Cytogenetic effects of antibodies to gamma-interferon in ultralow doses.
Single and course administration of ultralow doses of antibodies gamma-interferon did not increase the incidence of cytogenetic abnormalities in bone marrow cells from BALB/c mice and produced no genotoxic effect on Drosophila melanogaster wing cells in the test of somatic mosaicism.
Voronova
O L
OL
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Rogozina
O P
OP
Martyushev
A V
AV
Sergeeva
S A
SA
Epstein
O I
OI
Dygai
A M
AM
Goldberg
E D
ED
D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000633:toxicity*; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000187:drug effects*; D007371:Interferon-gamma / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D014921:Wings, Animal / Q000166:cytology / Q000187:drug effects
D000906:Antibodies; D009153:Mutagens; D007371:Interferon-gamma