title: Low levels of ventricular CSF orexin/hypocretin in advanced PD.
abstract: The origins of excessive daytime sleepiness in Parkinson disease (PD) are unclear. The authors hypothesize that orexin neurons, a recently identified wake promoting system, could contribute to its pathophysiology. They measured orexin-A/hypocretin-1 concentration in ventricular CSF in 19 parkinsonian patients and compared it with neurologic controls. Orexin levels were lower in patients and decreased with the severity of the disease. The authors suggest that orexin neurons contribute to daytime sleepiness in late stage PD.
authors.affiliation: Service de Physiologie-Explorations Fonctionnelles, Unité Inserm U421-Université Paris XII, Faculté de Médecine de Créteil, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France. xavier.drouot@hmn.ap-hop-paris.fr
authors.forename: X
authors.initials: X
authors.lastname: Drouot
authors.forename: S
authors.initials: S
authors.lastname: Moutereau
authors.forename: J P
authors.initials: JP
authors.lastname: Nguyen
authors.forename: J P
authors.initials: JP
authors.lastname: Lefaucheur
authors.forename: A
authors.initials: A
authors.lastname: Créange
authors.forename: P
authors.initials: P
authors.lastname: Remy
authors.forename: F
authors.initials: F
authors.lastname: Goldenberg
authors.forename: M P
authors.initials: MP
authors.lastname: d'Ortho
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use; D001143:Arousal / Q000502:physiology; D002352:Carrier Proteins / Q000134:cerebrospinal fluid; D002552:Cerebral Ventricles; D003131:Combined Modality Therapy; D006970:Disorders of Excessive Somnolence / Q000134:cerebrospinal fluid / Q000209:etiology*; D004599:Electric Stimulation Therapy; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D009479:Neuropeptides / Q000134:cerebrospinal fluid / Q000172:deficiency*; D000068797:Orexins; D010300:Parkinson Disease / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy / Q000628:therapy
chemical_list: D000978:Antiparkinson Agents; D002352:Carrier Proteins; C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins