title: Serological analysis of human leukocyte antigens-A and -B antigens in Thai patients with nasopharyngeal carcinoma.
abstract: OBJECTIVE
  To study the distribution of human leukocyte antigens (HLA) -A and -B antigens by standard microlymphocytotoxicity assay in Thai nasopharyngeal carcinoma (NPC) patients compared to normal controls in order to identify the alleles associated with NPC in Thailand.
  
  
  METHODS
  Retrospective-Analytical study.
  
  
  METHODS
  Fifty-three unrelated Thai patients with histologically confirmed NPC diagnosed at King Chulalongkorn Memorial Hospital and 70 healthy unrelated Thai individuals served as controls.
  
  
  METHODS
  Lymphocyte separation and HLA typing were performed from freshly drawn blood by standard microlymphocytotoxicity assay. The significance of differences between the two groups was analyzed by the chi-square test.
  
  
  RESULTS
  HLA-A2 was observed at a greater frequency in patients being found in 31/53 (58%) NPC patients compared to 27/70 (38%) controls (p = 0.02). An increase in HLA-B46 was also demonstrated. HLA-B46 was present in 16/53 (30%) NPC patients but was observed in 10/70 (14%) in controls (p = 0.03).
  
  
  CONCLUSIONS
  This study reported two susceptible, HLA-A2 and HLA-B46 antigens, for NPC in a Thai population.
authors.affiliation: Immunology Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Nattiya
authors.initials: N
authors.lastname: Pimtanothai
authors.forename: Oratai
authors.initials: O
authors.lastname: Kangwanshiratada
authors.forename: Preeyachit
authors.initials: P
authors.lastname: Charoenwongse
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000097:blood* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D015234:HLA-A Antigens / Q000097:blood* / Q000235:genetics*; D015235:HLA-B Antigens / Q000097:blood* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000097:blood* / Q000235:genetics*; D013785:Thailand
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens