title: Pathology of toxoplasmosis in captive new world primates.
abstract: Clinical information was available for 32 of 33 New World primates with fatal toxoplasmosis, all of which were subjected to a variable number of pathological observations. Death without apparent clinical signs occurred in 43.7% of cases. The most common clinical findings were malaise (40.6%), dyspnoea (18.7%), hypothermia (15.6%) and a sero-sanguinous or foamy nasal discharge (12.5%). Nutritional status was good in 71.8%, average in 18.7% and poor in 9.4%. The most common post-mortem findings were pulmonary congestion (78.8%), pulmonary oedema (75.8%), splenomegaly (57.6%) and mesenteric lymphadenitis (54.6%). The most common histopathological findings were multifocal necrotic hepatitis (97%), lymphadenitis (95.4%), interstitial pneumonia (90.3%) and necrotic splenitis (71.4%). The gross post-mortem changes in cebids were more variable than those observed in callitrichids, a fact that may complicate the diagnosis of toxoplasmosis in cebids.
authors.affiliation: Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo. Av. Prof. Dr Orlando Marques de Paiva 87, Cidade Universitária, CEP 05508-900 São Paulo SP, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Epiphanio
authors.forename: I L
authors.initials: IL
authors.lastname: Sinhorini
authors.forename: J L
authors.initials: JL
authors.lastname: Catão-Dias
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D002427:Cebidae; D005260:Female; D006486:Hemosiderosis / Q000473:pathology / Q000662:veterinary; D007124:Immunoenzyme Techniques / Q000379:methods / Q000662:veterinary; D008109:Liver Diseases, Parasitic / Q000276:immunology / Q000473:pathology / Q000662:veterinary; D008174:Lung Diseases, Parasitic / Q000276:immunology / Q000473:pathology / Q000662:veterinary; D008297:Male; D008992:Monkey Diseases / Q000401:mortality / Q000469:parasitology / Q000473:pathology*; D014122:Toxoplasma / Q000276:immunology / Q000302:isolation & purification* / Q000648:ultrastructure; D014124:Toxoplasmosis, Animal / Q000401:mortality / Q000469:parasitology / Q000473:pathology*