Chromosome aberrations in solid tumors.
Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.
Albertson
Donna G
DG
Cancer Research Institute, University of California San Francisco, San Francisco, California 94143-0808, USA. albertson@cc.ucsf.edu
Collins
Colin
C
McCormick
Frank
F
Gray
Joe W
JW
D005075:Biological Evolution; D002869:Chromosome Aberrations; D018628:Gene Dosage; D006801:Humans; D008957:Models, Genetic; D009369:Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology; D009857:Oncogenes; D011379:Prognosis; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics
D020794:Receptor Protein-Tyrosine Kinases