title: Manometric evaluation of esophageal-protective reflexes in infants and children.
abstract: In adults, esophageal motor responses facilitate forward, or aboral, transit during swallowing, and protect the aerodigestive tract during retrograde movement of the bolus, which may occur with gastroesophageal reflux. It is unclear in the pediatric literature whether the activation of appropriate esophageal motor defense responses occurs during these events in infants. This investigation therefore studied the esophageal motor responses during the basal state and upon esophageal stimulation in infants. Using the water-perfusion manometry technique and a specially designed manometric catheter, 3 likely mechanisms that may protect the aerodigestive tract were recognized: secondary peristalsis, esophago-upper esophageal sphincter contractile reflex, and esophagodeglutition response.
authors.affiliation: Children's Research Institute, Columbus Children's Hospital, Department of Pediatrics, College of Medicine and Public Health, Ohio State University, Columbus 43205, USA.
authors.forename: Sudarshan R
authors.initials: SR
authors.lastname: Jadcherla
mesh_terms: D002648:Child; D002675:Child, Preschool; D003679:Deglutition; D004943:Esophagogastric Junction / Q000503:physiopathology*; D005764:Gastroesophageal Reflux / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D008365:Manometry / Q000379:methods; D010528:Peristalsis