[Possible role of mucosal lymphocyte homing in the pathogenesis of extraintestinal manifestations in inflammatory bowel diseases].
Patients with inflammatory bowel disease are likely to develop several extraintestinal complications including skin, eye, joint or liver disorders. Some of them tend to correlate with underlying bowel inflammation or may run a chronic independent course from the bowel disease. Tissue infiltration with lymphocytes seems to be the most prominent feature of extraintestinal manifestations. Recent reports have suggested that these lymphocytes are originally activated in the inflamed bowel and then aberrantly recruited to sites outside the gut. Furthermore the hypothesized existence of an enterohepatic circulation of lymphocytes could also contribute to the pathogenesis of liver complications.
Müzes
Györgyi
G
Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Belgyógyászati Klinika, Budapest.
D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005128:Eye Diseases / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology*; D007592:Joint Diseases / Q000209:etiology / Q000503:physiopathology; D008107:Liver Diseases / Q000209:etiology / Q000503:physiopathology; D008214:Lymphocytes / Q000378:metabolism*; D009092:Mucous Membrane / Q000503:physiopathology; D016201:Receptors, Lymphocyte Homing / Q000378:metabolism*; D012871:Skin Diseases / Q000209:etiology / Q000503:physiopathology
D015815:Cell Adhesion Molecules; D016201:Receptors, Lymphocyte Homing