title: The issue of dynamic hyperinflation in acute respiratory distress syndrome patients.
abstract: Dynamic hyperinflation is produced by a diffuse expiratory flow limitation impairing exhalation under mechanical ventilation. It constitutes a serious clinical problem in patients exhibiting bronchial asthma or chronic obstructive pulmonary disease, when mechanical ventilation is required. But this phenomenon may also complicate respiratory support in acute respiratory distress syndrome (ARDS) patients. The presence of diffuse airflow limitation in ARDS patients has sometimes been noticed in the past, but its consequences have only recently been emphasised in a dynamic study, using bedside recording of flow/volume loops during respiratory support. More recently, by recording systematically a prolonged expiration, the current authors have observed a localised airflow limitation in a majority of ARDS patients, constituting another potential factor of dynamic hyperinflation under respiratory support. In the same report, the current authors' have emphasised the impact of this limitation on the shape of the pressure/volume loop. At a time when increasing respiratory support is proposed to improve carbon dioxide clearance in acute respiratory distress syndrome submitted to protective ventilation, dynamic hyperinflation may become a major clinical problem in this setting.
authors.affiliation: Medical Intensive Care Unit, University Hospital Ambroise Paré, Assistance Publique Hôpitaux de Paris, Boulogne, France.
authors.forename: A
authors.initials: A
authors.lastname: Vieillard-Baron
authors.forename: F
authors.initials: F
authors.lastname: Jardin
mesh_terms: D000403:Airway Resistance; D001249:Asthma / Q000503:physiopathology* / Q000628:therapy; D005541:Forced Expiratory Volume; D006801:Humans; D007320:Inspiratory Capacity; D008170:Lung Compliance; D011175:Positive-Pressure Respiration; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology* / Q000628:therapy; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000503:physiopathology* / Q000628:therapy; D015656:Respiratory Mechanics