title: Traceless solid phase synthesis of 2-substituted pyrimidines using an 'off-the-shelf' chlorogermane-functionalised resin.
abstract: The parallel solid phase synthesis of an 18-member library of 2-substituted pyrimidines is described using a chlorogermane-functionalised resin. The success of the key Pinner-type condensations between a resin-bound enaminone and an array of amidine hydrochlorides highlights the stability of arylgermane linkers (cf. arylsilanes) towards strongly basic/nucleophilic conditions.
authors.affiliation: Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, Yorkshire, UK S3 7HF. a.c.spivey@imperial.ac.uk
authors.forename: Alan C
authors.initials: AC
authors.lastname: Spivey
authors.forename: Ratnasothy
authors.initials: R
authors.lastname: Srikaran
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Diaper
authors.forename: David J
authors.initials: DJ
authors.lastname: Turner