title: Synthesis of 4-octyl-2H-1,4-benzo-thiazin-3-ones.
abstract: Synthesis, physical and analytical properties of 6-alkylacylamino-4-octyl-2H-1,4-benzo-thiazin-3-ones derivatives are described. These new compounds were prepared by acylation and/or alkylation of the amino group under phase transfer catalysis conditions. Acid hydrolysis of the alkylacylamino-2H-1,4-benzo-thiazin-3-ones afforded N-alkylamino-benzothiazin-3-ones. Some of these compounds were evaluated in vitro for possible bacteriostatic activity.
authors.affiliation: Laboratoire de chimie pharmacie, UPRESA CNRS 5077, Université Joseph-Fourier, Grenoble I, 38706, La Tronche, Cedex, France.
authors.forename: Vera L de M
authors.initials: VL
authors.lastname: Guarda
authors.forename: Monique
authors.initials: M
authors.lastname: Perrissin
authors.forename: François
authors.initials: F
authors.lastname: Thomasson
authors.forename: Eulalia A
authors.initials: EA
authors.lastname: Ximenes
authors.forename: Suely L
authors.initials: SL
authors.lastname: Galdino
authors.forename: Ivan R
authors.initials: IR
authors.lastname: Pitta
authors.forename: Cuong
authors.initials: C
authors.lastname: Luu-Duc
authors.forename: Jacques
authors.initials: J
authors.lastname: Barbe
mesh_terms: D000215:Acylation; D000478:Alkylation; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006868:Hydrolysis; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C446962:1,4-benzothiazine; D000890:Anti-Infective Agents; D013843:Thiazines