Direct lactonization of alkenols via osmium tetroxide-mediated oxidative cleavage.
[reaction: see text] A highly efficient, mild, and simple protocol is presented for the tandem OsO(4)-mediated oxidative cleavage/oxidative lactonization of alkenols to lactones. The protocol couples the OsO(4)-catalyzed oxidative cleavage of olefins with Oxone as the co-oxidant with the direct oxidation of aldehydes in alcoholic solvents to their corresponding esters.
Schomaker
Jennifer M
JM
Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
Travis
Benjamin R
BR
Borhan
Babak
B