The pterocellins, novel bioactive alkaloids from the marine bryozoan Pterocella vesiculosa.
Two new alkaloids, pterocellins A and B, have been isolated from the New Zealand marine bryozoan Pterocella vesiculosa. Structural elucidation was achieved through NMR and mass spectral analysis in conjunction with a single-crystal X-ray diffraction study of pterocellin A. The pterocellins possess a novel heterocyclic skeleton and exhibit potent antitumor activity and antimicrobial activity in vitro but only modest activity in the in vivo hollow fiber assay at the National Cancer Institute.
Yao
Biao
B
Department of Chemistry, University of Waikato, Private Bag 3105, Hamilton, New Zealand.
Prinsep
Michèle R
MR
Nicholson
Brian K
BK
Gordon
Dennis P
DP
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002013:Bryozoa / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular
D000470:Alkaloids; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D006575:Heterocyclic Compounds, 3-Ring; C479813:pterocellin A; C479814:pterocellin B