[Studies of heat shock protein 60 and heat shock protein 70 in oral lichen planus].
OBJECTIVE
To study the role of heat shock protein (HSP) 60 and HSP70 in the pathogenesis of oral lichen planus (OLP).


METHODS
The immunohistochemical SP methods were used to detected the expression of HSP60 and HSP70 in 62 cases of oral lichen planus, 10 cases of normal oral mucosa, 21 cases of chronic discoid lupus erythematosus (DLE), 10 cases of benign lymphoadenosis of mucosa, 46 cases of leukoplakia. RT-PCR was used to evaluate the expression of HSP60 mRNA and HSP70 mRNA in 12 cases of OLP and 5 cases of normal oral mucosa.


RESULTS
HSP60 was expressed at much higher levels in OLP than other groups. The expression of HSP70 decreased in epithelial cells in erosive lichen planus group. HSP60 mRNA and HSP70 mRNA were expressed at high level in OLP.


CONCLUSIONS
HSP60 and HSP70 play an important role in pathogenesis of OLP.
Di
Ping
P
Center of Implantation, Peking University School of Stomatology, Beijing 100081, China.
Gao
Yan
Y
D018834:Chaperonin 60 / Q000096:biosynthesis* / Q000235:genetics; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D017676:Lichen Planus, Oral / Q000378:metabolism* / Q000473:pathology; D009061:Mouth Mucosa / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis
D018834:Chaperonin 60; D018840:HSP70 Heat-Shock Proteins; D012333:RNA, Messenger