[In vivo Terbinafine inefficacy on cutaneous leishmaniasis caused by Leishmania (Leishmania) amazonensis in C57BL/6 mice].
The efficiency of terbinafine was tested in C57BL/6 mice inoculated with the Leishmania (Leishmania) amazonensis strain MHOM/BR/PH8. The mice were administered: terbinafine at a dose of 100mg/kg/d by via oral; 0.9% saline solution orally as the control; and subcutaneous sodium stibogluconate 400mg SbV/kg/d as gold standard, for 20 days. Terbinafine was demonstrated to be ineffective when compared to the controls, using clinical and parasitological parameters and the limiting dilution assay.
Sampaio
Raimunda Nonata Ribeiro
RN
Laboratório de Dermatomicologia, Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brasil. mrsampaio@hotmail.com
Takano
Gustavo Henrique Soares
GH
Malacarne
Ana Cristina Barbieri
AC
Pereira
Tércio Rodrigues
TR
de Magalhães
Albino Verçosa
AV
D000818:Animals; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009281:Naphthalenes / Q000627:therapeutic use*; D000077291:Terbinafine
D000981:Antiprotozoal Agents; D004791:Enzyme Inhibitors; D009281:Naphthalenes; D000077291:Terbinafine; D000967:Antimony Sodium Gluconate