[99mTc-MIBI myocardial perfusion tomography for monitoring the anthracycline cardiotoxicity].
OBJECTIVE
To investigate the value of 99mTc-MIBI myocardial perfusion tomography monitoring the cardiotoxicity induced by anthracycline.


METHODS
Twenty-three patients with anthracycline chemotherapy were examined by electrocardiogram (ECG), myocardial enzyme (CK-MB), nuclear angiography for detecting left ventricular ejection fraction (LVEF) and 99mTc-MIBI myocardial perfusion tomography for detecting myocardial relative quantity (MRQ). These examinations were repeated after every chemotherapy.


RESULTS
The MRQ after one period of anthracycline chemotherapy was significantly lower than the pretherapy in 23 patients (P < 0.01). The MRQ significantly decreased after one period of chemotherapy in 11 patients treated by pirarubicin, in 6 by epirubicin, and 6 by mitoxantrone (P < 0.05). There was not significant change in the mean value of ECG and CK-MB after one period of chemotherapy (P > 0.05). After multiple-period anthracycline chemotherapy in 10 patients, a decrease was observed in MRQ (P < 0.01). There was not significant difference in MRQ between multiple periods and one period therapy (P > 0.05) and in LVEF in the period before and after multiple-period chemotherapy (P > 0.05).


CONCLUSIONS
99mTc-MIBI myocardial perfusion tomography can monitor the anthracycline cardiotoxicity and its changes are earlier than LVEF's. 99mTC-MIBI myocardial perfusion tomography may be helpful to the clinical treatment for anthracycline.
Duan
Hua-xin
HX
Department of Nuclear Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Liang
Chang-hua
CH
Deng
Hao-yu
HY
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D013318:Stroke Volume / Q000187:drug effects*; D017256:Technetium Tc 99m Sestamibi; D014055:Tomography, Emission-Computed
D000903:Antibiotics, Antineoplastic; D017256:Technetium Tc 99m Sestamibi