title: [Hygienic aspects of employment of old age group individuals in chemical industry].
abstract: Due to the fact that a lot of pre-pension and pension-aged individuals are engaged in chemical industry, the age-specific features of lipid peroxidation (LPO) and antioxidative defense (AOD) were studied in an experiment on animals exposed to toluylene diisocyanate (TDI) at the levels of MAC and 1/2 MAC. The experimental findings support that decreased LPO and suppressed AOD occur with age which lower the efficiency of detoxification of chemicals in the body. A wave-shaped pattern of changes has been revealed in these systems in old (8.5-month) animals. At the beginning of exposure to TDI (within the first 2 weeks), there was an increase in LPO and AOD, then a reduction in their activity. Long-term exposure may bring about an impairment of adaptive mechanisms, which is suggested by the parameters characterizing the state of LPO and AOD after a loading test. The findings are indicative of the necessity of monitoring and correcting these parameters in old workers who are in contact with chemicals.
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Feklina
authors.forename: I V
authors.initials: IV
authors.lastname: Fedotova
authors.forename: T V
authors.initials: TV
authors.lastname: Vasil'eva
authors.forename: S A
authors.initials: SA
authors.lastname: Ashirova
authors.forename: V M
authors.initials: VM
authors.lastname: Blagodatin
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D000818:Animals; D002374:Catalase / Q000097:blood; D002617:Chemical Industry; D004651:Employment; D005609:Free Radicals / Q000097:blood; D015386:Hazardous Substances / Q000009:adverse effects*; D006801:Humans; D015227:Lipid Peroxidation; D016272:Occupational Health; D018384:Oxidative Stress; D051381:Rats
chemical_list: D005609:Free Radicals; D015386:Hazardous Substances; D002374:Catalase