Viscoelastic evaluation of topical creams containing microcrystalline cellulose/sodium carboxymethyl cellulose as stabilizer.
The purpose of this study was to examine the viscoelastic properties of topical creams containing various concentrations of microcrystalline cellulose and sodium carboxymethyl cellulose (Avicel(R) CL-611) as a stabilizer. Avicel CL-611 was used at 4 different levels (1%, 2%, 4%, and 6% dispersion) to prepare topical creams, and hydrocortisone acetate was used as a model drug. The viscoelastic properties such as loss modulus (G"), storage modulus (G'), and loss tangent (tan delta) of these creams were measured using a TA Instruments AR 1000 Rheometer and compared to a commercially available formulation. Continuous flow test to determine the yield stress and thixotropic behavior, and dynamic mechanical tests for determining the linear viscosity time sweep data, were performed. Drug release from the various formulations was studied using an Enhancer TM Cell assembly. Formulations containing 1% and 2% Avicel CL-611 had relative viscosity, yield stress, and thixotropic values that were similar to those of the commercial formulation. The elastic modulus (G') of the 1% and 2% formulation was relatively high and did not cross the loss modulus (G"), indicating that the gels were strong. In the commercial formulation, G' increased after preshearing and broke down after 600 seconds. The strain sweep tests showed that for all formulations containing Avicel CL-611, the G' was above G" with a good distance between them. The gel strength and the predominance of G' can be ranked 6% > 4% > 2%. The strain profiles for the 1% and 2% formulations were similar to those of the commercial formulation. The delta values for the 1% and 2% formulations were similar, and the formulations containing 4% Avicel CL-611 had lower delta values, indicating greater elasticity. Drug release from the commercial preparation was fastest compared to the formulations prepared using Avicel CL-611, a correlation with the viscoelastic properties. It was found that viscoelastic data, especially the strain sweep profiles of products containing Avicel CL-611 1% and 2%, correlated with the commercial formulation. Rheological tests that measure the viscosity, yield stress, thixotropic behavior, other oscillatory parameters such as G' and G" are necessary tools in predicting performance of semisolids.
Adeyeye
Moji Christianah
MC
Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA 15282, USA. adeyeyechri@duq.edu
Jain
Ashwinkumar C
AC
Ghorab
Mohamed K M
MK
Reilly
William J
WJ
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000378:metabolism / Q000528:radiation effects; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D002482:Cellulose / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004356:Drug Storage / Q000379:methods; D004548:Elasticity / Q000528:radiation effects; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D009823:Ointment Bases / Q000737:chemistry* / Q000378:metabolism / Q000528:radiation effects; D012212:Rheology / Q000379:methods; D013314:Stress, Mechanical; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods; D014783:Viscosity / Q000528:radiation effects
D000893:Anti-Inflammatory Agents; D009823:Ointment Bases; C021650:hydrocortisone acetate; D002482:Cellulose; D002266:Carboxymethylcellulose Sodium; C109691:microcrystalline cellulose; D006854:Hydrocortisone