title: No evidence of skin infection with Chlamydia pneumoniae in patients with cutaneous T cell lymphoma.
abstract: Recently, Chlamydia pneumoniae-specific DNA and antigens were reported in the skin of patients with Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphomas. In order to revalidate these data we analyzed skin sections of patients with MF for the expression of three different chlamydial antigens and C. pneumoniae DNA by immunohistochemistry and PCR according to previously described protocolls. Neither C. pneumoniae-specific DNA sequences nor antigens were detected in any of the skin biopses from 24 MF patients tested, suggesting that further studies are needed to establish any pathogenetic relevance of C. pneumoniae in MF.
authors.affiliation: Department of Dermatology, The Saarland University Hospital, Homburg/Saar, Germany.
authors.forename: M J
authors.initials: MJ
authors.lastname: Rössler
authors.forename: G
authors.initials: G
authors.lastname: Rappl
authors.forename: M
authors.initials: M
authors.lastname: Muche
authors.forename: D O
authors.initials: DO
authors.lastname: Hasselmann
authors.forename: W
authors.initials: W
authors.lastname: Sterry
authors.forename: W
authors.initials: W
authors.lastname: Tilgen
authors.forename: U
authors.initials: U
authors.lastname: Reinhold
mesh_terms: D000328:Adult; D000368:Aged; D023521:Chlamydophila Infections / Q000503:physiopathology*; D016993:Chlamydophila pneumoniae; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000382:microbiology / Q000503:physiopathology*