title: Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults.
abstract: We tested the hypothesis that human immunodeficiency virus (HIV)-infected adults have a specific defect in anti-pneumococcal capsular polysaccharide (Pn-specific) immunoglobulin (Ig) in fluid obtained from the lower respiratory tract. Higher levels of total IgG and IgM were present in bronchoalveolar lavage samples from HIV-infected subjects than in those from HIV-uninfected subjects. Pn-specific IgG and IgM in bronchoalveolar lavage samples were not significantly different between HIV-infected and -uninfected subjects. After pneumococcal infection, HIV-infected patients had higher bronchoalveolar lavage levels of Pn-specific IgG than HIV-infected patients without recent infection (geometric means, 387 vs. 30 ng/mL, P=.001).
authors.affiliation: Wellcome Trust Research Laboratories, College of Medicine, University of Malawi, Blantyre, Malawi. sgordon@mlw.medcol.mw
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Gordon
authors.forename: David E
authors.initials: DE
authors.lastname: Miller
authors.forename: Richard B
authors.initials: RB
authors.lastname: Day
authors.forename: Tom
authors.initials: T
authors.lastname: Ferry
authors.forename: David S
authors.initials: DS
authors.lastname: Wilkes
authors.forename: Carol T
authors.initials: CT
authors.lastname: Schnizlein-Bick
authors.forename: Eduard E
authors.initials: EE
authors.lastname: Zijlstra
authors.forename: Robert C
authors.initials: RC
authors.lastname: Read
authors.forename: Malcolm E
authors.initials: ME
authors.lastname: Molyneux
authors.forename: Homer L
authors.initials: HL
authors.lastname: Twigg
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology / Q000382:microbiology; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis* / Q000097:blood; D000918:Antibody Specificity; D016667:Bacterial Capsules / Q000276:immunology*; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood; D007075:Immunoglobulin M / Q000032:analysis / Q000097:blood; D008168:Lung / Q000276:immunology*; D008295:Malawi; D008297:Male; D011008:Pneumococcal Infections / Q000276:immunology; D012141:Respiratory Tract Infections / Q000276:immunology / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M