title: New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp.
abstract: Chemical investigation of the two soft corals Nephthea sp. and Sarcophyton cherbonnieri, collected from the Fiji Islands and the Great Barrier Reef, respectively, led to the isolation of three new furano-cembranoids (1-3), two seco-cembranoid acetates (5, 6), along with the known compounds sarcoglaucol (4) and decaryiol (7). The structures of the new compounds were elucidated by employing spectroscopic techniques (NMR, MS, UV, IR and CD). Seco-cembranoids are extremely rare structures. Compounds 1, 3, and 7 were found to be cytotoxic towards several tumor cell lines (GI50 values ranged from 0.15 to 8.6 micrograms mL-1). Compound 7 arrests the cell cycle in the G2/M phase.
authors.affiliation: Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, D-53115 Bonn, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Gross
authors.forename: Stefan
authors.initials: S
authors.lastname: Kehraus
authors.forename: Markus
authors.initials: M
authors.lastname: Nett
authors.forename: Gabriele M
authors.initials: GM
authors.lastname: König
authors.forename: Winfried
authors.initials: W
authors.lastname: Beil
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Wright
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005367:Fiji; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D003603:Cytotoxins; D004224:Diterpenes