title: Synthesis of the tetracyclic core of anthracycline antibiotics by an intramolecular dehydro Diels-Alder approach.
abstract: [reaction: see text] A conceptually new approach to the tetracyclic core of the anthracycline antibiotics is reported. With use of this approach, the 7,8,9,10-tetrahydronaphthacene-5,12-dione skeleton has been synthesized in three steps, from commercially available reagents, in yields of up to 85%.
authors.affiliation: Departamento de Química Orgánica e Unidade Asociada ó CSIC, Facultade de Química, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Rodríguez
authors.forename: Luis
authors.initials: L
authors.lastname: Castedo
authors.forename: Domingo
authors.initials: D
authors.lastname: Domínguez
authors.forename: Carlos
authors.initials: C
authors.lastname: Saá
mesh_terms: D018943:Anthracyclines / Q000138:chemical synthesis*; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic