Microdialysis in pain research.
In vivo microdialysis has been used in preclinical pain research for more than a decade. This valuable tool allows correlations between nociceptive behavior and neurotransmitter release in pain-related CNS sites. However, several methodological issues must be considered to adequately interpret microdialysis data. Thus, the aim of this review is to describe key considerations, potential pitfalls, and important control experiments. We focus on animal experiments which evaluate the effects of noxious stimulation on CNS neurotransmitter release, particularly those that address clinically relevant problems in patients with long-lasting painful conditions.
Stiller
Carl-Olav
CO
Division of Clinical Pharmacology, Department of Medicine, Karolinska Hospital, SE-17177, Stockholm, Sweden.
Taylor
Bradley K
BK
Linderoth
Bengt
B
Gustafsson
Henrik
H
Warsame Afrah
Abdullahi
A
Brodin
Ernst
E
D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001921:Brain; D006801:Humans; D017551:Microdialysis; D018377:Neurotransmitter Agents / Q000378:metabolism; D010146:Pain / Q000188:drug therapy*; D013116:Spinal Cord
D000700:Analgesics; D018377:Neurotransmitter Agents