New monordens produced by amidepsine-producing fungus Humicola sp. FO-2942.
Based on UV spectrum-guided purification, new monordens C, D and E, known monordens A (radicicol) and B and 5-O-methylsclerone were isolated from the fermentation broth of amidepsine-producing Humicola sp. FO-2942 by solvent extraction, silica-gel column chromatography, ODS column chromatography and HPLC. All monordens cause the cell cycle arrest at G1 and G2/M phases in Jurkat cells. But among them, monordens A and E show antifungal activity only against Aspergillus niger.
Arai
Masayoshi
M
Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.
Yamamoto
Kazunobu
K
Namatame
Ichiji
I
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D005285:Fermentation; D013329:Structure-Activity Relationship
D000935:Antifungal Agents