[Effects of AlCl3 on transient outward K+ current and delayed rectifier K(+) current in acutely isolated rat hippocampal CA1 neurons].
The effects of aluminum chloride (AlCl3) on the transient outward potassium and delayed rectifier K(+) current in hippocampal CA1 neurons of rats were studied by the whole-cell patch clamp technique. It was found that AlCl3 reduced the transient outward potassium current and delayed rectifier K(+) current in a dose-dependent manner. 1000 micromol/L AlCl3 resulted in change in voltage and slope of the half-activation and the half-inactivation of I(A) and I(K). These results imply that AlCl3 may damage potassium channel of the hippocampal CA1 neurons from rats and this may be related to the mechanism of the damage to the central nervous system by aluminum.
Meng
Zi-Qiang
ZQ
Department of Environmental Science and Toxicology, Shanxi University, Taiyuan 030006. zqmeng@sxu.edu.cn
Bai
Wei
W
D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000633:toxicity*; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology*; D002469:Cell Separation; D002712:Chlorides / Q000633:toxicity*; D051668:Delayed Rectifier Potassium Channels / Q000502:physiology*; D005260:Female; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D051672:Shal Potassium Channels / Q000502:physiology*
D017607:Aluminum Compounds; D002712:Chlorides; D051668:Delayed Rectifier Potassium Channels; D051672:Shal Potassium Channels; D000077410:Aluminum Chloride