title: [Determination of sulfamethoxazole in compound sulfamethoxazole tablet by first derivative ratio spectrometry].
abstract: The first derivative ratio spectrometry is used for the determination of sulfamethoxazole in compound sulfamethoxazole tablet. According to the first derivative ratio spectrum of sulfamethoxazole, peak-zero method is applied for the determination at 251 nm. There is a good linear correlation between the first derivative ratio spectrum value and concentration (1-15 micrograms.mL-1) for the method that can eliminate the disturbance of trimethoprim, and no difference while comparing the method with pharmacopoeia method (P > 0.05).
authors.affiliation: No. 1 Hospital of Lianyungang, Jiangsu, Lianyungang 222002.
authors.forename: Z
authors.initials: Z
authors.lastname: Sun
authors.forename: R
authors.initials: R
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: K
authors.initials: K
authors.lastname: Wang
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Zhou
mesh_terms: D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013420:Sulfamethoxazole / Q000032:analysis*; D013607:Tablets; D014295:Trimethoprim / Q000032:analysis; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000737:chemistry*
chemical_list: D013607:Tablets; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole