title: Highly enantioselective iridium-catalyzed hydrogenation of heteroaromatic compounds, quinolines.
abstract: The highly enantioselective hydrogenation of quinoline derivatives is developed using [Ir(COD)Cl]2/(R)-MeO-Biphep/I2 system, and this methodology has been applied to the asymmetric synthesis of three naturally occurring alkaloids angustureine, galipinine, and cuspareine. This method provided an efficient access to a variety of optically active tetrahydroquinolines with up to 96% ee.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China.
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Wang
authors.forename: Sheng-Mei
authors.initials: SM
authors.lastname: Lu
authors.forename: Peng-Yu
authors.initials: PY
authors.lastname: Yang
authors.forename: Xiu-Wen
authors.initials: XW
authors.lastname: Han
authors.forename: Yong-Gui
authors.initials: YG
authors.lastname: Zhou
mesh_terms: D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D009942:Organometallic Compounds; D011804:Quinolines; D007495:Iridium