[Modification of rat behavioral reactions by peptides secreted by olfactory cortex cells upon their tetanization].
We studied neurotrophic properties of neuropeptide extracts from tetanized slices of the rat olfactory cortex. Two types of the extracts were studied, EP and ED, obtained from perfusates of the tetanized slices after long-term potentiation and from the slices after long-term depression, respectively. The effects of these two extracts were tested on rats using the open field and passive avoidance tests upon intranasal administration of the extracts (ca. 1 ng total protein). EP showed a neurotropic effect combined with a moderate sedative-hypnotic effect, while EP had obvious neurotropic and nootropic properties, affecting mainly the mechanisms of memory consolidation, and had an activating effect combined with a minor, delayed sedative effect. The functional significance of the secreted endogenous neuropeptides and the mechanisms of their effects are discussed.
Mokrushin
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AA
Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034 Russia.
Pavlinova
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D000281:Administration, Intranasal; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009833:Olfactory Pathways / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D010455:Peptides / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010455:Peptides