title: [A clinical study of hepatic arterial infusion chemotherapy with 5-FU and leucovorin for liver metastases].
abstract: We followed patients who underwent hepatic arterial infusion chemotherapy (HAI) with 5-FU and Leucovorin for liver metastases. Since CR (complete response) and PR (partial response) were achieved, this therapy seems to be effective. 5-FU metabolized on its first pass through the liver, and the hepatic extraction with rapid HAI is lower than that with slow HAI. It is suggested that control of extrahepatic lesions thought rapid HAI is useful for life prolongation.
authors.affiliation: Dept. of Surgery, Ogachi Central Hospital.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ichihara
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tenma
authors.forename: Manabu
authors.initials: M
authors.lastname: Itoh
authors.forename: Masanori
authors.initials: M
authors.lastname: Hibino
authors.forename: Isao
authors.initials: I
authors.lastname: Kikuchi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hosono
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D007261:Infusions, Intra-Arterial; D002955:Leucovorin / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male
chemical_list: D000964:Antimetabolites, Antineoplastic; D002955:Leucovorin; D005472:Fluorouracil