Neuroprotection in progressive brain disorders.
Progressive neurodegenerative disorders share common mechanisms of cell death, and in all likelihood multiple factors are involved in every disease. Therefore, several neuroprotective agents are being investigated with the purpose of slowing or preventing further deterioration of cell loss. These include experimental animal and clinical studies on the neuroprotective effects of caspase inhibitors, antioxidants, glutamate antagonists, anti-inflammatory agents and trophic factors in several neurodegenerative diseases. At present there is limited clinical evidence for direct neuroprotective effects against these diseases, but much effort is being invested in research on novel technologies and compounds.
Djaldetti
Ruth
R
Department of Neurology, Rabin Medical Center (Beilinson Campus), Petah Tiqva, Israel. yhaimi@bezeqint.net
Lev
Nirit
N
Melamed
Eldad
E
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D001927:Brain Diseases / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D002986:Clinical Trials as Topic; D016021:Epidemiologic Studies; D006801:Humans; D051379:Mice; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000627:therapeutic use*
D018696:Neuroprotective Agents