title: Sonotherapy, antirestenotic therapeutic ultrasound in coronary arteries: the first clinical experience.
abstract: We studied the safety and feasibility of intracoronary sonotherapy (IST) and its effect on the coronary vessel at 6 months. Thirty-seven patients with stable or unstable angina were included (40 lesions). The indication was de novo lesion (n = 26), restenosis (n = 2), in-stent restenosis (n = 11), and a total occlusion of a venous bypass graft. After successful angioplasty, IST was performed using a 5 Fr catheter with three serial ultrasound transducers operating at 1 MHz. IST was successfully performed in 36 lesions (success rate, 90%). IST exposure time per lesion was 718 +/- 127 sec. During hospital stay, one patient died due to a bleeding complication. At 6-month follow-up, one patient experienced acute myocardial infarction, eight patients underwent repeat PTCA. No patient underwent CABG. Late lumen loss was 1.05 +/- 0.70 mm with a restenosis rate of 25%. IVUS analysis revealed a neointima burden of 25% +/- 11%. IST can be applied safely and with high acute procedural success. Sonotherapy-related major adverse events were not observed. Late lumen loss and neointimal growth were similar to conventional PTCA approaches. These results justify the initiation of randomized clinical efficacy studies.
authors.affiliation: Department of Cardiology, Thoraxcentre, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Regar
authors.forename: A
authors.initials: A
authors.lastname: Thury
authors.forename: W J
authors.initials: WJ
authors.lastname: van der Giessen
authors.forename: G
authors.initials: G
authors.lastname: Sianos
authors.forename: J
authors.initials: J
authors.lastname: Vos
authors.forename: P C
authors.initials: PC
authors.lastname: Smits
authors.forename: S G
authors.initials: SG
authors.lastname: Carlier
authors.forename: P
authors.initials: P
authors.lastname: de Feyter
authors.forename: D P
authors.initials: DP
authors.lastname: Foley
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D001158:Arteries / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D001807:Blood Vessel Prosthesis; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D004562:Electrocardiography; D004867:Equipment Design; D004869:Equipment Safety; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000627:therapeutic use; D012307:Risk Factors; D015607:Stents; D016896:Treatment Outcome; D014464:Ultrasonic Therapy; D018084:Ultrasonography, Interventional
chemical_list: D019039:Platelet Glycoprotein GPIIb-IIIa Complex