[Effects of yanlieping formula on mice with chronic nonbacterial prostatitis].
OBJECTIVE
To study the mechanism of Yanlieping Formula in treating chronic nonbacterial prostatitis.


METHODS
Thirty-two C57BL/6 mice were divided into Chinese Traditional Medicine group(Yanlieping group, 10 mice), treatment control group(Cernilton group, 10 mice), model group(6 mice) and normal group(6 mice). The animal model was created by using immunologic adjuvant, and Yanlieping (0.84 g per mouse), Cernilton (7.5 mg per mouse), distilled water(1.05 ml per mouse) and distilled water (0.5 ml per mouse) were respectively administered to the four groups every day for one month. The prostate weight, pathological changes, TNF-alpha and IL-2 in serum were observed.


RESULTS
The prostate weight in Yanlieping group and Cernilton group became significantly lower than in the model group(P < 0.05). Pathologic sign of chronic inflammation became better significantly(Yanlieping group showed more significant improvement). The expression of IL-2 in Yanlieping group and Cernilton group were downregulated significantly. And the expression of TNF-alpha in Yianlieping group was higher than that of the model group and the normal group (P < 0.05).


CONCLUSIONS
The mechanism of Yanlieping Formula in treating chronic prostatitis may lie in the max urethral close pressure reduction, anti-inflammation, local blood circulation improvement.
Xue
Ci-Min
CM
Chinese Traditional Surgery Department, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China.
Zhu
Qi
Q
Xu
Zhao-Dong
ZD
D000818:Animals; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007376:Interleukin-2 / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D011467:Prostate / Q000473:pathology; D011472:Prostatitis / Q000188:drug therapy* / Q000473:pathology; D012434:Secale; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; C010070:cernilton