title: Trophic factors in neurodegenerative disorders.
abstract: Neuronal survival is dependent on continuous trophic stimulation by neurotrophic factors. Anterograde and retrograde transport of neurotrophic factors and their receptors within neurites is essential for the communication of these survival signals. Lack of neurotrophic input has been proposed as a pathomechanism leading to neurodegenerative disease. The present short review provides a summary of some of the recent data on neurotrophic factors in neurodegenerative disorders and describes how disturbances of axonal trafficking might deprive neurons from trophic input.
authors.affiliation: Division of Neuropathology, Institute of Pathology, University of Berne, CH-3010 Berne, Switzerland. joachim.weis@pathology.unibe.ch
authors.forename: Joachim
authors.initials: J
authors.lastname: Weis
authors.forename: Smita
authors.initials: S
authors.lastname: Saxena
authors.forename: Maria E
authors.initials: ME
authors.lastname: Evangelopoulos
authors.forename: Alex
authors.initials: A
authors.lastname: Kruttgen
mesh_terms: D000818:Animals; D002450:Cell Communication; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000473:pathology / Q000503:physiopathology*; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D006133:Growth Substances; D025801:Ubiquitin