Neurotrophin 3 and its receptor TrkC immunoreactivity in glucagon cells of buffalo pancreas.
Neurotrophin 3 (NT3), a member of the neurotrophin family, and its specific receptor tyrosine kinase C (TrkC) are involved in the differentiation, survival, and maintenance of many neuronal populations. Recently, NT3 and TrkC were also retained involved in the biology of non-neuronal tissues. In this study, we report the presence of NT3- and TrkC-immunoreactive cells in the endocrine pancreas of adult buffalos. They were usually distributed at the periphery of islets and showed intense immunoreactivity. By double immunohistochemical staining, NT3- and TrkC-IR resulted to be colocalized in glucagon immunoreactive cells. These findings suggest endocrine and/or autocrine roles of NT3 in pancreatic A cells.
Lucini
C
C
Dip Strutture, funzioni e tecnologie biologiche, Università di Napoli "Federico II", Italy. lucini@unina.it
Costagliola
C
C
Borzacchiello
G
G
Castaldo
L
L
D000367:Age Factors; D000818:Animals; D002020:Buffaloes / Q000033:anatomy & histology / Q000378:metabolism*; D005934:Glucagon / Q000032:analysis; D007150:Immunohistochemistry; D020933:Neurotrophin 3 / Q000032:analysis*; D010179:Pancreas / Q000737:chemistry* / Q000166:cytology; D020812:Receptor, trkC / Q000032:analysis*
D020933:Neurotrophin 3; D005934:Glucagon; D020812:Receptor, trkC