Control of liposidomycin production through precursor-directed biosynthesis.
Liposidomycin, a potent inhibitor of bacterial peptidoglycan biosynthesis, represents the main component of a group of over 24 closely related, fatty acyl nucleoside antibiotics produced by Streptomyces. Exogeneously supplied myristic acid or palmitic acid resulted in the almost exclusive production of liposidomycin C-(III) and/or M-(III). Exogeneously supplied [1-13C]-palmitic acid was incorporated directly into liposidomycin M-(III) as judged by the FAB-MS and 13C NMR spectra.
Kagami
Shinobu
S
Research Institute of Life Science, Snow Brand Milk Products, Co. Ltd., 519 Ishibashi-machi, Shimotsuga-gun, Tochigi 329-0512, Japan.
Esumi
Yasuaki
Y
Nakakoshi
Masamichi
M
Yoshihama
Makoto
M
Kimura
Ken-ichi
K
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification; D005285:Fermentation; D019814:Myristic Acid / Q000494:pharmacology; D019308:Palmitic Acid / Q000494:pharmacology; D013305:Streptomyces griseus
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C047544:liposidomycins; D019814:Myristic Acid; D019308:Palmitic Acid