Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.
We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis.
Matsumoto
Kenji
K
Gifu International Institute of Biotechnology, 1-1 Naka-Fudogaoka, Kakamigahara, Gifu 504-0838, Japan. kmatsumoto@giib.or.jp
Akao
Yukihiro
Y
Kobayashi
Emi
E
Ohguchi
Kenji
K
Ito
Tetsuro
T
Tanaka
Toshiyuki
T
Iinuma
Munekazu
M
Nozawa
Yoshinori
Y
D017209:Apoptosis / Q000187:drug effects*; D015153:Blotting, Western; D029760:Garcinia / Q000737:chemistry*; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D007214:Indonesia; D020128:Inhibitory Concentration 50; D007938:Leukemia; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D044004:Xanthones; C021053:mangostin