title: Effect of antibodies to histamine in ultralow doses on production of allergen-specific antibodies.
abstract: We studied the effects of potentiated antibodies to histamine on production of IgE and IgG1 in response to 3-fold immunization of mice with ovalbumin in doses of 0.5, 10, and 100 microg. The course of treatment with antibodies to histamine suppressed production of allergen-specific IgE and IgG1 in mice 2-fold immunized with ovalbumin in doses of 100 and 0.5 microg, respectively. In mice immunized 3 times with ovalbumin in various doses the preparation suppressed production of IgE and IgG1.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
authors.forename: V I
authors.initials: VI
authors.lastname: Agafonov
authors.forename: N V
authors.initials: NV
authors.lastname: Bel'skaya
authors.forename: M G
authors.initials: MG
authors.lastname: Danilets
authors.forename: Yu B
authors.initials: YB
authors.lastname: Bel'skii
authors.forename: E S
authors.initials: ES
authors.lastname: Trofimova
authors.forename: Yu L
authors.initials: YL
authors.lastname: Dugina
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000276:immunology*; D007110:Immunity, Active / Q000187:drug effects*; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007136:Immunoglobulins / Q000097:blood* / Q000276:immunology; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D051381:Rats
chemical_list: D000485:Allergens; D000906:Antibodies; D007074:Immunoglobulin G; D007136:Immunoglobulins; D007073:Immunoglobulin E; D006632:Histamine; D010047:Ovalbumin