title: [Study on the gene knockout model mice of Duchenne muscular dystrophy].
abstract: OBJECTIVE
  With a view to further experimental studies on Duchenne muscular dystrophy (DMD), we investigated the motor function, serum creatine kinase (CK) level and pathological characteristics of muscular tissue in C57, mdx, dystrophin/utrophin gene double knockout (dko)mice.
  
  
  METHODS
  Gene identification was performed for the filial generation of heterozygote of utrophin gene knockout of mdx mice for acquiring mdx and dko mice. The motor function, serum CK level, and the pathology of muscular tissue of C57, mdx and dko mice were compared.
  
  
  RESULTS
  There were significant differences in all detecting aspects between C57 mouse and dko mouse. In the aspects of serum CK level and pathology of muscular tissue, there were differences between C57 mouse and mdx mouse; however, no significant difference in motor function was observed between them.
  
  
  CONCLUSIONS
  Compared with mdx mouse, dko mouse is in a more serious illness state which is nearer to the natural state of DMD. Therefore, dko mouse is a more ideal model for studying the praxiology of DMD.
authors.affiliation: Department of Neurology, First Affiliated Hospital of Zhong Shan University, Guangzhou 510080, China.
authors.forename: Songlin
authors.initials: S
authors.lastname: Chen
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Gao
authors.forename: Weixi
authors.initials: W
authors.lastname: Zhang
authors.forename: Wen
authors.initials: W
authors.lastname: Huang
authors.forename: Xilin
authors.initials: X
authors.lastname: Lu
authors.forename: Zhanhang
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D003598:Cytoskeletal Proteins / Q000235:genetics; D004195:Disease Models, Animal; D016189:Dystrophin / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D018101:Mice, Inbred mdx; D018345:Mice, Knockout; D009043:Motor Activity / Q000502:physiology*; D020388:Muscular Dystrophy, Duchenne / Q000097:blood / Q000235:genetics / Q000503:physiopathology; D049411:Utrophin
chemical_list: D003598:Cytoskeletal Proteins; D016189:Dystrophin; D008565:Membrane Proteins; C483600:Utrn protein, mouse; D049411:Utrophin; D003402:Creatine Kinase