title: Use of various microdosimetric models for the prediction of radon induced damage in human lungs.
abstract: Exposure to radon and radon decay products in some residential areas and at workplaces constitutes one of the greatest risks from natural sources of ionising radiation. Recently, increasing attention has been paid to the precise estimations of this health risk by numerous models. The compartmental model published in ICRP Publication 66 (HRTM) has been used for calculating alpha activity concentration in human lung. Energy deposition in the tissue was calculated by the Bethe-Bloch equation. The aim of this study was to check the performance and to compare the reliability of the microdosimetric models. In this work different thicknesses of mucus in the cases of non-smokers and smokers has been considered. Transformed cells were considered as the radiation risk parameters. The radiation risk evaluation for different exposure levels was based on homogeneous and heterogeneous distributions of target cells. The results of application of these procedures were compared with the epidemiological study of Czechoslovakian uranium miners.
authors.affiliation: Faculty of Mathematics and Physics, Comenius University, Mlynska dolina F1, 842 48 Bratislava, Slovak Republic. bohm@fmph.uniba.sk
authors.forename: R
authors.initials: R
authors.lastname: Böhm
authors.forename: D
authors.initials: D
authors.lastname: Nikodémová
authors.forename: K
authors.initials: K
authors.lastname: Holý
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects; D003198:Computer Simulation; D018153:Czech Republic / Q000453:epidemiology; D004307:Dose-Response Relationship, Radiation; D004785:Environmental Pollutants / Q000009:adverse effects; D006801:Humans; D018499:Linear Energy Transfer; D008168:Lung / Q000378:metabolism* / Q000528:radiation effects; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology*; D008906:Mining / Q000706:statistics & numerical data; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology*; D011829:Radiation Dosage; D011835:Radiation Protection / Q000379:methods; D011874:Radiometry; D011886:Radon / Q000032:analysis* / Q000493:pharmacokinetics* / Q000633:toxicity; D012062:Relative Biological Effectiveness; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012680:Sensitivity and Specificity; D012907:Smoking / Q000453:epidemiology
chemical_list: D004785:Environmental Pollutants; D011886:Radon