title: Superficial siderosis of the central nervous system many years after neurosurgical procedures.
abstract: Recurrent haemorrhage into the subarachnoid space causes superficial siderosis, which clinically manifests as cerebellar ataxia, sensorineural hearing loss, and myelopathy. Two patients developed clinical, radiological, and biochemical evidence of superficial siderosis many years after surgery. One had two posterior fossa operations, a left temporal craniectomy, and radiotherapy for a presumed brain tumour before developing clinical evidence of superficial sidersosis 37 years later. The other had small bilateral subdural collections from recurrent shunt revisions following posterior fossa surgery for a Chiari malformation, and then developed deafness and ataxia. The first patient currently has the longest recorded delay between presumed subarachnoid bleeding and clinical manifestations of superficial siderosis. Both patients provide further evidence that superficial siderosis of the central nervous system, a progressive neurodegenerative vascular condition, may be a delayed complication of neurosurgical procedures.
authors.affiliation: Department of Neurology, Royal Victoria Hospital, Belfast, UK. markmccarron@doctors.org.uk
authors.forename: M O
authors.initials: MO
authors.lastname: McCarron
authors.forename: P A
authors.initials: PA
authors.lastname: Flynn
authors.forename: C
authors.initials: C
authors.lastname: Owens
authors.forename: I
authors.initials: I
authors.lastname: Wallace
authors.forename: M
authors.initials: M
authors.lastname: Mirakhur
authors.forename: J M
authors.initials: JM
authors.lastname: Gibson
authors.forename: V H
authors.initials: VH
authors.lastname: Patterson
mesh_terms: D000328:Adult; D002493:Central Nervous System Diseases / Q000209:etiology*; D002648:Child; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D012806:Siderosis / Q000209:etiology*; D013345:Subarachnoid Hemorrhage / Q000209:etiology*; D013997:Time Factors