Non-covalent stabilization of a beta-hairpin peptide into liposomes.
An oligopeptide modified on both the N- and C-termini with hydrophobic moieties was prepared on a solid phase and anchored into a liposome, stabilizing the fold of the peptide into a beta-hairpin, which would otherwise be a random coil.
Löwik
Dennis W P M
DW
Department of Organic Chemistry University of Nijmegen, Toernooiveld 1-U177, 6525 ED Nijmegen, The Netherlands. lowik@sci.kun.nl
Linhardt
Jeffrey G
JG
Adams
P J Hans M
PJ
van Hest
Jan C M
JC
D000595:Amino Acid Sequence; D000818:Animals; D002942:Circular Dichroism; D008081:Liposomes / Q000737:chemistry*; D008958:Models, Molecular; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry; D010963:Plasmodium falciparum; D011312:Pressure; D017433:Protein Structure, Secondary; D015800:Protozoan Proteins / Q000235:genetics
D008081:Liposomes; D009842:Oligopeptides; D010713:Phosphatidylcholines; D015800:Protozoan Proteins