Correlation of 4- and 24-hour urine protein in women with initially diagnosed hypertensive disorders in pregnancy.
OBJECTIVE
To determine whether 4-hour urine protein value correlates with 24-hour urine protein value in women with hypertensive disorders in pregnancy.


METHODS
Cross-sectional study was performed in 38 in-patient pregnant women who were initially diagnosed as having hypertensive disorders in pregnancy. Urine samples were collected within 24 hours in 2 successive periods: the first 4-hour and the next 20-hour urine, in separate containers. The urine volume, urine protein and creatinine concentrations were thus separately measured. The 4- and 24-hour urine proteins were calculated and the correlation between both groups was determined by simple linear regression analysis.


RESULTS
A total of 38 patients were recruited into the study, 26 had mild preeclampsia, 5 had severe preeclampsia, and 7 had superimposed preeclampsia. The result of the 4-hour urine protein was found to correlate with those of the 24-hour urine protein for patients with hypertensive disorders in pregnancy (p < 0.001).


CONCLUSIONS
Total protein values of 4-hour samples positively correlated with values of 24-hour samples of patients with hypertensive disorders in pregnancy. This might be modified and used for urine protein collection in outpatients to improve the compliance.
Wongkitisophon
Kitti
K
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Phupong
Vorapong
V
Yamasmit
Waralak
W
Pansin
Pongsak
P
Tannirandorn
Yuen
Y
Charoenvidhya
Dhiraphongs
D
D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000652:urine*; D016014:Linear Models; D011225:Pre-Eclampsia / Q000652:urine*; D011247:Pregnancy; D011507:Proteinuria / Q000175:diagnosis*; D013048:Specimen Handling; D013997:Time Factors