Phosphorus Isotopes; D010725:Phosphocreatine; D000255:Adenosine Triphosphate