title: Cytotoxic naphthoquinones from roots of Lippia microphylla.
abstract: A new prenylated naphthoquinone dimer named microphyllaquinone (1), a mixture of 6-methoxy- and 7-methoxy-naphtho[2,3-b]-furan-4,9-quinones (2a/2b) and tecomaquinone I (3), were isolated from roots of Lippia microphylla. The structures were elucidated by spectroscopic methods, including detailed 1D and 2D (COSY, NOESY, HMQC, HMBC) NMR data. Unpublished 13C NMR data of 2a and 2b are reported. The in vitro cytotoxic activity of the isolated compounds was tested against five types of tumor cells.
authors.affiliation: Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, CP 12200, 60451-970 Fortaleza, Ceará, Brazil.
authors.forename: Hélcio S
authors.initials: HS
authors.lastname: Santos
authors.forename: Sônia M O
authors.initials: SM
authors.lastname: Costa
authors.forename: Otília D L
authors.initials: OD
authors.lastname: Pessoa
authors.forename: Manoel O
authors.initials: MO
authors.lastname: Moraes
authors.forename: Claudia
authors.initials: C
authors.lastname: Pessoa
authors.forename: Sergio
authors.initials: S
authors.lastname: Fortier
authors.forename: Edilberto R
authors.initials: ER
authors.lastname: Silveira
authors.forename: Telma L G
authors.initials: TL
authors.lastname: Lemos
mesh_terms: D000818:Animals; D001943:Breast Neoplasms; D002470:Cell Survival / Q000187:drug effects*; D003110:Colonic Neoplasms; D005260:Female; D018922:HL-60 Cells; D006801:Humans; D032411:Lippia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008546:Melanoma, Experimental; D051379:Mice; D009285:Naphthoquinones / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry*; D010947:Plants, Toxic / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D009285:Naphthoquinones; D010936:Plant Extracts