title: Use of pi-allyltricarbonyliron lactone complexes in the synthesis of taurospongin A: a potent inhibitor of DNA polymerase beta and HIV revers transcriptase.
abstract: The total synthesis of taurospongin A by two new approaches has been achieved where pi-allyltricarbonyliron lactone complexes have been used to control highly stereoselective additions of the nucleophiles to a carbonyl unit located in the side chain of these complexes.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Hollowood
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yamanoi
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000494:pharmacology; D019951:DNA Polymerase beta / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D004952:Esters / Q000138:chemical synthesis* / Q000494:pharmacology; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D058085:Iron Compounds / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D004791:Enzyme Inhibitors; D004952:Esters; D058085:Iron Compounds; D007783:Lactones; D018894:Reverse Transcriptase Inhibitors; C464964:taurospongin A; D054303:HIV Reverse Transcriptase; D019951:DNA Polymerase beta