Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance.
In this paper we show that Clostridium perfringens epsilon-toxin accumulates predominantly in the mouse kidney, where it is distributed mainly in glomeruli, capillaries, and collecting ducts. Although some pycnotic and exfoliated epithelial cells were observed in distal tubuli and collecting ducts, there were no findings indicative of severe renal injury. Bilateral nephrectomy increased the mouse lethality of the toxin, suggesting that the kidney contributes to the host defense against the lethal toxicity of epsilon-toxin.
Tamai
Eiji
E
Department of Microbiology, Faculty of Medicine, Kagawa Medical University, 1750-1 Ikenobe, Kita-gun, Kagawa 761-0793, Japan.
Ishida
Tetsuya
T
Miyata
Shigeru
S
Matsushita
Osamu
O
Suda
Hirofumi
H
Kobayashi
Shoji
S
Sonobe
Hiroshi
H
Okabe
Akinobu
A
D000818:Animals; D001427:Bacterial Toxins / Q000493:pharmacokinetics* / Q000633:toxicity*; D003015:Clostridium Infections / Q000209:etiology / Q000382:microbiology / Q000473:pathology; D003016:Clostridium perfringens / Q000472:pathogenicity*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D009392:Nephrectomy; D011994:Recombinant Proteins / Q000493:pharmacokinetics / Q000633:toxicity; D014018:Tissue Distribution
D001427:Bacterial Toxins; C039811:Clostridium perfringens epsilon-toxin; D011994:Recombinant Proteins