Antidepressant properties of antibodies to serotonin, brain-specific S100 protein, and delta sleep-inducing peptide.
Potentiated antibodies to delta sleep-inducing peptide and S100 protein produced an antidepressant effect in Wistar rats. This effect was more pronounced after combined treatment with these antibodies. It can be assumed that these antibodies modulate neurobiological mechanisms of positive emotional reinforcement and, therefore, affect the resistance to depression associated with psychoemotional stress.
Meshcheryakov
A F
AF
Department of Emotions and Emotional Stress, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.
D000639:Amitriptyline / Q000037:antagonists & inhibitors / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D003701:Delta Sleep-Inducing Peptide / Q000037:antagonists & inhibitors* / Q000276:immunology; D008297:Male; D051381:Rats; D009418:S100 Proteins / Q000037:antagonists & inhibitors* / Q000276:immunology; D012701:Serotonin / Q000276:immunology*
D000906:Antibodies; D000928:Antidepressive Agents; D009418:S100 Proteins; D000639:Amitriptyline; D012701:Serotonin; D003701:Delta Sleep-Inducing Peptide