title: Localized aggressive periodontitis in primary dentition: a case report.
abstract: BACKGROUND
  A 5-year-old Japanese boy presented with persistent gingival inflammation and severe mobility of the right lower primary incisors. Due to severe alveolar bone loss and a deep periodontal pocket (5 mm), the incisors were extracted at the second visit.
  
  
  METHODS
  Clinical, radiographic, histological, and microbiological examinations were carried out. Then, the polymerase chain reaction (PCR) technique was employed to detect specific periodontal pathogens. The chemotactic activity of polymorphonuclear neutrophils was also measured.
  
  
  RESULTS
  Tannerella, Capnocytophaga, Fusobacterium, and Eikenella sp. were recovered from the subgingival microflora around the right lower incisors, while A. actinomycetemcomitans, Tannerella forsythensis (formerly Bacteroides forsythus), Prevotella nigrescens, Campylobacter rectus, and Capnocytophaga gingivalis were detected using the PCR method. Further chemotaxis assay revealed that neutrophil function was depressed compared with that of healthy controls.
  
  
  CONCLUSIONS
  Although inflammation remained around the right primary second molars, the bone loss was controlled by periodic professional mechanical teeth cleaning (PMTC), subgingival irrigation, and local antibiotic application. The probing depths of all teeth, including permanent incisors and molars, were within 2.5 mm.
authors.affiliation: Department of Pediatric Dentistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan. Junji-hma@umin.ac.jp
authors.forename: Junji
authors.initials: J
authors.lastname: Suzuki
authors.forename: Mitsugi
authors.initials: M
authors.lastname: Okada
authors.forename: Yurong
authors.initials: Y
authors.lastname: Wang
authors.forename: Noriko
authors.initials: N
authors.lastname: Nii
authors.forename: Kazuo
authors.initials: K
authors.lastname: Miura
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Kozai
mesh_terms: D016301:Alveolar Bone Loss / Q000175:diagnosis / Q000382:microbiology; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000502:physiology; D010518:Periodontitis / Q000175:diagnosis* / Q000382:microbiology; D014094:Tooth, Deciduous / Q000473:pathology*