Quorum sensing by the Lyme disease spirochete.
The Lyme disease spirochete, Borrelia burgdorferi, utilizes a LuxS/autoinducer-2-dependent quorum sensing mechanism to control a specific subset of bacterial proteins. It is hypothesized that this system facilitates transmission of B. burgdorferi from feeding ticks into warm-blooded hosts.
Stevenson
Brian
B
Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, MS 415 Chandler Medical Center, Lexington, KY 40536-0298, USA. bstev0@uky.edu
von Lackum
Kate
K
Wattier
Rachel L
RL
McAlister
Jason D
JD
Miller
Jennifer C
JC
Babb
Kelly
K
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D025065:Borrelia burgdorferi / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D013437:Carbon-Sulfur Lyases; D006801:Humans; D008193:Lyme Disease / Q000382:microbiology / Q000635:transmission*
D001426:Bacterial Proteins; D013437:Carbon-Sulfur Lyases; C117753:LuxS protein, Bacteria