Highly practical and enantioselective cu-catalyzed conjugate addition of alkylzinc reagents to cyclic enones at ambient temperature.
[reaction: see text] A new ligand for Cu-catalyzed enantioselective additions of dialkylzincs to cyclic enones has been developed. In addition to providing good to excellent enantioselectivities with a range of cyclic enones and dialkylzincs, the ligand has several notworthy features: it can be readily prepared in just two steps, is an air-stable crystalline solid, and provides optimal performance at ambient temperature.
Krauss
Isaac J
IJ
Department of Chemistry, Columbia University, New York, New York 10027, USA.
Leighton
James L
JL