title: [Comparative kinetics of 3-hydroxyphenazepam and its metabolism during transdermal and intravenous administration].
abstract: The kinetics of excretion of 2-(14)C-3-hydroxyphenazepam and its metabolites were studied upon a single transdermal and intravenous administration in mice. The main fraction of the total radioactivity (approximately 80%) was eliminated within approximately 84 h upon intravenous injection and within approximately 360 h after transdermal introduction. In the latter case, the ratio of lipophilic and hydrophilic metabolites is modified as well: the former fraction increases by a factor of 1.75, while the latter decreases by a factor of 1.2 as compared to the case of intravenous drug administration.
authors.affiliation: Odessa National University, Odessa, Ukraine.
authors.forename: V B
authors.initials: VB
authors.lastname: Larionov
authors.forename: N Ia
authors.initials: NIa
authors.lastname: Golovenko
authors.forename: I A
authors.initials: IA
authors.lastname: Kravchenko
authors.forename: A I
authors.initials: AI
authors.lastname: Aleksandrova
authors.forename: N V
authors.initials: NV
authors.lastname: Ovcharenko
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D013693:Temazepam / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000652:urine*
chemical_list: D013693:Temazepam