title: The selective functionalisation and difunctionalisation of p-substituted calix[6]arene and calix[8]arenes using hydrophilic moieties.
abstract: Methodologies to access water soluble large ringed calixarenes in good yield using efficient synthetic procedures have been investigated. Symmetrical partial functionalisations at the lower rim are described using activated [n]ethylene glycol chains and the addition behaviour contrasted with that of bromoalkanenitriles which proceeds with no observed regioselectivity. Full functionalisations of the calixarenes bearing hydrophilic groups are then investigated and a two-step procedure established which appears to be generally applicable for the addition of different [n]ethylene glycol chains. Furthermore, difunctionalisation under different reaction conditions are described. Throughout, strategies for the characterisation of these high mass compounds are outlined.
authors.affiliation: Department of Chemistry, University College London, 20 Gordon Street, London, UK WC1H 0AJ.
authors.forename: Gwénaëlle
authors.initials: G
authors.lastname: Hervé
authors.forename: Dirk Uwe
authors.initials: DU
authors.lastname: Hahn
authors.forename: Anne-Cécile
authors.initials: AC
authors.lastname: Hervé
authors.forename: Kerry J
authors.initials: KJ
authors.lastname: Goodworth
authors.forename: Alison M
authors.initials: AM
authors.lastname: Hill
authors.forename: Helen C
authors.initials: HC
authors.lastname: Hailes