title: Controlling chirality.
abstract: New strategies are continually being developed for using enzymes to efficiently catalyse the enantioselective synthesis of chiral non-racemic compounds. Alternatives to asymmetric synthesis or kinetic resolution include dynamic kinetic resolution, deracemisation and enantioconvergent transformations. Moreover, a much greater understanding is being developed of the parameters that can affect the stereochemical outcome of the reaction (e.g. solvent, substrate design, immobilization and directed evolution).
authors.affiliation: School of Chemistry, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, EH9 3JJ, UK. n.j.turner@ed.ac.uk
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Turner
mesh_terms: D002384:Catalysis; D020134:Catalytic Domain / Q000235:genetics; D030562:Databases, Protein; D019020:Directed Molecular Evolution; D004798:Enzymes / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D004800:Enzymes, Immobilized; D007700:Kinetics; D015394:Molecular Structure; D015202:Protein Engineering; D012997:Solvents; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D004798:Enzymes; D004800:Enzymes, Immobilized; D012997:Solvents