Potentiated antibodies to mu-opiate receptors: effect on integrative activity of the brain.
The effect of homeopathically potentiated antibodies to mu-receptors (10(-100) wt %) on integrative activity of rat brain was studied using the models of self-stimulation of the lateral hypothalamus and convulsions produced by electric current. Electric current was delivered through electrodes implanted into the ventromedial hypothalamus. Single treatment with potentiated antibodies to mu-receptors increased the rate of self-stimulation and decreased the threshold of convulsive seizures. Administration of these antibodies for 7 days led to further activation of the positive reinforcement system and decrease in seizure thresholds. Distilled water did not change the rate of self-stimulation and seizure threshold.
Geiko
V V
VV
Institute of Neurology, Psychiatrics, and Narcology, Ukrainian Academy of Medical Sciences, Kharkov.
Vorob'eva
T M
TM
Berchenko
O G
OG
Epstein
O I
OI
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D009292:Narcotic Antagonists; D051381:Rats; D011957:Receptors, Opioid / Q000276:immunology; D012640:Seizures / Q000188:drug therapy; D012653:Self Stimulation / Q000187:drug effects*
D000906:Antibodies; D009292:Narcotic Antagonists; D011957:Receptors, Opioid