Sir2 flexes its muscle.
A new report reveals a role for the mammalian NAD-dependent deacetylase Sir2 in repressing the muscle cell differentiation program and implicates the cellular redox state as a critical determinant of transcriptional activity of differentiation-specific genes.
Bedalov
Antonio
A
Clinical Research and Human Biology Divisions, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D2-100, Seattle, WA 98107, USA.
Simon
Julian A
JA
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006655:Histone Deacetylases / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000254:growth & development*; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000378:metabolism*; D056565:Sirtuin 2; D037761:Sirtuins / Q000378:metabolism*
D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D009243:NAD; C087778:SIR2 protein, S cerevisiae; D056565:Sirtuin 2; D037761:Sirtuins; D006655:Histone Deacetylases