title: Synthesis and antibacterial activity of 1,3-diarylpyrimido[4,5-d]pyrimidines.
abstract: This paper describes the synthesis of 4,5-diaminoderivatives of pyrimidine and pyrimido [4,5-d] pyrimidines and evaluation of their antibacterial activity on 9 selected bacterial species relatif the changes in the chemical structure to an increase in the bioactive properties.
authors.affiliation: Department of Organic Chemistry, Medical Academy, Wroclaw, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Cieplik
authors.forename: J
authors.initials: J
authors.lastname: Pluta
authors.forename: O
authors.initials: O
authors.lastname: Gubrynowicz
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007202:Indicators and Reagents; D011744:Pyrimidinones