Variation in gene expression patterns in human gastric cancers.
Gastric cancer is the world's second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing approximately 30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.
Chen
Xin
X
Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA.
Leung
Suet Y
SY
Yuen
Siu T
ST
Chu
Kent-Man
KM
Ji
Jiafu
J
Li
Rui
R
Chan
Annie S Y
AS
Law
Simon
S
Troyanskaya
Olga G
OG
Wong
John
J
So
Samuel
S
Botstein
David
D
Brown
Patrick O
PO
D000230:Adenocarcinoma / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D005753:Gastric Mucosa / Q000378:metabolism; D020869:Gene Expression Profiling; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D013274:Stomach Neoplasms / Q000209:etiology / Q000235:genetics* / Q000378:metabolism