Efficiency of ultralow doses of antibodies to S100 protein and delta sleep-inducing peptide in rats with anxious depression.
We studied the effects of single peroral treatment with antibodies against S100 protein and delta sleep-inducing peptide in ultralow doses on behavioral characteristics of rats with anxious depression produced by acute stress (unavoidable electrical shock). Stress-produced behavioral changes and anxiolytic activity of antibodies were determined using the elevated plus-maze, open field, and tail suspension tests. High efficiency of the mixture of antibodies against S100 protein and delta sleep-inducing peptide was observed in all tests. Anxiolytic activity of anti-S100 antibodies (although less pronounced than that of the mixture of antibodies) was revealed in the elevated plus-maze and tail suspension test.
Loskutova
L V
LV
Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Shtark
M B
MB
Epstein
O I
OI
D000818:Animals; D014151:Anti-Anxiety Agents / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D003701:Delta Sleep-Inducing Peptide / Q000037:antagonists & inhibitors* / Q000276:immunology; D003863:Depression / Q000188:drug therapy; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D009418:S100 Proteins / Q000037:antagonists & inhibitors* / Q000276:immunology; D013312:Stress, Physiological
D014151:Anti-Anxiety Agents; D000906:Antibodies; D009418:S100 Proteins; D003701:Delta Sleep-Inducing Peptide