title: Advances in prophylactic cancer vaccine research.
abstract: Prophylactic vaccination against human cancer provides a unique opportunity to prevent human suffering for individuals at risk for tumor development. Appropriate vaccines may pose slightly different requirements than vaccines intended for therapeutic use. Prophylactic vaccines will need to prevent tumors far into the future, emphasizing the need to establish solid tumor-specific immunologic memory. Another important issue associated with prophylactic cancer vaccines is the identification of appropriate populations for vaccination. Individuals at risk may include those exposed to oncogenic viruses, those with occupational exposure to tumor promoting agents, and individuals with a family history of cancer. This paper addresses the specific challenges posed to the exciting field of prophylactic cancer vaccine research.
authors.affiliation: Cancer Immunology Program, Cardinal Bernardin Cancer Center, Maywood, IL 60153, USA. ilepool@lumc.edu
authors.forename: I Caroline
authors.initials: IC
authors.lastname: Le Poole
authors.forename: Hemamalini
authors.initials: H
authors.lastname: Bommiasamy
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bocchetta
authors.forename: W Martin
authors.initials: WM
authors.lastname: Kast
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control*
chemical_list: D019496:Cancer Vaccines