[Cyto-oxidant markers of inflammation in assessing the efficacy of differentiating therapy of severe obstructive pulmonary diseases].
The study purpose was the cytooxidant properties of inflammation in patients with severe heterogenic forms of chronic obstructive pulmonary disease (COPD); and the informative value of the changes in the studied indices for assessment of anti-inflammatory efficiency of differential therapy. The cytological test (CT) and chemiluminescent biotesting of bronchial lavage (CB) obtained with fibrobronchoscopy were conducted in 155 patients with severe bronchial asthma and chronic obstructive bronchitis. The patients were divided into groups according to current classification and predominant etiological factor of the exacerbation. The data of CT and CB in exacerbation significantly differ from the findings in the control group. They also differed in bronchial asthma and chronic obstructive bronchitis. The differentiated treatment resulted in improvement but did not reach the parameters of the control group. Thus, changes in CT and CB proved to be of the differentiated nature and this enables to use the tests as additional sensitive examinations in clinical practice.
Grinshteĭn
Iu I
IuI
Shestovitskiĭ
V A
VA
Kuligina-Maksimova
A V
AV
Cherkashina
I I
II
Aristov
A I
AI
D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers / Q000737:chemistry*; D029481:Bronchitis, Chronic / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D016896:Treatment Outcome
D015415:Biomarkers