Relation of albumin/creatinine ratio to C-reactive protein and to the metabolic syndrome.
We hypothesized that the association of high sensitivity C-reactive protein (CRP) with urinary albumin excretion (UAE) is predominately mediated through its correlation with the metabolic syndrome. Serum CRP and urine albumin:creatinine ratios (ACR) from 720 preventive cardiology patients were analyzed to estimate age- and gender-adjusted relative risk of high CRP and metabolic syndrome for high ACR. These data demonstrate that CRP independently predicts the presence of UAE, a marker of endothelial dysfunction.
Messerli
Adrian W
AW
Department of Preventive Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Seshadri
Niranjan
N
Pearce
Gregory L
GL
Sachar
Ravish
R
Hoogwerf
Byron J
BJ
Sprecher
Dennis L
DL
D000367:Age Factors; D000419:Albuminuria / Q000209:etiology / Q000652:urine*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002097:C-Reactive Protein / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D003327:Coronary Disease / Q000209:etiology / Q000517:prevention & control; D003404:Creatinine / Q000652:urine*; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications; D006973:Hypertension / Q000150:complications; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000652:urine*; D008875:Middle Aged; D012306:Risk; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012709:Serum Albumin; D012727:Sex Characteristics; D012907:Smoking / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D012709:Serum Albumin; D014280:Triglycerides; D002097:C-Reactive Protein; D003404:Creatinine