Relations of blood pressure to angiotensinogen gene T174M polymorphism and alcohol intake.
To clarify the interactive effects of alcohol intake and angiotensinogen gene codon 174 (T174M) polymorphisms on blood pressure in Japanese male workers. On the basis of data from health examinations, nutrition survey and T174M genotype analysis conducted for 185 Japanese male workers at 2000, the prevalence of high-normal blood pressure (HNBP) and hypertension were compared between the four subgroups crossed by two T174M genotype categories ('TT' type, and 'TM or MM' type) and two alcohol intake categories (less than 13.7 g per day, and 13.7 g or more per day). Furthermore, for 95 subjects who had been normotensive at 1998 among them, risk of development into HNBP or hypertension at 2000 were compared across the four subgroups. The findings showed that the HNBP prevalence adjusted for age, body mass index, smoking habits and sodium intake in 2000 was significantly (p=0.03) greater in 'TM or MM' type (57.9%) than in 'TT' type (24.9%) in subjects with 13.7 g or more of daily alcohol intake, whereas no difference in this parameter was found between the two genotypes in those with less than 13.7 g of daily alcohol intake (18.2% and 18.3%, respectively). The risk for development into HNBP at 2000 was also greatest in 'TM or MM' type with 13.7 g or more of daily alcohol intake among the four subgroups, although there were not significant differences between the four subgroups. The prevalence of hypertension or development risk for hypertension did not significantly differ between the four subgroups. Therefore, it can be seen that alcohol drinking might be specifically associated with the HNBP in M allele carriers of angiotensinogen gene T174M polymorphism.
Takashima
Yutaka
Y
Department of Public Health, Kyorin University School of Medicine, Mitaka, Tokyo, Japan. yutakat@kyorin-u.ac.jp
Kokaze
Akatsuki
A
Matsunaga
Naomi
N
Yoshida
Masao
M
Sekiguchi
Kanako
K
Sekine
Yasuko
Y
Sumiya
Yu
Y
D000428:Alcohol Drinking / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000235:genetics*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000502:physiology*; D015995:Prevalence; D012016:Reference Values; D018570:Risk Assessment
D000959:Antihypertensive Agents; D000808:Angiotensinogen