[Imbalance in the proteinase-inhibitor system in obstetric sepsis and septic shock].
The condition of proteinase-inhibitor balance was studied in blood plasma of patients with obstetric sepsis. Hypoproteinemia (due to a massive blood loss and toxic effect) was shown to result in a 2-5-fold decrease of the activity of endogenous proteinases in blood plasma versus the control group. The activity of alpha-macroglobulins was also by 2 times lower versus the controls, while the activity of alpha 1-antichymotrypsin and of an acid-stable inhibitor of trypsin was found to be higher by 20-30%. A degree of imbalance of proteinase/inhibitor depends on a disease severity.
Belova
L A
LA
Ogloblina
O G
OG
Satalkin
A A
AA
Diugeev
A N
AN
Fomin
M D
MD
Kashina
L G
LG
Kukharchuk
V V
VV
D010450:Endopeptidases / Q000097:blood*; D005260:Female; D006801:Humans; D007744:Obstetric Labor Complications / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011480:Protease Inhibitors / Q000378:metabolism*; D018805:Sepsis / Q000097:blood / Q000175:diagnosis*; D012772:Shock, Septic / Q000097:blood / Q000175:diagnosis; D000514:alpha 1-Antichymotrypsin / Q000097:blood; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
D011480:Protease Inhibitors; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D010450:Endopeptidases