title: [Successful treatment with cyclosporine in a case of progressive interstitial pneumonia associated with systemic sclerosis].
abstract: A 55-year-old man was admitted to our hospital with dyspnea on effort and sclerodactyly. The chest radiograph showed reticulonodular shadows in both lower lung fields. A diagnosis of systemic sclerosis was made based on the characteristic skin lesions, interstitial pneumonia and the positivity for anti-Scl-70 antibody. Surgical biopsies were performed, which showed various features characteristic of organizing pneumonia and non-specific interstitial pneumonia. Prednisolone and cyclophosphamide were given to the patient, but clinical symptoms and chest radiographic findings worsened. After cyclophosphamide was replaced with cyclosporine, his symptoms, chest radiographic findings and pulmonary function improved and stabilized. It is suggested that cyclosporine is useful for the treatment of progressive interstitial pneumonia associated with systemic sclerosis.
authors.affiliation: Department of Respiratory Medicine, Shimada Municipal Hospital, Second Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yagi
authors.forename: Jun
authors.initials: J
authors.lastname: Kobayashi
authors.forename: Hideki
authors.initials: H
authors.lastname: Suganuma
authors.forename: Takahisa
authors.initials: T
authors.lastname: Saito
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Takashima
authors.forename: Yutarou
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Takafumi
authors.initials: T
authors.lastname: Suda
authors.forename: Kingo
authors.initials: K
authors.lastname: Chida
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D018549:Cryptogenic Organizing Pneumonia / Q000150:complications / Q000188:drug therapy*; D016572:Cyclosporine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D012595:Scleroderma, Systemic / Q000150:complications*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone