title: Efficacy of linezolid alone or in combination with vancomycin for treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus.
abstract: The levels of effectiveness of linezolid, vancomycin, and the combination of linezolid and vancomycin were compared in the rabbit model of endocarditis caused by a clinical methicillin-resistant Staphylococcus aureus (MRSA) isolate. Vancomycin alone was more effective than either linezolid alone or the combination of linezolid and vancomycin for the treatment of endocarditis due to MRSA.
authors.affiliation: Division of Infectious Disease, Virginia Commonwealth University Health Systemthe, Richmond, Virginia, USA.
authors.forename: Fu-Yu
authors.initials: FY
authors.lastname: Chiang
authors.forename: Michael
authors.initials: M
authors.lastname: Climo
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001021:Aortic Valve / Q000382:microbiology; D015169:Colony Count, Microbial; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D007668:Kidney / Q000382:microbiology; D000069349:Linezolid; D018942:Macrolides; D016106:Methicillin Resistance / Q000235:genetics*; D023303:Oxazolidinones / Q000627:therapeutic use*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus; D014640:Vancomycin / Q000627:therapeutic use*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D018942:Macrolides; D023303:Oxazolidinones; D014640:Vancomycin; D000069349:Linezolid