title: Differences in the deflation limb of the pressure-volume curves in acute respiratory distress syndrome from pulmonary and extrapulmonary origin.
abstract: OBJECTIVE
  To assess the differences in the deflation pressure-volume (PV) curves between acute respiratory distress syndrome from pulmonary (ARDSp) and extrapulmonary (ARDSe) origin.
  
  
  METHODS
  . Prospective study.
  
  
  METHODS
  Twenty-bed intensive care unit in an university hospital.
  
  
  METHODS
  Ten patients within the first 24 h from meeting ARDS criteria, classified as ARDSp or ARDSe in a clinical basis.
  
  
  METHODS
  A deflation PV curve was recorded by means of decreasing steps of continuous positive airway pressure (CPAP) from 35 to 0 cmH(2)O.
  
  
  RESULTS
  The simultaneous recording of pressure at the airway opening (Pao), esophageal pressure (Pes) and volumes (V) allows us to trace the Pao-V, Pes-V and transpulmonary pressure (Ptp)-V curves. These data were fitted to a sigmoid model and ARDSp and ARDSe groups were compared. ARDSp has lower lung compliance and higher chest wall compliance than ARDSe (35.9+/-11.3 vs. 77.2+/-50.6 and 199.6+/-44.4 vs. 125.5+/-16.5 ml/cmH(2)O, respectively, P<0.05). The Pao-V curve in ARDSp is shifted down and right with respect to ARDSe. The Ptp-V curve shows a similar displacement. The Pes-V curve in the ARDSp group is, however, shifted to the left. When relative values (percentage to the maximum volume achieved at 35 cmH(2)O) are considered, these differences persist, but, in the Ptp-V curves, are only significant in the low-pressure range.
  
  
  CONCLUSIONS
  Differences between ARDSp and ARDSe PV curves are present all along the pressure axis and are related to differences not only in the Pes-V curve, but also in the Ptp-V curve.
authors.affiliation: Intensive Care Unit, Hospital Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain. gmuniz@hcas.insalud.es
authors.forename: Guillermo M
authors.initials: GM
authors.lastname: Albaiceta
authors.forename: Francisco
authors.initials: F
authors.lastname: Taboada
authors.forename: Diego
authors.initials: D
authors.lastname: Parra
authors.forename: Armando
authors.initials: A
authors.lastname: Blanco
authors.forename: Dolores
authors.initials: D
authors.lastname: Escudero
authors.forename: Jesús
authors.initials: J
authors.lastname: Otero
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001784:Blood Gas Analysis; D001827:Body Height; D001835:Body Weight; D015984:Causality; D003422:Critical Care / Q000379:methods; D005260:Female; D006785:Hospitals, University; D006801:Humans; D016018:Least-Squares Analysis; D008170:Lung Compliance; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration / Q000379:methods*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012128:Respiratory Distress Syndrome / Q000145:classification / Q000209:etiology* / Q000503:physiopathology*; D015656:Respiratory Mechanics; D016019:Survival Analysis; D013990:Tidal Volume; D016896:Treatment Outcome