Effect of Aerva lanata on solid tumor induced by DLA cells in mice.
Aerva lanata whole plant was extracted with petroleum ether, methanol and acetone. The partially TLC-purified fraction (PEF) of petroleum ether extract was proved to be cytotoxic to Dalton's lymphoma ascites (DLA), Ehrlich ascites (EA) and B16F10 cell lines in vitro. Since PEF was found to be more cytotoxic to DLA cell lines, it was used to study the pharmacological effect and its potential to reduce solid tumor induced by DLA cell lines in mice. The result indicated that PEF significantly reduced the development of solid tumor in mice.
Nevin
K G
KG
Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram 695581, India.
Vijayammal
P L
PL
D027703:Amaranthaceae; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000175:diagnosis / Q000517:prevention & control; D008223:Lymphoma / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D018514:Plant Structures; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts