Hemophagocytic syndrome associated with Kikuchi's disease.
A 13-yr-old female was admitted to our hospital with fever, seizure, and cervical lymphadenopathy. Laboratory data showed pancytopenia, elevation of serum transaminase, lactate dehydrogenase, triglyceride, and ferritin levels. Lymph node biopsy revealed features of Kikuchi's disease and there were signs of histiocytosis and hemophagocytic phenomenon in bone marrow. She recovered after treatment with intravenous immunoglobulin and corticosteroids therapy. Hemophagocytic syndrome can be associated with Kikuchi's disease especially in childhood and seems to have a less aggressive clinical course and better prognosis.
Kim
Young Mi
YM
Department of Pediatrics, College of Medicine, Pusan National University, Busan, Korea.
Lee
Yoon Jin
YJ
Nam
Sang Ook
SO
Park
Su Eun
SE
Kim
Ji Yoen
JY
Lee
Eun Yup
EY
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001706:Biopsy; D001854:Bone Marrow Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D005293:Ferritins / Q000097:blood; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications* / Q000175:diagnosis*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism / Q000627:therapeutic use; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000175:diagnosis; D009336:Necrosis; D010198:Pancytopenia / Q000175:diagnosis; D011379:Prognosis; D000637:Transaminases / Q000097:blood; D014280:Triglycerides / Q000097:blood
D000305:Adrenal Cortex Hormones; D007136:Immunoglobulins; D014280:Triglycerides; D005293:Ferritins; D007770:L-Lactate Dehydrogenase; D000637:Transaminases