title: Chromosome aberrations in solid tumors.
abstract: Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.
authors.affiliation: Cancer Research Institute, University of California San Francisco, San Francisco, California 94143-0808, USA. albertson@cc.ucsf.edu
authors.forename: Donna G
authors.initials: DG
authors.lastname: Albertson
authors.forename: Colin
authors.initials: C
authors.lastname: Collins
authors.forename: Frank
authors.initials: F
authors.lastname: McCormick
authors.forename: Joe W
authors.initials: JW
authors.lastname: Gray
mesh_terms: D005075:Biological Evolution; D002869:Chromosome Aberrations; D018628:Gene Dosage; D006801:Humans; D008957:Models, Genetic; D009369:Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D009857:Oncogenes; D011379:Prognosis; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics
chemical_list: D020794:Receptor Protein-Tyrosine Kinases