Neuroimaging of serotonin transporters in post-stroke pathological crying.
Pathological crying (PC) is a neuropsychiatric disorder characterized by an excessive tendency towards crying after brain damage. To elucidate the role of serotonin neurotransmission for PC, a pilot study was performed using single photon emission computed tomography with [123I]beta-CIT to estimate central (midbrain/pons and thalamus/hypothalamus) serotonin transporter (SERT) densities in 15 stroke patients who did or did not have PC. SERT binding ratios in midbrain/pons were significantly lower in the PC subgroup.
Murai
Toshiya
T
Max-Planck-Institute of Cognitive Neuroscience, Stephanstr. 1, D-04103 Leipzig, Germany.
Barthel
Henryk
H
Berrouschot
Jörg
J
Sorger
Dietlind
D
von Cramon
D Yves
DY
Müller
Ulrich
U
D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D002352:Carrier Proteins / Q000378:metabolism*; D003042:Cocaine / Q000031:analogs & derivatives*; D003448:Crying / Q000523:psychology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D010865:Pilot Projects; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins; D020521:Stroke / Q000378:metabolism* / Q000473:pathology*; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; C069723:2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; D003042:Cocaine