[Isotype switching of produced immunoglobulins in multiple myeloma].
Multiple myeloma is usually characterized by production of a single serum monoclonal protein of constant isotype and light chain restriction. Isotype switching in human lymphomas appears to be an uncommon event. It could be due to altered para-protein production by the malignant plasma cell clone, or oligoclonal Ig production during recovery of B-cell function after chemotherapy. We describe a case of clonal heavy chain isotype switching in a patient with lymphoplasmocytic lymphoma.
Drobiecki
Arkadiusz
A
Dział Onkohematologii Swietokrzyskiego Centrum Onkologii w Kielcach, 25-734 Kielce, ul. Artwińskiego 3.
Kisiel
Elzbieta
E
Wasińska
Ewa
E
D000368:Aged; D006801:Humans; D017578:Immunoglobulin Class Switching; D007143:Immunoglobulin Heavy Chains / Q000378:metabolism*; D007132:Immunoglobulin Isotypes / Q000378:metabolism*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology* / Q000473:pathology; D008297:Male; D009101:Multiple Myeloma / Q000276:immunology
D007143:Immunoglobulin Heavy Chains; D007132:Immunoglobulin Isotypes