Nonsense-mediated decay breaks the circle?
This Commentary discusses new data from the laboratory of Matthias Hentze (Schell et al., in this issue) that begins to dissect the RNA-protein and protein-protein interactions important for the process of nonsense-mediated decay (NMD). Schell and co-workers have developed a novel tool for analysis of such interactions in vivo. Using a proteomics approach, they have identified two different protein-RNA complexes that contain human Upf (up-frameshift) proteins central to the NMD process. Intriguingly, they identified a poly[A]-binding protein associated with these complexes.
Graham
Sheila V
SV
Institute of Biomedical and Life Sciences, Division of Virology, University of Glasgow, UK. gbga69@udcf.gla.ac.uk
D018389:Codon, Nonsense / Q000235:genetics* / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics; D020871:RNA Stability / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D018389:Codon, Nonsense; D012333:RNA, Messenger