Galanin-immunoreactive nerve fibers in the periodontal ligament during experimental tooth movement.
Neuropeptides have been suggested to play a role in pain transmission during orthodontic tooth movement. We examined this hypothesis by examining the effect of orthodontic tooth movement on the expression of galanin (GAL)-immunoreactive (ir) nerve fibers in the periodontal ligament (PDL) of one mesial root (MR) and two distal roots (DRs) of the rat maxillary first molar. In control rats, GAL-ir fibers were very rare in the PDL. One day after the insertion of the elastic band, the number of GAL-ir fibers increased, becoming most numerous at 3 days. From 5 to 28 days, GAL-ir fibers tended to decrease. Electron microscopic observation showed that all of the GAL-ir fibers were unmyelinated. These findings suggest that GAL-containing nerve fibers in the PDL may play an important role in the response of the tissue to experimental tooth movement.
Deguchi
T
T
Department of Orthodontics, Okayama University Graduate School of Medicine and Dentistry, 2-5-1, Shikata-cho, Okayama, 700, Japan.
Takeshita
N
N
Balam
T A
TA
Fujiyoshi
Y
Y
Takano-Yamamoto
T
T
D000704:Analysis of Variance; D000818:Animals; D019004:Galanin / Q000032:analysis*; D007150:Immunohistochemistry; D008297:Male; D016253:Microscopy, Immunoelectron; D008963:Molar / Q000294:innervation; D009412:Nerve Fibers / Q000648:ultrastructure*; D036421:Nerve Fibers, Unmyelinated / Q000648:ultrastructure; D009967:Orthodontic Appliances; D010146:Pain / Q000503:physiopathology; D010513:Periodontal Ligament / Q000294:innervation*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014087:Tooth Movement Techniques / Q000295:instrumentation
D019004:Galanin