The tethered aminohydroxylation (TA) reaction.
Since Sharpless' discovery of the asymmetric aminohydroxylation (AA) reaction, a major challenge for chemists has been to find ways of controlling the regio- and stereochemical outcome of this important reaction. Detailed herein is a review of our novel approach towards gaining reliable and predictable regio- and stereocontrol through the use of a tethered carbamate to promote an intramolecular AA reaction, along with a description of the mechanism proposed for this new methodology.
Donohoe
Timothy J
TJ
The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, UK OX1 3QY. timothy.donohoe@chem.ox.ac.uk
Johnson
Peter D
PD
Pye
Richard J
RJ