title: Effects of perivagal administration of capsaicin on post-surgical food intake.
abstract: The vagus nerve has been related to the short-term control of food intake. This involvement has previously been explored by examining the food intake of animals after recovery from a vagotomy or immediately after the intervention, among other methods. In the present work, a study was conducted on the impact of the perivagal application of capsaicin (a specific neurotoxic treatment that destroys most of the vagal afferent pathways) on the intake of water and solid (experiment 1) or liquid (experiment 2) food presented after the surgery The results of experiment 1 showed that lesioned animals consume significantly larger amounts of food and water compared with controls at 6, 12, and 24 h (but not at 48 or 72 h) after the surgical intervention. Likewise, experiment 2 revealed a greater intake of liquid food by capsaicin-treated animals at the first post-surgical sessions. These data are discussed in terms of the role played by vagal afferent fibers in the control of short-term food intake.
authors.affiliation: Psychobiology Area, Department of Experimental Psychology and Physiology of Behavior, University of Granada, Campus de Cartuja, Granada, 18071, Spain. mazafra@ugr.es
authors.forename: Maria A
authors.initials: MA
authors.lastname: Zafra
authors.forename: Filomena
authors.initials: F
authors.lastname: Molina
authors.forename: Amadeo
authors.initials: A
authors.lastname: Puerto
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002211:Capsaicin / Q000008:administration & dosage* / Q000494:pharmacology; D004326:Drinking / Q000187:drug effects / Q000502:physiology; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009498:Neurotoxins / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014628:Vagotomy / Q000379:methods; D014630:Vagus Nerve / Q000187:drug effects* / Q000601:surgery
chemical_list: D009498:Neurotoxins; D002211:Capsaicin