title: Interleukin-18 levels in the plasma of psoriatic patients correlate with the extent of skin lesions and the PASI score.
abstract: Interleukin-18 is a cytokine with a possible role in the pathogenesis of psoriasis. We examined subpopulations of peripheral blood lymphocytes and their expression of activation markers and correlated this with plasma levels of IL-18 and clinical disease severity in patients with psoriasis. We included 12 patients with psoriasis who had a PASI score from 15 to 48 and compared them to controls. IL-18 plasma concentrations were determined with an enzyme-linked immunosorbent assay. We observed a significant correlation between the IL-18 levels and the area of skin affected with psoriasis and the PASI score. We also observed an increase in NK cells and memory helper CD45RO + /CD4+cells.
authors.affiliation: Department of Dermatology, Medical University, Lublin, Poland. patrycjamikulska@wp.pl
authors.forename: Aldona
authors.initials: A
authors.lastname: Pietrzak
authors.forename: Barbara
authors.initials: B
authors.lastname: Lecewicz-Torun
authors.forename: Grazyna
authors.initials: G
authors.lastname: Chodorowska
authors.forename: Jacek
authors.initials: J
authors.lastname: Rolinski
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D016131:Lymphocyte Subsets / Q000145:classification; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D020382:Interleukin-18