Reactivity studies of 3-alkoxy-7-amino-4-chloroisocoumarins (beta-amyloid peptide inhibitors) versus different classes of amines.
3-Alkoxy-7-amino-4-chloroisocoumarins have been shown to lower the beta-amyloid secretion (a major component of the senile plaques involved in Alzheimer's disease). This paper reports the characterization of new adducts resulting from the reaction between the isocoumarin synthon and different classes of amines. This study allows on the one hand, a better understanding of the biological molecular processes by which such isocoumarin derivatives may interact with enzyme nucleophiles and, on the other hand, brings out the chemical potential of these synthons to generate new polycyclic derivatives.
Bihel
Frédéric
F
INSERM U-382, Developmental Biology Institute of Marseille (CNRS-INSERM-Univ. Méditerranée-AP Marseille), Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, case 907, 13288 Marseille, France.
Faure
Robert
R
Kraus
Jean-Louis
JL
D000588:Amines / Q000737:chemistry*; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry*; D010446:Peptide Fragments / Q000037:antagonists & inhibitors*
D000588:Amines; D016229:Amyloid beta-Peptides; D003374:Coumarins; D010446:Peptide Fragments