title: Designing proteins for therapeutic applications.
abstract: Protein design is becoming an increasingly useful tool for optimizing protein drugs and creating novel biotherapeutics. Recent progress includes the engineering of monoclonal antibodies, cytokines, enzymes and viral fusion inhibitors.
authors.affiliation: Xencor, 111 West Lemon Avenue, Monrovia, CA 91016, USA.
authors.forename: Greg A
authors.initials: GA
authors.lastname: Lazar
authors.forename: Shannon A
authors.initials: SA
authors.lastname: Marshall
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Plecs
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Mayo
authors.forename: John R
authors.initials: JR
authors.lastname: Desjarlais
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D016207:Cytokines / Q000494:pharmacology; D006801:Humans; D015202:Protein Engineering; D011506:Proteins / Q000494:pharmacology*
chemical_list: D000911:Antibodies, Monoclonal; D000998:Antiviral Agents; D016207:Cytokines; D011506:Proteins