title: Desensitization of H2-like histamine receptors stimulating cyclic AMP formation in the chick cerebral cortex.
abstract: Histamine potently stimulates cyclic AMP formation in slices of the chick cerebral cortex. Pretreatment of the tissue slices with 10 microM histamine for 2-30 min led to a time-dependent attenuation (when compared with values observed in the control tissue) of the cyclic AMP response produced by subsequent re-stimulation with 1, 10 or 100 microM histamine. The observed histamine-induced desensitization appears to be specific and homologous as the increase in cyclic AMP formation evoked by both forskolin or pituitary adenylate cyclase-activating polypeptide (PACAP) in slices pretreated with 10 microM histamine for 15 min was unchanged. It is concluded that in the chick cerebral cortex, H2-like receptors linked to cyclic AMP-generating system undergo rapid homologous desensitization.
authors.affiliation: Department of Biogenic Amines, Polish Academy of Sciences, POB-225, PL 90-950 Lódź, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Sedkowska
authors.forename: Jolanta B
authors.initials: JB
authors.lastname: Zawilska
authors.forename: Jerzy Z
authors.initials: JZ
authors.lastname: Nowak
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D002645:Chickens; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000096:biosynthesis / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011970:Receptors, Histamine H2 / Q000378:metabolism* / Q000502:physiology; D013997:Time Factors
chemical_list: D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011970:Receptors, Histamine H2; D005576:Colforsin; D006632:Histamine; D000242:Cyclic AMP