D-xylose absorption in non-chronic diarrhea AIDS patients with the wasting syndrome.
OBJECTIVE
To compare the intestinal absorptive capacity, permeability function and duodenal histopathology in human immunodeficiency virus (HIV) patients with or without wasting syndrome who had not suffered from chronic diarrhea.


METHODS
Adult HIV patients who attended Chulalongkorn Hospital were included. The subjects were classified into wasting and non-wasting groups (group I and group II). 25 g oral D-xylose test, oral phenolsulfonephthalein test and duodenal histopathology were performed.


RESULTS
Of thirty-two HIV patients, aged between 25-50 years enrolled, there were 18 and 14 patients in group I and group II, respectively. In both groups, the baseline data, permeability function and histopathology were similar. Intestinal absorptive capacity was statistically different, i.e. 5-hour urine D-xylose was 3.96 +/- 2.81 g and 5.95 +/- 2.47 g in group I and group II respectively (p < 0.05).


CONCLUSIONS
This study demonstrated that D-xylose absorption was decreased in non-diarrheal, wasting HIV infected patients. Abnormal absorptive capacity is a common phenomenon found in HIV patients with wasting syndrome as determined by standard 25 g oral D-xylose test.
Luangjaru
Somchai
S
Department of Medicine, Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima 30000, Thailand.
Ruxrungtham
Kait
K
Wisedopas
Narumon
N
Mahachai
Varocha
V
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000503:physiopathology*; D000328:Adult; D002908:Chronic Disease; D003967:Diarrhea / Q000209:etiology* / Q000503:physiopathology*; D005260:Female; D019247:HIV Wasting Syndrome / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D014994:Xylose / Q000493:pharmacokinetics*
D014994:Xylose