6-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).
A novel series of 6-aryl-pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3).
Witherington
Jason
J
Department of Medicinal Chemistry, Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Research Limited, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. jason_witherington@gsk.com
Bordas
Vincent
V
Gaiba
Alessandra
A
Garton
Neil S
NS
Naylor
Antoinette
A
Rawlings
Anthony D
AD
Slingsby
Brian P
BP
Smith
David G
DG
Takle
Andrew K
AK
Ward
Robert W
RW
D000818:Animals; D001665:Binding Sites; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors*; D006801:Humans; D020128:Inhibitory Concentration 50; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014867:Water
D004791:Enzyme Inhibitors; D011725:Pyridines; D014867:Water; D038362:Glycogen Synthase Kinase 3