Synthesis of 4-octyl-2H-1,4-benzo-thiazin-3-ones.
Synthesis, physical and analytical properties of 6-alkylacylamino-4-octyl-2H-1,4-benzo-thiazin-3-ones derivatives are described. These new compounds were prepared by acylation and/or alkylation of the amino group under phase transfer catalysis conditions. Acid hydrolysis of the alkylacylamino-2H-1,4-benzo-thiazin-3-ones afforded N-alkylamino-benzothiazin-3-ones. Some of these compounds were evaluated in vitro for possible bacteriostatic activity.
Guarda
Vera L de M
VL
Laboratoire de chimie pharmacie, UPRESA CNRS 5077, Université Joseph-Fourier, Grenoble I, 38706, La Tronche, Cedex, France.
Perrissin
Monique
M
Thomasson
François
F
Ximenes
Eulalia A
EA
Galdino
Suely L
SL
Pitta
Ivan R
IR
Luu-Duc
Cuong
C
Barbe
Jacques
J
D000215:Acylation; D000478:Alkylation; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006868:Hydrolysis; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology
C446962:1,4-benzothiazine; D000890:Anti-Infective Agents; D013843:Thiazines