Morphine and antibodies to mu-opiate receptors in ultralow doses: effect on oxygen consumption.
The degree of oxygen consumption in rats was determined after intraperitoneal injection of morphine in a single dose of 5 mg/kg. Some animals were injected with morphine and perorally received morphine or antibodies to mu-opiate receptors in ultralow doses obtained by the technology of potentiation. Potentiated substances significantly reduced oxygen consumption intensified after morphinization. Potentiated morphine decreased the intensity of oxygen consumption to the level observed in intact animals. Our results indicate that morphine in ultralow doses modulates the action of this compound in toxic concentrations (bipathic phenomenon) and produces the normalizing effect. Potentiated antibodies to mu-opiate receptors modulated the effect of morphine, which indicates that they are involved in the development of opium dependence.
Pavlov
I F
IF
Institute of Molecular Biology and Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Epstein
O I
OI
D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000276:immunology*
D000906:Antibodies; D017450:Receptors, Opioid, mu; D009020:Morphine