Antibodies to dopamine as neuromodulators of behavioral responses of mice of different genotypes.
The possibility of long-term changes in the innate characteristics of the behavior of mice of different genotypes (C57Bl/6 and BALB/c) after active immunization with dopamine-BSA conjugates was studied. These experiments revealed significant differences in the effects of anti-dopamine antibody on behavioral responses in an open field and neurotransmitter contents of brain structures in mice of different lines. Immunization with the dopamine-protein conjugate led to increases in the functional activity of the corresponding brain receptors, to different extents in mice of different lines.
Evseev
V A
VA
Science Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Mikovskaya
O I
OI
Vetrilé
L A
LA
Trekova
N A
NA
Basharova
L A
LA
Khlopushina
T G
TG
Gruden'
M A
MA
D000818:Animals; D000906:Antibodies / Q000378:metabolism / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D005838:Genotype; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009044:Motor Cortex / Q000187:drug effects / Q000378:metabolism; D015213:Neuroimmunomodulation; D011869:Radioligand Assay; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013003:Somatosensory Cortex / Q000187:drug effects / Q000378:metabolism; D014611:Vaccination
D000906:Antibodies; D017448:Receptors, Dopamine D2; D012710:Serum Albumin, Bovine; D012701:Serotonin; D004298:Dopamine