Novel therapeutic strategies based on toll-like receptor signaling.
The innate immune system is a critical first line of defense against many microbial, fungal and viral pathogens. Toll-like receptors play a central role in innate immunity, recognizing conserved pathogen-associated molecular patterns and generating signals leading to the initiation of an adaptive immune response. Because of their ability to modulate adaptive immunity, Toll-like receptors represent strategic therapeutic targets for diseases that involve inappropriate adaptive immune responses, such as sepsis, autoimmune disorders, cancer and allergy.
Lawton
Jeffrey A
JA
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0314, USA.
Ghosh
Partho
P
D000818:Animals; D015551:Autoimmunity; D016503:Drug Delivery Systems; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy; D007113:Immunity, Innate; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D008562:Membrane Glycoproteins / Q000187:drug effects* / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000502:physiology; D018805:Sepsis / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D015398:Signal Transduction; D051193:Toll-Like Receptors
D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors