Effect of active synthetic 2-substituted quinazolinones on anti-platelet aggregation and the inhibition of superoxide anion generation by neutrophils.
Quinazolinones, 2-substituted and 3-substituted, mainly synthesized by microwave irradiation, were subjected to anti-platelet aggregation and inhibition of superoxide anion generation assays. Interestingly, 2-phenyl-4-quinazolinone (4) exhibited significant inhibitory activities toward platelet aggregation and neutrophil activation, and it might therefore serve as a prototype lead compound.
Chang
Fang-Rong
FR
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Wu
Chin-Chung
CC
Hwang
Tsong-Long
TL
Patnam
Ramesh
R
Kuo
Reen-Yen
RY
Wang
Wei-Ya
WY
Lan
Yu-Hsuan
YH
Wu
Yang-Chang
YC
D000293:Adolescent; D000328:Adult; D000818:Animals; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011799:Quinazolines / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D013481:Superoxides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013678:Technology, Pharmaceutical / Q000379:methods
D010975:Platelet Aggregation Inhibitors; D011799:Quinazolines; D013481:Superoxides