[Protein kinase CK2: an enzyme that likes to be different].
Protein kinase CK2 (formerly known as casein kinase 2) was among the first protein kinases to be identified and characterized. Surprisingly, in spite of intense efforts, the regulation and cellular functions of CK2 remain obscure. However, recent data on its molecular structure, its signal-mediated intracellular dynamic localization and its unexpected function in cell survival have raised new interest in this enzyme. These studies reveal unique features of CK2 and highlight its importance in the transduction of survival signals.
Buchou
Thierry
T
Inserm EMI 104, Département Réponse et Dynamique Cellulaire, CEA Grenoble, 38054 Grenoble Cedex 9, France.
Cochet
Claude
C
D017209:Apoptosis; D047390:Casein Kinase II; D002455:Cell Division; D002470:Cell Survival / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D004268:DNA-Binding Proteins; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology; D017346:Protein Serine-Threonine Kinases / Q000494:pharmacology*; D015398:Signal Transduction
D004268:DNA-Binding Proteins; D047390:Casein Kinase II; D017346:Protein Serine-Threonine Kinases