title: Taking the A-train: actin-based force generators and organelle targeting.
abstract: The actin-driven process of cytoplasmic streaming in plant cells is widely believed to be the earliest documented example of cytoskeleton-driven organelle movement. In the decades since these seminal findings, two mechanisms of actin-based intracellular movement have been identified in multiple cell types: one is myosin dependent and the other is dependent upon the Arp2/3 complex for actin nucleation and polymerization. Here, we describe mechanisms of force generation and directed movement that use the actin cytoskeleton, as well as those that target actin-dependent force generators to different subcellular compartments.
authors.affiliation: Department of Anatomy and Cell Biology, Columbia University, 630 West 168th Street-P&S 12-425, New York, NY 10032, USA.
authors.forename: Kammy L
authors.initials: KL
authors.lastname: Fehrenbacher
authors.forename: Istvan R
authors.initials: IR
authors.lastname: Boldogh
authors.forename: Liza A
authors.initials: LA
authors.lastname: Pon
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D008958:Models, Molecular; D020409:Molecular Motor Proteins / Q000378:metabolism*; D024701:Myosin Type V / Q000378:metabolism; D015388:Organelles / Q000502:physiology*
chemical_list: D000199:Actins; D020409:Molecular Motor Proteins; D024701:Myosin Type V