title: Effect of active synthetic 2-substituted quinazolinones on anti-platelet aggregation and the inhibition of superoxide anion generation by neutrophils.
abstract: Quinazolinones, 2-substituted and 3-substituted, mainly synthesized by microwave irradiation, were subjected to anti-platelet aggregation and inhibition of superoxide anion generation assays. Interestingly, 2-phenyl-4-quinazolinone (4) exhibited significant inhibitory activities toward platelet aggregation and neutrophil activation, and it might therefore serve as a prototype lead compound.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Chin-Chung
authors.initials: CC
authors.lastname: Wu
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Ramesh
authors.initials: R
authors.lastname: Patnam
authors.forename: Reen-Yen
authors.initials: RY
authors.lastname: Kuo
authors.forename: Wei-Ya
authors.initials: WY
authors.lastname: Wang
authors.forename: Yu-Hsuan
authors.initials: YH
authors.lastname: Lan
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011799:Quinazolines / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D013481:Superoxides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D010975:Platelet Aggregation Inhibitors; D011799:Quinazolines; D013481:Superoxides