[Effect of thymostimulin and thyroxine on lipid peroxidation and antioxidant enzyme activity in experimental hypothyrosis].
In the livers and spleens of pseudoectomized, thymectomized, thymthyroidectomized mice and thyroidectomized rats there is clear regularity in the change of lipid peroxidation intensity antioxidant system and enzymes activity depending on the severity and duration of pathologic changes occurred in organism and biological significance of the removed endocrine glands in maintenance of homeostasis. Thymostimulin and thyroxin do not render a direct effect on the intensity of lipid peroxidation, but their injection to the thyroidectomized rats indirectly normalizes content of peroxidant products in tissues of liver and spleen and restores disordered metabolism processes as a result of thyroid gland ectomia.
Bilokin'
Iu M
IuM
Institute of Oncology, AMS of Ukraine, Kyiv.
Bendiuh
H D
HD
Raiets'ka
Ia B
IaB
Hrinevych
Iu Ia
IuIa
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D006023:Glycoproteins / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D010084:Oxidation-Reduction; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013934:Thymectomy; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology*
D000975:Antioxidants; D006023:Glycoproteins; C458339:thyrostimulin; D002374:Catalase; D013482:Superoxide Dismutase; D013974:Thyroxine