Review article: rebamipide and the digestive epithelial barrier.
Rebamipide exerts a positive effect on the digestive epithelial barrier by reinforcing its integrity in normal and in inflammatory conditions, and by normalizing the macromolecular transport across this barrier, increased by Helicobacter infection. Moreover, in mice, rebamipide is capable of diminishing allergic sensitization and of counteracting the inhibitory effect of Helicobacter pylori on oral tolerance to dietary antigens. These properties of rebamipide could explain its anti-inflammatory activity with respect to the digestive mucosa and could provide protection against allergic sensitization to foreign antigens in susceptible individuals.
Matysiak-Budnik
T
T
INSERM EMI-0212, Faculté de Médecine Necker-Enfants Malades, Paris, France. matysiak@necker.fr
Heyman
M
M
Mégraud
F
F
D000409:Alanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology*; D000897:Anti-Ulcer Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D000942:Antigens, Bacterial / Q000378:metabolism; D001692:Biological Transport; D004064:Digestive System / Q000187:drug effects* / Q000276:immunology; D004847:Epithelial Cells / Q000276:immunology / Q000378:metabolism; D016480:Helicobacter pylori / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D015363:Quinolones / Q000493:pharmacokinetics / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D000942:Antigens, Bacterial; D015363:Quinolones; C052785:rebamipide; D000409:Alanine