title: Effects of beta-sheet breaker peptide polymers on scrapie-infected mouse neuroblastoma cells and their affinities to prion protein fragment PrP(81-145).
abstract: The effects of Soto's 'beta-sheet breaker peptide' and its polymer on PrPSc formation in ScN2a cells were investigated. Surface plasmon resonance study indicated that direct binding between PrP(81-145) and the 'beta-sheet breaker peptide' is not specific and may not play a major role in the inhibition of PrPSc formation.
authors.affiliation: Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
authors.forename: Takehisa
authors.initials: T
authors.lastname: Oishi
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Hagiwara
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kinumi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamakawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nishijima
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Arimoto
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001704:Biopolymers / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data; D009447:Neuroblastoma / Q000378:metabolism* / Q000473:pathology; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D018620:PrPSc Proteins / Q000472:pathogenicity*; D011328:Prions / Q000737:chemistry / Q000378:metabolism*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D020349:Surface Plasmon Resonance; D014407:Tumor Cells, Cultured
chemical_list: D001704:Biopolymers; D010446:Peptide Fragments; D010455:Peptides; D018620:PrPSc Proteins; D011328:Prions