title: Intravenous infusion of recombinant tissue plasminogen activator for the treatment of patients with sudden and/or chronic hearing loss.
abstract: Seventeen patients with sudden hearing loss and 10 patients with chronic hearing loss were treated with intravenous infusion of tissue plasminogen activator. For sudden hearing loss, the recombinant tissue plasminogen activator was used, and 3 mg (in 3 mL of diluent) was diluted into 250 mL of physiological saline solution and given intravenously every 12 hours. Sixteen patients of the sudden hearing loss group and all 10 patients of the chronic hearing loss group showed an improvement after this treatment. No patients had side effects from the treatment. The results indicate that this would be an excellent mode of therapy for patients with hearing loss.
authors.affiliation: Department of Otorhinolaryngology, University of Genoa, Genoa, Italy.
authors.forename: Renzo
authors.initials: R
authors.lastname: Mora
authors.forename: Marco
authors.initials: M
authors.lastname: Barbieri
authors.forename: Francesco
authors.initials: F
authors.lastname: Mora
authors.forename: Massimilliano
authors.initials: M
authors.lastname: Mora
authors.forename: T J
authors.initials: TJ
authors.lastname: Yoo
mesh_terms: D000367:Age Factors; D000704:Analysis of Variance; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005240:Feasibility Studies; D005340:Fibrinogen / Q000032:analysis; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D034381:Hearing Loss / Q000188:drug therapy*; D003639:Hearing Loss, Sudden / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D011516:Prothrombin / Q000032:analysis; D012044:Regression Analysis; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D011516:Prothrombin; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator