title: Model studies of the (6-4) photoproduct photoreactivation: synthesis and photosensitized splitting of uracil oxetane adducts.
abstract: Uracil oxetane adducts, which are model compounds for the oxetane intermediates generated during the formation of (6-4) photoproducts or in their photoenzymatic repair, have been synthesized using 1,3-dimethyluracil with carbonyl compounds. On the basis of fluorescence measurements and photolysis experiments, it is demonstrated that the oxetane adducts can be split into the nucleotide base and carbonyl compounds via an electron transfer reaction from photosensitizer. The reaction is more efficient for a stronger electron donor.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei 230026, PR China. qhsong@ustc.edu.cn
authors.forename: Qinhua
authors.initials: Q
authors.lastname: Song
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Hei
authors.forename: Zhixiu
authors.initials: Z
authors.lastname: Xu
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
authors.forename: Qingxiang
authors.initials: Q
authors.lastname: Guo
authors.forename: Qinhua H
authors.initials: QH
authors.lastname: Song
mesh_terms: D018736:DNA Adducts / Q000737:chemistry*; D004260:DNA Repair; D004255:Deoxyribodipyrimidine Photo-Lyase / Q000378:metabolism; D004579:Electron Transport; D004988:Ethers, Cyclic / Q000737:chemistry*; D005453:Fluorescence; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010782:Photolysis; D017319:Photosensitizing Agents / Q000737:chemistry*; D013816:Thermodynamics; D014498:Uracil / Q000737:chemistry*
chemical_list: D018736:DNA Adducts; D004988:Ethers, Cyclic; D017319:Photosensitizing Agents; D014498:Uracil; D004255:Deoxyribodipyrimidine Photo-Lyase; C005287:oxetane