title: Ovarian hyperstimulation syndrome: strategies for prevention.
abstract: Ovarian hyperstimulation syndrome (OHSS) is a serious, iatrogenic complication of ovarian stimulation. The following report is a review of traditional and new strategies to prevent the development of OHSS. Techniques such as reducing the ovarian stimulus, coasting and cryopreservation are discussed. Other more investigative strategies are also summarized, including follicular aspiration, in-vitro maturation of immature oocytes, the use of gonadotrophin-releasing hormone (GnRH) agonists to trigger ovulation and the use of volume expanders such as hydroxyethyl starch. In addition, a review of the internal experience with OHSS at the authors' institution is described. All these preventative approaches are based on current understanding of the physiologic mechanisms involved in the pathogenesis of OHSS.
authors.affiliation: The Center for Reproductive Medicine and Infertility, Weill Cornell Medical College, 505 East 70th Street, HMT-340, New York, NY 10021, USA.
authors.forename: Dehan
authors.initials: D
authors.lastname: Chen
authors.forename: Lynn
authors.initials: L
authors.lastname: Burmeister
authors.forename: Dan
authors.initials: D
authors.lastname: Goldschlag
authors.forename: Zev
authors.initials: Z
authors.lastname: Rosenwaks
mesh_terms: D000418:Albumins / Q000378:metabolism*; D015925:Cryopreservation; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000378:metabolism; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D010062:Ovulation Induction / Q000009:adverse effects*; D011994:Recombinant Proteins / Q000378:metabolism; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000418:Albumins; D006895:Hydroxyethyl Starch Derivatives; D011994:Recombinant Proteins; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone