Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism.
Specific virus-receptor interactions are important determinants in the pathogenesis of viral infections, influencing the location and initiation of primary infection as well as the viral spread to other target organs in the postviremic phase. Coxsackieviruses of group B (CVB) specifically interact with at least two receptor proteins, the coxsackievirus-adenovirus receptor (CAR) and the decay-accelerating factor (DAF), and cause a broad spectrum of diseases, including acute and chronic myocarditis. In the human heart, CAR is predominantly expressed in intercalated discs, regions of utmost importance for the functional integrity of the heart. Since DAF is abundantly expressed in epithelial and endothelial cells, interaction of cardiotropic CVB with the DAF coreceptor protein, in addition to CAR, could therefore be advantageous to the virus by enhancing viral entry into the heart.
Selinka
Hans-Christoph
HC
Institut für Medizinische Mikrobiologie und Hygiene, Johannes-Gutenberg-Universität Mainz, Hochhaus am Augustusplatz, 55101 Mainz, Germany. selinka@mail.uni-mainz.de
Wolde
Antje
A
Sauter
Martina
M
Kandolf
Reinhard
R
Klingel
Karin
K
D018958:CD55 Antigens / Q000378:metabolism*; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D029822:Enterovirus B, Human / Q000472:pathogenicity*; D004769:Enterovirus Infections / Q000503:physiopathology / Q000821:virology; D006367:HeLa Cells; D006801:Humans; D009205:Myocarditis / Q000503:physiopathology* / Q000821:virology*; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D011991:Receptors, Virus / Q000378:metabolism*
D018958:CD55 Antigens; C568771:CLMP protein, human; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D011991:Receptors, Virus