T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura.
Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.
Olsson
Bob
B
Research Center for Endocrinology and Metabolism, Sahlgrenska University Hospital, Göteborg University, SE-413 45 Göteborg, Sweden.
Andersson
Per-Ola
PO
Jernås
Margareta
M
Jacobsson
Stefan
S
Carlsson
Björn
B
Carlsson
Lena M S
LM
Wadenvik
Hans
H
D001792:Blood Platelets / Q000276:immunology* / Q000502:physiology; D016022:Case-Control Studies; D003602:Cytotoxicity, Immunologic / Q000235:genetics*; D053804:Granzymes; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics; D008562:Membrane Glycoproteins / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000235:genetics* / Q000276:immunology*; D011971:Receptors, Immunologic / Q000235:genetics; D015375:Receptors, Interleukin-2 / Q000235:genetics; D054340:Receptors, KIR; D012697:Serine Endopeptidases / Q000235:genetics; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000502:physiology
D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D054340:Receptors, KIR; D054353:Perforin; D007371:Interferon-gamma; C509213:GZMB protein, human; D053804:Granzymes; D012697:Serine Endopeptidases