Proinflammatory effects of exogenously administered IL-10 in experimental autoimmune orchitis.
We studied the effects of exogenously administered recombinant murine interleukin (IL)-10 on the development of experimental autoimmune orchitis (EAO) in C3H/He mice. IL-10 significantly augments histological signs of EAO when administered for 6 consecutive days from days 15 to 20 after primary immunisations with testicular germ cells. These data demonstrate that IL-10, in addition to its well-known antiinflammatory property, also has proinflammatory functions capable of up-regulating testicular immunoinflammatory processes in vivo.
Kaneko
Tetsushi
T
Department of Anatomy, Tokyo Medical University, Shinjuku 6-1-1, Shinjuku-ku Tokyo, Japan.
Itoh
Masahiro
M
Nakamura
Yoichi
Y
Iimura
Akira
A
Hayashi
Shogo
S
Takahashi
Kodo
K
Stivala
Franca
F
Bendtzen
Klaus
K
Nicoletti
Ferdinando
F
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D018450:Disease Progression; D006968:Hypersensitivity, Delayed / Q000276:immunology; D016753:Interleukin-10 / Q000633:toxicity*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009920:Orchitis / Q000276:immunology* / Q000473:pathology; D013737:Testis / Q000187:drug effects / Q000473:pathology
D016753:Interleukin-10