Cyclic 3'-5' guanosine monophosphate-dependent activity in Leishmania amazonensis.
Although there are some data concerning the nitric oxide and the cyclic 3'-5'guanosine monophosphate (cGMP) signaling pathway in trypanosomatids, there is no report about the cGMP-dependent enzymatic activity identification. In this sense, a cGMP dependent activity was detected on soluble fraction from Leishmania amazonensis promastigotes with a high metacyclic level. This information is valuable in order to explore the metabolic pathway of G kinase protein in this parasite.
Géigel
L F
LF
Departamento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, Ciudad Habana, Cuba. lfgeigel@ipk.sld.cu
Leon
L L
LL
D000818:Animals; D017869:Cyclic GMP-Dependent Protein Kinases / Q000502:physiology*; D007894:Leishmania mexicana / Q000201:enzymology*; D013347:Subcellular Fractions / Q000201:enzymology
D017869:Cyclic GMP-Dependent Protein Kinases