title: Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira.
abstract: From the aerial parts of Cissampelos pareira L. (Menispermaceae), a chalcone-flavone dimer has been isolated which, mainly from NMR spectroscopic and MS data, was proved to be 2-(4-hydroxy-3-methoxyphenyl)-7-(4-methoxyphenyl)-6-(2-hydroxy-4,6-dimethoxybenzoyl)-furano[3,2-g]benzopyran-4-one. This has been assigned the trivial name cissampeloflavone. The compound has good activity against Trypanosoma cruzi and T. brucei rhodesiense and has a low toxicity to the human KB cell line.
authors.affiliation: Faculty of Pharmacy, University of Los Andes, Mérida ZP-5101, Venezuela.
authors.forename: Irama
authors.initials: I
authors.lastname: Ramírez
authors.forename: Alfredo
authors.initials: A
authors.lastname: Carabot
authors.forename: Pablo
authors.initials: P
authors.lastname: Meléndez
authors.forename: Juan
authors.initials: J
authors.lastname: Carmona
authors.forename: Manuel
authors.initials: M
authors.lastname: Jimenez
authors.forename: Asmita V
authors.initials: AV
authors.lastname: Patel
authors.forename: Trevor A
authors.initials: TA
authors.lastname: Crabb
authors.forename: Gerald
authors.initials: G
authors.lastname: Blunden
authors.forename: Peter D
authors.initials: PD
authors.lastname: Cary
authors.forename: Simon L
authors.initials: SL
authors.lastname: Croft
authors.forename: Manuel
authors.initials: M
authors.lastname: Costa
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002599:Chalcone / Q000031:analogs & derivatives* / Q000302:isolation & purification* / Q000494:pharmacology; D031606:Cissampelos / Q000737:chemistry*; D019281:Dimerization; D056890:Eukaryota / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000981:Antiprotozoal Agents; D005419:Flavonoids; D002599:Chalcone