title: [Neutron-photon radiotherapy of brain tumors].
abstract: The data on combined photon-neutron radiation therapy of brain tumors (23 patients) are presented. Total focal dose (NSD) of photon radiation was 48-60 isoGy; neutron radiation--2.4 Gy (OBE equivalent to gamma radiation of 14.4 Gy). Out of 23 patients, 15 (65.2%) had suffered from tumor disease for a long time which continued after surgery or combined treatment, while 8 (34.8%) were followed up after treatment for primary brain tumor. First symptoms were evaluated. Dehydration therapy was given to 16 (69.6%). Photon- neutron radiation therapy follow-up was up 12 months. Immediate results were assessed every week. The number of complaints went down by approximately 12-15%; improvement was reported in 13 (56.5%), stabilization--9 (39.2%), deterioration--1 (4.8%). According to CT examination of the brain one month later, condition at focal site was unchanged in 17 (73.9%), 10% regression of tumor--6(26.1%). General aggravation of symptoms without roentgenological signs of tumor progression was registered in one case 3 months later. Brain tumor relapsed in still another patient 4 months later. All patients survived 12 months. These indices were 1.5-2 times higher than those for treatment of similar pathology using photon component alone.
authors.affiliation: Laboratory of Radiation Oncology, South Urals Research Center, Russian Academy of Medical Sciences.
authors.forename: A V
authors.initials: AV
authors.lastname: Vazhenin
authors.forename: A S
authors.initials: AS
authors.lastname: Domozhirova
authors.forename: M V
authors.initials: MV
authors.lastname: Vasil'chenko
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: Munasipov
authors.forename: G V
authors.initials: GV
authors.lastname: Mokichev
authors.forename: E P
authors.initials: EP
authors.lastname: Magda
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009502:Neutrons; D017785:Photons; D011878:Radiotherapy / Q000379:methods; D016019:Survival Analysis; D016896:Treatment Outcome