[Neurotransmitter mechanism of the tropoxin effect in comparison with other antimigraine preparations].
The results of experiments on cats showed that tropoxin produces no adreno- and cholinoblocking action and possesses no antihistamine properties. A comparative study of the antiserotonin cerebrovascular effect of tropoxin and some other well-known antimigraine drugs showed that tropoxin not only attenuates cerebrovascular constriction response to serotonin, but distorts these reactions so as to reduce the tone of cerebral vessels. An analogous antiserotonin activity was also observed for methysergide, dihydroergotamine, nicergoline, and (to a lower extent) tolfenamic acid, while propranolol inhibited serotonin reactions only in 50% of cases. The 5HT2 receptor blocker ketanserin significantly reduces the cerebrovascular effects of serotonin, while the 5HT3 receptor blocker tropisetron shows no such activity.
Gan'shina
T S
TS
Laboratory of Pharmacology of Cerebrovascular Disorders, Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
D000818:Animals; D001372:Aza Compounds / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects; D008881:Migraine Disorders / Q000188:drug therapy*; D011985:Receptors, Serotonin / Q000187:drug effects; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists / Q000494:pharmacology
C114333:3-(3,4,5-trimethoxybenzoyloximino)-8-methyl-8-azabicyclo(3,2,1)octane; D001372:Aza Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists