Inhibitory circuits in sensory maps develop through excitation.
Inhibitory and excitatory connections are equal partners in determining neuronal response properties. Although the development and plasticity of excitatory networks have been heavily studied, little is known about how inhibitory circuits develop. In a recent study, Gunsoo Kim and Karl Kandler have shown that, as in the development of excitatory circuits, synapse elimination and strengthening are important processes for the development of well-organized inhibitory circuits.
Issa
Naoum P
NP
Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, 947 E. 58th Street MC 0926, Chicago, Illinois 60637, USA. nissa@drugs.bsd.uchicago.edu
D000818:Animals; D001933:Brain Stem / Q000254:growth & development; D002490:Central Nervous System / Q000254:growth & development*; D005998:Glycine / Q000378:metabolism; D009433:Neural Inhibition; D009434:Neural Pathways / Q000254:growth & development*; D009474:Neurons / Q000378:metabolism; D013569:Synapses / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005680:gamma-Aminobutyric Acid; D005998:Glycine