title: Non-invasive estimation of left ventricular end-diastolic pressure by pulmonary venous flow deceleration time.
abstract: OBJECTIVE
  The scope of this study was to assess the potential value of pulmonary venous flow diastolic deceleration time to predict end-diastolic pressure and stratify patients with regard to elevation of left ventricular end-diastolic pressures.
  
  
  RESULTS
  In 174 consecutive patients, pulmonary venous flow diastolic deceleration time was determined and compared with left ventricular end-diastolic pressures measured invasively. The sample was randomly divided into two subgroups of equal size for modelling of prediction and independent testing of the model. Predicted left ventricular end-diastolic pressures calculated from pulmonary venous flow diastolic deceleration time (left ventricular end-diastolic pressures=-10.87 + 5261/pulmonary venous flow diastolic deceleration time) agreed well with measured left ventricular end-diastolic pressures (mean difference: -1.3 +/- 3.4 mmHg). The correlation of left ventricular end-diastolic pressures with pulmonary venous flow diastolic deceleration time is fair (r=0.73989). A value of pulmonary venous flow diastolic deceleration time <220 ms is suggestive of elevated left ventricular end-diastolic pressures and should be monitored. A value of pulmonary venous flow diastolic deceleration time <190 ms predicts elevated left ventricular end-diastolic pressures. A value of pulmonary venous flow diastolic deceleration time <165 ms predicts severely elevated left ventricular end-diastolic pressures. With 190 ms as a cut-off value for elevated and 165 ms for severely elevated left ventricular end-diastolic pressures, cross-table analysis classifies all patients with normal left ventricular end-diastolic pressures correctly. No patient with severe elevation (<18 mmHg) of left ventricular end-diastolic pressures is classified as normal (chi2=102, P<0.0001).
  
  
  CONCLUSIONS
  Pulmonary venous flow diastolic deceleration time is an appropriate non-invasive measurement to stratify patients with respect to elevation of left ventricular end-diastolic pressures.
authors.affiliation: Klinik für Innere Medizin/Kardiologie Deutsches Herzzentrum Berlin, Augustenburger Platz 1, Berlin, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Olariu
authors.forename: E
authors.initials: E
authors.lastname: Wellnhofer
authors.forename: M
authors.initials: M
authors.lastname: Gräfe
authors.forename: E
authors.initials: E
authors.lastname: Fleck
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000503:physiopathology; D003654:Deceleration; D004452:Echocardiography; D005260:Female; D005858:Germany; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000503:physiopathology; D011237:Predictive Value of Tests; D011667:Pulmonary Veins / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012720:Severity of Illness Index; D013223:Statistics as Topic; D013318:Stroke Volume / Q000502:physiology*; D013997:Time Factors; D017725:Ventricular Pressure / Q000502:physiology*