Reevaluation of host ranges of feline leukemia virus subgroups.
We reevaluated the host ranges of feline leukemia virus (FeLV) subgroups A, B and C using pseudotype assays based on recombinant NB-tropic murine leukemia virus, which is not usually blocked after viral entry in mammalian cells. Pseudotype viruses of FeLV-B and -C infected a variety of cell lines from many mammalian species. Unexpectedly, FeLV-A pseudotype viruses of two independent isolates from the UK and US also infected a variety of non-feline cell lines including cells from humans, rabbits, pigs and minks. Moreover, both isolates of FeLV-A productively infected human embryonic kidney 293 and mink Mv-1-Lu cells. We conclude that FeLV-A is not strictly ecotropic.
Nakata
Risa
R
Research Center for Emerging Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Miyazawa
Takayuki
T
Shin
Yeon-Sil
YS
Watanabe
Rie
R
Mikami
Takeshi
T
Matsuura
Yoshiharu
Y
D000818:Animals; D002460:Cell Line / Q000821:virology; D006801:Humans; D005256:Leukemia Virus, Feline / Q000145:classification / Q000276:immunology / Q000502:physiology*; D008907:Mink; D011991:Receptors, Virus / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D013552:Swine; D014779:Virus Replication
D011991:Receptors, Virus; D011993:Recombinant Fusion Proteins