title: A novel traceless solid-phase Friedländer synthesis.
abstract: [reaction: see text] A new solid-phase synthesis of quinolines based on a Friedländer-type reaction between the resin-bound azomethine 1b and ketones 2 is described. This cyclative cleavage approach affords quinolines 3a-f in 50-81% yields. The polymer-bound aniline equivalent is easily recycled and may be reused with comparable performance.
authors.affiliation: Laboratoire de Chimie Organique Fine et Hétérocyclique UMR 6014, IRCOF-INSA, rue Tesnières B.P 08, F-76131 Mont Saint Aignan Cedex, France.
authors.forename: Claudine
authors.initials: C
authors.lastname: Patteux
authors.forename: Vincent
authors.initials: V
authors.lastname: Levacher
authors.forename: Georges
authors.initials: G
authors.lastname: Dupas