Measurement of cefaclor and amoxicillin-clavulanic acid levels in middle-ear fluid in patients with acute otitis media.
Concentrations of cefaclor (CFC) or amoxicillin-clavulanic acid (AMX/CA) in middle-ear fluid collected preserving the stability and clearing the cell contents has been compared to those obtained using the traditional method. Sixty-seven children with effusive otitis media were treated orally with CFC (20 mg/kg of body weight) or AMX/CA (20 mg/kg) (4:1 ratio). The concentrations in cell-free fluid (C-) appear higher than those in the total fluid (C+) (as assayed traditionally).
Scaglione
F
F
University of Milan, Milan, Italy. francesco.scaglione@unimi.it
Caronzolo
D
D
Pintucci
J P
JP
Fraschini
F
F
D000208:Acute Disease; D000293:Adolescent; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000032:analysis* / Q000493:pharmacokinetics; D019540:Area Under Curve; D001826:Body Fluids / Q000737:chemistry / Q000166:cytology; D002433:Cefaclor / Q000032:analysis* / Q000493:pharmacokinetics; D002511:Cephalosporins / Q000032:analysis* / Q000493:pharmacokinetics; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D004359:Drug Therapy, Combination / Q000032:analysis* / Q000493:pharmacokinetics; D004432:Ear, Middle / Q000737:chemistry* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male
D002511:Cephalosporins; D002433:Cefaclor; D019980:Amoxicillin-Potassium Clavulanate Combination