Novel Pseudomonas aeruginosa gene that suppresses tolerance to carbapenems.
A biapenem-tolerant mutant of Pseudomonas aeruginosa was isolated by Tn1737KH insertion. The survival of the mutant 3 h after the addition of biapenem was about 1000 times greater than that of the wild type. The mutant was also tolerant to other biapenems, such as imipenem, panipenem, and meropenem.
Taniguchi
Kazuko
K
Department of Microbiology, Tokushima University School of Dentistry, Tokushima 770-8504, Japan.
Ono
Tsuneko
T
Murakami
Keiji
K
Viducic
Darija
D
Kayama
Sizuo
S
Hirota
Katsuhiko
K
Nemoto
Ken
K
Miyake
Yoichiro
Y
D000818:Animals; D015780:Carbapenems / Q000494:pharmacology*; D015169:Colony Count, Microbial; D017931:DNA Primers; D004251:DNA Transposable Elements / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics; D011550:Pseudomonas aeruginosa / Q000235:genetics*
D015780:Carbapenems; D017931:DNA Primers; D004251:DNA Transposable Elements