Polymer-directed enzyme prodrug therapy.
Over the last 20 years many attempts have been made to develop a drug targeting or delivery system that could avoid the problems of organ toxicity and drug resistance. Polymer-directed enzyme prodrug therapy is an attempt to produce a targeting and delivery system that will improve the therapeutic index. Components of the system are polymers--used as the drug carrier, drugs and linkers. A number of polymer-directed enzyme prodrug therapies have been tested in the clinic; results obtained in a phase I trial with PK1 are described.
Cassidy
J
J
Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen, UK.