Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer.
The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population-dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within a Japanese population. Fifty-seven women with HPV16-positive cervical cancer were analyzed for E6 sequence variation and its relationship to HLA class II alleles. Compared with local controls (n = 138) and published controls (n = 916), DRB1*1501 and DQB1*0602 frequencies were significantly increased among patients with HPV16 E6 prototype (n = 11). Additionally, DRB1*1502 was positively associated with a particular E6 variant designated D25E (n = 25), although we could not find a significant association between HLA class II alleles and L83V variants (n = 16). Our observations suggest that a specific match between E6 variant proteins and HLA types may contribute to HPV16-related cervical carcinogenesis.
Matsumoto
Koji
K
Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan. matsumok@mui.biglobe.ne.jp
Yasugi
Toshiharu
T
Nakagawa
Shunsuke
S
Okubo
Mitsuo
M
Hirata
Ranko
R
Maeda
Hiroo
H
Yoshikawa
Hiroyuki
H
Taketani
Yuji
Y
D002278:Carcinoma in Situ / Q000453:epidemiology / Q000378:metabolism / Q000821:virology; D016022:Case-Control Studies; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D005802:Genes, MHC Class II; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D009154:Mutation / Q000235:genetics*; D009361:Neoplasm Invasiveness; D009856:Oncogene Proteins, Viral / Q000145:classification / Q000235:genetics*; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology; D011110:Polymorphism, Genetic; D012097:Repressor Proteins; D012307:Risk Factors; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014412:Tumor Virus Infections / Q000150:complications / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000378:metabolism / Q000821:virology*
D004279:DNA, Viral; C068651:E6 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; D012097:Repressor Proteins