Dietary CLA and DHA modify skin properties in mice.
This study investigated the influence of PUFA on the properties of mouse skin. Mice (3 wk old) were given free access to oils high in linoleic acid, CLA, or DHA for 4 wk. At the end of the experiment, their skins were compared by both biochemical and histological methods. No significant differences in lipid and collagen contents were detected among treatments, although the FA composition in the skin was altered depending upon the FA composition of the supplemented oils. Electron microscopy revealed that the subcutaneous tissue layers in the CLA and DHA groups were significantly thinner than that in the high linoleic acid group, whereas no differences in the thickness of dermis layers were observed among the three groups. These results suggest that skin properties in mice are readily modified by dietary FA sources within 4 wk of dietary oil supplementation.
Oikawa
Daichi
D
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Nakanishi
Tomonori
T
Nakamura
Yoshinori
Y
Takahashi
Yukiko
Y
Yamamoto
Takaya
T
Shiba
Nobuya
N
Tobisa
Manabu
M
Takagi
Tomo
T
Iwamoto
Hisao
H
Tachibana
Tetsuya
T
Furuse
Mitsuhiro
M
D017667:Adipocytes / Q000166:cytology / Q000187:drug effects; D000818:Animals; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D012867:Skin / Q000187:drug effects* / Q000378:metabolism* / Q000648:ultrastructure; D040521:Subcutaneous Tissue / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure
D044243:Linoleic Acids, Conjugated; D004281:Docosahexaenoic Acids