Relationship between protein structures and disulfide-bonding patterns.
We found that that disulfide-bonding patterns can be used to discriminate structure similarity. Our method, based on the hierarchical clustering scheme, is applicable to proteins with two or more disulfide bonds and is able to detect the structural similarities of proteins of low sequence identities (<25%). Our results show the surprisingly close relationship between disulfide-bonding patterns and proteins structures. Our findings should be useful in protein structure modeling.
Chuang
Chao-Chun
CC
Department of Life Sciences, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsin Chu, Taiwan.
Chen
Chun-Yin
CY
Yang
Jinn-Moon
JM
Lyu
Ping-Chiang
PC
Hwang
Jenn-Kang
JK
D004220:Disulfides / Q000737:chemistry*; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry / Q000145:classification; D017386:Sequence Homology, Amino Acid
D004220:Disulfides; D011506:Proteins