title: Reevaluation of host ranges of feline leukemia virus subgroups.
abstract: We reevaluated the host ranges of feline leukemia virus (FeLV) subgroups A, B and C using pseudotype assays based on recombinant NB-tropic murine leukemia virus, which is not usually blocked after viral entry in mammalian cells. Pseudotype viruses of FeLV-B and -C infected a variety of cell lines from many mammalian species. Unexpectedly, FeLV-A pseudotype viruses of two independent isolates from the UK and US also infected a variety of non-feline cell lines including cells from humans, rabbits, pigs and minks. Moreover, both isolates of FeLV-A productively infected human embryonic kidney 293 and mink Mv-1-Lu cells. We conclude that FeLV-A is not strictly ecotropic.
authors.affiliation: Research Center for Emerging Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Nakata
authors.forename: Takayuki
authors.initials: T
authors.lastname: Miyazawa
authors.forename: Yeon-Sil
authors.initials: YS
authors.lastname: Shin
authors.forename: Rie
authors.initials: R
authors.lastname: Watanabe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mikami
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Matsuura
mesh_terms: D000818:Animals; D002460:Cell Line / Q000821:virology; D006801:Humans; D005256:Leukemia Virus, Feline / Q000145:classification / Q000276:immunology / Q000502:physiology*; D008907:Mink; D011991:Receptors, Virus / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D013552:Swine; D014779:Virus Replication
chemical_list: D011991:Receptors, Virus; D011993:Recombinant Fusion Proteins