[Assessment of the protective effect of vitamin E during development of experimental myocardial damage].
It was shown that creatinphosphokinase activity of blood serum might be used as a criterion for evaluating the level of sparsely distributed damage in myocardium as a result of adrenaline administration. The protective effect of vitamin E under adrenaline-induced myocarditis was studied. The best effect was obtained after triple intramuscular injection of vitamin E before administration of pathological agent. Intravenous injection of the preparation has no benefits over that of intramuscular way of administration. Preventive action of vitamin E shows functioning itself in an increase of the quantity and activity of ubiquinone--the component of electron transport chain in mitochondria.
Donchenko
H V
HV
Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv. dongv@palladin.biochem.kiev.ua
Kuz'menko
I V
IV
Zvaĭd
R F
RF
D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D004837:Epinephrine / Q000494:pharmacology; D007273:Injections, Intramuscular; D007770:L-Lactate Dehydrogenase / Q000097:blood; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D009205:Myocarditis / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*
D014662:Vasoconstrictor Agents; D014810:Vitamin E; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D004837:Epinephrine