title: [Occult pancreatobiliary reflux and gallbladder carcinoma].
abstract: A total of 108 patients with a normal pancreaticobiliary junction who had gallbladder wall thickness as shown by ultrasonography or computed tomography underwent secretin injection magnetic resonance cholangiopancreatography. Based on the changes in the diameter of the biliary system after secretin injection, patients were categorized into the intensified group (n = 19) or the non-intensified group (n = 89). The mean (+/- SD) biliary amylase level in the bile duct was 41674 (+/- 59779) IU/L in the intensified group, which was significantly higher than that in the non-intensified group (210 (+/- 418)) IU/L (p < 0.0001). There were four patients with carcinoma of the gallbladder in the intensified group and their biliary amylase level in the bile duct was 90783 (+/- 82528) IU/L. Pancreatobiliary reflux similar to that seen in patients with pancreaticobiliary maljunction can occur in persons with a normal pancreaticobiliary junction and this may be associated with carcinoma of the gallbladder. Secretin injection magnetic resonance cholangiopancreatography proved useful to identify such persons.
authors.affiliation: Department of Gastroenterology, Juntendo University.
authors.forename: Jin Kan
authors.initials: JK
authors.lastname: Sai
authors.forename: Masafumi
authors.initials: M
authors.lastname: Suyama
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kubokawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tadokoro
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Koshikawa
authors.forename: Hironao
authors.initials: H
authors.lastname: Ookubo
authors.forename: Kei
authors.initials: K
authors.lastname: Kato
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsumura
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Satou
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawasaki
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Kojima
authors.forename: Bunsei
authors.initials: B
authors.lastname: Nobukawa
authors.forename: Kouichi
authors.initials: K
authors.lastname: Suda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Tsushima
authors.forename: Hideki
authors.initials: H
authors.lastname: Mori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001652:Bile Ducts / Q000473:pathology*; D001655:Bile Reflux / Q000175:diagnosis*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D005260:Female; D005706:Gallbladder Neoplasms / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010183:Pancreatic Ducts / Q000473:pathology*; D012633:Secretin
chemical_list: D012633:Secretin