Fat distribution in relation to drug use, human immunodeficiency virus (HIV) status, and the use of antiretroviral therapies in Hispanic patients with HIV infection.
Human immunodeficiency virus (HIV)-associated fat-redistribution syndrome is still a subject of controversy. There is, as yet, little agreement on the definition, etiology, and prevalence of the syndrome. Many studies have examined medication or disease-related factors. Fewer studies have examined patient-related factors. Illicit drug use is an important risk factor for HIV infection, yet the role of drug use in fat distribution has not been well described. We examined fat distribution, measured by dual energy x-ray absorptiometry, in relation to drug use, smoking, and alcohol use in Hispanic patients with HIV infection and control group of HIV-negative drug users. Our results suggest that neither drug use nor alcohol consumption are predictors of fat distribution. However, among men, smoking was independently associated with less total fat, less trunk fat, and more appendicular fat. The role of patient-specific factors in the etiology of HIV-associated fat-redistribution syndrome warrants further investigation.
Forrester
J E
JE
Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, Massachusetts 02111, USA. janet.forrester@tufts.edu
Gorbach
S L
SL
D015502:Absorptiometry, Photon; D000273:Adipose Tissue; D000328:Adult; D000428:Alcohol Drinking; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D001823:Body Composition; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000208:ethnology / Q000503:physiopathology*; D039682:HIV-Associated Lipodystrophy Syndrome / Q000453:epidemiology / Q000209:etiology*; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking; D019966:Substance-Related Disorders
D019380:Anti-HIV Agents