title: Cross coupling reactions of organozinc iodides with solid-supported electrophiles: synthesis of 4-substituted benzoic and 3-substituted (E)- and (Z)-propenoic acids and amides.
abstract: The solid-supported iodobenzoic acid derivatives 8-10 were coupled with a range of organozinc reagents 1-4 under palladium(o) catalysis. The coupled products released by acidic cleavage with TFA were obtained in high purities after recrystallisation. Analogous coupling of solid-supported (E)- and (Z)-3-iodoacrylic acids 18a, 18b, 19 and 20 gave (E)- and (Z)-alpha,beta-unsaturated acids and amides 21-27 stereospecifically.
authors.affiliation: Department of Chemistry, Bedson Building, University of Newcastle, Newcastle upon Tyne, UK NE1 7RU.
authors.forename: Leslie J
authors.initials: LJ
authors.lastname: Oates
authors.forename: Richard F
authors.initials: RF
authors.lastname: Jackson
authors.forename: Michael H
authors.initials: MH
authors.lastname: Block