Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4.
Studies in both humans and rodents indicate that CD8+ T cells may be important in allergic inflammation. However, neither the mechanisms that mediate CD8+ T cell recruitment to inflamed tissues nor the relative participation of effector and central memory CD8+ T cells is known. Here we report that activated mast cells induced chemotaxis of effector, but not central memory, CD8+ T cells through production of leukotriene B4 (LTB4). These studies indicate that LTB4 production by activated peripheral leukocytes could be important for the recruitment of effector CD8+ T cells to sites of inflammation.
Ott
Vanessa L
VL
Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA. ottv@njc.org
Cambier
John C
JC
Kappler
John
J
Marrack
Philippa
P
Swanson
Bradley J
BJ
D000818:Animals; D001483:Base Sequence; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D005260:Female; D018960:Hyaluronan Receptors / Q000235:genetics / Q000276:immunology; D007975:Leukotriene B4 / Q000096:biosynthesis / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D020411:Oligonucleotide Array Sequence Analysis; D019713:Receptors, CCR5 / Q000235:genetics / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000235:genetics / Q000276:immunology; D018102:Receptors, Leukotriene B4 / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D018960:Hyaluronan Receptors; D019713:Receptors, CCR5; D015375:Receptors, Interleukin-2; D018102:Receptors, Leukotriene B4; D007975:Leukotriene B4