title: [Detection of sexual hormone in semen of patients with idiopathic azoospermia or oligospermia and its significance].
abstract: OBJECTIVE
  To detect the sexual hormone level in semen of patients with idiopathic azoospermia and oligospermia, and further analyze the relationship between sexual hormone and idiopathic azoospermia and oligospermia.
  
  
  METHODS
  50 male patients with idiopathic azoospermia, 50 in idiopathic oligospermia and 50 male controls with normal sperm density were selected. The sperm density and sexual hormone in semen were detected respectively by routine semen analysis and chemical luminescence technique.
  
  
  RESULTS
  The values of LH were (5.19 +/- 0.67) IU/L and (4.77 +/- 0.68) IU/L, and those of FSH were (1.90 +/- 0.79) IU/L and (2.27 +/- 0.25) IU/L in idiopathic azoospermia and oligospermia respectively, and the values of LH and FSH were (2.19 +/- 0.22) IU/L and (1.61 +/- 0.14) IU/L in normal control group respectively. There were significant differences in the values of LH and FSH between idiopathic azoospermia and normal control group(P < 0.01 or P < 0.05). The values of PRL were (6.25 +/- 0.51) ng/ml and (6.33 +/- 0.34) ng/ml, and those of T were (1.51 +/- 0.12) ng/ml and (1.68 +/- 0.71) ng/ml in idiopathic azoospermia and oligospermia respectively, and the values of PRL and T were (6.36 +/- 0.32) ng/ml and (1.83 +/- 0.09) ng/ml in normal control group respectively. There were no significant difference in the values of PRL between idiopathic azoospermia, oligospermia and normal control group, but there were significant differences of T between idiopathic azoospermia and normal control. Compared with 0.84 +/- 0.20 in normal control, the values of T/LH were 0.35 +/- 0.09 and 0.29 +/- 0.04 in idiopathic oligospermia and azoospermia respectively and there were significant differences(P < 0.05).
  
  
  CONCLUSIONS
  The changes of LH, FSH and T values may be one of the reasons that cause the dysfunction of spermatogenesis and sperm maturation in patients with idiopathic azoospermia and oligospermia. The study of semen hormone may lead to new strategies in the treatment to azoospermia and oligospermia.
authors.affiliation: Laboratory of Reproduction & Genetics, Nanjing General Hospital, Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
authors.forename: Jin-Rong
authors.initials: JR
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Yao
authors.forename: Yong-Mei
authors.initials: YM
authors.lastname: Wang
authors.forename: Ying-Xia
authors.initials: YX
authors.lastname: Cui
authors.forename: Shu-Kui
authors.initials: SK
authors.lastname: Wang
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Ge
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Huang
mesh_terms: D000328:Adult; D053713:Azoospermia / Q000378:metabolism*; D016022:Case-Control Studies; D005640:Follicle Stimulating Hormone / Q000032:analysis*; D006801:Humans; D007986:Luteinizing Hormone / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009845:Oligospermia / Q000378:metabolism*; D012661:Semen / Q000737:chemistry*; D013076:Sperm Count; D013739:Testosterone / Q000032:analysis*
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone