[A patient with peritoneal metastasis from gastric cancer who responded to weekly chemotherapy with paclitaxel on the third line and could take meal].
We report a patient with peritoneal metastasis from gastric cancer who responded to weekly chemotherapy with paclitaxel (TXL) as the third line treatment and could take meals for half a year. The patient was a 64-year-old man who underwent total gastrectomy for advanced gastric cancer with peritoneal metastasis. He was first treated with TS-1 as an outpatient treatment; however, tumor markers rose. He could not take meals and had to be hospitalized. CPT-11 was infused on the second line, but due to disease progress, the patient was administered weekly TXL. TXL (70 mg/m2) was infused over 1 hour after short premedication. Administration was continued for 3 weeks followed by 1 week rest. The tumor markers decreased, and he could take meals and was discharged from hospital. The toxic events were leukopenia (grade 2), alopecia (grade 2) and pneumonia (grade 3).
Nakae
Shiro
S
Dept. of Surgery, Saiseikai Nakatsu Hospital.
Urakawa
Tomoaki
T
Yamamoto
Masashi
M
Kinoshita
Hisoka
H
Sainoh
Kazue
K
Kitaura
Tatsuya
T
Takahashi
Tsuyoshi
T
Takao
Shintaro
S
Shiroiwa
Hiroshi
H
Onoyama
Hirohiko
H
Sugihara
Syunichi
S
Toyota
Jo
J
Saitoh
Yoichi
Y
D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000009:adverse effects; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D000077146:Irinotecan; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage* / Q000009:adverse effects; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D017640:Silicates / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000473:pathology*; D014025:Titanium / Q000008:administration & dosage
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D017640:Silicates; C103828:titanium silicide; D000077146:Irinotecan; D014025:Titanium; D017239:Paclitaxel; D002166:Camptothecin