title: Novel Pseudomonas aeruginosa gene that suppresses tolerance to carbapenems.
abstract: A biapenem-tolerant mutant of Pseudomonas aeruginosa was isolated by Tn1737KH insertion. The survival of the mutant 3 h after the addition of biapenem was about 1000 times greater than that of the wild type. The mutant was also tolerant to other biapenems, such as imipenem, panipenem, and meropenem.
authors.affiliation: Department of Microbiology, Tokushima University School of Dentistry, Tokushima 770-8504, Japan.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Taniguchi
authors.forename: Tsuneko
authors.initials: T
authors.lastname: Ono
authors.forename: Keiji
authors.initials: K
authors.lastname: Murakami
authors.forename: Darija
authors.initials: D
authors.lastname: Viducic
authors.forename: Sizuo
authors.initials: S
authors.lastname: Kayama
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Hirota
authors.forename: Ken
authors.initials: K
authors.lastname: Nemoto
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Miyake
mesh_terms: D000818:Animals; D015780:Carbapenems / Q000494:pharmacology*; D015169:Colony Count, Microbial; D017931:DNA Primers; D004251:DNA Transposable Elements / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics; D011550:Pseudomonas aeruginosa / Q000235:genetics*
chemical_list: D015780:Carbapenems; D017931:DNA Primers; D004251:DNA Transposable Elements