title: [Correlation between integrin alpha5beta1 expression in colorectal carcinomas and the biological behavior of the carcinoma cells].
abstract: OBJECTIVE
  To study the correlation between the expression of integrin alpha5beta1 in colorectal carcinomas and the differentiation and metastasis of the tumor cells.
  
  
  METHODS
  The expression levels of integrin alpha5beta1 were detected immunohistochemically in 81 pairs of cancerous and non-cancerous tissues of patients with colorectal cancer.
  
  
  RESULTS
  The expression of integrin alpha5beta1 was significantly higher in the samples of colorectal carcinomas, than in non-cancerous tissues (P<0.05). Lower expression levels were detected in moderately or well differentiated colorectal carcinomas than in poorly differentiated ones (P<0.05). No significant relation was noted between the expression of integrin alpha5beta1 and lymph node metastasis of the colorectal carcinomas (P>0.05).
  
  
  CONCLUSIONS
  Alpha5beta1 expression is significantly associated with the carcinogenesis and differentiation of colorectal carcinomas, but not with their lymph node metastasis, and the expression level might be used as a valuable pathological indicator for the carcinogenesis and progression of colorectal carcinomas.
authors.affiliation: Department of Pathology, First Military Medical University, Guangzhou 510515, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: Yan-qing
authors.initials: YQ
authors.lastname: Ding
authors.forename: Hong-jun
authors.initials: HJ
authors.lastname: Yang
authors.forename: Jin-hua
authors.initials: JH
authors.lastname: Zhang
authors.forename: Ai-bao
authors.initials: AB
authors.lastname: Chen
mesh_terms: D002455:Cell Division; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D039081:Integrin alpha5beta1 / Q000032:analysis* / Q000502:physiology; D009362:Neoplasm Metastasis
chemical_list: D039081:Integrin alpha5beta1