Effects of phenazepam in ultralow doses on bioelectric activity of the brain and behavior of rats in various models of anxiety.
Phenazepam in ultralow doses produced an anxiolytic effect on male outbred albino rats in the conflict situation and elevated plus-maze models and inhibited theta-activity in EEG, which is typical of tranquilizers. As differentiated from standard doses, phenazepam in this concentration did not affect other frequency bands. Our results suggest that phenazepam in ultralow doses acts as the anxioselective tranquilizer.
Voronina
T A
TA
Laboratory of Psychopharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences.
Molodavkin
G M
GM
Chernyavskaya
L I
LI
Seredenin
S B
SB
Burlakova
E B
EB
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy; D001522:Behavior, Animal / Q000187:drug effects*; D001569:Benzodiazepines / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004594:Electrophysiology; D008297:Male; D051381:Rats
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; C017928:phenazepam