title: Nicotinamide ribosyl uptake mutants in Haemophilus influenzae.
abstract: The gene for the nicotinamide riboside (NR) transporter (pnuC) was identified in Haemophilus influenzae. A pnuC mutant had only residual NR uptake and could survive in vitro with high concentrations of NR, but could not survive in vivo. PnuC may represent a target for the development of inhibitors for preventing H. influenzae disease.
authors.affiliation: Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom. mherbert@molbiol.ox.ac.uk
authors.forename: Mark
authors.initials: M
authors.lastname: Herbert
authors.forename: Elizabeta
authors.initials: E
authors.lastname: Sauer
authors.forename: Graeme
authors.initials: G
authors.lastname: Smethurst
authors.forename: Anita
authors.initials: A
authors.lastname: Kraiss
authors.forename: Anna-Karina
authors.initials: AK
authors.lastname: Hilpert
authors.forename: Joachim
authors.initials: J
authors.lastname: Reidl
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D001693:Biological Transport, Active; D004269:DNA, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D005816:Genetic Complementation Test; D006192:Haemophilus Infections / Q000209:etiology / Q000382:microbiology; D006193:Haemophilus influenzae / Q000235:genetics* / Q000378:metabolism*; D007700:Kinetics; D009154:Mutation; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000378:metabolism*; D011726:Pyridinium Compounds
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; C422464:NadV protein, Haemophilus ducreyi; D011726:Pyridinium Compounds; C018613:nicotinamide-beta-riboside; D009536:Niacinamide