title: Volume transmission and pain perception.
abstract: Volume transmission (VT) is the diffusion through the brain extracellular fluid of neurotransmitters released at points that may be remote from the target cells with the resulting activation of extrasynaptic receptors. VT appears to play multiple roles in the brain in normal and abnormal activity, brain plasticity and drug actions. The relevance of VT to pain perception has been explored in this review.
authors.affiliation: Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, México, D.F. 07300, Mexico. gcastane@mail.cinvestav.mx
authors.forename: Gilberto C
authors.initials: GC
authors.lastname: Castañeda-Hernández
authors.forename: Paul
authors.initials: P
authors.lastname: Bach-y-Rita
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D004058:Diffusion; D045604:Extracellular Fluid / Q000378:metabolism; D006801:Humans; D006930:Hyperalgesia / Q000209:etiology / Q000503:physiopathology; D009473:Neuronal Plasticity; D018377:Neurotransmitter Agents / Q000378:metabolism; D010146:Pain / Q000209:etiology* / Q000503:physiopathology*; D010465:Perception / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D018377:Neurotransmitter Agents