[Metabolism of heme and hemeproteins and some indices of the antioxidant system in rat erythrocytes and tissues under anemia caused by phenylhydrazine].
The decrease of activity of several antioxidant enzymes in erythrocytes in the first hours after injection of phenylhydrazine to rats (7 mg per 100 g body weight) was found to be accompanied by accumulation of heme-containing compounds in rat serum and appearance of free heme in liver and decrease of cytochrome P450 content. Tissue-specific features of dynamics of activity of enzymes studied and reduced glutathione content were revealed, that might be caused by differences in total and free heme content in these organs. The role of key enzymes of heme biosynthesis and degradation in adaptation of metabolism under phenylhydrazine action is discussed.
Kaliman
P A
PA
Karasin's National University, Kharkov.
Strel'chenko
K V
KV
Barannik
T V
TV
Nikitchenko
I V
IV
Inshina
N M
NM
Pavychenko
O V
OV
Fylymonenko
V P
VP
D000740:Anemia / Q000139:chemically induced*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D006418:Heme / Q000096:biosynthesis / Q000378:metabolism*; D006420:Hemeproteins / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D016877:Oxidants / Q000008:administration & dosage / Q000494:pharmacology*; D010659:Phenylhydrazines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D006420:Hemeproteins; D016877:Oxidants; D010659:Phenylhydrazines; C030299:phenylhydrazine; D006418:Heme; D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione