The prognostic value of evoked responses from primary somatosensory and auditory cortex in comatose patients.
OBJECTIVE
To evaluate somatosensory and auditory primary cortices using somatosensory evoked potentials (SEPs) and middle latency auditory evoked potentials (MLAEPs) in the prognosis of return to consciousness in comatose patients.


METHODS
SEPs and MLAEPs were recorded in 131 severe comatose patients. Latencies and amplitudes were measured. Coma had been caused by transient cardiac arrest (n=49), traumatic brain injury (n=22), stroke (n=45), complications of neurosurgery (n=12) and encephalitis (n=3). One month after the onset of coma patients were classified as awake, still comatose or dead. Three months after (M3), they were classified into one of the 5 categories of the Glasgow outcome scale (GOS).


RESULTS
At M3, 41.2% were dead, 47.3% were conscious (GOS 3-5) and 11.5% had not recovered consciousness. None of the patients in whom somatosensory N20 and auditory Pa were absent did return to consciousness and in the post-anoxic group, reduced cortical amplitude too was always associated with bad outcome. Conversely, N20 and Pa were present, respectively, in 33/69 and 34/69 patients who did not recover.


CONCLUSIONS
The prognostic value of SEPs and MLAEPs in comatose patients depends on the cause of coma. Measurement of response amplitudes is informative. Abolition of cortical SEPs and/or cortical MLAEPs precludes post-anoxic comatose patients from returning to consciousness (100% specificity). In any case, the presence of short latency cortical somatosensory or auditory components is not a guarantee for return to consciousness. Late components should then be recorded.
Logi
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F
Neurologie Fonctionnelle and EA1880, Hôpital Neurologique, 59, Boulevard Pinel, 69003 Lyon, France.
Fischer
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C
Murri
L
L
Mauguière
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F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001303:Auditory Cortex / Q000502:physiology*; D003128:Coma / Q000145:classification / Q000209:etiology / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D004558:Electric Stimulation; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008875:Middle Aged; D018458:Persistent Vegetative State / Q000503:physiopathology; D020127:Recovery of Function; D013003:Somatosensory Cortex / Q000502:physiology*; D013313:Stress Disorders, Post-Traumatic / Q000150:complications / Q000503:physiopathology; D020521:Stroke / Q000150:complications / Q000503:physiopathology; D013997:Time Factors; D015898:Tomography Scanners, X-Ray Computed