title: [Imbalance in the proteinase-inhibitor system in obstetric sepsis and septic shock].
abstract: The condition of proteinase-inhibitor balance was studied in blood plasma of patients with obstetric sepsis. Hypoproteinemia (due to a massive blood loss and toxic effect) was shown to result in a 2-5-fold decrease of the activity of endogenous proteinases in blood plasma versus the control group. The activity of alpha-macroglobulins was also by 2 times lower versus the controls, while the activity of alpha 1-antichymotrypsin and of an acid-stable inhibitor of trypsin was found to be higher by 20-30%. A degree of imbalance of proteinase/inhibitor depends on a disease severity.
authors.forename: L A
authors.initials: LA
authors.lastname: Belova
authors.forename: O G
authors.initials: OG
authors.lastname: Ogloblina
authors.forename: A A
authors.initials: AA
authors.lastname: Satalkin
authors.forename: A N
authors.initials: AN
authors.lastname: Diugeev
authors.forename: M D
authors.initials: MD
authors.lastname: Fomin
authors.forename: L G
authors.initials: LG
authors.lastname: Kashina
authors.forename: V V
authors.initials: VV
authors.lastname: Kukharchuk
mesh_terms: D010450:Endopeptidases / Q000097:blood*; D005260:Female; D006801:Humans; D007744:Obstetric Labor Complications / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011480:Protease Inhibitors / Q000378:metabolism*; D018805:Sepsis / Q000097:blood / Q000175:diagnosis*; D012772:Shock, Septic / Q000097:blood / Q000175:diagnosis; D000514:alpha 1-Antichymotrypsin / Q000097:blood; D000515:alpha 1-Antitrypsin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D011480:Protease Inhibitors; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D010450:Endopeptidases