title: Dietary CLA and DHA modify skin properties in mice.
abstract: This study investigated the influence of PUFA on the properties of mouse skin. Mice (3 wk old) were given free access to oils high in linoleic acid, CLA, or DHA for 4 wk. At the end of the experiment, their skins were compared by both biochemical and histological methods. No significant differences in lipid and collagen contents were detected among treatments, although the FA composition in the skin was altered depending upon the FA composition of the supplemented oils. Electron microscopy revealed that the subcutaneous tissue layers in the CLA and DHA groups were significantly thinner than that in the high linoleic acid group, whereas no differences in the thickness of dermis layers were observed among the three groups. These results suggest that skin properties in mice are readily modified by dietary FA sources within 4 wk of dietary oil supplementation.
authors.affiliation: Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Daichi
authors.initials: D
authors.lastname: Oikawa
authors.forename: Tomonori
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Takaya
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Nobuya
authors.initials: N
authors.lastname: Shiba
authors.forename: Manabu
authors.initials: M
authors.lastname: Tobisa
authors.forename: Tomo
authors.initials: T
authors.lastname: Takagi
authors.forename: Hisao
authors.initials: H
authors.lastname: Iwamoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tachibana
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Furuse
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000187:drug effects; D000818:Animals; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D012867:Skin / Q000187:drug effects* / Q000378:metabolism* / Q000648:ultrastructure; D040521:Subcutaneous Tissue / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D044243:Linoleic Acids, Conjugated; D004281:Docosahexaenoic Acids