title: [Central hemodynamics during therapeutic sedation in children under artificial pulmonary ventilation].
abstract: A total of 46 patients, aged 9 to 14, who underwent the artificial ventilation of the lungs (AVL) for diffusive purulent peritonitis with laparostoma, spastic syndrome, destructive pneumonia, and crania-cerebral trauma of different severities, were investigated. The patients were divided into 3 groups with respect to a medicamental sedation. Group 1--bolus dosing of a 20% solution of gamma oxy-oil acid (GOOA), 75-100 mg/kg; group 2--bolus dosing of a 1% solution of thiopental sodium (5-7 mg/kg); and group 3--micro-flow introduction of dormycum (0.1 mg/kg x h). The central hemodynamics was studied by the NCCKOM apparatus ("Bomed", USA) by applying a non-invasive technique. Stroke volume, cardiac rate, circulation minute volume, mean arterial pressure and general peripheral vascular resistance were determined. The sedation level was assessed by Cook's and Palma's scale (1989). The above investigations showed that all used techniques insured a satisfactory functioning of the cardiovascular system, but the highest stability of parameters was registered in the group, in which COOA was applied. The highest level of sedation and comfort was registered in the group of patients, which received dormycum. A conclusion was made on the basis of the conducted study that the technique of the micro-flow introduction of dormycum indicated for AVL in children is an adequate and stable sedation technique producing a minimal impact on the hemodynamics.
authors.forename: Zh I
authors.initials: ZhI
authors.lastname: Petrova
authors.forename: M K
authors.initials: MK
authors.lastname: Shtatnov
authors.forename: V V
authors.initials: VV
authors.lastname: Nikitin
authors.forename: S V
authors.initials: SV
authors.lastname: Tarasov
authors.forename: I F
authors.initials: IF
authors.lastname: Ostreĭkov
mesh_terms: D000293:Adolescent; D001007:Anxiety / Q000503:physiopathology / Q000517:prevention & control; D002648:Child; D016292:Procedural Sedation / Q000379:methods*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use*; D008874:Midazolam / Q000008:administration & dosage / Q000627:therapeutic use; D012121:Respiration, Artificial / Q000523:psychology*; D012978:Sodium Oxybate / Q000008:administration & dosage / Q000627:therapeutic use; D013874:Thiopental / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D006993:Hypnotics and Sedatives; D012978:Sodium Oxybate; D013874:Thiopental; D008874:Midazolam