Flecainide induced ventricular tachycardia (torsades de pointes).
This case report describes a 68-year-old woman presenting with flecainide induced syncope due to torsades de pointes (TP) ventricular tachycardia. Before TP onset, the QTc interval reached 680 ms without changes in QRS duration. None of the usual triggers were found. Prolongation of QT under flecaïnide is exceptional and the occurrence of TP without concurrent triggers has not been reported in the literature.
Thevenin
Jerome
J
Division of Cardiology, University Jean Monnet of Saint-Etienne, France.
Da Costa
Antoine
A
Roche
Frederic
F
Romeyer
Cecile
C
Messier
Marc
M
Isaaz
Karl
K
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D005424:Flecainide / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D016171:Torsades de Pointes / Q000139:chemically induced*
D000889:Anti-Arrhythmia Agents; D005424:Flecainide