Molecular diversity through sugar scaffolds.
Monosaccharides provide an excellent platform to tailor molecular diversity by appending desired substituents at selected positions around the sugar scaffold. The presence of five functionalized and stereo-controlled centres on the sugar scaffolds gives the chemist plenty of scope to custom design molecules to a pharmacophore model. This review focuses on the peptidomimetic developments in this area, as well as the concept of tailoring structural and functional diversity in a library using carbohydrate scaffolds and how this can lead to increased hit rates and rapid identification of leads, which has promising prospects for drug development.
Le
Giang Thanh
GT
Alchemia Pty Ltd, 3 Hi-Tech Court, Brisbane Technology Park, Eight Mile Plains QLD 4113, Australia. WMeutermans@alchemia.com.au
Abbenante
Giovanni
G
Becker
Bernd
B
Grathwohl
Matthias
M
Halliday
Judy
J
Tometzki
Gerry
G
Zuegg
Johannes
J
Meutermans
Wim
W
D000818:Animals; D002241:Carbohydrates / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism
D002241:Carbohydrates