Qualitative platelet defect and thrombohaemorrhagic complications in a patient with polycythaemia vera. Case 10.
We describe a 67-year-old patient with polycythaemia vera and pathological functional platelet studies. He not only suffered a transient ischaemic attack despite taking of antiplatelet agents, but also showed bleeding diathesis with cerebral bleeding and spontaneous suffusions. Platelet function studies and clinical findings improved after phlebotomy and cytoreductive treatment with hydroxyurea. Thrombosis and haemorrhage account predominantly for morbidity and mortality in patients with polycythaemia vera. The pathophysiological mechanisms to explain thrombosis and bleeding in patients with myeloproliferative disorders including polycythaemia vera were intensively studied. However, up to now no clear correlation of laboratory findings in relation to clinical history of thrombosis and bleeding was demonstrated. In this report the most important pathophysiological mechanisms and therapy with antiplatelet agents are discussed.
Friess
D
D
Central Haematology Laboratory, Inselspital, University Hospital, 3010 Bern, Switzerland.
Lämmle
B
B
Alberio
L
L
D000368:Aged; D001241:Aspirin / Q000627:therapeutic use; D001791:Blood Platelet Disorders / Q000097:blood* / Q000188:drug therapy; D000077144:Clopidogrel; D006470:Hemorrhage / Q000097:blood; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D010979:Platelet Function Tests; D011087:Polycythemia Vera / Q000097:blood* / Q000150:complications*; D013927:Thrombosis / Q000097:blood; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin