title: [Genetic variability of Bordetella pertussis strains. Part II. Perspectives].
abstract: In some highly immunized countries with long history of pertussis vaccination (The Netherlands, Finland, Poland, USA, France, Great Britain) differences in the DNA patterns and ptxS1 and prn alleles present in B. pertussis strains used for production of pertussis component in the DTP vaccine, in comparison to strains presently isolated from clinical materials have been found. Studies on efficacy of whole-cell and acellular pertussis vaccines in elimination of B. pertussis strains harbouring different gene variants in a particular country might indicate a need for a change of B. pertussis strains used for production of the vaccine against pertussis.
authors.affiliation: Zakład Badania Surowic i Szczepionek Państwowego Zakładu Higieny ul. Chocimska 24, 00-791 Warszawa. agzyl@pzh.gov.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Gzyl
authors.forename: Ewa
authors.initials: E
authors.lastname: Augustynowicz
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Gniadek
authors.forename: Janusz
authors.initials: J
authors.lastname: Slusarczyk
mesh_terms: D000483:Alleles; D001886:Bordetella pertussis / Q000235:genetics*; D004269:DNA, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000235:genetics*; D005060:Europe; D014644:Genetic Variation; D006801:Humans; D037342:Pertussis Toxin; D014481:United States; D014917:Whooping Cough / Q000517:prevention & control*
chemical_list: D004269:DNA, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D037342:Pertussis Toxin