title: Polymer/carrier composites as materials and reactors for organic synthesis.
abstract: In this work new polymer/carrier composites are described which serve as novel materials in flow-through reactors for polymer-supported organic solution-phase synthesis. Monolithic polymer/carrier columns are prepared by a new precipitation polymerization process inside the void pore volume of megaporous glass carrier materials. Chemical functionalization of the internal polymer phase with chlorosulfonic acid or trimethylamine generates small, interconnected ion-exchange resin beads with a diameter of 1-3 microm which can be used for a large variety of organic syntheses. These monolithic rods are incorporated into an appropriate casing and can conveniently be operated in the flow-through mode. Important successful applications are polymer-assisted solution-phase reductions, oxidations and Horner-Emmons olefinations. Additionally, the use of these monolithic columns as catalytic microreactors and their performance in selected reactions are described.
authors.affiliation: Institut für Chemische Verfahrenstechnik, Technische Universität Clausthal, Leibnizstrasse 17, D-38678 Clausthal-Zellerfeld, Germany. kunz@icvt.tu-clausthal.de
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kunz
authors.forename: Hagen
authors.initials: H
authors.lastname: Schönfeld
authors.forename: Andreas
authors.initials: A
authors.lastname: Kirschning
authors.forename: Wladimir
authors.initials: W
authors.lastname: Solodenko
mesh_terms: D002384:Catalysis; D009930:Organic Chemicals / Q000138:chemical synthesis*; D011108:Polymers / Q000737:chemistry*
chemical_list: D009930:Organic Chemicals; D011108:Polymers