title: [Cell differentiation in human melanoma cells caused by dicarbamine (ultrastructural investigation)].
abstract: The effects of dicarbamine (r) and polytransretinoic acid (PTRA) on human melanoma MEL-6 transplanted into Balb/c nude female mice have been compared by histological and electron microscopic procedures. It was discovered that long-term administration of 1.5 mg/kg dicarbamine caused melanoma MEL-6 cells to undergo terminal differentiation. As a result, the number of melanosome-containing cells was 3-4 times and the number of melanosomes in them--5 times those in intact controls. Dicarbamine effect was double that of PTRA.
authors.affiliation: N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences.
authors.forename: N T
authors.initials: NT
authors.lastname: Raĭkhlin
authors.forename: V E
authors.initials: VE
authors.lastname: Nebol'sin
authors.forename: G A
authors.initials: GA
authors.lastname: Zheltukhina
authors.forename: I P
authors.initials: IP
authors.lastname: Bryzgalov
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Sorokina
authors.forename: N V
authors.initials: NV
authors.lastname: Andronova
authors.forename: L A
authors.initials: LA
authors.lastname: Sedakova
authors.forename: E A
authors.initials: EA
authors.lastname: Smirnova
authors.forename: E M
authors.initials: EM
authors.lastname: Treshchalina
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002219:Carbamates / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D006801:Humans; D007150:Immunohistochemistry; D008543:Melanins / Q000032:analysis*; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000648:ultrastructure*; D020460:Melanosomes / Q000737:chemistry / Q000187:drug effects*; D051379:Mice; D008819:Mice, Nude; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D002219:Carbamates; D008543:Melanins; D014212:Tretinoin