c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis.
c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II, which is required for the transition from initiation to elongation of eukaryotic transcription. Inhibiting P-TEFb blocks the transcription of its target genes as well as cellular proliferation and apoptosis induced by c-Myc.
Kanazawa
Satoshi
S
Departments of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143-0703, USA.
Soucek
Laura
L
Evan
Gerard
G
Okamoto
Takashi
T
Peterlin
B Matija
BM
D000818:Animals; D017209:Apoptosis; D019556:COS Cells; D002455:Cell Division; D016259:Genes, myc / Q000502:physiology*; D042925:Positive Transcriptional Elongation Factor B; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D014158:Transcription, Genetic
D042925:Positive Transcriptional Elongation Factor B; D017346:Protein Serine-Threonine Kinases