Cutaneous and lingual papules as a sign of beta 2 microglobulin-derived amyloidosis in a long-term hemodialysis patient.
Although hemodialysis has permitted long-term survival of patients with renal failure, beta 2 microglobulin-derived amyloidosis is a serious complication occurring most commonly in long-term hemodialysis patients. Orthopedic manifestations are quite common, but cutaneous and lingual manifestations are relatively uncommon. We report a 56-year-old patient with lichenoid plaque type of skin eruptions and lingual papules caused by beta 2 microglobulin-derived amyloidosis. Immunohistochemical study showed that amyloid deposits were positive for anti-beta 2 microglobulin antibody, but negative for anti-advanced glycation end products antibody (anti-CML and CLE antibody). We discuss the histological and the clinical features of skin manifestations of beta 2 microglobulin-derived amyloidosis.
Uenotsuchi
Takeshi
T
Department of Dermatology, Hiroshima Red Cross Hospital, Hiroshima, Japan. uenotti@dermatol.med.kyushu-u.ac.jp
Imafuku
Shinichi
S
Nagata
Masaharu
M
Kiryu
Hiromaro
H
Morita
Keisuke
K
Koga
Tetsuya
T
Furue
Masutaka
M
D000686:Amyloidosis / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D017512:Lichenoid Eruptions / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D014059:Tongue / Q000473:pathology; D001613:beta 2-Microglobulin / Q000378:metabolism*
D017127:Glycation End Products, Advanced; D001613:beta 2-Microglobulin