title: General growth mixture modeling for randomized preventive interventions.
abstract: This paper proposes growth mixture modeling to assess intervention effects in longitudinal randomized trials. Growth mixture modeling represents unobserved heterogeneity among the subjects using a finite-mixture random effects model. The methodology allows one to examine the impact of an intervention on subgroups characterized by different types of growth trajectories. Such modeling is informative when examining effects on populations that contain individuals who have normative growth as well as non-normative growth. The analysis identifies subgroup membership and allows theory-based modeling of intervention effects in the different subgroups. An example is presented concerning a randomized intervention in Baltimore public schools aimed at reducing aggressive classroom behavior, where only students who were initially more aggressive showed benefits from the intervention.
authors.affiliation: Graduate School of Education & Information Studies, University of California, Moore Hall, Box 951521, Los Angeles, CA 90095-1521, USA. bmuthen@ucla.edu
authors.forename: Bengt
authors.initials: B
authors.lastname: Muthén
authors.forename: C Hendricks
authors.initials: CH
authors.lastname: Brown
authors.forename: Katherine
authors.initials: K
authors.lastname: Masyn
authors.forename: Booil
authors.initials: B
authors.lastname: Jo
authors.forename: Siek-Toon
authors.initials: ST
authors.lastname: Khoo
authors.forename: Chih-Chien
authors.initials: CC
authors.lastname: Yang
authors.forename: Chen-Pin
authors.initials: CP
authors.lastname: Wang
authors.forename: Sheppard G
authors.initials: SG
authors.lastname: Kellam
authors.forename: John B
authors.initials: JB
authors.lastname: Carlin
authors.forename: Jason
authors.initials: J
authors.lastname: Liao