title: Genetic variability of immunomodulatory genes in ectromelia virus isolates detected by denaturing high-performance liquid chromatography.
abstract: The genetic variability of nine genes in 12 isolates and strains of ectromelia virus, which causes a smallpox-like disease (mousepox) in mice, was determined and allows for classification of ectromelia viruses. The low genetic variability suggests that evolutionary pressure maintains the activity of immunomodulatory genes in natural poxvirus infections.
authors.affiliation: MRC UK HGMP Resource Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SB, UK.
authors.forename: Gloria
authors.initials: G
authors.lastname: Ribas
authors.forename: Jose
authors.initials: J
authors.lastname: Rivera
authors.forename: Margarida
authors.initials: M
authors.lastname: Saraiva
authors.forename: R Duncan
authors.initials: RD
authors.lastname: Campbell
authors.forename: Antonio
authors.initials: A
authors.lastname: Alcami
mesh_terms: D000595:Amino Acid Sequence; D005075:Biological Evolution; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004481:Ectromelia virus / Q000145:classification / Q000235:genetics*; D005814:Genes, Viral; D014644:Genetic Variation; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction