title: Potentiated antibodies to mu-opiate receptors: effect on integrative activity of the brain.
abstract: The effect of homeopathically potentiated antibodies to mu-receptors (10(-100) wt %) on integrative activity of rat brain was studied using the models of self-stimulation of the lateral hypothalamus and convulsions produced by electric current. Electric current was delivered through electrodes implanted into the ventromedial hypothalamus. Single treatment with potentiated antibodies to mu-receptors increased the rate of self-stimulation and decreased the threshold of convulsive seizures. Administration of these antibodies for 7 days led to further activation of the positive reinforcement system and decrease in seizure thresholds. Distilled water did not change the rate of self-stimulation and seizure threshold.
authors.affiliation: Institute of Neurology, Psychiatrics, and Narcology, Ukrainian Academy of Medical Sciences, Kharkov.
authors.forename: V V
authors.initials: VV
authors.lastname: Geiko
authors.forename: T M
authors.initials: TM
authors.lastname: Vorob'eva
authors.forename: O G
authors.initials: OG
authors.lastname: Berchenko
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D009292:Narcotic Antagonists; D051381:Rats; D011957:Receptors, Opioid / Q000276:immunology; D012640:Seizures / Q000188:drug therapy; D012653:Self Stimulation / Q000187:drug effects*
chemical_list: D000906:Antibodies; D009292:Narcotic Antagonists; D011957:Receptors, Opioid