Host cell fate on Cryptosporidium parvum egress from MDCK cells.
Cryptosporidium parvum is an intracellular protozoan parasite that causes a severe diarrheal illness of unclear etiology. Also unclear is the fate of the host cell upon parasite egress. We show in an MDCK cell model that the host cell is killed upon parasite egress; this death is necrotic, rather than apoptotic, in nature.
Elliott
David A
DA
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Clark
Douglas P
DP
D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D003457:Cryptosporidiosis / Q000209:etiology / Q000469:parasitology / Q000473:pathology; D016785:Cryptosporidium parvum / Q000472:pathogenicity*; D003967:Diarrhea / Q000209:etiology; D004285:Dogs; D008856:Microscopy, Fluorescence; D009336:Necrosis; D013997:Time Factors