title: Effects of selected growth factors on porcine meniscus in chemically defined medium.
abstract: Some evidence shows that selected growth factors can increase proteoglycan synthesis and that fibrin clot aids in the repair of meniscal tears. A significant (P<.05) dose-dependent stimulation of proteoglycan synthesis was found with platelet-derived growth factor AB (PDGF-[AB]), transforming growth factor-beta1 and bone morphogenetic protein-7 (osteogenic protein-I). In separate experiments, a significant increase in cellularity was found in the deep and superficial aspects of the explants treated with PDGF-(AB) compared with those treated with basal medium alone. The current study provides data as to which growth factors might prove most useful in the maintenance and repair of menisci.
authors.affiliation: Department of Orthopedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21205-0882, USA.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Lietman
authors.forename: William
authors.initials: W
authors.lastname: Hobbs
authors.forename: Nozomu
authors.initials: N
authors.lastname: Inoue
authors.forename: A Hari
authors.initials: AH
authors.lastname: Reddi
mesh_terms: D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D016895:Culture Media, Serum-Free; D004305:Dose-Response Relationship, Drug; D008297:Male; D008592:Menisci, Tibial / Q000378:metabolism*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D011509:Proteoglycans / Q000096:biosynthesis*; D013552:Swine; D016212:Transforming Growth Factor beta / Q000494:pharmacology*; D053773:Transforming Growth Factor beta1
chemical_list: D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D016895:Culture Media, Serum-Free; D010982:Platelet-Derived Growth Factor; D011509:Proteoglycans; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1