Applications of immobilised artificial membrane chromatography to quaternary alkylammonium sulfobetaines and comparison of chromatographic methods for estimating the octanol-water partition coefficient.
The chromatographic behaviour of a series of quaternary alkylammonium sulfobetaines of general formula RN-(CH3)2(CH2)nSO3-, where n = 2-4, has been examined using an immobilised artificial membrane column. The k values have been correlated both with experimentally determined values for the octanol-water partition coefficient (P) and with aquatic toxicity measurements. Other indirect chromatographic methods for measuring log P for these compounds using reversed-phase columns and octanol-coated columns have also been investigated.
Ward
Robert S
RS
University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK. r.s.ward@swan.ac.uk
Davies
Joanna
J
Hodges
Geoffrey
G
Roberts
David W
DW
D001622:Betaine / Q000031:analogs & derivatives* / Q000302:isolation & purification*; D002853:Chromatography, Liquid / Q000379:methods*; D008567:Membranes, Artificial; D000442:Octanols / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000302:isolation & purification*; D014867:Water / Q000737:chemistry*
D008567:Membranes, Artificial; D000442:Octanols; D000644:Quaternary Ammonium Compounds; C121744:ammonium sulfobetaine-1; D014867:Water; D001622:Betaine