title: [Early diagnosis of Kawasaki disease complicated by coronary artery lesions].
abstract: OBJECTIVE
  To explore the possibility of early diagnosis of Kawasaki disease (KD) complicated by coronary artery lesions (CAL).
  
  
  METHODS
  Medical records of 84 children with KD (2 months to 8 years of age) were reviewed retrospectively. Diagnosis of KD was based on current diagnostic criteria of KD. Laboratory examinations were performed for white blood cells (WBC), hemoglobin (HB), platelet counts (Plt), and C-reactive protein (CRP), along with electrocardiography (ECG) and echocardiography within 7 days after the onset of the disease. The Pearson correlation and multivariate analysis (logistic) were used for statistical analysis.
  
  
  RESULTS
  During the first 7 days, clinical manifestations of the patients included fever (100%), conjunctivitis (71.46%), skin rash (66.7%), extremity change (54%), oral mucosa change (80%), and cervical lymphadenopathy (25%). Laboratory examinations revealed elevated WBC, CRP, and ECG (P<0.05, 0.05,0.01, respectively) in patients with CAL. Multivariate logistic regression analysis indicated that ECG positivity (P<0.01) and WBC increases (P<0.01) were independently correlated with CALs in acute KD.
  
  
  CONCLUSIONS
  CRP (+), ECG (+), WBC count increase during the acute phase of KD are important indicators to predict CAL caused by KD.
authors.affiliation: Department of Pediatrics, General Hospital of the Navy, Beijing 100037, China.
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Hu
authors.forename: Shi-xia
authors.initials: SX
authors.lastname: Xu
authors.forename: Zuo
authors.initials: Z
authors.lastname: Luan
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003327:Coronary Disease / Q000175:diagnosis*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D016015:Logistic Models; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D010976:Platelet Count; D012189:Retrospective Studies
chemical_list: D006454:Hemoglobins; D002097:C-Reactive Protein