title: Antifungal flavanones and prenylated hydroquinones from Piper crassinervium Kunth.
abstract: Bioactivity-guided fractionation of the EtOAc extract from leaves of Piper crassinervium yielded three prenylated hydroquinones together with two known flavanones naringenin and sakuranetin. Their structures were determined by means of spectroscopic analysis (NMR, IR, UV and MS) including two-dimensional NMR spectroscopy experiments (1H-1H COSY, HMQC, HMBC and NOESY). The antifungal activity was determined by direct bioautography against Cladosporium cladosporioides and C. sphaerospermum.
authors.affiliation: Instituto de Química, Universidade de São Paulo, C.P. 26077, CEP 05599-970, São Paulo, SP, Brazil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Danelutte
authors.forename: João Henrique G
authors.initials: JH
authors.lastname: Lago
authors.forename: Maria Claudia M
authors.initials: MC
authors.lastname: Young
authors.forename: Massuo J
authors.initials: MJ
authors.lastname: Kato
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002963:Cladosporium / Q000187:drug effects; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006873:Hydroquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D026321:Piperaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D000094162:Phytoalexins
chemical_list: D000935:Antifungal Agents; D044950:Flavanones; D005419:Flavonoids; D006873:Hydroquinones; D010936:Plant Extracts; C099724:sakuranetin; D000094162:Phytoalexins; C005273:naringenin