Cytotoxic naphthoquinones from roots of Lippia microphylla.
A new prenylated naphthoquinone dimer named microphyllaquinone (1), a mixture of 6-methoxy- and 7-methoxy-naphtho[2,3-b]-furan-4,9-quinones (2a/2b) and tecomaquinone I (3), were isolated from roots of Lippia microphylla. The structures were elucidated by spectroscopic methods, including detailed 1D and 2D (COSY, NOESY, HMQC, HMBC) NMR data. Unpublished 13C NMR data of 2a and 2b are reported. The in vitro cytotoxic activity of the isolated compounds was tested against five types of tumor cells.
Santos
Hélcio S
HS
Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, CP 12200, 60451-970 Fortaleza, Ceará, Brazil.
Costa
Sônia M O
SM
Pessoa
Otília D L
OD
Moraes
Manoel O
MO
Pessoa
Claudia
C
Fortier
Sergio
S
Silveira
Edilberto R
ER
Lemos
Telma L G
TL
D000818:Animals; D001943:Breast Neoplasms; D002470:Cell Survival / Q000187:drug effects*; D003110:Colonic Neoplasms; D005260:Female; D018922:HL-60 Cells; D006801:Humans; D032411:Lippia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008546:Melanoma, Experimental; D051379:Mice; D009285:Naphthoquinones / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry*; D010947:Plants, Toxic / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D009285:Naphthoquinones; D010936:Plant Extracts