title: [Presence of anti-Helicobacter pylori, antithyroid, and high-affinity IgE receptor antibodies in patients with chronic urticaria].
abstract: BACKGROUND
  Chronic urticaria is characterized by erythematous wheals during more than 6 weeks. In 47% of the patients it is associated to Helicobacter pylori infection; in 50%, to antibodies (Abs) against the high affinity receptor of the IgE, and in 12 to 20% to antithyroid's antibodies (antithyroglobuline, mychrosomals) and, from these, 25% have alterations of the thyroid function.
  
  
  OBJECTIVE
  To determine the presence of the anti-Helicobacter pylori and anttihyroids antibodies and the high affinity anti-receptor of the IgE in healthy subjects and patients with chronic urticaria.
  
  
  METHODS
  Eighty subjects were included: 40 healthy subjects and 40 patients whit diagnosis of chronic urticaria. In all of them a blood sample was extracted to the determination of the antibodies and skin test applications with autologous serum to determine the antibody of the high affinity anti-receptor of IgE. For the analysis of the results descriptive statistics was used (central tendency measures, frequencies, means, averages and percentages), as well as multiple correlations and inferential analyses.
  
  
  RESULTS
  Anti-Helicobacter pylori, antithyroid (antithyroglobulin, microsomal) antibodies and the skin test with autologous serum (antibody of the high affinity anti-receptor of IgE) were negative in the healthy group (mean age: 41 years, 36 women, 90%). Of the 40 patients with chronic urticaria (mean age: 42 years, 36 women, 90%), the frequency of the antibody of high affinity anti-receptor of the IgE was: 5 patients with negative skin test (12.5%), 1 (2.5%)+, 7 (17.5%)++, 9 (22.5%)+++, 18 (45%)++++. The anti-Helicobacter pylori antibodies were positive in 30 (75%) patients and negative in 10 (25%). The antithyroid's antibodies were as follows: antithyroglobulin: 4 (10%) positive, microsomal: 4 (10%) positive. The concomitant diseases found were: hypothyroidism (3, 7.5%) mixed rhinitis (2.5%) and autoimmunity 2 (5%).
  
  
  CONCLUSIONS
  The test skin with autologous serum to determine the IgG antibody against the high affinity receptor of IgE is a simple and low-cost procedure leading to determine the cause of the idiopathic chronic urticaria in a high percentage of patients. As reported in literature, the Helicobacter pylori infection documented by the detection of the IgM antibodies against Helicobacter pylori is frequent in patients with chronic urticaria, which is important due to it could be implied in the diagnosis and treatment.
authors.affiliation: Servicio de Inmunologia Clinica y Alergia, Centro Médico Nacional 20 de Noviembre Coyoacán y Félix Cuevas, col. Del Valle, México, DF, CP 03229.
authors.forename: Luciana
authors.initials: L
authors.lastname: Alcaraz Calderón
authors.forename: David
authors.initials: D
authors.lastname: Escárcega Barbosa
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Castrejón Vázquez
authors.forename: Jorge
authors.initials: J
authors.lastname: Galicia Tapia
authors.forename: Silvia
authors.initials: S
authors.lastname: Cano Altamirano
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Angeles Rivera
authors.forename: Iliana
authors.initials: I
authors.lastname: Zayde Palma Nájera
authors.forename: Alfonso Javier
authors.initials: AJ
authors.lastname: Miranda Feria
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D000961:Antilymphocyte Serum / Q000097:blood / Q000276:immunology; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017455:Receptors, IgE / Q000276:immunology*; D012220:Rhinitis / Q000150:complications / Q000276:immunology; D012882:Skin Tests; D014581:Urticaria / Q000150:complications / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000961:Antilymphocyte Serum; D001323:Autoantibodies; D007074:Immunoglobulin G; D017455:Receptors, IgE; C056626:thyroid microsomal antibodies