From central to planar chirality, the first example of atropenantioselective cycloetherification.
Using chiral quaternary ammonium hydroxide as base, cycloetherification of linear achiral diarylheptanoid 5, by way of an intramolecular SNAr reaction, provides enantiomerically enriched cyclophane 6 in good to excellent yield.
Islas-Gonzalez
Gabriela
G
Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette, France.
Bois-Choussy
Michèle
M
Zhu
Jieping
J