title: [Successful treatment of refractory peripheral T-cell lymphoma by allogeneic peripheral blood stem cell transplantation].
abstract: A 40-year-old man was admitted to our hospital suffering from abdominal pain. He revealed marked splenomegaly, lymphadenopathy and pancytopenia. Lymph node biopsy showed diffuse proliferation of medium to large atypical lymphoid cells. Immunohistochemically the cells were positive for T-cell markers. He was diagnosed as having peripheral T cell lymphoma (PTCL) with involvement of the spleen and bone marrow. Because of refractoriness to combination chemotherapies and splenic irradiation, we performed allogeneic peripheral blood stem cell transplantation from an HLA-identical sister. Conditioning was consisted of conventional doses of total body irradiation and cyclophosphamide, and GVHD prophylaxis was performed with cyclosporine and methotrexate. After the patient developed grade III graft-versus-host disease, his splenomegaly improved dramatically. Although the effectiveness of allogeneic hematopoietic cell transplantation in the treatment of malignant lymphoma is controversial, we should consider this as a second-line therapy to refractory subsets of PTCL.
authors.affiliation: Department of Rheumatology and Medicine, Medical Institute of Bioregulation, Kyushu University.
authors.forename: Motoaki
authors.initials: M
authors.lastname: Shiratsuchi
authors.forename: Satoru
authors.initials: S
authors.lastname: Suehiro
authors.forename: Youko
authors.initials: Y
authors.lastname: Suehiro
authors.forename: Kenzaburo
authors.initials: K
authors.lastname: Tani
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shiokawa
authors.forename: Junji
authors.initials: J
authors.lastname: Nishimura
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000628:therapy*; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous
chemical_list: D016572:Cyclosporine