Long-term protective immune response elicited by vaccination with an expression genomic library of Toxoplasma gondii.
Immunization of BALB/c mice with an expression genomic library of Toxoplasma gondii induces a Th1-type immune response, with recognition of several T. gondii proteins (21 to 117 kDa) and long-term protective immunity against a lethal challenge. These results support further investigations to achieve a multicomponent anti-T. gondii DNA vaccine.
Fachado
Alberto
A
Laboratory of Autoimmunity and Immunoregulation, Department of Immunology, Oswaldo Cruz Institute, Rio de Janeiro, Brazil.
Rodriguez
Alexandro
A
Molina
Judith
J
Silvério
Jaline C
JC
Marino
Ana P M P
AP
Pinto
Luzia M O
LM
Angel
Sergio O
SO
Infante
Juan F
JF
Traub-Cseko
Yara
Y
Amendoeira
Regina R
RR
Lannes-Vieira
Joseli
J
D000818:Animals; D015870:Gene Expression; D018503:Genome, Protozoan; D015698:Genomic Library; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016052:Protozoan Vaccines / Q000008:administration & dosage* / Q000235:genetics; D018417:Th1 Cells / Q000276:immunology; D013997:Time Factors; D014122:Toxoplasma / Q000235:genetics / Q000276:immunology*; D014124:Toxoplasmosis, Animal / Q000276:immunology / Q000517:prevention & control; D014611:Vaccination; D019444:Vaccines, DNA / Q000235:genetics / Q000494:pharmacology*
D016052:Protozoan Vaccines; D019444:Vaccines, DNA