How can enzymes be so efficient?
Dudley Williams and his colleagues discuss how ligands can gain binding energy to their receptors, and substrate transition states to their enzymes, by tightening the protein structures, with a decrease in their dynamic behaviour.
Williams
Dudley H
DH
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Stephens
Elaine
E
Zhou
Min
M
D001665:Binding Sites; D001667:Binding, Competitive; D004789:Enzyme Activation; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D008024:Ligands; D008956:Models, Chemical; D010100:Oxygen / Q000737:chemistry; D011485:Protein Binding / Q000235:genetics / Q000502:physiology
D004798:Enzymes; D008024:Ligands; D010100:Oxygen