title: Empty follicle syndrome in two sisters with three cycles: case report.
abstract: Empty follicle syndrome (EFS) is characterized by a lack of retrieved oocytes in the presence of multiple follicle development, in both natural and stimulated cycles. The aim of the present case report is to point out the possibility of genetic factors that could be responsible for some occurrences of EFS. Two sisters with moderate deafness underwent controlled ovarian hyperstimulation and IVF/ICSI cycles at the same centre. During all three cycles there were normal follicular development, estradiol levels and bio-available hCG plasma levels, but no oocytes and cumulus-corona complexes were retrieved, despite second hCG injections. These cases may represent an inherited condition of EFS with hearing loss with genetic factors affecting both the aetiology of EFS and the hearing loss.
authors.affiliation: Centrum Clinic, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Ankara, Turkey 06700. gogsenonalan@yahoo.com
authors.forename: Gögsen
authors.initials: G
authors.lastname: Onalan
authors.forename: Recai
authors.initials: R
authors.lastname: Pabuçcu
authors.forename: Reside
authors.initials: R
authors.lastname: Onalan
authors.forename: Serdar
authors.initials: S
authors.lastname: Ceylaner
authors.forename: Belgin
authors.initials: B
authors.lastname: Selam
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro; D006319:Hearing Loss, Sensorineural / Q000235:genetics; D006801:Humans; D009865:Oocytes; D010049:Ovarian Diseases / Q000235:genetics* / Q000503:physiopathology*; D006080:Ovarian Follicle; D019233:Retreatment; D016879:Salvage Therapy; D020554:Sperm Injections, Intracytoplasmic; D013577:Syndrome; D020858:Tissue and Organ Harvesting
chemical_list: D006063:Chorionic Gonadotropin