Paraneoplastic sensory neuronopathy and spontaneous regression of small cell lung cancer.
BACKGROUND
Spontaneous tumour regression in small cell lung cancer has previously been suggested in patients with paraneoplastic neurologic syndromes. Rare documentation of this event has occurred in the literature.


METHODS
The authors report a patient with anti-Hu associated paraneoplastic sensory neuronopathy who had a spontaneous regression of her small cell lung cancer.


CONCLUSIONS
This case supports the hypothesis that anti-Hu neurologic syndromes are the consequence of a misdirected immune response to small cell tumours.
Gill
Sharlene
S
Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada.
Murray
Nevin
N
Dalmau
Josep
J
Thiessen
Brian
B
D000328:Adult; D000906:Antibodies / Q000032:analysis; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D051959:ELAV Proteins; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D009419:Nerve Tissue Proteins / Q000276:immunology; D009422:Nervous System Diseases / Q000097:blood / Q000150:complications* / Q000276:immunology; D020364:Paraneoplastic Polyneuropathy / Q000097:blood / Q000150:complications* / Q000276:immunology; D016601:RNA-Binding Proteins / Q000276:immunology; D013902:Radiography, Thoracic; D012075:Remission, Spontaneous; D012678:Sensation Disorders / Q000097:blood / Q000150:complications* / Q000276:immunology
D000906:Antibodies; D051959:ELAV Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins