title: Trial design and patient safety--the debate continues.
authors.forename: Robert
authors.initials: R
authors.lastname: Steinbrook
mesh_terms: D002986:Clinical Trials as Topic / Q000941:ethics / Q000331:legislation & jurisprudence / Q000592:standards*; D028744:Ethics Committees, Research / Q000331:legislation & jurisprudence; D005440:Fluid Therapy; D006801:Humans; D007258:Informed Consent; D012107:Research Design / Q000592:standards*; D012121:Respiration, Artificial / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D013990:Tidal Volume; D014481:United States; D014483:United States Dept. of Health and Human Services