title: Clinical spectrum of hepatic tuberculosis: comparison between immunocompetent and immunocompromised hosts.
abstract: BACKGROUND
  Hepatic tuberculosis has been reported in normal and immunocompromised hosts. However, no published comparisons between these two groups of subjects with hepatic tuberculosis have been found. The aim of this study was to compare the clinical manifestations, biochemical tests, radiologic features and pathological findings of hepatic tuberculosis in immunocompromised and immunocompetent patients.
  
  
  METHODS
  The authors reviewed retrospectively 20 patients with hepatic tuberculosis admitted between January 1993 and October 2000 to Chulalongkorn University Hospital, Thailand. There were 12 immunocompromised patients (10 HIV-infected males, 1 systemic lupus erythematosus (SLE) male, 1 SLE female) and 8 immunocompetent patients (6 males, 2 females). The clinical manifestations, biochemical tests, radiologic features and pathological findings were compared between these 2 groups. The diagnosis of Mycobacterium tuberculosis (M. tb) was the combination of a demonstrated organism in hemo- or specimen culture, histopathology (positive acid fast bacilli) and rapid identification of M. tb from nested polymerase chain reaction (nPCR) assay based on amplification of the IS 6110 insertion sequences.
  
  
  RESULTS
  The clinical features were similar in both groups with fever, weight loss and hepatomegaly as the main manifestations. The biochemical findings were also similar but the alkaline phosphatase (ALP) was significantly higher in the immunocompromised group (p < 0.001). Hepatomegaly and diffuse increased echogenicity were common in both groups. Ascitis and calcifications were found more commonly in the immunocompetent subjects, although the differences were not statistically significant. Non-caseating granuloma without detection of acid fast bacilli was a common finding in both groups. The nested PCR assay increased the sensitivity from 49 per cent to 86 per cent compared to the regular PCR assay but specificity was 100 per cent in both techniques. The mortality was significantly higher in immunocompetent patients (p < 0.05) due to the extreme age and severe coexisting diseases.
  
  
  CONCLUSIONS
  Fever, weight loss, hepatomegaly, disproportionate elevation of ALP and reverse A/G ratio were common in hepatic tuberculosis. A disproportionate elevation of ALP was significantly higher in the immunocompromised hosts. Nested PCR assay showed good sensitivity and specificity in the diagnosis of this disease.
authors.affiliation: Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Ratha-korn
authors.initials: RK
authors.lastname: Vilaichone
authors.forename: Warakarn
authors.initials: W
authors.lastname: Vilaichone
authors.forename: Somying
authors.initials: S
authors.lastname: Tumwasorn
authors.forename: Pongsepeera
authors.initials: P
authors.lastname: Suwanagool
authors.forename: Henry
authors.initials: H
authors.lastname: Wilde
authors.forename: Varocha
authors.initials: V
authors.lastname: Mahachai
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007121:Immunocompetence / Q000276:immunology*; D016867:Immunocompromised Host / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014386:Tuberculosis, Hepatic / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism*