Behavioral effects of potentiated antibodies to morphine and mu-opioid receptors during withdrawal syndrome.
We studied the effects of potentiated antibodies to morphine and mu-opioid receptors on animal behavior in the forced swimming test and reaction of light avoidance after morphine withdrawal. Antibodies to morphine normalized behavioral characteristics in the forced swimming test, while antibodies to mu-opioid receptors reduced dark preference in animals.
Pavlov
I F
IF
Institute of Molecular Biology and Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Epstein
O I
OI
Shtark
M B
MB
D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors* / Q000276:immunology; D009021:Morphine Dependence; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors* / Q000276:immunology; D013375:Substance Withdrawal Syndrome
D000906:Antibodies; D017450:Receptors, Opioid, mu; D009020:Morphine