Are biosensor arrays in one membrane possible? A combination of multifrequency impedance measurements and chemometrics.
A novel concept of a membrane-based micro-array biosensor is presented. The methodology is based on a single lipid membrane interrogated with electrochemical impedance techniques followed by multivariate data analysis. A single membrane is designed so that relaxation processes with a range of time constants can be probed at different potentials. A range of other approaches cited in the literature is reviewed.
Lindholm-Sethson
Britta
B
Department of Chemistry: Biophysical Chemistry, Umeå University, 901 87, Umeå, Sweden. britta.sethson@chem.umu.se
Nyström
Josefina
J
Geladi
Paul
P
Koeppe
Roger
R
Nelson
Andrew
A
Whitehouse
Conor
C
D015374:Biosensing Techniques / Q000379:methods*; D004563:Electrochemistry; D006096:Gramicidin / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D008564:Membrane Potentials; D008670:Metals / Q000737:chemistry; D015999:Multivariate Analysis
D008051:Lipid Bilayers; D008670:Metals; D006096:Gramicidin