Dacrymenone and VM 3298-2--new antibiotics with antibacterial and antifungal activity.
Two new antibiotic metabolites, dacrymenone (1) and VM 3298-2 (2), were isolated from fermentations of a Dacrymyces sp., and their structures were determined by spectroscopic techniques. Dacrymenone (1) is a new eremophilane sesquiterpenoid while VM 3298-2 (2) is a bis-enol ether between methyl pyruvate and 4,6-dihydroxycyclohexan-1,3-dione. Dacrymenone (1) shows weak antibacterial and antifungal activity while VM 3298-2 (2) exhibits cytotoxic and antifungal activities.
Mierau
Viktor
V
Lehrbereich Biotechnologie der Universität Kaiserslautern, Paul-Ehrlich-Str. 23, D-67663 Kaiserslautern, Germany.
Anke
Timm
T
Sterner
Olov
O
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects*; D001487:Basidiomycota / Q000737:chemistry* / Q000254:growth & development; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D007939:Leukemia L1210; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D015003:Yeasts / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C478006:VM 3298-2; C478005:dacrymenone