title: Lipid membranes with grafted polymers: physicochemical aspects.
abstract: Membranes grafted with water-soluble polymers resist protein adsorption and adhesion to cellular surfaces. Liposomes with surface-grafted polymers therefore find applications in drug delivery. The physicochemical properties of polymer-grafted lipid membranes are reviewed with mean-field and scaling theories from polymer physics. Topics covered are: mushroom-brush transitions, membrane expansion and elasticity, bilayer-micelle transitions, membrane-membrane interactions and protein-membrane interactions.
authors.affiliation: Max-Planck-Institut für Biophysikalische Chemie, Abteilung Spektroskopie, Am Fassberg 11, D-37077 Göttingen, Germany. dmarsh@gwdg.de
authors.forename: Derek
authors.initials: D
authors.lastname: Marsh
authors.forename: Rosa
authors.initials: R
authors.lastname: Bartucci
authors.forename: Luigi
authors.initials: L
authors.lastname: Sportelli
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism
chemical_list: D008051:Lipid Bilayers; D011108:Polymers; D011506:Proteins; D011092:Polyethylene Glycols