Preparation and in vitro evaluation of GdDOTA-(BOM)4; a novel angiographic MRI contrast agent.
A novel Gd(III) complex, GdDOTA-(BOM)4, has been prepared by a simple three-step procedure. The complex showed high T1-relaxivity values in serum albumin solutions, blood and plasma, resulting from high affinity for serum albumin. The T1-relaxivity in plasma, 67.4 s-1 mM-1 (20 MHz, 37 degrees C), makes it a promising candidate for angiographic applications of MRI.
Hovland
Ragnar
R
Department of Medicinal Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1155, Blindern, N-0318 Oslo, Norway. ragnar.hovland@farmasi.uio.no
Aasen
Arne J
AJ
Klaveness
Jo
J
D000792:Angiography / Q000379:methods; D000818:Animals; D002417:Cattle; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D005682:Gadolinium / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009942:Organometallic Compounds / Q000097:blood* / Q000138:chemical synthesis* / Q000737:chemistry; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000378:metabolism
D003287:Contrast Media; D006573:Heterocyclic Compounds, 1-Ring; D009942:Organometallic Compounds; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D012710:Serum Albumin, Bovine; D005682:Gadolinium