title: [Results of combined therapy for maxillary sinus squamous cell carcinoma].
abstract: The results of 54 cases of maxillary sinus squamous cell carcinoma treated between 1980 and 2002 were analyzed retrospectively. The T classification according to the 1997 UICC was as follows: 2 with stage T1, 29 with T3, and 23 with T4. Ten patients(18.5%) had lymph node metastases at diagnosis. All patients underwent combined therapy including radiotherapy, surgery, and regional or systemic chemotherapy. Fifteen patients received hyperfractionated twice-daily radiotherapy (1.2 Gy or 1.5 Gy/fraction), and the remaining 39 patients received a conventional once-daily regimen(1.5-2 Gy/fraction). The 5-year overall survival and 5-year disease-free survival for all patients were 56.0% and 46.7%, respectively. The N classification was the only significant prognostic factor for 5-year disease-free survival by univariate analysis (favoring N = 0, p = 0.04). There were no significant differences in other prognostic factors including gender, T classification (T1-3 vs. T4), hyperfractionated radiotherapy (yes vs. no), total dose (BED: < 69 Gy10 vs. > or = 69 Gy10), and intra-arterial chemotherapy(yes vs. no). Although radiation-induced cataract was observed in 9 patients, no other severe late complications developed.
authors.affiliation: Department of Radiologic Technology, School of Health Sciences, Faculty of Medicine, Kyushu University, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Yamada
authors.forename: Shu
authors.initials: S
authors.lastname: Onodera
authors.forename: Katsuya
authors.initials: K
authors.lastname: Yahara
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ohguri
authors.forename: Fumio
authors.initials: F
authors.lastname: Kato
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nomoto
authors.forename: Hajime
authors.initials: H
authors.lastname: Imada
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakata
authors.forename: Hiromi
authors.initials: H
authors.lastname: Terashima
authors.forename: Koji
authors.initials: K
authors.lastname: Kudoh
authors.forename: Masafumi
authors.initials: M
authors.lastname: Yoshida
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D008875:Middle Aged; D011379:Prognosis