title: Adult Langerhans cell histiocytosis limited to the skin.
abstract: BACKGROUND
  The incidence of Langerhans cell histiocytosis (LCH) is 4-5 per million in children with only 30% of this number having an adult onset. While dermatological manifestations occur in as many as 50% of cases, disease limited to the skin is uncommon among reported cases of adult LCH.
  
  
  OBJECTIVE
  To present 3 new cases of adult LCH and a review of the literature of isolated cutaneous LCH in adults.
  
  
  RESULTS
  Three adults with scalp, vulvar and generalized LCH lesions had refractory responses to treatment.
  
  
  CONCLUSIONS
  LCH may present with unusual cutaneous manifestations limited to the skin in adults. Optimal treatment has not yet been determined.
authors.affiliation: Department of Dermatology, University of Texas M.D. Anderson Cancer Center, Houston, Tex. 77030, USA. mduvic@mail.mdanderson.org
authors.forename: Asha
authors.initials: A
authors.lastname: Singh
authors.forename: Victor G
authors.initials: VG
authors.lastname: Prieto
authors.forename: Adam
authors.initials: A
authors.lastname: Czelusta
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: McClain
authors.forename: Madeleine
authors.initials: M
authors.lastname: Duvic
mesh_terms: D000328:Adult; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012535:Scalp / Q000473:pathology; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*; D014844:Vulva / Q000473:pathology