[Pathologic diagnosis of primary small round cell tumors of the bone].
OBJECTIVE
To study the diagnosis and differentiation of primary small round cell tumors of bone.


METHODS
Thirty-nine cases were studied by light microscopy and immunochemistry of O13, NSE, S-100, Actin and LCA.


RESULTS
20/22 cases of EW/PNET were positive for O13.16/22 cases of EW/PNET and one case of small cell osteosarcoma were positive for NSE. S-100 was positive in EW/PNET, small cell osteosarcoma and mesenchymal chondrosarcoma. All malignant lymphomas were positive for LCA. 6 cases of small cell osteosarcoma have osteoid production. Islands of cartilage were found in mesenchymal chondrosarcoma.


CONCLUSIONS
O13 is a specific valuable marker for the diagnosis of EW/PNET. Histologic features of the osteoid in osteosarcoma and the cartilage in mesenchymal chondrosarcoma are important for the diagnosis.
Na
Jia
J
Department of Pathology, Peking University First Hospital, Beijing 100034, China. jna4495@hotmail.com
Zou
Wanzhong
W
Fang
Zhiwei
Z
Zhang
Ying
Y
D000293:Adolescent; D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis; D001859:Bone Neoplasms / Q000737:chemistry / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018242:Neuroectodermal Tumors, Primitive / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012512:Sarcoma, Ewing / Q000473:pathology*
D000951:Antigens, Neoplasm; C062335:HBA-71 tumor antigen; D010751:Phosphopyruvate Hydratase