Making and repairing the mammalian brain--in vitro production of dopaminergic neurons.
Midbrain dopamine (DA) neurons play an essential role in modulating motor control, and their degeneration is the hallmark feature of Parkinson's disease (PD). In vitro production of DA neurons provides insight into the mechanisms that control cell fate choice, and offers an alternative to the use of fetal tissue for experimental cell replacement in PD. Here we will review the advantages and disadvantages of the various renewable cell sources and protocols tested, and discuss their relevance for basic studies and for cell therapy.
Perrier
Anselme L
AL
Laboratory of Stem Cell & Tumor Biology, Neurosurgery and Developmental Biology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 256, New York, NY 10021, USA.
Studer
Lorenz
L
D000818:Animals; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D008322:Mammals; D009474:Neurons / Q000166:cytology*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*
D004298:Dopamine