title: [Results of fine needle aspiration biopsy, frozen section diagnosis and definite histological results in thyroid pathology. Report of 163 cases].
abstract: BACKGROUND
  In thyroid diseases, the place of fine needle aspiration biopsy still continues to be discussed: the sensibility and specificity vary greatly in the literature. Frozen section diagnosis is necessary to form a diagnostic strategy. The objective of this study was compare the results of fine needle aspiration biopsy, frozen section diagnosis, and definitive histologic results in a population of 163 patients and to draw conclusions about treatment.
  
  
  METHODS
  From 1994 to 1999, 163 patients (132 females and, 31 males) undergoing thyroid surgery were included in this retrospective study, after a standard preoperative work-up. Those with a single palpable nodule and hypofixation on scintigraphy underwent fine needle aspiration before surgery. These results were compared with the definitive histologic results.
  
  
  RESULTS
  A loboisthmectomy was performed in 88 cases (54%), a subtotal thyroidectomy in 34 cases (21%), and a total thyrodectomy in 41 cases (25%). In the latter group, an associated neck dissection was performed in 18 cases (11%); a frozen section diagnosis was obtained in all cases of thyroid nodules. This study demonstrated a single nodule in 97 cases (60%), multiple nodules in 27 cases (17%), multinodular goitre in 34 cases (21%), and 5 Basedow diseases (3%). Sixty-two cases (38%) of thyroid nodules underwent fine needle aspiration before surgery. In 25 cases (15%), definitive pathology showed a malignant lesion. The frozen section diagnosis had a sensitivity of 73% and a specificity of 99%, and the fine needle aspiration biopsy had a sensitivity of 40% and a specificity of 100%.
  
  
  CONCLUSIONS
  The authors propose fine needle aspiration biopsy in the following cases: a single palpable nodule and hypofixation on scintigraphy or a surgical contra indication; and direct surgery in symptomatic thyroid disease or if there are one or several full nodules > 2 cm. In near future, these indications will be modified with the increasing reliability of fine needle aspiration biopsy.
authors.affiliation: Hôpital Beaujon, Service ORL et Chirurgie Cervico-Faciale, AP-HP et EMI-U 0112, Faculté Xavier Bichat, Université Paris 7, F-92110 Clichy, France.
authors.forename: P
authors.initials: P
authors.lastname: Boutin
authors.forename: A
authors.initials: A
authors.lastname: Bozorg Grayeli
authors.forename: C
authors.initials: C
authors.lastname: Terrada
authors.forename: E
authors.initials: E
authors.lastname: Rondini-Gilli
authors.forename: I
authors.initials: I
authors.lastname: Mosnier
authors.forename: N
authors.initials: N
authors.lastname: Julien
authors.forename: D
authors.initials: D
authors.lastname: Bouccara
authors.forename: O
authors.initials: O
authors.lastname: Groussard
authors.forename: B
authors.initials: B
authors.lastname: Bok
authors.forename: O
authors.initials: O
authors.lastname: Sterkers
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D005260:Female; D005629:Frozen Sections / Q000379:methods*; D006042:Goiter / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013961:Thyroid Gland / Q000473:pathology* / Q000601:surgery*; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery*; D016606:Thyroid Nodule / Q000473:pathology* / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods*