title: Long-range DNA charge transport.
abstract: The stack of base pairs within double helical DNA has been shown to mediate charge transport reactions. Charge transport through DNA can result in chemistry at a distance, yielding oxidative DNA damage at a site remote from the bound oxidant. Since DNA charge transport chemistry depends on coupling within the stacked base pair array, this chemistry is remarkably sensitive to sequence-dependent DNA structure and dynamics. Here, we discuss different features of DNA charge transport chemistry, including applications as well as possible biological consequences and opportunities.
authors.affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Delaney
authors.forename: Jacqueline K
authors.initials: JK
authors.lastname: Barton
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004249:DNA Damage; D008958:Models, Molecular; D009690:Nucleic Acid Conformation
chemical_list: D004247:DNA