Are follicular dendritic cells really good for nothing?
Follicular dendritic cells (FDCs), which reside in the primary B-cell follicles and germinal centres of lymphoid tissues, can sequester antigen in the form of immune complexes and are thought to be pivotal to the germinal-centre reaction and the maintenance of immunological memory. But, many recent studies question the importance of FDCs and their bound immune complexes in B-cell responses. This article asks whether we can truly rule out a requirement for these cells in host defence.
Kosco-Vilbois
Marie H
MH
NovImmune S.A., 64 Avenue de la Roseraie, CH-1205 Geneva, Switzerland. mkosco-vilbois@novimmune.com
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D017209:Apoptosis / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D020566:Dendritic Cells, Follicular / Q000166:cytology / Q000276:immunology*; D018858:Germinal Center / Q000166:cytology / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000276:immunology
D000936:Antigen-Antibody Complex; D011947:Receptors, Antigen, B-Cell