[Regulation of oxidative activity of neutrophils by chorionic gonadotropin. The role of female steroid sex hormones].
We studied the effect of the main sex hormone, chorionic gonadotropin, on the production of the active forms of oxygen and nitrogen by human neutrophils and the control of its effects by female steroid sex hormones. Gonadotropin proved to inhibit both total production of oxygen metabolites and NO synthesis by the cells. Gonadotropin-dependent regulation of oxidative activity of the neutrophils is controlled by female steroid sex hormones. At the same time, progesterone completely or partially inhibits the suppressive effects of gonadotropin, while estradiol has antagonistic, sensibilizing, or permissive effect on gonadotropin depending on the dose, incubation conditions, and activation status of the cells.
Kuklina
E M
EM
Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, ul. Goleva 13, Perm, 614081 Russia.
Shirshev
S V
SV
D002478:Cells, Cultured; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006801:Humans; D018375:Neutrophil Activation / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism
D006063:Chorionic Gonadotropin; D012739:Gonadal Steroid Hormones; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D011374:Progesterone; D004958:Estradiol