title: A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice.
abstract: We have studied the genetics of susceptibility to infection by Streptococcus pneumoniae in mice. Linkage analysis of the F(2) generation from a cross between resistant BALB/cO1aHsd and susceptible CBA/CaO1aHsd strains allowed us to map a major locus controlling the development of bacteremia and survival after intranasal infection.
authors.affiliation: MRC UK Mouse Genome Centre & Mammalian Genetics Unit, Harwell, Oxon, OX11 0RD, UK. paul@har.mrc.ac.uk
authors.forename: Paul
authors.initials: P
authors.lastname: Denny
authors.forename: Elaine
authors.initials: E
authors.lastname: Hopes
authors.forename: Neill
authors.initials: N
authors.lastname: Gingles
authors.forename: Karl W
authors.initials: KW
authors.lastname: Broman
authors.forename: William
authors.initials: W
authors.lastname: McPheat
authors.forename: John
authors.initials: J
authors.lastname: Morten
authors.forename: Janet
authors.initials: J
authors.lastname: Alexander
authors.forename: Peter W
authors.initials: PW
authors.lastname: Andrew
authors.forename: Steve D M
authors.initials: SD
authors.lastname: Brown
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D011008:Pneumococcal Infections / Q000235:genetics*; D013296:Streptococcus pneumoniae