RecQ helicases: multiple roles in genome maintenance.
The RecQ helicases are highly conserved in evolution and are required for maintaining genome stability in all organisms. In humans, loss of RecQ helicase function is associated with predisposition to cancer and/or premature ageing. Recent data show that RecQ helicases have several roles during S phase of the cell cycle, ranging from facilitating the resumption of DNA synthesis at sites of replication fork breakdown to resolving structures during the process of homologous recombination.
Khakhar
Rakesh R
RR
Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK OX3 9DS.
Cobb
Jennifer A
JA
Bjergbaek
Lotte
L
Hickson
Ian D
ID
Gasser
Susan M
SM
D000818:Animals; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism*; D016678:Genome; D006801:Humans; D053484:RecQ Helicases; D011995:Recombination, Genetic; D016196:S Phase; D016615:Telomere / Q000235:genetics / Q000378:metabolism
D004265:DNA Helicases; D053484:RecQ Helicases