Nitration of 2'-deoxyguanosine by a NO/O2 gas mixture: identification and characterization of N2-nitro-2'-deoxyguanosine.
[reaction: see text] A gas mixture of NO and O(2) was bubbled into 2'-deoxyguanosine solution at neutral pH and 37 degrees C. A novel nitrated nucleoside was generated in the reaction mixture in addition to 8-nitroguanine, 8-nitroxanthine, 2'-deoxyxanthosine, xanthine, and guanine. The novel nucleoside was identified as N(2)-nitro-2'-deoxyguanosine by spectrometric data.
Yamada
Masaki
M
Institute of Advanced Energy, Kyoto University, Uji 611-0011, Japan.
Suzuki
Toshinori
T
Kanaori
Kenji
K
Tajima
Kunihiko
K
Sakamoto
Shunji
S
Kodaki
Tsutomu
T
Makino
Keisuke
K
D003849:Deoxyguanosine / Q000031:analogs & derivatives*; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009566:Nitrates / Q000737:chemistry*; D009569:Nitric Oxide; D009705:Nucleosides / Q000737:chemistry; D010100:Oxygen; D019820:Xanthine / Q000737:chemistry; D014970:Xanthines / Q000737:chemistry
C432525:8-Nitroxanthine; C095838:8-nitroguanine; D009566:Nitrates; D009705:Nucleosides; D014970:Xanthines; D019820:Xanthine; D009569:Nitric Oxide; D006147:Guanine; D003849:Deoxyguanosine; D010100:Oxygen