title: A long-range chiral relay via tertiary amide group in asymmetric catalysis: new amino acid-derived N,P-ligands for copper-catalysed conjugate addition.
abstract: New N,P-ligands 4-6, derived from valinol and prolinol, respectively, have been developed for the asymmetric, copper(I)-catalysed conjugate addition of diethylzinc to unsaturated ketones; the tertiary amide group has been shown to effectively relay the chiral information from the ligand backbone to the active centre.
authors.affiliation: Department of Chemistry, University of Glasgow, Glasgow, UK G12 8QQ. amalkov@chem.gla.ac.uk
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Malkov
authors.forename: John B
authors.initials: JB
authors.lastname: Hand
authors.forename: Pavel
authors.initials: P
authors.lastname: Kocovský
mesh_terms: D000577:Amides / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D003300:Copper / Q000737:chemistry*; D008024:Ligands; D008956:Models, Chemical; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry; D013237:Stereoisomerism; D014633:Valine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000577:Amides; D000596:Amino Acids; D008024:Ligands; D009942:Organometallic Compounds; D011759:Pyrrolidines; C040994:valinol; C010509:prolinol; D003300:Copper; D014633:Valine