A review of olanzapine-associated toxicity and fatality in overdose.
OBJECTIVE
Given the increasing use of atypical antipsychotics in psychiatric populations and the very limited data concerning the safety of such drugs, we examined the available data on olanzapine in untreated overdose situations.


METHODS
Available toxicity data concerning olanzapine were obtained from the Offices of the Medical Examiners of Canada, the Canadian Adverse Drug Reaction Monitoring Program and a review of the literature.


RESULTS
Despite the complexities and limitations of postmortem data analysis, 29 deaths were identified where an overdose of olanzapine was either the principal cause of toxicity or a significant contributor in combined toxicity.


CONCLUSIONS
Olanzapine is associated with toxicity in certain overdose situations, but evidence of any relation is limited and likely influenced by the higher rates of cardiovascular disease and sudden death in subjects with schizophrenia.


CONCLUSIONS
Similar toxicity data reviews should be conducted for all commonly prescribed psychotropics. Early signal detection and effective notification processes are crucial in the event that serious adverse effects do occur.
Chue
Pierre
P
Department of Psychiatry, University of Alberta and Alberta Hospitals. pchue@ualberta.ca
Singer
Peter
P
D014150:Antipsychotic Agents / Q000506:poisoning* / Q000627:therapeutic use; D001569:Benzodiazepines; D062787:Drug Overdose / Q000401:mortality; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000401:mortality*; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000506:poisoning* / Q000627:therapeutic use; D012307:Risk Factors
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine