[FTIR studies of chlorobenly-5-fluorouracil porphyrin].
In this paper new kind of porphyrin compounds was prepared, which combined well the affinity of prophyrin to malignant tumour with anticancer of 5-fluorouracil porphyrin. The IR spectra of m- and p-chlorophenyl-5-fluorouracil prophyrin were obtained and analyzed. The IR absorption peaks were investigated and concluded in detail. The IR absorption rule of chloropenly-5-fluorouracil prophyrin which occurred when m-substitution and p-substitution appeared respectively on phenyl, and single substitution of N1 and double substitution of N1 appeared respectively on phenyl or N1 and N1, N3 positions on pyrimidine ring was also discussed. The results show that the relative intensity of nu c-o stretching vibration changed obviously by field-effect when the substitution was strong electro-negative group. Meanwhile, the IR spectral characteristics of the compounds mentioned above were revealed, and this can be used to deduce the stereochemistry structure of them.
He
Shu-mei
SM
Experiment Center, Department of Chemistry, Hebei Normal University, Shijiazhuang 050016, China.
Liu
Yan-qin
YQ
Qiu
Hong
H
Cui
Wen-yan
WY
D000964:Antimetabolites, Antineoplastic / Q000737:chemistry*; D005472:Fluorouracil / Q000031:analogs & derivatives / Q000737:chemistry*; D015394:Molecular Structure; D011166:Porphyrins / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
D000964:Antimetabolites, Antineoplastic; D011166:Porphyrins; C487675:chlorobenly-5-fluorouracil porphyrin; D005472:Fluorouracil