Facile synthesis of flavonoid 7-O-glycosides.
Highly regioselective removal of the 7-O-acyl groups of the peracylated flavones, isoflavones, and flavonols (PhSH, imidazole, NMP) followed by effective glycosylation with glycosyl trifluoroacetimidates (BF(3).Et(2)O) and cautious deprotection of the acyl groups under basic conditions afforded the desired 7-O-flavonoid glycosides in satisfactory yields.
Li
Ming
M
State Key Laboratory of Catalyst, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Han
Xiuwen
X
Yu
Biao
B
D002236:Carbohydrate Conformation; D005419:Flavonoids; D006026:Glycoside Hydrolases / Q000138:chemical synthesis*; D007093:Imidazoles; D007202:Indicators and Reagents
D005419:Flavonoids; D007093:Imidazoles; D007202:Indicators and Reagents; D006026:Glycoside Hydrolases