Peripheral T-cell lymphoma associated consecutively with hemophagocytic lymphohistiocytosis and hypereosinophilic syndrome.
Both hemophagocytic lymphohistiocytosis and hypereosinophilic syndrome have been associated with hematologic neoplasms and are respectively related to an overproduction of the cytokines Thelper 1 (Th1) and Th2 by tumor cells or reactive cells. To our knowledge, this is the first time a case of a peripheral T-cell lymphoma consecutively associated with both paraneoplastic conditions has been reported. Importantly, in this case when the lymphoma exclusively involved the bone marrow, severe paraneoplastic systemic damage, a CD8+ suppressor/cytotoxic phenotype and a hypereosinophilia not related to high levels of interleukin (IL)-5 was found. Interestingly, progression of the lymphoma coincided with an increase in the serum levels of several Th2 cytokines and IL-2, a decrease in tumor necrosis factor and granulocyte-macrophage colony-stimulating factor levels and the onset of a hypereosinophilic syndrome.
Gutiérrez
Antonio
A
Hematology and Medical Oncology Department, Pathology Department, Hospital Clínico, University of Valencia, Spain.
Solano
Carlos
C
Ferrández
Antonio
A
Marugán
Isabel
I
Terol
María José
MJ
Benet
Isabel
I
Tormo
Mar
M
Bea
María Dolores
MD
Rodríguez
José
J
D001706:Biopsy; D001854:Bone Marrow Cells / Q000378:metabolism; D017252:CD3 Complex / Q000096:biosynthesis; D016827:CD8 Antigens / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood; D015616:Histiocytosis, Non-Langerhans-Cell / Q000473:pathology*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000473:pathology*; D015848:Interleukin-5 / Q000096:biosynthesis / Q000378:metabolism; D008223:Lymphoma; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications*; D008875:Middle Aged; D010641:Phenotype; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D017252:CD3 Complex; D016827:CD8 Antigens; D015848:Interleukin-5; D016178:Granulocyte-Macrophage Colony-Stimulating Factor