Serum biochemical markers in carcinoma breast.
BACKGROUND
Despite the extensive research for many years throughout the world, the etiopathogenesis of cancer still remains obscure. For the early detection of carcinoma of various origins, a number of biochemical markers have been studied to evaluate the malignancy.


OBJECTIVE
To analyse serum gamma glutamyl transpeptidase (GGTP), lactate dehydrogenase (LDH) and superoxide dismutase (SOD) in carcinoma breast patients.


METHODS
The serum biochemical markers were estimated in twenty five histopathologically confirmed patients with carcinoma breast and equal number of healthy age- matched individuals served as control.


METHODS
Serum gamma glutamyl transpeptidase (GGTP), lactate dehydrogenase (LDH) and superoxide dismutase (SOD) were estimated and their sensitivity determined.


METHODS
Data was analysed with student's 't'-test and sensitivity score of these markers was determined.


CONCLUSIONS
The mean serum GGTP, LDH and SOD activities in patients with carcinoma breast were tremendously increased as compared to controls, and a steady increase was observed in their activities from stage I through stage IV as well as following distant metastasis. Serum GGTP, LDH and SOD might prove to be most sensitive biomarkers in carcinoma breast in early detection of the disease.
Seth
Late R K
LR
Department of Biochemistry, Pt. B.D. Sharma PGIMS, Rohtak, Haryana.
Kharb
Simmi
S
Kharb
D P
DP
D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000097:blood; D018275:Carcinoma, Lobular / Q000097:blood; D018450:Disease Progression; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D009367:Neoplasm Staging; D012016:Reference Values; D012680:Sensitivity and Specificity; D013482:Superoxide Dismutase / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D014408:Biomarkers, Tumor; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D005723:gamma-Glutamyltransferase