Effect of preparations from potentiated ethanol on the content of biogenic monoamines and metabolism of ethanol in tissues of rats during alcoholization.
The effect of homeopathically potentiated ethanol (C30 and C200) on ethanol metabolism was studied in alcoholized rats. We measured ethanol concentration in the blood, alcohol dehydrogenase activity in the liver, and contents of biogenic monoamines in the hypothalamus, septum, and whole blood. Potentiated preparations of ethanol were efficient after long-term treatment and delayed ethanol elimination from the blood. Preparation C200 increased alcohol dehydrogenase activity. Potentiated preparations of ethanol (particularly C200) produced a positive effect on catecholaminergic and serotoninergic systems of the brain, i.e. they enhanced protective and adaptive reactions.
Titkova
A M
AM
Institute of Neurology, Psychiatry, and Narcology, Ukrainian Academy of Medical Sciences, Kharkov.
Epstein
O I
OI
D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000818:Animals; D015306:Biogenic Monoamines / Q000097:blood* / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism* / Q000494:pharmacology*; D007031:Hypothalamus; D008099:Liver / Q000201:enzymology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism
D015306:Biogenic Monoamines; D012701:Serotonin; D000431:Ethanol; D000426:Alcohol Dehydrogenase; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine