title: Aspergillus infection after total knee arthroplasty.
abstract: The literature includes little information about the treatment protocol for Aspergillus infection after total knee arthroplasty. In this article, we describe the case of a nonimmunocompromised patient who lacked predisposing risk factors and who initially presented with aseptic loosening of a total knee prosthesis that postoperatively had grown Aspergillus niger. Intraoperative culture and frozen-section results for the pseudocapsule were negative. Two days postoperatively, culture results showed heavy growth of A niger. The patient was treated with a 6-week course of amphotericin B followed by oral antifungal therapy. She was doing well and had no symptoms 12 months after surgery.
authors.affiliation: Department of Orthopaedics, Clinical Outcome Research Center, Health Services Research and Policy School of Public Health, University of Minnesota, Minneapolis, USA.
authors.forename: Philip
authors.initials: P
authors.lastname: Langer
authors.forename: Rida A
authors.initials: RA
authors.lastname: Kassim
authors.forename: George S
authors.initials: GS
authors.lastname: Macari
authors.forename: Khaled J
authors.initials: KJ
authors.lastname: Saleh
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D001228:Aspergillosis / Q000188:drug therapy / Q000209:etiology*; D001234:Aspergillus niger; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000209:etiology*
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B