Allograft inflammatory factor-1 regulates trinitrobenzene sulphonic acid-induced colitis.
The expression of allograft inflammatory factor-1 (AIF-1) in 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis, a model for T helper 1 (Th1) type disease, was investigated in BALB/c mice. The AIF-1 expression was significantly increased in the colitis lesion compared to that in the normal colon. We then prepared AIF-1 transgenic mice (Tgm) with the BALB/c background that express high levels of AIF-1 in lymphoid tissues and the colon. When AIF-1 Tgm were administrated TNBS, the TNBS-induced colitis was ameliorated compared with that in non-transgenic littermates. The amelioration of colitis was associated with the low expression of interleukin-1beta in the colon. The present findings suggest that AIF-1 regulates Th1-type inflammatory responses.
Morohashi
Taiki
T
Division of Immunobiology, Research Section of Pathophysiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
Iwabuchi
Kazuya
K
Watano
Keiko
K
Dashtsoodol
Nyambayar
N
Mishima
Tetsuya
T
Nakai
Yukihito
Y
Shimada
Shigeki
S
Nishida
Ryutaro
R
Fujii
Satoshi
S
Onoé
Kazunori
K
D000818:Animals; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000502:physiology*; D003092:Colitis / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D003106:Colon / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D015870:Gene Expression; D007375:Interleukin-1 / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D008840:Microfilament Proteins; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018417:Th1 Cells / Q000276:immunology; D014302:Trinitrobenzenesulfonic Acid
C491049:Aif1 protein, mouse; D002135:Calcium-Binding Proteins; D016207:Cytokines; D007375:Interleukin-1; D008840:Microfilament Proteins; D012333:RNA, Messenger; D014302:Trinitrobenzenesulfonic Acid