title: Activity of telithromycin compared with seven other agents against 1039 Streptococcus pyogenes pediatric isolates from ten centers in central and eastern Europe.
abstract: In total, 1039 pediatric Streptococcus pyogenes isolates from Bulgaria, Croatia, the Czech Republic, Hungary, Latvia, Lithuania, Poland, Romania, Slovakia and Slovenia were studied. All strains were susceptible to penicillin G, levofloxacin, and quinupristin-dalfopristin, 91-100% to telithromycin, and 82-100% to erythromycin, azithromycin, and clarithromycin, and 90-100% to clindamycin. Macrolide resistance occurred mainly in Slovakia (25%), the Czech Republic (17.3%), and Croatia (15.8%). Overall, 9.7% of S. pyogenes isolates were erythromycin resistant due to erm(B)- or erm(A)-encoded methylases (72.3%) or to a mef(A)-encoded efflux pump (25.7%). One strain had alterations of both 23S rRNA (A2058G Escherichia coli numbering) and ribosomal protein L22 (G95D).
authors.affiliation: Department of Pathology, Hershey Medical Center, 500 University Dr., Hershey, PA 17033, USA.
authors.forename: B
authors.initials: B
authors.lastname: Bozdogan
authors.forename: P C
authors.initials: PC
authors.lastname: Appelbaum
authors.forename: L M
authors.initials: LM
authors.lastname: Kelly
authors.forename: D B
authors.initials: DB
authors.lastname: Hoellman
authors.forename: A
authors.initials: A
authors.lastname: Tambic-Andrasevic
authors.forename: L
authors.initials: L
authors.lastname: Drukalska
authors.forename: W
authors.initials: W
authors.lastname: Hryniewicz
authors.forename: H
authors.initials: H
authors.lastname: Hupkova
authors.forename: M R
authors.initials: MR
authors.lastname: Jacobs
authors.forename: J
authors.initials: J
authors.lastname: Kolman
authors.forename: M
authors.initials: M
authors.lastname: Konkoly-Thege
authors.forename: J
authors.initials: J
authors.lastname: Miciuleviciene
authors.forename: M
authors.initials: M
authors.lastname: Pana
authors.forename: L
authors.initials: L
authors.lastname: Setchanova
authors.forename: J
authors.initials: J
authors.lastname: Trupl
authors.forename: P
authors.initials: P
authors.lastname: Urbaskova
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005060:Europe / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D048628:Ketolides; D018942:Macrolides; D008745:Methylation; D012270:Ribosomes / Q000378:metabolism; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000453:epidemiology; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; C106791:telithromycin