An improved procedure for the synthesis of benzimidazoles, using palladium-catalyzed aryl-amination chemistry.
New, improved conditions have been developed and optimized for the synthesis of benzimidazoles by intramolecular palladium-catalyzed aryl-amination chemistry. This methodology, combined with a "catch and release" purification strategy, has led to a range of these heterocycles being prepared rapidly and in excellent yield.
Brain
Christopher T
CT
Novartis Institute for Medical Sciences, 5 Gower Place, London, WC1E 6BS, United Kingdom. christopher.brain@pharma.novartis.com
Steer
James T
JT
D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010165:Palladium
D001562:Benzimidazoles; D007202:Indicators and Reagents; D010165:Palladium