[Successful treatment with foscarnet for disseminated varicella-zoster infection after reduced intensity stem cell transplantation in a case of relapsed refractory central nervous system lymphoma].
Visceral disseminated varicella-zoster virus (VZV) infection occurred with acute graft-versus-host disease in a 33-year-old Japanese male with non-Hodgkin lymphoma who had undergone allogeneic stem cell transplantation from an HLA-identical sibling after reduced intensity conditioning chemotherapy. Although ganciclovir and acyclovir treatment was effective temporarily, the number of VZV-DNA copies in the blood remained at a high level, and the hepatitis was prolonged. The patient was treated with foscarnet, which led to improvement of the VZV viremia and the hepatic dysfunction. Foscarnet therapy should be considered for acyclovir-resistant VZV infection in the setting of allogeneic hematopoietic stem cell transplantation.
Aoyama
Yasutaka
Y
Graduate School of Medicine, Osaka City University.
Yamamura
Ryousuke
R
Shima
Etsuko
E
Nakamae
Hirohisa
H
Makita
Kaori
K
Hasegawa
Taro
T
Sakamoto
Chikahiko
C
Terada
Yoshiki
Y
Kho
Genzyu
G
Ohta
Kensuke
K
Yamane
Takahisa
T
Takubo
Takayuki
T
Hino
Masayuki
M
D000212:Acyclovir / Q000494:pharmacology; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D016543:Central Nervous System Neoplasms / Q000150:complications / Q000628:therapy*; D024882:Drug Resistance, Viral; D017245:Foscarnet / Q000627:therapeutic use*; D006086:Graft vs Host Disease / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006562:Herpes Zoster / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000628:therapy*; D008297:Male; D012008:Recurrence; D014184:Transplantation, Homologous
D000998:Antiviral Agents; D017245:Foscarnet; D000212:Acyclovir