title: Relationship between protein structures and disulfide-bonding patterns.
abstract: We found that that disulfide-bonding patterns can be used to discriminate structure similarity. Our method, based on the hierarchical clustering scheme, is applicable to proteins with two or more disulfide bonds and is able to detect the structural similarities of proteins of low sequence identities (<25%). Our results show the surprisingly close relationship between disulfide-bonding patterns and proteins structures. Our findings should be useful in protein structure modeling.
authors.affiliation: Department of Life Sciences, Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsin Chu, Taiwan.
authors.forename: Chao-Chun
authors.initials: CC
authors.lastname: Chuang
authors.forename: Chun-Yin
authors.initials: CY
authors.lastname: Chen
authors.forename: Jinn-Moon
authors.initials: JM
authors.lastname: Yang
authors.forename: Ping-Chiang
authors.initials: PC
authors.lastname: Lyu
authors.forename: Jenn-Kang
authors.initials: JK
authors.lastname: Hwang
mesh_terms: D004220:Disulfides / Q000737:chemistry*; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry / Q000145:classification; D017386:Sequence Homology, Amino Acid
chemical_list: D004220:Disulfides; D011506:Proteins