Recalcitrant oral pyoderma gangrenosum in a child responsive to cyclosporine.
We report a case of recalcitrant pyoderma gangrenosum which developed on the tongue of an 8-year-old, previously healthy boy without any systemic associated disease. The lesion was confined to the tongue and was not responsive to conventional treatment with prednisolone and sulfa drug, but it showed dramatic improvement with oral cyclosporine therapy. In addition, the histopathology of the lesion included many eosinophils, which caused difficulties in diagnosis to differentiate this condition from other oral ulcerative diseases showing tissue eosinophilia including eosinophilic ulcer of the tongue.
Park
Hyang-Joon
HJ
Department of Dermatology, College of Medicine, Dankook University, Korea.
Han
Bong-Gyun
BG
Kim
You-Chan
YC
Cinn
Yong-Woo
YW
D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D017511:Pyoderma Gangrenosum / Q000175:diagnosis / Q000188:drug therapy*
D007166:Immunosuppressive Agents; D016572:Cyclosporine