Hypotensive effect of potentiated antibodies to angiotensin II and AT1 receptors.
Hypotensive activity of ultralow doses of antibodies to angiotensin II and its receptors was studied on adult NISAG rats with hereditary stress-induced arterial hypertension. Antibodies to C-terminal fragment of angiotensin II receptors produced the most pronounced hypotensive effect, which was reproducible after repeated administration. These antibodies decreased systolic blood pressure by 16.40 +/- 0.62 mm Hg. The most rapid hypotensive effect was produced by affinity purified antibodies to angiotensin II: 2 h after administration of these antibodies systolic blood pressure decreased by 12.80 +/- 5.49 mm Hg. Our results indicate that combination treatment with ultralow doses of antibodies to angiotensin II and its receptors hold much promise for the use in clinical practice.
Epstein
O I
OI
Materia Medica Holding Research-and-Production Company, Moscow.
Martyushev
A V
AV
Kudryashova
D R
DR
Markel
A L
AL
Sergeeva
S A
SA
Shtark
M B
MB
D000804:Angiotensin II / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000276:immunology / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D006973:Hypertension; D008297:Male; D051381:Rats; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology*
D000906:Antibodies; D000959:Antihypertensive Agents; D044140:Receptor, Angiotensin, Type 1; D000804:Angiotensin II