Height, body mass index, and ovarian cancer: a follow-up of 1.1 million Norwegian women.
Body mass index (BMI) has shown both positive and negative associations with ovarian cancer. Whether a possible association between height and ovarian cancer exists is unknown. We explored whether BMI and height were associated with ovarian cancer risk in a Norwegian cohort of approximately 1.1 million women, aged 14-74 years who were measured between 1963 and 1999. The cohort was followed for an average of 25 years through linkage to population-based cancer and death registries. Among the cohort, 7882 histologically verified cases of ovarian cancer were registered. Relative to women with a medium BMI (18.5-24.9 kg/m2), women who were overweight or obese in adolescence or young adulthood had an increased risk of ovarian cancer; women with a very high BMI in adolescence had a relative risk of 1.56 (95% confidence interval = 1.04 to 2.32) compared with women with medium BMI. No such association was seen in older women. A positive association between height and risk of ovarian cancer, particularly endometrioid ovarian cancer, was observed in women younger than 60 years of age.
Engeland
Anders
A
Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway. anders.engeland@fhi.no
Tretli
Steinar
S
Bjørge
Tone
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D001827:Body Height; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D009765:Obesity / Q000150:complications*; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012307:Risk Factors