title: Neuroimaging of serotonin transporters in post-stroke pathological crying.
abstract: Pathological crying (PC) is a neuropsychiatric disorder characterized by an excessive tendency towards crying after brain damage. To elucidate the role of serotonin neurotransmission for PC, a pilot study was performed using single photon emission computed tomography with [123I]beta-CIT to estimate central (midbrain/pons and thalamus/hypothalamus) serotonin transporter (SERT) densities in 15 stroke patients who did or did not have PC. SERT binding ratios in midbrain/pons were significantly lower in the PC subgroup.
authors.affiliation: Max-Planck-Institute of Cognitive Neuroscience, Stephanstr. 1, D-04103 Leipzig, Germany.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Murai
authors.forename: Henryk
authors.initials: H
authors.lastname: Barthel
authors.forename: Jörg
authors.initials: J
authors.lastname: Berrouschot
authors.forename: Dietlind
authors.initials: D
authors.lastname: Sorger
authors.forename: D Yves
authors.initials: DY
authors.lastname: von Cramon
authors.forename: Ulrich
authors.initials: U
authors.lastname: Müller
mesh_terms: D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D002352:Carrier Proteins / Q000378:metabolism*; D003042:Cocaine / Q000031:analogs & derivatives*; D003448:Crying / Q000523:psychology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D010865:Pilot Projects; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins; D020521:Stroke / Q000378:metabolism* / Q000473:pathology*; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; C069723:2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; D003042:Cocaine