title: [Genetic variability of Bordetella pertussis strains. Part I. Current knowledge].
abstract: Variability of B. pertussis genome concerning S1 subunit of pertussis toxin (ptxS1) and pertactin (prn) genes has recently been recognised. Studies clearly showed differences in the DNA patterns and ptxS1 and prn alleles present in B. pertussis strains used for production of pertussis component in the DTP vaccine, in comparison to strains presently isolated from clinical materials. This trend has been observed in highly immunized populations with a long history of pertussis vaccination (The Netherlands, Finland, Poland, USA). Different ptxS1 and prn allele distribution for different countries needs further careful monitoring.
authors.affiliation: Zakład Badania Surowic i Szczepionek Państwowego Zakładu Higieny ul. Chocimska 24, 00-791 Warszawa. agzyl@pzh.gov.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Gzyl
authors.forename: Ewa
authors.initials: E
authors.lastname: Augustynowicz
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Gniadek
authors.forename: Janusz
authors.initials: J
authors.lastname: Slusarczyk
mesh_terms: D000483:Alleles; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D001886:Bordetella pertussis / Q000235:genetics*; D004269:DNA, Bacterial; D005060:Europe; D014644:Genetic Variation; D006801:Humans; D037342:Pertussis Toxin; D010567:Pertussis Vaccine / Q000235:genetics*; D011993:Recombinant Fusion Proteins / Q000235:genetics; D014481:United States
chemical_list: D001425:Bacterial Outer Membrane Proteins; D004269:DNA, Bacterial; D010567:Pertussis Vaccine; D011993:Recombinant Fusion Proteins; D037342:Pertussis Toxin