[Method of pharmacological treatment of the consequences of hypoxia in critically ill patients with acute poisoning].
The multi-factor effect of pharmacological preparations reamberine and citotoflavine, which contain succinate, in critical conditions is preconditioned by the impact they produce on a total energy deficit caused by a long-term hypoxia. The correction of energy deficit improves the therapy of patients in coma, which resulted from poisonings by neurotropic substances. The therapeutic effect manifested itself through a shorter state of coma from 25 to 12.5%. However, an analysis of died patients, who received the metabolic antihypoxants, showed that these drugs are not effective, when the time lapse from poisoning to medical aid exceeded 20 hours. When perftoran, a corrector of oxygen transport, and antihypoxant cytoflavin were added to the therapy scheme, it resulted in that 22 of 24 patients, who were also taken to clinic in the state of coma after 20 and more hours, survived, while all patients in the comparison group (20 patients) died despite an intensive therapy.
Livanov
G A
GA
Moroz
V V
VV
Batotsirenov
B V
BV
Lodiagin
A N
AN
Andrianov
A Iu
AIu
Bazarova
V G
VG
D003128:Coma / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D003422:Critical Care; D004734:Energy Metabolism / Q000187:drug effects; D005466:Fluorocarbons / Q000627:therapeutic use*; D006801:Humans; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008054:Lipid Peroxides / Q000097:blood; D020258:Neurotoxicity Syndromes / Q000150:complications*; D010100:Oxygen / Q000378:metabolism; D012720:Severity of Illness Index; D019802:Succinic Acid / Q000627:therapeutic use*; D016896:Treatment Outcome
D005466:Fluorocarbons; D008054:Lipid Peroxides; C063334:perftoran; D019802:Succinic Acid; D010100:Oxygen