Triquinanes from linear alkylidene carbenes via trimethylenemethane diyls.
The intramolecular [2+3] cycloaddition reaction of the trimethylenemethane diyl generated from the intramolecular cyclopropanation reaction of alkylidene carbene produced linearly fused triquinanes regio- and stereoselectively. The current tandem cycloaddition reaction was applied to a 14-step total synthesis of hirsutene from methallyl alcohol.
Lee
Hee-Yoon
HY
Center for Molecular Design & Synthesis, School of Molecular Science (BK21) and Department of Chemistry, Korea Advanced Institute of Science & Technology, Daejon, 305-701, Korea. leehy@kaist.ac.kr
Kim
Yeonjoon
Y