Quantitative structure-activity relationships for predicting skin and respiratory sensitization.
Quantitative structure-activity relationships (QSARs) for predicting skin and respiratory sensitization are reviewed. Overall, progress has been hampered by the sparseness of good quality experimental data, a fact that makes it difficult, at this time, to recommend one or two QSARs for predicting skin and respiratory sensitization. Creation of appropriate data sets for uninvestigated classes of chemicals by experimentation should facilitate the development of more robust QSARs for predicting skin and respiratory sensitization. Such QSARs will be valuable in the evaluation of identifiable toxic hazards where dose responses are relevant, as is the case for skin and respiratory sensitization.
Rodford
Rosemary
R
Solo Star, 19 Spinney Road, Chawston, Bedford, Bedfordshire MK44 3BW, United Kingdom.
Patlewicz
Grace
G
Walker
John D
JD
Payne
Martin P
MP
D000279:Administration, Cutaneous; D000818:Animals; D001681:Biological Assay; D004785:Environmental Pollutants / Q000276:immunology* / Q000633:toxicity*; D005544:Forecasting; D006801:Humans; D007114:Immunization; D019570:Inhalation Exposure; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008962:Models, Theoretical; D021281:Quantitative Structure-Activity Relationship; D012882:Skin Tests
D004785:Environmental Pollutants