Effect of Sinomenine on IL-8, IL-6, IL-2 produced by peripheral blood mononuclear cells.
The effect of Sinomenine on IL-8, IL-6, IL-2 and mIL-2R produced by peripheral blood mononuclear cells was investigated by using cell culture, radioimmunoassay and flow cytometry. It was showed that production of IL-8 and mIL-2R was inhibited, but the levels of IL-6 were enhanced by Sinomenine. Our results also demonstrated that Sinomenine did not have any effect on the production of IL-2. The study demonstrated that Sinomenine was able to regulate the production of cytokines. This may be one of the mechanisms by which Sinomenine works on rheumatoid arthritis.
Tu
S
S
Department of Traditional Chinese Medicine, Tongji Hospital, Tongji Medical University, Wuhan 430030.
Hu
Y
Y
Lu
F
F
D018501:Antirheumatic Agents / Q000494:pharmacology*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D006801:Humans; D007376:Interleukin-2; D015850:Interleukin-6; D016209:Interleukin-8; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D009019:Morphinans / Q000494:pharmacology*
D018501:Antirheumatic Agents; D007376:Interleukin-2; D015850:Interleukin-6; D016209:Interleukin-8; D009019:Morphinans; C009271:sinomenine