[2-(2'-hydroxy 2'-substituted) ethyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazines--a novel group of substances with anti-arrhythmia activity].
The antiarrhythmic activity and acute toxicity of a series of 2-(2'-hydroxy-2'-substituted) ethyl-1,2,3,4-tetrahydropyrrolo[1,2- a]pyrazines were studied. Two most promising compounds (PV-168 PV-174) are characterized by a high antiarrhythmic activity, a broad spectrum of action, and low toxicity.
Filippova
O V
OV
Pharmacology Department, Voronezh State Medical Academy, ul. Studencheskya 10, Voronezh, 394000 Russia.
Kryzhanovskiĭ
S A
SA
Peresada
V P
VP
Likhosherstov
A M
AM
Vititnova
M B
MB
Kaverina
N V
NV
Reznikov
K M
KM
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000401:mortality; D005260:Female; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D023382:Toxicity Tests, Acute
D000889:Anti-Arrhythmia Agents; D011758:Pyrroles