Desensitization of H2-like histamine receptors stimulating cyclic AMP formation in the chick cerebral cortex.
Histamine potently stimulates cyclic AMP formation in slices of the chick cerebral cortex. Pretreatment of the tissue slices with 10 microM histamine for 2-30 min led to a time-dependent attenuation (when compared with values observed in the control tissue) of the cyclic AMP response produced by subsequent re-stimulation with 1, 10 or 100 microM histamine. The observed histamine-induced desensitization appears to be specific and homologous as the increase in cyclic AMP formation evoked by both forskolin or pituitary adenylate cyclase-activating polypeptide (PACAP) in slices pretreated with 10 microM histamine for 15 min was unchanged. It is concluded that in the chick cerebral cortex, H2-like receptors linked to cyclic AMP-generating system undergo rapid homologous desensitization.
Sedkowska
Paulina
P
Department of Biogenic Amines, Polish Academy of Sciences, POB-225, PL 90-950 Lódź, Poland.
Zawilska
Jolanta B
JB
Nowak
Jerzy Z
JZ
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D002645:Chickens; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000096:biosynthesis / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011970:Receptors, Histamine H2 / Q000378:metabolism* / Q000502:physiology; D013997:Time Factors
D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011970:Receptors, Histamine H2; D005576:Colforsin; D006632:Histamine; D000242:Cyclic AMP