title: A comparison of patients who developed venous leg ulceration before and after their 50th birthday.
abstract: BACKGROUND
  although chronic venous ulceration (CVU) is often viewed primarily as a disease of the elderly, recent epidemiological data suggest that a significant proportion of patients first develop CVU before middle age. Such patients may represent a distinct group in terms of aetiology, natural history, prognosis and therapeutic options.
  
  
  OBJECTIVE
  to compare patients who developed CVU before (Group 1) and after (Group 2) their 50th birthday.
  
  
  METHODS
  one hundred and eighteen consecutive patients with "pure" CVU underwent history and examination, measurement of ankle-brachial pressure index (ABPI) and duplex ultrasound examination of the affected limb. Pure venous ulcers were defined as those of >4 weeks duration in the presence of venous reflux (>0.5) and in association with an ankle: brachial pressure index of >0.8.
  
  
  RESULTS
  patients in Group 1 (n = 54, 46%) were more likely to be male (32/54 [59%] vs 14/64 [23%], p < 0.001 chi(2)), to have a higher median (interquartile [IQR]) body mass index (32 [27-39] vs 27 [23-34], p = 0.003, Mann-Whitney U [MWU]), to have a history of deep venous thrombosis (23/54 [43%] vs 16/64 [25%], p = 0.04 chi(2)) and of ipsilateral long bone fracture (13/54 [24%] vs 5/64 [8%], p = 0.01, chi(2)), to have previously undergone venous surgery (27/54 [50%] vs 19/64 [30%] a median (IQR) of 11.5 (6.5-19) and 10 (2-20) years earlier respectively, and to have worse disease in terms of the duration of present ulcer (12 (6-36) vs 8.5 [3-18] months, p = 0.035 MWU), the total duration of ulcer disease (216 [72-360] vs 48 [12-120] months, p < 0.001 MWU), and the number of episodes of ulceration (3 [2-7] vs 1 [1-3], p = 0.002 MWU). There was no significant difference between the two groups in the pattern and severity of venous reflux with 46/54 (85%) of Group 1 and 54/64 (84%) of Group 2 patients having surgically correctable superficial venous reflux.
  
  
  CONCLUSIONS
  patients who develop CVU before their 50th birthday appear to represent a distinct group in terms of aetiology, natural history and prognosis. The importance of thrombo-embolic prophylaxis in the prevention, and the detection and correction of superficial venous reflux in the treatment, of such ulcers is re-emphasised.
authors.affiliation: Vascular Surgery Unit, Royal Infirmary, Edinburgh, Scotland, UK.
authors.forename: R K
authors.initials: RK
authors.lastname: MacKenzie
authors.forename: D A
authors.initials: DA
authors.lastname: Brown
authors.forename: P L
authors.initials: PL
authors.lastname: Allan
authors.forename: A W
authors.initials: AW
authors.lastname: Bradbury
authors.forename: C V
authors.initials: CV
authors.lastname: Ruckley
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014647:Varicose Ulcer / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D020246:Venous Thrombosis / Q000150:complications