title: Gliofibroma: a case report and review of the literature.
abstract: Gliofibroma is a rare astrocytic tumor, composed of a glial component ranging from benign to high grade of malignancy and a consistently benign mesenchymal component. Its exact biological behavior is not fully known. In addition, histogenesis and prognostic factors are also still debatable. We herein present a rare case of gliofibroma in a 25-yr-old male with seizure. A computed tomographic scan of the brain showed a 1.5 cm-sized, enhancing mass with calcification. Histologically, the tumor consisted of glial fibrillary acidic protein (GFAP)-positive glial cells admixed with a mesenchymal component and extensive collagen lay down. The glial cells displayed variable cellularity, but without mitosis or necrosis. Since the MIB-1 labeling index was up to 35.8% in the cellular areas of the glial component, it could be considered to be a predictor of worse prognosis.
authors.affiliation: Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Yoonjung
authors.initials: Y
authors.lastname: Kim
authors.forename: Yeon Lim
authors.initials: YL
authors.lastname: Suh
authors.forename: Changohk
authors.initials: C
authors.lastname: Sung
authors.forename: Seung Chyul
authors.initials: SC
authors.lastname: Hong
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000175:diagnosis* / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000096:biosynthesis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008938:Mitosis; D009336:Necrosis; D011379:Prognosis; D012640:Seizures / Q000150:complications; D014057:Tomography, X-Ray Computed
chemical_list: D005904:Glial Fibrillary Acidic Protein