Panniculitis secondary to extravasation of clarithromycin in a patient with alpha 1-antitrypsin deficiency (phenotype PiZ).
alpha 1-Antitrypsin deficiency (AATD) is known to be associated with panniculitis. Although reports of this association are rare, the true incidence may be unappreciated because of underdiagnosis of AATD. We report a case of panniculitis occurring in a 34-year-old woman with severe AATD following the extravasation of clarithromycin infused intravenously for treatment of community-acquired pneumonia. Resolution occurred with conservative management. The histopathology and management of this unusual condition are discussed, with a review of the literature.
Parr
D G
DG
Department of Pulmonology, University Hospital Birmingham, Birmingham, UK.
Stewart
D G
DG
Hero
I
I
Stockley
R A
RA
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D017291:Clarithromycin / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000150:complications; D005260:Female; D005542:Forearm / Q000473:pathology; D006801:Humans; D015434:Panniculitis / Q000139:chemically induced*; D019896:alpha 1-Antitrypsin Deficiency / Q000150:complications*
D000900:Anti-Bacterial Agents; D017291:Clarithromycin