Disorders of sex hormone status in patients with chronic obstructive pulmonary disease.
The aim of the study was to assess relations of endocrine status of sex glands, hypophysis, cortex of adrenal glands and the stages of chronic obstructive pulmonary disease (COPD) development in 197 males. The subjects were divided according to the severity into: CNB (chronic nonobstructive bronchitis)-->COPDT1 (mild)-->COPD2 (moderate)-->CCCP-->CDCP (serious COPD with compensative and decompensative cor pulmonale respectively). In CNB the rise of testosterone level (by 31%; p < 0.05) was noted. COPD1,2 CCCP, CDCP revealed the reduction of this hormone (less than controls by 1.2, 1.3, 1.4 and 1.6 times respectively; p < 0.05). In CNB the level of estradiole exceeded the control value (by 69%; p < 0.05), but in COPD1,2, CCCP and CDCP it was twice as high. The levels of luteinizing and follicle-stimulating hormones were raised significantly and compensatively (to a greater degree in COPD1,2). The basal level of cortisol exceeded the normal one in all patients' groups, particularly in COPD1 (by 1.6 times; p < 0.05). The level of aldosterone in all patients' groups was higher than in the control group.


CONCLUSIONS
The intensity of sex hormones changes in males correlated with the stages of COPD development. Estrogenization and androgen insufficiency in males indicates the certain pathogenic importance of sex hormone imbalance in COPD progression.
Makarevich
Aleksandr E
AE
Department of Internal Diseases N1, Belarusian State Medical University in Minsk.
D000328:Adult; D000367:Age Factors; D000450:Aldosterone / Q000097:blood; D016022:Case-Control Studies; D018450:Disease Progression; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism*; D012720:Severity of Illness Index; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D012739:Gonadal Steroid Hormones; D013739:Testosterone; D000450:Aldosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D006854:Hydrocortisone