Potentiated antibodies against morphine: effects on biogenic amines and lipid peroxidation in chronically morphinized rats.
The efficiency of potentiated antibodies against morphine was studied on the model of chronic morphine intoxication. Test antibodies stimulated catecholamine metabolism in the hypothalamus (i.e., prevented initiation of catecholamine- and histaminergic peripheral reactions) and normalized lipid peroxidation.
Titkova
A M
AM
Institute of Neurology, Psychiatry, and Narcology, Ukrainian Academy of Medical Sciences, Kharkov.
Kharitonova
S M
SM
Pan
I R
IR
Epstein
O I
OI
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D001679:Biogenic Amines / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D009020:Morphine / Q000037:antagonists & inhibitors* / Q000276:immunology; D009021:Morphine Dependence; D051381:Rats
D000906:Antibodies; D001679:Biogenic Amines; D002395:Catecholamines; D009020:Morphine