title: Splenic vascular tumors.
abstract: Splenic vascular tumors are uncommon and are more typically encountered as benign incidental findings. By contrast, splenic angiosarcoma may present acutely and dramatically and typically pursues a very aggressive clinical course. Vascular tumors in the spleen may show conventional endothelial, specialized endothelial (sinusoidal/littoral cell) or lymphatic differentiation and there is morphologic overlap between some of the currently defined diagnostic categories, within which benign, intermediate, and malignant subsets are recognized. The greatest problem in trying to better define and analyze these tumors is the availability of only relatively small case numbers. This overview describes the diagnosis and differential diagnosis of splenic vascular tumors as presently understood.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Jeffery L
authors.initials: JL
authors.lastname: Kutok
authors.forename: Christopher D M
authors.initials: CD
authors.lastname: Fletcher
mesh_terms: D006390:Hemangioendothelioma / Q000473:pathology; D006391:Hemangioma / Q000473:pathology; D006394:Hemangiosarcoma / Q000473:pathology; D006801:Humans; D008202:Lymphangioma / Q000473:pathology; D009383:Neoplasms, Vascular Tissue / Q000473:pathology*; D013160:Splenic Neoplasms / Q000473:pathology*