title: [Pathological features of prostate cancer in Chinese cohort detected through mass screening and their relationships with serum prostate specific antigen].
abstract: OBJECTIVE
  To investigate the pathological features of the prostate biopsy through mass screening for prostate cancer in Chinese cohort and their relationships with serum prostate specific antigen (PSA).
  
  
  METHODS
  ELISA was used to measured the serum PSA in 12 027 Chinese men aged 50 and over in Changchun, Jilin Province. Transrectal ultrasound guided six-sextant biopsy was performed on 137 cases with the serum PSA value > 4.0 micro g/L and 21 cases with the serum PSA < 4.0 micro g/L but with urethral obstructive symptoms. Pathological analysis was done with the aid of statistic software SPSS 10.0.
  
  
  RESULTS
  Of the 158 biopsies, 41 cases of prostatic carcinoma were found (25.9%, 41/158). The moderately differentiated carcinoma and poorly differentiated carcinoma accounted for 61% and 34% respectively. In these 41 cases of prostate cancer, a significant linear positive correlation between the serum PSA and the Gleason score (r = 0.329, P < 0.05) and a significant linear positive correlation between the serum PSA and the positive counts of carcinoma in six-sextant biopsy (r = 0.425, P = 0.006) were found.
  
  
  CONCLUSIONS
  The moderately differentiated carcinoma is the most common type of prostate cancer. The approach of mass screening opens a new avenue for the early detection of prostate cancer. Serum PSA value is not only associated with the pathological grading but also with the extension of tumor.
authors.affiliation: Department of Pathology, The Second Clinical Hospital, Jilin University, Changchun 130041, China.
authors.forename: Hong-wen
authors.initials: HW
authors.lastname: Gao
authors.forename: Yu-lin
authors.initials: YL
authors.lastname: Li
authors.forename: Shan
authors.initials: S
authors.lastname: Wu
authors.forename: Yi-shu
authors.initials: YS
authors.lastname: Wang
authors.forename: Yu-zhuo
authors.initials: YZ
authors.lastname: Pan
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Xue-jian
authors.initials: XJ
authors.lastname: Zhao
mesh_terms: D001707:Biopsy, Needle; D015331:Cohort Studies; D006801:Humans; D008297:Male; D008403:Mass Screening; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology*
chemical_list: D017430:Prostate-Specific Antigen