[Preliminary evaluation on the effects of a hybrid bioartificial liver support system in the treatment of hepatic failure].
OBJECTIVE
To construct a novel hybrid artificial liver support system and evaluate its clinical efficacy in the treatment of hepatic failure.


METHODS
A hybrid bioartificial liver support system consisting of plasma exchange device, charcoal perfusion column, and bioreactor cultured human or porcine hepatocytes was developed. 30 patients with hepatic failure were treated using this hybrid system.


RESULTS
Both the excellent rate and effectual rate of the artificial liver support system were 43.3% (13/30). The total effectual rate was 86.7%. Finally, eleven out of 30 patients recovered completely. Six patients were bridged to liver transplantation. Six patients (20%) died of hepatic failure and seven patients (23.3%) discharged due to worsening of disease.


CONCLUSIONS
The hybrid artificial liver support system has prominent liver support effects for hepatic failure, which can be regarded as an efficient measure for the treatment of severe hepatitis.
Wang
Ying-jie
YJ
Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
He
Nian-hai
NH
Niu
Run-zhang
RZ
Liu
Jun
J
Wen
Hong-wei
HW
Li
Jia-jia
JJ
Wang
Yu-ming
YM
D000328:Adult; D019149:Bioreactors; D002478:Cells, Cultured; D002606:Charcoal; D005260:Female; D006440:Hemofiltration / Q000295:instrumentation / Q000379:methods; D006464:Hemoperfusion / Q000295:instrumentation / Q000379:methods; D022781:Hepatocytes / Q000166:cytology; D006801:Humans; D017114:Liver Failure, Acute / Q000503:physiopathology / Q000628:therapy*; D019164:Liver, Artificial; D008297:Male; D008875:Middle Aged; D016060:Sorption Detoxification / Q000295:instrumentation / Q000379:methods; D016896:Treatment Outcome
D002606:Charcoal