[Serum levels of CA-125 antigen during the first trimester of pregnancy complications and the risk of miscarriage].
BACKGROUND
The ultrasound, serum beta-HCG and progesterone titres are widely used to assess the risk of miscarriage at the early stages of pregnancy. Though very useful, they are not considered as satisfactorily accurate predictors of imminent abortion during the first three months of pregnancy.


OBJECTIVE
Prospective evaluation of clinical usefulness of serum CA125 from 4-12th week of pregnancy in a group of women with symptoms of imminent abortion.


METHODS
A study group were 250 consecutive women with symptoms of imminent abortion. Inclusion criteria were: abdominal pain, spotting, ultrasound picture of the embryo in the uterus, monovular pregnancy, normal ultrasound picture of ovaries, gestational age ranging from 4-12 weeks (assessed on a last menstrual period basis with ultrasound corroboration). 55 women with physiological course of pregnancy made up a control group. CA125 levels was evaluated with Roche Cobas Core CA125 II EIA.


RESULTS
In patients with symptoms of imminent abortion, serum CA125 titration in 4 to 12 weeks' gestation seems to be valuable only in woman with vaginal spotting or bleeding.
Fiegler
Patrycja
P
Kliniki Perinatologii i Ginekologii Slaskiej Akademii Medycznej, Katowicach.
Kamiński
Kazimierz
K
Wegrzyn
Piotr
P
D000022:Abortion, Spontaneous / Q000276:immunology; D000033:Abortion, Threatened / Q000276:immunology*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D011261:Pregnancy Trimester, First / Q000276:immunology; D011446:Prospective Studies; D014592:Uterine Hemorrhage / Q000276:immunology
D015415:Biomarkers; D018394:CA-125 Antigen