Transplantation of neural stem cells into the spinal cord after injury.
Thanks to advances in the stem cell biology of the central nervous system (CNS), the previously inconceivable regeneration of the damaged CNS is approaching reality. The availability of signals to induce the appropriate differentiation of the transplanted and/or endogenous neural stem cells (NSCs) as well as the timing of the transplantation are important for successful functional recovery of the damaged CNS. Because the immediately post-traumatic microenvironment of the spinal cord is in an acute inflammatory stage, it is not favorable for the survival and differentiation of NSC transplants. On the other hand, in the chronic stage after injury, glial scars form in the injured site that inhibit the regeneration of neuronal axons. Thus, we believe that the optimal timing of transplantation is 1-2 weeks after injury.
Okano
Hideyuki
H
Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan. hidokano@sc.itc.keio.ac.jp
Ogawa
Yuto
Y
Nakamura
Masaya
M
Kaneko
Shinjiro
S
Iwanami
Akio
A
Toyama
Yoshiaki
Y
D000818:Animals; D009416:Nerve Regeneration / Q000502:physiology; D009474:Neurons / Q000166:cytology*; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000628:therapy*; D033581:Stem Cell Transplantation