[Participation of the GABA system in tha adaptive rearrangement of the cerebral circulation in hypokinesia].
Hypokinesia involves a number of significant biochemical, histochemical, and pathophysiological changes in brain tissues, vessels, and neurocytes, including glucose metabolism disturbances, calcium level violation and transduction in synaptosomes, changes, on the levels of neuroactive amino acids, nitric oxide, and lipid peroxidation products. All these variations depend on the terms of hypokinesia. It is established that GABA, together with other neuromediators, play an important role in the adaptation process. GABAergic drugs produce effects indicative of the activation of processes leading to compensation and, probably, elimination of the aforementioned negative changes.
Akopian
V P
VP
Department of Pharmacology, Yerevan State Medical University, ul. Koryuna 2, Yerevan, 375025 Armenia.
D000222:Adaptation, Physiological; D000818:Animals; D002560:Cerebrovascular Circulation; D006801:Humans; D018476:Hypokinesia / Q000378:metabolism* / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D005680:gamma-Aminobutyric Acid