title: [Effect of hypoxia on respiration system in aging].
abstract: The purpose of the research was to investigate the peculiarities of ventilatory reaction to hypoxia with the elderly and old people. 27 practically healthy young (20-35 years), 24 elderly (60-74 years) and old (older 74 years) people were examined. The influence of hypoxia on the gas exchange was investigated during the respiration of gas mixtures with 17% and 12.5% of oxygen content (during 12 minutes), that corresponds to 1500 m and 4000 m above sea level. The parameters of ventilating function of the lung were determined on the spirograf CT-1M. Oxygen tension in arterial blood (PaO2) was determined with the device "AVL" by "OMNI" (Austria). The curves of ventilating dependence on PaO2 for the young and old people are plotted using the mathematical model. It was shown, that with aging the "steepness" of curve's dependence on the ventilatory answer from the degree of hypoxemia decreases, that testifies to the decrease of chemoreflex sensitivity.
authors.affiliation: Institute of Gerontology AMS of Ukraine, Kiev.
authors.forename: O V
authors.initials: OV
authors.lastname: Korkushko
authors.forename: L A
authors.initials: LA
authors.lastname: Ivanov
authors.forename: M D
authors.initials: MD
authors.lastname: Chebotar'ov
authors.forename: A V
authors.initials: AV
authors.lastname: Pysaruk
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000503:physiopathology*; D008875:Middle Aged; D008954:Models, Biological; D010092:Oximetry; D010100:Oxygen / Q000097:blood; D012123:Pulmonary Ventilation / Q000502:physiology*; D013147:Spirometry
chemical_list: D010100:Oxygen