[Evaluation of cerebral circulatory compensation after carotid artery occlusion in rabbits].
OBJECTIVE
To observe the cerebral circular changes of rabbits during brain ischemia caused by carotid artery occlusion (CAO) with a loading test-cerebral vascular CO2 reactivity (CVR) technique.


METHODS
Sixty white rabbits were divided into 6 groups, before and during 0-50 days after CAO, we studied the regional cerebral blood flow (rCBF) and CVR of frontal lobe on the same side, using laser doppler perfusion imager (LDI).


RESULTS
The rCBF-lesion caused by CAO could hardly be observed (P > 0.5), but CVR cut down obviously (P < 0.01).


CONCLUSIONS
The loading test-cerebral vascular CO2 reactivity (CVR) allow the hemodynamic effect of a CAO on the intracerebral circulation to be observed before the reduced rCBF can be detected.
Zhou
T
T
Department of Neurosurgery, PLA General Hospital, Beijing 100853, China. zhoutaolayn@fm365.com
Zhang
Y Z
YZ
D000818:Animals; D001921:Brain / Q000098:blood supply; D002245:Carbon Dioxide; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D011817:Rabbits; D012039:Regional Blood Flow; D017585:Ultrasonography, Doppler, Transcranial
D002245:Carbon Dioxide