Late onset of tacrolimus-related posterior leukoencephalopathy after living donor liver transplantation.
Neurotoxicity is a well-known side effect of tacrolimus-based immunosuppression after liver transplantation. Until now, only 31 cases of immunosuppression-associated leukoencephalopathy in liver transplant recipients reported in the literature are related to tacrolimus therapy. We report a patient who developed a posterior leukoencephalopathy syndrome, secondary to tacrolimus-based immunosuppression, after living donor liver transplantation. The special features of this case are the sudden and late onset of neurologic symptoms, a persistent comatose state, and increased signal intensity in follow-up MRI.
Frühauf
Nils R
NR
Department of General- and Transplant Surgery, University of Essen, Germany. nils.fruehauf@uni-essen.de
Koeppen Dagger
Susanne
S
Saner
Fuat H
FH
Egelhof Dagger
Thomas
T
Stavrou
Gregor
G
Nadalin
Silvio
S
Broelsch
Christoph E
CE
D003128:Coma / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000209:etiology* / Q000473:pathology; D016031:Liver Transplantation; D019520:Living Donors; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011183:Postoperative Complications; D016559:Tacrolimus / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D016559:Tacrolimus