[Molecular biology: generality].
The molecular analysis of chromosomal abnormalities associated with hematologic malignancies allowed the identification of genes involved in these rearrangements as well as of some recurrent mechanisms--gene deregulation, gene fusion--leading to the development of a tumoral process. PCR tools are now available, in addition to conventional and molecular cytogenetics, to detect and quantify these rearrangements, allowing a better follow-up for the patients.
Bastard
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Laboratoire de génétique oncologique, centre Henri-Becquerel, rue d'Amiens, 76038 Rouen, France. christian.bastard@rouen.fnclcc.fr
D002869:Chromosome Aberrations; D003582:Cytogenetics; D019337:Hematologic Neoplasms / Q000235:genetics*; D006801:Humans; D008967:Molecular Biology / Q000379:methods; D016133:Polymerase Chain Reaction