title: Synthesis of differentially protected/functionalised acetylenic building blocks from p-benzoquinone and their use in the synthesis of new enediynes.
abstract: Sequential addition of two different lithium acetylides to p-benzoquinone yielded diastereomeric mixtures of 1,4-diethynylcyclohexa-2,5-diene-1,4-diols wherein the two ethynyl groups bear different protective/functional groups. Selective deprotection to the terminal acetylene followed by Pd(0) mediated coupling with Z-1,2-dichloroethene yielded new enediynes bearing cyclohexa-2,5-diene units.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai-600 036, India. sanka@iitm.ac.in
authors.forename: Sethuraman
authors.initials: S
authors.lastname: Sankararaman
authors.forename: Manivannan
authors.initials: M
authors.lastname: Srinivasan