title: Pharmacological evidence of the role of dorsal striatum in spatial memory consolidation in mice.
abstract: This study investigated the role of dorsal striatum in spatial memory in mice. The mice were tested for their ability to detect a spatial displacement 24 hr after training. In order to manipulate the dorsal striatum, focal administrations of the N-methyl-D-aspartate (NMDA) antagonist D-2-amino-5 phosphonopentanoic acid (AP-5) were performed immediately after training. AP-5 impaired the mice's ability to detect the spatial change only if their initial position was constant during training and testing. These findings demonstrate that NMDA receptor blockade within the dorsal striatum impairs spatial memory consolidation in a task in which no explicit reward or procedural learning is involved. The results are discussed with reference to a possible selective involvement of this structure in processing spatial information acquired through an egocentric, but not an allocentric, frame of reference.
authors.affiliation: Dipartimento di Genetica e Biologia Molecolare, Università degli Studi di Roma La Sapienza, Italy.
authors.forename: Elvira
authors.initials: E
authors.lastname: De Leonibus
authors.forename: Pauline
authors.initials: P
authors.lastname: Lafenetre
authors.forename: Alberto
authors.initials: A
authors.lastname: Oliverio
authors.forename: Andrea
authors.initials: A
authors.lastname: Mele
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D003342:Corpus Striatum / Q000502:physiology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D007858:Learning; D008297:Male; D008568:Memory / Q000502:physiology*; D051379:Mice; D013028:Space Perception
chemical_list: D018691:Excitatory Amino Acid Antagonists; D015763:2-Amino-5-phosphonovalerate