title: A pincer auxiliary to force difficult lactamisations.
abstract: A new method to cyclise peptides is reported based on insertion of a salicylaldehyde derived pincer auxiliary in the linear precursor sequence. H-betaAla-Phe-OH and H-Phe-betaAla-OH were chosen as representative model peptides.
authors.affiliation: Institute of Molecular Chemistry, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands.
authors.forename: Hans
authors.initials: H
authors.lastname: Bieräugel
authors.forename: Hans E
authors.initials: HE
authors.lastname: Schoemaker
authors.forename: Henk
authors.initials: H
authors.lastname: Hiemstra
authors.forename: Jan H
authors.initials: JH
authors.lastname: van Maarseveen
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000595:Amino Acid Sequence; D003500:Cyclization; D007769:Lactams / Q000138:chemical synthesis*; D009842:Oligopeptides / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D007769:Lactams; D009842:Oligopeptides; D010456:Peptides, Cyclic; C013243:salicylaldehyde