Effects of ultralow doses of antibodies to prostate-specific antigen on morphological and functional state of rat prostate.
Morphological and morphometric assays showed that administration of antibodies to the prostate-specific antigen in ultralow doses for 1.5 months delayed the development of atrophic and sclerotic processes in rats with chronic aseptic prostatitis. The concentration of zinc ions playing an important role in binding of androgens increased in the prostate of rats receiving the preparation. Studies of copulatory behavior showed that male rats with chronic prostatitis receiving antibodies to the prostate-specific antigen displayed increased sexual activity compared to control and intact animals.
Borovskaya
T G
TG
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Fomina
T I
TI
Loskutova
O P
OP
Baranova
O V
OV
Sergeeva
S A
SA
Martyushev
A V
AV
Epstein
O I
OI
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D011467:Prostate / Q000187:drug effects* / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000276:immunology*; D011472:Prostatitis; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects
D000906:Antibodies; D017430:Prostate-Specific Antigen