[Observation on the effects of urapidil on hemodynamics in heart dysfunction dogs by thoracic electrical bioimpedance].
OBJECTIVE
To observe the effects of urapidil on hemodynamics in heart dysfunction dogs by thoracic electrical bioimpedance.


METHODS
Sixteen health anesthesia dogs were taken pentobarbital till their hearts dysfunction. Then 10 dogs were taken urapidil injection (4 microg x kg(-1) x min(-1)) and 6 dogs were taken the same doses of normal saline, and heart rate (HR), stroke volume (SV), cardiac output (CO), pre-ejection period (PEP), left ventricular ejection time (LVET), systole time ratio (STR), isovolumic relaxation time (IRT), pulmonary capillary wedge pressure (PCWP), left ventricular end-diastolic pressure (LVEDP), total peripheral resistance (TPR), stroke work (SW) and cardiac work (CW) were continuously monitored by non-invasive hemodynamic monitoring system. Data were recorded at 15 minutes, 30 minutes, 60 minutes, 90 minutes and 120 minutes after dysfunction.


RESULTS
Compared to the group of normal saline, urapidil could increase CO and SV, shorten PEP and STR, decrease PCWP, LVEDP and TPR, increase SW and CW.


CONCLUSIONS
The change of hemodynamics in heart dysfunction dogs can be observed, non-invasively and accurately, by thoracic electrical bioimpedance. Urapidil can obviously decrease preload and postload of heart, increase CO and myocardial contract potentiality, and improve heart function.
Chen
Wei
W
Department of Emergency, General Hospital of People's Liberation Army, Beijing 100853, China.
Shen
Hong
H
D058668:Adrenergic alpha-1 Receptor Antagonists / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D002302:Cardiac Output; D009202:Cardiomyopathies / Q000188:drug therapy*; D004285:Dogs; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D008991:Monitoring, Physiologic; D010879:Piperazines / Q000494:pharmacology*; D013318:Stroke Volume; D014655:Vascular Resistance
D058668:Adrenergic alpha-1 Receptor Antagonists; D010879:Piperazines; C015568:urapidil