title: Haploid allele mapping of Y-chromosome minisatellite, MSY1 (DYF155S1), to a Japanese population.
abstract: The present study analyses the human Y-chromosome minisatellite locus, MSY1 (DYF155S1), in 205 Japanese males of 191 pedigrees using the minisatellite variant repeat (MVR) mapping system. The internal haploid structures of the detected alleles considerably varied and consisted of three major repeat units: types 2, 3 and 4. A comparison of the haploid profiles of the MVR codes identified 185 distinct alleles, of which only five were shared. We did not detect a type 1 repeat unit, and variations were frequent at the 5' end of the minisatellite locus. Within an analysis of 24 paternally linked DNA samples donated by ten families, no mutational events were identified even over two generation gaps. Furthermore, we applied this mapping system to a paternity test in which the alleged father was missing.
authors.affiliation: Department of Forensic Medicine, Tokai University School of Medicine, Kanagawa 259-1193, Isehara, Japan.
authors.forename: Zheng-Bin
authors.initials: ZB
authors.lastname: Jin
authors.forename: Xiu-Lin
authors.initials: XL
authors.lastname: Huang
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakajima
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yukawa
authors.forename: Motoki
authors.initials: M
authors.lastname: Osawa
authors.forename: Sanae
authors.initials: S
authors.lastname: Takeichi
mesh_terms: D000483:Alleles; D041322:Chromosomes, Human, Y / Q000235:genetics*; D006238:Haploidy; D006801:Humans; D007564:Japan; D008297:Male; D018598:Minisatellite Repeats; D009154:Mutation; D010334:Paternity