title: Magnetic resonance imaging measurement of knee cartilage volume in a multicentre study.
abstract: OBJECTIVE
  To investigate the variability between different high-field scanners in magnetic resonance imaging (MRI) measurement of knee cartilage volume in healthy female volunteers.
  
  
  METHODS
  Five volunteers had both knees scanned using three different MRI scanners. Cartilage volume in each compartment was measured from the images by image segmentation. The data were analysed using analysis of variance models.
  
  
  RESULTS
  The mean total cartilage volume of the 10 knees scanned at three different centres was 16.15, 16.40 and 15.63 ml for the Siemens, GE and Philips scanners respectively. Small systematic differences were seen in the total knee cartilage volume results.
  
  
  CONCLUSIONS
  Although there were small systematic differences in knee cartilage volume, the three MRI scanners gave broadly similar results.
authors.affiliation: AstraZeneca, Macclesfield, UK. shethah.morgan@astrazeneca.com
authors.forename: S R
authors.initials: SR
authors.lastname: Morgan
authors.forename: J C
authors.initials: JC
authors.lastname: Waterton
authors.forename: R A
authors.initials: RA
authors.lastname: Maciewicz
authors.forename: J E
authors.initials: JE
authors.lastname: Leadbetter
authors.forename: S J
authors.initials: SJ
authors.lastname: Gandy
authors.forename: R J
authors.initials: RJ
authors.lastname: Moots
authors.forename: P
authors.initials: P
authors.lastname: Creamer
authors.forename: A F P
authors.initials: AF
authors.lastname: Nash
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D019412:Anatomy, Cross-Sectional; D002358:Cartilage, Articular / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008875:Middle Aged; D012680:Sensitivity and Specificity