Infectious mononucleosis progressing to fatal malignant lymphoma: a case report and review of the literature.
Epstein-Barr virus (EBV) infection is nearly ubiquitous. While most primary EBV infections aremild and self-limited, occasional patients will develop severe complications of infectious mononucleosis (IM). Potentially fatal complications include fulminant hepatic failure, virus associated hemophagocytic syndrome and lymphoproliferative disorders. We report the case of an apparently immunocompetent 21-year-old woman with IM that progressed within weeks from a polyclonal B cell proliferation to a fatal B cell lymphoma.
Kobbervig
C
C
Department of Medicine, Hematology Section, University of Wisconsin Hospital and Clinics, Madison, WI, USA.
Norback
D
D
Kahl
B
B
D000328:Adult; D001402:B-Lymphocytes / Q000378:metabolism; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications* / Q000175:diagnosis; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000209:etiology*