title: [Metallothioneins gene in induced mouse allergic contact dermatitis].
abstract: OBJECTIVE
  To investigate the chronic hypersensitivity (CHS) to dinitrofluorobenzene (DNFB) in metallothionein gene knocked-out (MT -/-) mice and wild mice (MT +/+) with homologous genes.
  
  
  METHODS
  Mice were sensitized by applying DNFB on abdominal skin and CHS was induced on right ears. The CHS was observed by ear swelling.
  
  
  RESULTS
  In comparison with metallothionein--null mice, the ear swelling of normal control wild mice was significantly greater. (P < 0.05, Students t test).
  
  
  CONCLUSIONS
  Metallothioneins play an important role in the CHS. Metallothionein gene knocked-out (MT -/-) mice express less inflammation of CHS.
authors.affiliation: Department of Dermatology, Peking University Third Hospital, China.
authors.forename: Xueyan
authors.initials: X
authors.lastname: Lu
authors.forename: Linfeng
authors.initials: L
authors.lastname: Li
authors.forename: Wenhui
authors.initials: W
authors.lastname: Wang
authors.forename: Baoxu
authors.initials: B
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000235:genetics*; D004139:Dinitrofluorobenzene; D007249:Inflammation; D008668:Metallothionein / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D012867:Skin
chemical_list: D008668:Metallothionein; D004139:Dinitrofluorobenzene