The etiology of neural tube defects: the role of folic acid.
CONCLUSIONS
While the cause of neural tube defects in humans is considered to be multifactorial, it is apparent that folic acid can prevent 70% of open neural tube defects. Even in laboratory animals with known genetic defects, folic acid can prevent the genetic expression.


CONCLUSIONS
While some of the metabolic pathways for folic acid are known, the true effects of folic acid on closure of the neural tube have yet to be discovered.
McLone
David G
DG
Division of Neurological Surgery, The Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614, USA. dmclone@nwu.edu
D005260:Female; D005333:Fetus; D005492:Folic Acid / Q000097:blood / Q000627:therapeutic use*; D006397:Hematinics / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D009436:Neural Tube Defects / Q000196:embryology / Q000209:etiology* / Q000517:prevention & control*; D011247:Pregnancy; D011295:Prenatal Care; D012307:Risk Factors
D006397:Hematinics; D005492:Folic Acid