[Spectral study on five complexes derived from D-glucosamine and their effect on DNA].
Complexes CuGlu, ZnGlu, NiGlu, Fe(III) Glu, Co(III) Glu where Glu is d-glucosamine have been synthesized. The effects of these compounds on DNA have been studied by the UV-Vis, fluorescence and SERS methods. The possible active ways of these complexes with DNA have been discussed. The results show that the adsorbed state of these complexes on silver sols are similar, and that CuGlu, Co(III) Glu have strong interactions with DNA. Their acting ways on DNA are different. It is worth to do a further research on these compounds as anticancer drugs.
Ye
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Y
Department of Analysis-Measurement Science, Wuhan University, Faculty of Chemistry and Material Science, Hubei University, Wuhan, China.
Hu
J M
JM
Zeng
Y
Y
D000970:Antineoplastic Agents / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004347:Drug Interactions; D005944:Glucosamine / Q000737:chemistry*; D007501:Iron / Q000737:chemistry; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013059:Spectrum Analysis, Raman; D015032:Zinc / Q000737:chemistry
D000970:Antineoplastic Agents; D002614:Chelating Agents; D009942:Organometallic Compounds; D003035:Cobalt; D003300:Copper; D009532:Nickel; D004247:DNA; D007501:Iron; D015032:Zinc; D005944:Glucosamine