Nasoethmoidal meningioma with cytogenetic features of tumor aggressiveness in a 16-year-old child.
The case of a 16-year-old girl is presented who was admitted to our hospital because of severe frontal headache. Magnetic resonance scans revealed a nasoethmoidal tumor on the right side, with erosion of the skull base and invasion of the right orbit. A needle biopsy specimen revealed the histological diagnosis of a fibroblastic meningioma (WHO grade II), with histochemically determined partial activity loss of alkaline phosphatase. The tumor was completely resected by a combined intracranial-transbasal and transnasal approach. In this case, we found a meningioma with deletion of the short arm of chromosome 1 through a translocation between chromosomes 1 and 11 [t(1;11)] as well as additional chromosomal aberrations, including partial or complete monosomy of chromosomes 2, 6, 7, 11, 13 and 22, a cytogenetic pattern known to be associated with elevated tumor aggressiveness in meningiomas of adult patients. Accordingly, this juvenile meningioma may biologically correspond to a WHO grade II adult-type meningioma with an increased risk of recurrence. Therefore, we incorporated this patient into an intensified schedule of postoperative care.
Ketter
Ralf
R
Department of Neurosurgery, Saarland University, Homburg/Saar, Germany. ncrket@med-rz.uni-sb.de
Henn
Wolfram
W
Feiden
Wolfgang
W
Prowald
Alexandra
A
Sittel
Christian
C
Steudel
Wolf-Ingo
WI
Strowitzki
Martin
M
D000293:Adolescent; D005005:Ethmoid Sinus / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D009361:Neoplasm Invasiveness / Q000235:genetics* / Q000473:pathology*; D009367:Neoplasm Staging; D009915:Orbit / Q000473:pathology / Q000601:surgery; D010255:Paranasal Sinus Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D019291:Skull Base / Q000473:pathology / Q000601:surgery