title: The restriction of all minerals in the diet enhancing paraquat toxicity is regarded primarily as the shortage of Mg.
abstract: This study compares the effect of the restriction of Mg with that of all-minerals in the diet on the toxicity of paraquat. To compare the severity of the toxicity, several biological values were examined; kininogen in plasma, thiobarbituric acid reactive substances in liver, Ca level in kidney, and Mg levels in liver and kidney. Osteogenic disorder Shionogi rats that cannot synthesize vitamin C like humans did not display paraquat symptoms after receiving minute amounts of paraquat dichloride, i.e. 125 ppm in the diet for 8 days, and those biological values remained the same as those of the control. Rats fed with Mg at half of the recommended amounts also did not show any changes in those levels. The dosage of 125 ppm paraquat under the restriction of Mg, however, induced paraquat intoxication and increased those levels greatly. This result arises a question whether the intoxication is due to the imbalance of Ca and Mg or due to the shortage of Mg itself, because imbalance of Ca and Mg sometimes induces more serious effects than the shortage of Mg itself. Therefore, we fed rats an all-mineral restricted diet where the balance of Ca and Mg was maintained. The dosage of paraquat under all-mineral restriction, however, induced much more serious intoxication than that under Mg restriction. In conclusion, the shortage of Mg itself seems to be responsible for the induction of paraquat intoxication.
authors.affiliation: Department of Legal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan. kminakat@hama-med.ac.jp
authors.forename: Kayoko
authors.initials: K
authors.lastname: Minakata
authors.forename: Hideki
authors.initials: H
authors.lastname: Nozawa
authors.forename: Kanako
authors.initials: K
authors.lastname: Watanabe-Suzuki
authors.forename: Osamu
authors.initials: O
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D002118:Calcium / Q000032:analysis; D004032:Diet; D005247:Feeding Behavior; D006540:Herbicides / Q000633:toxicity*; D007668:Kidney / Q000737:chemistry; D007704:Kininogens / Q000097:blood; D008099:Liver / Q000737:chemistry; D008274:Magnesium / Q000008:administration & dosage* / Q000032:analysis / Q000378:metabolism*; D008275:Magnesium Deficiency / Q000378:metabolism*; D008297:Male; D010269:Paraquat / Q000633:toxicity*; D051381:Rats; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D006540:Herbicides; D007704:Kininogens; D017392:Thiobarbituric Acid Reactive Substances; D008274:Magnesium; D010269:Paraquat; D002118:Calcium