Tc-99m ciprofloxacin imaging in diagnosis of chronic bacterial prostatitis.
OBJECTIVE
To investigate the value of Tc-99m ciprofloxacin imaging in the differential diagnosis of chronic bacterial prostatitis.


METHODS
The study included 4 normal subjects as the negative controls, 2 patients with acute prostatitis or cystourethritis as the positive controls and 59 patients diagnosed as chronic bacterial prostatitis or chronic pelvic pain syndrome by traditional laboratory tests. In every subject, the single photon emission computerized tomography images were obtained 3 h after intravenous injection of Tc-99m Ciprofloxacin. The results of the imaging were compared with those of laboratory tests.


RESULTS
On the images, negative uptake was observed in all normal subjects, while strong hot uptake, in the whole prostate of acute prostatitis patients and in the whole urethra of acute cystourethritis patients. In 13 (68%) of 19 patients categorized as chronic bacterial prostatitis by standard laboratory tests, hot uptake with less intensity than that of acute prostatitis was observed in the prostate area around the prostatic urethra. Negative uptake in the prostate was observed in 6 of 19 patients (32%) categorized as chronic bacterial prostatitis. Interestingly, hot uptake in the prostate was exhibited in 28 (70%) of the 40 patients categorized as chronic pelvic pain syndrome.


CONCLUSIONS
Tc-99m ciprofloxacin imaging is helpful in the differential diagnosis of prostatitis syndrome.
Ryu
Ji-Kan
JK
Department of Nuclear Medicine, Inha University School of Medicine, Incheon 400103, Korea.
Lee
Seong-Min
SM
Seong
Do-Whan
DW
Suh
Jun-Kyu
JK
Kim
Sungeun
S
Choe
Wonsick
W
Moon
Yeonsook
Y
Pai
Soo-Hwan
SH
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000000981:diagnostic imaging* / Q000382:microbiology; D002908:Chronic Disease; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D017699:Pelvic Pain / Q000000981:diagnostic imaging; D011472:Prostatitis / Q000000981:diagnostic imaging* / Q000382:microbiology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014526:Urethritis / Q000000981:diagnostic imaging
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C431804:Technetium Tc 99m ciprofloxacin; D002939:Ciprofloxacin