title: Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
abstract: Antifungal bioassay-guided isolation of the ethanol extract of the roots of Pentagonia gigantifolia yielded 6-octadecynoic acid (1) and the new 6-nonadecynoic acid (2). Compounds 1 and 2 inhibited the growth of fluconazole-susceptible and -resistant Candida albicans strains. Their antifungal potencies were comparable to those of amphotericin B and fluconazole. Of particular significance is the low cytotoxicity and specific activity of 1 and 2 against C. albicans.
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA. xli@olemiss.edu
authors.forename: Xing-Cong
authors.initials: XC
authors.lastname: Li
authors.forename: Melissa R
authors.initials: MR
authors.lastname: Jacob
authors.forename: Hala N
authors.initials: HN
authors.lastname: ElSohly
authors.forename: Dale G
authors.initials: DG
authors.lastname: Nagle
authors.forename: Troy J
authors.initials: TJ
authors.lastname: Smillie
authors.forename: Larry A
authors.initials: LA
authors.lastname: Walker
authors.forename: Alice M
authors.initials: AM
authors.lastname: Clark
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015725:Fluconazole / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D008745:Methylation; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010568:Peru; D018517:Plant Roots / Q000737:chemistry; D013107:Sphingolipids
chemical_list: C479851:6-nonadecynoic acid; C479850:6-octadecynoic acid; D000935:Antifungal Agents; D005229:Fatty Acids, Monounsaturated; D013107:Sphingolipids; D000666:Amphotericin B; D015725:Fluconazole