title: Lens epithelial cell migration between posterior capsule and intraocular lens with variously finished posterior optic edge and two haptic angulations.
abstract: OBJECTIVE
  To compare lens epithelial cell migration between intraocular lens (IOL) optics and the posterior capsule of IOLs with various edges and haptic angulations.
  
  
  METHODS
  Experimental acrylic IOLs with 3 types of finishing (none, polishing, tumbling and polishing) and 2 types of haptic angulation (10 and 15 degrees ) as well as 3 (AcrySof MA30BA, Sensar AR40, CeeOn 911) clinically implanted IOLs were inserted in rabbit eyes. Scanning electron-microscopic examination of IOLs was carried out before surgery and histological examination of lens capsules 3 weeks after surgery. The grading of lens epithelial cell migration under the IOL was made by scoring.
  
  
  RESULTS
  Scanning electron-microscopic examination showed that the optic edge sharpness decreased according to the finishing in experimental IOLs. The AcrySof and CeeOn lenses had sharp edges and the Sensar had a rounded edge. The migration score was highest in the IOL with a rounded edge whereas it was lowest in IOLs with a sharp edge and large haptic angulation. There was no significant difference between the scores of clinically implanted IOLs.
  
  
  CONCLUSIONS
  Sharpness of the optic edge may be a critical factor for the prevention of posterior capsule opacification and more important than haptic angulation in acrylic IOLs.
authors.affiliation: Department of Ophthalmology, Fujigaoka Hospital, Showa University School of Medicine, Yokohama, Japan. mayaki@olive.ocn.ne.jp
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ayaki
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Ishida
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nishimura
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yaguchi
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D001672:Biocompatible Materials; D019923:Capsulorhexis; D002386:Cataract / Q000473:pathology; D002465:Cell Movement; D004847:Epithelial Cells / Q000473:pathology*; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular; D007908:Lens, Crystalline / Q000473:pathology; D007910:Lenses, Intraocular; D008855:Microscopy, Electron, Scanning; D018918:Phacoemulsification; D011183:Postoperative Complications / Q000473:pathology; D011474:Prosthesis Design; D011817:Rabbits
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials