title: Malaria chemoprophylaxis in sickle cell disease.
abstract: BACKGROUND
  Malaria illness is associated with sickle cell crises. Health professionals often recommend life-long malaria chemoprophylaxis for people with sickle cell disease living in malaria endemic areas. It is therefore important we have good evidence of benefit.
  
  
  OBJECTIVE
  To assess the effects of routine malaria chemoprophylaxis in people with sickle cell disease.
  
  
  METHODS
  We searched the Cochrane Infectious Diseases Group trials register (March 2003), Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 1, 2003), MEDLINE (1966 to March 2003), EMBASE (1988 to March 2003), and LILACS (2001, 39a Edition CD-ROM), and reference lists of articles. We contacted individual researchers working in sickle cell disease research to identify any unpublished trials.
  
  
  METHODS
  Randomized and quasi-randomized controlled trials comparing chemoprophylaxis with any antimalarial drug given for a minimum of 3 months compared to placebo or no intervention.
  
  
  METHODS
  Two reviewers independently applied the inclusion criteria.
  
  
  RESULTS
  One quasi-randomized controlled trial from Uganda gave antimalarial drugs and antibiotic prophylaxis together to 126 children with homozygous sickle cell disease. The authors reported the intervention group had fewer episodes of malaria, dactylitis, and higher mean haemoglobin values.
  
  
  CONCLUSIONS
  There is very little direct evidence to support or refute giving routine chemoprophylaxis in sickle cell disease in areas where malaria is endemic.
authors.affiliation: Paediatrics Department, National Hospital, Plot 132 Central District (Phase II), PMB 425 Garki, Abuja, Nigeria.
authors.forename: O
authors.initials: O
authors.lastname: Oniyangi
authors.forename: A A A
authors.initials: AA
authors.lastname: Omari
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D008288:Malaria / Q000523:psychology*; D016032:Randomized Controlled Trials as Topic; D012805:Sickle Cell Trait / Q000150:complications*
chemical_list: D000962:Antimalarials