Effects of hypertonic saline, HAES and dimethylsulphoxide on free oxygen radicals in haemorrhagic shock oxygen radicals in haemorrhagic shock.
BACKGROUND
The aim of this study was to investigate the effects of antioxidant and resuscitation fluids which were used during haemorrhagic shock on tissue ischemia.


METHODS
Forty New Zealand type rabbits were divided into four groups as C (control), I (hypertonic saline), H (HAES) and D (Dimethylsulphoxide-DMSO). Haemorrhagic shock was induced by bleeding from carotid artery. Thirty minutes after shock, Group C was not resuscitated while Group I was resuscitated with Hypertonic saline 7.2, Group H with 10 % HAES and Group D with HAES 10 % and DMSO. Thiobarbituric acid reactive substances (TBARS) and lactate levels in blood, liver and small bowel samples were measured.


RESULTS
There were no significant differences among the groups tissue and plasma TBARS and lactate levels.


CONCLUSIONS
Resuscitation fluids and addition of antioxidants to the resuscitation fluids do not have any superiorities over each other to prevent tissue ischemic insult in haemorrhagic shock.
Bayir
Aysegül
A
Meram Medical Faculty of Selçuk University Emergency Department, Merman University Experimental Medicine and Research Center, 42080 Merman/Konya. a_bayir@hotmail.com
Kafali
M Ertuğrul
ME
Ak
Ahmet
A
Sahin
Mustafa
M
Karagözoğlu
Emrah
E
Gül
Mehmet
M
Karabulut
Kaan
K
D000818:Animals; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000378:metabolism; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D007421:Intestine, Small / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D011817:Rabbits; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000627:therapeutic use*; D012771:Shock, Hemorrhagic / Q000628:therapy*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D016166:Free Radical Scavengers; D012462:Saline Solution, Hypertonic; D017392:Thiobarbituric Acid Reactive Substances; D019344:Lactic Acid; D004121:Dimethyl Sulfoxide