Lipid membranes with grafted polymers: physicochemical aspects.
Membranes grafted with water-soluble polymers resist protein adsorption and adhesion to cellular surfaces. Liposomes with surface-grafted polymers therefore find applications in drug delivery. The physicochemical properties of polymer-grafted lipid membranes are reviewed with mean-field and scaling theories from polymer physics. Topics covered are: mushroom-brush transitions, membrane expansion and elasticity, bilayer-micelle transitions, membrane-membrane interactions and protein-membrane interactions.
Marsh
Derek
D
Max-Planck-Institut für Biophysikalische Chemie, Abteilung Spektroskopie, Am Fassberg 11, D-37077 Göttingen, Germany. dmarsh@gwdg.de
Bartucci
Rosa
R
Sportelli
Luigi
L
D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000378:metabolism; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism
D008051:Lipid Bilayers; D011108:Polymers; D011506:Proteins; D011092:Polyethylene Glycols