Ultrastructure of the pineal gland after gamma-irradiation under conditions of inhibition of adrenocortical function.
Electron microscopy showed that whole-body gamma-irradiation in sublethal doses led to the appearance of injuries in pinealocytes, glial cells, and vessels of the pineal gland in rats. Limitation of the nonspecific effect of gamma-irradiation via inhibition of adrenocortical function with metopirone in physiological doses reduced the radiation-induced ultrastructural damage to the pineal gland.
Popuchiev
V V
VV
Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. popoutch@mrrc.obninsk.ru
Yakovleva
N D
ND
Konoplyannikov
A G
AG
Kvetnoi
I M
IM
Kita
K
K
Kita
I
I
D000302:Adrenal Cortex / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005720:Gamma Rays; D008297:Male; D008797:Metyrapone / Q000494:pharmacology*; D010870:Pineal Gland / Q000528:radiation effects* / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar
D000963:Antimetabolites; D004791:Enzyme Inhibitors; D008797:Metyrapone