title: Effects of hypertonic saline, HAES and dimethylsulphoxide on free oxygen radicals in haemorrhagic shock oxygen radicals in haemorrhagic shock.
abstract: BACKGROUND
  The aim of this study was to investigate the effects of antioxidant and resuscitation fluids which were used during haemorrhagic shock on tissue ischemia.
  
  
  METHODS
  Forty New Zealand type rabbits were divided into four groups as C (control), I (hypertonic saline), H (HAES) and D (Dimethylsulphoxide-DMSO). Haemorrhagic shock was induced by bleeding from carotid artery. Thirty minutes after shock, Group C was not resuscitated while Group I was resuscitated with Hypertonic saline 7.2, Group H with 10 % HAES and Group D with HAES 10 % and DMSO. Thiobarbituric acid reactive substances (TBARS) and lactate levels in blood, liver and small bowel samples were measured.
  
  
  RESULTS
  There were no significant differences among the groups tissue and plasma TBARS and lactate levels.
  
  
  CONCLUSIONS
  Resuscitation fluids and addition of antioxidants to the resuscitation fluids do not have any superiorities over each other to prevent tissue ischemic insult in haemorrhagic shock.
authors.affiliation: Meram Medical Faculty of Selçuk University Emergency Department, Merman University Experimental Medicine and Research Center, 42080 Merman/Konya. a_bayir@hotmail.com
authors.forename: Aysegül
authors.initials: A
authors.lastname: Bayir
authors.forename: M Ertuğrul
authors.initials: ME
authors.lastname: Kafali
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ak
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sahin
authors.forename: Emrah
authors.initials: E
authors.lastname: Karagözoğlu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gül
authors.forename: Kaan
authors.initials: K
authors.lastname: Karabulut
mesh_terms: D000818:Animals; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000378:metabolism; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D007421:Intestine, Small / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D011817:Rabbits; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000628:therapy*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D016166:Free Radical Scavengers; D012462:Saline Solution, Hypertonic; D017392:Thiobarbituric Acid Reactive Substances; D019344:Lactic Acid; D004121:Dimethyl Sulfoxide