title: Anterior segment congestion of a right liver lobe graft in living-donor liver transplantation and strategy to prevent congestion.
abstract: OBJECTIVE
  A left lobe graft from a small donor will not usually fulfill the metabolic demands of a larger recipient in adult-to-adult living-donor liver transplantation (LDLT). One solution to this problem is to use a right lobe graft. However, the necessity of middle hepatic vein (MHV) outflow drainage from the anterior segment (AS) of a right lobe graft has not yet been clearly described in the literature. From July 1997 to February 1998, five right lobe grafts without MHV outflow drainage were implanted in five adult recipients. The graft weights ranged from 650 to 1000 g, and their volumes ranged from 48% to 83% of the ideal liver mass of the recipients. Two grafts showed severe congestion of the AS immediately after reperfusion, followed by prolonged massive ascites and severe liver dysfunction in each patient postoperatively. Eventually, one patient died of sepsis, on posttransplant day 20, demonstrating progressive hepatic dysfunction.
  
  
  METHODS
  Subsequently, since March 1998, 176 of 208 adult recipients who received a right lobe graft, while demonstrating sizable (greater than 5-mm diameter) MHV tributaries underwent reconstruction of MHV outflow drainage, using the recipient's own autogenous or cryopreserved cadaveric interposition vein grafts.
  
  
  RESULTS
  In 170 of the 176 recipients, AS congestion was not demonstrated on enhanced liver computerized tomography (CT) or Doppler ultrasonography (USG) postoperatively, and the patency rate of interposition vein grafts was 96.6% on day 30 posttransplant.
  
  
  CONCLUSIONS
  A right lobe graft without MHV outflow drainage might result in severe congestion of the AS, which could lead to the patient's death in an extreme situation. Preservation of MHV outflow drainage in a right lobe graft is possible by two harvesting methods: an extended right lobe (ERL)graft, in which the MHV trunk is included in the graft, and a modified right lobe (MRL) graft, in which venous tributaries of the MHV are reconstructed via interposition vein grafts into the recipient's hepatic venous system. From the viewpoint of donor safety, the ERL graft increases the donor's risk more than the MRL graft, because the remaining left liver lobe of the donor does not possess an MHV. Here, we introduce our experiences of MRL grafts in adult-to-adult LDLTs.
authors.affiliation: Department of General Surgery, Division of Hepato-Biliary Surgery and Liver Transplantation, Asan Medical Center, Ulsan University School of Medicine, Seoul, Korea.
authors.forename: SungGyu
authors.initials: S
authors.lastname: Lee
authors.forename: KwangMin
authors.initials: K
authors.lastname: Park
authors.forename: Shin
authors.initials: S
authors.lastname: Hwang
authors.forename: KiHoon
authors.initials: K
authors.lastname: Kim
authors.forename: ChulSoo
authors.initials: C
authors.lastname: Ahn
authors.forename: DukBok
authors.initials: D
authors.lastname: Moon
authors.forename: JungWoo
authors.initials: J
authors.lastname: Joo
authors.forename: SungHoon
authors.initials: S
authors.lastname: Cho
authors.forename: KiBong
authors.initials: K
authors.lastname: Oh
authors.forename: TaeYong
authors.initials: T
authors.lastname: Ha
authors.forename: HyunSeong
authors.initials: H
authors.lastname: Yang
authors.forename: KyuTaek
authors.initials: K
authors.lastname: Choi
authors.forename: KyuSam
authors.initials: K
authors.lastname: Hwang
authors.forename: EunJoo
authors.initials: E
authors.lastname: Lee
authors.forename: YoungSang
authors.initials: Y
authors.lastname: Lee
authors.forename: HanJoo
authors.initials: H
authors.lastname: Lee
authors.forename: YoungHwa
authors.initials: Y
authors.lastname: Chung
authors.forename: MyungHwan
authors.initials: M
authors.lastname: Kim
authors.forename: SungKoo
authors.initials: S
authors.lastname: Lee
authors.forename: DongJin
authors.initials: D
authors.lastname: Suh
authors.forename: KyuBo
authors.initials: K
authors.lastname: Sung
mesh_terms: D000328:Adult; D006498:Hepatectomy / Q000379:methods; D006503:Hepatic Veins / Q000601:surgery; D006801:Humans; D008099:Liver / Q000098:blood supply; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods* / Q000502:physiology; D019520:Living Donors; D012189:Retrospective Studies; D015607:Stents; D014682:Vena Cava, Inferior