title: Initial evaluation of commercial optical CT-based 3D gel dosimeter.
abstract: We evaluated the OCTOPUS-ONE research laser CT scanner developed and manufactured by MGS Research, Inc. (Madison, CT). The scanner is designed for imaging 3D optical density distributions in BANG gels. The scanner operates in a translate-rotate configuration with a single scanning laser beam. The rotating cylindrical gel phantom is immersed in a refractive index matching solution and positioned at the center of a square tank made of plastic and glass. A stationary polarized He-Ne laser beam (633 nm) is reflected from a mirror moving parallel to the tank wall and scans the gel. Another mirror moves synchronously along the opposite side of the tank and collects the transmitted light and sends it to a single stationary silicon photodetector. A filtered backprojection algorithm is used to reconstruct projection data in a plane. The laser-mirrors-detector assembly is mounted on a horizontal platform that moves vertically for slice selection. We have tested the mechanical and optical setup, projection centering on the axis of rotation, linearity, and spatial resolution. We found the optical detector to respond linearly to transmitted light from control samples. The spatial resolution of the scanner was determined by employing a split field resolution technique. We obtained the horizontal and vertical full widths at half maxima of the laser beam intensity profiles as 0.6 and 0.8 mm, respectively. Dose calibration tests of the gel were performed using a nine-field (2 x 2 cm2 each) dose pattern irradiated at different dose levels. Finally, we compared gel-derived 2D planar dose distribution against radiochromic film measured dose distribution for both the nine-field and a uniform 5 x 5 cm2 field of 6 MV x rays. Very similar dose distributions were observed in gel and radiochromic film except in regions of steep dose gradient and highest dose. A dose normalization of 15.6% was required between the two dosimeters due to differences in overall radiation response. After normalization, analysis using the gamma evaluation showed that the radiochromic film and gel-measured dose distributions differed by a maximum gamma of 1.3 using 5% and 1.5 mm dose difference and distance-to-agreement criteria. The optical CT scanner has great potential as a 3D dosimeter, but a few refinements and further testing are necessary before its routine clinical use.
authors.affiliation: Department of Radiation Oncology, Mallinckrodt Institute, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: K T S
authors.initials: KT
authors.lastname: Islam
authors.forename: James F
authors.initials: JF
authors.lastname: Dempsey
authors.forename: Manisha K
authors.initials: MK
authors.lastname: Ranade
authors.forename: Marek J
authors.initials: MJ
authors.lastname: Maryanski
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Low
mesh_terms: D000465:Algorithms; D002138:Calibration; D005069:Evaluation Studies as Topic; D005373:Film Dosimetry; D005720:Gamma Rays; D005782:Gels; D005898:Glass; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007834:Lasers; D008027:Light; D019047:Phantoms, Imaging; D010969:Plastics; D011874:Radiometry / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014962:X-Ray Film
chemical_list: D005782:Gels; D010969:Plastics