The relation between the clinical subtypes of delirium and the urinary level of 6-SMT.
Delirium is a common syndrome among hospitalized elderly patients. In humans, sleep and circadian rhythms are disturbed during delirium, and both are influenced by the hormone melatonin. This prompted us to investigate the relationship of the clinical subtypes of delirium: 1). hyperactive, 2). hypoactive, and 3). mixed, with melatonin, as reflected by a patient's urinary metabolite 6-SMT. Results support our hypothesis that urinary 6-SMT during delirium was higher in hypoactive and lower in hyperactive patients. Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.
Balan
Silviu
S
Shmuel Harofe Hospital, Geriatric Medical Center, Sackler School of Medicine, Tel-Aviv University, Beer Yacov, Israel. shmuelh@netvision.net.it
Leibovitz
Arthur
A
Zila
Shen Orr
SO
Ruth
Mishiev
M
Chana
Wechsler
W
Yassica
Blumenfeld
B
Rahel
Biton
B
Richard
Goldstein
G
Neumann
Elon
E
Blagman
Boris
B
Habot
Beni
B
D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D003693:Delirium / Q000145:classification / Q000652:urine*; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D038801:International Classification of Diseases; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives* / Q000652:urine*; D015999:Multivariate Analysis; D011569:Psychiatric Status Rating Scales; D011595:Psychomotor Agitation / Q000150:complications / Q000652:urine
C054513:6-sulfatoxymelatonin; D008550:Melatonin