[Comparative kinetics of 3-hydroxyphenazepam and its metabolism during transdermal and intravenous administration].
The kinetics of excretion of 2-(14)C-3-hydroxyphenazepam and its metabolites were studied upon a single transdermal and intravenous administration in mice. The main fraction of the total radioactivity (approximately 80%) was eliminated within approximately 84 h upon intravenous injection and within approximately 360 h after transdermal introduction. In the latter case, the ratio of lipophilic and hydrophilic metabolites is modified as well: the former fraction increases by a factor of 1.75, while the latter decreases by a factor of 1.2 as compared to the case of intravenous drug administration.
Larionov
V B
VB
Odessa National University, Odessa, Ukraine.
Golovenko
N Ia
NIa
Kravchenko
I A
IA
Aleksandrova
A I
AI
Ovcharenko
N V
NV
D000279:Administration, Cutaneous; D000818:Animals; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D013693:Temazepam / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000652:urine*
D013693:Temazepam