Potent and specific sialyltransferase inhibitors: imino-linked 5a'-carbadisaccharides.
Methyl 5a'-carba-beta-lactoside, imino-linked, has been shown to possess potent and specific inhibitory activity (IC50 = 185 microM) toward rat recombinant alpha2,3-sialyltransferase.
Okazaki
Kensuke
K
Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan.
Nishigaki
Sachiko
S
Ishizuka
Fumito
F
Kajihara
Yasuhiro
Y
Ogawa
Seiichiro
S
D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D008956:Models, Chemical; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D012799:Sialyltransferases / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism
D004791:Enzyme Inhibitors; D009844:Oligosaccharides; D011994:Recombinant Proteins; D012799:Sialyltransferases