Fly models of Huntington's disease.
Can Drosophila models be engineered that accurately reflect Huntington's disease (HD) and other neurological diseases and can they contribute to the search for treatments and cures? A number of publications seem to provide a resounding yes to that question. Here we seek to review some of the salient features of these models.
Marsh
J Lawrence
JL
Department of Developmental and Cell Biology, University of California, Irvine, CA 92697-2300, USA. jlmarsh@uci.edu
Pallos
Judit
J
Thompson
Leslie M
LM
D000818:Animals; D004195:Disease Models, Animal; D004330:Drosophila; D006801:Humans; D006816:Huntington Disease / Q000378:metabolism / Q000503:physiopathology*