Synthesis of substituted p-stereogenic vinylphosphine oxides by olefin cross-metathesis.
[reaction: see text] Substituted vinylphosphine oxides have been prepared in good yield and exclusive (E)-olefin selectivity via olefin cross-metathesis using Grubbs and Hoveyda-type ruthenium catalysts. In addition, metathesis of chiral vinylphosphine oxides proceeds without racemization of the phosphorus chirality center, providing easy access to functionalized chiral nonracemic (E)-alkenylphosphine oxides.
Demchuk
Oleg M
OM
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
Pietrusiewicz
K Michał
KM
Michrowska
Anna
A
Grela
Karol
K