Association between HPV 16/18 infection and expression of P53 protein in laryngeal papillomas.
To understand the relationship between expression of P53 protein and HPV16/18 infection in laryngeal papillomas, PCR and immunohistochemical techniques were used to examine the paraffin-embedded tissue samples of laryngeal papillomas from 35 subjects. HPV 16/18-DNA was found in 24 cases of laryngeal papillomas (68.8%). Overexpression of P53 protein was detected in 19 cases (54.3%). Both HPV16/18-DNA and overexpression of P53 protein were demonstrated in 12 cases of laryngeal papillomas (34.3%). Our results suggest that HPV16/18 infection and P53 gene mutation are associated with pathogenesis of laryngeal papillomas. The relation between HPV infection and P53 mutation in tissues of laryngeal papillomas remains to be clarified.
Chu
H
H
Department of Otorhiolaryngology, Tongji Hospital, Tongji Medical University, Wuhan 430030.
Reyt
E
E
D052162:Human papillomavirus 16; D052161:Human papillomavirus 18; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000821:virology; D009154:Mutation; D010212:Papilloma / Q000235:genetics* / Q000821:virology; D030361:Papillomavirus Infections / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D016159:Tumor Suppressor Protein p53