Molecular phylogeny within type I cytokines and their cognate receptors.
Type I helical cytokines are ligands for receptors structurally related by a common sequence signature. Here we analyze the 27 ligands and 34 human type I cytokine receptor encoded by the human genome. We compare these to ligands and receptors found in mouse and insects. We describe their structural relatedness to one another and discuss the evolution of these gene families.
Boulay
Jean-Louis
JL
Department of Research, University Hospital, CH-4031 Basel, Switzerland. jean-louis.boulay@unibas.ch
O'Shea
John J
JJ
Paul
William E
WE
D000818:Animals; D000852:Anopheles / Q000235:genetics / Q000276:immunology; D016207:Cytokines / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D004330:Drosophila / Q000235:genetics / Q000276:immunology; D019143:Evolution, Molecular; D006801:Humans; D051379:Mice; D005810:Multigene Family; D010802:Phylogeny; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D018121:Receptors, Cytokine / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D013045:Species Specificity; D014157:Transcription Factors / Q000378:metabolism
D016207:Cytokines; D018121:Receptors, Cytokine; D014157:Transcription Factors; D011505:Protein-Tyrosine Kinases