title: Forward mandibular positioning up-regulates SOX9 and type II collagen expression in the glenoid fossa.
abstract: Regulatory factors governing the formation of bone in the glenoid fossa in response to functional appliance therapy have not been identified. Therefore, the purpose of this study was to investigate the temporal pattern of expression of two key chondrogenesis markers-SOX9 and its target gene, type II collagen-in the glenoid fossa by immunostaining in a 35-day-old Sprague Dawley rat model during both natural growth and forward mandibular positioning. The expression of both factors was up-regulated when the mandible was positioned forward, indicating an enhancement of chondrocyte differentiation and chondroid matrix formation. Our results indicate that chondroid bone formation in the glenoid fossa in response to forward mandibular positioning is regulated by molecular markers indicative of endochondral ossification.
authors.affiliation: Hard tissue biology and repair research group and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong SAR, China.
authors.forename: A B M
authors.initials: AB
authors.lastname: Rabie
authors.forename: T T
authors.initials: TT
authors.lastname: She
authors.forename: V R
authors.initials: VR
authors.lastname: Harley
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D019902:Chondrocytes / Q000187:drug effects; D020219:Chondrogenesis / Q000187:drug effects; D024043:Collagen Type II / Q000032:analysis* / Q000235:genetics; D005109:Extracellular Matrix / Q000187:drug effects; D005260:Female; D006609:High Mobility Group Proteins / Q000032:analysis* / Q000235:genetics; D008334:Mandible / Q000033:anatomy & histology* / Q000254:growth & development; D023421:Models, Animal; D017289:Orthodontic Appliances, Functional; D010012:Osteogenesis / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D055758:SOX9 Transcription Factor; D013701:Temporal Bone / Q000254:growth & development / Q000378:metabolism*; D014157:Transcription Factors / Q000032:analysis* / Q000235:genetics; D015854:Up-Regulation / Q000235:genetics
chemical_list: D024043:Collagen Type II; D006609:High Mobility Group Proteins; D055758:SOX9 Transcription Factor; D014157:Transcription Factors