title: Influence of apolipoprotein E genotype on the response to caloric restriction in type 2 diabetic patients with hyperlipidaemia.
abstract: OBJECTIVE
  Hyperlipidaemia is a major predisposing factor to atherosclerosis in patients with type 2 diabetes. Apolipoprotein (apo) E polymorphism influences lipoprotein metabolism, and the present study was undertaken to explore the relation, in type 2 diabetics, between apo E genotype and the plasma lipid response to dietary therapy.
  
  
  METHODS
  The subjects were 104 patients with type 2 diabetes and hyperlipidaemia, and the difference, due to apo E genotype, in dietary response was followed for 4-6 weeks. The caloric intake was maintained in the range 20-25 kcal/kg, and the medications for diabetes were not changed during the follow-up period.
  
  
  RESULTS
  Plasma total cholesterol (TC) and triglyceride (TG) levels were significantly lowered by the dietary treatment in patients with apo E genotypes of epsilon3/3, epsilon2/3 and epsilon3/4; however, the lipid levels in patients with epsilon2/4 did not respond to the diet.
  
  
  CONCLUSIONS
  apo E genotype should be taken into consideration in the treatment of hyperlipidaemia in diabetic patients.
authors.affiliation: Third Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan. tmsw@cc.hirosaki-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Tamasawa
authors.forename: H
authors.initials: H
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Yamato
authors.forename: J
authors.initials: J
authors.lastname: Matsui
authors.forename: J
authors.initials: J
authors.lastname: Tanabe
authors.forename: T
authors.initials: T
authors.lastname: Suda
mesh_terms: D000328:Adult; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000178:diet therapy* / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000178:diet therapy* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D001057:Apolipoproteins E; D014280:Triglycerides; D002784:Cholesterol