title: Noninvasive quantitative measurement of tissue blood flow in hepatocellular carcinoma using xenon-enhanced computed tomography.
abstract: The aim of this study was to quantitatively measure tissue blood flow (TBF) in hepatocellular carcinoma (HCC) by a noninvasive method using xenon (Xe) inhalation/CT scans and to correlate the measured TBF with histological features. TBF was measured in HCC with xenon-enhanced CT (xenon/CT) in 20 patients. In 15 patients with HCC diagnosed as hypervascular tumors by conventional CT, TBF of the tumors was significantly higher than that of noncancerous liver tissue (151.1 +/- 20 vs 42.6 +/- 20 ml/min/100 g). Histologically, these tumors were diagnosed as moderately-to-poorly differentiated HCC. In contrast, in five patients with hypovascular HCC, TBF of HCC was almost comparable to that of the noncancerous regions (45.3 +/- 6 vs 48.3 +/- 6 ml/min/100 g). All these tumors were well-differentiated HCC. In conclusions, the measured values of TBF correlate with the clinicopathologic features of liver tumors and nontumorous liver tissue in patients with HCC.
authors.affiliation: Department of Surgery and Clinical Oncology, Osaka University Medical School, Suita, Osaka, Japan.
authors.forename: Junzo
authors.initials: J
authors.lastname: Shimizu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Oka
authors.forename: Keizo
authors.initials: K
authors.lastname: Dono
authors.forename: Masato
authors.initials: M
authors.lastname: Sakon
authors.forename: Manabu
authors.initials: M
authors.lastname: Takamura
authors.forename: Takamichi
authors.initials: T
authors.lastname: Murakami
authors.forename: Shouho
authors.initials: S
authors.lastname: Hayashi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nagano
authors.forename: Shoji
authors.initials: S
authors.lastname: Nakamori
authors.forename: Koji
authors.initials: K
authors.lastname: Umeshita
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sase
authors.forename: Mitsukazu
authors.initials: M
authors.lastname: Gotoh
authors.forename: Kenichi
authors.initials: K
authors.lastname: Wakasa
authors.forename: Hironobu
authors.initials: H
authors.lastname: Nakamura
authors.forename: Morito
authors.initials: M
authors.lastname: Monden
mesh_terms: D000280:Administration, Inhalation; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D006528:Carcinoma, Hepatocellular / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging* / Q000473:pathology; D012680:Sensitivity and Specificity; D036542:Tomography, Spiral Computed