Ultralow doses of antibodies to inflammatory mediators: antitussive properties of antibodies to bradykinin, histamine, and serotonin.
We studied antitussive activity of antibodies to inflammatory mediators (bradykinin, histamine, and serotonin) in ultralow doses. Experiments were performed on guinea pigs with cough induced by citric acid and capsaicin. Test preparations suppressed cough produced by citric acid. Antibodies to bradykinin in ultralow doses were most potent in relieving capsaicin-induced cough (up to 85%); antibodies to serotonin and, particularly, to histamine produced a smaller effect. Potentiated histamine and serotonin possessed polymodal properties.
Epstein
O I
OI
Materia Medica Holding Research-and-Production Company, Moscow.
Kovaleva
V L
VL
Zak
M S
MS
Dugina
Yu L
YL
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000996:Antitussive Agents / Q000494:pharmacology*; D001920:Bradykinin / Q000276:immunology*; D002211:Capsaicin / Q000009:adverse effects; D019343:Citric Acid / Q000009:adverse effects; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine / Q000276:immunology*; D006801:Humans; D008297:Male; D012701:Serotonin / Q000276:immunology*
D000906:Antibodies; D000996:Antitussive Agents; D019343:Citric Acid; D012701:Serotonin; D006632:Histamine; D002211:Capsaicin; D001920:Bradykinin