[Pharmacological activity of mexidol in the stress-induced liver damage].
Pretreatment with mexidol (100 mg/kg) offered protection under the conditions of acute (3 h) liver damage in rats under the conditions of immobilization stress. The drug inhibited lipid peroxidation, enhanced intrinsic antioxidant protection function, and normalized the activity of enzymes-markers of hepatocyte damage. In addition, the treatment with mexidol normalized the level of bilirubin in the blood serum and stimulated the detoxicating function of liver in the bromsulphalein test.
Deviatkina
T A
TA
Experimental and Clinical Pharmacology Department, Medical Stomatology Academy, ul. Shevchenko 23, 36024 Poltava, Ukraine.
Lutsenko
R V
RV
Vazhnichaia
E M
EM
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D001663:Bilirubin / Q000097:blood; D007103:Immobilization; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D010847:Picolines / Q000494:pharmacology*; D051381:Rats; D013315:Stress, Psychological / Q000097:blood / Q000378:metabolism*
D000975:Antioxidants; D010847:Picolines; C070020:emoxypine succinate; D001663:Bilirubin