title: Signaling via Toll-like receptor 5 can initiate inflammatory mediator production by murine osteoblasts.
abstract: Murine osteoblasts express Toll-like receptor 5 (TLR5), and this expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Importantly, flagellin activates transcriptional regulators and elicits proinflammatory cytokine production, suggesting TLR5 functionality. TLR5 may represent an important mechanism underlying the recognition of bacterial pathogens by osteoblasts during bone infections.
authors.affiliation: Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA.
authors.forename: Denise R
authors.initials: DR
authors.lastname: Madrazo
authors.forename: Susanne L
authors.initials: SL
authors.lastname: Tranguch
authors.forename: Ian
authors.initials: I
authors.lastname: Marriott
mesh_terms: D000818:Animals; D001483:Base Sequence; D001850:Bone Diseases, Infectious / Q000209:etiology / Q000276:immunology / Q000382:microbiology; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis; D004247:DNA / Q000235:genetics; D005408:Flagellin / Q000276:immunology / Q000494:pharmacology; D018836:Inflammation Mediators / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D010006:Osteoblasts / Q000276:immunology* / Q000502:physiology; D011550:Pseudomonas aeruginosa / Q000276:immunology / Q000472:pathogenicity; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology*; D012475:Salmonella / Q000276:immunology / Q000472:pathogenicity; D015398:Signal Transduction; D013211:Staphylococcus aureus / Q000276:immunology / Q000472:pathogenicity; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors; D005408:Flagellin; D004247:DNA