title: Intramural plasminogen activator inhibitor type-1 and coronary atherosclerosis.
abstract: Altered expression of plasminogen activator inhibitor type-1 in vessel walls, reviewed here, might affect coronary atherogenesis. Upregulation might exacerbate vasculopathy by potentiating thrombosis and by inhibiting vascular smooth muscle cell migration, resulting in attenuation of thickness of elaborated fibrous caps implicated in the vulnerability of atheroma to rupture.
authors.affiliation: Department of Medicine, University of Vermont, Burlington, USA. Burt.sobel@vtmednet.org
authors.forename: Burton E
authors.initials: BE
authors.lastname: Sobel
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Taatjes
authors.forename: David J
authors.initials: DJ
authors.lastname: Schneider
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000378:metabolism*; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology; D007333:Insulin Resistance / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*; D017539:Tunica Intima / Q000378:metabolism
chemical_list: D007328:Insulin; D017395:Plasminogen Activator Inhibitor 1