[Synthesis and DNA binding studies of Ruthenium complexes by spectra].
New Complexes Ru(bpy)2dppx2+ were synthesized. The binding of Ru(bpy)2dppx2+ to calf thymus DNA has been investigated by using electronic absorption and fluorescence spectra. The intercalation mode was proved to exist. The DNA leads to a dramatic enhancement of the photoluminescence of the drug at 599 nm (lambda ex = 471 nm) and absorption hypochromic effect and red shift. It was obvious that Ruthenium complexes may be used at a good DNA probe.
Wu
M
M
Analysis and Testing Center, Hubei University, 430062 Wuhan.
Song
G
G
Ling
L
L
He
Z
Z
Zeng
Y
Y
D000818:Animals; D001665:Binding Sites; D002417:Cattle; D002614:Chelating Agents; D004247:DNA / Q000737:chemistry*; D015342:DNA Probes / Q000138:chemical synthesis; D007364:Intercalating Agents / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D008163:Luminescent Measurements; D009942:Organometallic Compounds; D010619:Phenazines; D017975:Ruthenium Compounds / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
D002614:Chelating Agents; D015342:DNA Probes; D007364:Intercalating Agents; D008024:Ligands; D009942:Organometallic Compounds; D010619:Phenazines; D017975:Ruthenium Compounds; C077849:bis(2,2'-bipyridyl)(dipyrido(3,2-alpha-2',3'-c)phenazine)ruthenium (II); D004247:DNA; C427203:calf thymus DNA