Peptide based adsorbers for therapeutic immunoadsorption.
Peptides as ligands for immunoadsorption exhibit several potential advantages over native proteins. Two newly developed adsorbers are based on peptides covalently coupled to sepharose CL-4B. Globaffin is capable of binding immunoglobulins independent from their antigen specificity and thus, applicable in transplant recipients and several antibody mediated autoimmune diseases. Among others, the most important disorders suitable for the treatment with Globaffin are rheumatoid arthritis, systemic lupus erythematosus, and acute renal transplant rejection. Coraffin is a specific adsorber using two linear peptide ligands mimicking epitopes of the beta1-adrenergic receptor, that bind corresponding autoantibodies from patients suffering from idiopathic dilated cardiomyopathy. Specific immunoadsorption has been shown to be beneficial for patients with dilated cardiomyopathy. Coraffin can be used as a new therapeutic option for these patients, who get only limited benefit from medical therapy. Both adsorbers may be combined with all approved apheresis control devices available.
Rönspeck
Wolfgang
W
Affina-Immuntechnik GmbH, Berlin, Germany.
Brinckmann
Roland
R
Egner
Ralf
R
Gebauer
Frank
F
Winkler
Dirk
D
Jekow
Petra
P
Wallukat
Gerd
G
Müller
Johannes
J
Kunze
Rudolf
R
D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000628:therapy; D001781:Blood Component Removal / Q000295:instrumentation / Q000379:methods; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use*; D007163:Immunosorbent Techniques / Q000295:instrumentation*; D007164:Immunosorbents / Q000737:chemistry / Q000627:therapeutic use*; D010455:Peptides / Q000737:chemistry / Q000627:therapeutic use*; D012680:Sensitivity and Specificity
D001323:Autoantibodies; D007136:Immunoglobulins; D007164:Immunosorbents; D010455:Peptides