Photosensitized DNA cleavage promoted by amino acids.
A novel class of DNA cleavage agents are reported that derive activity from amino acids tethered to a photoactive intercalator.
Mahon
Kerry P
KP
Boston College, Eugene F. Merkert Chemistry Center, Chestnut Hill, MA 02467, USA.
Ortiz-Meoz
Rodrigo F
RF
Prestwich
Erin G
EG
Kelley
Shana O
SO
D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles; D004247:DNA / Q000737:chemistry / Q000187:drug effects* / Q000528:radiation effects; D004587:Electrophoresis, Agar Gel; D004926:Escherichia coli / Q000235:genetics; D005456:Fluorescent Dyes / Q000737:chemistry; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D010957:Plasmids / Q000737:chemistry / Q000187:drug effects / Q000528:radiation effects; D011804:Quinolines; D013844:Thiazoles / Q000737:chemistry; D013997:Time Factors
D000596:Amino Acids; D052160:Benzothiazoles; D005456:Fluorescent Dyes; D017319:Photosensitizing Agents; D011804:Quinolines; D013844:Thiazoles; C051000:thiazole orange; D004247:DNA