[Discovery of analogous balanced translocation syndrome and its clinical genetics research].
OBJECTIVE
To find out the clinical genetic law of relation between a group of special chromosomal structural abnormality including bit Y, inv(9), S+, No. 1, 9, 16 chromosomal qh+/-, and the balanced translocation.


METHODS
By means of binomial distribution method, 980 cases were analyzed for balanced chromosome translocation, big Y, inv(9), S+ and qh+/-, and according to the clinical features the 980 cases were divided into 4 groups: spontaneous abortion, abnormal sexual development, labouring disease and disabled or diseased condition of the patient.


RESULTS
In these 980 cases of balanced translocation, big Y, inv(9), S+ and qh+/-, the chief clinical features caused by the various different conditions have a high similarity (P > 0.20-0.50).


CONCLUSIONS
The big Y, inv(9), S+, and qh+/- leading to the occurrence of the chief clinical features belong to the analogous balanced translocation syndrome. This fact indicates that in the process of sexual reproduction, the minute unequivalent exchange in the molecular level of gamete is possible to have genetic effect in the descendants, and may cause a corresponding clinical feature, present the abnormal sex differentiation, in varying degrees, and influence the abnormal phenotype or the health of individuals.
Cheng
Sheng-xiang
SX
Human Reproduction Engineering Research Institute, Xiangya School of Medicine, Central South University, Changsha 410008, China.
Liu
Li
L
Wu
Han-wen
HW
D000026:Abortion, Habitual / Q000235:genetics; D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D007446:Chromosome Inversion; D002899:Chromosomes, Human, Pair 9; D041322:Chromosomes, Human, Y; D012734:Disorders of Sex Development / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D011995:Recombination, Genetic; D014178:Translocation, Genetic