Ion-activated in situ gelling systems for sustained ophthalmic delivery of ciprofloxacin hydrochloride.
The poor bioavailability and therapeutic response exhibited by the conventional ophthalmic solutions due to precorneal elimination of the drug may be overcome by the use of in situ gel forming systems that are instilled as drops into the eye and undergo a sol-gel transition in the cul-de-sac. Our present work describes the formulation and evaluation of an ophthalmic delivery system of an antibacterial agent, CPH, based on the concept of ion-activated in situ gelation. Gelrite gellan gum, a novel ophthalmic vehicle that gels in the presence of mono or divalent cations, present in the lacrimal fluid was used alone and in combinations with sodium alginate as the gelling agent. The developed formulations were therapeutically efficacious and provided sustained release of the drug over an 8-hr period in vitro.
Balasubramaniam
J
J
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India.
Pandit
J K
JK
D000464:Alginates / Q000737:chemistry; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry* / Q000494:pharmacology; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000737:chemistry* / Q000494:pharmacology; D002951:Citrates / Q000737:chemistry; D003692:Delayed-Action Preparations; D005260:Female; D005782:Gels; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D066298:In Vitro Techniques; D008297:Male; D009883:Ophthalmic Solutions; D011135:Polysaccharides, Bacterial / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011817:Rabbits; D012212:Rheology; D000077559:Sodium Citrate; D013211:Staphylococcus aureus / Q000187:drug effects
D000464:Alginates; D000890:Anti-Infective Agents; D002951:Citrates; D003692:Delayed-Action Preparations; D005782:Gels; D006603:Hexuronic Acids; D009883:Ophthalmic Solutions; D011135:Polysaccharides, Bacterial; D000077559:Sodium Citrate; D002939:Ciprofloxacin; C048288:gellan gum; D020723:Glucuronic Acid