title: Simultaneous analyses of hypoglycemic agents and C-peptide are essential in a homicide case with the combined dosing insulin and insulin-releasing drug.
abstract: A 5-year-old girl was given a sulfonylurea hypoglycemic agent, 25 mg of glibenclamide (ten tablets of Euglucon) with two benzodiazepine drugs, 2 mg of estazoram and 0.75 mg of triazolam (one tablet of Eurodin and three tablets of Halcion), by her 37-year-old pharmacist father and then injected with 70 units of insulin (NovoLet 40R). She died several hours after the injection of insulin. Autopsy was carried out 12 h after the death. A glibenclamide level of 103 ng/ml was detected in the serum collected from the heart at autopsy. The serum insulin and C-peptide concentrations were 295 microU/ml and 0.5 ng/ml, respectively. The high level of insulin and the low level of C-peptide indicated that most of the serum insulin was exogenous. The determination of the serum C-peptide concentration was useful to the diagnosis of hypoglycemia caused by exogenous insulin even in the case of co-administration with an endogenous-insulin-releasing agent.
authors.affiliation: Department of Legal Medicine, Asahikawa Medical College, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Uezono
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shiono
authors.forename: Keiko
authors.initials: K
authors.lastname: Shimizu
authors.forename: Kento
authors.initials: K
authors.lastname: Ogawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Saito
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Yoshida
authors.forename: Hajime
authors.initials: H
authors.lastname: Mizukami
authors.forename: Kazuo
authors.initials: K
authors.lastname: Matsubara