title: Power thrombectomy in acute ischemic coronary syndromes.
abstract: Intracoronary thrombi are commonly found in patients with acute coronary syndromes. A large thrombus burden or a platelet-rich thrombus frequently resists pharmacologic therapy ("thrombolytic ceiling"). In such cases restoration of adequate antegrade coronary flow necessitates application of a mechanical force. Power thrombectomy is a revascularization strategy incorporating a mechanical device for removal of occlusive coronary thrombi in conjunction with or following administration of either platelet glycoprotein IIb/IIIa receptor inhibitors or thrombolytic agents, or both. Mechanical devices for power thrombectomy include ultrasound sonication, rheolytic thrombectomy (Angiojet), laser, transluminal extraction catheter, aspiration catheter, and to a limited extent, balloon angioplasty. In acute coronary syndromes the strategy of power thrombectomy aims to achieve the clinical advantages of more nearly complete vessel patency, improved antegrade flow, and enhanced preservation of myocardial tissue.
authors.affiliation: Cardiac Catheterization Laboratories, Division of Cardiology, Medical College of Virginia Hospital, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA 23249, USA.
authors.forename: On
authors.initials: O
authors.lastname: Topaz
authors.forename: Emerson C
authors.initials: EC
authors.lastname: Perin
authors.forename: Robert L
authors.initials: RL
authors.lastname: Jesse
authors.forename: Pramod K
authors.initials: PK
authors.lastname: Mohanty
authors.forename: Marc
authors.initials: M
authors.lastname: Carr
authors.forename: Uri
authors.initials: U
authors.lastname: Rosenschein
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D003328:Coronary Thrombosis / Q000150:complications / Q000601:surgery*; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology / Q000601:surgery*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors; D017131:Thrombectomy / Q000295:instrumentation / Q000379:methods
chemical_list: D005343:Fibrinolytic Agents; D019039:Platelet Glycoprotein GPIIb-IIIa Complex