title: Large aneurysms of the ascending aorta and major coronary arteries in a patient with hereditary hemorrhagic telangiectasia.
abstract: We describe a 50-year-old man with a history of hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease) who presented with chest pain, atrial fibrillation, and congestive heart failure. Echocardiography revealed a large ascending aortic aneurysm accompanied by severe aortic regurgitation and giant coronary artery aneurysms involving the right, left main, left anterior descending, and circumflex coronary arteries. Coronary angiography clearly defined multiple aneurysms involving the aorta and coronary arteries. The patient underwent complex and successful surgical repair of the aneurysms. To our knowledge, this is the first reported case of extensive cardiac involvement in a patient with this uncommon genetic disorder.
authors.affiliation: Department of Medicine, Park Ridge Hospital, Rochester, NY, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Hsi
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Ryan
authors.forename: Steven O
authors.initials: SO
authors.lastname: Hellems
authors.forename: David C
authors.initials: DC
authors.lastname: Cheeran
authors.forename: Lucy A
authors.initials: LA
authors.lastname: Sheils
mesh_terms: D017545:Aortic Aneurysm, Thoracic / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D001281:Atrial Fibrillation / Q000209:etiology; D002637:Chest Pain / Q000209:etiology; D003323:Coronary Aneurysm / Q000150:complications / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D017023:Coronary Angiography; D004452:Echocardiography; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000150:complications*