[Multivariate survival analysis for 423 patients with non-small cell lung cancer].
OBJECTIVE
Non-small cell lung cancer(NSCLC) is characterized by high incidence and poor prognosis in our country. New prognostic factors are needed to guide the treatment of patients with NSCLC. This study was designed to evaluate the characteristics and outcome in NSCLC patients who underwent completely surgical resection.


METHODS
A total of 423 cases were analyzed using SPSS10.0 software. The survival differences were compared by univariate and multivariate analysis.


RESULTS
The 5-year survival rate in this group was 46.98%. Multivariate analysis identified two poor prognostic factors: advanced TNM stage (P=0.003) and blood group B (P=0.02). Multivariate analysis also identified two better prognostic factors:adjuvant chemotherapy (P=0.04) and squamous histological type (P=0.005). The number of the risk factors (blood group B and non- squamous) were negatively related to prognosis according to multivariate analysis in stage III a NSCLC (the 5-year survival rates:43.5% vs 23.7% vs 4.0%, P< 0.001).


CONCLUSIONS
Adjuvant chemotherapy maybe is beneficial to NSCLC patients who underwent completely surgical resection. Cox multivariate analysis demonstrates that evaluation of both histological type and blood-group has a significant prognostic effect in stage IIIa patients.
Wang
Wei
W
Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, PR China. allen@gzsums.edu.cn
Rong
Tie-Hua
TH
Zhang
Li
L
Jiang
Wen-Qi
WQ
Xu
Guang-Chuan
GC
Huang
Hui-Qiang
HQ
He
You-Jian
YJ
Guan
Zhong-Zhen
ZZ
D000017:ABO Blood-Group System; D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D012044:Regression Analysis
D000017:ABO Blood-Group System