Trophic factors in neurodegenerative disorders.
Neuronal survival is dependent on continuous trophic stimulation by neurotrophic factors. Anterograde and retrograde transport of neurotrophic factors and their receptors within neurites is essential for the communication of these survival signals. Lack of neurotrophic input has been proposed as a pathomechanism leading to neurodegenerative disease. The present short review provides a summary of some of the recent data on neurotrophic factors in neurodegenerative disorders and describes how disturbances of axonal trafficking might deprive neurons from trophic input.
Weis
Joachim
J
Division of Neuropathology, Institute of Pathology, University of Berne, CH-3010 Berne, Switzerland. joachim.weis@pathology.unibe.ch
Saxena
Smita
S
Evangelopoulos
Maria E
ME
Kruttgen
Alex
A
D000818:Animals; D002450:Cell Communication; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000473:pathology / Q000503:physiopathology*; D025801:Ubiquitin / Q000378:metabolism
D006133:Growth Substances; D025801:Ubiquitin