title: Identification of foals infected with Parascaris equorum apparently resistant to ivermectin.
abstract: During September 2002, routine fecal examinations performed on 16 Thoroughbred foals residing on a farm outside Toronto, Ontario, Canada, revealed low to moderate numbers of Parascaris equorum eggs in feces from 9 of the 16. All foals were then treated with ivermectin at a dose of 220 to 280 microg/kg (100 to 127 microg/lb), p.o., and fecal egg counts were repeated 12 days later. Fecal P. equorum egg counts increased between the first and second fecal examination in 7 foals, were unchanged in 1, and decreased in 5. Fecal samples were collected 13 days after treatment from 21 additional foals that had been treated with ivermectin at the same dose, and P. equorum eggs were detected in 12 of the 21. For all 37 foals, high P. equorum egg counts (> or = 100 eggs/g of feces) 12 to 13 days after ivermectin treatment were significantly more likely in foals that had been regularly treated with ivermectin since birth and permanently resided on the farm, compared with foals that had been treated with other anthelmintics or had an unknown deworming history. Collectively, these data suggested that P. equorum in these foals was resistant to ivermectin administered at the recommended dose.
authors.affiliation: Hearn Veterinary Services, 713558 RR1, Orangeville, ON L9W 2Y8, Canada.
authors.forename: F Patrick D
authors.initials: FP
authors.lastname: Hearn
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Peregrine
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000871:Anthelmintics / Q000494:pharmacology* / Q000627:therapeutic use; D017191:Ascaridida Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D001199:Ascaridoidea / Q000187:drug effects*; D004351:Drug Resistance; D005243:Feces / Q000469:parasitology; D006734:Horse Diseases / Q000188:drug therapy* / Q000469:parasitology; D006736:Horses; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary; D007559:Ivermectin / Q000494:pharmacology* / Q000627:therapeutic use; D009864:Ontario; D010270:Parasite Egg Count / Q000662:veterinary; D021261:Parasitic Sensitivity Tests / Q000662:veterinary
chemical_list: D000871:Anthelmintics; D007559:Ivermectin