Mum, this bud's for you: where do you want it? Roles for Cdc42 in controlling bud site selection in Saccharomyces cerevisiae.
The generation of asymmetric cell shapes is a recurring theme in biology. In budding yeast, one form of cell asymmetry occurs for division and is generated by anisotropic growth of the mother cell to form a daughter cell bud. Previous genetic studies uncovered key roles for the small GTPase Cdc42 in organizing the actin cytoskeleton and vesicle delivery to the site of bud growth, but a recent paper has also raised questions about how control of Cdc42 activity is integrated into a proposed hierarchical regulatory pathway that specifies a unique site of bud formation.
Nelson
W James
WJ
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5435, USA. wjnelson@stanford.edu
D002453:Cell Cycle; D015966:Gene Expression Regulation, Fungal; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D013696:Temperature; D020764:cdc42 GTP-Binding Protein / Q000235:genetics* / Q000502:physiology*
D020764:cdc42 GTP-Binding Protein