Studies of adipose tissue metabolism in human immunodeficiency virus-associated lipodystrophy.
We studied aspects of metabolism in subcutaneous adipose tissue (SAT) in 40 human immunodeficiency virus (HIV)-infected subjects with and without lipodystrophy and in healthy control subjects. HIV-infected subjects without lipodystrophy had less SAT and visceral adipose tissue (VAT). Glycerol release was higher in both HIV-infected groups, especially those without fat redistribution. Tumor necrosis factor (TNF) release from SAT and serum soluble TNF receptor 2 concentrations were significantly higher in HIV-infected individuals with lipodystrophy. The absolute production of acylation-stimulating protein (ASP) and the percentage conversion of the complement protein to ASP were significantly lower in HIV-infected subjects with lipodystrophy. Further studies are needed to dissect the factors that mediate lipoatrophy in HIV infection.
Kotler
Donald P
DP
Division of Gastroenterology, Obesity Research Center, Department of Medicine, St. Luke's-Roosevelt Hospital Center, College of Physicians and Surgeons, Columbia University, New York, New York 10025, USA. DPKotler@aol.com
Ionescu
Gabriel
G
Johnson
Julia A
JA
Inada
Yori
Y
He
Qing
Q
Engelson
Ellen S
ES
Albu
Jeanine B
JB
D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology; D001798:Blood Proteins / Q000378:metabolism*; D001823:Body Composition; D015926:Complement C3a / Q000031:analogs & derivatives*; D003430:Cross-Sectional Studies; D046508:Culture Techniques; D005260:Female; D005990:Glycerol / Q000378:metabolism*; D015658:HIV Infections / Q000188:drug therapy / Q000378:metabolism*; D039682:HIV-Associated Lipodystrophy Syndrome / Q000378:metabolism*; D006801:Humans; D008066:Lipolysis / Q000502:physiology; D008297:Male; D011446:Prospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D019380:Anti-HIV Agents; D001798:Blood Proteins; D014409:Tumor Necrosis Factor-alpha; C044541:complement C3a, des-Arg-(77)-; D015926:Complement C3a; D005990:Glycerol