Chelation-control in nucleophilic addition to Cr(CO)3-complexed aryl aldehydes.
One or more methoxy groups on the benzylic carbon at the ortho-position of tricarbonylchromium-complexed aryl aldehydes (2, 3 or 4) permit chelation-controlled addition of nucleophiles to the carbonyl function in the presence of Lewis acids. In the absence of a Lewis acid additive, a complementary set of diastereomeric products are obtained.
Tipparaju
Suresh Kumar
SK
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411 008, India.
Puranik
Vedavati G
VG
Sarkar
Amitabha
A