Effect of baseline vasodilation on adrenergic reactions of systemic hemodynamics.
Systemic vasodilation produced by sodium nitroprusside in various concentrations and accompanied by a decrease in baseline blood pressure was followed by progressive reduction in pressor responses to alpha-adrenoceptor agonist phenylephrine (mesatone) in rats. In a blood pressure range of below the physiological level (80-100 mm Hg), a positive linear correlation was revealed between the decrease in baseline blood pressure and pressor effect of phenylephrine.
Osadchii
L I
LI
Laboratory of Blood Circulation Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. tch@infran.ru
Balueva
T V
TV
Sergeev
I V
IV
D000316:Adrenergic alpha-Agonists / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology*; D008297:Male; D020030:Nitric Oxide Donors / Q000378:metabolism; D009599:Nitroprusside / Q000378:metabolism; D010656:Phenylephrine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D012044:Regression Analysis; D014662:Vasoconstrictor Agents / Q000378:metabolism; D014664:Vasodilation / Q000502:physiology*; D014665:Vasodilator Agents / Q000378:metabolism
D000316:Adrenergic alpha-Agonists; D020030:Nitric Oxide Donors; D011942:Receptors, Adrenergic, alpha; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D009599:Nitroprusside; D010656:Phenylephrine