Signaling via Toll-like receptor 5 can initiate inflammatory mediator production by murine osteoblasts.
Murine osteoblasts express Toll-like receptor 5 (TLR5), and this expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Importantly, flagellin activates transcriptional regulators and elicits proinflammatory cytokine production, suggesting TLR5 functionality. TLR5 may represent an important mechanism underlying the recognition of bacterial pathogens by osteoblasts during bone infections.
Madrazo
Denise R
DR
Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA.
Tranguch
Susanne L
SL
Marriott
Ian
I
D000818:Animals; D001483:Base Sequence; D001850:Bone Diseases, Infectious / Q000209:etiology / Q000276:immunology / Q000382:microbiology; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis; D004247:DNA / Q000235:genetics; D005408:Flagellin / Q000276:immunology / Q000494:pharmacology; D018836:Inflammation Mediators / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D010006:Osteoblasts / Q000276:immunology* / Q000502:physiology; D011550:Pseudomonas aeruginosa / Q000276:immunology / Q000472:pathogenicity; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology*; D012475:Salmonella / Q000276:immunology / Q000472:pathogenicity; D015398:Signal Transduction; D013211:Staphylococcus aureus / Q000276:immunology / Q000472:pathogenicity; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors; D015854:Up-Regulation / Q000187:drug effects
D016207:Cytokines; D018836:Inflammation Mediators; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors; D005408:Flagellin; D004247:DNA