title: Fatal interaction between tranylcypromine and imipramine.
abstract: This case report describes a patient on tranylcypromine who erroneously received a single dose of imipramine and subsequently developed a fatal serotonin syndrome. Both the clinical features and the pathophysiology of the serotonin syndrome are discussed.
authors.affiliation: Emergis Centre for Mental Health, Goes, The Netherlands.
authors.forename: Wim
authors.initials: W
authors.lastname: Otte
authors.forename: Tom K
authors.initials: TK
authors.lastname: Birkenhager
authors.forename: Walter W
authors.initials: WW
authors.lastname: van den Broek
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D014151:Anti-Anxiety Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy; D004347:Drug Interactions; D017809:Fatal Outcome; D006801:Humans; D007099:Imipramine / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020230:Serotonin Syndrome / Q000139:chemically induced*; D014191:Tranylcypromine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018759:Adrenergic Uptake Inhibitors; D014151:Anti-Anxiety Agents; D014191:Tranylcypromine; D007099:Imipramine