Reducing toxicity of cisplatin in cancer chemotherapy by extracorporeal removal of excess cisplatin.
Cisplatin and its derivatives are today among the most frequently used agents for treatment of malignancies, the dose, however, is limited by side effects. When an organ or extremity with tumor has a single, well defined artery, cisplatin can be delivered into the tumor, and cisplatin leaving the tumor through the venous drainage can be removed before it empties into the systemic circulation. We developed a hollow fiber device with an immobilized platinum chelator for extracorporeal removal of cisplatin, without the chelator entering the blood. When blood from melanoma patients, obtained during cisplatin infusion, was circulated through the device, 80% of the cisplatin was removed. In experiment using dogs cisplatin (100 mg/m2) was infused into the femoral vein, thus restricting cisplatin to the area to be treated. This method allows for applying high cisplatin doses locally, while reducing systemic side effects.
Ambruss
Clara M
CM
Kaleida Health System SUNY at Buffalo, Department of Medicine, Buffalo, NY, USA.
Karakousis
Constantine P
CP
Stadler
Agnes
A
Stadler
Istvan
I
Ambrus
Julian L
JL
Anthone
Sidney
S
Ambrus
Julian L
JL
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood / Q000302:isolation & purification*; D002614:Chelating Agents; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000295:instrumentation; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood / Q000302:isolation & purification*; D004285:Dogs; D005112:Extracorporeal Circulation / Q000295:instrumentation; D006464:Hemoperfusion / Q000295:instrumentation; D006801:Humans; D066298:In Vitro Techniques; D007261:Infusions, Intra-Arterial; D008545:Melanoma / Q000097:blood / Q000188:drug therapy; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy*
D000970:Antineoplastic Agents; D002614:Chelating Agents; D002945:Cisplatin