title: Long-term protective immune response elicited by vaccination with an expression genomic library of Toxoplasma gondii.
abstract: Immunization of BALB/c mice with an expression genomic library of Toxoplasma gondii induces a Th1-type immune response, with recognition of several T. gondii proteins (21 to 117 kDa) and long-term protective immunity against a lethal challenge. These results support further investigations to achieve a multicomponent anti-T. gondii DNA vaccine.
authors.affiliation: Laboratory of Autoimmunity and Immunoregulation, Department of Immunology, Oswaldo Cruz Institute, Rio de Janeiro, Brazil.
authors.forename: Alberto
authors.initials: A
authors.lastname: Fachado
authors.forename: Alexandro
authors.initials: A
authors.lastname: Rodriguez
authors.forename: Judith
authors.initials: J
authors.lastname: Molina
authors.forename: Jaline C
authors.initials: JC
authors.lastname: Silvério
authors.forename: Ana P M P
authors.initials: AP
authors.lastname: Marino
authors.forename: Luzia M O
authors.initials: LM
authors.lastname: Pinto
authors.forename: Sergio O
authors.initials: SO
authors.lastname: Angel
authors.forename: Juan F
authors.initials: JF
authors.lastname: Infante
authors.forename: Yara
authors.initials: Y
authors.lastname: Traub-Cseko
authors.forename: Regina R
authors.initials: RR
authors.lastname: Amendoeira
authors.forename: Joseli
authors.initials: J
authors.lastname: Lannes-Vieira
mesh_terms: D000818:Animals; D015870:Gene Expression; D018503:Genome, Protozoan; D015698:Genomic Library; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016052:Protozoan Vaccines / Q000008:administration & dosage* / Q000235:genetics; D018417:Th1 Cells / Q000276:immunology; D013997:Time Factors; D014122:Toxoplasma / Q000235:genetics / Q000276:immunology*; D014124:Toxoplasmosis, Animal / Q000276:immunology / Q000517:prevention & control; D014611:Vaccination; D019444:Vaccines, DNA / Q000235:genetics / Q000494:pharmacology*
chemical_list: D016052:Protozoan Vaccines; D019444:Vaccines, DNA