Asymmetric autocatalysis induced by chiral hydrocarbon [2.2]paracyclophanes.
Chiral hydrocarbon [2.2]paracyclophanes act as chiral initiators in asymmetric autocatalysis in the addition of diisopropylzinc to pyrimidine-5-carbaldehyde and give highly enantiomerically enriched 5-pyrimidyl alkanol with a reversed sense of the enantioselectivity to that of other [2.2]paracyclophanes with heteroatoms.
Sato
Itaru
I
Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo, 162-8601, Japan.
Ohno
Atsushi
A
Aoyama
Yohei
Y
Kasahara
Toshinari
T
Soai
Kenso
K