Neuropsychological effects of chronic methamphetamine use on neurotransmitters and cognition: a review.
Methamphetamine use is on the rise, with an imminent upsurge of abuse and dependence reported across the United States. Currently, preliminary evidence suggests that methamphetamine dependence may cause long-term neural damage in humans, with concomitant deleterious effects on cognitive processes such as memory and attention. This selective review provides an outline and synthesis of studies that assess the neurotoxic mechanisms of methamphetamine, as well as those that evaluate the cognitive sequelae of methamphetamine abuse.
Nordahl
Thomas E
TE
Department of Psychiatry, University of California Davis Medical Center, Sacramento, California 95817, USA. tenordahl@ucdavis.edu
Salo
Ruth
R
Leamon
Martin
M
D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D003071:Cognition / Q000187:drug effects*; D003952:Diagnostic Imaging / Q000379:methods; D004298:Dopamine / Q000378:metabolism; D004594:Electrophysiology / Q000379:methods; D006801:Humans; D008694:Methamphetamine / Q000009:adverse effects* / Q000737:chemistry; D018377:Neurotransmitter Agents / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D019966:Substance-Related Disorders
D000697:Central Nervous System Stimulants; D018377:Neurotransmitter Agents; D012701:Serotonin; D008694:Methamphetamine; D004298:Dopamine