title: Correlation of photosensitizer delivery to lipoproteins and efficacy in tumor and arthritis mouse models; comparison of lipid-based and Pluronic P123 formulations.
abstract: OBJECTIVE
  The purpose of this study was the use of animal models to demonstrate the importance of drug delivery (verteporfin) to plasma lipoproteins in order to attain efficacy of photodynamic therapy (PDT) in vivo.
  
  
  METHODS
  Photosensitizers appropriately formulated in various vehicles such as pluronics and lipid-based systems were compared to delivery of the drug in DMSO in two in vivo systems. The first was a tumor model using male DBA/2 mice inoculated intradermally with M1 rhabdomyosarcoma cells and in the second, arthritis in the MRL -lpr mouse strain was enhanced by two intradermal injections of complete Freunds adjunct.
  
  
  RESULTS
  Those formulations in which the drug was in a monomeric form were better able to transfer drug to lipoproteins, which in turn led to superior PDT in vivo.
  
  
  CONCLUSIONS
  The ability to introduce drug in monomeric form into the circulation correlates well with efficacy of photosensitizer formulations in mouse arthritis and tumor models.
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Rubinah K
authors.initials: RK
authors.lastname: Chowdhary
authors.forename: Isha
authors.initials: I
authors.lastname: Sharif
authors.forename: Namrata
authors.initials: N
authors.lastname: Chansarkar
authors.forename: David
authors.initials: D
authors.lastname: Dolphin
authors.forename: Leslie
authors.initials: L
authors.lastname: Ratkay
authors.forename: Sean
authors.initials: S
authors.lastname: Delaney
authors.forename: Howard
authors.initials: H
authors.lastname: Meadows
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D010949:Plasma / Q000378:metabolism
chemical_list: D008074:Lipoproteins; D017319:Photosensitizing Agents