[A clinical study of hepatic arterial infusion chemotherapy with 5-FU and leucovorin for liver metastases].
We followed patients who underwent hepatic arterial infusion chemotherapy (HAI) with 5-FU and Leucovorin for liver metastases. Since CR (complete response) and PR (partial response) were achieved, this therapy seems to be effective. 5-FU metabolized on its first pass through the liver, and the hepatic extraction with rapid HAI is lower than that with slow HAI. It is suggested that control of extrahepatic lesions thought rapid HAI is useful for life prolongation.
Ichihara
Toshiaki
T
Dept. of Surgery, Ogachi Central Hospital.
Tenma
Kazuo
K
Itoh
Manabu
M
Hibino
Masanori
M
Kikuchi
Isao
I
Sasaki
Yasuhiro
Y
Hosono
Yukiko
Y
Nakamura
Masaaki
M
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D007261:Infusions, Intra-Arterial; D002955:Leucovorin / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male
D000964:Antimetabolites, Antineoplastic; D002955:Leucovorin; D005472:Fluorouracil