title: Are biosensor arrays in one membrane possible? A combination of multifrequency impedance measurements and chemometrics.
abstract: A novel concept of a membrane-based micro-array biosensor is presented. The methodology is based on a single lipid membrane interrogated with electrochemical impedance techniques followed by multivariate data analysis. A single membrane is designed so that relaxation processes with a range of time constants can be probed at different potentials. A range of other approaches cited in the literature is reviewed.
authors.affiliation: Department of Chemistry: Biophysical Chemistry, Umeå University, 901 87, Umeå, Sweden. britta.sethson@chem.umu.se
authors.forename: Britta
authors.initials: B
authors.lastname: Lindholm-Sethson
authors.forename: Josefina
authors.initials: J
authors.lastname: Nyström
authors.forename: Paul
authors.initials: P
authors.lastname: Geladi
authors.forename: Roger
authors.initials: R
authors.lastname: Koeppe
authors.forename: Andrew
authors.initials: A
authors.lastname: Nelson
authors.forename: Conor
authors.initials: C
authors.lastname: Whitehouse
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004563:Electrochemistry; D006096:Gramicidin / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D008564:Membrane Potentials; D008670:Metals / Q000737:chemistry; D015999:Multivariate Analysis
chemical_list: D008051:Lipid Bilayers; D008670:Metals; D006096:Gramicidin