[Synthesis of some thiourea derivatives and their influence on biological and genetic effects of gamma rays].
The synthesis of the new radioprotective compounds ATB (I, 2-allylthioureidobenzoic acid), PTB (II, 2-phenylthioureidobenzoic acid), A-2-PTU (III, N-allyl-N'-2-pyridylthiourea), and P-2-PTU (IV, N-phenyl-N'-2-pyridylthiourea) and their influence on biological and genetic effects of gamma rays was studied. In result of investigations it must be noted that PTB displayed radioprotective effect as a result of which more plants in M1 germination and survive in M2 of the induced mutations is increased. The cytological analysis reveals that the studied substance (PTB) decreases chromosome aberration in meristem cells of pea roots almost twice as a result of postirradiation treatment. The effect of A-2-PTU in the experiments with peas greatly depends on the dose of irradiation, i.e., on the degree of damaging of the processes of cell restoration and the possibility of their partial restoration after the treatment with the protector. The results obtained suggest that chemical compounds of N,N'-disubstituted thiourea group (A-2-PTU and P-2-PTU) exert strong radioprotective effect in the experiments with peas. This is of great importance to modern radiobiology and radiation mutagenesis and also to protect hereditary structures against radiation.
Mehandjiev
A D
AD
Institute of Genetics, Bulgarian Academy of Sciences, Sofia, 1113 Bulgaria.
Vassilev
G N
GN
Shevchenko
V A
VA
D001671:Biochemistry / Q000379:methods; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005720:Gamma Rays; D018525:Germination / Q000187:drug effects / Q000528:radiation effects; D005875:Gibberellins / Q000378:metabolism; D009154:Mutation; D018532:Pisum sativum / Q000187:drug effects / Q000235:genetics / Q000378:metabolism / Q000528:radiation effects; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D013890:Thiourea / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D005875:Gibberellins; D011725:Pyridines; D011837:Radiation-Protective Agents; C479633:N-allyl-N'-2-pyridylthiourea; C479634:N-phenyl-N'-2-pyridylthiourea; C007842:gibberellic acid; D013890:Thiourea