title: Picket and other fences in biological membranes.
abstract: Nakada et al. revisit the controversial question of whether membrane lipids are able to diffuse from the axon of a neuron into the soma. Using single molecule imaging of a fluorescent phospholipid, the authors show that a diffusion barrier in the axon initial segment blocks the diffusion of lipids.
authors.affiliation: Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Boiko
authors.forename: Bettina
authors.initials: B
authors.lastname: Winckler
mesh_terms: D000818:Animals; D004058:Diffusion; D005456:Fluorescent Dyes / Q000378:metabolism; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism; D015222:Sodium Channels / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D008563:Membrane Lipids; D010743:Phospholipids; D015222:Sodium Channels