Correlation between serum resistin level and adiposity in obese individuals.
OBJECTIVE
Resistin is associated with insulin resistance in mice and may play a similar role in humans. The aim of our study was to examine the relationship of serum resistin level to body composition, insulin resistance, and related obesity phenotypes in humans.


METHODS
Sixty-four young (age 32 +/- 10 years), obese (BMI 32.9 +/- 5.6), nondiabetic subjects taking no medication, and 15 lean (BMI 21.1 +/- 1.3) volunteers were studied cross-sectionally. Thirty-five of the subjects were also reevaluated after 1.5 years on a weight reduction program entailing dieting and exercise; changes of serum resistin were compared with changes of BMI, body composition, fat distribution, and several indices of insulin sensitivity derived from plasma glucose and serum insulin levels measured during 75-g oral glucose tolerance test.


RESULTS
In a cross-sectional analysis, serum resistin was significantly higher in obese subjects than in lean volunteers (24.58 +/- 12.93 ng/mL; n = 64 vs. 12.83 +/- 8.30 ng/mL; n = 15; p < 0.01), and there was a correlation between resistin level and BMI, when the two groups were combined (rho = 0.35, p < 0.01). Although cross-sectional analysis in obese subjects revealed no correlation between serum resistin and parameters related to adiposity or insulin resistance, longitudinal analysis revealed change in serum resistin to be positively correlated with changes in BMI, body fat, fat mass, visceral fat area, and mean glucose and insulin (rho = 0.39, 0.40, 0.44, 0.50, 0.40, and 0.50; p = 0.02, 0.03, 0.02, <0.01, 0.02, and <0.01, respectively).


CONCLUSIONS
Resistin appears to be related to human adiposity and to be a possible candidate factor in human insulin resistance.
Azuma
Koichiro
K
Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. SNA12474@nifty.com
Katsukawa
Fuminori
F
Oguchi
Shuji
S
Murata
Mitsuru
M
Yamazaki
Hajime
H
Shimada
Akira
A
Saruta
Takao
T
D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000502:physiology*; D003430:Cross-Sectional Studies; D015444:Exercise; D005260:Female; D005951:Glucose Tolerance Test; D006729:Hormones, Ectopic / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000097:blood* / Q000378:metabolism; D052243:Resistin; D018709:Statistics, Nonparametric; D015431:Weight Loss
D001786:Blood Glucose; D006729:Hormones, Ectopic; D036341:Intercellular Signaling Peptides and Proteins; C499624:RETN protein, human; C486574:RETNLB protein, human; D052243:Resistin