Pulmonary immunoglobulin responses to Streptococcus pneumoniae are altered but not reduced in human immunodeficiency virus-infected Malawian adults.
We tested the hypothesis that human immunodeficiency virus (HIV)-infected adults have a specific defect in anti-pneumococcal capsular polysaccharide (Pn-specific) immunoglobulin (Ig) in fluid obtained from the lower respiratory tract. Higher levels of total IgG and IgM were present in bronchoalveolar lavage samples from HIV-infected subjects than in those from HIV-uninfected subjects. Pn-specific IgG and IgM in bronchoalveolar lavage samples were not significantly different between HIV-infected and -uninfected subjects. After pneumococcal infection, HIV-infected patients had higher bronchoalveolar lavage levels of Pn-specific IgG than HIV-infected patients without recent infection (geometric means, 387 vs. 30 ng/mL, P=.001).
Gordon
Stephen B
SB
Wellcome Trust Research Laboratories, College of Medicine, University of Malawi, Blantyre, Malawi. sgordon@mlw.medcol.mw
Miller
David E
DE
Day
Richard B
RB
Ferry
Tom
T
Wilkes
David S
DS
Schnizlein-Bick
Carol T
CT
Zijlstra
Eduard E
EE
Read
Robert C
RC
Molyneux
Malcolm E
ME
Twigg
Homer L
HL
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology / Q000382:microbiology; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis* / Q000097:blood; D000918:Antibody Specificity; D016667:Bacterial Capsules / Q000276:immunology*; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood; D007075:Immunoglobulin M / Q000032:analysis / Q000097:blood; D008168:Lung / Q000276:immunology*; D008295:Malawi; D008297:Male; D011008:Pneumococcal Infections / Q000276:immunology; D012141:Respiratory Tract Infections / Q000276:immunology / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000276:immunology*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M