[Antioxidant and antihypoxic effects of the ceruloplasmin preparation in the hypobaric hypoxia model].
The antioxidant and antihypoxant effects of the drug ceruloplasmin were studied on an experimental model of hypobaric hypoxia in rats. Two forms of the drug characterized by low and high enzymatic activity were administered (intramuscularly or intraperitoneally) 20 min or 1 day before hypobaric hypoxia test. The drug effect was independent of the enzymatic activity level. The maximum activity of ceruloplasmin was observed when the drug was administered one day before test. Analyses showed that the drug activated superoxide dismutase, while not changing the catalase activity.
Kraĭnova
T A
TA
ImBio Company, State Enterprise for Production of Bacterial Preparations, Gruzinskaya ul. 44, Nizhni Novgorod, 603950 Russia.
Efremova
L M
LM
Mukhina
I V
IV
Anastasiev
V V
VV
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D002374:Catalase / Q000097:blood; D002570:Ceruloplasmin / Q000008:administration & dosage / Q000494:pharmacology*; D000860:Hypoxia / Q000378:metabolism / Q000401:mortality / Q000517:prevention & control*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051381:Rats; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D002374:Catalase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin