title: Intravenous indomethacin therapy in infants with a patent ductus arteriosus complicating other congenital heart defects.
abstract: In the present study, 0.2-0.6 mg/kg (0.4+/-0.2, mean +/- standard deviation) indomethacin was administered intravenously to close a patent ductus arteriosus in 13 infants with co-existing congenital heart defects whose ages ranged from 3 to 48 (14+/-14) days. All of them were hemodynamically ductus-independent and symptomatic. Echocardiography demonstrated that the ductus had closed in 8 infants, aged 3-33 (12+/-10) days (responders), but had not closed in 5 infants aged 6-48 (19 +/-19) days (non-responders). There was no significant difference between the responders and non-responders in their age, body weight, minimal diameter of the duct, dose of indomethacin, gestational age, birthweight, or Apgar score. One possible major complication might be associated with indomethacin. However, intravenous indomethacin should be considered prior to surgical ligation as one option for infants with a symptomatic patent ductus arteriosus complicated by other congenital heart defects.
authors.affiliation: Department of Pediatrics, National Cardiovascular Center, Osaka, Japan. kwatanab@hsp.ncvc.go.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Watanabe
authors.forename: Hideshi
authors.initials: H
authors.lastname: Tomita
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ono
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamada
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Kurosaki
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Echigo
mesh_terms: D002317:Cardiovascular Agents / Q000008:administration & dosage*; D004374:Ductus Arteriosus, Patent / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D004452:Echocardiography; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage*; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007275:Injections, Intravenous; D008297:Male; D019233:Retreatment
chemical_list: D002317:Cardiovascular Agents; D007213:Indomethacin