[Experimental lung carcinoma induced by fungi and mycotoxins--a review].
Up to now, most of the etiological studies of lung cancer have been focused on air pollution, radiation and smoking, etc, whereas in the past decades, we had found that fungi and mycotoxins in foodstuff might play important roles in the carcinogenesis of lung cancer. Our preliminary work showed that the liquid in pickled vegetables consumed by residents of Taihang Mountain area in Hebei Province and corn flours inoculated with Aspergillus flavus, Aspergillus versicolor in which aflatoxin G1(AFG1) and Sterigmatocystin (ST) were detected, could induce lung adenocarcinoma in Kunming, LACA and NIH mice as well as Wistar rats. Further studies with AFG1 and ST confirmed that oral administration of the two mycotoxins could induce lung adenocarconma in NIH mice. The experimental lung carcinoma induction studies with fungi and mycotoxins in our lab are summarized in this review.
Zhang
Xianghong
X
Laboratory of Experimental Pathology, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China. Zhangxh@hebmu.edu.cn
Wang
Fengrong
F
Wang
Junling
J
Yan
Xia
X
Huang
Xianghua
X
Xie
Tongxin
T
Zhang
Zhendong
Z
D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D001230:Aspergillus / Q000472:pathogenicity*; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D051379:Mice; D051381:Rats; D013241:Sterigmatocystin / Q000633:toxicity*
D000348:Aflatoxins; D013241:Sterigmatocystin; C027955:aflatoxin G1