[Focal adhesion kinase (FAK), a multifunctional protein].
Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase localized to regions called focal adhesions. Many stimuli can induce tyrosine phosphorylation and activation of FAK, including integrins and growth factors. The major site of autophosphorylation, tyrosine 397, is a docking site for the SH2 domains of Src family proteins. The other sites of phosphorylation are phosphorylated by Src kinases. Phosphorylated FAK binds proteins of focal adhesion and can activate them directly or indirectly by phosphorylation. These activated proteins forming the FAK complex facilitate the generation of downstream signals necessary to regulate cell functions, like motility, survival and proliferation. Dysregulation of FAK could participate in the development of cancer. This review will focus upon the mechanisms by which FAK transmits biochemical signals and elicits biological effects.
Cornillon
Jérôme
J
Laboratoire Mort Cellulaire et Néoplasie, Faculté de médecine J. Lisfranc de Saint-Etienne, 15, rue Ambroise Paré, 42023 Saint-Etienne, France. jerome_cornillon@hotmail.com
Campos
Lydia
L
Guyotat
Denis
D
D000818:Animals; D002448:Cell Adhesion; D002455:Cell Division; D002465:Cell Movement; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D016023:Integrins; D011505:Protein-Tyrosine Kinases / Q000494:pharmacology*; D015398:Signal Transduction
D006133:Growth Substances; D016023:Integrins; D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496050:PTK2 protein, human