title: Time course of ultraviolet B-induced erythema in people with red hair harbouring homozygous melanocortin 1 receptor mutations.
abstract: It has previously been reported that the time course of erythema may be delayed in those with sun-sensitive skin types and those with skin cancer. One molecular explanation for this putative phenotype would be that it is caused by mutations of the melanocortin 1 receptor (MC1R). In the present study of 20 persons, 10 of whom were MC1R homozygous, we measured erythema over a 21-day period in response to a range of ultraviolet B doses using methods that improved on previous studies. We could detect no consistent differences in ultraviolet radiation-induced erythema between the groups studied. The pharmacological mechanisms underpinning such prolonged inflammatory responses merit further investigation.
authors.affiliation: Systems Group, Dermatology, University of Edinburgh, Edinburgh, UK.
authors.forename: Thomas K K
authors.initials: TK
authors.lastname: Ha
authors.forename: Karen
authors.initials: K
authors.lastname: Waterston
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Bisset
authors.forename: Amanda
authors.initials: A
authors.lastname: Ray
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Rees
mesh_terms: D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D004307:Dose-Response Relationship, Radiation; D004890:Erythema / Q000209:etiology* / Q000235:genetics*; D006200:Hair Color / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D009154:Mutation; D044102:Receptor, Melanocortin, Type 1 / Q000235:genetics*; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D044102:Receptor, Melanocortin, Type 1