title: The effect of GHRH, GHRP-2 and somatostatin on GH secretion by fetal pituitary.
abstract: Growth hormone releasing peptide (GHRP-2) is a synthetic hexapeptide which specifically stimulates secretion of growth hormone (GH) by fetal pituitary somatotrophs through a new membrane receptor, which is different from growth hormone releasing hormone (GHRH) and somatostatin (SMS) receptors. We used cell cultures of human fetal pituitary somatotroph cells to investigate the effect of GHRH, GHRP-2 and somatostatin on GH secretion. The results showed that the mechanism of GHRH/SMS and GHRP-2 was different. This indicated that a different intracellular signal transduction system might also play a crucial role in the regulation of GH secretion.
authors.affiliation: Department of Pediatrics, Xiehe Hospital, Tongji Medical University, Wuhan 430022.
authors.forename: Q
authors.initials: Q
authors.lastname: Liu
authors.forename: X
authors.initials: X
authors.lastname: Bai
authors.forename: K
authors.initials: K
authors.lastname: Liu
authors.forename: W
authors.initials: W
authors.lastname: Lin
authors.forename: T
authors.initials: T
authors.lastname: Lei
mesh_terms: D005333:Fetus; D013007:Growth Hormone-Releasing Hormone / Q000502:physiology*; D006801:Humans; D009842:Oligopeptides / Q000502:physiology*; D010902:Pituitary Gland / Q000502:physiology*; D015398:Signal Transduction; D013004:Somatostatin; D052683:Somatotrophs
chemical_list: D009842:Oligopeptides; D013004:Somatostatin; D013007:Growth Hormone-Releasing Hormone; C091874:growth hormone-releasing peptide-2