title: The small nucleoid-binding proteins H-NS, HU, and Fis affect hilA expression in Salmonella enterica serovar Typhimurium.
abstract: hilA encodes an activator of Salmonella enterica serovar Typhimurium virulence genes and is transcriptionally modulated by environmental conditions. We show that H-NS represses hilA under low-osmolarity conditions. H-NS, HU, and Fis also appear to affect the derepression of hilA by HilD. Modulation of hilA by counteracting repressing and derepressing mechanisms may allow Salmonella serovar Typhimurium to regulate its virulence genes in response to different situations in vivo.
authors.affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. LS239@cornell.edu
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Schechter
authors.forename: Sumita
authors.initials: S
authors.lastname: Jain
authors.forename: Samina
authors.initials: S
authors.lastname: Akbar
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Lee
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D035021:Factor For Inversion Stimulation Protein / Q000235:genetics / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D009154:Mutation; D012329:RNA, Bacterial / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012486:Salmonella typhimurium / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology*; D013489:Suppression, Genetic; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D014774:Virulence / Q000235:genetics / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D035021:Factor For Inversion Stimulation Protein; C031908:H-NS protein, bacteria; C102236:HilA protein, Salmonella; D012329:RNA, Bacterial; D012333:RNA, Messenger; D015534:Trans-Activators; C040330:histone-like protein HU, bacteria