Potentiation of penile erection and yawning responses to apomorphine by cannabinoid receptor antagonist in rats.
The effect of systemic administration of the cannabinoid antagonist SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxyamide) on penile erection and yawning induced by apomorphine was investigated in rats. SR 141716A (2 mg/kg, i.p.) administered 40 min before apomorphine (40 and 80 microg/kg, s.c.) increased the number of penile erection and yawning responses. The administration of cannabinoid agonist Delta9-tetrahydrocannabinol (1.25 mg/kg, i.p.) 15 min before apomorphine (40 and 80 microg/kg, s.c.) did not affect penile erection, however it decreased yawning. The present results provide additional evidence that cannabinoid agonists interfere with dopaminergic systems and that SR 141716A together with a dopaminergic agonist could be useful to potentiate dopaminergic activity.
da Silva
George E
GE
Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, UFSC, Florianopolis, SC, Brazil.
Fernandes
Marcelo S
MS
Takahashi
Reinaldo N
RN
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D063387:Cannabinoid Receptor Antagonists; D002186:Cannabinoids / Q000378:metabolism* / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D018491:Dopamine Agonists / Q000494:pharmacology; D013759:Dronabinol / Q000494:pharmacology; D004357:Drug Synergism; D008297:Male; D009434:Neural Pathways / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010410:Penile Erection / Q000187:drug effects* / Q000502:physiology; D010880:Piperidines / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D043882:Receptors, Cannabinoid / Q000378:metabolism; D000077285:Rimonabant; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology; D015000:Yawning / Q000187:drug effects* / Q000502:physiology
D063387:Cannabinoid Receptor Antagonists; D002186:Cannabinoids; D018491:Dopamine Agonists; D010880:Piperidines; D011720:Pyrazoles; D043882:Receptors, Cannabinoid; D013759:Dronabinol; D001058:Apomorphine; D000077285:Rimonabant; D004298:Dopamine