title: Familial cutis tricolor: a possible example of paradominant inheritance.
abstract: Cutis tricolor is a recently described skin disorder characterized by the coexistence of congenital hyper- and hypopigmented macules adjacent to each other on a background of normal skin. It has been considered to represent an example of didymosis (twin spotting), which is a particular form of loss of heterozygosity. Cutis tricolor may occur as a cutaneous feature of various multisystem birth defects. We report two sisters with cutis tricolor. One of them had, in addition, unilateral hypoplasia of the breast. This familial occurrence of cutis tricolor may best be explained by the concept of paradominant inheritance. 2003.
authors.affiliation: Başkent University Faculty of Medicine, Department of Dermatology, Adana Hospital, 01250 Adana, Turkey. metebaba17@hotmail.com
authors.forename: Mete
authors.initials: M
authors.lastname: Baba
authors.forename: Deniz
authors.initials: D
authors.lastname: Seçkin
authors.forename: Cenk
authors.initials: C
authors.lastname: Akçali
authors.forename: Rudolf
authors.initials: R
authors.lastname: Happle
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000235:genetics; D000293:Adolescent; D001941:Breast Diseases / Q000150:complications / Q000151:congenital / Q000175:diagnosis* / Q000235:genetics; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D010859:Pigmentation Disorders / Q000150:complications / Q000151:congenital / Q000175:diagnosis* / Q000235:genetics; D035781:Siblings