Thyroid hormone action: a binding contract.
Thyroid hormones are critical for differentiation, growth, and metabolism. A new study investigating the biological role of the TH receptor TR-beta has demonstrated that DNA binding is critical for most of its functions, but also suggests that novel mechanisms independent of DNA binding may contribute to regulation of auditory function by TR-beta.
Lazar
Mitchell A
MA
University of Pennsylvania School of Medicine, 611 Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104-6149, USA. lazar@mail.med.upenn.edu
D000818:Animals; D004247:DNA / Q000378:metabolism; D006801:Humans; D008024:Ligands; D051379:Mice; D008817:Mice, Mutant Strains; D008954:Models, Biological; D011485:Protein Binding; D037042:Thyroid Hormone Receptors beta / Q000737:chemistry / Q000378:metabolism; D013963:Thyroid Hormones / Q000502:physiology*
D008024:Ligands; D037042:Thyroid Hormone Receptors beta; D013963:Thyroid Hormones; D004247:DNA