title: Magnetoencephalographic studies of two cases of diffuse subcortical laminar heterotopia or so-called double cortex.
abstract: Two cases (a young male and a girl, suffering intractable epilepsy) of diffuse subcortical laminar heterotopia, or so-called double cortex (DC) have been investigated using magnetoencephalography (MEG). MEG confirmed involvement of both cortices (hetero- and normocortex) in the genesis of interictal spikes, and, according to the heterogeneity of DC syndrome, some differences were observed: spike initiation in the normocortex and latter involvement of the heterotopic cortex in the man, and rather a cancellation in both cortices in the girl. In addition, participation of heterotopic cortex in physiological activities could be demonstrated in the man.
authors.affiliation: Laboratoire de Physiologie-Explorations Fonctionnelles, Université de Rennes I, CHU Rennes, Rue Henri Le Guilloux, 35033 Rennes Cedex, France. pierre.toulouse@chu-rennes.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Toulouse
authors.forename: Cyril
authors.initials: C
authors.lastname: Agulhon
authors.forename: Delphine
authors.initials: D
authors.lastname: Taussig
authors.forename: Sylvia
authors.initials: S
authors.lastname: Napuri
authors.forename: Arnaud
authors.initials: A
authors.lastname: Biraben
authors.forename: Pierre
authors.initials: P
authors.lastname: Jannin
authors.forename: Michel
authors.initials: M
authors.lastname: Carsin
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Scarabin
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D002648:Child; D002828:Choristoma; D004828:Epilepsies, Partial / Q000151:congenital* / Q000503:physiopathology; D004829:Epilepsy, Generalized / Q000151:congenital* / Q000503:physiopathology; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D013036:Spasms, Infantile / Q000151:congenital* / Q000503:physiopathology