title: [Changes in the expression of cellular alpha and beta tubulins in patients with sporadic type colorectal cancer].
abstract: The aim of this preliminar report is to evaluate alfa and beta tubulins, components of cellular microtubules, alterated expression in sporadic colorectal cancer patients. The Authors considered 16 patients who underwent surgery for sporadic colorectal carcinoma with radical intent. Alfa and beta tubulins were evaluated in tumoral mucosa by immunohistochemistry. In 56.2% of the examined patients a low expression of alfa and beta tubulins was showed while the alteration of alfa tubulin was showed in 81.2% of the patients. This finding supports the hypothesis of Porter that alterations in microtubule structure might be part of the cellular response to DNA damage.
authors.affiliation: II Facoltà di Medicina e Chirurgia Chirurgia Generale B, Ospedale Sant'Andrea, Università degli Studi La Sapienza, Roma.
authors.forename: G
authors.initials: G
authors.lastname: Midiri
authors.forename: E
authors.initials: E
authors.lastname: Giarnieri
authors.forename: A
authors.initials: A
authors.lastname: Covotta
authors.forename: G
authors.initials: G
authors.lastname: Soda
authors.forename: G
authors.initials: G
authors.lastname: Tucci
authors.forename: F
authors.initials: F
authors.lastname: Consorti
authors.forename: M
authors.initials: M
authors.lastname: Pacella
authors.forename: S
authors.initials: S
authors.lastname: Gidaro
authors.forename: L
authors.initials: L
authors.lastname: Covotta
authors.forename: L
authors.initials: L
authors.lastname: Luzzatto
authors.forename: V A
authors.initials: VA
authors.lastname: Cirolla
authors.forename: S
authors.initials: S
authors.lastname: Conte
authors.forename: G
authors.initials: G
authors.lastname: Marino
authors.forename: A
authors.initials: A
authors.lastname: Vecchione
authors.forename: V
authors.initials: V
authors.lastname: Beltrami
mesh_terms: D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014404:Tubulin / Q000096:biosynthesis*
chemical_list: D014404:Tubulin