The evolving role of platelets in inflammation.
Platelets are small in size and simple in structure. Nevertheless, these anucleate cytoplasts utilize complex molecular systems to regulate a variety of biological functions. Here we review evolutionary paths, traditional roles, and previously unrecognized biological capacities of platelets that interface thrombosis with inflammation and potentially identify new roles in inflammatory diseases.
Weyrich
A S
AS
Department of Internal Medicine and the Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA. andy.weyrich@hmbg.utah.edu
Lindemann
S
S
Zimmerman
G A
GA
D001792:Blood Platelets / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology*; D016023:Integrins / Q000502:physiology; D010802:Phylogeny; D015539:Platelet Activation; D013927:Thrombosis / Q000097:blood / Q000209:etiology
D016023:Integrins