Adenocarcinoma arising from a mature cystic teratoma of the testis.
A 52-year-old male diagnosed pathologically with metastatic adenocarcinoma of the skin was referred to our department. Physical examination revealed a right scrotal mass the size of child's head and several skin tumors. Right high orchiectomy and resection of skin tumors were performed. Histopathological examination revealed a well-differentiated, mucinous adenocarcinoma originating from the gastrointestinal epithelium in a mature cystic teratoma (dermoid cyst) of the testis and metastatic mucinous adenocarcinoma of the skin. We made a diagnosis of teratoma with malignant transformation (TMT) of the testis. Combination chemotherapy with low-dose cisplatin/5'-deoxy-5-fluorouridine (CDDP/5'-DFUR) was initiated, but the patient died 8 months after orchiectomy. At autopsy, similar mucinous adenocarcinoma of the testis and the skin were observed at the metastatic sites.
Kasai
Toshinori
T
Department of Urology, Tokushima Red Cross Hospital, Tokushima, Japan. nisseki@orange.ocn.ne.jp
Moriyama
Kazumichi
K
Tsuji
Masahito
M
Uema
Kenzo
K
Sakurai
Noritsugu
N
Fujii
Yoshiyuki
Y
D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery; D003884:Dermoid Cyst / Q000175:diagnosis* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D012878:Skin Neoplasms / Q000556:secondary*; D013724:Teratoma / Q000175:diagnosis* / Q000601:surgery; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000601:surgery