title: [Acute cervical spinal epidural hematoma during antithrombotic therapy: dual warnings against antithrombotic therapy].
abstract: Two aged women suddenly suffered from severe cervical and back pain followed by ipsilateral hemiparesis sparing the face. One woman had taken anticoagulant for prosthetic mitral valve and another had taken antiplatelet for prevention of recurrent brain infarction. On admission, MRI did not document any definite lesions in the brain, and revealed epidural hematoma compressing the cervical spinal cord for both patients. We promptly stopped their anticoagulants and antiplatelets use, because the agents seemed to be the leading cause of hematoma. In addition, we performed emergent laminectomy and evacuation of hematoma for the former patient. These cases suggest dual warnings against recently prevalent antithrombotic therapy for patients with histories of thromboembolic accidents. First, we should be careful about spinal epidural hematoma as a hemorrhagic complication of antithrombotic therapy. Second, we should not misdiagnose spinal epidural hematoma as ischemic stroke nor select hyperacute thrombolytic therapy. Cervical pain and hemiparesis sparing face are important signs for distinction of spinal epidural hematoma from stroke.
authors.affiliation: Department of Cerebrovascular Disease, Cerebrovascular Center and Clinical Institute, National Kyushu Medical Center.
authors.forename: Masae
authors.initials: M
authors.lastname: Toyonaga
authors.forename: Noriko
authors.initials: N
authors.lastname: Hagiwara
authors.forename: Fumi
authors.initials: F
authors.lastname: Irie
authors.forename: Kazunori
authors.initials: K
authors.lastname: Toyoda
authors.forename: Shigeru
authors.initials: S
authors.lastname: Fujimoto
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hitotsumatsu
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okada
mesh_terms: D000208:Acute Disease; D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D020520:Brain Infarction / Q000517:prevention & control*; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D019918:Heart Valve Prosthesis Implantation; D006407:Hematoma, Epidural, Cranial / Q000139:chemically induced*; D006801:Humans; D008946:Mitral Valve Stenosis / Q000188:drug therapy / Q000601:surgery; D015912:Thrombolytic Therapy / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents