title: Synergistic effects of pyrantel and the febantel metabolite fenbendazole on adult Toxocara canis.
abstract: Pyrantel embonate and febantel are both constituents of Drontal Plus and Drontal Puppy broad spectrum anthelmintics for dogs. The effects of pyrantel and the febantel metabolite fenbendazole were investigated against Toxocara canis in-vitro by studying changes in worm motility and tissue damage. Pyrantel and fenbendazole were added to worms incubated in media for 8 h at the following concentrations: pyrantel: 12.2 microg, 25 microg, or 50 microg; fenbendazole: 50 microg, 100 microg or 200 microg; mixture of pyrantel and fenbendazole: 12.2 microg p + 50 microg f, 25 microg p + 100 microg f, 50 microg p + 200 microg f. Following this 8 h incubation period, one group of the worms was immediately fixed and studied by light- and electron microscopical examination. Other groups have been observed for further 8 h periods up to 56 hours and then studied in the same way.
authors.affiliation: Institute for Zoomorphology, Cell Biology and Parasitology, Heinrich-Heine University, D-40225 Düsseldorf, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Mehlhorn
authors.forename: E
authors.initials: E
authors.lastname: Hanser
authors.forename: A
authors.initials: A
authors.lastname: Harder
authors.forename: O
authors.initials: O
authors.lastname: Hansen
authors.forename: N
authors.initials: N
authors.lastname: Mencke
authors.forename: R
authors.initials: R
authors.lastname: Schaper
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D004357:Drug Synergism; D005273:Fenbendazole / Q000494:pharmacology*; D006146:Guanidines / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D011715:Pyrantel / Q000494:pharmacology*; D017166:Toxocara canis / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure
chemical_list: D000969:Antinematodal Agents; D006146:Guanidines; D011715:Pyrantel; D005273:Fenbendazole; C017309:febantel