Bilateral subthalamic nucleus stimulation for the treatment of Parkinson's disease: results of six patients.
In this study, researchers evaluated the effect of bilateral subthalamic nucleus stimulation on various measures of Parkinson's disease. Assessments were completed before and after surgery in a double-blind fashion under the following six conditions: (a) on medication, (b) off medication, (c) on medication/on stimulation, (d) on medication/off stimulation, (e) off medication/on stimulation, and (f) off medication/off stimulation. On average, improvement was noted in all areas including the Unified Parkinson's Disease Rating Scale, Schwab and England Activities of Daily Living Scale, Modified Hoehn and Yahr Staging, and timed tests: In addition, dyskinesia duration and dyskinesia disability were reduced.
Eriksen
Sharon K
SK
Neurosurgical Associates, LTD, Minneapolis, MN, USA. sreriksen@aol.com
Tuite
Paul J
PJ
Maxwell
Robert E
RE
Sullivan
Mary
M
Low
Walter C
WC
Ebner
Timothy J
TJ
D000203:Activities of Daily Living; D000368:Aged; D004599:Electric Stimulation Therapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009722:Nurse Practitioners; D010300:Parkinson Disease / Q000534:rehabilitation / Q000601:surgery* / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000601:surgery*; D016896:Treatment Outcome