title: Interobserver reproducibility of ulceration assessment in primary cutaneous melanomas.
abstract: In the recently revised melanoma staging system proposed by the American Joint Committee on Cancer (AJCC), ulceration assessment by the pathologist is a pivotal parameter. Patients upstaged because of ulceration might be included in adjuvant trials conducted in AJCC stage II melanoma patients. Therefore, accuracy based on interobserver reproducibility for melanoma ulceration assessment is crucial for proper clinical management. In some cases, it is extremely difficult, even for an experienced pathologist, to distinguish between trauma-induced ulceration, artifact and tumoral ulceration. Whether this difficulty may be resolved by the use of a more precise definition of ulceration has not been evaluated. Therefore, we have proposed a refined definition of melanoma ulceration and we tested whether this definition might improve the interobserver interpretative reproducibility of ulceration in primary cutaneous melanomas. The results of this study support the need for a more precise definition of melanoma ulceration that rules out biopsy trauma or processing artifact and could be incorporated into a standardised pathology worksheet for reporting primary melanomas.
authors.affiliation: Institut Gustave-Roussy, Villejuif, France. spatz@igr.fr
authors.forename: A
authors.initials: A
authors.lastname: Spatz
authors.forename: M G
authors.initials: MG
authors.lastname: Cook
authors.forename: D E
authors.initials: DE
authors.lastname: Elder
authors.forename: M
authors.initials: M
authors.lastname: Piepkorn
authors.forename: D J
authors.initials: DJ
authors.lastname: Ruiter
authors.forename: R L
authors.initials: RL
authors.lastname: Barnhill
mesh_terms: D001706:Biopsy / Q000379:methods; D006801:Humans; D008545:Melanoma / Q000473:pathology*; D015588:Observer Variation; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000473:pathology*; D012883:Skin Ulcer / Q000473:pathology*