title: Crystal structure of trans(3R,2aS)-(-)-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one.
abstract: Chiral, non-racemic hexahydro-oxazolo[3,2-a]pyridin-5-ones are strategic starting materials for the asymmetric synthesis of alkaloids, via the stereoselective C-C bond formation at the position a to the nitrogen atom. The stereoselectivity of this key step is mainly driven by the geometry of the fused rings of the oxazolopyridine moiety. In this work, the synthesis and X-ray structure of trans(3R,2aS)-(-)-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one is reported.
authors.affiliation: Centro de Química del Instituto de Ciencias, BUAP, 14 Sur 6303, CP 72570, Ciudad Universitaria, Puebla, Pue., México.
authors.forename: Luis F
authors.initials: LF
authors.lastname: Roa
authors.forename: Dino
authors.initials: D
authors.lastname: Gnecco
authors.forename: Alberto
authors.initials: A
authors.lastname: Galindo
authors.forename: Jorge
authors.initials: J
authors.lastname: Juárez
authors.forename: Sylvain
authors.initials: S
authors.lastname: Bernès