title: [Stability evaluation of thymopentin in preparation process].
abstract: OBJECTIVE
  To observe whether thymopentin is stable in the preparation process.
  
  
  METHODS
  Using HPLC method, we investigated the influence of different temperature, sonification time and pH value on thymopentin.
  
  
  RESULTS
  The optimum storage condition for preservation of thymopentin was found to be a freezing environment. Thymopentin would not be degraded in the water bath of 60 degrees C for 24 hours or in different phosphate buffer solution (PBS) (pH 2, 5, 5, 7) under 37 degrees C for 24 hours. The sonification time within 15 minutes was determined to be safe for the preparation.
  
  
  CONCLUSIONS
  The experiment result indicates that thymopentin is stable during the whole preparation process.
authors.affiliation: Department of Pharmaceutics, West China Pharmacy School, Sichuan University, Chengdu 610041, China.
authors.forename: Weiling
authors.initials: W
authors.lastname: He
authors.forename: Zhirong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xuehua
authors.initials: X
authors.lastname: Jiang
authors.forename: Yu
authors.initials: Y
authors.lastname: Nie
authors.forename: Fang
authors.initials: F
authors.lastname: Wu
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003080:Cold Temperature; D004355:Drug Stability; D013678:Technology, Pharmaceutical; D013696:Temperature; D016305:Thymopentin / Q000032:analysis*; D013946:Thymopoietins / Q000138:chemical synthesis
chemical_list: D013946:Thymopoietins; D016305:Thymopentin