[Local immune response to live cold-adapted reassortant influenza vaccine in children, adults, and aged people].
A study was conducted to compare the production of the serum and local IgA-antibodies in persons of different age groups (aged: 3-6, 7-14, 18-30, 65-89) after a single intranasal immunization with trivalent live cold-adapted reassortant of influenza vaccine (LIV). The geometric mean of titers of local IgA-antibodies increased, during post-vaccination period, against influenza viruses A(H1N1), A(H3N2) and B as much as people's age went up. It is noteworthy, that the parameters of the young and elderly did not virtually differ. As for the children, aged 3-6 and especially 7-14, an active local immune response developed in them to the LIV administration. Thus, no pronounced age-related immunologic insufficiency was found in children, aged 3-14, or in the elderly above 65 to the induced local response caused by LIV.
Donina
S A
SA
Naĭkhin
A N
AN
Grigor'eva
E P
EP
Desheva
Iu A
IuA
Barantseva
I B
IB
Rekstin
A R
AR
Rudenko
L G
LG
D000222:Adaptation, Physiological; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003080:Cold Temperature; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007252:Influenza Vaccines / Q000276:immunology*; D010919:Placebos; D016865:Reassortant Viruses / Q000276:immunology* / Q000502:physiology
D007070:Immunoglobulin A; D007252:Influenza Vaccines; D010919:Placebos