The persistence of senescence.
Senescence is a potent anticancer mechanism, representing a barrier that most, if not all, would-be tumor cells must traverse on their path to malignant transformation. In this Perspective, I discuss two recent publications (1, 2) that deal with the durability of senescence. These findings are of interest not only to those who study aging, but to those who study cancer as well.
Sharpless
Norman E
NE
Department of Medicine, Lineberger Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. norman_sharpless@med.unc.edu
D000818:Animals; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000502:physiology; D016161:Genes, Retinoblastoma / Q000502:physiology; D019942:Genes, p16 / Q000502:physiology; D016158:Genes, p53 / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology
D019941:Cyclin-Dependent Kinase Inhibitor p16