title: The antioxidant responsive element (ARE) may explain the protective effects of cruciferous vegetables on cancer.
abstract: Research supports the hypothesis that one's diet has a great impact on his or her risk of cancer. Many studies have found that increased fruit and vegetable intake decreases the risk of cancer. Cruciferous vegetables such as broccoli and cauliflower seem to be especially protective against cancer. Most studies show that phytochemicals in crucifers up-regulate many detoxification enzyme systems in the animal that consumes them. Recent reports of the molecular events involved in the activation of a gene promoter called the antioxidant responsive element have begun to provide clues as to how a single substance may induce a battery of many genes.
authors.affiliation: United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: Finley
mesh_terms: D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use*; D019607:Brassicaceae; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D051267:NF-E2-Related Factor 2; D009369:Neoplasms / Q000517:prevention & control*; D015534:Trans-Activators / Q000378:metabolism / Q000494:pharmacology*; D014675:Vegetables
chemical_list: D000975:Antioxidants; D004268:DNA-Binding Proteins; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D015534:Trans-Activators