Activity of daptomycin against recent North American isolates of Streptococcus pneumoniae.
Daptomycin MICs at which 50% of isolates were inhibited (MIC(50)s) and MIC(90)s determined by the NCCLS broth microdilution method were both 0.25 microg/ml (range, 0.06 to 2 microg/ml) for 350 pneumococcal isolates. MICs determined by E test strips on commercially prepared Mueller-Hinton sheep blood agars with different calcium contents were 2 to 3 dilutions higher than those determined by strips that contained daptomycin plus calcium. Daptomycin zone diameters varied little on the same media.
Restrepo
M I
MI
Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA.
Velez
J A
JA
McElmeel
M L
ML
Whitney
C G
CG
Jorgensen
J H
JH
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D003470:Culture Media; D017576:Daptomycin / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009656:North America; D011008:Pneumococcal Infections / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D017576:Daptomycin; D002118:Calcium