A direct synthesis of 1-aryl- and 1-alkenylcyclopropylamines from aryl and alkenyl nitriles.
The reaction of various aromatic nitriles with 1.1 equiv of Ti(Oi-Pr)(4) and 2.2 equiv of EtMgBr followed by addition of a Lewis acid gave 1-aryl cyclopropylamines in 43-76% yields. Under similar conditions, conjugated alkenenitriles afford 1-alkenylcyclopropylamines (42-65%).
Bertus
Philippe
P
CNRS UMR 6519, Réactions Sélectives et Applications, Université de Reims-Champagne-Ardenne, BP 1039, 51687 Reims Cedex 2, France. philippe.bertus@univ-reims.fr
Szymoniak
Jan
J