T102C and -1438 G/A polymorphisms of the 5-HT2A receptor gene in Turkish patients with obsessive-compulsive disorder.
OBJECTIVE
This study aimed to investigate the possible association between T102C and -1438 G/A polymorphism in the 5-HT2A receptor gene and susceptibility to and clinical features of obsessive-compulsive disorder (OCD).


METHODS
Fifty-eight patients with OCD and 83 healthy controls were included in the study. All patients were interviewed and rated by Yale-Brown Obsessive-Compulsive Scale. T102C and -1438 G/A polymorphisms of 5-HT2A receptor gene were determined by PCR technique in DNAs of peripheral leucocytes.


RESULTS
OCD patients and healthy controls did not show significant differences in genotype distribution for both polymorphisms investigated. We found that frequencies of the TT genotype for T102C polymorphism and the AA genotype for -1438 G/A polymorphism were significantly higher in patients with severe OCD compared to those with moderate or moderate-severe OCD.


CONCLUSIONS
The -1438 G/A and T102C polymorphisms of the 5-HT2A receptor gene are not associated with an increased risk of OCD. Our data suggest that the TT genotype of T102C and the AA genotype of -1438 G/A polymorphism might be a factor in clinical severity of OCD.
Tot
Senel
S
Department of Psychiatry, Mersin University Faculty of Medicine, Zeytinlibahçe cad, 33070 Mersin, Turkey. seneltot@mersin.edu.tr
Erdal
M Emin
ME
Yazici
Kemal
K
Yazici
Aylin Ertekin
AE
Metin
Ozmen
O
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000235:genetics* / Q000523:psychology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics / Q000502:physiology*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D011985:Receptors, Serotonin / Q000235:genetics*; D012016:Reference Values; D012720:Severity of Illness Index; D014421:Turkey
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin