Reactivity of tracheal smooth muscles in albino rats with experimental diabetes mellitus treated with a new complex compound of oxovanadium (IV) and isonicotinic acid hydrazide.
We studied functional properties of tracheal smooth muscle cells in rats with diabetes mellitus. Reactivity of tracheal smooth muscles increased in rats with experimental alloxan-induced diabetes mellitus. A new complex compound of oxovanadium (IV) and isonicotinic acid hydrazide affected reactivity of tracheal smooth muscles in albino rats with experimental type I diabetes mellitus. This new organic vanadium-containing compound reduced contractility of tracheal smooth muscles in rats and potentiated relaxation of smooth muscle cells in the trachea in response to exogenous nitric oxide.
Khafiz'yanova
R Kh
RKh
Department of Pharmacology, Department of Pathophysiology, Kazan' State Medical University.
Minnebaev
M M
MM
Gallyamov
R M
RM
Latypov
R S
RS
Gosmanov
A R
AR
Aleeva
G N
GN
D000496:Alloxan; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D018679:Cholinergic Agonists / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D004338:Drug Combinations; D005260:Female; D007538:Isoniazid / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects* / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D014132:Trachea / Q000033:anatomy & histology / Q000378:metabolism*; D014638:Vanadates / Q000494:pharmacology* / Q000627:therapeutic use
D018679:Cholinergic Agonists; D004338:Drug Combinations; C075743:oxovanadium IV; D009569:Nitric Oxide; D014638:Vanadates; D000496:Alloxan; D002217:Carbachol; D007538:Isoniazid