[Relationship between Ala98Val variant of hepatocyte nuclear factor-1 alpha gene and late-onset type 2 diabetes in Han nationality].
OBJECTIVE
To ascertain whether Ala98Val variant in exon 1 of hepatocyte nuclear factor-1 alpha (HNF-1 alpha) gene is associated with late-onset Type 2 diabetes in Chinese Han nationality.


METHODS
We selected 150 patients with late-onset Type 2 diabetes and 155 controls, and detected Ala98Val variant with polymerase chain reaction-single strand conformational polymorphism(PCR-SSCP) and direct sequencing.


RESULTS
None of Ala98Val variant was found in all of the subjects.


CONCLUSIONS
The Ala98Val variant doesn't play an important role in late-onset Type 2 diabetes in Chinese Han nationality.
Deng
Hao
H
National Laboratory of Medical Genetics, Central South University, Changsha 410078, China.
Tang
Wei-li
WL
Liu
Zheng
Z
D000293:Adolescent; D000328:Adult; D000409:Alanine / Q000235:genetics; D019943:Amino Acid Substitution; D044466:Asian People; D004268:DNA-Binding Proteins / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005006:Ethnicity; D005260:Female; D014644:Genetic Variation; D051537:Hepatocyte Nuclear Factor 1; D051538:Hepatocyte Nuclear Factor 1-alpha; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D017422:Sequence Analysis, DNA; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; D009687:Nuclear Proteins; D014157:Transcription Factors; D051537:Hepatocyte Nuclear Factor 1; D000409:Alanine