TACN-amino acid conjugates and their copperII complexes.
Triazacyclononane (TACN) was coupled to glycine (L(Gly)), alanine (L(Ala)), and phenylalanine (L(Phe)) via standard solution phase peptide coupling techniques. Copper(II) complexes of these new ligand-amino acid conjugates, [(CuL(Gly))(2)](ClO(4))(4) (1), [(CuL(Ala))(2)Cl](ClO(4))(3) (2), and [Cu(2)L(Phe)Cl(4)] (3), were synthesized and characterized. The X-ray crystal structures of 2 and 3 were determined. Complex 2 is a dimeric species where L(Ala) bridges between copper ions via its two TACN amine nitrogen atoms to one copper while the Ala terminal amine and carbonyl oxygen bind to the other copper. Complex 3 is bimetallic but only contains one L(Phe) ligand that bridges between the copper ions.
Mondal
Arunendu
A
Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Norman, Oklahoma 73019, USA.
Klein
Eric L
EL
Khan
Masood A
MA
Houser
Robert P
RP
D000596:Amino Acids / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004578:Electron Spin Resonance Spectroscopy; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D010880:Piperidines / Q000737:chemistry*
D000596:Amino Acids; D001372:Aza Compounds; D008024:Ligands; D010880:Piperidines; C482777:triazacyclononane; D003300:Copper