title: [Experience in combined topiramate therapy of drug-resistant epilepsy].
abstract: Efficacy of topiramate usage in combined therapy of 35 patients (25 adults and 10 children) with therapy resistant epilepsy was analyzed. In 11.4% of the cases, medication remission for a period of up to 3 months has been achieved. Therapeutic efficacy, with reducing the number of fits by half was achieved in 40% of the cases. In children topiramate therapy was less beneficial. The authors emphasize a good tolerability of topiramate, along with a first ever described side-effect, emerging as a spot pigmentation. The results obtained reveal effectiveness of topiramate using in epileptology, in particular, in drug-resistant epilepsy.
authors.forename: V A
authors.initials: VA
authors.lastname: Karlov
authors.forename: P N
authors.initials: PN
authors.lastname: Vlasov
authors.forename: N V
authors.initials: NV
authors.lastname: Freĭdkova
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D004828:Epilepsies, Partial / Q000188:drug therapy*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010859:Pigmentation Disorders / Q000139:chemically induced; D000077236:Topiramate; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose