The ion gating effect: using a change in flexibility to allow label free electrochemical detection of DNA hybridisation.
A label free electrochemical method of detecting DNA hybridisation is presented based on the change in flexibility between a single strand of DNA and a duplex causing an ion-gating effect where hybridisation opens up the electrode to access of ions.
Gooding
J Justin
JJ
School of Chemical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. justin.gooding@unsw.edu.au
Chou
Alison
A
Mearns
Freya J
FJ
Wong
Elicia Leh-See
EL
Jericho
Kellie L
KL
D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D004277:DNA, Single-Stranded / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D007477:Ions; D009693:Nucleic Acid Hybridization / Q000379:methods; D013997:Time Factors
D004277:DNA, Single-Stranded; D007477:Ions; D004247:DNA