Messenger RNA reprogramming by spliceosome-mediated RNA trans-splicing.
In the human genome, the majority of protein-encoding genes are interrupted by introns, which are removed from primary transcripts by a macromolecular enzyme known as the spliceosome. Spliceosomes can constitutively remove all the introns in a primary transcript to yield a fully spliced mRNA or alternatively splice primary transcripts leading to the production of many different mRNAs from one gene. This review examines how spliceosomes can recombine two primary transcripts in trans to reprogram messenger RNAs.
Garcia-Blanco
Mariano A
MA
Department of Molecular Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA. garci001@mc.duke.edu
D017398:Alternative Splicing; D000818:Animals; D001483:Base Sequence; D005091:Exons; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009154:Mutation; D012326:RNA Splicing; D012333:RNA, Messenger / Q000378:metabolism / Q000502:physiology*; D017381:Spliceosomes / Q000378:metabolism*
D012333:RNA, Messenger