Optimization of experimental conditions for the preparative displacement chromatography of antitumor anthracycline antibiotics on carboxylic sorbents.
The physico-chemical conditions and the limits of the rates of mobile phases are determined when effective regimes of preparative chromatography in the conditions of sharpening the boundaries of chromatographic zones of anthracycline antibiotics are realized. The influence of pH on the equilibrium, kinetics and dynamics of sorption of anthracycline antibiotics (rubomycin, doxorubicin and carminomycin) on the carboxylic sorbents has been studied.
Toshchevikova
A Y
AY
Department of Biopolymers. Institute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoy Pr. 31, St. Petersburg 199 004, Russia.
Ezhova
N M
NM
Pisarev
O A
OA
D000327:Adsorption; D018943:Anthracyclines / Q000032:analysis*; D000900:Anti-Bacterial Agents / Q000032:analysis*; D000970:Antineoplastic Agents / Q000032:analysis*; D002264:Carboxylic Acids / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration
D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D002264:Carboxylic Acids