Medication-induced oesophageal disorders.
Medication-induced oesophageal distress and injury have become increasingly common conditions. First, smooth muscle relaxants may worsen or produce symptoms of pre-existing gastro-oesophageal reflux disease; notable examples include certain calcium antagonists (nifedipine), nitrates, sildenafil, nicotine, theophylline, and substances with antimuscarinic potential. Second, drugs with local toxicity may produce de novo damage including inflammation, strictures, ulcers, and bleeding. Notorious examples are alendronate, certain antibiotics including tetracyclines and clindamycin, all NSAIDs/aspirin, quinidine, potassium chloride, and ferrous sulfate. Cyclooxygenase-2 inhibitors may be devoid of such toxicity, but may damage the mucosa by interfering with regenerative cell proliferation. The galenic formulation can modulate the risk of oesophageal injury. For this reason, medicines containing the same potentially toxic ingredient may be less exchangeable than commonly thought. Diagnostic gold standard is endoscopy. The best treatment is removal of the offending drug and supportive care. Prevention requires a re-appraisal of the drug's indication and adherence to guidelines of optimal drug intake including ingestion in an upright position and swallowing with enough fluid. The clinical relevance of drug-induced oesophageal injury and the feasibility of therapeutic alternatives are individually addressed.
Petersen
Karl-Uwe
KU
Institut für Pharmakologie und Toxikologie, Rheinisch-Westfälische Technische Hochschule Aachen, Wendlingweg 2, 52057 Germany. KarlUwe.Petersen@post.rwth-aachen.de
Jaspersen
Daniel
D
D000284:Administration, Oral; D002214:Capsules; D064420:Drug-Related Side Effects and Adverse Reactions; D004935:Esophageal Diseases / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010600:Pharmacology; D013607:Tablets
D002214:Capsules; D004364:Pharmaceutical Preparations; D013607:Tablets