Adult stem cells and tissue repair.
Recently, adult stem cells originating from bone marrow or peripheral blood have been suggested to contribute to repair and genesis of cells specific for liver, cardiac and skeletal muscle, gut, and brain tissue. The mechanism involved has been termed transdifferentiation, although other explanations including cell fusion have been postulated. Using adult stem cells to generate or repair solid organ tissue obviates the immunologic, ethical, and teratogenic issues that accompany embryonic stem cells.
Körbling
M
M
Department of Blood and Marrow Transplantation, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 423, Houston, TX 77030, USA.
Estrov
Z
Z
Champlin
R
R
D000328:Adult; D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D006801:Humans; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods*