The genetic background as a determinant of human T-cell leukemia virus type 1 proviral load.
Human T-cell leukemia virus type 1 (HTLV-1) is etiologically linked with HTLV-1-associated diseases. HTLV-1 proviral load is higher in persons with adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis than in asymptomatic carriers. However there are little data available on the factors controlling HTLV-1 proviral load in carriers. To study the effect of genetic background on HTLV-1 proviral load, we employed a mouse model of HTLV-1 infection that we had established. Here we analyzed nine strains of mice and found there is a great variation of proviral load among mouse strains that is not necessarily dependent on major histocompatibility complex. The antibody response is also different among these strains. To our knowledge, this is the first demonstration of the importance of the genetic background other than major histocompatibility complex controlling the HTLV-1 proviral load.
Nitta
Takayuki
T
Department of Biochemistry and Molecular Oncology, Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba Science City, Ibaraki, Japan.
Tanaka
Masakazu
M
Sun
Binlian
B
Hanai
Shuji
S
Miwa
Masanao
M
D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000378:metabolism; D015490:HTLV-I Infections / Q000235:genetics / Q000276:immunology; D006579:Heterozygote; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D015458:Leukemia, T-Cell / Q000821:virology; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D013045:Species Specificity; D013154:Spleen / Q000378:metabolism; D019562:Viral Load
D004247:DNA