[Chromosomal translocations in human malignant hematopoiesis. Structural and functional consequences].
The improvement of molecular biology techniques and human genome mapping and sequencing boosted the molecular analysis of chromosomal abnormalities observed in human hematological malignancies. The characterization of structural abnormalities (translocation, deletion) has proven particularly seminal. A better understanding of the pathology itself and of its generation arose from the identification of the genes involved in the chromosomal translocations of human leukemia. This work summaries some of the present knowledge regarding human leukemogenesis.
Nguyen Khac
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E210 Inserm, Tour Pasteur, hôpital Necker-Enfants-malades, 149, rue de Sèvres, 75743 Paris 15, France.
Bernard
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D050657:Core Binding Factor alpha Subunits; D004268:DNA-Binding Proteins / Q000235:genetics; D019337:Hematologic Neoplasms / Q000235:genetics*; D006410:Hematopoiesis; D006801:Humans; D007938:Leukemia / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000235:genetics; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000235:genetics; D015533:Transcriptional Activation; D014178:Translocation, Genetic
D050657:Core Binding Factor alpha Subunits; D004268:DNA-Binding Proteins; D011993:Recombinant Fusion Proteins; D050656:Transcription Factor AP-2; D014157:Transcription Factors; C406688:core binding factor alpha