Preparation and in vitro evaluation of a novel amphiphilic GdPCTA-[12] derivative; a micellar MRI contrast agent.
A novel amphiphilic GdPCTA-[12] derivative has been prepared. The complex formed micelles in aqueous solution with a relatively low CMC, 0.15 mM (25 degrees C). The concentration dependent T1-relaxivity (r1) of the system has been described. The maximum T1-relaxivity, 29.2 s-1 mM-1 (20 MHz, 25 degrees C), was higher than for previously described micellar MRI contrast agents. This high T1-relaxivity is a consequence of the favourable water residence time (tau M) and the fact that the complex is heptadentate allowing two water molecules to coordinate to the gadolinium ion (q = 2).
Hovland
Ragnar
R
Department of Medicinal Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1155, Blindern, N-0318 Oslo, Norway. ragnar.hovland@farmasi.uio.no
Gløgård
Christian
C
Aasen
Arne J
AJ
Klaveness
Jo
J
D003287:Contrast Media / Q000138:chemical synthesis*; D019786:Gadolinium DTPA / Q000138:chemical synthesis*; D008279:Magnetic Resonance Imaging; D008823:Micelles; D012996:Solutions; D013501:Surface-Active Agents / Q000138:chemical synthesis; D014867:Water
D003287:Contrast Media; D008823:Micelles; D012996:Solutions; D013501:Surface-Active Agents; D014867:Water; D019786:Gadolinium DTPA