title: Prevalence of soy protein hypersensitivity in cow's milk protein-sensitive children in Korea.
abstract: This study was aimed to evaluate the prevalence of soy protein hypersensitivity in cow's milk protein-sensitive children in Korea. A total of 1,363 patients with atopic dermatitis, urticaria, enterocolitis syndrome, bronchial asthma or allergic rhinitis were recruited. First, we estimated the prevalence of sensitization to soy in children sensitized to cow's milk. Specific IgE levels > 0.7 kU/L by CAP assay were considered positive. Next, the prevalence of soy allergy in cow's milk allergy (CMA) patients was investigated. Those children whose parents agreed to participate the open challenge test with soy had a convincing history of allergic reactions elicited by cow's milk and these symptoms were relieved by elimination. All of them had negative soy-specific IgE. Patients with positive soy-specific IgE accounted for 18.3% of 224 children sensitized to cow's milk protein. The prevalence of sensitization to soy decreased with age (36.8% in the first year of life, 16.4% in the second year, and 13.7% in the third year). Of 21 CMA patients, 42.9% (n=9) were determined to have soy allergy (mean age 10.3 months). Our results suggest that soy protein formula should be carefully used as a substitute for cow's milk in CMA patients, especially during infancy.
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Kang-Mo
authors.initials: KM
authors.lastname: Ahn
authors.forename: Young-Shin
authors.initials: YS
authors.lastname: Han
authors.forename: Seung-Yeon
authors.initials: SY
authors.lastname: Nam
authors.forename: Hwa-Young
authors.initials: HY
authors.lastname: Park
authors.forename: Mee-Yong
authors.initials: MY
authors.lastname: Shin
authors.forename: Sang-Il
authors.initials: SI
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000485:Allergens; D001249:Asthma / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000276:immunology; D004760:Enterocolitis / Q000276:immunology; D005260:Female; D005512:Food Hypersensitivity / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity; D007073:Immunoglobulin E / Q000097:blood / Q000378:metabolism; D007223:Infant; D007723:Korea; D008297:Male; D016269:Milk Hypersensitivity / Q000453:epidemiology* / Q000276:immunology; D015995:Prevalence; D012220:Rhinitis / Q000276:immunology; D030262:Soybean Proteins / Q000737:chemistry*; D014581:Urticaria / Q000276:immunology
chemical_list: D000485:Allergens; D030262:Soybean Proteins; D007073:Immunoglobulin E