Psychoactive compounds and their antibodies: effect on self-stimulation of the lateral hypothalamus in morphinized rats.
We studied the effect of morphine hydrochloride, brain-specific S100 protein, and antibodies to morphine, S100 protein, and opiate mu-receptors in ultralow doses on self-stimulation of the lateral hypothalamus in morphinized rats. This reaction in morphine-withdrawn rats underwent specific changes after single administration of test preparations. Repeated treatment with preparations in the same dose equalized emotional homeostasis. This effect was especially pronounced after treatment with antibodies to morphine, S100 protein, and opiate mu-receptors. Our findings should be taken into account in developing methods for non-narcotic substitutive therapy of patients with morphine dependence.
Epstein
O I
OI
Institute of Neurology, Psychiatrics, and Narcology, Ukrainian Academy of Medical Sciences, Kharkov.
Vorob'eva
T M
TM
Geiko
V V
VV
Berchenko
O G
OG
D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D007026:Hypothalamic Area, Lateral / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009021:Morphine Dependence; D051381:Rats; D017450:Receptors, Opioid, mu / Q000276:immunology; D009418:S100 Proteins / Q000276:immunology; D012653:Self Stimulation / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome
D000701:Analgesics, Opioid; D000906:Antibodies; D017450:Receptors, Opioid, mu; D009418:S100 Proteins; D009020:Morphine