title: Paramacular coloboma.
abstract: BACKGROUND
  Paramacular coloboma (plural: colobomata) is a solitary oval football or torpedo-shaped chorioretinal lesion located temporal to the fovea in one or both eyes. Previous case reports have speculated varying etiology, but few have justified its pathognomonic shape and location. We believe it to be congenital in nature and caused by incomplete differentiation of the arcuate bundles along the horizontal raphe in development of the macular architecture. Associated ocular findings may include blepharophimosis, situs inversus, or other anomalous retinal vascular patterns.
  
  
  METHODS
  Three cases of asymptomatic unilateral paramacular colobomata are presented. In each case, a single oval chorioretinal lesion temporal to the macula was found during routine examination. Visual acuity and Humphrey threshold visual field testing were normal with no other associated congenital, systemic, or ocular abnormalities. Because the lesion is nonprogressive, these patients can be followed on an annual basis.
  
  
  CONCLUSIONS
  Due to their anatomical origin, paramacular colobomata are always located temporal to the macula and have an oval football-shaped appearance. Visual acuity and visual field testing are usually normal, although highly observant patients may be aware of a mild scotoma. Differential diagnosis is important because the clinical appearance can be similar to acquired conditions, most notably age-related macular degeneration and presumed ocular histoplasmosis syndrome.
authors.affiliation: VA Greater Los Angeles Healthcare System, Santa Barbara Community-Based Outpatient Clinic, Santa Barbara, CA, USA.
authors.forename: Debi
authors.initials: D
authors.lastname: Pian
authors.forename: Steven
authors.initials: S
authors.lastname: Ferrucci
authors.forename: Sheila F
authors.initials: SF
authors.lastname: Anderson
authors.forename: Connie
authors.initials: C
authors.lastname: Wu
mesh_terms: D003103:Coloboma / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D003937:Diagnosis, Differential; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D008875:Middle Aged