title: Irp9, encoded by the high-pathogenicity island of Yersinia enterocolitica, is able to convert chorismate into salicylate, the precursor of the siderophore yersiniabactin.
abstract: The Irp9 protein of Yersinia enterocolitica participates in the synthesis of salicylate, the precursor of the siderophore yersiniabactin. In Pseudomonas species, salicylate synthesis is mediated by two enzymes: isochorismate synthase and isochorismate pyruvate-lyase. Both enzymes are required for complementation of a Yersinia irp9 mutant. However, irp9 is not able to complement Escherichia coli entC for the production of enterobactin, which requires isochorismate as a precursor. These results suggest that Irp9 directly converts chorismate into salicylate.
authors.affiliation: Institut für Mikrobiologie, D-BIOL, ETHZ, 8092 Zürich, Switzerland.
authors.forename: Cosima
authors.initials: C
authors.lastname: Pelludat
authors.forename: Daniela
authors.initials: D
authors.lastname: Brem
authors.forename: Jürgen
authors.initials: J
authors.lastname: Heesemann
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002827:Chorismic Acid / Q000378:metabolism*; D053138:Cyclohexenes; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D005816:Genetic Complementation Test; D062385:Hydroxybenzoates / Q000494:pharmacology; D019751:Intramolecular Transferases / Q000235:genetics / Q000378:metabolism; D008190:Lyases / Q000235:genetics / Q000378:metabolism*; D005810:Multigene Family; D009154:Mutation; D007652:Oxo-Acid-Lyases / Q000235:genetics / Q000378:metabolism; D010636:Phenols; D011498:Protein Precursors / Q000378:metabolism; D011551:Pseudomonas fluorescens / Q000235:genetics; D012459:Salicylates / Q000378:metabolism*; D017262:Siderophores / Q000378:metabolism*; D013844:Thiazoles; D014774:Virulence / Q000235:genetics; D015008:Yersinia enterocolitica / Q000187:drug effects / Q000378:metabolism* / Q000472:pathogenicity
chemical_list: D001426:Bacterial Proteins; D053138:Cyclohexenes; D062385:Hydroxybenzoates; D010636:Phenols; D011498:Protein Precursors; D012459:Salicylates; D017262:Siderophores; D013844:Thiazoles; C104398:yersiniabactin; C015076:chrome azurol S; C052985:isochorismic acid; D008190:Lyases; C022620:salicylate synthetase; D007652:Oxo-Acid-Lyases; C075960:chorismate pyruvate lyase; D019751:Intramolecular Transferases; C058486:isochorismate synthase; D002827:Chorismic Acid