Luminescent nonacoordinate cationic lanthanide complexes as potential cellular imaging and reactive probes.
Nonacoordinate delta- and lambda-Eu and Tb complexes have been tested as imaging and reactive probes in mouse fibroblast (NIH 3T3) cells. The uptake of these complexes by the cells was assessed by fluorescence microscopy. Complex-induced DNA damage was studied by gel electrophoresis and shown to be a function of complex chirality.
Frias
Juan C
JC
Department of Chemistry, University of Durham, South Road, Durham, UK DH1 3LE.
Bobba
Gabriella
G
Cann
Martin J
MJ
Hutchison
Chris J
CJ
Parker
David
D
D016475:3T3 Cells; D000818:Animals; D002412:Cations; D005456:Fluorescent Dyes / Q000493:pharmacokinetics; D028581:Lanthanoid Series Elements; D051379:Mice; D008856:Microscopy, Fluorescence; D009942:Organometallic Compounds / Q000493:pharmacokinetics
D002412:Cations; D005456:Fluorescent Dyes; D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds