Accumulation of interleukin-1 receptor antagonist in blood products and the effect of pre-storage leukocyte reduction.
Interleukin-1 receptor antagonist (IL-1 ra) is one of the anti-inflammatory cytokines and its concentration is reported to increase in a time-dependent manner in the blood products. We have checked the effects of pre-storage leukocyte reduction on the accumulation of IL-1 ra. Although IL-1 ra concentration exhibited a major increase in non-filtered blood, it remains quite stable in blood filtered before storage. As the increase in IL-1 ra may have an immunosuppressive effect on recipients, universal pre-storage leukocyte reduction appears to be advisable even for autologous blood donation.
Saigo
Katsuyasu
K
Hashimoto
Makoto
M
Yamamoto
Mitsuteru
M
Fujioka
Yoman
Y
Kumagai
Shunichi
S
D001781:Blood Component Removal / Q000379:methods; D001782:Blood Donors; D005374:Filtration; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000378:metabolism*; D007962:Leukocytes / Q000166:cytology / Q000378:metabolism*; D012795:Sialoglycoproteins / Q000378:metabolism*; D013997:Time Factors
C507763:IL1RN protein, human; D018836:Inflammation Mediators; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D012795:Sialoglycoproteins