title: Physicochemical characterization and dissolution properties of nimesulide-cyclodextrin binary systems.
abstract: The objective of this work is physicochemical characterization of nimesulide-cyclodextrin binary systems both in solution and solid state and to improve the dissolution properties of nimesulide (N) via complexation with alpha-, beta, and gamma-cyclodextrins (CDs). Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1H nuclear magnetic resonance (1H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro dissolution studies. Phase solubility, mass spectrometry and 1H-NMR studies in solution revealed 1:1 M complexation of N with all CDs. A true inclusion of N with beta-CD at 1:2 M in solid state was confirmed by DSC, powder X-RD and SEM studies. Dissolution properties of N-CD binary systems were superior when compared to pure N.
authors.affiliation: Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India. buchi999@yahoo.com
authors.forename: Buchi N
authors.initials: BN
authors.lastname: Nalluri
authors.forename: K P R
authors.initials: KP
authors.lastname: Chowdary
authors.forename: K V R
authors.initials: KV
authors.lastname: Murthy
authors.forename: A R
authors.initials: AR
authors.lastname: Hayman
authors.forename: G
authors.initials: G
authors.lastname: Becket
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003505:Cyclodextrins / Q000737:chemistry*; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D013449:Sulfonamides / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003505:Cyclodextrins; D046911:Macromolecular Substances; D013449:Sulfonamides; C012655:nimesulide