Transsphenoidal hypophysectomy for four dogs with pituitary ACTH-producing adenoma.
Four dogs diagnosed as pituitary-dependent hyperadrenocorticism were treated with transsphenoidal hypophysectomy and postoperative hormone supplementation therapy. On histological examination of the resected tissues, the tumors were ACTH-producing adenoma of the anterior lobe. Clinical signs such as alopecia and calcinosis cutis, as well as endocrinological abnormalities, were markedly alleviated after surgery. The clinical courses of these 4 dogs suggest that transsphenoidal hypophysectomy may be a useful treatment for pituitary-dependent hyperadrenocorticism.
Hara
Yasushi
Y
Division of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Animal Science University, Tokyo, Japan.
Tagawa
Masahiro
M
Masuda
Hiroyuki
H
Sako
Toshinori
T
Koyama
Hidekazu
H
Orima
Hiromitsu
H
Nakamura
Shinichiro
S
Takahashi
Kimimasa
K
Sanno
Naoko
N
Teramoto
Akira
A
D000236:Adenoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery* / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D004285:Dogs; D005260:Female; D007016:Hypophysectomy / Q000379:methods* / Q000662:veterinary*; D008297:Male; D010902:Pituitary Gland / Q000601:surgery
D000324:Adrenocorticotropic Hormone