Cytosine analogues from substituted acetonitriles via Thorpe condensation.
[reaction: see text] A Thorpe condensation is the key bond construction in a rapid and efficient synthesis of substituted cytosine derivatives from readily available starting materials.
Barkin
Julia L
JL
Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
Faust
Marcus D
MD
Trenkle
William C
WC
D000097:Acetonitriles / Q000737:chemistry*; D000215:Acylation; D003500:Cyclization; D003596:Cytosine / Q000031:analogs & derivatives*; D004987:Ethers / Q000737:chemistry; D017953:Isocyanates / Q000737:chemistry; D015394:Molecular Structure; D011743:Pyrimidines / Q000737:chemistry
D000097:Acetonitriles; D004987:Ethers; D017953:Isocyanates; D011743:Pyrimidines; D003596:Cytosine