Role of humoral factors in the regulation of hemopoiesis during cytostatic-induced myelosuppression.
The content of hemopoietic precursors in the bone marrow, its morphological composition, production of hemopoietic growth factors by cells of the hemopoietic microenvironment, erythropoietic activity, and plasma content of endogenous erythropoietin were studied in CBA/CaLac mice with hypoplasia of hemopoiesis induced by adriamycin in a maximum permissible dose. Cytostatic treatment affected production of substances determining erythropoietic activity by adherent and nonadherent cells of the bone marrow. Erythropoietic activity of peripheral blood plasma considerably increased. Recovery of erythroid hemopoiesis was determined by the effects of endogenous erythropoietin and other substances secreted by cells of the hemopoietic microenvironment and present in the peripheral blood.
Dygai
A M
AM
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Zhdanov
V V
VV
Simanina
E V
EV
Gur'yantseva
L A
LA
Udut
E V
EV
Khrichkova
T Yu
TY
Kirienkova
E V
EV
Epstein
O I
OI
Gol'dberg
E D
ED
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001773:Blood Cells / Q000166:cytology / Q000502:physiology; D004317:Doxorubicin / Q000494:pharmacology*; D004920:Erythropoiesis / Q000187:drug effects* / Q000502:physiology*; D004921:Erythropoietin / Q000097:blood; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D004921:Erythropoietin; D004317:Doxorubicin