Evidence for a melanin cell wall component in Pneumocystis carinii.
Fluorescein isothiocyanate-labeled monoclonal antibodies specific for fungal melanin were used in this study to visualize melanin-like components of the Pneumocystis carinii cell wall. A colorimetric enzyme assay confirmed these findings. This is the first report of melanin-like pigments in Pneumocystitis.
Icenhour
Crystal R
CR
Thoracic Diseases Research Unit, Division of Pulmonary, Critical Care and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
Kottom
Theodore J
TJ
Limper
Andrew H
AH
D000818:Animals; D002473:Cell Wall / Q000378:metabolism; D003124:Colorimetry; D005455:Fluorescent Antibody Technique; D008543:Melanins / Q000378:metabolism*; D010860:Pigments, Biological / Q000378:metabolism; D011010:Pneumocystis / Q000302:isolation & purification / Q000378:metabolism*; D011020:Pneumonia, Pneumocystis / Q000382:microbiology; D051381:Rats; D020318:Rats, Long-Evans
D008543:Melanins; D010860:Pigments, Biological