title: [A case of Duchenne muscular dystrophy showing coagulation cascade activation induced by muscle destruction due to convulsion].
abstract: A male patient with advanced Duchenne muscular dystrophy (DMD) had tonic-clonic convulsion. He showed transient elevations of serum creatine kinase (CK) and plasma D-dimer. Serum CK, ordinarily 122-386 IU/l, was elevated to 9,262 IU/l, while plasma D-dimer, below 66 ng/ml in normal subjects, was at 543 ng/ml, and these levels were significantly correlated. Serum fibrin and fibrinogen degradation products levels were within a normal range. In the present case, acute muscle destruction due to tonic-clonic convulsion was considered to transiently activate a coagulation cascade. Plasma D-dimer elevation is the result of fibrin thrombus and can induce thrombosis, such as a pulmonary embolism. Thrombosis is a serious life-threatening complication of DMD, though the mechanism remains unclear. There were no thrombotic complications in the present patient, however, acute muscle destruction enhances the coagulation and fibrinolysis status in patients with advanced DMD and may be a candidate cause of thrombosis.
authors.affiliation: Department of Neurology, Toneyama National Hospital.
authors.forename: Toshio
authors.initials: T
authors.lastname: Saito
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Matsumura
authors.forename: Sonoko
authors.initials: S
authors.lastname: Nozaki
authors.forename: Susumu
authors.initials: S
authors.lastname: Shinno
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D003402:Creatine Kinase / Q000097:blood; D004830:Epilepsy, Tonic-Clonic / Q000150:complications*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology; D020388:Muscular Dystrophy, Duchenne / Q000097:blood* / Q000473:pathology*
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D003402:Creatine Kinase