title: [Effect of chronic ethanol consumption on basic carboxypeptidase activity in regions of the rat brain].
abstract: It is discovered that chronic consumption of ethanol induced decrease of carboxypeptidase H activity in striatum by 27%; increase of carboxypeptidase M activity in hippocampus by 67% and decrease in cerebral hemispheres by 34%; phenylmethylsulfonyl fluoride-inhibited carboxypeptidase activity increase in hypothalamus by 141%, in striatum by 60% and in optic and lamina quadrigemina by 34%. The role of basic carboxypeptidases in mechanisms of ethanol influence on the peptidergic systems are discussed.
authors.affiliation: Penza State Pedagogical University, Russia.
authors.forename: A  N
authors.initials: A
authors.lastname: Vernigora
authors.forename: O E
authors.initials: OE
authors.lastname: Mikhaĭlova
authors.forename: M T
authors.initials: MT
authors.lastname: Gengin
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Ryzhkova
authors.forename: E S
authors.initials: ES
authors.lastname: Mukhina
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D043423:Carboxypeptidase H / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D000431:Ethanol / Q000633:toxicity*; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology; D007031:Hypothalamus / Q000187:drug effects / Q000201:enzymology; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology; D051381:Rats; D013687:Telencephalon / Q000187:drug effects / Q000201:enzymology
chemical_list: D004791:Enzyme Inhibitors; D000431:Ethanol; D010664:Phenylmethylsulfonyl Fluoride; D043423:Carboxypeptidase H