ALK-ATIC fusion in urinary bladder inflammatory myofibroblastic tumor.
In this report, we describe an inflammatory myofibroblastic tumor (IMT) of the urinary bladder in a 46-year-old man. Tumor cells presented striking cytoplasmatic ALK immunopositivity. Cytogenetic and FISH analysis, by use of a multicolor chromosome 2 banding probe, revealed a 46,XY,der(2)(2pter-->2p23:2q35-->2q37:2p11-->2q35:2p23-->2p11:2q37-->2qter) karyotype. Subsequent FISH and RT-PCR analysis confirmed the ALK-ATIC chimeric fusion in tumor cells. This is the first evidence of a variant rearrangement involving the ATIC gene in IMT and the first cytogenetic description of an IMT originating from the urinary bladder.
Debiec-Rychter
Maria
M
Center for Human Genetics, University of Leuven, Leuven, Belgium. Maria.Debiec-Rychter@med.kuleuven.ac.be
Marynen
Peter
P
Hagemeijer
Anne
A
Pauwels
Patrick
P
D000077548:Anaplastic Lymphoma Kinase; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000201:enzymology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009379:Neoplasms, Muscle Tissue / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology; D009709:Nucleotide Deaminases / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases; D001749:Urinary Bladder Neoplasms / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology
D015514:Oncogene Proteins, Fusion; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; D009709:Nucleotide Deaminases; C021436:IMP cyclohydrolase