title: [Animal model study of guided bone tissue regeneration around implant by titanium membrane].
abstract: OBJECTIVE
  To evaluate the titanium membrane-guided bone tissue regeneration around implant and HA granules.
  
  
  METHODS
  Three adult cross-bred dogs were used. In the animal's mandible, man-made bone damaged regions (diameter 6.5 mm, depth 4 mm) being concentric with the implant holes were prepared. The implants were planted into the holes and were rendered to separate the damaged regions into two parts with two titanium sheets. One part was filled with HA granules while the other with nothing. Histological evaluation was done at 4, 8 and 12 weeks of implantation.
  
  
  RESULTS
  The bone around the implants grew obviously at 4 weeks; the bone grew more and the structure of the bone was similar to that of the normal bone at 12 weeks.
  
  
  CONCLUSIONS
  As a new type of GTR materials, titanium membrane can keep the existence of spaces underneath. HA granules can give guiding effects to bone tissue regeneration.
authors.affiliation: Department of Prosthetics, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Bao
authors.forename: Xing
authors.initials: X
authors.lastname: Liang
authors.forename: Xinghong
authors.initials: X
authors.lastname: Li
authors.forename: Weimin
authors.initials: W
authors.lastname: Gao
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D004195:Disease Models, Animal; D004285:Dogs; D048091:Guided Tissue Regeneration; D006882:Hydroxyapatites; D008297:Male; D019736:Prostheses and Implants; D014025:Titanium
chemical_list: D006882:Hydroxyapatites; D014025:Titanium