title: A novel 5-HT receptor ligand and related cytotoxic compounds from an acid mine waste extremophile.
abstract: Berkeley Pit Lake in Butte, Montana, is an acid mine waste reservoir rich in toxic metals. A Pithomycessp. isolated from the Pit Lake yielded three tyrosine derivatives (1-3), one of which acts as a 5-HT((2a)) receptor ligand. This type of activity has been associated with migraine preventative and antihypertensive drugs. The isolation and characterization of compounds 1-3 and three sesquiterpenes (5-7) that have been isolated previously from higher plants are reported here.
authors.affiliation: Department of Chemistry, Montana Tech of The University of Montana, Butte, Montana 59701, USA. astierle@mtech.edu
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Stierle
authors.forename: Donald B
authors.initials: DB
authors.lastname: Stierle
authors.forename: Eric
authors.initials: E
authors.lastname: Goldstein
authors.forename: Keith
authors.initials: K
authors.lastname: Parker
authors.forename: Tim
authors.initials: T
authors.lastname: Bugni
authors.forename: Chad
authors.initials: C
authors.lastname: Baarson
authors.forename: Julie
authors.initials: J
authors.lastname: Gress
authors.forename: Danielle
authors.initials: D
authors.lastname: Blake
mesh_terms: D000818:Animals; D005658:Fungi / Q000737:chemistry; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009009:Montana; D041681:NIH 3T3 Cells / Q000187:drug effects; D051381:Rats; D044402:Receptor, Serotonin, 5-HT2A / Q000187:drug effects*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014443:Tyrosine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D014866:Waste Products / Q000032:analysis*; D014867:Water / Q000032:analysis*
chemical_list: D008024:Ligands; D044402:Receptor, Serotonin, 5-HT2A; D012717:Sesquiterpenes; D014866:Waste Products; D014867:Water; D014443:Tyrosine