title: Immunotropic effects of potentiated antibodies to human interferon-gamma.
abstract: We studied immunotropic properties of antibodies to human interferon-gamma in homeopathic doses. The effects of these antibodies on the ratio between the counts of T helper (CD4+) and T suppressor cells (CD8+), production of interleukin-1 and interleukin-2, and functional activity of natural killer cells were evaluated. Potentiated antibodies slightly decreased the number of CD8+ cells in the spleen of experimental animals. After the addition to cultured human mononuclear cells the preparation produced a moderate comitogenic effect, stimulated proliferation of T and B lymphocytes, increased spontaneous and induced production of interleukin-1, and enhanced functional activity of natural killer cells (under certain conditions).
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
authors.forename: E Yu
authors.initials: EY
authors.lastname: Sherstoboev
authors.forename: N M
authors.initials: NM
authors.lastname: Masnaya
authors.forename: A A
authors.initials: AA
authors.lastname: Churin
authors.forename: O S
authors.initials: OS
authors.lastname: Borsuk
authors.forename: A V
authors.initials: AV
authors.lastname: Martyushev
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: E D
authors.initials: ED
authors.lastname: Goldberg
mesh_terms: D000328:Adult; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D007371:Interferon-gamma / Q000276:immunology*; D007375:Interleukin-1 / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D007694:Killer Cells, Natural / Q000187:drug effects / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D055815:Young Adult
chemical_list: D000906:Antibodies; D007155:Immunologic Factors; D007375:Interleukin-1; D007376:Interleukin-2; D007371:Interferon-gamma