[Stability evaluation of thymopentin in preparation process].
OBJECTIVE
To observe whether thymopentin is stable in the preparation process.


METHODS
Using HPLC method, we investigated the influence of different temperature, sonification time and pH value on thymopentin.


RESULTS
The optimum storage condition for preservation of thymopentin was found to be a freezing environment. Thymopentin would not be degraded in the water bath of 60 degrees C for 24 hours or in different phosphate buffer solution (PBS) (pH 2, 5, 5, 7) under 37 degrees C for 24 hours. The sonification time within 15 minutes was determined to be safe for the preparation.


CONCLUSIONS
The experiment result indicates that thymopentin is stable during the whole preparation process.
He
Weiling
W
Department of Pharmaceutics, West China Pharmacy School, Sichuan University, Chengdu 610041, China.
Zhang
Zhirong
Z
Jiang
Xuehua
X
Nie
Yu
Y
Wu
Fang
F
D002851:Chromatography, High Pressure Liquid; D003080:Cold Temperature; D004355:Drug Stability; D013678:Technology, Pharmaceutical; D013696:Temperature; D016305:Thymopentin / Q000032:analysis*; D013946:Thymopoietins / Q000138:chemical synthesis
D013946:Thymopoietins; D016305:Thymopentin