Reaction of 2-polyfluoroalkylchromones with 1,3,3-trimethyl-3,4-dihydroisoquinolines and methylketimines as a direct route to zwitterionic axially chiral 6,7-dihydrobenzo[a]quinolizinium derivatives and 2,6-diaryl-4-polyfluoroalkylpyridines.
[reaction: see text] 2-Polyfluoroalkylchromones react with 1,3,3-trimethyl-3,4-dihydroisoquinolines to give zwitterionic axially chiral 6,7-dihydrobenzo[a]quinolizinium derivatives in high yields. In addition, performing this reaction with aromatic methylketimines is a simple and convenient synthesis of 2,6-diaryl-4-polyfluoroalkylpyridines.
Sosnovskikh
Vyacheslav Ya
VY
Department of Chemistry, Ural State University, 620083 Ekaterinburg, Russia. vyacheslav.sosnovskikh@usu.ru
Usachev
Boris I
BI
Sizov
Aleksei Yu
AY
Vorontsov
Ivan I
II
Shklyaev
Yurii V
YV