title: [Genital histoplasmosis. Presentation of a clinical case].
abstract: OBJECTIVE
  On December 1905 Darling, resident histopathologist on the Panama Channel area, observed a parasite in the large mononuclear cells of different organs. Negroni in 1914 described the first Argentinean case. Lung, oral, nasal, and laryngeal involvement are common. On the other hand, genital involvement is uncommon. The objective of this war is to communicate the case of a patient with genital histoplasmosis.
  
  
  RESULTS
  A 60-year-old Argentinian male started two years before with penile lesions and pruritus. Two partial penile resections had been performed in 1999, but pathology reports were not available. The lesions evolved towards ulceration and bleeding. Surgical toilette was carried out. A partial penectomy and glanuloplasty with an original technique were performed. Pathology revealed intracellular and extracellular spherical microorganisms. Morphologically it was histoplasma capsulatum. The histoplasmosis is an endemic mycosis. The infection takes place when inhaling the microconidiae of the fungus filamentous phase. Only a small number of people develop the disease after infection. Diagnosis is made by discovering of 2-3 micron yeasts with Giemsa stain.
  
  
  CONCLUSIONS
  If a patient from the histoplasmosis endemic area has a granular lesion, a mycotic disease should be considered.
authors.affiliation: Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires, Sección Oncología Urológica, Buenos Aires, Argentina.
authors.forename: Norberto
authors.initials: N
authors.lastname: Rodríguez
authors.forename: Marcelo
authors.initials: M
authors.lastname: Sandoval
authors.forename: Angel
authors.initials: A
authors.lastname: Alsina
authors.forename: Christian
authors.initials: C
authors.lastname: Vidal
authors.forename: Martin
authors.initials: M
authors.lastname: del Sordo
authors.forename: Federico
authors.initials: F
authors.lastname: Muro
authors.forename: Iris Nora
authors.initials: IN
authors.lastname: Tiraboschi
authors.forename: Alberto
authors.initials: A
authors.lastname: Devés
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Mazza
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001118:Argentina; D003131:Combined Modality Therapy; D006099:Granuloma / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010409:Penile Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D013194:Staining and Labeling; D013524:Surgical Flaps
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole