title: Premorbid functioning in early-onset psychotic disorders.
abstract: OBJECTIVE
  To examine the premorbid characteristics of youths with early-onset psychotic disorders.
  
  
  METHODS
  Subjects with early-onset psychotic disorders received an extensive diagnostic evaluation upon entry into the study, including a historic review of premorbid functioning using the Premorbid Adjustment Scale.
  
  
  RESULTS
  Youths with schizophrenia (n = 27), bipolar disorder (n = 22), and psychosis not otherwise specified (NOS) (n = 20) were included. High rates of premorbid behavioral problems and academic difficulties were noted across all subjects. Youths with schizophrenia had higher rates of premorbid social withdrawal and global impairment. They also tended to have fewer friends. The psychosis NOS group had significantly higher rates of abuse histories and posttraumatic stress disorder.
  
  
  CONCLUSIONS
  Premorbid abnormalities are common features of early-onset psychotic disorders. The social withdrawal and peer problems specific to youths with schizophrenia likely represent early manifestations of negative symptoms. The abuse histories in the psychosis NOS group may explain the atypical nature of their reported psychotic symptoms, which in many cases are likely posttraumatic phenomena.
authors.affiliation: Department of Psychiatry, University of Washington, Seattle 98195, USA. drjack@u.washington.edu
authors.forename: Jon
authors.initials: J
authors.lastname: McClellan
authors.forename: David
authors.initials: D
authors.lastname: Breiger
authors.forename: Chris
authors.initials: C
authors.lastname: McCurry
authors.forename: Stefanie A
authors.initials: SA
authors.lastname: Hlastala
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D017668:Age of Onset; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000523:psychology; D012737:Sex Factors; D013997:Time Factors