title: Structure and biological activity of cationic [PtLCl(DMSO)]NO(3).DMSO complex containing a chelated diaminosugar: methyl-3,4-diamino-2,3,4,6-tetradeoxy-alpha-L-lyxopyranoside.
abstract: Cationic platinum(II) complex [Pt(C(7)H(16)N(2)O(2))(DMSO)Cl]NO(3).DMSO containing one chloride anion, methyl-3,4-diamino-2,3,4,6-tetradeoxy-alpha-L-lyxopyranoside (C(7)H(16)N(2)O(2)) and dimethylsulfoxide (DMSO) molecules forming a square-plane has been prepared and characterised, both spectroscopically and by single-crystal X-ray diffraction. Biological tests performed using leukemia L1210 cells have shown that toxicity of the title complex is similar to that of cisplatin.
authors.affiliation: Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195, Warsaw, Poland. lfuks@ichtj.waw.pl
authors.forename: Leon
authors.initials: L
authors.lastname: Fuks
authors.forename: Krystyna
authors.initials: K
authors.lastname: Samochocka
authors.forename: Romana
authors.initials: R
authors.lastname: Anulewicz-Ostrowska
authors.forename: Marcin
authors.initials: M
authors.lastname: Kruszewski
authors.forename: Waldemar
authors.initials: W
authors.lastname: Priebe
authors.forename: Wlodzimierz
authors.initials: W
authors.lastname: Lewandowski
mesh_terms: D000606:Amino Sugars / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D002470:Cell Survival; D002945:Cisplatin / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D007939:Leukemia L1210; D051379:Mice; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000606:Amino Sugars; D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D002945:Cisplatin; D004121:Dimethyl Sulfoxide