Fibrillary glomerulonephritis with hypocomplementemia.
A 59-year-old man was referred for evaluation of nephrotic syndrome. The patient was diagnosed to have rheumatoid arthritis and had been treated for 10 years. Renal biopsy showed mesangial proliferation with small nodular formations, which were determined as fibrillary deposits (average diameter: 20 nm) by electromicroscopy. Congo-red stain was negative. The laboratory findings revealed hypocomplementemia and lambda type of Bence-Jones protein in urine without other systemic diseases including multiple myeloma. Immunosuppressive therapy did not attenuate the nephrotic-range proteinuria. Such a case of fibrillary glomerulonephritis with hypocomplementemia is rare.
Suzuki
Satoshi
S
First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata.
Konta
Tsuneo
T
Koizumi
Ryo
R
Nishida
Wakako
W
Abiko
Hiroshi
H
Kubota
Isao
I
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications; D001536:Bence Jones Protein / Q000652:urine; D003165:Complement System Proteins / Q000032:analysis / Q000276:immunology*; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000209:etiology*; D017211:Treatment Failure
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D001536:Bence Jones Protein; D003165:Complement System Proteins