Nonenzymatic peptide-based catalytic asymmetric phosphorylation of inositol derivatives.
The ability to use small peptides as catalysts for asymmetric phosphorylation provides opportunities for rapid syntheses of phosphate-containing compounds and natural products. This short review outlines the genesis of this concept and its reduction to practice in the context of concise syntheses of the enantiomeric D-I-1P and D-I-3P targets. The implications for the development of additional site-selective catalysts are discussed.
Sculimbrene
Bianca R
BR
Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA.
Morgan
Adam J
AJ
Miller
Scott J
SJ
D002384:Catalysis; D007295:Inositol Phosphates / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D008956:Models, Chemical; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry*; D010766:Phosphorylation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D007295:Inositol Phosphates; D010455:Peptides; C002647:inositol 1-phosphate; C052128:inositol 3-phosphate