[A hypothesis about anti-DNA antibody].
"Anti-DNA antibody" is the antibody which can bind DNA molecules. It is well accepted that this antibody, especially in anti-double strand DNA antibody, has a high disease specificity for SLE. Usually, the antibody is detected by using DNA molecule as a binding target in the clinical laboratory test performed in vitro. However, it is quite unknown what the antibody is actually attacking in vivo. This review will introduce many findings known to date and try to solve the mystery of anti-DNA antibody with a hypothesis that the antibody nonspecifically crossreacts to negatively charged substances(e.g., polysaccharides) in vivo. Probably, a type of charge interaction is dominantly involved in this binding.
Tajima
Yutaka
Y
Clinical Laboratory, Saga Medical School Hospital, Saga 849-8501.
D001323:Autoantibodies / Q000276:immunology*; D003429:Cross Reactions; D004247:DNA / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology
D001323:Autoantibodies; D004247:DNA