title: Reactivity of tracheal smooth muscles in albino rats with experimental diabetes mellitus treated with a new complex compound of oxovanadium (IV) and isonicotinic acid hydrazide.
abstract: We studied functional properties of tracheal smooth muscle cells in rats with diabetes mellitus. Reactivity of tracheal smooth muscles increased in rats with experimental alloxan-induced diabetes mellitus. A new complex compound of oxovanadium (IV) and isonicotinic acid hydrazide affected reactivity of tracheal smooth muscles in albino rats with experimental type I diabetes mellitus. This new organic vanadium-containing compound reduced contractility of tracheal smooth muscles in rats and potentiated relaxation of smooth muscle cells in the trachea in response to exogenous nitric oxide.
authors.affiliation: Department of Pharmacology, Department of Pathophysiology, Kazan' State Medical University.
authors.forename: R Kh
authors.initials: RKh
authors.lastname: Khafiz'yanova
authors.forename: M M
authors.initials: MM
authors.lastname: Minnebaev
authors.forename: R M
authors.initials: RM
authors.lastname: Gallyamov
authors.forename: R S
authors.initials: RS
authors.lastname: Latypov
authors.forename: A R
authors.initials: AR
authors.lastname: Gosmanov
authors.forename: G N
authors.initials: GN
authors.lastname: Aleeva
mesh_terms: D000496:Alloxan; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D018679:Cholinergic Agonists / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D004338:Drug Combinations; D005260:Female; D007538:Isoniazid / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects* / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D014132:Trachea / Q000033:anatomy & histology / Q000378:metabolism*; D014638:Vanadates / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D018679:Cholinergic Agonists; D004338:Drug Combinations; C075743:oxovanadium IV; D009569:Nitric Oxide; D014638:Vanadates; D000496:Alloxan; D002217:Carbachol; D007538:Isoniazid