title: Prospective study of peritoneal recurrence after curative surgery for gastric cancer.
abstract: BACKGROUND
  Peritoneal carcinomatosis is a common cause of failure after surgery for gastric cancer. The present longitudinal study was designed to evaluate the incidence and potential predictors of peritoneal recurrence after curative resection for gastric cancer.
  
  
  METHODS
  Four hundred and forty-one patients who underwent potentially curative resections for gastric cancer in three surgical centres between 1988 and 1996 were evaluated. All patients were followed using a standard protocol following discharge from hospital. The correlation between tumour recurrence and clinicopathological variables was studied by univariate and multivariate analyses.
  
  
  RESULTS
  Gastric cancer recurred in 215 (49 per cent) of 441 patients. Peritoneal recurrence was observed in 77 patients (17 per cent), locoregional recurrence in 96 patients and haematogenous recurrence in 75. Multivariate logistic regression analysis of factors associated with peritoneal recurrence identified diffuse-mixed histological type (relative risk (RR) 4.31, P < 0.001), infiltration of the serosa (RR 3.36, P = 0.001), lymph node involvement (RR 2.67, P = 0.023) and tumour size (RR 1.11, P = 0.050) as significant independent variables. In the diffuse-mixed histological subtype, the 5-year cumulative risk of peritoneal recurrence was 12 per cent in the absence of serosal invasion, and 69 per cent in patients with infiltration of the serosa; in the intestinal subtype, the cumulative risk in patients with serosa-negative and -positive tumours was 4 and 21 per cent respectively.
  
  
  CONCLUSIONS
  Radical surgery offers a low probability of cure in patients with diffuse-mixed type of gastric cancer and involvement of the serosa, due to a high risk of peritoneal recurrence. These patients might benefit from adjuvant therapies to prevent peritoneal carcinomatosis.
authors.affiliation: Unit of Surgical Oncology, University of Siena, Via da Gasperi 5, 53100 Siena, Italy. Riviello@unisi.it
authors.forename: F
authors.initials: F
authors.lastname: Roviello
authors.forename: D
authors.initials: D
authors.lastname: Marrelli
authors.forename: G
authors.initials: G
authors.lastname: de Manzoni
authors.forename: P
authors.initials: P
authors.lastname: Morgagni
authors.forename: A
authors.initials: A
authors.lastname: Di Leo
authors.forename: L
authors.initials: L
authors.lastname: Saragoni
authors.forename: A
authors.initials: A
authors.lastname: De Stefano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004812:Epidemiologic Methods; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000556:secondary*; D013274:Stomach Neoplasms / Q000601:surgery*