title: Off-label applications for SSRIs.
abstract: Selective serotonin reuptake inhibitors (SSRIs) are widely used because of their safety, tolerability, and demonstrated efficacy across a broad range of clinical conditions. Medical literature supports the use of SSRIs for the treatment of many conditions outside of the indications approved by the U.S. Food and Drug Administration. SSRIs offer a reasonable alternative to traditional therapy for generalized anxiety disorder. A side effect of SSRIs coincidentally provides therapy for premature ejaculation. SSRIs may reduce the frequency and severity of migraine headaches and are possibly effective in reducing the pain of diabetic neuropathy. When taken in combination with tricyclic antidepressants, SSRis offer more potent therapy for fibromyalgia than either agent alone. SSRIs appear to be effective in some patients with neurocardiogenic syncope that is refractory to standard therapies. Clinical experience supported by ongoing research continues to expand on the broad array of therapeutic applications for this class of medication.
authors.affiliation: Naval Hospital Jacksonville, Florida 32214, USA.
authors.forename: Kimberly J
authors.initials: KJ
authors.lastname: Stone
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Viera
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Parman
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy; D002986:Clinical Trials as Topic; D017277:Drug Approval; D004363:Drug Utilization; D005356:Fibromyalgia / Q000188:drug therapy; D006801:Humans; D012449:Safety; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D017367:Selective Serotonin Reuptake Inhibitors