[Expression of proliferating cell nucleus antigen and nm23 protein and their relation with metastasis in hepatocellular carcinoma].
OBJECTIVE
To investigate the expression of proliferating cell nucleus antigen (PCNA) and nm23 protein in hepatocellular carcinoma (HCC) and their relation with metastasis.


METHODS
The expression of PCNA and nm23 protein in 56 HCCs were detected by the immunohistochemical technique.


RESULTS
Of the 56 HCCs, the expression strength of PCNA and nm23 protein were significantly related to the differentiation degree of HCC: the poorer the differentiation of HCC, the stronger the PCNA expression, and the weaker the nm23 protein expression. The correlation analysis indicated that the strength of the PCNA expression was negatively related to that of nm23 (P < 0.01). The intensity of PCNA expression in HCCs with metastasis was significantly higher than that in HCCs without metastasis (P < 0.01), which was inverse with nm23 protein (P < 0.01).


CONCLUSIONS
The level of PCNA and nm23 protein may reflect the differentiation degree and metastasis potential of HCC, and may be one of the useful parameters for judging prognosis of HCC.
Luo
Hong-ying
HY
Department of Pathology, Xiangya School of Medicine, Central South University, Changsha 410078, China.
Wang
Hai-cheng
HC
Feng
De-yun
DY
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D054778:NM23 Nucleoside Diphosphate Kinases; D009362:Neoplasm Metastasis; D009701:Nucleoside-Diphosphate Kinase; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*
D014408:Biomarkers, Tumor; D054778:NM23 Nucleoside Diphosphate Kinases; D018809:Proliferating Cell Nuclear Antigen; D011506:Proteins; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase