title: Role of post-operative topical corticosteroids in recurrence rate after pterygium excision with conjunctival autograft.
abstract: BACKGROUND
  Recurrence of pterygium is the most common failure of the pterygium operation. The use of conjunctival autograft after pterygium excision has shown a low recurrence rate. However, it has a board range of variations regarding the recurrence rates, which may be influenced by many factors. From the authors' clinical observation, it was found that the recurrence rate was higher in patients who received inadequate post-operative topical corticosteroid treatment.
  
  
  OBJECTIVE
  To study the association between adequacy of post-operative topical corticosteroids and recurrence rate in patients with primary pterygium who underwent excision with conjunctival autograft.
  
  
  METHODS
  Retrospective, case-control study.
  
  
  METHODS
  A total of 142 eyes of 137 patients with primary pterygium who underwent excision with conjunctival autograft between January 1996 and June 2002 were enrolled in this study. These patients were evaluated for recurrence of their pterygia and adequacy of post-operative topical corticosteroids by chart review, re-examination, self-reported questionnaire, and interview. Cases were patients with recurrent pterygium. Controls were from patients without recurrence.
  
  
  RESULTS
  There were 21 recurrences (14.8%) of a total of 142 eyes treated. Five of the 21 recurrences occurred in good compliant patients with adequate post-operative topical corticosteroid therapy. Sixteen recurrences occurred in patients with inadequate post-operative topical corticosteroids. In this group, 6 cases missed their follow-up schedules, 3 cases were lost to follow-up after 1.5-2 months, 1 case had poor compliance with treatment, and 6 cases were steroid responders then the treatment was discontinued or changed to a weaker preparation. The study demonstrates significant association between the adequacy of post-operative topical corticosteroid and pterygium recurrence rate. The odds ratio was 190.4 (95% CI, 36.61-951.84).
  
  
  CONCLUSIONS
  A high recurrence rate was found in patients who received inadequate post-operative topical corticosteroid. However, the recurrence rate was much lower from 14.8 per cent to 4 per cent when the patients with inadequate corticosteroid therapy were excluded. The study provides evidence that post-operative topical corticosteroids appear to play a role in reducing the pterygium recurrence rate.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Sudarat
authors.initials: S
authors.lastname: Yaisawang
authors.forename: Pittaya
authors.initials: P
authors.lastname: Piyapattanakorn
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003228:Conjunctiva / Q000637:transplantation*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011625:Pterygium / Q000188:drug therapy / Q000517:prevention & control* / Q000601:surgery*; D012189:Retrospective Studies; D055502:Secondary Prevention
chemical_list: D000305:Adrenal Cortex Hormones