Accelerated memory decline in Alzheimer's disease with apolipoprotein epsilon4 allele.
To investigate a possible effect of the apolipoprotein (APOE) epsilon4 allele on memory decline in Alzheimer's disease (AD), we examined 64 AD patients with the APOE epsilon3/3, epsilon3/4, or epsilon4/4 allele using the Alzheimer Disease Assessment Scale-Cognitive subscale (ADAS-Cog) and its subtests at the initial examination and at the 1-year follow-up visit. One-year changes in the scores of the Word Recall subtest, Word Recognition subtest, and total ADAS-Cog were significantly correlated with the number of APOE epsilon4 alleles after controlling for the effects of age, sex, education, test interval, and baseline scores. Findings revealed that APOE epsilon4 allele is related to an accelerated memory decline in AD.
Hirono
Nobutsugu
N
Department of Clinical Neurosciences and Basic Neurosciences, Faculty of Health Sciences, Ehime University School of Medicine, Japan. hirono@m.ehime-u.ac.jp
Hashimoto
Mamoru
M
Yasuda
Minoru
M
Kazui
Hirokazu
H
Mori
Etsuro
E
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000097:blood / Q000150:complications* / Q000235:genetics / Q000378:metabolism; D001057:Apolipoproteins E / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
D001057:Apolipoproteins E; D012333:RNA, Messenger