title: How can enzymes be so efficient?
abstract: Dudley Williams and his colleagues discuss how ligands can gain binding energy to their receptors, and substrate transition states to their enzymes, by tightening the protein structures, with a decrease in their dynamic behaviour.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: Dudley H
authors.initials: DH
authors.lastname: Williams
authors.forename: Elaine
authors.initials: E
authors.lastname: Stephens
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
mesh_terms: D001665:Binding Sites; D001667:Binding, Competitive; D004789:Enzyme Activation; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D008024:Ligands; D008956:Models, Chemical; D010100:Oxygen / Q000737:chemistry; D011485:Protein Binding / Q000235:genetics / Q000502:physiology
chemical_list: D004798:Enzymes; D008024:Ligands; D010100:Oxygen