Gamma-pyrone derivatives, kojic acid methyl ethers from a marine-derived fungus Alternaria [correction of Altenaria] sp.
Kojic acid dimethyl ether (1), and the known kojic acid monomethyl ether (2), kojic acid (3) and phomaligol A (4) have been isolated from the organic extract of the broth of the marine-derived fungus Alternaria sp. collected from the surface of the marine green alga Ulva pertusa. The structures were assigned on the basis of comprehensive spectroscopic analyses. Each isolate was tested for its tyrosinase inhibitory activity. Kojic acid (3) was found to have significant tyrosinase inhibitory activity, but compounds 1, 2, and 4 were found to be inactive.
Li
Xifeng
X
Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
Jeong
Jee Hean
JH
Lee
Kang Tae
KT
Rho
Jung Rae
JR
Choi
Hong Dae
HD
Kang
Jung Sook
JS
Son
Byeng Wha
BW
D000528:Alternaria / Q000737:chemistry*; D008738:Methyl Ethers / Q000737:chemistry / Q000302:isolation & purification*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification*; D044445:Ulva / Q000382:microbiology
D008738:Methyl Ethers; D011753:Pyrones; C011890:kojic acid