title: First one-pot copper-catalyzed synthesis of alpha-hydroxy-beta-amino acids in water. A new protocol for preparation of optically active norstatines.
abstract: Alpha-hydroxy-beta-amino acids were synthesized with excellent yields for the first time in water and by a simple procedure based on a copper catalytic cycle, which included the recovery and reuse of the catalyst and is possible to realize by using only water as reaction medium.
authors.affiliation: Dipartimento di Chimica, Università di Perugia, 06123 Perugia, Italy. firfra@unipg.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Fringuelli
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Pizzo
authors.forename: Mauro
authors.initials: M
authors.lastname: Rucci
authors.forename: Luigi
authors.initials: L
authors.lastname: Vaccaro
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000596:Amino Acids; D001386:Azides; D008670:Metals; D014867:Water; D003300:Copper