title: Molecular diversity through sugar scaffolds.
abstract: Monosaccharides provide an excellent platform to tailor molecular diversity by appending desired substituents at selected positions around the sugar scaffold. The presence of five functionalized and stereo-controlled centres on the sugar scaffolds gives the chemist plenty of scope to custom design molecules to a pharmacophore model. This review focuses on the peptidomimetic developments in this area, as well as the concept of tailoring structural and functional diversity in a library using carbohydrate scaffolds and how this can lead to increased hit rates and rapid identification of leads, which has promising prospects for drug development.
authors.affiliation: Alchemia Pty Ltd, 3 Hi-Tech Court, Brisbane Technology Park, Eight Mile Plains QLD 4113, Australia. WMeutermans@alchemia.com.au
authors.forename: Giang Thanh
authors.initials: GT
authors.lastname: Le
authors.forename: Giovanni
authors.initials: G
authors.lastname: Abbenante
authors.forename: Bernd
authors.initials: B
authors.lastname: Becker
authors.forename: Matthias
authors.initials: M
authors.lastname: Grathwohl
authors.forename: Judy
authors.initials: J
authors.lastname: Halliday
authors.forename: Gerry
authors.initials: G
authors.lastname: Tometzki
authors.forename: Johannes
authors.initials: J
authors.lastname: Zuegg
authors.forename: Wim
authors.initials: W
authors.lastname: Meutermans
mesh_terms: D000818:Animals; D002241:Carbohydrates / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D002241:Carbohydrates