Designing redox metalloproteins from bottom-up and top-down perspectives.
The design of redox-active metalloproteins has been approached from two different directions. The de novo design approach has recently reached an important stage, at which structural information on several different designed metalloproteins has been obtained. This new information highlights the real challenge of this approach. The alternative approach involving re-engineering of evolved proteins has also made significant advances recently.
Barker
Paul D
PD
University of Cambridge, Chemical Laboratory and Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW, UK. pxb@mrc-lmb.cam.ac.uk
D019295:Computational Biology; D019143:Evolution, Molecular; D008667:Metalloproteins / Q000737:chemistry* / Q000502:physiology; D010084:Oxidation-Reduction; D015202:Protein Engineering; D017434:Protein Structure, Tertiary
D008667:Metalloproteins