Dishevelled: linking convergent extension with neural tube closure.
Neural tube closure fails in both mouse and Xenopus when dishevelled and other components of the planar-cell-polarity pathway are misregulated. The underlying defect involves a failure of convergent extension in the midline of the early neural plate. Although bilateral neural folds form, they are abnormally far apart and cannot achieve the apposition necessary for neural tube closure.
Copp
Andrew J
AJ
Neural Development Unit, Institute of Child Health, University College, London WC1N 1EH, UK. a.copp@ich.ucl.ac.uk
Greene
Nicholas D E
ND
Murdoch
Jennifer N
JN
D000818:Animals; D016764:Cell Polarity / Q000235:genetics; D002490:Central Nervous System / Q000002:abnormalities* / Q000196:embryology*; D009436:Neural Tube Defects / Q000235:genetics* / Q000473:pathology*