Science review: Genetic variability in the systemic inflammatory response.
The present review discusses recent studies that have identified genetic differences in inflammatory proteins associated with different phenotypic presentations of systemic inflammation. Basic genetic terminology is defined. Implications of genetic influences on the inflammatory response are discussed. The published associations of specific polymorphisms in antigen recognition pathways, proinflammatory cytokines, anti-inflammatory cytokines, and effector molecules are reviewed. The strongest and most consistent associations thus far have been with the tumor necrosis factor, lymphotoxin-alpha, and IL-1 receptor antagonist polymorphisms. However, large, phenotypically detailed studies are required to address all of the other potential polymorphisms in inflammatory molecule genes and their interactions.
Waterer
Grant W
GW
Department of Medicine, University of Western Australia, Australia.
Wunderink
Richard G
RG
D016207:Cytokines / Q000502:physiology; D014644:Genetic Variation; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D018836:Inflammation Mediators / Q000502:physiology; D010641:Phenotype
D016207:Cytokines; D018836:Inflammation Mediators