[Correlation between integrin alpha5beta1 expression in colorectal carcinomas and the biological behavior of the carcinoma cells].
OBJECTIVE
To study the correlation between the expression of integrin alpha5beta1 in colorectal carcinomas and the differentiation and metastasis of the tumor cells.


METHODS
The expression levels of integrin alpha5beta1 were detected immunohistochemically in 81 pairs of cancerous and non-cancerous tissues of patients with colorectal cancer.


RESULTS
The expression of integrin alpha5beta1 was significantly higher in the samples of colorectal carcinomas, than in non-cancerous tissues (P<0.05). Lower expression levels were detected in moderately or well differentiated colorectal carcinomas than in poorly differentiated ones (P<0.05). No significant relation was noted between the expression of integrin alpha5beta1 and lymph node metastasis of the colorectal carcinomas (P>0.05).


CONCLUSIONS
Alpha5beta1 expression is significantly associated with the carcinogenesis and differentiation of colorectal carcinomas, but not with their lymph node metastasis, and the expression level might be used as a valuable pathological indicator for the carcinogenesis and progression of colorectal carcinomas.
Zhou
Jun
J
Department of Pathology, First Military Medical University, Guangzhou 510515, China.
Ding
Yan-qing
YQ
Yang
Hong-jun
HJ
Zhang
Jin-hua
JH
Chen
Ai-bao
AB
D002455:Cell Division; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D039081:Integrin alpha5beta1 / Q000032:analysis* / Q000502:physiology; D009362:Neoplasm Metastasis
D039081:Integrin alpha5beta1