Study of stereoselective synthesis of (+/-)-neocnidilide.
Neocnidilide 1, isolated from Apium graveleues L (Umbelliferae), has shown activity to inhibit the growth of mycotoxin-producing fungi. An efficient method for the synthesis of the racemic neocnidilide by the stereoselective reaction of hemiacetal 6 with n-BuMgBr has been developed.
Jiao
Xiao-Zhen
XZ
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Xie
Ping
P
Zu
Lian-Suo
LS
Liang
Xiao-Tian
XT
D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D004365:Drugs, Chinese Herbal; D008968:Molecular Conformation
D001572:Benzofurans; D004365:Drugs, Chinese Herbal; C087913:neocnidilide