title: [Associations of Rsa I polymorphism at the 5' flanking region of CYP2E1 and PON2 148 polymorphism in neonates with preterm delivery].
abstract: The objective is to investigate whether Rsa I polymorphism at the 5' flanking region of cytochrome P450 2E1 gene (CYP2E1) and paraoxonase 2 gene polymorphism (PON2 148) in neonates are associated with preterm delivery. Using standard questionnaires, 209 singleton live born mother-neonate pairs (include preterm cases and term controls) were investigated by the trained field workers with cross-sectional survey at the hospitals in Anqing, Anhui Province, China. Epidemiological and clinical data and blood samples were obtained from 209 mother-neonate pairs. CYP2E1 homozygous wild-type (+/+) is not associated with a shortened gestation among neonates, compared with CYP2E1 homozygous mutant-type (-/-)/CYP2E1 heterozygote (+/-) before and after adjustment confounders, however, PON2 Ala148Ala homozygote is significantly associated with a shortened gestation among neonates. When Rsa I polymorphism at the 5' flanking region of CYP2E1 and PON2 148 polymorphism were considered jointly, a significant shortened gestation was observed among neonates with the combined genotype of CYP2E1 homozygous wild-type and PON2 Ala148Ala homozygote. In conclusion, Rsa I polymorphism at the 5' flanking region of CYP2E1 in neonates is not associated with preterm delivery, however, PON2 148 polymorphism in neonates is significantly associated with preterm delivery. Furthermore, the gene interaction between Rsa I polymorphism at the 5' flanking region of CYP2E1 and PON2 148 polymorphism in neonates is significantly associated with preterm delivery.
authors.affiliation: Department of Biology & Genetics, Peking University Health Science Center, Beijing 100083, China. baiyanwu@public.fhnet.cn.net
authors.forename: Bai-Yan
authors.initials: BY
authors.lastname: Wu
authors.forename: Hong-Ye
authors.initials: HY
authors.lastname: Liang
authors.forename: Da-Fang
authors.initials: DF
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Hu
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Gui-Xiang
authors.initials: GX
authors.lastname: Wang
authors.forename: Xi-Ping
authors.initials: XP
authors.lastname: Xu
mesh_terms: D024506:5' Flanking Region / Q000235:genetics*; D043303:Aryldialkylphosphatase / Q000235:genetics*; D001665:Binding Sites / Q000235:genetics; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D004247:DNA / Q000235:genetics / Q000378:metabolism; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D016015:Logistic Models; D008297:Male; D011110:Polymorphism, Genetic; D011795:Surveys and Questionnaires
chemical_list: D004247:DNA; D019392:Cytochrome P-450 CYP2E1; D015252:Deoxyribonucleases, Type II Site-Specific; C040158:GTAC-specific type II deoxyribonucleases; D043303:Aryldialkylphosphatase; C468411:PON2 protein, human