Malondialdehyde and nitric oxide levels in the plasma of patients with advanced laryngeal cancer.
OBJECTIVE
We investigated alterations in plasma nitrite, nitrate, total nitric oxide (NO*), and malondialdehyde (MDA) levels in patients with advanced stage laryngeal cancer.


METHODS
We measured the levels of MDA and total NO2-, as well as the NO3- marker for NO* generation, in 25 patients with advanced laryngeal cancer and 15 healthy control subjects.


RESULTS
The levels of plasma MDA, NO*, and NO3- were significantly higher in the patients with laryngeal cancer than in the healthy controls (P < 0.001 for all). On the other hand, although plasma NO2- was increased in the patient group, the statistical difference was not significant (P > 0.05). Moreover, the MDA and NO* levels did not differ significantly between patients with stage III and stage IV laryngeal cancer.


CONCLUSIONS
These findings demonstrate that oxidative stress is increased in patients with advanced laryngeal cancer.
Taysi
Seyithan
S
Department of Biochemistry, School of Medicine, Atatürk University, Medical School, 25240 Erzurum, Turkey.
Uslu
Celil
C
Akcay
Fatih
F
Sutbeyaz
Mehmet Yavuz
MY
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D009367:Neoplasm Staging; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000097:blood*; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress
D014408:Biomarkers, Tumor; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D008315:Malondialdehyde