Highly enantioselective catalytic asymmetric hydrogenation of beta-keto esters in room temperature ionic liquids.
Polar phosphonic acid-derived Ru-BINAP systems were used to catalyze asymmetric hydrogenation of beta-keto esters in room temperature ionic liquids (RTILs) with complete conversions and ee values higher than those obtained from homogeneous reactions in MeOH (up to 99.3%), and were recycled by simple extraction and used for four times without the loss of activity and enantioselectivity.
Ngo
Helen L
HL
Department of Chemistry, CB#3290, University of North Carolina, Chapel Hill, NC 27599, USA.
Hu
Aiguo
A
Lin
Wenbin
W