Apolipoprotein E genotype in patients with Alzheimer's disease.
OBJECTIVE
To explore the frequency and significance of ApoE gene polymorphisms in patients with sporadic Alzheimer's disease (AD).


METHODS
Single nucleotide polymorphisms of the ApoE gene were analyzed in 32 cases of AD and 26 controls, using PCR and gene sequencing.


RESULTS
The single nucleotide polymorphism of ApoE gene 462C/G was significantly associated with AD (P < 0.05).


CONCLUSIONS
The 462C/G polymorphism might be a specific genotype in Chinese patients with sporadic AD.
Luo
Benyan
B
Department of Neurology, First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310003, China. lobenyan@263.net
Chen
Zhi
Z
Zhang
Yanyan
Y
Pan
Xiaoping
X
Li
Xia
X
Chen
Feng
F
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E