title: First examples of improved catalytic asymmetric C-C bond formation using the monodentate ligand combination approach.
abstract: [reaction: see text] Using a combination of chiral monodentate phosphoramidite ligands in the rhodium-catalyzed conjugate addition of boronic acids to three different substrates, we have shown for the first time that the ligand combination approach is applicable for C-C bond formation. Chiral catalysts based on hetero-combinations of ligands are found to be more effective than the homo-combinations. (31)P NMR experiments show that the hetero-combinations are formed in excess over the homo-combinations.
authors.affiliation: Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Ate
authors.initials: A
authors.lastname: Duursma
authors.forename: Rob
authors.initials: R
authors.lastname: Hoen
authors.forename: Julia
authors.initials: J
authors.lastname: Schuppan
authors.forename: Ron
authors.initials: R
authors.lastname: Hulst
authors.forename: Adriaan J
authors.initials: AJ
authors.lastname: Minnaard
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa