title: Hypotensive effect of potentiated antibodies to angiotensin II and AT1 receptors.
abstract: Hypotensive activity of ultralow doses of antibodies to angiotensin II and its receptors was studied on adult NISAG rats with hereditary stress-induced arterial hypertension. Antibodies to C-terminal fragment of angiotensin II receptors produced the most pronounced hypotensive effect, which was reproducible after repeated administration. These antibodies decreased systolic blood pressure by 16.40 +/- 0.62 mm Hg. The most rapid hypotensive effect was produced by affinity purified antibodies to angiotensin II: 2 h after administration of these antibodies systolic blood pressure decreased by 12.80 +/- 5.49 mm Hg. Our results indicate that combination treatment with ultralow doses of antibodies to angiotensin II and its receptors hold much promise for the use in clinical practice.
authors.affiliation: Materia Medica Holding Research-and-Production Company, Moscow.
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
authors.forename: A V
authors.initials: AV
authors.lastname: Martyushev
authors.forename: D R
authors.initials: DR
authors.lastname: Kudryashova
authors.forename: A L
authors.initials: AL
authors.lastname: Markel
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
authors.forename: M B
authors.initials: MB
authors.lastname: Shtark
mesh_terms: D000804:Angiotensin II / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000276:immunology / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D006973:Hypertension; D008297:Male; D051381:Rats; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology*
chemical_list: D000906:Antibodies; D000959:Antihypertensive Agents; D044140:Receptor, Angiotensin, Type 1; D000804:Angiotensin II