title: Light emitting diode irradiation protect against the amyloid beta 25-35 induced apoptosis of PC12 cell in vitro.
abstract: OBJECTIVE
  Whether light emitting diode (LED) irradiation has effects on "beta-amyloid (A beta) induced apoptosis," a leading hypothesis of the cause of Alzheimer's disease (AD), or not?
  
  
  METHODS
  Monolayer cell cultures of PC12 were subjected to A beta or/and LED irradiation at various intensity. Cell apoptosis was confirmed by morphological criteria, DNA fragmentation assay, and FAScan flow cytometer assay.
  
  
  RESULTS
  Treatment of the cells with LED irradiation significantly diminished A beta induced apoptosis within 24 hours.
  
  
  CONCLUSIONS
  The LED irradiation, when utilized at power of 0.9 W/m(2) and 60 minutes has significantly diminished A beta induced apoptosis of PC12 cells.
authors.affiliation: Laboratory of Laser Sports Medicine, College of Sports Science, South China Normal University, Guangzhou, 510631, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Duan
authors.forename: Ling
authors.initials: L
authors.lastname: Zhu
authors.forename: Timon Cheng-Yi
authors.initials: TC
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
authors.forename: Jianling
authors.initials: J
authors.lastname: Jiao
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Xu
authors.forename: Libo
authors.initials: L
authors.lastname: Yao
authors.forename: Songhao
authors.initials: S
authors.lastname: Liu
mesh_terms: D016229:Amyloid beta-Peptides / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D008027:Light; D016716:PC12 Cells; D010446:Peptide Fragments / Q000502:physiology*; D051381:Rats; D013997:Time Factors
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35)