title: Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. Part 4: structure-activity relationships for substituents on the quinazoline moiety of 4-[4-(N-substituted(thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.
abstract: Here, we investigated the structure-activity relationships of the 6,7-dimethoxyquinazoline moiety. With regard to exploration of positions and varieties of substituents on the quinazoline ring, 6,7-dialkoxy substitution was optimal. This study suggests the possibility of further modifications for this moiety.
authors.affiliation: Kyowa Hakko Kogyo Co., Ltd., Pharmaceutical Research Institute, Shimotogari 1188, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8731, Japan. k.matsuno@teijin.co.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsuno
authors.forename: Takashi
authors.initials: T
authors.lastname: Seishi
authors.forename: Takao
authors.initials: T
authors.lastname: Nakajima
authors.forename: Michio
authors.initials: M
authors.lastname: Ichimura
authors.forename: Neill A
authors.initials: NA
authors.lastname: Giese
authors.forename: Jin-Chen
authors.initials: JC
authors.lastname: Yu
authors.forename: Shoji
authors.initials: S
authors.lastname: Oda
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nomoto
mesh_terms: D000818:Animals; D006801:Humans; D020128:Inhibitory Concentration 50; D010766:Phosphorylation / Q000187:drug effects; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017479:Receptors, Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D011799:Quinazolines; D017479:Receptors, Platelet-Derived Growth Factor