title: Extraorbital sebaceous carcinoma with rapidly developing visceral metastases.
abstract: BACKGROUND
  Extraorbital sebaceous carcinoma (SC) is a rare carcinoma of the skin but is known to have a good prognosis in terms of metastasis and survival.
  
  
  OBJECTIVE
  To discuss and emphasize through the clinical and histopathologic findings and the aggressive potential of extraorbital SC and to review the corresponding literature.
  
  
  METHODS
  We present an unusual form of extraorbital SC that has followed an aggressive course and that has metastasized rapidly.
  
  
  RESULTS
  Local excision of the primary cutaneous tumor with negative margins did not prevent the rapid and fatal internal organ metastases. The patient did not benefit from the docetaxel chemotherapy regimen applied after the distant metastases were developed.
  
  
  CONCLUSIONS
  Extraorbital SC may show a poor prognosis. Both the dermatologic surgeon and the dermatologist should be cautious of the risk of local recurrence and distant metastasis when dealing with extraorbital SC.
authors.affiliation: Department of Internal Medicine, Marmara University Hospital, 81060 Ciftehavuzlar, Istanbul, Turkey. drduman@excite.com
authors.forename: Deniz Güney
authors.initials: DG
authors.lastname: Duman
authors.forename: Berrin Bagci
authors.initials: BB
authors.lastname: Ceyhan
authors.forename: Turgay
authors.initials: T
authors.lastname: Celikel
authors.forename: Rengin
authors.initials: R
authors.lastname: Ahiskali
authors.forename: Dursun
authors.initials: D
authors.lastname: Duman
mesh_terms: D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D000077143:Docetaxel; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy / Q000473:pathology*; D009915:Orbit; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012626:Sebaceous Gland Neoplasms / Q000188:drug therapy / Q000473:pathology*; D043823:Taxoids; D014781:Viscera
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel