title: Ciprofloxacin-induced acute psychosis in a patient with multidrug-resistant tuberculosis.
abstract: Tuberculosis (TB) increasingly appears in a multidrug-resistant form (MDR-TB) in Europe, too. Treatment remains difficult due to various side effects of the multi-drug-regimens. Ciprofloxacin is widely used as one of the few TB-second-line drugs. We report on the course of a ciprofloxacin-induced acute psychosis in a patient with MDR(isoniazid, streptomycin)-TB which resolved after cessation of ciprofloxacin treatment and introduction of a novel oxazolidone. Careful treatment considerations particularly in patients with additional predisposing factors to neuropsychiatric symptoms are recommended in the potentially dangerous MDR-TB, thus creating an enormous therapeutic challenge.
authors.affiliation: Department of Psychiatry and Psychotherapy, University Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. cnorra@ukaachen.de
authors.forename: Christine
authors.initials: C
authors.lastname: Norra
authors.forename: Erik
authors.initials: E
authors.lastname: Skobel
authors.forename: Christian
authors.initials: C
authors.lastname: Breuer
authors.forename: Gerhard
authors.initials: G
authors.lastname: Haase
authors.forename: Peter
authors.initials: P
authors.lastname: Hanrath
authors.forename: Paul
authors.initials: P
authors.lastname: Hoff
mesh_terms: D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D002939:Ciprofloxacin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D010081:Oxazolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011605:Psychoses, Substance-Induced / Q000188:drug therapy* / Q000209:etiology* / Q000523:psychology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*
chemical_list: D000276:Adjuvants, Immunologic; D000890:Anti-Infective Agents; C461065:trifluoromethyloxazolinone; D010081:Oxazolone; D002939:Ciprofloxacin