title: [Expression of EP-CAM, beta-catenin in the carcinogenesis of squamous cell carcinoma of uterine cervix].
abstract: OBJECTIVE
  To study the expression of EP-CAM, beta-catenin in the carcinogenesis of squamous cell carcinoma of uterine cervix.
  
  
  METHODS
  The expressions of EP-CAM and beta-catenin were detected with immunohistochemical stain in 14 cases of normal cervical squamous epithelium, 32 cases of cervical intraepithelial neoplasia (CIN) and 38 cases of cervical invasive squamous cell carcinoma.
  
  
  RESULTS
  The over-expression rates of EP-CAM were 0, 7.1%, 20.0%, 62.5% and 55.3% for normal cervical epithelium, CINI, CINII, CINIII and carcinoma groups. The EP-CAM over-expression rates in CINIII and cervical carcinoma groups were significantly higher than those in normal epithelium and CINI groups (P < 0.001). No aberrant expression of beta-catenin was shown in normal cervical epithelium, while the aberrant expression rates of beta-catenin in CINI, CINII, CINIII and cervical carcinoma group were 28.6%, 40.0%, 62.5% and 84.2%. The aberrant expression rate of beta-catenin increased with the increase in degree of CIN and development of cervical carcinoma. The over-expression rate of EP-CAM was reversely related to the differentiation of cervical squamous cell carcinoma (P < 0.001).
  
  
  CONCLUSIONS
  EP-CAM and beta-catenin may be involved in the carcinogenesis of squamous cell carcinoma of uterine cervix. The over-expression of EP-CAM and aberrant expression of beta-catenin may serve as markers of squamous carcinogenesis of uterine cervix.
authors.affiliation: Laboratory of Experimental Pathology, Hebei Medical University, Shijiazhuang 050017, China.
authors.forename: Jian-zhu
authors.initials: JZ
authors.lastname: Yang
authors.forename: Xiang-hong
authors.initials: XH
authors.lastname: Zhang
authors.forename: Wen-xin
authors.initials: WX
authors.lastname: Wu
authors.forename: Xia
authors.initials: X
authors.lastname: Yan
authors.forename: Yan-li
authors.initials: YL
authors.lastname: Liu
authors.forename: Jun-ling
authors.initials: JL
authors.lastname: Wang
authors.forename: Feng-rong
authors.initials: FR
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor; D015820:Cadherins / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002584:Cervix Uteri / Q000166:cytology / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D018450:Disease Progression; D004847:Epithelial Cells / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006801:Humans; D015534:Trans-Activators / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*; D051176:beta Catenin; D002578:Uterine Cervical Dysplasia / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C495270:CTNNB1 protein, human; D015820:Cadherins; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051176:beta Catenin