title: Adenocarcinoma arising from a mature cystic teratoma of the testis.
abstract: A 52-year-old male diagnosed pathologically with metastatic adenocarcinoma of the skin was referred to our department. Physical examination revealed a right scrotal mass the size of child's head and several skin tumors. Right high orchiectomy and resection of skin tumors were performed. Histopathological examination revealed a well-differentiated, mucinous adenocarcinoma originating from the gastrointestinal epithelium in a mature cystic teratoma (dermoid cyst) of the testis and metastatic mucinous adenocarcinoma of the skin. We made a diagnosis of teratoma with malignant transformation (TMT) of the testis. Combination chemotherapy with low-dose cisplatin/5'-deoxy-5-fluorouridine (CDDP/5'-DFUR) was initiated, but the patient died 8 months after orchiectomy. At autopsy, similar mucinous adenocarcinoma of the testis and the skin were observed at the metastatic sites.
authors.affiliation: Department of Urology, Tokushima Red Cross Hospital, Tokushima, Japan. nisseki@orange.ocn.ne.jp
authors.forename: Toshinori
authors.initials: T
authors.lastname: Kasai
authors.forename: Kazumichi
authors.initials: K
authors.lastname: Moriyama
authors.forename: Masahito
authors.initials: M
authors.lastname: Tsuji
authors.forename: Kenzo
authors.initials: K
authors.lastname: Uema
authors.forename: Noritsugu
authors.initials: N
authors.lastname: Sakurai
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Fujii
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery; D003884:Dermoid Cyst / Q000175:diagnosis* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D012878:Skin Neoplasms / Q000556:secondary*; D013724:Teratoma / Q000175:diagnosis* / Q000601:surgery; D013736:Testicular Neoplasms / Q000175:diagnosis* / Q000601:surgery