New TRP channels in hearing and mechanosensation.
Despite extensive biophysical characterization and the superb example of the bacterial MscL channel, molecular identification of eukaryotic mechanosensitive channels has been slow. New members of the TRP superfamily have emerged as candidate channels to mediate touch, hearing, fluid flow, and osmosensation in sensory and nonsensory cells. Distinguishing between direct mechanical activation and indirect second messenger activation is still a challenge.
Corey
David P
DP
Howard Hughes Medical Institute, Boston, MA 02115, USA. dcorey@hms.harvard.edu
D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D006309:Hearing / Q000502:physiology*; D006801:Humans; D008465:Mechanoreceptors / Q000502:physiology*; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D050052:TRPC Cation Channels
D015220:Calcium Channels; D050052:TRPC Cation Channels