A novel traceless solid-phase Friedländer synthesis.
[reaction: see text] A new solid-phase synthesis of quinolines based on a Friedländer-type reaction between the resin-bound azomethine 1b and ketones 2 is described. This cyclative cleavage approach affords quinolines 3a-f in 50-81% yields. The polymer-bound aniline equivalent is easily recycled and may be reused with comparable performance.
Patteux
Claudine
C
Laboratoire de Chimie Organique Fine et Hétérocyclique UMR 6014, IRCOF-INSA, rue Tesnières B.P 08, F-76131 Mont Saint Aignan Cedex, France.
Levacher
Vincent
V
Dupas
Georges
G