Conformational analysis by HRMAS NMR spectroscopy of resin-bound homo-peptides from C(alpha)-methyl-leucine.
A series of [L-(alphaMe)Leu]n (n = 1-5) homo-peptides have been covalently linked to Tentagel and POEPOP resins and submitted to a conformational study using HRMAS NMR spectroscopy. Whereas the mono- and dipeptide are mainly fully-extended, stable 3(10)-helical structures are formed beginning from the trimer.
Rainaldi
Mario
M
Institute of Biomolecular Chemistry, CNR, Department of Organic Chemistry, University of Padova, 35131 Padova, Italy.
Lancelot
Nathalie
N
Elbayed
Karim
K
Raya
Jesus
J
Piotto
Martial
M
Briand
Jean-Paul
JP
Kaptein
Bernard
B
Broxterman
Quirinus B
QB
Berkessel
Albrecht
A
Formaggio
Fernando
F
Toniolo
Claudio
C
Bianco
Alberto
A
D007930:Leucine / Q000031:analogs & derivatives*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D009842:Oligopeptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D012117:Resins, Synthetic
D009842:Oligopeptides; D012117:Resins, Synthetic; D007930:Leucine