title: Immunophenotypic characterization of hepatic inflammatory cell infiltrates in common dolphins (Delphinus delphis).
abstract: Of 14 common dolphins, 12 showed non-specific reactive hepatitis and three chronic parasitic cholangitis with lymphoid proliferation. Non-specific reactive hepatitis was shown immunohistochemically to be associated with small clusters of CD3(+) cells in portal areas and hepatic sinusoids. Polyclonal antibody against S100 protein reacted with a variable number of lymphocytes from portal areas and hepatic sinusoids, as well as with Kupffer cells and epithelial cells of the bile ducts. The majority of plasma cells observed in portal areas and hepatic sinusoids were IgG(+). In lymphonodular lesions of chronic parasitic cholangitis, the distribution of immunoreactive cells was similar to that found in the cortex of lymph nodes. The presence of stellate cells similar to follicular dendritic and interdigitating cells expressing S-100 protein and MHC class II antigen in lymphonodular lesions suggested that these were highly organized structures developed to enhance antigen presentation to B and T cells.
authors.affiliation: Departamento de Morfología, Facultad de Veterinaria de Las Palmas de Gran Canaria, Spain.
authors.forename: J R
authors.initials: JR
authors.lastname: Jaber
authors.forename: J
authors.initials: J
authors.lastname: Pérez
authors.forename: M
authors.initials: M
authors.lastname: Arbelo
authors.forename: P
authors.initials: P
authors.lastname: Herráez
authors.forename: A
authors.initials: A
authors.lastname: Espinosa de los Monteros
authors.forename: F
authors.initials: F
authors.lastname: Rodńguez
authors.forename: T
authors.initials: T
authors.lastname: Fernández
authors.forename: A
authors.initials: A
authors.lastname: Fernández
mesh_terms: D000818:Animals; D017252:CD3 Complex / Q000032:analysis; D002452:Cell Count; D002761:Cholangitis / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D004289:Dolphins; D006520:Hepatitis, Animal / Q000276:immunology / Q000473:pathology*; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007124:Immunoenzyme Techniques / Q000662:veterinary; D016130:Immunophenotyping / Q000662:veterinary; D008099:Liver / Q000473:pathology*; D010273:Parasitic Diseases, Animal / Q000276:immunology / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis
chemical_list: D017252:CD3 Complex; D000949:Histocompatibility Antigens Class II; D009418:S100 Proteins