title: A new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase.
abstract: Two analogues of porphobilinogen, the 6-methyl and 6,11-ethano derivatives, have been made by a new synthetic route and the 6-methyl analogue has proved to be the most potent inhibitor of hydroxymethylbilane synthase yet reported (Ki = 3 microM).
authors.affiliation: University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: Raef
authors.initials: R
authors.lastname: Ahmed
authors.forename: Finian J
authors.initials: FJ
authors.lastname: Leeper
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D011163:Hydroxymethylbilane Synthase / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008956:Models, Chemical; D011162:Porphobilinogen / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: D004791:Enzyme Inhibitors; D011162:Porphobilinogen; D011163:Hydroxymethylbilane Synthase