Anxiety and high plasma catecholamines do not impair pharmaco-induced erection of psychogenic erectile dysfunctional patients.
The aim of this study was to assess the influence of anxiety and plasma catecholamines on the pharmaco-induced erection of psychogenic erectile dysfunction (ED) patients. A total of 23 patients with psychogenic ED aged from 19 to 43 y were submitted to: (1) anxiety evaluation by the Spielberger's State and Trait Anxiety Inventory-STAI; (2) intracavernous injection of PGE1 10 microg+phentolamine 1 mg with the response monitored by Rigiscan; (3) blood sampling from cavernous bodies and cubital vein for adrenaline and noradrenaline levels determination by high performance liquid chromatography. The whole procedure was done in a single clinical setting at the same day. We found no significant correlation between the erection rigidity and the cavernous or peripheral catecholamines or between erection rigidity and anxiety scores. Some patients showed rigid erections despite high anxiety scores or penile catecholamine levels while others, with incomplete erections, had much smaller levels. These results are suggestive of a more complex mechanism controlling the penile sympathetic responsiveness in psychogenic ED patients.
Pagani
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São Paulo University Heart Institute and H.Ellis Institute, São Paulo, Brazil. edrdpag@aol.com
Glina
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Puech-Leão
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Strunz
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CM
Chao
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Timo-Iaria
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D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage; D001007:Anxiety; D004338:Drug Combinations; D004837:Epinephrine / Q000097:blood*; D007172:Erectile Dysfunction / Q000097:blood* / Q000503:physiopathology / Q000523:psychology*; D006801:Humans; D007267:Injections; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D010410:Penile Erection / Q000187:drug effects; D010646:Phentolamine / Q000008:administration & dosage; D020018:Sexual Dysfunctions, Psychological / Q000097:blood* / Q000503:physiopathology / Q000523:psychology*; D014665:Vasodilator Agents / Q000008:administration & dosage
D000317:Adrenergic alpha-Antagonists; D004338:Drug Combinations; D014665:Vasodilator Agents; D000527:Alprostadil; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine