Phenolic constituents from Dalbergia cochinchinensis.
Three new phenolic compounds (1-3), along with five known phenolics, 4'-hydroxy-2'-methoxychalcone (4), latinone (5), dalbergiphenol (6), 7-hydroxyflavanone, and dalbergin (7), have been isolated from the stems of Dalbergia cochinchinensis. The structures of 1-3 were established by spectroscopic techniques including 1D and 2D NMR methods. The inhibitory activity against testosterone 5 alpha-reductase, which causes androgen-dependent diseases, was also examined for selected compounds.
Shirota
Osamu
O
Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. shirota@nihs.go.jp
Pathak
Vibha
V
Sekita
Setsuko
S
Satake
Motoyoshi
M
Nagashima
Yoshio
Y
Hirayama
Yutaka
Y
Hakamata
Yusuke
Y
Hayashi
Tatsuo
T
D058891:5-alpha Reductase Inhibitors; D000726:Androgen Antagonists / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035782:Dalbergia / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014744:Vietnam
D058891:5-alpha Reductase Inhibitors; D000726:Androgen Antagonists; D010636:Phenols