Neurotropic compounds and their antibodies: effect on the brain system of positive emotional reinforcement.
We studied the effects of ethanol, morphine, S100 protein, and antibodies to morphine, S100 protein, and opiate  -receptors in ultralow doses on self-stimulation of the lateral hypothalamus. The reaction underwent similar changes after single administration of test preparations. Tenfold treatment produced the stimulatory and stabilizing effect, which was related to ambivalent properties of preparations in ultralow doses. Tenfold administration of water did not produce changes in control animals.
Epstein
O I
OI
Materia Medica Holding Research-and-Production Company, Moscow.
Vorob'eva
T M
TM
Geiko
V V
VV
Pan
I R
IR
Berchenko
O G
OG
D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D007026:Hypothalamic Area, Lateral / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000276:immunology / Q000494:pharmacology*; D051381:Rats; D017450:Receptors, Opioid, mu / Q000276:immunology; D009418:S100 Proteins / Q000276:immunology / Q000494:pharmacology; D012653:Self Stimulation / Q000187:drug effects
D000906:Antibodies; D017450:Receptors, Opioid, mu; D009418:S100 Proteins; D000431:Ethanol; D009020:Morphine