Pleuropulmonary blastoma in a young adult presenting as a ruptured cystic teratoma in radiology.
Pleuropulmonary blastoma (PPB) is a rare malignant dysontogenetic neoplasm primarily affecting children and is characterized histologically by a variably mixed blastematous and sarcomatous patterns. We herein report a very exceptional adult case of PPB. A 21-yr-old male patient presented with a left chest pain of two weeks' duration. A computed tomography scan revealed a large, multicystic tumor occupying the left lower hemithorax, leading to the impression of a ruptured mediastinal cystic teratoma. A thoracotomy for resection of the tumor was performed. On histologic examination, the tumor consisted of cystic walls and associated solid lesions which showed undifferentiated blastemal tissues with focal fibrosarcomatous and rhabdoid features. Immunohistochemically the tumor cells only showed diffuse strong positivity for vimentin. The histologic findings corresponded to a type II PPB. The authors suggest that PPB, especially of type I or II, should be included in the radiologic differential diagnosis of mediastinal cystic neoplasms in a young adult.
Lee
Chang Hun
CH
Department of Pathology, Pusan National University College of Medicine, Busan, Korea. cnlee@pusan.ac.kr
Kim
Keun Il
KI
Kim
Young Dae
YD
Lee
Min Ki
MK
Kim
Jee Yeon
JY
Park
Do Youn
DY
Sol
Mee Young
MY
Suh
Kang Suek
KS
D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D008297:Male; D018202:Pulmonary Blastoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D013724:Teratoma / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000096:biosynthesis
D014746:Vimentin