Diagnosis and treatment of actinic prurigo.
Actinic prurigo (AP) is an idiopathic photodermatosis that affects mainly the mestizo population in Latin America. It has an early onset, a slight predominance in women, and affects the sun-exposed areas of the skin, causing erythematous papules and lichenified plaques secondary to intense and chronic pruritus. Lesions can be induced by both ultraviolet A (UVA) and ultraviolet B (UVB). An association with several human leukocyte antigen (HLA) alleles has been reported. AP is unique among all photodermatoses in its remarkable response to thalidomide. In the past the microscopic features of AP have been considered as nonspecific; however, the constant finding of dense lymphocytic inflammatory infiltrates and the immunogenetic features of AP support the existence of an immunologic mechanism in its pathogenesis.
Hojyo-Tomoka
María-Teresa
MT
Department of Dermatology, Hospital General "Dr. Manuel Gea González," Mexico City, Mexico. dermagea@prodigy.net.mx
Vega-Memije
María-Elisa
ME
Cortes-Franco
Roberto
R
Domínguez-Soto
Luciano
L
D003879:Dermatologic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006801:Humans; D010787:Photosensitivity Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D011536:Prurigo / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D013792:Thalidomide / Q000627:therapeutic use
D003879:Dermatologic Agents; D013792:Thalidomide