title: [Controversies in the conduction and evaluation of clinical trials results for the treatment in vasovagal syncope].
abstract: The vasovagal syncope is a reflex reaction to various stimuli leading to the marked hypotension with or without bradycardia with loss of consciousness and fall of postural muscle tone. The vast majority of the patients recover spontaneously but if the syncope occurs frequently and causes injury of the patients body it worsens the quality of life and needs appropriate treatment. The injuries requiring hospitalization occur approximately in 10% of the patients with vasovagal syncope. The aim of the therapy of affected patients is to diminish the syncope prevalence, to brake the neurocardiogenic reaction on an early stage or to prolong the duration of the presyncope phase to enable the patient prevention of the injury. The lack of clear diagnostic criteria and difficulties with estimation the efficacy of any particular therapeutic intervention in many clinical studies of different authors, inclusion to the studies patients with different clinical presentation stages of the disease contribute to different conclusions, which automatic use in the clinical practice is inappropriate. There is an urgent need to clear the methodological discrepancies and to conduct good planed, large, randomized, multicentre studies to assess the efficacy of different therapeutic methods in the treatment of vasovagal syncope.
authors.affiliation: Katedra i Klinika Kardiologii Akademii Medycznej we Wrocławiu.
authors.forename: Jacek
authors.initials: J
authors.lastname: Gajek
authors.forename: Dorota
authors.initials: D
authors.lastname: Zyśko
authors.forename: Bogumił
authors.initials: B
authors.lastname: Halawa
mesh_terms: D005069:Evaluation Studies as Topic; D006801:Humans; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic / Q000592:standards*; D019462:Syncope, Vasovagal / Q000628:therapy*