title: Transcutaneous cervical root stimulation in the diagnosis of multifocal motor neuropathy with conduction block.
abstract: OBJECTIVE
  To determine if transcutaneous electrical stimulation of the cervical roots can be used to diagnose proximal conduction block (CB) in multifocal motor neuropathy (MMN) and whether it can reliably distinguish MMN from amyotrophic lateral sclerosis (ALS).
  
  
  METHODS
  Compound muscle action potentials (CMAPs) over the abductor digiti minimi (ADM) were evoked by supramaximal stimulation of the ulnar nerve at the wrist, below elbow, above elbow, axilla, Erb's point, and C8/T1 cervical roots in three groups of patients: 31 patients with ALS, nine patients with MMN, and 31 controls. Supramaximal stimulation at Erb's point and the C8/T1 roots was carried out using a transcutaneous high voltage electrical stimulator. The negative peak amplitude, area, and duration of the CMAP were measured and normalised to that from the wrist. The percentage change in each segment in these parameters was calculated and compared between the different groups.
  
  
  RESULTS
  At stimulation sites proximal to the elbow, there were no significant differences in relative CMAP amplitude, area, or duration between controls, ALS patients, and MMN patients with clinically unaffected ulnar nerves. Similarly, the percentage segmental change between adjacent stimulation sites showed no significant differences. In six studies of MMN patients with weakness in ulnar hand muscles, the decrease in CMAP amplitude between the C8/T1 roots and Erb's point exceeded the mean + 2 SD of the control data.
  
  
  CONCLUSIONS
  Cervical root stimulation can quantify CB in the most proximal segment of the ulnar nerve, a fall in CMAP amplitude if greater than 25%, indicating block, and should be used routinely in the evaluation of patients suspected of having MMN, especially when distal stimulation has proved unhelpful.
authors.affiliation: Academic Neurosciences Centre, King's College Hospital, London, UK.
authors.forename: R
authors.initials: R
authors.lastname: Arunachalam
authors.forename: A
authors.initials: A
authors.lastname: Osei-Lah
authors.forename: K R
authors.initials: KR
authors.lastname: Mills
mesh_terms: D000200:Action Potentials; D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis*; D002574:Cervical Vertebrae; D003937:Diagnosis, Differential; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000175:diagnosis*; D009431:Neural Conduction; D012680:Sensitivity and Specificity; D013126:Spinal Nerve Roots / Q000473:pathology / Q000502:physiology*