[Nasal remodeling in patient with perennial allergic rhinitis].
BACKGROUND
Remodeling is considered a new or different reconstruction of tissues. The airway remodeling is a consequence of changes induced by endothelial cells and extra-cellular matrix as a result of chronic inflammation.


OBJECTIVE
To show histological changes into mucosa in patients with perennial allergic rhinitis.


METHODS
We studied 26 patients with perennial allergic rhinitis, with evolution of 3 to 6 years, between 20 to 40 years old, without medical or immunological treatment. A turbinate biopsy was taken in all of them.


RESULTS
We found enlargement of the basal membrane in 92.3%, subepithelial fibrosis in 92.4%, neutrophils in 100% of the cases, eosinophils in 100%, lymphocytes in 100%, edema in 46.2%, fragmented reticular fibers in 19.2%, and vascular dilatation in 11.1%.


CONCLUSIONS
These results suggest nasal remodeling in patients with allergic rhinitis, although more structural studies about this pathology are necessary.
Montero Mora
Patricia
P
Servicio de alergia e inmunología clínica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Av. Cuauhtémoc 330, col. Doctores, CP 06720, México, DF.
Blanco
Enrique
E
Matta Campos
Juan José
JJ
González Espinosa
Alicia
A
Guidos Fogelbach
Guillermo
G
Tinajeros Castañeda
Olga Adriana
OA
D000328:Adult; D001706:Biopsy; D006801:Humans; D009297:Nasal Mucosa / Q000473:pathology*; D012221:Rhinitis, Allergic, Perennial / Q000473:pathology*