Identification of chromosomal imbalances in pancreatic carcinoma using comparative genomic hybridization.
OBJECTIVE
To identify genetic abnormalities in primary pancreatic carcinoma in humans.


METHODS
Comparative genomic hybridization (CGH) was used to investigate genomic imbalances in 27 cases of pancreatic carcinomas. Multiple deletions and gains were observed in all tumor specimens.


RESULTS
Losses affecting chromosomes 9p, 17p, 4q and 6p and gains involving 8q, 7q, 3q and 1q were commonly observed.


CONCLUSIONS
There are multiple regions of chromosomes with changes copy number in pancreatic carcinoma. The altered chromosomal regions may contain several candidate genes which are involved in the development and progress of pancreatic carcinogenesis.
Lin
Moubin
M
Department of Surgery, Huashan Hospital, Shanghai 200040, China. lmbin@cableplus.com.cn
Cai
Duan
D
Luo
Mingde
M
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D010190:Pancreatic Neoplasms / Q000235:genetics*