Chemical and functional diversity of small molecule ligands for RNA.
Functional RNAs such as ribosomal RNA and structured domains of mRNA are targets for small molecule ligands that can act as modulators of the RNA biological activity. Natural ligands for RNA display a bewildering structural and chemical complexity that has yet to be matched by synthetic RNA binders. Comparison of natural and artificial ligands for RNA may help to direct future approaches to design and synthesize potent novel scaffolds for specific recognition of RNA targets.
Hermann
Thomas
T
Department of Computational Chemistry & Structure, Anadys Parmaceuticals, Inc., 9050 Camino Santa Fe, San Diego, CA 92121, USA. thermann@anadyspharma.com
D020121:5' Untranslated Regions; D001665:Binding Sites; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D008024:Ligands; D008956:Models, Chemical; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D012333:RNA, Messenger / Q000378:metabolism; D012335:RNA, Ribosomal; D016601:RNA-Binding Proteins; D012270:Ribosomes / Q000737:chemistry; D014815:Vitamins / Q000737:chemistry
D020121:5' Untranslated Regions; D008024:Ligands; D012333:RNA, Messenger; D012335:RNA, Ribosomal; D016601:RNA-Binding Proteins; D014815:Vitamins; D012313:RNA