[Effect of calmodulin antagonists on the membrane potential and intracellular Ca2+ stores in endothelial cells].
The role of calmodulin in electrical and Ca2+ signalling in intact rat aortic endothelial cells has been investigated. Calmodulin antagonists released Ca2+ from acetylcholine-sensitive and insensitive intracellular Ca2+ stores activated Ca(2+)-activated K+ channels and hyperpolarized endothelial cells. These findings indicate that calmodulin is involved in the regulation of intracellular Ca2+ stores in endothelial cells and is an essential agent for maintaining them in the Ca(2+)-loaded state.
Marchenko
S M
SM
Bogomolets Institute of Physiology, NAS of Ukraine, Kyiv. smm@serv.biph.kiev.ua
D000818:Animals; D001011:Aorta / Q000166:cytology; D002118:Calcium / Q000378:metabolism*; D002147:Calmodulin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects*; D024681:Potassium Channels, Calcium-Activated / Q000187:drug effects* / Q000502:physiology; D051381:Rats
D002147:Calmodulin; D024681:Potassium Channels, Calcium-Activated; D002118:Calcium