title: Metal-ion-assisted hydrolysis of dipeptides involving a serine residue in a neutral aqueous solution.
abstract: Dipeptides having a serine residue at the C-terminus, X-Ser, where X is an appropriate amino acid residue, were efficiently hydrolyzed in the presence of ZnCl2 at pH 7.0. The rapid hydrolysis of X-Ser is due to an autocatalysis of the hydroxy group in the serine residue, and is found to be accelerated by a metal ion, in particular by ZnCl2. Roles of the metal ion in the hydrolysis of peptides involving a serine residue, in relation to the recently reported protein cleavages, are discussed.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Tokyo Institute of Polytechnics, 1583 Iiyama, Atsugi, Kanagawa 243-0297, Japan. yashiro@chem.t-kougei.ac.jp
authors.forename: Morio
authors.initials: M
authors.lastname: Yashiro
authors.forename: Yoko
authors.initials: Y
authors.lastname: Sonobe
authors.forename: Ai
authors.initials: A
authors.lastname: Yamamura
authors.forename: Tohru
authors.initials: T
authors.lastname: Takarada
authors.forename: Makoto
authors.initials: M
authors.lastname: Komiyama
authors.forename: Yuki
authors.initials: Y
authors.lastname: Fujii
mesh_terms: D002712:Chlorides / Q000737:chemistry; D004151:Dipeptides / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D008670:Metals / Q000737:chemistry*; D012694:Serine / Q000737:chemistry*; D012996:Solutions; D017967:Zinc Compounds / Q000737:chemistry
chemical_list: D002712:Chlorides; D004151:Dipeptides; D008670:Metals; D012996:Solutions; D017967:Zinc Compounds; D012694:Serine; C016837:zinc chloride