title: Palladium-catalyzed enantiospecific reaction of propargylic carbonates with phenols: cascade chirality transfer.
abstract: [reaction: see text] A cascade chirality transfer process has been achieved by the palladium-catalyzed reaction of substituted propargylic carbonates with phenols. The reaction proceeds in a highly enantiospecific manner to produce chiral cyclic carbonates, which supports the existence of the pi-propargylpalladium intermediate in the reaction mechanism. The (E)- and (Z)-selectivity of the products can be controlled by choice of the phosphine ligand.
authors.affiliation: Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai, 980-8578, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshida
authors.forename: Mika
authors.initials: M
authors.lastname: Fujita
authors.forename: Masataka
authors.initials: M
authors.lastname: Ihara