Isolation of new actinomycete strains for the screening of new bioactive compounds.
In order to facilitate the discovery of novel bioactive compounds from microorganisms, various techniques for isolation of new actinomycete strains have been attempted. Studies of the vertical distribution of actinomycetes in soil, isolation of actinomycetes from desert soils or fallen leaves, selective isolation of Kitasatospora strains using novobiocin or Actinoplanes strains using the chemotactic method, and the use of gellan gum as a solidifying agent were carried out. We discovered 9 novel bioactive compounds from actinomycete strains isolated under unusual conditions, and proposed two new genera, five new species and one new subspecies.
Takahashi
Yōko
Y
Kitasato Institute for Life Sciences, Kitasato University, and The Kitasato Institute, Minato-ku, Tokyo 108-8641, Japan. ytakaha@lisci.kitasato-u.ac.jp
Omura
Satoshi
S
D039903:Actinobacteria / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification*; D000595:Amino Acid Sequence; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology; D008969:Molecular Sequence Data; D010802:Phylogeny; D011135:Polysaccharides, Bacterial / Q000378:metabolism; D012988:Soil Microbiology
D000890:Anti-Infective Agents; D011135:Polysaccharides, Bacterial; C048288:gellan gum