title: Tissue-equivalent materials for construction of tomographic dosimetry phantoms in pediatric radiology.
abstract: Tissue equivalent materials have a variety of uses, including routine quality assurance and quality control in both diagnostic and therapeutic physics. They are frequently used in a research capacity to measure doses delivered to patients undergoing various therapeutic procedures. However, very few tissue equivalent materials have been developed for research use at the low photon energies encountered in diagnostic radiology. In this paper, we present a series of tissue-equivalent (TE) materials designed to radiographically mimic human tissue at diagnostic photon energies. These tissue equivalent materials include STES-NB (newborn soft tissue substitute), BTES-NB (newborn bone tissue substitute), LTES (newborn as well as a child/adult lung tissue substitute), STES (child/adult soft tissue substitute), and BTES (child/adult bone tissue substitute). In all cases, targeted reference elemental compositions are taken from those specified in the ORNL stylized computational model series. For each material, reference values of mass density, mass attenuation coefficients (10-150 keV), and mass energy-absorption coefficients (10-150 keV) were matched as closely as permitted by material selection and manufacturing constraints. Values of mu/rho and mu(en)/rho for the newborn TE materials are noted to have maximum deviations from their ORNL reference values of from 0 to -3% and from +2% to -3%, respectively, over the diagnostic energy range 10-150 keV. For the child/adult TE materials, these same maximal deviations of mu/rho and mu(en)/rho are from +1.5% to -3% and from +3% to -3%, respectively. Simple calculations of x-ray fluence attenuation under narrow-beam geometry using a 66 kVp spectrum typical of newborn CR radiographs indicate that the tissue-equivalent materials presented here yield estimates of absorbed dose at depth to within 3.6% for STES-NB, 3.2% for BTES-NB, and 1.2% for LTES of the doses assigned to reference newborn soft, bone, and lung tissue, respectively.
authors.affiliation: Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida 32611-8300, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Jones
authors.forename: D E
authors.initials: DE
authors.lastname: Hintenlang
authors.forename: W E
authors.initials: WE
authors.lastname: Bolch
mesh_terms: D000328:Adult; D001842:Bone and Bones / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015233:Models, Statistical; D008962:Models, Theoretical; D009132:Muscles / Q000473:pathology; D019047:Phantoms, Imaging; D017785:Photons; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted; D014965:X-Rays