title: Transient splenial lesion of the corpus callosum associated with antiepileptic drugs: evaluation by diffusion-weighted MR imaging.
abstract: Transient focal lesions in the splenium of the corpus callosum have been reported in epileptic patients receiving antiepileptic drugs. The characteristic imaging features included an oval high signal lesion on T2-weighted images in the central part of the splenium, no enhancement on post-contrast MR images, and complete reversibility without specific treatment. We report identical MR imaging findings in a depressive patient who had received antiepileptic drugs. In addition, diffusion-weighted MR imaging findings are described in our case, which is the first report on this unique lesion associated with antiepileptic drugs. Although this lesion has been assumed to be vasogenic edema in the previous reports, diffusion-weighted MR imaging showed markedly restricted diffusion of the lesion in the present case, suggesting that cytotoxic edema was the main pathophysiological abnormality.
authors.affiliation: Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. mmaeda@clin.medic.mie-u.ac.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Maeda
authors.forename: Takashi
authors.initials: T
authors.lastname: Shiroyama
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tsukahara
authors.forename: Taro
authors.initials: T
authors.lastname: Shimono
authors.forename: Shigeki
authors.initials: S
authors.lastname: Aoki
authors.forename: Kan
authors.initials: K
authors.lastname: Takeda
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D003337:Corpus Callosum / Q000187:drug effects / Q000473:pathology*; D003863:Depression / Q000188:drug therapy; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans
chemical_list: D014151:Anti-Anxiety Agents; D000927:Anticonvulsants