Treatment of pulmonary hemorrhage in childhood systemic lupus erythematosus with mycophenolate mofetil.
Systemic lupus erythematosus is a chronic autoimmune disease of unknown etiology with multisystem involvement. Pulmonary hemorrhage is a major life-threatening manifestation in children and adolescents with systemic lupus erythematosus, as well as in adults. Treatment has traditionally been with high-dose corticosteroids, with or without the addition of cytotoxic agents. We report the response of a patient with childhood systemic lupus erythematosus with recurrent pulmonary hemorrhage to treatment with mycophenolate mofetil.
Samad
Ahmed S
AS
Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas 66160-7330, USA.
Lindsley
Carol B
CB
D000293:Adolescent; D003131:Combined Modality Therapy; D018450:Disease Progression; D004359:Drug Therapy, Combination; D006470:Hemorrhage / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008171:Lung Diseases / Q000175:diagnosis / Q000188:drug therapy*; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000188:drug therapy*; D008181:Lupus Nephritis / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use*; D010956:Plasmapheresis; D011241:Prednisone / Q000627:therapeutic use; D012121:Respiration, Artificial
D007166:Immunosuppressive Agents; D006886:Hydroxychloroquine; D009173:Mycophenolic Acid; D011241:Prednisone; D008775:Methylprednisolone