title: Transsphenoidal hypophysectomy for four dogs with pituitary ACTH-producing adenoma.
abstract: Four dogs diagnosed as pituitary-dependent hyperadrenocorticism were treated with transsphenoidal hypophysectomy and postoperative hormone supplementation therapy. On histological examination of the resected tissues, the tumors were ACTH-producing adenoma of the anterior lobe. Clinical signs such as alopecia and calcinosis cutis, as well as endocrinological abnormalities, were markedly alleviated after surgery. The clinical courses of these 4 dogs suggest that transsphenoidal hypophysectomy may be a useful treatment for pituitary-dependent hyperadrenocorticism.
authors.affiliation: Division of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Animal Science University, Tokyo, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Hara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tagawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Masuda
authors.forename: Toshinori
authors.initials: T
authors.lastname: Sako
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Koyama
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Orima
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Nakamura
authors.forename: Kimimasa
authors.initials: K
authors.lastname: Takahashi
authors.forename: Naoko
authors.initials: N
authors.lastname: Sanno
authors.forename: Akira
authors.initials: A
authors.lastname: Teramoto
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery* / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D004285:Dogs; D005260:Female; D007016:Hypophysectomy / Q000379:methods* / Q000662:veterinary*; D008297:Male; D010902:Pituitary Gland / Q000601:surgery
chemical_list: D000324:Adrenocorticotropic Hormone