title: [Role of neuraminidase in pathogenesis of influenza].
abstract: The influenza neuraminidase (NA) possesses, both in vivo and in vitro, the anticoagulant and fibrinolytic activity. A computerized comparative analysis of the influenza NA viruses, type A, showed nine regions of amino-acid sequences compatible with the tissue activator of human plasminogen. The mentioned regions are highly conservative for each NA subtype irrespective of a source or a year, when an influenza strain was isolated. The role of NA in pathogenesis of influenza infection is under consideration.
authors.forename: I N
authors.initials: IN
authors.lastname: Zhilinskaia
authors.forename: L A
authors.initials: LA
authors.lastname: Liapina
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Reshetnikova
authors.forename: O I
authors.initials: OI
authors.lastname: Kisleev
mesh_terms: D000595:Amino Acid Sequence; D005342:Fibrinolysis; D006801:Humans; D009980:Influenza A virus / Q000201:enzymology / Q000472:pathogenicity*; D007251:Influenza, Human / Q000201:enzymology*; D008969:Molecular Sequence Data; D009439:Neuraminidase / Q000378:metabolism*
chemical_list: D009439:Neuraminidase