title: Hypereosinophilia associated with cardiac rhabdomyosarcoma.
abstract: Hypereosinophilia, defined as an absolute eosinophil count exceeding 1,500/mm(3), is caused by a limited number of disorders. Its association with malignancy is a rare occurrence that typically denotes extensive metastasis and a poor prognosis. Several theories have been proposed to explain the hypereosinophilia associated with malignancy, focusing on the production of eosinophilopoietic cytokines by tumors. We describe a patient with hypereosinophilia associated with a cardiac rhabdomyosarcoma, review the etiologies of hypereosinophilia, and discuss the possible mechanisms.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. vincent.lore@uphs.upenn.edu
authors.forename: Vincent
authors.initials: V
authors.lastname: Lo Re
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Fox
authors.forename: Victor A
authors.initials: VA
authors.lastname: Ferrari
authors.forename: Craig H
authors.initials: CH
authors.lastname: Scott
authors.forename: Plamen M
authors.initials: PM
authors.lastname: Kossev
authors.forename: Jay R
authors.initials: JR
authors.lastname: Kostman
mesh_terms: D000328:Adult; D004452:Echocardiography; D005260:Female; D006338:Heart Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000209:etiology*; D007238:Infarction / Q000000981:diagnostic imaging / Q000209:etiology; D012079:Renal Circulation; D012208:Rhabdomyosarcoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D013154:Spleen / Q000098:blood supply; D014057:Tomography, X-Ray Computed