title: The synthesis of an isopropyl substituted 1,4,7-triazacyclononane via an in situ sequential macrocyclisation method.
abstract: Using L-valine methyl ester hydrochloride as starting material, the synthesis of (2S)-2-isopropyl-1,4,7-trimethyl-1,4,7-triazacyclononane is described. Various standard Richman-Atkins cyclisation methods gave only poor yields in the key macrocyclisation step. Efficient macrocyclisation yields were, however, realised when an in situ sequential cyclisation method was developed.
authors.affiliation: Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, UK G1 1XL.
authors.forename: Graham
authors.initials: G
authors.lastname: Stones
authors.forename: Gilles
authors.initials: G
authors.lastname: Argouarch
authors.forename: Alan R
authors.initials: AR
authors.lastname: Kennedy
authors.forename: David C
authors.initials: DC
authors.lastname: Sherrington
authors.forename: Colin L
authors.initials: CL
authors.lastname: Gibson
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D015203:Reproducibility of Results; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; C075712:1,4,7-triazacyclononane