title: Water and sodium disorders in children undergoing surgical treatment of brain tumors.
abstract: BACKGROUND
  Many children with brain tumors have abnormalities in water and sodium homeostasis, such as diabetes insipidus (DI), the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral salt wasting syndrome (CSW), either pre-operatively or post-operatively. But little data have been published on the incidence, time of onset and clinical course of water and sodium disorders in children with brain tumors.
  
  
  OBJECTIVE
  To characterize the water and sodium disorders in children undergoing surgical treatment for brain tumors.
  
  
  METHODS
  The medical records of children with brain tumors admitted for surgery at King Chulalongkorn Memorial Hospital from January 1997 to December 2002 were retrospectively reviewed.
  
  
  RESULTS
  There were 79 patients, 46 males and 33 females included in this study. Water and sodium disorders occurred in 36 patients (45.57%), 23 patients had DI, 12 patients had SIADH and 1 patient had cerebral salt wasting syndrome (CSW). Nine of the 36 patients had pre-operative onset of water and sodium disorders (8 DI and 1 SIADH). The development of DI and SIADH was associated with the location of the brain tumors. Patients with sellar and suprasellar tumors had the highest incidence of DI (75.86%). Patients with tumors of the cerebral hemispheres had the highest incidence of SIADH (44.44%). Onset of post-operative DI ranged from 2 to 19 hours (mean 9.68 hours) and most patients developed SIADH within 24 hours post-operatively.
  
  
  CONCLUSIONS
  DI and SIADH are common problems in children with brain tumors, especially after surgical treatment and the onset usually occurs within 24 hours after surgery. Patients with sellar and suprasellar tumors are more likely to have DI, patients with tumors of cerebral hemispheres and posterior fossa tumors are more likely to have SIADH.
authors.affiliation: Endocrine unit, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Paravee
authors.initials: P
authors.lastname: Hiranrat
authors.forename: Pisut
authors.initials: P
authors.lastname: Katavetin
authors.forename: Vichit
authors.initials: V
authors.lastname: Supornsilchai
authors.forename: Suttipong
authors.initials: S
authors.lastname: Wacharasindhu
authors.forename: Sumarlee
authors.initials: S
authors.lastname: Srivuthana
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications* / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011183:Postoperative Complications; D012189:Retrospective Studies; D014883:Water-Electrolyte Imbalance / Q000209:etiology*