The regulation of immunoglobulin E class-switch recombination.
Immunoglobulin E (IgE) isotype antibodies are associated with atopic disease, namely allergic rhinitis, asthma and atopic dermatitis, but are also involved in host immune defence mechanisms against parasitic infection. The commitment of a B cell to isotype class switch to an IgE-producing cell is a tightly regulated process, and our understanding of the regulation of IgE-antibody production is central to the prevention and treatment of atopic disease. Both those that are presently in use and potential future therapies to prevent IgE-mediated disease take advantage of our existing knowledge of the specific mechanisms that are required for IgE class switching.
Geha
Raif S
RS
Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA. raif.geha@tch.harvard.edu
Jabara
Haifa H
HH
Brodeur
Scott R
SR
D000818:Animals; D006801:Humans; D017578:Immunoglobulin Class Switching / Q000235:genetics / Q000276:immunology*; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D007132:Immunoglobulin Isotypes / Q000235:genetics / Q000276:immunology*; D051379:Mice
D007132:Immunoglobulin Isotypes; D007073:Immunoglobulin E