10-Methoxydihydrofuscin, fuscinarin, and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum.
Two new compounds, 10-methoxydihydrofuscin (1) and fuscinarin (2), and one known compound, fuscin (3), have been isolated from the soil fungus Oidiodendron griseum. These compounds were found to compete effectively with macrophage inflammatory protein (MIP)-1 alpha for binding to human CCR5, an important anti HIV-1 target that interferes with HIV entry into cells. The structures of these compounds were elucidated by spectroscopic methods.
Yoganathan
K
K
MerLion Pharmaceuticals, 59A Science Park Drive, The Fleming, Singapore Science Park, Singapore 118240.
Rossant
Christine
C
Ng
Siewbee
S
Huang
Yicun
Y
Butler
Mark S
MS
Buss
Antony D
AD
D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D065100:CCR5 Receptor Antagonists; D054407:Chemokine CCL4; D005658:Fungi / Q000737:chemistry*; D015497:HIV-1 / Q000276:immunology* / Q000502:physiology; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D019402:Macrophage Inflammatory Proteins / Q000378:metabolism*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
C479848:10-methoxydihydrofuscin; D001578:Benzopyrans; D065100:CCR5 Receptor Antagonists; D054407:Chemokine CCL4; D006575:Heterocyclic Compounds, 3-Ring; D019402:Macrophage Inflammatory Proteins; C479849:fuscinarin; C100026:fuscin