Phosphorylcholine-endcapped oligomer and block co-oligomer and surface biological reactivity.
Phosphorylcholine (PC)-endcapped oligomer and block co-oligomer were prepared by employing a photoiniferter-based quasi-living polymerization technique. The designed oligomer had a PC polar head group attached to an alkylene chain at one end of the molecule and an oligo(styrene) (oligoST) segment at the other end. In the co-oligomer, an oligo(N,N-dimethylacrylamide) (oligoDMAAm) segment was inserted between both ends of the oligomer mentioned above. Surface coating of these amphiphilic substances, using an appropriate coating procedure, resulted in a very hydrophilic characteristic, suggesting that the oligoST anchored on the substrate and the PC polar head group was exposed to or located on the outer coating layer. Non-cell adhesivity in serum-containing medium was observed, while slightly reduced protein adsorption was observed. Thus, PC-endcapped oligomer and block co-oligomer appear to function as a biocompatible coating.
Matsuda
Takehisa
T
National Cardiovascular Center Research Institute, Department of Bioengineering, 5-7-1, Fujishiro-dai, Suita, Osaka 565-8565, Japan. matsuda@med.kyushu-u.ac.jp
Nagase
Junichi
J
Ghoda
Akane
A
Hirano
Yoshiaki
Y
Kidoaki
Satoru
S
Nakayama
Yasuhide
Y
D040761:Biomimetic Materials / Q000138:chemical synthesis; D004121:Dimethyl Sulfoxide; D009682:Magnetic Resonance Spectroscopy; D010767:Phosphorylcholine / Q000737:chemistry*; D012997:Solvents; D020349:Surface Plasmon Resonance; D013499:Surface Properties
D012997:Solvents; D010767:Phosphorylcholine; D004121:Dimethyl Sulfoxide