[Prevention of adverse reactions of antituberculous drugs in pulmonary tuberculosis in patients with different genetic background].
To study genetic predisposition to adverse reactions caused by drugs, 367 patients with pulmonary tuberculosis were examined. As a genetic marker, the phenotype of haptoglobin (Hp) carriage, the type of HINC inactivation, the activity of the enzyme G-6-PDHG were determined. Adverse reactions were noted in 60.2% of the patients. If there was an unfavourable combination of genetic markers, adverse reactions developed in 100% of the patients, with a relatively unfavourable combination, adverse reactions did in a slightly smaller proportion (78%). With a relatively favourable combination, they were noted only in 38%. A new technology is proposed for the prevention of adverse reactions in pulmonary tuberculosis by using nontraditional treatments, phytotherapy and its combination with ultrasound autoblood radiation. The use of this technology has been shown to reduce the incidence of adverse reactions, to diminish the severity and clinical manifestations of disease.
Tashpulatova
F K
FK
D000995:Antitubercular Agents / Q000009:adverse effects*; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008517:Phytotherapy / Q000379:methods*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000235:genetics* / Q000628:therapy*
D000995:Antitubercular Agents; D005819:Genetic Markers