Depression as a risk factor for mortality after coronary artery bypass surgery.
BACKGROUND
Studies that have shown clinical depression to be a risk factor for cardiac events after coronary artery bypass graft (CABG) surgery have had small sample sizes, short follow-up, and have not had adequate power to assess mortality. We sought to assess whether depression is associated with an increased risk of mortality.


METHODS
We assessed 817 patients undergoing CABG at Duke University Medical Center between May, 1989, and May, 2001. Patients completed the Center for Epidemiological Studies-Depression (CES-D) scale before surgery, 6 months after CABG, and were followed-up for up to 12 years.


RESULTS
In 817 patients there were 122 deaths (15%) in a mean follow-up of 5.2 years. 310 patients (38%) met the criterion for depression (CES-D > or =16): 213 (26%) for mild depression (CES-D 16-26) and 97 (12%) for moderate to severe depression (CES-D > or =27). Survival analyses, controlling for age, sex, number of grafts, diabetes, smoking, left ventricular ejection fraction, and previous myocardial infarction, showed that patients with moderate to severe depression at baseline (adjusted hazard ratio [HR] 2.4, [95% CI 1.4-4.0]; p=0.001) and mild or moderate to severe depression that persisted from baseline to 6 months (adjusted HR 2.2, [1.2-4.2]; p=0.015) had higher rates of death than did those with no depression.


CONCLUSIONS
Despite advances in surgical and medical management of patients after CABG, depression is an important independent predictor of death after CABG and should be carefully monitored and treated if necessary.
Blumenthal
James A
JA
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA. blume003@mc.duke.edu
Lett
Heather S
HS
Babyak
Michael A
MA
White
William
W
Smith
Peter K
PK
Mark
Daniel B
DB
Jones
Robert
R
Mathew
Joseph P
JP
Newman
Mark F
MF
D002423:Cause of Death; D001026:Coronary Artery Bypass / Q000401:mortality* / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D016016:Proportional Hazards Models; D012307:Risk Factors; D012720:Severity of Illness Index