title: Basal cell carcinoma with sarcomatoid features (sarcomatoid carcinoma): report of a case and review of the literature.
abstract: We report a new case of sarcomatoid carcinoma, which showed cellular features of basal cell carcinoma and malignant fibrous myxoid histiocytoma. For this new case and rare neoplasm, we propose the designation of sarcomatoid basal cell carcinoma, as both components were intimately intermingled, the spindle cells seemed to arise from epithelial cells, and both tumoral components showed the same immunohistochemistry expression, cytokeratin and P53 protein, suggesting a monoclonal origin. The epithelial component, a basal cell carcinoma, may have been the first component in the carcinogenesis process.
authors.affiliation: Department of Dermatology, Virgen Macarena Hospital, Seville, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Gómez-Espejo
authors.forename: Alberto
authors.initials: A
authors.lastname: Herrera-Sabal
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Ríos-Martín
authors.forename: Francisco
authors.initials: F
authors.lastname: Camacho-Martínez
mesh_terms: D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002296:Carcinosarcoma / Q000473:pathology* / Q000601:surgery; D004431:Ear, External; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53