Contributions of vesicular stomatitis virus to the understanding of RNA virus evolution.
Vesicular stomatitis virus has been a preferred system to study evolution for several decades. New approaches to antiviral treatment, such as lethal mutagenesis, stem from investigations done with VSV. Recent work has shed new light in the way we view neutrality, a fundamental concept to understand the evolutionary history of RNA viruses.
Novella
Isabel S
IS
Department of Microbiology and Immunology, Medical College of Ohio, 3055 Arlington Ave., Toledo 43614, OH, USA. isabel@mco.edu
D000818:Animals; D005075:Biological Evolution; D006801:Humans; D009154:Mutation; D018353:Rhabdoviridae Infections / Q000821:virology*; D014721:Vesicular stomatitis Indiana virus / Q000145:classification / Q000235:genetics*