title: The use of score tests for inference on variance components.
abstract: Whenever inference for variance components is required, the choice between one-sided and two-sided tests is crucial. This choice is usually driven by whether or not negative variance components are permitted. For two-sided tests, classical inferential procedures can be followed, based on likelihood ratios, score statistics, or Wald statistics. For one-sided tests, however, one-sided test statistics need to be developed, and their null distribution derived. While this has received considerable attention in the context of the likelihood ratio test, there appears to be much confusion about the related problem for the score test. The aim of this paper is to illustrate that classical (two-sided) score test statistics, frequently advocated in practice, cannot be used in this context, but that well-chosen one-sided counterparts could be used instead. The relation with likelihood ratio tests will be established, and all results are illustrated in an analysis of continuous longitudinal data using linear mixed models.
authors.affiliation: Biostatistical Centre, Catholic University of Leuven, U.Z. St.-Rafaël, Kapucijnenvoer 35, B-3000 Leuven, Belgium. geert.verbeke@med.kuleuven.ac.be
authors.forename: Geert
authors.initials: G
authors.lastname: Verbeke
authors.forename: Geert
authors.initials: G
authors.lastname: Molenberghs
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003627:Data Interpretation, Statistical; D006727:Hormone Antagonists / Q000494:pharmacology; D016013:Likelihood Functions; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012886:Skull / Q000254:growth & development; D013739:Testosterone / Q000037:antagonists & inhibitors; D017329:Triptorelin Pamoate / Q000494:pharmacology
chemical_list: D006727:Hormone Antagonists; D017329:Triptorelin Pamoate; D013739:Testosterone