Induction of T helper type 1 responses by a polysaccharide deacetylase from Cryptococcus neoformans.
A 25-kDa cryptococcal deacetylase (d25) was found here to induce cell proliferation, as well as secretion of interleukin 2 and gamma interferon, but not interleukin 4, in spleen cells from d25-immunized or Cryptococcus neoformans-infected mice. The gamma interferon, but not the interleukin 2, response was required for the protective activities of d25 immunization in a murine cryptococcosis model.
Biondo
Carmelo
C
Dipartimento di Patologia e Microbiologia Sperimentale, Facoltà di Medicina e Chirurgia, Università di Messina, I-98125 Messina, Italy.
Beninati
Concetta
C
Bombaci
Mauro
M
Messina
Luciano
L
Mancuso
Giuseppe
G
Midiri
Angelina
A
Galbo
Roberta
R
Teti
Giuseppe
G
D000581:Amidohydrolases / Q000737:chemistry / Q000276:immunology*; D000818:Animals; D003453:Cryptococcosis / Q000276:immunology / Q000517:prevention & control; D003455:Cryptococcus neoformans / Q000201:enzymology* / Q000276:immunology*; D005260:Female; D005656:Fungal Proteins / Q000737:chemistry / Q000276:immunology; D007371:Interferon-gamma / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics; D018664:Interleukin-12 / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D008970:Molecular Weight; D018417:Th1 Cells / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis
D005656:Fungal Proteins; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D018664:Interleukin-12; D007371:Interferon-gamma; D000581:Amidohydrolases; C022427:polysaccharide deacetylase