Increased use of antibiotics in clozapine-treated patients.
A retrospective chart review of hospitalized patients was completed to verify whether there were differences in the prescription rate of antibiotics to patients treated with clozapine. Subjects were inpatients with a diagnosis of schizophrenia or schizoaffective disorder. Charts of all patients who received clozapine for 24 consecutive months during a period of 48 consecutive months of hospitalization were selected for the study. For each patient, we compared the number of infections treated with an antibiotic during the 24 months pre-clozapine versus the period when they were treated with clozapine. Our study suggests that the number of antibiotic prescriptions is significantly increased in patients treated with clozapine.
Landry
Pierre
P
Hôpital Louis-H. Lafontaine, Module de Psychopharmacologie, University of Montreal, 74012 Hochelaga, Montreal, Quebec H1N 3M5, Canada. plandry@ssss.gouv.qc.ca
Benaliouad
Faïza
F
Tessier
Sylvie
S
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008499:Medical Records / Q000706:statistics & numerical data; D008875:Middle Aged; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D012189:Retrospective Studies
D000900:Anti-Bacterial Agents; D014150:Antipsychotic Agents; D003024:Clozapine