Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies.
We describe extensions to the method of Pritchard et al. for inferring population structure from multilocus genotype data. Most importantly, we develop methods that allow for linkage between loci. The new model accounts for the correlations between linked loci that arise in admixed populations ("admixture linkage disequilibium"). This modification has several advantages, allowing (1) detection of admixture events farther back into the past, (2) inference of the population of origin of chromosomal regions, and (3) more accurate estimates of statistical uncertainty when linked loci are used. It is also of potential use for admixture mapping. In addition, we describe a new prior model for the allele frequencies within each population, which allows identification of subtle population subdivisions that were not detectable using the existing method. We present results applying the new methods to study admixture in African-Americans, recombination in Helicobacter pylori, and drift in populations of Drosophila melanogaster. The methods are implemented in a program, structure, version 2.0, which is available at http://pritch.bsd.uchicago.edu.
Falush
Daniel
D
Department of Molecular Biology, Max-Planck Institut für Infektionsbiologie, Schumann Strasse 21/22, 10117 Berlin, Germany. falush@mpiib-berlin.mpg.de
Stephens
Matthew
M
Pritchard
Jonathan K
JK
D000465:Algorithms; D000483:Alleles; D000818:Animals; D001499:Bayes Theorem; D044383:Black People / Q000235:genetics; D002875:Chromosomes; D003198:Computer Simulation; D004331:Drosophila melanogaster / Q000235:genetics; D019143:Evolution, Molecular; D005260:Female; D005787:Gene Frequency; D040961:Genetic Drift; D008040:Genetic Linkage; D005819:Genetic Markers; D005828:Genetics, Population; D005838:Genotype; D016480:Helicobacter pylori / Q000235:genetics; D006801:Humans; D008297:Male; D008390:Markov Chains; D008957:Models, Genetic; D009010:Monte Carlo Method; D011995:Recombination, Genetic; D001741:Black or African American
D005819:Genetic Markers