In vivo study of microcirculation in canine myocardium using the IVIM method.
The intravoxel incoherent motion (IVIM) method was implemented in closed-chest dogs to obtain measurements on microcirculation in the left ventricular wall in vivo. Specifically, it enabled us to measure the mean microflow velocity (400 +/- 40 microm/s) and the vascular volume fraction (VVF) (11.1% +/- 2.2%), and observe the directional preference of capillary orientation. The apparent diffusion coefficients (ADCs) of water along and perpendicular to myofibers were also measured. With vasodilatation by adenosine infusion, a 25% increase in the VVF and a 7% increase in the mean microflow velocity were observed, while no change in the ADC was detected. A 28.5% decrease of the ADC was observed postmortem.
Callot
Virginie
V
Laboratory of Cardiac Energetics, NHLBI, NIH, Bethesda, Maryland 20892, USA.
Bennett
Eric
E
Decking
Ulrich K M
UK
Balaban
Robert S
RS
Wen
Han
H
D000818:Animals; D016880:Anisotropy; D001783:Blood Flow Velocity; D003287:Contrast Media / Q000008:administration & dosage; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000502:physiology*; D004285:Dogs; D019786:Gadolinium DTPA / Q000008:administration & dosage; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008833:Microcirculation / Q000502:physiology
D003287:Contrast Media; D019786:Gadolinium DTPA