title: [Elastase and alpha-1 proteinase inhibitor complex in broncho-alveolar lavage fluid in patients with bronchial asthma and sarcoidosis].
abstract: Forty-three patients were enrolled into this study, twenty-eight with sarcoidosis in various radiological stages (I, II, III) and activity of disease (active or non-active) and fifteen with bronchial asthma. Elastase and alpha 1-proteinase inhibitor complex (E-alpha 1IP) concentrations and percentage of neutrophils in broncho-alveolar lavage fluid (BALF) were measured in all groups of patients. There were no significant differences in E-alpha 1IP levels in patients with various activity of sarcoidosis. We noticed significant differences between radiological stages of sarcoidosis. E-alpha 1IP concentration in the pulmonary stage was significantly higher than in stage I hilar adenopathy and stage II hilar adenopathy plus pulmonary opacities. E-alpha 1IP concentrations in BALF were significantly higher in patients with bronchial asthma in comparison to patients with sarcoidosis.
authors.affiliation: Katedra i Klinika Chorób Płuc Akademii Medycznej we Wrocławiu.
authors.forename: Ewa
authors.initials: E
authors.lastname: Passowicz-Muszyńska
authors.forename: Renata
authors.initials: R
authors.lastname: Jankowska
authors.forename: Maryla
authors.initials: M
authors.lastname: Krasnowska
authors.forename: Marcin
authors.initials: M
authors.lastname: Gołecki
mesh_terms: D000328:Adult; D001249:Asthma / Q000188:drug therapy / Q000628:therapy*; D001982:Bronchial Diseases / Q000188:drug therapy / Q000628:therapy*; D018893:Bronchoalveolar Lavage / Q000379:methods*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D011480:Protease Inhibitors / Q000627:therapeutic use*; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins / Q000627:therapeutic use*; D012507:Sarcoidosis / Q000188:drug therapy / Q000628:therapy*
chemical_list: D011480:Protease Inhibitors; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins