title: The pterocellins, novel bioactive alkaloids from the marine bryozoan Pterocella vesiculosa.
abstract: Two new alkaloids, pterocellins A and B, have been isolated from the New Zealand marine bryozoan Pterocella vesiculosa. Structural elucidation was achieved through NMR and mass spectral analysis in conjunction with a single-crystal X-ray diffraction study of pterocellin A. The pterocellins possess a novel heterocyclic skeleton and exhibit potent antitumor activity and antimicrobial activity in vitro but only modest activity in the in vivo hollow fiber assay at the National Cancer Institute.
authors.affiliation: Department of Chemistry, University of Waikato, Private Bag 3105, Hamilton, New Zealand.
authors.forename: Biao
authors.initials: B
authors.lastname: Yao
authors.forename: Michèle R
authors.initials: MR
authors.lastname: Prinsep
authors.forename: Brian K
authors.initials: BK
authors.lastname: Nicholson
authors.forename: Dennis P
authors.initials: DP
authors.lastname: Gordon
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002013:Bryozoa / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D006575:Heterocyclic Compounds, 3-Ring; C479813:pterocellin A; C479814:pterocellin B